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Sample records for calorimetre electromagnetique du

  1. Quantification du champ electromagnetique et description quantique de la generation du second harmonique a l'interieur d'une microcavite

    NASA Astrophysics Data System (ADS)

    Collette, Marc

    L'existence de particules virtuelles qui surgissent spontanement du vide pour disparaitre tres peu de temps apres leur apparition (les fluctuations du vide) trouve son origine dans le principe d'incertitude de Heisenberg. Par ailleurs, on sait que le phenomene de resonance par confinement explique l'amplification de l'intensite lumineuse a l'interieur d'une cavite ouverte aux frequences de resonances de celle-ci. C'est pourquoi le taux d'apparition des photons virtuels au sein des modes propres d'une cavite est lui aussi amplifie par le resonateur. Mathematiquement, cet effet quantique est decrit par l'existence d'un commutateur " anomal " entre les operateurs d'annihilation et de creation des photons. Nous decrivons les consequences de ce commutateur sur la generation du second harmonique optique (GSH), un processus photonique ou, dans un materiau optiquement non lineaire, deux photons de meme energie fusionnent pour n'en former qu'un seul. On commence ce travail avec un traitement complet et original sur la quantification du champ electromagnetique. On montre ensuite que les fluctuations du vide stimulent le signal de la GSH a l'interieur du milieu confine. Cependant, on constate aussi que les fluctuations du vide jouent le role d'un inhibiteur au declenchement du processus, c'est-a-dire que le seuil de la GSH augmente (il est superieur au seuil minimal de deux photons seulement). En conclusion, les mecanismes intimes de certains processus optiques non lineaires doivent etre reconsideres lorsqu'ils surviennent en presence d'un confinement electromagnetique.

  2. Device for calorimetric measurement

    DOEpatents

    King, William P; Lee, Jungchul

    2015-01-13

    In one aspect, provided herein is a single crystal silicon microcalorimeter, for example useful for high temperature operation and long-term stability of calorimetric measurements. Microcalorimeters described herein include microcalorimeter embodiments having a suspended structure and comprising single crystal silicon. Also provided herein are methods for making calorimetric measurements, for example, on small quantities of materials or for determining the energy content of combustible material having an unknown composition.

  3. Calorimetric gas sensor

    DOEpatents

    Ricco, A.J.; Hughes, R.C.; Smith, J.H.; Moreno, D.J.; Manginell, R.P.; Senturia, S.D.; Huber, R.J.

    1998-11-10

    A combustible gas sensor is described that uses a resistively heated, noble metal-coated, micromachined polycrystalline Si filament to calorimetrically detect the presence and concentration of combustible gases. The filaments tested to date are 2 {micro}m thick {times} 10{micro}m wide {times} 100, 250, 500, or 1000 {micro}m-long polycrystalline Si; some are overcoated with a 0.25 {micro}m-thick protective CVD Si{sub 3}N{sub 4} layer. A thin catalytic Pt film was deposited by CVD from the precursor Pt(acac){sub 2} onto microfilaments resistively heated to approximately 500 C; Pt deposits only on the hot filament. Using a constant-resistance-mode feedback circuit, Pt-coated filaments operating at ca. 300 C (35 mW input power) respond linearly, in terms of the change in supply current required to maintain constant resistance (temperature), to H{sub 2} concentrations between 100 ppm and 1% in an 80/20 N{sub 2}/O{sub 2} mixture. Other catalytic materials can also be used. 11 figs.

  4. Calorimetric gas sensor

    DOEpatents

    Ricco, Antonio J.; Hughes, Robert C.; Smith, James H.; Moreno, Daniel J.; Manginell, Ronald P.; Senturia, Stephen D.; Huber, Robert J.

    1998-01-01

    A combustible gas sensor that uses a resistively heated, noble metal-coated, micromachined polycrystalline Si filament to calorimetrically detect the presence and concentration of combustible gases. The filaments tested to date are 2 .mu.m thick.times.10 .mu.m wide.times.100, 250, 500, or 1000 .mu.m-long polycrystalline Si; some are overcoated with a 0.25 .mu.m-thick protective CVD Si.sub.3 N.sub.4 layer. A thin catalytic Pt film was deposited by CVD from the precursor Pt(acac).sub.2 onto microfilaments resistively heated to approximately 500.degree. C.; Pt deposits only on the hot filament. Using a constant-resistance-mode feedback circuit, Pt-coated filaments operating at ca. 300.degree. C. (35 mW input power) respond linearly, in terms of the change in supply current required to maintain constant resistance (temperature), to H.sub.2 concentrations between 100 ppm and 1% in an 80/20 N.sub.2 /O.sub.2 mixture. Other catalytic materials can also be used.

  5. Calorimetric thermobarometry of experimentally shocked quartz

    NASA Technical Reports Server (NTRS)

    Ocker, Katherine D.; Gooding, James L.; Hoerz, Friedrich

    1994-01-01

    Structural damage in experimentally shock-metamorphosed, granular quartz is quantitatively measurable by differential scanning calorimetry (DSC). Shock-induced loss of crystallinity is witnessed by disappearance of the alpha/beta phase transformation and evolution of a broad endoenthalpic strain peak at 650-900 K. The strain-energy peak grows rapidly at less than 10 GPa but declines with increasing shock pressure; it approaches zero at 32 GPa where vitrification is extensive. Effects of grain size and post-shock thermal history must be better understood before calorimetric thermobarometry of naturally shocked samples becomes possible.

  6. Calorimetric and Magnetic Study of the Holmium

    NASA Astrophysics Data System (ADS)

    Henry, Laurence L.

    Calorimetric measurements have been performed on a series of cubic Laves phase compounds Ho(Co _{rm 1-x}Rh_ {rm x})_2 for x = 0.02, 0.05, 0.08, 0.12, 0.16, and 0.25. The heat capacity data show first-order type peaks at the ferromagnetic transition temperature T_{rm c} for concentrations with x- values between 0.02 and 0.08. For larger concentrations, the peaks at T_{rm c} are much broader and more suggestive of a second-order transition. Utilizing the "s-d" model in conjunction with the specific heat data suggests that the change from first- to second-order in the ferromagnetic transition for x _sp{ ~}{>} 0.10 is due to a reduction in the magnetic exchange interactions between the Ho 4f moments and the cobalt 3d electrons. In addition, the calorimetric data for x <=q 0.16 show another first-order peak at a lower temperature T _{rm sf} which can be associated with a change in the easy magnetization direction of the Ho moments.

  7. New calorimetric all-particle energy spectrum

    NASA Technical Reports Server (NTRS)

    Linsley, J.

    1985-01-01

    Both the maximum size N sub m and the sea level muon size N sub mu have been used separately to find the all-particle energy spectrum in the air shower domain. However the conversion required, whether from N sub m to E or from N sub mu to E, has customarily been carried out by means of calculations based on an assumed cascase model. It is shown here that by combining present data on N sub m and N sub mu spectra with data on: (1); the energy spectrum of air shower muons and (2) the average width of the electron profile, one can obtain empirical values of the N sub m to E and N sub mu to E conversion factors, and an empirical calorimetric all-particle spectrum, in the energy range 2 x 10 to the 6th power E 2 x 10 to the 9th power GeV.

  8. Radiation beam calorimetric power measurement system

    DOEpatents

    Baker, John; Collins, Leland F.; Kuklo, Thomas C.; Micali, James V.

    1992-01-01

    A radiation beam calorimetric power measurement system for measuring the average power of a beam such as a laser beam, including a calorimeter configured to operate over a wide range of coolant flow rates and being cooled by continuously flowing coolant for absorbing light from a laser beam to convert the laser beam energy into heat. The system further includes a flow meter for measuring the coolant flow in the calorimeter and a pair of thermistors for measuring the temperature difference between the coolant inputs and outputs to the calorimeter. The system also includes a microprocessor for processing the measured coolant flow rate and the measured temperature difference to determine the average power of the laser beam.

  9. Calorimetric study of peroxycarboxylic ester synthesis.

    PubMed

    Fritzsche, L; Knorr, A

    2009-04-30

    Exothermic reactions involving organic peroxides carry a high potential hazard and must be considered with care. A safe handling requires, among others, the assessment of thermal process safety, for which safety characteristics like overall heat production and the resulting adiabatic temperature rise are essential. The article presents the results of the calorimetric investigation of the synthesis of four peroxycarboxylic esters, three tert-Butyl and one tert-Amyl peroxycarboxylic ester. In the two-step synthesis the second one clearly shows the higher exothermic potential. The overall heat production lies in the range of 126-135 kJ/mol and is nearly independent of the carboxylic acid residual in the tert-Butyl peroxycarboxylic ester. The calculated adiabatic temperature rise is 70-80K. Influence of temperature and feed rate on the heat generation is discussed for one species. A grading of the synthesis with respect to temperature levels according to the criticality classes by Stoessel leads to the most critical for an exothermic reaction. PMID:18722058

  10. The CALorimetric Electron Telescope, CALET, Mission

    NASA Astrophysics Data System (ADS)

    Torii, Shoji

    We are developing the CALorimetric Electron Telescope, CALET, mission for the Japanese Experiment Module Exposed Facility, JEM-EF, of the International Space Station. Major scientific objectives are to search for nearby cosmic ray sources and dark matter by carrying out a precise measurement of the electrons in GeV 20 TeV and the gamma-rays in 20 MeV TeV. CALET has a unique capability to observe electrons and gamma-rays over 1 TeV since the hadron rejection power is more than 105 and the energy resolution better than a few percent over 100 GeV. The detector consists of an Imaging Calorimeter (IMC) with scintillating fiber belts and tungsten plates, a Total Absorption Calorimeter (TASC) with BGO logs, a Silicon Pixel Array (SIA) and a Scintillator Anti-Coincidence System (SACS). CALET has also a capability to measure protons and nuclei in 10 GeV 1000 TeV, and will have a function to monitor solar activity and gamma-ray bursts with additional instruments. The phase A study has started on a schedule of launch in 2013 by H-II Transfer Vehicle (HTV) for 5 years observation.

  11. Etude des phenomenes dynamiques ultrarapides et des caracteristiques impulsionnelles d'emission terahertz du supraconducteur YBCO

    NASA Astrophysics Data System (ADS)

    Savard, Stephane

    Les premieres etudes d'antennes a base de supraconducteurs a haute temperature critique emettant une impulsion electromagnetique dont le contenu en frequence se situe dans le domaine terahertz remontent a 1996. Une antenne supraconductrice est formee d'un micro-pont d'une couche mince supraconductrice sur lequel un courant continu est applique. Un faisceau laser dans le visible est focalise sur le micro-pont et place le supraconducteur dans un etat hors-equilibre ou des paires sont brisees. Grace a la relaxation des quasiparticules en surplus et eventuellement de la reformation des paires supraconductrices, nous pouvons etudier la nature de la supraconductivite. L'analyse de la cinetique temporelle du champ electromagnetique emis par une telle antenne terahertz supraconductrice s'est averee utile pour decrire qualitativement les caracteristiques de celle-ci en fonction des parametres d'operation tels que le courant applique, la temperature et la puissance d'excitation. La comprehension de l'etat hors-equilibre est la cle pour comprendre le fonctionnement des antennes terahertz supraconductrices a haute temperature critique. Dans le but de comprendre ultimement cet etat hors-equilibre, nous avions besoin d'une methode et d'un modele pour extraire de facon plus systematique les proprietes intrinseques du materiau qui compose l'antenne terahertz a partir des caracteristiques d'emission de celle-ci. Nous avons developpe une procedure pour calibrer le spectrometre dans le domaine temporel en utilisant des antennes terahertz de GaAs bombarde aux protons H+ comme emetteur et detecteur. Une fois le montage calibre, nous y avons insere une antenne emettrice dipolaire de YBa 2Cu3O7-delta . Un modele avec des fonctions exponentielles de montee et de descente du signal est utilise pour lisser le spectre du champ electromagnetique de l'antenne de YBa 2Cu3O7-delta, ce qui nous permet d'extraire les proprietes intrinseques de ce dernier. Pour confirmer la validite du modele

  12. Micro-calorimetric sensor for trace explosive particle detection

    NASA Astrophysics Data System (ADS)

    Olsen, Jesper K.; Greve, Anders; Privorotskaya, N.; Senesac, L.; Thundat, T.; King, W. P.; Boisen, A.

    2010-04-01

    A micro differential thermal analysis (DTA) system is used for detection of trace explosive particles. The DTA system consists of two silicon micro chips with integrated heaters and temperature sensors. One chip is used for reference and one for the measurement sample. The sensor is constructed as a small silicon nitride bridge incorporating heater elements and a temperature measurement resistor. In this manuscript the DTA system is described and tested by measuring calorimetric response of DNT (2,4-Dinitrotoluene). The design of the senor is described and the temperature uniformity investigated using finite element modelings and Raman temperature measurements. The functionality is tested using two different kinds of explosive deposition techniques and calorimetric responses are obtained. Under the framework of the Xsense project at the Technical University of Denmark (DTU) which combines four independent sensing techniques, these micro DNT sensors will be included in handheld explosives detectors with applications in homeland security and landmine clearance.

  13. Thermodynamic properties by non-calorimetric methods. Final report

    SciTech Connect

    Steele, W.V.; Chirico, R.D.; Collier, W.B.; Strube, M.M.; Klots, T.D. |

    1992-12-31

    This research program provided a valuable complement to the experimental programs currently in progress at NIPER for the Advanced Research and Technology Development (AR and TD) and Advanced Exploration and Process Technology (AEPT) divisions of the Department of Energy. These experimental programs are focused on the calorimetric determination of thermodynamic properties of key polynuclear heteroatom-containing aromatic molecules. The project for the Office of Energy Research focused on the non-calorimetric determination of thermodynamic properties through the extension of existing correlation methodologies and through molecular spectroscopy with statistical mechanics. The paper discusses the following studies: Group-contribution approach for polycyclic aromatic hydrocarbons (naphthalene, phenanthrene, anthracene, pyrene, 3-methylphenanthrene, benzoquinolines, biphenyl/hydrogen system); Group-contribution approach for key monocyclic organic compounds; Molecular spectroscopy and statistical mechanics; and Thermophysical property correlations.

  14. Measurement of the calorimetric energy scale in MINOS

    SciTech Connect

    Hartnell, Jeffrey J.

    2005-06-01

    MINOS is a long-baseline neutrino oscillation experiment. A neutrino beam is created at the Fermi National Accelerator Laboratory in Illinois and fired down through the Earth. Measurements of the energy spectra and composition of the neutrino beam are made both at the source using the Near detector and 735 km away at the Soudan Underground Laboratory in Minnesota using the Far detector. By comparing the spectrum and flavour composition of the neutrino beam between the two detectors neutrino oscillations can be observed. Such a comparison depends on the accuracy of the relative calorimetric energy scale. This thesis details a precise measurement of the calorimetric energy scale of the MINOS Far detector and Calibration detector using stopping muons with a new ''track window'' technique. These measurements are used to perform the relative calibration between the two detectors. This calibration has been accomplished to 1.7% in data and to significantly better than 2% in the Monte Carlo simulation, thus achieving the MINOS relative calibration target of 2%. A number of cross-checks have been performed to ensure the robustness of the calorimetric energy scale measurements. At the Calibration detector the test-beam energy between run periods is found to be consistent with the detector response to better than 2% after the relative calibration is applied. The muon energy loss in the MINOS detectors determined from Bethe-Bloch predictions, data and Monte Carlo are compared and understood. To estimate the systematic error on the measurement of the neutrino oscillation parameters caused by a relative miscalibration a study is performed. A 2% relative miscalibration is shown to cause a 0.6% bias in the values of {Delta}m{sup 2} and sin{sup 2}(2{theta}).

  15. A no-calorimetric method for measuring SAR in MRI

    NASA Astrophysics Data System (ADS)

    Romano, Rocco; Acernese, Fausto; Barone, Fabrizio

    2011-04-01

    During an MR procedure, the patient absorbs a portion of the transmitted RF energy, which may result in tissue heating and other adverse effects, such as alterations in visual, auditory and neural functions. The Specific Absorption Rate (SAR), in W/kg, is the RF power absorbed per unit mass of tissue and is one of the most important parameters related with thermal effects and acts as a guideline for MRI safety. Strict limits to the SAR levels are imposed by patient safety international regulations (CEI - EN 60601 - 2 - 33) and SAR measurements are required in order to verify its respect. The recommended methods for mean SAR measurement are quite problematic and often require a maintenance man intervention and long stop machine. For example, in the CEI recommended pulse energy method, the presence of a maintenance man is required in order to correctly connect the required instrumentation; furthermore, the procedure is complex and requires remarkable processing and calculus. Simpler are the calorimetric methods, also if in this case long acquisition times are required in order to have significant temperature variations and accurate heat capacity knowledge (CEI - EN 60601 - 2 - 33). The phase transition method is a new no-calorimetric method to measure SAR in MRI which has the advantages to be very simple and to overcome all the typical calorimetric method problems. It does not require in gantry temperature measurements, any specific heat or heat capacity knowledge, but only mass and time measurement. On the other hand, it is necessary to establish if all deposited power SAR can be considered acquired and measured. In this paper, that will be shown.

  16. The Level-0 calorimetric trigger of the NA62 experiment

    NASA Astrophysics Data System (ADS)

    Ammendola, R.; Barbanera, M.; Bizzarri, M.; Bonaiuto, V.; Ceccucci, A.; Checcucci, B.; De Simone, N.; Fantechi, R.; Federici, L.; Fucci, A.; Lupi, M.; Paoluzzi, G.; Papi, A.; Piccini, M.; Ryjov, V.; Salamon, A.; Salina, G.; Sargeni, F.; Venditti, S.

    2016-02-01

    The NA62 experiment at the CERN SPS aims at measuring the branching ratio of the very rare kaon decay K+ → π+ ν bar nu (expected 10-10) with a 10% background. Since an high-intensity kaon beam is required to collect enough statistics, the Level-0 trigger plays a fundamental role in both the background rejection and in the particle identification. The calorimetric trigger collects data from various calorimeters and it is able to identify clusters of energy deposit and determine their position, fine-time and energy. This paper describes the complete hardware commisioning and the setup of the trigger for the 2015 physics data taking.

  17. ASIC for calorimetric measurements in the astrophysical experiment NUCLEON

    NASA Astrophysics Data System (ADS)

    Atkin, E.; Voronin, A.; Karmanov, D.; Kudryashov, I.; Kovalev, I.; Shumikhin, V.

    2016-02-01

    A satellite with the NUCLEON apparatus was launched in Dec. 2014. The space NUCLEON project of ROSCOSMOS is designed to investigate cosmic ray nuclei energy spectra from 100 GeV to 1000 TeV as well as cosmic ray electron spectra from 20 GeV to 3 TeV. The method of energy determination by means of a silicon instrument for measuring the particle charge of cosmic rays and the calorimetric system were developed. The main parameters, that determine the quality of calorimetric systems are linearity of transfer characteristic and the dynamic range of input signals, which should reach 30 000 MIPs (minimum ionizing particles). The ASIC, satisfying these requirements, consisting of 32 channels with a unique dynamic range from 1 to 40000 MIPs, signal to noise ratio not less than 2.5 at a shaper peaking time of 2 μs and a low power consumption of 1.5 mW/channel has been designed. The first results of the ASIC functionality in space are presented.

  18. Adiabatic calorimetric decomposition studies of 50 wt.% hydroxylamine/water.

    PubMed

    Cisneros, L O; Rogers, W J; Mannan, M S

    2001-03-19

    Calorimetric data can provide a basis for determining potential hazards in reactions, storage, and transportation of process chemicals. This work provides calorimetric data for the thermal decomposition behavior in air of 50wt.% hydroxylamine/water (HA), both with and without added stabilizers, which was measured in closed cells with an automatic pressure tracking adiabatic calorimeter (APTAC). Among the data provided are onset temperatures, reaction order, activation energies, pressures of noncondensable products, thermal stability at 100 degrees C, and the effect of HA storage time. Discussed also are the catalytic effects of carbon steel, stainless steel, stainless steel with silica coating, inconel, titanium, and titanium with silica coating on the reaction self-heat rates and onset temperatures. In borosilicate glass cells, HA was relatively stable at temperatures up to 133 degrees C, where the HA decomposition self-heat rate reached 0.05 degrees C/min. The added stabilizers appeared to reduce HA decomposition rates in glass cells and at ambient temperatures. The tested metals and metal surfaces coated with silica acted as catalysts to lower the onset temperatures and increase the self-heat rates. PMID:11165058

  19. Novel micro-calorimetric spectroscopy for mine detection

    SciTech Connect

    Datskos, P.G. |; Rajic, S.; Egert, C.M.; Datskou, I.

    1998-03-01

    The authors have developed a novel micro-calorimetric spectroscopy technique that can be used in mine detection applications. In this technique target molecules are allowed to adsorb on the surface of sub-femtojoule sensitive micromechanical thermal detectors. The adsorption of molecules on the thermal detector surface causes a differential surface stress resulting in an initial trigger. By exposing each element in an array of thermal detectors to different photon wavelengths, an extremely sensitive and unique photothermal signature response can be obtained. The authors present their results on target chemicals adsorbed on the detector surface at sub-monolayer coverage levels. They will present infrared photothermal spectra for trace concentrations of diisopropyl methylphosphonate (DIMP), and trinitrotoluene (TNT) over the wavelength region 2.5 to 14.5 microns. They found that in the wavelength region 2.5 to 14.5 microns the photothermal spectra of DIMP and TNT exhibit a number of peaks and are in excellent agreement with infrared absorption spectra found in the literature. Chemical detectors based on micro-calorimetric spectroscopy can be used to sensitively sense small number of molecules adsorbed on a thermal detector surface. The photothermal signature resulting from photon irradiation can be used for improved chemical characterization.

  20. Calorimetric study of tellurium rich Se-Te-Sn glasses

    NASA Astrophysics Data System (ADS)

    Heera, Pawan; Kumar, Anup; Jharwal, Manish; Sharma, Raman

    2016-05-01

    We report the calorimetric study of amorphous Se30Te70-x Snx alloys for x= 0, 1.5, 2.5, 4.5 in terms of kinetic parameters. The DSC curves recorded at four different heating rates are analyzed to determine the transition temperatures, activation energy, thermal stability, glass forming ability. The crystallization process has been investigated using Kissinger, Matusita, Augis and Bennett, and Gao and Wang models. Various kinetic parameters have been calculated for a better understanding of the growth mechanism. The glass transition temperatures Tg, onset crystallization Tc, peak crystallization Tp, and melting temperature Tm are found to increase with the increase in Sn content. The system under investigation is found to be thermally stable for at lower at% of Sn. The values of parameters HR, Hw, and S indicate that Glass forming ability (GFA) decays with an increase in Sn content.

  1. Preparation, structural, and calorimetric characterization of bicomponent metallic photonic crystals

    NASA Astrophysics Data System (ADS)

    Kozlov, M. E.; Murthy, N. S.; Udod, I.; Khayrullin, I. I.; Baughman, R. H.; Zakhidov, A. A.

    2007-03-01

    We report preparation and characterization of novel bicomponent metal-based photonic crystals having submicron three-dimensional (3D) periodicity. Fabricated photonic crystals include SiO2 sphere lattices infiltrated interstitially with metals, carbon inverse lattices filled with metal or metal alloy spheres, Sb inverse lattices, and Sb inverse lattices filled with Bi spheres. Starting from a face centered SiO2 lattice template, these materials were obtained by sequences of either templating and template extraction or templating, template extraction, and retemplating. Surprising high fidelity was obtained for all templating and template extraction steps. Scanning electron microscopy (SEM), small angle X-ray scattering (SAXS) and differential scanning calorimetry (DSC) were used to characterize the structure and the effects of the structure on calorimetric properties. To the best of our knowledge, SAXS data on metallic photonic crystals were collected for first time.

  2. Calorimetric determination of the enthalpy of formation for pyrophyllite

    NASA Astrophysics Data System (ADS)

    Ogorodova, L. P.; Kiseleva, I. A.; Mel'Chakova, L. V.; Vigasina, M. F.; Spiridonov, E. M.

    2011-09-01

    A calorimetric study of the natural pyrophyllite was performed by high-temperature melt calorimetry on a Tian-Calvet calorimeter. Based on experimentally determined in this work for pyrophyllite and gibbsite, as well as previously obtained for corundum and quartz, the total value of the enthalpy increment for the sample heated from room temperature to 973 K and the enthalpy of dissolution at 973 K by Hess's law, the enthalpy of formation of pyrophyllite of Al2[(OH)2/Si4O10] composed of elements was calculated at 298.15 K: Δf H {el/o}(298.15 K) = -5639.8 ± 5.7 kJ/mol.

  3. Nanoclay modified polycarbonate blend nanocomposites: Calorimetric and mechanical properties

    NASA Astrophysics Data System (ADS)

    Zicans, Janis; Meri, Remo Merijs; Ivanova, Tatjana; Berzina, Rita; Kalnins, Martins; Maksimovs, Roberts

    2014-05-01

    The research is devoted to characterization of polycarbonate (PC)/acrylonitrile-butadiene styrene (ABS) blend nanocomposites in respects to it mechanical and calorimetric properties. It is shown that PC blend with 10wt% of ABS is more suitable for development of polymer-clay nanocomposites than PC blend with 40wt.% of ABS. It is revealed that the greatest modulus and strength increment is observed for PC/10wt.%ABS blend nanocomposites, containing aromatic organomodifier treated clay (Dellite 43B). It is also determined that optimal nanofiller content for the investigated PC/10%ABS blend is 1.5 wt.%. Increase of mechanical characteristics of PC/10wt.%ABS blend nanocomposites is accompanied with the rise of glass transition temperatures of both polymeric phases, particularly that of PC.

