Selective synthesis of cis- and trans-[(NHC(Me))2PtCl2] and [NHC(Me)Pt(cod)Cl][NHC(Me)PtCl3] using NHC(Me)SiCl4.

PubMed

Lewis-Alleyne, Lesley C; Bassil, Bassem S; Böttcher, Tobias; Röschenthaler, Gerd-Volker

2014-11-14

NHC(Me)SiCl4 (NHC(Me) = 1,3-dimethylimidazolidin-2-ylidene) was used to synthesise novel NHC(Me)-Pt(ii) complexes. An atypical trans-cis isomerisation process was also achieved for [(NHC(Me))2PtCl2], while the synthesis of the unique double-complex salt [(NHC(Me))Pt(cod)Cl] [(NHC(Me))PtCl3] (cod = 1,5-cyclooctadiene) revealed the first-ever N-heterocyclic carbene analogue of the Cossa's salt anion.

Deterministic quantum splitter based on time-reversed Hong-Ou-Mandel interference

DOE Office of Scientific and Technical Information (OSTI.GOV)

Chen, Jun; Lee, Kim Fook; Kumar, Prem

2007-09-15

By utilizing a fiber-based indistinguishable photon-pair source in the 1.55 {mu}m telecommunications band [J. Chen et al., Opt. Lett. 31, 2798 (2006)], we present the first, to the best of our knowledge, deterministic quantum splitter based on the principle of time-reversed Hong-Ou-Mandel quantum interference. The deterministically separated identical photons' indistinguishability is then verified by using a conventional Hong-Ou-Mandel quantum interference, which exhibits a near-unity dip visibility of 94{+-}1%, making this quantum splitter useful for various quantum information processing applications.

DeepMeSH: deep semantic representation for improving large-scale MeSH indexing

PubMed Central

Peng, Shengwen; You, Ronghui; Wang, Hongning; Zhai, Chengxiang; Mamitsuka, Hiroshi; Zhu, Shanfeng

2016-01-01

Motivation: Medical Subject Headings (MeSH) indexing, which is to assign a set of MeSH main headings to citations, is crucial for many important tasks in biomedical text mining and information retrieval. Large-scale MeSH indexing has two challenging aspects: the citation side and MeSH side. For the citation side, all existing methods, including Medical Text Indexer (MTI) by National Library of Medicine and the state-of-the-art method, MeSHLabeler, deal with text by bag-of-words, which cannot capture semantic and context-dependent information well. Methods: We propose DeepMeSH that incorporates deep semantic information for large-scale MeSH indexing. It addresses the two challenges in both citation and MeSH sides. The citation side challenge is solved by a new deep semantic representation, D2V-TFIDF, which concatenates both sparse and dense semantic representations. The MeSH side challenge is solved by using the ‘learning to rank’ framework of MeSHLabeler, which integrates various types of evidence generated from the new semantic representation. Results: DeepMeSH achieved a Micro F-measure of 0.6323, 2% higher than 0.6218 of MeSHLabeler and 12% higher than 0.5637 of MTI, for BioASQ3 challenge data with 6000 citations. Availability and Implementation: The software is available upon request. Contact: zhusf@fudan.edu.cn Supplementary information: Supplementary data are available at Bioinformatics online. PMID:27307646

DeepMeSH: deep semantic representation for improving large-scale MeSH indexing.

PubMed

Peng, Shengwen; You, Ronghui; Wang, Hongning; Zhai, Chengxiang; Mamitsuka, Hiroshi; Zhu, Shanfeng

2016-06-15

Medical Subject Headings (MeSH) indexing, which is to assign a set of MeSH main headings to citations, is crucial for many important tasks in biomedical text mining and information retrieval. Large-scale MeSH indexing has two challenging aspects: the citation side and MeSH side. For the citation side, all existing methods, including Medical Text Indexer (MTI) by National Library of Medicine and the state-of-the-art method, MeSHLabeler, deal with text by bag-of-words, which cannot capture semantic and context-dependent information well. We propose DeepMeSH that incorporates deep semantic information for large-scale MeSH indexing. It addresses the two challenges in both citation and MeSH sides. The citation side challenge is solved by a new deep semantic representation, D2V-TFIDF, which concatenates both sparse and dense semantic representations. The MeSH side challenge is solved by using the 'learning to rank' framework of MeSHLabeler, which integrates various types of evidence generated from the new semantic representation. DeepMeSH achieved a Micro F-measure of 0.6323, 2% higher than 0.6218 of MeSHLabeler and 12% higher than 0.5637 of MTI, for BioASQ3 challenge data with 6000 citations. The software is available upon request. zhusf@fudan.edu.cn Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Alkyl complexes of strontium and barium: synthesis and structural characterization of [(Me3Si)2(MeOMe2Si)C]2Sr(THF) and [(Me3Si)2(MeOMe2Si)C]2Ba(MeOCH2CH2OMe).

PubMed

Izod, Keith; Liddle, Stephen T; Clegg, William

2003-06-25

Metathesis between either SrI2 or BaI2 and 2 equiv of {(Me3Si)2(MeOMe2Si)C}K in THF yields the novel heavier alkali metal dialkyls {(Me3Si)2(MeOMe2Si)C}2M(L) [M(L) = Sr(THF) (2), Ba(DME) (3) (DME = 1,2-dimethoxyethane)] after recrystallization.

MeSH Now: automatic MeSH indexing at PubMed scale via learning to rank.

PubMed

Mao, Yuqing; Lu, Zhiyong

2017-04-17

MeSH indexing is the task of assigning relevant MeSH terms based on a manual reading of scholarly publications by human indexers. The task is highly important for improving literature retrieval and many other scientific investigations in biomedical research. Unfortunately, given its manual nature, the process of MeSH indexing is both time-consuming (new articles are not immediately indexed until 2 or 3 months later) and costly (approximately ten dollars per article). In response, automatic indexing by computers has been previously proposed and attempted but remains challenging. In order to advance the state of the art in automatic MeSH indexing, a community-wide shared task called BioASQ was recently organized. We propose MeSH Now, an integrated approach that first uses multiple strategies to generate a combined list of candidate MeSH terms for a target article. Through a novel learning-to-rank framework, MeSH Now then ranks the list of candidate terms based on their relevance to the target article. Finally, MeSH Now selects the highest-ranked MeSH terms via a post-processing module. We assessed MeSH Now on two separate benchmarking datasets using traditional precision, recall and F 1 -score metrics. In both evaluations, MeSH Now consistently achieved over 0.60 in F-score, ranging from 0.610 to 0.612. Furthermore, additional experiments show that MeSH Now can be optimized by parallel computing in order to process MEDLINE documents on a large scale. We conclude that MeSH Now is a robust approach with state-of-the-art performance for automatic MeSH indexing and that MeSH Now is capable of processing PubMed scale documents within a reasonable time frame. http://www.ncbi.nlm.nih.gov/CBBresearch/Lu/Demo/MeSHNow/ .

solveME: fast and reliable solution of nonlinear ME models.

PubMed

Yang, Laurence; Ma, Ding; Ebrahim, Ali; Lloyd, Colton J; Saunders, Michael A; Palsson, Bernhard O

2016-09-22

Genome-scale models of metabolism and macromolecular expression (ME) significantly expand the scope and predictive capabilities of constraint-based modeling. ME models present considerable computational challenges: they are much (>30 times) larger than corresponding metabolic reconstructions (M models), are multiscale, and growth maximization is a nonlinear programming (NLP) problem, mainly due to macromolecule dilution constraints. Here, we address these computational challenges. We develop a fast and numerically reliable solution method for growth maximization in ME models using a quad-precision NLP solver (Quad MINOS). Our method was up to 45 % faster than binary search for six significant digits in growth rate. We also develop a fast, quad-precision flux variability analysis that is accelerated (up to 60× speedup) via solver warm-starts. Finally, we employ the tools developed to investigate growth-coupled succinate overproduction, accounting for proteome constraints. Just as genome-scale metabolic reconstructions have become an invaluable tool for computational and systems biologists, we anticipate that these fast and numerically reliable ME solution methods will accelerate the wide-spread adoption of ME models for researchers in these fields.

40 CFR 721.10483 - Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Siloxanes and Silicones, di-Me, Me... Substances § 721.10483 Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with...) The chemical substance identified as Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated...

40 CFR 721.10483 - Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Siloxanes and Silicones, di-Me, Me... Substances § 721.10483 Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with...) The chemical substance identified as Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated...

What Makes Me Sneeze?

MedlinePlus

... Videos for Educators Search English Español What Makes Me Sneeze? KidsHealth / For Kids / What Makes Me Sneeze? Print en español ¿Qué me hace estornudar? AHHH . . . CHOO! If you just sneezed, ...

'It's personal to me': A qualitative study of depression in young people with CFS/ME.

PubMed

Taylor, Anna K; Loades, Maria; Brigden, Amberly Lc; Collin, Simon M; Crawley, Esther

2017-04-01

Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has a prevalence of 0.4-2.4% and is defined as 'generalised disabling fatigue persisting after routine tests and investigations have failed to identify an obvious underlying cause'. One-third of young people with CFS/ME have probable depression. Little is known about why depression develops, the relationship between depression and CFS/ME, or what treatment might be helpful. We conducted nine semi-structured interviews with young people with CFS/ME (aged 13-17 years, 8/9 female) and probable depression, covering perceived causes of depression, the relationship between CFS/ME and depression, and treatment strategies. Most thought CFS/ME caused depression. Many discussed a cyclical relationship: low mood made CFS/ME worse. A sense of loss was common. CFS/ME restricted activities participants valued and changed systemic structures, causing depression. There was no single helpful treatment approach. Individualised approaches using combinations of cognitive behavioural therapy (CBT), medication, activity management and other strategies were described. This study suggests that depression may be secondary to CFS/ME in young people because of the impact of CFS/ME on quality of life. Clinicians treating young people with CFS/ME need to consider strategies to prevent development of depression, and research is needed into approaches that are effective in treating CFS/ME with co-morbid depression.

Carotid intima-media thickness in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil): a narrative review.

PubMed

Santos, Eduardo Henrique Sena; Santos Neto, Pedro José Dos; Santos, Itamar de Souza

2018-01-01

Carotid intima-media thickness (CIMT), as measured by ultrasound, has been used in large studies as a non-invasive marker for subclinical atherosclerosis. The Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) is a cohort of 15,105 civil servants in six Brazilian cities that included CIMT evaluation in its baseline assessment. The aim of the present narrative review was to provide an overview of ELSA-Brasil CIMT articles published up to July 31, 2017. Narrative review of ELSA-Brasil CIMT studies using baseline assessment data. We searched PubMed for the terms "ELSA-Brasil" and "intima-media". This search yielded 21 published articles using CIMT data from the ELSA-Brasil baseline assessment, which were included in this review. We also present information about intima-media thickness assessment from ongoing onsite reevaluations of the study participants. Most published studies focused on the association with traditional and novel cardiovascular risk factors. Studies also presented information about the ELSA-Brasil CIMT protocol at baseline and CIMT value distribution in this large sample. Analyses on the ELSA-Brasil data led to important insights on CIMT interpretation and physiology. Besides the highlighted contributions which have already been made in this field, new data gathered during the ongoing third onsite assessment will enable investigation of substantially new research questions.

Magnetoelectric(ME) Composites and Functional Devices Based on ME Effect

NASA Astrophysics Data System (ADS)

Gao, Junqi

Magnetoelectric (ME) effect, a cross-coupling effect between magnetic and electric orders, has stimulated lots of investigations due to the potential for applications as multifunctional devices. In this thesis, I have investigated and optimized the ME effect in Metglas/piezo-fibers ME composites with a multi-push pull configuration. Moreover, I have also proposed several devices based on such composites. In this thesis, several methods for ME composites optimization have been investigated. (i) the ME coefficients can be enhanced greatly by using single crystal fibers with high piezoelectric properties; (ii) the influence of volume ratio between Metglas and piezo-fibers on ME coefficients has been studied both experimentally and theoretically. Modulating the volume ratio can increase the ME coefficient greatly; and (iii) the annealing process can change the properties of Metglas, which can enhance the ME response as well. Moreover, one differential structure for ME composites has been proposed, which can reject the external vibration noise by a factor of 10 to 20 dB. This differential structure may allow for practical applications of such sensors in real-world environments. Based on optimized ME composites, two types of AC magnetic sensor have been developed. The objective is to develop one alternative type of magnetic sensor with low noise, low cost and room-temperature operation; that makes the sensor competitive with the commercially available magnetic sensor, such as Fluxgate, GMR, SQUID, etc. Conventional passive sensors have been fully investigated, including the design of sensor working at specific frequency range, sensitivity, noise density characterization, etc. Furthermore, the extremely low frequency (< 10-3 Hz) magnetic sensor has undergone a redesign of the charge amplifier circuit. Additionally, the noise model has been established to simulate the noise density for this device which can predict the noise floor precisely. Based on theoretical noise

MeSHLabeler: improving the accuracy of large-scale MeSH indexing by integrating diverse evidence.

PubMed

Liu, Ke; Peng, Shengwen; Wu, Junqiu; Zhai, Chengxiang; Mamitsuka, Hiroshi; Zhu, Shanfeng

2015-06-15

Medical Subject Headings (MeSHs) are used by National Library of Medicine (NLM) to index almost all citations in MEDLINE, which greatly facilitates the applications of biomedical information retrieval and text mining. To reduce the time and financial cost of manual annotation, NLM has developed a software package, Medical Text Indexer (MTI), for assisting MeSH annotation, which uses k-nearest neighbors (KNN), pattern matching and indexing rules. Other types of information, such as prediction by MeSH classifiers (trained separately), can also be used for automatic MeSH annotation. However, existing methods cannot effectively integrate multiple evidence for MeSH annotation. We propose a novel framework, MeSHLabeler, to integrate multiple evidence for accurate MeSH annotation by using 'learning to rank'. Evidence includes numerous predictions from MeSH classifiers, KNN, pattern matching, MTI and the correlation between different MeSH terms, etc. Each MeSH classifier is trained independently, and thus prediction scores from different classifiers are incomparable. To address this issue, we have developed an effective score normalization procedure to improve the prediction accuracy. MeSHLabeler won the first place in Task 2A of 2014 BioASQ challenge, achieving the Micro F-measure of 0.6248 for 9,040 citations provided by the BioASQ challenge. Note that this accuracy is around 9.15% higher than 0.5724, obtained by MTI. The software is available upon request. © The Author 2015. Published by Oxford University Press.

MeSHLabeler: improving the accuracy of large-scale MeSH indexing by integrating diverse evidence

PubMed Central

Liu, Ke; Peng, Shengwen; Wu, Junqiu; Zhai, Chengxiang; Mamitsuka, Hiroshi; Zhu, Shanfeng

2015-01-01

Motivation: Medical Subject Headings (MeSHs) are used by National Library of Medicine (NLM) to index almost all citations in MEDLINE, which greatly facilitates the applications of biomedical information retrieval and text mining. To reduce the time and financial cost of manual annotation, NLM has developed a software package, Medical Text Indexer (MTI), for assisting MeSH annotation, which uses k-nearest neighbors (KNN), pattern matching and indexing rules. Other types of information, such as prediction by MeSH classifiers (trained separately), can also be used for automatic MeSH annotation. However, existing methods cannot effectively integrate multiple evidence for MeSH annotation. Methods: We propose a novel framework, MeSHLabeler, to integrate multiple evidence for accurate MeSH annotation by using ‘learning to rank’. Evidence includes numerous predictions from MeSH classifiers, KNN, pattern matching, MTI and the correlation between different MeSH terms, etc. Each MeSH classifier is trained independently, and thus prediction scores from different classifiers are incomparable. To address this issue, we have developed an effective score normalization procedure to improve the prediction accuracy. Results: MeSHLabeler won the first place in Task 2A of 2014 BioASQ challenge, achieving the Micro F-measure of 0.6248 for 9,040 citations provided by the BioASQ challenge. Note that this accuracy is around 9.15% higher than 0.5724, obtained by MTI. Availability and implementation: The software is available upon request. Contact: zhusf@fudan.edu.cn PMID:26072501

Meshable: searching PubMed abstracts by utilizing MeSH and MeSH-derived topical terms.

PubMed

Kim, Sun; Yeganova, Lana; Wilbur, W John

2016-10-01

Medical Subject Headings (MeSH(®)) is a controlled vocabulary for indexing and searching biomedical literature. MeSH terms and subheadings are organized in a hierarchical structure and are used to indicate the topics of an article. Biologists can use either MeSH terms as queries or the MeSH interface provided in PubMed(®) for searching PubMed abstracts. However, these are rarely used, and there is no convenient way to link standardized MeSH terms to user queries. Here, we introduce a web interface which allows users to enter queries to find MeSH terms closely related to the queries. Our method relies on co-occurrence of text words and MeSH terms to find keywords that are related to each MeSH term. A query is then matched with the keywords for MeSH terms, and candidate MeSH terms are ranked based on their relatedness to the query. The experimental results show that our method achieves the best performance among several term extraction approaches in terms of topic coherence. Moreover, the interface can be effectively used to find full names of abbreviations and to disambiguate user queries. https://www.ncbi.nlm.nih.gov/IRET/MESHABLE/ CONTACT: sun.kim@nih.gov Supplementary data are available at Bioinformatics online. © The Author 2016. Published by Oxford University Press.

Hey! A Scorpion Stung Me!

MedlinePlus

... arachnid family, which also includes mites, ticks , and spiders. Scorpions are about 3 inches long (about the ... A Bee Stung Me! Hey! A Black Widow Spider Bit Me! Hey! A Mosquito Bit Me! Hey! ...

Fiabilité des structures mécaniques adaptatives: effet de la panne des actionneurs ou des capteurs sur la stabilité

NASA Astrophysics Data System (ADS)

Fall, H.; Charon, W.; Kouta, R.

2002-12-01

Ces dernières décennies, des activités significatives dans le monde étaient dirigées autour du contrôle actif. Le but de ces recherches était essentiellement d'améliorer les performances, la fiabilité et la sécurité des systèmes. Notamment dans le cas des structures soumises à des vibrations aléatoires. D'importants travaux ont été consacré à l'utilisation des “matériaux intelligents” comme capteurs et actionneurs. Cette article propose l'analyse de la fiabilité des systèmes mécaniques en étudiant les pannes des actionneurs ou des capteurs. L'effet de ces pannes sur la stabilité et la performance du système y est démontré. Les méthodologies de conception y sont rappelées. Des exemples numériques sont fournis à travers le contrôle d'un panneau sous chargement dynamique pour illustrer la méthode proposée.

Beginnings of a good apoptotic meal: the find-me and eat-me signaling pathways

PubMed Central

Ravichandran, Kodi S.

2011-01-01

Prompt and efficient clearance of apoptotic cells is necessary to prevent secondary necrosis of dying cells, and to avoid immune responses to autoantigens. Recent studies have shed light on how apoptotic cells through soluble ‘find-me signals’ advertise their presence to phagocytes at the earliest stages of cell death. Phagocytes sense the find-me signal gradient, and in turn the presence of dying cells, and migrate to their vicinity. The apoptotic cells also expose specific eat-me signals on their surface that are recognized by phagocytes through specific engulfment receptors. This review covers the recent progress in the areas of find-me and eat-me signals, and how these relate to prompt and immunologically silent clearance of apoptotic cells. PMID:22035837

Sidi Ali Ou Azza (L4): A New Moroccan Fall

NASA Astrophysics Data System (ADS)

Chennaoui Aoudjehane, H.; Agee, C. B.; Aaranson, A.; Bouragaa, A.

2016-08-01

Sidi Ali Ou Azza is the latest meteorite fall in Morocco, it occurred on 28 July 2015 very close (about 40 km) to Tissint martian shergottite fall that occurred on 18 July 2011. It's one of the small group of 23 L4 ordinary chondrite falls.

Functional analysis of MeCIPK23 and MeCBL1/9 in cassava defense response against Xanthomonas axonopodis pv. manihotis.

PubMed

Yan, Yu; He, Xinyi; Hu, Wei; Liu, Guoyin; Wang, Peng; He, Chaozu; Shi, Haitao

2018-06-01

MeCIPK23 interacts with MeCBL1/9, and they confer improved defense response, providing potential genes for further genetic breeding in cassava. Cassava (Manihot esculenta) is an important food crop in tropical area, but its production is largely affected by cassava bacterial blight. However, the information of defense-related genes in cassava is very limited. Calcium ions play essential roles in plant development and stress signaling pathways. Calcineurin B-like proteins (CBLs) and CBL-interacting protein kinases (CIPKs) are crucial components of calcium signals. In this study, systematic expression profile of 25MeCIPKs in response to Xanthomonas axonopodis pv. manihotis (Xam) infection was examined, by which seven candidate MeCIPKs were chosen for functional investigation. Through transient expression in Nicotiana benthamiana leaves, we found that six MeCIPKs (MeCIPK5, MeCIPK8, MeCIPK12, MeCIPK22, MeCIPK23 and MeCIPK24) conferred improved defense response, via regulating the transcripts of several defense-related genes. Notably, we found that MeCIPK23 interacted with MeCBL1 and MeCBL9, and overexpression of these genes conferred improved defense response. On the contrary, virus-induced gene silencing of either MeCIPK23 or MeCBL1/9 or both genes resulted in disease sensitive in cassava. To our knowledge, this is the first study identifying MeCIPK23 as well as MeCBL1 and MeCBL9 that confer enhanced defense response against Xam.

Analyse de l'effet des courants induits sur l'impédance d'un système électromagnétique alimenté en tension BF ou HF. Utilisation de la méthode des circuits couplés

NASA Astrophysics Data System (ADS)

Maouche, B.; Feliachi, M.

1997-10-01

In this paper, a study of the interaction between the inductor and the load of an axisymmetrical induction device is proposed. This interaction concerns the effect of the eddy current on both the excitation current and on the system impedance. A half analytical model, based on a numerical discretization of the electromagnetic solution domain, is used. In each cell of the numerical discretization, an analytical calculation using the Moment Method (MM) is considered. In the case of strong skin effect (High Frequency: HF), the formulation makes use of the Impedance Boundary Condition (IBC); in the contrary case (Low Frequency: LF), the interior domain is discretized. Dans cet article nous proposons l'étude de l'influence d'une charge (induit) conductrice sur la répartition du courant inducteur ainsi que sur l'impédance du système. L'inducteur est à géométrie axisymétrique de forme solénoïdale ou pancake destiné au chauffage par induction. Une méthode semi-analytique, basée sur une discrétisation du domaine en mailles élémentaires auxquelles s'applique une formulation intégrale (Méthode des Circuits Couplés : MCC) des grandeurs électromagnétiques, est utilisée. Dans le cas où l'effet de peau est important (Haute Fréquence:HF), la formulation associe la Condition d'Impédance de Surface; dans le cas contraire (Basse Fréquence : BF), un maillage du domaine interne est pratiqué.

Hey! A Bedbug Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Bedbug Bit Me! KidsHealth / For Kids / Hey! A Bedbug Bit Me! Print en español ¡Ay! ¡ ... of them. More on this topic for: Kids Hey! A Bee Stung Me! Hey! A Scorpion Stung ...

Hey! A Tick Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Tick Bit Me! KidsHealth / For Kids / Hey! A Tick Bit Me! Print en español ¡Ay! ¡ ... tick collar. More on this topic for: Kids Hey! A Brown Recluse Spider Bit Me! Hey! A ...

Hey! A Tarantula Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Tarantula Bit Me! KidsHealth / For Kids / Hey! A Tarantula Bit Me! Print en español ¡Ay! ¡ ... you alone. More on this topic for: Kids Hey! A Fire Ant Stung Me! Hey! A Scorpion ...

Hey! A Flea Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Flea Bit Me! KidsHealth / For Kids / Hey! A Flea Bit Me! Print en español ¡Ay! ¡ ... 30% DEET. More on this topic for: Kids Hey! A Gnat Bit Me! Hey! A Bedbug Bit ...

Hey! A Gnat Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Gnat Bit Me! KidsHealth / For Kids / Hey! A Gnat Bit Me! Print en español ¡Ay! ¡ ... and streams. More on this topic for: Kids Hey! A Fire Ant Stung Me! Hey! A Flea ...

Hey! A Louse Bit Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Louse Bit Me! KidsHealth / For Kids / Hey! A Louse Bit Me! Print en español ¡Ay! ¡ ... topic for: Kids Lice Aren't So Nice Hey! A Gnat Bit Me! Hey! A Flea Bit ...

40 CFR 721.10482 - Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with silica.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Siloxanes and Silicones, di-Me, Me... Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with silica. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as Siloxanes and Silicones...

40 CFR 721.10482 - Siloxanes and Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with silica.

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Siloxanes and Silicones, di-Me, Me... Silicones, di-Me, Me vinyl, hydroxy-terminated, reaction products with silica. (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified as Siloxanes and Silicones...

Improving weather modeling in South America through IDD-Brasil

NASA Astrophysics Data System (ADS)

Chagas, G. O.

2007-05-01

The IDD-Brasil constitutes of an international collaboration among Universidade Federal do Rio de Janeiro (LPM/UFRJ), Centro de Previsão de Tempo e Estudos Climáticos (CPTEC/INPE) and the Unidata Program Center (Unidata/UCAR), which connects several universities and research centers across the Americas in a network to share real-time hydro meteorological data. Using this network as a new path to deliver and acquire observational data, IDD-Brazil participants are capable of receiving observational data from GTS (Global Telecommunication System), locally ingested data from several automatic weather stations networks (mesonets) from INPE, the entire array of METAR and SYNOP observations, and several model outputs and satellite imagery. During recent years Numerical Models have been used constantly, especially in mesoscale research, but the lack of a dense observational network in South America leads to several constraints during the data assimilation and model validation. Since the IDD-Brasil offers an improved and simple method to have new datasets readily accessible, it has been used continuously as a new manner to distribute surface observations that are not currently available in GTS, such as several mesonets in Brazil that account for an increase in data density. Through the usage of data ingested in IDD-Brasil as guess fields it is possible to study how the assimilation in several global models frequently used as initial conditions for mesoscale simulations can be affected, since in certain areas in Brazil the density of data nearly doubles if compared to GTS. Therefore it is also possible to better validate the results generated in mesoscale simulations, in view of the fact that the network has an improved spatial distribution. It is expected that the increase of locally held numerical model output from South American institutions in IDD- Brasil leads to an increased awareness of the need to constantly validate these results with observational data, thus

40 CFR 721.9516 - Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with...

Code of Federal Regulations, 2010 CFR

2010-07-01

...-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene glycol Bu glycidal..., reaction products with polyethylene-polypropylene glycol Bu glycidal ether. (a) Chemical substance and... silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene...

40 CFR 721.9516 - Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with...

Code of Federal Regulations, 2011 CFR

2011-07-01

...-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene glycol Bu glycidal..., reaction products with polyethylene-polypropylene glycol Bu glycidal ether. (a) Chemical substance and... silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene...

Hong-Ou-Mandel Gravitational Wave Space spectrometER - HOMER mission

NASA Astrophysics Data System (ADS)

Jacinto de Matos, Clovis; Tajmar, Martin

2018-06-01

Michelson type gravitational wave detectors measure the strain caused by gravitational waves on the interferometer's arms. Gravitational waves can also cause the rotation of photon's linear polarization vector, thus disturbing the interference of entangled photons in Hong-Ou-Mandel (HOM) interferometers. Here one uses that physical phenomenon to devise a spectrometer for gravitational waves through the implementation of a Hong-Ou-Mandel interferometer in Earth geostationary orbit with a constellation of three different spacecraft in accurate formation flight. We call this mission, the Hong-Ou-Mandel Gravitational Waves Space SpectrometER (HOMER). HOMER will cover the part of the gravitational wave spectrum with wavelengths around λ =105 km, which falls between the long wavelength detection range of LISA, around λ =106 km, and of ground based detectors like LIGO, around λ =103 km. With respect to Michelson type detectors, the proposed concept for the detection and spectral analysis of gravitational waves has the advantage of operating without the need of drag free satellites, however it requires a relative precision of the attitude between satellites of the order of the gravitational waves amplitude δθ / θ ∼ h ∼10-20 , which makes the architecture of the HOMER mission as challenging as the Michelson type space detectors. The difficulty being however transferred from the monitoring of the relative distance between spacecraft (for Michelson antennas) to their relative attitude. By focusing on photons polarization instead of photons phase one can measure the spectrum of the detected gravitational signal. As a bonus, the proposed instrument could also investigate the influence of spacetime curvature on photons quantum entanglement, thus experimentally peering into the relation between general relativity and quantum mechanics, which is currently a subject of high interest in theoretical physics. This paper will describe the HOMER mission concept in general and

[Design and implementation of the ELSA-Brasil biobank: a prospective study in a Brazilian population].

PubMed

Pereira, Alexandre C; Bensenor, Isabela M; Fedeli, Ligia M; Castilhos, Cristina; Vidigal, Pedro G; Maniero, Viviane; Leite, Claudia M; Pimentel, Robercia A; Duncan, Bruce B; Mill, Jose Geraldo; Lotufo, Paulo A

2013-06-01

The Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) is a multicenter prospective cohort of civil servants designed to assess the determinants of chronic diseases, especially cardiovascular diseases and type 2 diabetes. The present article describes the main design and implementation points of the ELSA-Brasil biobank project. Economic, political, logistical and technological aspects of this study are characterized. Additionally, it discusses the final biorepository protocol and the facilities implemented to achieve this objective. The design and implementation process of the ELSA-Brasil biobank took three years to be performed. Both the central and local biobanks were built according to the best biorepository techniques, using different technological solutions for the distinct needs expected in this study.

40 CFR 721.9516 - Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with...

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Siloxanes and silicones, 3-[(2... Specific Chemical Substances § 721.9516 Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me... silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene...

40 CFR 721.9516 - Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with...

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Siloxanes and silicones, 3-[(2... Specific Chemical Substances § 721.9516 Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me... silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene...

40 CFR 721.9516 - Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with...

Code of Federal Regulations, 2014 CFR

2014-07-01

... 40 Protection of Environment 31 2014-07-01 2014-07-01 false Siloxanes and silicones, 3-[(2... Specific Chemical Substances § 721.9516 Siloxanes and silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me... silicones, 3-[(2-aminoethyl) amino]propyl Me, di-Me, reaction products with polyethylene-polypropylene...

Measurement of Thick Target Neutron Yields at 0-Degree Bombarded With 140-MeV, 250-MeV And 350-MeV Protons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Iwamoto, Yosuke; /JAERI, Kyoto; Taniguchi, Shingo

Neutron energy spectra at 0{sup o} produced from stopping-length graphite, aluminum, iron and lead targets bombarded with 140, 250 and 350 MeV protons were measured at the neutron TOF course in RCNP of Osaka University. The neutron energy spectra were obtained by using the time-of-flight technique in the energy range from 10 MeV to incident proton energy. To compare the experimental results, Monte Carlo calculations with the PHITS and MCNPX codes were performed using the JENDL-HE and the LA150 evaluated nuclear data files, the ISOBAR model implemented in PHITS, and the LAHET code in MCNPX. It was found that thesemore » calculated results at 0{sup o} generally agreed with the experimental results in the energy range above 20 MeV except for graphite at 250 and 350 MeV.« less

Attosecond-resolution Hong-Ou-Mandel interferometry.

PubMed

Lyons, Ashley; Knee, George C; Bolduc, Eliot; Roger, Thomas; Leach, Jonathan; Gauger, Erik M; Faccio, Daniele

2018-05-01

When two indistinguishable photons are each incident on separate input ports of a beamsplitter, they "bunch" deterministically, exiting via the same port as a direct consequence of their bosonic nature. This two-photon interference effect has long-held the potential for application in precision measurement of time delays, such as those induced by transparent specimens with unknown thickness profiles. However, the technique has never achieved resolutions significantly better than the few-femtosecond (micrometer) scale other than in a common-path geometry that severely limits applications. We develop the precision of Hong-Ou-Mandel interferometry toward the ultimate limits dictated by statistical estimation theory, achieving few-attosecond (or nanometer path length) scale resolutions in a dual-arm geometry, thus providing access to length scales pertinent to cell biology and monoatomic layer two-dimensional materials.

[ELSA-Brasil strategies for outcome identification, investigation and ascertainment].

PubMed

Barreto, Sandhi Maria; Ladeira, Roberto Marini; Bastos, Maria do Socorro Castelo Branco de Oliveira; Diniz, Maria de Fátima Haueisen Sander; Jesus, Elcimara Amorim de; Kelles, Silvana Márcia Bruschi; Luft, Vivian Cristine; Melo, Enirtes Caetano Prates; Oliveira, Elizabete Regina Araújo de

2013-06-01

The article describes the strategies adopted by the Brazilian Longitudinal Study for Adult Health (ELSA-Brasil) for participation and retention of subjects. This is key to ensure internal validity of longitudinal studies, and to identify, investigate, and ascertain outcomes of interest. The follow-up strategies include annual telephone contacts with new assessments and interviews every three to four years this approach aims to identify transient outcomes (reversible or not), permanent outcomes as well as complications related to the progression of major diseases--cardiovascular diseases and diabetes--to be studied. Telephone interviews are designed to monitor subjects' health status and to identify potential health-related events such as hospital admissions, medical visits or pre-selected medical procedures. Subjects are also encouraged to report to the ELSA-Brasil team any new health-related events. When a potential event is identified, a thorough investigation is carried out to collect relevant information about that event from medical records. All data are blinded and reviewed and analyzed by a medical expert committee. Incident outcome ascertainment follows well-established international criteria to ensure data comparability and avoid misclassification. In addition to these strategies, the occurrence of health-related events is also investigated through linkage of secondary databases, such as national mortality and hospital admission databases. Accurate identification of outcomes will allow to estimating their incidence in the study cohort and to investigate the effect of the exposures studied in the ELSA-Brasil at baseline and at its subsequent waves.

Secondary Analysis of the "Love Me...Never Shake Me" SBS Education Program

ERIC Educational Resources Information Center

Deyo, Grace; Skybo, Theresa; Carroll, Alisa

2008-01-01

Objective: Shaken baby syndrome (SBS) is preventable; however, an estimated 21-74 per 100,000 children worldwide are victims annually. This study examined the effectiveness of an SBS prevention program in the US. Methods: A descriptive, secondary analysis of the Prevent Child Abuse Ohio (PCAO) "Love Me...Never Shake Me" SBS education program…

Testing the Trower and Chadwick model of paranoia: Is 'poor-me' and 'bad-me' paranoia acting as a defence?

