Science.gov

Sample records for brothers big sisters

  1. Making a Difference in Schools: The Big Brothers Big Sisters School-Based Mentoring Impact Study

    ERIC Educational Resources Information Center

    Herrera, Carla; Grossman, Jean Baldwin; Kauh, Tina J.; Feldman, Amy F.; McMaken, Jennifer

    2007-01-01

    School-based mentoring is one of the fastest growing forms of mentoring in the US today; yet, few studies have rigorously examined its impacts. This landmark random assignment impact study of Big Brothers Big Sisters School-Based Mentoring is the first national study of this program model. It involves 10 agencies, 71 schools and 1,139 9- to…

  2. Making a Difference. An Impact Study of Big Brothers/Big Sisters.

    ERIC Educational Resources Information Center

    Tierney, Joseph P.; And Others

    This report provides reliable evidence that mentoring programs can positively affect young people. The evidence is derived from research conducted at local affiliates of Big Brothers/Big Sisters of America (BB/BSA), the oldest, best-known, and arguably most sophisticated of the country's mentoring programs. Public/Private Ventures, Inc. conducted…

  3. Serving, Learning and Mentoring through the Big Brothers Big Sisters Program

    ERIC Educational Resources Information Center

    Sivukamaran, Thillainatarajan; Holland, Glenda; Clark, Leonard J.

    2010-01-01

    This study describes the collaborative partnership between a Big Brothers Big Sisters organization, an elementary school and the College of Education at a public university. The partnership utilized a mentoring system consisting of elementary students, college students, elementary teachers and university faculty. Benefits of the various…

  4. Untapped Potential: Fulfilling the Promise of Big Brothers Big Sisters and the Bigs and Littles They Represent

    ERIC Educational Resources Information Center

    Bridgeland, John M.; Moore, Laura A.

    2010-01-01

    American children represent a great untapped potential in our country. For many young people, choices are limited and the goal of a productive adulthood is a remote one. This report paints a picture of who these children are, shares their insights and reflections about the barriers they face, and offers ways forward for Big Brothers Big Sisters as…

  5. High School Students as Mentors: Findings from the Big Brothers Big Sisters School-Based Mentoring Impact Study

    ERIC Educational Resources Information Center

    Herrera, Carla; Kauh, Tina J.; Cooney, Siobhan M.; Grossman, Jean Baldwin; McMaken, Jennifer

    2008-01-01

    High schools have recently become a popular source of mentors for school-based mentoring (SBM) programs. The high school Bigs program of Big Brothers Big Sisters of America, for example, currently involves close to 50,000 high-school-aged mentors across the country. While the use of these young mentors has several potential advantages, their age…

  6. An Evaluation of Parental Assessment of the Big Brothers/Big Sisters Program in New York City.

    ERIC Educational Resources Information Center

    Frecknall, Peter; Luks, Alan

    1992-01-01

    Parents rated impact of Big Brother/Big Sister program on children along variables of school attendance, grades, family relationship, friendship, self-esteem, staying out of trouble, being responsible, frequency of contact, and length of time in program. Although children were rated as benefiting significantly from program, children's frequency of…

  7. Are youth mentoring programs good value-for-money? An evaluation of the Big Brothers Big Sisters Melbourne Program

    PubMed Central

    Moodie, Marjory L; Fisher, Jane

    2009-01-01

    Background The Big Brothers Big Sisters (BBBS) program matches vulnerable young people with a trained, supervised adult volunteer as mentor. The young people are typically seriously disadvantaged, with multiple psychosocial problems. Methods Threshold analysis was undertaken to determine whether investment in the program was a worthwhile use of limited public funds. The potential cost savings were based on US estimates of life-time costs associated with high-risk youth who drop out-of-school and become adult criminals. The intervention was modelled for children aged 10–14 years residing in Melbourne in 2004. Results If the program serviced 2,208 of the most vulnerable young people, it would cost AUD 39.5 M. Assuming 50% were high-risk, the associated costs of their adult criminality would be AUD 3.3 billion. To break even, the program would need to avert high-risk behaviours in only 1.3% (14/1,104) of participants. Conclusion This indicative evaluation suggests that the BBBS program represents excellent 'value for money'. PMID:19178749

  8. When Your Brother or Sister Has Cancer

    Cancer.gov

    Tips on what to say to your friends, how to deal with stress, and where to find support – as well as information about cancer and cancer treatments, for young people who have a brother or sister with cancer.

  9. Brothers and Sisters: A Source of Support for Children in School?

    ERIC Educational Resources Information Center

    Hadfield, Lucy; Edwards, Rosalind; Mauthner, Melanie

    2006-01-01

    Whilst UK schools move towards U.S "big brother" style mentoring systems for children, are actual brothers and sisters becoming an invisible source of support to deal with bullying in everyday life? This paper reports on research with children aged 7-13 about their experiences and understandings of their relationships with their brothers and…

  10. The Ubiquity of Big Brother

    ERIC Educational Resources Information Center

    Longstreth, Langdon E.; And Others

    1975-01-01

    The influence of an older brother on the physical activity or passivity of younger brothers and sisters was examined through teacher observations of children in kindergarten through sixth grade and through self reports of college students. Study included whites and Mexican Americans. (CW)

  11. Big Sisters: An Experimental Evaluation.

    ERIC Educational Resources Information Center

    Seidl, Fredrick W.

    1982-01-01

    Assessed the effects of participation in a Big Sisters' Program. The first part consisted of interviews (N=20) with pairs of Big Sisters-Little Sisters. The second part evaluated program effectiveness experimentally. Findings indicated positive relationships between pairs, and improved behavior of experimental girls versus controls. (RC)

  12. Testing of the "Healthy 'Little' Lives Project": A Training Program for Big Sister Mentors

    ERIC Educational Resources Information Center

    Kaufman, Michelle R.

    2010-01-01

    Big Brothers/Big Sisters is a national program aimed at providing mentors for disadvantaged children. This study tested whether Big Sister mentors could be trained to increase communication with their Little Sisters about sexual health issues. The study tested an intervention based on social cognitive theory in which a sexual health communication…

  13. Adult Sibling Relationships with Brothers and Sisters with Severe Disabilities

    ERIC Educational Resources Information Center

    Rossetti, Zach; Hall, Sarah

    2015-01-01

    The purpose of this qualitative study was to examine perceptions of adult sibling relationships with a brother or sister with severe disabilities and the contexts affecting the relationships. Adult siblings without disabilities (N = 79) from 19 to 72 years of age completed an online survey with four open-ended questions about their relationship…

  14. Freud on Brothers and Sisters: A Neglected Topic

    ERIC Educational Resources Information Center

    Sherwin-White, Susan

    2007-01-01

    This paper explores Freud's developing thought on brothers and sisters, and their importance in his psychoanalytical writings and clinical work. Freud's work on sibling psychology has been seriously undervalued. This paper aims to give due recognition to Freud's work in this area. (Contains 1 note.)

  15. Sisters, Brothers, and Delinquency: Evaluating Social Influence during Early and Middle Adolescence.

    ERIC Educational Resources Information Center

    Slomkowski, Cheryl; Rende, Richard; Conger, Katherine J.; Simons, Ronald L.; Conger, Rand D.

    2001-01-01

    Examined sibling influence on delinquency in 164 brother and sister pairs over 4-year period. Found that sibling similarity for self-reports of delinquent behavior were highly correlated for brothers and sisters. Conditional effects of high hostile-coercive relationships and older sibling delinquency predicted younger sibling delinquency in both…

  16. Adolescents' Sex-Typed Friendship Experiences: Does Having a Sister versus a Brother Matter?

    ERIC Educational Resources Information Center

    Updegraff, Kimberly A.; McHale, Susan M.; Crouter, Ann C.

    2000-01-01

    Examined connections between having a sister versus a brother and coming from a same-sex versus an opposite-sex sibling dyad, and sex-typing in adolescents' friendships. Findings suggested that sisters may learn control tactics from brothers that they apply in friendships. Boys were less likely to model emotional intimacy. Coming from opposite-sex…

  17. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... the parent dies. (c) The last month for which such brother or sister is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...

  18. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the parent dies. (c) The last month for which such brother or sister is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...

  19. 20 CFR 725.223 - Duration of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the parent dies. (c) The last month for which such brother or sister is entitled to benefits is the month before the month in which any of the following events first occurs: (1) The individual dies;...

  20. The Role of Brothers and Sisters in the Gender Development of Preschool Children.

    ERIC Educational Resources Information Center

    Rust, John; Golombok, Susan; Hines, Melissa; Johnston, Katie; Golding, Jean

    2000-01-01

    Examined whether the sex of older siblings influenced the gender role development of 3-year-olds. Found that boys with older brothers and girls with older sisters were more sex-typed than same-sex singletons who, in turn, were more sex-typed than children with other-sex siblings. Having an older brother was associated with more masculine and less…

  1. Living with a Brother Who Has an Autism Spectrum Disorder: A Sister's Perspective

    ERIC Educational Resources Information Center

    Connell, Zara O.; Halloran, Maeve O.; Doody, Owen

    2016-01-01

    People with Autism Spectrum Disorder (ASD) are born into families and influence family functioning both positively and negatively. One of the most enduring relationships a person with ASD will have is their relationship with a brother or sister. Services for people with ASD should provide effective support to families, which include brothers,…

  2. Improving Emotion Regulation and Sibling Relationship Quality: The More Fun with Sisters and Brothers Program

    ERIC Educational Resources Information Center

    Kennedy, Denise E.; Kramer, Laurie

    2008-01-01

    We examined the role of emotion regulation (ER) in improving sibling relationship quality (SRQ) by evaluating the More Fun With Sisters and Brothers Program where 4- to 8-year-old siblings from 95 families were taught emotional and social competencies. Parents reported on SRQ and ER, and sibling interactions were observed in homes. SRQ and ER…

  3. Variations in the Educational and Career Development Paths of Brothers and Sisters.

    ERIC Educational Resources Information Center

    Mott, Frank L.; Haurin, R. Jean

    A study examined the extent to which socioeconomic and internal characteristics of families differentially affect ability of matched pairs of brothers and sisters to progress through the educational system. The data sets used were the National Longitudinal Surveys of Work Experience of Young Men and Women who were originally interviewed in 1966…

  4. Brother-Sister Incest: Data from Anonymous Computer-Assisted Self Interviews

    ERIC Educational Resources Information Center

    Stroebel, Sandra S.; O'Keefe, Stephen L.; Beard, Keith W.; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The…

  5. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  6. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  7. 20 CFR 410.340 - Determination of relationship; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of relationship; parent, brother, or sister. 410.340 Section 410.340 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship...

  8. 20 CFR 410.380 - Determination of dependency; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Determination of dependency; parent, brother, or sister. 410.380 Section 410.380 Employees' Benefits SOCIAL SECURITY ADMINISTRATION FEDERAL COAL MINE HEALTH AND SAFETY ACT OF 1969, TITLE IV-BLACK LUNG BENEFITS (1969- ) Relationship and...

  9. Family Adaptation and Coping among Siblings of Cancer Patients, Their Brothers and Sisters, and Nonclinical Controls.

    ERIC Educational Resources Information Center

    Madan-Swain, Avi; And Others

    1993-01-01

    Examined coping and family adaptation in siblings (n=32) of cancer patients, their ill brothers and sisters (n=19), and control group of nonclinical children (n=10) with healthy siblings. Gender and age of sibling, birth order, and number of siblings were examined. Found better adaptation in larger families and decreased family involvement among…

  10. Brother-sister incest: data from anonymous computer-assisted self interviews.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Beard, Keith W; Kuo, Shih-Ya; Swindell, Samuel; Stroupe, Walter

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using computer-assisted self interview. Forty were classified as victims of brother-sister incest, 19 were classified as victims of father-daughter incest, and 232 were classified as victims of sexual abuse by an adult other than their father before reaching 18 years of age. The other 1,230 served as controls. The victims of brother-sister incest had significantly more problematic outcomes than controls on many measures (e.g., more likely than the controls to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). However, victims of brother-sister incest also had significantly less problematic outcomes than victims of father-daughter incest on some measures (e.g., significantly less likely than the father-daughter incest victims to endorse feeling like damaged goods, thinking that they had suffered psychological injury, and having undergone psychological treatment for childhood sexual abuse). PMID:23590349

  11. Catholic Nursing Sisters and Brothers and Racial Justice in Mid-20th-Century America

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This historical article considers nursing’s work for social justice in the 1960s civil rights movement through the lens of religious sisters and brothers who advocated for racial equality. The article examines Catholic nurses’ work with African Americans in the mid-20th century that took place amid the prevailing social conditions of poverty and racial disempowerment, conditions that were linked to serious health consequences. Historical methodology is used within the framework of “bearing witness,” a term often used in relation to the civil rights movement and one the sisters themselves employed. Two situations involving nurses in the mid-20th century are examined: the civil rights movement in Selma, Alabama, and the actions for racial justice in Chicago, Illinois. The thoughts and actions of Catholic sister and brother nurses in the mid-20th century are chronicled, including those few sister nurses who stepped outside their ordinary roles in an attempt to change an unjust system entirely. PMID:19461224

  12. Perceptions of "Big Sisters" and Their "Little Sisters" Regarding Mentoring Relationships

    ERIC Educational Resources Information Center

    Quarles, Alice; Maldonado, Nancy L.; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    This qualitative study explored the relationships between six Little Sisters (mentees) and their Big Sisters (mentors) to develop an understanding of the perceptions of high-risk adolescent female mentees and their mentors regarding their mentoring relationships. Participants were purposefully selected--those actively involved in a formal…

  13. Educational and occupational achievements of brothers and sisters in adoptive and biologically related families.

    PubMed

    Scarr, S; Weinberg, R A

    1994-07-01

    The study of brothers and sisters from adoptive and biologically related families permits unique analyses of the determinants of young adults' educational and occupational achievements. Brothers and sisters come from the same homes, neighborhoods, and usually schools. Many differences among families are controlled by the study of siblings. In addition, adoptive families influence their children only through the environment they provide, whereas biologically related parents transmit their intellectual and personal characteristics to their offspring genetically as well. Thus, the comparison of models of adult achievements for children from adoptive and biologically related families can inform us about the true effects of family environments, apart from genetic transmission (Scarr and Weinberg, 1978, 1980). In this follow-up study of 450 biologically related and adopted young adults (ages 22 to 30 years), we report on the family resemblances in educational and occupational achievements. Parents' reports were obtained on 97% of the original sample (N = 443), and 77% of the young adults participated in the follow-up study themselves; complete educational and occupational data were available on 303 young adults. Results show that biological sons are more influenced by their family backgrounds than daughters, regardless of genetic relatedness. A second finding is that young women's achievements are not as predictable from their own earlier achievements as are those of their brothers. A third finding is that parents invest in their sons' educational futures, regardless of sons' abilities and achievements, in ways they do not invest in their daughters' postsecondary educations. Sibling correlations and natural mother-adopted child correlations suggest that test scores, high school performance, postsecondary education, and even later occupational status can be influenced by genetic variability in personal characteristics that affect such achievements. PMID:7993309

  14. Incestuous Sisters: Mate Preference for Brothers over Unrelated Males in Drosophila melanogaster

    PubMed Central

    Loyau, Adeline; Cornuau, Jérémie H.; Clobert, Jean; Danchin, Étienne

    2012-01-01

    The literature is full of examples of inbreeding avoidance, while recent mathematical models predict that inbreeding tolerance or even inbreeding preference should be expected under several realistic conditions like e.g. polygyny. We investigated male and female mate preferences with respect to relatedness in the fruit fly D. melanogaster. Experiments offered the choice between a first order relative (full-sibling or parent) and an unrelated individual with the same age and mating history. We found that females significantly preferred mating with their brothers, thus supporting inbreeding preference. Moreover, females did not avoid mating with their fathers, and males did not avoid mating with their sisters, thus supporting inbreeding tolerance. Our experiments therefore add empirical evidence for inbreeding preference, which strengthens the prediction that inbreeding tolerance and preference can evolve under specific circumstances through the positive effects on inclusive fitness. PMID:23251487

  15. Birth order and ratio of brothers to sisters in Spanish transsexuals.

    PubMed

    Gómez-Gil, Esther; Esteva, Isabel; Carrasco, Rocío; Almaraz, M Cruz; Pasaro, Eduardo; Salamero, Manel; Guillamon, Antonio

    2011-06-01

    Three Western studies have shown that male-to-female (MF) homosexual transsexuals tend to be born later than their siblings and to come from sibships with more brothers than sisters. The objective of this study was to determine whether these variables would be replicated in 530 MF and female-to-male (FM) Spanish transsexuals according to sexual orientation. The results showed that MF homosexual transsexuals had significantly more older brothers than the non-homosexual MF group. Compared with the expected rates in the general population, birth order was significantly higher in both MF (Slater's Index = 0.59; Fraternal Index = 0.61; Sororal Index = 0.58) and FM homosexual transsexuals (Slater's Index = 0.65; Fraternal Index = 0.68; Sororal Index = 0.67), and sibling sex ratio was significantly higher than expected in homosexual MF (sex ratio = 0.55) but not in homosexual FM transsexuals. No significant differences were found in the non-homosexual subgroups. The replication of the later birth order and sibling sex-ratio effect in MF homosexual transsexuals corroborates previous findings in a variety of groups from different cultures and may suggest a common mechanism underlying the etiology of transsexualism. PMID:20232130

  16. Challenging stereotypes? The older woman in the TV series Brothers & Sisters.

    PubMed

    Oró-Piqueras, Maricel

    2014-12-01

    The TV series, Brothers & Sisters, broadcast from 2006 to 2011 by ABC (USA) and a year later by Channel 4 (UK) with quite high audience rates, starts when the patriarchal figure, William Walker, dies of a heart attack and two female figures around their sixties come center stage: his wife, Nora Walker, and his long-term lover, Holly Harper. Once the patriarchal figure disappears, the female characters regain visibility by entering the labor market and starting relationships with other men. In that sense, both protagonists experience aging as a time in which they are increasingly freed from social and family constraints. However, their roles as nurturers keep on bringing them back to the domestic space in which they are safe from being involved in uncomfortable and unsuitable situations. Drawing on previous studies on the representation of the older woman in fictional media, this article intends to discern to what extent stereotypes related to the older woman are challenged through the two main protagonists of a contemporary TV series. PMID:25456618

  17. Effects of older brother-younger sister incest: a study of the dynamics of 17 cases.

    PubMed

    Laviola, M

    1992-01-01

    The purpose of this study was to explore the effects of older brother-younger sister incest from the perspective of the women who experienced it in childhood or adolescent years. Dynamics in the families-of-origin were also explored, as these related or contributed to the effects from the incest. Seventeen women were interviewed, using an in-depth, semi-structured interview. Four self-report objective instruments were also administered that measure dynamics in the family-of-origin and symptomatology that is often associated with the effects of trauma. Interview and objective data were analyzed by systematically organizing the women's perceptions and conceptualizations into common themes. All of the women's families of origin were described as dysfunctional. Common effects reported included mistrust of men and women, chronic low or negative self-esteem, sexual response difficulties, and intrusive thoughts of the incest. Women regarded individual therapy, talking with supportive family and friends, and validating themselves as victims at the time of the incest as ways in which they have helped themselves to deal with the effects of the incest. These results have important implications for therapy, including serious consideration of the impact and contribution of this kind of incest on reported symptomatology, and on emerging issues and conflicts in the therapeutic process. PMID:1617475

  18. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... the case of a brother, he also: (1) Is under 18 years of age; or (2) Is 18 years of age or older and... 20 Employees' Benefits 2 2010-04-01 2010-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent,...

  19. 20 CFR 410.214 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... the case of a brother, he also: (1) Is under 18 years of age; or (2) Is 18 years of age or older and... 20 Employees' Benefits 2 2011-04-01 2011-04-01 false Conditions of entitlement; parent, brother...; Duration of Entitlement; Filing of Claims and Evidence § 410.214 Conditions of entitlement; parent,...

  20. Learning English through Social Interaction: The Case of "Big Brother 2006," Finland

    ERIC Educational Resources Information Center

    Kaanta, Leila; Jauni, Heidi; Leppanen, Sirpa; Peuronen, Saija; Paakkinen, Terhi

    2013-01-01

    In line with recent Conversation Analytic work on language learning as situated practice, this article investigates how interactants can create language learning opportunities for themselves and others in and through social interaction. The study shows how the participants of "Big Brother Finland," a reality TV show, whose main…

  1. A resolution recognizing the 100-year anniversary of Big Brothers Big Sisters Southeastern Pennsylvania.

    THOMAS, 113th Congress

    Sen. Toomey, Pat [R-PA

    2014-12-11

    12/11/2014 Submitted in the Senate, considered, and agreed to without amendment and with a preamble by Unanimous Consent. (consideration: CR S6698; text as passed Senate: CR S6631) (All Actions) Tracker: This bill has the status Passed SenateHere are the steps for Status of Legislation:

  2. Super Mario brothers and sisters: Associations between coplaying video games and sibling conflict and affection.

    PubMed

    Coyne, Sarah M; Jensen, Alexander C; Smith, Nathan J; Erickson, Daniel H

    2016-02-01

    Video games can be played in many different contexts. This study examined associations between coplaying video games between siblings and levels of affection and conflict in the relationship. Participants were 508 adolescents (M age = 16.31 years of age, SD = 1.08) who completed questionnaires on video game use and sibling relationships. Participants were recruited from a large Northwestern city and a moderate city in the Mountain West of the United States. Video games played between siblings were coded by an independent sample to assess levels of physical aggression and prosocial behavior in each game. Playing video games with a sibling was associated with higher levels of sibling affection for both boys and girls, but higher levels of conflict for boys only. Playing a violent video game with a brother was associated with lower levels of conflict in the sibling relationship, whereas playing a prosocial video game was not related to any sibling outcome. The value of video games in sibling relationships will be discussed, with a focus on the type of game and the sex of the adolescent. PMID:26748076

  3. Big brother.

    PubMed

    Cross, M

    1993-04-15

    Both purchasers and providers will need to change the way they hold patient records on computer, or they could find themselves in breach of the law. Michael Cross examines a report by the Data Protection Registrar. PMID:10126013

  4. Intrafamilial Sexual Abuse: Brother-Sister Incest Does Not Differ from Father-Daughter and Stepfather-Stepdaughter Incest.

    ERIC Educational Resources Information Center

    Cyr, Mireille; Wright, John; McDuff, Pierre; Perron, Alain

    2002-01-01

    A study compared 72 girls (ages 5-16) sexually abused by brothers, fathers, or stepfathers. Results suggested few differences in characteristics of sexual abuse. However, penetration was much more frequent in the sibling incest group. More victims of fathers and brothers manifested clinically significant distress (90%), than stepfather victims…

  5. Brothers & Sisters Talk with PACER.

    ERIC Educational Resources Information Center

    Binkard, Betty; And Others

    This booklet presents excerpts from interviews with siblings (ages 10-28) of persons with a range of handicaps, including Down Syndrome, cerebral palsy, learning disabilities, deafness, autism, seizure disorder, genetic disorders, and mental retardation. It is arranged in order from the youngest person interviewed and continues through…

  6. Big Brother Not Needed.

    ERIC Educational Resources Information Center

    Heinen, Edward

    1983-01-01

    Cites the recent United States State Department's labeling of recent Canadian films--one on nuclear war and two on acid rain--as political propaganda as a sign of the need to review the nature of propaganda. Suggests that teaching students to intelligently evaluate propaganda is preferable to submitting to government dictum. (MM)

  7. Big Brother I. Q.

    ERIC Educational Resources Information Center

    Gilliatt, Michael T.

    1977-01-01

    Lists four harmful consequences that critics suggest educational testing may have, and in discussing the danger that I.Q. testing may place an indelible stamp of inferiority upon students, this research re-examines the purpose of testing. (Author/RK)

  8. Comparison between high-resolution climate simulations using single- and double-nesting approaches within the Big-Brother experimental protocol

    NASA Astrophysics Data System (ADS)

    Matte, Dominic; Laprise, René; Thériault, Julie Mireille

    2016-02-01

    Regional climate models (RCM) are widely used to downscale global climate models' (GCMs) simulations. As the resolution of RCM increases faster than that of GCM used for climate-change projections till the end of this century, the resolution jump will become an issue. Cascade with multiple nesting offers an approach to reach high resolution while keeping reasonable computational cost. Few studies have addressed whether the best results are obtained with the single- or multiple-nesting approaches. In this study the results obtained with single and double nesting are compared within the idealised "perfect model" framework of the Big-Brother Experiment. This method consists in first realizing a simulation, nicknamed the Big-Brother (BB) simulation, on a relatively large domain at the desired resolution, to serve as reference dataset. The BB results are then processed by a low-pass filter to emulate a coarse-resolution dataset to be used as LBC to drive further simulations, nicknamed the Little-Brother (LB) simulations, using an identical model formulation and resolution as the BB simulation. For the single nesting, the LB simulations are directly simulated, while for the double nesting a surrogate intermediate-resolution simulation is used. The study of the time-mean (stationary) component shows that little difference is noted between the single- and double-nesting approaches. The time-deviation (transient-eddy) component, however, shows important differences. The double-nesting approach weakly degrades the large scales but allows a significant reduction of the required domain size to allow adequate spin-up of fine-scale features. This results in an important saving in the computational cost.

  9. Bah's Baby Brother Is Born.

    ERIC Educational Resources Information Center

    Tapahonso, Luci

    This illustrated story, written for Native American children, stresses the importance of not drinking alcohol and taking care of oneself during pregnancy. The story centers on Bah, a young Native American girl whose mother is going to have a baby. Bah is very excited about getting a baby brother or sister and wants the baby to be healthy and…

  10. Prolegomenon to the Study of "Brother" as a Male Family Role.

    ERIC Educational Resources Information Center

    Arkin, William

    1979-01-01

    Directs the reader to sibling gender relationships. Patterns of intimacy in brother-brother and brother-sister relationships are identified. Masculine gender role patterns were expressed more frequently than classic sibling rivalry. Sisters, not mothers, were discovered to be the primary socializing agent for some of men's intimate relationships…

  11. Considerations on domain location according to the jump of resolution between the driving data and the nested regional climate model within the Big-Brother experiment.

    NASA Astrophysics Data System (ADS)

    Matte, D.; Laprise, R.; Theriault, J. M.; Lucas-Picher, P.

    2015-12-01

    Many studies have shown the importance of choosing the domain size adequately for dynamical downscaling with nested regional climate models. It is well known that domain should not be too large to avoid large departure from the driving data, and not be too small to provide sufficient distance from the lateral inflow to allow a full development of the small-scale features resolved by the increase resolution. Although practitioners of dynamical downscaling are well aware that the jump of resolution between the driving data and the nested regional climate model impacts the simulated climate, the issue has never been properly study. Larger is the jump of resolution, larger is the distance from the lateral inflow to fully develop the small-scale features permitted by the increase resolution. Our investigation compares direct nesting to achieve a grid mesh of 0.15o from driving data at 3.6°, 1.8o, 0.45° and 0.15° using the perfect-prognostic approach of the Big-Brother protocol. The results show that the small-scale transient-eddy component struggles to be fully developed with reduced resolution of the driving data. Overall, this study suggests that domain location (i.e. domain of interest or subsequent nested domains) must be chosen carefully according to the jump of resolution to allow the optimal development of small-scale features allowed by the increase resolution of the nested model.

  12. My Brother Warren.

    ERIC Educational Resources Information Center

    Forbes, Eric

    1987-01-01

    The younger brother of a hyperactive, severely learning-disabled 21-year-old recounts his feelings regarding lack of parental attention, jealousy toward his older brother, embarrassment, and finally empathy for his older brother. (CB)

  13. Smile on Your Brother: Teaching Siblings Together

    ERIC Educational Resources Information Center

    Carter, Paula

    2008-01-01

    A multiage first, second, and third grade classroom includes brothers, sisters, cousins. Two teachers use a developmentally appropriate approach while juggling teaching responsibilities and administering the many tests required by No Child Left Behind. Carter explains their four priorities for children: attendance, responsibility, honesty, and…

  14. Teletext--Prestel's Big Brother.

    ERIC Educational Resources Information Center

    Hughes, Geoffrey

    Prestel, Oracle, and Ceefax are telephone based video text systems currently in use in Great Britain. Rather than being considered as competitors, they should be viewed as complementary media with separate functions based on their differences. All use home television sets to receive information in print, and all broadcast on spare TV lines in the…

  15. Sister-sister incest: data from an anonymous computerized survey.

    PubMed

    Stroebel, Sandra S; O'Keefe, Stephen L; Griffee, Karen; Kuo, Shih-Ya; Beard, Keith W; Kommor, Martin J

    2013-01-01

    Retrospective data were entered anonymously by 1,521 adult women using a computer-assisted self-interview. Thirty-one participants were victims of sister-sister incest, 40 were victims of brother-sister incest, 19 were victims of father-daughter incest, 8 were victims of sexual abuse by an adult female (including one mother), and 232 were victims of sexual abuse by an adult male other than their father before reaching 18 years of age. The rest (1,203) served as controls. The victims of sister-sister incest had significantly more problematic outcomes than controls on many measures as adults. Victims of sister-sister incest were more depressed and more likely than controls to be distant from the perpetrator-sister and to have traded sex for money, experienced an unplanned pregnancy, engaged in four different types of masturbation, and engaged in 13 different same-sex behaviors. Our findings were consistent with other reports of early eroticization and persistent hypereroticization of incest victims. PMID:23924178

  16. Sisters and Brothers, Brothers and Sisters in the Family Affected by Traumatic Brain Injury.

    ERIC Educational Resources Information Center

    Pieper, Betty

    This report is based on a qualitative research study which utilized a nominal group process to identify major life stressors for parents of children with traumatic brain injuries (TBI). It focuses first on effects of TBI on siblings and then on effective interventions. The first section uses quotes from participating parents to identify their…

  17. SISTER STUDY

    EPA Science Inventory

    The Sister Study will investigate the role of genetic, environmental, and lifestyle factors on the risk of breast cancer and other diseases in sisters of women with breast cancer. This research study will enroll 50,000 women who live in the United States and who are the cancer-fr...

  18. Immunological disorders and malignancies in five young brothers.

    PubMed Central

    Purtilo, D T; Riordan, J A; Deflorio, D; Yang, J P; Sun, P; Vawter, G

    1977-01-01

    Five brothers of from 6 to 18 years of age experienced immunological or neoplastic disorders during an 8-year interval. 2 boys succumbed to glioblastoma multiforme, another to metastatic carcinoma, and the 2 surviving brothers had a histiocytic lymphoma and idiopathic thrombocytopenia purpura, respectively. The mother of the boys was healthy, but her twin sister died in utero of birth defects. We suggest that an intrinsic cellular defect inherited from their mother rendered the boys vulnerable to oncogenesis. PMID:193448

  19. Trisomy 1q42{r_arrow}qter in a sister and brother: Further delineation of the {open_quotes}trisomy 1q42{r_arrow}qter syndrome{close_quotes}

    SciTech Connect

    Verschuuren-Bemelmans, C.C.; Leegte, B.; Hodenius, T.M.J.

    1995-07-31

    We report on a 22-year-old woman and her 21-year-old brother with mild mental retardation, long face, prominent forehead, retrognathia, and (relative) macrocephaly. At birth they were small for date, their length is now below the 10th centile. Chromosome analysis demonstrated a nearly pure trisomy 1q42{r_arrow}qter in both patients due to unbalanced segregation of a paternal reciprocal balanced translocation 46,XY,t(1;15) (q42;p11). This is the second report of a nearly pure trisomy 1q42{r_arrow}qter. When comparing the manifestations of our patients with those of other reported cases we conclude that the most characteristic clinical manifestations of this syndrome are macrocephaly, prominent forehead, micro/retrognathia, large fontanelle, intrauterine growth retardation, postnatal growth retardation, and mental retardation. 56 refs., 4 figs., 1 tab.

  20. The Perceptions and Experiences of Adolescent Siblings Who Have a Brother with Autism Spectrum Disorder

    ERIC Educational Resources Information Center

    Petalas, Michael A.; Hastings, Richard P.; Nash, Susie; Reilly, Deirdre; Dowey, Alan

    2012-01-01

    Background: There is a dearth of research on the perspectives of adolescent siblings growing up with a brother or sister with an autism spectrum disorder (ASD). Method: Semistructured interviews were used to elicit the perceptions and experiences of 12 typically developing adolescents with a brother with an ASD. Interpretative phenomenological…

  1. One Sister's Story

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues One Sister's Story Past Issues / Fall 2006 Table of ... NIH/NIEHS By Tina Hall Sister Study participant One day in April, after my sister returned from ...

  2. Babbitt's Brothers & Sisters: Raising Ethical Issues in Business Literature.

    ERIC Educational Resources Information Center

    Halpern, Jeanne W.

    A college-level course in business literature is an ideal place to raise and discuss ethical issues. To be successful, a teacher of this course must engage student interest, help the students articulate and understand their own ethical attitudes, clarify the stance and artistry of the author, and refine student responses to ethical questions. When…

  3. Brothers and Sisters: Molecular insights into arterial-venous heterogeneity

    PubMed Central

    Aitsebaomo, Julius; Portbury, Andrea L; Schisler, Jonathan C; Patterson, Cam

    2009-01-01

    The molecular differences between arteries and veins are genetically predetermined and are evident even before the first embryonic heart beat. Although ephrinB2 and EphB4 are expressed in cells that will ultimately differentiate into arteries and veins respectively, many other genes have been shown to play a significant role in cell fate determination. The expression patterns of ephrinB2 and EphB4 are restricted to arterial-venous boundaries, and Eph/ephrin signaling provides repulsive cues at arterial-venous boundaries that are thought to prevent intermixing of arterial- and venous-fated cells. However, the maintenance of arterial-venous fate is susceptible to some degree of plasticity. Thus, in response to signals from the ambient microenvironment and shear stress, there is flow-mediated intercalation of the arteries and veins that ultimately leads to the formation of a functional, closed-loop circulation. In addition, cells in the blood vessels of each organ undergo epigenetic, morphologic and functional adaptive changes that are specific to the proximate function of their cognate organ(s). These adaptive changes result in an inter-organ and intra-organ vessel heterogeneity that manifest clinically in a disparate response of different organs to identical risk factors and injury in the same animal. In this review, we will focus on the molecular and physiologic factors influencing arterial-venous heterogeneity between and within different organ(s). We will explore arterial-venous differences in selected organs as well as their respective endothelial cell architectural organization that results in their inter- and intra-organ heterogeneity. PMID:18948631

  4. Siblings of Oedipus: Brothers and Sisters of Incest Victims.

    ERIC Educational Resources Information Center

    de Young, Mary

    1981-01-01

    Investigates the roles and problems of siblings of incest victims, describes the dynamics of the incestuous family, and identifies some behavior problems of children whose siblings were incest victims. Data from two siblings' lives are presented to illustrate points. (Author/DB)

  5. Big Brother Is Not Watching You Act

    THOMAS, 113th Congress

    Rep. Grayson, Alan [D-FL-9

    2014-01-15

    03/20/2014 Referred to the Subcommittee on Crime, Terrorism, Homeland Security, and Investigations. (All Actions) Tracker: This bill has the status IntroducedHere are the steps for Status of Legislation:

  6. Mentoring At-Risk Adolescent Girls: Listening to "Little Sisters"

    ERIC Educational Resources Information Center

    Maldonado, Nancy L.; Quarles, Alice; Lacey, Candace H.; Thompson, Steve D.

    2008-01-01

    In order to develop an understanding of mentoring relationships and the impact these relationships might have on the development of high-risk adolescent girls, this qualitative study explored the relationships between six "Little Sisters" and their "Big Sister" mentors. The purposefully-selected sample includes women and girls who were actively…

  7. Brother to Brother: Success for African-American Males

    ERIC Educational Resources Information Center

    Henningsen, Stephanie

    2005-01-01

    This article discusses Brother to Brother, a program designed to help African-American men stay in college and graduate. St. Petersburg College formed this program seven years ago as a means not only of recruiting male African-American students, but also to identify issues that cause them to be at risk for dropping out and to use retention…

  8. 75 FR 71458 - Warner Brothers Entertainment, Inc., Warner Brothers Theatrical Enterprises, Including Workers of...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-23

    ... published in the Federal Register on November 17, 2009 (74 FR 59254). At the request of a company official... Employment and Training Administration Warner Brothers Entertainment, Inc., Warner Brothers Theatrical... Brothers Distributing, Inc., Warner Brothers Home Entertainment, Inc., Warner Brothers Studio...

  9. Where are Sedna's Sisters?

    NASA Astrophysics Data System (ADS)

    Bartlett, D. F.

    2005-05-01

    Simulations of the formation of the Oort cloud from the Kuiper Belt typically are presented as an animated scatter diagram. Here the orbit of each object appears as a point of perihelion distance q and semi-major axis a. (eg. Levison, Morbidelli, & Dones 2004). These plots show a conspicuous void, bounded by the inequalities: q < a, q > 50 AU, and a < 5000-10000 AU. Brown (2005) calls this void the ``Bermuda Triangle". The only present occupant is Sedna (q=76 AU, a=501 AU). Brown, Trujillo, & Rabinowitz , the discovers of Sedna, have challenged others to explain how Sedna got inside the triangle and to predict where similar objects might be found. Sedna could not have simply formed in its current orbit by the accumulation of smaller objects (Stern 2005). Several authors have suggested that a passing star scattered Sedna into the triangle shortly after the birth of the solar system. Here I offer an alternative which uses the very strong galactic tidal forces of the Sinusoidal potential (Bartlett 2001, 2004). In this potential, the numerator of Newton's law is replaced by GM cos(ko r) where ko = 2 π / lambdao and the 'wavelength' λ o is 425 pc. The 20 radial oscillations between the sun and the center of the Galaxy give tidal forces that are 120 times as big as generally expected. I will show how this tidal force, acting over the lifetime of the solar system, could move the perihelion of Sedna from about 40 to 76 AU. Sedna's sisters are likely to have still larger q & a and to have perihelia in two specific quadrants of the ecliptic plane.

  10. Goddard Welcomes SISTER

    NASA Video Gallery

    The Goddard Space Flight Center in Greenbelt, Md., hosted a weeklong summer institute, SISTER, for the purpose of increasing the awareness of and providing opportunities for middle school girls to ...

  11. Myelodysplastic syndrome in two young brothers.

    PubMed

    Hirose, M; Kawahito, M; Kuroda, Y

    1995-01-01

    We report the youngest cases of myelodysplastic syndrome (MDS) in two brothers aged 7 and 2 years. The maternal grandfather and maternal grandmother had been exposed to radioactive fallout after the atomic bomb attack on Hiroshima in 1945. The elder brother demonstrated pancytopenia with < 1% blast cells in his peripheral blood and < 5% in his bone marrow at diagnosis. The younger brother was thrombocytopenic without increased blasts. The karyotype of bone marrow cells from the elder brother was 46,XY, -7, +der (7), t(1:7) (lqter-lq11::7q11-7pter), but the younger brother's karyotype was normal. Immature myeloid cells in the bone marrow from both brothers were morphologically abnormal. A diagnosis of refractory anaemia (RA) was made in both brothers. Atavism due to radioactive poisoning was suspected in the development of MDS in these two cases. PMID:7833267

  12. The Prodigal Sister - Venus

    NASA Astrophysics Data System (ADS)

    Barlow, Nadine G.

    1995-09-01

    If you think Venus is a hellhole now, be thankful you weren't there 500 million years ago. Those were the days, many planetary scientists believe, of apocalypse on our sister world: Volcanoes wracked the land, while greenhouse gases broiled the air. Is this the Earth's fate, too?

  13. "My Brother Likes Meeting New People, but Don't Ask Him Any Direct Questions": Involving Adults with Autism plus Learning Disability in a Qualitative Research Project

    ERIC Educational Resources Information Center

    Tozer, Rosemary; Atkin, Karl; Wenham, Aniela

    2014-01-01

    Adult siblings of people with autism and a learning disability have hitherto been largely overlooked by research, policy and practice in the UK. As part of a qualitative study focussing on adult siblings, we met twelve people with autism plus severe learning disability with their brother or sister. Individually tailored resources were used to make…

  14. Three brothers with algodystrophy of the hip.

    PubMed Central

    Albert, J; Ott, H

    1983-01-01

    We describe the clinical features of algodystrophy of the hip in 3 brothers, probably the first familial presentation of this disease to be reported. The symptoms and evolution of the disease are as usually described. The familial presentation suggests a genetic predisposition. HLA typing showed an identity of antigenic formula in the 3 brothers, a rare coincidence. Images PMID:6882038

  15. 76 FR 79019 - Wright Brothers Day, 2011

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    .... (Presidential Sig.) [FR Doc. 2011-32761 Filed 12-19-11; 11:15 am] Billing code 3295-F2-P ... December 20, 2011 Part III The President Proclamation 8767--Wright Brothers Day, 2011 Memorandum of... ] Proclamation 8767 of December 15, 2011 Wright Brothers Day, 2011 By the President of the United States...

  16. 77 FR 75503 - Wright Brothers Day, 2012

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-20

    ... Independence of the United States of America the two hundred and thirty- seventh. (Presidential Sig.) [FR Doc... December 20, 2012 Part II The President Proclamation 8918--Wright Brothers Day, 2012 #0; #0; #0... Brothers Day, 2012 By the President of the United States of America A Proclamation After years of...

  17. 78 FR 76969 - Wright Brothers Day, 2013

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-19

    .... (Presidential Sig.) [FR Doc. 2013-30463 Filed 12-18-13; 11:15 am] Billing code 3295-F4 ... December 19, 2013 Part III The President Proclamation 9071--Wright Brothers Day, 2013 #0; #0; #0... Brothers Day, 2013 By the President of the United States of America A Proclamation On December 17,...

  18. 75 FR 80669 - Wright Brothers Day, 2010

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-22

    ... States of America the two hundred and thirty-fifth. (Presidential Sig.) [FR Doc. 2010-32402 Filed 12-21... Proclamation 8617--Wright Brothers Day, 2010 #0; #0; #0; Presidential Documents #0; #0; #0;#0;Federal Register... President ] Proclamation 8617 of December 17, 2010 Wright Brothers Day, 2010 By the President of the...

  19. Examining Big Brother's Purpose for Using Electronic Performance Monitoring

    ERIC Educational Resources Information Center

    Bartels, Lynn K.; Nordstrom, Cynthia R.

    2012-01-01

    We examined whether the reason offered for electronic performance monitoring (EPM) influenced participants' performance, stress, motivation, and satisfaction. Participants performed a data-entry task in one of five experimental conditions. In one condition, participants were not electronically monitored. In the remaining conditions, participants…

  20. Telemonitoring in heart failure: Big Brother watching over you.

    PubMed

    Dierckx, R; Pellicori, P; Cleland, J G F; Clark, A L

    2015-01-01

    Heart failure (HF) is a leading cause of hospitalisations in older people. Several strategies, supported by novel technologies, are now available to monitor patients' health from a distance. Although studies have suggested that remote monitoring may reduce HF hospitalisations and mortality, the study of different patient populations, the use of different monitoring technologies and the use of different endpoints limit the generalisability of the results of the clinical trials reported, so far. In this review, we discuss the existing home monitoring modalities, relevant trials and focus on future directions for telemonitoring. PMID:24972644

  1. Schooling for Humanity: When Big Brother Isn't Watching.

    ERIC Educational Resources Information Center

    Solmitz, David O.

    Most educational reform initiatives of the past 20 years are geared towards ensuring that the United States dominates the emerging global economy. What is lost in this rush to the top of the materialist heap is an education for the more enduring human values: creativity, intellectual development, care, social justice, and democracy. In this book,…

  2. Big Brother Is Watching: Video Surveillance on Buses

    ERIC Educational Resources Information Center

    Sloggett, Joel

    2009-01-01

    Many school districts in North America have adopted policies to permit cameras on their properties and, when needed, on buses used to transport students. With regard to school buses, the camera is typically a tool for gathering information to monitor behavior or to help investigate a complaint about behavior. If a picture is worth a thousand…

  3. Adjustment, Sibling Problems and Coping Strategies of Brothers and Sisters of Children with Autistic Spectrum Disorder

    ERIC Educational Resources Information Center

    Ross, Penelope; Cuskelly, Monica

    2006-01-01

    Background: Siblings of children with autistic spectrum disorder (ASD) express more problem behaviours and experience more difficulties in their relationships than do children in families where all children are developing typically. We know little about what contributes to these difficulties. Method: Mothers of a child with ASD completed the…

  4. Everyday Learning about Brothers & Sisters. Everyday Learning Series. Volume 3, Number 2

    ERIC Educational Resources Information Center

    Mackey, Gerrie

    2005-01-01

    The "Everyday Learning" series has been developed to focus attention on the everyday ways in which children can be supported in their growth and development. It is for all those who are involved in children's development and learning, including early childhood professionals in all children's services, parents, grandparents and others with an…

  5. The Brothers and Sisters Learn To Write: Popular Literacies in Childhood and School Cultures.

    ERIC Educational Resources Information Center

    Dyson, Anne Haas

    Building on the author's groundbreaking work in "Building Superheroes," this book traces the influence of a wide-ranging set of "textual toys" from children's lives--church and hip-hop songs, rap music, movies, TV, traditional jump-rope rhymes, the words of professional sports announcers and radio deejays--upon school learning and writing. The…

  6. When Your Brother or Sister Has Cancer: A Guide for Teens

    MedlinePlus

    ... care for people who are ill or disabled Nutritionist/ dietitian A health professional with special training in ... with patients and their families about emotional and personal matters and helps them make decisions, but does ...

  7. Why "Brother and Sister" Are Not Just "Siblings": Repair Processes in Agreement Computation

    ERIC Educational Resources Information Center

    Molinaro, Nicola; Vespignani, Francesco; Zamparelli, Roberto; Job, Remo

    2011-01-01

    In the present study we analyze how the cognitive system deals on-line with number agreement mismatches and whether this on-line process influences the off-line interpretation of the sentence. In two ERP experiments we monitored the on-line processing consequences of subject-verb agreement mismatches, focusing on the integration of a following…

  8. "You Can Do Nasty Things to Your Brothers and Sisters without a Reason": Siblings' Backstage Behaviour

    ERIC Educational Resources Information Center

    Punch, Samantha

    2008-01-01

    This article contributes to the recent, but still limited, literature on the sociology of sibship. It argues that during childhood the ambivalent love/hate nature of sibship is played out through the sharing of knowledge, time and space. It draws on the work of Goffman to illustrate that children's sibling interactions tend to consist of…

  9. Effects of Older Brother-Younger Sister Incest: A Study of the Dynamics of 17 Cases.

    ERIC Educational Resources Information Center

    Laviola, Marisa

    1992-01-01

    This study of 17 cases of incest between siblings found the women commonly experienced mistrust of men and women, chronic low or negative self-esteem, sexual response difficulties, and intrusive thoughts of the incest. Individual therapy, talking with supportive family and friends, and validating themselves as victims were seen as helpful.…

  10. Mothers' Differential Treatment of Adolescent Siblings: Predicting College Attendance of Sisters versus Brothers

    ERIC Educational Resources Information Center

    Bissell-Havran, Joanna M.; Loken, Eric; McHale, Susan M.