  4. Remote calorimetric detection of urea via flow injection analysis.

    PubMed

    Gaddes, David E; Demirel, Melik C; Reeves, W Brian; Tadigadapa, Srinivas

    2015-12-01

    The design and development of a calorimetric biosensing system enabling relatively high throughput sample analysis are reported. The calorimetric biosensor system consists of a thin (∼20 μm) micromachined Y-cut quartz crystal resonator (QCR) as a temperature sensor placed in close proximity to a fluidic chamber packed with an immobilized enzyme. Layer by layer enzyme immobilization of urease is demonstrated and its activity as a function of the number of layers, pH, and time has been evaluated. This configuration enables a sensing system where a transducer element is physically separated from the analyte solution of interest and is thereby free from fouling effects typically associated with biochemical reactions occuring on the sensor surface. The performance of this biosensing system is demonstrated by detection of 1-200 mM urea in phosphate buffer via a flow injection analysis (FIA) technique. Miniaturized fluidic systems were used to provide continuous flow through a reaction column. Under this configuration the biosensor has an ultimate resolution of less than 1 mM urea and showed a linear response between 0-50 mM. This work demonstrates a sensing modality in which the sensor itself is not fouled or contaminated by the solution of interest and the enzyme immobilized Kapton® fluidic reaction column can be used as a disposable cartridge. Such a system enables reuse and reliability for long term sampling measurements. Based on this concept a biosensing system is envisioned which can perform rapid measurements to detect biomarkers such as glucose, creatinine, cholesterol, urea and lactate in urine and blood continuously over extended periods of time. PMID:26479269

  5. A calorimetric investigation of spessartine: Vibrational and magnetic heat capacity

    NASA Astrophysics Data System (ADS)

    Dachs, Edgar; Geiger, Charles A.; Withers, Anthony C.; Essene, Eric J.

    2009-06-01

    The heat capacity ( Cp) of two synthetic spessartine samples (Sps) was measured on 20-30 mg-size samples in the temperature range 2-864 K by relaxation calorimetry (RC) and differential scanning calorimetry (DSC). The polycrystalline spessartine samples were synthesized in two different laboratories at high pressures and temperatures from glass and oxide-mixture starting materials and characterized by X-ray powder diffraction and electron-microprobe analysis. The low-temperature heat capacity data show a prominent lambda transition with a peak at 6.2 K, which is interpreted to be the result of a paramagnetic-antiferromagnetic phase transition. The DSC data around ambient T agree excellently with the RC data and can be represented by the Cp polynomial for T > 250 K: CpSps=610-3060·T-0.5-1.45·107·T-2+1.82·109·T-3. Integration of the low temperature Cp data yields a calorimetric standard entropy for the two different samples of So = 334.6 ± 2.7 J/mol · K and 336.0 ± 2.7 J/mol · K. The preferred standard third-law entropy for spessartine is So = 335.3 ± 3.8 J/mol · K, which is the mean value from the two separate determinations. The lattice (vibrational) heat capacity of spessartine was calculated using the single-parameter phonon dispersion model of Komada and Westrum. The lattice entropy at 298.15 K is Svib298.15=297.7J/mol·K, which represents 89% of the calorimetric entropy. The magnetic heat capacity and entropy of spessartine, Smag, at 298.15 K were also calculated. The Smag of the two samples is 38.7 and 37.4 J/mol · K, which is 87% and 83% of the maximum possible magnetic entropy given by 3Rln6 = 44.7 J/mol · K. Published model-dependent lattice-dynamic calculations of Svib298.15 are analyzed and compared to the experimental data. Using the calorimetrically determined So and the Cp polynomial for spessartine, together with high P- T experimental phase-equilibrium data on Mn 2+-Mg partitioning between garnet and olivine, allows calculation of the

  6. Calorimetric and relaxation properties of xylitol-water mixtures

    NASA Astrophysics Data System (ADS)

    Elamin, Khalid; Sjöström, Johan; Jansson, Helén; Swenson, Jan

    2012-03-01

    We present the first broadband dielectric spectroscopy (BDS) and differential scanning calorimetry study of supercooled xylitol-water mixtures in the whole concentration range and in wide frequency (10-2-106 Hz) and temperature (120-365 K) ranges. The calorimetric glass transition, Tg, decreases from 247 K for pure xylitol to about 181 K at a water concentration of approximately 37 wt. %. At water concentrations in the range 29-35 wt. % a plentiful calorimetric behaviour is observed. In addition to the glass transition, almost simultaneous crystallization and melting events occurring around 230-240 K. At higher water concentrations ice is formed during cooling and the glass transition temperature increases to a steady value of about 200 K for all higher water concentrations. This Tg corresponds to an unfrozen xylitol-water solution containing 20 wt. % water. In addition to the true glass transition we also observed a glass transition-like feature at 220 K for all the ice containing samples. However, this feature is more likely due to ice dissolution [A. Inaba and O. Andersson, Thermochim. Acta, 461, 44 (2007)]. In the case of the BDS measurements the presence of water clearly has an effect on both the cooperative α-relaxation and the secondary β-relaxation. The α-relaxation shows a non-Arrhenius temperature dependence and becomes faster with increasing concentration of water. The fragility of the solutions, determined by the temperature dependence of the α-relaxation close to the dynamic glass transition, decreases with increasing water content up to about 26 wt. % water, where ice starts to form. This decrease in fragility with increasing water content is most likely caused by the increasing density of hydrogen bonds, forming a network-like structure in the deeply supercooled regime. The intensity of the secondary β-relaxation of xylitol decreases noticeably already at a water content of 2 wt. %, and at a water content above 5 wt. % it has been replaced by a

  7. Estimation of the diversity between DNA calorimetric profiles, differential melting curves and corresponding melting temperatures.

    PubMed

    Chang, Chun-Ling; Fridman, Alexander S; Grigoryan, Inessa E; Galyuk, Elena N; Murashko, Oleg N; Hu, Chin-Kun; Lando, Dmitri Y

    2016-11-01

    The Poland-Fixman-Freire formalism was adapted for modeling of calorimetric DNA melting profiles, and applied to plasmid pBR 322 and long random sequences. We studied the influence of the difference (HGC -HAT ) between the helix-coil transition enthalpies of AT and GC base pairs on the calorimetric melting profile and on normalized calorimetric melting profile. A strong alteration of DNA calorimetrical profile with HGC -HAT was demonstrated. In contrast, there is a relatively slight change in the normalized profiles and in corresponding ordinary (optical) normalized differential melting curves (DMCs). For fixed HGC -HAT , the average relative deviation (S) between DMC and normalized calorimetric profile, and the difference between their melting temperatures (Tcal -Tm ) are weakly dependent on peculiarities of the multipeak fine structure of DMCs. At the same time, both the deviation S and difference (Tcal -Tm ) enlarge with the temperature melting range of the helix-coil transition. It is shown that the local deviation between DMC and normalized calorimetric profile increases in regions of narrow peaks distant from the melting temperature. PMID:27422497

  8. Fructose-selective calorimetric biosensor in flow injection analysis.

    PubMed

    Bhand, Sunil G; Soundararajan, Srimathi; Surugiu-Wärnmark, Ioana; Milea, Jaqueline Simona; Dey, Estera Szwajcer; Yakovleva, Maria; Danielsson, Bengt

    2010-05-23

    A highly selective, interference free biosensor for the measurement of fructose in real syrup samples was developed. The assay is based on the phosphorylation of D(-)fructose to fructose-6-phosphate by hexokinase and subsequent conversion of fructose-6-phosphate to fructose-1,6-biphosphate by fructose-6-phosphate-kinase. The heat liberated in the second reaction is monitored using an enzyme thermistor. The major advantages of this biosensor are rapid and selective measurement of fructose without the need to eliminate glucose and inexpensive FIA-based, mediator-free calorimetric measurement suitable for regular fructose analysis. This method was optimised for parameters, such as pH, ionic strength, interference, operational stability and shelf life. Good and reproducible linearity (0.5-6.0 mM) with a detection limit of 0.12 mM was obtained. Fructose determination in commercial syrup samples and spiked samples confirmed the reliability of this set-up and technique. The biosensor gave reproducible results with good overall stability for continuous measurements over a period of three months besides a useful shelf life of six months. The method could be used for routine fructose monitoring in food samples. PMID:20457296

  9. Differential scanning calorimetric studies of nickel titanium rotary endodontic instruments.

    PubMed

    Brantley, W A; Svec, T A; Iijima, M; Powers, J M; Grentzer, T H

    2002-08-01

    Differential scanning calorimetric (DSC) analyses were performed between -130 degrees and 100 degrees C on specimens prepared from nickel-titanium (NiTi) rotary endodontic instruments: ProFile (n = 5), Lightspeed (n = 4), and Quantec (n = 3). The ProFile and Lightspeed instruments were in the as-received condition, whereas the Quantec instruments were randomly selected from a dental clinic and had unknown history. The DSC plots showed that the ProFile and Lightspeed instruments analyzed had the superelastic NiTi property, with an austenite-finish (Af) temperature of approximately 25 degrees C. Differences in DSC plots for the ProFile instruments and the starting wire blanks (n = 2) were attributed to the manufacturing process. The phase transformation behavior when the specimens were heated and cooled between -130 degrees and 100 degrees C, the temperature ranges for the phase transformations, and the resulting enthalpy changes were similar to those previously reported for nickel-titanium orthodontic wires having superelastic characteristics or shape memory behavior in the oral environment. The experiments demonstrated that DSC is a powerful tool for materials characterization of these rotary instruments, providing direct information not readily available from other analytical techniques about the NiTi phases present, which are fundamentally responsible for their clinical behavior. PMID:12184415

  10. Adiabatic Heat of Hydration Calorimetric Measurements for Reference Saltstone Waste

    SciTech Connect

    Bollinger, James

    2006-01-12

    The production of nuclear materials for weapons, medical, and space applications from the mid-1950's through the late-1980's at the Savannah River Site (SRS) generated approximately 35 million gallons of liquid high-level radioactive waste, which is currently being processed into vitrified glass for long-term storage. Upstream of the vitrification process, the waste is separated into three components: high activity insoluble sludge, high activity insoluble salt, and very low activity soluble salts. The soluble salt represents 90% of the 35 million gallons of overall waste and is processed at the SRS Saltstone Facility, where it mixed with cement, blast furnace slag, and flyash, creating a grout-like mixture. The resulting grout is pumped into aboveground storage vaults, where it hydrates into concrete monoliths, called saltstone, thus immobilizing the low-level radioactive salt waste. As the saltstone hydrates, it generates heat that slowly diffuses out of the poured material. To ensure acceptable grout properties for disposal and immobilization of the salt waste, the grout temperature must not exceed 95 C during hydration. Adiabatic calorimetric measurements of the heat generated for a representative sample of saltstone were made to determine the time-dependent heat source term. These measurements subsequently were utilized as input to a numerical conjugate heat transfer model to determine the expected peak temperatures for the saltstone vaults.

  11. Thermodynamic properties of chlorite and berthierine derived from calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Blanc, Philippe; Gailhanou, Hélène; Rogez, Jacques; Mikaelian, Georges; Kawaji, Hitoshi; Warmont, Fabienne; Gaboreau, Stéphane; Grangeon, Sylvain; Grenèche, Jean-Marc; Vieillard, Philippe; Fialips, Claire I.; Giffaut, Eric; Gaucher, Eric C.; Claret, F.

    2014-09-01

    In the context of the deep waste disposal, we have investigated the respective stabilities of two iron-bearing clay minerals: berthierine ISGS from Illinois [USA; (Al0.975FeIII0.182FeII1.422Mg0.157Li0.035Mn0.002)(Si1.332Al0.668)O5(OH)4] and chlorite CCa-2 from Flagstaff Hill, California [USA; (Si2.633Al1.367)(Al1.116FeIII0.215Mg2.952FeII1.712Mn0.012Ca0.011)O10(OH)8]. For berthierine, the complete thermodynamic dataset was determined at 1 bar and from 2 to 310 K, using calorimetric methods. The standard enthalpies of formation were obtained by solution-reaction calorimetry at 298.15 K, and the heat capacities were measured by heat-pulse calorimetry. For chlorite, the standard enthalpy of formation is measured by solution-reaction calorimetry at 298.15 K. This is completing the entropy and heat capacity obtained previously by Gailhanou et al. (Geochim Cosmochim Acta 73:4738-4749, 2009) between 2 and 520 K, by using low-temperature adiabatic calorimetry and differential scanning calorimetry. For both minerals, the standard entropies and the Gibbs free energies of formation at 298.15 K were then calculated. An assessment of the measured properties could be carried out with respect to literature data. Eventually, the thermodynamic dataset allowed realizing theoretical calculations concerning the berthierine to chlorite transition. The latter showed that, from a thermodynamic viewpoint, the main factor controlling this transition is probably the composition of the berthierine and chlorite minerals and the nature of the secondary minerals rather than temperature.

  12. Calorimetric method for determination of {sup 51}Cr neutrino source activity

    SciTech Connect

    Veretenkin, E. P. Gavrin, V. N.; Danshin, S. N.; Ibragimova, T. V.; Kozlova, Yu. P.; Mirmov, I. N.

    2015-12-15

    Experimental study of nonstandard neutrino properties using high-intensity artificial neutrino sources requires the activity of the sources to be determined with high accuracy. In the BEST project, a calorimetric system for measurement of the activity of high-intensity (a few MCi) neutrino sources based on {sup 51}Cr with an accuracy of 0.5–1% is created. In the paper, the main factors affecting the accuracy of determining the neutrino source activity are discussed. The calorimetric system design and the calibration results using a thermal simulator of the source are presented.

  13. "Cirque du Freak."

    ERIC Educational Resources Information Center

    Rivett, Miriam

    2002-01-01

    Considers the marketing strategies that underpin the success of the "Cirque du Freak" series. Describes how "Cirque du Freak" is an account of events in the life of schoolboy Darren Shan. Notes that it is another reworking of the vampire narrative, a sub-genre of horror writing that has proved highly popular with both adult and child readers. (SG)

  14. Heat capacty, relative enthalpy, and calorimetric entropy of silicate minerals: an empirical method of prediction.

    USGS Publications Warehouse

    Robinson, G.R., Jr.; Haas, J.L., Jr.

    1983-01-01

    Through the evaluation of experimental calorimetric data and estimates of the molar isobaric heat capacities, relative enthalpies and entropies of constituent oxides, a procedure for predicting the thermodynamic properties of silicates is developed. Estimates of the accuracy and precision of the technique and examples of its application are also presented. -J.A.Z.

  15. The du Bois sign.

    PubMed

    Voelpel, James H; Muehlberger, Thomas

    2011-03-01

    According to the current literature, the term "du Bois sign" characterizes the condition of a shortened fifth finger as a symptom of congenital syphilis, Down syndrome, dyscrania, and encephalic malformation. Modern medical dictionaries and text books attribute the eponym to the French gynecologist Paul Dubois (1795-1871). Yet, a literature analysis revealed incorrect references to the person and unclear definitions of the term. Our findings showed that the origin of the term is based on observations made by the Swiss dermatologist Charles du Bois (1874-1947) in connection with congenital syphilis. In addition, a further eponymical fifth finger sign is closely associated with the du Bois sign. In conclusion, the du Bois sign has only limited diagnostic value and is frequently occurring in the normal healthy population. PMID:21263293

  16. The calorimetric spectrum of the electron-capture decay of 163Ho. The spectral endpoint region

    NASA Astrophysics Data System (ADS)

    De Rújula, A.; Lusignoli, M.

    2016-05-01

    The electron-neutrino mass (or masses and mixing angles) may be directly measurable in weak electron-capture decays. The favoured experimental technique is "calorimetric". The optimal nuclide is 163Ho, and several experiments (ECHo, HOLMES and NuMECS) are currently studying its decay. The most relevant range of the calorimetric-energy spectrum extends for the last few hundred eV below its endpoint. It has not yet been well measured. We explore the theory, mainly in the cited range, of electron capture in 163Ho decay. A so far neglected process turns out to be most relevant: electron-capture accompanied by the shake-off of a second electron. Our two main conclusions are very encouraging: the counting rate close to the endpoint may be more than an order of magnitude larger than previously expected; the "pile-up" problem may be significantly reduced.

  17. An Improved Formulation for Calorimetric Emittance Testing of Spacecraft Thermal Control Coatings

    NASA Technical Reports Server (NTRS)

    Kauder, Lonny R.

    2008-01-01

    Spacecraft often really heavily on passive thermal control to maintain operating temperature. An important parameter in the spacecraft heat balance equation is the emittance of thermal control coatings as a function of coating temperature. One method for determining the emittance of spacecraft thermal control from elevated temperature to cryogenic temperatures relies on a calorimetric technique. The fundamental equation governing this test method can be found in numerous places in the literature and although it generally provides reasonable results, its formulation is based on a conceptual flaw that only becomes apparent when the sample temperature approaches the wall temperature during testing. This paper investigates the cause for this error and develops the correct formulation for calorimetric emittance testing. Experimental data will also be presented that illustrates the difference between the two formulations and the resulting difference in the calculated emittance.

  18. GYROTRON POWER BALANCE BASED ON CALORIMETRIC MEASUREMENTS IN THE DIII-D ECH SYSTEM

    SciTech Connect

    GORELOV,I.A; LOHR,J.M; BAITY,JR.,F.W; CAHALAN,P; CALLIS,R.W; PONCE,D; CHIU,H.K

    2003-10-01

    OAK-B135 A powerful microwave system operating at the second harmonic of the electron cyclotron frequency on the DIII-D tokamak was upgraded up to six assemblies of 110 GHz gyrotrons in 2003. three Gycom gyrotrons nominally generate 750 kW for 2 s pulses, with the pulse length limit resulting from the peak temperature allowed on the boron nitride rf output window. Three Communications and Power Industries (CPI) gyrotrons with diamond windows have been recently installed and have been tested to 0.9-1.0 MW for 5 s pulses. Heat loading on internal parts of the gyrotrons, the matching optics unit and the dummy loads is measured calorimetrically. This paper discusses the calorimetry system and calorimetric measurements of gyrotron performance.

  19. Ultra-Responsive Thermal Sensors for the Detection of Explosives Using Calorimetric Spectroscopy (CalSpec)

    SciTech Connect

    Datskos, P.G.; Datskou, I.; Marlar, T.A.; Rajic, S.

    1999-04-05

    We have developed a novel chemical detection technique based on infrared micro-calorimetric spectroscopy that can be used to identify the presence of trace amounts of very low vapor pressure target compounds. Unlike numerous recently developed low-cost sensor approaches, the selectivity is derived from the unique differential temperature spectrum and does not require the questionable reliability of highly selective coatings to achieve the required specificity. This is accomplished by obtaining the infrared micro-calorimetric absorption spectrum of a small number of molecules absorbed on the surface of a thermal detector after illumination through a scanning monochromator. We have obtained infrared micro-calorimetric spectra for explosives such as TNT over the wavelength region 2.5 to 14.5 Mu-m. Thus both sophisticated and relatively crude explosive compounds and components are detectable with these ultra-sensitive thermal-mechanical micro-structures. In addition to the above mentioned spectroscopy technique and associated data, the development of these advanced thermal detectors is also presented in detail.

  20. Nanowell-patterned TiO{sub 2} microcantilevers for calorimetric chemical sensing

    SciTech Connect

    Lee, Dongkyu Chae, Inseok; Thundat, Thomas; Kim, Seonghwan; Jeon, Sangmin

    2014-04-07

    A sensitive calorimetric sensor using a TiO{sub 2} microcantilever with nanowells patterned on one of its sides is described. This single material cantilever is sensitive to temperature change without relying on the metal deposition-based bimetallic effect. The thermomechanical sensitivity originates from the structure dependent variations in both the elastic modulus and thermal expansion coefficient due to the presence of ordered nanowells. These cantilever beams offer an alternate and efficient chemical sensing route for vapor phase analytes using photothermal spectroscopy. Selective and sensitive detection of organophosphorus compounds, as well as their photocatalytic decomposition under ultraviolet light exposure are demonstrated.

  1. Relativistic electron precipitation at International Space Station: Space weather monitoring by Calorimetric Electron Telescope

    NASA Astrophysics Data System (ADS)

    Kataoka, Ryuho; Asaoka, Yoichi; Torii, Shoji; Terasawa, Toshio; Ozawa, Shunsuke; Tamura, Tadahisa; Shimizu, Yuki; Akaike, Yosui; Mori, Masaki

    2016-05-01

    The charge detector (CHD) of the Calorimetric Electron Telescope (CALET) on board the International Space Station (ISS) has a huge geometric factor for detecting MeV electrons and is sensitive to relativistic electron precipitation (REP) events. During the first 4 months, CALET CHD observed REP events mainly at the dusk to midnight sector near the plasmapause, where the trapped radiation belt electrons can be efficiently scattered by electromagnetic ion cyclotron (EMIC) waves. Here we show that interesting 5-20 s periodicity regularly exists during the REP events at ISS, which is useful to diagnose the wave-particle interactions associated with the nonlinear wave growth of EMIC-triggered emissions.

  2. Calorimetric support of directional-hemispherical reflection measurements in the infrared spectral range.

    PubMed

    Richter, W; Sarge, S M; Kämmer, F

    1994-03-01

    Measurements of the directional-hemispherical reflectance ρ with the Physikalisch-Technische Bundesanstalt IR sphere reflectometer have been confirmed by calorimetric determination of the absorptance α in the same geometrical conditions (irradiation at 10°, hemispherical reflection). The good agreement of ρ with (1 - α) on both highly reflecting and low-reflecting surfaces indicates that in the mid-IR spectral range the integrating sphere reflectometer is capable of essentially correct reflectance measurements of diffusely reflecting surfaces, with an estimated uncertainty of 0.01 after correction for a small systematic deviation. This capability opens up the possibility of developing IR reflectance standards. PMID:20862150

  3. Thermodynamic Properties of Liquid Silver-Antimony-Tin Alloys Determined from Electrochemical and Calorimetric Measurements

    NASA Astrophysics Data System (ADS)

    Łapsa, Joanna; Onderka, Bogusław

    2016-05-01

    The thermodynamic properties of liquid Ag-Sb-Sn alloys were obtained through use of the drop solution calorimetric method and electromotive force (emf) measurements of galvanic cells with a yttria stabilized zirconia (YSZ) solid electrolyte. The experiments were carried out along Ag0.25Sb0.75, Ag0.5Sb0.5 and Ag0.75Sb0.25 sections of the ternary system in the temperature range from 973 K to 1223 K. From the measured emf, the tin activity in liquid solutions of Ag-Sb-Sn was determined for the first time. The partial and integral enthalpy of mixing were determined from calorimetric measurements at two temperatures. These measurements were performed along two cross-sections: Sb0.5Sn0.5 at 912 K and 1075 K, and Ag0.75Sb0.25 at 1075 K. Both experimental data sets were used to find ternary interaction parameters by applying the Redlich-Kister-Muggianu model of the substitutional solution. Consequently, the set of parameters describing the thermodynamic properties of the liquid phase was derived.

  4. Kinetics of degradation of diclofenac sodium in aqueous solution determined by a calorimetric method.

    PubMed

    Chadha, R; Kashid, N; Jain, D V S

    2003-09-01

    An isothermal heat conduction microcalorimeter has been used to study the stability of diclofenac sodium both alone and its inclusion complex with beta-cyclodextrin in aqueous solution. The rates of heat evolved during degradation of diclofenac sodium have been measured by a highly sensitive microcalorimetric technique as function of concentration, pH and temperature. The calorimetric accessible data have been incorporated in the equations for determination of rate constants, change in enthalpy and order of reaction. The decomposition of diclofenac sodium both alone and its inclusion complex with beta-cyclodextrin in solution corresponds to a pseudo-first order reaction. The values of rate constants, k's at 338.15 K, (calculated from the variation of heat evolution with the time) for the degradation of diclofenac sodium at pH 5, 6, 7, 8 and its inclusion complex with beta-cyclodextrin at pH 7 are found to be 4.71 x 10(-4), 5.69 x 10(-4), 6.12 x 10(-)4, 6.57 x 10(-4) and 4.26 x 10(-4) h(-1) respectively. There is good agreement between calorimetric determined t(0.5) and literature values. It has been found that beta-cyclodextrin retards the degradation of diclofenac sodium. The kinetic parameters have been calculated for the reaction. The negative entropy of activation suggests the formation of an ordered transition state. PMID:14531458

  5. Calorimetric method of ac loss measurement in a rotating magnetic field.

    PubMed

    Ghoshal, P K; Coombs, T A; Campbell, A M

    2010-07-01

    A method is described for calorimetric ac-loss measurements of high-T(c) superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines. PMID:20687748

  6. Calorimetric method of ac loss measurement in a rotating magnetic field

    NASA Astrophysics Data System (ADS)

    Ghoshal, P. K.; Coombs, T. A.; Campbell, A. M.

    2010-07-01

    A method is described for calorimetric ac-loss measurements of high-Tc superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines.