PubMed

Marley, Charles; Jones, Jason; Jones, Christopher A

2017-12-01

The study tested the predicted differences in phenomenology (self-esteem and depression) and insecurity of the subgroups of paranoia proposed by the Trower and Chadwick (1995) model of paranoia. Thirty-two inpatients experiencing persecutory delusions were assigned to either the poor me or bad me paranoid group. Questionnaire assessment of depression and self-esteem were conducted. A Dot Probe task measured detection latency (reaction time) to poor me words, bad me words and neutral words. The poor me and bad me groups displayed the predicted phenomenological differences. The dot probe task did not support the predicted insecurities of the Trower and Chadwick model, but unexpected significant results for the poor me subgroup may offer support for an alternative explanation of paranoia as an unstable phenomenon. Copyright © 2017 Elsevier B.V. All rights reserved.

Hey! A Fire Ant Stung Me!

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Fire Ant Stung Me! KidsHealth / For Kids / Hey! A Fire Ant Stung Me! Print en español ¡ ... with it. More on this topic for: Kids Hey! A Bee Stung Me! Hey! A Scorpion Stung ...

Oxidative stress in MeHg-induced neurotoxicity

DOE Office of Scientific and Technical Information (OSTI.GOV)

Farina, Marcelo, E-mail: farina@ccb.ufsc.br; Aschner, Michael; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN

2011-11-15

Methylmercury (MeHg) is an environmental toxicant that leads to long-lasting neurological and developmental deficits in animals and humans. Although the molecular mechanisms mediating MeHg-induced neurotoxicity are not completely understood, several lines of evidence indicate that oxidative stress represents a critical event related to the neurotoxic effects elicited by this toxicant. The objective of this review is to summarize and discuss data from experimental and epidemiological studies that have been important in clarifying the molecular events which mediate MeHg-induced oxidative damage and, consequently, toxicity. Although unanswered questions remain, the electrophilic properties of MeHg and its ability to oxidize thiols have beenmore » reported to play decisive roles to the oxidative consequences observed after MeHg exposure. However, a close examination of the relationship between low levels of MeHg necessary to induce oxidative stress and the high amounts of sulfhydryl-containing antioxidants in mammalian cells (e.g., glutathione) have led to the hypothesis that nucleophilic groups with extremely high affinities for MeHg (e.g., selenols) might represent primary targets in MeHg-induced oxidative stress. Indeed, the inhibition of antioxidant selenoproteins during MeHg poisoning in experimental animals has corroborated this hypothesis. The levels of different reactive species (superoxide anion, hydrogen peroxide and nitric oxide) have been reported to be increased in MeHg-exposed systems, and the mechanisms concerning these increments seem to involve a complex sequence of cascading molecular events, such as mitochondrial dysfunction, excitotoxicity, intracellular calcium dyshomeostasis and decreased antioxidant capacity. This review also discusses potential therapeutic strategies to counteract MeHg-induced toxicity and oxidative stress, emphasizing the use of organic selenocompounds, which generally present higher affinity for MeHg when compared to the

The biopolitics of CFS/ME.

PubMed

Karfakis, Nikos

2018-06-08

This paper argues that Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) constitutes a biopolitical problem, a scientific object which needs to be studied, classified and regulated. Assemblages of authorities, knowledges and techniques make CFS/ME subjects and shape their everyday conduct in an attempt to increase their supposed autonomy, wellbeing and health. CFS and CFS/ME identities are however made not only through government, scientific, and medical interventions but also by the patients themselves, a biosocial community who collaborates with scientists, educates itself about the intricacies of biomedicine, and contests psychiatric truth claims. CFS/ME is an illness trapped between medicine and psychology, an illness that is open to debate and therefore difficult to manage and standardise. The paper delineates different interventions by medicine, science, the state and the patients themselves and concludes that CFS/ME remains elusive, only partially standardised, in an on-going battle between all the different actors that want to define it for their own situated interests. Copyright © 2018 Elsevier Ltd. All rights reserved.

The different origins of magnetic fields and activity in the Hertzsprung gap stars, OU Andromedae and 31 Comae

NASA Astrophysics Data System (ADS)

Borisova, A.; Aurière, M.; Petit, P.; Konstantinova-Antova, R.; Charbonnel, C.; Drake, N. A.

2016-06-01

Context. When crossing the Hertzsprung gap, intermediate-mass stars develop a convective envelope. Fast rotators on the main sequence, or Ap star descendants, are expected to become magnetic active subgiants during this evolutionary phase. Aims: We compare the surface magnetic fields and activity indicators of two active, fast rotating red giants with similar masses and spectral class but different rotation rates - OU And (Prot = 24.2 d) and 31 Com (Prot = 6.8 d) - to address the question of the origin of their magnetism and high activity. Methods: Observations were carried out with the Narval spectropolarimeter in 2008 and 2013. We used the least-squares deconvolution (LSD) technique to extract Stokes V and I profiles with high signal-to-noise ratio to detect Zeeman signatures of the magnetic field of the stars. We then provide Zeeman-Doppler imaging (ZDI), activity indicators monitoring, and a precise estimation of stellar parameters. We use state-of-the-art stellar evolutionary models, including rotation, to infer the evolutionary status of our giants, as well as their initial rotation velocity on the main sequence, and we interpret our observational results in the light of the theoretical Rossby numbers. Results: The detected magnetic field of OU Andromedae (OU And) is a strong one. Its longitudinal component Bl reaches 40 G and presents an about sinusoidal variation with reversal of the polarity. The magnetic topology of OU And is dominated by large-scale elements and is mainly poloidal with an important dipole component, as well as a significant toroidal component. The detected magnetic field of 31 Comae (31 Com) is weaker, with a magnetic map showing a more complex field geometry, and poloidal and toroidal components of equal contributions. The evolutionary models show that the progenitors of OU And and 31 Com must have been rotating at velocities that correspond to 30 and 53%, respectively, of their critical rotation velocity on the zero age main sequence

MeSHy: Mining unanticipated PubMed information using frequencies of occurrences and concurrences of MeSH terms.

PubMed

Theodosiou, T; Vizirianakis, I S; Angelis, L; Tsaftaris, A; Darzentas, N

2011-12-01

PubMed is the most widely used database of biomedical literature. To the detriment of the user though, the ranking of the documents retrieved for a query is not content-based, and important semantic information in the form of assigned Medical Subject Headings (MeSH) terms is not readily presented or productively utilized. The motivation behind this work was the discovery of unanticipated information through the appropriate ranking of MeSH term pairs and, indirectly, documents. Such information can be useful in guiding novel research and following promising trends. A web-based tool, called MeSHy, was developed implementing a mainly statistical algorithm. The algorithm takes into account the frequencies of occurrences, concurrences, and the semantic similarities of MeSH terms in retrieved PubMed documents to create MeSH term pairs. These are then scored and ranked, focusing on their unexpectedly frequent or infrequent occurrences. MeSHy presents results through an online interactive interface facilitating further manipulation through filtering and sorting. The results themselves include the MeSH term pairs, along with MeSH categories, the score, and document IDs, all of which are hyperlinked for convenience. To highlight the applicability of the tool, we report the findings of an expert in the pharmacology field on querying the molecularly-targeted drug imatinib and nutrition-related flavonoids. To the best of our knowledge, MeSHy is the first publicly available tool able to directly provide such a different perspective on the complex nature of published work. Implemented in Perl and served by Apache2 at http://bat.ina.certh.gr/tools/meshy/ with all major browsers supported. Copyright © 2011 Elsevier Inc. All rights reserved.

MeWRKY20 and its interacting and activating autophagy-related protein 8 (MeATG8) regulate plant disease resistance in cassava.

PubMed

Yan, Yu; Wang, Peng; He, Chaozu; Shi, Haitao

2017-12-09

As a highly conserved mechanism, autophagy is responsible for the transport of cytoplasmic constituents in the vacuoles or lysosomes. Moreover, autophagy is essential for plant development and various stress responses. In this study, 34 MeATGs were systematically identified in cassava, and their transcripts were commonly regulated by Xanthomonas axonopodis pv manihotis (Xam). Through transient expression in Nicotiana benthamiana, the subcellular locations of 4 MeATG8s were revealed. Notably, MeWRKY20 was identified as physical interacting protein of MeATG8a/8f/8h and upstream transcriptional activator of MeATG8a. Through virus-induced gene silencing (VIGS) in cassava, we found that MeATG8-silenced and MeWRKY20-silenced plants resulted in disease sensitive, with less callose depositions and lower autophagic activity. This study may facilitate our understanding of the upstream MeWRKY20 and underlying target as well as interacting proteins of MeATG8s in immune response. Taken together, MeWRKY20 and MeATG8a/8f/8h are essential for disease resistance against bacterial blight by forming various transcriptional modules and interacting complex in cassava. Copyright © 2017 Elsevier Inc. All rights reserved.

Hong-Ou-Mandel Interference between Two Deterministic Collective Excitations in an Atomic Ensemble

NASA Astrophysics Data System (ADS)

Li, Jun; Zhou, Ming-Ti; Jing, Bo; Wang, Xu-Jie; Yang, Sheng-Jun; Jiang, Xiao; Mølmer, Klaus; Bao, Xiao-Hui; Pan, Jian-Wei

2016-10-01

We demonstrate deterministic generation of two distinct collective excitations in one atomic ensemble, and we realize the Hong-Ou-Mandel interference between them. Using Rydberg blockade we create single collective excitations in two different Zeeman levels, and we use stimulated Raman transitions to perform a beam-splitter operation between the excited atomic modes. By converting the atomic excitations into photons, the two-excitation interference is measured by photon coincidence detection with a visibility of 0.89(6). The Hong-Ou-Mandel interference witnesses an entangled NOON state of the collective atomic excitations, and we demonstrate its two times enhanced sensitivity to a magnetic field compared with a single excitation. Our work implements a minimal instance of boson sampling and paves the way for further multimode and multiexcitation studies with collective excitations of atomic ensembles.

Selective preservation of cholinergic MeCP2 rescues specific Rett-syndrome-like phenotypes in MeCP2stop mice.

PubMed

Zhou, Huanhuan; Wu, Wei; Zhang, Ying; He, Haiyang; Yuan, Zhefeng; Zhu, Zhiwei; Zhao, Zhengyan

2017-03-30

RTT is a neurodevelopmental disorder characterized by growth regression, motor dysfunction, stereotypic hand movements, and autism features. Typical Rett syndrome (RTT) is predominantly caused by mutations in X-linked MeCP2 gene which encodes methyl-CpG-binding protein 2 (MeCP2). The brain-abundant MeCP2 protein mainly functions as a transcriptional regulator for neurodevelopment-associated genes. Specific functions of MeCP2 in certain neuron types remain to be known. Although cholinergic system is an important modulating system in brain, how MeCP2 in cholinergic neurons contribute to RTT has not been clearly understood. Here we use a mouse model with selectively activated endogenous MeCP2 in cholinergic neurons in otherwise MeCP2 stop mice to determine the cholinergic MeCP2 effects on rescuing the RTT-like phenotypes. We found cholinergic MeCP2 preservation could reverse some aspects of the RTT-like phenotypes in mice including hypolocomotion and increased anxiety level, and delay the onset of underweight, instead of improving the hypersocial abnormality and the poor general conditions such as short lifespan, low brain weight, and increasing severity score. Our findings suggest that selective activation of cholinergic MeCP2 is sufficient to reverse the locomotor impairment and increased anxiety-like behaviors at least in early symptomatic stage, supporting future development of RTT therapies associated with cholinergic system. Copyright © 2017 Elsevier B.V. All rights reserved.

Anxiety in children with CFS/ME.

PubMed

Crawley, Esther; Hunt, Linda; Stallard, Paul

2009-11-01

Anxiety symptoms are commonly described in children with chronic fatigue syndrome or myalgic encephalopathy (CFS/ME) but to date there has been little information on the type of anxiety children experience or the relationship between anxiety and school attendance, disability or fatigue. The aim of this study was to first describe the prevalence and type of anxiety symptoms in children with CFS/ME compared with a normal European population, and secondly to investigate the association of anxiety symptoms with age, gender, school attendance, fatigue, and physical function in paediatric CFS/ME. Data were prospectively collected on children and young people with CFS/ME referred to a large specialist CFS/ME service. One hundred and sixty-four children with CFS/ME had complete data for the Spence Children's Anxiety Scale. Teenage girls had the highest rates of total anxiety symptoms with 38% (95% CI 27-49) over the cut off (top 10% of normal European population) and significantly higher rates of symptoms in each subscale. Younger girls were more likely to score over the cut off in separation anxiety (37%, 19-40) and social phobia (39%, 25-47). There was no evidence of association between total anxiety symptoms and: time at school, time to assessment, pain or age. Associations with fatigue and physical function were attenuated when adjusted for other variables. Although anxiety symptoms are high in CFS/ME, particularly in teenage girls, it does not appear to be associated with school attendance or other measures of disability. Separation anxiety and social phobia were the most clearly elevated in paediatric CFS/ME.

Being Active at Child Care. Facilitator's Guide [and Videotape]. Active Me, Healthy Me.

ERIC Educational Resources Information Center

Levenhagen, Kathryn A.

Noting that childhood obesity is a growing concern for parents, educators, and health care providers, this guide and videotape, "Being Active at Child Care," is from a three-part series, "Active Me, Healthy Me," exploring ways to keep children active while in child care settings. The 13-minute videotape demonstrates in both a child care center and…

Water quality assessment of a highly polluted Mediterranean River - Oued Fez (Morocco)

NASA Astrophysics Data System (ADS)

Perrin, J.-L.; Bellarbi, M.; Raïs, N.; Chahinian, N.; Moulin, P.; Ijjaali, M.

2012-04-01

In the South of the Mediterranean basin, many rivers are characterized by an alternation of very long dry periods only cut by short flood events. Currently, the socio-economical development of these zones is limited by water scarcity and poor quality of the water resources. Indeed human activities, generally concentrated in overpopulated cities, generate large quantity of domestic and industrial effluents which are directly rejected in the environment without any treatment. In Morocco, the well known city of Fez illustrates perfectly this situation, observed in most developing countries. The oued Fez receives continuously the non-treated domestic and industrial effluents (90.000 m3/day) of the city and pollutes all the downstream water bodies. Indeed, it is a tributary of the Sebou River, a major body of great economical importance used for irrigation and freshwater supply. This study aims at characterising and quantifying the pollutant concentrations and fluxes in various points of oued Fez's hydrological network and assessing its impact on the Sebou River; this river's preservation being considered a national priority in Morocco. A coupled water quality-water quantity monitoring scheme has been implemented on oued Fez since 2008. In addition to basic hydrological data, water quality samples are collected at regular intervals at 8 locations where discharge is simultaneously measured using an Acoustic Doppler Current Profiler (ADCP). Water samples are analysed for different forms of nitrogen (nitrates, nitrites, ammonium and total nitrogen), phosphorus (soluble reactive phosphorus and total phosphorus) but also total chromium which is used in the leather tanning processes, one of the most important industrial production of the city of Fez, using a photospectrometer (Hach Lange DR 2800 VIS-photometer (Germany). The results of 17 sampling campaigns, carried out over 3 hydrological years, indicate that the rural areas contribute mostly to baseflow during the wet

75 FR 57848 - Revocation of Class E Airspace, Brunswick, ME; and Establishment of Class E Airspace, Wiscasset, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2010-09-23

...-0248; Airspace Docket No. 10-ANE-10] Revocation of Class E Airspace, Brunswick, ME; and Establishment of Class E Airspace, Wiscasset, ME AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Final rule. SUMMARY: This action removes Class E Airspace at Brunswick NAS, Brunswick, ME, as the airport has...

Measurement of the Expansion Proper Motions of the Ou4 Giant Bipolar Outflow to Determine its Distance and its True Nature

NASA Astrophysics Data System (ADS)

Grosso, Nicolas

2016-10-01

Ou4 is a giant bipolar outflow with a total length of 1.2 degrees on the sky that was discovered in the optical in the direction of the blister HII region Sh2-129. The distance, the nature, and the driving source of Ou4 are, however, not known. Ou4 is relevant for the study of the eruptive phenomena producing collimated outflows from evolved low-mass binary stars and young, massive stellar systems. Our morpho-kinematics study of the Ou4 south bow-shock has allowed us to predict its expansion proper motion that is directly related to its distance. We propose to image the brightest [O III] emission of this bow-shock with the UVIS channel of the WFC3 in Cycle 24 and 26 in order to determine the distance of this largest known stellar bipolar outflow from its expansion proper motions. This measurement is crucial to determine the true nature of Ou4: either a foreground planetary nebula or a giant bipolar outflow launched 90,000 years ago by HR 8119, the young massive triple system ionising Sh2-129.

An efficient 14-MeV neutron detector for use in mixed 2. 5- and 14-MeV neutron beams

DOE Office of Scientific and Technical Information (OSTI.GOV)

Croft, S.; Bond, D.S.; Hawkes, N.P.

1993-06-01

A neutron detector capable of measuring the time-dependent yield of 14-MeV neutrons from a D--D plasma producing predominantly 2.5-MeV neutrons has been developed. The detector consists of a thick polythene recoil proton radiator backed by a graphite foil attached to a large area totally depleted ion-implanted diode. Protons scattered in the forward direction by 14-MeV neutrons pass through the graphite foil and are registered in the diode. Recoil protons from 2.5-MeV neutrons, however, are prevented from reaching the diode by the foil. When operated with a 1.5-MeV energy bias, the measured neutron detection efficiency for 15-MeV neutrons is 3.2[times]10[sup [minus]3]more » per neutron. The corresponding figure for 3.1-MeV neutrons is a factor of 540 lower. The neutron detector and its laboratory calibration are described, as is its deployment at the Joint European Torus where it serves as a triton burn-up monitor.« less

Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I)

PubMed Central

Lim, Sze Chern; Carey, Kirstyn T; McKenzie, Matthew

2015-01-01

Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have been widely studied as potential therapies for cancer prevention. The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects, however their specific molecular targets have not been completely defined. To identify these targets, we examined the effects of ME-143 and ME-344 on cellular metabolism and found that they are potent inhibitors of mitochondrial oxidative phosphorylation (OXPHOS) complex I (NADH: ubiquinone oxidoreductase) activity. In isolated HEK293T mitochondria, ME-143 and ME-344 reduced complex I activity to 14.3% and 28.6% of control values respectively. In addition to the inhibition of complex I, ME-344 also significantly inhibited mitochondrial complex III (ubiquinol: ferricytochrome-c oxidoreductase) activity by 10.8%. This inhibition of complex I activity (and to a lesser extent complex III activity) was associated with a reduction in mitochondrial oxygen consumption. In permeabilized HEK293T cells, ME-143 and ME-344 significantly reduced the maximum ADP-stimulated respiration rate to 62.3% and 70.0% of control levels respectively in the presence of complex I-linked substrates. Conversely, complex II-linked respiration was unaffected by either drug. We also observed that the inhibition of complex I-linked respiration caused the dissipation of the mitochondrial membrane potential (ΔΨm). Blue native (BN-PAGE) analysis revealed that prolonged loss of ΔΨm results in the destabilization of the native OXPHOS complexes. In particular, treatment of 143B osteosarcoma, HeLa and HEK293T human embryonic kidney cells with ME-344 for 4 h resulted in reduced steady-state levels of mature complex I. Degradation of the complex I subunit NDUFA9, as well as the complex IV (ferrocytochrome c: oxygen oxidoreductase) subunit COXIV, was also evident. The identification of OXPHOS complex I as a

Anti-cancer analogues ME-143 and ME-344 exert toxicity by directly inhibiting mitochondrial NADH: ubiquinone oxidoreductase (Complex I).

PubMed

Lim, Sze Chern; Carey, Kirstyn T; McKenzie, Matthew

2015-01-01

Isoflavonoids have been shown to inhibit tumor proliferation and metastasis by activating cell death pathways. As such, they have been widely studied as potential therapies for cancer prevention. The second generation synthetic isoflavan analogues ME-143 and ME-344 also exhibit anti-cancer effects, however their specific molecular targets have not been completely defined. To identify these targets, we examined the effects of ME-143 and ME-344 on cellular metabolism and found that they are potent inhibitors of mitochondrial oxidative phosphorylation (OXPHOS) complex I (NADH: ubiquinone oxidoreductase) activity. In isolated HEK293T mitochondria, ME-143 and ME-344 reduced complex I activity to 14.3% and 28.6% of control values respectively. In addition to the inhibition of complex I, ME-344 also significantly inhibited mitochondrial complex III (ubiquinol: ferricytochrome-c oxidoreductase) activity by 10.8%. This inhibition of complex I activity (and to a lesser extent complex III activity) was associated with a reduction in mitochondrial oxygen consumption. In permeabilized HEK293T cells, ME-143 and ME-344 significantly reduced the maximum ADP-stimulated respiration rate to 62.3% and 70.0% of control levels respectively in the presence of complex I-linked substrates. Conversely, complex II-linked respiration was unaffected by either drug. We also observed that the inhibition of complex I-linked respiration caused the dissipation of the mitochondrial membrane potential (ΔΨm). Blue native (BN-PAGE) analysis revealed that prolonged loss of ΔΨm results in the destabilization of the native OXPHOS complexes. In particular, treatment of 143B osteosarcoma, HeLa and HEK293T human embryonic kidney cells with ME-344 for 4 h resulted in reduced steady-state levels of mature complex I. Degradation of the complex I subunit NDUFA9, as well as the complex IV (ferrocytochrome c: oxygen oxidoreductase) subunit COXIV, was also evident. The identification of OXPHOS complex I as a

Molecular identification of GAPDHs in cassava highlights the antagonism of MeGAPCs and MeATG8s in plant disease resistance against cassava bacterial blight.

PubMed

Zeng, Hongqiu; Xie, Yanwei; Liu, Guoyin; Lin, Daozhe; He, Chaozu; Shi, Haitao

2018-06-01

MeGAPCs were identified as negative regulators of plant disease resistance, and the interaction of MeGAPCs and MeATG8s was highlighted in plant defense response. As an important enzyme of glycolysis metabolic pathway, glyceraldehyde-3-P dehydrogenase (GAPDH) plays important roles in plant development, abiotic stress and immune responses. Cassava (Manihot esculenta) is most important tropical crop and one of the major food crops, however, no information is available about GAPDH gene family in cassava. In this study, 14 MeGAPDHs including 6 cytosol GAPDHs (MeGAPCs) were identified from cassava, and the transcripts of 14 MeGAPDHs in response to Xanthomonas axonopodis pv manihotis (Xam) indicated their possible involvement in immune responses. Further investigation showed that MeGAPCs are negative regulators of disease resistance against Xam. Through transient expression in Nicotiana benthamiana, we found that overexpression of MeGAPCs led to decreased disease resistance against Xam. On the contrary, MeGAPCs-silenced cassava plants through virus-induced gene silencing (VIGS) conferred improved disease resistance. Notably, MeGAPCs physically interacted with autophagy-related protein 8b (MeATG8b) and MeATG8e and inhibited autophagic activity. Moreover, MeATG8b and MeATG8e negatively regulated the activities of NAD-dependent MeGAPDHs, and are involved in MeGAPCs-mediated disease resistance. Taken together, this study highlights the involvement of MeGAPCs in plant disease resistance, through interacting with MeATG8b and MeATG8e.

Shade compromises the photosynthetic efficiency of NADP-ME less than that of PEP-CK and NAD-ME C4 grasses.

PubMed

Sonawane, Balasaheb V; Sharwood, Robert E; Whitney, Spencer; Ghannoum, Oula

2018-05-25

The high energy cost and apparently low plasticity of C4 photosynthesis compared with C3 photosynthesis may limit the productivity and distribution of C4 plants in low light (LL) environments. C4 photosynthesis evolved numerous times, but it remains unclear how different biochemical subtypes perform under LL. We grew eight C4 grasses belonging to three biochemical subtypes [NADP-malic enzyme (NADP-ME), NAD-malic enzyme (NAD-ME), and phosphoenolpyruvate carboxykinase (PEP-CK)] under shade (16% sunlight) or control (full sunlight) conditions and measured their photosynthetic characteristics at both low and high light. We show for the first time that LL (during measurement or growth) compromised the CO2-concentrating mechanism (CCM) to a greater extent in NAD-ME than in PEP-CK or NADP-ME C4 grasses by virtue of a greater increase in carbon isotope discrimination (∆P) and bundle sheath CO2 leakiness (ϕ), and a greater reduction in photosynthetic quantum yield (Φmax). These responses were partly explained by changes in the ratios of phosphoenolpyruvate carboxylase (PEPC)/initial Rubisco activity and dark respiration/photosynthesis (Rd/A). Shade induced a greater photosynthetic acclimation in NAD-ME than in NADP-ME and PEP-CK species due to a greater Rubisco deactivation. Shade also reduced plant dry mass to a greater extent in NAD-ME and PEP-CK relative to NADP-ME grasses. In conclusion, LL compromised the co-ordination of the C4 and C3 cycles and, hence, the efficiency of the CCM to a greater extent in NAD-ME than in PEP-CK species, while CCM efficiency was less impacted by LL in NADP-ME species. Consequently, NADP-ME species are more efficient at LL, which could explain their agronomic and ecological dominance relative to other C4 grasses.

Shade compromises the photosynthetic efficiency of NADP-ME less than that of PEP-CK and NAD-ME C4 grasses

PubMed Central

2018-01-01

Abstract The high energy cost and apparently low plasticity of C4 photosynthesis compared with C3 photosynthesis may limit the productivity and distribution of C4 plants in low light (LL) environments. C4 photosynthesis evolved numerous times, but it remains unclear how different biochemical subtypes perform under LL. We grew eight C4 grasses belonging to three biochemical subtypes [NADP-malic enzyme (NADP-ME), NAD-malic enzyme (NAD-ME), and phosphoenolpyruvate carboxykinase (PEP-CK)] under shade (16% sunlight) or control (full sunlight) conditions and measured their photosynthetic characteristics at both low and high light. We show for the first time that LL (during measurement or growth) compromised the CO2-concentrating mechanism (CCM) to a greater extent in NAD-ME than in PEP-CK or NADP-ME C4 grasses by virtue of a greater increase in carbon isotope discrimination (∆P) and bundle sheath CO2 leakiness (ϕ), and a greater reduction in photosynthetic quantum yield (Φmax). These responses were partly explained by changes in the ratios of phosphoenolpyruvate carboxylase (PEPC)/initial Rubisco activity and dark respiration/photosynthesis (Rd/A). Shade induced a greater photosynthetic acclimation in NAD-ME than in NADP-ME and PEP-CK species due to a greater Rubisco deactivation. Shade also reduced plant dry mass to a greater extent in NAD-ME and PEP-CK relative to NADP-ME grasses. In conclusion, LL compromised the co-ordination of the C4 and C3 cycles and, hence, the efficiency of the CCM to a greater extent in NAD-ME than in PEP-CK species, while CCM efficiency was less impacted by LL in NADP-ME species. Consequently, NADP-ME species are more efficient at LL, which could explain their agronomic and ecological dominance relative to other C4 grasses. PMID:29659931

Hey! A Mosquito Bit Me! (For Kids)

MedlinePlus

... Staying Safe Videos for Educators Search English Español Hey! A Mosquito Bit Me! KidsHealth / For Kids / Hey! A Mosquito Bit Me! Print en español ¡Ay! ¡ ... your skin. More on this topic for: Kids Hey! A Flea Bit Me! Hey! A Scorpion Stung ...

The Differences between NAD-ME and NADP-ME Subtypes of C4 Photosynthesis: More than Decarboxylating Enzymes.

PubMed

Rao, Xiaolan; Dixon, Richard A

2016-01-01

As an adaptation to changing climatic conditions that caused high rates of photorespiration, C 4 plants have evolved to display higher photosynthetic efficiency than C 3 plants under elevated temperature, high light intensities, and drought. The C 4 plants independently evolved more than 60 times in 19 families of angiosperms to establish similar but not uniform C 4 mechanisms to concentrate CO 2 around the carboxylating enzyme Rubisco (ribulose bisphosphate carboxylase oxygenase). C 4 photosynthesis is divided into at least two basic biochemical subtypes based on the primary decarboxylating enzymes, NAD-dependent malic enzyme (NAD-ME) and NADP-dependent malic enzyme (NADP-ME). The multiple polygenetic origins of these subtypes raise questions about the association of C 4 variation between biochemical subtypes and diverse lineages. This review addresses the differences in evolutionary scenario, leaf anatomy, and especially C 4 metabolic flow, C 4 transporters, and cell-specific function deduced from recently reported cell-specific transcriptomic, proteomic, and metabolic analyses of NAD-ME and NADP-ME subtypes. Current omic analysis has revealed the extent to which component abundances differ between the two biochemical subtypes, leading to a better understanding of C 4 photosynthetic mechanisms in NAD-ME and NADP-ME subtypes.

The Differences between NAD-ME and NADP-ME Subtypes of C4 Photosynthesis: More than Decarboxylating Enzymes

PubMed Central

Rao, Xiaolan; Dixon, Richard A.

2016-01-01

As an adaptation to changing climatic conditions that caused high rates of photorespiration, C4 plants have evolved to display higher photosynthetic efficiency than C3 plants under elevated temperature, high light intensities, and drought. The C4 plants independently evolved more than 60 times in 19 families of angiosperms to establish similar but not uniform C4 mechanisms to concentrate CO2 around the carboxylating enzyme Rubisco (ribulose bisphosphate carboxylase oxygenase). C4 photosynthesis is divided into at least two basic biochemical subtypes based on the primary decarboxylating enzymes, NAD-dependent malic enzyme (NAD-ME) and NADP-dependent malic enzyme (NADP-ME). The multiple polygenetic origins of these subtypes raise questions about the association of C4 variation between biochemical subtypes and diverse lineages. This review addresses the differences in evolutionary scenario, leaf anatomy, and especially C4 metabolic flow, C4 transporters, and cell-specific function deduced from recently reported cell-specific transcriptomic, proteomic, and metabolic analyses of NAD-ME and NADP-ME subtypes. Current omic analysis has revealed the extent to which component abundances differ between the two biochemical subtypes, leading to a better understanding of C4 photosynthetic mechanisms in NAD-ME and NADP-ME subtypes. PMID:27790235

Polymorphism of the bivalent metal vanadates MeV 2O 6 ( Me = Mg, Ca, Mn, Co, Ni, Cu, Zn, Cd)

NASA Astrophysics Data System (ADS)

Mocała, Krzysztof; Ziółkowski, Jacek

1987-08-01

Based on the literature data, our former findings and additional DTA and high-temperature X-ray studies performed for CdV 2O 6, MgV 2O 6, and MnV 2O 6, a consistent scheme of the phase transformations of the MeV 2O 6 ( Me = Mg, Ca, Mn, Co, Ni, Cu, Zn, Cd) metavanadates is constructed at normal pressure between room temperature and melting points. Three types of structures exist for the considered compounds: brannerite type (B), pseudobrannerite type (P), and NiV 2O 6 type (N). The following phase transformations have been observed: Me = Mg, B → P at 535°C; Me = Mn, B → P at 540°C; Me = Co, N → B at 660°C; Me = Cu, B (with triclinic distortion) → B at 625°C (secondary order); and Me = Cd, B → P at 170°. CaV 2O 6P, NiV 2O 6N, and ZnV 2O 6B exist in unique form in the entire temperature range. P-form seems to be favored by Me of larger ionic radii. N-form seems to appear at a peculiar d-shell structure and small Me size. Preliminary explanation of the dependence of the structure type on Me size is offered. New X-ray data are given for CdV 2O 6B, CdV 2O 6P, MgV 2O 6B, MgV 2O 6P, and MnV 2O 6P.

MeRIP-PF: An Easy-to-use Pipeline for High-resolution Peak-finding in MeRIP-Seq Data

PubMed Central

Li, Yuli; Song, Shuhui; Li, Cuiping; Yu, Jun

2013-01-01

RNA modifications, especially methylation of the N6 position of adenosine (A)—m6A, represent an emerging research frontier in RNA biology. With the rapid development of high-throughput sequencing technology, in-depth study of m6A distribution and function relevance becomes feasible. However, a robust method to effectively identify m6A-modified regions has not been available yet. Here, we present a novel high-efficiency and user-friendly analysis pipeline called MeRIP-PF for the signal identification of MeRIP-Seq data in reference to controls. MeRIP-PF provides a statistical P-value for each identified m6A region based on the difference of read distribution when compared to the controls and also calculates false discovery rate (FDR) as a cut off to differentiate reliable m6A regions from the background. Furthermore, MeRIP-PF also achieves gene annotation of m6A signals or peaks and produce outputs in both XLS and graphical format, which are useful for further study. MeRIP-PF is implemented in Perl and is freely available at http://software.big.ac.cn/MeRIP-PF.html. PMID:23434047

MeRIP-PF: an easy-to-use pipeline for high-resolution peak-finding in MeRIP-Seq data.

PubMed

Li, Yuli; Song, Shuhui; Li, Cuiping; Yu, Jun

2013-02-01

RNA modifications, especially methylation of the N(6) position of adenosine (A)-m(6)A, represent an emerging research frontier in RNA biology. With the rapid development of high-throughput sequencing technology, in-depth study of m(6)A distribution and function relevance becomes feasible. However, a robust method to effectively identify m(6)A-modified regions has not been available yet. Here, we present a novel high-efficiency and user-friendly analysis pipeline called MeRIP-PF for the signal identification of MeRIP-Seq data in reference to controls. MeRIP-PF provides a statistical P-value for each identified m(6)A region based on the difference of read distribution when compared to the controls and also calculates false discovery rate (FDR) as a cut off to differentiate reliable m(6)A regions from the background. Furthermore, MeRIP-PF also achieves gene annotation of m(6)A signals or peaks and produce outputs in both XLS and graphical format, which are useful for further study. MeRIP-PF is implemented in Perl and is freely available at http://software.big.ac.cn/MeRIP-PF.html. Copyright © 2013. Production and hosting by Elsevier Ltd.

MeCP2 regulates ethanol sensitivity and intake.