    2012-01-01

    Current estimates suggest that by 2015, 60% of college students will be women, a change since 1970 when 59% were men. We investigated family dynamics that might explain the growing gender gap in college attendance, focusing on an ethnically diverse sample of 522 mixed sex sibling dyads from the National Longitudinal Study of Adolescent Health. We…

  11. Brothers, Sisters and Fictive Kin: Communication about Sex among Urban Black Siblings

    ERIC Educational Resources Information Center

    Wallace, Scyatta A.; Hooper, Lisa M.; Persad, Malini

    2014-01-01

    Siblings have been shown to influence youth substance use and violent behavior. However, limited research has examined sibling-influences on sexual activity, particularly among urban Black youth. The current qualitative research was an exploratory study to describe discussions among siblings about sex and sexual health. Individual interviews were…

  12. 20 CFR 725.222 - Conditions of entitlement; parent, brother, or sister.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... disabled due to pneumoconiosis at the time of death or to have died due to pneumoconiosis. A surviving... establish that the miner's death was due to pneumoconiosis in order to establish entitlement to...

  13. Sibling Relationships and Adjustment in Children with Disabled and Nondisabled Brothers and Sisters.

    ERIC Educational Resources Information Center

    McHale, Susan M.; And Others

    A study was made of relationships between particular family dynamics and the well-being of children with disabled siblings. Attention focused on the relation to children's adjustment of three issues emphasized in the literature: (1) children's family responsibilities, including sibling caregiving and household tasks, which may be more demanding…

  14. Neuromyelitis optica in Japanese sisters.

    PubMed

    Tanaka, Yuji; Yoshikura, Nobuaki; Harada, Naoko; Yamada, Megumi; Koumura, Akihiro; Sakurai, Takeo; Hayashi, Yuichi; Kimura, Akio; Hozumi, Isao; Moriwaki, Hisataka; Inuzuka, Takashi

    2011-01-01

    We report cases of Japanese sisters with neuromyelitis optica (NMO). The elder sister was 25, when she was diagnosed with right optic neuritis. After 3 months, she developed left optic neuritis and myelitis. At age 27, she had the second relapse, but she has been free from episodes thereafter. The younger sister was 26, when she was diagnosed with optic neuritis. Thus far, she has 9 relapses, comprising both myelitis and optic neuritis. Both sisters had normal brain MRI scans, longitudinally extensive transverse myelitis over 3 vertebral segments, and positive results for anti-aquaporin-4 antibody (AQAP4Ab). They fulfilled the Wingerchuk criteria for definite NMO. Both sisters shared some immunogenetic factors, but they were not exposed to the same environmental factors after their early twenties. The final disability status was almost the same in both cases, and both showed a very benign course. These data suggest that genetic factors affect the age at onset and environmental factors may affect the frequency of relapse. PMID:22082898

  15. Writing siblings: Alice James and her brothers.

    PubMed

    Hoffman, Anne Golomb

    2015-02-01

    This essay addresses the relationship of writing to embodiment, through representations of bodily sensation and fantasy in the journal of Alice James. It considers Alice James's writing in relation to her two writer brothers, William and Henry, and in light of their father's experiences of impairment and breakdown. PMID:25688678

  16. My Brother's Keeper

    ERIC Educational Resources Information Center

    Obama, Barack

    2014-01-01

    In a White House address, the president announced an initiative to reclaim young boys and men of color. The "My Brother's Keeper" initiative partners with businesses, foundations, and nonprofits to address disparities in education, justice, and employment. President Obama was introduced by Christian, one of a group of students from…

  17. Pleural mesothelioma in a couple of brothers

    PubMed Central

    Bianchi, Claudio; Bianchi, Tommaso

    2013-01-01

    Malignant mesotheliomas of the pleura, epithelial type, were observed in two brothers. Both the patients had histories of severe exposure to asbestos, having worked as insulators. The latency periods in the two cases were 26 and 38 years, respectively. Available literature data suggest that mesothelioma occurrence among blood-related people is favored by a genetic predisposition. PMID:24872671

  18. Transient global amnesia in four brothers

    PubMed Central

    Corston, Richard N; Godwin-Austen, Richard B

    1982-01-01

    The case histories are described of four brothers who suffered attacks of transient global amnesia. The coincidence of this disorder in four siblings suggests that the causative factors in transient global amnesia may have a familial basis and that its incidence is more common than generally realised. PMID:7077349

  19. Build Your Own Wright Brothers' Glider

    ERIC Educational Resources Information Center

    Schimmel, Gordon; Hand, Jon; Ellis, Art

    2003-01-01

    A little more than one hundred years ago, Wilbur and Orville Wright began building models of airfoils and testing them in wind tunnels in their search for an efficient wing. Models continue to be used today by aerospace engineers to prove concepts and launch dreams. To celebrate the centennial of the Wright brothers' historic flight, the authors…

  20. The Shannoniella sisters (Diptera: Rhinophoridae).

    PubMed

    Nihei, Silvio S; Andrade, Marcos R; Pape, Thomas; Cerretti, Pierfilippo

    2016-01-01

    Shannoniella cuspidata Townsend, 1939 is redescribed and S. setinervis sp. nov. (Brazil, State of Rio de Janeiro) is newly described as its putative sister taxon, thereby allowing for a strict definition of the genus Shannoniella Townsend, 1939 through explicit synapomorphies. An identification key is provided. PMID:27395483

  1. All in the Family: The Sister Study

    MedlinePlus

    ... Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / Fall 2006 Table of ... in their daily lives. Want to Volunteer for the Sister Study? To volunteer or learn more about ...

  2. A Brief Analysis of Sister Carrie's Character

    ERIC Educational Resources Information Center

    Yu, Hanying

    2010-01-01

    Carrie is always dreaming while the rocking chair is rocking again and again, this is the deep impression on us after we read "Sister Carrie" which is the first novel of Theodore Dreiser. In this novel the protagonist Sister Carrie is a controversial person. This paper tries to analyze the character of Sister Carrie in order to find out…

  3. Sister R. Leadership: Doing the Seemingly Impossible

    ERIC Educational Resources Information Center

    Sena, Rachel; Schoorman, Dilys; Bogotch, Ira

    2013-01-01

    Sister R., the first author, is a Dominican Sister of Peace. Until recently, Sister R. had been the director of the Maya Ministry Family Literacy Program, working with the Maya Community in Lake Worth, Palm Beach County, Florida. She described her work with these indigenous, preliterate, hardworking peoples as "a university of the poor" in which…

  4. Two Sisters with Rett Syndrome. Brief Report.

    ERIC Educational Resources Information Center

    Haenggeli, Charles A.; And Others

    1990-01-01

    Clinical histories and physical findings are presented for 2 sisters with Rett syndrome. The older sister, age 25, was typically affected, whereas the younger sister, 22 years old, was affected with a seizure disorder showing an unusually early onset. The paper discusses hypotheses in genetic causation of Rett syndrome. (JDD)

  5. Brotherly Love? The Manipulation of Body Boundaries

    ERIC Educational Resources Information Center

    Beck, Benjamin

    2011-01-01

    This article is about a street-wise boy who is unaware that his younger brother has been using clever manipulation to get him into trouble. Nicholas is a 12-year-old boy whose father was recently given a life sentence for murder. Nicholas is in a boxing league and uses his fighting skills on the streets. Angel is Nicholas' nine-year-old brother…

  6. The Mayo brothers: an American surgical legacy.

    PubMed

    Toledo-Pereyra, Luis H

    2010-10-01

    Few in the history of surgery and just as few in the history of medicine can reach the level of clinical visibility as achieved by the Mayo brothers. The brothers changed the face of medicine while they were alive, and their fame and influence continued to grow after their death in 1939. The Mayo American surgical legacy had incredible proportions. The brothers systematically modified the field as few others had done before. They were great surgical innovators who took the surgical techniques of others and added a touch of their own to make the surgical procedure better and more secure. The Mayos were the stars regionally, nationally, and around the world. They attracted attention from their generation and occupied center stage long after. To speak of the Mayos is to speak of the quintessential American values of professionalism, respect, commitment, and caring for their fellow human beings. Their creation, the Mayo Clinic, surpassed the wildest hopes and predictions that anyone could have had regarding their best dreams. PMID:20874478

  7. Beta-mannosidase deficiency: heterogeneous manifestation in the first female patient and her brother.

    PubMed

    Kleijer, W J; Hu, P; Thoomes, R; Boer, M; Huijmans, J G; Blom, W; Van Diggelen, O P; Seemanova, E; Macek, M

    1990-01-01

    beta-Mannosidase deficiency was demonstrated in fibroblasts of a girl who showed severe psychomotor retardation, bone deformities and gargoylism and recurrent skin and respiratory infections and who died at 20 years of age from bronchopneumonia. This first demonstration of a female patient confirms the autosomal recessive inheritance of beta-mannosidosis. Further investigation of this gypsy family revealed beta-mannosidosis in an older brother with a milder manifestation of gargoyl facial dysmorphology, mental retardation, hearing impairment and recurrent infections. beta-Mannosidase activity was completely deficient in his cultured skin fibroblasts, leukocytes and plasma. In urine a characteristic disaccharide was present. Heterozygote levels of beta-mannosidase were found in fibroblasts and/or plasma of the parents and one sister. PMID:2079835

  8. Bram Stoker's brother, the brain surgeon.

    PubMed

    Stiles, Anne

    2013-01-01

    This essay examines the life and work of Sir William Thornley Stoker, 1st Baronet (1845-1912), the eldest brother of Bram Stoker (1847-1912), the author of Dracula (1897). Sir William or "Thornley," as he was commonly known, was one of Ireland's leading physicians. He performed some of the first brain surgeries in Ireland using Sir David Ferrier's maps of the cerebral cortex. From 1879 into the twentieth century, Thornley served as inspector for Ireland under the 1876 Cruelty to Animals Act. In this role, Thornley was responsible for granting licenses to researchers who performed experiments on live animals. Due to his reservations about animal experimentation, Thornley eventually became an advocate for the antivivisection cause, testifying at the second Royal Commission on Vivisection (1906-1912). Thornley also influenced Irish literature, albeit indirectly. Bram Stoker's composition notes for Dracula show that he consulted his older brother about the medical scenes in his novel. Thornley's knowledge of cerebral localization and his animal rights advocacy both surface in Dracula. PMID:24290266

  9. Authentic Expression of Edmund Rice Christian Brother Education

    ERIC Educational Resources Information Center

    Vercruysse, Raymond J.

    2007-01-01

    In 1802, Edmund Rice directed the laying of the foundation stone for Mount Sion Monastery and School. After several previous attempts of instructing poor boys in Waterford, this was to be the first permanent home for the Congregation of Christian Brothers. Rice's dream of founding a religious community of brothers was becoming a reality with a…

  10. 78 FR 45061 - Safety Zone; Sister Bay Marina Fest Fireworks and Ski Show, Sister Bay, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-26

    ...The Coast Guard is establishing a temporary safety zone on Sister Bay near Sister Bay, WI. This safety zone is intended to restrict vessels from a portion of Sister Bay due to a fireworks display and ski show. This temporary safety zone is necessary to protect the surrounding public and vessels from the hazards associated with the fireworks display and ski show in Sister Bay on August 31,...

  11. Big Society, Big Deal?

    ERIC Educational Resources Information Center

    Thomson, Alastair

    2011-01-01

    Political leaders like to put forward guiding ideas or themes which pull their individual decisions into a broader narrative. For John Major it was Back to Basics, for Tony Blair it was the Third Way and for David Cameron it is the Big Society. While Mr. Blair relied on Lord Giddens to add intellectual weight to his idea, Mr. Cameron's legacy idea…

  12. The sister bonding of duplicated chromosomes

    PubMed Central

    Zou, Hui

    2011-01-01

    Sister chromatid cohesion and separation are two fundamental chromosome dynamics that are essential to equal chromosome segregation during cell proliferation. In this review, I will discuss the major steps that regulate these dynamics during mitosis, with an emphasis on vertebrate cells. The implications of these machineries outside of sister chromatid cohesion and separation are also discussed. PMID:21497666

  13. "Brother Anonymous" and the Quiet Revolution in Quebec Education.

    ERIC Educational Resources Information Center

    Bennett, Paul W.; Jones, Richard A.

    1986-01-01

    This article offers a brief review of the writing of Jean-Paul Desbiens, an educational reformer and Quebec education official known as "Brother Anonymous." Juxtaposes two different articles by Desbiens, exposing the contradictions and conflicts between them. (JDH)

  14. [Mucopolysaccharidosis IS: Scheie's syndrome. A report of 2 brothers].

    PubMed

    Bonora, G; Frattini, D; Nedbal, M; Massironi, C; Perletti, L

    1991-01-01

    We describe two brothers affected by MPS type IS (Scheie syndrome). Mucopolysaccharidosis type I consists of three clinical entities of varying severity, all due to alfalevo-iduronidase enzyme deficiency. The MPS IS in characterized by joint stiffness, aortic valve disease and corneal clouding. The intellect is normal. All these findings are present on our brothers; furthermore retinal degeneration also occurred. It could give in the future attendant deterioration of vision. PMID:1839643

  15. All in the Family: The Sister Study

    MedlinePlus

    Skip Navigation Bar Home Current Issue Past Issues All in the Family: The Sister Study Past Issues / ... that may ultimately eliminate this dreaded disease. We all know that breast cancer does not discriminate. Whether ...

  16. Eruptive history of South Sister, Oregon Cascades

    USGS Publications Warehouse

    Fierstein, J.; Hildreth, W.; Calvert, A.T.

    2011-01-01

    South Sister is southernmost and highest of the Three Sisters, three geologically dissimilar stratovolcanoes that together form a spectacular 20km reach along the Cascade crest in Oregon. North Sister is a monotonously mafic edifice as old as middle Pleistocene, Middle Sister a basalt-andesite-dacite cone built between 48 and 14ka, and South Sister is a basalt-free edifice that alternated rhyolitic and intermediate modes from 50ka to 2ka (largely contemporaneous with Middle Sister). Detailed mapping, 330 chemical analyses, and 42 radioisotopic ages show that the oldest exposed South Sister lavas were initially rhyolitic ~50ka. By ~37ka, rhyolitic lava flows and domes (72-74% SiO2) began alternating with radially emplaced dacite (63-68% SiO2) and andesite (59-63% SiO2) lava flows. Construction of a broad cone of silicic andesite-dacite (61-64% SiO2) culminated ~30ka in a dominantly explosive sequence that began with crater-forming andesitic eruptions that left fragmental deposits at least 200m thick. This was followed at ~27ka by growth of a steeply dipping summit cone of agglutinate-dominated andesite (56-60.5% SiO2) and formation of a summit crater ~800m wide. This crater was soon filled and overtopped by a thick dacite lava flow and then by >150m of dacitic pyroclastic ejecta. Small-volume dacite lavas (63-67% SiO2) locally cap the pyroclastic pile. A final sheet of mafic agglutinate (54-56% SiO2) - the most mafic product of South Sister - erupted from and drapes the small (300-m-wide) present-day summit crater, ending a summit-building sequence that lasted until ~22ka. A 20kyr-long-hiatus was broken by rhyolite eruptions that produced (1) the Rock Mesa coulee, tephra, and satellite domelets (73.5% SiO2) and (2) the Devils Chain of ~20 domes and short coulees (72.3-72.8% SiO2) from N-S vent alignments on South Sister's flanks. The compositional reversal from mafic summit agglutinate to recent rhyolites epitomizes the frequently changing compositional modes of the

  17. [Two Dutch sisters in analysis with Freud].

    PubMed

    Stroeken, Harry

    2010-01-01

    The author provides persuasive or at least plausible data for the identity of two patients recorded by Freud in his working season of 1910/11. They were two sisters, living in The Hague/Leiden, who came from a rich banker's family, the van der Lindens. Whereas the treatment does not seem to have led to any decisive improvement for the older of the two, it may have encouraged the younger sister to seek divorce. PMID:20503771

  18. Flow behavior in the Wright Brothers Facility

    NASA Technical Reports Server (NTRS)

    Genn, S.

    1984-01-01

    It has become increasingly apparent that a reexamination of the flow characteristics in the low speed Wright Brothers Facility (WBF) is of some importance in view of recent improvements in the precision of the data acquisition system. In particular, the existence of local regions of separation, if any, in back portions of the circuit, and possible related unsteadiness, are of interest. Observations from that initial experiment did indicate some unsteady air flow problems in the cross leg, and thereafter the test region (Section A) was calibrated quantitatively. The intent was to learn something about the effect of upstream intermittent behavior flow on the test section flow, as well as to provide an extensive calibration as a standard for the effects induced by future alteration of the tunnel. Distributions of total pressure coefficients were measured first at one cross-section plane of the test section, namely the model station. Data were obtained for several tunnel speeds. The reduced data yielded an unexpected distribution involving larger pressures along the inside wall.

  19. The Lehman Brothers effect and bankruptcy cascades

    NASA Astrophysics Data System (ADS)

    Sieczka, P.; Sornette, D.; Holyst, J. A.

    2011-08-01

    Inspired by the bankruptcy of Lehman Brothers and its consequences on the global financial system, we develop a simple model in which the Lehman default event is quantified as having an almost immediate effect in worsening the credit worthiness of all financial institutions in the economic network. In our stylized description, all properties of a given firm are captured by its effective credit rating, which follows a simple dynamics of co-evolution with the credit ratings of the other firms in our economic network. The dynamics resembles the evolution of Potts spin-glass with external global field corresponding to a panic effect in the economy. The existence of a global phase transition, between paramagnetic and ferromagnetic phases, explains the large susceptibility of the system to negative shocks. We show that bailing out the first few defaulting firms does not solve the problem, but does have the effect of alleviating considerably the global shock, as measured by the fraction of firms that are not defaulting as a consequence. This beneficial effect is the counterpart of the large vulnerability of the system of coupled firms, which are both the direct consequences of the collective self-organized endogenous behaviors of the credit ratings of the firms in our economic network.

  20. The Impact of Siblings with Disabilities on Their Brothers and Sisters Pursuing a Career in Special Education

    ERIC Educational Resources Information Center

    Marks, Susan Unok; Matson, Amy; Barraza, Lori

    2005-01-01

    It is well known that growing up with a sibling who has a disability has both positive and negative impacts on the non-disabled sibling (Beckman, 2002; Fisman, Wolf, Ellison, & Freeman, 2000; Gans, 1997; McHugh, 2003). In fact, the concern for ameliorating the potential negative impacts on nondisabled siblings has been a major impetus for the…

  1. Biological versus nonbiological older brothers and men's sexual orientation.

    PubMed

    Bogaert, Anthony F

    2006-07-11

    The most consistent biodemographic correlate of sexual orientation in men is the number of older brothers (fraternal birth order). The mechanism underlying this effect remains unknown. In this article, I provide a direct test pitting prenatal against postnatal (e.g., social/rearing) mechanisms. Four samples of homosexual and heterosexual men (total n = 944), including one sample of men raised in nonbiological and blended families (e.g., raised with half- or step-siblings or as adoptees) were studied. Only biological older brothers, and not any other sibling characteristic, including nonbiological older brothers, predicted men's sexual orientation, regardless of the amount of time reared with these siblings. These results strongly suggest a prenatal origin to the fraternal birth-order effect. PMID:16807297

  2. [Letterer-Siwe disease in half-brothers].

    PubMed

    Pribluda, B A

    1986-01-01

    Letterer-Siwe disease is reported in half-brothers, 15 and 11 months old, with a duration of the disease about 2 and 1 month. A similar clinical picture manifested by hyperthermia, hepatosplenomegaly, moderate lymphadenopathy, cutaneous changes in one of the brothers, increasing hypochromic anemia, thrombocytopenia, as well as similar morphologic changes (marked histiocytic infiltration of the viscera, hemorrhages, necroses, neoplastic changes in the liver and lungs of one boy) allowed differentiation of familial hemophagocytic histiocytosis from Letterer-Siwe disease in one family. PMID:3827626

  3. SISTER CHROMATID EXCHANGES IN MAMMALIAN MEIOTIC CHROMOSOMES

    EPA Science Inventory

    Very little is known about sister chromatid exchanges (SCEs) in meiotic cells--only that they occur (1) and reveal frequency and distribution patterns apparently unaffected by cross-over (CO) exchange conditions in those cells; (2) unfortunately, the number of studies from which ...

  4. Sisters at Work: Career and Community Changes.

    ERIC Educational Resources Information Center

    Briody, Elizabeth K.; Sullivan, Teresa A.

    1988-01-01

    The authors examine occupational differentiation of U.S. Catholic nuns before and since the Second Vatican Council. Data were collected from interviews with 30 sisters representing 11 congregations. The analysis relates the diversification of their careers to changes in ideology and life-style and to the changing demographic and financial status…

  5. Older Brother's Influence on Younger Sibling's Drug Use.

    ERIC Educational Resources Information Center

    Brook, Judith S.; And Others

    1983-01-01

    Examines, in 339 ninth- and tenth-grade adolescents, the effect of the sibling relationship "having an older brother" on the younger sibling's stage of drug use, exploring sex differences in sibling effects. Sibling effects were examined in the context of the younger sibling's peer group. (Author/RH)

  6. Precalcaneal congenital fibrolipomatous hamartomas: report of occurrence in half brothers.

    PubMed

    Fangman, William L; Prose, Neil S

    2004-01-01

    Precalcaneal congenital fibrolipomatous hamartomas are uncommon, congenital, nontender papules located on the medial plantar aspects of the heel. We report the occurrence of this rare disorder in two half brothers, suggesting that it may occur in a familial pattern. PMID:15575850

  7. Propaganda in Warner Brothers World War II Cartoons.

    ERIC Educational Resources Information Center

    Machowski, James Stanley; Brown, James William

    To examine the role of the animated cartoon in propaganda associated with World War II, 194 of 262 cartoons produced for theatrical release by Warner Brothers, Inc., from 1939 to 1946 were analyzed. Propaganda content was determined by the number and nature of symbols used and the cartoon's "attitudes" toward these symbols. An analysis grid was…

  8. High Functioning Autism and Childhood Disintegrative Disorder in Half Brothers.

    ERIC Educational Resources Information Center

    Zwaigenbaum, L.; Szatmari, P.; Mahoney, W.; Bryson, S.; Bartolucci, G.; MacLean, J.

    2000-01-01

    This case report describes the presence of autism and Childhood Disintegrative Disorder (CDD) cosegregating within a sibship of half-brothers with the same mother. The report suggests that the rarity of the two conditions suggests a shared transmissible mechanism. (Contains references.) (Author/DB)

  9. Priests, Brothers, and the Religion and Stress Questionnaire.

    ERIC Educational Resources Information Center

    Rayburn, Carole A.; And Others

    Clergymen have been facing new challenges and stresses resulting from greater numbers of women entering seminaries and positions of religious leadership. In this study, 54 Roman Catholic priests and 50 brothers were given the specially devised Religion and Stress Questionnaire to explore their sensitivity towards some of the gender issues…

  10. Crocodile Talk: Attributions of Incestuously Abused and Nonabused Sisters.

    ERIC Educational Resources Information Center

    Monahan, Kathleen

    1997-01-01

    This qualitative study analyzed the retrospective attributions of adult sisters (five abused sister dyads, and five abused and nonabused sister dyads) who grew up in incestuous families. It examined the attributions of subjects regarding the general sibling group; victim selection and nonselection; and attributions regarding jealousy, protection,…

  11. The Lay Sister in Educational History and Memory.

    ERIC Educational Resources Information Center

    Jack, Christine Trimingham

    2000-01-01

    Focuses on the construction of lay sisters in a religious order and school setting using a poststructuralist orientation. Explains that in the study documents were examined and interviews were conducted with ex-students, choir nuns, and a lay sister at a small Catholic girls-preparatory boarding school. Explores the narrative of one lay sister.…

  12. 77 FR 13585 - Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-07

    ... COMMISSION Three Sisters Irrigation District; Notice of Application Accepted for Filing and Soliciting..., 2012. d. Applicant: Three Sisters Irrigation District. e. Name of Project: Three Sisters Irrigation District Hydroelectric Project. f. Location: The proposed Three Sisters Irrigation District...

  13. Big Surveys, Big Data Centres

    NASA Astrophysics Data System (ADS)

    Schade, D.

    2016-06-01

    Well-designed astronomical surveys are powerful and have consistently been keystones of scientific progress. The Byurakan Surveys using a Schmidt telescope with an objective prism produced a list of about 3000 UV-excess Markarian galaxies but these objects have stimulated an enormous amount of further study and appear in over 16,000 publications. The CFHT Legacy Surveys used a wide-field imager to cover thousands of square degrees and those surveys are mentioned in over 1100 publications since 2002. Both ground and space-based astronomy have been increasing their investments in survey work. Survey instrumentation strives toward fair samples and large sky coverage and therefore strives to produce massive datasets. Thus we are faced with the "big data" problem in astronomy. Survey datasets require specialized approaches to data management. Big data places additional challenging requirements for data management. If the term "big data" is defined as data collections that are too large to move then there are profound implications for the infrastructure that supports big data science. The current model of data centres is obsolete. In the era of big data the central problem is how to create architectures that effectively manage the relationship between data collections, networks, processing capabilities, and software, given the science requirements of the projects that need to be executed. A stand alone data silo cannot support big data science. I'll describe the current efforts of the Canadian community to deal with this situation and our successes and failures. I'll talk about how we are planning in the next decade to try to create a workable and adaptable solution to support big data science.

  14. Big bluestem

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Big Bluestem (Andropogon gerardii) is a warm season grass native to North America, accounting for 40% of the herbaceous biomass of the tall grass prairie, and a candidate for bioenergy feedstock production. The goal of this study was to measure among and within population genetic variation of natura...

  15. Big Dreams

    ERIC Educational Resources Information Center

    Benson, Michael T.

    2015-01-01

    The Keen Johnson Building is symbolic of Eastern Kentucky University's historic role as a School of Opportunity. It is a place that has inspired generations of students, many from disadvantaged backgrounds, to dream big dreams. The construction of the Keen Johnson Building was inspired by a desire to create a student union facility that would not…

  16. Big Opportunities and Big Concerns of Big Data in Education

    ERIC Educational Resources Information Center

    Wang, Yinying

    2016-01-01

    Against the backdrop of the ever-increasing influx of big data, this article examines the opportunities and concerns over big data in education. Specifically, this article first introduces big data, followed by delineating the potential opportunities of using big data in education in two areas: learning analytics and educational policy. Then, the…

  17. Coloured sweat in two brothers: First report of familial chromhidrosis.

    PubMed

    Gaffney, Daniel C; Cooper, Hywel L

    2016-02-01

    The uncommon diagnosis of chromhidrosis is most frequently made in young adults. This sweat gland disease, although benign, may impact significantly on the patient's quality of life. We describe the first report of familial chromhidrosis of pseudo-eccrine type (pseudochromhidrosis) occurring in two brothers aged 9 and 12 years. The classification and causality of chromhidrosis is described and approaches to assessment and management are outlined. PMID:25753446

  18. George Orwell and Modern Science Fiction: The Legacy of Big Brother.

    ERIC Educational Resources Information Center

    Lerner, Fred

    1984-01-01

    Discusses George Orwell's lack of influence on modern science fiction and presents a selected annotated bibliography of modern science fiction materials depicting a wide variety of totalitarian societies. (MBR)

  19. Big Brother and the National Reading Curriculum: How Ideology Trumped Evidence.

    ERIC Educational Resources Information Center

    Allington, Richard

    This book about reading tracks and questions the 30-year campaign that has focused on testing, accountability, and federalization of education to demonstrate that it is not just whole language advocates who are having problems with the National Reading Panel report and the new education laws. The book gathers together a comprehensive collection of…

  20. Big brother - a fully automated control system for the DELPHI experiment

    SciTech Connect

    Franek, B.; Sekulin, R.; Doenszelmann, M.; Gasper, C.; Charpentier, Jonker, M.

    1994-12-31

    The integrated control system of the DELPHI experiment is described. It allows the data to be taken in an almost automatic fashion. This is achieved by computer monitoring of the states of the LEP machine, the DELPHI subdetectors (SC) and the Data Acquisition System (DAS). Depending on these states, computer initiated actions are then taken. It has been designed using {open_quote}State Manager{close_quote} concept already used for local and central controls of DAS and SC.

  1. Colleges Fear Anti-Terrorism Law Could Turn Them into Big Brother.

    ERIC Educational Resources Information Center

    Carlson, Scott; Foster, Andrea L.

    2002-01-01

    Describes how many college officials are confused by the USA Patriot Act, a new anti-terrorism law that may affect campus networks and library records; they believe its provisions could raise privacy and academic freedom issues. (EV)

  2. Brown and polar bear Y chromosomes reveal extensive male-biased gene flow within brother lineages.

    PubMed

    Bidon, Tobias; Janke, Axel; Fain, Steven R; Eiken, Hans Geir; Hagen, Snorre B; Saarma, Urmas; Hallström, Björn M; Lecomte, Nicolas; Hailer, Frank

    2014-06-01

    Brown and polar bears have become prominent examples in phylogeography, but previous phylogeographic studies relied largely on maternally inherited mitochondrial DNA (mtDNA) or were geographically restricted. The male-specific Y chromosome, a natural counterpart to mtDNA, has remained underexplored. Although this paternally inherited chromosome is indispensable for comprehensive analyses of phylogeographic patterns, technical difficulties and low variability have hampered its application in most mammals. We developed 13 novel Y-chromosomal sequence and microsatellite markers from the polar bear genome and screened these in a broad geographic sample of 130 brown and polar bears. We also analyzed a 390-kb-long Y-chromosomal scaffold using sequencing data from published male ursine genomes. Y chromosome evidence support the emerging understanding that brown and polar bears started to diverge no later than the Middle Pleistocene. Contrary to mtDNA patterns, we found 1) brown and polar bears to be reciprocally monophyletic sister (or rather brother) lineages, without signals of introgression, 2) male-biased gene flow across continents and on phylogeographic time scales, and 3) male dispersal that links the Alaskan ABC islands population to mainland brown bears. Due to female philopatry, mtDNA provides a highly structured estimate of population differentiation, while male-biased gene flow is a homogenizing force for nuclear genetic variation. Our findings highlight the importance of analyzing both maternally and paternally inherited loci for a comprehensive view of phylogeographic history, and that mtDNA-based phylogeographic studies of many mammals should be reevaluated. Recent advances in sequencing technology render the analysis of Y-chromosomal variation feasible, even in nonmodel organisms. PMID:24667925

  3. Sister Mary Emil Penet, I.H.M.: Founder of the Sister Formation Conference

    ERIC Educational Resources Information Center

    Glisky, Joan

    2006-01-01

    Mary Emil Penet, I.H.M., (1916-2001) used her talents and charisma to shape the first national organization of American women religious, the Sister Formation Conference (SFC; 1954-1964), facilitating the integrated intellectual, spiritual, psychological, and professional development of vowed women religious. In the decade preceding Vatican II, her…

  4. Bardet-Biedl syndrome in two sisters: A rare incidence

    PubMed Central

    Varma, Chaitanya; Bhat, Ramesh Y.; Bhatt, Sonia

    2013-01-01

    Bardet-Biedl syndrome is an autosomal recessive disorder characterized by retinitis pigmentosa, obesity, polydactyly, mental retardation and hypogonadism. We present two sisters with this rare genetic condition.

  5. Crocodile talk: attributions of incestuously abused and nonabused sisters.

    PubMed

    Monahan, K

    1997-01-01

    This study is a qualitative analysis of the attributions of sisters (abused and nonabused sister dyads, n = 10 and abused sister dyads, n = 10) who grew up in an incestuous family. While the sibling subsystem is reported to be the most important and enduring relational environment in the life of the family, little is known about the cognitions and attributions of siblings, regarding incest. This study examines the attributions of participants regarding the general sibling group, victim selection and nonselection, as well as attributions regarding jealousy, protection, and guilt within the sister relationship. PMID:9023020

  6. An incest case with three biological brothers as alleged fathers: Even 22 autosomal STR loci analysis would not suffice without the mother.

    PubMed

    Canturk, Kemal Murat; Emre, Ramazan; Gurkan, Cemal; Komur, Ilhami; Muslumanoglu, Omer; Dogan, Muhammed

    2016-07-01

    Here, we report an incest paternity case involving three biological brothers as alleged fathers (AFs), their biological sister and her child that was investigated using the Investigator ESSplex Plus, AmpFLSTR Identifiler Plus/Investigator IDplex Plus and PowerPlex 16 kits. Initial duo paternity investigations using 15-loci autosomal short tandem repeat (STR) analyses failed to exclude any of the AFs. Despite the fact that one of the brothers, AF1, had a mismatch with the child at a single locus (D2S1338), the possibility of a single-step mutation could not be ruled out. When the number of autosomal STR loci analysed was increased to 22 without the inclusion of the mother, AF2 and AF3 still could not be excluded, since both of them again had no mismatches with the child. A breakthrough was possible only upon inclusion of the mother so that trio paternity investigations were carried out. This time AF1 and AF2 could be excluded at two loci (D2S1338 and D1S1656) and six loci (vWa, D1S1656, D12S391, FGA, PENTA E and PENTA D), respectively, and AF3 was then the only brother who could not be excluded from paternity. Subsequent statistical analyses suggested that AF3 could be the biological father of the child with a combined paternity index >100 billion and a probability of paternity >99.99999999%. These findings consolidate the fact that complex paternity cases such as those involving incest could benefit more from the inclusion of the mother than simply increasing the number of STR loci analysed. PMID:26377934

  7. Big Bang, Big Data, Big Computers

    NASA Astrophysics Data System (ADS)

    Conference website: http://www.apc.univ-paris7.fr/APC/Conferences/Workshop_Big3/Home.html Observations of the Cosmic Microwave Background (CMB) radiation have transformed modern cosmology propelling it into high-precision, data-driven science it is today. CMB data analysis has been a cornerstone of this transformation and it continues in this role preparing currently to meet its possibly ultimate challenge as posed by ever-growing in size and complexity forthcoming data sets required by new science goals posed for the field. These include providing key pieces of information about the very early Universe: Gaussianity of the initial conditions, the presence of the primordial gravity waves, as well as constraints on the large-scale structure formation and possibly properties of dark energy. The sophistication of the involved data models is matched by precision levels, which have to be attained to deliver robust detections and result in firm conclusions. The overall challenge is indeed breathtaking and, without a doubt, the success will be only possible if the data analysis effort becomes truly interdisciplinary and capitalizes on the latest advances in statistics, applied mathematics, and computer science - all of which constitute veritable foundations of the contemporary data analysis work.

  8. EarthLabs Meet Sister Corita Kent

    NASA Astrophysics Data System (ADS)

    Quartini, E.; Ellins, K. K.; Cavitte, M. G.; Thirumalai, K.; Ledley, T. S.; Haddad, N.; Lynds, S. E.

    2013-12-01

    The EarthLabs project provides a framework to enhance high school students' climate literacy and awareness of climate change. The project provides climate science curriculum and teacher professional development, followed by research on students' learning as teachers implement EarthLabs climate modules in the classroom. The professional development targets high school teachers whose professional growth is structured around exposure to current climate science research, data observation collection and analysis. During summer workshops in Texas and Mississippi, teachers work through the laboratories, experiments, and hand-on activities developed for their students. In summer 2013, three graduate students from the University of Texas at Austin Institute for Geophysics with expertise in climate science participated in two weeklong workshops. The graduate students partnered with exemplary teacher leaders to provide scientific content and lead the EarthLabs learning activities. As an experiment, we integrated a visit to the Blanton Museum and an associated activity in order to motivate participants to think creatively, as well as analytically, about science. This exercise was inspired by the work and educational philosophy of Sister Corita Kent. During the visit to the Blanton Museum, we steered participants towards specific works of art pre-selected to emphasize aspects of the climate of Texas and to draw participants' attention to ways in which artists convey different concepts. For example, artists use of color, lines, and symbols conjure emotional responses to imagery in the viewer. The second part of the exercise asked participants to choose a climate message and to convey this through a collage. We encouraged participants to combine their experience at the museum with examples of Sister Corita Kent's artwork. We gave them simple guidelines for the project based on techniques and teaching of Sister Corita Kent. Evaluation results reveal that participants enjoyed the

  9. Building International Relations for Children through Sister Schools.

    ERIC Educational Resources Information Center

    Pryor, Carolyn B.

    1992-01-01

    Inspired by Sister Cities International and the NASSP's school-to-school exchange program, "sister school" pairings have proved to be workable educational programs with long-range impact on participants. Some post-cold war efforts include U.S.-USSR High School Academic Partnerships, Project Harmony, and Center for U.S.-USSR Initiatives. Resource…

  10. [Concordant deuteranomaly in monozygotic twin sisters (author's transl)].

    PubMed

    Franceschetti, A T; Klein, D; Dieterle, P

    1976-12-01

    Colorblind twin sisters were born from the marriage of a hemizygote with a carrier for colorblindness. The proof of monozygosity is given by the blood-group typing and the dermatoglyphs. The deuteranomaly is of the same degree in each but is more marked in one of the sisters. The mother has none of the microsymptoms sometimes found in carriers. PMID:1088162

  11. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 4 2014-10-01 2014-10-01 false Plans for sister vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for sister vessels. (a) Plans are not required for a vessel that is a...

  12. 46 CFR 116.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 4 2012-10-01 2012-10-01 false Plans for sister vessels. 116.210 Section 116.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS CARRYING MORE... ARRANGEMENT Plans § 116.210 Plans for sister vessels. (a) Plans are not required for a vessel that is a...

  13. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  14. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  15. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 7 2011-10-01 2011-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  16. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 7 2014-10-01 2014-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  17. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  18. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 7 2012-10-01 2012-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  19. 46 CFR 169.307 - Plans for sister vessels.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 7 2013-10-01 2013-10-01 false Plans for sister vessels. 169.307 Section 169.307 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) NAUTICAL SCHOOLS SAILING SCHOOL VESSELS Construction and Arrangement Plans § 169.307 Plans for sister vessels. Plans are not required for any...

  20. 46 CFR 177.210 - Plans for sister vessels.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 7 2010-10-01 2010-10-01 false Plans for sister vessels. 177.210 Section 177.210 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) SMALL PASSENGER VESSELS (UNDER 100 GROSS TONS) CONSTRUCTION AND ARRANGEMENT Plans § 177.210 Plans for sister vessels. (a) Plans are not...

  1. Identical male twins and brother with Cockayne syndrome.

    PubMed

    Houston, C S; Zaleski, W A; Rozdilsky, B

    1982-10-01

    The clinical, radiological, and neuropathological findings in early onset Cockayne syndrome are illustrated in identical twins and their brother. Their appearance of dwarfism with small head and prominent beaked nose strongly resembled that seen in the Seckel syndrome, but unlike patients with that syndrome they had a normal birth weight (for twins), thick cranial vaults, intracranial calcification, and a severe degree of mental retardation. The twins were deaf and blind, with optic atrophy and retinal pigmentation, while their brother had cataracts. Their hands and feet were large in proportion to their small trunk. They had cutaneous sensitivity to any slight exposure to ultraviolet light and severe neurologic problems with incoordination and spasticity. Radiologic findings included microcephaly, a thick cranial vault, a small pelvis, coxa valga, and "ivory epiphyses" in terminal phalanges of hands and feet. Pathologic findings included atrophy of white matter with widespread patchy demyelination, and massive siderocalcific deposits in the brain, particularly in the basal ganglia and cerebellum. While autosomal recessive inheritance is most likely, formally X-linked inheritance cannot be excluded. PMID:6890311

  2. Matching osteochondritis dissecans lesions in identical twin brothers.

    PubMed

    Richie, Lucas B; Sytsma, Mark J

    2013-09-01

    Osteochondritis dissecans is a disorder of unknown etiology that can result in fragmentation of osteochondral surfaces, most commonly of the knee, shoulder, elbow, and ankle. This may lead to sequelae of pain and an inability to participate in desired activities. Multiple theories exist as to the true cause of the disorder, but none have been fully proven. One such proposed etiology is genetic causation. Familial cases of osteochondritis dissecans are rare, yet these cases offer support to growing evidence that may support a genetic link. This article describes osteochondritis dissecans lesions of the femoral trochlea in monozygotic (identical) twins. Both twins presented with similar symptoms 1 year apart. Neither twin had any clear inciting trauma. Magnetic resonance imaging revealed osteochondral lesions in similar positions of the lateral trochlear of the same knee in both brothers. Osteochondral autograft transfer and tibial tubercle anteromedialization were performed on both patients. An identical postoperative protocol was followed, and recovery with full return to sport was comparable for the brothers. To the authors' knowledge, only 1 other case report exists of osteochondritis dissecans lesions in monozygotic twins. Although debate continues regarding the true etiology of this disorder, cases of identical twins presenting with a similar disease process are highly suggestive of a genetic component and may lead to early identification and treatment of these lesions. Continued research in the area of osteochondritis dissecans and its genetic basis is needed to completely understand this disorder. PMID:24025016

  3. Brief Functional Analysis and Simplified Habit Reversal Treatment of Thumb Sucking in Fraternal Twin Brothers.

    ERIC Educational Resources Information Center

    Rapp, John T.; Miltenberger, Raymond G.; Galensky, Tami L.; Roberts, Jennifer; Ellington, Sherry A.

    1999-01-01

    Utilizes functional analysis to evaluate the thumb sucking of fraternal twin brothers. Results suggest that thumb sucking for one brother was maintained by automatic reinforcement; this was suppressed by simplified habit reversal components of awareness training, competing response training, and social support. Thumb sucking for the second brother…

  4. Gliding Experiments of the Wright Brothers: Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Cole, Jennifer Hansen; Martin, John Campbell

    2011-01-01

    Presentation showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905, Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  5. Continuity & Change in Catholic Education: An Ethnography of Christian Brothers College. Research Monograph No. 1.

    ERIC Educational Resources Information Center

    Bates, Richard; And Others

    Four papers on an ethnographic study of Christian Brothers College (CBC) in Australia, a Catholic college, are presented. In "Christian Brothers College: A View from Overseas," Louis M. Smith discusses research methods, the religious ethos, faculty heterogeneity, diversity in classroom organization, the organizational context of the college, and…

  6. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Albion H.; Hansen, Jennifer; Martin, Cam

    2007-01-01

    Viewgraphs showing glider experiments of the Wright Brothers from 1899-1908 are presented. The slides review the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  7. 3 CFR 8617 - Proclamation 8617 of December 17, 2010. Wright Brothers Day, 2010

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 3 The President 1 2011-01-01 2011-01-01 false Proclamation 8617 of December 17, 2010. Wright Brothers Day, 2010 8617 Proclamation 8617 Presidential Documents Proclamations Proclamation 8617 of December 17, 2010 Proc. 8617 Wright Brothers Day, 2010By the President of the United States of America A Proclamation On December 17, 1903, after years...

  8. 3 CFR 8767 - Proclamation 8767 of December 15, 2011. Wright Brothers Day, 2011

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 3 The President 1 2012-01-01 2012-01-01 false Proclamation 8767 of December 15, 2011. Wright Brothers Day, 2011 8767 Proclamation 8767 Presidential Documents Proclamations Proclamation 8767 of December 15, 2011 Proc. 8767 Wright Brothers Day, 2011By the President of the United States of America A Proclamation On a blustery December morning...

  9. Creating Sister Cities: An Exchange Across Hemispheres

    NASA Astrophysics Data System (ADS)

    Adams, M. T.; Cabezon, S. A.; Hardy, E.; Harrison, R. J.

    2008-06-01

    Sponsored by Associated Universities, Inc. (AUI) and the National Radio Astronomy Observatory (NRAO), this project creates a cultural and educational exchange program between communities in South and North America, linking San Pedro de Atacama in Chile and Magdalena, New Mexico in the United States. Both communities have similar demographics, are in relatively undeveloped regions of high-elevation desert, and are located near major international radio astronomy research facilities. The Atacama Large Millimeter/submillimeter Array (ALMA) is just 40 km east of San Pedro; the Very Large Array (VLA) is just 40 km west of Magdalena. In February 2007, the Mayor of San Pedro and two teachers visited Magdalena for two weeks; in July 2007 three teachers from Magdalena will visit San Pedro. These visits enable the communities to lay the foundation for a permanent, unique partnership. The teachers are sharing expertise and teaching methodologies for physics and astronomy. In addition to creating science education opportunities, this project offers students linguistic and cultural connections. The town of San Pedro, Chile, hosts nearly 100,000 tourists per year, and English language skills are highly valued by local students. Through exchanges enabled by email and distance conferencing, San Pedro and Magdalena students will improve English and Spanish language skills while teaching each other about science and their respective cultures. This poster describes the AUI/NRAO Sister Cities program, including the challenges of cross-cultural communication and the rewards of interpersonal exchanges between continents and cultures.

  10. Horsetails are the sister group to all other monilophytes and Marattiales are sister to leptosporangiate ferns.

    PubMed

    Knie, Nils; Fischer, Simon; Grewe, Felix; Polsakiewicz, Monika; Knoop, Volker

    2015-09-01

    The "Monilophyte" clade comprising ferns, horsetails and whisk ferns receives unequivocal support from molecular data as the sister clade to seed plants. However, the branching order of its earliest emerging lineages, the Equisetales (horsetails), the Marattiales, the Ophioglossales/Psilotales and the large group of leptosporangiate ferns has remained dubious. We investigated the mitochondrial nad2 and rpl2 genes as two new, intron-containing loci for a wide sampling of taxa. We found that both group II introns - nad2i542g2 and rpl2i846g2 - are universally present among monilophytes. Both introns have orthologues in seed plants where nad2i542g2 has evolved into a trans-arrangement. In contrast and despite substantial size extensions to more than 5kb in Psilotum, nad2i542g2 remains cis-arranged in the monilophytes. For phylogenetic analyses, we filled taxonomic gaps in previously investigated mitochondrial (atp1, nad5) and chloroplast (atpA, atpB, matK, rbcL, rps4) loci and created a 9-gene matrix that also included the new mitochondrial nad2 and rpl2 loci. We extended the taxon sampling with two taxa each for all land plant outgroups (liverworts, mosses, hornworts, lycophytes and seed plants) to minimize the risk of phylogenetic artefacts. We ultimately obtained a well-supported molecular phylogeny placing Marattiales as sister to leptosporangiate ferns and horsetails as sister to all remaining monilophytes. In addition, an indel in an exon of the here introduced rpl2 locus independently supports the placement of horsetails. We conclude that under dense taxon sampling, phylogenetic information from a prudent choice of loci is currently superior to character-rich phylogenomic approaches at low taxon sampling. As here shown the selective choice of loci and taxa enabled us to resolve the long-enigmatic diversifications of the earliest monilophyte lineages. PMID:25999055

  11. 38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    38. 8 sisters and powerhouse, pulverizer building for powerhouse, coal conveyor, blast stoves, "A" furnace, stoves, "B" furnace, stoves, "C" furnace, bottle cars. Looking south - Rouge Steel Company, 3001 Miller Road, Dearborn, MI

  12. 8. STREAMSIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    8. STREAM-SIDE PATH NEAR MIDDLE OF THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

  13. How-to-Do-It: Demonstrating Sister Chromatid Exchanges.

    ERIC Educational Resources Information Center

    Dye, Frank J.