  7. Thermodynamic Properties of Liquid Silver-Antimony-Tin Alloys Determined from Electrochemical and Calorimetric Measurements

    NASA Astrophysics Data System (ADS)

    Łapsa, Joanna; Onderka, Bogusław

    2016-08-01

    The thermodynamic properties of liquid Ag-Sb-Sn alloys were obtained through use of the drop solution calorimetric method and electromotive force (emf) measurements of galvanic cells with a yttria stabilized zirconia (YSZ) solid electrolyte. The experiments were carried out along Ag0.25Sb0.75, Ag0.5Sb0.5 and Ag0.75Sb0.25 sections of the ternary system in the temperature range from 973 K to 1223 K. From the measured emf, the tin activity in liquid solutions of Ag-Sb-Sn was determined for the first time. The partial and integral enthalpy of mixing were determined from calorimetric measurements at two temperatures. These measurements were performed along two cross-sections: Sb0.5Sn0.5 at 912 K and 1075 K, and Ag0.75Sb0.25 at 1075 K. Both experimental data sets were used to find ternary interaction parameters by applying the Redlich-Kister-Muggianu model of the substitutional solution. Consequently, the set of parameters describing the thermodynamic properties of the liquid phase was derived.

  8. Comparison of the calorimetric and kinematic methods of neutrino energy reconstruction in disappearance experiments

    SciTech Connect

    Ankowski, Artur M.; Benhar, Omar; Coloma, Pilar; Huber, Patrick; Jen, Chun -Min; Mariani, Camillo; Meloni, Davide; Vagnoni, Erica

    2015-10-22

    To be able to achieve their physics goals, future neutrino-oscillation experiments will need to reconstruct the neutrino energy with very high accuracy. In this work, we analyze how the energy reconstruction may be affected by realistic detection capabilities, such as energy resolutions, efficiencies, and thresholds. This allows us to estimate how well the detector performance needs to be determined a priori in order to avoid a sizable bias in the measurement of the relevant oscillation parameters. We compare the kinematic and calorimetric methods of energy reconstruction in the context of two νμ → νμ disappearance experiments operating in different energy regimes. For the calorimetric reconstruction method, we find that the detector performance has to be estimated with an O(10%) accuracy to avoid a significant bias in the extracted oscillation parameters. Thus, in the case of kinematic energy reconstruction, we observe that the results exhibit less sensitivity to an overestimation of the detector capabilities.

  9. Calorimetric method of ac loss measurement in a rotating magnetic field

    SciTech Connect

    Ghoshal, P. K.; Coombs, T. A.; Campbell, A. M.

    2010-07-15

    A method is described for calorimetric ac-loss measurements of high-T{sub c} superconductors (HTS) at 80 K. It is based on a technique used at 4.2 K for conventional superconducting wires that allows an easy loss measurement in parallel or perpendicular external field orientation. This paper focuses on ac loss measurement setup and calibration in a rotating magnetic field. This experimental setup is to demonstrate measuring loss using a temperature rise method under the influence of a rotating magnetic field. The slight temperature increase of the sample in an ac-field is used as a measure of losses. The aim is to simulate the loss in rotating machines using HTS. This is a unique technique to measure total ac loss in HTS at power frequencies. The sample is mounted on to a cold finger extended from a liquid nitrogen heat exchanger (HEX). The thermal insulation between the HEX and sample is provided by a material of low thermal conductivity, and low eddy current heating sample holder in vacuum vessel. A temperature sensor and noninductive heater have been incorporated in the sample holder allowing a rapid sample change. The main part of the data is obtained in the calorimetric measurement is used for calibration. The focus is on the accuracy and calibrations required to predict the actual ac losses in HTS. This setup has the advantage of being able to measure the total ac loss under the influence of a continuous moving field as experienced by any rotating machines.

  10. Comparison of the calorimetric and kinematic methods of neutrino energy reconstruction in disappearance experiments

    DOE PAGESBeta

    Ankowski, Artur M.; Benhar, Omar; Coloma, Pilar; Huber, Patrick; Jen, Chun -Min; Mariani, Camillo; Meloni, Davide; Vagnoni, Erica

    2015-10-22

    To be able to achieve their physics goals, future neutrino-oscillation experiments will need to reconstruct the neutrino energy with very high accuracy. In this work, we analyze how the energy reconstruction may be affected by realistic detection capabilities, such as energy resolutions, efficiencies, and thresholds. This allows us to estimate how well the detector performance needs to be determined a priori in order to avoid a sizable bias in the measurement of the relevant oscillation parameters. We compare the kinematic and calorimetric methods of energy reconstruction in the context of two νμ → νμ disappearance experiments operating in different energymore » regimes. For the calorimetric reconstruction method, we find that the detector performance has to be estimated with an O(10%) accuracy to avoid a significant bias in the extracted oscillation parameters. Thus, in the case of kinematic energy reconstruction, we observe that the results exhibit less sensitivity to an overestimation of the detector capabilities.« less

  11. Calorimetric Thermoelectric Gas Sensor for the Detection of Hydrogen, Methane and Mixed Gases

    PubMed Central

    Park, Nam-Hee; Akamatsu, Takafumi; Itoh, Toshio; Izu, Noriya; Shin, Woosuck

    2014-01-01

    A novel miniaturized calorimeter-type sensor device with a dual-catalyst structure was fabricated by integrating different catalysts on the hot (Pd/θ-Al2O3) and cold (Pt/α-Al2O3) ends of the device. The device comprises a calorimeter with a thermoelectric gas sensor (calorimetric-TGS), combining catalytic combustion and thermoelectric technologies. Its response for a model fuel gas of hydrogen and methane was investigated with various combustor catalyst compositions. The calorimetric-TGS devices detected H2, CH4, and a mixture of the two with concentrations ranging between 200 and 2000 ppm at temperatures of 100–400 °C, in terms of the calorie content of the gases. It was necessary to reduce the much higher response voltage of the TGS to H2 compared to CH4. We enhanced the H2 combustion on the cold side so that the temperature differences and response voltages to H2 were reduced. The device response to H2 combustion was reduced by 50% by controlling the Pt concentration in the Pt/α-Al2O3 catalyst on the cold side to 3 wt%. PMID:24818660

  12. Stabilization of Cu(I) for binding and calorimetric measurements in aqueous solution†

    PubMed Central

    Johnson, Destinee K.; Stevenson, Michael J.; Almadidy, Zayed A.; Jenkins, Sharon E.; Wilcox, Dean. E.; Grossoehme, Nicholas E.

    2015-01-01

    Conditions have been developed for the comproportionation reaction of Cu2+ and copper metal to prepare aqueous solutions of Cu+ that are stabilized from disproportionation by MeCN and other Cu+-stabilizing ligands. These solutions were then used in ITC measurements to quantify the thermodynamics of formation of a set of Cu+ complexes (CuI(MeCN)3+, CuIMe6Trien+, CuI(BCA)23−, CuI(BCS)23−), which have stabilities ranging over 15 orders of magnitude, for their use in binding and calorimetric measurements of Cu+ interaction with proteins and other biological macromolecules. These complexes were then used to determine the stability and thermodynamics of formation of a 1 : 1 complex of Cu+ with the biologically important tri-peptide glutathione, GSH. These results identify Me6Trien as an attractive Cu+-stabilizing ligand for calorimetric experiments, and suggest that caution should be used with MeCN to stabilize Cu+ due to its potential for participating in unquantifiable ternary interactions. PMID:26327397

  13. Thermodynamic properties by non-calorimetric methods. Progress report, August 1, 1988--July 31, 1989

    SciTech Connect

    Steele, W.V.; Chirico, R.D.; Collier, W.B.; Strube, M.M. |

    1989-12-31

    This three year research program provides a valuable complement to the experimental programs currently in progress at NIPER for the Advanced Research and Technology Development (AR and TD) and Advanced Exploration and Process Technology (AEPT) divisions of the Department of Energy. These experimental programs are focused on the calorimetric determination of thermodynamic properties of key polynuclear heteroatom-containing aromatic molecules. This project for the Office of Energy Research focuses on the non-calorimetric determination of thermodynamic properties through the extension of existing correlation methodologies and through molecular spectroscopy with statistical mechanics. The paper discusses progress in three areas: (1) Improvement of thermochemical and thermophysical property predictions via enhancement of group-contribution methods using two approaches, namely, development and improvement of group-contribution parameters via correlations involving the expanded modern thermodynamics data base and development of group-contribution parameters via molecular spectroscopy and statistical mechanics of key monocyclic organic compounds; (2) Molecular spectroscopy and statistical mechanics: equipment development and developments in interpretation and assignment of spectra; and (3) Thermophysical property correlations.

  14. ESTIMATION OF BARE-SOIL EVAPORATION USING A CALORIMETRIC APPROACH WITH HEAT FLUX MEASURED AT MULTIPLE DEPTHS

    Technology Transfer Automated Retrieval System (TEKTRAN)

    An assumption in calorimetric methods for soil heat flux is that sensible heat terms can be balanced (i.e., if the heat flux is known at one depth, the heat flux at another depth may be determined by monitoring the change in heat storage). Latent heat from water evaporation is assigned to the energy...

  15. Emittance characterization of thermal control paints, coatings and surfaces using a calorimetric technique

    NASA Technical Reports Server (NTRS)

    Jaworske, Donald A.

    1994-01-01

    Thermal control surfaces are used in every spacecraft thermal management system to dissipate heat through radiant heat transfer. This paper describes the thermal performance of several thermal control paints, coatings, and surfaces, as characterized by a calorimetric vacuum emissometer. The emissometer is designed to measure the functional emittance of a surface based on heat transfer from an underlying substrate to the surface and from the surface or near surface to a surrounding cold wall. Emittance measurements were made between 200 and 350 K. Polished aluminum, used here as a standard, was found to have a total hemispherical emittance of 0.06, as expected. A velvet black paint, also used here as a standard, was found to have an emittance of 0.94 at room temperature. Other surfaces of interest included a polyurethane-based black paint designated Z-306, a highly polished 316L stainless steel, and an atomic oxygen beam-textured carbon-carbon composite.

  16. Molecular mobility and relaxation process of isolated lignin studied by multifrequency calorimetric experiments.

    PubMed

    Guigo, Nathanael; Mija, Alice; Vincent, Luc; Sbirrazzuoli, Nicolas

    2009-02-28

    The glass transition of lignin has been studied by multifrequency calorimetric measurements in order to highlight the morphological changes and the dynamic aspects associated to this relaxation process. Influences of water sorption and thermal annealing on molecular mobility have been considered. Additional investigations by thermogravimetry, infra-red spectroscopy and rheometry have been performed to corroborate the claims. The relaxation process of annealed lignin shows a different behaviour as the consequence of micro-structural modifications of lignin. These are explained by redistribution of secondary bonds as well as formation of new interunit linkages. Concerning the dynamic aspects, apparent activation energy, E, and sizes of cooperatively rearranging region, V(crr), have been evaluated respectively from the frequency dependence and heat capacity measurements of the glass transition. Compared to dried lignin, both E and V(crr) significantly decrease in a water-sorbed matrix indicating that the three-dimensional structure presents a higher mobility and is less confined. PMID:19209367

  17. Biodegradable composites filled with halloysite nanonotubes: Calorimetric investigations and structural issues

    NASA Astrophysics Data System (ADS)

    Russo, Pietro; Vetrano, Barbara; Acierno, Domenico

    2012-07-01

    Halloysite nanotubes were dispersed in a commercially biodegradable blends by melt compounding. Bionanocomposites based on a film-grade commercial blend of poly(hydroxybutirate)-co-valerate PHBV and poly(butylene adipate-co-therephthalate) PBAT and containg up to 10% by weigth of tubular clays (HNTs) were prepared by using a twin-screw lab extruder and filmed by a film-blowing equipment. Film samples were subjected to thermal and structural investigations. Calorimetric analysis showed that signals shape is clearly affected by the heating and cooling rate, respectively. Structural investigations performed by X-Ray diffraction tests satisfactorily allowed to interpret thermal behavior highlighting the occurrence of different crystalline modifications, depending on the scanning thermal rate, the inclusion of filler and its chemical functionalization.

  18. A calorimetric study on interactions of colchicine with human serum albumin

    NASA Astrophysics Data System (ADS)

    Zhao, Qiang; Xu, Xiang-Yu; Sun, Xiang-Jun; Liu, Min; Sun, De-Zhi; Li, Lin-Wei

    2009-08-01

    Interaction of colchicine (COL) with human serum albumin (HSA) in buffer solutions (pH 7.2) has been investigated by isothermal titration calorimetry (ITC) combined with circular dichroism (CD) and UV-vis spectra. Heats of the interactions have been determined at 298.15 K. Based on the calorimetric data and reasonable suppositions for the bio-macromolecule - ligand binding process, the equilibrium constants, standard changes of enthalpy, entropy and Gibbs free energy of the processes are obtained. The results show that there are two classes of ligand binding sites. The first-class binding is mainly driven by entropy, while the second-class binding is synergistically driven by entropy and enthalpy. Circular dichroism (CD) and UV-vis spectra show that COL can change the secondary structure of HSA molecule.

  19. Calorimetric study on the effect of 60Co γ-rays on the growth of microorganisms

    NASA Astrophysics Data System (ADS)

    Wirkner, Sandra; Takahashi, Katsutada; Furuta, Masakazu; Hayashi, Toshio

    2002-03-01

    Using a calorimeter equipped with 24 sample units, the heat evolution from growing Saccharomyces cerevisiae, Escherichia coli and spores of Bacillus pumilus and Bacillus stearothermophilus was detected in the form of growth thermograms. Irradiation with 60Co γ-rays affected the growth pattern, which was used for a quantitative analysis of the effect on microorganisms. Irradiation of B. pumilus and B. stearothermophilus spores led to dose-dependent delays in growth, indicating a bactericidal effect. In case of 60Co γ-irradiated S. cerevisiae, a dose-dependent reduction of the growth rate constant was observed together with the retardation in growth, indicating a combination of bactericidal and bacteriostatic effects. An equation to determine the number of survivors on the basis of the retardation in growth tα and the growth rate constant μ was developed, which proved the opportunity to use the calorimetric technique in predictive microbiology.

  20. AC loss measurement of superconducting dipole magnets by the calorimetric method

    SciTech Connect

    Morita, Y.; Hara, K.; Higashi, N.; Kabe, A.

    1996-12-31

    AC losses of superconducting dipole magnets were measured by the calorimetric method. The magnets were model dipole magnets designed for the SSC. These were fabricated at KEK with 50-mm aperture and 1.3-m overall length. The magnet was set in a helium cryostat and cooled down to 1.8 K with 130 L of pressurized superfluid helium. Heat dissipated by the magnet during ramp cycles was measured by temperature rise of the superfluid helium. Heat leakage into the helium cryostat was 1.6 W and was subtracted from the measured heat to obtain AC loss of the magnet. An electrical measurement was carried out for calibration. Results of the two methods agreed within the experimental accuracy. The authors present the helium cryostat and measurement system in detail, and discuss the results of AC loss measurement.

  1. Total hemispherical emittance measured at high temperatures by the calorimetric method

    NASA Technical Reports Server (NTRS)

    Difilippo, Frank; Mirtich, Michael J.; Banks, Bruce A.; Stidham, Curtis; Kussmaul, Michael

    1989-01-01

    A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements (plus or minus 5 percent). The probable error of the CVE measurements was typically less than 1 percent.

  2. Calorimetric determination of thermal parameters for the Li/BrCl in SOCl2 (BCX) chemistry

    NASA Technical Reports Server (NTRS)

    Darcy, Eric C.; Kalu, Eric E.; White, Ralph E.

    1990-01-01

    The heat capacity of a Li-BCX DD-cell was found to be dependent on its state of charge by drop calorimetry measurements. The method of drop calorimetry involves measuring the energy (joules) gained or lost from a sample that is transferred from a bath at temperature A to one at temperature B. The thermoneutral potential is defined as the cell potential where the cell electrochemical reactions are neither exothermic nor endothermic. A Hart scientific calorimeter system, Model No. S77XX, designed for heat conduction calorimetry and drop calorimetry was used. Calorimetric analysis yielded a thermoneutral potential of 4.14 volts and a cell heat capacity dependent on the state of charge.

  3. Direct calorimetric verification of thermodynamic instability of lead halide hybrid perovskites.

    PubMed

    Nagabhushana, G P; Shivaramaiah, Radha; Navrotsky, Alexandra

    2016-07-12

    Hybrid perovskites, especially methylammonium lead iodide (MAPbI3), exhibit excellent solar power conversion efficiencies. However, their application is plagued by poor chemical and structural stability. Using direct calorimetric measurement of heats of formation, MAPbI3 is shown to be thermodynamically unstable with respect to decomposition to lead iodide and methylammonium iodide, even in the absence of ambient air or light or heat-induced defects, thus limiting its long-term use in devices. The formation enthalpy from binary halide components becomes less favorable in the order MAPbCl3, MAPbBr3, MAPbI3, with only the chloride having a negative heat of formation. Optimizing the geometric match of constituents as measured by the Goldschmidt tolerance factor provides a potentially quantifiable thermodynamic guide for seeking chemical substitutions to enhance stability. PMID:27357677

  4. Total hemispherical emittance measured at high temperatures by the calorimetric method

    SciTech Connect

    DiFilippo, F.; Mirtich, M.J.; Banks, B.A.; Stidham, C.; Kussmaul, M.

    1994-09-01

    A calorimetric vacuum emissometer (CVE) capable of measuring total hemispherical emittance of surfaces at elevated temperatures was designed, built, and tested. Several materials with a wide range of emittances were measured in the CVE between 773 to 923 K. These results were compared to values calculated from spectral emittance curves measured in a room temperature Hohlraum reflectometer and in an open-air elevated temperature emissometer. The results differed by as much as 0.2 for some materials but were in closer agreement for the more highly-emitting, diffuse-reflecting samples. The differences were attributed to temperature, atmospheric, and directional effects, and errors in the Hohlraum and emissometer measurements ({+-} 5 percent). The probable error of the CVE measurements was typically less than 1 percent.

  5. Calorimetric approach for 3D dosimetry of high intensity therapeutic electron beams

    NASA Astrophysics Data System (ADS)

    Lamanna, E.; Fiorillo, A. S.; Vena, R.; Berdondini, A.; Bettuzzi, M.; Brancaccio, R.; Casali, F.; Morigi, M. P.; Bilokon, H.; Barca, G.; Castrovillari, F.; Siaka, Y. F. T.

    2009-12-01

    The technique of High Dose Rate Intra-Operative Radiation Therapy (HDR-IORT) consists in the delivery of irradiation immediately after the removal of a cancerous mass, where the same incision is used to focalize the radiation to the tumour bed. Given its particular characteristics, IORT requires dose measurements that are different from those requested in external radiotherapy treatments. The main reason lies in the fact that in this case a single high dose must be delivered to a target volume whose extension and depth will be determined directly during the operation. Because of this peculiar characteristics, until now there is not a dosimetric system able to detect the electron beam giving at once a realtime response and an extensive spatial measure of the absorbed dose. Within the framework of a research project of the INFN (Italian National Institute of Nuclear Physics), we proposed a new system to overcome the problems, Dosiort. The final set-up is a solid phantom having a density approximately 1 g/cm3 with sensitive layers of scintillating fibres at fixed positions in a calorimetric configuration for the containment of electrons of energy 4-12 MeV. The prototype will be able to define the physical and geometrical characteristics of the electron beam (energy, isotropy, homogeneity, etc) and to measure the parameters needed to select the energy, the intensity and the Monitor Units (MU) for the exposition: percentage Depth Dose; beam profiles; isodose curves; values of dose per MU. In this work we present the results obtained by using two orthogonal layers of the calorimetric phantom Dosiort, in particular we report the measurement of the dynamic range of the read-out system and the first qualitative study of the results which can be extracted from the measurements taken in a test beam.

  6. Kyste hydatique primitif du sein

    PubMed Central

    Mouslik, Rabii; Settaf, Abdellatif; Elalami, Yacir; Lahnini, Hicham; Lahlou, Khalid; Chad, Bouziane

    2012-01-01

    Le kyste hydatique du sein est une parasitose rare même dans les pays endémiques. Nous rapportons une nouvelle observation d'une patiente de 30 ans qui présentait une masse du sein gauche. Le diagnostic de kyste hydatique du sein a été évoqué devant les données de l'examen clinique et de la mammographie couplée à l’échographie. Le geste chirurgical a consisté en une kystectomie. L'examen anatomopathologique de la pièce opératoire a confirmé le diagnostic. PMID:23133704

  7. Calorimetric output power measurements on a CW 20 kW 7.16 GHz microwave transmitter

    NASA Technical Reports Server (NTRS)

    Perez, Raul M.; Conroy, Bruce L.

    1991-01-01

    A calorimetric measurement technique developed for NASA's Deep Space Network (DSN) transmitters that does not require data on the coolant's thermal parameters is described. Calibration of the measurement system is achieved by measuring the DC input power to the klystron and relating coolant temperature increases to this known power dissipation. Agreement between calorimetric and electrical measurements of total system power was good, the difference being less than 2 percent. The operation of the system was not greatly affected by the composition of the coolant, which was varied from pure water to 40 percent ethylene glycol by mass. Good accuracy was also shown at output power levels, which varied over a 3.6:1 range.

  8. Differential scanning calorimetric evaluation of human meibomian gland secretions and model lipid mixtures: transition temperatures and cooperativity of melting

    PubMed Central

    Lu, Hua; Wojtowicz, Jadwiga C.; Butovich, Igor A.

    2013-01-01

    Meibomian gland secretions (or meibum) are produced by holocrine meibomian glands and are secreted in melted form onto the ocular surface of humans and animals to form a protective tear film lipid layer (TFLL). Its protective effect strongly depends on the composition and, hence, thermotropic behavior of meibum. The goal of our study was to quantitatively evaluate the melting characteristics of human meibum and model lipid mixtures using differential scanning microcalorimetry. Standard calorimetric parameters, e.g. changes in calorimetric enthalpy, transition temperatures T(m), cooperativity of melting etc. were assessed. We found that thermotropic behavior of meibum resembled that of relatively simple mixtures of unsaturated wax esters, but showed a lower change in calorimetric enthalpy, which can be indicative of a looser packing of lipids in meibum compared with pure standards and their simple mixtures. The cooperativity of melting of meibomian lipids was comparable to that of an equimolar mixture of four oleic-acid based wax esters. We demonstrated that the phase transitions in meibum start at about 10 to 15 °C and end at 35-36 °C, with T(m) being about 30 °C. The highly asymmetrical shape of the thermotropic peak of meibum is important for the physiology and biophysics of TFLL. PMID:23578711

  9. Electron energy and charge albedos - calorimetric measurement vs Monte Carlo theory

    SciTech Connect

    Lockwood, G.J.; Ruggles, L.E.; Miller, G.H.; Halbleib, J.A.

    1981-11-01

    A new calorimetric method has been employed to obtain saturated electron energy albedos for Be, C, Al, Ti, Mo, Ta, U, and UO/sub 2/ over the range of incident energies from 0.1 to 1.0 MeV. The technique was so designed to permit the simultaneous measurement of saturated charge albedos. In the cases of C, Al, Ta, and U the measurements were extended down to about 0.025 MeV. The angle of incidence was varied from 0/sup 0/ (normal) to 75/sup 0/ in steps of 15/sup 0/, with selected measurements at 82.5/sup 0/ in Be and C. In each case, state-of-the-art predictions were obtained from a Monte Carlo model. The generally good agreement between theory and experiment over this extensive parameter space represents a strong validation of both the theoretical model and the new experimental method. Nevertheless, certain discrepancies at low incident energies, especially in high-atomic-number materials, and at all energies in the case of the U energy albedos are not completely understood.

  10. Algorithms for Identification of Nearly-Coincident Events in Calorimetric Sensors

    NASA Astrophysics Data System (ADS)

    Alpert, B.; Ferri, E.; Bennett, D.; Faverzani, M.; Fowler, J.; Giachero, A.; Hays-Wehle, J.; Maino, M.; Nucciotti, A.; Puiu, A.; Swetz, D.; Ullom, J.

    2015-12-01

    For experiments with high arrival rates, reliable identification of nearly-coincident events can be crucial. For calorimetric measurements to directly measure the neutrino mass such as HOLMES, unidentified pulse pile-ups are expected to be a leading source of experimental error. Although Wiener filtering can be used to recognize pile-up, it suffers from errors due to pulse shape variation from detector nonlinearity, readout dependence on subsample arrival times, and stability issues from the ill-posed deconvolution problem of recovering Dirac delta-functions from smooth data. Due to these factors, we have developed a processing method that exploits singular value decomposition to (1) separate single-pulse records from piled-up records in training data and (2) construct a model of single-pulse records that accounts for varying pulse shape with amplitude, arrival time, and baseline level, suitable for detecting nearly-coincident events. We show that the resulting processing advances can reduce the required performance specifications of the detectors and readout system or, equivalently, enable larger sensor arrays and better constraints on the neutrino mass.