PubMed

Repunte-Canonigo, Vez; Chen, Jihuan; Lefebvre, Celine; Kawamura, Tomoya; Kreifeldt, Max; Basson, Oan; Roberts, Amanda J; Sanna, Pietro Paolo

2014-09-01

We have investigated the expression of chromatin-regulating genes in the prefrontal cortex and in the shell subdivision of the nucleus accumbens during protracted withdrawal in mice with increased ethanol drinking after chronic intermittent ethanol (CIE) vapor exposure and in mice with a history of non-dependent drinking. We observed that the methyl-CpG binding protein 2 (MeCP2) was one of the few chromatin-regulating genes to be differentially regulated by a history of dependence. As MeCP2 has the potential of acting as a broad gene regulator, we investigated sensitivity to ethanol and ethanol drinking in MeCP2(308/) (Y) mice, which harbor a truncated MeCP2 allele but have a milder phenotype than MeCP2 null mice. We observed that MeCP2(308/) (Y) mice were more sensitive to ethanol's stimulatory and sedative effects than wild-type (WT) mice, drank less ethanol in a limited access 2 bottle choice paradigm and did not show increased drinking after induction of dependence with exposure to CIE vapors. Alcohol metabolism did not differ in MeCP2(308/) (Y) and WT mice. Additionally, MeCP2(308/) (Y) mice did not differ from WT mice in ethanol preference in a 24-hour paradigm nor in their intake of graded solutions of saccharin or quinine, suggesting that the MeCP2(308/) (Y) mutation did not alter taste function. Lastly, using the Gene Set Enrichment Analysis algorithm, we found a significant overlap in the genes regulated by alcohol and by MeCP2. Together, these results suggest that MeCP2 contributes to the regulation of ethanol sensitivity and drinking. © 2013 The Authors, Addiction Biology © 2013 Society for the Study of Addiction.

Always Kiss Me Good Night.

ERIC Educational Resources Information Center

Salt, J. S.

1997-01-01

Presents practical parenting tips obtained from 1,000 children ages 6 to 12 years from a variety of ethnic and economic backgrounds. Common themes included children's desire to receive respect, caring, and guidance from their parents. The most frequent instructions to parents were: "Don't yell at me,""Help me with my homework,"…

Prep-ME Software Implementation and Enhancement

DOT National Transportation Integrated Search

2017-09-01

Highway agencies across the United States are moving from empirical design procedures towards the mechanistic-empirical (ME) based pavement design. Even though the Pavement ME Design presents a new paradigm shift with several dramatic improvements, i...

Syndemics among individuals enrolled in the PrEP Brasil Study.

PubMed

De Boni, Raquel B; Machado, Iona K; De Vasconcellos, Mauricio T L; Hoagland, Brenda; Kallas, Esper G; Madruga, José Valdez; Fernandes, Nilo M; Cerqueira, Natalia B; Moreira, Ronaldo I; Goulart, Silvia P; Veloso, Valdilea G; Grinsztejn, Beatriz; Luz, Paula M

2018-04-01

Concurrent psychosocial problems may synergistically increase the risk of HIV infection (syndemics), representing a challenge for prevention. We aimed to evaluate the prevalence and associated factors of syndemics among men who have sex with men (MSM) and transgender women (TGW) enrolled in the Brazilian pre-exposure prophylaxis demonstration study (PrEP Brasil Study). Secondary cross-sectional analysis of the PrEP Brasil Study was performed. Of 450 HIV-seronegative MSM/TGW enrolled in the PrEP Brasil Study- conducted at Rio de Janeiro and São Paulo, Brazil- 421 participants with complete data were included in the present analysis. Syndemics was defined as occurrence of ≥2 of the following conditions: polysubstance (≥2) use, binge drinking, positive depression screen, compulsive sexual behavior, and intimate partner violence (IPV). The prevalence of recent polysubstance use was 22.8%, binge drinking 51.1%, positive depression screening 5.2%, compulsive sexual behavior 7.1%, and IPV 7.3%. Syndemics prevalence was 24.2%, and associated factors were younger age (adjusted Odds Ratio (aOR) 0.95, 95% Confidence Interval (95% CI) 0.92-0.98 per year increase), TGW vs. MSM (aOR 3.09, 95% CI: 1.2-8.0), some college education or more vs. less than college (aOR 2.49, 95% CI: 1.31-4.75), and multiple male sexual partners in prior 3 months (aOR 1.69, 95% CI: 0.92-3.14). Given the high prevalence of syndemics, particularly of polysubstance use and binge drinking, PrEP delivery offers an opportunity to diagnose and intervene in mental and social well-being. Copyright © 2018 Elsevier B.V. All rights reserved.

Rett syndrome and MeCP2.

PubMed

Liyanage, Vichithra R B; Rastegar, Mojgan

2014-06-01

Rett syndrome (RTT) is a severe and progressive neurological disorder, which mainly affects young females. Mutations of the methyl-CpG binding protein 2 (MECP2) gene are the most prevalent cause of classical RTT cases. MECP2 mutations or altered expression are also associated with a spectrum of neurodevelopmental disorders such as autism spectrum disorders with recent links to fetal alcohol spectrum disorders. Collectively, MeCP2 relation to these neurodevelopmental disorders highlights the importance of understanding the molecular mechanisms by which MeCP2 impacts brain development, mental conditions, and compromised brain function. Since MECP2 mutations were discovered to be the primary cause of RTT, a significant progress has been made in the MeCP2 research, with respect to the expression, function and regulation of MeCP2 in the brain and its contribution in RTT pathogenesis. To date, there have been intensive efforts in designing effective therapeutic strategies for RTT benefiting from mouse models and cells collected from RTT patients. Despite significant progress in MeCP2 research over the last few decades, there is still a knowledge gap between the in vitro and in vivo research findings and translating these findings into effective therapeutic interventions in human RTT patients. In this review, we will provide a synopsis of Rett syndrome as a severe neurological disorder and will discuss the role of MeCP2 in RTT pathophysiology.

Validation of the MISSCARE-BRASIL survey - A tool to assess missed nursing care.

PubMed

Siqueira, Lillian Dias Castilho; Caliri, Maria Helena Larcher; Haas, Vanderlei José; Kalisch, Beatrice; Dantas, Rosana Aparecida Spadoti

2017-12-21

to analyze the metric validity and reliability properties of the MISSCARE-BRASIL survey. methodological research conducted by assessing construct validity and reliability via confirmatory factor analysis, known-groups validation, convergent construct validation, analysis of internal consistency and test-retest reliability. The sample consisted of 330 nursing professionals, of whom 86 participated in the retest phase. of the 330 participants, 39.7% were aides, 33% technicians, 20.9% nurses, and 6.4% nurses with administrative roles. Confirmatory factorial analysis demonstrated that the Brazilian Portuguese version of the instrument is adequately adjusted to the dimensional structure the scale authors originally proposed. The correlation between "satisfaction with position/role" and "satisfaction with teamwork" and the survey's missed care variables was moderate (Spearman's coefficient =0.35; p<0.001). The results of the Student's t-test indicated known-group validity. Professionals from closed units reported lower levels of missed care in comparison with the other units. The reliability showed a strong correlation, with the exception of "institutional management/leadership style" (intraclass correlation coefficient (ICC)=0.15; p=0.04). The internal consistency was adequate (Cronbach's alpha was greater than 0.70). the MISSCARE-BRASIL was valid and reliable in the group studied. The application of the MISSCARE-BRASIL can contribute to identifying solutions for missed nursing care.

Absolute parameters and chemical composition of the binary star OU Gem

NASA Astrophysics Data System (ADS)

Glazunova, L. V.; Mishenina, T. V.; Soubiran, C.; Kovtyukh, V. V.

2014-10-01

The absolute parameters and chemical composition of the BY Dra-type spectroscopic binary OU Gem (HD 45088) were determined on the basis of 10 high-resolution spectra. A new orbital solution of the binary system was determined, the binary ephemerides were specified, and the main physical and atmospheric parameters of the binary components were obtained. The chemical composition of both components was estimated for the first time for the stars of such type.

Expanding the Chemistry of Actinide Metallocene Bromides. Synthesis, Properties and Molecular Structures of the Tetravalent and Trivalent Uranium Bromide Complexes: (C 5Me 4R) 2UBr 2, (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(Br), and [K(THF)][(C 5Me 4R) 2UBr 2] (R = Me, Et)

DOE Office of Scientific and Technical Information (OSTI.GOV)

Lichtscheidl, Alejandro Gaston; Pagano, Justin K.; Scott, Brian Lindley

The organometallic uranium species (C 5Me 4R) 2UBr 2 (R = Me, Et) were obtained by treating their chloride analogues (C 5Me 4R) 2UCl 2 (R = Me, Et) with Me 3SiBr. Treatment of (C 5Me 4R) 2UCl 2 and (C 5Me 4R) 2UBr 2 (R = Me, Et) with K(O-2,6- iPr 2C 6H 3) afforded the halide aryloxide mixed-ligand complexes (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(X) (R = Me, Et; X = Cl, Br). Complexes (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(Br) (R = Me, Et) can also be synthesized by treating (C 5Me 4R) 2U(O-2,6-more » iPr 2C 6H 3)(Cl) (R = Me, Et) with Me 3SiBr, respectively. Reduction of (C 5Me 4R) 2UCl 2 and (C 5Me 4R) 2UBr 2 (R = Me, Et) with KC 8 led to isolation of uranium(III) “ate” species [K(THF)][(C 5Me 5) 2UX 2] (X = Cl, Br) and [K(THF) 0.5][(C 5Me 4Et) 2UX 2] (X = Cl, Br), which can be converted to the neutral complexes (C 5Me 4R) 2U[N(SiMe 3) 2] (R = Me, Et). Analyses by nuclear magnetic resonance spectroscopy, X-ray crystallography, and elemental analysis are also presented.« less

Expanding the Chemistry of Actinide Metallocene Bromides. Synthesis, Properties and Molecular Structures of the Tetravalent and Trivalent Uranium Bromide Complexes: (C 5Me 4R) 2UBr 2, (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(Br), and [K(THF)][(C 5Me 4R) 2UBr 2] (R = Me, Et)

DOE PAGES

Lichtscheidl, Alejandro Gaston; Pagano, Justin K.; Scott, Brian Lindley; ...

2016-01-06

The organometallic uranium species (C 5Me 4R) 2UBr 2 (R = Me, Et) were obtained by treating their chloride analogues (C 5Me 4R) 2UCl 2 (R = Me, Et) with Me 3SiBr. Treatment of (C 5Me 4R) 2UCl 2 and (C 5Me 4R) 2UBr 2 (R = Me, Et) with K(O-2,6- iPr 2C 6H 3) afforded the halide aryloxide mixed-ligand complexes (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(X) (R = Me, Et; X = Cl, Br). Complexes (C 5Me 4R) 2U(O-2,6- iPr 2C 6H 3)(Br) (R = Me, Et) can also be synthesized by treating (C 5Me 4R) 2U(O-2,6-more » iPr 2C 6H 3)(Cl) (R = Me, Et) with Me 3SiBr, respectively. Reduction of (C 5Me 4R) 2UCl 2 and (C 5Me 4R) 2UBr 2 (R = Me, Et) with KC 8 led to isolation of uranium(III) “ate” species [K(THF)][(C 5Me 5) 2UX 2] (X = Cl, Br) and [K(THF) 0.5][(C 5Me 4Et) 2UX 2] (X = Cl, Br), which can be converted to the neutral complexes (C 5Me 4R) 2U[N(SiMe 3) 2] (R = Me, Et). Analyses by nuclear magnetic resonance spectroscopy, X-ray crystallography, and elemental analysis are also presented.« less

Synthesis and reactivity of bis(tetramethylcyclopentadienyl) yttrium metallocenes including the reduction of Me(3)SiN(3) to [(Me(3)Si)(2)N](-) with [(C(5)Me(4)H)(2)Y(THF)](2)(mu-eta(2):eta(2)-N(2)).

PubMed

Lorenz, Sara E; Schmiege, Benjamin M; Lee, David S; Ziller, Joseph W; Evans, William J

2010-07-19

The metallocene precursors needed to provide the tetramethylcyclopentadienyl yttrium complexes (C(5)Me(4)H)(3)Y, [(C(5)Me(4)H)(2)Y(THF)](2)(mu-eta(2):eta(2)-N(2)), and [(C(5)Me(4)H)(2)Y(mu-H)](2) for reactivity studies have been synthesized and fully characterized, and their reaction chemistry has led to an unexpected conversion of an azide to an amide. (C(5)Me(4)H)(2)Y(mu-Cl)(2)K(THF)(x), 1, synthesized from YCl(3) and KC(5)Me(4)H reacts with allylmagnesium chloride to make (C(5)Me(4)H)(2)Y(eta(3)-C(3)H(5)), 2, which is converted to [(C(5)Me(4)H)(2)Y][(mu-Ph)(2)BPh(2)], 3, with [Et(3)NH][BPh(4)]. Complex 3 reacts with KC(5)Me(4)H to form (C(5)Me(4)H)(3)Y, 4. The reduced dinitrogen complex, [(C(5)Me(4)H)(2)Y(THF)](2)(mu-eta(2):eta(2)-N(2)), 5, can be synthesized from either [(C(5)Me(4)H)(2)Y](2)[(mu-Ph)(2)BPh(2)], 3, or (C(5)Me(4)H)(3)Y, 4, with potassium graphite under a dinitrogen atmosphere. The (15)N labeled analogue, [(C(5)Me(4)H)(2)Y(THF)](2)(mu-eta(2):eta(2)-(15)N(2)), 5-(15)N, has also been prepared, and the (15)N NMR data have been compared to previously characterized reduced dinitrogen complexes. Complex 2 reacts with H(2) to form the corresponding hydride, [(C(5)Me(4)H)(2)Y(mu-H)](2), 6. Complex 5 displays similar reactivity to that of the analogous [(C(5)Me(4)H)(2)Ln(THF)](2)(mu-eta(2):eta(2)-N(2)) complexes (Ln = La, Lu), with substrates such as phenazine, anthracene, and CO(2). In addition, 5 reduces Me(3)SiN(3) to form (C(5)Me(4)H)(2)Y[N(SiMe(3))(2)], 7.

Solar Gamma Rays Above 8 MeV

NASA Technical Reports Server (NTRS)

Crannell, C. J.; Crannell, H.; Ramaty, R.

1978-01-01

Processes which lead to the production of gamma rays with energy greater than 8 MeV in solar flares are reviewed and evaluated. Excited states produced by inelastic scattering, charge exchange, and spallation reactions in the abundant nuclear species are considered in order to identify nuclear lines which may contribute to the Gamma ray spectrum of solar flares. The flux of 15.11 MeV Gamma rays relative to the flux of 4.44 MeV Gamma rays from the de-excitation of the corresponding states in C12 is calculated for a number of assumed distributions of exciting particles. This flux ratio is a sensitive diagnostic of accelerated particle spectra. Other high energy nuclear levels are not so isolated as the 15.11 MeV state and are not expected to be so strong. The spectrum of Gamma rays from the decay of Pi dey is sensitive to the energy distribution of particles accelerated to energies greater than 100 MeV.

X-ray diving in the center of Sh2-129: looking for the driving source of Ou4

NASA Astrophysics Data System (ADS)

Grosso, Nicolas

2012-10-01

The outflow phenomenon is associated both with the early and the last phase of the stellar evolution. Recently, a unique bipolar outflow with an angular size of 1.2 degrees was discovered in the blister HII region Sh2-129. Ou4, nicknamed "The Giant Squid", is to our knowledge the bipolar outflow with the largest angular size ever found. We propose joint XMM-Newton/EPIC (35 ks) and Chandra/HRC-I (16 ks) observations to look for the driving source of Ou4 and to clarify the nature of this object.

Fly Me to the Moon

NASA Image and Video Library

2018-01-24

Human spaceflight inspires humans to create art, in many forms—a collection of fiber art quilts entitled Fly Me To The Moon has been touring the country since late 2016 with more stops on the schedule. A group of those quilts was displayed at NASA’s Johnson Space Center in Houston a year ago in recognition of the 50th anniversary of the Apollo 1 fire; curator Susanne Jones comments on the artistic elements of some of the pieces as well as the educational value of the exhibit to a nation inspired by space exploration. For more on the collection: http://www.susannemjones.com/fly-me-to-the-moon/ For more on Apollo: www.nasa.gov/apollo HD Download: https://archive.org/details/jsc2017m000324_Fly_Me_to_the_Moon

Caracterisation des proprietes acoustiques des materiaux poreux a cellules ouvertes et a matrice rigide ou souple

NASA Astrophysics Data System (ADS)

Salissou, Yacoubou

L'objectif global vise par les travaux de cette these est d'ameliorer la caracterisation des proprietes macroscopiques des materiaux poreux a structure rigide ou souple par des approches inverses et indirectes basees sur des mesures acoustiques faites en tube d'impedance. La precision des approches inverses et indirectes utilisees aujourd'hui est principalement limitee par la qualite des mesures acoustiques obtenues en tube d'impedance. En consequence, cette these se penche sur quatre problemes qui aideront a l'atteinte de l'objectif global precite. Le premier probleme porte sur une caracterisation precise de la porosite ouverte des materiaux poreux. Cette propriete en est une de passage permettant de lier la mesure des proprietes dynamiques acoustiques d'un materiau poreux aux proprietes effectives de sa phase fluide decrite par les modeles semi-phenomenologiques. Le deuxieme probleme traite de l'hypothese de symetrie des materiaux poreux selon leur epaisseur ou un index et un critere sont proposes pour quantifier l'asymetrie d'un materiau. Cette hypothese est souvent source d'imprecision des methodes de caracterisation inverses et indirectes en tube d'impedance. Le critere d'asymetrie propose permet ainsi de s'assurer de l'applicabilite et de la precision de ces methodes pour un materiau donne. Le troisieme probleme vise a mieux comprendre le probleme de transmission sonore en tube d'impedance en presentant pour la premiere fois un developpement exact du probleme par decomposition d'ondes. Ce developpement permet d'etablir clairement les limites des nombreuses methodes existantes basees sur des tubes de transmission a 2, 3 ou 4 microphones. La meilleure comprehension de ce probleme de transmission est importante puisque c'est par ce type de mesures que des methodes permettent d'extraire successivement la matrice de transfert d'un materiau poreux et ses proprietes dynamiques intrinseques comme son impedance caracteristique et son nombre d'onde complexe. Enfin, le

Respostas religiosas à aids no Brasil: impressões de pesquisa1

PubMed Central

Seffner, Fernando; da Silva, Cristiane Gonçalves Meireles; Maksud, Ívia; Garcia, Jonathan; Rios, Luís Felipe; Natividade, Marcelo; Borges, Priscila Rodrigues; Parker, Richard; Terto, Veriano

2009-01-01

Resumo O texto encontra-se estruturado em quatro partes. Na primeira delas, apresentamos um conjunto de considerações e informações acerca da situação da aids no Brasil, das relações entre religião, sexualidade, aids e estado laico, bem como uma descrição mais clara do Projeto Respostas Religiosas ao HIV/Aids no Brasil, do qual este texto apresenta algumas impressões de pesquisa preliminares. A seguir, dedicamos um item a apresentação da Pastoral de DST/Aids, sua história, estrutura e objetivos. No item seguinte problematizamos diversas questões em particular no âmbito das relações Estado e Igreja, relações entre agentes de pastoral e hierarquia da Igreja, e questões ligadas mais diretamente à sexualidade e aids, todas referenciadas ao trabalho da Pastoral de DST/Aids. Ao final, apresentamos a bibliografia e fontes consultadas. PMID:20428503

Anxiety and depression in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME): Examining the incidence of health anxiety in CFS/ME.

PubMed

Daniels, Jo; Brigden, Amberly; Kacorova, Adela

2017-09-01

There is a lack of research examining the incidence of health anxiety in chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME), despite this being an important research area with potentially significant clinical implications. This preliminary study aimed to determine the incidence of anxiety and depression, more specifically health anxiety, in a sample of CFS/ME patients over a 3-month period. The research was a cross-sectional questionnaire-based study, using a consecutive sample of patients who were assessed in a CFS/ME service. Data were taken from the Short Health Anxiety Inventory and the Hospital Anxiety and Depression Scale to identify incidence of anxiety, depression, and health anxiety. Data were collected from 45 CFS/ME patients over the sampling period. Thirty-one patients (68.9%) scored above the normal range but within the subclinical range of health anxiety, and 19 patients (42.2%) scored within the clinically significant health anxiety range. Anxiety and depression were common, with prevalence rates of 42.2% and 33.3% respectively, which is comparable to data found in a recent large-scale trial. Health anxiety in CFS/ME patients is likely to be common and warrants further investigation to provide a better insight into how this may influence treatment and symptom management. Anxiety and depression were common in a sample of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) patients, with a high proportion meeting criteria for severe health anxiety. While CFS/ME and health anxiety are distinct and separate conditions, it is unsurprising that patients with CFS/ME, who commonly report feeling 'delegitimized', may experience high levels of anxiety relating to their physical symptoms. Clinicians should consider screening for health anxiety due to the possible clinical implications for treatment; mutual maintenance may negatively influence treatment success in a complex condition such as CFS/ME. Health anxiety has been found to be common

Spatial two-photon interference in a Hong-Ou-Mandel interferometer

DOE Office of Scientific and Technical Information (OSTI.GOV)

Kim, Heonoh; Kwon, Osung; Kim, Wonsik

2006-02-15

We report the observation of the cosine modulation in the coincidence rates from a Hong-Ou-Mandel (HOM) interferometer. Spatial interference fringes are seen by minute rotations of one mirror about the vertical axis, while the beam splitter is fixed in the center position. The results show that the maximum visibility of the fringe is 0.81, and the photon pairs separated by less than 1.52 mm in the source plane are measured to be indistinguishable. It turns out that it is possible to invert the HOM dips to peaks by the rotation of the mirror.

Hong-Ou-Mandel Interference with a Single Atom.

PubMed

Ralley, K A; Lerner, I V; Yurkevich, I V

2015-09-14

The Hong-Ou-Mandel (HOM) effect is widely regarded as the quintessential quantum interference phenomenon in optics. In this work we examine how nonlinearity can smear statistical photon bunching in the HOM interferometer. We model both the nonlinearity and a balanced beam splitter with a single two-level system and calculate a finite probability of anti-bunching arising in this geometry. We thus argue that the presence of such nonlinearity would reduce the visibility in the standard HOM setup, offering some explanation for the diminution of the HOM visibility observed in many experiments. We use the same model to show that the nonlinearity affects a resonant two-photon propagation through a two-level impurity in a waveguide due to a "weak photon blockade" caused by the impossibility of double-occupancy and argue that this effect might be stronger for multi-photon propagation.

A Formative Evaluation of CU-SeeMe.

DTIC Science & Technology

1995-02-01

CU- SeeMe is a video conferencing software package that was designed and programmed at Cornell University. The program works with the TCP/IP network...protocol and allows two or more parties to conduct a real-time video conference with full audio support. In this paper we evaluate CU- SeeMe through...caused the problem and why This helps in the process of formulating solutions for observed usability problems. All the testing results are combined in the Appendix in an illustrated partial redesign of the CU- SeeMe Interface.

Robin Wood, "Rio Bravo," and Me

ERIC Educational Resources Information Center

Leith, Dick

2011-01-01

The film scholar Robin Wood, who died recently, taught me English during the mid-1960s at Welwyn Garden City High School (now Sir Frederick Osborn Comprehensive). He was one of those teachers who "made a difference". He helped me learn that it was all right for a boy from a working-class home to study stuff such as literature. But it was…

Frequency-domain Hong-Ou-Mandel interference with linear optics.

PubMed

Imany, Poolad; Odele, Ogaga D; Alshaykh, Mohammed S; Lu, Hsuan-Hao; Leaird, Daniel E; Weiner, Andrew M

2018-06-15

The Hong-Ou-Mandel (HOM) interference is one of the most fundamental quantum-mechanical effects that reveal a nonclassical behavior of single photons. Two identical photons that are incident on the input ports of an unbiased beam splitter always exit the beam splitter together from the same output port, an effect referred to as photon bunching. In this Letter, we utilize a single electro-optic phase modulator as a probabilistic frequency beam splitter, which we exploit to observe HOM interference between two photons that are in different spectral modes, yet are identical in other characteristics. Our approach enables linear optical quantum information processing protocols using the frequency degree of freedom in photons such as quantum computing techniques with linear optics.

Direct observation of phase-sensitive Hong-Ou-Mandel interference

NASA Astrophysics Data System (ADS)

Marek, Petr; Zapletal, Petr; Filip, Radim; Hashimoto, Yosuke; Toyama, Takeshi; Yoshikawa, Jun-ichi; Makino, Kenzo; Furusawa, Akira

2017-09-01

The quality of individual photons and their ability to interfere are traditionally tested by measuring the Hong-Ou-Mandel photon bunching effect. However, this phase-insensitive measurement only tests the particle aspect of the quantum interference, leaving out the phase-sensitive aspects relevant for continuous-variable processing. To overcome these limitations we formulate a witness capable of recognizing both the indistinguishability of the single photons and their quality with regard to their continuous-variable utilization. We exploit the conditional nonclassical squeezing and show that it can reveal both the particle and the wave aspects of the quantum interference in a single set of direct measurements. We experimentally test the witness by applying it to a pair of independent single photons retrieved on demand.

Hong-Ou-Mandel interference of entangled Hermite-Gauss modes

NASA Astrophysics Data System (ADS)

Zhang, Yingwen; Prabhakar, Shashi; Rosales-Guzmán, Carmelo; Roux, Filippus S.; Karimi, Ebrahim; Forbes, Andrew

2016-09-01

Hong-Ou-Mandel (HOM) interference is demonstrated experimentally for entangled photon pairs in the Hermite-Gauss (HG) basis. We use two Dove prisms in one of the paths of the photons to manipulate the entangled quantum state that enters the HOM interferometer. It is demonstrated that, when entangled photon pairs are in a symmetric Bell state in the Laguerre-Gauss (LG) basis, they will remain symmetric after decomposing them into the HG basis, thereby resulting in no coincidence events after the HOM interference. On the other hand, if the photon pairs are in an antisymmetric Bell state in the LG basis, then they will also be antisymmetric in the HG basis, thereby producing only coincidence events as a result of the HOM interference.

The HyMeX database

NASA Astrophysics Data System (ADS)

Brissebrat, Guillaume; Mastrorillo, Laurence; Ramage, Karim; Boichard, Jean-Luc; Cloché, Sophie; Fleury, Laurence; Klenov, Ludmila; Labatut, Laurent; Mière, Arnaud

2013-04-01

The international HyMeX (HYdrological cycle in the Mediterranean EXperiment) project aims at a better understanding and quantification of the hydrological cycle and related processes in the Mediterranean, with emphasis on high-impact weather events, inter-annual to decadal variability of the Mediterranean coupled system, and associated trends in the context of global change. The project includes long term monitoring of environmental parameters, intensive field campaigns, use of satellite data, modelling studies, as well as post event field surveys and value-added products processing. Therefore HyMeX database incorporates various dataset types from different disciplines, either operational or research. The database relies on a strong collaboration between OMP and IPSL data centres. Field data, which are 1D time series, maps or pictures, are managed by OMP team while gridded data (satellite products, model outputs, radar data...) are managed by IPSL team. At present, the HyMeX database contains about 150 datasets, including 80 hydrological, meteorological, ocean and soil in situ datasets, 30 radar datasets, 15 satellite products, 15 atmosphere, ocean and land surface model outputs from operational (re-)analysis or forecasts and from research simulations, and 5 post event survey datasets. The data catalogue complies with international standards (ISO 19115; INSPIRE; Directory Interchange Format; Global Change Master Directory Thesaurus). It includes all the datasets stored in the HyMeX database, as well as external datasets relevant for the project. All the data, whatever the type is, are accessible through a single gateway. The database website http://mistrals.sedoo.fr/HyMeX offers different tools: - A registration procedure which enables any scientist to accept the data policy and apply for a user database account. - A search tool to browse the catalogue using thematic, geographic and/or temporal criteria. - Sorted lists of the datasets by thematic keywords, by

40 CFR 721.10262 - Oxime, Me vinyl silane (generic).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Oxime, Me vinyl silane (generic). 721... Substances § 721.10262 Oxime, Me vinyl silane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as oxime, Me vinyl silane (PMN P...

40 CFR 721.10262 - Oxime, Me vinyl silane (generic).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Oxime, Me vinyl silane (generic). 721... Substances § 721.10262 Oxime, Me vinyl silane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as oxime, Me vinyl silane (PMN P...

Recent advances in MeCP2 structure and function1

PubMed Central

Hite, Kristopher C.; Adams, Valerie H.; Hansen, Jeffrey C.

2010-01-01

Mutations in methyl DNA binding protein 2 (MeCP2) cause the neurodevelopmental disorder Rett syndrome (RTT). The mechanism(s) by which the native MeCP2 protein operates in the cell are not well understood. Historically, MeCP2 has been characterized as a proximal gene silencer with 2 functional domains: a methyl DNA binding domain and a transcription repression domain. However, several lines of new data indicate that MeCP2 structure and function relationships are more complex. In this review, we first discuss recent studies that have advanced understanding of the basic structural biochemistry of MeCP2. This is followed by an analysis of cell-based experiments suggesting MeCP2 is a regulator, rather than a strict silencer, of transcription. The new data establish MeCP2 as a multifunctional nuclear protein, with potentially important roles in chromatin architecture, regulation of RNA splicing, and active transcription. We conclude by discussing clinical correlations between domain-specific mutations and RTT pathology to stress that all structural domains of MeCP2 are required to properly mediate cellular function of the intact protein. PMID:19234536

[Immunopathogenesis of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)].

PubMed

Yamamura, Takashi; Ono, Hirohiko; Sato, Wakiro

2018-01-01

A recent study on the pathogenesis of myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) has revealed an elevation of inflammatory and anti-inflammatory cytokines in the sera and cerebrospinal fluids of the patients and presence of autoantibodies in subgroups of ME/CFS patients. Furthermore, investigator-initiated clinical trials have proved the efficacy of anti-CD20 antibody (rituximab), that eliminate B cells, in the treatment of ME/CFS. Based on these findings, we hypothesize that immune abnormalities, such as enhanced autoimmune responses, may play an essential role in the neuroinflammatory pathogenesis of ME/CFS.

New Sulfide Compounds MeXMn1-XS (Me=3d Metal) with the Colossal Magnetoresistance Effect

DTIC Science & Technology

2006-05-19

is to synthesize the new MeXMn1-XS (Me=3d-metal) sulfide compounds and to study the electrical, magnetic and magnetoresistive properties . Recently...oxide compounds of manganese (LaMnO3-type) with perovskite structure have been intensively investigated. This interest is caused by the observation of... properties of the materials with different structure. It is known that alpha - MnS manganese monosulfide, similar to LaMnO3, has the specific

40 CFR 721.10261 - Oxime, di-Me silane (generic).

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 32 2013-07-01 2013-07-01 false Oxime, di-Me silane (generic). 721... Substances § 721.10261 Oxime, di-Me silane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as oxime, di-Me silane (PMN P-09-589...

40 CFR 721.10261 - Oxime, di-Me silane (generic).

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 32 2012-07-01 2012-07-01 false Oxime, di-Me silane (generic). 721... Substances § 721.10261 Oxime, di-Me silane (generic). (a) Chemical substance and significant new uses subject to reporting. (1) The chemical substance identified generically as oxime, di-Me silane (PMN P-09-589...

MeSH-informed enrichment analysis and MeSH-guided semantic similarity among functional terms and gene products in chicken

USDA-ARS?s Scientific Manuscript database

Such Biomedical vocabularies and ontologies aid in recapitulating biological knowledge. The annotation of gene products is mainly accelerated by Gene Ontology (GO) and more recently by Medical Subject Headings (MeSH). MeSH is the National Library of Medicine's controlled vocabulary and it is making ...

Methylmercury (MeHg)

Integrated Risk Information System (IRIS)

Methylmercury ( MeHg ) ; CASRN 22967 - 92 - 6 Human health assessment information on a chemical substance is included in the IRIS database only after a comprehensive review of toxicity data , as outlined in the IRIS assessment development process . Sections I ( Health Hazard Assessments for Noncarci

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia

PubMed Central

Jeyaraju, Danny V.; Hurren, Rose; Wang, Xiaoming; MacLean, Neil; Gronda, Marcela; Shamas-Din, Aisha; Minden, Mark D.; Giaever, Guri; Schimmer, Aaron D.

2016-01-01

The isoflavone ME-344 is a potent anti-cancer agent with preclinical and clinical efficacy in solid tumors. Yet, the mechanism of action of ME-344 has not been fully defined and the preclinical efficacy in leukemia has not been established. Therefore, we investigated the anti-leukemic properties and mechanism of action of ME-344. In a panel of 7 leukemia cell lines, ME-344 was cytotoxic with an IC50 in the range of 70–260 nM. In addition, ME-344 was cytotoxic to primary AML patient samples over normal hematopoietic cells. In an OCI-AML2 xenograft model, ME-344 reduced tumor growth by up to 95% of control without evidence of toxicity. Mechanistically, ME-344 increased mitochondrial ROS generation in leukemic cells. However, antioxidant treatment did not rescue cell death, suggesting that ME-344 had additional targets beyond the mitochondria. We demonstrated that ME-344 inhibited tubulin polymerization by interacting with tubulin near the colchicine-binding site. Furthermore, inhibition of tubulin polymerization was functionally important for ME-344 induced death. Finally, we showed that ME-344 synergizes with vinblastine in leukemia cells. Thus, our study demonstrates that ME-344 displays preclinical efficacy in leukemia through a mechanism at least partly related to targeting tubulin polymerization. PMID:27391350

A novel isoflavone, ME-344, targets the cytoskeleton in acute myeloid leukemia.