    1988-01-01

    Outlines procedures for demonstrating and preparing a permanent slide of sister chromatid exchanges and recombination events between the two chromatids of a single chromosome. Provides the name of an additional resource for making preparations of exchanges. (RT)

  14. UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    UNDERSIDE FROM SOUTH BANKS; NOTICE NEW GLUE LAM CROSSBEAMS SISTERED TO OLDER BEAMS, NEW STRINGERS AND COMPONENTS MAKE UP A NEARLY NEW SUPPORT SYSTEM - Short Bridge, Spanning South Santiam River at High Deck Road, Cascadia, Linn County, OR

  15. Sister chromatid decatenation: bridging the gaps in our knowledge

    PubMed Central

    Broderick, Ronan; Niedzwiedz, Wojciech

    2015-01-01

    Faithful chromosome segregation is critical in preventing genome loss or damage during cell division. Failure to properly disentangle catenated sister chromatids can lead to the formation of bulky or ultrafine anaphase bridges, and ultimately genome instability. In this review we present an overview of the current state of knowledge of how sister chromatid decatenation is carried out, with particular focus on the role of TOP2A and TOPBP1 in this process. PMID:26266709

  16. Cholangicarcinoma Presenting as a Sister Mary Joseph Nodule

    PubMed Central

    Rangegowda, Devaraja; Vyas, Tanmay; Grover, Shrruti; Joshi, YK; Sharma, Chhagan; Sahney, Amrish

    2016-01-01

    Sister Mary Joseph nodules represent metastatic cancer of the umbilicus. More than half of these cases are attributable to gastrointestinal malignancies including gastric, colonic, and pancreatic cancer. In addition, gynecologic (ovarian, uterine cancer), unknown primary tumors, and, rarely, bladder or respiratory malignancies may cause umbilical metastasis. We report the case of a Sister Mary Joseph nodule originating from a hilar cholangiocarcinoma. Umbilical nodules should prompt clinical evaluation, as these tumors are usually associated with poor prognosis. PMID:27144207

  17. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2008-01-01

    This viewgraph presentation reviews the Wright Brothers's flight research during the 10 years between 1899 and 1908. The Wright Brothers began their research in flight with gliders. The presentation shows pictures, replicas and characteristics of the gliders that the Wright Brothers used. This presentation is not just a history lesson. In the end it investigates "What Does Flight Research Accomplish?" Flight research can serve many uses, such as Separates the Real from the Imagined, Uncovers the Unexpected and the Overlooked, Forces the Realistic Integration of the Pilot, Forces the Development of Reliable Prediction and Test Processes, Requires Every Problem to Be Addressed, Promotes Technology Transfer, and Builds a Core Technical Team,

  18. Doing What Your Big Sister Does: Sex, Postfeminism and the YA Chick Lit Series

    ERIC Educational Resources Information Center

    Bullen, Elizabeth; Toffoletti, Kim; Parsons, Liz

    2011-01-01

    Mass-marketed teen chick lit has become a publishing phenomenon and has begun to attract critical interest among children's literature scholars. Much of this critical work, however, has shied away from robust critical assessment of the postfeminist conditions informing the production and reception of young adult series like Private, Gossip Girl…

  19. The identification and characterization of human Sister-of-Mammalian Grainyhead (SOM) expands the grainyhead-like family of developmental transcription factors.

    PubMed Central

    Ting, Stephen B; Wilanowski, Tomasz; Cerruti, Loretta; Zhao, Lin-Lin; Cunningham, John M; Jane, Stephen M

    2003-01-01

    The Drosophila gene grainyhead is the founding member of a large family of genes encoding developmental transcription factors that are highly conserved from fly to human. The family consists of two main branches, with grainyhead as the ancestral gene for one branch and the recently cloned Drosophila CP2 as the ancestral gene for the other. We now extend this family with the identification of another novel mammalian member, Sister-of-Mammalian Grainyhead (SOM), which is phylogenetically aligned with grainyhead. SOM is closely related to the other mammalian homologues of grainyhead, including Mammalian Grainyhead (MGR) and Brother-of-MGR, sharing a high degree of sequence identity with these factors in the functional DNA-binding, protein dimerization and activation domains. Protein interaction studies demonstrate that SOM can heterodimerize with MGR and Brother-of-MGR, but not with the more distant members of the family. Like grainyhead, the SOM gene too produces several distinct isoforms with differing functional properties through alternative splicing. The tissue distributions of these isoforms differ and all display highly restricted expression patterns. These findings indicate that SOM, like its family members, may play important roles in mammalian development. PMID:12549979

  20. [Discovery of a monoclonal gammopathy in 2 brothers and its classification by electroimmunodiffusion].

    PubMed

    Mari, S; Zepponi, E; Nardone, G; Milano, R; Guanciale, C; Ranieri, M

    1980-06-01

    In this work the finding of a monoclonal band in two brothers is communicated. The electroimmunoprecipitation has been used for the typification. This technique seemed to be simple, rapid and of immediate interpretation. PMID:6787654

  1. Dyke-davidoff-masson syndrome: cases of two brothers and literature review.

    PubMed

    Park, Kyung-Il; Chung, Jae-Myun; Kim, Ji-Young

    2014-06-01

    Dyke-Davidoff-Masson syndrome (DDMS) has cerebral hemiatrophy and compensatory ipsilateral skull thickening, and is manifested by recurrent seizures and hemiparesis. We present one case with typical DDMS, who had a brother suffering from epilepsy with mild imaging abnormality relevant to DDMS and similar seizure semiology. A 26-year-old man had a history of developmental delay, mental retardation, hemiparesis and recurrent seizures. His brother, 23-year-old man had also experienced recurrent seizures, but he had no neurological deficits. Older brother experienced focal motor seizures with/without secondary generalization. Sometimes, he noted an auditory aura. MRI demonstrated the hemispheric atrophy with the adjacent bony hypertrophy. The seizures of younger brother were mainly of the auditory type and the MRI showed mild hemispheric atrophy with hippocampal sclerosis without any bony change. Our sibling cases might have a familial predisposition and support the idea that clinical courses and radiological findings of DDMS are varied even within one family. PMID:24977128

  2. The Montgolfier Brothers and the Invention of Aviation

    NASA Astrophysics Data System (ADS)

    Moore, Charles B.

    The first hot air balloon ascension over Paris in September 1783 has been described so many times that it and its passengers—the sheep, the rooster, and the duck—have joined Benjamin Franklin and his kite in the folklore of our culture. Not so well known is the earlier history of ballooning; that the brothers Montgolfier had demonstrated their hot air balloons repeatedly for several months prior to the ascent over Paris; or that the physicist Charles, urged onward and financed by an enthusiast, Barthélemy Faujas de Saint-Fond, launched successfully the first fabric balloon filled with hydrogen over Paris more than 3 weeks prior to the memorable ascent of the sheep, and rooster, and the duck.For all of its well-documented detail, the book is readable and enjoyable. It is a well-written but complex book in which Professor Gillispie develops a number of subjects to recreate the era in perspective. The origins and the disposition of the Montgolfiers, the industry of the period, the idea of capturing heated air are all reported in detail. The attempts to obtain government funding and the promotional activities in Paris were forerunners of the modern techniques for obtaining support of research activities.

  3. GNE Myopathy in Turkish Sisters with a Novel Homozygous Mutation

    PubMed Central

    Diniz, Gulden; Secil, Yaprak; Ceylaner, Serdar; Tokucoglu, Figen; Türe, Sabiha; Celebisoy, Mehmet; İncesu, Tülay Kurt; Akhan, Galip

    2016-01-01

    Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results. In this study, we present two Turkish sisters with progressive myopathy and describe a novel mutation in the GNE gene. Both sisters had slightly higher levels of creatine kinase (CK) and muscle weakness. The older sister presented at 38 years of age with an inability to climb steps, weakness, and a steppage gait. Her younger sister was 36 years old and had similar symptoms. The first symptoms of the disorder were seen when the sisters were 30 and 34 years old, respectively. The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. Conclusion. Based on our literature survey, we believe that ours is the first confirmed case of primary GNE myopathy with a novel missense mutation in Turkey. These patients illustrate that the muscle biopsy is still an important method for the differential diagnosis of vacuolar myopathies in that the detection of inclusions is required for the definitive diagnosis. PMID:27298745

  4. GNE Myopathy in Turkish Sisters with a Novel Homozygous Mutation.

    PubMed

    Diniz, Gulden; Secil, Yaprak; Ceylaner, Serdar; Tokucoglu, Figen; Türe, Sabiha; Celebisoy, Mehmet; İncesu, Tülay Kurt; Akhan, Galip

    2016-01-01

    Background. Hereditary inclusion body myopathy is caused by biallelic defects in the GNE gene located on chromosome 9p13. It generally affects adults older than 20 years of age. Methods and Results. In this study, we present two Turkish sisters with progressive myopathy and describe a novel mutation in the GNE gene. Both sisters had slightly higher levels of creatine kinase (CK) and muscle weakness. The older sister presented at 38 years of age with an inability to climb steps, weakness, and a steppage gait. Her younger sister was 36 years old and had similar symptoms. The first symptoms of the disorder were seen when the sisters were 30 and 34 years old, respectively. The muscle biopsy showed primary myopathic features and presence of rimmed vacuoles. DNA analysis demonstrated the presence of previously unknown homozygous mutations [c.2152 G>A (p.A718T)] in the GNE genes. Conclusion. Based on our literature survey, we believe that ours is the first confirmed case of primary GNE myopathy with a novel missense mutation in Turkey. These patients illustrate that the muscle biopsy is still an important method for the differential diagnosis of vacuolar myopathies in that the detection of inclusions is required for the definitive diagnosis. PMID:27298745

  5. Five Big Ideas

    ERIC Educational Resources Information Center

    Morgan, Debbie

    2012-01-01

    Designing quality continuing professional development (CPD) for those teaching mathematics in primary schools is a challenge. If the CPD is to be built on the scaffold of five big ideas in mathematics, what might be these five big ideas? Might it just be a case of, if you tell me your five big ideas, then I'll tell you mine? Here, there is…

  6. Brother is high Sr/Y two-mica granite and sister is leucogranite: twin granites in the Northern Himalayan Gneiss Domes, southern Tibet

    NASA Astrophysics Data System (ADS)

    Zeng, L.; Gao, L.; Xie, K.

    2011-12-01

    Leucogranites in the Himalayan orogen is widely considered as the type example of crustal melts, which provides a probe to investigate the interplay among high-grade metamorphism, crustal anatexis, and tectonic transition in large-scale collisional belts. Whether the leucogranite was a daughter product from a more primitive granitic melt is an interesting question that deserves careful examination to address the above issue. We report a new suite of two-mica granite (TMG) and leucogranite (LG) in the Yardoi gneiss dome (YGD) in the easternmost of the Northern Himalayan Gneiss Domes (NHGD), south of the Yarlung-Tsangpo suture. SHRIMP and LA-ICP-MS zircon U/Pb dating show that TMG and LG formed at ~17.7 Ma to ~20.0 Ma and at ~17.1 Ma, respectively. Both suites of granite have high Na/K (>1.30) ratios. The TMGs are characterized by (1) high Sr (>450 ppm), low Rb (<95 ppm) and Y (<6 ppm), and high Sr/Y (>86) ratios; (2) no Eu anomalies; and (3) low initial 87Sr/86Sr ratios (<0.7098) and higher ɛNd (>-8.5) values. In contrast, the LGs have (1) lower Sr (<130 ppm) and higher Rb (92-130 ppm); (2) pronounced negative Eu anomalies with Eu/Eu*<0.55; and (3) relatively higher Sr (87Sr/86Sr(t) =0.7136-0.7148) and unradiogenic Nd (ɛNd(t)=-7.7~-11.1). These data demonstrate that these Mid-Miocene granites have major and trace element and radiogenic isotope compositions similar to those of >35 Ma granites, but significantly different from those granites of similar ages in the High Himalaya as well as in the NHGD. High Sr/Y and relatively unradiogenic Sr isotope compositions in the TMGs could be derived from partial melting of mafic materials formed during previous compressional thickening event which was triggered by the input of juvenile heat and material associated with the Miocene E-W extension. An AFC process (plagioclase fractional crystallization and contamination by crustal materials) could be a primary factor leading to the formation of these LGs. Concurrence of high Sr/Y granites and leucogranites in NHGD indicates that the Miocene rifting could have played an important but previously unrecognized role in producing the Himalayan leucogranite. Similarly, the ~43-44 Ma high Sr/Y two-mica granites were also accompanied by the formation of typical leucogranite. However, the Mid-Eocene suite was derived from melting of lower crustal mafic materials at overthickened crustal conditions. Concurrence of high Sr/Y granites and typical leucogranites in the NHGD demonstrates that leucogranites could be derived from more primitive granitic melts by AFC process.

  7. Brother-Sister Differences in the g Factor in Intelligence: Analysis of Full, Opposite-Sex Siblings from the NLSY1979

    ERIC Educational Resources Information Center

    Deary, Ian J.; Irwing, Paul; Der, Geoff; Bates, Timothy C.

    2007-01-01

    There is scientific and popular dispute about whether there are sex differences in cognitive abilities and whether they are relevant to the proportions of men and women who attain high-level achievements, such as Nobel Prizes. A recent meta-analysis (Lynn, R., and Irwing, P. (2004). Sex differences on the progressive matrices: a meta-analysis.…

  8. Do Brothers Affect Their Sisters' Chances to Graduate? An Analysis of Sibling Sex Composition Effects on Graduation from a University or a "Fachhochschule" in Germany

    ERIC Educational Resources Information Center

    Jacob, Marita

    2011-01-01

    In a recent paper on gender inequality in higher education Buchman and DiPrete (2006) assume that the decrease in the gender gap in college completion in the US can partly be explained by changes in the allocation of familial resources in favour of women. However, they do not test this hypothesis empirically. In this paper I examine the effects of…

  9. A Long Noncoding RNA Regulates Sister Chromatid Cohesion.

    PubMed

    Marchese, Francesco P; Grossi, Elena; Marín-Béjar, Oskar; Bharti, Sanjay Kumar; Raimondi, Ivan; González, Jovanna; Martínez-Herrera, Dannys Jorge; Athie, Alejandro; Amadoz, Alicia; Brosh, Robert M; Huarte, Maite

    2016-08-01

    Long noncoding RNAs (lncRNAs) are involved in diverse cellular processes through multiple mechanisms. Here, we describe a previously uncharacterized human lncRNA, CONCR (cohesion regulator noncoding RNA), that is transcriptionally activated by MYC and is upregulated in multiple cancer types. The expression of CONCR is cell cycle regulated, and it is required for cell-cycle progression and DNA replication. Moreover, cells depleted of CONCR show severe defects in sister chromatid cohesion, suggesting an essential role for CONCR in cohesion establishment during cell division. CONCR interacts with and regulates the activity of DDX11, a DNA-dependent ATPase and helicase involved in DNA replication and sister chromatid cohesion. These findings unveil a direct role for an lncRNA in the establishment of sister chromatid cohesion by modulating DDX11 enzymatic activity. PMID:27477908

  10. Catholic sister nurses in Selma, Alabama, 1940-1972.

    PubMed

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters' work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  11. Improving patient flow: role of the orthopaedic discharge sister.

    PubMed

    Tytler, Beverley

    2016-03-01

    Timely and well-planned discharge improves the patient's experience, contributes to patient safety and reduces the length of hospital stays. The role of orthopaedic discharge sister was developed at James Cook University Hospital in 2007 to provide safe, timely and efficient discharge for patients from the trauma and theatre centre, and to improve patient experience and flow. This article gives an overview of the role and describes how the sister works with colleagues to plan patient discharges from pre-assessment and emergency department admission through their hospital stay until their departure. PMID:26948225

  12. Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres.

    PubMed

    Blattner, Ariane C; Chaurasia, Soumya; McKee, Bruce D; Lehner, Christian F

    2016-04-01

    Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase. PMID:27120695

  13. Separase Is Required for Homolog and Sister Disjunction during Drosophila melanogaster Male Meiosis, but Not for Biorientation of Sister Centromeres

    PubMed Central

    Blattner, Ariane C.; McKee, Bruce D.; Lehner, Christian F.

    2016-01-01

    Spatially controlled release of sister chromatid cohesion during progression through the meiotic divisions is of paramount importance for error-free chromosome segregation during meiosis. Cohesion is mediated by the cohesin protein complex and cleavage of one of its subunits by the endoprotease separase removes cohesin first from chromosome arms during exit from meiosis I and later from the pericentromeric region during exit from meiosis II. At the onset of the meiotic divisions, cohesin has also been proposed to be present within the centromeric region for the unification of sister centromeres into a single functional entity, allowing bipolar orientation of paired homologs within the meiosis I spindle. Separase-mediated removal of centromeric cohesin during exit from meiosis I might explain sister centromere individualization which is essential for subsequent biorientation of sister centromeres during meiosis II. To characterize a potential involvement of separase in sister centromere individualization before meiosis II, we have studied meiosis in Drosophila melanogaster males where homologs are not paired in the canonical manner. Meiosis does not include meiotic recombination and synaptonemal complex formation in these males. Instead, an alternative homolog conjunction system keeps homologous chromosomes in pairs. Using independent strategies for spermatocyte-specific depletion of separase complex subunits in combination with time-lapse imaging, we demonstrate that separase is required for the inactivation of this alternative conjunction at anaphase I onset. Mutations that abolish alternative homolog conjunction therefore result in random segregation of univalents during meiosis I also after separase depletion. Interestingly, these univalents become bioriented during meiosis II, suggesting that sister centromere individualization before meiosis II does not require separase. PMID:27120695

  14. Evaluation of dredged material proposed for ocean disposal from South Brother Island Channel, New York

    SciTech Connect

    Barrows, E.S.; Gardiner, W.W.; Antrim, L.D.; Gruendell, B.D.; Word, J.Q.; Tokos, J.J.S.

    1996-09-01

    South Brother Island Channel was one of seven waterways that the US Army Crops of Engineers-New York District requested the Battelle/Marine Sciences Laboratory to sample and evaluate for dredging and disposal. Tests and analyses were conducted on South Brother Island Channel sediment core samples and evaluations were performed. The evaluation of proposed dredged material from South Brother Island Channel included bulk sediment chemical analyses, chemical analyses of site water and elutriate, water-column and benthic acute toxicity tests, and bioaccumulation studies. Individual sediment core samples collected from Souther Brother Island Channel were analyzed for grain size, moisture content, and total organic carbon. a composite sediment sample, representing the entire area proposed for dredging, was analyzed for bulk density, specific gravity, metals, chlorinated pesticides, polychlorinated biphenyl congers, polynuclear aromatic hydrocarbons, and 1,4- dichlorobenzene. Site water and elutriate water, prepared from the suspended-particle phase of South Brother Island Channel sediment, were analyzed for metals, pesticides, and PCBs.

  15. A Profile and Perceptions of Fraternity Little Sister Auxiliary Groups.

    ERIC Educational Resources Information Center

    Scott, Peggy S.; Saracino, Marie

    1994-01-01

    Examined fraternity little sister auxiliary group members' perceptions of fraternity-related roles/experiences, and identified personality types of women who join such groups. Subjects (n=49) completed Auxiliary Group Questionnaire and Myers-Briggs Type Inventory. Results revealed that 83% of subjects could be classified as extraverted personality…

  16. Thrombotic thrombocytopenic purpura associated with pregnancy in two sisters.

    PubMed Central

    Alqadah, F.; Zebeib, M. A.; Awidi, A. S.

    1993-01-01

    Two sisters suffered from thrombotic thrombocytopenic purpura late in their first pregnancies. HLA typing of the patients and their immediate family members demonstrated no obvious relationship. Hereditary aspects, association with pregnancy, prognosis and management of pregnant women with TTP are discussed. PMID:8497440

  17. Precocious Sister Chromatid Separation (PSCS) in Cornelia de Lange Syndrome

    PubMed Central

    Kaur, Maninder; DeScipio, Cheryl; McCallum, Jennifer; Yaeger, Dinah; Devoto, Marcella; Jackson, Laird G.; Spinner, Nancy B.; Krantz, Ian D.

    2009-01-01

    The Cornelia de Lange syndrome (CdLS) (OMIM# 122470) is a dominantly inherited multisystem developmental disorder. The phenotype consists of characteristic facial features, hirsutism, abnormalities of the upper extremities ranging from subtle changes in the phalanges and metacarpal bones to oligodactyly and phocomelia, gastroesophageal dysfunction, growth retardation, and neurodevelopmental delay. Prevalence is estimated to be as high as 1 in 10,000. Recently, mutations in NIPBL were identified in sporadic and familial CdLS cases. To date, mutations in this gene have been identified in over 45% of individuals with CdLS. NIPBL is the human homolog of the Drosophila Nipped-B gene. Although its function in mammalian systems has not yet been elucidated, sequence homologs of Nipped-B in yeast (Scc2 and Mis4) are required for sister chromatid cohesion during mitosis, and a similar role was recently demonstrated for Nipped-B in Drosophila. In order to evaluate NIPBL role in sister chromatid cohesion in humans, metaphase spreads on 90 probands (40 NIPBL mutation positive and 50 NIPBL mutation negative) with CdLS were evaluated for evidence of precocious sister chromatid separation (PSCS). We screened 50 metaphases from each proband and found evidence of PSCS in 41% (compared to 9% in control samples). These studies indicate that NIPBL may play a role in sister chromatid cohesion in humans as has been reported for its homologs in Drosophila and yeast. PMID:16100726

  18. 7. STREAMSIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. STREAM-SIDE PATH BETWEEN THREE BRIDGE FALLS AND THREE SISTERS FALLS, LOOKING WEST Photocopy of photograph, 1930s National Park Service, National Capital Region files - Dumbarton Oaks Park, Thirty-second & R Streets Northwest, Washington, District of Columbia, DC

  19. Clinical Design Sciences: A View from Sister Design Efforts.

    ERIC Educational Resources Information Center

    Zaritsky, Raul; Kelly, Anthony E.; Flowers, Woodie; Rogers, Everett; O'Neill, Patrick

    2003-01-01

    Asserts that the social sciences are clinical-like endeavors, and the way that "sister" fields discover and validate their results may inform research practice in education. Describes three fields of design that confront similar societal demands for improvement (engineering product design, research on the diffusion of innovations, and management…

  20. DNA damage tolerance branches out toward sister chromatid cohesion

    PubMed Central

    Branzei, Dana

    2016-01-01

    ABSTRACT Genome duplication is temporarily coordinated with sister chromatid cohesion and DNA damage tolerance. Recently, we found that replication fork-coupled repriming is important for both optimal cohesion and error-free replication by recombination. The mechanism involved has implications for the etiology of replication-based genetic diseases and cancer. PMID:27308553

  1. Language and Cognitive Development of Deaf and Hearing Twin Sisters.

    ERIC Educational Resources Information Center

    Schirmer, Barbara R.

    In this case study, the language and cognitive development of a 4-year 5-month old profoundly deaf girl and her normally hearing identical twin sister were investigated by videotaping the twins in their home interacting with each other, the investigator, and family members. Materials used with the children were designed to elicit spontaneous,…

  2. TISSUE-SPECIFIC SISTER CHROMATID EXCHANGE ANALYSES IN MUTAGEN-CARCINOGEN EXPOSED ANIMALS

    EPA Science Inventory

    The phenomenon of sister chromatid exchange (SCE) has been extensively reviewed. Sister chromatid exchanges are intrachromosomal events, wherein segments of DNA are reciprocally swapped between the chromatids. They are most easily studied with 5-bromodeoxyuridine (BrdU) dye metho...

  3. Sibling Conversations about Dating and Sexuality: Sisters as Confidants, Sources of Support, and Mentors

    PubMed Central

    Killoren, Sarah E.; Roach, Andrea L.

    2013-01-01

    Using an observational methodology to examine sibling communication, sisters (N = 28 dyads) were videotaped discussing their ideas about dating and sexuality. Social provision theory was used as a framework for the examination of roles enacted by sisters during these conversations. Inductive thematic analytic procedures were conducted and three roles were identified: sisters as confidants, sources of support, and mentors. Older and younger sisters both served as confidants and sources of support for one another, whereas, older sisters were more likely to be mentors for their younger sisters than vice versa. Findings indicate the potential importance of sisters in the formation of adolescent girls’ ideas about romantic relationships and sexuality, sibling communication as a socialization mechanism of sisters’ similarities in romantic experiences and sexual behaviors/attitudes, and the inclusion of older sisters in prevention intervention programs focused on reducing adolescent sexual risk behaviors and promoting healthy romantic relationships and sexuality development. PMID:24659843

  4. Geologic map of Three Sisters volcanic cluster, Cascade Range, Oregon

    USGS Publications Warehouse

    Hildreth, Wes; Fierstein, Judy; Calvert, Andrew T.

    2012-01-01

    The cluster of glaciated stratovolcanoes called the Three Sisters—South Sister, Middle Sister, and North Sister—forms a spectacular 20-km-long reach along the crest of the Cascade Range in Oregon. The three eponymous stratocones, though contiguous and conventionally lumped sororally, could hardly display less family resemblance. North Sister (10,085 ft), a monotonously mafic edifice at least as old as 120 ka, is a glacially ravaged stratocone that consists of hundreds of thin rubbly lava flows and intercalated falls that dip radially and steeply; remnants of two thick lava flows cap its summit. Middle Sister (10,047 ft), an andesite-basalt-dacite cone built between 48 and 14 ka, is capped by a thick stack of radially dipping, dark-gray, thin mafic lava flows; asymmetrically glaciated, its nearly intact west flank contrasts sharply with its steep east face. Snow and ice-filled South Sister is a bimodal rhyolitic-intermediate edifice that was constructed between 50 ka and 2 ka; its crater (rim at 10,358 ft) was created between 30 and 22 ka, during the most recent of several explosive summit eruptions; the thin oxidized agglutinate that mantles its current crater rim protects a 150-m-thick pyroclastic sequence that helped fill a much larger crater. For each of the three, the eruptive volume is likely to have been in the range of 15 to 25 km³, but such estimates are fairly uncertain, owing to glacial erosion. The map area consists exclusively of Quaternary volcanic rocks and derivative surficial deposits. Although most of the area has been modified by glaciation, the volcanoes are young enough that the landforms remain largely constructional. Furthermore, twelve of the 145 eruptive units on the map are postglacial, younger than the deglaciation that was underway by about 17 ka. The most recent eruptions were of rhyolite near South Sister, about 2,000 years ago, and of mafic magma near McKenzie Pass, about 1,500 years ago. As observed by trailblazing volcanologist

  5. Two brothers with an unbalanced 8;17 translocation and infantile pyloric stenosis.

    PubMed

    Hodgson, S V; Berry, A C; Dunbar, H M

    1995-12-01

    Two half-brothers are described who had developmental delay and minor dysmorphic features, both of whom had operative treatment for pyloric stenosis. They had identical unbalanced karyotypes: 46,XY,-17,+der(17)t(8;17) (q24;q25). This was inherited from their mother who had the balanced form of the translocation. She was of normal intelligence and had no history of pyloric stenosis herself or in her extended family. It is suggested that the unbalanced chromosomal rearrangement could have been associated with the development of pyloric stenosis in these two brothers. PMID:8835331

  6. [Hepatic adenoma and hepatocellular carcinoma in 3 brothers with type I glycogenosis].

    PubMed

    Kharsa, G; Degott, C; Filoche, B; Hedde, J P; Potet, F; Benhamou, J P

    1990-01-01

    We report 2 cases of type I glycogen storage disease (Von Gierke's disease) discovered in 2 brothers at the age of 7 and 5 years, respectively. Both developed hepatic adenoma at the age of 19 and 17. Hepatocellular carcinoma occurred in the older brother the discovery of adenoma 4 years after. The frequency of these tumors in patients with type I glycogen storage disease raises problems concerning the treatment and modality of regular surveillance of the liver in these patients. The policy for the detection and treatment of these tumors, and particularly the indications for liver transplantation are discussed. PMID:2155841

  7. Sister Mary Joseph nodule-A case report with review of literature

    PubMed Central

    Dar, Ishrat Hussain; Kamili, Mqtasid Ahmed; Dar, Showkat Hussain; Kuchaai, Faiz Ahmed

    2009-01-01

    Sister Mary Joseph nodule or Sister Mary Joseph Sign refers to a palpable nodule bulging into the umbilicus as a result of metastasis of a malignant cancer in the pelvis or abdomen. A rare case of Sister Mary Joseph nodule, manifesting as ascites, cachexia and bleeding per rectum, is presented without any primary tumor despite extensive search for the same. PMID:21772912

  8. Keeping It in the Family: ATRX Loss Promotes Persistent Sister Telomere Cohesion in ALT Cancer Cells.

    PubMed

    Roake, Caitlin M; Artandi, Steven E

    2015-09-14

    In this issue of Cancer Cell, Ramamoorthy and Smith report that cancer cells that maintain their chromosome ends through alternative lengthening of telomeres (ALT) display persistent sister telomere cohesion. This delayed resolution of sister telomere cohesion depends upon the loss of ATRX and its histone-sequestering function and is associated with increased recombination between sister telomeres. PMID:26373274

  9. "Our Boys": The Christian Brothers and the Formation of Youth in the "New Ireland"1914-1944

    ERIC Educational Resources Information Center

    Keogh, Daire

    2015-01-01

    This essay investigates the development of the boys' magazine, "Our Boys," and how this became a powerful auxiliary to the Christian Brothers' work in schools. It championed the values that the Christian Brothers had propagated since their foundation in 1802. Often characterised as Celtic and Romantic, it was neither, but aimed at…

  10. Dual of big bang and big crunch

    SciTech Connect

    Bak, Dongsu

    2007-01-15

    Starting from the Janus solution and its gauge theory dual, we obtain the dual gauge theory description of the cosmological solution by the procedure of double analytic continuation. The coupling is driven either to zero or to infinity at the big-bang and big-crunch singularities, which are shown to be related by the S-duality symmetry. In the dual Yang-Mills theory description, these are nonsingular as the coupling goes to zero in the N=4 super Yang-Mills theory. The cosmological singularities simply signal the failure of the supergravity description of the full type IIB superstring theory.

  11. Implementing Big History.

    ERIC Educational Resources Information Center

    Welter, Mark

    2000-01-01

    Contends that world history should be taught as "Big History," a view that includes all space and time beginning with the Big Bang. Discusses five "Cardinal Questions" that serve as a course structure and address the following concepts: perspectives, diversity, change and continuity, interdependence, and causes. (CMK)

  12. Big Ideas in Art

    ERIC Educational Resources Information Center

    Day, Kathleen

    2008-01-01

    In this article, the author shares how she was able to discover some big ideas about art education. She relates how she found great ideas to improve her teaching from the book "Rethinking Curriculum in Art." She also shares how she designed a "Big Idea" unit in her class.

  13. Socio-Technical Systems Analysis and Manufacturing Technology: Addressing "Big Brother" and Computers in Blue-Collar Work.

    ERIC Educational Resources Information Center

    Taylor, James C.

    For more than 80 years, jobs in the United States have been designed by people for others. For most of these years, the experts in job design have placed the production technology above the job holder in importance. Since the 1950s, many jobs have been redesigned around new, computer-based technology. Often, the net effect has been to make those…

  14. Is Big Brother Watching You? The Evolving Role of the State in Regulating and Conducting Quality Assurance. CIQG Publication Series

    ERIC Educational Resources Information Center

    Salmi, Jamil

    2015-01-01

    A recent report published in the United Kingdom proposed the image of "an avalanche" to describe the radical changes affecting tertiary education in many parts of the world (Barber, Donnelly and Rizvi, 2013). Indeed, powerful transformative forces of three kinds--rupture factors, crisis factors and stimulus factors--are challenging…

  15. Supernova 2013fc in a circumnuclear ring of a luminous infrared galaxy: the big brother of SN 1998S

    NASA Astrophysics Data System (ADS)

    Kangas, T.; Mattila, S.; Kankare, E.; Lundqvist, P.; Väisänen, P.; Childress, M.; Pignata, G.; McCully, C.; Valenti, S.; Vinkó, J.; Pastorello, A.; Elias-Rosa, N.; Fraser, M.; Gal-Yam, A.; Kotak, R.; Kotilainen, J. K.; Smartt, S. J.; Galbany, L.; Harmanen, J.; Howell, D. A.; Inserra, C.; Marion, G. H.; Quimby, R. M.; Silverman, J. M.; Szalai, T.; Wheeler, J. C.; Ashall, C.; Benetti, S.; Romero-Cañizales, C.; Smith, K. W.; Sullivan, M.; Takáts, K.; Young, D. R.

    2016-02-01

    We present photometric and spectroscopic observations of SN 2013fc, a bright type II supernova (SN) in a circumnuclear star-forming ring in the luminous infrared galaxy ESO 154-G010, observed as part of the Public ESO Spectroscopic Survey of Transient Objects. SN 2013fc is both photometrically and spectroscopically similar to the well-studied type IIn SN 1998S and to the bright type II-L SN 1979C. It exhibits an initial linear decline, followed by a short plateau phase and a tail phase with a decline too fast for 56Co decay with full γ-ray trapping. Initially, the spectrum was blue and featureless. Later on, a strong broad (˜8000 km s-1) H α emission profile became prominent. We apply a STARLIGHT stellar population model fit to the SN location (observed when the SN had faded) to estimate a high extinction of AV = 2.9 ± 0.2 mag and an age of 10_{-2}^{+3} Myr for the underlying cluster. We compare the SN to SNe 1998S and 1979C and discuss its possible progenitor star considering the similarities to these events. With a peak brightness of B = -20.46 ± 0.21 mag, SN 2013fc is 0.9 mag brighter than SN 1998S and of comparable brightness to SN 1979C. We suggest that SN 2013fc was consistent with a massive red supergiant (RSG) progenitor. Recent mass loss probably due to a strong RSG wind created the circumstellar matter illuminated through its interaction with the SN ejecta. We also observe a near-infrared excess, possibly due to newly condensed dust.

  16. THE E3 UBIQUITIN LIGASE BIG BROTHER CONTROLS ARABIDOPSIS ORGAN SIZE IN A DOSAGE-DEPENDENT MANNER

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Organ growth up to a species-specific size is tightly regulated in plants and animals 1; 2. Final organ size is remarkably constant within a given species, suggesting that a species-specific size checkpoint terminates organ growth in a coordinated and timely manner. Phytohormones influence plant org...

  17. Big data for health.

    PubMed

    Andreu-Perez, Javier; Poon, Carmen C Y; Merrifield, Robert D; Wong, Stephen T C; Yang, Guang-Zhong

    2015-07-01

    This paper provides an overview of recent developments in big data in the context of biomedical and health informatics. It outlines the key characteristics of big data and how medical and health informatics, translational bioinformatics, sensor informatics, and imaging informatics will benefit from an integrated approach of piecing together different aspects of personalized information from a diverse range of data sources, both structured and unstructured, covering genomics, proteomics, metabolomics, as well as imaging, clinical diagnosis, and long-term continuous physiological sensing of an individual. It is expected that recent advances in big data will expand our knowledge for testing new hypotheses about disease management from diagnosis to prevention to personalized treatment. The rise of big data, however, also raises challenges in terms of privacy, security, data ownership, data stewardship, and governance. This paper discusses some of the existing activities and future opportunities related to big data for health, outlining some of the key underlying issues that need to be tackled. PMID:26173222

  18. Sister chromatid junctions in the hyperthermophilic archaeon Sulfolobus solfataricus

    PubMed Central

    Robinson, Nicholas P; Blood, Katherine A; McCallum, Simon A; Edwards, Paul A W; Bell, Stephen D

    2007-01-01

    Although the Archaea exhibit an intriguing combination of bacterial- and eukaryotic-like features, it is not known how these prokaryotic cells segregate their chromosomes before the process of cell division. In the course of our analysis of the third replication origin in the archaeon Sulfolobus solfataricus, we identify and characterise sister chromatid junctions in this prokaryote. This pairing appears to be mediated by hemicatenane-like structures, and we provide evidence that these junctions persist in both replicating and postreplicative cells. These data, in conjunction with fluorescent in situ hybridisation analyses, suggest that Sulfolobus chromosomes have a significant period of postreplicative sister chromatid synapsis, a situation that is more reminiscent of eukaryotic than bacterial chromosome segregation mechanisms. PMID:17255945

  19. [The duties of Sisters of Mercy in light of documents].

    PubMed

    Hałat, S M

    1999-01-01

    There are numerous documents in the Archives kept by the Convent of the Sisters of Mercy that refer to the taking care of the sick and hospitalization. The article depicts the regulations applicable in the hospital of Angers dating back to the 17th century (reprinted from the French work about St. Vincent a Paulo) and the Polish regulations from the period between the World War I and II kept in the Polish archives. PMID:14631983

  20. Broad Phylogenomic Sampling and the Sister Lineage of Land Plants

    PubMed Central

    Timme, Ruth E.; Bachvaroff, Tsvetan R.; Delwiche, Charles F.

    2012-01-01

    The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that ‘stoneworts,’ or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as “pond scum”) as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae. PMID:22253761

  1. Southall Black Sisters. Hannana Siddiqui speaks to Rasna Warah.

    PubMed

    Warah, R

    1994-01-01

    Southall Black Sisters, an organization for Asian and Afro-Caribbean women in Great Britain, was established in 1979 at the height of anti-racist protests to address the otherwise neglected issue of women's oppression. The group has campaigned against discriminatory immigration laws, illegal virginity tests at Heathrow airport, domestic violence, and other issues of particular concern to British Asian women. Women who migrate to England for an arranged marriage must remain with their husband at least 1 year or face deportation and denial of any public assistance, placing them at risk of unreported domestic violence. Southall Black Sisters has attempted to raise the public consciousness about domestic violence as a criminal issue and garner support for Asian women who leave abusive husbands. However, no support has been forthcoming from the anti-racist movement, which fears that publicity on domestic violence will create a racist backlash against Asian men. More support has been available for the group's campaign to protect battered women who kill their husbands by removing from the law on provocation the need for an immediate response. Another campaign has involved protests against "bounty hunters" hired by Asian families to return girls who have escaped from arranged marriages in their home country or sexual abuse within their family. Southall Black Sisters attributes many of the problems faced by its clients to a rise in religious fundamentalism and Muslim attempts to reverse the gains of the feminist movement. PMID:12287625

  2. Malignant Triton Tumors in Sisters with Clinical Neurofibromatosis Type 1

    PubMed Central

    Alina, Basnet; Sebastian, Jofre A.; Gerardo, Capo

    2015-01-01

    Malignant triton tumors (MTTs) are rare and aggressive sarcomas categorized as a subgroup of malignant peripheral nerve sheath tumors (MPNSTs). MTTs arise from Schwann cells of peripheral nerves or existing neurofibromas and have elements of rhabdomyoblastic differentiation. We report the occurrence of MTTs in two sisters. The first patient is a 36-year-old female who presented with left sided chest wall swelling. She also had clinical features consistent with neurofibromatosis type 1 (NF-1). Debulking of the mass showed high-grade malignant peripheral nerve sheath tumor with skeletal muscle differentiation (MTT). The patient was treated with ifosfamide and adriamycin along with radiation. Four years after treatment, she still has no evidence of disease recurrence. Her sister subsequently presented to us at the age of 42 with left sided lateral chest wall pain. Imaging showed a multicompartmental retroperitoneal cystic mass with left psoas involvement. The tumor was resected and, similarly to her sister, it showed high-grade malignant peripheral nerve sheath tumor with rhabdomyoblastic differentiation (MTT). The patient was started on chemotherapy and radiation as described above. PMID:26114002

  3. Broad phylogenomic sampling and the sister lineage of land plants.

    PubMed

    Timme, Ruth E; Bachvaroff, Tsvetan R; Delwiche, Charles F

    2012-01-01

    The tremendous diversity of land plants all descended from a single charophyte green alga that colonized the land somewhere between 430 and 470 million years ago. Six orders of charophyte green algae, in addition to embryophytes, comprise the Streptophyta s.l. Previous studies have focused on reconstructing the phylogeny of organisms tied to this key colonization event, but wildly conflicting results have sparked a contentious debate over which lineage gave rise to land plants. The dominant view has been that 'stoneworts,' or Charales, are the sister lineage, but an alternative hypothesis supports the Zygnematales (often referred to as "pond scum") as the sister lineage. In this paper, we provide a well-supported, 160-nuclear-gene phylogenomic analysis supporting the Zygnematales as the closest living relative to land plants. Our study makes two key contributions to the field: 1) the use of an unbiased method to collect a large set of orthologs from deeply diverging species and 2) the use of these data in determining the sister lineage to land plants. We anticipate this updated phylogeny not only will hugely impact lesson plans in introductory biology courses, but also will provide a solid phylogenetic tree for future green-lineage research, whether it be related to plants or green algae. PMID:22253761

  4. Big data, big knowledge: big data for personalized healthcare.

    PubMed

    Viceconti, Marco; Hunter, Peter; Hose, Rod

    2015-07-01

    The idea that the purely phenomenological knowledge that we can extract by analyzing large amounts of data can be useful in healthcare seems to contradict the desire of VPH researchers to build detailed mechanistic models for individual patients. But in practice no model is ever entirely phenomenological or entirely mechanistic. We propose in this position paper that big data analytics can be successfully combined with VPH technologies to produce robust and effective in silico medicine solutions. In order to do this, big data technologies must be further developed to cope with some specific requirements that emerge from this application. Such requirements are: working with sensitive data; analytics of complex and heterogeneous data spaces, including nontextual information; distributed data management under security and performance constraints; specialized analytics to integrate bioinformatics and systems biology information with clinical observations at tissue, organ and organisms scales; and specialized analytics to define the "physiological envelope" during the daily life of each patient. These domain-specific requirements suggest a need for targeted funding, in which big data technologies for in silico medicine becomes the research priority. PMID:26218867

  5. The Liability of Having Brothers: Paying for College and the Sex Composition of the Family.

    ERIC Educational Resources Information Center

    Powell, Brian; Steelman, Lala Carr

    1989-01-01

    Examines effects that the sex composition of family has upon ways in which families finance higher education. Finds that as the number of brothers increases, the likelihood that a student will meet his financial obligation through means other than parental contribution becomes greater. Suggests sex composition is a structural element of the…

  6. Sibling Communication in "Star Trek: The Next Generation": Conflicts between Brothers.

    ERIC Educational Resources Information Center

    Fuss-Reineck, Marilyn

    "Star Trek: The Next Generation" depicts sibling relationships between Data and Lore (android), Worf and Kurn (Klingon) and Jean-Luc and Robert (human) that illustrate conflictual communication and suggest teaching applications. The most disturbing empirical communication research on conflict between brothers reports that male sibling pairs are…

  7. The Wright Brothers and the Future of Bio-Inspired Flight: 1899 through to the Future

    NASA Technical Reports Server (NTRS)

    Bowers, Albion

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that proceeded the first powered flight.

  8. The Irish Christian Brothers and the National Board of Education: Challenging the Myths

    ERIC Educational Resources Information Center

    McLaughlin, Denis

    2008-01-01

    For close to 170 years the general consensus from historians has been that Edmund Rice, who founded the Irish Christian Brothers in 1802, was an unenthusiastic applicant to the National Board of Education in Ireland in 1832 and later withdrew his schools because he believed his education was incompatible with the philosophy underpinning the…

  9. 75 FR 30831 - Cooksey Brothers Landfill Fire Superfund Site; Ashland, Boyd County, KY; Notice of Settlement

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-02

    ...Under Section 122(h)(1) of the Comprehensive Environmental Response, Compensation and Liability Act (CERCLA), the United States Environmental Protection Agency has entered into a settlement for reimbursement of past response costs concerning the Cooksey Brothers Landfill Fire Superfund Site located in Ashland, Boyd County, Kentucky for...

  10. Another Look at Vividness in the Trial of Two Vietnamese Brothers.

    ERIC Educational Resources Information Center

    Bresnahan, Mary I.

    A study examined the trial of People v. Tien (two Vietnamese brothers named defendants in an assault case). In order to understand better the relationship between supportive speech acts and credibility, the study examined how the attorney elicited vivid testimony. One of the ways in which an attorney yields control of testimony to a witness is by…

  11. Two Brothers, Two Cities: Music Education in Boston and Cincinnati from 1830-1844

    ERIC Educational Resources Information Center

    Lenzo, Terri Brown; Resta, Craig

    2011-01-01

    The birth of American music education is often attributed solely to Lowell Mason in Boston. His younger brother Timothy, however, was also active at the same time in Cincinnati. This study traces the roots of music education in both cities, but highlights the rarely cited accomplishments of Timothy Mason and his colleagues. Using historical…

  12. When Your "Problem" Becomes Mine: Adult Female Siblings' Perspectives of Having a Brother with a Disability

    ERIC Educational Resources Information Center

    Pompeo, Michelle N.

    2009-01-01

    This study is a retrospective look at adult female siblings' perspectives of their childhoods and present identities based on having a brother with a disability. This paper focuses on siblings' experiences within educational and public domains, and how such experiences have shaped their personalities and career choices. Qualitative findings were…

  13. Blood Brothers: Albert and Allen Hughes in the Belly of the Hollywood Beast.

    ERIC Educational Resources Information Center

    Gates, Henry Louis, Jr.

    1994-01-01

    Recounts an interview with the Hughes brothers, who are twin black men who produced the film "Menace 2 Society," which is a film about urban delinquency and crime among black adolescents. Their comments include thoughts on racism, media stereotyping, being black in America, and their experiences with Hollywood. (GLR)

  14. A Thousand Lights [and] A Thousand Lights: Teacher and Parent Guide. Brothers Series.

    ERIC Educational Resources Information Center

    Benton, Hope

    This book for children (ages 8 to 14) and the accompanying teacher/parent guide present the story of two brothers, one of whom has a severe hearing impairment, who climb up Mt. Fuji in Japan. Information on the disability is presented subtly and incidentally to encourage the reader to relate more personally and foster a deeper level of acceptance…

  15. The Role of Digital Literacy Practices on Refugee Resettlement: The Case of Three Karen Brothers

    ERIC Educational Resources Information Center

    Gilhooly, Daniel; Lee, Eunbae

    2014-01-01

    This study explores the social and cultural uses of digital literacies by adolescent immigrants to cope with their new lives in the United States. This case study focuses on three adolescent ethnic Karen brothers. Two years of participant observations in their home and Karen community, accompanied by formal and informal interviews, served as the…

  16. Circuits of Spectacle: The Miller Brothers' 101 Ranch Real Wild West

    ERIC Educational Resources Information Center

    Fields, Alison

    2012-01-01

    The Miller Brothers' 101 Ranch Real Wild West show ran from 1906 to 1931, outlasting the famous Buffalo Bill's Wild West show by more than a decade. From its beginnings in Oklahoma Territory, the Real Wild West show traveled national and international circuits and built a broad roster of performers, including more than 150 American Indians. During…

  17. Gliding Experiments of the Wright Brothers: The Wrights and Flight Research 1899-1908

    NASA Technical Reports Server (NTRS)

    Bowers, Al; Cole, Jennifer Hansen; Martin, Cam

    2007-01-01

    This viewgraph presentation reviews the experiments that the Wright Brothers conducted prior to their first powered flight in 1903 to developing the first practical aircraft in 1905. Many pictures of the gliders and other devices are used to illustrate the gradual development and experimentation that preceeded the first powered flight.

  18. 3 CFR 9071 - Proclamation 9071 of December 16, 2013. Wright Brothers Day, 2013

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 3 The President 1 2014-01-01 2014-01-01 false Proclamation 9071 of December 16, 2013. Wright... December 16, 2013 Proc. 9071 Wright Brothers Day, 2013By the President of the United States of America A... seconds of flight. Wilbur and Orville Wright's airplane soared above the wind-blown banks of Kitty...

  19. My Brother as "Problem": Neoliberal Governmentality and Interventions for Black Young Men and Boys

    ERIC Educational Resources Information Center

    Dumas, Michael J.

    2016-01-01

    In this article, the author argues that the Obama Administration's My Brother's Keeper (MBK) initiative serves as an exemplar of neoliberal governmentality, in which Black young men and boys are constructed as essentially damaged, as problems in need of a technocratic public--private solution. More than simply an ideological imposition from above…

  20. Family Configuration and Achievement: Effects of Birth Order and Family Size in a Sample of Brothers.

    ERIC Educational Resources Information Center

    Olneck, Michael R.; Bills, David B.