  11. The CALorimetric Electron Telescope (CALET) for high-energy astroparticle physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asano, K.; Asaoka, Y.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bonechi, S.; Bongi, M.; Buckley, J. H.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hareyama, M.; Hasebe, N.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Kataoka, J.; Kataoka, R.; Katayose, Y.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Motz, H. M.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S. B.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2015-08-01

    The CALorimetric Electron Telescope (CALET) is a space experiment, currently under development by Japan in collaboration with Italy and the United States, which will measure the flux of cosmic-ray electrons (and positrons) up to 20 TeV energy, of gamma rays up to 10 TeV, of nuclei with Z from 1 to 40 up to 1 PeV energy, and will detect gamma-ray bursts in the 7 keV to 20 MeV energy range during a 5 year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of CALET, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fibre planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch (expected in 2015) to the International Space Station ISS, for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  12. The CALorimetric Electron Telescope (CALET) for high-energy astroparticle physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asano, K.; Asaoka, Y.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bonechi, S.; Bongi, M.; Buckley, J. H.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hareyama, M.; Hasebe, N.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Kataoka, J.; Kataoka, R.; Katayose, Y.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Motz, H. M.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S. B.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2015-05-01

    The CALorimetric Electron Telescope (CALET) is a space experiment, currently under development by Japan in collaboration with Italy and the United States, which will measure the flux of cosmic-ray electrons (and positrons) up to 20 TeV energy, of gamma rays up to 10 TeV, of nuclei with Z from 1 to 40 up to 1 PeV energy, and will detect gamma-ray bursts in the 7 keV to 20 MeV energy range during a 5 year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of CALET, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fibre planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch (expected in 2015) to the International Space Station ISS, for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  13. Calorimetric method for adjusting the mass of culture fluid in a bioreactor

    NASA Astrophysics Data System (ADS)

    Kotelnikov, G. V.; Moiseyeva, S. P.; Krayev, V. P.

    1998-05-01

    A new calorimetric method for adjusting the mass of culture fluid in a bioreactor and the results of its experimental testing are described. The method is based on constant heat capacity of liquids in the presence of disturbing factors accompanying biotechnology processes. A new measuring parameter independent of thermal noise induced by the stirrer, the flow of fluids, chemical and physical interactions of substances in the bioreactor was used for adjusting the mass of culture fluid. This parameter is Ph, the power increment in the heater under steady-state conditions of heating the bioreactor. The scanning calorimetry principle was used to make the measurements. It was shown that it is necessary to provide a constant heating rate V for the bioreactor and a high-speed response of the automated control system (ACS) for bioreactor temperature. The ACS developed on the base of the dynamic error and transient response h(t) calculated by the inverse Laplace transform with the use of the closed-loop transfer function gives V=const and the control time of about several seconds. The experimental data reported show the adjustment of the mass of culture fluid in a 3 l bioreactor with an error of no more than 10 g. This enables an accurate evaluation of the biomass amount in the bioreactor, specific growth rate, and other growth parameters determined using specific growth rate.

  14. First calorimetric determination of heat of extraction of 248Cm in a bi-phasic system

    SciTech Connect

    Leigh R. Martin; Peter R. Zalupski

    2011-06-01

    This report presents a summary of the work performed to meet FCR&D level 2 milestone M21SW050201, 'Complete the first calorimetric determination of heat of extraction of 248Cm in a bi-phasic system'. This work was carried out under the auspices of the Thermodynamics and Kinetics FCR&D work package. To complement previous work undertaken under this work package we have extended out heat of extraction studies by di-2-ethyl-hexyl-phosphoric acid to curium. This report also details the heat of extraction of samarium in the same system. This work was performed to not only test the methodology but also to check for consistency with the heats of extraction obtained with those in the prior literature. The heat of extraction for samarium that was obtained in this study was -9.6 kJ mol-1, which is in reasonable agreement with the previously obtained value of -10.9 kJ mol-1. The curium heat of extraction was performed under two sets of conditions and the obtained heats of extraction were in reasonable agreement with each other at -16.0 {+-} 1.1 and -16.8 {+-} 1.5 kJ mol-1.

  15. A calorimetric study of the hydrolysis and peroxide complex formation of the uranyl(VI) ion.

    PubMed

    Zanonato, Pier Luigi; Di Bernardo, Plinio; Grenthe, Ingmar

    2014-02-14

    The enthalpies of reaction for the formation of uranyl(vi) hydroxide {[(UO2)2(OH)2](2+), [(UO2)3(OH)4](2+), [(UO2)3(OH)5](+), [(UO2)3(OH)6](aq), [(UO2)3(OH)7](-), [(UO2)3(OH)8](2-), [(UO2)(OH)3](-), [(UO2)(OH)4](2-)} and peroxide complexes {[UO2(O2)(OH)](-) and [(UO2)2(O2)2(OH)](-)} have been determined from calorimetric titrations at 25 °C in a 0.100 M tetramethyl ammonium nitrate ionic medium. The hydroxide data have been used to test the consistency of the extensive thermodynamic database published by the Nuclear Energy Agency (I. Grenthe, J. Fuger, R. J. M. Konings, R. J. Lemire, A. B. Mueller, C. Nguyen-Trung and H. Wanner, Chemical Thermodynamics of Uranium, North-Holland, Amsterdam, 1992 and R. Guillaumont, T. Fanghänel, J. Fuger, I. Grenthe, V. Neck, D. J. Palmer and M. R. Rand, Update on the Chemical Thermodynamics of Uranium, Neptunium, Plutonium, Americium and Technetium, Elsevier, Amsterdam, 2003). A brief discussion is given about a possible structural relationship between the trinuclear complexes [(UO2)3(OH)n](6-n), n = 4-8. PMID:24301256

  16. Optical and Calorimetric Studies of Cholesterol-Rich Filamentous, Helical Ribbon and Crystal Microstructures

    SciTech Connect

    Miroshnikova, Y. A.; Elsenbeck, M.; Zastavker, Y. V.; Kashuri, K; Iannacchione, G. S.

    2009-04-19

    Formation of biological self-assemblies at all scales is a focus of studies in fields ranging from biology to physics to biomimetics. Understanding the physico-chemical properties of these self-assemblies may lead to the design of bio-inspired structures and technological applications. Here we examine self-assembled filamentous, helical ribbon, and crystal microstructures formed in chemically defined lipid concentrate (CDLC), a model system for cholesterol crystallization in gallbladder bile. CDLC consists of cholesterol, bilayer-forming amphiphiles, micelle-forming amphiphiles, and water. Phase contrast and differential interference contrast (DIC) microscopy indicate the presence of three microstructure types in all samples studied, and allow for an investigation of the structures' unique geometries. Additionally, confocal microscopy is used for qualitative assessment of surface and internal composition. To complement optical observations, calorimetric (differential-scanning and modulation) experiments, provide the basis for an in-depth understanding of collective and individual thermal behavior. Observed ''transition'' features indicate clustering and ''straightening'' of helical ribbons into short, increasingly thickening, filaments that dissolve with increasing temperature. These results suggest that all microstructures formed in CDLC may coexist in a metastable chemical equilibrium. Further investigation of the CDLC thermal profile should uncover the process of cholesterol crystallization as well as the unique design and function of microstructures formed in this system.

  17. Calorimetric studies of the ammonia-water system with application to the outer solar system

    NASA Astrophysics Data System (ADS)

    Yarger, J.; Lunine, J. I.; Burke, M.

    1993-07-01

    A series of heating experiments was performed on the condensed ammonia-water system using a differential scanning calorimeter (DSC). The water-rich samples were cooled quickly to below 130 K, then heated at a variety of rates. Rather than a single peritectic melt at 176 K, expected for the equilibrium system of water ice and ammonia dihydrate, four enthalpic transitions were repeatedly seen in the temperature range 150-176 K. These transitions are generally consistent with the earlier calorimetric results of Van Kasteren (1973), who interpreted the lowest temperature exotherm as crystallization of an amorphous ammonia-water compound formed during cooling. We propose that both sets of experiments are seeing the crystallization of ammonia monohydrate, which is metastable relative to the dihydrate, followed by partial remelting and crystallization of dihydrate upon further heating. The apparent stability of the monohydrate in the dihydrate equilibrium field implies a potentially complex behavior of ammonia-water ices in satellites. Possible self-heating of the mixture by several tens of degrees up to the 170 K eutectic could make mobilization of ammonia-water liquids in icy satellite interiors energetically easier than previously thought.

  18. Calorimetric measurement of electron energy deposition in extended media. Theory vs experiment

    SciTech Connect

    Lockwood, G.J.; Ruggles, L.E.; Miller, G.H.; Halbleib, J.A.

    1980-01-01

    A new calorimetric technique has been developed for measuring electron energy deposition profiles in one dimension. The experimental procedures and theoretical analyses required in the application of the new method are reviewed. Extensive results are presented for electron energy deposition profiles in semi-infinite homogeneous and multilayer configurations. These data cover a range of elements from beryllium through uranium at source energies from 0.3 to 1.0 MeV (selected data at 0.5 and 0.1 MeV) and at incident angles from 0/sup 0/ to 60/sup 0/. In every case, the experimental profiles are compared with the predictions of a coupled electron/photon Monte Carlo transport code. Overall agreement between theory and experiment is very good. However, there appears to be a tendency for the theoretical profiles to be higher near the peaks and lower near the tails, especially in high-Z materials. There is also a discrepancy between theory and experiment in low-Z materials near high-Z/low-Z interfaces.

  19. Thermodynamic model for calorimetric and phase coexistence properties of coal derived fluids

    SciTech Connect

    Kabadi, V.N.

    1990-01-01

    A model for phase equilibria of coal derived liquids is to be extended to include calorimetric properties as well. To accomplish this satisfactorily, the proposed work includes three tasks: (1) Refinement of the characterization procedure to include distribution of sulfur, oxygen, and nitrogen heteroatoms in coal liquids; (2) Measurement of high temperature (up to 400{degrees}C) and high pressure (up to 1000 psi) VLE data for binary systems of selected model compounds; and (3) Development of the thermodynamic model. The final product will include a computer program which with measurable properties of coal liquids as input, will give results for phase coexistence properties and excess enthalpies in the liquid phase. Efforts are continuing to apply the new thermodynamic model for VLE and enthalpy predictions for coal liquids by the methods of continuous thermodynamics. Recently, Thompson, Brobst and Hankinson have developed an equation of state that represents compressibilities of liquids very well. The authors have undertaken the task of combining this equation of state with their thermodynamic model to provide a comprehensive model for high pressure liquid mixtures. Calibration and preliminary set-up procedure for the VLE apparatus with the new liquid level sensor have been completed. The apparatus is currently being tested with the binary system quinoline-tetralin. Chromatographic characterization work was delayed because of complexities of the calibration procedure and tedious calculations necessary for number average and weight average molecular weights. Results on the chromatographic studies are being deferred until computer software is received.

  20. The Calorimetric Electron Telescope (CALET) for High Energy Astroparticle Physics on the International Space Station

    NASA Astrophysics Data System (ADS)

    Torii, Shoji

    The Calorimetric Electron Telescope, CALET, space experiment, currently under development by Japan in collaboration with Italy and the United States, will measure the flux of Cosmic Ray electrons (and positrons) t o 20 TeV, gamma rays to 10 TeV , nuclei with Z=1 to 40 up to 1,000 TeV, and Gamma-ray bursts in the 7 keV- 10 MeV energy range during a five year mission. These measurements are essential to investigate possible nearby astrophysical sources of high energy electrons, study the details of galactic particle propagation and search for dark matter signatures. The main detector of Calet, the Calorimeter, consists of a module to identify the particle charge, followed by a thin imaging calorimeter (3 radiation lengths) with tungsten plates interleaving scintillating fiber planes, and a thick energy measuring calorimeter (27 radiation lengths) composed of lead tungstate logs. The Calorimeter has the depth, imaging capabilities and energy resolution necessary for excellent separation between hadrons, electrons and gamma rays. The instrument is currently being prepared for launch, during the Japan Fiscal Year (April, 2014- March, 2015) time frame, to the International Space Station (ISS) for installation on the Japanese Experiment Module - Exposure Facility (JEM-EF).

  1. Status and performance of the CALorimetric Electron Telescope (CALET) on the International Space Station

    NASA Astrophysics Data System (ADS)

    Adriani, O.; Akaike, Y.; Asaoka, Y.; Asano, K.; Bagliesi, M. G.; Bigongiari, G.; Binns, W. R.; Bongi, M.; Buckley, J. H.; Cassese, A.; Castellini, G.; Cherry, M. L.; Collazuol, G.; Ebisawa, K.; Di Felice, V.; Fuke, H.; Guzik, T. G.; Hams, T.; Hasebe, N.; Hareyama, M.; Hibino, K.; Ichimura, M.; Ioka, K.; Israel, M. H.; Javaid, A.; Kamioka, E.; Kasahara, K.; Katayose, Y.; Kataoka, J.; Kataoka, R.; Kawanaka, N.; Kitamura, H.; Kotani, T.; Krawczynski, H. S.; Krizmanic, J. F.; Kubota, A.; Kuramata, S.; Lomtadze, T.; Maestro, P.; Marcelli, L.; Marrocchesi, P. S.; Mitchell, J. W.; Miyake, S.; Mizutani, K.; Motz, H. M.; Moiseev, A. A.; Mori, K.; Mori, M.; Mori, N.; Munakata, K.; Murakami, H.; Nakagawa, Y. E.; Nakahira, S.; Nishimura, J.; Okuno, S.; Ormes, J. F.; Ozawa, S.; Palma, F.; Papini, P.; Rauch, B. F.; Ricciarini, S.; Sakamoto, T.; Sasaki, M.; Shibata, M.; Shimizu, Y.; Shiomi, A.; Sparvoli, R.; Spillantini, P.; Takahashi, I.; Takayanagi, M.; Takita, M.; Tamura, T.; Tateyama, N.; Terasawa, T.; Tomida, H.; Torii, S.; Tunesada, Y.; Uchihori, Y.; Ueno, S.; Vannuccini, E.; Wefel, J. P.; Yamaoka, K.; Yanagita, S.; Yoshida, A.; Yoshida, K.; Yuda, T.

    2014-11-01

    The CALorimetric Electron Telescope (CALET) space experiment, currently under development by Japan in collaboration with Italy and the United States, will measure the flux of cosmic-ray electrons (including positrons) to 20 TeV, gamma rays to 10 TeV and nuclei with Z=1 to 40 up to 1,000 TeV during a two-year mission on the International Space Station (ISS), extendable to five years. These measurements are essential to search for dark matter signatures, investigate the mechanism of cosmic-ray acceleration and propagation in the Galaxy and discover possible astrophysical sources of high-energy electrons nearby the Earth. The instrument consists of two layers of segmented plastic scintillators for the cosmic-ray charge identification (CHD), a 3 radiation length thick tungsten-scintillating fiber imaging calorimeter (IMC) and a 27 radiation length thick lead-tungstate calorimeter (TASC). CALET has sufficient depth, imaging capabilities and excellent energy resolution to allow for a clear separation between hadrons and electrons and between charged particles and gamma rays. The instrument will be launched to the ISS within 2014 Japanese Fiscal Year (by the end of March 2015) and installed on the Japanese Experiment Module-Exposed Facility (JEM-EF). In this paper, we will review the status and main science goals of the mission and describe the instrument configuration and performance.

  2. Calorimetric studies of the ammonia-water system with application to the outer solar system

    NASA Technical Reports Server (NTRS)

    Yarger, Jeffery; Lunine, Jonathan I.; Burke, Michael

    1993-01-01

    A series of heating experiments was performed on the condensed ammonia-water system using a differential scanning calorimeter (DSC). The water-rich samples were cooled quickly to below 130 K, then heated at a variety of rates. Rather than a single peritectic melt at 176 K, expected for the equilibrium system of water ice and ammonia dihydrate, four enthalpic transitions were repeatedly seen in the temperature range 150-176 K. These transitions are generally consistent with the earlier calorimetric results of Van Kasteren (1973), who interpreted the lowest temperature exotherm as crystallization of an amorphous ammonia-water compound formed during cooling. We propose that both sets of experiments are seeing the crystallization of ammonia monohydrate, which is metastable relative to the dihydrate, followed by partial remelting and crystallization of dihydrate upon further heating. The apparent stability of the monohydrate in the dihydrate equilibrium field implies a potentially complex behavior of ammonia-water ices in satellites. Possible self-heating of the mixture by several tens of degrees up to the 170 K eutectic could make mobilization of ammonia-water liquids in icy satellite interiors energetically easier than previously thought.

  3. Effect of sulfoxides on the thermal denaturation of hen lysozyme: A calorimetric and Raman study

    NASA Astrophysics Data System (ADS)

    Torreggiani, A.; Di Foggia, M.; Manco, I.; De Maio, A.; Markarian, S. A.; Bonora, S.

    2008-11-01

    A multidisciplinary study of the thermal denaturation of lysozyme in the presence of three sulfoxides with different length in hydrocarbon chain (DMSO, DESO, and DPSO) was carried out by means of DSC, Raman spectroscopy, and SDS-PAGE techniques. In particular, the Td and Δ H values obtained from the calorimetric measurements showed that lysozyme is partially unfolded by sulfoxides but most of the conformation holds native state. The sulfoxide denaturing ability increases in the order DPSO > DESO > DMSO. Moreover, only DMSO and DESO have a real effect in preventing the heat-induced inactivation of the protein and their maximum heat-protective ability is reached when the DMSO and DESO amount is ⩾25% w/w. The sulfoxide ability to act as effective protective agents against the heat-induced inactivation was confirmed by the protein analysis. The enzymatic activity, as well as the SDS-PAGE analysis, suggested that DESO, having a low hydrophobic character and a great ability to stabilise the three-dimensional water structure, is the most heat-protective sulfoxide. An accurate evaluation of the heat-induced conformational changes of the lysozyme structure before and after sulfoxide addition was obtained by the analysis of the Raman spectra. The addition of DMSO or DESO in low concentration resulted to sensitively decrease the heat-induced structural modifications of the protein.

  4. Characterization of commercial Li-ion batteries using electrochemical-calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Al Hallaj, S.; Prakash, J.; Selman, J. R.

    Commercial Li-ion cells of Type 18650 dimensions and prismatic designs from different manufacturers have been tested to evaluate their performance and to study their thermal behavior using electrochemical-calorimetric methods. All cells tested in this work showed good performance and cyclability under normal operating conditions. The measured heat effect for the cells were exothermic during discharge and partially endothermic during charge. Cell impedance was measured for selected cells and showed some dependence on the state of charge or depth of discharge, with significant increase at the end of discharge due to concentration polarization. The entropy coefficient (d Eeq/d T) for the A&T (18650) and Panasonic (CGR 18650) cells were measured using potentiometric methods at different depths of discharge (DOD). The measured values for both cells showed some dependence on the DOD with some perturbation near 4.0 V, where the measured d Eeq/d T for Panasonic cell had an unexpected positive value. This was found to be consistent with the measured endothermic heat effect during discharge for the Panasonic cell near Eeq=4.0 V. This may be related to a phase change in the LiCoO 2 cathode material, as reported in the literature, and to structural transformation in the graphite used as anode material, in the Panasonic cell.

  5. Calorimetric and theoretical study of the interaction between some saccharides and sodium halide in water.

    PubMed

    Zhuo, Kelei; Fu, Yingyi; Bai, Guangyue; Wang, Jianji; Yan, Haike; Wang, Hanqing

    2012-08-23

    Dilution enthalpies and mixing enthalpies of sodium halide and some saccharides (glucose, galactose, xylose, arabinose, fructose, and sucrose) in aqueous solution were determined by calorimetric measurements at 298.15 K. The values were used to determine enthalpic pair interaction parameters. Combined with Gibbs energy pair parameters, entropic pair interaction parameters were also obtained. Theoretical calculations at the B3LYP/6-311++G(d,p) level were carried out to provide the information of structures and thermodynamic functions. The information reveals the thermodynamic essence of the interactions between sodium halide and saccharides in aqueous solutions. The experimental results and theoretical calculations show that the sign of enthalpic pair interaction parameter 2υh(ES) is determined by the direct interaction between saccharides and ions, whereas the difference in value of 2υh(ES) for different saccharides or electrolytes depends on the partial dehydration of saccharides or anions in aqueous solution. The difference in value of entropic pair interaction parameters depends partly on the different dominant interactions in the process of partial dehydration of saccharides or ions. An enthalpy-entropy compensation relationship was observed for the sodium bromide-aldopyranose-water systems. Remarkably, it can be conjectured that the hydration entropy of glucose is lower than for other monosaccharides. Perhaps it is one of the reasons why glucose plays an important role in living organisms rather than other monosaccharides. PMID:22779908

  6. Algorithms for Identification of Nearly-Coincident Events in Calorimetric Sensors

    NASA Astrophysics Data System (ADS)

    Alpert, B.; Ferri, E.; Bennett, D.; Faverzani, M.; Fowler, J.; Giachero, A.; Hays-Wehle, J.; Maino, M.; Nucciotti, A.; Puiu, A.; Swetz, D.; Ullom, J.

    2016-07-01

    For experiments with high arrival rates, reliable identification of nearly-coincident events can be crucial. For calorimetric measurements to directly measure the neutrino mass such as HOLMES, unidentified pulse pile-ups are expected to be a leading source of experimental error. Although Wiener filtering can be used to recognize pile-up, it suffers from errors due to pulse shape variation from detector nonlinearity, readout dependence on subsample arrival times, and stability issues from the ill-posed deconvolution problem of recovering Dirac delta-functions from smooth data. Due to these factors, we have developed a processing method that exploits singular value decomposition to (1) separate single-pulse records from piled-up records in training data and (2) construct a model of single-pulse records that accounts for varying pulse shape with amplitude, arrival time, and baseline level, suitable for detecting nearly-coincident events. We show that the resulting processing advances can reduce the required performance specifications of the detectors and readout system or, equivalently, enable larger sensor arrays and better constraints on the neutrino mass.

  7. An IR and Calorimetric Investigation of the Structural, Crystal-Chemical and Thermodynamic Properties of Hydrogrossular

    NASA Astrophysics Data System (ADS)

    Geiger, C. A.; Dachs, E.

    2012-04-01

    their collective interactions measurably affect the lattice dynamic (i.e. thermodynamic) behavior. The low temperature heat capacity behavior was investigated with a commercially designed relaxation calorimeter between 5 and 300 K on a mg-sized sample. The heat capacity data are well behaved at T < 300 K and show a monotonic decrease in magnitude with decreasing temperature. A standard third-law entropy value of So = 421.7 ± 1.6 J/mol·K was calculated. Using this new calorimetric-based So value and published standard enthalpy of formation data for katoite, a calorimetric-based Gibbs free energy of formation at 298 K can be obtained as ΔG°f = -5021.2 kJ/mol. The Cp data show no evidence for any phase transition as possibly expected by the change in OH-mode behavior with decreasing temperature. We have no explanation for the appearance of the additional modes. It is worth noting that the katoite crystal structure in terms of lattice dynamic or thermodynamic behavior should be thought of having OH groups and not O4H4 clusters or polyhedral units as is often written in the literature. The single crystallographic OH group in katoite shows very weak, if any, hydrogen bonding and the H atoms have large amplitudes of vibration. The weak H bonding controls the nature of low energy OH-related vibrations and this leads to its large So value.

  8. Seasonal Variability in Calorimetric Energy Content of Two Caribbean Mesophotic Corals.

    PubMed

    Brandtneris, Viktor W; Brandt, Marilyn E; Glynn, Peter W; Gyory, Joanna; Smith, Tyler B

    2016-01-01

    Energetic responses of zooxanthellate reef corals along depth gradients have relevance to the refugia potential of mesophotic coral ecosystems (MCEs). Previous observations suggested that MCEs in the Caribbean are thermally buffered during the warmest parts of the year and occur within or just below the chlorophyll maximum, suggesting abundant trophic resources. However, it is not known if mesophotic corals can maintain constant energy needs throughout the year with changing environmental and biological conditions. The energetic content of tissues from the stony coral species Orbicella faveolata and Agaricia lamarcki was measured on the southern insular shelf of St. Thomas, US Virgin Islands (USVI), using micro-bomb calorimetry. Three sites for each species, at depths of 6m, 25m, 38m and 63m, were selected to capture energetic differences across the major vertical range extent of both species in the USVI-and sampled over five periods from April 2013 to April 2014. Mesophotic colonies of O. faveolata exhibited a significant reduction in energetic content during the month of September 2013 compared to mid-depth and shallow colonies (p = 0.032), whereas A. lamarcki experienced similar energetic variability, but with a significant reduction in energy content that occurred in July 2013 for colonies at sites deeper than 25m (p = 0.014). The results of calorimetric analyses indicate that O. faveolata may be at risk during late summer stress events, possibly due to the timing of reproductive activities. The low-point of A. lamarcki energy content, which may also coincide with reproduction, occurs prior to seasonal stress events, indicating contrasting, species-specific responses to environmental variability on MCEs. PMID:27050430

  9. Calorimetric Study of Magnetic Field-Induced Phase Transitions in - Fulvalenium) -

    NASA Astrophysics Data System (ADS)

    Fortune, Nathanael Alexander

    The particular class of organic conductors known as the Bechgaard salts exhibit a variety of highly anisotropic magnetic, thermal, and electrical phenomena. At low temperatures (below 10 kelvin), the application of a strong magnetic field establishes an effectively lower-dimensional anisotropic Fermi surface, as manifested in a variety of quasi one dimensional and quasi two dimensional thermodynamic and transport properties. Most dramatically, an increasing magnetic field--after suppression of superconductivity, induces a second order phase transition from a metallic to a spin density wave semimetal, followed by a series of first order phase transitions between density wave semimetallic states. This thesis concerns the thermodynamic nature of the low temperature magnetic field induced phase transitions in the Bechgaard charge-transfer salt (TMTSF)2-Cl(O)4. Presented here are the first measurements of the specific heat in magnetic fields up to 30 tesla, as well as the design and construction of a small sample calorimeter capable of operating at dilution refrigerator temperatures in the challenging environment of the high field resistive Bitter magnets. From transport measurements, the existence of a magnetic field induced reentrance into the metallic state has previously been inferred. In this thesis, the unambiguous bulk thermodynamic character of the reentrance is calorimetrically demonstrated. The behavior of the electronic specific heat at the reentrant transition is shown to be consistent with magnetic field enhanced localization. Additionally, quantum oscillations in the high field semimetallic state and the presence of additional structure above the reentrant field are observed. Although these oscillations have also been observed in magnetoresistance and magnetization, the magnitude of the oscillations in the specific heat calls into question all known models for the physical origin of these oscillations.