PubMed

Jeyaraju, Danny V; Hurren, Rose; Wang, Xiaoming; MacLean, Neil; Gronda, Marcela; Shamas-Din, Aisha; Minden, Mark D; Giaever, Guri; Schimmer, Aaron D

2016-08-02

The isoflavone ME-344 is a potent anti-cancer agent with preclinical and clinical efficacy in solid tumors. Yet, the mechanism of action of ME-344 has not been fully defined and the preclinical efficacy in leukemia has not been established. Therefore, we investigated the anti-leukemic properties and mechanism of action of ME-344. In a panel of 7 leukemia cell lines, ME-344 was cytotoxic with an IC50 in the range of 70-260 nM. In addition, ME-344 was cytotoxic to primary AML patient samples over normal hematopoietic cells. In an OCI-AML2 xenograft model, ME-344 reduced tumor growth by up to 95% of control without evidence of toxicity. Mechanistically, ME-344 increased mitochondrial ROS generation in leukemic cells. However, antioxidant treatment did not rescue cell death, suggesting that ME-344 had additional targets beyond the mitochondria. We demonstrated that ME-344 inhibited tubulin polymerization by interacting with tubulin near the colchicine-binding site. Furthermore, inhibition of tubulin polymerization was functionally important for ME-344 induced death. Finally, we showed that ME-344 synergizes with vinblastine in leukemia cells. Thus, our study demonstrates that ME-344 displays preclinical efficacy in leukemia through a mechanism at least partly related to targeting tubulin polymerization.

33 CFR 80.110 - Casco Bay, ME.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Casco Bay, ME. 80.110 Section 80.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.110 Casco Bay, ME. (a) A line drawn from the...

33 CFR 80.110 - Casco Bay, ME.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Casco Bay, ME. 80.110 Section 80.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.110 Casco Bay, ME. (a) A line drawn from the...

7 CFR 275.20 - ME review schedules.

Code of Federal Regulations, 2010 CFR

2010-01-01

... 7 Agriculture 4 2010-01-01 2010-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

7 CFR 275.20 - ME review schedules.

Code of Federal Regulations, 2012 CFR

2012-01-01

... 7 Agriculture 4 2012-01-01 2012-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

7 CFR 275.20 - ME review schedules.

Code of Federal Regulations, 2011 CFR

2011-01-01

... 7 Agriculture 4 2011-01-01 2011-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

7 CFR 275.20 - ME review schedules.

Code of Federal Regulations, 2013 CFR

2013-01-01

... 7 Agriculture 4 2013-01-01 2013-01-01 false ME review schedules. 275.20 Section 275.20 Agriculture Regulations of the Department of Agriculture (Continued) FOOD AND NUTRITION SERVICE, DEPARTMENT OF AGRICULTURE... Program Performance § 275.20 ME review schedules. (a) Each State agency shall submit its review schedule...

33 CFR 80.110 - Casco Bay, ME.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Casco Bay, ME. 80.110 Section 80.110 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY INTERNATIONAL NAVIGATION RULES COLREGS DEMARCATION LINES Atlantic Coast § 80.110 Casco Bay, ME. (a) A line drawn from the...

Comparison and combination of several MeSH indexing approaches

PubMed Central

Yepes, Antonio Jose Jimeno; Mork, James G.; Demner-Fushman, Dina; Aronson, Alan R.

2013-01-01

MeSH indexing of MEDLINE is becoming a more difficult task for the group of highly qualified indexing staff at the US National Library of Medicine, due to the large yearly growth of MEDLINE and the increasing size of MeSH. Since 2002, this task has been assisted by the Medical Text Indexer or MTI program. We extend previous machine learning analysis by adding a more diverse set of MeSH headings targeting examples where MTI has been shown to perform poorly. Machine learning algorithms exceed MTI’s performance on MeSH headings that are used very frequently and headings for which the indexing frequency is very low. We find that when we combine the MTI suggestions and the prediction of the learning algorithms, the performance improves compared to any single method for most of the evaluated MeSH headings. PMID:24551371

Comparison and combination of several MeSH indexing approaches.

PubMed

Yepes, Antonio Jose Jimeno; Mork, James G; Demner-Fushman, Dina; Aronson, Alan R

2013-01-01

MeSH indexing of MEDLINE is becoming a more difficult task for the group of highly qualified indexing staff at the US National Library of Medicine, due to the large yearly growth of MEDLINE and the increasing size of MeSH. Since 2002, this task has been assisted by the Medical Text Indexer or MTI program. We extend previous machine learning analysis by adding a more diverse set of MeSH headings targeting examples where MTI has been shown to perform poorly. Machine learning algorithms exceed MTI's performance on MeSH headings that are used very frequently and headings for which the indexing frequency is very low. We find that when we combine the MTI suggestions and the prediction of the learning algorithms, the performance improves compared to any single method for most of the evaluated MeSH headings.

Prep-ME Software Implementation and Enhancement : technical summary

DOT National Transportation Integrated Search

2017-09-01

Pavement ME Design (previously MEPDG/DARWin-ME) is a significant advancement in pavement design, though requiring more inputs from various sources. Through efforts by the Louisiana Transportation Research Center (LTRC) and Federal Highway Administrat...

Implementation of Enhanced Attenuation at the DOE Mound Site OU-1 Landfill: Accelerating Progress and Reducing Costs

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hooten, Gwendolyn; Cato, Rebecca; Looney, Brian

At the US Department of Energy (DOE), Office of Legacy Management, Mound, Ohio, Site, chlorinated organic contaminants (cVOCs) originating from the former solid-waste landfill have impacted groundwater in Operable Unit 1 (OU-1). The baseline groundwater remedy was groundwater pump and treat (P&T). Since the source materials have been removed from the landfill, the Mound core team, which consists of DOE, US Environmental Protection Agency (US EPA), Ohio EPA, and other stakeholders, is assessing the feasibility of switching from the active P&T remedy to a passive attenuation-based remedy. Toward this end, an enhanced attenuation (EA) strategy based on the creation ofmore » structured geochemical zones was developed. This EA strategy addresses the residual areas of elevated cVOCs in soil and groundwater while minimizing the rebound of groundwater concentrations above regulatory targets (e.g., maximum contaminant levels [MCLs]) and avoiding plume expansion while the P&T system is turned off. The EA strategy has improved confidence and reduced risk on the OU-1 groundwater transition path to monitored natural attenuation (MNA). To better evaluate the EA strategy, DOE is conducting a field demonstration to evaluate the use of edible oils to enhance the natural attenuation processes. The field demonstration is designed to determine whether structured geochemical zones can be established that expedite the attenuation of cVOCs in the OU-1 groundwater. The EA approach at OU-1 was designed based on “structured geochemical zones” and relies on groundwater flow through a succession of anaerobic and aerobic zones. The anaerobic zones stimulate relatively rapid degradation of the original solvent source compounds (e.g., cVOCs such as tetrachloroethene [PCE] and trichloroethene [TCE]). The surrounding aerobic areas encourage relatively rapid degradation of daughter products (such as dichloroethene [DCE] and vinyl chloride [VC]) as well as enhanced cometabolism of TCE

A qualitative natural history study of ME/CFS in the community.

PubMed

Anderson, Valerie R; Jason, Leonard A; Hlavaty, Laura E

2014-01-01

In previous qualitative research on Myalgic Encephalomyelitis/chronic fatigue syndrome (ME/CFS), researchers have focused on the experiences of patients with ME/CFS in tertiary care samples. This qualitative study examined the natural history of people with ME/CFS (n = 19) from a community-based sample. Findings highlighted multilayered themes involving the illness experience and the physical construction of ME/CFS. In addition, this study further illuminated unique subthemes regarding community response and treatment, which have implications for understanding the progression of ME/CFS as well as experiences of those within patient networks. There is a need for more longitudinal qualitative research on epidemiological samples of patients with ME/CFS.

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis.

PubMed

Lacerda, Eliana M; Bowman, Erinna W; Cliff, Jacqueline M; Kingdon, Caroline C; King, Elizabeth C; Lee, Ji-Sook; Clark, Taane G; Dockrell, Hazel M; Riley, Eleanor M; Curran, Hayley; Nacul, Luis

2017-01-01

The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18-60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots). Extensive dataset (700 clinical and socio-demographic variables/participant) enables comprehensive phenotyping. Potential reuse is conditional to ethical approval.

FIELD SCALE EVALUATION OF TREATMENT OF TCE IN A BIOWALL AT THE OU-1 SITE

EPA Science Inventory

A passive reactive barrier (Biowall) was installed at the OU-1 site at Altus Air Force Base, Oklahoma to treat TCE contamination in ground water from a landfill. Depth to ground water varies from 1.8 to 2.4 meters below land surface. To intercept and treat the plume of contamin...

Cis-existence of H3K27me3 and H3K36me2 in mouse embryonic stem cells revealed by specific ions of isobaric modification chromatogram.

PubMed

Mao, Hailei; Han, Gang; Xu, Longyong; Zhu, Duming; Lin, Hanqing; Cao, Xiongwen; Yu, Yi; Chen, Charlie Degui

2015-07-21

Histone H3 lysine 27 trimethylation (H3K27me3) and H3 lysine 36 trimethylation (H3K36me3) are important epigenetic modifications correlated with transcription repression and activation, respectively. These two opposing modifications rarely co-exist in the same H3 polypeptide. However, a small but significant amount of H3 tails are modified with 5 methyl groups on K27 and K36 in mouse embryonic stem cells (mESCs) and it is unclear how the trimethylation is distributed on K27 or K36. A label-free, bottom-up mass spectrum method, named specific ions of isobaric modification chromatogram (SIMC), was established to quantify the relative abundance of K27me2-K36me3 and K27me3-K36me2 in the same histone H3 tail. By using this method, we demonstrated that the H3K27me3-K36me2 comprises about 85 % of the penta-methylated H3 tails at K27 and K36 in mESCs. Upon mESC differentiation, the abundance of H3K27me3-K36me2 significantly decreased, while the level of H3K27me2-K36me3 remains unchanged. Our study not only revealed the cis-existence of H3K27me3-K36me2 in mESCs, but also suggested that this combinatorial histone modification may assume a specific regulatory function during differentiation.

High-pressure systematic of NaMe3+Si2O6 pyroxenes: volume compression vs Me3+ cation radius

NASA Astrophysics Data System (ADS)

Periotto, Benedetta; Nestola, Fabrizio; Balic-Zunic, Tonci; Pasqual, Daria; Alvaro, Matteo; Ohashi, Haruo

2010-05-01

Recent investigations have been experimentally demonstrated that Na-clinopyroxenes (Na-cpx) can be stable throughout a wide range of temperatures and pressures in the upper mantle and several works have been carried out in order to better constrain their physical properties. In this work the equation of state of a synthetic NaInSi2O6 clinopyroxene characterized by a trivalent non 3d-transition metal at the Me3+ crystallographic site (space group C2/c) was determined up to about 8 GPa by in situ single-crystal X-ray diffraction. Since previous investigations on CaMe2+Si2O6 showed a different effect when 3d- and non 3d-transition elements located at Me site, the aim of this study is to provide a definitive model capable to predict the high-pressure behaviour of (Ca,Na)(Me2+, Me3+)Si2O6 clinopyroxenes. A single crystal of NaInSi2O6 with size 150*80*50 microns3 was selected for the high-pressure single-crystal X-ray diffraction study. The sample was loaded in an ETH-type diamond anvil cell assembled with a diamond culet of 600 microns in diameter and a gasket preindented to 90 microns with a spark eroded hole of 200 microns in diameter. The cpx was loaded together with a single-crystal of quartz used as an internal pressure standard and some ruby chips used for more approximate determination of the internal pressure. The measurements were performed using a four-circles STOE STADI IV diffractometer on which the software SINGLE08 has been recently installed allowing to perform the eight-position diffracted-beam centering and to fit the diffraction peak profiles. Such centering procedure allows to obtain precise and accurate unit-cell parameters in order to provide values of room pressure bulk modulus affected by a significantly small error. The NaInSi2O6 cpx was investigated at 12 different pressures up to 7.83 GPa. No evidences of phase transformation were found throughout the pressure range investigated. The sample compresses anisotropically with the b direction being

Study on viscosity of MDEA-MeOH aqueous solutions

NASA Astrophysics Data System (ADS)

Wang, F.; Wang, L. M.; Wang, S. Q.; Fu, D.

2017-03-01

The viscosities of the N-methyldiethanolamine (MDEA)-methanol (MeOH) aqueous solutions were measured at temperatures ranging from (303.2 to 323.2) K. The mass fraction of MDEA and MeOH respectively ranged from 0.2 to 0.4 and 0 to 0.15. On the basis of experimental measurement, the effects of temperature, mass fraction of MDEA and MeOH on viscosities were demonstrated.

Guidelines for PCC inputs to AASHTOWare Pavement ME.

DOT National Transportation Integrated Search

2014-12-01

The objective of this research study was to develop guidelines for portland cement concrete (PCC) material inputs to the : AASHTOWare Pavement ME Design program. The AASHTOWare Pavement ME Design is the software program used by the : Mississippi Depa...

Effect of 30 MeV Li3+ ion and 8 MeV electron irradiation on N-channel MOSFETs

NASA Astrophysics Data System (ADS)

Prakash, A. P. G.; Ganesh, K. C. P.; Nagesha, Y. N.; Umakanth, D.; Arora, S. K.; Siddappa, K.

The effect of 30 MeV Li3+ ion and 8 MeV electron irradiation on the threshold voltage (V-TH), the voltage shift due to interface trapped charge (DeltaV(Nit)), the voltage shift due to oxide trapped charge (DeltaV(Not)), the density of interface trapped charge (DeltaN(it)), the density of oxide trapped charge (DeltaN(ot) ) and the drain saturation current (I-D Sat) were studied as a function of fluence. Considerable increase in DeltaN(it) and DeltaN(ot) , and decrease in V-TH and I-D Sat were observed in both types of irradiation. The observed difference in the properties of Li3+ ion and electron irradiated MOSFETs are interpreted on the basis of energy loss process associated with the type of radiation. The study showed that the 30 MeV Li3+ ion irradiation produce more damage when compared to the 8 MeV electron irradiation because of the higher electronic energy loss value. High temperature annealing studies showed that trapped charge generated during ion and electron irradiation was annealed out at 500 degreesC.

Synthesis of Organotitanium(IV) Fluoride Phosphates and the Crystal Structure of [(C5Me4Et)TiF(µ-F){µ-O2P(OSiMe3)2}]2.

PubMed

Pevec, Andrej; Demšar, Alojz; Pinkas, Jiri; Necas, Marek

2012-03-01

The complexes [(C5Me4R)TiF(µ-F)µ-O2P(OSiMe3)2]2 [R = Me (1), Et (2)] were prepared from [(C5Me4R)TiF3]2, (R = Me, Et) and OP(OSiMe3)3. The molecular structure of 2 has been determined by single-crystal X-ray diffraction analysis. An eight-membered Ti2O4P2 metallacycle bridged by two fluorine ligands between two titanium centers is observed.

76 FR 36285 - Establishment of Class E Airspace; Brunswick, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2011-06-22

...-0116; Airspace Docket No. 11-ANE-1] Establishment of Class E Airspace; Brunswick, ME AGENCY: Federal... at Brunswick, ME, to accommodate the additional airspace needed for the Standard Instrument Approach... Executive Airport, Brunswick, ME (75 FR 14824) Docket No. FAA-2011-0116. Interested parties were invited to...

Steric and electronic effects on arylthiolate coordination in the pseudotetrahedral complexes [(Tp(Ph,Me))Ni-SAr] (Tp(Ph,Me) = hydrotris{3-phenyl-5-methyl-1-pyrazolyl}borate).

PubMed

Deb, Tapash; Anderson, Caitlin M; Chattopadhyay, Swarup; Ma, Huaibo; Young, Victor G; Jensen, Michael P

2014-12-14

Synthesis and characterization of several new pseudotetrahedral arylthiolate complexes [(Tp(Ph,Me))Ni-SAr] (Tp(Ph,Me) = hydrotris{3-phenyl-5-methyl-1-pyrazolyl}borate; Ar = Ph, 2,4,6-(i)Pr3C6H2, C6H4-4-Cl, C6H4-4-Me, C6H4-4-OMe) are reported, including X-ray crystal structures of the first two complexes. With prior results, two series of complexes are spanned, [(Tp(Ph,Me))Ni-S-2,4,6-RC6H2] (R'' = H, Me, (i)Pr) plus the xylyl analogue [(Tp(Ph,Me))Ni-S-2,6-Me2C6H3], as well as [(Tp(Ph,Me))Ni-S-C6H4-4-Y] (Y = Cl, H, Me, OMe), intended to elucidate steric and/or electronic effects on arylthiolate coordination. In contrast to [(Tp(Me,Me))Ni-SAr] analogues that adopt a sawhorse conformation, the ortho-disubstituted complexes show enhanced trigonal and Ni-S-Ar bending, reflecting the size of the 3-pyrazole substituents. Moreover, weakened scorpionate ligation is implied by spectroscopic data. Little spectroscopic effect is observed in the series of para-substituted complexes, suggesting the observed effects are primarily steric in origin. The relatively electron-rich and encumbered complex [(Tp(Ph,Me))Ni-S-2,4,6-(i)Pr3C6H2] behaves uniquely when dissolved in CH3CN, forming a square planar solvent adduct with a bidentate scorpionate ligand, [(κ(2)-Tp(Ph,Me))Ni(NCMe)(S-2,4,6-(i)Pr3C6H2)]. This adduct was isolated and characterized by X-ray crystallography. Single-point DFT and TD-DFT calculations on a simplified [(κ(2)-Tp)Ni(NCMe)(SPh)] model were used to clarify the electronic spectrum of the adduct, and to elucidate differences between Ni-SAr bonding and spectroscopy between pseudotetrahedral and square planar geometries.

H3K27me3 and H3K4me3 chromatin environment at super-induced dehydration stress memory genes of Arabidopsis thaliana.

PubMed

Liu, Ning; Fromm, Michael; Avramova, Zoya

2014-03-01

Pre-exposure to a stress may alter the plant's cellular, biochemical, and/or transcriptional responses during future encounters as a 'memory' from the previous stress. Genes increasing transcription in response to a first dehydration stress, but producing much higher transcript levels in a subsequent stress, represent the super-induced 'transcription memory' genes in Arabidopsis thaliana. The chromatin environment (histone H3 tri-methylations of Lys 4 and Lys 27, H3K4me3, and H3K27me3) studied at five dehydration stress memory genes revealed existence of distinct memory-response subclasses that responded differently to CLF deficiency and displayed different transcriptional activities during the watered recovery periods. Among the most important findings is the novel aspect of the H3K27me3 function observed at specific dehydration stress memory genes. In contrast to its well-known role as a chromatin repressive mechanism at developmentally regulated genes, H3K27me3 did not prevent transcription from the dehydration stress-responding genes. The high H3K27me3 levels present during transcriptionally inactive states did not interfere with the transition to active transcription and with H3K4me3 accumulation. H3K4me3 and H3K27me3 marks function independently and are not mutually exclusive at the dehydration stress-responding memory genes.

The UK ME/CFS Biobank for biomedical research on Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) and Multiple Sclerosis

PubMed Central

Lacerda, Eliana M.; Bowman, Erinna W.; Cliff, Jacqueline M.; Kingdon, Caroline C.; King, Elizabeth C.; Lee, Ji-Sook; Clark, Taane G.; Dockrell, Hazel M.; Riley, Eleanor M.; Curran, Hayley; Nacul, Luis

2017-01-01

The UK ME/CFS Biobank was launched in August 2011 following extensive consultation with professionals and patient representatives. The bioresource aims to enhance research on myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), related to pathophysiology, biomarkers and therapeutic approaches. The cohort includes 18–60 year olds, encompassing 284 clinically-confirmed ME/CFS cases, 60 neurologist-diagnosed multiple sclerosis (MS) cases, and 135 healthy individuals. The Biobank contains blood samples, aliquoted into serum, plasma, peripheral blood mononuclear cells (PBMC), red blood cells/granulocyte pellet, whole blood, and RNA (totalling 29,863 aliquots). Extensive dataset (700 clinical and socio-demographic variables/participant) enables comprehensive phenotyping. Potential reuse is conditional to ethical approval. PMID:28649428

78 FR 6727 - Amendment of Class E Airspace; Lincoln, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2013-01-31

...-0764; Airspace Docket No. 12-ANE-12] Amendment of Class E Airspace; Lincoln, ME AGENCY: Federal... Lincoln, ME, as the Lincoln Non-Directional Beacon (NDB) has been decommissioned and new Standard... in the Federal Register a notice of proposed rulemaking to amend Class E airspace at Lincoln, ME (77...

76 FR 39259 - Establishment of Class E Airspace; Brunswick, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2011-07-06

...-0116; Airspace Docket No. 11-ANE-1] Establishment of Class E Airspace; Brunswick, ME AGENCY: Federal... Class E airspace at Brunswick Executive Airport, Brunswick, ME. DATES: The effective date is moved from... Class E airspace at Brunswick Executive Airport, Brunswick, ME. This action will move up the effective...

The Proposed 2 MeV Electron Cooler for COSY

DOE Office of Scientific and Technical Information (OSTI.GOV)

Dietrich, Juergen; Parkhomchuk, Vasily V.; Reva, Vladimir B.

2006-03-20

The design, construction and installation of a 2 MeV electron cooling system for COSY is proposed to further boost the luminosity even with strong heating effects of high-density internal targets. In addition the design of the 2 MeV electron cooler for COSY is intended to test some new features of the high energy electron cooler for HESR at GSI. The design of the 2 MeV electron cooler will be accomplished in cooperation with the Budker Institute of Nuclear Physics in Novosibirsk, Russia. Starting with the boundary conditions of the existing electron cooler at COSY the requirements and a first generalmore » scheme of the 2 MeV electron cooler are described.« less

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages.

PubMed

Ball, Michael S; Shipman, Emilie P; Kim, Hyunjung; Liby, Karen T; Pioli, Patricia A

2016-01-01

Tumor-associated macrophages can account for up to 50% of the tumor mass in breast cancer patients and high TAM density is associated with poor clinical prognosis. Because TAMs enhance tumor growth, development, and metastatic potential, redirection of TAM activation may have significant therapeutic benefit. Our studies in primary human macrophages and murine breast TAMs suggest that the synthetic oleanane triterpenoid CDDO-methyl ester (CDDO-Me) reprograms the activation profile of TAMs from tumor-promoting to tumor-inhibiting. We show that CDDO-Me treatment inhibits expression of IL-10 and VEGF in stimulated human M2 macrophages and TAMs but increases expression of TNF-α and IL-6. Surface expression of CD206 and CD163, which are characteristic of M2 activation, is significantly attenuated by CDDO-Me. In contrast, CDDO-Me up-regulates surface expression of HLA-DR and CD80, which are markers of M1 activation, and importantly potentiates macrophage activation of autologous T cells but inhibits endothelial cell vascularization. These results show for the first time that CDDO-Me redirects activation of M2 macrophages and TAMs from immune-suppressive to immune-stimulatory, and implicate a role for CDDO-Me as an immunotherapeutic in the treatment of breast and potentially other types of cancer.

CDDO-Me Redirects Activation of Breast Tumor Associated Macrophages

PubMed Central

Ball, Michael S.; Shipman, Emilie P.; Kim, Hyunjung; Liby, Karen T.; Pioli, Patricia A.

2016-01-01

Tumor-associated macrophages can account for up to 50% of the tumor mass in breast cancer patients and high TAM density is associated with poor clinical prognosis. Because TAMs enhance tumor growth, development, and metastatic potential, redirection of TAM activation may have significant therapeutic benefit. Our studies in primary human macrophages and murine breast TAMs suggest that the synthetic oleanane triterpenoid CDDO-methyl ester (CDDO-Me) reprograms the activation profile of TAMs from tumor-promoting to tumor-inhibiting. We show that CDDO-Me treatment inhibits expression of IL-10 and VEGF in stimulated human M2 macrophages and TAMs but increases expression of TNF-α and IL-6. Surface expression of CD206 and CD163, which are characteristic of M2 activation, is significantly attenuated by CDDO-Me. In contrast, CDDO-Me up-regulates surface expression of HLA-DR and CD80, which are markers of M1 activation, and importantly potentiates macrophage activation of autologous T cells but inhibits endothelial cell vascularization. These results show for the first time that CDDO-Me redirects activation of M2 macrophages and TAMs from immune-suppressive to immune-stimulatory, and implicate a role for CDDO-Me as an immunotherapeutic in the treatment of breast and potentially other types of cancer. PMID:26918785

The calibration of photographic and spectroscopic films: The response of 2aO film to small dosages of alpha particles from 3/10th's rad to 8 rads at energy levels 153 MeV, 79 MeV and 47 MeV

NASA Technical Reports Server (NTRS)

Hammond, E. C., Jr.; Peters, Kevin; Stober, AL

1984-01-01

The 2aO film, pre-exposed to a series of neutral density filters which on development under standard conditions will produce the standard H-D curve for that film, were then exposed to Alpha paricles with a dose range of 3/10ths rads to 8 rads while varying the energy of the particles using 153 MeV, 70 MeV, and 47 MeV, respectively. An analysis of the film shows that the 3/10th rad dose produces the lowest optical density changes at 70 MeV and 47 MeV. While the optical density readings for the darker patterns seem to oscillate and decrease when exposed to radiation dosages of 3/10th rads to 8 rads.

Ferroelectric and structural instability in double perovskites Me1+Bi3+Me3+Nb5+O6 (Me1+ = Na, K, Rb; Me3+ = Sc, Ga, In, Lu)

NASA Astrophysics Data System (ADS)

Zinenko, V. I.; Zamkova, N. G.; Zhandun, V. S.; Pavlovskii, M. S.

2012-06-01

Within the Gordon-Kim generalized model with regard to the polarizabilities of ions, the lattice constants, the high-frequency permittivity, the Born dynamic charges, and the vibration constants of the crystal lattice are calculated for cation-ordered double perovskites Me1+Bi3+Me3+Nb5+O6. The vibration spectra of all the compounds exhibit two types of instabilities: instability associated with the rotation of the oxygen octahedron and ferroelectric instability. Various combinations of distortions with respect to the rotation mode yield five energetically most favorable distorted phases. The symmetry and the energy characteristics of these phases are discussed. In four of the five phases, the distortions associated with the oxygen octahedron rotation lead to polar phases, thus allowing one to speak of improper ferroelectricity in these compounds. One phase turns out to be nonpolar; however, it contains unstable polar modes such that a displacement along the eigenvectors of these modes gives rise to polarization in the crystal.

Association of H3K9me3 and H3K27me3 repressive histone marks with breast cancer subtypes in the Nurses' Health Study.

PubMed

Healey, Megan A; Hu, Rong; Beck, Andrew H; Collins, Laura C; Schnitt, Stuart J; Tamimi, Rulla M; Hazra, Aditi

2014-10-01

Repressive histone tail modifications have been associated with molecular breast cancer subtypes. We investigated whether histone 3 lysine 9 trimethylation (H3K9me3) and histone 3 lysine 27 trimethylation (H3K27me3) were associated with tumor features and subtypes while adjusting for prospectively collected reproductive and lifestyle breast cancer risk factors. We have tissue microarray data with immunohistochemical marker information on 804 incident cases of invasive breast cancer diagnosed from 1976-2000 in the Nurses' Health Study. Tissue microarray sections were stained for global H3K9me3 and H3K27me3, and scored into four categories. Multivariate odds ratios (OR) and 95 % confidence intervals (CI) were calculated using logistic regression models for tumor features and subtypes, adjusting for breast cancer risk factors. While there were no significant associations between H3K9me3 and tumor features, H3K27me3 was significantly associated with lower grade tumors compared to high grade tumors in the multivariate model (OR = 1.95, 95 % CI 1.35-2.81, p = 0.0004). H3K27me3 was suggestively associated with estrogen receptor-positive (ER+) tumors (OR = 1.47, 95 % CI 0.97-2.23, p = 0.07). In subtype analyses, H3K27me3 was positively associated with the luminal A subtype compared to all other subtypes (OR = 1.42, 95 % CI 1.14-1.77, p = 0.002), and was inversely associated with HER2-type (OR = 0.58, 95 % CI 0.37-0.91, p = 0.02) and basal-like breast cancer (OR = 0.52, 95 % CI 0.36-0.76, p = 0.0006). In the largest immunohistochemical examination of H3K9me3 and H3K27me3 in breast cancer, we found that H3K27me3 positivity, but not H3K9me3, was associated with lower grade tumors and the luminal A subtype after adjusting for reproductive and lifestyle breast cancer risk factors.

"Open mesh" or "strictly selected population" recruitment? The experience of the randomized controlled MeMeMe trial.

PubMed

Cortellini, Mauro; Berrino, Franco; Pasanisi, Patrizia

2017-01-01

Among randomized controlled trials (RCTs), trials for primary prevention require large samples and long follow-up to obtain a high-quality outcome; therefore the recruitment process and the drop-out rates largely dictate the adequacy of the results. We are conducting a Phase III trial on persons with metabolic syndrome to test the hypothesis that comprehensive lifestyle changes and/or metformin treatment prevents age-related chronic diseases (the MeMeMe trial, EudraCT number: 2012-005427-32, also registered on ClinicalTrials.gov [NCT02960711]). Here, we briefly analyze and discuss the reasons which may lead to participants dropping out from trials. In our experience, participants may back out of a trial for different reasons. Drug-induced side effects are certainly the most compelling reason. But what are the other reasons, relating to the participants' perception of the progress of the trial which led them to withdraw after randomization? What about the time-dependent drop-out rate in primary prevention trials? The primary outcome of this analysis is the point of drop-out from trial, defined as the time from the randomization date to the withdrawal date. Survival functions were non-parametrically estimated using the product-limit estimator. The curves were statistically compared using the log-rank test ( P =0.64, not significant). Researchers involved in primary prevention RCTs seem to have to deal with the paradox of the proverbial "short blanket syndrome". Recruiting only highly motivated candidates might be useful for the smooth progress of the trial but it may lead to a very low enrollment rate. On the other hand, what about enrolling all the eligible subjects without considering their motivation? This might boost the enrollment rate, but it can lead to biased results on account of large proportions of drop-outs. Our experience suggests that participants do not change their mind depending on the allocation group (intervention or control). There is no single

40 CFR 1068.1 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Does this part apply to me? 1068.1... § 1068.1 Does this part apply to me? (a) The provisions of this part apply to everyone with respect to... to me? (a) * * * (3) Stationary compression-ignition engines certified using the provisions of 40 CFR...

40 CFR 1068.1 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Does this part apply to me? 1068.1... Miscellaneous Provisions § 1068.1 Does this part apply to me? (a) The provisions of this part apply to everyone... this part apply to me? (b) This part does not apply to any of the following engine or vehicle...

Les agressions sexuelles des jeunes ayant une incapacité ou une maladie chronique

PubMed Central

Kaufman, M

2011-01-01

Pour diverses raisons, les enfants et les adolescents ayant une incapacité ou une maladie chronique sont plus vulnérables aux agressions sexuelles. Les dispensateurs de soins, de même que les parents et les éducateurs, doivent se méfier davantage de la possibilité d’agression sexuelle au sein de cette population. Les médecins, tout particulièrement, doivent prôner des politiques pour prévenir ou déceler les agressions dans les hôpitaux, les écoles et autres établissements. Ces politiques incluent le dépistage détaillé et la surveillance étroite des employés et des bénévoles, la présence d’un chaperon aux examens physiques et aux interventions thérapeutiques, la supervision des sorties et une culture qui favorise la vie privée du patient en établissement. De plus, les médecins doivent favoriser la conscience de soi et l’habilitation des patients et leur donner très tôt des conseils préventifs au sujet de la sexualité, de l’habilitation personnelle et des risques d’agression. Le présent document de principes remplace celui que la Société canadienne de pédiatrie a publié en 1997.

Traffic and data preparation for AASHTO DARWin-ME analysis and design.

DOT National Transportation Integrated Search

2015-02-01

Pavement ME Design (MEPDG/DARWin-ME) is a significant advancement in pavement design, but : requires much more inputs from various sources. Through the transportation pooled fund study TPF- : 5(242), a full-production software Prep-ME with comprehens...

The MeSH translation maintenance system: structure, interface design, and implementation.

PubMed

Nelson, Stuart J; Schopen, Michael; Savage, Allan G; Schulman, Jacque-Lynne; Arluk, Natalie

2004-01-01

The National Library of Medicine (NLM) produces annual editions of the Medical Subject Headings (MeSH). Translations of MeSH are often done to make the vocabulary useful for non-English users. However, MeSH translators have encountered difficulties with entry vocabulary as they maintain and update their translation. Tracking MeSH changes and updating their translations in a reasonable time frame is cumbersome. NLM has developed and implemented a concept-centered vocabulary maintenance system for MeSH. This system has been extended to create an interlingual database of translations, the MeSH Translation Maintenance System (MTMS). This database allows continual updating of the translations, as well as facilitating tracking of the changes within MeSH from one year to another. The MTMS interface uses a Web-based design with multiple colors and fonts to indicate concepts needing translation or review. Concepts for which there is no exact English equivalent can be added. The system software encourages compliance with the Unicode standard in order to ensure that character sets with native alphabets and full orthography are used consistently.

Cooperation or Competition? The American and French Foreign Policies in Africa (Cooperation ou concurrence? La politique africaine de la France et des Etats-Unis en Afrique sub-saharienne)

DTIC Science & Technology

2005-07-26

Villepin, appelle « des conflits ancestraux >>, c’est-di-dire des conflits pour le contr6le de ressources primaires , ou de territoire, ou pour des diff~rends...traduira par une plus grande attention portde aux sujets africains et aussi d la part du budget pour l’Afrique. Le facteur religieux Les missionnaires en...grands avions de transport ou celles des soldats 6tablissant des centres de soins m6dicaux avec les ONG. Comme Jean-Paul Ngoupand6 l’a exprim6: << On

40 CFR 1068.1 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Does this part apply to me? 1068.1... Miscellaneous Provisions § 1068.1 Does this part apply to me? (a) The provisions of this part apply to everyone... follows: § 1068.1 Does this part apply to me? (b) This part does not apply to any of the following engine...

Assigning categorical information to Japanese medical terms using MeSH and MEDLINE.

PubMed

Onogi, Yuzo

2007-01-01

This paper reports on the assigning of MeSH (Medical Subject Headings) categories to Japanese terms in an English-Japanese dictionary using the titles and abstracts of articles indexed in MEDLINE. In a previous study, 30,000 of 80,000 terms in the dictionary were mapped to MeSH terms by normalized comparison. It was reasoned that if the remaining dictionary terms appeared in MEDLINE-indexed articles that are indexed using MeSH terms, then relevancies between the dictionary terms and MeSH terms could be calculated, and thus MeSH categories assigned. This study compares two approaches for calculating the weight matrix. One is the TF*IDF method and the other uses the inner product of two weight matrices. About 20,000 additional dictionary terms were identified in MEDLINE-indexed articles published between 2000 and 2004. The precision and recall of these algorithms were evaluated separately for MeSH terms and non-MeSH terms. Unfortunately, the precision and recall of the algorithms was not good, but this method will help with manual assignment of MeSH categories to dictionary terms.