    1979-01-01

    Birth order effects in brothers were found to derive from difference in family size. Effects for family size were found even with socioeconomic background controlled. Nor were family size effects explained by parental ability. The importance of unmeasured preferences or economic resources that vary across families was suggested. (Author/RD)

  1. Evidence of environmental suppression of familial resemblance: height among US Civil War brothers.

    PubMed

    Lauderdale, D S; Rathouz, P J

    1999-01-01

    This study examines, with historical data, whether within family correlations in height varied across environments and whether variability in height was greater in worse environments. To investigate these hypotheses, brothers were identified who were mustered into the Union Army of the US Civil War, using linked records from the 1850 and 1860 censuses and military and medical records. Heights were available for 3898 men aged 18 and older, of whom 595 were further identified as belonging to 288 family sets of two, three or four brothers. Generalized estimating equations were used to concurrently model the mean height, the variance and the correlation between brothers as a function of county population. Heights decreased as county population size increased (p<0.001). The correlation between brothers' heights decreased significantly (p = 0.032) with increasing county population, and the variance increased (p = 0.026). The correlation ranged approximately from 0.63 in the least populous to 0.24 in the most populous counties. The degree of familial resemblance was lower in environments where mean height was lower, and the variability in height was greater, suggesting that the environmental contribution to the variability in height is of greater relative importance in populations reared, on average, in worse environments. PMID:10541404

  2. 3 CFR 8466 - Proclamation 8466 of December 16, 2009. Wright Brothers Day, 2009

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... alter our world. Today, we honor the enduring American spirit of creativity and innovation that made the... the ageless dream of controlled flight, they persevered through great challenges. Early design... workshop where American innovators still tinker, invent, and discover. The next Wright Brothers are...

  3. Strain gradients and melt pathways, Twin Sisters complex, Washington State

    NASA Astrophysics Data System (ADS)

    Kruckenberg, S. C.; Newman, J.; Tikoff, B.; Toy, V. G.

    2009-12-01

    The Twin Sisters complex in the North Cascades of Washington state is a large (~6 by 16 km), virtually unaltered ultramafic body that provides information about the relationships between the formation of compositional layering, structural fabrics and the formation of inferred melt pathways in naturally deforming peridotites. Compositional layering is largely defined by alternating layers of orthopyroxene-absent dunite (>95% olivine) and orthopyroxene-present (~15% orthopyroxene; ~85% olivine) harzburgite aligned parallel to a roughly N-S striking and steeply dipping foliation. Orthopyroxene- and clinopyroxene-bearing dikes occur throughout the Twin Sisters and crosscut the host dunite and harzburgite layering. Orthopyroxene dikes range in thickness from 1 cm to >1 m and are variably oriented and may be folded. Clinopyroxene-bearing dikes are thinner, more consistently oriented (~N-S), and generally more tabular than the orthopyroxene dikes. In the Twin Sisters, cm- to m-scale zones of porphyroclastic dunite cross-cut the main dunite-harzburgite compositional layering and display a variety of relationships with pyroxene dikes in the region. These porphyroclastic dunite bands locally contain single olivine grains >10 cm and likely represent former pathways of melt migration. Transect mapping along an E-W traverse across the Twin Sisters massif reveals that these inferred melt channels form at various angles relative to the main dunite-harzburgite layering. In the west, porphyroclastic olivine layers form at low angle to the main foliation and compositional layering. These zone form at systematically higher angles across the structural section of the Twin Sisters massif to the east and commonly form conjugate cross-cutting sets at high-angle to the main N-S dunite-harzburgite layering. This change in band angle correlates broadly with changes in the intensity of folding of orthopyroxene-bearing dikes, with more intensely deformed dikes in the west to more planar dikes

  4. Big Data in industry

    NASA Astrophysics Data System (ADS)

    Latinović, T. S.; Preradović, D. M.; Barz, C. R.; Latinović, M. T.; Petrica, P. P.; Pop-Vadean, A.

    2016-08-01

    The amount of data at the global level has grown exponentially. Along with this phenomena, we have a need for a new unit of measure like exabyte, zettabyte, and yottabyte as the last unit measures the amount of data. The growth of data gives a situation where the classic systems for the collection, storage, processing, and visualization of data losing the battle with a large amount, speed, and variety of data that is generated continuously. Many of data that is created by the Internet of Things, IoT (cameras, satellites, cars, GPS navigation, etc.). It is our challenge to come up with new technologies and tools for the management and exploitation of these large amounts of data. Big Data is a hot topic in recent years in IT circles. However, Big Data is recognized in the business world, and increasingly in the public administration. This paper proposes an ontology of big data analytics and examines how to enhance business intelligence through big data analytics as a service by presenting a big data analytics services-oriented architecture. This paper also discusses the interrelationship between business intelligence and big data analytics. The proposed approach in this paper might facilitate the research and development of business analytics, big data analytics, and business intelligence as well as intelligent agents.

  5. BigDog

    NASA Astrophysics Data System (ADS)

    Playter, R.; Buehler, M.; Raibert, M.

    2006-05-01

    BigDog's goal is to be the world's most advanced quadruped robot for outdoor applications. BigDog is aimed at the mission of a mechanical mule - a category with few competitors to date: power autonomous quadrupeds capable of carrying significant payloads, operating outdoors, with static and dynamic mobility, and fully integrated sensing. BigDog is about 1 m tall, 1 m long and 0.3 m wide, and weighs about 90 kg. BigDog has demonstrated walking and trotting gaits, as well as standing up and sitting down. Since its creation in the fall of 2004, BigDog has logged tens of hours of walking, climbing and running time. It has walked up and down 25 & 35 degree inclines and trotted at speeds up to 1.8 m/s. BigDog has walked at 0.7 m/s over loose rock beds and carried over 50 kg of payload. We are currently working to expand BigDog's rough terrain mobility through the creation of robust locomotion strategies and terrain sensing capabilities.

  6. The Big Bang Theory

    SciTech Connect

    Lincoln, Don

    2014-09-30

    The Big Bang is the name of the most respected theory of the creation of the universe. Basically, the theory says that the universe was once smaller and denser and has been expending for eons. One common misconception is that the Big Bang theory says something about the instant that set the expansion into motion, however this isn’t true. In this video, Fermilab’s Dr. Don Lincoln tells about the Big Bang theory and sketches some speculative ideas about what caused the universe to come into existence.

  7. The Big Bang Singularity

    NASA Astrophysics Data System (ADS)

    Ling, Eric

    The big bang theory is a model of the universe which makes the striking prediction that the universe began a finite amount of time in the past at the so called "Big Bang singularity." We explore the physical and mathematical justification of this surprising result. After laying down the framework of the universe as a spacetime manifold, we combine physical observations with global symmetrical assumptions to deduce the FRW cosmological models which predict a big bang singularity. Next we prove a couple theorems due to Stephen Hawking which show that the big bang singularity exists even if one removes the global symmetrical assumptions. Lastly, we investigate the conditions one needs to impose on a spacetime if one wishes to avoid a singularity. The ideas and concepts used here to study spacetimes are similar to those used to study Riemannian manifolds, therefore we compare and contrast the two geometries throughout.

  8. The Impact of School-Based Mentoring on Youths with Different Relational Profiles

    ERIC Educational Resources Information Center

    Schwartz, Sarah E. O.; Rhodes, Jean E.; Chan, Christian S.; Herrera, Carla

    2011-01-01

    Associations between youths' relationship profiles and mentoring outcomes were explored in the context of a national, randomized study of 1,139 youths (54% female) in geographically diverse Big Brothers Big Sisters school-based mentoring programs. The sample included youths in Grades 4-9 from diverse racial and ethnic backgrounds, the majority of…

  9. Review of Three Recent Randomized Trials of School-Based Mentoring: Making Sense of Mixed Findings. Social Policy Report. Volume 24, Number 3

    ERIC Educational Resources Information Center

    Wheeler, Marc E.; Keller, Thomas E.; DuBois, David L.

    2010-01-01

    Between 2007 and 2009, reports were released on the results of three separate large-scale random assignment studies of the effectiveness of school-based mentoring programs for youth. The studies evaluated programs implemented by Big Brothers Big Sisters of America (BBBSA) affiliates (Herrera et al., 2007), Communities In Schools of San Antonio,…

  10. Culture, Context, and Innovation: A Kiwi Canuck Perspective

    ERIC Educational Resources Information Center

    Marshall, Dave; Shaver, Karen

    2010-01-01

    This commentary lends a global practitioner perspective on the utility of this volume to the efforts of mentors and mentees and mentoring program developers. Dave Marshall and Karen Shaver, of Big Brothers Big Sisters New Zealand and Canada, respectively, offer keen insights into the value of creating a shared language for discussing mentoring…

  11. Pathways of Influence in School-Based Mentoring: The Mediating Role of Parent and Teacher Relationships

    ERIC Educational Resources Information Center

    Chan, Christian S.; Rhodes, Jean E.; Howard, Waylon J.; Lowe, Sarah R.; Schwartz, Sarah E. O.; Herrera, Carla

    2013-01-01

    This study explores the pathways through which school-based mentoring relationships are associated with improvements in elementary and high school students' socio-emotional, academic, and behavioral outcomes. Participants in the study (N = 526) were part of a national evaluation of the Big Brothers Big Sisters school-based mentoring programs, all…

  12. Meeting the Challenge of Doing an RCT Evaluation of Youth Mentoring in Ireland: A Journey in Mixed Methods

    ERIC Educational Resources Information Center

    Brady, Bernadine; O'Regan, Connie

    2009-01-01

    The youth mentoring program Big Brothers Big Sisters is one of the first social interventions involving youth in Ireland to be evaluated using a randomized controlled trial methodology. This article sets out the design process undertaken, describing how the research team came to adopt a concurrent embedded mixed methods design as a means of…

  13. Mainstreaming: A Model for Including Elementary Students in the Severely Handicapped Classroom.

    ERIC Educational Resources Information Center

    Almond, Patricia; And Others

    1979-01-01

    Using the concepts of normalization, mainstreaming, and individualized instruction, a big brother/big sister program was developed in which 16 severely handicapped autistic children (4 to 15 years old) were tutored by nonhandicapped and educable mentally retarded elementary students. (CL)

  14. School-Based Mentoring Programs: Using Volunteers to Improve the Academic Outcomes of Underserved Students

    ERIC Educational Resources Information Center

    Bayer, Amanda; Grossman, Jean Baldwin; DuBois, David L.

    2013-01-01

    Previous research suggests that school-based mentoring programs like those offered by Big Brothers Big Sisters of America (BBBSA) yield small but statistically significant improvements in the academic performance of mentored students and in their beliefs in their own scholastic efficacy. The present study uses data from a randomized control trial…

  15. What's in a Relationship? An Examination of Social Capital, Race and Class in Mentoring Relationships

    ERIC Educational Resources Information Center

    Gaddis, S. Michael

    2012-01-01

    After 25 years of intense scrutiny, social capital remains an important yet highly debated concept in social science research. This research uses data from youth and mentors in several chapters of Big Brothers/Big Sisters to assess the importance of different mentoring relationship characteristics in creating positive outcomes among youths. The…

  16. How Big Are "Martin's Big Words"? Thinking Big about the Future.

    ERIC Educational Resources Information Center

    Gardner, Traci

    "Martin's Big Words: The Life of Dr. Martin Luther King, Jr." tells of King's childhood determination to use "big words" through biographical information and quotations. In this lesson, students in grades 3 to 5 explore information on Dr. King to think about his "big" words, then they write about their own "big" words and dreams. During the one…

  17. 10. Photocopy of photograph showing the three Walker sisters ginning ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    10. Photocopy of photograph showing the three Walker sisters ginning cotton. Misses Hettie, Martha and Louisa are from left to right. The original photograph was taken on May 21, 1936 by Edouard E. Exline and is one of five photographs in the album, 'A Sketch of Mountain Life: Great Smoky Mountains National Park', compiled by Edouard E. Exline and C.S. Grossman. The album is on file at the Great Smoky Mountains National Park; the photograph number is III-A-HSE-9642. - Walker Family Farm (General views), Gatlinburg, Sevier County, TN

  18. Catholic Sister Nurses in Selma, Alabama, 1940–1972

    PubMed Central

    Wall, Barbra Mann

    2009-01-01

    This study analyzes the activities of religious sister nurses as they confronted racism in the American South from 1940 to 1972. Selma was chosen as a case study because, in the 1960s, events in that southern town marked a turning point in the civil rights movement in the United States. This is a story about the workings of gender, race, religion, and nursing. The sisters’ work demonstrates how an analysis of race in nursing history is incomplete without an understanding of the roles that a number of Catholic religious women took in reaching out to African Americans in the Deep South. PMID:19218843

  19. Agenesis of the Gallbladder in Monozygotic Twin Sisters

    PubMed Central

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed “gallbladder agenesis.” Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274

  20. Agenesis of the Gallbladder in Monozygotic Twin Sisters.

    PubMed

    Hoshi, Koki; Irisawa, Atsushi; Shibukawa, Goro; Yamabe, Akane; Fujisawa, Mariko; Igarashi, Ryo; Sato, Ai; Maki, Takumi

    2016-01-01

    Agenesis of the gallbladder, a rare anomaly, is generally regarded as an organogenic failure. Several reports suggest that this congenital defect is inherited but that supposition remains controversial. We described agenesis of the gallbladder in identical twins. A 21-year-old female presented with a history of acute pain in the epigastrium and right hypochondrium. Various imaging modalities showed "gallbladder agenesis." Moreover, her older identical twin sister had also no visualized gallbladder in imaging modalities. This case report strongly suggested that agenesis of the gallbladder would be caused by a genetic abnormality. PMID:26925274

  1. Eating attitudes and behaviors of anorexia nervosa patients and their sisters.

    PubMed

    Maloney, M J; Shepard-Spiro, P

    1983-12-01

    Although the sisters of anorexia nervosa patients may have an increased risk for this disorder, there are no controlled studies of the eating patterns and attitudes of the normal sisters of anorexic patients. Twenty-one sister pairs (anorexics and their normal sisters) were interviewed and given the Eating Attitude Test (EAT) to compare their eating attitudes and behaviors. The mean scores on the EAT and its three subscales (measuring "Dieting," "Bulimia and Food Preoccupation," and "Oral Control") were significantly correlated with criterion group membership (p less than 0.0001). The normal sisters as a group did not demonstrate anorexic eating attitudes. However, two normal sisters did score in the anorexic range and are being followed prospectively. The EAT questionnaire could be used to screen vulnerable siblings of patients with anorexia nervosa for early signs of this disorder. PMID:6662359

  2. Pregnancy risk among the younger sisters of pregnant and childbearing adolescents.

    PubMed

    East, P L; Felice, M E

    1992-04-01

    There is increasing evidence that younger sisters of childbearing teenagers are at increased risk for adolescent childbearing. We critically review this research and discuss three plausible theoretical explanations (social modeling, shared parenting influences, and shared societal risk) why the younger sisters of childbearing adolescents would themselves be at risk for teenage pregnancy. Considerations for preventive interventions aimed at the younger sisters of pregnant teenagers and directions for future research are discussed. PMID:1577959

  3. Brotherly Advice: Letters from Hugo to Paul Ehrenfest in his Final Years

    NASA Astrophysics Data System (ADS)

    Halpern, Paul

    2006-03-01

    At the start of the 1930s, theoretician Paul Ehrenfest spent much of his time traveling through America and Europe while engaged in a steady stream of lectures. This traveling phase coincided with a frantic and intense period of negative self-examination, financial difficulty, and various other personal concerns that would ultimately lead to his 1933 suicide. Throughout these final years, he kept up a steady correspondence with his brother Hugo, a physician based in Saint Louis. Ten years older than Paul, Hugo freely doled out frank psychological advice about subjects ranging from the proper treatment of children to the dangers of self-pity. Through a look at some of the letters exchanged between the two brothers, this talk will examine the role Hugo played during the dark final years of Paul Ehrenfest's life.

  4. Sister-sister in vitro fertilization surrogate pregnancy with donor sperm: the case for surrogate gestational pregnancy.

    PubMed

    Leeton, J; King, C; Harman, J

    1988-10-01

    A case of surrogate pregnancy is described in the sister of a 40-year-old hysterectomized woman where two oocytes of the latter were fertilized in vitro with known donor sperm and transferred into the surrogate. A normal singleton pregnancy developed which was complicated after 24 weeks of gestation with recurrent antepartum hemorrhages due to grade 3 placenta praevia. A healthy female baby was delivered by elective cesarean section at 36 weeks of gestation. The legal, social, psychological, and ethical issues of surrogacy remain unsettled and are discussed in this case report. PMID:3230346

  5. Learning to Fly: The Wright Brothers' Adventure. A Guide for Educators and Students with Activities in Aeronautics

    NASA Technical Reports Server (NTRS)

    Storm, R.; Benson, T.; Galica, C.; McCredie, P.

    2003-01-01

    This guide was produced by the NASA Glenn Research Center Office of Educational Programs in Cleveland, OH, and the NASA Aerospace Educational Coordinating Committee. It includes activity modules for students, including the history of the Wright Brothers and their family in Dayton, Ohio and flight experimentation in Kitty Hawk, North Carolina. Student activities such as building models of the Wright Brothers glider and writing press releases of the initial flight are included.

  6. Condensin II initiates sister chromatid resolution during S phase

    PubMed Central

    Ono, Takao; Yamashita, Daisuke

    2013-01-01

    Condensins I and II are multisubunit complexes that play essential yet distinct functions in chromosome condensation and segregation in mitosis. Unlike condensin I, condensin II localizes to the nucleus during interphase, but it remains poorly understood what functions condensin II might have before mitotic entry. Here, we report that condensin II changes its chromatin-binding property during S phase. Remarkably, advanced premature chromosome condensation (PCC) assays enabled us to visualize condensin II forming “sister axes” in replicated regions of chromosomes in S phase cells. Depletion of condensin II compromised PCC-driven sister chromatid resolution during S phase. Moreover, fluorescence in situ hybridization assays revealed that condensin II, but not condensin I, promotes disjoining duplicated chromosomal loci during S phase. Application of mild replicative stress partially impaired this process and further exacerbated phenotypes arising from condensin II depletion. Our results suggest that condensin II initiates structural reorganization of duplicated chromosomes during S phase to prepare for their proper condensation and segregation in mitosis. PMID:23401001

  7. X-linked mental retardation syndrome: Three brothers with the Brooks-Wisniewski-Brown syndrome

    SciTech Connect

    Morava, E.; Storcz, J.; Kosztolanyi, G.

    1996-07-12

    We report on 3 brothers with growth and mental retardation, bifrontal narrowness, short palpebral fissures, deeply set eyes with entropion, wide bulbous nose, small mouth, myopia, and spastic diplegia. The patients were born to normal and non-consanguineous parents. The similarity of our cases with those recently reported by Brooks et al. supports their suggestion that these patients are representative of a distinct entity. 8 refs., 3 figs., 1 tab.

  8. Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei

    PubMed Central

    Senaratne, T. Niroshini; Joyce, Eric F.; Wu, C.-ting

    2016-01-01

    Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division. This important function involves an evolutionarily conserved protein complex known as cohesin; any loss of cohesin causes premature sister chromatid separation in mitosis. Here, we examined the role of cohesin in sister chromatid cohesion prior to mitosis, using fluorescence in situ hybridization (FISH) to assay the alignment of sister chromatids in interphase Drosophila cells. Surprisingly, we found that sister chromatid cohesion can be maintained in G2 with little to no cohesin. This capacity to maintain cohesion is widespread in Drosophila, unlike in other systems where a reduced dependence on cohesin for sister chromatid segregation has been observed only at specific chromosomal regions, such as the rDNA locus in budding yeast. Additionally, we show that condensin II antagonizes the alignment of sister chromatids in interphase, supporting a model wherein cohesin and condensin II oppose each other’s functions in the alignment of sister chromatids. Finally, because the maternal and paternal homologs are paired in the somatic cells of Drosophila, and because condensin II has been shown to antagonize this pairing, we consider the possibility that condensin II-regulated mechanisms for aligning homologous chromosomes may also contribute to sister chromatid cohesion. PMID:27541002

  9. Investigating the Interplay between Sister Chromatid Cohesion and Homolog Pairing in Drosophila Nuclei.

    PubMed

    Senaratne, T Niroshini; Joyce, Eric F; Nguyen, Son C; Wu, C-Ting

    2016-08-01

    Following DNA replication, sister chromatids must stay connected for the remainder of the cell cycle in order to ensure accurate segregation in the subsequent cell division. This important function involves an evolutionarily conserved protein complex known as cohesin; any loss of cohesin causes premature sister chromatid separation in mitosis. Here, we examined the role of cohesin in sister chromatid cohesion prior to mitosis, using fluorescence in situ hybridization (FISH) to assay the alignment of sister chromatids in interphase Drosophila cells. Surprisingly, we found that sister chromatid cohesion can be maintained in G2 with little to no cohesin. This capacity to maintain cohesion is widespread in Drosophila, unlike in other systems where a reduced dependence on cohesin for sister chromatid segregation has been observed only at specific chromosomal regions, such as the rDNA locus in budding yeast. Additionally, we show that condensin II antagonizes the alignment of sister chromatids in interphase, supporting a model wherein cohesin and condensin II oppose each other's functions in the alignment of sister chromatids. Finally, because the maternal and paternal homologs are paired in the somatic cells of Drosophila, and because condensin II has been shown to antagonize this pairing, we consider the possibility that condensin II-regulated mechanisms for aligning homologous chromosomes may also contribute to sister chromatid cohesion. PMID:27541002

  10. Big Questions: Missing Antimatter

    SciTech Connect

    Lincoln, Don

    2013-08-27

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  11. Big data in biomedicine.

    PubMed

    Costa, Fabricio F

    2014-04-01

    The increasing availability and growth rate of biomedical information, also known as 'big data', provides an opportunity for future personalized medicine programs that will significantly improve patient care. Recent advances in information technology (IT) applied to biomedicine are changing the landscape of privacy and personal information, with patients getting more control of their health information. Conceivably, big data analytics is already impacting health decisions and patient care; however, specific challenges need to be addressed to integrate current discoveries into medical practice. In this article, I will discuss the major breakthroughs achieved in combining omics and clinical health data in terms of their application to personalized medicine. I will also review the challenges associated with using big data in biomedicine and translational science. PMID:24183925

  12. Bayesian big bang

    NASA Astrophysics Data System (ADS)

    Daum, Fred; Huang, Jim

    2011-09-01

    We show that the flow of particles corresponding to Bayes' rule has a number of striking similarities with the big bang, including cosmic inflation and cosmic acceleration. We derive a PDE for this flow using a log-homotopy from the prior probability density to the posteriori probability density. We solve this PDE using the gradient of the solution to Poisson's equation, which is computed using an exact Green's function and the standard Monte Carlo approximation of integrals. The resulting flow is analogous to Coulomb's law in electromagnetics. We have used no physics per se to derive this flow, but rather we have only used Bayes' rule and the definition of normalized probability and a loghomotopy parameter that could be interpreted as time. The details of this big bang resemble very recent theories much more closely than the so-called new inflation models, which postulate enormous inflation immediately after the big bang.

  13. Big Questions: Missing Antimatter

    ScienceCinema

    Lincoln, Don

    2014-08-07

    Einstein's equation E = mc2 is often said to mean that energy can be converted into matter. More accurately, energy can be converted to matter and antimatter. During the first moments of the Big Bang, the universe was smaller, hotter and energy was everywhere. As the universe expanded and cooled, the energy converted into matter and antimatter. According to our best understanding, these two substances should have been created in equal quantities. However when we look out into the cosmos we see only matter and no antimatter. The absence of antimatter is one of the Big Mysteries of modern physics. In this video, Fermilab's Dr. Don Lincoln explains the problem, although doesn't answer it. The answer, as in all Big Mysteries, is still unknown and one of the leading research topics of contemporary science.

  14. Increased sister chromatid exchange associated with smoking and coffee consumption.

    PubMed

    Reidy, J A; Annest, J L; Chen, A T; Welty, T K

    1988-01-01

    Sister chromatid exchange (SCE) is a very sensitive cytogenetic assay for detecting exposure to chemical mutagens and carcinogens. One application of SCE is the monitoring of populations believed to be exposed to such agents. We have, however, relatively little knowledge about common lifestyle factors that may influence SCE and therefore complicate any study designed to examine the effects of exposure to genotoxins. In this study, we assessed the effect of cigarette smoking and coffee consumption on SCE. Smoking was associated with an increase of approximately 2 SCEs per cell and a decrease in cell proliferation. A positive linear relationship between SCE and coffee consumption was also observed. This effect was similar for smokers and nonsmokers. Additionally, the folic acid content of cell culture medium seemed to affect neither SCE nor cell proliferation. PMID:3169009

  15. Sister chromatid exchanges in peripheral lymphocytes after preoperative mammography

    SciTech Connect

    Husum, B.; Wulf, H.C.; Niebuhr, E.

    1981-09-01

    Examination of sister chromatid exchanges (SCE) in peripheral lymphocytes may be useful for evaluating in vivo exposure to chemical mutagens. In vitro exposure of human lymphocytes to low levels of ionizing radiation has failed to produce increased SCE rates. Scarcity of information about the SCE test system and in vivo exposure to radiation prompted the present study of SCE rates in peripheral lymphocytes in women investigated with mammography prior to operation because of a tumor of the breast. In 64 of a total of 131 women a mammography was performed before the operation. The two groups of patients were identical with respect to age, smoking habits, and incidence of malignancy of the mammary tumors. SCE rates were examined in 30 metaphases from each patient following cultivation of peripheral blood lymphocytes using the BrdU/Giemsa technique.

  16. Bold vision: Catholic sisters and the creation of American hospitals.

    PubMed

    Levin, Peter J

    2011-06-01

    American hospitals were started by religious, ethnic and community groups to serve local health care needs. Immigration into the eastern cities and the constant movement west of the frontier required the creation of educational and service facilities to serve these populations and localities. In the nineteenth century, Catholic sisters went all across the country establishing schools and hospitals. They were motivated to care for the sick, establish charitable institutions and spread their religious beliefs. Their impact on the development of the American health system was enormous. They also supported the importance of nursing for the provision of scientifically based medical care and created schools of nursing. Their historical record as founders, builders, financiers and managers of hospitals is unmatched by any other group between 1850 and 1950. And, this was accomplished at a time when women played no similar leadership and institutional ownership role elsewhere in society. PMID:21452027

  17. Telomere sister chromatid exchange in telomerase deficient murine cells

    SciTech Connect

    Wang, Yisong; Giannone, Richard J; Liu, Yie

    2005-01-01

    We have recently demonstrated that several types of genomic rearrangements (i.e., telomere sister chromatid exchange (T-SCE), genomic-SCE, or end-to-end fusions) were more often detected in long-term cultured murine telomerase deficient embryonic stem (ES) cells than in freshly prepared murine splenocytes, even through they possessed similar frequencies of critically short telomeres. The high rate of genomic rearrangements in telomerase deficient ES cells, when compared to murine splenocytes, may reflect the cultured cells' gained ability to protect chromosome ends with eroded telomeres allowing them to escape 'end crisis'. However, the possibility that ES cells were more permissive to genomic rearrangements than other cell types or that differences in the microenvironment or genetic background of the animals might consequentially determine the rate of T-SCEs or other genomic rearrangements at critically short telomeres could not be ruled out.

  18. Transcription facilitates sister chromatid cohesion on chromosomal arms.

    PubMed

    Bhardwaj, Shweta; Schlackow, Margarita; Rabajdova, Miroslava; Gullerova, Monika

    2016-08-19

    Cohesin is a multi-subunit protein complex essential for sister chromatid cohesion, gene expression and DNA damage repair. Although structurally well studied, the underlying determinant of cohesion establishment on chromosomal arms remains enigmatic. Here, we show two populations of functionally distinct cohesin on chromosomal arms using a combination of genomics and single-locus specific DNA-FISH analysis. Chromatin bound cohesin at the loading sites co-localizes with Pds5 and Eso1 resulting in stable cohesion. In contrast, cohesin independent of its loader is unable to maintain cohesion and associates with chromatin in a dynamic manner. Cohesive sites coincide with highly expressed genes and transcription inhibition leads to destabilization of cohesin on chromatin. Furthermore, induction of transcription results in de novo recruitment of cohesive cohesin. Our data suggest that transcription facilitates cohesin loading onto chromosomal arms and is a key determinant of cohesive sites in fission yeast. PMID:27084937

  19. Mercury poisoning in two 13-year-old twin sisters.

    PubMed

    Khodashenas, Ezzat; Aelami, Mohammadhassan; Balali-Mood, Mahdi

    2015-03-01

    Mercury (Hg) is a toxic agent that evaporates in room temperature and its inhalation may cause poisoning. Due to the nonspecific symptoms, diagnosis is difficult in special circumstances with no initial history of Hg exposure. We report two such cases of Hg poisoning. The patients were two sisters, presenting with pain in extremities, itchy rashes, sweating, salivation, weakness, and mood changes. They have used a compound that contains mercury, for treatment of pedicullosis three months before admission. This compound was purchased from a herbal shop and was applied locally on the scalps for 2 days. Their urinary mercury concentrations were 50 and 70 mg/L. They were successfully treated by D-penicillamine and gabapentin. In a patient with any kind of bone and joint pain, skin rash erythema and peripheral neuropathy, mercury poisoning should be considered as a differential diagnosis. PMID:26109979

  20. A Big Bang Lab

    ERIC Educational Resources Information Center

    Scheider, Walter

    2005-01-01

    The February 2005 issue of The Science Teacher (TST) reminded everyone that by learning how scientists study stars, students gain an understanding of how science measures things that can not be set up in lab, either because they are too big, too far away, or happened in a very distant past. The authors of "How Far are the Stars?" show how the…

  1. Big-City Rules

    ERIC Educational Resources Information Center

    Gordon, Dan

    2011-01-01

    When it comes to implementing innovative classroom technology programs, urban school districts face significant challenges stemming from their big-city status. These range from large bureaucracies, to scalability, to how to meet the needs of a more diverse group of students. Because of their size, urban districts tend to have greater distance…

  2. Big Enough for Everyone?

    ERIC Educational Resources Information Center

    Coote, Anna

    2010-01-01

    The UK's coalition government wants to build a "Big Society." The Prime Minister says "we are all in this together" and building it is the responsibility of every citizen as well as every government department. The broad vision is welcome, but everything depends on how the vision is translated into policy and practice. The government aims to put…

  3. The big bang

    NASA Astrophysics Data System (ADS)

    Silk, Joseph

    Our universe was born billions of years ago in a hot, violent explosion of elementary particles and radiation - the big bang. What do we know about this ultimate moment of creation, and how do we know it? Drawing upon the latest theories and technology, this new edition of The big bang, is a sweeping, lucid account of the event that set the universe in motion. Joseph Silk begins his story with the first microseconds of the big bang, on through the evolution of stars, galaxies, clusters of galaxies, quasars, and into the distant future of our universe. He also explores the fascinating evidence for the big bang model and recounts the history of cosmological speculation. Revised and updated, this new edition features all the most recent astronomical advances, including: Photos and measurements from the Hubble Space Telescope, Cosmic Background Explorer Satellite (COBE), and Infrared Space Observatory; the latest estimates of the age of the universe; new ideas in string and superstring theory; recent experiments on neutrino detection; new theories about the presence of dark matter in galaxies; new developments in the theory of the formation and evolution of galaxies; the latest ideas about black holes, worm holes, quantum foam, and multiple universes.

  4. Thinking Big, Aiming High

    ERIC Educational Resources Information Center

    Berkeley, Viv

    2010-01-01

    What do teachers, providers and policymakers need to do in order to support disabled learners to "think big and aim high"? That was the question put to delegates at NIACE's annual disability conference. Some clear themes emerged, with delegates raising concerns about funding, teacher training, partnership-working and employment for disabled…

  5. The Big Empty.

    ERIC Educational Resources Information Center

    Brook, Richard; Smith, Shelley; Tisdale, Mary

    1995-01-01

    Discusses "The Big Empty" or, the Great Basin. Suggests that it is not empty but rather a great ecosystem rich in plants, animals, and minerals. Presents information and activities to guide students in exploring the Great Basin in order to understand the ways in which such an arid and seemingly harsh environment can support so many living things.…

  6. A Sobering Big Idea

    ERIC Educational Resources Information Center

    Wineburg, Sam

    2006-01-01

    Since Susan Adler, Alberta Dougan, and Jesus Garcia like "big ideas," the author offers one to ponder: young people in this country can not read with comprehension. The saddest thing about this crisis is that it is no secret. The 2001 results of the National Assessment of Educational Progress (NAEP) for reading, published in every major newspaper,…

  7. The Big Fish

    ERIC Educational Resources Information Center

    DeLisle, Rebecca; Hargis, Jace

    2005-01-01

    The Killer Whale, Shamu jumps through hoops and splashes tourists in hopes for the big fish, not because of passion, desire or simply the enjoyment of doing so. What would happen if those fish were obsolete? Would this killer whale be able to find the passion to continue to entertain people? Or would Shamu find other exciting activities to do…

  8. Big Bang Theory

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    The theory which asserts that the universe originated a finite time ago by expanding from an infinitely compressed state. According to this model, space, time and matter originated together, and the universe has been expanding ever since. Key stages in the history of the Big Bang universe are summarized below....

  9. The Big Sky inside

    ERIC Educational Resources Information Center

    Adams, Earle; Ward, Tony J.; Vanek, Diana; Marra, Nancy; Hester, Carolyn; Knuth, Randy; Spangler, Todd; Jones, David; Henthorn, Melissa; Hammill, Brock; Smith, Paul; Salisbury, Rob; Reckin, Gene; Boulafentis, Johna

    2009-01-01

    The University of Montana (UM)-Missoula has implemented a problem-based program in which students perform scientific research focused on indoor air pollution. The Air Toxics Under the Big Sky program (Jones et al. 2007; Adams et al. 2008; Ward et al. 2008) provides a community-based framework for understanding the complex relationship between poor…

  10. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  11. Addressing the Apparent Paradox of the Catholic Sister Principal: 1940-1965

    ERIC Educational Resources Information Center

    O'Donoghue, Tom; Harford, Judith

    2013-01-01

    A body of scholarship on the history of the lives of Catholic teaching sisters has thrown up various challenges to educational historians. One challenge can be posed by asking how teaching sisters were able to go on to take up leadership positions. This is prompted by the observation that a particular body of literature for the period 1940-1965…

  12. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  13. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  14. 40 CFR 79.65 - In vivo sister chromatid exchange assay.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... references should be consulted. (1) 40 CFR 798.5915, In vivo Sister Chromatid Exchange Assay. (2) Kato, H...) assay detects the ability of a chemical to enhance the exchange of DNA between two sister chromatids of... ligation of at least two DNA helices. (c) Test method—(1) Principle of the test method. (i) Groups...

  15. Business and Science - Big Data, Big Picture

    NASA Astrophysics Data System (ADS)

    Rosati, A.

    2013-12-01

    Data Science is more than the creation, manipulation, and transformation of data. It is more than Big Data. The business world seems to have a hold on the term 'data science' and, for now, they define what it means. But business is very different than science. In this talk, I address how large datasets, Big Data, and data science are conceptually different in business and science worlds. I focus on the types of questions each realm asks, the data needed, and the consequences of findings. Gone are the days of datasets being created or collected to serve only one purpose or project. The trick with data reuse is to become familiar enough with a dataset to be able to combine it with other data and extract accurate results. As a Data Curator for the Advanced Cooperative Arctic Data and Information Service (ACADIS), my specialty is communication. Our team enables Arctic sciences by ensuring datasets are well documented and can be understood by reusers. Previously, I served as a data community liaison for the North American Regional Climate Change Assessment Program (NARCCAP). Again, my specialty was communicating complex instructions and ideas to a broad audience of data users. Before entering the science world, I was an entrepreneur. I have a bachelor's degree in economics and a master's degree in environmental social science. I am currently pursuing a Ph.D. in Geography. Because my background has embraced both the business and science worlds, I would like to share my perspectives on data, data reuse, data documentation, and the presentation or communication of findings. My experiences show that each can inform and support the other.

  16. Big Data and Chemical Education

    ERIC Educational Resources Information Center

    Pence, Harry E.; Williams, Antony J.

    2016-01-01

    The amount of computerized information that organizations collect and process is growing so large that the term Big Data is commonly being used to describe the situation. Accordingly, Big Data is defined by a combination of the Volume, Variety, Velocity, and Veracity of the data being processed. Big Data tools are already having an impact in…

  17. Unusual presentation of two Chinese phenylketonuria sisters who were misdiagnosed for years

    PubMed Central

    Liu, Xiaomei; Guo, Hui; Dahal, Mahesh; Shi, Bingyin

    2013-01-01

    Significant developmental delay was first noticed when both sisters were in their third year of life. However, no biochemical disorders were found through the routine biochemical tests, including liver and kidney function, lipoprotein, urine and blood cell count analysis. Progressively, both sisters exhibited odd behaviour, accompanied by personality changes and altered sleep rhythm and then were diagnosed as attention deficit hyperactivity disorder. In the eighth year, the younger sister began to take risperidone due to a presumed psychiatric disorder. Four months before attending our hospital, both sisters were diagnosed by MRI as having hereditary leukodystrophy. Nerve-nurturing treatment was tried, but without good outcome. They were then referred to our hospital for further consultation. After systematic examinations, it was confirmed that both the sisters were suffering from phenylketonuria. The symptoms were alleviated after dietary restriction of phenylalanine and symptomatic treatment. PMID:24068375

  18. Mitochondrial neurogastrointestinal encephalomyopathy: novel pathogenic mutations in thymidine phosphorylase gene in two Italian brothers.

    PubMed

    Libernini, Laura; Lupis, Chiara; Mastrangelo, Mario; Carrozzo, Rosalba; Santorelli, Filippo Maria; Inghilleri, Maurizio; Leuzzi, Vincenzo

    2012-08-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE, MIM 603041) is an autosomal recessive multisystem disorder occurring due to mutations in a nuclear gene coding for the enzyme thymidine phosphorylase (TYMP). Clinical features of MNGIE include gastrointestinal dysmotility, cachexia, ptosis or ophthalmoparesis, peripheral neuropathy, diffuse leukoencephalopathy, and signs of mitochondrial dysfunction in tissues. We report the clinical and molecular findings in two brothers in whom novel TYMP gene mutations (c.215-13_215delinsGCGTGA; c.1159 + 2T > A) were associated with different clinical presentations and outcomes. PMID:22618301

  19. Transmission of the fra(X) haplotype from three nonpenetrant brothers to their affected grandsons.

    PubMed

    Kirkilionis, A J; Chudley, A E; Greenberg, C R; Yan, D L; McGillivray, B; Hamerton, J L

    1992-06-01

    We report on a family showing transmission of the fra(X) gene by 3 nonpenetrant, fra(X) negative, normally intelligent, full and half-brothers to their affected grandsons. The mothers of the affected boys are obligate carriers, fra(X) negative, and of normal intelligence. This family illustrates the "Sherman Paradox" and is compatible with the predictions of the Laird X-inactivation imprinting model. In addition, molecular and/or cytogenetic studies have enabled at-risk relatives to learn more about their carrier fra(X) status and have allowed for more accurate genetic counselling. PMID:1605253

  20. Fatal familial insomnia: clinical and pathologic heterogeneity in genetic half brothers.

    PubMed

    Johnson, M D; Vnencak-Jones, C L; McLean, M J

    1998-12-01

    We describe clinical and pathologic features of a patient with fatal familial insomnia (FFI) whose prion (PrP) genotype is D178N coupled with methionine at codon 129 on his mutant allele and valine at codon 129 on his normal allele. A cousin (genetic half brother) with identical PrP genotypes exhibited strikingly different clinical and pathologic changes. Comparison of these cousins shows the phenotypic heterogeneity of FFI and suggests that the phenotypic expression of D178N is influenced by multiple factors. PMID:9855529

  1. 'The story of Abraham, Isaac and Jacob" or "am I my brother's keeper?".

    PubMed

    Oz, Carla; Zamir, Ashira; Gafny, Ron; Motro, Uzi

    2003-01-01

    Presented is a case report of a violent sexual assault where the DNA profile obtained from an item of evidence was compared to a suspect's profile. The profiles did not match, but the sharing of such a large number of alleles raised the suspicion that perhaps the real perpetrator was a blood relative of the suspect. The investigators requested a sample from the suspect's brother, and a match was defined. In an era of technological breakthroughs in the field of forensic DNA analysis, the importance of the scientist's attention to the evidence presented in each case is stressed. PMID:12570215

  2. Big3. Editorial

    PubMed Central

    Lehmann, Christoph U.; Séroussi, Brigitte; Jaulent, Marie-Christine

    2014-01-01

    Summary Objectives To provide an editorial introduction into the 2014 IMIA Yearbook of Medical Informatics with an overview of the content, the new publishing scheme, and upcoming 25th anniversary. Methods A brief overview of the 2014 special topic, Big Data - Smart Health Strategies, and an outline of the novel publishing model is provided in conjunction with a call for proposals to celebrate the 25th anniversary of the Yearbook. Results ‘Big Data’ has become the latest buzzword in informatics and promise new approaches and interventions that can improve health, well-being, and quality of life. This edition of the Yearbook acknowledges the fact that we just started to explore the opportunities that ‘Big Data’ will bring. However, it will become apparent to the reader that its pervasive nature has invaded all aspects of biomedical informatics – some to a higher degree than others. It was our goal to provide a comprehensive view at the state of ‘Big Data’ today, explore its strengths and weaknesses, as well as its risks, discuss emerging trends, tools, and applications, and stimulate the development of the field through the aggregation of excellent survey papers and working group contributions to the topic. Conclusions For the first time in history will the IMIA Yearbook be published in an open access online format allowing a broader readership especially in resource poor countries. For the first time, thanks to the online format, will the IMIA Yearbook be published twice in the year, with two different tracks of papers. We anticipate that the important role of the IMIA yearbook will further increase with these changes just in time for its 25th anniversary in 2016. PMID:24853037

  3. Small turbines, big unknown

    SciTech Connect

    Gipe, P.

    1995-07-01

    While financial markets focus on the wheeling and dealing of the big wind companies, the small wind turbine industry quietly keeps churning out its smaller but effective machines. Some, the micro turbines, are so small they can be carried by hand. Though worldwide sales of small wind turbines fall far short of even one large windpower plant, figures reach $8 million to $10 million annually and could be as much as twice that if batteries and engineering services are included.

  4. The Next Big Idea

    PubMed Central

    2013-01-01

    Abstract George S. Eisenbarth will remain in our memories as a brilliant scientist and great collaborator. His quest to discover the cause and prevention of type 1 (autoimmune) diabetes started from building predictive models based on immunogenetic markers. Despite his tremendous contributions to our understanding of the natural history of pre-type 1 diabetes and potential mechanisms, George left us with several big questions to answer before his quest is completed. PMID:23786296

  5. Big Bear Solar Observatory

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    Big Bear Solar Observatory (BBSO) is located at the end of a causeway in a mountain lake more than 2 km above sea level. The site has more than 300 sunny days a year and a natural inversion caused by the lake which makes for very clean images. BBSO is the only university observatory in the US making high-resolution observations of the Sun. Its daily images are posted at http://www.bbso.njit.e...

  6. DARPA's Big Mechanism program.

    PubMed

    Cohen, Paul R

    2015-07-01

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers. PMID:26178259

  7. DARPA's Big Mechanism program

    NASA Astrophysics Data System (ADS)

    Cohen, Paul R.

    2015-07-01

    Reductionist science produces causal models of small fragments of complicated systems. Causal models of entire systems can be hard to construct because what is known of them is distributed across a vast amount of literature. The Big Mechanism program aims to have machines read the literature and assemble the causal fragments found in individual papers into huge causal models, automatically. The current domain of the program is cell signalling associated with Ras-driven cancers.

  8. A holographic big bang?

    NASA Astrophysics Data System (ADS)

    Afshordi, N.; Mann, R. B.; Pourhasan, R.

    2015-11-01

    We present a cosmological model in which the Universe emerges out of the collapse of a five-dimensional (5D) star as a spherical three-brane. The initial singularity of the big bang becomes hidden behind a causal horizon. Near scale-invariant primordial curvature perturbations can be induced on the brane via a thermal atmosphere that is in equilibrium with the brane, circumventing the need for a separate inflationary process and providing an important test of the model.

  9. Big Bang Circus

    NASA Astrophysics Data System (ADS)

    Ambrosini, C.

    2011-06-01

    Big Bang Circus is an opera I composed in 2001 and which was premiered at the Venice Biennale Contemporary Music Festival in 2002. A chamber group, four singers and a ringmaster stage the story of the Universe confronting and interweaving two threads: how early man imagined it and how scientists described it. Surprisingly enough fancy, myths and scientific explanations often end up using the same images, metaphors and sometimes even words: a strong tension, a drumskin starting to vibrate, a shout…

  10. Big Sky Carbon Atlas

    DOE Data Explorer

    The Big Sky Carbon Atlas is an online geoportal designed for you to discover, interpret, and access geospatial data and maps relevant to decision support and education on carbon sequestration in the Big Sky Region. In serving as the public face of the Partnership's spatial Data Libraries, the Atlas provides a gateway to geographic information characterizing CO2 sources, potential geologic sinks, terrestrial carbon fluxes, civil and energy infrastructure, energy use, and related themes. In addition to directly serving the BSCSP and its stakeholders, the Atlas feeds regional data to the NatCarb Portal, contributing to a national perspective on carbon sequestration. Established components of the Atlas include a gallery of thematic maps and an interactive map that allows you to: • Navigate and explore regional characterization data through a user-friendly interface • Print your map views or publish them as PDFs • Identify technical references relevant to specific areas of interest • Calculate straight-line or pipeline-constrained distances from point sources of CO2 to potential geologic sink features • Download regional data layers (feature under development) (Acknowledgment to the Big Sky Carbon Sequestration Partnership (BSCSP); see home page at http://www.bigskyco2.org/)

  11. Big Data Technologies

    PubMed Central

    Bellazzi, Riccardo; Dagliati, Arianna; Sacchi, Lucia; Segagni, Daniele

    2015-01-01

    The so-called big data revolution provides substantial opportunities to diabetes management. At least 3 important directions are currently of great interest. First, the integration of different sources of information, from primary and secondary care to administrative information, may allow depicting a novel view of patient’s care processes and of single patient’s behaviors, taking into account the multifaceted nature of chronic care. Second, the availability of novel diabetes technologies, able to gather large amounts of real-time data, requires the implementation of distributed platforms for data analysis and decision support. Finally, the inclusion of geographical and environmental information into such complex IT systems may further increase the capability of interpreting the data gathered and extract new knowledge from them. This article reviews the main concepts and definitions related to big data, it presents some efforts in health care, and discusses the potential role of big data in diabetes care. Finally, as an example, it describes the research efforts carried on in the MOSAIC project, funded by the European Commission. PMID:25910540

  12. X-inactivation in the clinical phenotype of fragile X premutation carrier sisters

    PubMed Central

    Robertson-Dick, Erin E.; O'Keefe, Joan A.; Hadd, Andrew G.; Zhou, Lili; Berry-Kravis, Elizabeth

    2016-01-01

    Objective: The purpose of this study is to describe a case series of 4 sisters with discordant clinical phenotypes associated with fragile X–associated tremor/ataxia syndrome (FXTAS) that may be explained by varying CGG repeat sizes and activation ratios (ARs) (the ratio of cells carrying the normal fragile X mental retardation 1 [FMR1] allele on the active X chromosome). Methods: Four sisters with premutation size FMR1 gene repeats underwent detailed clinical characterization. CGG repeat length was determined by PCR, and AR was determined using a newly developed commercial methylation PCR assay and was compared with the results from Southern blot with densitometric image analysis. Results: Sister 1 had the largest CGG expansion (82) and the lowest AR (12%), with the most severe clinical presentation. Sister 2 had a lower CGG expansion (70) and an AR of 10% but had a milder clinical presentation.Sister 3 had a similar CGG expansion (79) but a slightly higher AR of 15% and less neurologic involvement. Sister 4 had a similar CGG expansion size of 80 but had the largest AR (40%) and was the only sister not to be affected by FXTAS or have any neurologic signs on examination. Conclusions: These results suggest that premutation carrier women who have higher ARs may be less likely to show manifestations of FXTAS. If larger studies show similar patterns, AR data could potentially be beneficial to supplement CGG repeat size when counseling premutation carrier women in the clinic. PMID:27066582

  13. The USA's nurse managers and UK's ward sisters: critical roles for empowerment.

    PubMed

    Cameron-Buccheri, R; Ogier, M E

    1994-07-01

    The nurse manager/ward sister role is becoming endangered as many of these nurses are being asked to take fiscal and personnel responsibility for multiple units/programmes and supervise more non-registered nursing staff. Loss of this important nurse manager/ward sister role could severely decrease nursing's voice in the development and implementation of policies that affect nurses and the care they deliver. The authors review 20 years of literature from both the USA and the UK regarding supportive supervision and the role of the nurse manager/ward sister. Nurse managers/ward sisters were found to be key individuals within the entire health-care organization. Nurse managers/ward sisters can empower the nurses they supervise to initiate changes that will improve patient care. Nurse managers/ward sisters can also improve the working conditions and thus increase the job satisfaction and retention of those they supervise. Strategies for being more supportive of these overworked and endangered nurse managers/ward sisters are suggested. PMID:8055167

  14. Sister chromatid resolution is an intrinsic part of chromosome organization in prophase.

    PubMed

    Nagasaka, Kota; Hossain, M Julius; Roberti, M Julia; Ellenberg, Jan; Hirota, Toru

    2016-06-01

    The formation of mitotic chromosomes requires both compaction of chromatin and the resolution of replicated sister chromatids. Compaction occurs during mitotic prophase and prometaphase, and in prophase relies on the activity of condensin II complexes. Exactly when and how sister chromatid resolution occurs has been largely unknown, as has its molecular requirements. Here, we established a method to visualize sister resolution by sequential replication labelling with two distinct nucleotide derivatives. Quantitative three-dimensional imaging then allowed us to measure the resolution of sister chromatids throughout mitosis by calculating their non-overlapping volume within the whole chromosome. Unexpectedly, we found that sister chromatid resolution starts already at the beginning of prophase, proceeds concomitantly with chromatin compaction and is largely completed by the end of prophase. Sister chromatid resolution was abolished by inhibition of topoisomerase IIα and by depleting or preventing mitotic activation of condensin II, whereas blocking cohesin dissociation from chromosomes had little effect. Mitotic sister chromatid resolution is thus an intrinsic part of mitotic chromosome formation in prophase that relies largely on DNA decatenation and shares the molecular requirement for condensin II with prophase compaction. PMID:27136266

  15. The geography and ecology of plant speciation: range overlap and niche divergence in sister species

    PubMed Central

    Anacker, Brian L.; Strauss, Sharon Y.