  10. Thermodynamic model for calorimetric and phase coexistence properties of coal derived fluids. Final technical report

    SciTech Connect

    Kabadi, V.N.

    1992-10-01

    The work on this project was initiated on September 1, 1989. The project consisted of three different tasks. 1. A thermodynamic model to predict VLE and calorimetric properties of coal liquids. 2. VLE measurements at high temperature and high pressure for coal model compounds and 3. Chromatographic characterization of coal liquids for distribution of heteroatoms. The thermodynamic model developed is an extension of the previous model developed for VLE of coal derived fluids (DOE Grant no. FG22-86PC90541). The model uses the modified UNIFAC correlation for the liquid phase. Some unavailable UNIFAC interactions parameters have been regressed from experimental VLE and excess enthalpy data. The model is successful in predicting binary VLE and excess enthalpy data. Further refinements of the model are suggested. An apparatus for the high pressure high temperature VLE data measurements has been built and tested. Tetralin-Quinoline is the first binary system selected for data measurements. The equipment was tested by measuring 325{degree}C isotherm for this system and comparing it with literature data. Additional isotherms at 350{degree}C and 370{degree}C have been measured. The framework for a characterization procedure for coal derived liquids has been developed. A coal liquid is defined by a true molecular weight distribution and distribution of heteroatoms as a function of molecular weights. Size exclusions liquid chromatography, elemental analysis and FTIR spectroscopy methods are used to obtain the molecular weight and hetroatom distributions. Further work in this area should include refinements of the characterization procedure, high temperature high pressure VLE data measurements for selective model compound binary systems, and improvement of the thermodynamic model using the new measured data and consistent with the developments in the characterization procedure.

  11. Calorimetric measurement of afterheat in target materials for the accelerator production of tritium

    SciTech Connect

    Perry, R.B.; Zucker, M.S.

    1994-06-01

    The estimate of afterheat in a spallation target of lead (Pb) or tungsten (W), by calorimetry, is the purpose of this experiment in support of the Accelerator Production of Tritium (APT). Such measurements are needed to confirm code calculations, these being the only practical way of gaining this type of information in a form suitable to aid the design of the APT machine. Knowledge of the magnitude and duration of afterheat resulting from decay of activation products produced by proton bombardment of the target is necessary to quantify APT safety assumptions, to design target cooling and safety systems, and to reduce technical risk. Direct calorimetric measurement of the afterheat for the appropriate incident proton energies is more reliable than the available alternative, which is indirect, based on data from gamma-ray spectroscopy measurements. The basic concept, a direct measurement of decay afterheat which bypasses the laborious classical way of determining this quantity, has been demonstrated to work. The gamma-ray energy given off by the decay products produced in the activation of lead or tungsten with high-energy protons apparently does represent a significant fraction of the total decay energy. A calorimeter designed for measurement of isotopes decaying by alpha emission must be modified to reduce energy lost with escaping gamma rays. Replacement of the aluminum liner with a tungsten liner in the SSC measurement chamber resulted in a 270% increase in measured heat, proving that the energy loss in the earlier (1992) measurements was significant. Gamma-ray measurements are needed to confirm the gamma-ray absorption calculations for the calorimeter to determine the correction for loss of heat due to transmission of high-energy gamma rays through the calorimeter walls. The experiments at BLIP have shown that calorimetry can be a useful tool in measuring the afterheat in APT target materials.

  12. Calorimetric studies of the kinetic unfreezing of molecular motions in hydrated lysozyme, hemoglobin, and myoglobin.

    PubMed Central

    Sartor, G; Mayer, E; Johari, G P

    1994-01-01

    Differential scanning calorimetric (DSC) studies of the glassy states of as-received and hydrated lysozyme, hemoglobin, and myoglobin powders, with water contents of < or = 0.25, < or = 0.30, and < or = 0.29 g/g of protein, show that their heat capacity slowly increases with increasing temperature, without showing an abrupt increase characteristic of glass-->liquid transition. Annealing (also referred to as physical aging) of the hydrated proteins causes their DSC scans to show an endothermic region, similar to an overshoot, immediately above the annealing temperature. This annealing effect appears at all temperatures between approximately 150 and 300 K. The area under these peaks increases with increasing annealing time at a fixed temperature. The effects are attributed to the presence of a large number of local structures in which macromolecular segments diffuse at different time scales over a broad range. The lowest time scale corresponds to the > N-H and -O-H group motions which become kinetically unfrozen at approximately 150-170 K on heating at a rate of 30 K min-1 and which have a relaxation time of 5-10 s in this temperature range. The annealing effects confirm that the individual glass transition of the relaxing local regions is spread over a temperature range up to the denaturation temperature region of the proteins. The interpretation is supported by simulation of DSC scans in which the distribution of relaxation times is assumed to be exceptionally broad and in which annealing done at several temperatures over a wide range produces endothermic effects (or regions of DSC scans) qualitatively similar to those observed for the hydrated proteins. PMID:8130342

  13. Seasonal Variability in Calorimetric Energy Content of Two Caribbean Mesophotic Corals

    PubMed Central

    Brandtneris, Viktor W.; Brandt, Marilyn E.; Glynn, Peter W.; Gyory, Joanna; Smith, Tyler B.

    2016-01-01

    Energetic responses of zooxanthellate reef corals along depth gradients have relevance to the refugia potential of mesophotic coral ecosystems (MCEs). Previous observations suggested that MCEs in the Caribbean are thermally buffered during the warmest parts of the year and occur within or just below the chlorophyll maximum, suggesting abundant trophic resources. However, it is not known if mesophotic corals can maintain constant energy needs throughout the year with changing environmental and biological conditions. The energetic content of tissues from the stony coral species Orbicella faveolata and Agaricia lamarcki was measured on the southern insular shelf of St. Thomas, US Virgin Islands (USVI), using micro-bomb calorimetry. Three sites for each species, at depths of 6m, 25m, 38m and 63m, were selected to capture energetic differences across the major vertical range extent of both species in the USVI—and sampled over five periods from April 2013 to April 2014. Mesophotic colonies of O. faveolata exhibited a significant reduction in energetic content during the month of September 2013 compared to mid-depth and shallow colonies (p = 0.032), whereas A. lamarcki experienced similar energetic variability, but with a significant reduction in energy content that occurred in July 2013 for colonies at sites deeper than 25m (p = 0.014). The results of calorimetric analyses indicate that O. faveolata may be at risk during late summer stress events, possibly due to the timing of reproductive activities. The low-point of A. lamarcki energy content, which may also coincide with reproduction, occurs prior to seasonal stress events, indicating contrasting, species-specific responses to environmental variability on MCEs. PMID:27050430

  14. Cri du Chat syndrome

    PubMed Central

    Cerruti Mainardi, Paola

    2006-01-01

    The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and mental retardation. Malformations, although not very frequent, may be present: cardiac, neurological and renal abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism. Molecular cytogenetic analysis has allowed a cytogenetic and phenotypic map of 5p to be defined, even if results from the studies reported up to now are not completely in agreement. Genotype-phenotype correlation studies showed a clinical and cytogenetic variability. The identification of phenotypic subsets associated with a specific size and type of deletion is of diagnostic and prognostic relevance. Specific growth and psychomotor development charts have been established. Two genes, Semaphorin F (SEMAF) and δ-catenin (CTNND2), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in CdCS patients. Deletion of the telomerase reverse transcriptase (hTERT) gene, localised to 5p15.33, could contribute to the phenotypic changes in CdCS. The critical regions were recently refined by using array comparative genomic hybridisation. The cat-like cry critical region was further narrowed using quantitative polymerase chain reaction (PCR) and three candidate genes were characterised in this region. The diagnosis is based on typical clinical manifestations. Karyotype analysis and, in doubtful cases, FISH analysis will confirm the diagnosis. There is no specific therapy for CdCS but early rehabilitative and educational interventions improve the prognosis and considerable progress has been made in

  15. L'Aventure du LHC

    ScienceCinema

    None

    2011-10-06

    Cette présentation s?adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l?engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

  16. L'Aventure du LHC

    SciTech Connect

    2010-06-11

    Cette présentation s’adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l’engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

  17. Analbite - Sanidine Thermodynamic Mixing Properties: Highly Precise HF Solution Calorimetric Data Across A Twenty-Member Crystalline Solution Series

    NASA Astrophysics Data System (ADS)

    Hovis, G. L.

    2013-12-01

    Enthalpies of K-Na mixing for the analbite - sanidine feldspar series were investigated by Hovis (1988, J. Petrology) in the early 80's. That work was based on data at a limited number of compositions, owing to the large sample sizes required for HF solution calorimetric measurements at the time. Thermodynamic mixing properties for mineral series, especially those exhibiting compositionally asymmetric mixing quantities, are best defined when samples at a large number of compositions are utilized. Enabled by the small sample sizes now possible for HF solution calorimetric dissolutions (Hovis et al., 1998, Amer. Mineral.), we revisit feldspar thermodynamic properties, having synthesized an analbite - sanidine series consisting of samples at 20 compositions. Solution calorimetric experiments on these samples at 50 °C in 20.1 wt% HF under isoperibolic conditions have resulted in highly precise calorimetric data (standard deviation per sample averaging 0.06 % of the heat of solution). Although enthalpies of K-Na mixing based on the new data display some degree of compositional asymmetry, with a maximum value of 4.8 kJ/mol at a mole fraction potassium of 0.47, the distribution of enthalpy-of-mixing values remains nearly symmetric with respect to K content. This contrasts significantly with data for Al-Si ordered low albite - microcline crystalline solutions, reinvestigated via synthesis of a 21-member series, which show significantly higher mixing magnitudes and considerably greater asymmetry with respect to composition. The maximization of enthalpies of K-Na mixing at sodic compositions correlates well with the sodic critical compositions for both solvi. The lower mixing magnitudes for analbite - sanidine are consistent with the comparatively lower critical temperature of the analbite - sanidine solvus (e.g., Smith & Parsons, 1974, Mineral. Mag.) relative to that for low albite - microcline (Bachinski & Müller, 1971, J. Petrology). Entropies of K-Na mixing for

  18. Analbite - Sanidine Thermodynamic Mixing Properties: Highly Precise HF Solution Calorimetric Data Across A Twenty-Member Crystalline Solution Series

    NASA Astrophysics Data System (ADS)

    Hovis, G. L.

    2012-12-01

    Enthalpies of K-Na mixing for the analbite - sanidine feldspar series were investigated by Hovis (1988, J. Petrology) in the early 80's. That work was based on data at a limited number of compositions, owing to the large sample sizes required for HF solution calorimetric measurements at the time. Thermodynamic mixing properties for mineral series, especially those exhibiting compositionally asymmetric mixing quantities, are best defined when samples at a large number of compositions are utilized. Enabled by the small sample sizes now possible for HF solution calorimetric dissolutions (Hovis et al., 1998, Amer. Mineral.), we revisit feldspar thermodynamic properties, having synthesized an analbite - sanidine series consisting of samples at 20 compositions. Solution calorimetric experiments on these samples at 50 °C in 20.1 wt% HF under isoperibolic conditions have resulted in highly precise calorimetric data (standard deviation per sample averaging 0.06 % of the heat of solution). Although enthalpies of K-Na mixing based on the new data display some degree of compositional asymmetry, with a maximum value of 4.8 kJ/mol at a mole fraction potassium of 0.47, the distribution of enthalpy-of-mixing values remains nearly symmetric with respect to K content. This contrasts significantly with data for Al-Si ordered low albite - microcline crystalline solutions, reinvestigated via synthesis of a 21-member series, which show significantly higher mixing magnitudes and considerably greater asymmetry with respect to composition. The maximization of enthalpies of K-Na mixing at sodic compositions correlates well with the sodic critical compositions for both solvi. The lower mixing magnitudes for analbite - sanidine are consistent with the comparatively lower critical temperature of the analbite - sanidine solvus (e.g., Smith & Parsons, 1974, Mineral. Mag.) relative to that for low albite - microcline (Bachinski & Müller, 1971, J. Petrology). Entropies of K-Na mixing for

  19. Investigation of ferroelectric phase transitions of water in nanoporous silicates in simultaneous electrical noise and calorimetric measurements

    NASA Astrophysics Data System (ADS)

    Bordonskiy, G. S.; Orlov, A. O.

    2014-08-01

    The phase transitions of water in the nanoporous silicate materials SBA-15 and MCM-41 with an ordered system of cylindrical pores have been investigated. Measurements of low-frequency electrical noises (Barkhausen noises) in the frequency range of 1-100 Hz have been performed simultaneously with relative calorimetric measurements. It has been found that the voltage of electrical fluctuations increases approximately 100 times in the temperature range from -30 to -50°C, which is associated with the first-order and second-order ferroelectric phase transitions. It has been assumed that the ferroelectric ice XI can be formed in capillary pores of the materials under investigations.

  20. Calorimetric and spectroscopic studies of aminoglycoside binding to AT-rich DNA triple helices

    PubMed Central

    Xi, Hongjuan; Kumar, Sunil; Dosen-Micovic, Ljiljana; Arya, Dev P.

    2013-01-01

    Calorimetric and fluorescence techniques were used to characterize the binding of aminoglycosides-neomycin, paromomycin, and ribostamycin, with 5′-dA12-x-dT12-x-dT12-3′ intramolecular DNA triplex (x = hexaethylene glycol) and poly(dA).2poly(dT) triplex. Our results demonstrate the following features: (1) UV thermal analysis reveals that the Tm for triplex decreases with increasing pH value in the presence of neomycin, while the Tm for the duplex remains unchanged. (2) The binding affinity of neomycin decreases with increased pH, although there is an increase in observed binding enthalpy. (3) ITC studies conducted in two buffers (sodium cacodylate and MOPS) yield the number of protonated drug amino groups (Δn) as 0.29 and 0.40 for neomycin and paromomycin interaction with 5′-dA12-x-dT12-x-dT12-3′, respectively. (4) The specific heat capacity change (ΔCp) determined by ITC studies is negative, with more negative values at lower salt concentrations. From 100 mM to 250 mM KCl, the ΔCp ranges from −402 to −60 cal/(mol K) for neomycin. At pH 5.5, a more positive ΔCp is observed, with a value of −98 cal/(mol K) at 100 mM KCl. ΔCp is not significantly affected by ionic strength. (5) Salt dependence studies reveal that there are at least three amino groups of neomycin participating in the electrostatic interactions with the triplex. (6) FID studies using thiazole orange were used to derive the AC50 (aminoglycoside concentration needed to displace 50% of the dye from the triplex) values. Neomycin shows a seven fold higher affinity than paromomycin and eleven fold higher affinity than ribostamycin at pH 6.8. (7) Modeling studies, consistent with UV and ITC results, show the importance of an additional positive charge in triplex recognition by neomycin. The modeling and thermodynamic studies indicate that neomycin binding to the DNA triplex depends upon significant contributions from charge as well as shape complementarity of the drug to the DNA triplex

  1. Investigation of a zirconia co-fired ceramic calorimetric microsensor for high-temperature flow measurements

    NASA Astrophysics Data System (ADS)

    Lekholm, Ville; Persson, Anders; Klintberg, Lena; Thornell, Greger

    2015-06-01

    This paper describes the design, fabrication and characterization of a flow sensor for high-temperature, or otherwise aggressive, environments, like, e.g. the propulsion system of a small spacecraft. The sensor was fabricated using 8 mol% yttria stabilized zirconia (YSZ8) high-temperature co-fired ceramic (HTCC) tape and screen printed platinum paste. A calorimetric flow sensor design was used, with five 80 µm wide conductors, separated by 160 µm, in a 0.4 mm wide, 0.1 mm deep and 12.5 mm long flow channel. The central conductor was used as a heater for the sensor, and the two adjacent conductors were used to resistively measure the heat transferred from the heater by forced convection. The two outermost conductors were used to study the influence of an auxiliary heat source on the sensor. The resistances of the sensor conductors were measured using four-point connections, as the gas flow rate was slowly increased from 0 to 40 sccm, with different power supplied through the central heater, as well as with an upstream or downstream heater powered. In this study, the thermal and electrical integrability of microcomponents on the YSZ8 substrate was of particular interest and, hence, the influence of thermal and ionic conduction in the substrate was studied in detail. The effect of the ion conductivity of YSZ8 was studied by measuring the resistance of a platinum conductor and the resistance between two adjacent conductors on YSZ8, in a furnace at temperatures from 20 to 930 °C and by measuring the resistance with increasing current through a conductor. With this design, the influence of ion conductivity through the substrate became apparent above 700 °C. The sensitivity of the sensor was up to 1 mΩ sccm-1 in a range of 0-10 sccm. The results show that the signal from the sensor is influenced by the integrated auxiliary heating conductors and that these auxiliary heaters provide a way to balance disturbing heat sources, e.g. thrusters or other electronics, in

  2. Development of Metallic Magnetic Calorimeters for High Precision Measurements of Calorimetric Re-187 and Ho-163 Spectra

    NASA Technical Reports Server (NTRS)

    Ranitzsch, P. C.-O.; Porst, J.-P.; Kempf, S.; Pies, C.; Schafer, S.; Hengstler, D.; Fleischmann, A.; Enss, C.; Gastaldo, L.

    2012-01-01

    The measurement of calorimetric spectra following atomic weak decays, beta (b) and electron capture (EC), of nuclides having a very low Q-value, can provide an impressively high sensitivity to a non-vanishing neutrino mass. The achievable sensitivity in this kind of experiments is directly connected to the performance of the used detectors. In particular an energy resolution of a few eV and a pulse formation time well below 1 microsecond are required. Low temperature Metallic Magnetic Calorimeters (MMCs) for soft X-rays have already shown an energy resolution of 2.0 eV FWHM and a pulse rise-time of about 90 ns for fully micro-fabricated detectors. We present the use of MMCs for high precision measurements of calorimetric spectra following the beta-decay of Re-187 and the EC of Ho-163. We show results obtained with detectors optimized for Re-187 and for Ho-163 experiments respectively. While the detectors equipped with superconducting Re absorbers have not yet reached the aimed performance, a first detector prototype with a Au absorber having implanted Ho-163 ions already shows excellent results. An energy resolution of 12 eV FWHM and a rise time of 90 ns were measured.

  3. Urea-induced dissociation and unfolding of dodecameric glutamine synthetase from Escherichia coli: calorimetric and spectral studies.

    PubMed Central

    Zolkiewski, M.; Nosworthy, N. J.; Ginsburg, A.

    1995-01-01

    Urea-induced dissociation and unfolding of manganese.glutamine synthetase (Mn.GS) have been studied at 37 degrees C (pH 7) by spectroscopic and calorimetric methods. In 0 to approximately 2 M urea, Mn.GS retains its dodecameric structure and full catalytic activity. Mn.GS is dissociated into subunits in 6 M urea, as evidenced by a 12-fold decrease in 90 degrees light scattering and a monomer molecular weight of 51,800 in sedimentation equilibrium studies. The light scattering decrease in 4 M urea parallels the time course of Trp exposure but occurs more rapidly than changes in secondary structure and Tyr exposure. Early and late kinetic steps appear to involve predominantly disruption of intra-ring and inter-ring subunit contacts, respectively, in the layered hexagonal structure of Mn.GS. The enthalpies for transferring Mn.GS into urea solutions have been measured by titration calorimetry. After correcting for the enthalpy of binding urea to the protein, the enthalpy of dissociation and unfolding of Mn.GS is 14 +/- 4 cal/g. A net proton uptake of approximately 50 H+/dodecamer accompanies unfolding reactions. The calorimetric data are consistent with urea binding to multiple, independent sites in Mn.GS and the number of binding sites increasing approximately 9-fold during the protein unfolding. PMID:8520480

  4. Thermogravimetric and calorimetric characteristics during co-pyrolysis of municipal solid waste components.

    PubMed

    Ansah, Emmanuel; Wang, Lijun; Shahbazi, Abolghasem

    2016-10-01

    The thermogravimetric and calorimetric characteristics during pyrolysis of wood, paper, textile and polyethylene terephthalate (PET) plastic in municipal solid wastes (MSW), and co-pyrolysis of biomass-derived and plastic components with and without torrefaction were investigated. The active pyrolysis of the PET plastic occurred at a much higher temperature range between 360°C and 480°C than 220-380°C for the biomass derived components. The plastic pyrolyzed at a heating rate of 10°C/min had the highest maximum weight loss rate of 18.5wt%/min occurred at 420°C, followed by 10.8wt%/min at 340°C for both paper and textile, and 9.9wt%/min at 360°C for wood. At the end of the active pyrolysis stage, the final mass of paper, wood, textile and PET was 28.77%, 26.78%, 21.62% and 18.31%, respectively. During pyrolysis of individual MSW components at 500°C, the wood required the least amount of heat at 665.2J/g, compared to 2483.2J/g for textile, 2059.4J/g for paper and 2256.1J/g for PET plastic. The PET plastic had much higher activation energy of 181.86kJ/mol, compared to 41.47kJ/mol for wood, 50.01kJ/mol for paper and 36.65kJ/mol for textile during pyrolysis at a heating rate of 10°C/min. H2O and H2 peaks were observed on the MS curves for the pyrolysis of three biomass-derived materials but there was no obvious H2O and H2 peaks on the MS curves of PET plastic. There was a significant interaction between biomass and PET plastic during co-pyrolysis if the biomass fraction was dominant. The amount of heat required for the co-pyrolysis of the biomass and plastic mixture increased with the increase of plastic mass fraction in the mixture. Torrefaction at a proper temperature and time could improve the grindability of PET plastic. The increase of torrefaction temperature and time did not affect the temperature where the maximum pyrolytic rates occurred for both biomass and plastic but decreased the maximum pyrolysis rate of biomass and increased the maximum pyrolysis

  5. Calorimetric study of Te15(Se100- x Bi x )85 glassy alloys using differential thermal analysis

    NASA Astrophysics Data System (ADS)

    Kumar, Kameshwar; Thakur, Nagesh; Bhatt, S. S.; Sharma, Pankaj

    2010-10-01

    A calorimetric study of Te15(Se100- x Bi x )85 glassy alloys (x = 0, 1, 2, 3 and 4 at. %) is reported. Differential thermal analysis (DTA) was performed at heating rates of 10, 15, 20 and 25 K/min. The spectra were used to determine the glass transition temperature, Tg , the crystallisation temperature, Tc and the melting temperature, Tm . All these parameters shift to higher values with increasing heating rate, β. The glass transition temperature and the melting temperature increase, and the crystallisation temperature decreases, with increase in the Bi content, x. The activation energy of the glass transition, Eg , was evaluated using the Moynihan and Kissinger methods. The activation energy of crystallisation, Ec , was calculated using modified Kissinger and Matusita approaches. The thermal stability of these glasses has been studied and found to decrease with increase in Bi content. The results obtained are explained on the basis of a chemically ordered network model and an average coordination number.

  6. A micromachined calorimetric gas sensor: an application of electrodeposited nanostructured palladium for the detection of combustible gases.

    PubMed

    Bartlett, Philip N; Guerin, Samuel

    2003-01-01

    Palladium films with regular nanoarchitectures were electrochemically deposited from the hexagonal (H1) lyotropic liquid crystalline phase of the nonionic surfactant octaethyleneglycol monohexadecyl ether (C16EO8) onto micromachined silicon hotplate structures. The H1-e Pd films were shown to have high surface areas (approximately 28 m2 g(-1)) and to act as effective and stable catalysts for the detection of methane in air on heating to 500 degrees C. The response of the H1-e Pd-coated planar pellistors was found to be linearly proportional to the concentration of methane between 0 and 2.5% in air with a detection limit below 0.125%. Our results show that the electrochemical deposition of nanostructured metal films offers a promising approach to the fabrication of micromachined calorimetric gas sensors for combustible gases. PMID:12530828

  7. Approche de prise en charge du trouble du spectre de l’autisme

    PubMed Central

    Lee, Patrick F.; Thomas, Roger E.; Lee, Patricia A.