Geology and hydrocarbon potential of the Oued Mya basin, Algeria

DOE Office of Scientific and Technical Information (OSTI.GOV)

Benamrane, O.; Messaoudi, M.; Messelles, H.

1993-09-01

The Oued Mya hydrocarbon system is located in the Sahara basin. It is one of the best producing basins in Algeria, along with the Ghadames and Illizi basins. The stratigraphic section consists of Paleozoic and Mesozoic, and is about 5000 m thick. This intracratonic basin is limited to the north by the Toughourt saddle, and to the west and east it is flanked by regional arches, Allal-Tilghemt and Amguid-Hassi Messaoud, which culminate in the super giant Hassi Messaoud and Hassi R'mel hydrocarbon accumulations, respectively, producing oil from the Cambrian sands and gas from the Trissic sands. The primary source rockmore » in this basin is lower Silurian shale, with an average thickness of 50 m and a total organic carbon of 6% (14% in some cases). Results of maturation modeling indicate that the lower Silurian source is in the oil window. The Ordovician shales are also source rocks, but in a second order. Clastic reservoirs are in the Trissic sequence, which is mainly fluvial deposits with complex alluvial channels, and the main target in the basin. Clastic reservoirs in the lower Devonian section have a good hydrocarbon potential east of the basin through a southwest-northwest orientation. The Late Trissic-Early Jurassic evaporites that overlie the Triassic clastic interval and extend over the entire Oued Mya basin, are considered to be a super-seal evaporite package, which consists predominantly of anhydrite and halite. For paleozoic targets, a large number of potential seals exist within the stratigraphic column. This super seal does not present oil dismigration possibilities. We can infer that a large amount of the oil generated by the Silurian source rock from the beginning of Cretaceous until now still is not discovered and significantly greater volumes could be trapped within structure closures and mixed or stratigraphic traps related to the fluvial Triassic sandstones, marine Devonian sands, and Cambrian-Ordovician reservoirs.« less

76 FR 14824 - Proposed Establishment of Class E Airspace; Brunswick, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2011-03-18

...-0116; Airspace Docket No. 11-ANE-1] Proposed Establishment of Class E Airspace; Brunswick, ME AGENCY... action proposes to establish Class E Airspace at Brunswick, ME, to accommodate new Standard Instrument... Brunswick, ME to provide airspace required to support the standard instrument approach procedures developed...

Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor

PubMed Central

Halberstadt, Adam L.; Nichols, David E.; Geyer, Mark A.

2012-01-01

RATIONALE Ayahuasca is a psychoactive tea prepared from a combination of plants that contain a hallucinogenic tryptamine and monoamine oxidase inhibitors (MAOIs). Behavioral Pattern Monitor (BPM) experiments demonstrated that the combination of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and a behaviorally inactive dose of an MAOA inhibitor such as harmaline or clorgyline induces biphasic effects on locomotor activity in rats, initially reducing locomotion and then increasing activity as time progresses. OBJECTIVES The present study investigated whether the biphasic locomotor profile induced by the combination of 5-MeO-DMT and an MAOI is a consequence of a reduction in the rate of 5-MeO-DMT metabolism. This hypothesis was tested using a deuterated derivative of 5-MeO-DMT (α,α,β,β-tetradeutero-5-MeO-DMT) that is resistant to metabolism by MAO. RESULTS Confirming our previous findings, 1.0 mg/kg 5-MeO-DMT (s.c.) had biphasic effects on locomotor activity in rats pretreated with a behaviorally inactive dose of the nonselective MAOI pargyline (10 mg/kg). Administration of 5-MeO-DMT alone, even at doses greater than 1.0 mg/kg, produced only reductions in locomotor activity. Although low doses of α,α,β,β-tetradeutero-5-MeO-DMT (0.3 and 1.0 mg/kg, s.c.) produced only hypoactivity in the BPM, a dose of 3.0 mg/kg induced a biphasic locomotor profile similar to that produced by the combination of 5-MeO-DMT and an MAOI. Receptor binding studies demonstrated that deuterium substitution had little effect on the affinity of 5-MeO-DMT for a wide variety of neurotransmitter binding sites. CONCLUSIONS The finding with α,α,β,β-tetradeutero-5-MeO-DMT indicates that the hyperactivity induced by 5-MeO-DMT after MAO inhibition is a consequence of reduced metabolism of 5-MeO-DMT, leading to prolonged occupation of central serotonin receptors. These results demonstrate that deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects of

Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor.

PubMed

Halberstadt, Adam L; Nichols, David E; Geyer, Mark A

2012-06-01

Ayahuasca is a psychoactive tea prepared from a combination of plants that contain a hallucinogenic tryptamine and monoamine oxidase inhibitors (MAOIs). Behavioral pattern monitor (BPM) experiments demonstrated that the combination of 5-methoxy-N,N-dimethyltryptamine (5-MeO-DMT) and a behaviorally inactive dose of an MAO(A) inhibitor such as harmaline or clorgyline induces biphasic effects on locomotor activity in rats, initially reducing locomotion and then increasing activity as time progresses. The present study investigated whether the biphasic locomotor profile induced by the combination of 5-MeO-DMT and an MAOI is a consequence of a reduction in the rate of 5-MeO-DMT metabolism. This hypothesis was tested using a deuterated derivative of 5-MeO-DMT (α,α,β,β-tetradeutero-5-MeO-DMT) that is resistant to metabolism by MAO. Confirming our previous findings, 1.0 mg/kg 5-MeO-DMT (s.c.) had biphasic effects on locomotor activity in rats pretreated with a behaviorally inactive dose of the nonselective MAOI pargyline (10 mg/kg). Administration of 5-MeO-DMT alone, even at doses greater than 1.0 mg/kg, produced only reductions in locomotor activity. Although low doses of α,α,β,β-tetradeutero-5-MeO-DMT (0.3 and 1.0 mg/kg, s.c.) produced only hypoactivity in the BPM, a dose of 3.0 mg/kg induced a biphasic locomotor profile similar to that produced by the combination of 5-MeO-DMT and an MAOI. Receptor binding studies demonstrated that deuterium substitution had little effect on the affinity of 5-MeO-DMT for a wide variety of neurotransmitter binding sites. The finding with α,α,β,β-tetradeutero-5-MeO-DMT indicates that the hyperactivity induced by 5-MeO-DMT after MAO inhibition is a consequence of reduced metabolism of 5-MeO-DMT, leading to prolonged occupation of central serotonin receptors. These results demonstrate that deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects of tryptamine/MAOI combinations.

Brevipalpus phoenicis (Geijskes) sensu lato (Acari:Tenuipalpidae) no Brasil

USDA-ARS?s Scientific Manuscript database

Os ácaros tenuipalpídeos ou ácaros planos são importantes fitófagos constituintes do agroecossistema e florestas semitropical e tropical (JEPPSON et al., 1975; HOY, 2011), sendo que algumas espécies estão associadas à transmissão de fitovírus (CHAGAS et al., 2001 e 2003; CHILDERS et al., 2001; KITAJ...

Concept of a small satellite for sub-MeV and MeV all sky survey: the CAST mission

NASA Astrophysics Data System (ADS)

Nakazawa, Kazuhiro; Takahashi, Tadayuki; Ichinohe, Yuto; Takeda, Shin'ichiro; Tajima, Hiroyasu; Kamae, Tuneyoshi; Kokubun, Motohide; Takashima, Takeshi; Tashiro, Makoto; Tamagawa, Toru; Terada, Yukikatsu; Nomachi, Masaharu; Fukazawa, Yasushi; Makishima, Kazuo; Mizuno, Tsunefumi; Mitani, Takefumi; Yoshimitsu, Tetsuo; Watanabe, Shin

2012-09-01

MeV and sub-MeV energy band from ~200 keV to ~2 MeV contains rich information of high-energy phenomena in the universe. The CAST (Compton Telescope for Astro and Solar Terrestrial) mission is planned to be launched at the end of 2010s, and aims at providing all-sky map in this energy-band for the first time. It is made of a semiconductor Compton telescope utilizing Si as a scatterer and CdTe as an absorber. CAST provides allsky sub-MeV polarization map for the first time, as well. The Compton telescope technology is based on the design used in the Soft Gamma-ray Detector (SGD) onboard ASTRO-H, characterized by its tightly stacked semiconductor layers to obtain high Compton reconstruction efficiency. The CAST mission is currently planned as a candidate for the small scientific satellite series in ISAS/JAXA, weighting about 500 kg in total. Scalable detector design enables us to consider other options as well. Scientific outcome of CAST is wide. It will provide new information from high-energy sources, such as AGN and/or its jets, supernova remnants, magnetors, blackhole and neutron-star binaries and others. Polarization map will tell us about activities of jets and reflections in these sources, as well. In addition, CAST will simultaneously observe the Sun, and depending on its attitude, the Earth.

Explicación de las disparidades raciales en la salud neonatal en Brasil*

PubMed Central

Nyarko, Kwame A.; López-Camelo, Jorge; Castilla, Eduardo E.; Wehby, George L.

2015-01-01

Objetivos. Buscamos cuantificar la manera en que los efectos socioeconómicos, demográficos, geográficos y de atención de salud explican las disparidades raciales en las tasas de bajo peso al nacer y prematuridad en Brasil. Métodos. Utilizamos una muestra de 8 949 niños nacidos entre 1995 y el 2009 en 15 ciudades y 7 provincias de Brasil. Nos centramos en las disparidades en la prevalencia de bajo peso al nacer (< 2 500 g) y prematuridad (< 37 semanas de gestación) en recién nacidos de ascendencia solo africana o mezclada con otras ascendencias y de ascendencia solo europea. Usamos un modelo de descomposición para cuantificar la contribución de los factores conceptualmente pertinentes a esas disparidades. Resultados. El modelo permitió explicar entre 45% y 94% de las disparidades en cuanto al bajo peso al nacer y entre 64% y 94% de las disparidades en cuanto a la prematuridad entre los grupos de ascendencia africana y de ascendencia europea. Las diferencias en el uso de atención prenatal y en la ubicación geográfica fueron los factores más importantes, seguidos por las diferencias socioeconómicas. El modelo permitió explicar la mayoría de las disparidades en los recién nacidos de ascendencia africana mezclada y parte de las disparidades en los de ascendencia solo africana. Conclusiones. En las políticas públicas para mejorar la salud infantil se deben abordar las diferencias en cuanto a la atención prenatal y la ubicación geográfica a fin de reducir las disparidades en materia de salud entre los recién nacidos de ascendencia africana y los de ascendencia europea en Brasil.

COMPTEL neutron response at 17 MeV

NASA Technical Reports Server (NTRS)

Oneill, Terrence J.; Ait-Ouamer, Farid; Morris, Joann; Tumer, O. Tumay; White, R. Stephen; Zych, Allen D.

1992-01-01

The Compton imaging telescope (COMPTEL) instrument of the Gamma Ray Observatory was exposed to 17 MeV d,t neutrons prior to launch. These data were analyzed and compared with Monte Carlo calculations using the MCNP(LANL) code. Energy and angular resolutions are compared and absolute efficiencies are calculated at 0 and 30 degrees incident angle. The COMPTEL neutron responses at 17 MeV and higher energies are needed to understand solar flare neutron data.

77 FR 45985 - Proposed Amendment of Class E Airspace; Lincoln, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2012-08-02

...-0764; Airspace Docket No. 12-ANE-12] Proposed Amendment of Class E Airspace; Lincoln, ME AGENCY... action proposes to amend Class E Airspace at Lincoln, ME, as the Lincoln Non-Directional Radio Beacon..., Lincoln, ME. Airspace reconfiguration is necessary due to the decommissioning of the Lincoln NDB and...

Atomic layer deposition of high-density Pt nanodots on Al2O3 film using (MeCp)Pt(Me)3 and O2 precursors for nonvolatile memory applications

PubMed Central

2013-01-01

Pt nanodots have been grown on Al2O3 film via atomic layer deposition (ALD) using (MeCp)Pt(Me)3 and O2 precursors. Influence of the substrate temperature, pulse time of (MeCp)Pt(Me)3, and deposition cycles on ALD Pt has been studied comprehensively by scanning electron microscopy, transmission electron microscopy, and X-ray photoelectron spectroscopy. Therefore, Pt nanodots with a high density of approximately 2 × 1012 cm-2 have been achieved under optimized conditions: 300°C substrate temperature, 1 s pulse time of (MeCp)Pt(Me)3, and 70 deposition cycles. Further, metal-oxide-semiconductor capacitors with Pt nanodots embedded in ALD Al2O3 dielectric have been fabricated and characterized electrically, indicating noticeable electron trapping capacity, efficient programmable and erasable characteristics, and good charge retention. PMID:23413837

MeDICi Software Superglue for Data Analysis Pipelines

ScienceCinema

Ian Gorton

2017-12-09

The Middleware for Data-Intensive Computing (MeDICi) Integration Framework is an integrated middleware platform developed to solve data analysis and processing needs of scientists across many domains. MeDICi is scalable, easily modified, and robust to multiple languages, protocols, and hardware platforms, and in use today by PNNL scientists for bioinformatics, power grid failure analysis, and text analysis.

Total and differential cross sections of η-production in proton-deuteron fusion for excess energies between Qη = 13 MeV and Qη = 81 MeV

NASA Astrophysics Data System (ADS)

Adlarson, P.; Augustyniak, W.; Bardan, W.; Bashkanov, M.; Bergmann, F. S.; Berłowski, M.; Bondar, A.; Büscher, M.; Calén, H.; Ciepał, I.; Clement, H.; Czerwiński, E.; Demmich, K.; Engels, R.; Erven, A.; Erven, W.; Eyrich, W.; Fedorets, P.; Föhl, K.; Fransson, K.; Goldenbaum, F.; Goswami, A.; Grigoryev, K.; Gullström, C.-O.; Heijkenskjöld, L.; Hejny, V.; Hüsken, N.; Jarczyk, L.; Johansson, T.; Kamys, B.; Kemmerling, G.; Khatri, G.; Khoukaz, A.; Khreptak, A.; Kirillov, D. A.; Kistryn, S.; Kleines, H.; Kłos, B.; Krzemień, W.; Kulessa, P.; Kupść, A.; Kuzmin, A.; Lalwani, K.; Lersch, D.; Lorentz, B.; Magiera, A.; Maier, R.; Marciniewski, P.; Mariański, B.; Morsch, H.-P.; Moskal, P.; Ohm, H.; Parol, W.; Perez del Rio, E.; Piskunov, N. M.; Prasuhn, D.; Pszczel, D.; Pysz, K.; Pyszniak, A.; Ritman, J.; Roy, A.; Rudy, Z.; Rundel, O.; Sawant, S.; Schadmand, S.; Schätti-Ozerianska, I.; Sefzick, T.; Serdyuk, V.; Shwartz, B.; Sitterberg, K.; Skorodko, T.; Skurzok, M.; Smyrski, J.; Sopov, V.; Stassen, R.; Stepaniak, J.; Stephan, E.; Sterzenbach, G.; Stockhorst, H.; Ströher, H.; Szczurek, A.; Trzciński, A.; Wolke, M.; Wrońska, A.; Wüstner, P.; Yamamoto, A.; Zabierowski, J.; Zieliński, M. J.; Złomańczuk, J.; Żuprański, P.; Żurek, M.; Wilkin, C.; WASA-at-COSY Collaboration

2018-07-01

New data on both total and differential cross sections of the production of η mesons in proton-deuteron fusion to 3He η in the excess energy region 13.6MeV ≤Qη ≤ 80.9MeV are presented. These data have been obtained with the WASA-at-COSY detector setup located at the Forschungszentrum Jülich, using a proton beam at 15 different beam momenta between pp = 1.60GeV / c and pp = 1.74GeV / c. While significant structure of the total cross section is observed in the energy region 20MeV ≲Qη ≲ 60MeV, a previously reported sharp variation around Qη ≈ 50MeV cannot be confirmed. Angular distributions show the typical forward-peaking that was noted earlier. For the first time, it is possible to study the development of these angular distributions with rising excess energy over a wide interval.

Letter from Prashant Gupta, Honeywell to Galo Jackson, USEPA. Subject: Draft Feasibility Study Report for OU 1 (Estuary)

EPA Pesticide Factsheets

October 16, 2013 letter and attachment with responses to June 20, 2013 comments by USEPA about the Operable Unit 1 (OU1) at the LCP Chemicals site in Brunswick, Georgia. Region ID: 04 DocID: 10944892, DocDate: 10-16-2013

77 FR 45239 - Amendment of Class E Airspace; Bar Harbor, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2012-07-31

...-1366; Airspace Docket No. 11-ANE-13] Amendment of Class E Airspace; Bar Harbor, ME AGENCY: Federal... area at Bar Harbor, ME, as the Surry Non-Directional Radio Beacon (NDB) has been decommissioned and new... airspace at Bar Harbor, ME (77 FR 27666) Docket No. FAA-2011-1366. Interested parties were invited to...

The impact of CFS/ME on employment and productivity in the UK: a cross-sectional study based on the CFS/ME national outcomes database.

PubMed

Collin, Simon M; Crawley, Esther; May, Margaret T; Sterne, Jonathan A C; Hollingworth, William

2011-09-15

Few studies have investigated factors associated with discontinuation of employment in patients with CFS/ME or quantified its impact on productivity. We used patient-level data from five NHS CFS/ME services during the period 01/04/2006-31/03/2010 collated in the UK CFS/ME National Outcomes Database. We used logistic regression to identify factors associated with discontinuation of employment. We estimated UK-wide productivity costs using patient-level data on duration of illness before assessment by a CFS/ME service, duration of unemployment, age, sex and numbers of patients, in conjunction with Office for National Statistics income and population data. Data were available for 2,170 patients, of whom 1,669 (76.9%) were women. Current employment status was recorded for 1,991 patients (91.8%), of whom 811 patients (40.7%) were currently employed and 998 (50.1%) had discontinued their employment "because of fatigue-related symptoms". Older age, male sex, disability, fatigue, pain, and duration of illness were associated with cessation of employment. In a multivariable model, age, male sex, and disability remained as independent predictors. Total productivity costs among the 2,170 patients due to discontinuation of employment in the years preceding assessment by a specialist CFS/ME service (median duration of illness=36 months) were £49.2 million. Our sample was equivalent to 4,424 UK adults accessing specialist services each year, representing productivity costs to the UK economy of £102.2 million. Sensitivity analyses suggested a range between £75.5-£128.9 million. CFS/ME incurs huge productivity costs amongst the small fraction of adults with CFS/ME who access specialist services.

Prospects for indirect dark matter searches with MeV photons

DOE Office of Scientific and Technical Information (OSTI.GOV)

Bartels, Richard; Gaggero, Daniele; Weniger, Christoph, E-mail: r.t.bartels@uva.nl, E-mail: d.gaggero@uva.nl, E-mail: c.weniger@uva.nl

2017-05-01

Over the past decade, extensive studies have been undertaken to search for photon signals from dark matter annihilation or decay for dark matter particle masses above ∼1 GeV. However, due to the lacking sensitivity of current experiments at MeV–GeV energies, sometimes dubbed the 'MeV gap', dark matter models with MeV to sub-GeV particle masses have received little attention so far. Various proposed MeV missions (like, e.g., e-ASTROGAM or AMEGO) are aimed at closing this gap in the mid- or long-term future. This, and the absence of clear dark matter signals in the GeV–TeV range, makes it relevant to carefully reconsidermore » the expected experimental instrumental sensitivities in this mass range. The most common two-body annihilation channels for sub-GeV dark matter are to neutrinos, electrons, pions or directly to photons. Among these, only the electron channel has been extensively studied, and almost exclusively in the context of the 511 keV line. In this work, we study the prospects for detecting MeV dark matter annihilation in general in future MeV missions, using e-ASTROGAM as reference, and focusing on dark matter masses in the range 1 MeV–3 GeV. In the case of leptonic annihilation, we emphasise the importance of the often overlooked bremsstrahlung and in-flight annihilation spectral features, which in many cases provide the dominant gamma-ray signal in this regime.« less

WebMeV | Informatics Technology for Cancer Research (ITCR)

Cancer.gov

Web MeV (Multiple-experiment Viewer) is a web/cloud-based tool for genomic data analysis. Web MeV is being built to meet the challenge of exploring large public genomic data set with intuitive graphical interface providing access to state-of-the-art analytical tools.

EGRET observations of bursts at MeV energies

NASA Astrophysics Data System (ADS)

Catelli, J. R.; Dingus, B. L.; Schneid, E. J.

1998-05-01

We present preliminary results from the analysis of 16 bright bursts that have been observed by the EGRET NaI calorimeter, or TASC. Seven bursts have been imaged in the EGRET spark chamber above 30 MeV, but in most cases the TASC data gives the highest energy spectra available for these bursts. The TASC can obtain spectral and rate information for bursts well outside the field of view of the EGRET spark chambers, and is sensitive in the energy range from 1 to 200 MeV. The spectra for these bursts are mostly consistent with a simple power law with spectral index in the range from 1.7 to 3.7, with several of the brighter bursts showing emission past 100 MeV. No high energy cutoff has been observed. These high energy photons offer important clues to the physical processes involved at the origin of burst emission. For bursts at cosmological distances extremely high bulk Lorentz factors are implied by the presence of MeV and GeV photons which have not been attenuated by pair production with the lower energy photons from the source.

Towards an integrative model of C4 photosynthetic subtypes: insights from comparative transcriptome analysis of NAD-ME, NADP-ME, and PEP-CK C4 species.

PubMed

Bräutigam, Andrea; Schliesky, Simon; Külahoglu, Canan; Osborne, Colin P; Weber, Andreas P M

2014-07-01

C4 photosynthesis affords higher photosynthetic carbon conversion efficiency than C3 photosynthesis and it therefore represents an attractive target for engineering efforts aiming to improve crop productivity. To this end, blueprints are required that reflect C4 metabolism as closely as possible. Such blueprints have been derived from comparative transcriptome analyses of C3 species with related C4 species belonging to the NAD-malic enzyme (NAD-ME) and NADP-ME subgroups of C4 photosynthesis. However, a comparison between C3 and the phosphoenolpyruvate carboxykinase (PEP-CK) subtype of C4 photosynthesis is still missing. An integrative analysis of all three C4 subtypes has also not been possible to date, since no comparison has been available for closely related C3 and PEP-CK C4 species. To generate the data, the guinea grass Megathyrsus maximus, which represents a PEP-CK species, was analysed in comparison with a closely related C3 sister species, Dichanthelium clandestinum, and with publicly available sets of RNA-Seq data from C4 species belonging to the NAD-ME and NADP-ME subgroups. The data indicate that the core C4 cycle of the PEP-CK grass M. maximus is quite similar to that of NAD-ME species with only a few exceptions, such as the subcellular location of transfer acid production and the degree and pattern of up-regulation of genes encoding C4 enzymes. One additional mitochondrial transporter protein was associated with the core cycle. The broad comparison identified sucrose and starch synthesis, as well as the prevention of leakage of C4 cycle intermediates to other metabolic pathways, as critical components of C4 metabolism. Estimation of intercellular transport fluxes indicated that flux between cells is increased by at least two orders of magnitude in C4 species compared with C3 species. In contrast to NAD-ME and NADP-ME species, the transcription of photosynthetic electron transfer proteins was unchanged in PEP-CK. In summary, the PEP-CK blueprint of M

Towards an integrative model of C4 photosynthetic subtypes: insights from comparative transcriptome analysis of NAD-ME, NADP-ME, and PEP-CK C4 species

PubMed Central

Bräutigam, Andrea; Schliesky, Simon; Külahoglu, Canan; Osborne, Colin P.; Weber, Andreas P.M.

2014-01-01

C4 photosynthesis affords higher photosynthetic carbon conversion efficiency than C3 photosynthesis and it therefore represents an attractive target for engineering efforts aiming to improve crop productivity. To this end, blueprints are required that reflect C4 metabolism as closely as possible. Such blueprints have been derived from comparative transcriptome analyses of C3 species with related C4 species belonging to the NAD-malic enzyme (NAD-ME) and NADP-ME subgroups of C4 photosynthesis. However, a comparison between C3 and the phosphoenolpyruvate carboxykinase (PEP-CK) subtype of C4 photosynthesis is still missing. An integrative analysis of all three C4 subtypes has also not been possible to date, since no comparison has been available for closely related C3 and PEP-CK C4 species. To generate the data, the guinea grass Megathyrsus maximus, which represents a PEP-CK species, was analysed in comparison with a closely related C3 sister species, Dichanthelium clandestinum, and with publicly available sets of RNA-Seq data from C4 species belonging to the NAD-ME and NADP-ME subgroups. The data indicate that the core C4 cycle of the PEP-CK grass M. maximus is quite similar to that of NAD-ME species with only a few exceptions, such as the subcellular location of transfer acid production and the degree and pattern of up-regulation of genes encoding C4 enzymes. One additional mitochondrial transporter protein was associated with the core cycle. The broad comparison identified sucrose and starch synthesis, as well as the prevention of leakage of C4 cycle intermediates to other metabolic pathways, as critical components of C4 metabolism. Estimation of intercellular transport fluxes indicated that flux between cells is increased by at least two orders of magnitude in C4 species compared with C3 species. In contrast to NAD-ME and NADP-ME species, the transcription of photosynthetic electron transfer proteins was unchanged in PEP-CK. In summary, the PEP-CK blueprint of M

Approche au diagnostic de la maladie cœliaque chez les patients ayant une faible densité minérale osseuse ou des fractures de fragilité

PubMed Central

Rios, Lorena P.; Khan, Aliya; Sultan, Muhammad; McAssey, Karen; Fouda, Mona A.; Armstrong, David

2013-01-01

Résumé Objectif Présenter aux cliniciens une mise à jour sur le diagnostic de la maladie cœliaque (MC), ainsi que des recommandations sur les indications de procéder au dépistage de la MC chez les patients présentant une faible densité minérale osseuse (DMO) ou des fractures de fragilité. Qualité des données Un groupe de travail multidisciplinaire a élaboré des questions cliniquement pertinentes relativement au diagnostic de la MC servant de fondement à une recherche documentaire dans les bases de données MEDLINE, EMBASE et CENTRAL (de janvier 2000 à janvier 2009) à l’aide des mots clés en anglais celiac disease, osteoporosis, osteopenia, low bone mass et fracture. Les ouvrages scientifiques existants comportent des études de niveaux I et II. Message principal La prévalence estimée de la MC asymptomatique est de 2 % à 3 % chez les personnes qui ont une faible DMO. Par ailleurs, un dépistage ciblé est recommandé pour les patients qui ont des T-scores de −1,0 ou moins à la colonne vertébrale ou aux hanches ou des antécédents de fractures de fragilité associées à des symptômes ou à des problèmes reliés à la MC, des antécédents familiaux de MC ou de bas niveaux de calcium urinaire, une insuffisance en vitamine D et des niveaux à la hausse d’hormones parathyroïdiennes en dépit d’un apport suffisant en calcium et en vitamine D. Le dépistage de la MC devrait se faire pendant que le sujet consomme un régime alimentaire contenant du gluten. On procède au dépistage initial par le dosage d’immunoglobuline (Ig) A antitransglutaminase en utilisant la transglutaminase tissulaire humaine recombinante ou une autre transglutaminase tissulaire, en association avec l’immunofluorescence des IgA anti-endomysium. Une biopsie du duodénum est nécessaire pour confirmer le diagnostic de la MC. Le typage des antigènes des leucocytes humains peut aider à confirmer ou à exclure le diagnostic de la MC dans les cas où la s

Research Trend Visualization by MeSH Terms from PubMed.

PubMed

Yang, Heyoung; Lee, Hyuck Jai

2018-05-30

Motivation : PubMed is a primary source of biomedical information comprising search tool function and the biomedical literature from MEDLINE which is the US National Library of Medicine premier bibliographic database, life science journals and online books. Complimentary tools to PubMed have been developed to help the users search for literature and acquire knowledge. However, these tools are insufficient to overcome the difficulties of the users due to the proliferation of biomedical literature. A new method is needed for searching the knowledge in biomedical field. Methods : A new method is proposed in this study for visualizing the recent research trends based on the retrieved documents corresponding to a search query given by the user. The Medical Subject Headings (MeSH) are used as the primary analytical element. MeSH terms are extracted from the literature and the correlations between them are calculated. A MeSH network, called MeSH Net, is generated as the final result based on the Pathfinder Network algorithm. Results : A case study for the verification of proposed method was carried out on a research area defined by the search query (immunotherapy and cancer and "tumor microenvironment"). The MeSH Net generated by the method is in good agreement with the actual research activities in the research area (immunotherapy). Conclusion : A prototype application generating MeSH Net was developed. The application, which could be used as a "guide map for travelers", allows the users to quickly and easily acquire the knowledge of research trends. Combination of PubMed and MeSH Net is expected to be an effective complementary system for the researchers in biomedical field experiencing difficulties with search and information analysis.

Observations of gamma radiation between 0.4 MeV and 7 MeV at balloon altitudes using a Compton telescope

NASA Technical Reports Server (NTRS)

Lockwood, J. A.; Webber, W. R.; Friling, L. A.; Macri, J.; Hsieh, L.

1981-01-01

Balloon-borne measurements of the atmospheric and diffuse gamma-ray flux in the energy range 0.4-7.0 MeV with a Compton telescope, which included pulse-shape discrimination of the first scattering detector and a time-of-flight system between the first and second detector elements, are reported. Comparison of the diffuse cosmic gamma-ray flux to the atmospheric gamma rays indicates that 0.2-5.0 MeV is the optimum energy range for measurements made at the top of the earth's atmosphere. The measured total atmospheric gamma-ray flux between zero and 40 deg has an energy spectrum that agrees with the calculations of Ling (1975). Observations indicate that the ratio of the diffuse to atmospheric gamma ray fluxes at 3.5 g/sq cm is a maximum, about 1.0, between 0.7 and 3.0 MeV.

Idaho AASHTOWare pavement ME design user's guide, version 1.1.

DOT National Transportation Integrated Search

2014-03-01

The AASHTOWare Pavement ME Design procedure is based on mechanistic-empirical (M-E) design concepts. This means that the design procedure calculates pavement responses such as stresses, strains, and deflections under axle loads and climatic condition...

Nuclear Resonance Fluorescence of U-235 above 3 MeV

DOE Office of Scientific and Technical Information (OSTI.GOV)

Warren, Glen A.; Caggiano, Joseph A.; Miller, Erin A.

Pacific Northwest National Laboratory and Passport Systems have collaborated to conduct measurements to search for a nuclear resonance fluorescence response of U-235 from 3 to 5 MeV using an 8 g sample of highly enriched uranium. These new measurements complement previously reported measurements below 3 MeV. Preliminary analysis indicates that no strong resonances exist for U-235 in this energy range. A second set of measurements focused on a signature search in the 5 to 10 MeV range is still under analysis.

The triterpenoid CDDO-Me inhibits bleomycin-induced lung inflammation and fibrosis.

PubMed

Kulkarni, Ajit A; Thatcher, Thomas H; Hsiao, Hsi-Min; Olsen, Keith C; Kottmann, Robert Matthew; Morrissette, Jason; Wright, Terry W; Phipps, Richard P; Sime, Patricia J

2013-01-01

Pulmonary Fibrosis (PF) is a devastating progressive disease in which normal lung structure and function is compromised by scarring. Lung fibrosis can be caused by thoracic radiation, injury from chemotherapy and systemic diseases such as rheumatoid arthritis that involve inflammatory responses. CDDO-Me (Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate, Bardoxolone methyl) is a novel triterpenoid with anti-fibrotic and anti-inflammatory properties as shown by our in vitro studies. Based on this evidence, we hypothesized that CDDO-Me would reduce lung inflammation, fibrosis and lung function impairment in a bleomycin model of lung injury and fibrosis. To test this hypothesis, mice received bleomycin via oropharyngeal aspiration (OA) on day zero and CDDO-Me during the inflammatory phase from days -1 to 9 every other day. Bronchoalveolar lavage fluid (BALF) and lung tissue were harvested on day 7 to evaluate inflammation, while fibrosis and lung function were evaluated on day 21. On day 7, CDDO-Me reduced total BALF protein by 50%, alveolar macrophage infiltration by 40%, neutrophil infiltration by 90% (p≤0.01), inhibited production of the inflammatory cytokines KC and IL-6 by over 90% (p≤0.001), and excess production of the pro-fibrotic cytokine TGFβ by 50%. CDDO-Me also inhibited α-smooth muscle actin and fibronectin mRNA by 50% (p≤0.05). On day 21, CDDO-Me treatment reduced histological fibrosis, collagen deposition and αSMA production. Lung function was significantly improved at day 21 by treatment with CDDO-Me, as demonstrated by respiratory rate and dynamic compliance. These new findings reveal that CDDO-Me exhibits potent anti-fibrotic and anti-inflammatory properties in vivo. CDDO-Me is a potential new class of drugs to arrest inflammation and ameliorate fibrosis in patients who are predisposed to lung injury and fibrosis incited by cancer treatments (e.g. chemotherapy and radiation) and by systemic autoimmune diseases.

The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis

PubMed Central

Kulkarni, Ajit A.; Thatcher, Thomas H.; Hsiao, Hsi-Min; Olsen, Keith C.; Kottmann, Robert Matthew; Morrissette, Jason; Wright, Terry W.; Phipps, Richard P.; Sime, Patricia J.