    2014-01-01

    A goal of evolutionary biology is to understand the roles of geography and ecology in speciation. The recent shared ancestry of sister species can leave a major imprint on their geographical and ecological attributes, possibly revealing processes involved in speciation. We examined how ecological similarity, range overlap and range asymmetry are related to time since divergence of 71 sister species pairs in the California Floristic Province (CFP). We found that plants exhibit strikingly different age-range correlation patterns from those found for animals; the latter broadly support allopatric speciation as the primary mode of speciation. By contrast, plant sisters in the CFP were sympatric in 80% of cases and range sizes of sisters differed by a mean of 10-fold. Range overlap and range asymmetry were greatest in younger sisters. These results suggest that speciation mechanisms broadly grouped under ‘budding’ speciation, in which a larger ranged progenitor gives rise to a smaller ranged derivative species, are probably common. The ecological and reproductive similarity of sisters was significantly greater than that of sister–non-sister congeners for every trait assessed. However, shifts in at least one trait were present in 93% of the sister pairs; habitat and soil shifts were especially common. Ecological divergence did not increase with range overlap contrary to expectations under character displacement in sympatry. Our results suggest that vicariant speciation is more ubiquitous in animals than plants, perhaps owing to the sensitivity of plants to fine-scale environmental heterogeneity. Despite high levels of range overlap, ecological shifts in the process of budding speciation may result in low rates of fine-scale spatial co-occurrence. These results have implications for ecological studies of trait evolution and community assembly; despite high levels of sympatry, sister taxa and potentially other close relatives, may be missing from local communities

  16. The SUMO deconjugating peptidase Smt4 contributes to the mechanism required for transition from sister chromatid arm cohesion to sister chromatid pericentromere separation.

    PubMed

    Stephens, Andrew D; Snider, Chloe E; Bloom, Kerry

    2015-01-01

    The pericentromere chromatin protrudes orthogonally from the sister-sister chromosome arm axis. Pericentric protrusions are organized in a series of loops with the centromere at the apex, maximizing its ability to interact with stochastically growing and shortening kinetochore microtubules. Each pericentromere loop is ∼50 kb in size and is organized further into secondary loops that are displaced from the primary spindle axis. Cohesin and condensin are integral to mechanisms of loop formation and generating resistance to outward forces from kinesin motors and anti-parallel spindle microtubules. A major unanswered question is how the boundary between chromosome arms and the pericentromere is established and maintained. We used sister chromatid separation and dynamics of LacO arrays distal to the pericentromere to address this issue. Perturbation of chromatin spring components results in 2 distinct phenotypes. In cohesin and condensin mutants sister pericentric LacO arrays separate a defined distance independent of spindle length. In the absence of Smt4, a peptidase that removes SUMO modifications from proteins, pericentric LacO arrays separate in proportion to spindle length increase. Deletion of Smt4, unlike depletion of cohesin and condensin, causes stretching of both proximal and distal pericentromere LacO arrays. The data suggest that the sumoylation state of chromatin topology adjusters, including cohesin, condensin, and topoisomerase II in the pericentromere, contribute to chromatin spring properties as well as the sister cohesion boundary. PMID:25946564

  17. Wild female baboons bias their social behaviour towards paternal half-sisters.

    PubMed Central

    Smith, Kerri; Alberts, Susan C; Altmann, Jeanne

    2003-01-01

    Adult female cercopithecines have long been known to bias their social behaviour towards close maternal kin. However, much less is understood about the behaviour of paternal kin, especially in wild populations. Here, we show that wild adult female baboons bias their affiliative behaviour towards their adult paternal half-sisters in the same manner and to the same extent that they bias their behaviour towards adult maternal half-sisters. Females appear to rely heavily on social familiarity as a means of biasing their behaviour towards paternal half-sisters, but may use phenotype matching as well. PMID:12641905

  18. Ecologically distinct dinosaurian sister group shows early diversification of Ornithodira.

    PubMed

    Nesbitt, Sterling J; Sidor, Christian A; Irmis, Randall B; Angielczyk, Kenneth D; Smith, Roger M H; Tsuji, Linda A

    2010-03-01

    The early evolutionary history of Ornithodira (avian-line archosaurs) has hitherto been documented by incomplete (Lagerpeton) or unusually specialized forms (pterosaurs and Silesaurus). Recently, a variety of Silesaurus-like taxa have been reported from the Triassic period of both Gondwana and Laurasia, but their relationships to each other and to dinosaurs remain a subject of debate. Here we report on a new avian-line archosaur from the early Middle Triassic (Anisian) of Tanzania. Phylogenetic analysis places Asilisaurus kongwe gen. et sp. nov. as an avian-line archosaur and a member of the Silesauridae, which is here considered the sister taxon to Dinosauria. Silesaurids were diverse and had a wide distribution by the Late Triassic, with a novel ornithodiran bauplan including leaf-shaped teeth, a beak-like lower jaw, long, gracile limbs, and a quadrupedal stance. Our analysis suggests that the dentition and diet of silesaurids, ornithischians and sauropodomorphs evolved independently from a plesiomorphic carnivorous form. As the oldest avian-line archosaur, Asilisaurus demonstrates the antiquity of both Ornithodira and the dinosaurian lineage. The initial diversification of Archosauria, previously documented by crocodilian-line archosaurs in the Anisian, can now be shown to include a contemporaneous avian-line radiation. The unparalleled taxonomic diversity of the Manda archosaur assemblage indicates that archosaur diversification was well underway by the Middle Triassic or earlier. PMID:20203608

  19. Two sisters in the same dress: Heliconius cryptic species

    PubMed Central

    2008-01-01

    Background Sister species divergence and reproductive isolation commonly results from ecological adaptation. In mimetic Heliconius butterflies, shifts in colour pattern contribute to pre- and post-mating reproductive isolation and are commonly correlated with speciation. Closely related mimetic species are therefore not expected, as they should lack several important sources of reproductive isolation. Results Here we present phenotypic, behavioral and genetic evidence for the coexistence of two sympatric 'cryptic' species near Florencia in the eastern Andes of Colombia that share the same orange rayed colour pattern. These represent H. melpomene malleti and a novel taxon in the H. cydno group, here designated as novel race of Heliconius timareta, Heliconius timareta florencia. No-choice mating experiments show that these sympatric forms have strong assortative mating (≈96%) despite great similarity in colour pattern, implying enhanced divergence in pheromonal signals. Conclusion We hypothesize that these species might have resulted from recent convergence in colour pattern, perhaps facilitated by hybrid introgression of wing pattern genes. PMID:19040737

  20. Cerebrotendinous xanthomatosis: molecular characterization of two Scandinavian sisters.

    PubMed

    Rystedt, E; Olin, M; Seyama, Y; Buchmann, M; Berstad, A; Eggertsen, G; Björkhem, I

    2002-09-01

    Cerebrotendinous xanthomatosis (CTX) is a hereditary disorder, which is inherited as an autosomally recessive disease, causing production of cholesterol and cholestanol xanthomas and mental retardation. The disease is caused by mutations in the gene for sterol 27-hydroxylase (CYP27A1). The only CTX patients diagnosed in Scandinavia are two Norwegian sisters from a consanguineous marriage. Here we have characterized the mutation and its functional consequences for the enzyme. Analysis of genomic DNA from cultured fibroblasts identified a base exchange C > T in position 1441, causing arginine at amino acid position 441 to be replaced by tryptophan. The same mutation was introduced by mutagenesis in the complimentary DNA (cDNA) for CYP27, ligated into the expression vector pcDNA4/HisMax and transfected into HEK293 cells. The mutated enzyme had less than 5% of the enzyme activity compared with the native enzyme. No abnormal catalytic products could be identified in the cell culture medium. Probably the mutation affects the haem binding within the holoenzyme. The mutation has also previously been reported in a Japanese family. This is the second example of a CTX-causing mutation that has been recognized in more than one population. PMID:12270007

  1. 'The Sister' in the early days of the NHS.

    PubMed

    Ellis, Harold

    2016-04-01

    All the readers of this journal will have read and heard about the ward and operating theatre sisters in 'the old days'. What were they really like, and what was it like to work with them in the hospitals of those far-off times? I entered the old Radcliffe Infirmary Oxford in the summer of 1945, just as World War II was drawing to a close, as a 19 year old student to start my clinical training. I then qualified in July 1948, the very month the NHS came into being, and started my surgical career as house surgeon. The Radcliffe was the only acute hospital in the town and dealt with all emergency admissions. In addition, we worked at the Churchill Hospital, then a hutted hospital, erected during the War to deal with Canadian military casualties and now handed over for civilian use. Elective orthopaedics was carried out at the Wingfield Morris Hospital, later the Nuffield Orthopaedic Centre. The patients here were mostly children with bone and joint tuberculosis or poliomyelitis. The Slade Isolation Hospital dealt with the infectious fevers; I was admitted there twice as a student, with first chicken pox and then measles, both caught from my patients! PMID:27290759

  2. Monozygotic twin sisters discordant for familial hemiplegic migraine

    PubMed Central

    2013-01-01

    Background The high concordance rate of migraine in monozygotic twin pairs has long been recognised. In the current study, we present a monozygotic twin pair discordant for familial hemiplegic migraine (FHM). Case presentations We evaluated 12 adult family members in 2012. The twin pair was separately examined by neurologists at different time points. Mutation screening was performed for known FHM-related genes. The monozygosity of the twins was verified. Eleven individuals had a history of migraine or paroxysmal neurological symptoms, including four patients with motor aura. No mutations were detected in the CACNA1A, ATP1A2, SCN1A, PRRT2 or NOTCH3 genes. The monozygotic twin sisters, aged 52, were discordant for age of onset, motor aura and neuropsychological aura (forced thinking). Overall, the family members presented a wide range of phenotypical features. Conclusions Familial hemiplegic migraine is a monogenic disorder that is distinct from migraine with typical aura. However, in certain families with motor aura, such as this one, it is possible that the most severe phenotype is caused by an unlikely combination of polygenic traits and non-genetic factors. In these kindreds, we propose that hemiplegic aura is only a severe and complex form of typical aura. PMID:24041236

  3. Pigmentary mosaicism of the hyperpigmented type in two half-brothers.

    PubMed

    Horn, Denise; Happle, Rudolf; Neitzel, Heidemarie; Kunze, Jürgen

    2002-09-15

    Pigmentary mosaicism is a heterogeneous cutaneous phenotype that is often associated with extracutaneous anomalies. It is widely accepted that these phenotypes arise de novo as a result of a postzygotic mutation, leading to a mosaic status of the embryo. In the vast majority of cases, the occurrence of pigmentary mosaicism is sporadic. We report two paternal half-brothers affected with pigmentary mosaicism of the hyperpigmented type. The hyperpigmentation in both patients is distributed along the lines of Blaschko. In addition, mental retardation, facial asymmetry, short stature, scoliosis, and short fingers with clinodactyly of the 5th digit were noted in one of them. Chromosome analysis in this 15-year-old patient demonstrated a mosaic 46,XY,dup(3)(p21.3;pter)/46,XY with 12% aberrant cells in lymphocytes and 2% in skin fibroblasts derived from a hyperpigmented area. His nine-year-old half-brother had similar systematized hyperpigmented skin lesions, macrocephaly, facial asymmetry, and clinodactyly of the 5th digit. Chromosome analysis of peripheral lymphocytes showed a normal karyotype 46,XY. A skin biopsy could not be obtained. So far, some familial cases of hypopigmentation along the lines of Blaschko have been reported, but familial occurrence of the hyperpigmented type of pigmentary mosaicism appears to be extremely unusual. It is difficult to establish a causal relationship with the chromosomal mosaicism as observed in patient 1. Paradominant transmission seems unlikely because this would likewise imply that the chromosomal mosaicism is an incidental finding. PMID:12239723

  4. Familial appearance of congenital penile curvature – case history of two brothers

    PubMed Central

    Matuszewski, Marcin; Krajka, Kazimierz; Rębała, Krzysztof

    2013-01-01

    The true prevalence of congenital penile curvature (CPC) is difficult to determine. Some study reports suggests that this problem may occur in as many as 10% of the male population [1]. However, a literature search of the Medline database revealed no reference concerning familial appearance of congenital penile curvature. For that reason we would like to present our case series. Two brothers aged 25 and 26 respectively were admitted to the department of urology due to congenital penile curvature. Each patient was assessed by a history, physical examination, auto-photography of the erect penis, and a thorough sexual history. Concomitant anomalies of penile layers were absent in both cases. The Yachia [2] and Essed-Schroeder [3] corporoplasty technique were applied respectively. In follow-up both brothers reported straight erections. A survey of the fetal penis at different stages of development shows some degree of curvature in a considerable number of embryos [4]. Penile curvature may thus be considered almost physiological in embryos between 35 and 45 mm in length. Thus, it has also been proposed that penile curvature is secondary to an arrest in normal penile development [5]. Therefore, some form of congenital local androgen deficiency may be responsible for inherited penile curvature. PMID:24579033

  5. The association of infantile osteopetrosis and neuronal storage disease in two brothers.

    PubMed

    Jagadha, V; Halliday, W C; Becker, L E; Hinton, D

    1988-01-01

    Neurological manifestations in infantile osteopetrosis are common and varied, and not always attributable to the skeletal pathology. An unusual association of osteopetrosis with neuronal storage of ceroid lipofuscin is reported in two infant brothers born of nonconsanguinous parents. The first child became symptomatic at age 5 days with weight loss and vomiting. He had poor head control, hypertonia, and persistent fisting, and died at age 2 months. In the second infant, the diagnosis of osteopetrosis was confirmed at age 2 days. His neurological symptoms included blindness, deafness, and recurrent seizures. The infant died at 7 months of age. In both cases, autopsy confirmed the diffuse bony sclerosis with hepatosplenomegaly and extramedullary hematopoiesis. Neuropathological examination revealed cerebral atrophy with ventricular dilation, neuronal loss, and astrogliosis. The most striking finding was widespread accumulation of neuronal ceroid lipofuscin associated with formation of axonal spheroids. The optic nerves were compressed at the optic foramina and showed loss of myelinated axons and gliosis. Rapid Golgi impregnations of neurons from the calcarine cortex in the second infant were analyzed quantitatively, showing a reduction in the total dendritic length and number of branches. The primary defect in osteopetrosis is thought to be a lysosomal dysfunction involving the monocyte cell line from which osteoclasts are derived. Thus, the association in two brothers of osteopetrosis with accumulation of neuronal ceroid lipofuscin may not be fortuitous. The neuronal storage disorder in this instance probably reflects lysosomal dysfunction. PMID:3348081

  6. Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) in two Mexican brothers harboring a novel mutation in the ECGF1 gene.

    PubMed

    Monroy, Nancy; Macías Kauffer, Luis R; Mutchinick, Osvaldo M

    2008-01-01

    Mitochondrial neurogastrointestinal encephalomyopathy (MNGIE) is a rare autosomal recessive disease caused by mutations in the thymidine phosphorylase gene located on chromosome 22q13.32-ter, causing defective functioning of the enzyme. At present 87 sporadic or familial cases have been reported and 52 different mutations identified. We present herein the clinical, neuromuscular and molecular findings of two affected brothers from an indigenous Mexican family living in a very small village not far from Mexico City, both brothers being homozygous for a novel mutation (Leu133Pro) in exon 3 of the ECGF1 gene. PMID:18280229

  7. Are stepfathers' education levels associated with the intelligence of their stepsons? A register-based study of Norwegian half-brothers.

    PubMed

    Eriksen, Willy; Sundet, Jon M; Tambs, Kristian

    2013-05-01

    We examined the relationship between the parents' education levels and the adult intelligence of their children in a population-based, nationwide sample of Norwegian half-brothers with different fathers (2,016 pairs of half-brothers). In a family where the mother has two children with different men, the firstborn child usually lives with the younger child's father during a period of their childhood. This makes it possible to study the non-genetic effects of paternal education on children's development. Results showed that the education level of the younger half-brother's father was positively associated with the intelligence score of the older half-brother. The education level of the older half-brother's father was not associated with the intelligence score of the younger half-brother. Firstborn men whose half-brothers' fathers had high levels of education had intelligence scores that were 33% (95% confidence interval: 18-47%) of a standard deviation higher than those of firstborn men whose half-brothers' fathers had low levels of education, after adjustment for the biological fathers' education levels, mothers' education levels, and other background factors. These findings are compatible with the hypothesis that a child's family environment exerts an effect on the cognitive abilities of the child that lasts into adulthood. PMID:23560667

  8. Special Review of Smart Start Expenditures by Save Our Brothers, Inc. (Pittsboro, North Carolina) and Liberty Chapel United Church of Christ (Moncure, North Carolina).

    ERIC Educational Resources Information Center

    North Carolina Office of the State Auditor, Raleigh.

    This report of the Office of the State Auditor in North Carolina details audit findings regarding allegations of misuse of Smart Start funds by Save Our Brothers, Inc. and the Liberty Chapel United Church of Christ. Save Our Brothers, Inc., a nonprofit agency, received two contracts totaling $46,327 from the Chatham County Partnership for Children…

  9. The trashing of Big Green

    SciTech Connect

    Felten, E.

    1990-11-26

    The Big Green initiative on California's ballot lost by a margin of 2-to-1. Green measures lost in five other states, shocking ecology-minded groups. According to the postmortem by environmentalists, Big Green was a victim of poor timing and big spending by the opposition. Now its supporters plan to break up the bill and try to pass some provisions in the Legislature.

  10. How Big is Earth?

    NASA Astrophysics Data System (ADS)

    Thurber, Bonnie B.

    2015-08-01

    How Big is Earth celebrates the Year of Light. Using only the sunlight striking the Earth and a wooden dowel, students meet each other and then measure the circumference of the earth. Eratosthenes did it over 2,000 years ago. In Cosmos, Carl Sagan shared the process by which Eratosthenes measured the angle of the shadow cast at local noon when sunlight strikes a stick positioned perpendicular to the ground. By comparing his measurement to another made a distance away, Eratosthenes was able to calculate the circumference of the earth. How Big is Earth provides an online learning environment where students do science the same way Eratosthenes did. A notable project in which this was done was The Eratosthenes Project, conducted in 2005 as part of the World Year of Physics; in fact, we will be drawing on the teacher's guide developed by that project.How Big Is Earth? expands on the Eratosthenes project by providing an online learning environment provided by the iCollaboratory, www.icollaboratory.org, where teachers and students from Sweden, China, Nepal, Russia, Morocco, and the United States collaborate, share data, and reflect on their learning of science and astronomy. They are sharing their information and discussing their ideas/brainstorming the solutions in a discussion forum. There is an ongoing database of student measurements and another database to collect data on both teacher and student learning from surveys, discussions, and self-reflection done online.We will share our research about the kinds of learning that takes place only in global collaborations.The entrance address for the iCollaboratory is http://www.icollaboratory.org.

  11. A molecular test of alternative hypotheses of tetraodontiform (Acanthomorpha: Tetraodontiformes) sister group relationships using data from the RAG1 gene.

    PubMed

    Holcroft, Nancy I

    2004-09-01

    Two primary competing hypotheses regarding the identity of the sister group of the order Tetraodontiformes exist. The first hypothesis holds that some or all acanthuroid fishes represent the sister of Tetraodontiformes. The second, proposed in 1984 by Rosen, holds that the order Zeiformes is sister to Tetraodontiformes and that the family Caproidae is sister to this Zeiformes + Tetraodontiformes clade. These two hypotheses were tested using data from the single-copy nuclear gene RAG1. Representatives of most major orders of acanthomorph fishes were included to provide an appropriate context in which to place Tetraodontiformes and its hypothesized sister groups. The results of an unweighted parsimony analysis indicate that Zeiformes is not the sister group of Tetraodontiformes. In addition, Caproidae appears unrelated to Zeiformes. A monophyletic Tetraodontiformes was recovered as the sister group of the clade Ephippidae + Drepanidae and was more distantly related to the included zeiform and caproid representatives. PMID:15288052

  12. Sister Circles as a Culturally Relevant Intervention for Anxious African American Women

    PubMed Central

    Neal-Barnett, Angela; Stadulis, Robert; Murray, Marsheena; Payne, Margaret Ralston; Thomas, Anisha; Salley, Bernadette B.

    2011-01-01

    Research on anxiety treatment with African American women reveals a need to develop interventions that address factors relevant to their lives. Such factors include feelings of isolation, multiple roles undertaken by Black women, and faith. A recurrent theme across treatment studies is the importance of having support from other Black women. Sister circles are support groups that build upon existing friendships, fictive kin networks, and the sense of community found among African Americans females. Sister circles appear to offer many of the components Black women desire in an anxiety intervention. In this article, we explore sister circles as an intervention for anxious African American women. Culturally-infused aspects from our sister circle work with middle-class African American women are presented. Further research is needed. PMID:22081747

  13. Partial dosage compensation in Strepsiptera, a sister group of beetles.

    PubMed

    Mahajan, Shivani; Bachtrog, Doris

    2015-02-01

    Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila, downregulation of both X's in XX Caenorhabditis, or inactivation of one X in female mammals. In the flour beetle Tribolium, the X appears hyperexpressed in both sexes, which might represent the first of two steps to evolve dosage compensation along the paths mammals may have taken (i.e., upregulation of X in both sexes, followed by inactivation of one X in females). Here we test for dosage compensation in Strepsiptera, a sister taxon to beetles. We identify sex-linked chromosomes in Xenos vesparum based on genomic analysis of males and females, and show that its sex chromosome consists of two chromosomal arms in Tribolium: The X chromosome that is shared between Tribolium and Strepsiptera, and another chromosome that is autosomal in Tribolium and another distantly related Strepsiptera species, but sex-linked in X. vesparum. We use RNA-seq (RNA sequencing) to show that dosage compensation along the X of X. vesparum is partial and heterogeneous. In particular, genes that are X-linked in both beetles and Strepsiptera appear fully dosage compensated probably through downregulation in both sexes, whereas genes on the more recently added X segment have evolved only partial dosage compensation. In addition, reanalysis of published RNA-seq data suggests that Tribolium has evolved dosage compensation, without hypertranscribing the X in females. Our results demonstrate that patterns of dosage compensation are highly variable across sex-determination systems and even within species. PMID:25601100

  14. Partial Dosage Compensation in Strepsiptera, a Sister Group of Beetles

    PubMed Central

    Mahajan, Shivani; Bachtrog, Doris

    2015-01-01

    Sex chromosomes have evolved independently in many different taxa, and so have mechanisms to compensate for expression differences on sex chromosomes in males and females. Different clades have evolved vastly different ways to achieve dosage compensation, including hypertranscription of the single X in male Drosophila, downregulation of both X’s in XX Caenorhabditis, or inactivation of one X in female mammals. In the flour beetle Tribolium, the X appears hyperexpressed in both sexes, which might represent the first of two steps to evolve dosage compensation along the paths mammals may have taken (i.e., upregulation of X in both sexes, followed by inactivation of one X in females). Here we test for dosage compensation in Strepsiptera, a sister taxon to beetles. We identify sex-linked chromosomes in Xenos vesparum based on genomic analysis of males and females, and show that its sex chromosome consists of two chromosomal arms in Tribolium: The X chromosome that is shared between Tribolium and Strepsiptera, and another chromosome that is autosomal in Tribolium and another distantly related Strepsiptera species, but sex-linked in X. vesparum. We use RNA-seq (RNA sequencing) to show that dosage compensation along the X of X. vesparum is partial and heterogeneous. In particular, genes that are X-linked in both beetles and Strepsiptera appear fully dosage compensated probably through downregulation in both sexes, whereas genes on the more recently added X segment have evolved only partial dosage compensation. In addition, reanalysis of published RNA-seq data suggests that Tribolium has evolved dosage compensation, without hypertranscribing the X in females. Our results demonstrate that patterns of dosage compensation are highly variable across sex-determination systems and even within species. PMID:25601100

  15. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges

    PubMed Central

    Maeda, Junko; Yurkon, Charles R.; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A.; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A.

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140

  16. Solution Radioactivated by Hadron Radiation Can Increase Sister Chromatid Exchanges.

    PubMed

    Maeda, Junko; Yurkon, Charles R; Fujii, Yoshihiro; Fujisawa, Hiroshi; Kato, Sayaka; Brents, Colleen A; Uesaka, Mitsuru; Fujimori, Akira; Kitamura, Hisashi; Kato, Takamitsu A

    2015-01-01

    When energetic particles irradiate matter, it becomes activated by nuclear reactions. Radioactivation induced cellular effects are not clearly understood, but it could be a part of bystander effects. This investigation is aimed at understanding the biological effects from radioactivation in solution induced by hadron radiation. Water or phosphate buffered saline was activated by being exposed to hadron radiation including protons, carbon- and iron-ions. 1 mL of radioactivated solution was transferred to flasks with Chinese hamster ovary (CHO) cells cultured in 5 mL of complete media. The induction of sister chromatid exchanges (SCE) was used to observe any increase in DNA damage responses. The energy spectrum and the half-lives of the radioactivation were analyzed by NaI scintillation detector in order to identify generated radionuclides. In the radioactivated solution, 511 keV gamma-rays were observed, and their half-lives were approximately 2 min, 10 min, and 20 min. They respectively correspond to the beta+ decay of 15O, 13N, and 11C. The SCE frequencies in CHO cells increased depending on the amount of radioactivation in the solution. These were suppressed with a 2-hour delayed solution transfer or pretreatment with dimethyl sulfoxide (DMSO). Our results suggest that the SCE induction by radioactivated solution was mediated by free radicals produced by the annihilated gamma-rays. Since the SCE induction and DMSO modulation are also reported in radiation-induced bystander effects, our results imply that radioactivation of the solution may have some contribution to the bystander effects from hadron radiation. Further investigations are required to assess if radioactivation effects would attribute an additional level of cancer risk of the hadron radiation therapy itself. PMID:26657140

  17. Sister chromatid exchange assay as a predictor of tumor chemoresponse.

    PubMed

    Mourelatos, D

    2016-06-01

    Sister Chromatid Exchanges (SCEs) are known to enhance as a consequence of exposure to various mutagenic agents and appear to indicate DNA damaging effects and/or subsequent repair by homologous recombination (HR). DNA damage plays an interesting role in the majority of mechanisms underlying the effects of antitumor drugs, since the genetic activity of the plethora of these agents is due to their ability to damage the DNA. The DNA-effects of antitumor agents towards normal cells (genotoxicity) are great drawbacks of antitumor therapy and are connected to important adverse health effects in cancer patients undergoing chemotherapy. On the other hand, failure of chemotherapy in many cases is due to the DNA repair ability which cancer, like normal cells, also possess. As both DNA repair and genotoxic exposure are expected to vary among patients, correlating SCEs frequencies with only individual repair capacity may be feasible to predict. Cancer risk has not been observed to be associated with high SCEs levels. Since the administration of effective antitumor drugs with limited adverse effects is of great importance in the success of anticancer therapy, a lot of interest has been directed toward the development of methods and approaches that would enable the correct selection of appropriate drugs prior to the initiation of therapy on an individual basis. To this effect, more than 30 years ago, an investigation of the ability of the in vitro and the in vivo SCEs-assay to predict the in vitro and in vivo sensitivity of tumor cells to newly synthesized drugs or to those already in use began. In this short review a critical appraisal of the SCEs-assay as an important biomarker used for predicting cancer chemo-response as well as a summary of the key findings from several studies published within the last 20 years in this field is performed. PMID:27265374

  18. The dropped big toe.

    PubMed

    Satku, K; Wee, J T; Kumar, V P; Ong, B; Pho, R W

    1992-03-01

    Surgical procedures for exposure of the upper third of the fibula have been known to cause weakness of the long extensor of the big toe post-operatively. The authors present three representative cases of surgically induced dropped big toe. From cadaveric dissection, an anatomic basis was found for this phenomenon. The tibialis anterior and extensor digitorum longus muscles have their origin at the proximal end of the leg and receive their first motor innervation from a branch that arises from the common peroneal or deep peroneal nerve at about the level of the neck of the fibula. However, the extensor hallucis longus muscle originates in the middle one-third of the leg and the nerves innervating this muscle run a long course in close proximity to the fibula for up to ten centimeters from a level below the neck of the fibula before entering the muscle. Surgical intervention in the proximal one-third of the fibula just distal to the origin of the first motor branch to the tibialis anterior and extensor digitorum longus muscles carries a risk of injury to the nerves innervating the extensor hallucis longus. PMID:1519891

  19. Genomic data do not support comb jellies as the sister group to all other animals.

    PubMed

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-12-15

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the "Ctenophora-sister" hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data. PMID:26621703

  20. 3 CFR 8918 - Proclamation 8918 of December 17, 2012. Wright Brothers Day, 2012

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... their lifelong dream. Like so many Americans before and after them, these two men achieved the... mother, Susan—a gifted mathematician in her own right who challenged her children to think big and...

  1. The Prophet of Revealed Knowledge: Richard Brother, the Prince of the Hebrews and Nephew of the Almighty.

    ERIC Educational Resources Information Center

    Schamber, Jon F.; Stroud, Scott R.

    Seeking the answers as to what makes one speaker more charismatic than another and why some speeches are merely effective while others move audiences to a transcendent state is a difficult task. This paper follows up on this challenge and seeks to provide some answers as to how the prophetic works of Richard Brothers moved his followers to a…

  2. Think Big, Bigger ... and Smaller

    ERIC Educational Resources Information Center

    Nisbett, Richard E.

    2010-01-01

    One important principle of social psychology, writes Nisbett, is that some big-seeming interventions have little or no effect. This article discusses a number of cases from the field of education that confirm this principle. For example, Head Start seems like a big intervention, but research has indicated that its effects on academic achievement…

  3. The International Big History Association

    ERIC Educational Resources Information Center

    Duffy, Michael; Duffy, D'Neil

    2013-01-01

    IBHA, the International Big History Association, was organized in 2010 and "promotes the unified, interdisciplinary study and teaching of history of the Cosmos, Earth, Life, and Humanity." This is the vision that Montessori embraced long before the discoveries of modern science fleshed out the story of the evolving universe. "Big History" is a…

  4. The Big Read: Case Studies

    ERIC Educational Resources Information Center

    National Endowment for the Arts, 2009

    2009-01-01

    The Big Read evaluation included a series of 35 case studies designed to gather more in-depth information on the program's implementation and impact. The case studies gave readers a valuable first-hand look at The Big Read in context. Both formal and informal interviews, focus groups, attendance at a wide range of events--all showed how…

  5. Whole Language Using Big Books.

    ERIC Educational Resources Information Center

    Whyte, Sarah

    Designed as thematic units around Wright Company Big Books, the lessons in this guide demonstrate ways that Big Books can be used in a whole language first grade program. Each lesson indicates skill focus, needed materials, procedures, and additional thoughts or suggestions about the lesson. Units consist of: "Bedtime" (five lessons); "Monsters…

  6. Brief report: comparative ABA and DIR trials in twin brothers with autism.

    PubMed

    Hilton, Jane C; Seal, Brenda C

    2007-07-01

    Trial interventions in DIR and ABA with twin brothers with autism were offered to help the parents choose one of the programs for their sons. Pre- and post-test scores on the Communication and Symbolic Behavior Scales (CSBS) revealed a slight gain in the composite score of the ABA child and a slight loss in the score of the DIR child. Contrasted gains and losses occurred in six of the seven CSBS clusters. Results from this pilot research are discussed with additional communication and behavior data from the intervention period. Careful interpretation of CSBS outcomes in counseling parents and graduate students is strongly advised. Continued research in comparative outcomes for intervention programs is strongly encouraged. PMID:17072747

  7. Two Brothers with Bardet-Biedl Syndrome Presenting with Chronic Renal Failure

    PubMed Central

    Sahin, Cem; Huddam, Bulent; Akbaba, Gulhan; Tunca, Hasan; Koca, Emine; Levent, Mustafa

    2015-01-01

    Bardet-Biedl Syndrome (BBS) is a rarely seen autosomal recessive transfer disease characterised by retinal dystrophy, obesity, extremity deformities, mental retardation, and renal and genital system anomalies. BBS shows heterogenic transfer. To date, 18 genes (BBS1–18) and 7 BBS proteins have been defined as related to BBS. All of the defined BBS genes have been shown to be related to the biogenesis or function of cilia. Renal failure accompanying the syndrome, especially in the advanced stages, is the most common cause of mortality. Therefore, as one of the major diagnostic criteria, renal damage is of great importance in early diagnosis. This paper presents the cases of two brothers with BBS who presented with chronic renal failure. PMID:25960897

  8. Health assessment for Mathis Brothers Landfill, Kensington, Georgia, Region 4. CERCLIS No. GAD980838619. Preliminary report

    SciTech Connect

    Not Available

    1988-09-29

    The Mathis Brothers Landfill (MBL) is on the National Priorities List. MBL is a 20-acre site and is located on the east side of Marble Top Road, one-half mile south of State Highway 136 near Kensington (Walker), Georgia. MBL was licensed by the State to accept nonhazardous waste. The landfill is uncapped and rusted, leaking drums presently exist on-site. No removal operations have occurred. On-site contaminants of concern include lead, various residues from herbicide manufacturing and latex waste from carpet manufacturing. Based on the available information, the site is considered to be of potential public health concern because of the risk to human health caused by the possibility of exposure to hazardous substances.

  9. Health hazard evaluation report HETA 85-002-1551, Salomon Brothers, New York, New York

    SciTech Connect

    Fannick, N.

    1985-01-01

    Carbon-monoxide (630080) and carbon-dioxide (124389) concentrations were measured at Salomon Brothers, Incorporated (SIC-6711), New York, New York, in September and October, 1984. The evaluation was requested by the firm's medical department because of complaints of headache and eye, nose, and sinus irritation among employees who worked on the 40th floor, trading center. Ventilation surveys were also performed. After additional ventilation equipment was installed, a second survey found that the outdoor air supplied exceeded the ASHRAE recommendations. Following installation of the supplemental ventilation equipment, the employees complaints abated. The author concludes that in the preliminary survey, a potential health hazard existed due to an inadequate supply of fresh air. Installation of additional ventilation equipment removed the potential hazard.

  10. MECP2 triplication in 3 brothers - a rarely described cause of familial neurological regression in boys.

    PubMed

    Tang, Shan S; Fernandez, Daphin; Lazarou, Lazarus P; Singh, Rahul; Fallon, Penny

    2012-03-01

    Male patients with large duplications of the methyl CpG-binding protein 2 (MECP2) gene have been identified with a characteristic phenotype consisting of infantile hypotonia replaced by spasticity, developmental delay, severe mental retardation and recurrent respiratory infections. Only one patient with MECP2 triplication, with a more severe phenotype has been reported so far. We report three brothers of unrelated parents with MECP2 triplication. Their phenotypic features include macrocephaly with large ears, infantile hypotonia, developmental delay, significant constipation, recurrent severe respiratory tract infections from early childhood, and seizures followed by neurological regression in late childhood. Our cases indicate that MECP2 triplication is similar to or more severe than that of MECP2 duplication syndrome. PMID:21821449

  11. The Rise of Big Data in Neurorehabilitation.

    PubMed

    Faroqi-Shah, Yasmeen

    2016-02-01

    In some fields, Big Data has been instrumental in analyzing, predicting, and influencing human behavior. However, Big Data approaches have so far been less central in speech-language pathology. This article introduces the concept of Big Data and provides examples of Big Data initiatives pertaining to adult neurorehabilitation. It also discusses the potential theoretical and clinical contributions that Big Data can make. The article also recognizes some impediments in building and using Big Data for scientific and clinical inquiry. PMID:26882360

  12. Transmission of the FRAXA haplotype from three nonpenetrant brothers to their affected grandsons: an update with AGG interspersion analysis.

    PubMed

    Mogk, R L; Carson, N L; Chudley, A E; Dawson, A J

    1998-01-01

    Recently, we reported on a family showing transmission of the FRAXA gene by three nonpenetrant, normally intelligent, full and half brothers to their affected grandsons [Kirkilionis et al., 1992]. We have reanalyzed this family for CGG repeat size by polymerase chain reaction (PCR) amplification/Southern blot and FMR1 methylation status using EcoRI/BssHII double digests with pE5-1 as the hybridization probe. The half brother was found to have a premutation allele size of 59 CGG repeats. MnlI digestion of PCR products showed the absence of intervening AGG sequences. All of his obligate carrier daughters had CGG alleles ranging from 65 to 90 repeats, with a final expansion of more than 200 repeats in his FRAXA-affected grandson and 131 repeats in his carrier granddaughter. Two full brothers were shown to have inherited a 47-CGG repeat premutation allele. Analysis of one brother showed that he stably transmitted the 47-repeat allele to his daughter. Analysis of the second brother, his daughter, and his granddaughter showed that this allele was meiotically unstable, with the allele size increasing from 47, to 48, to 49 from the father, to the daughter to the granddaughter, respectively. MnlI digestion and DNA sequencing of PCR products showed the absence of intervening AGG sequences. This is the first case in which the lack of AGG interspersions has been associated with instability of a gray zone allele resulting in a one-repeat increase in two successive generations. PMID:9450853

  13. Observations of Local Seismicity and Harmonic Tremor Using an Ocean Bottom Hydrophone Array at Brothers Volcano, South Kermadec Arc.

    NASA Astrophysics Data System (ADS)

    Haxel, J. H.; Dziak, R. P.; Lau, T. K.; Matsumoto, H.

    2005-12-01

    The submarine Brothers volcano is an important link in the volcanic chain of the southern Kermadec Arc system in the Southwest Pacific Ocean north of New Zealand. The 3-3.5 km wide caldera has a center depth of 1850m and steep surrounding walls of 300-450m. Active hydrothermal venting distinguished Brothers as a point of focus for the New Zealand American Submarine Ring of Fire (NZASRoF) expeditions in 2004 and 2005. Due to its remote location, moderate to small magnitude seismicity around the Brothers area is largely unknown. In late September 2004, four ocean bottom hydrophones (OBHs) were deployed on the caldera floor. In April 2005, three of the four instruments were recovered intact. These three OBHs continuously recorded, for seven months, the low frequency (0-110Hz) acoustic field around Brothers volcano, in particular seismic P- and S-waves propagating through the crust and acoustic T-waves in the water column . Preliminary analysis reveals seismicity rates on the order of 106 earthquakes per month. In addition to seismic arrivals, low frequency harmonic tremor is frequently and independently observed on each of the OBH instruments, often occurring subsequent to the larger seismic events. Qualitative comparisons of these signals with tremor observed from the Volcano Islands south of Japan (Dziak and Fox, 2002) show them to be nearly equivalent in frequency structure, suggesting the origin of the tremor observed at Brothers may also be attributed to resonance of a magma-gas mixture in a large chamber or conduit near the water/ seafloor boundary.

  14. Volunteers in Community Mental Health.

    ERIC Educational Resources Information Center

    National Inst. of Mental Health (DHEW), Bethesda, MD.

    This booklet gives detailed accounts of mental health programs in operation around the nation. A total of nine different types of activities is included. "Helping Children" describes a program whereby students from nearby colleges give troubled children, at home, an experience in friendship by serving as big brothers or sisters. "Helping the…

  15. Big-bounce genesis

    NASA Astrophysics Data System (ADS)

    Li, Changhong; Brandenberger, Robert H.; Cheung, Yeuk-Kwan E.

    2014-12-01

    We report on the possibility of using dark matter particle's mass and its interaction cross section as a smoking gun signal of the existence of a big bounce at the early stage in the evolution of our currently observed universe. A model independent study of dark matter production in the pre-bounce contraction and the post-bounce expansion epochs of the bounce universe reveals a new venue for achieving the observed relic abundance of our present universe, in which a significantly smaller amount of dark matter with a smaller cross section—as compared to the prediction of standard cosmology—is produced and the information about the bounce universe evolution is preserved by the out-of-thermal-equilibrium process. Once the value of dark matter mass and interaction cross section are obtained by direct detection in laboratories, this alternative route becomes a signature prediction of the bounce universe scenario.

  16. Big cat genomics.

    PubMed

    O'Brien, Stephen J; Johnson, Warren E

    2005-01-01

    Advances in population and quantitative genomics, aided by the computational algorithms that employ genetic theory and practice, are now being applied to biological questions that surround free-ranging species not traditionally suitable for genetic enquiry. Here we review how applications of molecular genetic tools have been used to describe the natural history, present status, and future disposition of wild cat species. Insight into phylogenetic hierarchy, demographic contractions, geographic population substructure, behavioral ecology, and infectious diseases have revealed strategies for survival and adaptation of these fascinating predators. Conservation, stabilization, and management of the big cats are important areas that derive benefit from the genome resources expanded and applied to highly successful species, imperiled by an expanding human population. PMID:16124868

  17. Silicic Eruptions of the Past 50 kyr at the Three Sisters Volcanic Cluster

    NASA Astrophysics Data System (ADS)

    Calvert, A. T.; Hildreth, W.; Fierstein, J.

    2003-12-01

    The Three Sisters volcanic cluster in the central Oregon Cascades consists of mafic to intermediate stratovolcanoes surrounded by mafic and silicic flows and domes. The bulk of South and Middle Sister are late Pleistocene while North Sister is middle Pleistocene (Schmidt and Grunder, 2003 GSA abs.). Thick rhyolite and dacite lava flows and domes are rich in potassium, and young glaciation exposes holocrystalline groundmass textures ideal for argon geochronology. Several of these silicic flows bracket stratovolcano growth, and precise geochronology illuminates a rich basalt to rhyolite history in the cluster over the past 50 kyr. Careful step-heating 40Ar/39Ar experiments yield excellent plateau ages with radiogenic yields often above 5% on rocks as young as 20 ka. Most samples have well-determined isochrons with atmospheric (40/36 = 295.5) intercepts, although several have intercepts as low as 286. South Sister is a composite cone with an andesite/dacite base (Hodge Crest) and a young andesite summit sequence. The basal flow of the 300m-thick, youngest conformable stack of andesite lavas at the summit is 27+/-3 ka. Unconformably underlying portions date back to at least 50 ka based on ages of overlapping silicic flows. The base of Middle Sister is andesite overlain by ˜300m of olivine basalt. Some Middle Sister andesites and all basalts overlie a distinctive dacite agglutinate (20+/-2 ka) in the South/Middle Sister saddle. All Middle Sister lavas underlie a thick dacite flow (14+/-3 ka) that vented at 8500 ft (2600m) on its S flank. Dacite lava flows erupted from the Middle/North Sister saddle at 27+/-2 and 18+/-2 ka. Additionally, several >100m-thick rhyolite and dacite lavas vented low on the flanks of the cluster. Obsidian Cliff rhyolite (37.8+/-1.8 ka) and Lane Plateau dacite (21.4+/-1.9 ka) erupted W of Middle Sister, the Dew Lake dacite (32.3+/-1.8 ka) located near the locus of the INSAR anomaly W of South Sister flowed around a 148+/-4 ka (knob 6482) basalt

  18. Big bang and big crunch in matrix string theory

    SciTech Connect

    Bedford, J.; Ward, J.; Papageorgakis, C.; Rodriguez-Gomez, D.

    2007-04-15

    Following the holographic description of linear dilaton null cosmologies with a big bang in terms of matrix string theory put forward by Craps, Sethi, and Verlinde, we propose an extended background describing a universe including both big bang and big crunch singularities. This belongs to a class of exact string backgrounds and is perturbative in the string coupling far away from the singularities, both of which can be resolved using matrix string theory. We provide a simple theory capable of describing the complete evolution of this closed universe.

  19. Big bang and big crunch in matrix string theory

    NASA Astrophysics Data System (ADS)

    Bedford, J.; Papageorgakis, C.; Rodríguez-Gómez, D.; Ward, J.

    2007-04-01

    Following the holographic description of linear dilaton null cosmologies with a big bang in terms of matrix string theory put forward by Craps, Sethi, and Verlinde, we propose an extended background describing a universe including both big bang and big crunch singularities. This belongs to a class of exact string backgrounds and is perturbative in the string coupling far away from the singularities, both of which can be resolved using matrix string theory. We provide a simple theory capable of describing the complete evolution of this closed universe.