    2015-01-01

    Résumé Objectif Se pencher sur les critères diagnostiques du trouble du spectre de l’autisme (TSA) comme les définit le Manuel diagnostique et statistique des troubles mentaux, cinquième édition (DSM-V), et concevoir une approche de prise en charge du TSA à l’aide du cadre CanMEDS–Médecine familiale (CanMEDS-MF). Sources d’information Le DSM-V, publié par l’American Psychiatric Association en mai 2013, énonce de nouveaux critères diagnostiques du TSA. Le cadre CanMEDS-MF du Collège des médecins de famille du Canada fournit un plan d’orientation pour la prise en charge complexe du TSA. Nous avons utilisé des données recueillies par le Centers for Disease Control and Prevention afin de déterminer la prévalence du TSA, ainsi que la revue systématique et méta-analyse détaillée effectuée par le National Institute for Health and Care Excellence du R.-U. pour ses lignes directrices sur le TSA dans le but d’évaluer les données probantes issues de plus de 100 interventions. Message principal Selon les données du Centers for Disease Control and Prevention, la prévalence du TSA se chiffrait à 1 sur 88 en 2008 aux États-Unis. La classification du TSA dans la quatrième édition du DSM incluait l’autisme, le syndrome d’Asperger, le trouble envahissant du développement et le trouble désintégratif de l’enfance. La dernière révision du DSM-V réunit tous ces troubles sous la mention TSA, avec différents niveaux de sévérité. La prise en charge du TSA est complexe; elle exige les efforts d’une équipe multidisciplinaire ainsi que des soins continus. Les rôles CanMEDS-MF fournissent un cadre de prise en charge. Conclusion Les médecins de famille sont au cœur de l’équipe de soins multidisciplinaire pour le TSA, et le cadre CanMEDS-MF tient lieu de plan détaillé pour guider la prise en charge d’un enfant atteint de TSA et aider la famille de cet enfant.

  8. A Calorimetric Study of Almandine: Are the Thermodynamic Properties of the End-Member Aluminosilicate Garnets Finally Known Quantitatively?

    NASA Astrophysics Data System (ADS)

    Dachs, E.; Geiger, C. A.; Benisek, A.

    2012-12-01

    The aluminosilicate garnets (E3Al2Si3O12 with E = Fe2+, Mn2+, Ca, Mg) form an important rock-forming mineral group. Much study has been directed toward determining their thermodynamic properties. The iron end-member almandine (Fe3Al2Si3O12) is a key phase in many petrologic investigations. As part of an ongoing calorimetric and thermodynamic study of the aluminosilicate garnets, the heat capacity of three synthetic well-characterized polycrystalline almandine garnets and one natural almandine-rich single crystal was measured. The various garnets were characterized by optical microscopy, electron-microprobe analysis, X-ray powder diffraction and 57Fe Mössbauer spectroscopy. Heat capacity measurements were performed in the temperature range 3 to 300 K using relaxation calorimetry and between 282 and 764 K using DSC methods. From the former, So values between 336.7 ± 0.8 and 337.8 ± 0.8 J/molK are calculated for the different samples. The smaller value is considered the best So for end-member stoichiometric almandine, because it derives from the "best" Fe3+-free synthetic sample. The Cp behavior for almandine at T > 298 K is given by the polynomial (in J/molK): Cp = 649.06(±4) - 3837.57(±122)T-0.5 - 1.44682(±0.06)107T-2 + 1.94834(±0.09)109T-3, which is calculated using DSC data together with one published heat-content datum determined by transposed-drop calorimetry along with a new determination that gives H1181K - H302K = 415.0 ± 3.2 kJ/mole. Almandine shows a λ-type heat-capacity anomaly at low temperatures resulting from a paramagnetic-antiferromagnetic phase transition at about 9 K. The lattice heat capacity was calculated using the single-parameter phonon dispersion model of Komada and Westrum (1997), which allows the non-lattice heat capacity (Cex) behavior to be modelled. An analysis shows the presence of an electronic heat-capacity contribution (Cel - Schottky anomaly) around 17 K that is superimposed on a larger magnetic heat-capacity effect (Cmag

  9. Les plaies du tendon patellaire

    PubMed Central

    Mechchat, Atif; Elidrissi, Mohammed; Mardy, Abdelhak; Elayoubi, Abdelghni; Shimi, Mohammed; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2014-01-01

    Les plaies du tendon patellaire sont peu fréquentes et sont peu rapportés dans la littérature, contrairement aux ruptures sous cutanées. Les sections du tendon patellaire nécessitent une réparation immédiate afin de rétablir l'appareil extenseur et de permettre une récupération fonctionnelle précoce. A travers ce travail rétrospectif sur 13 cas, nous analysons les aspects épidémiologiques, thérapeutiques et pronostiques de ce type de pathologie en comparant différents scores. L’âge moyen est de 25 ans avec une prédominance masculine. Les étiologies sont dominées par les accidents de la voie publique (68%) et les agressions par agent tranchant (26%) et contendant (6 %). Tous nos patients ont bénéficié d'un parage chirurgical avec suture tendineuse direct protégée par un laçage au fils d'aciers en légère flexion. La rééducation est débutée après sédation des phénomènes inflammatoires. Au dernier recul les résultats sont excellents et bon à 92%. Nous n'avons pas noté de différence de force musculaire et d'amplitude articulaire entre le genou sain et le genou lésé. Les lésions ouvertes du tendon patellaire est relativement rare. La prise en charge chirurgicale rapide donne des résultats assez satisfaisants. La réparation est généralement renforcée par un semi-tendineux, synthétique ou métallique en forme de cadre de renfort pour faciliter la réadaptation et réduire le risque de récidive après la fin de l'immobilisation. PMID:25170379

  10. Learning about Cri du Chat Syndrome

    MedlinePlus

    ... chat syndrome - also known as 5p- syndrome and cat cry syndrome - is a rare genetic condition that ... du chat syndrome usually include a high-pitched cat-like cry, mental retardation, delayed development, distinctive facial ...

  11. Refractive-index-based calorimetric studies of RNAse T1 unfolding in small volumes using microinterferometric backscatter

    NASA Astrophysics Data System (ADS)

    Houlne, Michael P.; Hubbard, Darren S.; Makhatadze, George I.; Bornhop, Darryl J.

    1997-05-01

    Micro-interferometry, a novel technique developed by the authors, employs a linearly polarized laser, a fused silica capillary tube housing for the sample and a charged coupled device as a detector. A back scattered interference pattern, observed as a high contrast fringes, is produced when the laser is directed onto the capillary containing the sample. The positional change of the fringe pattern is a function of the refractive index of the media in the capillary. In the present work, the RNA enzyme RNase T1 is heated in the sample cell over a temperature range of 30 degrees C to 60 degrees C. Over this temperature range the molecule unfolds form the quaternary to the tertiary structure. This structure change is manifested as a refractive index change and is observed by monitoring the fringe position while ramping the cell temperature in a controlled fashion. From the refractive index response over the temperature range, the Gibbs free energy associated with unfolding is calculated. The authors show milli-degree temperature stability with a 0.1 micro-liter probe volume, thus demonstrating the application of this device in micro- calorimetric investigations.

  12. Calorimetric Low-Temperature Detectors for X-Ray Spectroscopy on Trapped Highly-Charged Heavy Ions

    NASA Technical Reports Server (NTRS)

    Kilbourne, Caroline; Kraft-Bermuth, S.; Andrianov, V.; Bleile, A.; Echler, A.; Egelhof, P.; Ilieva, S.; Kilbourne, C.; McCammon, D.

    2012-01-01

    The application of Calorimetric Low-Temperature Detectors (CLTDs) has been proposed at the Heavy-Ion TRAP facility HITRAP which is currently being installed at the Helmholtz Research Center for Heavy Ion Research GSI. This cold ion trap setup will allow the investigation of X-rays from ions practically at rest, for which the excellent energy resolution of CLTDs can be used to its full advantage. However, the relatively low intensities at HITRAP demand larger solid angles and an optimized cryogenic setup. The influence of external magnetic fields has to be taken into account. CLTDs will also be a substantial part of the instrumental equipment at the future Facility for Antiproton and Heavy Ion Research (FAIR), for which a wide variety of high-precision X-ray spectroscopy experiments has been proposed. This contribution will give an overview on the chances and challenges for the application of CLTDs at HITRAP as well as perspectives for future experiments at the FAIR facility.

  13. Surfactants induced release of a red emitting dye from the nanocavity of a molecular container: A spectroscopic and calorimetric study.

    PubMed

    Ahmed, Sayeed Ashique; Chatterjee, Aninda; Maity, Banibrata; Seth, Debabrata

    2016-08-01

    Supramolecular interaction of a red emitting dye Nile blue A (NBA) with Cucurbit[7]uril (CB7) in aqueous solution was studied and the release of the dye from the hydrophobic cavity of CB7 was reported. To investigate the supramolecular host-guest complex formation and release of dye, we have used the steady state absorption, fluorescence and time resolved fluorescence emission spectroscopy, (1)H NMR spectroscopy and isothermal titration calorimetry (ITC). The spectral properties of NBA were changed in the presence of CB7. The change in spectral features of NBA in presence of CB7 indicates the formation of supramolecular host-guest complexes. By using the SED equation the diameter of the complex was estimated. The complex formation further affirmed by the (1)H NMR study. Upfield and downfield shifts of the protons of NBA was observed in both the aliphatic and aromatic region. From the ITC measurement, we have drawn up the forces involved for the complexation of NBA with CB7. We have studied the release of NBA from the hydrophobic cavity of CB7 by using ionic, neutral surfactants and ionic liquid with the help of spectroscopic and calorimetric techniques. It is observed that on addition of SDS and ionic liquid (

  14. Calorimetric study of the superconducting and normal state properties of Ca(Fe1-xCox)2As2

    NASA Astrophysics Data System (ADS)

    Abdel-Hafiez, M.; Harnagea, L.; Singh, S.; Stockert, U.; Wurmehl, S.; Leps, N.; Klingeler, R.; Wolter, A. U. B.; Büchner, B.

    2012-12-01

    We present a calorimetric study on single crystals of Ca(Fe1-xCox)2As2 (x = 0, 0.032, 0.051, 0.056, 0.063, and 0.146). The combined first order spin-density wave/structural transition occurs in the parent CaFe2As2 compound at 168 K and gradually shifts to lower temperature for low doping levels (x = 0.032 and x = 0.051). It is completely suppressed upon higher doping x >= 0.056. Simultaneously, superconductivity appears at lower temperature with a transition temperature around Tc ~ 14.1 K for Ca(Fe0.937Co0.063)2As2. The phase diagram of Ca(Fe0.937Co0.063)2As2 has been derived and the upper critical field is found to be μ0H(c)2 = 11.5 T and μ0H(ab)c2 = 19.4 T for the c and ab directions, respectively.

  15. Kinetic and calorimetric study of the adsorption of dyes on mesoporous activated carbon prepared from coconut coir dust.

    PubMed

    Macedo, Jeremias de Souza; da Costa Júnior, Nivan Bezerra; Almeida, Luis Eduardo; Vieira, Eunice Fragoso da Silva; Cestari, Antonio Reinaldo; Gimenez, Iara de Fátima; Villarreal Carreño, Neftali Lênin; Barreto, Ledjane Silva

    2006-06-15

    Mesoporous activated carbon has been prepared from coconut coir dust as support for adsorption of some model dye molecules from aqueous solutions. The methylene blue (MB) and remazol yellow (RY) molecules were chosen for study of the adsorption capacity of cationic and anionic dyes onto prepared activated carbon. The adsorption kinetics was studied with the Lagergren first- and pseudo-second-order kinetic models as well as the intraparticle diffusion model. The results for both dyes suggested a multimechanism sorption process. The adsorption mechanisms in the systems dyes/AC follow pseudo-second-order kinetics with a significant contribution of intraparticle diffusion. The samples simultaneously present acidic and basic sites able to act as anchoring sites for basic and acidic dyes, respectively. Calorimetric studies reveal that dyes/AC interaction forces are correlated with the pH of the solution, which can be related to the charge distribution on the AC surface. These AC samples also exhibited very short equilibrium times for the adsorption of both dyes, which is an economically favorable requisite for the activated carbon described in this work, in addition to the local abundance of the raw material. PMID:16497318

  16. Spectroscopic and calorimetric investigations on the binding of phenazinium dyes safranine-O and phenosafranine to double stranded RNA polynucleotides.

    PubMed

    Saha, Baishakhi; Kumar, Gopinatha Suresh

    2016-08-01

    RNA targeting through small molecules that can selectively bind specific RNA structures is an important current strategy in therapeutic drug development. Towards this strategy a comparative study on the interaction of two phenazinium dyes, safranine-O and phenosafranine to double stranded RNAs, poly(I).poly(C), poly(A).poly(U) and poly(C).poly(G) was performed. Spectrophotometric and spectrofluorimetric studies revealed non-cooperative binding of the dyes to the duplex RNA with binding constants of the order 10(5)M(-1) with a higher affinity of safranine-O to poly(I).poly(C) followed by poly(A).poly(U) and poly(C).poly(G). Anisotropy and fluorescence quenching results confirmed an intercalation mode of binding for the dyes on these RNAs. Binding induced conformational changes in the RNA polynucleotides were revealed from circular dichroism data. Thermal melting study and DSC experiments demonstrated stabilization of dye-RNA complexes. Calorimetric studies revealed that the binding was accompanied by a large positive entropy term with a small negative enthalpy contributions. Significant hydrophobic forces in the complexation of the double stranded RNAs with the dyes were confirmed from the negative heat capacity changes. Enthalpy-entropy compensation was also observed in the binding. Parsing of the Gibbs energy suggested a larger non-electrostatic contribution in all the cases. The results presented here may be helpful to design new types of RNA-based therapeutic agents. PMID:27236048

  17. Calorimetric AC loss measurement of MgB2 superconducting tape in an alternating transport current and direct magnetic field

    NASA Astrophysics Data System (ADS)

    See, K. W.; Xu, X.; Horvat, J.; Cook, C. D.; Dou, S. X.

    2012-11-01

    Applications of MgB2 superconductors in electrical engineering have been widely reported, and various studies have been made to define their alternating current (AC) losses. However, studies on the transport losses with an applied transverse DC magnetic field have not been conducted, even though this is one of the favored conditions in applications of practical MgB2 tapes. Methods and techniques used to characterize and measure these losses have so far been grouped into ‘electrical’ and ‘calorimetric’ approaches with external conditions set to resemble the application conditions. In this paper, we present a new approach to mounting the sample and employ the calorimetric method to accurately determine the losses in the concurrent application of AC transport current and DC magnetic fields that are likely to be experienced in practical devices such as generators and motors. This technique provides great simplification compared to the pickup coil and lock-in amplifier methods and is applied to a long length (˜10 cm) superconducting tape. The AC loss data at 20 and 30 K will be presented in an applied transport current of 50 Hz under external DC magnetic fields. The results are found to be higher than the theoretical predictions because of the metallic fraction of the tape that contributes quite significantly to the total losses. The data, however, will allow minimization of losses in practical MgB2 coils and will be used in the verification of numerical coil models.

  18. Determination of Nuclear Charge Distributions of Fission Fragments from ^{235}U (n_th, f) with Calorimetric Low Temperature Detectors

    NASA Astrophysics Data System (ADS)

    Grabitz, P.; Andrianov, V.; Bishop, S.; Blanc, A.; Dubey, S.; Echler, A.; Egelhof, P.; Faust, H.; Gönnenwein, F.; Gomez-Guzman, J. M.; Köster, U.; Kraft-Bermuth, S.; Mutterer, M.; Scholz, P.; Stolte, S.

    2016-08-01

    Calorimetric low temperature detectors (CLTD's) for heavy-ion detection have been combined with the LOHENGRIN recoil separator at the ILL Grenoble for the determination of nuclear charge distributions of fission fragments produced by thermal neutron-induced fission of ^{235}U. The LOHENGRIN spectrometer separates fission fragments according to their mass-to-ionic-charge ratio and their kinetic energy, but has no selectivity with respect to nuclear charges Z. For the separation of the nuclear charges, one can exploit the nuclear charge-dependent energy loss of the fragments passing through an energy degrader foil (absorber method). This separation requires detector systems with high energy resolution and negligible pulse height defect, as well as degrader foils which are optimized with respect to thickness, homogeneity, and energy loss straggling. In the present, contribution results of test measurements at the Maier Leibnitz tandem accelerator facility in Munich with ^{109}Ag and ^{127}I beams with the aim to determine the most suitable degrader material, as well as measurements at the Institut Laue-Langevin will be presented. These include a systematic study of the quality of Z-separation of fission fragments in the mass range 82le A le 132 and a systematic measurement of ^{92}Rb fission yields, as well as investigations of fission yields toward the symmetry region.

  19. pH-tuneable binding of 2′-phospho-ADP-ribose to ketopantoate reductase: a structural and calorimetric study

    SciTech Connect

    Ciulli, Alessio; Lobley, Carina M. C.; Tuck, Kellie L.; Smith, Alison G.; Blundell, Tom L.; Abell, Chris

    2007-02-01

    A combined crystallographic, calorimetric and mutagenic study has been used to show how changes in pH give rise to two distinct binding modes of 2′-phospho-ADP-ribose to ketopantoate reductase. The crystal structure of Escherichia coli ketopantoate reductase in complex with 2′-monophosphoadenosine 5′-diphosphoribose, a fragment of NADP{sup +} that lacks the nicotinamide ring, is reported. The ligand is bound at the enzyme active site in the opposite orientation to that observed for NADP{sup +}, with the adenine ring occupying the lipophilic nicotinamide pocket. Isothermal titration calorimetry with R31A and N98A mutants of the enzyme is used to show that the unusual ‘reversed binding mode’ observed in the crystal is triggered by changes in the protonation of binding groups at low pH. This research has important implications for fragment-based approaches to drug design, namely that the crystallization conditions and the chemical modification of ligands can have unexpected effects on the binding modes.

  20. Determination of Nuclear Charge Distributions of Fission Fragments from ^{235} U (n_th , f) with Calorimetric Low Temperature Detectors

    NASA Astrophysics Data System (ADS)

    Grabitz, P.; Andrianov, V.; Bishop, S.; Blanc, A.; Dubey, S.; Echler, A.; Egelhof, P.; Faust, H.; Gönnenwein, F.; Gomez-Guzman, J. M.; Köster, U.; Kraft-Bermuth, S.; Mutterer, M.; Scholz, P.; Stolte, S.

    2016-03-01

    Calorimetric low temperature detectors (CLTD's) for heavy-ion detection have been combined with the LOHENGRIN recoil separator at the ILL Grenoble for the determination of nuclear charge distributions of fission fragments produced by thermal neutron-induced fission of ^{235} U. The LOHENGRIN spectrometer separates fission fragments according to their mass-to-ionic-charge ratio and their kinetic energy, but has no selectivity with respect to nuclear charges Z. For the separation of the nuclear charges, one can exploit the nuclear charge-dependent energy loss of the fragments passing through an energy degrader foil (absorber method). This separation requires detector systems with high energy resolution and negligible pulse height defect, as well as degrader foils which are optimized with respect to thickness, homogeneity, and energy loss straggling. In the present, contribution results of test measurements at the Maier Leibnitz tandem accelerator facility in Munich with ^{109} Ag and ^{127} I beams with the aim to determine the most suitable degrader material, as well as measurements at the Institut Laue-Langevin will be presented. These include a systematic study of the quality of Z-separation of fission fragments in the mass range 82≤ A ≤ 132 and a systematic measurement of ^{92} Rb fission yields, as well as investigations of fission yields toward the symmetry region.

  1. Design and performance tests of the calorimetric tract of a Compton Camera for small-animals imaging

    NASA Astrophysics Data System (ADS)

    Rossi, P.; Baldazzi, G.; Battistella, A.; Bello, M.; Bollini, D.; Bonvicini, V.; Fontana, C. L.; Gennaro, G.; Moschini, G.; Navarria, F.; Rashevsky, A.; Uzunov, N.; Zampa, G.; Zampa, N.; Vacchi, A.

    2011-02-01

    The bio-distribution and targeting capability of pharmaceuticals may be assessed in small animals by imaging gamma-rays emitted from radio-isotope markers. Detectors that exploit the Compton concept allow higher gamma-ray efficiency compared to conventional Anger cameras employing collimators, and feature sub-millimeter spatial resolution and compact geometry. We are developing a Compton Camera that has to address several requirements: the high rates typical of the Compton concept; detection of gamma-rays of different energies that may range from 140 keV ( 99 mTc) to 511 keV ( β+ emitters); presence of gamma and beta radiation with energies up to 2 MeV in case of 188Re. The camera consists of a thin position-sensitive Tracker that scatters the gamma ray, and a second position-sensitive detection system to totally absorb the energy of the scattered photons (Calorimeter). In this paper we present the design and discuss the realization of the calorimetric tract, including the choice of scintillator crystal, pixel size, and detector geometry. Simulations of the gamma-ray trajectories from source to detectors have helped to assess the accuracy of the system and decide on camera design. Crystals of different materials, such as LaBr 3 GSO and YAP, and of different size, in continuous or segmented geometry, have been optically coupled to a multi-anode Hamamatsu H8500 detector, allowing measurements of spatial resolution and efficiency.

  2. Pru du 2S albumin or Pru du vicilin?

    PubMed

    Garino, Cristiano; De Paolis, Angelo; Coïsson, Jean Daniel; Arlorio, Marco

    2015-06-01

    A short partial sequence of 28 amino acids is all the information we have so far about the putative allergen 2S albumin from almond. The aim of this work was to analyze this information using mainly bioinformatics tools, in order to verify its rightness. Based on the results reported in the paper describing this allergen from almond, we analyzed the original data of amino acids sequencing through available software. The degree of homology of the almond 12kDa protein with any other known 2S albumin appears to be much lower than the one reported in the paper that firstly described it. In a publicly available cDNA library we discovered an expressed sequence tag which translation generates a protein that perfectly matches both of the sequencing outputs described in the same paper. A further analysis indicated that the latter protein seems to belong to the vicilin superfamily rather than to the prolamin one. The fact that also vicilins are seed storage proteins known to be highly allergenic would explain the IgE reactivity originally observed. Based on our observations we suggest that the IgE reactive 12kDa protein from almond currently known as Pru du 2S albumin is in reality the cleaved N-terminal region of a 7S vicilin like protein. PMID:25854802

  3. Biokinetics and dosimetry of depleted uranium (DU) in rats implanted with DU fragments.

    SciTech Connect

    Guilmette, Ray A.; Hahn, Fletcher F.; Durbin, P. W.

    2004-01-01

    A number of U. S. veterans of the Persian Gulf War were wounded with depleted uranium (DU) metal fragments as a result of 'friendly fire' incidents, in which Abrams tanks and Bradley fighting vehicles were struck by DU anti-armor munitions. Some of the crew members who survived were left with multiple small fragments of DU in their muscles and soft tissues. The number, size and location of the fragments made them inoperable in general, and therefore subject to long-term retention. Because there was inadequate data to predict the potential carcinogenicity of DU fragments in soft tissues, Hahn et al. (2003) conducted a lifespan cancer study in rats. As part of that study, a number of rats were maintained to study the biokinetics and dosimetry of DU implanted intramuscularly in male Wistar rats. Typically, four metal fragments, either as cylindrical pellets or square wafers were implanted into the biceps femoris muscles of the rats. Urine samples were collected periodically during their lifespans, and DU was analyzed in kidneys and eviscerated carcass (minus the implant sites) at death. The daily DU urinary excretion rate increased steeply during the first 30 d after implantation peaking at about 90 d at 3-10 x 10{sup -3}%/d. During the first 150 d, the average excretion rate was 2.4 x 10{sup -3}%/d, decreasing thereafter to about 1 x 10{sup -3}%/d. Serial radiographs were made of the wound sites to monitor gross morphologic changes in the DU implant and the surrounding tissue. As early as 1 w after implantation, radiographs showed the presence of surface corrosion and small, dense bodies near the original implant, presumably DU. This corrosion from the surface of the implant continued with time, but did not result in an increasing amount of DU reaching the blood and urine after the first 3 mo. During this 3-mo period, connective tissue capsules formed around the implants, and are hypothesized to have reduced the access of DU to tissue fluids by limiting the diffusion

  4. Résultats du traitement du synovialosarcome des members

    PubMed Central

    Lukulunga, Loubet Unyendje; Moussa, Abdou Kadri; Mahfoud, Mustapha; El Bardouni, Ahmed; Ismail, Farid; Kharmaz, Mohammed; Berrada, Mohamed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Les synovialosarcomes, sarcomes de haut grade, sont de diagnostic tardif et le traitement est complexe et onéreux, nécessitant la mise en œuvre d'une équipe pluridisciplinaire. Le but de ce travail était d'apprécier les résultats de l'association de la chirurgie à la radio chimiothérapie des synovialosarcomes des membres. Il s'agissait d'une étude rétrospective portant sur des patients présentant de synovialosarcomes des membres pris en charge dans le service de chirurgie orthopédique et traumatologique du CHU Ibn SINA de Rabat allant de Janvier 2006 à Décembre 2011 (6 ans). Nous avons inclus les malades présentant de synovialosarcomes des membres dont la clinique et l'imagerie médicale étaient en faveur, confirmés par l'examen anatomopathologique et la prise en charge effectuée dans le service. Les patients ont été revus avec un recul moyen de 3 ans. Nous n'avons pas retenu les patients dont les dossiers étaient incomplets, perdus de vue. Nous avons apprécié les résultats selon les critères carcinologiques et le score MSTS (Musculoskeletal Tumor Society). La saisie et l'analyse des données ont été faites sur le logiciel SPSS Stastic 17.0 Nous avons colligé 20 cas de synovialosarcome des membres dans le Service de Chirurgie Orthopédique et Traumatologique au CHU Ibn SINA de Rabat Le sexe masculin a prédominé avec 65% (n = 13) avec un sex ratio 1,85. L’âge moyen a été de 42,6 ans avec des extrêmes allant de 20 ans et 70 ans. Notre délai moyen de consultation était de 14,42 mois. Tous les malades ont consulté pour une tuméfaction dans 100% (localisée au membre inférieur dans 65% (n = 13), membre supérieur dans 35% (n = 7). La douleur était associée à la tuméfaction dans 55% (n = 11), quant à l'altération de l’état général et l'ulcération de la masse, elles ont été notées dans 3 cas chacune. Nous avons réalisé un bilan d'imagerie médicale comprenant: radiographie standard, échographie, écho doppler

  5. Thermogravimetric, Calorimetric, and Structural Studies of the Co3 O4 /CoO Oxidation/Reduction Reaction

    NASA Astrophysics Data System (ADS)

    Unruh, Karl; Cichocki, Ronald; Kelly, Brian; Poirier, Gerald

    2015-03-01

    To better assess the potential of cobalt oxide for thermal energy storage (TES), the Co3O4/CoO oxidation/reduction reaction has been studied by thermogravimetric (TGA), calorimetric (DSC), and x-ray diffraction (XRD) measurements in N2 and atmospheric air environments. TGA measurements showed an abrupt mass loss of about 6.6% in both N2 and air, consistent with the stoichiometric reduction of Co3O4 to CoO and structural measurements. The onset temperature of the reduction of Co3O4 in air was only weakly dependent on the sample heating rate and occurred at about 910 °C. The onset temperature for the oxidation of CoO varied between about 850 and 875 °C for cooling rates between 1 and 20 °C/min, but complete re-conversion to Co3O4 could only be achieved at the slowest cooling rates. Due to the dependence of the rate constant on the oxygen partial pressure, the oxidation of Co3O4 in a N2 environment occurred at temperatures between about 775 and 825 °C for heating rates between 1 and 20 °C/min and no subsequent re-oxidation of the reduced Co3O4 was observed on cooling to room temperature. In conjunction with a measured transition heat of about 600 J/g of Co3O4, these measurements indicate that cobalt oxide is a viable TES material.