2013-01-01

Pulmonary Fibrosis (PF) is a devastating progressive disease in which normal lung structure and function is compromised by scarring. Lung fibrosis can be caused by thoracic radiation, injury from chemotherapy and systemic diseases such as rheumatoid arthritis that involve inflammatory responses. CDDO-Me (Methyl 2-cyano-3,12-dioxooleana-1,9(11)dien-28-oate, Bardoxolone methyl) is a novel triterpenoid with anti-fibrotic and anti-inflammatory properties as shown by our in vitro studies. Based on this evidence, we hypothesized that CDDO-Me would reduce lung inflammation, fibrosis and lung function impairment in a bleomycin model of lung injury and fibrosis. To test this hypothesis, mice received bleomycin via oropharyngeal aspiration (OA) on day zero and CDDO-Me during the inflammatory phase from days -1 to 9 every other day. Bronchoalveolar lavage fluid (BALF) and lung tissue were harvested on day 7 to evaluate inflammation, while fibrosis and lung function were evaluated on day 21. On day 7, CDDO-Me reduced total BALF protein by 50%, alveolar macrophage infiltration by 40%, neutrophil infiltration by 90% (p≤0.01), inhibited production of the inflammatory cytokines KC and IL-6 by over 90% (p≤0.001), and excess production of the pro-fibrotic cytokine TGFβ by 50%. CDDO-Me also inhibited α-smooth muscle actin and fibronectin mRNA by 50% (p≤0.05). On day 21, CDDO-Me treatment reduced histological fibrosis, collagen deposition and αSMA production. Lung function was significantly improved at day 21 by treatment with CDDO-Me, as demonstrated by respiratory rate and dynamic compliance. These new findings reveal that CDDO-Me exhibits potent anti-fibrotic and anti-inflammatory properties in vivo. CDDO-Me is a potential new class of drugs to arrest inflammation and ameliorate fibrosis in patients who are predisposed to lung injury and fibrosis incited by cancer treatments (e.g. chemotherapy and radiation) and by systemic autoimmune diseases. PMID:23741300

Le syndrome du canal d’Alcock ou névralgie pudendale : un diagnostic à ne pas méconnaître

PubMed Central

Ziouziou, Imad; Bennani, Hassan; Zizi, Mohamed; Karmouni, Tarik; Khader, Khalid El; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

2013-01-01

Résumé Le syndrome du canal d’Alcock – ou névralgie pudendale – est lié à la compression chronique du nerf pudendal dans la fossette ischiorectale ou au niveau du ligament sacroépineux. Le diagnostic du syndrome d’Alcock est surtout clinique. Les examens complémentaires sont dominés par les explorations électrophysiologiques et le test de bloc anesthésique. Le diagnostic repose sur des critères bien précis, soit les critères de Nantes. La prise en charge doit être globale, comprenant un traitement médicamenteux, des infiltrations, des techniques de neuromodulation, et dans les cas graves ou résistants, un traitement chirurgical qui consiste à libérer le nerf pudendal. Les névralgies pudendales peuvent être rencontrées après traitement d’une incontinence urinaire d’effort par bande-lettes sous-urétrales (TVT). Ce syndrome motive des consultations en urologie, car la douleur intéresse le territoire du périnée et des organes génitaux. Des signes urinaires peuvent aussi accompagner cette douleur. Il est donc judicieux de connaître cette pathologie. PMID:23914265

Genome-wide identification, classification, and analysis of NADP-ME family members from 12 crucifer species.

PubMed

Tao, Peng; Guo, Weiling; Li, Biyuan; Wang, Wuhong; Yue, Zhichen; Lei, Juanli; Zhao, Yanting; Zhong, Xinmin

2016-06-01

NADP-dependent malic enzymes (NADP-MEs) play essential roles in both normal development and stress responses in plants. Here, genome-wide analysis was performed to identify 65 putative NADP-ME genes from 12 crucifer species. These NADP-ME genes were grouped into five categories of syntenic orthologous genes and were divided into three clades of a phylogenic tree. Promoter motif analysis showed that NADP-ME1 genes in Group IV were more conserved with each other than the other NADP-ME genes in Groups I and II. A nucleotide motif involved in ABA responses, desiccation and seed development was found in the promoters of most NADP-ME1 genes. Generally, the NADP-ME genes of Brassica rapa, B. oleracea and B. napus had less introns than their corresponding Arabidopsis orthologs. In these three Brassica species, the NADP-ME genes derived from the least fractionated subgenome have lost less introns than those from the medium fractionated and most fractionated subgenomes. BrNADP-ME1 showed the highest expression in petals and mature embryos. Two paralogous NADP-ME2 genes (BrNADP-ME2a and BrNADP-ME2b) shared similar expression profiles and differential expression levels. BrNADP-ME3 showed down-regulation during embryogenesis and reached its lowest expression in early cotyledonary embryos. BrNADP-ME4 was expressed widely in multiple organs and showed high expression during the whole embryogenesis process. Different NADP-ME genes of B. rapa showed differential gene expression profiles in young leaves after ABA treatment or cold stress. Our genome-wide identification and characterization of NADP-ME genes extend our understanding of the evolution or function of this family in Brassicaceae.

78 FR 10691 - Proposed Collection; Comment Request for the MeF letter

Federal Register 2010, 2011, 2012, 2013, 2014

2013-02-14

... MeF letter AGENCY: Internal Revenue Service (IRS), Treasury. ACTION: Notice and request for comments... the MeF letter, Mondernized e-File--Non-compliance with Mandate for Large Corporations to file... Number: MeF letter. Abstract: Service will contact those taxpayers who file paper income tax returns to...

50 CFR 14.94 - What fees apply to me?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 50 Wildlife and Fisheries 1 2011-10-01 2011-10-01 false What fees apply to me? 14.94 Section 14.94 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING... What fees apply to me? (a) Import/export license application fees. You must pay the application and...

50 CFR 14.94 - What fees apply to me?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 50 Wildlife and Fisheries 1 2013-10-01 2013-10-01 false What fees apply to me? 14.94 Section 14.94 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING... What fees apply to me? (a) Import/export license application fees. You must pay the application and...

50 CFR 14.94 - What fees apply to me?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 50 Wildlife and Fisheries 1 2012-10-01 2012-10-01 false What fees apply to me? 14.94 Section 14.94 Wildlife and Fisheries UNITED STATES FISH AND WILDLIFE SERVICE, DEPARTMENT OF THE INTERIOR TAKING... What fees apply to me? (a) Import/export license application fees. You must pay the application and...

Sustained >100 MeV Gamma-Ray Emission: A Monitor for >300 MeV SEP Protons at the Sun

NASA Astrophysics Data System (ADS)

Share, G. H.; Murphy, R. J.

2017-12-01

Solar γ radiation is the product of proton and ion interactions in the solar atmosphere. The spectrum and temporal characteristics of the emission provides fundamental information on the ions at the Sun. Until the launch of the Fermi satellite, with its Large Area Telescope (LAT) sensitive to radiation above 100 MeV, most of the γ-ray observations were made in the nuclear energy range with radiation arising from interaction of one to tens of MeV ions produced in solar flares. Since 2008 the LAT has detected 30 high-energy γ-ray events with temporal and spectral characteristics that are distinct from the associated solar flare. We call this radiation Sustained Gamma-Ray Emission (SGRE) and briefly summarize its characteristics reported in a recent paper. The γ-ray spectra are consistent with pion decay radiation produced by protons above 300 MeV. The onset of the radiation most often occurs after the impulsive flare and the emission can last several hours. We find that the number of protons responsible for the SGRE is typically more than 10 times the number of flare-accelerated protons. These characteristics require that there be an additional source of energy to accelerate the protons to hundreds of MeV to produce the SGRE. As 28 of the 30 SGRE events are accompanied by fast CMEs, it is likely that these protons are accelerated by the same shock that produces gradual SEPs. We find that the number of protons >500 MeV in the accompanying SEPs is typically about 50-100 times the number of protons that return to the Sun to produce the SGRE. There also appear to be correlations between the numbers of SEP and SGRE protons and durations of >100 MeV SEP proton and SGRE events. We find that for all SGRE events where there were flare observations, the accompanying impulsive X-radiation reached energies >100 keV. In a limited study of 18 solar events with CME speeds >800 km/s we also find that the median SEP proton flux is 25 times higher when flare hard X-rays exceed 100

75 FR 8485 - Revocation of Class D and E Airspace; Brunswick, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2010-02-25

...-0981; Airspace Docket No. 09-ANE-105] Revocation of Class D and E Airspace; Brunswick, ME AGENCY... and E Airspace at Brunswick NAS Airport, Brunswick, ME, as the airport has closed and the associated... Brunswick NAS Airport in Brunswick, ME has closed in compliance with the 2005 Base Realignment and Closure...

77 FR 27666 - Proposed Amendment of Class E Airspace; Bar Harbor, ME

Federal Register 2010, 2011, 2012, 2013, 2014

2012-05-11

...-1366; Airspace Docket No. 11-ANE-13] Proposed Amendment of Class E Airspace; Bar Harbor, ME AGENCY... action proposes to amend Class E Airspace at Bar Harbor, ME, as the Surry Non-Directional Radio Beacon... Airport, Bar Harbor, ME. Airspace reconfiguration is necessary due to the decommissioning of the Surry NDB...

MeV dark matter complementarity and the dark photon portal

NASA Astrophysics Data System (ADS)

Dutra, Maíra; Lindner, Manfred; Profumo, Stefano; Queiroz, Farinaldo S.; Rodejohann, Werner; Siqueira, Clarissa

2018-03-01

We discuss the phenomenology of an MeV-scale Dirac fermion coupled to the Standard Model through a dark photon with kinetic mixing with the electromagnetic field. We compute the dark matter relic density and explore the interplay of direct detection and accelerator searches for dark photons. We show that precise measurements of the temperature and polarization power spectra of the Cosmic Microwave Background Radiation lead to stringent constraints, leaving a small window for the thermal production of this MeV dark matter candidate. The forthcoming MeV gamma-ray telescope e-ASTROGAM will offer important and complementary opportunities to discover dark matter particles with masses below ~ 10 MeV . Lastly, we discuss how a late-time inflation episode and freeze-in production could conspire to yield the correct relic density while being consistent with existing and future constraints.

L’identification et traitement du trouble panique avec ou sans agoraphobie

PubMed Central

Foldes-Busque, Guillaume; Marchand, André; Landry, Pierre

2007-01-01

RÉSUMÉ OBJECTIF Renseigner les médecins de première ligne au sujet de l’identification précoce, du diagnostic et du traitement du trouble panique avec ou sans agoraphobie (TP/A). QUALITÉ DES DONNÉES Les données et recommandations présentées proviennent d’une recension des écrits scientifiques réalisée via les banques de données PsycLIT, PsyINFO et MEDLINE (1985 à 2006) en utilisant les descripteurs panic disorder, psychotherapy, psychosocial treatment, treatment et pharmacotherapy. Les recommandations formulées par les auteurs s’appuient sur des données probantes provenant d’études d’excellente qualité. Les informations concernant le diagnostic et l’évaluation du TP/A proviennent d’études épidémiologiques récentes, de consensus et d’opinions d’experts. PRINCIPAL MESSAGE Le TP/A est un trouble psychiatrique souvent rencontré en médecine de première ligne, mais il est fréquemment sous-diagnostiqué et sous-traité. L’identification précoce de ce trouble demande une attention particulière aux symptômes médicalement inexpliqués et, le cas échéant, le médecin doit utiliser des questions spécifiques permettant d’identifier d’éventuelles attaques de panique et de cerner leur signification pour le patient. Le traitement de premier choix pour ce trouble est une psychothérapie d’orientation cognitivo-comportementale administrée par un psychologue ou un psychiatre spécialisé. Si de telles ressources ne sont pas disponibles, le médecin peut opter pour un traitement psychopharmacologique. CONCLUSION Les médecins de famille peuvent jouer un rôle central dans l’identification et le traitement des patients souffrant d’un TP/A. PMID:17934032

Upper limit on the inner radiation belt MeV electron intensity.

PubMed

Li, X; Selesnick, R S; Baker, D N; Jaynes, A N; Kanekal, S G; Schiller, Q; Blum, L; Fennell, J; Blake, J B

2015-02-01

No instruments in the inner radiation belt are immune from the unforgiving penetration of the highly energetic protons (tens of MeV to GeV). The inner belt proton flux level, however, is relatively stable; thus, for any given instrument, the proton contamination often leads to a certain background noise. Measurements from the Relativistic Electron and Proton Telescope integrated little experiment on board Colorado Student Space Weather Experiment CubeSat, in a low Earth orbit, clearly demonstrate that there exist sub-MeV electrons in the inner belt because their flux level is orders of magnitude higher than the background, while higher-energy electron (>1.6 MeV) measurements cannot be distinguished from the background. Detailed analysis of high-quality measurements from the Relativistic Electron and Proton Telescope on board Van Allen Probes, in a geo-transfer-like orbit, provides, for the first time, quantified upper limits on MeV electron fluxes in various energy ranges in the inner belt. These upper limits are rather different from flux levels in the AE8 and AE9 models, which were developed based on older data sources. For 1.7, 2.5, and 3.3 MeV electrons, the upper limits are about 1 order of magnitude lower than predicted model fluxes. The implication of this difference is profound in that unless there are extreme solar wind conditions, which have not happened yet since the launch of Van Allen Probes, significant enhancements of MeV electrons do not occur in the inner belt even though such enhancements are commonly seen in the outer belt. Quantified upper limit of MeV electrons in the inner beltActual MeV electron intensity likely much lower than the upper limitMore detailed understanding of relativistic electrons in the magnetosphere.

Upper limit on the inner radiation belt MeV electron intensity

PubMed Central

Li, X; Selesnick, RS; Baker, DN; Jaynes, AN; Kanekal, SG; Schiller, Q; Blum, L; Fennell, J; Blake, JB

2015-01-01

No instruments in the inner radiation belt are immune from the unforgiving penetration of the highly energetic protons (tens of MeV to GeV). The inner belt proton flux level, however, is relatively stable; thus, for any given instrument, the proton contamination often leads to a certain background noise. Measurements from the Relativistic Electron and Proton Telescope integrated little experiment on board Colorado Student Space Weather Experiment CubeSat, in a low Earth orbit, clearly demonstrate that there exist sub-MeV electrons in the inner belt because their flux level is orders of magnitude higher than the background, while higher-energy electron (>1.6 MeV) measurements cannot be distinguished from the background. Detailed analysis of high-quality measurements from the Relativistic Electron and Proton Telescope on board Van Allen Probes, in a geo-transfer-like orbit, provides, for the first time, quantified upper limits on MeV electron fluxes in various energy ranges in the inner belt. These upper limits are rather different from flux levels in the AE8 and AE9 models, which were developed based on older data sources. For 1.7, 2.5, and 3.3 MeV electrons, the upper limits are about 1 order of magnitude lower than predicted model fluxes. The implication of this difference is profound in that unless there are extreme solar wind conditions, which have not happened yet since the launch of Van Allen Probes, significant enhancements of MeV electrons do not occur in the inner belt even though such enhancements are commonly seen in the outer belt. Key Points Quantified upper limit of MeV electrons in the inner belt Actual MeV electron intensity likely much lower than the upper limit More detailed understanding of relativistic electrons in the magnetosphere PMID:26167446

Comparison of bactericidal efficiency of 7.5 MeV X-rays, gamma-rays, and 10 MeV e-beams

NASA Astrophysics Data System (ADS)

Song, Beom-Seok; Lee, Yunjong; Moon, Byeong-Geum; Go, Seon-Min; Park, Jong-Heum; Kim, Jae-Kyung; Jung, Koo; Kim, Dong-Ho; Ryu, Sang-Ryeol

2016-08-01

This study was performed to verify the feasibility of 7.5 MeV X-rays for food pasteurization through a comparison of the bactericidal efficiency with those of other sources for selected bacterial pathogens. No significant differences were observed between the overall bactericidal efficiency for beef-inoculated pathogens based on the uncertainty of the absorbed dose and variations in bacterial counts. This result supported that all three irradiation sources were effective for inactivation of food-borne bacteria and that 7.5 MeV X-rays may be used for food pasteurization.

PRiME: integrating professional responsibility into the engineering curriculum.

PubMed

Moore, Christy; Hart, Hillary; Randall, D'Arcy; Nichols, Steven P

2006-04-01

Engineering educators have long discussed the need to teach professional responsibility and the social context of engineering without adding to overcrowded curricula. One difficulty we face is the lack of appropriate teaching materials that can fit into existing courses. The PRiME (Professional Responsibility Modules for Engineering) Project (http://www.engr.utexas.edu/ethics/primeModules.cfm) described in this paper was initiated at the University of Texas, Austin to provide web-based modules that could be integrated into any undergraduate engineering class. Using HPL (How People Learn) theory, PRiME developed and piloted four modules during the academic year 2004-2005. This article introduces the modules and the pilot, outlines the assessment process, analyzes the results, and describes how the modules are being revised in light of the initial assessment. In its first year of development and testing, PRiME made significant progress towards meeting its objectives. The PRiME Project can strengthen engineering education by providing faculty with an effective system for engaging students in learning about professional responsibility.

Relation of Anxiety and Depressive Symptoms to Coronary Artery Calcium (from the ELSA-Brasil Baseline Data).

PubMed

Santos, Itamar S; Bittencourt, Marcio S; Rocco, Priscila T; Pereira, Alexandre C; Barreto, Sandhi M; Brunoni, André R; Goulart, Alessandra C; Blaha, Michael J; Lotufo, Paulo A; Bensenor, Isabela M

2016-07-15

Previous studies of the association between symptoms of anxiety or depression and coronary artery calcium (CAC) have produced heterogeneous results. Our aim was to investigate whether psychopathological symptoms were associated with CAC in a cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil) baseline. We analyzed data from 4,279 ELSA-Brasil subjects (aged 35 to 74 years) from the São Paulo site without previous cardiovascular disease who underwent CAC score assessment at baseline. Prevalent CAC was defined as a CAC score >0. Anxiety and depressive symptoms were assessed using the Clinical Interview Schedule-Revised (CIS-R). We built binary logistic regression models to determine whether CIS-R scores, anxiety, or depression were associated with prevalent CAC. Prevalent CAC was found in 1,211 subjects (28.3%). After adjustment for age and gender, a direct association between CIS-R scores and prevalent CAC was revealed (odds ratio for 1-SD increase: 1.12; 95% confidence interval [CI] 1.04 to 1.22). This association persisted after multivariate adjustment (odds ratio for 1-SD increase 1.11; 95% CI 1.02 to 1.20). No independent associations were found for specific diagnoses of anxiety or depression and prevalent CAC. In post hoc models, a significant interaction term (p = 0.019) suggested a stronger association in older subjects. In conclusion, psychopathological symptoms were directly associated with coronary atherosclerosis in the ELSA-Brasil baseline in adjusted models, and this association seems to be stronger in older subjects. Copyright © 2016 Elsevier Inc. All rights reserved.

Detection of sub-MeV dark matter with three-dimensional Dirac materials

NASA Astrophysics Data System (ADS)

Hochberg, Yonit; Kahn, Yonatan; Lisanti, Mariangela; Zurek, Kathryn M.; Grushin, Adolfo G.; Ilan, Roni; Griffin, Sinéad M.; Liu, Zhen-Fei; Weber, Sophie F.; Neaton, Jeffrey B.

2018-01-01

We propose the use of three-dimensional Dirac materials as targets for direct detection of sub-MeV dark matter. Dirac materials are characterized by a linear dispersion for low-energy electronic excitations, with a small band gap of O (meV ) if lattice symmetries are broken. Dark matter at the keV scale carrying kinetic energy as small as a few meV can scatter and excite an electron across the gap. Alternatively, bosonic dark matter as light as a few meV can be absorbed by the electrons in the target. We develop the formalism for dark matter scattering and absorption in Dirac materials and calculate the experimental reach of these target materials. We find that Dirac materials can play a crucial role in detecting dark matter in the keV to MeV mass range that scatters with electrons via a kinetically mixed dark photon, as the dark photon does not develop an in-medium effective mass. The same target materials provide excellent sensitivity to absorption of light bosonic dark matter in the meV to hundreds of meV mass range, superior to all other existing proposals when the dark matter is a kinetically mixed dark photon.

Detection of sub-MeV dark matter with three-dimensional Dirac materials

DOE PAGES

Hochberg, Yonit; Kahn, Yonatan; Lisanti, Mariangela; ...

2018-01-08

Here, we propose the use of three-dimensional Dirac materials as targets for direct detection of sub-MeV dark matter. Dirac materials are characterized by a linear dispersion for low-energy electronic excitations, with a small band gap of Ο(meV) if lattice symmetries are broken. Dark matter at the keV scale carrying kinetic energy as small as a few meV can scatter and excite an electron across the gap. Alternatively, bosonic dark matter as light as a few meV can be absorbed by the electrons in the target. We develop the formalism for dark matter scattering and absorption in Dirac materials and calculatemore » the experimental reach of these target materials. We find that Dirac materials can play a crucial role in detecting dark matter in the keV to MeV mass range that scatters with electrons via a kinetically mixed dark photon, as the dark photon does not develop an in-medium effective mass. The same target materials provide excellent sensitivity to absorption of light bosonic dark matter in the meV to hundreds of meV mass range, superior to all other existing proposals when the dark matter is a kinetically mixed dark photon.« less

Detection of sub-MeV dark matter with three-dimensional Dirac materials

DOE Office of Scientific and Technical Information (OSTI.GOV)

Hochberg, Yonit; Kahn, Yonatan; Lisanti, Mariangela

Here, we propose the use of three-dimensional Dirac materials as targets for direct detection of sub-MeV dark matter. Dirac materials are characterized by a linear dispersion for low-energy electronic excitations, with a small band gap of Ο(meV) if lattice symmetries are broken. Dark matter at the keV scale carrying kinetic energy as small as a few meV can scatter and excite an electron across the gap. Alternatively, bosonic dark matter as light as a few meV can be absorbed by the electrons in the target. We develop the formalism for dark matter scattering and absorption in Dirac materials and calculatemore » the experimental reach of these target materials. We find that Dirac materials can play a crucial role in detecting dark matter in the keV to MeV mass range that scatters with electrons via a kinetically mixed dark photon, as the dark photon does not develop an in-medium effective mass. The same target materials provide excellent sensitivity to absorption of light bosonic dark matter in the meV to hundreds of meV mass range, superior to all other existing proposals when the dark matter is a kinetically mixed dark photon.« less

No decision about me without me: concordance operationalised.

PubMed

Snowden, Austyn; Marland, Glenn

2013-05-01

To demonstrate that concordance can be operationalised to the benefit of patients. Concordance can be understood as a composite of knowledge, health beliefs and collaboration. In discussing any clinical decision, it would be ideal if different views could be incorporated to reach the most coherent decision. This is a definition of concordance, a widely agreed ideal in nursing. There are limits, however, that make the practice of concordance problematic. Sometimes there is little time or willingness to discuss issues in depth. Some views of the world are considered more worthy than others. As a consequence, clinical guidelines currently prioritise easier to measure outcomes of negotiation, such as adherence. This discursive article argues that prioritising adherence is a fundamental error, incoherent with current strategic rhetoric such as the Department of Health's 'no decision about me without me'. The impact of prioritising concordance is contrasted with adherence-based interventions. Where adherence is a goal of treatment, non-adherence is considered problematic. This value judgment is not useful and does not occur in a consultation that prioritises concordance. However, concordance is difficult to translate into clinical practice. This article shows that concordance can be operationalised by considering it a composite of health beliefs, knowledge and collaboration. The main thesis is that different behaviours can always be incorporated into a concordance framework. This negates the necessity for adherence as an endpoint in itself. Fifty per cent of people do not take medicines as prescribed. Interventions focused towards improving adherence are only ever partially successful. This is because it presupposes the clinician is right. Concordance by contrast is more coherent with person centred care and thus more likely to generate clinically meaningful outcomes for patients. © 2012 Blackwell Publishing Ltd.

Femtosecond time-resolved MeV electron diffraction

DOE PAGES

Zhu, Pengfei; Zhu, Y.; Hidaka, Y.; ...

2015-06-02

We report the experimental demonstration of femtosecond electron diffraction using high-brightness MeV electron beams. High-quality, single-shot electron diffraction patterns for both polycrystalline aluminum and single-crystal 1T-TaS 2 are obtained utilizing a 5 fC (~3 × 10 4 electrons) pulse of electrons at 2.8 MeV. The high quality of the electron diffraction patterns confirms that electron beam has a normalized emittance of ~50 nm rad. The transverse and longitudinal coherence length is ~11 and ~2.5 nm, respectively. The timing jitter between the pump laser and probe electron beam was found to be ~100 fs (rms). The temporal resolution is demonstrated bymore » observing the evolution of Bragg and superlattice peaks of 1T-TaS 2 following an 800 nm optical pump and was found to be 130 fs. Lastly, our results demonstrate the advantages of MeV electrons, including large elastic differential scattering cross-section and access to high-order reflections, and the feasibility of ultimately realizing below 10 fs time-resolved electron diffraction.« less

Neutron-induced fission cross section of 242Pu from 15 MeV to 20 MeV

NASA Astrophysics Data System (ADS)

Jovančević, N.; Salvador-Castineira, P.; Daraban, L.; Vidali, M.; Heyse, J.; Oberstedt, S.; Hambsch, F.-J.; Bonaldi, C.; Geerts, W.

2017-09-01

Accurate nuclear-data needs in the fast-neutron-energy region have been recently addressed for the development of next generation nuclear power plants (GEN-IV) by the OECD Nuclear Energy Agency (NEA). This sensitivity study has shown that of particular interest is the 242Pu(n,f) cross section for fast reactor systems. Measurements have been performed with quasi-monoenergetic neutrons in the energy range from 15 MeV to 20 MeV produced by the Van de Graaff accelerator of the JRC-Geel. A twin Frisch-grid ionization chamber has been used in a back-to-back configuration as fission fragment detector. The 242Pu(n,f) cross section has been normalized to 238U(n,f) cross section data. The results were compared with existing literature data and show acceptable agreement within 5%.

Ethylene Responsive Factor MeERF72 Negatively Regulates Sucrose synthase 1 Gene in Cassava.

PubMed

Liu, Chen; Chen, Xin; Ma, Ping'an; Zhang, Shengkui; Zeng, Changying; Jiang, Xingyu; Wang, Wenquan

2018-04-25

Cassava, an important food and industrial crop globally, is characterized by its powerful starch accumulation in its storage root. However, the underlying molecular mechanism for this feature remains unclear. Sucrose synthase initializes the conversion of sucrose to starch, and, to a certain extent, its enzyme activity can represent sink strength. To understand the modulation of MeSus gene family, the relatively high expressed member in storage root, MeSus1 , its promoter was used as bait to screen cassava storage root full-length cDNA library through a yeast one-hybrid system. An ethylene responsive factor cDNA, designated as MeERF72 according to its homolog in Arabidopsis , was screened out. The transcript level of MeERF72 was induced by ethylene, drought, and salt treatments and repressed by abscisic acid, Auxin, gibberellin, salicylic acid, and low and high temperatures. The MeERF72 protein has a conserved APETALA2 domain in its N-terminus and an activated domain of 30 amino acids in its C-terminus, can bind to MeSus1 promoter in vitro and in vivo, and represses the promoter activity of MeSus1 . MeERF72 is a transcription factor that can negatively regulate the expression level of MeSus1 in cassava.

Directly Detecting MeV-Scale Dark Matter Via Solar Reflection

NASA Astrophysics Data System (ADS)

An, Haipeng; Pospelov, Maxim; Pradler, Josef; Ritz, Adam

2018-04-01

If dark matter (DM) particles are lighter than a few MeV /c2 and can scatter off electrons, their interaction within the solar interior results in a considerable hardening of the spectrum of galactic dark matter received on Earth. For a large range of the mass versus cross section parameter space, {me,σe}, the "reflected" component of the DM flux is far more energetic than the end point of the ambient galactic DM energy distribution, making it detectable with existing DM detectors sensitive to an energy deposition of 10 -103 eV . After numerically simulating the small reflected component of the DM flux, we calculate its subsequent signal due to scattering on detector electrons, deriving new constraints on σe in the MeV and sub-MeV range using existing data from the XENON10/100, LUX, PandaX-II, and XENON1T experiments, as well as making projections for future low threshold direct detection experiments.

The SUVR4 Histone Lysine Methyltransferase Binds Ubiquitin and Converts H3K9me1 to H3K9me3 on Transposon Chromatin in Arabidopsis

PubMed Central

Veiseth, Silje V.; Rahman, Mohummad A.; Yap, Kyoko L.; Fischer, Andreas; Egge-Jacobsen, Wolfgang; Reuter, Gunter; Zhou, Ming-Ming; Aalen, Reidunn B.; Thorstensen, Tage

2011-01-01

Chromatin structure and gene expression are regulated by posttranslational modifications (PTMs) on the N-terminal tails of histones. Mono-, di-, or trimethylation of lysine residues by histone lysine methyltransferases (HKMTases) can have activating or repressive functions depending on the position and context of the modified lysine. In Arabidopsis, trimethylation of lysine 9 on histone H3 (H3K9me3) is mainly associated with euchromatin and transcribed genes, although low levels of this mark are also detected at transposons and repeat sequences. Besides the evolutionarily conserved SET domain which is responsible for enzyme activity, most HKMTases also contain additional domains which enable them to respond to other PTMs or cellular signals. Here we show that the N-terminal WIYLD domain of the Arabidopsis SUVR4 HKMTase binds ubiquitin and that the SUVR4 product specificity shifts from di- to trimethylation in the presence of free ubiquitin, enabling conversion of H3K9me1 to H3K9me3 in vitro. Chromatin immunoprecipitation and immunocytological analysis showed that SUVR4 in vivo specifically converts H3K9me1 to H3K9me3 at transposons and pseudogenes and has a locus-specific repressive effect on the expression of such elements. Bisulfite sequencing indicates that this repression involves both DNA methylation–dependent and –independent mechanisms. Transcribed genes with high endogenous levels of H3K4me3, H3K9me3, and H2Bub1, but low H3K9me1, are generally unaffected by SUVR4 activity. Our results imply that SUVR4 is involved in the epigenetic defense mechanism by trimethylating H3K9 to suppress potentially harmful transposon activity. PMID:21423664

Use of beta-methylphenylalanine (beta MeF) residues to probe the nature of the interaction of substance P with its receptor: effects of beta MeF-containing substance P analogs on rabbit iris smooth muscle contraction.

PubMed

Birney, D M; Cole, D C; Crosson, C E; Kahl, B F; Neff, B W; Reid, T W; Ren, K; Walkup, R D

1995-06-23

The effects of substituting (2S,3S)-beta-methylphenylalanine (S-beta MeF) or (2S,3R)-beta-methylphenylalanine (R-beta MeF) for the Phe7 and/or Phe8 residues of the tachykinin substance P (SP, RPKPQQFFGLM-NH2) upon the ability of SP to stimulate contraction of the rabbit iris smooth muscle were investigated. The eight beta MeF-containing SP analogs (four monosubstituted analogs, four disubstituted analogs) 1-8 were synthesized and found to be agonsts of SP in the smooth muscle contraction assay, having EC50 values ranging from 0.15 to 10.0 nM. Three analogs are significantly more active than SP [8R-(beta MeF)SP (4), 7S,8S-(beta MeF)2SP (5), and 7R,8S-(beta MeF)2SP (6)], three analogs are approximately equipotent with SP [7S-(beta MeF)SP (1), 7R-(beta MeF)SP (2), and 7S,8R-(beta MeF)2SP (8)], and two analogs are significantly less active than SP [8S-(beta MeF)SP (3) and 7R,8R-(beta MeF)2SP (7)]. The effects of the beta MeF substitutions upon the activity of SP are not additive and cannot be explained using simple conformational models which focus only on the side chain conformations of the beta MeF residues. It is postulated that the beta MeF residues induce minor distortions in the peptide backbone with resultant consequences upon peptide-receptor binding which are not dictated soley by the side chain conformations. This idea is consistent with 1H-NMR data for the monosubstituted analogs 1-4, which imply that the beta MeF substitutions cause slight distortions in the peptide backbone and that the beta MeF side chains are assuming trans or gauche(-) conformations.

Quality of pharmacy-specific Medical Subject Headings (MeSH) assignment in pharmacy journals indexed in MEDLINE.

PubMed

Minguet, Fernando; Salgado, Teresa M; van den Boogerd, Lucienne; Fernandez-Llimos, Fernando

2015-01-01

The Medical Subject Headings (MeSH) is the National Library of Medicine (NLM) controlled vocabulary for indexing articles. Inaccuracies in the MeSH thesaurus have been reported for several areas including pharmacy. To assess the quality of pharmacy-specific MeSH assignment to articles indexed in pharmacy journals. The 10 journals containing the highest number of articles published in 2012 indexed under the MeSH 'Pharmacists' were identified. All articles published over a 5-year period (2008-2012) in the 10 previously selected journals were retrieved from PubMed. MeSH terms used to index these articles were extracted and pharmacy-specific MeSH terms were identified. The frequency of use of pharmacy-specific MeSH terms was calculated across journals. A total of 6989 articles were retrieved from the 10 pharmacy journals, of which 328 (4.7%) were articles not fully indexed and therefore did not contain any MeSH terms assigned. Among the 6661 articles fully indexed, the mean number of MeSH terms was 10.1 (SD = 4.0), being 1.0 (SD = 1.3) considered as Major MeSH. Both values significantly varied across journals. The mean number of pharmacy-specific MeSH terms per article was 0.9 (SD = 1.2). A total of 3490 (52.4%) of the 6661 articles were indexed in pharmacy journals without a single pharmacy-specific MeSH. Of the total 67193 MeSH terms assigned to articles, on average 10.5% (SD = 13.9) were pharmacy-specific MeSH. A statistically significant different pattern of pharmacy-specific MeSH assignment was identified across journals (Kruskal-Wallis P < 0.001). The quality of assignment of the existing pharmacy-specific MeSH terms to articles indexed in pharmacy journals can be improved to further enhance evidence gathering in pharmacy. Over half of the articles published in the top-10 journals publishing pharmacy literature were indexed without a single pharmacy-specific MeSH. Copyright © 2015 Elsevier Inc. All rights reserved.

40 CFR 267.50 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.50 Section 267.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Contingency Plan and Emergency Procedures § 267.50 Does this subpart apply to me? This subpart...

40 CFR 267.70 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.70 Section 267.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Recordkeeping, Reporting, and Notifying § 267.70 Does this subpart apply to me? This subpart...

5 CFR 839.201 - Do these rules apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 5 Administrative Personnel 2 2011-01-01 2011-01-01 false Do these rules apply to me? 839.201 Section 839.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... COVERAGE CORRECTIONS ACT Eligibility General Provisions § 839.201 Do these rules apply to me? (a) These...