  20. Shugoshin1 May Play Important Roles in Separation of Homologous Chromosomes and Sister Chromatids during Mouse Oocyte Meiosis

    PubMed Central

    Yin, Shen; Ai, Jun-Shu; Shi, Li-Hong; Wei, Liang; Yuan, Ju; Ouyang, Ying-Chun; Hou, Yi; Chen, Da-Yuan; Schatten, Heide; Sun, Qing-Yuan

    2008-01-01

    Background Homologous chromosomes separate in meiosis I and sister chromatids separate in meiosis II, generating haploid gametes. To address the question why sister chromatids do not separate in meiosis I, we explored the roles of Shogoshin1 (Sgo1) in chromosome separation during oocyte meiosis. Methodology/Principal Findings Sgo1 function was evaluated by exogenous overexpression to enhance its roles and RNAi to suppress its roles during two meioses of mouse oocytes. Immunocytochemistry and chromosome spread were used to evaluate phenotypes. The exogenous Sgo1 overexpression kept homologous chromosomes and sister chromatids not to separate in meiosis I and meiosis II, respectively, while the Sgo1 RNAi promoted premature separation of sister chromatids. Conclusions Our results reveal that prevention of premature separation of sister chromatids in meiosis I requires the retention of centromeric Sgo1, while normal separation of sister chromatids in meiosis II requires loss of centromeric Sgo1. PMID:18949044

  1. Digital Data for Volcano Hazards of the Three Sisters Region, Oregon

    USGS Publications Warehouse

    Schilling, S.P.; Doelger, S.; Scott, W.E.; Iverson, R.M.

    2008-01-01

    Three Sisters is one of three active volcanic centers that lie close to rapidly growing communities and resort areas in Central Oregon. The major composite volcanoes of this area are clustered near the center of the region and include South Sister, Middle Sister, and Broken Top. Additionally, hundreds of mafic volcanoes are scattered throughout the Three Sisters area. These range from small cinder cones to large shield volcanoes like North Sister and Belknap Crater. Hazardous events include landslides from the steep flanks of large volcanoes and floods, which need not be triggered by eruptions, as well as eruption-triggered events such as fallout of tephra (volcanic ash) and lava flows. A proximal hazard zone roughly 20 kilometers (12 miles) in diameter surrounding the Three Sisters and Broken Top could be affected within minutes of the onset of an eruption or large landslide. Distal hazard zones that follow river valleys downstream from the Three Sisters and Broken Top could be inundated by lahars (rapid flows of water-laden rock and mud) generated either by melting of snow and ice during eruptions or by large landslides. Slow-moving lava flows could issue from new mafic volcanoes almost anywhere within the region. Fallout of tephra from eruption clouds can affect areas hundreds of kilometers (miles) downwind, so eruptions at volcanoes elsewhere in the Cascade Range also contribute to volcano hazards in Central Oregon. Scientists at the Cascades Volcano Observatory created a geographic information system (GIS) data set which depicts proximal and distal lahar hazard zones as well as a regional lava flow hazard zone for Three Sisters (USGS Open-File Report 99-437, Scott and others, 1999). The various distal lahar zones were constructed from LaharZ software using 20, 100, and 500 million cubic meter input flow volumes. Additionally, scientists used the depositional history of past events in the Three Sisters Region as well as experience and judgment derived from the

  2. Homogeneous and isotropic big rips?

    SciTech Connect

    Giovannini, Massimo

    2005-10-15

    We investigate the way big rips are approached in a fully inhomogeneous description of the space-time geometry. If the pressure and energy densities are connected by a (supernegative) barotropic index, the spatial gradients and the anisotropic expansion decay as the big rip is approached. This behavior is contrasted with the usual big-bang singularities. A similar analysis is performed in the case of sudden (quiescent) singularities and it is argued that the spatial gradients may well be non-negligible in the vicinity of pressure singularities.

  3. The challenges of big data

    PubMed Central

    2016-01-01

    ABSTRACT The largely untapped potential of big data analytics is a feeding frenzy that has been fueled by the production of many next-generation-sequencing-based data sets that are seeking to answer long-held questions about the biology of human diseases. Although these approaches are likely to be a powerful means of revealing new biological insights, there are a number of substantial challenges that currently hamper efforts to harness the power of big data. This Editorial outlines several such challenges as a means of illustrating that the path to big data revelations is paved with perils that the scientific community must overcome to pursue this important quest. PMID:27147249

  4. Big Data and Ambulatory Care

    PubMed Central

    Thorpe, Jane Hyatt; Gray, Elizabeth Alexandra

    2015-01-01

    Big data is heralded as having the potential to revolutionize health care by making large amounts of data available to support care delivery, population health, and patient engagement. Critics argue that big data's transformative potential is inhibited by privacy requirements that restrict health information exchange. However, there are a variety of permissible activities involving use and disclosure of patient information that support care delivery and management. This article presents an overview of the legal framework governing health information, dispels misconceptions about privacy regulations, and highlights how ambulatory care providers in particular can maximize the utility of big data to improve care. PMID:25401945

  5. The challenges of big data.

    PubMed

    Mardis, Elaine R

    2016-05-01

    The largely untapped potential of big data analytics is a feeding frenzy that has been fueled by the production of many next-generation-sequencing-based data sets that are seeking to answer long-held questions about the biology of human diseases. Although these approaches are likely to be a powerful means of revealing new biological insights, there are a number of substantial challenges that currently hamper efforts to harness the power of big data. This Editorial outlines several such challenges as a means of illustrating that the path to big data revelations is paved with perils that the scientific community must overcome to pursue this important quest. PMID:27147249

  6. Rate Change Big Bang Theory

    NASA Astrophysics Data System (ADS)

    Strickland, Ken

    2013-04-01

    The Rate Change Big Bang Theory redefines the birth of the universe with a dramatic shift in energy direction and a new vision of the first moments. With rate change graph technology (RCGT) we can look back 13.7 billion years and experience every step of the big bang through geometrical intersection technology. The analysis of the Big Bang includes a visualization of the first objects, their properties, the astounding event that created space and time as well as a solution to the mystery of anti-matter.

  7. Sisters unbound is required for meiotic centromeric cohesion in Drosophila melanogaster.

    PubMed

    Krishnan, Badri; Thomas, Sharon E; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B; McKee, Bruce D

    2014-11-01

    Regular meiotic chromosome segregation requires sister centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when sister chromatids segregate. Both orientation patterns require cohesion between sister centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called sisters unbound (sunn), which is required for stable sister chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162

  8. Genomic data do not support comb jellies as the sister group to all other animals

    PubMed Central

    Pisani, Davide; Pett, Walker; Dohrmann, Martin; Feuda, Roberto; Rota-Stabelli, Omar; Philippe, Hervé; Lartillot, Nicolas; Wörheide, Gert

    2015-01-01

    Understanding how complex traits, such as epithelia, nervous systems, muscles, or guts, originated depends on a well-supported hypothesis about the phylogenetic relationships among major animal lineages. Traditionally, sponges (Porifera) have been interpreted as the sister group to the remaining animals, a hypothesis consistent with the conventional view that the last common animal ancestor was relatively simple and more complex body plans arose later in evolution. However, this premise has recently been challenged by analyses of the genomes of comb jellies (Ctenophora), which, instead, found ctenophores as the sister group to the remaining animals (the “Ctenophora-sister” hypothesis). Because ctenophores are morphologically complex predators with true epithelia, nervous systems, muscles, and guts, this scenario implies these traits were either present in the last common ancestor of all animals and were lost secondarily in sponges and placozoans (Trichoplax) or, alternatively, evolved convergently in comb jellies. Here, we analyze representative datasets from recent studies supporting Ctenophora-sister, including genome-scale alignments of concatenated protein sequences, as well as a genomic gene content dataset. We found no support for Ctenophora-sister and conclude it is an artifact resulting from inadequate methodology, especially the use of simplistic evolutionary models and inappropriate choice of species to root the metazoan tree. Our results reinforce a traditional scenario for the evolution of complexity in animals, and indicate that inferences about the evolution of Metazoa based on the Ctenophora-sister hypothesis are not supported by the currently available data. PMID:26621703

  9. High density of REC8 constrains sister chromatid axes and prevents illegitimate synaptonemal complex formation.

    PubMed

    Agostinho, Ana; Manneberg, Otto; van Schendel, Robin; Hernández-Hernández, Abrahan; Kouznetsova, Anna; Blom, Hans; Brismar, Hjalmar; Höög, Christer

    2016-06-01

    During meiosis, cohesin complexes mediate sister chromatid cohesion (SCC), synaptonemal complex (SC) assembly and synapsis. Here, using super-resolution microscopy, we imaged sister chromatid axes in mouse meiocytes that have normal or reduced levels of cohesin complexes, assessing the relationship between localization of cohesin complexes, SCC and SC formation. We show that REC8 foci are separated from each other by a distance smaller than 15% of the total chromosome axis length in wild-type meiocytes. Reduced levels of cohesin complexes result in a local separation of sister chromatid axial elements (LSAEs), as well as illegitimate SC formation at these sites. REC8 but not RAD21 or RAD21L cohesin complexes flank sites of LSAEs, whereas RAD21 and RAD21L appear predominantly along the separated sister-chromatid axes. Based on these observations and a quantitative distribution analysis of REC8 along sister chromatid axes, we propose that the high density of randomly distributed REC8 cohesin complexes promotes SCC and prevents illegitimate SC formation. PMID:27170622

  10. Sister cohesion and structural axis components mediate homolog bias of meiotic recombination

    PubMed Central

    Kim, Keun P.; Weiner, Beth M.; Zhang, Liangran; Jordan, Amy; Dekker, Job; Kleckner, Nancy

    2010-01-01

    SUMMARY Meiotic recombination occurs between one chromatid of each maternal and paternal homolog (homolog bias) versus between sister chromatids (sister bias). Physical DNA analysis reveals that meiotic cohesin/axis component Rec8 promotes sister bias, likely via its cohesion activity. Two meiosis-specific axis components, Red1/Mek1kinase, counteract this effect. With this precondition satisfied, other molecules directly specify homolog bias per se. Rec8 also acts positively to maintain homolog bias during crossover recombination. These observations point to sequential release of double-strand break ends from association with their sister. Red1 and Rec8 are found to play distinct roles for sister cohesion, DSB formation and recombination progression kinetics. Also, the two components are enriched in spatially distinct domains of axial structure that develop prior to DSB formation. We propose that Red1 and Rec8 domains provide functionally complementary environments whereby inputs evolved from DSB repair and late-stage chromosome morphogenesis are integrated to give the complete meiotic chromosomal program. PMID:21145459

  11. Sisters Unbound Is Required for Meiotic Centromeric Cohesion in Drosophila melanogaster

    PubMed Central

    Krishnan, Badri; Thomas, Sharon E.; Yan, Rihui; Yamada, Hirotsugu; Zhulin, Igor B.; McKee, Bruce D.

    2014-01-01

    Regular meiotic chromosome segregation requires sister centromeres to mono-orient (orient to the same pole) during the first meiotic division (meiosis I) when homologous chromosomes segregate, and to bi-orient (orient to opposite poles) during the second meiotic division (meiosis II) when sister chromatids segregate. Both orientation patterns require cohesion between sister centromeres, which is established during meiotic DNA replication and persists until anaphase of meiosis II. Meiotic cohesion is mediated by a conserved four-protein complex called cohesin that includes two structural maintenance of chromosomes (SMC) subunits (SMC1 and SMC3) and two non-SMC subunits. In Drosophila melanogaster, however, the meiotic cohesion apparatus has not been fully characterized and the non-SMC subunits have not been identified. We have identified a novel Drosophila gene called sisters unbound (sunn), which is required for stable sister chromatid cohesion throughout meiosis. sunn mutations disrupt centromere cohesion during prophase I and cause high frequencies of non-disjunction (NDJ) at both meiotic divisions in both sexes. SUNN co-localizes at centromeres with the cohesion proteins SMC1 and SOLO in both sexes and is necessary for the recruitment of both proteins to centromeres. Although SUNN lacks sequence homology to cohesins, bioinformatic analysis indicates that SUNN may be a structural homolog of the non-SMC cohesin subunit stromalin (SA), suggesting that SUNN may serve as a meiosis-specific cohesin subunit. In conclusion, our data show that SUNN is an essential meiosis-specific Drosophila cohesion protein. PMID:25194162

  12. The management of professionals: the preferences of hospital sisters and charge nurses.

    PubMed

    Foster, D

    1995-05-01

    This analysis of the preferences of how sisters and charge nurses are managed is the result of a two centre descriptive study using theoretical models of professionalism, developing preferences and exercising situational leadership. It was conducted to determine if the management structure preferred by sisters and charge nurses, in a general acute hospital setting, supported the professionalism of nursing. The outcomes were intended to help develop a strategic plan for the future of nursing and the management of nurses. The research instruments were a self-completed questionnaire (19 were returned, a response rate of 31.1%) and four semi-structured interviews. The findings disclosed some dissatisfaction with the present management arrangements. The sisters and charge nurses felt that their priorities for practice and professional issues were better supported by clinically involved, ward-based senior nurses than by unit-based senior nurses with a general management function. However, sisters' and charge nurses' discussions with ward-based senior nurses were apparently less effective than discussions in peer groups which led to influential collegial autonomy. This preferred management style can be supported by the use of situational leadership theory which would enhance collegial autonomy and professional satisfaction. Recognition of the sisters and charge nurses preferences and adjustment of their management would therefore enable them to participate effectively in organizational decision-making. PMID:7773517

  13. Links between sisters' sexual and dating victimization: the roles of neighborhood crime and parental controls.

    PubMed

    East, Patricia L; Chien, Nina C; Adams, Joyce A; Hokoda, Audrey; Maier, Ashley

    2010-12-01

    This study examined the extent to which a sister's prior sexual and dating victimization is a risk factor for young women being similarly victimized and the possible factors underlying a co-occurrence. The sample involved 122 young adult Latina or African American sister pairs (244 women; ages 16-25) who resided in low-income, urban neighborhoods. Results indicated that women whose sisters had been victimized had increased risk of victimization even after controlling for neighborhood crime, parental controls, age and race-ethnicity (odds ratios were 4.0 for unwanted touching, 6.2 for a forced sex act, and 16.7 for dating violence). In high-crime neighborhoods, the presence of two adult parent figures in the home was associated with women's reduced likelihood of unwanted touching, and mothers' high monitoring during adolescence was associated with women's lower risk of dating aggression. Survival analysis results showed that the risk period of a second sister being victimized lasts between 7 and 10 years after a first sister's victimization. The prevention implications of study findings are discussed. PMID:21171768