  6. Spectroscopic and calorimetric studies on the binding of an indoloquinoline drug to parallel and antiparallel DNA triplexes.

    PubMed

    Riechert-Krause, Fanny; Autenrieth, Karolin; Eick, Andrea; Weisz, Klaus

    2013-01-01

    11-Phenyl-substituted indoloquinolines have been found to exhibit significant antiproliferative potency in cancer cells but to show only moderate affinity toward genomic double-helical DNA. In this study, parallel as well as antiparallel triple-helical DNA targets are employed to evaluate the triplex binding of these ligands. UV melting experiments with parallel triplexes indicate considerable interactions with the drug and a strong preference for TAT-rich triplexes in line with an increasing number of potential intercalation sites of similar binding strength between two TAT base triads. Via substitution of a singly charged aminoethylamine side chain by a longer and doubly charged bis(aminopropyl)amine substituent at the ligand, binding affinities increase and also start to exhibit long-range effects as indicated by a strong correlation between the binding affinity and the overall length of the TAT tract within the triplex stem. Compared to parallel triplexes, an antiparallel triplex with a GT-containing third strand constitutes a preferred target for the indoloquinoline drug. On the basis of pH-dependent titration experiments and corroborated by a Job analysis of continuous variation, binding of the drug to the GT triplex not only is strongly enhanced when the solution pH is lowered from 7 to 5 but also reveals a pH-dependent stoichiometry upon formation of the complex. Calorimetric data demonstrate that stronger binding of a protonated drug at acidic pH is associated with a more exothermic binding process. However, at pH 7 and 5, binding is enthalpically driven with additional favorable entropic contributions. PMID:23234257

  7. Calorimetric and spectroscopic studies on solvation energetics for H2 storage in the CO2/HCOOH system.

    PubMed

    Fink, Cornel; Katsyuba, Sergey; Laurenczy, Gabor

    2016-04-20

    Solvents playing a crucial role in many chemical reactions and additives can be used to shift the reaction equilibrium. Herein we study the enthalpy of mixing for selected solvents (aqueous, organic) and basic additives (amines, aqueous KOH) when mixed with formic acid with the aim to optimize hydrogen storage/delivery in the CO2/HCOOH system. Formic acid, resulting from carbon dioxide hydrogenation, reaches highest yields when effectively "removed" from the reaction equilibrium. In terms of energy efficiency, any heat released during CO2 hydrogenation has to be reused in the reverse reaction, during the production of hydrogen. In any scenario, the usage of basic chemicals, non-innocent solvents, causes higher energy release in CO2 hydrogenation, which has to be reused in the hydrogen delivery process. Therefore, the enthalpy of mixing is a valuable parameter for designing hydrogen storage devices since it allows the estimation of energy balance for the CO2 hydrogenation/H2 liberation cycle. The highest formic acid concentrations in direct catalytic CO2 hydrogenation under acidic conditions were reached in DMSO. DMSO exhibits considerably stronger interactions with formic acid compared to water as was observed in calorimetric measurements. This difference can be ascribed, at least partly, to stronger hydrogen bonding of FA to DMSO than to water in the corresponding solutions, examined by a combination of IR spectroscopic and quantum chemical studies. Furthermore, the investigation of DMSO/FA- and water/FA systems by (1)H- and (13)C-NMR spectroscopy revealed that only 1 : 1 aggregates are formed in the DMSO solutions of FA in a broad concentration range, while the stoichiometry and the number of the FA-water aggregates essentially depend on the concentration of aqueous solutions. PMID:26890151

  8. Calorimetric investigation of triazole-bridged Fe(II) spin-crossover one-dimensional materials: measuring the cooperativity.

    PubMed

    Roubeau, Olivier; Castro, Miguel; Burriel, Ramón; Haasnoot, Jaap G; Reedijk, Jan

    2011-03-31

    The relevance of abrupt magnetic and optical transitions exhibiting bistability in spin-crossover solids has been pointed out for their potential applications in optical or memory devices. In this respect, triazole-based one-dimensional coordination polymers are widely recognized as one of the most interesting systems. The measure of the interaction among spin-crossover centers at the origin of such cooperative behavior is of paramount importance and has so far been realized through modeling of spin-crossover curves derived mostly from magnetic measurements. Here, a new series of triazole-based one-dimensional coordination polymers of formula [Fe(Rtrz)(3)](A)(2)·xH(2)O with R = methoxyethyl and A = monovalent anion has been prepared that show complete and abrupt spin-crossover phenomenon as shown by magnetic measurements. The spin-crossover transition in these and related compounds is studied by differential scanning calorimetry, and the thermodynamic excess enthalpies and entropies associated with the phenomenon are derived systematically. Then the cooperative character of the spin-crossover in these materials is quantified by use of two widely used models, so-called Slichter and Drickamer and domain models. The same procedure is applied to spin-crossover curves of similar compounds available in the literature and for which calorimetric studies have been reported. The experimental thermodynamic figures, in particular the excess enthalpies, are shown to be clearly correlated to the output parameters of both models, thus providing a direct, experimental, quantitative measure of the cooperative character of the spin-crossover phenomenon. PMID:21381636

  9. Exploring the comparative binding aspects of benzophenanthridine plant alkaloid chelerythrine with RNA triple and double helices: a spectroscopic and calorimetric approach.

    PubMed

    Haque, Lucy; Pradhan, Ankur Bikash; Bhuiya, Sutanwi; Das, Suman

    2015-07-14

    A comparative study on the interaction of a benzophenanthridine alkaloid chelerythrine (CHL) with RNA triplex poly(U).poly(A)*poly(U) (hereafter U.A*U, .(dot) and *(asterisk) represent Watson-Crick and Hoogsteen base pairing respectively) and its parent duplex poly(A).poly(U) (A.U) was carried out by using a combination of various spectroscopic, viscometric and calorimetric techniques. The interaction was characterized by hypochromic and bathochromic effects in the absorption spectrum, the increase of thermal melting temperature, enhancement in solution viscosity, and perturbation in the circular dichroic spectrum. The binding constant calculated by using spectrophotometric data was in the order of 10(5) for both forms of RNA, but it was greater for triplex RNA (30.2 × 10(5) M(-1)) than duplex RNA (3.6 × 10(5) M(-1)). Isothermal titration calorimetric data are in good agreement with the spectrophotometric data. The data indicated stronger binding of CHL to the triplex structure of RNA compared to the native duplex structure. Thermal melting studies indicated greater stabilization of the Hoogsteen base paired third strand of the RNA triplex compared to its Watson-Crick strands. The mode of binding of CHL to both U.A*U and A.U was intercalation as revealed from fluorescence quenching, viscosity measurements and sensitization of the fluorescence experiment. Thermodynamic data obtained from isothermal calorimetric measurements revealed that association was favoured by both a negative enthalpy change and a positive entropy change. Taken together, our results suggest that chelerythrine binds and stabilizes the RNA triplex more strongly than its respective parent duplex. The results presented here may be useful for formulating effective antigene strategies involving benzophenanthridine alkaloids and the RNA triplex. PMID:26073991

  10. Trophic relay and prey switching - A stomach contents and calorimetric investigation of an ambassid fish and their saltmarsh prey

    NASA Astrophysics Data System (ADS)

    McPhee, Jack J.; Platell, Margaret E.; Schreider, Maria J.

    2015-12-01

    Trophic relay is an ecological model that involves the movement of biomass and energy from vegetation, such as saltmarshes, within estuaries to the open sea via a series of predator-prey relationships. Any potential for trophic relay is therefore affected by water movements within an estuary and by the ability of a predator to "switch" prey in response to fluctuating abundances of those prey. Saltmarsh-dwelling grapsid crabs, which feed on saltmarsh-derived detritus and microphytobenthos, release zoeae into ebbing tides that inundate saltmarshes during spring-tide cycles within tidally-dominated estuaries, such as Brisbane Water Estuary, therefore providing an opportunity to examine whether prey-switching and/or trophic relay may occur in fish that feed on those zoeae (such as the highly abundant estuarine ambassid, Ambassis jacksoniensis). This model was examined by sampling A. jacksoniensis near saltmarshes in a large, temperate south-eastern Australian estuary during flood and ebb tides on days of saltmarsh inundation and non-inundation over four spring-tide events in 2012. Stomach fullnesses of A. jacksoniensis were generally highest during ebb tides on days of saltmarsh inundation, implying that feeding was most marked at these times. Caridean decapods dominated diets during flood tides and on days of no saltmarsh inundation, while crab zoeae dominated diets during ebb tides and on days of inundation, suggesting that, when saltmarsh-derived zoeae became abundant, A. jacksoniensis switched to feeding on those prey. Three potential zooplankton prey (calanoid copepods, caridean decapods and crab zoeae) did not differ calorimetrically, indicating that switching of prey by A. jacksoniensis is not directly related to their preying on energetically greater prey, but reflects opportunistic feeding on more abundant and/or less elusive prey. As A. jacksoniensis is able to switch prey from estuarine caridean decapods to saltmarsh-derived crab zoeae, this very abundant

  11. Calorimetric and acoustic emission study of martensitic transformation in single-crystalline Ni2MnGa alloys

    NASA Astrophysics Data System (ADS)

    Tóth, László Z.; Szabó, Sándor; Daróczi, Lajos; Beke, Dezső L.

    2014-12-01

    The jerky character of austenite-martensite phase transformation in Ni2MnGa single crystals (with 10M martensite structure) has been investigated by thermal cycling using a differential scanning calorimeter (DSC) and by detection of acoustic emissions (AEs) at low cooling and heating rates (0.1 K/min and below). It is illustrated that, besides the low cooling and heating rate, mass and surface roughness are also important parameters in optimizing the best signal/noise ratio in order to obtain individual peaks suitable for statistical analysis. Three types of samples, differing in the twin structure and twin boundary behavior, were investigated with and without surface roughening made by electro-erosion. The statistical analysis, carried out for both (thermal and acoustic) types of signals, provided power-law behavior. In calorimetric measurements the energy exponents, obtained in cooling, were the same within the experimental errors (ɛ =1.7 ±0.2 ) for the three samples investigated. In acoustic emission experiments the energy and amplitude, α , exponents were determined both for cooling and heating. The exponents for cooling and heating runs are slightly different. They are larger for heating for both α and ɛ , in accordance with the asymmetric acoustic activity: we observed higher acoustic activity (higher number of hits) during cooling. The effect of the surface roughness is negligible in the exponents (but higher acoustic activity corresponds to higher roughness) and the following values were obtained: ɛ =1.5 ±0.1 and α =2.1 ±0.1 for cooling as well as ɛ =1.8 ±0.1 and α =2.6 ±0.1 for heating. Our results are in accordance with the results of Gallardo et al. [Phys. Rev. B 81, 174102 (2010), 10.1103/PhysRevB.81.174102] obtained in Cu based alloys: the exponents of the energy distributions, for both DSC and AE signals, were the same within the experimental errors. Furthermore, our exponents obtained from the AE measurements are close to the values

  12. Prejudice: From Allport to DuBois.

    ERIC Educational Resources Information Center

    Gaines, Stanley O., Jr.; Reed, Edward S.

    1995-01-01

    Examines the differences between Gordon Allport's and W. E. B. DuBois's theories on the origins of prejudice and the impact of discrimination on the personality and social development of blacks. The article argues that prejudice is a historically developed process, not a universal feature of human psychology. Implications for U.S. race relations…

  13. Sign Communication in Cri du Chat Syndrome

    ERIC Educational Resources Information Center

    Erlenkamp, Sonja; Kristoffersen, Kristian Emil

    2010-01-01

    This paper presents findings from a study on the use of sign supported Norwegian (SSN) in two individuals with Cri du chat syndrome (CCS). The study gives a first account of some selected aspects of production and intelligibility of SSN in CCS. Possible deviance in manual parameters, in particular inter- and/or intra-subject variation in the use…

  14. Micromechanical calorimetric sensor

    DOEpatents

    Thundat, Thomas G.; Doktycz, Mitchel J.

    2000-01-01

    A calorimeter sensor apparatus is developed utilizing microcantilevered spring elements for detecting thermal changes within a sample containing biomolecules which undergo chemical and biochemical reactions. The spring element includes a bimaterial layer of chemicals on a coated region on at least one surface of the microcantilever. The chemicals generate a differential thermal stress across the surface upon reaction of the chemicals with an analyte or biomolecules within the sample due to the heat of chemical reactions in the sample placed on the coated region. The thermal stress across the spring element surface creates mechanical bending of the microcantilever. The spring element has a low thermal mass to allow detection and measuring of heat transfers associated with chemical and biochemical reactions within a sample placed on or near the coated region. A second surface may have a different material, or the second surface and body of microcantilever may be of an inert composition. The differential thermal stress between the surfaces of the microcantilever create bending of the cantilever. Deflections of the cantilever are detected by a variety of detection techniques. The microcantilever may be approximately 1 to 200 .mu.m long, approximately 1 to 50 .mu.m wide, and approximately 0.3 to 3.0 .mu.m thick. A sensitivity for detection of deflections is in the range of 0.01 nanometers. The microcantilever is extremely sensitive to thermal changes in samples as small as 30 microliters.

  15. Calorimetric system and method

    DOEpatents

    Gschneidner, K.A. Jr.; Pecharsky, V.K.; Moorman, J.O.

    1998-09-15

    Apparatus is described for measuring heat capacity of a sample where a series of measurements are taken in succession comprises a sample holder in which a sample to be measured is disposed, a temperature sensor and sample heater for providing a heat pulse thermally connected to the sample, and an adiabatic heat shield in which the sample holder is positioned and including an electrical heater. An electrical power supply device provides an electrical power output to the sample heater to generate a heat pulse. The electrical power from a power source to the heat shield heater is adjusted by a control device, if necessary, from one measurement to the next in response to a sample temperature-versus-time change determined before and after a previous heat pulse to provide a subsequent sample temperature-versus-time change that is substantially linear before and after the subsequent heat pulse. A temperature sensor is used and operable over a range of temperatures ranging from approximately 3K to 350K depending upon the refrigerant used. The sample optionally can be subjected to dc magnetic fields such as from 0 to 12 Tesla (0 to 120 kOe). 18 figs.

  16. Calorimetric system and method

    DOEpatents

    Gschneidner, Jr., Karl A.; Pecharsky, Vitalij K.; Moorman, Jack O.

    1998-09-15

    Apparatus for measuring heat capacity of a sample where a series of measurements are taken in succession comprises a sample holder in which a sample to be measured is disposed, a temperature sensor and sample heater for providing a heat pulse thermally connected to the sample, and an adiabatic heat shield in which the sample holder is positioned and including an electrical heater. An electrical power supply device provides an electrical power output to the sample heater to generate a heat pulse. The electrical power from a power source to the heat shield heater is adjusted by a control device, if necessary, from one measurement to the next in response to a sample temperature-versus-time change determined before and after a previous heat pulse to provide a subsequent sample temperature-versus-time change that is substantially linear before and after the subsequent heat pulse. A temperature sensor is used and operable over a range of temperatures ranging from approximately 3K to 350K depending upon the refrigerant used. The sample optionally can be subjected to dc magnetic fields such as from 0 to 12 Tesla (0 to 120 kOe).

  17. Calorimetric Study of Phase Stability and Phase Transformation in U- xZr ( x = 2, 5, 10 wt pct) Alloys

    NASA Astrophysics Data System (ADS)

    Rai, Arun Kumar; Subramanian, Raju; Hajra, Raj Narayan; Tripathy, Haraprasanna; Rengachari, Mythili; Saibaba, Saroja

    2015-11-01

    A comprehensive calorimetric study of high-temperature phase equilibria and phase transformation characteristics in U- xZr ( x = 2, 5, 10 wt pct) alloys has been undertaken, as a function of heating and cooling rates. It is found that the following sequence of phase transformation takes place upon slow heating in annealed U-2 wt pct Zr alloy: α + α' + δ-UZr2 → α + γ 2 → β + γ 2 → β + γ 1 → γ. For alloys of 5 and 10 wt pct Zr, the additional presence of a miscibility gap ( γ 1 U-rich bcc + γ 2 Zr-rich bcc) in the high-temperature γ(bcc) phase region resulted in the following transformation sequence: α + α' + δ-UZr2 → α + γ 2 → β + γ 2 → γ 1 + γ 2 → γ. Further, it has been demonstrated that depending on the nature of starting microstructure, namely whether it is α eq + δ-UZr2, or a mix of α' + α eq + δ-UZr2 phases, the relative extents of two possible co-occurring modes of the first on-heating phase transformation step differ. In case of starting microstructure having mixture of three phases α' + α eq + δ-UZr2, it is found that α'-martensite relaxation via α' + α eq + δ-UZr2 → α eq + δ-UZr2 constitutes the first on-heating thermal response. The α'-martensitic relaxation is very closely followed by the dissolution of δ-UZr2. The co-occurrence of these two events gives rise to a composite thermal arrest in a normal dynamic calorimetry profile. However, if the starting microstructure is the one having the equilibrium mix of α eq and δ-UZr2, then only the peritectoidal dissolution of δ-UZr2 is found in the calorimetry profile. Unless, a very slow cooling rate of the order of 0.1 K min-1 is adopted from high-temperature γ(bcc) phase, it is not possible to obtain 100 pct of α eq phase along with equilibrium amount of δ-UZr2. At normal and high cooling rates, it is possible to suppress the diffusional decomposition of γ to varying extents. The direct γ → α'-martensite transformation has been observed at

  18. [Brief discussion on "Sanli acupoint for du-fu diseases"].

    PubMed

    Zhou, Li; He, Quan; Xin, Yu; Zhang, Hongxing

    2015-07-01

    The connotations of "du-fu" and "Sanli" in "Sanli acupoint for du-fu diseases" are discussed in this paper, which can provide theoretical foundation for the clinical application of "Sanli acupoint for du-fu diseases". Based on ancient literature combined with related theories in the Huangdi Neijing (Yellow Emperor's Canon of Internal Classic), a deep discussion is performed through the relationship between Zusanli (ST 36) and stomach, indication and mechanism of Zusanli (ST 36) on du-fu diseases and comparison between Zusanli (ST 36) and Shousanli (LI 10). It is believed that "du" should be pronounced as "dŭ", meaning stomach, and it indicates that Zusanli (ST 36) is closely related to stomach and spleen when it is used for du-fu diseases; "fu" means abdomen area, including liver-gallbladder, spleen, stomach-intestine, kidney, uterus, triple energizer; "sanli' means exclusively the acupoint of Zusanli (ST 36). PMID:26521594

  19. A spectroscopic and calorimetric study of the melting behaviors of a "bent" and a "normal" DNA duplex: [d(GA4T4C)]2 versus [d(GT4A4C)]2.

    PubMed Central

    Park, Y W; Breslauer, K J

    1991-01-01

    We have calorimetrically detected and energetically characterized a premelting event in the "bent" duplex [d(GA4T4C)]2 that is absent in the "normal" duplex [d(GT4A4C)]2. This premelting may correspond to the thermally induced "unbending" of the duplex. Specifically, we have used a combination of spectroscopic and calorimetric techniques to evaluate whether differences in the electrophoretic and hydrogen exchange properties of the bent duplex, [d(GA4T4C)]2, and the normal duplex, [d(GT4A4C)]2, are paralleled by differences in the equilibrium melting properties of these duplexes. Our results reveal that the bimolecular global meltings of both duplexes exhibit two-state behavior and are characterized by the expected thermodynamic changes, as well as the expected salt-dependencies. Significantly, however, at temperatures below duplex melting and over a similar temperature range in which the aberrant electrophoretic mobility is observed (approximately less than 35 degrees C), the bent duplex exhibits calorimetric premelting behavior absent in the normal duplex. Analysis of the calorimetric data in this preglobal melting domain (approximately less than 35 degrees C) allows us to estimate a lower-limit value of 1.6 kcal/(mol-base pair) for the thermally induced unbending of the decameric duplex. PMID:1996356

  20. Sustainable growth, the DuPont way.

    PubMed

    Holliday, C

    2001-09-01

    Like many manufacturers, DuPont traditionally has grown by making more and more "stuff." And its business growth has been proportional to the amount of raw materials and energy used--as well as the resulting waste and emissions from operations. Over the years, though, DuPont became aware that cheap supplies of nonrenewable resources wouldn't be endlessly available and that the earth's ecosystems couldn't indefinitely absorb the waste and emissions of production and consumption. Chad Holliday, chairman and CEO of DuPont, believes strongly in the challenge of sustainable growth and makes the business case for it: By using creativity and scientific knowledge effectively, he says, companies can provide strong returns for shareholders and grow their businesses--while also meeting the human needs of societies around the world and reducing the environmental footprint of their operations and products. In fact, a focus on sustainability can help identify new products, markets, partnerships, and intellectual property and lead to substantial business growth. Holliday describes how DuPont developed a three-pronged strategy to translate the concept of sustainability into nuts-and-bolts business practices. Focusing on integrated science, knowledge intensity, and productivity improvement, the strategy was accompanied by a new way to measure progress quantitatively. Sustainable growth should be viewed not as a program for stepped-up environmental performance but as a comprehensive way of doing business, one that delivers tremendous economic value and opens up new opportunities. Ultimately, companies will find that they can generate substantial business value through sustainability while both enhancing the quality of life around the world and protecting the environment. PMID:11550629

  1. Du Pont Classifications of 6 Supernovae

    NASA Astrophysics Data System (ADS)

    Morrell, N.; Shappee, Benjamin J.

    2016-06-01

    We report optical spectroscopy (range 370-910 nm) of six supernovae from the Backyard Observatory Supernova Search (BOSS) and the All-Sky Automated Survey for Supernovae (ASAS-SN) using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory on June 17 2016 UT. We performed a cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, Ap.J.

  2. Cloning and sequencing of Duck circovirus (DuCV).

    PubMed

    Hattermann, K; Schmitt, C; Soike, D; Mankertz, A

    2003-12-01

    The genome of Duck circovirus (DuCV) is circular and 1996 nts in size. Two major open reading frames were identified, encoding the replicase (V1) and the capsid protein (C1). A stem-loop structure comprising the nonamer 5'-TATTATTAC, conserved in all circo-, nano- and geminiviruses, was found. Unique to DuCV, the region between the 3'-ends of the rep and cap gene contains four repeats of a 44-bp sequence. Phylogenetic analysis shows close relation of DuCV with Goose circovirus and suggests classification of DuCV as a new member of the genus Circovirus of the virus family Circoviridae. PMID:14648300

  3. Development of a new type of high pressure calorimetric cell, mechanically agitated and equipped with a dynamic pressure control system: Application to the characterization of gas hydrates

    SciTech Connect

    Plantier, F. Missima, D.; Torré, J.-P.; Marlin, L.

    2013-12-15

    A novel prototype of calorimetric cell has been developed allowing experiments under pressure with an in situ agitation system and a dynamic control of the pressure inside the cell. The use of such a system opens a wide range of potential practical applications for determining properties of complex fluids in both pressurized and agitated conditions. The technical details of this prototype and its calibration procedure are described, and an application devoted to the determination of phase equilibrium and phase change enthalpy of gas hydrates is presented. Our results, obtained with a good precision and reproducibility, were found in fairly good agreement with those found in literature, illustrate the various interests to use this novel apparatus.

  4. Calorimetric Studies of the Energetics of Order-Disorder in the System Mg(1-x)Fe(x)Ca(CO(3))(2)

    SciTech Connect

    Brady, P.; Dooley, D.; Navrotsky, A.; Reeder, R.