40 CFR 267.70 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.70 Section 267.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Recordkeeping, Reporting, and Notifying § 267.70 Does this subpart apply to me? This subpart...

40 CFR 63.5600 - What other requirements apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false What other requirements apply to me? 63.5600 Section 63.5600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Other Requirements and Information § 63.5600 What other requirements apply to me? (a) Table 10 to this...

33 CFR 165.102 - Security Zone: Walkers Point, Kennebunkport ME.

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Security Zone: Walkers Point, Kennebunkport ME. 165.102 Section 165.102 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: Walkers Point, Kennebunkport ME. (a) Location. The following area is a security zone: From point...

40 CFR 267.50 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.50 Section 267.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Contingency Plan and Emergency Procedures § 267.50 Does this subpart apply to me? This subpart...

40 CFR 267.50 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.50 Section 267.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Contingency Plan and Emergency Procedures § 267.50 Does this subpart apply to me? This subpart...

5 CFR 839.201 - Do these rules apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Do these rules apply to me? 839.201 Section 839.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... COVERAGE CORRECTIONS ACT Eligibility General Provisions § 839.201 Do these rules apply to me? (a) These...

40 CFR 267.1100 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.1100 Section 267.1100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1100 Does this subpart apply to me? This subpart applies to you...

40 CFR 267.70 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.70 Section 267.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Recordkeeping, Reporting, and Notifying § 267.70 Does this subpart apply to me? This subpart...

40 CFR 267.50 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.50 Section 267.50 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Contingency Plan and Emergency Procedures § 267.50 Does this subpart apply to me? This subpart...

33 CFR 165.102 - Security Zone: Walkers Point, Kennebunkport ME.

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Security Zone: Walkers Point, Kennebunkport ME. 165.102 Section 165.102 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: Walkers Point, Kennebunkport ME. (a) Location. The following area is a security zone: From point...

40 CFR 267.1100 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.1100 Section 267.1100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1100 Does this subpart apply to me? This subpart applies to you...

33 CFR 165.102 - Security Zone: Walkers Point, Kennebunkport ME.

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Security Zone: Walkers Point, Kennebunkport ME. 165.102 Section 165.102 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: Walkers Point, Kennebunkport ME. (a) Location. The following area is a security zone: From point...

40 CFR 63.215 - What General Provisions apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 10 2013-07-01 2013-07-01 false What General Provisions apply to me? 63.215 Section 63.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Other Requirements and Information § 63.215 What General Provisions apply to me? (a) All the provisions...

40 CFR 63.215 - What General Provisions apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 10 2012-07-01 2012-07-01 false What General Provisions apply to me? 63.215 Section 63.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR... Other Requirements and Information § 63.215 What General Provisions apply to me? (a) All the provisions...

33 CFR 165.102 - Security Zone: Walkers Point, Kennebunkport ME.

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Security Zone: Walkers Point, Kennebunkport ME. 165.102 Section 165.102 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND... Zone: Walkers Point, Kennebunkport ME. (a) Location. The following area is a security zone: From point...

40 CFR 267.1100 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.1100 Section 267.1100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1100 Does this subpart apply to me? This subpart applies to you...

40 CFR 267.70 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.70 Section 267.70 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Recordkeeping, Reporting, and Notifying § 267.70 Does this subpart apply to me? This subpart...

5 CFR 839.201 - Do these rules apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 5 Administrative Personnel 2 2012-01-01 2012-01-01 false Do these rules apply to me? 839.201 Section 839.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... COVERAGE CORRECTIONS ACT Eligibility General Provisions § 839.201 Do these rules apply to me? (a) These...

40 CFR 267.1100 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.1100 Section 267.1100 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID... STANDARDIZED PERMIT Containment buildings § 267.1100 Does this subpart apply to me? This subpart applies to you...

5 CFR 839.201 - Do these rules apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 5 Administrative Personnel 2 2013-01-01 2013-01-01 false Do these rules apply to me? 839.201 Section 839.201 Administrative Personnel OFFICE OF PERSONNEL MANAGEMENT (CONTINUED) CIVIL SERVICE... COVERAGE CORRECTIONS ACT Eligibility General Provisions § 839.201 Do these rules apply to me? (a) These...

Cluster analysis of the biochemical composition in 53 Sichuan EGCG3"Me tea resources

NASA Astrophysics Data System (ADS)

Li, J. H.; Chen, S. X.; Zhu, M. Z.; Meng, X. L.

2017-09-01

The EGCG3"Me contents in the young tea leaves of 102 tea resources in sichuan were analyzed accurately using HPLC-DAD. The results revealed that there was a wide variation in EGCG3"Me levels among different tea resources. The EGCG3"Me content in different tea resources was in a range from 0 to 11.04 mg/g, mean was 2.33 mg/g.53 tea resources contained EGCG3"Me, accounting for 51.96% of the total number of resources survey. Shucha5, Jinguanyin, Chengxi11, Fenghuang-dancong, Chongpi 71-1 were found to contain higher EGCG3"Me content (>10mg/g).Cluster analysis showed that: 53 Sichuan EGCG3"Me tea resources were divided into six groups and the difference was obvious between their biochemical composition; tea resources rich in EGCG3"Me were mainly distributed in Sichuan, Chongqing and Fujian Province, mostly were shrub and mid-leaf, mainly existed in tea resources which were suitable to make green tea, oolong tea. The morphological and biochemical distribution provided a good theoretical basis for selecting and utilizing higher EGCG3"Me resources.

Rapid determination of the energy magnitude Me

NASA Astrophysics Data System (ADS)

di Giacomo, D.; Parolai, S.; Bormann, P.; Grosser, H.; Saul, J.; Wang, R.; Zschau, J.

2009-12-01

The magnitude of an earthquake is one of the most used parameters to evaluate the earthquake’s damage potential. Among the non-saturating magnitude scales, the energy magnitude Me is related to a well defined physical parameter of the seismic source, that is the radiated seismic energy Es (e.g. Bormann et al., 2002): Me = 2/3(log10 Es - 4.4). Me is more suitable than the moment magnitude Mw in describing an earthquake's shaking potential (Choy and Kirby, 2004). Indeed, Me is calculated over a wide frequency range of the source spectrum and represents a better measure of the shaking potential, whereas Mw is related to the low-frequency asymptote of the source spectrum and is a good measure of the fault size and hence of the static (tectonic) effect of an earthquake. We analyse teleseismic broadband P-waves signals in the distance range 20°-98° to calculate Es. To correct the frequency-dependent energy loss experienced by the P-waves during the propagation path, we use pre-calculated spectral amplitude decay functions for different frequencies obtained from numerical simulations of Green’s functions (Wang, 1999) given the reference Earth model AK135Q (Kennett et al., 1995; Montagner and Kennett, 1996). By means of these functions the correction for the various propagation effects of the recorded P-wave velocity spectra is performed in a rapid and robust way, and the calculation of ES, and hence of Me, can be computed at the single station. We show that our procedure is suitable for implementation in rapid response systems since it could provide stable Me determinations within 10-15 minutes after the earthquake’s origin time, even in case of great earthquakes. We tested our procedure for a large dataset composed by about 770 earthquakes globally distributed in the Mw range 5.5-9.3 recorded at the broadband stations managed by the IRIS, GEOFON, and GEOSCOPE global networks, as well as other regional seismic networks. Me and Mw express two different aspects of

Characterisation of cell functions and receptors in Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME).

PubMed

Hardcastle, Sharni Lee; Brenu, Ekua Weba; Johnston, Samantha; Nguyen, Thao; Huth, Teilah; Wong, Naomi; Ramos, Sandra; Staines, Donald; Marshall-Gradisnik, Sonya

2015-06-02

Abnormal immune function is often an underlying component of illness pathophysiology and symptom presentation. Functional and phenotypic immune-related alterations may play a role in the obscure pathomechanism of Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME). The objective of this study was to investigate the functional ability of innate and adaptive immune cells in moderate and severe CFS/ME patients. The 1994 Fukuda criteria for CFS/ME were used to define CFS/ME patients. CFS/ME participants were grouped based on illness severity with 15 moderately affected (moderate) and 12 severely affected (severe) CFS/ME patients who were age and sex matched with 18 healthy controls. Flow cytometric protocols were used for immunological analysis of dendritic cells, monocytes and neutrophil function as well as measures of lytic proteins and T, natural killer (NK) and B cell receptors. CFS/ME patients exhibited alterations in NK receptors and adhesion markers and receptors on CD4(+)T and CD8(+)T cells. Moderate CFS/ME patients had increased CD8(+) CD45RA effector memory T cells, SLAM expression on NK cells, KIR2DL5(+) on CD4(+)T cells and BTLA4(+) on CD4(+)T central memory cells. Moderate CFS/ME patients also had reduced CD8(+)T central memory LFA-1, total CD8(+)T KLRG1, naïve CD4(+)T KLRG1 and CD56(dim)CD16(-) NK cell CD2(+) and CD18(+)CD2(+). Severe CFS/ME patients had increased CD18(+)CD11c(-) in the CD56(dim)CD16(-) NK cell phenotype and reduced NKp46 in CD56(bright)CD16(dim) NK cells. This research accentuated the presence of immunological abnormalities in CFS/ME and highlighted the importance of assessing functional parameters of both innate and adaptive immune systems in the illness.

MeRHIC - staging approach to eRHIC

DOE Office of Scientific and Technical Information (OSTI.GOV)

Ptitsyn,V.; Beebe-Wang, J.; Ben-Zvi, I.

Design of a medium energy electron-ion collider (MeRHIC) is under development at the Collider-Accelerator Department at BNL. The design envisions construction of a 4 GeV electron accelerator in a local area inside and near the RHIC tunnel. Electrons will be produced by a polarized electron source and accelerated in energy recovery linacs. Collisions of the electron beam with 100 GeV/u heavy ions or with 250 GeV polarized protons will be arranged in the existing IP2 interaction region of RHIC. The luminosity of electron-proton collisions at the 10{sup 32} cm{sup -2}s{sup -1} level will be achieved with 50 mA CW electronmore » current and presently available proton beam parameters. Efficient proton beam cooling at collision energy may bring the luminosity to 10{sup 33} cm{sup -2}s{sup -1}. An important feature of MeRHIC is that it serves as a first stage of eRHIC, a future electron-ion collider at BNL with both higher luminosity and energy reach. The majority of MeRHIC accelerator components will be used in eRHIC.« less

CDDO-Me reveals USP7 as a novel target in ovarian cancer cells.

PubMed

Qin, Dongjun; Wang, Weiwei; Lei, Hu; Luo, Hao; Cai, Haiyan; Tang, Caixia; Wu, Yunzhao; Wang, Yingying; Jin, Jin; Xiao, Weilie; Wang, Tongdan; Ma, Chunmin; Xu, Hanzhang; Zhang, Jinfu; Gao, Fenghou; Wu, Ying-Li

2016-11-22

Deubiquitinating enzyme USP7 has been involved in the pathogenesis and progression of several cancers. Targeting USP7 is becoming an attractive strategy for cancer therapy. In this study, we identified synthetic triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid (CDDO-Me) as a novel inhibitor of USP7 but not of other cysteine proteases such as cathepsin B and cathepsin D. CDDO-Me inhibits USP7 activity via a mechanism that is independent of the presence of α, β-unsaturated ketones. Molecular docking studies showed that CDDO-Me fits well in the ubiquitin carboxyl terminus-binding pocket on USP7. Given that CDDO-Me is known to be effective against ovarian cancer cells, we speculated that CDDO-Me may target USP7 in ovarian cancer cells. We demonstrated that ovarian cancer cells have higher USP7 expression than their normal counterparts. Knockdown of USP7 inhibits the proliferation of ovarian cancer cells both in vitro and in vivo. Using the cellular thermal shift assay and the drug affinity responsive target stability assay, we further demonstrated that CDDO-Me directly binds to USP7 in cells, which leads to the decrease of its substrates such as MDM2, MDMX and UHRF1. CDDO-Me suppresses ovarian cancer tumor growth in an xenograft model. In conclusion, we demonstrate that USP7 is a novel target of ovarian cancer cells; targeting USP7 may contribute to the anti-cancer effect of CDDO-Me. The development of novel USP7 selective compounds based on the CDDO-Me-scaffold warrants further investigation.

CDDO-Me reveals USP7 as a novel target in ovarian cancer cells

PubMed Central

Cai, Haiyan; Tang, Caixia; Wu, Yunzhao; Wang, Yingying; Jin, Jin; Xiao, Weilie; Wang, Tongdan; Ma, Chunmin; Xu, Hanzhang; Zhang, Jinfu; Gao, Fenghou; Wu, Ying-Li

2016-01-01

Deubiquitinating enzyme USP7 has been involved in the pathogenesis and progression of several cancers. Targeting USP7 is becoming an attractive strategy for cancer therapy. In this study, we identified synthetic triterpenoid C-28 methyl ester of 2-cyano-3, 12-dioxoolen-1, 9-dien-28-oic acid (CDDO-Me) as a novel inhibitor of USP7 but not of other cysteine proteases such as cathepsin B and cathepsin D. CDDO-Me inhibits USP7 activity via a mechanism that is independent of the presence of α, β-unsaturated ketones. Molecular docking studies showed that CDDO-Me fits well in the ubiquitin carboxyl terminus-binding pocket on USP7. Given that CDDO-Me is known to be effective against ovarian cancer cells, we speculated that CDDO-Me may target USP7 in ovarian cancer cells. We demonstrated that ovarian cancer cells have higher USP7 expression than their normal counterparts. Knockdown of USP7 inhibits the proliferation of ovarian cancer cells both in vitro and in vivo. Using the cellular thermal shift assay and the drug affinity responsive target stability assay, we further demonstrated that CDDO-Me directly binds to USP7 in cells, which leads to the decrease of its substrates such as MDM2, MDMX and UHRF1. CDDO-Me suppresses ovarian cancer tumor growth in an xenograft model. In conclusion, we demonstrate that USP7 is a novel target of ovarian cancer cells; targeting USP7 may contribute to the anti-cancer effect of CDDO-Me. The development of novel USP7 selective compounds based on the CDDO-Me-scaffold warrants further investigation. PMID:27780924

The School Child with ME.

ERIC Educational Resources Information Center

Colby, Jane

1994-01-01

This article describes the incidence, symptoms, management, and other aspects of myalgic encephalomyelitis (ME) in relation to children in school. The disease is probably caused by an enterovirus and is characterized by extreme fatigue, muscle pain, an inability to concentrate, impaired speech, and sensory disturbances. Suggestions for managing…

23 CFR 636.102 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 23 Highways 1 2012-04-01 2012-04-01 false Does this part apply to me? 636.102 Section 636.102 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.102 Does this part apply to me? (a) This part uses a plain...

29 CFR 1471.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Does this part apply to me? 1471.105 Section 1471.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.105 Does this part apply to me? Portions of this part...

40 CFR 63.5600 - What other requirements apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true What other requirements apply to me? 63.5600 Section 63.5600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Information § 63.5600 What other requirements apply to me? (a) Table 10 to this subpart shows which provisions...

29 CFR 1471.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Does this part apply to me? 1471.105 Section 1471.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.105 Does this part apply to me? Portions of this part...

22 CFR 133.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 1 2013-04-01 2013-04-01 false Does this part apply to me? 133.105 Section 133.105 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 133.105 Does this part apply to me? (a) Portions of...

28 CFR 83.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 28 Judicial Administration 2 2011-07-01 2011-07-01 false Does this part apply to me? 83.105 Section 83.105 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Purpose and Coverage § 83.105 Does this part apply to me? (a) Portions of...

33 CFR 128.100 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 2 2013-07-01 2013-07-01 false Does this part apply to me? 128.100 Section 128.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... me? This part applies to all passenger terminals in the United States or its territories when being...

13 CFR 147.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 13 Business Credit and Assistance 1 2012-01-01 2012-01-01 false Does this part apply to me? 147.105 Section 147.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Purpose and Coverage § 147.105 Does this part apply to me...

13 CFR 147.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 13 Business Credit and Assistance 1 2013-01-01 2013-01-01 false Does this part apply to me? 147.105 Section 147.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Purpose and Coverage § 147.105 Does this part apply to me...

40 CFR 267.10 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.10 Section 267.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT General Facility Standards § 267.10 Does this subpart apply to me? This subpart applies to you if...

40 CFR 267.30 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.30 Section 267.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Preparedness and Prevention § 267.30 Does this subpart apply to me? This subpart applies to you if...

28 CFR 83.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Does this part apply to me? 83.105 Section 83.105 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Purpose and Coverage § 83.105 Does this part apply to me? (a) Portions of...

33 CFR 128.100 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 2 2011-07-01 2011-07-01 false Does this part apply to me? 128.100 Section 128.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... me? This part applies to all passenger terminals in the United States or its territories when being...

33 CFR 128.100 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 2 2012-07-01 2012-07-01 false Does this part apply to me? 128.100 Section 128.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... me? This part applies to all passenger terminals in the United States or its territories when being...

13 CFR 147.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 13 Business Credit and Assistance 1 2011-01-01 2011-01-01 false Does this part apply to me? 147.105 Section 147.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Purpose and Coverage § 147.105 Does this part apply to me...

22 CFR 1509.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Does this part apply to me? 1509.105 Section 1509.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1509.105 Does this part apply to me? (a) Portions of...

29 CFR 1471.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Does this part apply to me? 1471.105 Section 1471.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.105 Does this part apply to me? Portions of this part...

40 CFR 49.168 - Does this program apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 1 2013-07-01 2013-07-01 false Does this program apply to me? 49.168 Section 49.168 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... program apply to me? (a) In a nonattainment area for a pollutant in Indian country, the requirements of...

40 CFR 267.170 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.170 Section 267.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Use and Management of Containers § 267.170 Does this subpart apply to me? This subpart applies to...

40 CFR 267.30 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.30 Section 267.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Preparedness and Prevention § 267.30 Does this subpart apply to me? This subpart applies to you if...

22 CFR 210.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Does this part apply to me? 210.105 Section 210.105 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 210.105 Does this part apply to me? (a) Portions of...

22 CFR 1008.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Does this part apply to me? 1008.105 Section 1008.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1008.105 Does this part apply to me? (a) Portions of...

28 CFR 83.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 28 Judicial Administration 2 2013-07-01 2013-07-01 false Does this part apply to me? 83.105 Section 83.105 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Purpose and Coverage § 83.105 Does this part apply to me? (a) Portions of...

2 CFR 1880.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1880.20 Section 1880.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 1880.20 Does this part apply to me...

2 CFR 1880.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1880.20 Section 1880.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 1880.20 Does this part apply to me...

40 CFR 267.30 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.30 Section 267.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Preparedness and Prevention § 267.30 Does this subpart apply to me? This subpart applies to you if...

22 CFR 133.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Does this part apply to me? 133.105 Section 133.105 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 133.105 Does this part apply to me? (a) Portions of...

23 CFR 636.102 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 23 Highways 1 2013-04-01 2013-04-01 false Does this part apply to me? 636.102 Section 636.102 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.102 Does this part apply to me? (a) This part uses a plain...

40 CFR 267.10 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.10 Section 267.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT General Facility Standards § 267.10 Does this subpart apply to me? This subpart applies to you if...

40 CFR 63.5600 - What other requirements apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true What other requirements apply to me? 63.5600 Section 63.5600 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Requirements and Information § 63.5600 What other requirements apply to me? (a) Table 10 to this subpart shows...

13 CFR 147.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 13 Business Credit and Assistance 1 2010-01-01 2010-01-01 false Does this part apply to me? 147.105 Section 147.105 Business Credit and Assistance SMALL BUSINESS ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (NONPROCUREMENT) Purpose and Coverage § 147.105 Does this part apply to me...

22 CFR 133.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 22 Foreign Relations 1 2012-04-01 2012-04-01 false Does this part apply to me? 133.105 Section 133.105 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 133.105 Does this part apply to me? (a) Portions of...

40 CFR 267.10 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.10 Section 267.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT General Facility Standards § 267.10 Does this subpart apply to me? This subpart applies to you if...

28 CFR 83.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 28 Judicial Administration 2 2012-07-01 2012-07-01 false Does this part apply to me? 83.105 Section 83.105 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) GOVERNMENT-WIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (GRANTS) Purpose and Coverage § 83.105 Does this part apply to me? (a) Portions of...

20 CFR 439.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Does this part apply to me? 439.105 Section 439.105 Employees' Benefits SOCIAL SECURITY ADMINISTRATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 439.105 Does this part apply to me? (a) Portions of...

2 CFR 1880.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 1880.20 Section 1880.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 1880.20 Does this part apply to me...

22 CFR 1509.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Does this part apply to me? 1509.105 Section 1509.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1509.105 Does this part apply to me? (a) Portions of...

22 CFR 210.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Does this part apply to me? 210.105 Section 210.105 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 210.105 Does this part apply to me? (a) Portions of...

40 CFR 267.170 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.170 Section 267.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Use and Management of Containers § 267.170 Does this subpart apply to me? This subpart applies to...

33 CFR 128.100 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 2 2010-07-01 2010-07-01 false Does this part apply to me? 128.100 Section 128.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY... me? This part applies to all passenger terminals in the United States or its territories when being...

22 CFR 1509.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Does this part apply to me? 1509.105 Section 1509.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1509.105 Does this part apply to me? (a) Portions of...

40 CFR 267.30 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.30 Section 267.30 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Preparedness and Prevention § 267.30 Does this subpart apply to me? This subpart applies to you if...

40 CFR 63.2231 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 12 2011-07-01 2009-07-01 true Does this subpart apply to me? 63.2231 Section 63.2231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS....2231 Does this subpart apply to me? This subpart applies to you if you meet the criteria in paragraphs...

40 CFR 267.170 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.170 Section 267.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Use and Management of Containers § 267.170 Does this subpart apply to me? This subpart applies to...

40 CFR 49.168 - Does this program apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 1 2012-07-01 2012-07-01 false Does this program apply to me? 49.168 Section 49.168 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... program apply to me? (a) In a nonattainment area for a pollutant in Indian country, the requirements of...

22 CFR 133.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Does this part apply to me? 133.105 Section 133.105 Foreign Relations DEPARTMENT OF STATE MISCELLANEOUS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 133.105 Does this part apply to me? (a) Portions of...

40 CFR 267.10 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.10 Section 267.10 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT General Facility Standards § 267.10 Does this subpart apply to me? This subpart applies to you if...

40 CFR 267.170 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.170 Section 267.170 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Use and Management of Containers § 267.170 Does this subpart apply to me? This subpart applies to...

23 CFR 636.102 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 23 Highways 1 2010-04-01 2010-04-01 false Does this part apply to me? 636.102 Section 636.102 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.102 Does this part apply to me? (a) This part uses a plain...

29 CFR 1471.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Does this part apply to me? 1471.105 Section 1471.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1471.105 Does this part apply to me? Portions of this part...

22 CFR 1008.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Does this part apply to me? 1008.105 Section 1008.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1008.105 Does this part apply to me? (a) Portions of...

22 CFR 1008.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Does this part apply to me? 1008.105 Section 1008.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1008.105 Does this part apply to me? (a) Portions of...

40 CFR 63.5090 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Does this subpart apply to me? 63.5090 Section 63.5090 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Does this subpart apply to me? (a) The provisions of this subpart apply to each facility that is a...

40 CFR 49.168 - Does this program apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 1 2011-07-01 2011-07-01 false Does this program apply to me? 49.168 Section 49.168 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY GRANTS AND OTHER FEDERAL... program apply to me? (a) In a nonattainment area for a pollutant in Indian country, the requirements of...

23 CFR 636.102 - Does this part apply to me?

Code of Federal Regulations, 2014 CFR

2014-04-01

... 23 Highways 1 2014-04-01 2014-04-01 false Does this part apply to me? 636.102 Section 636.102 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.102 Does this part apply to me? (a) This part uses a plain...

23 CFR 636.102 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 23 Highways 1 2011-04-01 2011-04-01 false Does this part apply to me? 636.102 Section 636.102 Highways FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS DESIGN-BUILD CONTRACTING General § 636.102 Does this part apply to me? (a) This part uses a plain...

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma.

PubMed

Maia, Lucas de Lima; Peterle, Gabriela Tonini; Dos Santos, Marcelo; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; de Oliveira, Mayara Mota; Dos Santos, Joaquim Gasparini; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; de Assis, Aricia Leone Evangelista Monteiro; Archanjo, Anderson Barros; Mercante, Ana Maria Da Cunha; Lopez, Rossana Veronica Mendoza; Nunes, Fábio Daumas; de Carvalho, Marcos Brasilino; Tajara, Eloiza Helena; Louro, Iúri Drumond; Álvares-da-Silva, Adriana Madeira

2018-01-01

Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets.

JMJD1A, H3K9me1, H3K9me2 and ADM expression as prognostic markers in oral and oropharyngeal squamous cell carcinoma

PubMed Central

Peterle, Gabriela Tonini; dos Santos, Marcelo; Trivilin, Leonardo Oliveira; Mendes, Suzanny Oliveira; de Oliveira, Mayara Mota; dos Santos, Joaquim Gasparini; Stur, Elaine; Agostini, Lidiane Pignaton; Couto, Cinthia Vidal Monteiro da Silva; Dalbó, Juliana; de Assis, Aricia Leone Evangelista Monteiro; Archanjo, Anderson Barros; Mercante, Ana Maria Da Cunha; Lopez, Rossana Veronica Mendoza; Nunes, Fábio Daumas; de Carvalho, Marcos Brasilino; Tajara, Eloiza Helena; Louro, Iúri Drumond; Álvares-da-Silva, Adriana Madeira

2018-01-01

Aims Jumonji Domain-Containing 1A (JMJD1A) protein promotes demethylation of histones, especially at lysin-9 of di-methylated histone H3 (H3K9me2) or mono-methylated (H3K9me1). Increased levels of H3 histone methylation at lysin-9 (H3K9) is related to tumor suppressor gene silencing. JMJD1A gene target Adrenomeduline (ADM) has shown to promote cell growth and tumorigenesis. JMJD1A and ADM expression, as well as H3K9 methylation level have been related with development risk and prognosis of several tumor types. Methods and results We aimed to evaluate JMJD1A, ADM, H3K9me1 and H3K9me2expression in paraffin-embedded tissue microarrays from 84 oral and oropharyngeal squamous cell carcinoma samples through immunohistochemistry analysis. Our results showed that nuclear JMJD1A expression was related to lymph node metastasis risk. In addition, JMJD1A cytoplasmic expression was an independent risk marker for advanced tumor stages. H3K9me1 cytoplasmic expression was associated with reduced disease-specific death risk. Furthermore, high H3K9me2 nuclear expression was associated with worse specific-disease and disease-free survival. Finally, high ADM cytoplasmic expression was an independent marker of lymph node metastasis risk. Conclusion JMJD1A, H3K9me1/2 and ADM expression may be predictor markers of progression and prognosis in oral and oropharynx cancer patients, as well as putative therapeutic targets. PMID:29590186

41 CFR 301-10.116 - What must I do with compensation an airline gives me if it denies me a seat on a plane?

Code of Federal Regulations, 2010 CFR

2010-07-01

... compensation an airline gives me if it denies me a seat on a plane? 301-10.116 Section 301-10.116 Public... plane? If you are performing official travel and a carrier denies you a confirmed reserved seat on a plane, you must give your agency any payment you receive for liquidated damages. You must ensure the...

'What is it like to have ME?': the discursive construction of ME in computer-mediated communication and face-to-face interaction.

PubMed

Guise, Jennifer; Widdicombe, Sue; McKinlay, Andy

2007-01-01

ME (Myalgic Encephalomyelitis) or CFS (chronic fatigue syndrome) is a debilitating illness for which no cause or medical tests have been identified. Debates over its nature have generated interest from qualitative researchers. However, participants are difficult to recruit because of the nature of their condition. Therefore, this study explores the utility of the internet as a means of eliciting accounts. We analyse data from focus groups and the internet in order to ascertain the extent to which previous research findings apply to the internet domain. Interviews were conducted among 49 members of internet groups (38 chatline, 11 personal) and 7 members of two face-to-face support groups. Discourse analysis of descriptions and accounts of ME or CFS revealed similar devices and interactional concerns in both internet and face-to-face communication. Participants constructed their condition as serious, enigmatic and not psychological. These functioned to deflect problematic assumptions about ME or CFS and to manage their accountability for the illness and its effects.

Modelling soil salinity in Oued El Abid watershed, Morocco

NASA Astrophysics Data System (ADS)

Mouatassime Sabri, El; Boukdir, Ahmed; Karaoui, Ismail; Arioua, Abdelkrim; Messlouhi, Rachid; El Amrani Idrissi, Abdelkhalek

2018-05-01

Soil salinisation is a phenomenon considered to be a real threat to natural resources in semi-arid climates. The phenomenon is controlled by soil (texture, depth, slope etc.), anthropogenic factors (drainage system, irrigation, crops types, etc.), and climate factors. This study was conducted in the watershed of Oued El Abid in the region of Beni Mellal-Khenifra, aimed at localising saline soil using remote sensing and a regression model. The spectral indices were extracted from Landsat imagery (30 m resolution). A linear correlation of electrical conductivity, which was calculated based on soil samples (ECs), and the values extracted based on spectral bands showed a high accuracy with an R2 (Root square) of 0.80. This study proposes a new spectral salinity index using Landsat bands B1 and B4. This hydro-chemical and statistical study, based on a yearlong survey, showed a moderate amount of salinity, which threatens dam water quality. The results present an improved ability to use remote sensing and regression model integration to detect soil salinity with high accuracy and low cost, and permit intervention at an early stage of salinisation.

2 CFR 902.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 902.20 Section 902.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 902.20 Does this part apply to me...

2 CFR 902.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 902.20 Section 902.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 902.20 Does this part apply to me...

2 CFR 901.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 901.20 Section 901.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved NONPROCUREMENT DEBARMENT AND SUSPENSION § 901.20 Does this part apply to me? This part and...

49 CFR 32.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 49 Transportation 1 2011-10-01 2011-10-01 false Does this part apply to me? 32.105 Section 32.105 Transportation Office of the Secretary of Transportation GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 32.105 Does this part apply to me? (a) Portions of this part...

2 CFR 3000.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3000.20 Section 3000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOMELAND SECURITY NONPROCUREMENT DEBARMENT AND SUSPENSION § 3000.20 Does this part apply to me? This part...

2 CFR 2520.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2520.20 Section 2520.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL SCIENCE FOUNDATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2520.20 Does this part apply to me? This part and...

2 CFR 2200.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2200.20 Section 2200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONPROCUREMENT DEBARMENT AND SUSPENSION § 2200.20 Does this part apply to me...

2 CFR 3254.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3254.20 Section 3254.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT FOR THE ARTS NONPROCUREMENT DEBARMENT AND SUSPENSION § 3254.20 Does this part apply to me? This part...

2 CFR 780.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 780.20 Section 780.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements AGENCY FOR INTERNATIONAL DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 780.20 Does this part apply to me? This part...

2 CFR 376.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 376.20 Section 376.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH AND HUMAN SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 376.20 Does this part apply to me? This...

2 CFR 1200.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1200.20 Section 1200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF TRANSPORTATION NONPROCUREMENT SUSPENSION AND DEBARMENT § 1200.20 Does this part apply to me? This part and...

2 CFR 3254.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 3254.20 Section 3254.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT FOR THE ARTS NONPROCUREMENT DEBARMENT AND SUSPENSION § 3254.20 Does this part apply to me? This part...

45 CFR 1173.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Does this part apply to me? 1173.105 Section 1173.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1173.105 Does this part apply to me? (a) Portions of...

2 CFR 2245.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2245.20 Section 2245.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR... this part apply to me? This part and, through this part, pertinent portions of the OMB guidance in...

2 CFR 782.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 782.20 Section 782.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements AGENCY FOR... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

40 CFR 63.5090 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Does this subpart apply to me? 63.5090 Section 63.5090 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Covers § 63.5090 Does this subpart apply to me? (a) The provisions of this subpart apply to each facility...

2 CFR 2520.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2520.20 Section 2520.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL SCIENCE FOUNDATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2520.20 Does this part apply to me? This part and...

22 CFR 1006.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Does this part apply to me? 1006.105 Section 1006.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1006.105 Does this part apply to me? Portions of this part (see table at § 1006.25(b...

40 CFR 267.110 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.110 Section 267.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Closure § 267.110 Does this subpart apply to me? This subpart applies to you if you own or operate...

2 CFR 2424.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 2424.20 Section 2424.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 2424.20 Does this part apply to me...

2 CFR 801.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 801.20 Section 801.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF VETERANS AFFAIRS NONPROCUREMENT DEBARMENT AND SUSPENSION § 801.20 Does this part apply to me? This part and...

2 CFR 3373.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3373.20 Section 3373.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT... part apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts...

2 CFR 3185.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 3185.20 Section 3185.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements INSTITUTE OF MUSEUM AND LIBRARY SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3185.20 Does this part apply to me...

22 CFR 1508.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Does this part apply to me? 1508.105 Section 1508.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.105 Does this part apply to me? Portions of this part (see table at § 1508.25(b...

40 CFR 1048.1 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 33 2011-07-01 2011-07-01 false Does this part apply to me? 1048.1 Section 1048.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... § 1048.1 Does this part apply to me? (a) The regulations in this part 1048 apply for all new, spark...

2 CFR 1532.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 1532.20 Section 1532.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL PROTECTION AGENCY NONPROCUREMENT DEBARMENT AND SUSPENSION § 1532.20 Does this part apply to me? This part and...

2 CFR 2424.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2424.20 Section 2424.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 2424.20 Does this part apply to me...

40 CFR 63.2981 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Does this subpart apply to me? 63.2981 Section 63.2981 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Subpart Covers § 63.2981 Does this subpart apply to me? You must comply with this subpart if you meet the...

2 CFR 1532.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1532.20 Section 1532.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL PROTECTION AGENCY NONPROCUREMENT DEBARMENT AND SUSPENSION § 1532.20 Does this part apply to me? This part and...

2 CFR 3369.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3369.20 Section 3369.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT FOR THE HUMANITIES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3369.20 Does this part apply to me? This...