  14. Mechanics of Sister Chromatids studied with a Polymer Model English</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Zhang, Yang; Isbaner, Sebastian; Heermann, Dieter</p> <p>2013-10-01</p> <p><span class="hlt">Sister</span> chromatid cohesion denotes the phenomenon that <span class="hlt">sister</span> chromatids are initially attached to each other in mitosis to guarantee the error-free distribution into the daughter cells. Cohesion is mediated by binding proteins and only resolved after mitotic chromosome condensation is completed. However, the amount of attachement points required to maintain <span class="hlt">sister</span> chromatid cohesion while still allowing proper chromosome condensation is not known yet. Additionally the impact of cohesion on the mechanical properties of chromosomes also poses an interesting problem. In this work we study the conformational and mechanical properties of <span class="hlt">sister</span> chromatids by means of computer simulations. We model both protein-mediated cohesion between <span class="hlt">sister</span> chromatids and chromosome condensation with a dynamic binding mechanisms. We show in a phase diagram that only specific link concentrations lead to connected and fully condensed chromatids that do not intermingle with each other nor separate due to entropic forces. Furthermore we show that dynamic bonding between chromatids decrease the Young's modulus compared to non-bonded chromatids.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2015EGUGA..17.6841M&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2015EGUGA..17.6841M&link_type=ABSTRACT"><span id="translatedtitle"><span class="hlt">Big</span> climate data analysis</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mudelsee, Manfred</p> <p>2015-04-01</p> <p>The <span class="hlt">Big</span> Data era has begun also in the climate sciences, not only in economics or molecular biology. We measure climate at increasing spatial resolution by means of satellites and look farther back in time at increasing temporal resolution by means of natural archives and proxy data. We use powerful supercomputers to run climate models. The model output of the calculations made for the IPCC's Fifth Assessment Report amounts to ~650 TB. The 'scientific evolution' of grid computing has started, and the 'scientific revolution' of quantum computing is being prepared. This will increase computing power, and data amount, by several orders of magnitude in the future. However, more data does not automatically mean more knowledge. We need statisticians, who are at the core of transforming data into knowledge. Statisticians notably also explore the limits of our knowledge (uncertainties, that is, confidence intervals and P-values). Mudelsee (2014 Climate Time Series Analysis: Classical Statistical and Bootstrap Methods. Second edition. Springer, Cham, xxxii + 454 pp.) coined the term 'optimal estimation'. Consider the hyperspace of climate estimation. It has many, but not infinite, dimensions. It consists of the three subspaces Monte Carlo design, method and measure. The Monte Carlo design describes the data generating process. The method subspace describes the estimation and confidence interval construction. The measure subspace describes how to detect the optimal estimation method for the Monte Carlo experiment. The envisaged large increase in computing power may bring the following idea of optimal climate estimation into existence. Given a data sample, some prior information (e.g. measurement standard errors) and a set of questions (parameters to be estimated), the first task is simple: perform an initial estimation on basis of existing knowledge and experience with such types of estimation problems. The second task requires the computing power: explore the hyperspace to</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhLB..751..464K','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhLB..751..464K"><span id="translatedtitle"><span class="hlt">Big</span> bang darkleosynthesis</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Krnjaic, Gordan; Sigurdson, Kris</p> <p>2015-12-01</p> <p>In a popular class of models, dark matter comprises an asymmetric population of composite particles with short range interactions arising from a confined nonabelian gauge group. We show that coupling this sector to a well-motivated light mediator particle yields efficient darkleosynthesis, a dark-sector version of <span class="hlt">big</span>-bang nucleosynthesis (BBN), in generic regions of parameter space. Dark matter self-interaction bounds typically require the confinement scale to be above ΛQCD, which generically yields large (≫MeV /dark-nucleon) binding energies. These bounds further suggest the mediator is relatively weakly coupled, so repulsive forces between dark-sector nuclei are much weaker than Coulomb repulsion between standard-model nuclei, which results in an exponential barrier-tunneling enhancement over standard BBN. Thus, darklei are easier to make and harder to break than visible species with comparable mass numbers. This process can efficiently yield a dominant population of states with masses significantly greater than the confinement scale and, in contrast to dark matter that is a fundamental particle, may allow the dominant form of dark matter to have high spin (S ≫ 3 / 2), whose discovery would be smoking gun evidence for dark nuclei.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://ntrs.nasa.gov/search.jsp?R=PIA09077&hterms=Blueberries&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DBlueberries','NASA-TRS'); return false;" href="http://ntrs.nasa.gov/search.jsp?R=PIA09077&hterms=Blueberries&qs=Ntx%3Dmode%2Bmatchall%26Ntk%3DAll%26N%3D0%26No%3D10%26Ntt%3DBlueberries"><span id="translatedtitle"><span class="hlt">Big</span> Spherules near 'Victoria'</span></a></p> <p><a target="_blank" href="http://ntrs.nasa.gov/search.jsp">NASA Technical Reports Server (NTRS)</a></p> <p></p> <p>2006-01-01</p> <p><p/> This frame from the microscopic imager on NASA's Mars Exploration Rover Opportunity shows spherules up to about 5 millimeters (one-fifth of an inch) in diameter. The camera took this image during the 924th Martian day, or sol, of Opportunity's Mars-surface mission (Aug. 30, 2006), when the rover was about 200 meters (650 feet) north of 'Victoria Crater.' <p/> Opportunity discovered spherules like these, nicknamed 'blueberries,' at its landing site in 'Eagle Crater,' and investigations determined them to be iron-rich concretions that formed inside deposits soaked with groundwater. However, such concretions were much smaller or absent at the ground surface along much of the rover's trek of more than 5 kilometers (3 miles) southward to Victoria. The <span class="hlt">big</span> ones showed up again when Opportunity got to the ring, or annulus, of material excavated and thrown outward by the impact that created Victoria Crater. Researchers hypothesize that some layer beneath the surface in Victoria's vicinity was once soaked with water long enough to form the concretions, that the crater-forming impact dispersed some material from that layer, and that Opportunity might encounter that layer in place if the rover drives down into the crater.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1027233','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1027233"><span id="translatedtitle">The <span class="hlt">Big</span>BOSS Experiment</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna</p> <p>2011-01-01</p> <p><span class="hlt">Big</span>BOSS will obtain observational constraints that will bear on three of the four 'science frontier' questions identified by the Astro2010 Cosmology and Fundamental Phyics Panel of the Decadal Survey: Why is the universe accelerating; what is dark matter and what are the properties of neutrinos? Indeed, the <span class="hlt">Big</span>BOSS project was recommended for substantial immediate R and D support the PASAG report. The second highest ground-based priority from the Astro2010 Decadal Survey was the creation of a funding line within the NSF to support a 'Mid-Scale Innovations' program, and it used <span class="hlt">Big</span>BOSS as a 'compelling' example for support. This choice was the result of the Decadal Survey's Program Priorization panels reviewing 29 mid-scale projects and recommending <span class="hlt">Big</span>BOSS 'very highly'.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23076835','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23076835"><span id="translatedtitle">Using a sibling design to compare childhood adversities in female patients with BPD and their <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Laporte, Lise; Paris, Joel; Guttman, Herta; Russell, Jennifer; Correa, José A</p> <p>2012-11-01</p> <p>Abuse and neglect are well-established risk correlates of borderline personality disorder (BPD). The goal of this study was to examine whether BPD probands can be differentiated from their <span class="hlt">sisters</span> with respect to a range of developmental adversity and maltreatment indicators, including retrospective self-reports of past experiences of childhood abuse and neglect, dysfunctional parent-child relationships and peer victimization and dysfunctional peer relationships. A total of 53 patients with BPD were compared to 53 <span class="hlt">sisters</span> who were currently free of psychopathology on measures assessing childhood adversities. Both probands and <span class="hlt">sisters</span> reported similar prevalence of intrafamilial abuse, although BPD patients reported more severe physical and emotional abuse. BPD patients reported higher prevalence of physical abuse by peers. These findings generally support the principle of multifinality, in which similar histories of adversities can be associated with a variety of outcomes, ranging from psychopathology to resilience. PMID:23076835</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005NW.....92..586B&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2005NW.....92..586B&link_type=ABSTRACT"><span id="translatedtitle">Osteological evidence for <span class="hlt">sister</span> group relationship between pseudo-toothed birds (Aves: Odontopterygiformes) and waterfowls (Anseriformes)</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bourdon, Estelle</p> <p>2005-12-01</p> <p>The phylogenetic affinities of the extinct pseudo-toothed birds have remained controversial. Some authors noted that they resemble both pelicans and allies (Pelecaniformes) and tube-nosed birds (Procellariiformes), but assigned them to a distinct taxon, the Odontopterygiformes. In most recent studies, the pseudo-toothed birds are referred to the family Pelagornithidae inside the Pelecaniformes. Here, I perform a cladistic analysis with five taxa of the pseudo-toothed birds including two undescribed new species from the Early Tertiary of Morocco. The present hypothesis strongly supports a <span class="hlt">sister</span> group relationship of pseudo-toothed birds (Odontopterygiformes) and waterfowls (Anseriformes). The Odontoanserae (Odontopterygiformes plus Anseriformes) are the <span class="hlt">sister</span> group of Neoaves. The placement of the landfowls (Galliformes) as the <span class="hlt">sister</span> taxon of all other neognathous birds does not support the consensus view that the Galloanserae (Galliformes plus Anseriformes) are monophyletic.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_17");'>17</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li class="active"><span>19</span></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_19 --> <div id="page_20" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="381"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24864473','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24864473"><span id="translatedtitle">[Wilson-Konovalov disease in 3 <span class="hlt">sisters</span>: a radical change in prognosis if timely diagnosed].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Rozina, T P; Ignatova, T M; Solov'eva, O V</p> <p>2014-01-01</p> <p>Wilson-Konovalov disease is a rare autosomal recessive genetic disorder in which copper accumulates in the liver, brain and other target organs. The paper describes a family case of the abdominal form of the disease in three <span class="hlt">sisters</span>, the eldest of them died from fulminant liver failure at the age of 18 years. The second <span class="hlt">sister</span> aged 16 years was diagnosed as having the disease at the stage of decompensated liver cirrhosis; her treatment with D-penicillamine resulted in complete disease remission. The youngest <span class="hlt">sister</span> was diagnosed with the disease at the preclinical stage, which could expect its good prognosis. However, the patient's refusal of treatment led to death from liver failure. This case demonstrates the importance of timely diagnosis and the possibility of dramatic improvement in prognosis even at the stage of decompensated liver cirrhosis. PMID:24864473</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23617099','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23617099"><span id="translatedtitle">Meaning of the death of an elderly father: two <span class="hlt">sisters</span>' perspectives.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Moss, Miriam S; Moss, Sidney Z</p> <p></p> <p>Multiple bereaved adult children, as siblings, have rarely been studied. We expand the paradigm of bereavement research to explore the ways that two <span class="hlt">sisters</span> describe the experience and meaning of the death of their elderly father. The two <span class="hlt">sisters</span> each participated in two separate qualitative ethnographic interviews, followed by standard qualitative analyses of the transcribed narratives. The findings yield contrasting perspectives of the <span class="hlt">sisters</span>' disparate views of their family, of their father, and their views of each other, that provide insight into the complexity of the sharp differences in their reactions to their father's death. Their views of their father's death reflected their particular relationship with their father, their non-shared experiences over the life course, and their personal world views. Differences and contradictions in the views of multiple siblings can broaden our understanding of bereavement and of the processes central to parent-child ties at the end of life. PMID:23617099</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/21479528','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/21479528"><span id="translatedtitle">Bartter syndrome in two <span class="hlt">sisters</span> with a novel mutation of the CLCNKB gene, one with deafness.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Robitaille, Pierre; Merouani, Aicha; He, Ning; Pei, York</p> <p>2011-09-01</p> <p>This article describes two <span class="hlt">sisters</span> with type III Bartter syndrome (BS) due to a novel missense variant of the CLCNKB gene. The phenotypic expression of the disease was very different in these two siblings. In one <span class="hlt">sister</span>, the disease followed a very severe course, especially in the neonatal period and as a toddler. Both the classic symptoms and the biochemical features of the syndrome were striking. In addition, she presented with sensorineural deafness, a complication yet unreported in this subtype of BS In contrast, the least affected <span class="hlt">sister</span> was symptom free and the biochemical features of the disease although present remained discrete throughout the prolonged follow-up. It is suggested that such a difference in the phenotypic expression of the disease is possibly secondary to the modifier effect of a gene and/or results from environmental factor(s). PMID:21479528</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25419469','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25419469"><span id="translatedtitle">Challenges of <span class="hlt">Big</span> Data Analysis.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Fan, Jianqing; Han, Fang; Liu, Han</p> <p>2014-06-01</p> <p><span class="hlt">Big</span> Data bring new opportunities to modern society and challenges to data scientists. On one hand, <span class="hlt">Big</span> Data hold great promises for discovering subtle population patterns and heterogeneities that are not possible with small-scale data. On the other hand, the massive sample size and high dimensionality of <span class="hlt">Big</span> Data introduce unique computational and statistical challenges, including scalability and storage bottleneck, noise accumulation, spurious correlation, incidental endogeneity, and measurement errors. These challenges are distinguished and require new computational and statistical paradigm. This article gives overviews on the salient features of <span class="hlt">Big</span> Data and how these features impact on paradigm change on statistical and computational methods as well as computing architectures. We also provide various new perspectives on the <span class="hlt">Big</span> Data analysis and computation. In particular, we emphasize on the viability of the sparsest solution in high-confidence set and point out that exogeneous assumptions in most statistical methods for <span class="hlt">Big</span> Data can not be validated due to incidental endogeneity. They can lead to wrong statistical inferences and consequently wrong scientific conclusions. PMID:25419469</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4236847','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4236847"><span id="translatedtitle">Challenges of <span class="hlt">Big</span> Data Analysis</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fan, Jianqing; Han, Fang; Liu, Han</p> <p>2014-01-01</p> <p><span class="hlt">Big</span> Data bring new opportunities to modern society and challenges to data scientists. On one hand, <span class="hlt">Big</span> Data hold great promises for discovering subtle population patterns and heterogeneities that are not possible with small-scale data. On the other hand, the massive sample size and high dimensionality of <span class="hlt">Big</span> Data introduce unique computational and statistical challenges, including scalability and storage bottleneck, noise accumulation, spurious correlation, incidental endogeneity, and measurement errors. These challenges are distinguished and require new computational and statistical paradigm. This article gives overviews on the salient features of <span class="hlt">Big</span> Data and how these features impact on paradigm change on statistical and computational methods as well as computing architectures. We also provide various new perspectives on the <span class="hlt">Big</span> Data analysis and computation. In particular, we emphasize on the viability of the sparsest solution in high-confidence set and point out that exogeneous assumptions in most statistical methods for <span class="hlt">Big</span> Data can not be validated due to incidental endogeneity. They can lead to wrong statistical inferences and consequently wrong scientific conclusions. PMID:25419469</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2279116"><span id="translatedtitle">Single mitochondrial gene barcodes reliably identify <span class="hlt">sister</span>-species in diverse clades of birds</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2008-01-01</p> <p>Background DNA barcoding of life using a standardized COI sequence was proposed as a species identification system, and as a method for detecting putative new species. Previous tests in birds showed that individuals can be correctly assigned to species in ~94% of the cases and suggested a threshold of 10× mean intraspecific difference to detect potential new species. However, these tests were criticized because they were based on a single maternally inherited gene rather than multiple nuclear genes, did not compare phylogenetically identified <span class="hlt">sister</span> species, and thus likely overestimated the efficacy of DNA barcodes in identifying species. Results To test the efficacy of DNA barcodes we compared ~650 bp of COI in 60 <span class="hlt">sister</span>-species pairs identified in multigene phylogenies from 10 orders of birds. In all pairs, individuals of each species were monophyletic in a neighbor-joining (NJ) tree, and each species possessed fixed mutational differences distinguishing them from their <span class="hlt">sister</span> species. Consequently, individuals were correctly assigned to species using a statistical coalescent framework. A coalescent test of taxonomic distinctiveness based on chance occurrence of reciprocal monophyly in two lineages was verified in known <span class="hlt">sister</span> species, and used to identify recently separated lineages that represent putative species. This approach avoids the use of a universal distance cutoff which is invalidated by variation in times to common ancestry of <span class="hlt">sister</span> species and in rates of evolution. Conclusion Closely related <span class="hlt">sister</span> species of birds can be identified reliably by barcodes of fixed diagnostic substitutions in COI sequences, verifying coalescent-based statistical tests of reciprocal monophyly for taxonomic distinctiveness. Contrary to recent criticisms, a single DNA barcode is a rapid way to discover monophyletic lineages within a metapopulation that might represent undiscovered cryptic species, as envisaged in the unified species concept. This identifies a smaller</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24362571','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24362571"><span id="translatedtitle">RecA bundles mediate homology pairing between distant <span class="hlt">sisters</span> during DNA break repair.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J</p> <p>2014-02-13</p> <p>DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant <span class="hlt">sister</span> loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one <span class="hlt">sister</span> can be repaired efficiently using distant <span class="hlt">sister</span> homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut <span class="hlt">sister</span>. After <span class="hlt">sister</span> locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in <span class="hlt">sister</span> pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions. PMID:24362571</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014Natur.506..249L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014Natur.506..249L"><span id="translatedtitle">RecA bundles mediate homology pairing between distant <span class="hlt">sisters</span> during DNA break repair</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lesterlin, Christian; Ball, Graeme; Schermelleh, Lothar; Sherratt, David J.</p> <p>2014-02-01</p> <p>DNA double-strand break (DSB) repair by homologous recombination has evolved to maintain genetic integrity in all organisms. Although many reactions that occur during homologous recombination are known, it is unclear where, when and how they occur in cells. Here, by using conventional and super-resolution microscopy, we describe the progression of DSB repair in live Escherichia coli. Specifically, we investigate whether homologous recombination can occur efficiently between distant <span class="hlt">sister</span> loci that have segregated to opposite halves of an E. coli cell. We show that a site-specific DSB in one <span class="hlt">sister</span> can be repaired efficiently using distant <span class="hlt">sister</span> homology. After RecBCD processing of the DSB, RecA is recruited to the cut locus, where it nucleates into a bundle that contains many more RecA molecules than can associate with the two single-stranded DNA regions that form at the DSB. Mature bundles extend along the long axis of the cell, in the space between the bulk nucleoid and the inner membrane. Bundle formation is followed by pairing, in which the two ends of the cut locus relocate at the periphery of the nucleoid and together move rapidly towards the homology of the uncut <span class="hlt">sister</span>. After <span class="hlt">sister</span> locus pairing, RecA bundles disassemble and proteins that act late in homologous recombination are recruited to give viable recombinants 1-2-generation-time equivalents after formation of the initial DSB. Mutated RecA proteins that do not form bundles are defective in <span class="hlt">sister</span> pairing and in DSB-induced repair. This work reveals an unanticipated role of RecA bundles in channelling the movement of the DNA DSB ends, thereby facilitating the long-range homology search that occurs before the strand invasion and transfer reactions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/7628083','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/7628083"><span id="translatedtitle">Increased urinary excretion of analogs of Krebs cycle metabolites and arabinose in two <span class="hlt">brothers</span> with autistic features.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Shaw, W; Kassen, E; Chaves, E</p> <p>1995-08-01</p> <p>A marked increase in analogs of Krebs cycle metabolites was found in the urine of two <span class="hlt">brothers</span> with autistic features. These metabolites included citramalic, tartaric (3-OH-malic), and 3-oxoglutaric acids and compounds tentatively identified as a citric acid analog and partially identified as a phenylcarboxylic acid by the fragmentation pattern of the trimethylsilyl (TMS) derivatives of the compounds and mass shifts of the same compounds derivatized with perdeuterated N,O-bis(trimethylsilyl)trifluoroacetamide. The molecular mass of the TMS derivative of the tentatively identified citric acid analog was 596 Da, based on a finding of a significant M - 15 ion at m/z 581. The citric acid analog was excreted in quantities as high as 137 mmol/mol creatinine, based on the response factor of citric acid as a surrogate calibrator. A carbohydrate with a retention time and mass spectrum identical to arabinose was also found in high concentrations in the urine of these <span class="hlt">brothers</span>. PMID:7628083</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6839185','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6839185"><span id="translatedtitle">Superfund Record of Decision (EPA Region 4): Mathis <span class="hlt">Brothers</span> Landfill (South Marble Top Road), Walker County, GA, March 1993</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1993-03-01</p> <p>This decision document (Record of Decision) presents the selected remedial action for the Mathis <span class="hlt">Brothers</span> - South Marble Top Road Landfill site, Walker County, Georgia. At this time the remedial action is proposed as both the first, and the final remedial action for the site. The function of this remedy is to treat contamination and reduce it to health based levels. Source material and contaminated soils are the principal threat at the site.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/6622092','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/6622092"><span id="translatedtitle">Megacystis-microcolon-intestinal hypoperistalsis syndrome in a newborn girl whose <span class="hlt">brother</span> had prune belly syndrome: common pathogenesis?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Oliveira, G; Boechat, M I; Ferreira, M A</p> <p>1983-01-01</p> <p>A case of megacystis-microcolon-intestinal hypoperistalsis syndrome (MMIHS) is presented. There were important findings: a urachal remnant and a <span class="hlt">brother</span> with prune belly syndrome (PBS). After a review of the literature, many common characteristics of MMIHS and PBS are described: flaccid abdomen, dilatation of the urinary tract, intestinal malrotation, cryptorchidism, urachal remnants and familial incidence. MMIHS and PBS may be manifestations of the same underlying process. PMID:6622092</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25069154','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25069154"><span id="translatedtitle">My <span class="hlt">brother</span>'s reaper: examining officially reported siblicide incidents in the United States, 2000-2007.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Walsh, Jeffrey A; Krienert, Jessie L</p> <p>2014-01-01</p> <p>With higher rates than any other form of intrafamilial violence, Hoffman and Edwards (2004) note, sibling violence "constitutes a pandemic form of victimization of children, with the symptoms often going unrecognized and the effect ignored" (p. 187). Approximately 80% of children reside with at least one sibling (Kreider, 2008), and in its most extreme form sibling violence manifests as siblicide. Siblicide is poorly understood with fewer than 20 empirical studies identified in the extant literature since 1980 (see Eriksen & Jensen, 2006). The present work employs 8 years of Supplemental Homicide Report (SHR) data, 2000-2007, with siblicide victims and offenders age 21 years and younger, to construct contemporary victim and offender profiles examining incident characteristics. Findings highlight the sex-based nature of the offense with unique victimization patterns across victims and offenders. Older <span class="hlt">brothers</span> using a firearm are the most frequent offenders against both male and female siblings. Strain as a theoretical foundation of siblicide is offered as an avenue for future inquiry. PMID:25069154</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/20055231','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/20055231"><span id="translatedtitle">The Sergent <span class="hlt">brothers</span> and the antimalarial campaigns in Algeria (1902-1948).</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Dedet, J-P</p> <p>2008-12-01</p> <p>Edmond and Etienne Sergent, "the Sergent <span class="hlt">brothers</span>", were both born in Algeria. They both studied medicine at the Algiers Medical School and then followed the Course of Microbiology of Emile Roux at the Institut Pasteur in Paris (1899-1900). From 1900, they were put in charge of a permanent mission aimed at antimalarial control in Algeria, which was supervised by the Institut Pasteur. The first campaign was carried out during the summer of 1902 at a station of the East Algerian Railway Company. The success of this mission lead to the creation of the Antimalaric Department of Algeria in 1904, which was directed by Etienne Sergent for the duration his life. This antimalarial programme was progressively extended to many other locations. The programme was optimized between 1927 and 1947, in the experimental field study of the Ouled Mendil Marsh, where global environmental measures and drainage lead to settlement of farms, the families of which did not suffered from malaria. At a time when neither insecticides nor synthetic antimalarial drug existed, antimalarial control measures that were developed tended to target human reservoirs and the mosquito vectors. The extension of the programme across the Algerian territory lead to a decrease of both malaria endemicity and extension of affected areas. PMID:20055231</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/7269275','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/7269275"><span id="translatedtitle">Health-hazard evaluation report HETA 87-121-1968, Riley <span class="hlt">Brothers</span>, Inc. , Burlington, Iowa</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Gupta, S.; Kramkowski, R.; Salisbury, S.</p> <p>1989-01-01</p> <p>A study was made of possible hazardous working conditions at Riley <span class="hlt">Brothers</span>, Inc., Burlington, Iowa. Concern centered around the possibility that certain production workers were exposed to various solvents and that the solvent levels measured in their blood tests were quite varied in nature. The company manufactured paint for different uses according to customer specifications. Major products included formulations of solvent-based paints, and spray painting or dip painting of metal parts. Waterproofing material composed of coal-tar pitch was also made here for use by roofers. One paint formulator had a combined exposure to naphtha and xylene that was 1.7 times the recommended exposure limit. Short term exposures to xylene for two paint strippers were 157 and 173 parts per million (ppm) which exceeded the 150 ppm recommended level. Urinary methyl-hippuric-acid concentrations before and after work shifts indicated a cross shift change greater than 1500 milligrams/gram creatinine which corresponded to an air level of xylene exceeding 100 ppm. Some workers are at risk of developing adverse health effects. Improvements in the ventilation system, use of organic vapor respirators, and use of proper respiratory protection during specified projects are recommended.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27068058','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27068058"><span id="translatedtitle"><span class="hlt">Big</span> data for bipolar disorder.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Monteith, Scott; Glenn, Tasha; Geddes, John; Whybrow, Peter C; Bauer, Michael</p> <p>2016-12-01</p> <p>The delivery of psychiatric care is changing with a new emphasis on integrated care, preventative measures, population health, and the biological basis of disease. Fundamental to this transformation are <span class="hlt">big</span> data and advances in the ability to analyze these data. The impact of <span class="hlt">big</span> data on the routine treatment of bipolar disorder today and in the near future is discussed, with examples that relate to health policy, the discovery of new associations, and the study of rare events. The primary sources of <span class="hlt">big</span> data today are electronic medical records (EMR), claims, and registry data from providers and payers. In the near future, data created by patients from active monitoring, passive monitoring of Internet and smartphone activities, and from sensors may be integrated with the EMR. Diverse data sources from outside of medicine, such as government financial data, will be linked for research. Over the long term, genetic and imaging data will be integrated with the EMR, and there will be more emphasis on predictive models. Many technical challenges remain when analyzing <span class="hlt">big</span> data that relates to size, heterogeneity, complexity, and unstructured text data in the EMR. Human judgement and subject matter expertise are critical parts of <span class="hlt">big</span> data analysis, and the active participation of psychiatrists is needed throughout the analytical process. PMID:27068058</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26077871','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26077871"><span id="translatedtitle">[<span class="hlt">Big</span> data in official statistics].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Zwick, Markus</p> <p>2015-08-01</p> <p>The concept of "<span class="hlt">big</span> data" stands to change the face of official statistics over the coming years, having an impact on almost all aspects of data production. The tasks of future statisticians will not necessarily be to produce new data, but rather to identify and make use of existing data to adequately describe social and economic phenomena. Until <span class="hlt">big</span> data can be used correctly in official statistics, a lot of questions need to be answered and problems solved: the quality of data, data protection, privacy, and the sustainable availability are some of the more pressing issues to be addressed. The essential skills of official statisticians will undoubtedly change, and this implies a number of challenges to be faced by statistical education systems, in universities, and inside the statistical offices. The national statistical offices of the European Union have concluded a concrete strategy for exploring the possibilities of <span class="hlt">big</span> data for official statistics, by means of the <span class="hlt">Big</span> Data Roadmap and Action Plan 1.0. This is an important first step and will have a significant influence on implementing the concept of <span class="hlt">big</span> data inside the statistical offices of Germany. PMID:26077871</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2014AGUFMIN14B..03N','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2014AGUFMIN14B..03N"><span id="translatedtitle">GEOSS: Addressing <span class="hlt">Big</span> Data Challenges</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Nativi, S.; Craglia, M.; Ochiai, O.</p> <p>2014-12-01</p> <p>In the sector of Earth Observation, the explosion of data is due to many factors including: new satellite constellations, the increased capabilities of sensor technologies, social media, crowdsourcing, and the need for multidisciplinary and collaborative research to face Global Changes. In this area, there are many expectations and concerns about <span class="hlt">Big</span> Data. Vendors have attempted to use this term for their commercial purposes. It is necessary to understand whether <span class="hlt">Big</span> Data is a radical shift or an incremental change for the existing digital infrastructures. This presentation tries to explore and discuss the impact of <span class="hlt">Big</span> Data challenges and new capabilities on the Global Earth Observation System of Systems (GEOSS) and particularly on its common digital infrastructure called GCI. GEOSS is a global and flexible network of content providers allowing decision makers to access an extraordinary range of data and information at their desk. The impact of the <span class="hlt">Big</span> Data dimensionalities (commonly known as 'V' axes: volume, variety, velocity, veracity, visualization) on GEOSS is discussed. The main solutions and experimentation developed by GEOSS along these axes are introduced and analyzed. GEOSS is a pioneering framework for global and multidisciplinary data sharing in the Earth Observation realm; its experience on <span class="hlt">Big</span> Data is valuable for the many lessons learned.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25985782','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25985782"><span id="translatedtitle">"If I only touch her cloak": the <span class="hlt">Sisters</span> of Charity of St. Joseph in New Orleans hospital, 1834-1860.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Kong, Hyejung Grace; Kim, Ock-Joo</p> <p>2015-04-01</p> <p>This study is about the <span class="hlt">Sisters</span> of Charity of St. Joseph in New Orleans' Charity Hospital during the years between 1834 and 1860. The <span class="hlt">Sisters</span> of Charity of St. Joseph was founded in 1809 by Saint Elizabeth Ann Bailey Seton (first native-born North American canonized in 1975) in Emmitsburg, Maryland. Seton's <span class="hlt">Sisters</span> of Charity was the first community for religious women to be established in the United States and was later incorporated with the French Daughters of Charity of St. Vincent de Paul in 1850. A call to work in New Orleans' Charity Hospital in the 1830s meant a significant achievement for the <span class="hlt">Sisters</span> of Charity, since it was the second oldest continuously operating public hospitals in the United States until 2005, bearing the same name over the decades. In 1834, <span class="hlt">Sister</span> Regina Smith and other <span class="hlt">sisters</span> were officially called to Charity Hospital, in order to supersede the existing "nurses, attendants, and servants," and take a complete charge of the internal management of Charity Hospital. The existing scholarship on the history of hospitals and Catholic nursing has not integrated the concrete stories of the <span class="hlt">Sisters</span> of Charity into the broader histories of institutionalized medicine, gender, and religion. Along with a variety of primary sources, this study primarily relies on the Charity Hospital History Folder stored at the Daughters of Charity West Center Province Archives. Located in the "Queen city of the South," Charity Hospital was the center of the southern medical profession and the world's fair of people and diseases. Charity Hospital provided the <span class="hlt">sisters</span> with a unique situation that religion and medicine became intertwined. The <span class="hlt">Sisters</span>, as nurses, constructed a new atmosphere of caring for patients and even their families inside and outside the hospital, and built their own separate space within the hospital walls. As hospital managers, the <span class="hlt">Sisters</span> of Charity were put in complete charge of the hospital, which was never seen in other hospitals. By</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4764575"><span id="translatedtitle">Super-resolution kinetochore tracking reveals the mechanisms of human <span class="hlt">sister</span> kinetochore directional switching</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Burroughs, Nigel J; Harry, Edward F; McAinsh, Andrew D</p> <p>2015-01-01</p> <p>The congression of chromosomes to the spindle equator involves the directed motility of bi-orientated <span class="hlt">sister</span> kinetochores. <span class="hlt">Sister</span> kinetochores bind bundles of dynamic microtubules and are physically connected through centromeric chromatin. A crucial question is to understand how <span class="hlt">sister</span> kinetochores are coordinated to generate motility and directional switches. Here, we combine super-resolution tracking of kinetochores with automated switching-point detection to analyse <span class="hlt">sister</span> switching dynamics over thousands of events. We discover that switching is initiated by both the leading (microtubules depolymerising) or trailing (microtubules polymerising) kinetochore. Surprisingly, trail-driven switching generates an overstretch of the chromatin that relaxes over the following half-period. This rules out the involvement of a tension sensor, the central premise of the long-standing tension-model. Instead, our data support a model in which clocks set the intrinsic-switching time of the two kinetochore-attached microtubule fibres, with the centromeric spring tension operating as a feedback to slow or accelerate the clocks. DOI: http://dx.doi.org/10.7554/eLife.09500.001 PMID:26460545</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED266892','ERIC'); return false;" href="http://eric.ed.gov/?q=little+AND+sister&pg=2&id=ED266892"><span id="translatedtitle">Walking with Grandfather and Great Wolf and Little Mouse <span class="hlt">Sister</span>. Teacher's Guide.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Lethbridge Univ. (Alberta).</p> <p></p> <p>Written for use with videotaped versions of the stories "Walking with Grandfather" and "Great Wolf and Little Mouse <span class="hlt">Sister</span>," this guide presents 20 lessons that teachers can adapt for students of various ages and use in integrated units or other curriculum approaches. The introductory material describes the use and philosophy of the video stories,…</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_18");'>18</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li class="active"><span>20</span></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_20 --> <div id="page_21" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="401"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4426464"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Whelan, Nathan V.; Kocot, Kevin M.; Moroz, Leonid L.</p> <p>2015-01-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567','ERIC'); return false;" href="http://eric.ed.gov/?q=turner%27s+AND+syndrome&pg=2&id=EJ579567"><span id="translatedtitle">Social Functioning among Girls with Fragile X or Turner Syndrome and Their <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Mazzocco, Michele M. M.; Baumgardner, Thomas; Freund, Lisa S.; Reiss, Allan L.</p> <p>1998-01-01</p> <p>Social behaviors among girls (ages 6-16) with fragile X (n=8) or Turner syndrome (n=9) were examined to address the role of family environment versus biological determinants of social dysfunction. Compared to their <span class="hlt">sisters</span>, subjects had lower IQS and higher rating of social and attention problems. (Author/CR)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ1006061.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ1006061.pdf"><span id="translatedtitle">Catherine Spalding: Co-Foundress of the <span class="hlt">Sisters</span> of Charity of Nazareth</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Shaughnessy, Mary Angela</p> <p>2006-01-01</p> <p>The <span class="hlt">Sisters</span> of Charity of Nazareth (SCN) maintain a vibrant presence in ministry in the US. This article presents an overview of their co-foundress, Catherine Spalding, and shows Mother Catherine to be the creative, mission-driven, and articulate leader that is still very much in need in today's society.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25902535','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25902535"><span id="translatedtitle">Error, signal, and the placement of Ctenophora <span class="hlt">sister</span> to all other animals.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Whelan, Nathan V; Kocot, Kevin M; Moroz, Leonid L; Halanych, Kenneth M</p> <p>2015-05-01</p> <p>Elucidating relationships among early animal lineages has been difficult, and recent phylogenomic analyses place Ctenophora <span class="hlt">sister</span> to all other extant animals, contrary to the traditional view of Porifera as the earliest-branching animal lineage. To date, phylogenetic support for either ctenophores or sponges as <span class="hlt">sister</span> to other animals has been limited and inconsistent among studies. Lack of agreement among phylogenomic analyses using different data and methods obscures how complex traits, such as epithelia, neurons, and muscles evolved. A consensus view of animal evolution will not be accepted until datasets and methods converge on a single hypothesis of early metazoan relationships and putative sources of systematic error (e.g., long-branch attraction, compositional bias, poor model choice) are assessed. Here, we investigate possible causes of systematic error by expanding taxon sampling with eight novel transcriptomes, strictly enforcing orthology inference criteria, and progressively examining potential causes of systematic error while using both maximum-likelihood with robust data partitioning and Bayesian inference with a site-heterogeneous model. We identified ribosomal protein genes as possessing a conflicting signal compared with other genes, which caused some past studies to infer ctenophores and cnidarians as <span class="hlt">sister</span>. Importantly, biases resulting from elevated compositional heterogeneity or elevated substitution rates are ruled out. Placement of ctenophores as <span class="hlt">sister</span> to all other animals, and sponge monophyly, are strongly supported under multiple analyses, herein. PMID:25902535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=summer+AND+camp+AND+benefits&pg=3&id=EJ587581','ERIC'); return false;" href="http://eric.ed.gov/?q=summer+AND+camp+AND+benefits&pg=3&id=EJ587581"><span id="translatedtitle"><span class="hlt">Sisters</span> in Science: An Intergenerational Science Program for Elementary School Girls.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.</p> <p>1998-01-01</p> <p>Once a week, several classrooms of Philadelphia 4th-grade girls participate in <span class="hlt">Sisters</span> in Science, an afterschool, intergenerational program sponsored by Temple University that provides hand-on activities exploring urban environmental issues. A two-week summer camp program helps these students explore the rivers of Philadelphia. Participants…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=testimonio&pg=3&id=EJ903417','ERIC'); return false;" href="http://eric.ed.gov/?q=testimonio&pg=3&id=EJ903417"><span id="translatedtitle">Transitioning from Doctoral Study to the Academy: Theorizing "Trenzas" of Identity for Latina <span class="hlt">Sister</span> Scholars</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Espino, Michelle M.; Munoz, Susana M.; Kiyama, Judy Marquez</p> <p>2010-01-01</p> <p>This article focuses on multiple truths pertaining to doctoral education as expressed by three Latina doctoral recipients. These scholars successfully navigated various educational processes with the support of one another, their families, faculty, and their chosen discipline. The authors, as <span class="hlt">sister</span> scholars, retell their educational journeys…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3955356"><span id="translatedtitle">Spotlights on our <span class="hlt">sister</span> journals: ChemistryOpen 1/2014</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2014-01-01</p> <p>On these pages, we feature a selection of the excellent work that has recently been published in our <span class="hlt">sister</span> journals. If you are reading these pages on a computer, click on any of the items to read the full article. Otherwise please see the DOIs for easy online access through Wiley Online Library. PMID:24688888</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=bilingual+AND+children+AND+home&pg=5&id=EJ997719','ERIC'); return false;" href="http://eric.ed.gov/?q=bilingual+AND+children+AND+home&pg=5&id=EJ997719"><span id="translatedtitle">A Tale of Three <span class="hlt">Sisters</span>: Language Ideologies, Identities, and Negotiations in a Bilingual, Transnational Family</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>King, Kendall A.</p> <p>2013-01-01</p> <p>This longitudinal case study investigated how linguistic identity was constructed, constrained, and performed by three <span class="hlt">sisters</span>, aged 1, 12, and 17, within one bilingual, transnational Ecuadorian-U.S. family. Data were collected over 14 months through weekly home visits that included participant observation, informal interviews, and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4728446','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4728446"><span id="translatedtitle">Overlap microtubules link <span class="hlt">sister</span> k-fibres and balance the forces on bi-oriented kinetochores</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Kajtez, Janko; Solomatina, Anastasia; Novak, Maja; Polak, Bruno; Vukušić, Kruno; Rüdiger, Jonas; Cojoc, Gheorghe; Milas, Ana; Šumanovac Šestak, Ivana; Risteski, Patrik; Tavano, Federica; Klemm, Anna H.; Roscioli, Emanuele; Welburn, Julie; Cimini, Daniela; Glunčić, Matko; Pavin, Nenad; Tolić, Iva M.</p> <p>2016-01-01</p> <p>During metaphase, forces on kinetochores are exerted by k-fibres, bundles of microtubules that end at the kinetochore. Interestingly, non-kinetochore microtubules have been observed between <span class="hlt">sister</span> kinetochores, but their function is unknown. Here we show by laser-cutting of a k-fibre in HeLa and PtK1 cells that a bundle of non-kinetochore microtubules, which we term ‘bridging fibre', bridges <span class="hlt">sister</span> k-fibres and balances the interkinetochore tension. We found PRC1 and EB3 in the bridging fibre, suggesting that it consists of antiparallel dynamic microtubules. By using a theoretical model that includes a bridging fibre, we show that the forces at the pole and at the kinetochore depend on the bridging fibre thickness. Moreover, our theory and experiments show larger relaxation of the interkinetochore distance for cuts closer to kinetochores. We conclude that the bridging fibre, by linking <span class="hlt">sister</span> k-fibres, withstands the tension between <span class="hlt">sister</span> kinetochores and enables the spindle to obtain a curved shape. PMID:26728792</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol16/pdf/CFR-2010-title40-vol16-sec79-65.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title40-vol16/pdf/CFR-2010-title40-vol16-sec79-65.pdf"><span id="translatedtitle">40 CFR 79.65 - In vivo <span class="hlt">sister</span> chromatid exchange assay.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-07-01</p> <p>... references should be consulted. (1) 40 CFR 798.5915, In vivo <span class="hlt">Sister</span> Chromatid Exchange Assay. (2) Kato, H... peripheral blood lymphocytes, often from rodent species. (b) Definitions. For the purposes of this section... the end of the exposure period and blood lymphocyte cell cultures are prepared from study...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6704889','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6704889"><span id="translatedtitle">Do <span class="hlt">sister</span> forks of bidirectionally growing replicons proceed at unequal rates</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dubey, D.D.; Raman, R.</p> <p>1987-02-01</p> <p>DNA fibre autoradiography in different tissues of the rodents Bandicota bengalensis and Nesokia indica reveals a high frequency of such bidirectionally replicating replicons whose <span class="hlt">sister</span> hot tracks are of unequal size. These results suggest intrarepliconic difference in the rates of fork migration in the two directions.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780','ERIC'); return false;" href="http://eric.ed.gov/?q=Weed&pg=3&id=EJ797780"><span id="translatedtitle">Three <span class="hlt">Sisters</span>: Lessons of Traditional Story Honored in Assessment and Accreditation</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenault, Venida S.</p> <p>2008-01-01</p> <p>The three <span class="hlt">sisters</span> story is shared across many tribes. It explains the practice of planting corn, beans, and squash together. The corn stalks provide support for the bean vines; the beans provide nitrogen for the corn; and the squash prevents weed growth between the mounds. Such stories explain not only the science of agricultural methods in tribal…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=258716','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=258716"><span id="translatedtitle">A <span class="hlt">sister</span> group metabolomic contrast delineates the biochemical regulation underlying desiccation tolerance in Sporobolus stapfianus</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p>Understanding how plant cells tolerate dehydration is a vital prerequisite for developing strategies for improving drought tolerance. The desiccation tolerant grass Sporobolus stapfianus and the desiccation sensitive S. pyramidalis were used to form a <span class="hlt">sister</span>-group contrast to reveal adaptive metabo...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/14984173','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/14984173"><span id="translatedtitle">Capillaria philippinensis: a cause of fatal diarrhea in one of two infected Egyptian <span class="hlt">sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>el-Karaksy, Hanaa; el-Shabrawi, Mortada; Mohsen, Nabil; Kotb, Magd; el-Koofy, Nehal; el-Deeb, Nadia</p> <p>2004-02-01</p> <p>Capillaria philippinensis is an emerging infection in Egypt. Reports in children are scarce. We report here two <span class="hlt">sisters</span> with C. philippinensis infection, aged 8 and 12 years. Their father was a fisherman and they had a habit of picking small pieces of uncooked fish to eat while their mother prepared their meals. They came from El-Menia governorate, which lies in the northern part of Upper Egypt. Most reported cases from Egypt come from this governorate and nearby areas. Both <span class="hlt">sisters</span> had persistent profuse watery diarrhea of 12 months' duration. Their weights were below the 5th percentile for age. Both were hypoalbuminemic, but only the younger had pedal edema. Both had hypokalemia and hyponatremia. During the course of their illness they were repeatedly admitted to different hospitals and received intravenous fluids, but the correct diagnosis was not reached. Diagnosis was made by stool examination at our hospital when eggs and larvae were detected in stool samples. Although a diagnosis was promptly made, the older <span class="hlt">sister</span> who suffered from pneumonia and septic shock unfortunately died a few days after admission. The younger <span class="hlt">sister</span> was treated successfully with albendazole 200 mg twice daily. Diarrhea abated, pedal edema disappeared, and she started to gain weight. PMID:14984173</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066400','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4066400"><span id="translatedtitle">Tension-dependent removal of pericentromeric shugoshin is an indicator of <span class="hlt">sister</span> chromosome biorientation</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Nerusheva, Olga O.; Galander, Stefan; Fernius, Josefin; Kelly, David; Marston, Adele L.</p> <p>2014-01-01</p> <p>During mitosis and meiosis, <span class="hlt">sister</span> chromatid cohesion resists the pulling forces of microtubules, enabling the generation of tension at kinetochores upon chromosome biorientation. How tension is read to signal the bioriented state remains unclear. Shugoshins form a pericentromeric platform that integrates multiple functions to ensure proper chromosome biorientation. Here we show that budding yeast shugoshin Sgo1 dissociates from the pericentromere reversibly in response to tension. The antagonistic activities of the kinetochore-associated Bub1 kinase and the Sgo1-bound phosphatase protein phosphatase 2A (PP2A)-Rts1 underlie a tension-dependent circuitry that enables Sgo1 removal upon <span class="hlt">sister</span> kinetochore biorientation. Sgo1 dissociation from the pericentromere triggers dissociation of condensin and Aurora B from the centromere, thereby stabilizing the bioriented state. Conversely, forcing <span class="hlt">sister</span> kinetochores to be under tension during meiosis I leads to premature Sgo1 removal and precocious loss of pericentromeric cohesion. Overall, we show that the pivotal role of shugoshin is to build a platform at the pericentromere that attracts activities that respond to the absence of tension between <span class="hlt">sister</span> kinetochores. Disassembly of this platform in response to intersister kinetochore tension signals the bioriented state. Therefore, tension sensing by shugoshin is a central mechanism by which the bioriented state is read. PMID:24939933</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=chess&pg=3&id=EJ939604','ERIC'); return false;" href="http://eric.ed.gov/?q=chess&pg=3&id=EJ939604"><span id="translatedtitle">Does High-Level Intellectual Performance Depend on Practice Alone? Debunking the Polgar <span class="hlt">Sisters</span> Case</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Howard, Robert W.</p> <p>2011-01-01</p> <p>The famous Polgar <span class="hlt">sisters</span> started chess very young, undertook extensive study, and two became grandmasters. This case often is cited as decisive evidence that practice alone is key in development of expertise, that innate talent is unimportant or non-existent, and that almost anyone can become a grandmaster. But on close examination these claims…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=43487&keyword=cyclophosphamide&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=76238155&CFTOKEN=59583677"><span id="translatedtitle">EVIDENCE FOR THE CHROMOSOMAL REPLICONS AS UNITS OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>Current hypotheses of <span class="hlt">sister</span> chromatid exchange (SCE) formation postulate that sites of SCE induction are associated with active replicons or replicon clusters. We have applied the FCC-SCD technique to in vivo studies of mouse bone marrow cells that have been treated with cycloph...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3914784','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=3914784"><span id="translatedtitle">Cytochrome b Divergence between Avian <span class="hlt">Sister</span> Species Is Linked to Generation Length and Body Mass</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Thomson, Caroline E.; Gilbert, James D. J.; Brooke, M. de L</p> <p>2014-01-01</p> <p>It is increasingly realised that the molecular clock does not tick at a constant rate. Rather, mitochondrial mutation rates are influenced by factors such as generation length and body mass. This has implications for the use of genetic data in species delimitation. It could be that speciation, as recognised by avian taxonomists, is associated with a certain minimum genetic distance between <span class="hlt">sister</span> taxa, in which case we would predict no difference in the cytochrome b divergence of <span class="hlt">sister</span> taxa according to the species' body size or generation time. Alternatively, if what taxonomists recognise as speciation has tended to be associated with the passage of a minimum amount of time since divergence, then there might be less genetic divergence between <span class="hlt">sister</span> taxa with slower mutation rates, namely those that are heavier and/or with longer generation times. After excluding non-flying species, we analysed a database of over 600 avian <span class="hlt">sister</span> species pairs, and found that species pairs with longer generation lengths (which tend to be the larger species) showed less cytochrome b divergence. This finding cautions against using any simple unitary criterion of genetic divergence to delimit species. PMID:24505250</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/827476','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/827476"><span id="translatedtitle">Los Alamos National Laboratory's <span class="hlt">Sister</span> Laboratory Collaborations on Low and Intermediate Level Radioactive Waste Management</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Newell, D. L.; Sinkule, B. J.; Apt, K. E.</p> <p>2003-02-25</p> <p>The DOE/National Nuclear Security Administration's (NNSA) ''<span class="hlt">Sister</span> Laboratory'' program allows for bilateral technical cooperation in peaceful uses of nuclear energy for developing nations. The program establishes a direct line of communication between U.S. scientists and the nuclear research and scientific communities in participating countries.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1017170','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1017170"><span id="translatedtitle">Two <span class="hlt">sisters</span> with mental retardation, cataract, ataxia, progressive hearing loss, and polyneuropathy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Begeer, J H; Scholte, F A; van Essen, A J</p> <p>1991-01-01</p> <p>Two <span class="hlt">sisters</span> are described with a disorder characterised by mental retardation, congenital cataract, progressive spinocerebellar ataxia, sensorineural deafness, and signs of peripheral neuropathy. Progressive hearing loss, ataxia, and polyneuropathy became evident in the third decade. The differential diagnosis of this syndrome is discussed including the syndromes described by Berman et al and Koletzko et al. PMID:1661780</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_19");'>19</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li class="active"><span>21</span></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_21 --> <div id="page_22" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="421"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/ED452094.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/ED452094.pdf"><span id="translatedtitle"><span class="hlt">Sisters</span> in Science: Using Sports as a Vehicle for Science Learning.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Hammrich, Penny L.; Richardson, Greer M.; Green, Tina Sloan; Livingston, Beverly</p> <p></p> <p>This paper describes a project for upper elementary and middle school minority girl students called the <span class="hlt">Sisters</span> in Sport Science (SISS). The SISS program addresses the needs of urban girls in gaining access to equal education in science and mathematics by using athletics as a vehicle for learning. The program provides a non-competitive and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Teenage+AND+pregnancy&pg=5&id=EJ965819','ERIC'); return false;" href="http://eric.ed.gov/?q=Teenage+AND+pregnancy&pg=5&id=EJ965819"><span id="translatedtitle">Youths' Caretaking of Their Adolescent <span class="hlt">Sisters</span>' Children: Its Costs and Benefits for Youths' Development</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>East, Patricia L.; Weisner, Thomas S.; Reyes, Barbara T.</p> <p>2006-01-01</p> <p>This study examined how time spent caring for a teenage <span class="hlt">sister</span>'s child and experiences in providing care related to youths' young adult outcomes. Latino and African American youths (N = 108) were studied during middle and late adolescence. Results indicated that youths who provided many hours of child care were more stressed and had lower school…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531','ERIC'); return false;" href="http://eric.ed.gov/?q=moral+AND+enhancement&id=EJ755531"><span id="translatedtitle">Meanings of Sisterhood and Developmental Disability: Narratives from White Nondisabled <span class="hlt">Sisters</span></span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>McGraw, Lori A.; Walker, Alexis J.</p> <p>2007-01-01</p> <p>Integrating thought from critical feminist and disability theorists via a strategic social constructionist perspective, the authors analyzed 10 in-depth qualitative interviews to begin to understand the dialogue between (a) how nondisabled <span class="hlt">sisters</span> understand themselves and their siblings with developmental disabilities and (b) wider systems of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&id=ED530841','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&id=ED530841"><span id="translatedtitle">When the <span class="hlt">Sisters</span> Said Farewell: The Transition of Leadership in Catholic Elementary Schools</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Caruso, Michael P., S.J.</p> <p>2012-01-01</p> <p>"When the <span class="hlt">Sisters</span> Said Farewell" tells an important story of the contributions of Catholic elementary schools to the United States by chronicling the experiences and insights of religious women (nuns) who were the last members of their communities to serve in parish elementary schools, and of those lay men and women who were the first to serve in…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=7&id=EJ406575','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=7&id=EJ406575"><span id="translatedtitle">Characteristics of Alcoholism among Catholic <span class="hlt">Sisters</span>: Results of a National Survey.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Spiegel, Virginia M.</p> <p>1989-01-01</p> <p>Obtained information on addiction history, intervention and treatment, and family and community patterns from 221 Catholic <span class="hlt">Sisters</span> in residential treatment for alcoholism. Findings suggest that, although respondents were similar to other women in their vulnerability to addiction, they carried added burdens because of societal expectations of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=nuns&pg=6&id=EJ1078896','ERIC'); return false;" href="http://eric.ed.gov/?q=nuns&pg=6&id=EJ1078896"><span id="translatedtitle">Teaching <span class="hlt">Sisters</span> and Transnational Networks: Recruitment and Education Expansion in the Long Nineteenth Century</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Raftery, Deirdre</p> <p>2015-01-01</p> <p>This article examines the management of the education enterprise of teaching <span class="hlt">Sisters</span>, with reference to their transnational networking. The article suggests that orders of women religious were the first all-female transnational networks, engaged constantly in work that was characterised by "movement, ebb and circulation". The mobility of…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=new&pg=6&id=EJ1048143','ERIC'); return false;" href="http://eric.ed.gov/?q=new&pg=6&id=EJ1048143"><span id="translatedtitle">They Came with a Purpose: Educational Journeys of Nineteenth-Century Irish Dominican <span class="hlt">Sister</span> Teachers</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Collins, Jenny</p> <p>2015-01-01</p> <p>Irish Catholic teaching <span class="hlt">sisters</span> were major actors in the development of education systems in New World countries such as the United States, Canada, South Africa, Australia and New Zealand. Immigrants themselves, they faced a number of key challenges as they sought to adapt Old World cultural and educational ideas to the education of the immigrant…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=neuroscience+AND+music&pg=2&id=EJ1003992','ERIC'); return false;" href="http://eric.ed.gov/?q=neuroscience+AND+music&pg=2&id=EJ1003992"><span id="translatedtitle">Empirical Psycho-Aesthetics and Her <span class="hlt">Sisters</span>: Substantive and Methodological Issues--Part II</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Konecni, Vladimir J.</p> <p>2013-01-01</p> <p>Empirical psycho-aesthetics is approached in this two-part article from two directions. Part I, which appeared in the Winter 2012 issue of "JAE," addressed definitional and organizational issues, including the field's origins, its relation to "<span class="hlt">sister</span>" disciplines (experimental philosophy, cognitive neuroscience of art, and neuroaesthetics), and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503556','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4503556"><span id="translatedtitle"><span class="hlt">Big</span> Data Analytics in Healthcare</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Belle, Ashwin; Thiagarajan, Raghuram; Soroushmehr, S. M. Reza; Navidi, Fatemeh; Beard, Daniel A.; Najarian, Kayvan</p> <p>2015-01-01</p> <p>The rapidly expanding field of <span class="hlt">big</span> data analytics has started to play a pivotal role in the evolution of healthcare practices and research. It has provided tools to accumulate, manage, analyze, and assimilate large volumes of disparate, structured, and unstructured data produced by current healthcare systems. <span class="hlt">Big</span> data analytics has been recently applied towards aiding the process of care delivery and disease exploration. However, the adoption rate and research development in this space is still hindered by some fundamental problems inherent within the <span class="hlt">big</span> data paradigm. In this paper, we discuss some of these major challenges with a focus on three upcoming and promising areas of medical research: image, signal, and genomics based analytics. Recent research which targets utilization of large volumes of medical data while combining multimodal data from disparate sources is discussed. Potential areas of research within this field which have the ability to provide meaningful impact on healthcare delivery are also examined. PMID:26229957</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4494865','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4494865"><span id="translatedtitle"><span class="hlt">Big</span> Data: Astronomical or Genomical?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Stephens, Zachary D.; Lee, Skylar Y.; Faghri, Faraz; Campbell, Roy H.; Zhai, Chengxiang; Efron, Miles J.; Iyer, Ravishankar; Schatz, Michael C.; Sinha, Saurabh; Robinson, Gene E.</p> <p>2015-01-01</p> <p>Genomics is a <span class="hlt">Big</span> Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other <span class="hlt">Big</span> Data domains. Projecting to the year 2025, we compared genomics with three other major generators of <span class="hlt">Big</span> Data: astronomy, YouTube, and Twitter. Our estimates show that genomics is a “four-headed beast”—it is either on par with or the most demanding of the domains analyzed here in terms of data acquisition, storage, distribution, and analysis. We discuss aspects of new technologies that will need to be developed to rise up and meet the computational challenges that genomics poses for the near future. Now is the time for concerted, community-wide planning for the “genomical” challenges of the next decade. PMID:26151137</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26151137','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26151137"><span id="translatedtitle"><span class="hlt">Big</span> Data: Astronomical or Genomical?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stephens, Zachary D; Lee, Skylar Y; Faghri, Faraz; Campbell, Roy H; Zhai, Chengxiang; Efron, Miles J; Iyer, Ravishankar; Schatz, Michael C; Sinha, Saurabh; Robinson, Gene E</p> <p>2015-07-01</p> <p>Genomics is a <span class="hlt">Big</span> Data science and is going to get much bigger, very soon, but it is not known whether the needs of genomics will exceed other <span class="hlt">Big</span> Data domains. Projecting to the year 2025, we compared genomics with three other major generators of <span class="hlt">Big</span> Data: astronomy, YouTube, and Twitter. Our estimates show that genomics is a "four-headed beast"--it is either on par with or the most demanding of the domains analyzed here in terms of data acquisition, storage, distribution, and analysis. We discuss aspects of new technologies that will need to be developed to rise up and meet the computational challenges that genomics poses for the near future. Now is the time for concerted, community-wide planning for the "genomical" challenges of the next decade. PMID:26151137</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26229957','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26229957"><span id="translatedtitle"><span class="hlt">Big</span> Data Analytics in Healthcare.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Belle, Ashwin; Thiagarajan, Raghuram; Soroushmehr, S M Reza; Navidi, Fatemeh; Beard, Daniel A; Najarian, Kayvan</p> <p>2015-01-01</p> <p>The rapidly expanding field of <span class="hlt">big</span> data analytics has started to play a pivotal role in the evolution of healthcare practices and research. It has provided tools to accumulate, manage, analyze, and assimilate large volumes of disparate, structured, and unstructured data produced by current healthcare systems. <span class="hlt">Big</span> data analytics has been recently applied towards aiding the process of care delivery and disease exploration. However, the adoption rate and research development in this space is still hindered by some fundamental problems inherent within the <span class="hlt">big</span> data paradigm. In this paper, we discuss some of these major challenges with a focus on three upcoming and promising areas of medical research: image, signal, and genomics based analytics. Recent research which targets utilization of large volumes of medical data while combining multimodal data from disparate sources is discussed. Potential areas of research within this field which have the ability to provide meaningful impact on healthcare delivery are also examined. PMID:26229957</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26614539','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26614539"><span id="translatedtitle">[<span class="hlt">Big</span> Data- challenges and risks].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Krauß, Manuela; Tóth, Tamás; Hanika, Heinrich; Kozlovszky, Miklós; Dinya, Elek</p> <p>2015-12-01</p> <p>The term "<span class="hlt">Big</span> Data" is commonly used to describe the growing mass of information being created recently. New conclusions can be drawn and new services can be developed by the connection, processing and analysis of these information. This affects all aspects of life, including health and medicine. The authors review the application areas of <span class="hlt">Big</span> Data, and present examples from health and other areas. However, there are several preconditions of the effective use of the opportunities: proper infrastructure, well defined regulatory environment with particular emphasis on data protection and privacy. These issues and the current actions for solution are also presented. PMID:26614539</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Greek+AND+Art&pg=3&id=EJ903965','ERIC'); return false;" href="http://eric.ed.gov/?q=Greek+AND+Art&pg=3&id=EJ903965"><span id="translatedtitle">Little Science to <span class="hlt">Big</span> Science: <span class="hlt">Big</span> Scientists to Little Scientists?</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Simonton, Dean Keith</p> <p>2010-01-01</p> <p>This article presents the author's response to Hisham B. Ghassib's essay entitled "Where Does Creativity Fit into a Productivist Industrial Model of Knowledge Production?" Professor Ghassib's (2010) essay presents a provocative portrait of how the little science of the Babylonians, Greeks, and Arabs became the <span class="hlt">Big</span> Science of the modern industrial…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19920329','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19920329"><span id="translatedtitle">Legal consequences for torture in children cases: the Gomez Paquiyauri <span class="hlt">Brothers</span> vs Peru case.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Tinta, Monica Feria</p> <p>2009-01-01</p> <p>The Gomez Paquiyauri <span class="hlt">Brothers</span> case, before the Inter-American Court of Human Rights, was the first international case concerning the protection of children in the context of armed conflict where an international court stated the law concerning the duties of States towards children even in the context of war, and provided for reparations. As such it represents a landmark decision. The case arose from the illegal detention, torture and extrajudicial execution of two minors, Emilio and Rafael Gomez Paquiyauri, at the hands of Peruvian Police in 1991, under the Fujimori Administration at a time when the internal war in Peru was at its peak. Unlike most cases coming to the jurisdiction of the Inter-American Court, the case had been subject to domestic criminal investigations that had led to the convictions of two low ranking policemen. Yet a more subtle pattern of impunity lied at the root of the case. Torture had been denied by the State, and the prosecutions of low ranking policemen had intended to cover up the responsibility of those who ordered a policy of torture and executions (including the existence of secret codes for the torture and elimination of suspects of "terrorism") during the years of the internal armed conflict in Peru. The joint work of legal and medical expertise in the litigation of the case permitted the establishment of the facts and the law, obtaining an award of 740,500 dollars for the victims and a number of measures of reparation including guarantees of non-repetition and satisfaction, such as the naming of a school after the victims. PMID:19920329</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://medlineplus.gov/magazine/issues/sprsum10/articles/sprsum10pg25b.html','NIH-MEDLINEPLUS'); return false;" href="https://medlineplus.gov/magazine/issues/sprsum10/articles/sprsum10pg25b.html"><span id="translatedtitle">Tick-Borne Diseases: The <span class="hlt">Big</span> Two</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... Feature: Ticks and Diseases Tick-borne Diseases: The <span class="hlt">Big</span> Two Past Issues / Spring - Summer 2010 Table of ... to Remove a Tick / Tick-borne Diseases: The <span class="hlt">Big</span> Two Spring / Summer 2010 Issue: Volume 5 Number ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.nlm.nih.gov/medlineplus/news/fullstory_159241.html','NIH-MEDLINEPLUS'); return false;" href="https://www.nlm.nih.gov/medlineplus/news/fullstory_159241.html"><span id="translatedtitle">Do <span class="hlt">Big</span> Bottles Kickstart Infant Weight Issues?</span></a></p> <p><a target="_blank" href="http://medlineplus.gov/">MedlinePlus</a></p> <p></p> <p></p> <p>... nih.gov/medlineplus/news/fullstory_159241.html Do <span class="hlt">Big</span> Bottles Kickstart Infant Weight Issues? Smaller baby bottles ... 2016 (HealthDay News) -- Feeding babies formula from a <span class="hlt">big</span> bottle might put them at higher risk for ...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/1167036','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/1167036"><span id="translatedtitle"><span class="hlt">Big</span> Explosives Experimental Facility - BEEF</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>2014-10-31</p> <p>The <span class="hlt">Big</span> Explosives Experimental Facility or BEEF is a ten acre fenced high explosive testing facility that provides data to support stockpile stewardship and other national security programs. At BEEF conventional high explosives experiments are safely conducted providing sophisticated diagnostics such as high speed optics and x-ray radiography.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=paleontology&pg=5&id=EJ442132','ERIC'); return false;" href="http://eric.ed.gov/?q=paleontology&pg=5&id=EJ442132"><span id="translatedtitle">The Case for "<span class="hlt">Big</span> History."</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Christian, David</p> <p>1991-01-01</p> <p>Urges an approach to the teaching of history that takes the largest possible perspective, crossing time as well as space. Discusses the problems and advantages of such an approach. Describes a course on "<span class="hlt">big</span>" history that begins with time, creation myths, and astronomy, and moves on to paleontology and evolution. (DK)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004AAS...20512304G','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004AAS...20512304G"><span id="translatedtitle">Fossils of <span class="hlt">big</span> bang turbulence</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Gibson, C. H.</p> <p>2004-12-01</p> <p>A model is proposed connecting turbulence, fossil turbulence, and the <span class="hlt">big</span> bang origin of the universe. While details are incomplete, the model is consistent with our knowledge of these processes and is supported by observations. Turbulence arises in a hot-<span class="hlt">big</span>-bang quantum-gravitational-dynamics scenario at Planck scales. Chaotic, eddy-like-motions produce an exothermic Planck particle cascade from 10-35 m at 1032 K to 108 larger, 104 cooler, quark-gluon scales. A Planck-Kerr instability gives high-Reynolds-number (Re 106) turbulent combustion, space-time-energy-entropy and turbulent mixing. Batchelor-Obukhov-Corrsin turbulent-temperature fluctuations are preserved as the first fossil-turbulence by inflation stretching the patterns beyond the horizon ct of causal connection faster than light speed c in time t 10-33 seconds. Fossil-<span class="hlt">big</span>-bang-temperature-turbulence re-enters the horizon and imprints nucleosynthesis of H-He densities that seed fragmentation by gravity at 1012 s in the low Reynolds number plasma before its transition to gas at t 1013 s and T 3000 K. Multi-scaling coefficients of the cosmic-microwave-background (CMB) temperature anisotropies closely match those for high Reynolds number turbulence, Bershadskii and Sreenivasan 2002, 2003. CMB spectra support the interpretation that <span class="hlt">big</span>-bang-turbulence-fossils triggered fragmentation of the viscous plasma at supercluster to galaxy mass scales from 1046 to 1042 kg, Gibson 1996, 2000, 2004ab.</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_20");'>20</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li class="active"><span>22</span></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_22 --> <div id="page_23" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="441"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=turbo&id=EJ726234','ERIC'); return false;" href="http://eric.ed.gov/?q=turbo&id=EJ726234"><span id="translatedtitle"><span class="hlt">Big</span>6 Turbotools and Synthesis</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Tooley, Melinda</p> <p>2005-01-01</p> <p>The different tools that are helpful during the Synthesis stage, their role in boosting students abilities in Synthesis and the way in which it can be customized to meet the needs of each group of students are discussed. <span class="hlt">Big</span>6 TurboTools offers several tools to help complete the task. In Synthesis stage, these same tools along with Turbo Report and…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/sciencecinema/biblio/1167036','SCIGOVIMAGE-SCICINEMA'); return false;" href="http://www.osti.gov/sciencecinema/biblio/1167036"><span id="translatedtitle"><span class="hlt">Big</span> Explosives Experimental Facility - BEEF</span></a></p> <p><a target="_blank" href="http://www.osti.gov/sciencecinema/">ScienceCinema</a></p> <p>None</p> <p>2015-01-07</p> <p>The <span class="hlt">Big</span> Explosives Experimental Facility or BEEF is a ten acre fenced high explosive testing facility that provides data to support stockpile stewardship and other national security programs. At BEEF conventional high explosives experiments are safely conducted providing sophisticated diagnostics such as high speed optics and x-ray radiography.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://pubs.usgs.gov/gip/2006/35/','USGSPUBS'); return false;" href="http://pubs.usgs.gov/gip/2006/35/"><span id="translatedtitle">1976 <span class="hlt">Big</span> Thompson flood, Colorado</span></a></p> <p><a target="_blank" href="http://pubs.er.usgs.gov/pubs/index.jsp?view=adv">USGS Publications Warehouse</a></p> <p>Jarrett, R. D., (compiler); Vandas, S.J.</p> <p>2006-01-01</p> <p>In the early evening of July 31, 1976, a large stationary thunderstorm released as much as 7.5 inches of rainfall in about an hour (about 12 inches in a few hours) in the upper reaches of the <span class="hlt">Big</span> Thompson River drainage. This large amount of rainfall in such a short period of time produced a flash flood that caught residents and tourists by surprise. The immense volume of water that churned down the narrow <span class="hlt">Big</span> Thompson Canyon scoured the river channel and destroyed everything in its path, including 418 homes, 52 businesses, numerous bridges, paved and unpaved roads, power and telephone lines, and many other structures. The tragedy claimed the lives of 144 people. Scores of other people narrowly escaped with their lives. The <span class="hlt">Big</span> Thompson flood ranks among the deadliest of Colorado's recorded floods. It is one of several destructive floods in the United States that has shown the necessity of conducting research to determine the causes and effects of floods. The U.S. Geological Survey (USGS) conducts research and operates a Nationwide streamgage network to help understand and predict the magnitude and likelihood of large streamflow events such as the <span class="hlt">Big</span> Thompson Flood. Such research and streamgage information are part of an ongoing USGS effort to reduce flood hazards and to increase public awareness.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://files.eric.ed.gov/fulltext/EJ949549.pdf','ERIC'); return false;" href="http://files.eric.ed.gov/fulltext/EJ949549.pdf"><span id="translatedtitle">China: <span class="hlt">Big</span> Changes Coming Soon</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Rowen, Henry S.</p> <p>2011-01-01</p> <p><span class="hlt">Big</span> changes are ahead for China, probably abrupt ones. The economy has grown so rapidly for many years, over 30 years at an average of nine percent a year, that its size makes it a major player in trade and finance and increasingly in political and military matters. This growth is not only of great importance internationally, it is already having…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1042664','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1042664"><span id="translatedtitle">The <span class="hlt">Big</span>Boss Experiment</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Schelgel, D.; Abdalla, F.; Abraham, T.; Ahn, C.; Allende Prieto, C.; Annis, J.; Aubourg, E.; Azzaro, M.; Bailey, S.; Baltay, C.; Baugh, C.; Bebek, C.; Becerril, S.; Blanton, M.; Bolton, A.; Bromley, B.; Cahn, R.; Carton, P.-H.; Cervanted-Cota, J.L.; Chu, Y.; Cortes, M.; /APC, Paris /Brookhaven /IRFU, Saclay /Marseille, CPPM /Marseille, CPT /Durham U. / /IEU, Seoul /Fermilab /IAA, Granada /IAC, La Laguna / /IAC, Mexico / / /Madrid, IFT /Marseille, Lab. Astrophys. / / /New York U. /Valencia U.</p> <p>2012-06-07</p> <p><span class="hlt">Big</span>BOSS is a Stage IV ground-based dark energy experiment to study baryon acoustic oscillations (BAO) and the growth of structure with a wide-area galaxy and quasar redshift survey over 14,000 square degrees. It has been conditionally accepted by NOAO in response to a call for major new instrumentation and a high-impact science program for the 4-m Mayall telescope at Kitt Peak. The <span class="hlt">Big</span>BOSS instrument is a robotically-actuated, fiber-fed spectrograph capable of taking 5000 simultaneous spectra over a wavelength range from 340 nm to 1060 nm, with a resolution R = {lambda}/{Delta}{lambda} = 3000-4800. Using data from imaging surveys that are already underway, spectroscopic targets are selected that trace the underlying dark matter distribution. In particular, targets include luminous red galaxies (LRGs) up to z = 1.0, extending the BOSS LRG survey in both redshift and survey area. To probe the universe out to even higher redshift, <span class="hlt">Big</span>BOSS will target bright [OII] emission line galaxies (ELGs) up to z = 1.7. In total, 20 million galaxy redshifts are obtained to measure the BAO feature, trace the matter power spectrum at smaller scales, and detect redshift space distortions. <span class="hlt">Big</span>BOSS will provide additional constraints on early dark energy and on the curvature of the universe by measuring the Ly-alpha forest in the spectra of over 600,000 2.2 < z < 3.5 quasars. <span class="hlt">Big</span>BOSS galaxy BAO measurements combined with an analysis of the broadband power, including the Ly-alpha forest in <span class="hlt">Big</span>BOSS quasar spectra, achieves a FOM of 395 with Planck plus Stage III priors. This FOM is based on conservative assumptions for the analysis of broad band power (k{sub max} = 0.15), and could grow to over 600 if current work allows us to push the analysis to higher wave numbers (k{sub max} = 0.3). <span class="hlt">Big</span>BOSS will also place constraints on theories of modified gravity and inflation, and will measure the sum of neutrino masses to 0.024 eV accuracy.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/FR-2012-05-09/pdf/2012-11187.pdf','FEDREG'); return false;" href="https://www.gpo.gov/fdsys/pkg/FR-2012-05-09/pdf/2012-11187.pdf"><span id="translatedtitle">77 FR 27245 - <span class="hlt">Big</span> Stone National Wildlife Refuge, <span class="hlt">Big</span> Stone and Lac Qui Parle Counties, MN</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collection.action?collectionCode=FR">Federal Register 2010, 2011, 2012, 2013, 2014</a></p> <p></p> <p>2012-05-09</p> <p>... Fish and Wildlife Service <span class="hlt">Big</span> Stone National Wildlife Refuge, <span class="hlt">Big</span> Stone and Lac Qui Parle Counties, MN... comprehensive conservation plan (CCP) and environmental assessment (EA) for <span class="hlt">Big</span> Stone National Wildlife Refuge...: r3planning@fws.gov . Include ``<span class="hlt">Big</span> Stone Draft CCP/ EA'' in the subject line of the message. Fax:...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27559194','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27559194"><span id="translatedtitle"><span class="hlt">Big</span> Data: Implications for Health System Pharmacy.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stokes, Laura B; Rogers, Joseph W; Hertig, John B; Weber, Robert J</p> <p>2016-07-01</p> <p><span class="hlt">Big</span> Data refers to datasets that are so large and complex that traditional methods and hardware for collecting, sharing, and analyzing them are not possible. <span class="hlt">Big</span> Data that is accurate leads to more confident decision making, improved operational efficiency, and reduced costs. The rapid growth of health care information results in <span class="hlt">Big</span> Data around health services, treatments, and outcomes, and <span class="hlt">Big</span> Data can be used to analyze the benefit of health system pharmacy services. The goal of this article is to provide a perspective on how <span class="hlt">Big</span> Data can be applied to health system pharmacy. It will define <span class="hlt">Big</span> Data, describe the impact of <span class="hlt">Big</span> Data on population health, review specific implications of <span class="hlt">Big</span> Data in health system pharmacy, and describe an approach for pharmacy leaders to effectively use <span class="hlt">Big</span> Data. A few strategies involved in managing <span class="hlt">Big</span> Data in health system pharmacy include identifying potential opportunities for <span class="hlt">Big</span> Data, prioritizing those opportunities, protecting privacy concerns, promoting data transparency, and communicating outcomes. As health care information expands in its content and becomes more integrated, <span class="hlt">Big</span> Data can enhance the development of patient-centered pharmacy services. PMID:27559194</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4617656','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4617656"><span id="translatedtitle">A survey of <span class="hlt">big</span> data research</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Fang, Hua; Zhang, Zhaoyang; Wang, Chanpaul Jin; Daneshmand, Mahmoud; Wang, Chonggang; Wang, Honggang</p> <p>2015-01-01</p> <p><span class="hlt">Big</span> data create values for business and research, but pose significant challenges in terms of networking, storage, management, analytics and ethics. Multidisciplinary collaborations from engineers, computer scientists, statisticians and social scientists are needed to tackle, discover and understand <span class="hlt">big</span> data. This survey presents an overview of <span class="hlt">big</span> data initiatives, technologies and research in industries and academia, and discusses challenges and potential solutions. PMID:26504265</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=214222','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=214222"><span id="translatedtitle"><span class="hlt">Big</span> Sagebrush Seed Bank Densities Following Wildfires</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p><span class="hlt">Big</span> sagebrush (Artemisia sp.) is a critical shrub to such sagebrush obligate species as sage grouse, (Centocercus urophasianus), mule deer (Odocoileus hemionus), and pygmy rabbit (Brachylagus idahoensis). <span class="hlt">Big</span> sagebrush do not sprout after wildfires wildfires and <span class="hlt">big</span> sagebrush seed is generally sho...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=co-leadership&pg=5&id=ED065915','ERIC'); return false;" href="http://eric.ed.gov/?q=co-leadership&pg=5&id=ED065915"><span id="translatedtitle"><span class="hlt">Big</span> City Education: Its Challenge to Governance.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Haskew, Laurence D.</p> <p></p> <p>This chapter traces the migration from farms to cities and the later movement from cities to suburbs and discusses the impact of the resulting <span class="hlt">big</span> city environment on the governance of <span class="hlt">big</span> city education. The author (1) suggests how local, State, and Federal governments can improve <span class="hlt">big</span> city education; (2) discusses ways of planning for the future…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=IT&pg=6&id=EJ1104630','ERIC'); return false;" href="http://eric.ed.gov/?q=IT&pg=6&id=EJ1104630"><span id="translatedtitle">A SWOT Analysis of <span class="hlt">Big</span> Data</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Ahmadi, Mohammad; Dileepan, Parthasarati; Wheatley, Kathleen K.</p> <p>2016-01-01</p> <p>This is the decade of data analytics and <span class="hlt">big</span> data, but not everyone agrees with the definition of <span class="hlt">big</span> data. Some researchers see it as the future of data analysis, while others consider it as hype and foresee its demise in the near future. No matter how it is defined, <span class="hlt">big</span> data for the time being is having its glory moment. The most important…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=big&id=EJ1024478','ERIC'); return false;" href="http://eric.ed.gov/?q=big&id=EJ1024478"><span id="translatedtitle">Judging <span class="hlt">Big</span> Deals: Challenges, Outcomes, and Advice</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Glasser, Sarah</p> <p>2013-01-01</p> <p>This article reports the results of an analysis of five <span class="hlt">Big</span> Deal electronic journal packages to which Hofstra University's Axinn Library subscribes. COUNTER usage reports were used to judge the value of each <span class="hlt">Big</span> Deal. Limitations of usage statistics are also discussed. In the end, the author concludes that four of the five <span class="hlt">Big</span> Deals are good…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16080432','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16080432"><span id="translatedtitle">[Frequency quotient of paternity index Qf in a case of replacement of the natural father within a trio with his <span class="hlt">brother</span>].</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Berent, Jarosław; Jacewicz, Renata; Szram, Stefan</p> <p>2005-01-01</p> <p>Cases of trios in which the natural father's near blood-relative instead of the natural father are among the hardest to give an expert opinion on. The goal of this study was to determine with what frequencies specific given values of paternity index appear in trios with the natural father and with the natural father's <span class="hlt">brother</span>, and whether these frequencies can be the basis for discovering the substitution of the natural father by a <span class="hlt">brother</span> in a given trio examined. The study material was the population of genotypes investigated in the AmpF/STR SGM Plus system. It was seen that the higher the paternity index values, the more frequently they appear in trios with the natural father, and less frequently in trios with the natural father's <span class="hlt">brother</span>. This dependency has a general character and obtained in all the systems studied. The frequency quotients Qf (defined as the frequency of a given PI value in trios with the natural father in relation to the "reduced" frequency of the PI value in trios with the <span class="hlt">brother</span> of the natural father) are found in the region of c. 0.6 to c. 1.4, whereby extreme values are rare, and the most frequent are cases where Qf oscillates within modest limits around the value 1. This fact shows that the majority of cases, calculated Qf values contribute little to resolving the question of whether the defendant--or his <span class="hlt">brother</span>--is the child's father. PMID:16080432</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/1011906','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/1011906"><span id="translatedtitle"><span class="hlt">Big</span> Bang Day : The Great <span class="hlt">Big</span> Particle Adventure - 3. Origins</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p></p> <p>2009-10-13</p> <p>In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. If the LHC is successful, it will explain the nature of the Universe around us in terms of a few simple ingredients and a few simple rules. But the Universe now was forged in a <span class="hlt">Big</span> Bang where conditions were very different, and the rules were very different, and those early moments were crucial to determining how things turned out later. At the LHC they can recreate conditions as they were billionths of a second after the <span class="hlt">Big</span> Bang, before atoms and nuclei existed. They can find out why matter and antimatter didn't mutually annihilate each other to leave behind a Universe of pure, brilliant light. And they can look into the very structure of space and time - the fabric of the Universe</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21027864','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21027864"><span id="translatedtitle">Solution of a braneworld <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang cosmology</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>McFadden, Paul L.; Turok, Neil; Steinhardt, Paul J.</p> <p>2007-11-15</p> <p>We solve for the cosmological perturbations in a five-dimensional background consisting of two separating or colliding boundary branes, as an expansion in the collision speed V divided by the speed of light c. Our solution permits a detailed check of the validity of four-dimensional effective theory in the vicinity of the event corresponding to the <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang singularity. We show that the four-dimensional description fails at the first nontrivial order in (V/c){sup 2}. At this order, there is nontrivial mixing of the two relevant four-dimensional perturbation modes (the growing and decaying modes) as the boundary branes move from the narrowly separated limit described by Kaluza-Klein theory to the well-separated limit where gravity is confined to the positive-tension brane. We comment on the cosmological significance of the result and compute other quantities of interest in five-dimensional cosmological scenarios.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2012PhLB..715..278B','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2012PhLB..715..278B"><span id="translatedtitle">Antigravity and the <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang transition</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Bars, Itzhak; Chen, Shih-Hung; Steinhardt, Paul J.; Turok, Neil</p> <p>2012-08-01</p> <p>We point out a new phenomenon which seems to be generic in 4d effective theories of scalar fields coupled to Einstein gravity, when applied to cosmology. A lift of such theories to a Weyl-invariant extension allows one to define classical evolution through cosmological singularities unambiguously, and hence construct geodesically complete background spacetimes. An attractor mechanism ensures that, at the level of the effective theory, generic solutions undergo a <span class="hlt">big</span> crunch/<span class="hlt">big</span> bang transition by contracting to zero size, passing through a brief antigravity phase, shrinking to zero size again, and re-emerging into an expanding normal gravity phase. The result may be useful for the construction of complete bouncing cosmologies like the cyclic model.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/sciencecinema/biblio/1011906','SCIGOVIMAGE-SCICINEMA'); return false;" href="http://www.osti.gov/sciencecinema/biblio/1011906"><span id="translatedtitle"><span class="hlt">Big</span> Bang Day : The Great <span class="hlt">Big</span> Particle Adventure - 3. Origins</span></a></p> <p><a target="_blank" href="http://www.osti.gov/sciencecinema/">ScienceCinema</a></p> <p>None</p> <p>2011-04-25</p> <p>In this series, comedian and physicist Ben Miller asks the CERN scientists what they hope to find. If the LHC is successful, it will explain the nature of the Universe around us in terms of a few simple ingredients and a few simple rules. But the Universe now was forged in a <span class="hlt">Big</span> Bang where conditions were very different, and the rules were very different, and those early moments were crucial to determining how things turned out later. At the LHC they can recreate conditions as they were billionths of a second after the <span class="hlt">Big</span> Bang, before atoms and nuclei existed. They can find out why matter and antimatter didn't mutually annihilate each other to leave behind a Universe of pure, brilliant light. And they can look into the very structure of space and time - the fabric of the Universe</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16309949','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16309949"><span id="translatedtitle">Evaluation of genotoxic effects of Apitol (cymiazole hydrochloride) in vitro by measurement of <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Stanimirovic, Zoran; Stevanovic, Jevrosima; Jovanovic, Slobodan; Andjelkovic, Marko</p> <p>2005-12-30</p> <p>Apitol, with cymiazole hydrochloride as the active ingredient, is used in bee-keeping against the ectoparasitic mite Varroa destructor. The preparation was evaluated for genotoxicity in cultured human peripheral blood lymphocytes. <span class="hlt">Sister</span> chromatid exchange, the mitotic index and the cell proliferation index were determined for three experimental concentrations of Apitol (0.001, 0.01 and 0.1 mg/ml). All concentrations significantly (p < 0.001) increased the mitotic index (MI = 7.35+/-0.18%, 8.31+/-0.20% and 12.33+/-0.25%, respectively), the proliferative index (PI = 1.83+/-0.01, 1.84+/-0.01 and 1.88+/-0.02, respectively) and the frequency of <span class="hlt">sister</span> chromatid exchange (SCE = 8.19+/-1.81, 8.78+/-1.80 and 13.46+/-1.88, respectively), suggesting that cymiazole hydrochloride has genotoxic potential. PMID:16309949</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/19041959','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/19041959"><span id="translatedtitle">Very early premature ovarian failure in two <span class="hlt">sisters</span> compound heterozygous for the FMR1 premutation.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Van Esch, Hilde; Buekenhout, Luc; Race, Valerie; Matthijs, Gert</p> <p>2009-01-01</p> <p>Expansion of the CGG trinucleotide repeat in the 5' untranslated region of the fragile X mental retardation 1 (FMR1) gene within the premutation range is one of the known genetic factors associated with premature ovarian failure and earlier age at menopause. Studies have shown that approximately 16-26% of female carriers will develop premature ovarian failure, and current research is focussed on the identification of molecular factors that predict its occurrence in female carriers. In this report we present two <span class="hlt">sisters</span> who are compound heterozygous for a premutation, and who were referred because of very early menopause, occurring at the age of 17 years in the youngest <span class="hlt">sister</span>. Premature ovarian failure associated with FMR1 premutation at such an early age has not been reported in the literature before. PMID:19041959</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22937155','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22937155"><span id="translatedtitle">The first record of a trans-oceanic <span class="hlt">sister</span>-group relationship between obligate vertebrate troglobites.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Chakrabarty, Prosanta; Davis, Matthew P; Sparks, John S</p> <p>2012-01-01</p> <p>We show using the most complete phylogeny of one of the most species-rich orders of vertebrates (Gobiiformes), and calibrations from the rich fossil record of teleost fishes, that the genus Typhleotris, endemic to subterranean karst habitats in southwestern Madagascar, is the <span class="hlt">sister</span> group to Milyeringa, endemic to similar subterranean systems in northwestern Australia. Both groups are eyeless, and our phylogenetic and biogeographic results show that these obligate cave fishes now found on opposite ends of the Indian Ocean (separated by nearly 7,000 km) are each others closest relatives and owe their origins to the break up of the southern supercontinent, Gondwana, at the end of the Cretaceous period. Trans-oceanic <span class="hlt">sister</span>-group relationships are otherwise unknown between blind, cave-adapted vertebrates and our results provide an extraordinary case of Gondwanan vicariance. PMID:22937155</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li class="active"><span>23</span></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_23 --> <div id="page_24" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="461"> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/6885703','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/6885703"><span id="translatedtitle"><span class="hlt">Sister</span> chromatid exchange analysis to monitor genotoxic chemicals. (Latest citations from Pollution Abstracts). Published Search</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Not Available</p> <p>1993-03-01</p> <p>The bibliography contains citations concerning the use of the <span class="hlt">sister</span> chromatid exchange (SCE) analysis for toxicological studies. SCE analysis are very sensitive measures of genotoxic damage to chromosomes. SCE toxicological studies analyzing ionizing radiation, chromium compounds, styrene, paint thinner, mercury, cigarette smoke, coal dust, fuel oil, insecticides, ethylene oxide, diesel exhaust, and polychlorinated biphenyls are discussed. SCE studies using both human and animal tissue cultures are described. (Contains a minimum of 191 citations and includes a subject term index and title list.)</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2670183','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2670183"><span id="translatedtitle">Characterization of the components of the putative mammalian <span class="hlt">sister</span> chromatid cohesion complex</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Darwiche, N.; Freeman, L.A.; Strunnikov, A.</p> <p>2009-01-01</p> <p>Establishing and maintaining proper <span class="hlt">sister</span> chromatid cohesion throughout the cell cycle are essential for maintaining genome integrity. To understand how <span class="hlt">sister</span> chromatid cohesion occurs in mammals, we have cloned and characterized mouse orthologs of proteins known to be involved in <span class="hlt">sister</span> chromatid cohesion in other organisms. The cDNAs for the mouse orthologs of SMC1S.c. and SMC3S.c., mSMCB and mSMCD respectively, were cloned and the corresponding transcripts and proteins were characterized. mSMCB and mSMCD are transcribed at similar levels in adult mouse tissues except in testis, which has an excess of mSMCD transcripts. The mSMCB and mSMCD proteins, as well as the PW29 protein, a mouse homolog of Mcd1pS.c./Rad21S.p., form a complex similar to cohesin in X. laevis. mSMCB, mSMCD and PW29 protein levels show no significant cell-cycle dependence. The bulk of the mSMCB, mSMCD and PW29 proteins undergo redistribution from the chromosome vicinity to the cytoplasm during prometaphase and back to the chromatin in telophase. This pattern of intracellular localization suggests a complex role for this group of SMC proteins in chromosome dynamics. The PW29 protein and PCNA, which have both been implicated in <span class="hlt">sister</span> chromatid cohesion, do not colocalize, indicating that these proteins may not function in the same cohesion pathway. Overexpression of a PW29-GFP fusion protein in mouse fibroblasts leads to inhibition of proliferation, implicating this protein and its complex with SMC proteins in the control of mitotic cycle progression. PMID:10375619</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/15451707','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/15451707"><span id="translatedtitle">The queer sensitive interveners in the Little <span class="hlt">Sisters</span> case: a response to Dr. Kendall.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Busby, Karen</p> <p>2004-01-01</p> <p>Three queer sensitive organizations intervened before the Supreme Court of Canada in Little <span class="hlt">Sisters</span> v. Canada, a case that challenged whether and how Canada Customs treated cross border shipments to a gay and lesbian bookstore. This paper reviews the queer sensitive organizations' arguments on some of the issues in the case, especially the scope of obscenity law, and challenges misconceptions about their positions, including those presented in Dr. Kendall's paper (appearing in this volume). PMID:15451707</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287083','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287083"><span id="translatedtitle"><span class="hlt">Big</span> Data in Medicine is Driving <span class="hlt">Big</span> Changes</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Verspoor, K.</p> <p>2014-01-01</p> <p>Summary Objectives To summarise current research that takes advantage of “<span class="hlt">Big</span> Data” in health and biomedical informatics applications. Methods Survey of trends in this work, and exploration of literature describing how large-scale structured and unstructured data sources are being used to support applications from clinical decision making and health policy, to drug design and pharmacovigilance, and further to systems biology and genetics. Results The survey highlights ongoing development of powerful new methods for turning that large-scale, and often complex, data into information that provides new insights into human health, in a range of different areas. Consideration of this body of work identifies several important paradigm shifts that are facilitated by <span class="hlt">Big</span> Data resources and methods: in clinical and translational research, from hypothesis-driven research to data-driven research, and in medicine, from evidence-based practice to practice-based evidence. Conclusions The increasing scale and availability of large quantities of health data require strategies for data management, data linkage, and data integration beyond the limits of many existing information systems, and substantial effort is underway to meet those needs. As our ability to make sense of that data improves, the value of the data will continue to increase. Health systems, genetics and genomics, population and public health; all areas of biomedicine stand to benefit from <span class="hlt">Big</span> Data and the associated technologies. PMID:25123716</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4755749"><span id="translatedtitle"><span class="hlt">Sister</span> kinetochore splitting and precocious disintegration of bivalents could explain the maternal age effect</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Zielinska, Agata P; Holubcova, Zuzana; Blayney, Martyn; Elder, Kay; Schuh, Melina</p> <p>2015-01-01</p> <p>Aneuploidy in human eggs is the leading cause of pregnancy loss and Down’s syndrome. Aneuploid eggs result from chromosome segregation errors when an egg develops from a progenitor cell, called an oocyte. The mechanisms that lead to an increase in aneuploidy with advanced maternal age are largely unclear. Here, we show that many <span class="hlt">sister</span> kinetochores in human oocytes are separated and do not behave as a single functional unit during the first meiotic division. Having separated <span class="hlt">sister</span> kinetochores allowed bivalents to rotate by 90 degrees on the spindle and increased the risk of merotelic kinetochore-microtubule attachments. Advanced maternal age led to an increase in <span class="hlt">sister</span> kinetochore separation, rotated bivalents and merotelic attachments. Chromosome arm cohesion was weakened, and the fraction of bivalents that precociously dissociated into univalents was increased. Together, our data reveal multiple age-related changes in chromosome architecture that could explain why oocyte aneuploidy increases with advanced maternal age. DOI: http://dx.doi.org/10.7554/eLife.11389.001 PMID:26670547</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/26844660','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/26844660"><span id="translatedtitle"><span class="hlt">Big</span> data and ophthalmic research.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Clark, Antony; Ng, Jonathon Q; Morlet, Nigel; Semmens, James B</p> <p>2016-01-01</p> <p>Large population-based health administrative databases, clinical registries, and data linkage systems are a rapidly expanding resource for health research. Ophthalmic research has benefited from the use of these databases in expanding the breadth of knowledge in areas such as disease surveillance, disease etiology, health services utilization, and health outcomes. Furthermore, the quantity of data available for research has increased exponentially in recent times, particularly as e-health initiatives come online in health systems across the globe. We review some <span class="hlt">big</span> data concepts, the databases and data linkage systems used in eye research-including their advantages and limitations, the types of studies previously undertaken, and the future direction for <span class="hlt">big</span> data in eye research. PMID:26844660</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=77065503&CFTOKEN=74361355','EPA-EIMS'); return false;" href="http://cfpub.epa.gov/si/si_public_record_report.cfm?dirEntryId=39928&keyword=infusion&actType=&TIMSType=+&TIMSSubTypeID=&DEID=&epaNumber=&ntisID=&archiveStatus=Both&ombCat=Any&dateBeginCreated=&dateEndCreated=&dateBeginPublishedPresented=&dateEndPublishedPresented=&dateBeginUpdated=&dateEndUpdated=&dateBeginCompleted=&dateEndCompleted=&personID=&role=Any&journalID=&publisherID=&sortBy=revisionDate&count=50&CFID=77065503&CFTOKEN=74361355"><span id="translatedtitle">INDUCTION, ACCUMULATION, AND PERSISTENCE OF <span class="hlt">SISTER</span> CHROMATID EXCHANGES IN WOMEN WITH BREAST CANCER RECEIVING CYCLOPHOSPHAMIDE, ANDRIAMYCIN, AND 5-FLUOROACIL CHEMOTHERAPY</span></a></p> <p><a target="_blank" href="http://oaspub.epa.gov/eims/query.page">EPA Science Inventory</a></p> <p></p> <p></p> <p>The induction, stimulation, and persistence of <span class="hlt">sister</span> chromatid exchanges (SCE's) and high SCE frequency cells (HFC's) was measured in peripheral lymphocytes of women with breast cancer before chemotherapy and on multiple occasions during and after therapy. Chemotherapy consisted...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=clock&pg=3&id=EJ1008532','ERIC'); return false;" href="http://eric.ed.gov/?q=clock&pg=3&id=EJ1008532"><span id="translatedtitle">District Bets <span class="hlt">Big</span> on Standards</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Gewertz, Catherine</p> <p>2013-01-01</p> <p>The <span class="hlt">big</span> clock in Dowan McNair-Lee's 8th grade classroom in the Stuart-Hobson Middle School is silent, but she can hear the minutes ticking away nonetheless. On this day, like any other, the clock is a constant reminder of how little time she has to prepare her students--for spring tests, and for high school and all that lies beyond it. The…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2441944','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2441944"><span id="translatedtitle">S-Adenosylhomocysteine hydrolase deficiency: A second patient, the younger <span class="hlt">brother</span> of the index patient, and outcomes during therapy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Barić, I.; Ćuk, M.; Fumić, K.; Vugrek, O.; Allen, R. H.; Glenn, B.; Maradin, M.; Pažanin, L.; Pogribny, I.; Radoš, M.; Sarnavka, V.; Schulze, A.; Stabler, S.; Wagner, C.; Zeisel, S. H.; Mudd, S. H.</p> <p>2008-01-01</p> <p>Summary S-Adenosylhomocysteine (AdoHcy) hydrolase deficiency has been proven in a human only once, in a recently described Croatian boy. Here we report the clinical course and biochemical abnormalities of the younger <span class="hlt">brother</span> of this proband. This younger <span class="hlt">brother</span> has the same two mutations in the gene encoding AdoHcy hydrolase, and has been monitored since birth. We report, as well, outcomes during therapy for both patients. The information obtained suggests that the disease starts in utero and is characterized primarily by neuromuscular symptomatology (hypotonia, sluggishness, psychomotor delay, absent tendon reflexes, delayed myelination). The laboratory abnormalities are markedly increased creatine kinase and elevated aminotransferases, as well as specific amino acid aberrations that pinpoint the aetiology. The latter include, most importantly, markedly elevated plasma AdoHcy. Plasma S-adenosylmethionine (AdoMet) is also elevated, as is methionine (although the hypermethioninaemia may be absent or nonsignificant in the first weeks of life). The disease seems to be at least to some extent treatable, as shown by improved myelination and psychomotor development during dietary methionine restriction and supplementation with creatine and phosphatidylcholine. PMID:16435181</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/22147254','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/22147254"><span id="translatedtitle">Two <span class="hlt">brothers</span> with skewed thiopurine metabolism in ulcerative colitis treated successfully with allopurinol and mercaptopurine dose reduction.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hoentjen, Frank; Hanauer, Stephen B; de Boer, Nanne K; Rubin, David T</p> <p>2012-01-01</p> <p>Thiopurine therapy effectively maintains remission in inflammatory bowel disease. However, many patients are unable to achieve optimum benefits from azathioprine or 6-mercaptopurine because of undesirable metabolism related to high thiopurine methyltransferase (TPMT) activity characterized by hepatic transaminitis secondary to increased 6-methylmercaptopurine (6-MMP) production and reduced levels of therapeutic 6-thioguanine nucleotide (6-TGN). Allopurinol can optimize this skewed metabolism. We discuss two <span class="hlt">brothers</span> who were both diagnosed with ulcerative colitis (UC). Their disease remained active despite oral and topical mesalamines. Steroids followed by 6-mercaptopurine (MP) were unsuccessfully introduced for both patients and both were found to have high 6-MMP and low 6-TGN levels, despite normal TMPT enzyme activity, accompanied by transaminitis. Allopurinol was introduced in combination with MP dose reduction. For both <span class="hlt">brothers</span> addition of allopurinol was associated with successful remission and optimized MP metabolites. These siblings with active UC illustrate that skewed thiopurine metabolism may occur despite normal TPMT enzyme activity and can lead to adverse events in the absence of disease control. We confirm previous data showing that addition of allopurinol can reverse this skewed metabolism, and reduce both hepatotoxicity and disease activity, but we now also introduce the concept of a family history of preferential MP metabolism as a clue to effective management for other family members. PMID:22147254</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2001gbb..book.....A&link_type=ABSTRACT','NASAADS'); return false;" href="http://adsabs.harvard.edu/cgi-bin/nph-data_query?bibcode=2001gbb..book.....A&link_type=ABSTRACT"><span id="translatedtitle">Genesis of the <span class="hlt">big</span> bang</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Alpher, Ralph A.; Herman, Robert</p> <p></p> <p>The authors of this volume have been intimately connected with the conception of the <span class="hlt">big</span> bang model since 1947. Following the late George Gamov's ideas in 1942 and more particularly in 1946 that the early universe was an appropriate site for the synthesis of the elements, they became deeply involved in the question of cosmic nucleosynthesis and particularly the synthesis of the light elements. In the course of this work they developed a general relativistic model of the expanding universe with physics folded in, which led in a progressive, logical sequence to our prediction of the existence of a present cosmic background radiation some seventeen years before the observation of such radiation was reported by Penzias and Wilson. In addition, they carried out with James W. Follin, Jr., a detailed study of the physics of what was then considered to be the very early universe, starting a few seconds after the <span class="hlt">big</span> bang, which still provides a methodology for studies of light element nucleosynthesis. Because of their involvement, they bring a personal perspective to the subject. They present a picture of what is now believed to be the state of knowledge about the evolution of the expanding universe and delineate the story of the development of the <span class="hlt">big</span> bang model as they have seen and lived it from their own unique vantage point.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23074865','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23074865"><span id="translatedtitle"><span class="hlt">Big</span> data: the management revolution.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>McAfee, Andrew; Brynjolfsson, Erik</p> <p>2012-10-01</p> <p><span class="hlt">Big</span> data, the authors write, is far more powerful than the analytics of the past. Executives can measure and therefore manage more precisely than ever before. They can make better predictions and smarter decisions. They can target more-effective interventions in areas that so far have been dominated by gut and intuition rather than by data and rigor. The differences between <span class="hlt">big</span> data and analytics are a matter of volume, velocity, and variety: More data now cross the internet every second than were stored in the entire internet 20 years ago. Nearly real-time information makes it possible for a company to be much more agile than its competitors. And that information can come from social networks, images, sensors, the web, or other unstructured sources. The managerial challenges, however, are very real. Senior decision makers have to learn to ask the right questions and embrace evidence-based decision making. Organizations must hire scientists who can find patterns in very large data sets and translate them into useful business information. IT departments have to work hard to integrate all the relevant internal and external sources of data. The authors offer two success stories to illustrate how companies are using <span class="hlt">big</span> data: PASSUR Aerospace enables airlines to match their actual and estimated arrival times. Sears Holdings directly analyzes its incoming store data to make promotions much more precise and faster. PMID:23074865</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287080','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4287080"><span id="translatedtitle">EHR <span class="hlt">Big</span> Data Deep Phenotyping</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Lenert, L.; Lopez-Campos, G.</p> <p>2014-01-01</p> <p>Summary Objectives Given the quickening speed of discovery of variant disease drivers from combined patient genotype and phenotype data, the objective is to provide methodology using <span class="hlt">big</span> data technology to support the definition of deep phenotypes in medical records. Methods As the vast stores of genomic information increase with next generation sequencing, the importance of deep phenotyping increases. The growth of genomic data and adoption of Electronic Health Records (EHR) in medicine provides a unique opportunity to integrate phenotype and genotype data into medical records. The method by which collections of clinical findings and other health related data are leveraged to form meaningful phenotypes is an active area of research. Longitudinal data stored in EHRs provide a wealth of information that can be used to construct phenotypes of patients. We focus on a practical problem around data integration for deep phenotype identification within EHR data. The use of <span class="hlt">big</span> data approaches are described that enable scalable markup of EHR events that can be used for semantic and temporal similarity analysis to support the identification of phenotype and genotype relationships. Conclusions Stead and colleagues’ 2005 concept of using light standards to increase the productivity of software systems by riding on the wave of hardware/processing power is described as a harbinger for designing future healthcare systems. The <span class="hlt">big</span> data solution, using flexible markup, provides a route to improved utilization of processing power for organizing patient records in genotype and phenotype research. PMID:25123744</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2004AGUFM.T33A1327T','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2004AGUFM.T33A1327T"><span id="translatedtitle">Finite strain and relative rheology from field exposures of mantle peridotite, Twin <span class="hlt">Sisters</span>, Washington</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Tikoff, B.; Larson, C. E.; Newman, J.; Little, T.</p> <p>2004-12-01</p> <p>We present estimates of finite strain and relative rheology of naturally deformed mantle materials based on field observations in the Twin <span class="hlt">Sisters</span> Range of Washington state. The Twin <span class="hlt">Sisters</span> ultramafic body is a 16 by 5.5 km body located 30 km east of Bellingham, Washington. The outcrops show virtually no serpentinization away from the metamorphic sole. We conducted detailed structural mapping in a 100 by 150 meter field area located east of the crest of the Twin <span class="hlt">Sisters</span> range and approximately midway between the north and south ends. The foliation strikes ~155 and the lineation pitches 40 S. Folded orthopyroxenite dikes within the host dunite allow us to characterize the finite strain. Dikes trending NE-SE were folded, while dikes trending NW-SE were elongated or boudinaged. Using the method of Talbot (1970), the principal stretch directions in the horizontal plane were calculated using the deformed dikes. We calculated a maximum stretch of 1.596 oriented at 151 (similar to the trace of the foliation) and a minimum stretch of 0.286 in direction 061. Assuming that the lineation and foliation represent the orientation of S1 and the S1S2 plane, respectively, a finite strain ellipsoid was determined. The best fitting answer defines an oblate ellipsoid with S1=3.15, S2=1.11, and S3=0.286. Thus, on this outcrop, the Twin <span class="hlt">Sisters</span> dunite has an oblate-shaped finite strain ellipsoid whose long axis plunges 40 to the SE. The same area provides constraints on relative rheology. Folded orthopyroxenite dikes show a linear relationship between fold wavelength and dike thickness, indicating that they initiated as buckle folds. Using dynamic instability analysis, the orthopyroxene within the dikes is calculated to have ~31 times the effective viscosity of olivine of the dunite matrix, assuming a power law exponenent of n=3 (dislocation creep) for both the dikes and the matrix. Although not investigated in detail, similar orientations of fabrics are observed throughout the Twin</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/23613454','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/23613454"><span id="translatedtitle">Palmo-Plantar hyperkeratosis, intellectual disability, and spastic paraplegia in two maternal half <span class="hlt">brothers</span>: further evidence for an X-linked inheritance.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Isidor, Bertrand; Lefebvre, Tiphaine; Barbarot, Sébastien; Perrier, Julie; Mercier, Sandra; Péréon, Yann; Le Caignec, Cédric; David, Albert</p> <p>2013-06-01</p> <p>In 1983, Fitzsimmons et al. reported four <span class="hlt">brothers</span> with an unrecognized disorder characterized by intellectual disability, spastic paraplegia, and palmo-plantar hyperkeratosis (OMIM 309500). In this report, we describe a family in which two males, maternal half-<span class="hlt">brothers</span>, had learning disabilities. Both patients also showed spasticity in the lower limbs and palmo-plantar hyperkeratosis. The mother of the affected boys had learning difficulties but did not show any dermatological symptoms. This report confirms that the association of features reported by Fitzsimmons et al. is a distinct entity and further suggests an X-linked mode of inheritance. PMID:23613454</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1470669"><span id="translatedtitle">Chl1p, a DNA helicase-like protein in budding yeast, functions in <span class="hlt">sister</span>-chromatid cohesion.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Skibbens, Robert V</p> <p>2004-01-01</p> <p>From the time of DNA replication until anaphase onset, <span class="hlt">sister</span> chromatids remain tightly paired along their length. Ctf7p/Eco1p is essential to establish <span class="hlt">sister</span>-chromatid pairing during S-phase and associates with DNA replication components. DNA helicases precede the DNA replication fork and thus will first encounter chromatin sites destined for cohesion. In this study, I provide the first evidence that a DNA helicase is required for proper <span class="hlt">sister</span>-chromatid cohesion. Characterizations of chl1 mutant cells reveal that CHL1 interacts genetically with both CTF7/ECO1 and CTF18/CHL12, two genes that function in <span class="hlt">sister</span>-chromatid cohesion. Consistent with genetic interactions, Chl1p physically associates with Ctf7p/Eco1p both in vivo and in vitro. Finally, a functional assay reveals that Chl1p is critical for <span class="hlt">sister</span>-chromatid cohesion. Within the budding yeast genome, Chl1p exhibits the highest degree of sequence similarity to human CHL1 isoforms and BACH1. Previous studies revealed that human CHLR1 exhibits DNA helicase-like activities and that BACH1 is a helicase-like protein that associates with the tumor suppressor BRCA1 to maintain genome integrity. Our findings document a novel role for Chl1p in <span class="hlt">sister</span>-chromatid cohesion and provide new insights into the possible mechanisms through which DNA helicases may contribute to cancer progression when mutated. PMID:15020404</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/21308618','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/21308618"><span id="translatedtitle">Turning <span class="hlt">big</span> bang into <span class="hlt">big</span> bounce. I. Classical dynamics</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Dzierzak, Piotr; Malkiewicz, Przemyslaw; Piechocki, Wlodzimierz</p> <p>2009-11-15</p> <p>The <span class="hlt">big</span> bounce (BB) transition within a flat Friedmann-Robertson-Walker model is analyzed in the setting of loop geometry underlying the loop cosmology. We solve the constraint of the theory at the classical level to identify physical phase space and find the Lie algebra of the Dirac observables. We express energy density of matter and geometrical functions in terms of the observables. It is the modification of classical theory by the loop geometry that is responsible for BB. The classical energy scale specific to BB depends on a parameter that should be fixed either by cosmological data or determined theoretically at quantum level, otherwise the energy scale stays unknown.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=mesa&pg=6&id=EJ566437','ERIC'); return false;" href="http://eric.ed.gov/?q=mesa&pg=6&id=EJ566437"><span id="translatedtitle">Powerful <span class="hlt">Sisters</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Chenoweth, Karin; Stephens, Angela; Evelyn, Jamilah</p> <p>1998-01-01</p> <p>Five black women presiding over college campuses with over 20,000 students are profiled: Del M. Anderson (City College of San Francisco, CA); Constance M. Carroll (San Diego Mesa College, CA); Ruth Burgos-Sasscer (Houston Community College System, TX); Jerry Sue Thornton (Cuyahoga Community College, OH); and Belle S. Wheelan (Northern Virginia…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2013-title12-vol4/pdf/CFR-2013-title12-vol4-sec238-31.pdf','CFR2013'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2013-title12-vol4/pdf/CFR-2013-title12-vol4-sec238-31.pdf"><span id="translatedtitle">12 CFR 238.31 - Transactions requiring prior notice.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2013&page.go=Go">Code of Federal Regulations, 2013 CFR</a></p> <p></p> <p>2013-01-01</p> <p>..., stepmother, <span class="hlt">brother</span>, <span class="hlt">sister</span>, stepbrother, stepsister, son, daughter, stepson, stepdaughter, grandparent, grandson, granddaughter, father-in-law, mother-in-law, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>-in-law, son-in-law,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec633-320.pdf','CFR2011'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2011-title20-vol3/pdf/CFR-2011-title20-vol3-sec633-320.pdf"><span id="translatedtitle">20 CFR 633.320 - Nepotism.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2011&page.go=Go">Code of Federal Regulations, 2011 CFR</a></p> <p></p> <p>2011-04-01</p> <p>... family” means wife, husband, son, daughter, mother, father, <span class="hlt">brother</span>, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>, <span class="hlt">sister</span>-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew,...</p> </li> </ol> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li class="active"><span>24</span></li> <li><a href="#" onclick='return showDiv("page_25");'>25</a></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div><!-- col-sm-12 --> </div><!-- row --> </div><!-- page_24 --> <div id="page_25" class="hiddenDiv"> <div class="row"> <div class="col-sm-12"> <div class="pull-right"> <ul class="pagination"> <li><a href="#" onclick='return showDiv("page_1");'>«</a></li> <li><a href="#" onclick='return showDiv("page_21");'>21</a></li> <li><a href="#" onclick='return showDiv("page_22");'>22</a></li> <li><a href="#" onclick='return showDiv("page_23");'>23</a></li> <li><a href="#" onclick='return showDiv("page_24");'>24</a></li> <li class="active"><span>25</span></li> <li><a href="#" onclick='return showDiv("page_25");'>»</a></li> </ul> </div> </div> </div> <div class="row"> <div class="col-sm-12"> <ol class="result-class" start="481"> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec633-320.pdf','CFR'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2010-title20-vol3/pdf/CFR-2010-title20-vol3-sec633-320.pdf"><span id="translatedtitle">20 CFR 633.320 - Nepotism.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2010&page.go=Go">Code of Federal Regulations, 2010 CFR</a></p> <p></p> <p>2010-04-01</p> <p>... family” means wife, husband, son, daughter, mother, father, <span class="hlt">brother</span>, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>, <span class="hlt">sister</span>-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol3/pdf/CFR-2012-title20-vol3-sec633-320.pdf','CFR2012'); return false;" href="https://www.gpo.gov/fdsys/pkg/CFR-2012-title20-vol3/pdf/CFR-2012-title20-vol3-sec633-320.pdf"><span id="translatedtitle">20 CFR 633.320 - Nepotism.</span></a></p> <p><a target="_blank" href="http://www.gpo.gov/fdsys/browse/collectionCfr.action?selectedYearFrom=2012&page.go=Go">Code of Federal Regulations, 2012 CFR</a></p> <p></p> <p>2012-04-01</p> <p>... family” means wife, husband, son, daughter, mother, father, <span class="hlt">brother</span>, <span class="hlt">brother</span>-in-law, <span class="hlt">sister</span>, <span class="hlt">sister</span>-in-law, son-in-law, daughter-in-law, mother-in-law, father-in-law, aunt, uncle, niece, nephew,...</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=cafe&id=EJ984125','ERIC'); return false;" href="http://eric.ed.gov/?q=cafe&id=EJ984125"><span id="translatedtitle"><span class="hlt">Big</span> Ideas behind Daily 5 and CAFE</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Boushey, Gail; Moser, Joan</p> <p>2012-01-01</p> <p>The Daily 5 and CAFE were born out of The <span class="hlt">Sister</span>'s research and observations of instructional mentors, their intense desire to be able to deliver highly intentional, focused instruction to small groups and individuals while the rest of the class was engaged in truly authentic reading and writing, and their understanding that a one size fits all…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/servlets/purl/1014086','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/servlets/purl/1014086"><span id="translatedtitle"><span class="hlt">Big</span> Machines and <span class="hlt">Big</span> Science: 80 Years of Accelerators at Stanford</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Loew, Gregory</p> <p>2008-12-16</p> <p>Longtime SLAC physicist Greg Loew will present a trip through SLAC's origins, highlighting its scientific achievements, and provide a glimpse of the lab's future in '<span class="hlt">Big</span> Machines and <span class="hlt">Big</span> Science: 80 Years of Accelerators at Stanford.'</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=250232','TEKTRAN'); return false;" href="http://www.ars.usda.gov/research/publications/Publications.htm?seq_no_115=250232"><span id="translatedtitle">Native perennial forb variation between mountain <span class="hlt">big</span> sagebrush and Wyoming <span class="hlt">big</span> sagebrush plant communities</span></a></p> <p><a target="_blank" href="http://www.ars.usda.gov/services/TekTran.htm">Technology Transfer Automated Retrieval System (TEKTRAN)</a></p> <p></p> <p></p> <p><span class="hlt">Big</span> sagebrush (Artemisia tridentata Nutt.) occupies large portions of the western United States and provides valuable wildlife habitat. However, information is lacking quantifying differences in native perennial forb characteristics between mountain <span class="hlt">big</span> sagebrush (A. tridentata spp. vaseyana (Rydb....</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=monitor+AND+Media&pg=7&id=EJ615224','ERIC'); return false;" href="http://eric.ed.gov/?q=monitor+AND+Media&pg=7&id=EJ615224"><span id="translatedtitle"><span class="hlt">Big</span>.</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Everhart, Nancy; Everhart, Harry</p> <p>2000-01-01</p> <p>Presents information on the different types of data projectors, to help librarians make a smart selection for their library. Describes multimedia projectors; document cameras; large-screen televisions, monitors, and flat panels; electronic whiteboards, and identifies uses, manufacturers, and prices. Notes three important ways that data projectors…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22218288','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22218288"><span id="translatedtitle"><span class="hlt">Big</span> bang nucleosynthesis: An update</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Olive, Keith A.</p> <p>2013-07-23</p> <p>An update on the standard model of <span class="hlt">big</span> bang nucleosynthesis (BBN) is presented. With the value of the baryon-tophoton ratio determined to high precision by WMAP, standard BBN is a parameter-free theory. In this context, the theoretical prediction for the abundances of D, {sup 4}He, and {sup 7}Li is discussed and compared to their observational determination. While concordance for D and {sup 4}He is satisfactory, the prediction for {sup 7}Li exceeds the observational determination by a factor of about four. Possible solutions to this problem are discussed.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27480375','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27480375"><span id="translatedtitle">Fitting ERGMs on <span class="hlt">big</span> networks.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>An, Weihua</p> <p>2016-09-01</p> <p>The exponential random graph model (ERGM) has become a valuable tool for modeling social networks. In particular, ERGM provides great flexibility to account for both covariates effects on tie formations and endogenous network formation processes. However, there are both conceptual and computational issues for fitting ERGMs on <span class="hlt">big</span> networks. This paper describes a framework and a series of methods (based on existent algorithms) to address these issues. It also outlines the advantages and disadvantages of the methods and the conditions to which they are most applicable. Selected methods are illustrated through examples. PMID:27480375</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/1997PhyEs..10..370M','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/1997PhyEs..10..370M"><span id="translatedtitle"><span class="hlt">Big</span> bang theory under fire.</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Mitchell, W. C.</p> <p></p> <p>The very old <span class="hlt">big</span> bang (BB) problems (of the singularity, smoothness, horizon, and flatness) and the failed solutions of inflation theory; newer BB problems relating to missing mass (as required for a flat inflationary universe), the age of the universe, radiation from the "decoupling" ("smearing" of blackbody spectrum), a contrived BB chronology, the abundances of light elements, and redshift anomalies; and problems, newer yet regarding inconsistencies of redshift interpretation, curved space, inflation theory, the decelerating expansion of a BB universe, and some additional logical inconsistencies of BB theory are presented.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://adsabs.harvard.edu/abs/2015PhTea..53..140L','NASAADS'); return false;" href="http://adsabs.harvard.edu/abs/2015PhTea..53..140L"><span id="translatedtitle">The LHC's Next <span class="hlt">Big</span> Mystery</span></a></p> <p><a target="_blank" href="http://adsabs.harvard.edu/abstract_service.html">NASA Astrophysics Data System (ADS)</a></p> <p>Lincoln, Don</p> <p>2015-03-01</p> <p>When the sun rose over America on July 4, 2012, the world of science had radically changed. The Higgs boson had been discovered. Mind you, the press releases were more cautious than that, with "a new particle consistent with being the Higgs boson" being the carefully constructed phrase of the day. But, make no mistake, champagne corks were popped and backs were slapped. The data had spoken and a party was in order. Even if the observation turned out to be something other than the Higgs boson, the first <span class="hlt">big</span> discovery from data taken at the Large Hadron Collider had been made.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/22307937','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/22307937"><span id="translatedtitle">Traffic information computing platform for <span class="hlt">big</span> data</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Duan, Zongtao Li, Ying Zheng, Xibin Liu, Yan Dai, Jiting Kang, Jun</p> <p>2014-10-06</p> <p><span class="hlt">Big</span> data environment create data conditions for improving the quality of traffic information service. The target of this article is to construct a traffic information computing platform for <span class="hlt">big</span> data environment. Through in-depth analysis the connotation and technology characteristics of <span class="hlt">big</span> data and traffic information service, a distributed traffic atomic information computing platform architecture is proposed. Under the <span class="hlt">big</span> data environment, this type of traffic atomic information computing architecture helps to guarantee the traffic safety and efficient operation, more intelligent and personalized traffic information service can be used for the traffic information users.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/27332330','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/27332330"><span id="translatedtitle">Urgent Call for Nursing <span class="hlt">Big</span> Data.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Delaney, Connie W</p> <p>2016-01-01</p> <p>The purpose of this panel is to expand internationally a National Action Plan for sharable and comparable nursing data for quality improvement and <span class="hlt">big</span> data science. There is an urgent need to assure that nursing has sharable and comparable data for quality improvement and <span class="hlt">big</span> data science. A national collaborative - Nursing Knowledge and <span class="hlt">Big</span> Data Science includes multi-stakeholder groups focused on a National Action Plan toward implementing and using sharable and comparable nursing <span class="hlt">big</span> data. Panelists will share accomplishments and future plans with an eye toward international collaboration. This presentation is suitable for any audience attending the NI2016 conference. PMID:27332330</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/25023020','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/25023020"><span id="translatedtitle"><span class="hlt">Big</span> data: an introduction for librarians.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Hoy, Matthew B</p> <p>2014-01-01</p> <p>Modern life produces data at an astounding rate and shows no signs of slowing. This has lead to new advances in data storage and analysis and the concept of "<span class="hlt">big</span> data," that is, massive data sets that can yield surprising insights when analyzed. This column will briefly describe what <span class="hlt">big</span> data is and why it is important. It will also briefly explore the possibilities and problems of <span class="hlt">big</span> data and the implications it has for librarians. A list of <span class="hlt">big</span> data projects and resources is also included. PMID:25023020</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://eric.ed.gov/?q=Brother+AND+analysis&id=EJ862683','ERIC'); return false;" href="http://eric.ed.gov/?q=Brother+AND+analysis&id=EJ862683"><span id="translatedtitle">"I like that He Always Shows Who He Is": The Perceptions and Experiences of Siblings with a <span class="hlt">Brother</span> with Autism Spectrum Disorder</span></a></p> <p><a target="_blank" href="http://www.eric.ed.gov/ERICWebPortal/search/extended.jsp?_pageLabel=advanced">ERIC Educational Resources Information Center</a></p> <p>Petalas, Michael A.; Hastings, Richard P.; Nash, Susie; Dowey, Alan; Reilly, Deirdre</p> <p>2009-01-01</p> <p>Semi-structured interviews were used to explore the perceptions and experiences of eight typically developing siblings in middle childhood who had a <span class="hlt">brother</span> with autism spectrum disorder (ASD). The interviews were analysed using interpretative phenomenological analysis (IPA). The analysis yielded five main themes: (i) siblings' perceptions of the…</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.osti.gov/scitech/biblio/254378','SCIGOV-STC'); return false;" href="http://www.osti.gov/scitech/biblio/254378"><span id="translatedtitle">Two <span class="hlt">sisters</span> with clinical diagnosis of Wiskott-Aldrich Syndrome: Is the condition in the family autosomal recessive?</span></a></p> <p><a target="_blank" href="http://www.osti.gov/scitech">SciTech Connect</a></p> <p>Kondoh, T.; Hayashi, K.; Matsumoto, T.</p> <p>1995-10-09</p> <p>We report two <span class="hlt">sisters</span> in a family representing manifestations of Wiskott-Aldrich syndrome (WAS), an X-linked immunodeficiency disorder. An elder <span class="hlt">sister</span> had suffered from recurrent infections, small thrombocytopenic petechiae, purpura, and eczema for 7 years. The younger <span class="hlt">sister</span> had the same manifestations as the elder <span class="hlt">sister`s</span> for a 2-year period, and died of intracranial bleeding at age 2 years. All the laboratory data of the two patients were compatible with WAS, although they were females. Sialophorin analysis with the selective radioactive labeling method of this protein revealed that in the elder <span class="hlt">sister</span> a 115-KD band that should be specific for sialophorin was reduced in quantity, and instead an additional 135-KD fragment was present as a main band. Polymerase chain reaction (PCR) analysis of the sialophorin gene and single-strand conformation polymorphism (SSCP) analysis of the PCR product demonstrated that there were no detectable size-change nor electrophoretic mobility change in the DNA from both patients. The results indicated that their sialophorin gene structure might be normal. Studies on the mother-daughter transmission of X chromosome using a pERT84-MaeIII polymorphic marker mapped at Xp21 and HPRT gene polymorphism at Xq26 suggested that each <span class="hlt">sister</span> had inherited a different X chromosome from the mother. Two explanations are plausible for the occurrence of the WAS in our patients: the WAS in the patients is attributable to an autosomal gene mutation which may regulate the sialophorin gene expression through the WAS gene, or, alternatively, the condition in this family is an autosomal recessive disorder separated etiologically from the X-linked WAS. 17 refs., 6 figs., 1 tab.</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/16802858','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/16802858"><span id="translatedtitle">Metazoan Scc4 homologs link <span class="hlt">sister</span> chromatid cohesion to cell and axon migration guidance.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Seitan, Vlad C; Banks, Peter; Laval, Steve; Majid, Nazia A; Dorsett, Dale; Rana, Amer; Smith, Jim; Bateman, Alex; Krpic, Sanja; Hostert, Arnd; Rollins, Robert A; Erdjument-Bromage, Hediye; Tempst, Paul; Benard, Claire Y; Hekimi, Siegfried; Newbury, Sarah F; Strachan, Tom</p> <p>2006-07-01</p> <p>Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating <span class="hlt">sister</span> chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein-protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious <span class="hlt">sister</span> chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that <span class="hlt">sister</span> chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development. PMID:16802858</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1484498','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1484498"><span id="translatedtitle">Metazoan Scc4 Homologs Link <span class="hlt">Sister</span> Chromatid Cohesion to Cell and Axon Migration Guidance</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p>Seitan, Vlad C; Banks, Peter; Laval, Steve; Majid, Nazia A; Dorsett, Dale; Rana, Amer; Smith, Jim; Bateman, Alex; Krpic, Sanja; Hostert, Arnd; Rollins, Robert A; Erdjument-Bromage, Hediye; Tempst, Paul; Benard, Claire Y; Hekimi, Siegfried; Newbury, Sarah F</p> <p>2006-01-01</p> <p>Saccharomyces cerevisiae Scc2 binds Scc4 to form an essential complex that loads cohesin onto chromosomes. The prevalence of Scc2 orthologs in eukaryotes emphasizes a conserved role in regulating <span class="hlt">sister</span> chromatid cohesion, but homologs of Scc4 have not hitherto been identified outside certain fungi. Some metazoan orthologs of Scc2 were initially identified as developmental gene regulators, such as Drosophila Nipped-B, a regulator of cut and Ultrabithorax, and delangin, a protein mutant in Cornelia de Lange syndrome. We show that delangin and Nipped-B bind previously unstudied human and fly orthologs of Caenorhabditis elegans MAU-2, a non-axis-specific guidance factor for migrating cells and axons. PSI-BLAST shows that Scc4 is evolutionarily related to metazoan MAU-2 sequences, with the greatest homology evident in a short N-terminal domain, and protein–protein interaction studies map the site of interaction between delangin and human MAU-2 to the N-terminal regions of both proteins. Short interfering RNA knockdown of human MAU-2 in HeLa cells resulted in precocious <span class="hlt">sister</span> chromatid separation and in impaired loading of cohesin onto chromatin, indicating that it is functionally related to Scc4, and RNAi analyses show that MAU-2 regulates chromosome segregation in C. elegans embryos. Using antisense morpholino oligonucleotides to knock down Xenopus tropicalis delangin or MAU-2 in early embryos produced similar patterns of retarded growth and developmental defects. Our data show that <span class="hlt">sister</span> chromatid cohesion in metazoans involves the formation of a complex similar to the Scc2-Scc4 interaction in the budding yeast. The very high degree of sequence conservation between Scc4 homologs in complex metazoans is consistent with increased selection pressure to conserve additional essential functions, such as regulation of cell and axon migration during development. PMID:16802858</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4993918','PMC'); return false;" href="http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=4993918"><span id="translatedtitle">Two Cases of Endometrial Cancer in Twin <span class="hlt">Sisters</span> with Myotonic Dystrophy</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pmc">PubMed Central</a></p> <p></p> <p>2016-01-01</p> <p>We describe two cases of endometrial cancer (EC) occurring in nulligravid twin <span class="hlt">sisters</span> with myotonic dystrophy. Both tested negative for Lynch syndrome and both were treated with laparoscopic hysterectomy with bilateral salpingooophorectomy and adjuvant radiotherapy. Although EC tends to run in families, the diagnosis in itself is not considered sufficient cause for screening or prophylactic measures in close relatives. However, the presence of additional risk factors, such as nulligravidity and myotonic dystrophy in the underlying cases, may call for extra vigilance in first-degree family members. PMID:27595026</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/2585535','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/2585535"><span id="translatedtitle">Genotoxicity evaluation in patients on phenobarbital monotherapy by <span class="hlt">sister</span> chromatid exchange.</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Schaumann, B A; Winge, V B; Pederson, M</p> <p>1989-01-01</p> <p>The potential of phenobarbital to interact with DNA has been studied using the <span class="hlt">sister</span> chromatid exchange (SCE) assay in peripheral lymphocytes of nine adult male patients with epilepsy and of their matched controls. All patients were otherwise healthy individuals, treated chronically with phenobarbital in monotherapy. No statistically significant differences in SCE levels were found between the patient and control groups. Smoking was associated with increased SCE frequencies. The experiment was repeated with five available patients, using a slightly modified methodology. Although different SCE scores were obtained, the results of both tests were comparable. PMID:2585535</p> </li> <li> <p><a target="_blank" onclick="trackOutboundLink('http://www.ncbi.nlm.nih.gov/pubmed/24598400','PUBMED'); return false;" href="http://www.ncbi.nlm.nih.gov/pubmed/24598400"><span id="translatedtitle">Diet transiently improves migraine in two twin <span class="hlt">sisters</span>: possible role of ketogenesis?</span></a></p> <p><a target="_blank" href="http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?DB=pubmed">PubMed</a></p> <p>Di Lorenzo, Cherubino; Currà, Antonio; Sirianni, Giulio; Coppola, Gianluca; Bracaglia, Martina; Cardillo, Alessandra; De Nardis, Lorenzo; Pierelli, Francesco</p> <p>2013-01-01</p> <p>The ketogenic diet is a high-fat, low-carbohydrate diet long used to treat refractory epilepsy; ketogenesis (ketone body formation) is a physiological phenomenon also observed in patients following lowcarbohydrate, low-calorie diets prescribed for rapid weight loss. We report the case of a pair of twin <span class="hlt">sisters</span>, whose high-frequency migraine improved during a ketogenic diet they followed in order to lose weight. The observed time-lock between ketogenesis and migraine improvement provides some insight into how ketones act to improve migraine. 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