2 CFR 2200.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 2200.20 Section 2200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONPROCUREMENT DEBARMENT AND SUSPENSION § 2200.20 Does this part apply to me...

2 CFR 2339.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2339.20 Section 2339.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 2339.20 Does this part apply to me...

22 CFR 1006.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Does this part apply to me? 1006.105 Section 1006.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1006.105 Does this part apply to me? Portions of this part (see table at § 1006.25(b...

2 CFR 3185.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3185.20 Section 3185.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements INSTITUTE OF MUSEUM AND LIBRARY SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3185.20 Does this part apply to me...

40 CFR 267.190 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.190 Section 267.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Tank Systems § 267.190 Does this subpart apply to me? This subpart applies to you if you own or...

34 CFR 84.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Does this part apply to me? 84.105 Section 84.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 84.105 Does this part apply to me? (a) Portions of...

40 CFR 63.215 - What General Provisions apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 9 2011-07-01 2011-07-01 false What General Provisions apply to me? 63.215 Section 63.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... and Information § 63.215 What General Provisions apply to me? (a) All the provisions in 40 CFR part 61...

2 CFR 417.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 417.20 Section 417.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF AGRICULTURE NONPROCUREMENT DEBARMENT AND SUSPENSION § 417.20 Does this part apply to me? Through this part...

40 CFR 267.110 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.110 Section 267.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Closure § 267.110 Does this subpart apply to me? This subpart applies to you if you own or operate...

2 CFR 3373.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3373.20 Section 3373.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT... part apply to me? This part and, through this part, pertinent portions of the OMB guidance in Subparts...

2 CFR 417.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 417.20 Section 417.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF AGRICULTURE NONPROCUREMENT DEBARMENT AND SUSPENSION § 417.20 Does this part apply to me? Through this part...

2 CFR 2424.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2424.20 Section 2424.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 2424.20 Does this part apply to me...

2 CFR 2600.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 2600.20 Section 2600.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ARCHIVES... me? This part and, through this part, pertinent portions of the OMB guidance in subparts A through I...

2 CFR 2424.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2424.20 Section 2424.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOUSING AND URBAN DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 2424.20 Does this part apply to me...

2 CFR 1326.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 1326.20 Section 1326.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF COMMERCE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1326.20 Does this part apply to me? This part and...

40 CFR 63.3290 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Does this subpart apply to me? 63.3290 Section 63.3290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Covers § 63.3290 Does this subpart apply to me? The provisions of this subpart apply to each new and...

2 CFR 1125.30 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1125.30 Section 1125.30 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF DEFENSE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1125.30 Does this part apply to me? This part and...

2 CFR 2000.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2000.20 Section 2000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements UNITED STATES... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

40 CFR 1068.1 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Does this part apply to me? 1068.1 Section 1068.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... § 1068.1 Does this part apply to me? (a) The provisions of this part apply to everyone with respect to...

14 CFR 1267.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 14 Aeronautics and Space 5 2013-01-01 2013-01-01 false Does this part apply to me? 1267.105 Section 1267.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

40 CFR 267.190 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Does this subpart apply to me? 267.190 Section 267.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Tank Systems § 267.190 Does this subpart apply to me? This subpart applies to you if you own or...

2 CFR 901.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 901.20 Section 901.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved NONPROCUREMENT DEBARMENT AND SUSPENSION § 901.20 Does this part apply to me? This part and...

14 CFR 1267.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 14 Aeronautics and Space 5 2012-01-01 2012-01-01 false Does this part apply to me? 1267.105 Section 1267.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

2 CFR 2700.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2700.20 Section 2700.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SMALL BUSINESS ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2700.20 Does this part apply to me? This part and...

2 CFR 3000.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 3000.20 Section 3000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOMELAND SECURITY NONPROCUREMENT DEBARMENT AND SUSPENSION § 3000.20 Does this part apply to me? This part...

40 CFR 267.110 - Does this subpart apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Does this subpart apply to me? 267.110 Section 267.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Closure § 267.110 Does this subpart apply to me? This subpart applies to you if you own or operate...

2 CFR 1125.30 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1125.30 Section 1125.30 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF DEFENSE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1125.30 Does this part apply to me? This part and...

2 CFR 1536.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1536.20 Section 1536.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A through...

2 CFR 3001.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3001.20 Section 3001.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF... apply to me? This part and, through this part, pertinent portions of the OMB guidance in Subparts A...

14 CFR 1267.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 14 Aeronautics and Space 5 2011-01-01 2010-01-01 true Does this part apply to me? 1267.105 Section 1267.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

40 CFR 63.215 - What General Provisions apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 9 2010-07-01 2010-07-01 false What General Provisions apply to me? 63.215 Section 63.215 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... and Information § 63.215 What General Provisions apply to me? (a) All the provisions in 40 CFR part 61...

2 CFR 1200.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1200.20 Section 1200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF TRANSPORTATION NONPROCUREMENT SUSPENSION AND DEBARMENT § 1200.20 Does this part apply to me? This part and...

2 CFR 2000.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2000.20 Section 2000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements UNITED STATES... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

2 CFR 901.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 901.20 Section 901.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved NONPROCUREMENT DEBARMENT AND SUSPENSION § 901.20 Does this part apply to me? This part and...

40 CFR 1048.1 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 34 2012-07-01 2012-07-01 false Does this part apply to me? 1048.1 Section 1048.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... § 1048.1 Does this part apply to me? (a) The regulations in this part 1048 apply for all new, spark...

2 CFR 801.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 801.20 Section 801.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF VETERANS AFFAIRS NONPROCUREMENT DEBARMENT AND SUSPENSION § 801.20 Does this part apply to me? This part and...

40 CFR 63.5090 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Does this subpart apply to me? 63.5090 Section 63.5090 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Covers § 63.5090 Does this subpart apply to me? (a) The provisions of this subpart apply to each facility...

40 CFR 63.5683 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Does this subpart apply to me? 63.5683 Section 63.5683 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... subpart apply to me? (a) This subpart applies to you if you meet both of the criteria listed in paragraphs...

40 CFR 63.2981 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Does this subpart apply to me? 63.2981 Section 63.2981 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Subpart Covers § 63.2981 Does this subpart apply to me? You must comply with this subpart if you meet the...

22 CFR 1508.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Does this part apply to me? 1508.105 Section 1508.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.105 Does this part apply to me? Portions of this part (see table at § 1508.25(b...

2 CFR 5800.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 5800.20 Section 5800.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ELECTION ASSISTANCE COMMISSION NONPROCUREMENT DEBARMENT AND SUSPENSION § 5800.20 Does this part apply to me? This part and...

2 CFR 2429.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2429.20 Section 2429.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF... this part apply to me? This part, and through this part, pertinent portions of the OMB guidance in...

2 CFR 2336.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2336.20 Section 2336.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2336.20 Does this part apply to me? This part and...

2 CFR 1532.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1532.20 Section 1532.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL PROTECTION AGENCY NONPROCUREMENT DEBARMENT AND SUSPENSION § 1532.20 Does this part apply to me? This part and...

2 CFR 2200.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2200.20 Section 2200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONPROCUREMENT DEBARMENT AND SUSPENSION § 2200.20 Does this part apply to me...

2 CFR 417.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 417.20 Section 417.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF AGRICULTURE NONPROCUREMENT DEBARMENT AND SUSPENSION § 417.20 Does this part apply to me? Through this part...

2 CFR 376.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 376.20 Section 376.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH AND HUMAN SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 376.20 Does this part apply to me? This...

2 CFR 2339.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2339.20 Section 2339.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 2339.20 Does this part apply to me...

40 CFR 1048.1 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 34 2013-07-01 2013-07-01 false Does this part apply to me? 1048.1 Section 1048.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... § 1048.1 Does this part apply to me? (a) The regulations in this part 1048 apply for all new, spark...

2 CFR 3185.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3185.20 Section 3185.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements INSTITUTE OF MUSEUM AND LIBRARY SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3185.20 Does this part apply to me...

2 CFR 780.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 780.20 Section 780.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements AGENCY FOR INTERNATIONAL DEVELOPMENT NONPROCUREMENT DEBARMENT AND SUSPENSION § 780.20 Does this part apply to me? This part...

40 CFR 63.5683 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Does this subpart apply to me? 63.5683 Section 63.5683 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... § 63.5683 Does this subpart apply to me? (a) This subpart applies to you if you meet both of the...

2 CFR 1200.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 1200.20 Section 1200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF TRANSPORTATION NONPROCUREMENT SUSPENSION AND DEBARMENT § 1200.20 Does this part apply to me? This part and...

2 CFR 1880.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1880.20 Section 1880.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL AERONAUTICS AND SPACE ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 1880.20 Does this part apply to me...

2 CFR 2339.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2339.20 Section 2339.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 2339.20 Does this part apply to me...

2 CFR 3000.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3000.20 Section 3000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HOMELAND SECURITY NONPROCUREMENT DEBARMENT AND SUSPENSION § 3000.20 Does this part apply to me? This part...

49 CFR 32.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 49 Transportation 1 2010-10-01 2010-10-01 false Does this part apply to me? 32.105 Section 32.105 Transportation Office of the Secretary of Transportation GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 32.105 Does this part apply to me? (a) Portions of this part...

2 CFR 1326.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1326.20 Section 1326.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF COMMERCE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1326.20 Does this part apply to me? This part and...

33 CFR 120.100 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 33 Navigation and Navigable Waters 1 2012-07-01 2012-07-01 false Does this part apply to me? 120.100 Section 120.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SECURITY OF VESSELS SECURITY OF PASSENGER VESSELS General § 120.100 Does this part apply to me? This part...

40 CFR 1048.1 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 32 2010-07-01 2010-07-01 false Does this part apply to me? 1048.1 Section 1048.1 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR POLLUTION... § 1048.1 Does this part apply to me? (a) The regulations in this part 1048 apply for all new, spark...

2 CFR 2000.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2000.20 Section 2000.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements UNITED STATES... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

2 CFR 2600.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2600.20 Section 2600.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ARCHIVES... me? This part and, through this part, pertinent portions of the OMB guidance in subparts A through I...

40 CFR 63.2231 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Does this subpart apply to me? 63.2231 Section 63.2231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Subpart Covers § 63.2231 Does this subpart apply to me? This subpart applies to you if you meet the...

34 CFR 84.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 34 Education 1 2012-07-01 2012-07-01 false Does this part apply to me? 84.105 Section 84.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 84.105 Does this part apply to me? (a) Portions of...

40 CFR 63.2231 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Does this subpart apply to me? 63.2231 Section 63.2231 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Subpart Covers § 63.2231 Does this subpart apply to me? This subpart applies to you if you meet the...

2 CFR 2336.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 2336.20 Section 2336.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2336.20 Does this part apply to me? This part and...

2 CFR 1532.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1532.20 Section 1532.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL PROTECTION AGENCY NONPROCUREMENT DEBARMENT AND SUSPENSION § 1532.20 Does this part apply to me? This part and...

40 CFR 63.3290 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 13 2012-07-01 2012-07-01 false Does this subpart apply to me? 63.3290 Section 63.3290 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... Covers § 63.3290 Does this subpart apply to me? The provisions of this subpart apply to each new and...

2 CFR 376.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 376.20 Section 376.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH AND HUMAN SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 376.20 Does this part apply to me? This...

22 CFR 1006.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Does this part apply to me? 1006.105 Section 1006.105 Foreign Relations INTER-AMERICAN FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1006.105 Does this part apply to me? Portions of this part (see table at § 1006.25(b...

34 CFR 84.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 34 Education 1 2013-07-01 2013-07-01 false Does this part apply to me? 84.105 Section 84.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 84.105 Does this part apply to me? (a) Portions of...

33 CFR 120.100 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 33 Navigation and Navigable Waters 1 2013-07-01 2013-07-01 false Does this part apply to me? 120.100 Section 120.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SECURITY OF VESSELS SECURITY OF PASSENGER VESSELS General § 120.100 Does this part apply to me? This part...

49 CFR 32.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 49 Transportation 1 2012-10-01 2012-10-01 false Does this part apply to me? 32.105 Section 32.105 Transportation Office of the Secretary of Transportation GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 32.105 Does this part apply to me? (a) Portions of this part...

2 CFR 1200.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1200.20 Section 1200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF TRANSPORTATION NONPROCUREMENT SUSPENSION AND DEBARMENT § 1200.20 Does this part apply to me? This part and...

2 CFR 3369.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3369.20 Section 3369.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT FOR THE HUMANITIES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3369.20 Does this part apply to me? This...

2 CFR 1326.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 1326.20 Section 1326.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF COMMERCE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1326.20 Does this part apply to me? This part and...

40 CFR 267.190 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.190 Section 267.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Tank Systems § 267.190 Does this subpart apply to me? This subpart applies to you if you own or...

22 CFR 1508.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 2 2010-04-01 2010-04-01 true Does this part apply to me? 1508.105 Section 1508.105 Foreign Relations AFRICAN DEVELOPMENT FOUNDATION GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 1508.105 Does this part apply to me? Portions of this part (see table at § 1508.25(b...

40 CFR 63.5683 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 13 2013-07-01 2012-07-01 true Does this subpart apply to me? 63.5683 Section 63.5683 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... § 63.5683 Does this subpart apply to me? (a) This subpart applies to you if you meet both of the...

2 CFR 1125.30 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 1125.30 Section 1125.30 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF DEFENSE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1125.30 Does this part apply to me? This part and...

2 CFR 1536.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1536.20 Section 1536.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... to me? This part and, through this part, pertinent portions of the OMB guidance in Subparts A through...

2 CFR 3513.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3513.20 Section 3513.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements EXPORT-IMPORT BANK OF THE UNITED STATES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3513.20 Does this part apply to me...

2 CFR 2245.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2245.20 Section 2245.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR... this part apply to me? This part and, through this part, pertinent portions of the OMB guidance in...

40 CFR 267.190 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Does this subpart apply to me? 267.190 Section 267.190 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Tank Systems § 267.190 Does this subpart apply to me? This subpart applies to you if you own or...

2 CFR 801.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 801.20 Section 801.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF VETERANS AFFAIRS NONPROCUREMENT DEBARMENT AND SUSPENSION § 801.20 Does this part apply to me? This part and...

2 CFR 2429.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2429.20 Section 2429.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF... this part apply to me? This part, and through this part, pertinent portions of the OMB guidance in...

2 CFR 1536.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1536.20 Section 1536.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... to me? This part and, through this part, pertinent portions of the OMB guidance in Subparts A through...

2 CFR 1326.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1326.20 Section 1326.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF COMMERCE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1326.20 Does this part apply to me? This part and...

2 CFR 421.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 421.20 Section 421.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF AGRICULTURE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 421.20 Does this part apply to me...

2 CFR 2336.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2336.20 Section 2336.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2336.20 Does this part apply to me? This part and...

2 CFR 1125.30 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1125.30 Section 1125.30 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF DEFENSE NONPROCUREMENT DEBARMENT AND SUSPENSION § 1125.30 Does this part apply to me? This part and...

14 CFR 1267.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 14 Aeronautics and Space 5 2010-01-01 2010-01-01 false Does this part apply to me? 1267.105 Section 1267.105 Aeronautics and Space NATIONAL AERONAUTICS AND SPACE ADMINISTRATION GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

2 CFR 782.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 782.20 Section 782.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements AGENCY FOR... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

2 CFR 2336.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 2336.20 Section 2336.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SOCIAL SECURITY ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2336.20 Does this part apply to me? This part and...

2 CFR 2700.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 2700.20 Section 2700.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SMALL BUSINESS ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2700.20 Does this part apply to me? This part and...

33 CFR 120.100 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Does this part apply to me? 120.100 Section 120.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SECURITY OF VESSELS SECURITY OF PASSENGER VESSELS General § 120.100 Does this part apply to me? This part...

2 CFR 2200.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2200.20 Section 2200.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR NATIONAL AND COMMUNITY SERVICE NONPROCUREMENT DEBARMENT AND SUSPENSION § 2200.20 Does this part apply to me...

2 CFR 421.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 421.20 Section 421.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF AGRICULTURE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 421.20 Does this part apply to me...

40 CFR 63.2981 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 40 Protection of Environment 12 2010-07-01 2010-07-01 true Does this subpart apply to me? 63.2981 Section 63.2981 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) AIR PROGRAMS... § 63.2981 Does this subpart apply to me? You must comply with this subpart if you meet the criteria in...

2 CFR 5800.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 5800.20 Section 5800.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements ELECTION ASSISTANCE COMMISSION NONPROCUREMENT DEBARMENT AND SUSPENSION § 5800.20 Does this part apply to me? This part and...

2 CFR 2700.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 2700.20 Section 2700.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements SMALL BUSINESS ADMINISTRATION NONPROCUREMENT DEBARMENT AND SUSPENSION § 2700.20 Does this part apply to me? This part and...

49 CFR 32.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 49 Transportation 1 2013-10-01 2013-10-01 false Does this part apply to me? 32.105 Section 32.105 Transportation Office of the Secretary of Transportation GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 32.105 Does this part apply to me? (a) Portions of this part...

2 CFR 2600.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2600.20 Section 2600.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ARCHIVES... me? This part and, through this part, pertinent portions of the OMB guidance in subparts A through I...

2 CFR 2245.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 2245.20 Section 2245.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements CORPORATION FOR... this part apply to me? This part and, through this part, pertinent portions of the OMB guidance in...

40 CFR 267.110 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Does this subpart apply to me? 267.110 Section 267.110 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES... PERMIT Closure § 267.110 Does this subpart apply to me? This subpart applies to you if you own or operate...

33 CFR 120.100 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 33 Navigation and Navigable Waters 1 2011-07-01 2011-07-01 false Does this part apply to me? 120.100 Section 120.100 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY SECURITY OF VESSELS SECURITY OF PASSENGER VESSELS General § 120.100 Does this part apply to me? This part...

2 CFR 3513.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 3513.20 Section 3513.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements EXPORT-IMPORT BANK OF THE UNITED STATES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3513.20 Does this part apply to me...

Epigenetic modifications and glucocorticoid sensitivity in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS).

PubMed

de Vega, Wilfred C; Herrera, Santiago; Vernon, Suzanne D; McGowan, Patrick O

2017-02-23

Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a debilitating idiopathic disease characterized by unexplained fatigue that fails to resolve with sufficient rest. Diagnosis is based on a list of symptoms and exclusion of other fatigue-related health conditions. Despite a heterogeneous patient population, immune and hypothalamic-pituitary-adrenal (HPA) axis function differences, such as enhanced negative feedback to glucocorticoids, are recurring findings in ME/CFS studies. Epigenetic modifications, such as CpG methylation, are known to regulate long-term phenotypic differences and previous work by our group found DNA methylome differences in ME/CFS, however the relationship between DNA methylome modifications, clinical and functional characteristics associated with ME/CFS has not been examined. We examined the DNA methylome in peripheral blood mononuclear cells (PBMCs) of a larger cohort of female ME/CFS patients using the Illumina HumanMethylation450 BeadChip Array. In parallel to the DNA methylome analysis, we investigated in vitro glucocorticoid sensitivity differences by stimulating PBMCs with phytohaemagglutinin and suppressed growth with dexamethasone. We explored DNA methylation differences using bisulfite pyrosequencing and statistical permutation. Linear regression was implemented to discover epigenomic regions associated with self-reported quality of life and network analysis of gene ontology terms to biologically contextualize results. We detected 12,608 differentially methylated sites between ME/CFS patients and healthy controls predominantly localized to cellular metabolism genes, some of which were also related to self-reported quality of life health scores. Among ME/CFS patients, glucocorticoid sensitivity was associated with differential methylation at 13 loci. Our results indicate DNA methylation modifications in cellular metabolism in ME/CFS despite a heterogeneous patient population, implicating these processes in immune and HPA

Production of 14 MeV neutrons by heavy ions

DOEpatents

Brugger, Robert M.; Miller, Lowell G.; Young, Robert C.

1977-01-01

This invention relates to a neutron generator and a method for the production of 14 MeV neutrons. Heavy ions are accelerated to impinge upon a target mixture of deuterium and tritium to produce recoil atoms of deuterium and tritium. These recoil atoms have a sufficient energy such that they interact with other atoms of tritium or deuterium in the target mixture to produce approximately 14 MeV neutrons.

Letter from Prashant Gupta, Honeywell to Galo Jackson, USEPA. Subject: Draft Feasibility Study Report for OU1 (Estuary), LCP Chemicals Site

EPA Pesticide Factsheets

March 29, 2013 cover letter and report for Operable Unit 1 (OU1) to evaluate potential remedial measures at LCP Chemicals site in Brunswick, Georgia. Region ID : 04, DocID: 10940624 , DocDate: 2013-03-29

PubMedAlertMe - Standalone Windows-based PubMed SDI Software Application

PubMed Central

Ma’ayan, Avi

2008-01-01

PubMedAlertMe is a Windows-based software system for automatically receiving e-mail alert messages about recent publications listed on PubMed. The e-mail messages contain links to newly available abstracts listed on PubMed describing publications that were selectively returned from a specified list of queries. Links are also provided to directly export citations to EndNote, and links are provided to directly forward articles to colleagues. The program is standalone. Thus, it does not require a remote mail server or user registration. PubMedAlertMe is free software, and can be downloaded from: http://amp.pharm.mssm.edu/PubMedAlertMe/PubMedAlertMe_setup.zip PMID:18402930

Development of economic MeV-ion microbeam technology at Chiang Mai University

NASA Astrophysics Data System (ADS)

Singkarat, S.; Puttaraksa, N.; Unai, S.; Yu, L. D.; Singkarat, K.; Pussadee, N.; Whitlow, H. J.; Natyanum, S.; Tippawan, U.

2017-08-01

Developing high technologies but in economic manners is necessary and also feasible for developing countries. At Chiang Mai University, Thailand, we have developed MeV-ion microbeam technology based on a 1.7-MV Tandetron tandem accelerator with our limited resources in a cost-effective manner. Instead of using expensive and technically complex electrostatic or magnetic quadrupole focusing lens systems, we have developed cheap MeV-ion microbeams using programmed L-shaped blade aperture and capillary techniques for MeV ion beam lithography or writing and mapping. The programmed L-shaped blade micro-aperture system consists of a pair of L-shaped movable aperture pieces which are controlled by computer to cut off the ion beam for controlling the beam size down to the micrometer order. The capillary technique utilizes our home-fabricated tapered glass capillaries to realize microbeams. Either system can be installed inside the endstation of the MeV ion beam line of the accelerator. Both systems have been applied to MeV-ion beam lithography or writing of micro-patterns for microfluidics applications to fabricate lab-on-chip devices. The capillary technique is being developed for MeV-ion beam mapping of biological samples. The paper reports details of the techniques and introduces some applications.

2 CFR 902.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 902.20 Section 902.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) § 902.20 Does this part apply to me...

21 CFR 1405.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-04-01

... 21 Food and Drugs 9 2012-04-01 2012-04-01 false Does this part apply to me? 1405.105 Section 1405.105 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1405.105 Does this part apply to me? (a) Portions of...

45 CFR 1155.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Does this part apply to me? 1155.105 Section 1155.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... (FINANCIAL ASSISTANCE) Purpose and Coverage § 1155.105 Does this part apply to me? (a) Portions of this part...

31 CFR 19.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 31 Money and Finance: Treasury 1 2013-07-01 2013-07-01 false Does this part apply to me? 19.105 Section 19.105 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 19.105 Does this part apply to me? Portions of this part...

2 CFR 376.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 376.20 Section 376.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH AND HUMAN SERVICES NONPROCUREMENT DEBARMENT AND SUSPENSION § 376.20 Does this part apply to me? This...

2 CFR 601.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 601.20 Section 601.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF STATE NONPROCUREMENT DEBARMENT AND SUSPENSION § 601.20 Does this part apply to me? This part and, through this part...

31 CFR 19.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 31 Money and Finance: Treasury 1 2012-07-01 2012-07-01 false Does this part apply to me? 19.105 Section 19.105 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 19.105 Does this part apply to me? Portions of this part...

2 CFR 1401.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 1401.105 Section 1401.105 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE... this part apply to me? This part and, through this part, pertinent portions of the OMB guidance in...

45 CFR 630.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Does this part apply to me? 630.105 Section 630.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... this part apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an...

21 CFR 822.4 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 8 2013-04-01 2013-04-01 false Does this part apply to me? 822.4 Section 822.4 Food and Drugs FOOD AND DRUG ADMINISTRATION, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICAL DEVICES POSTMARKET SURVEILLANCE General Provisions § 822.4 Does this part apply to me? If we have...

45 CFR 630.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Does this part apply to me? 630.105 Section 630.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... this part apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an...

2 CFR 3700.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3700.20 Section 3700.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements PEACE CORPS NONPROCUREMENT DEBARMENT AND SUSPENSION § 3700.20 Does this part apply to me? This part and, through this part...

2 CFR 382.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 382.20 Section 382.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH....20 Does this part apply to me? This part and, through this part, pertinent portions of the OMB...

2 CFR 1532.1105 - Does this subpart apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this subpart apply to me? 1532.1105 Section 1532.1105 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... the Clean Air Act and Clean Water Act § 1532.1105 Does this subpart apply to me? (a) Portions of this...

2 CFR 3700.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3700.20 Section 3700.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements PEACE CORPS NONPROCUREMENT DEBARMENT AND SUSPENSION § 3700.20 Does this part apply to me? This part and, through this part...

21 CFR 1405.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 21 Food and Drugs 9 2013-04-01 2013-04-01 false Does this part apply to me? 1405.105 Section 1405.105 Food and Drugs OFFICE OF NATIONAL DRUG CONTROL POLICY GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 1405.105 Does this part apply to me? (a) Portions of...

2 CFR 3186.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 3186.20 Section 3186.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements INSTITUTE OF MUSEUM... part apply to me? This part and, through this part, pertinent portions of the OMB guidance in Subparts...

34 CFR 85.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 34 Education 1 2010-07-01 2010-07-01 false Does this part apply to me? 85.105 Section 85.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 85.105 Does this part apply to me? Portions of this part (see table at § 85.25(b...

2 CFR 601.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 601.20 Section 601.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF STATE NONPROCUREMENT DEBARMENT AND SUSPENSION § 601.20 Does this part apply to me? This part and, through this part...

29 CFR 1472.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 29 Labor 4 2011-07-01 2011-07-01 false Does this part apply to me? 1472.105 Section 1472.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

2 CFR 801.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 801.20 Section 801.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF VETERANS AFFAIRS NONPROCUREMENT DEBARMENT AND SUSPENSION § 801.20 Does this part apply to me? This part and...

2 CFR 3513.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3513.20 Section 3513.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements EXPORT-IMPORT BANK OF THE UNITED STATES NONPROCUREMENT DEBARMENT AND SUSPENSION § 3513.20 Does this part apply to me...

2 CFR 1401.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 1401.105 Section 1401.105 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF THE... this part apply to me? This part and, through this part, pertinent portions of the OMB guidance in...

2 CFR 601.20 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this part apply to me? 601.20 Section 601.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF STATE NONPROCUREMENT DEBARMENT AND SUSPENSION § 601.20 Does this part apply to me? This part and, through this part...

22 CFR 208.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-04-01

... 22 Foreign Relations 1 2010-04-01 2010-04-01 false Does this part apply to me? 208.105 Section 208.105 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 208.105 Does this part apply to me? Portions of this part (see table at § 208.25(b...

22 CFR 208.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 1 2011-04-01 2011-04-01 false Does this part apply to me? 208.105 Section 208.105 Foreign Relations AGENCY FOR INTERNATIONAL DEVELOPMENT GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 208.105 Does this part apply to me? Portions of this part (see table at § 208.25(b...

45 CFR 1155.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 45 Public Welfare 3 2010-10-01 2010-10-01 false Does this part apply to me? 1155.105 Section 1155.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... (FINANCIAL ASSISTANCE) Purpose and Coverage § 1155.105 Does this part apply to me? (a) Portions of this part...

45 CFR 1155.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 45 Public Welfare 3 2011-10-01 2011-10-01 false Does this part apply to me? 1155.105 Section 1155.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... (FINANCIAL ASSISTANCE) Purpose and Coverage § 1155.105 Does this part apply to me? (a) Portions of this part...

2 CFR 3186.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3186.20 Section 3186.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements INSTITUTE OF MUSEUM... part apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts...

2 CFR 3254.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 3254.20 Section 3254.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements NATIONAL ENDOWMENT FOR THE ARTS NONPROCUREMENT DEBARMENT AND SUSPENSION § 3254.20 Does this part apply to me? This part...

43 CFR 2806.11 - How will BLM charge me rent?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 43 Public Lands: Interior 2 2013-10-01 2013-10-01 false How will BLM charge me rent? 2806.11 Section 2806.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... POLICY MANAGEMENT ACT Rents General Provisions § 2806.11 How will BLM charge me rent? (a) BLM will charge...

34 CFR 85.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 34 Education 1 2011-07-01 2011-07-01 false Does this part apply to me? 85.105 Section 85.105 Education Office of the Secretary, Department of Education GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 85.105 Does this part apply to me? Portions of this part (see table at § 85.25(b...

2 CFR 1532.1105 - Does this subpart apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this subpart apply to me? 1532.1105 Section 1532.1105 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... the Clean Air Act and Clean Water Act § 1532.1105 Does this subpart apply to me? (a) Portions of this...

31 CFR 19.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-07-01

... 31 Money and Finance: Treasury 1 2011-07-01 2011-07-01 false Does this part apply to me? 19.105 Section 19.105 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 19.105 Does this part apply to me? Portions of this part...

2 CFR 1532.1105 - Does this subpart apply to me?

Code of Federal Regulations, 2010 CFR

2010-01-01

... 2 Grants and Agreements 1 2010-01-01 2010-01-01 false Does this subpart apply to me? 1532.1105 Section 1532.1105 Grants and Agreements Federal Agency Regulations for Grants and Agreements ENVIRONMENTAL... the Clean Air Act and Clean Water Act § 1532.1105 Does this subpart apply to me? (a) Portions of this...

22 CFR 312.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-04-01

... 22 Foreign Relations 2 2013-04-01 2009-04-01 true Does this part apply to me? 312.105 Section 312.105 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 312.105 Does this part apply to me? (a) Portions of this part apply to you...

2 CFR 382.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 382.20 Section 382.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

2 CFR 901.20 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-01-01

... 2 Grants and Agreements 1 2011-01-01 2011-01-01 false Does this part apply to me? 901.20 Section 901.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF ENERGY Reserved NONPROCUREMENT DEBARMENT AND SUSPENSION § 901.20 Does this part apply to me? This part and...

45 CFR 1155.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-10-01

... 45 Public Welfare 3 2013-10-01 2013-10-01 false Does this part apply to me? 1155.105 Section 1155.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL FOUNDATION ON THE ARTS... (FINANCIAL ASSISTANCE) Purpose and Coverage § 1155.105 Does this part apply to me? (a) Portions of this part...

45 CFR 630.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-10-01

... 45 Public Welfare 3 2012-10-01 2012-10-01 false Does this part apply to me? 630.105 Section 630.105 Public Welfare Regulations Relating to Public Welfare (Continued) NATIONAL SCIENCE FOUNDATION... this part apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an...

29 CFR 1472.105 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-07-01

... 29 Labor 4 2013-07-01 2013-07-01 false Does this part apply to me? 1472.105 Section 1472.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

29 CFR 1472.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 29 Labor 4 2010-07-01 2010-07-01 false Does this part apply to me? 1472.105 Section 1472.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

43 CFR 43.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-10-01

... 43 Public Lands: Interior 1 2010-10-01 2010-10-01 false Does this part apply to me? 43.105 Section 43.105 Public Lands: Interior Office of the Secretary of the Interior GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 43.105 Does this part apply to me? (a...

31 CFR 19.105 - Does this part apply to me?

Code of Federal Regulations, 2010 CFR

2010-07-01

... 31 Money and Finance: Treasury 1 2010-07-01 2010-07-01 false Does this part apply to me? 19.105 Section 19.105 Money and Finance: Treasury Office of the Secretary of the Treasury GOVERNMENTWIDE DEBARMENT AND SUSPENSION (NONPROCUREMENT) General § 19.105 Does this part apply to me? Portions of this part...

22 CFR 312.105 - Does this part apply to me?

Code of Federal Regulations, 2011 CFR

2011-04-01

... 22 Foreign Relations 2 2011-04-01 2009-04-01 true Does this part apply to me? 312.105 Section 312.105 Foreign Relations PEACE CORPS GOVERNMENTWIDE REQUIREMENTS FOR DRUG-FREE WORKPLACE (FINANCIAL ASSISTANCE) Purpose and Coverage § 312.105 Does this part apply to me? (a) Portions of this part apply to you...

43 CFR 2806.11 - How will BLM charge me rent?

Code of Federal Regulations, 2011 CFR

2011-10-01

... 43 Public Lands: Interior 2 2011-10-01 2011-10-01 false How will BLM charge me rent? 2806.11 Section 2806.11 Public Lands: Interior Regulations Relating to Public Lands (Continued) BUREAU OF LAND... POLICY MANAGEMENT ACT Rents General Provisions § 2806.11 How will BLM charge me rent? (a) BLM will charge...

29 CFR 1472.105 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-07-01

... 29 Labor 4 2012-07-01 2012-07-01 false Does this part apply to me? 1472.105 Section 1472.105 Labor Regulations Relating to Labor (Continued) FEDERAL MEDIATION AND CONCILIATION SERVICE GOVERNMENTWIDE... apply to me? (a) Portions of this part apply to you if you are either— (1) A recipient of an assistance...

2 CFR 382.20 - Does this part apply to me?

Code of Federal Regulations, 2012 CFR

2012-01-01

... 2 Grants and Agreements 1 2012-01-01 2012-01-01 false Does this part apply to me? 382.20 Section 382.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...

2 CFR 382.20 - Does this part apply to me?

Code of Federal Regulations, 2013 CFR

2013-01-01

... 2 Grants and Agreements 1 2013-01-01 2013-01-01 false Does this part apply to me? 382.20 Section 382.20 Grants and Agreements Federal Agency Regulations for Grants and Agreements DEPARTMENT OF HEALTH... apply to me? This part and, through this part, pertinent portions of the OMB guidance in subparts A...