    1999-02-10

    Calorimetric studies by Chai and Navrotsky (1996) on dolomite-ankerite energetic have been extended by including two additional types of samples: a very disordered stoichiometric MgCa(CO{sub 3}){sub 2} prepared from low temperature aqueous solution and three largely ordered natural samples of intermediate iron content. Combining these data with previous work, three distinct trends of energetic can be seen: those for samples with nearly complete order, nearly complete disorder, and intermediate order. From these trends, the enthalpy of complete disordering is estimated to be 33 {+-} 6 kJ/mol for MgCa(CO{sub 3}){sub 2} and 18 {+-} 5 kJ/mol for FeCa(CO{sub 3}){sub 2}.

  5. A Search for Low-Mass Weakly Interacting Massive Particles Using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment

    SciTech Connect

    Agnese, R.; Anderson, A. J.; Asai, M.; Balakishiyeva, D.; Basu Thakur, R.; Bauer, D. A.; Billard, J.; Borgland, A.; Bowles, M. A.; Brandt, D.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Cerdeno, D. G.; Chagani, H.; Cooley, J.; Cornell, B.; Crewdson, C. H.; Cushman, Priscilla B.; Daal, M.; Di Stefano, P. C.; Doughty, T.; Esteban, L.; Fallows, S.; Figueroa-Feliciano, E.; Godfrey, G. L.; Golwala, S. R.; Hall, Jeter C.; Harris, H. R.; Hertel, S. A.; Hofer, T.; Holmgren, D.; Hsu, L.; Huber, M. E.; Jastram, A.; Kamaev, O.; Kara, B.; Kelsey, M. H.; Kennedy, A.; Kiveni, M.; Koch, K.; Loer, B.; Lopez Asamar, E.; Mahapatra, R.; Mandic, V.; Martinez, C.; McCarthy, K. A.; Mirabolfathi, N.; Moffatt, R. A.; Moore, D. C.; Nadeau, P.; Nelson, R. H.; Page, K.; Partridge, R.; Pepin, M.; Phipps, A.; Prasad, K.; Pyle, M.; Qiu, H.; Rau, W.; Redi, P.; Reisetter, A.; Ricci, Y.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, Richard; Scorza, S.; Serfass, B.; Shank, B.; Speller, D.; Villano, A. N.; Welliver, B.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, J.

    2014-01-27

    SuperCDMS is an experiment designed to directly detect weakly interacting massive particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this Letter, we present WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage-assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for ten live days at the Soudan Underground Laboratory. A low energy threshold of (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV/c2.

  6. Search for Low-Mass Weakly Interacting Massive Particles Using Voltage-Assisted Calorimetric Ionization Detection in the SuperCDMS Experiment

    NASA Astrophysics Data System (ADS)

    Agnese, R.; Anderson, A. J.; Asai, M.; Balakishiyeva, D.; Basu Thakur, R.; Bauer, D. A.; Billard, J.; Borgland, A.; Bowles, M. A.; Brandt, D.; Brink, P. L.; Bunker, R.; Cabrera, B.; Caldwell, D. O.; Cerdeno, D. G.; Chagani, H.; Cooley, J.; Cornell, B.; Crewdson, C. H.; Cushman, P.; Daal, M.; Di Stefano, P. C. F.; Doughty, T.; Esteban, L.; Fallows, S.; Figueroa-Feliciano, E.; Godfrey, G. L.; Golwala, S. R.; Hall, J.; Harris, H. R.; Hertel, S. A.; Hofer, T.; Holmgren, D.; Hsu, L.; Huber, M. E.; Jastram, A.; Kamaev, O.; Kara, B.; Kelsey, M. H.; Kennedy, A.; Kiveni, M.; Koch, K.; Loer, B.; Lopez Asamar, E.; Mahapatra, R.; Mandic, V.; Martinez, C.; McCarthy, K. A.; Mirabolfathi, N.; Moffatt, R. A.; Moore, D. C.; Nadeau, P.; Nelson, R. H.; Page, K.; Partridge, R.; Pepin, M.; Phipps, A.; Prasad, K.; Pyle, M.; Qiu, H.; Rau, W.; Redl, P.; Reisetter, A.; Ricci, Y.; Saab, T.; Sadoulet, B.; Sander, J.; Schneck, K.; Schnee, R. W.; Scorza, S.; Serfass, B.; Shank, B.; Speller, D.; Villano, A. N.; Welliver, B.; Wright, D. H.; Yellin, S.; Yen, J. J.; Young, B. A.; Zhang, J.; SuperCDMS Collaboration

    2014-01-01

    SuperCDMS is an experiment designed to directly detect weakly interacting massive particles (WIMPs), a favored candidate for dark matter ubiquitous in the Universe. In this Letter, we present WIMP-search results using a calorimetric technique we call CDMSlite, which relies on voltage-assisted Luke-Neganov amplification of the ionization energy deposited by particle interactions. The data were collected with a single 0.6 kg germanium detector running for ten live days at the Soudan Underground Laboratory. A low energy threshold of 170 eVee (electron equivalent) was obtained, which allows us to constrain new WIMP-nucleon spin-independent parameter space for WIMP masses below 6 GeV /c2.

  7. Calorimetric determination of the magnetic phase diagram of underdoped ortho II YBa2Cu3O6.54 single crystals

    PubMed Central

    Marcenat, C.; Demuer, A.; Beauvois, K.; Michon, B.; Grockowiak, A.; Liang, R.; Hardy, W.; Bonn, D. A.; Klein, T.

    2015-01-01

    The recent discovery of a charge order in underdoped YBa2Cu3Oy raised the question of the interplay between superconductivity and this competing phase. Understanding the normal state of high-temperature superconductors is now an essential step towards the description of the pairing mechanism in those materials and determining the upper critical field is therefore of fundamental importance. We present here a calorimetric determination of the field–temperature phase diagram in underdoped YBa2Cu3Oy single crystals. We show that the specific heat saturates in high magnetic fields. This saturation is consistent with a normal state without any significant superconducting contribution and a total Sommerfeld coefficient γN∼6.5±1.5 mJ mol−1 K−2 putting strong constraints on the theoretical models for the Fermi surface reconstruction. PMID:26294047

  8. Thermodynamic properties of illite, smectite and beidellite by calorimetric methods: Enthalpies of formation, heat capacities, entropies and Gibbs free energies of formation

    NASA Astrophysics Data System (ADS)

    Gailhanou, H.; Blanc, P.; Rogez, J.; Mikaelian, G.; Kawaji, H.; Olives, J.; Amouric, M.; Denoyel, R.; Bourrelly, S.; Montouillout, V.; Vieillard, P.; Fialips, C. I.; Michau, N.; Gaucher, E. C.

    2012-07-01

    The thermodynamic properties of three aluminous 2:1 clay minerals were acquired at 1.013 bars and at temperatures between 5 and 500 K using various calorimetric methods. Calorimetric measurements were performed on hydrated and dehydrated <2 μm clay fractions of smectite MX-80 (Wyoming), illite IMt-2 (Silver Hill) and beidellite SBId-1 (Black Jack Mine). After purification, the mineralogical analyses gave the following structural formulae: Na0.409K0.024Ca0.009 (Si3.738Al0.262) (Al1.598Mg0.214Fe 0.173 3 + Fe 0.035 2 +)O10(OH)2,K0.762Na0.044 (Si3.387Al0.613) (Al1.427Mg0.241Fe 0.292 3 + Fe 0.084 2 +)O10(OH)2 and Ca0.185K0.104 (Si3.574Al0.426) (Al1.812Mg0.09Fe 0.112 3 +)O10(OH)2 for smectite MX-80, illite IMt-2 and beidellite SBId-1, respectively. Heat capacities were measured by low temperature adiabatic calorimetry and differential scanning calorimetry, from 5 to 500 K. Standard enthalpies of formation were obtained from solution-reaction calorimetry at 298.15 K. The standard Gibbs free energies of formation of the clay minerals were also calculated, together with the equilibrium constants at 25 °C, for anhydrous and hydrated minerals. A comparison between these experimental data and estimated values obtained from prediction models available in the literature, enabled the calculation method that appears to be the most relevant to be selected, at least for aluminous 2:1 clay minerals.

  9. La reconstruction du sourcil par greffon composite du cuir chevelu: une astuce pour faciliter la technique

    PubMed Central

    El Omari, Mounia; El Mazouz, Samir; Gharib, Noureddine; EL Abbassi, Abdallah

    2015-01-01

    Les sourcils jouent un rôle important dans l’équilibre esthétique du visage. Leur reconstruction ou ophriopoïése, après séquelle de brûlure fait partie intégrante du programme de réhabilitation de la face brûlée. Plusieurs techniques ont été décrites. Nous insistons ici sur l'intérêt d'une technique simple, à la portée de tous les chirurgiens, et dont la méthode et les résultats peuvent être améliorés par un dessin bien planifié des zones donneuse et receveuse: la greffe composite prélevée au niveau du cuir chevelu dessinée à l'aide d'un calque du sourcil controlatéral. PMID:26401195

  10. 76 FR 68124 - Television Broadcasting Services; Fond du Lac, WI

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-03

    ... reconsideration of an August 12, 2009 Report and Order changing the allotted channel for station WWAZ-TV, Fond du... 5 for channel 44 at Fond du Lac ] because it permitted WLS-TV, an ABC network affiliate in Chicago... network service to numerous viewers that had lost service after the transition of WLS-TV to...

  11. 33 CFR 117.443 - Du Large Bayou.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 1 2010-07-01 2010-07-01 false Du Large Bayou. 117.443 Section 117.443 Navigation and Navigable Waters COAST GUARD, DEPARTMENT OF HOMELAND SECURITY BRIDGES DRAWBRIDGE OPERATION REGULATIONS Specific Requirements Louisiana § 117.443 Du Large Bayou. The draw of...

  12. Oncoplastie avec conservation mammaire dans le traitement du cancer du sein: à propos de 16 cas

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryam; Jayi, Sofia; Alaoui, Fatime Zahra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2015-01-01

    Le cancer du sein est actuellement le cancer le plus fréquent chez la femme, et pose un véritable problème diagnostique et thérapeutique. Le dépistage des lésions à un stade de plus en plus précoce, a permis une extension des indications du traitement conservateur radiochirurgical, qui était initialement limitées aux tumeurs de moins de 3 cm, unifocales, non inflammatoires. Par ailleurs, l'utilisation de traitements préopératoires permet d’étendre les indications du traitement conservateur à des tumeurs plus volumineuses. Parallèlement à cette extension des indications de conservation mammaire, on a observé le développement de nouvelles approches thérapeutiques notamment la chirurgie oncoplastique, technique du ganglion sentinelle et chirurgie stéréotaxique, dont les résultats initiaux sont très encouragent. A travers cette étude réalisée dans le service de gynécologie et obstétrique II du CHU HASSAN II de FES au MAROC, après l'analyse rétrospective de 16 patientes traitées par traitement conservateur et oncoplastie, nous avons voulus montrer notre aptitude a réalisé ses techniques chirurgicales et a bien prendre en charge ces patientes, mais aussi évaluer ces techniques en termes de résultat carcinologique et de résultat esthétique, aussi en terme de survie globale, survie sans métastase et en termes de récidive locale entre les plasties mammaires et les traitements usuels: mastectomie et traitement conservateur classique. PMID:26430477

  13. Modelisation par elements finis du muscle strie

    NASA Astrophysics Data System (ADS)

    Leonard, Mathieu

    Ce present projet de recherche a permis. de creer un modele par elements finis du muscle strie humain dans le but d'etudier les mecanismes engendrant les lesions musculaires traumatiques. Ce modele constitue une plate-forme numerique capable de discerner l'influence des proprietes mecaniques des fascias et de la cellule musculaire sur le comportement dynamique du muscle lors d'une contraction excentrique, notamment le module de Young et le module de cisaillement de la couche de tissu conjonctif, l'orientation des fibres de collagene de cette membrane et le coefficient de poisson du muscle. La caracterisation experimentale in vitro de ces parametres pour des vitesses de deformation elevees a partir de muscles stries humains actifs est essentielle pour l'etude de lesions musculaires traumatiques. Le modele numerique developpe est capable de modeliser la contraction musculaire comme une transition de phase de la cellule musculaire par un changement de raideur et de volume a l'aide des lois de comportement de materiau predefinies dans le logiciel LS-DYNA (v971, Livermore Software Technology Corporation, Livermore, CA, USA). Le present projet de recherche introduit donc un phenomene physiologique qui pourrait expliquer des blessures musculaires courantes (crampes, courbatures, claquages, etc.), mais aussi des maladies ou desordres touchant le tissu conjonctif comme les collagenoses et la dystrophie musculaire. La predominance de blessures musculaires lors de contractions excentriques est egalement exposee. Le modele developpe dans ce projet de recherche met ainsi a l'avant-scene le concept de transition de phase ouvrant la porte au developpement de nouvelles technologies pour l'activation musculaire chez les personnes atteintes de paraplegie ou de muscles artificiels compacts pour l'elaboration de protheses ou d'exosquelettes. Mots-cles Muscle strie, lesion musculaire, fascia, contraction excentrique, modele par elements finis, transition de phase

  14. Continuous improvement journey at Du Pont photomasks

    NASA Astrophysics Data System (ADS)

    Henderson, Robert K.

    1994-02-01

    This paper describes the history and experiences of Du Pont Photomasks in their efforts to integrate the continuous improvement philosophy and practices embodied in the Malcolm Baldrige National Quality Award criteria into their way of doing business. A case study of key learnings in this almost four year long process is presented. Specific topics discussed include the process applied to achieve ISO 9000 certification, the quality systems deployed in this effort, and the use of a balanced set of business and quality metrics to assess and improve upon performance.

  15. La fin du jeûne?

    PubMed Central

    Naugler, Christopher; Sidhu, Davinder

    2014-01-01

    Résumé Objectif Présenter une mise à jour sur l’utilité clinique de ne pas être à jeun par rapport à l’être pour l’analyse des lipides dans le but d’améliorer l’observance par les patients, leur sécurité et l’évaluation clinique dans les tests du cholestérol. Qualité des données Les recommandations sont classées comme étant fondées sur des données probantes fortes, acceptables ou faibles (conflictuelles ou insuffisantes), selon les classifications adoptées par le Groupe d’étude canadien sur les soins de santé préventifs. Message principal Le dépistage de la dyslipidémie comme facteur de risque de coronaropathie et la prescription de médicaments hypolipidémiants sont des activités importantes en soins primaires. De récentes données probantes remettent en question la nécessité d’être à jeun pour la mesure des lipides. Dans des études sur la population, le cholestérol total, le cholestérol à lipoprotéines de haute densité et le cholestérol à lipoprotéines autres qu’à haute densité variaient tous d’en moyenne 2 % à jeun. Pour un dépistage de routine, la mesure du cholestérol sans être à jeun est maintenant une option de rechange raisonnable à l’analyse à jeun. Pour les patients diabétiques, l’exigence d’être à jeun peut représenter un important problème de sécurité en raison des possibilités d’hypoglycémie. Pour la surveillance des triglycérides et du cholestérol à lipoprotéines de basse densité chez les patients qui prennent des médicaments hypolipidémiants, le jeûne devient important. Conclusion Être à jeun pour la détermination routinière des niveaux lipidiques est largement inutile et il est improbable que le jeûne influence la stratification du risque clinique chez le patient, tandis que la mesure sans être à jeun pourrait améliorer l’observance par le patient et sa sécurité.

  16. Mesure du taux de la capture radiative du muon par l'hydrogene liquide

    NASA Astrophysics Data System (ADS)

    Jonkmans, Guy

    À basse énergie, l'interaction faible entre leptons et quarks est décrite par une interaction de la forme courant × courant de type V - A. La présence de l'interaction forte induit des couplages additionnels qui doivent être déterminés expérimentalement. De ceux-ci, le couplage pseudoscalaire induit, gp , est mesuré avec la plus grande incertitude et fait l'objet de la présente recherche. L'hypothèse du Courant Axial Partiellement Conservé (CAPC) et l'usage de la relation de Goldberger-Treiman relie gp au couplage axial ga . Cette relation a été vérifiée traditionnellement par la Capture Ordinaire du Muon (COM) à une valeur fixe du moment de transfert q. La Capture Radiative du Muon (CRM), m- p-->nnmg , est un meilleur outil pour l'étude de gp à cause de sa dépendance variable en q2 qui offre une plus grande sensibilité dans la partie à haute énergie du spectre des photons. Toutefois, le petit rapport d'embranchement (~10-8) de la CRM par rapport à la désintégration du muon a retardé cette mesure jusqu'à ce jour. La théorie et les difficultés expérimentales associées à la détection des photons de CRM sont présentées au deuxième chapitre. On décrit ensuite, au troisième chapitre, les composantes du système de détection. Ce détecteur est un spectromètre à paires de grand angle solide (~3p) et qui permet l'observation des photons par l'analyse des électrons et des positrons de photo-conversion. Ainsi, le bruit de fond important des neutrons de la COM ne constitue pas un problème pour cette mesure. Nous décrivons, au quatrième chapitre, toutes les étapes de l'analyse, nécessaires pour la réduction des multiples bruits de fond. Le cinquième chapitre présente le calcul des efficacités ainsi que l'estimation des erreurs systématiques. Le sixième chapitre démontre comment l'on extrait le rapport d'embranchement pour la CRM ainsi que la valeur ae gp . On insiste sur la dépendance de gp en fonction de la valeur de

  17. The Pic du Midi solar survey

    NASA Astrophysics Data System (ADS)

    Koechlin, L.

    2015-12-01

    We carry a long term survey of the solar activity with our coronagraphic system at Pic du Midi de Bigorre in the French Pyrenees (CLIMSO). It is a set of two solar telescopes and two coronagraphs, taking one frame per minute for each of the four channels : Solar disk in H-α (656.28 nm), prominences in H-α, disk in Ca II (393.3 nm), prominences in He I (1083 nm), all year long, weather permitting. Since 2015 we also take images of the FeXIII corona (1074.7 nm) at the rate of one every 10 minutes. These images cover a large field: 1.25 solar diameter, 2k*2K pixels, and are freely downloadable form a database. The improvements made since 2015 concern an autoguiding system for better centering of the solar disk behind the coronagraphic masks, and a new Fe XIII channel at λ=1074.7 nm. In the near future we plan to provide radial velocity maps of the disc and polarimetry maps of the disk and corona. This survey took its present form in 2007 and we plan to maintain image acquisition in the same or better experimental conditions for a long period: one or several solar cycles if possible. During the partial solar eclipse of March 20, 2015, the CLIMSO instruments and the staff at Pic du Midi operating it have provided several millions internet users with real time images of the Sun and Moon during all the phenomenon.

  18. Élimination du bore du silicium par plasma inductif sous champ électrique

    NASA Astrophysics Data System (ADS)

    Combes, R.; Morvan, D.; Picard, G.; Amouroux, J.

    1993-05-01

    We analyzed purification mechanisms of silicon by inductive plasma with a fluoride slag. The aim is to study boron elimination from doped electronic grade silicon in function of the nature of the slag to obtain a photovoltaic grade silicon. The steady began with the calculation and the comparison of the stability diagram of boron compounds in presence of CaF2, BaF2 and MgF2. This study led us to conclude that BaF2 is the better slag for silicon purification. This has been confirmed by experience. In a second time, we made purifications under electric bias to enhance slag efficiency. We noticed that BaF2 is more sensitive to electric bias than other slags. Nous avons analysé le mécanisme de purification du silicium sous plasma inductif en présence d'un laitier fluoré. L'objectif principal est d'étudier l'élimination du bore du silicium électronique dopé en fonction de la nature du fluorure pour obtenir un silicium de qualité photovoltaïque. L'étude a commencé par l'établissement et la comparaison de diagrammes des composés du bore en présence de CaF2, de MgF2 et de BaF2. Nous avons déduit de cette première étude que BaF2 est le meilleur laitier pour la purification du silicium. Ceci a été corroboré par l'expérience. Nous avons ensuite opéré en présence d'un champ électrique dans le but d'améliorer encore l'efficacité des laitiers. Nous avons constaté que BaF2 est plus sensible au champ électrique que les deux autres laitiers utilisés.

  19. Annuaire du Bureau des longitudes - 2006

    NASA Astrophysics Data System (ADS)

    Imcce; Bureau Des Longitudes

    2005-07-01

    This annual publication provides ephemerides and data to the use of professionnal and amateur astronomers. Divided in 11 chapters it covers concordance of various calendars, explanation of fondamental astronomy and various time scales, explanation for the use of ephemerides; tables provide ephemerides (positions, rise/set/passage) of the Sun and the Moon, planets, planetary satellites, asteroids, comets, bright stars; data and explanation for the physical observation of the surface of the Sun, the Moon, and planets; chart of the sky and a list of constellations and galaxies; prediction and ephemerides for astronomical phenomenon: occultation by the moon, stellar occultations by asteroids and appulses, solar eclipses and lunar eclipses; and an additional review about a hot scientific topic, this year: "Legendre et le méridien terrestre, 200 ans après". Cette publication annuelle fournit des éphémérides et des données à l'usage des astronomes professionnels et des astronomes amateurs. Composée de 11 chapitres elle comprend les rubriques sur les différents calendriers et leurs concordance, les fêtes légales en France, les dates et décrets sur les heures légales en France métropolitaine ; une introduction à l'astronomie fondamentale et aux différentes échelles de temps, des explications sur l'utilisation des éphémérides ; des tables fournissent les éphémérides (positions, heures de lever/coucher/passage) du Soleil et de la Lune, de planètes, de satellites naturels, d'astéroïdes, de comètes, d'étoiles brillantes ; des données pour l'observation de la surface du Soleil, de la Lune, et des planètes ; des cartes du ciel ainsi qu'une liste de constellations et de galaxies ; des prédictions des phénomènes astronomiques : occultation par la Lune, occultation stellaires par des astéroïdes et appulses, éclipses de Soleil et de la Lune; la liste et les coordonnées des observatoires astronomiques les plus connus ; et enfin un cahier th

  20. Le mouvement du pôle

    NASA Astrophysics Data System (ADS)

    Bizouard, Christian

    2012-03-01

    Les variations de la rotation terrestre. En conditionnant à la fois notre vie quotidienne, notre perception du ciel, et bon nombre de phénomènes géophysiques comme la formation des cyclones, la rotation de la Terre se trouve au croisement de plusieurs disciplines. Si le phenomena se faisait uniformément, le sujet serait vite discuté, mais c'est parce que la rotation terrestre varie, même imperceptiblement pour nos sens, dans sa vitesse angulaire comme dans la direction de son axe, qu'elle suscite un grand intérêt. D'abord pour des raisons pratiques : non seulement les aléas de la rotation terrestre modi_ent à la longue les pointés astrométriques à un instant donné de la journée mais in_uencent aussi les mesures opérées par les techniques spatiales ; en consequence l'exploitation de ces mesures, par exemple pour déterminer les orbites des satellites impliqués ou pratiquer le positionnement au sol, nécessite une connaissance précise de ces variations. Plus fondamentalement, elles traduisent les propriétés globales de la Terre comme les processus physiques qui s'y déroulent, si bien qu'en analysant les causes des fluctuations observées, on dispose d'un moyen de mieux connaître notre globe. La découverte progressive des fluctuations de la rotation de la Terre a une longue histoire. Sous l'angle des techniques d'observation, trois époques se pro-celle du pointé astrométrique à l'oeil nu, à l'aide d'instruments en bois ou métalliques (quart de cercle muraux par exemple). À partir du XVIIe siècle débute l'astrométrie télescopique dont les pointés sont complétés par des datations de plus en plus précises grâce à l'invention d'horloges régulées par balancier. Cette deuxième époque se termine vers 1960, avec l'avènement des techniques spatiales : les pointés astrométriques sont délaissés au profit de la mesure ultra-précise de durées ou de fréquences de signaux électromagnétiques, grâce à l'invention des horloges

  1. Carte du Ciel, San Fernando zone

    NASA Astrophysics Data System (ADS)

    Abad, C.

    2014-06-01

    An updated summary of a future large astrometric catalogue is presented, based on the two most important astrometric projects carried out by the Real Instituto y Observatorio de la Armada de San Fernando (ROA). The goal is to make a catalogue of positions and proper motions based on ROA's Cart du Ciel (CdC) and the Astrographic Catalogue (AC) San Fernando zone plates, and the HAMC2 meridian circle catalogue. The CdC and AC plates are being reduced together to provide first-epoch positions while HAMC2 will provide second-epoch ones. New techniques have been applied, that range from using a commercial flatbed scanner to the proper reduction schemes to avoid systematics from it. Only thirty plates (out of 540) remain to be processed, due to scanning problems that are being solved.

  2. Notable Stabilization of α-Chymotrypsin by the Protic Ionic Additive, [ch][dhp]: Calorimetric Evidence for a Fine Enthalpy/Entropy Balance

    PubMed Central

    Makharadze, Maya; van Eldik, Rudi; Khoshtariya, Dimitri E.

    2014-01-01

    An impact of 0.5 to 3 M choline dihydrogen phosphate, [ch][dhp], the biotechnologically relevant ionic substance, on the thermal stability of a model globular protein, α-chymotrypsin (α-CT), has been studied exploiting the highly sensitive differential scanning calorimetry (DSC) technique. The notable overall stabilizing effect of 11 ± 2 K regarding the thermal transition (melting) temperature, Tm, has been detected. For this kind of series, for the first time, the calorimetric melting enthalpy (ΔHcal) and transition entropy (ΔSm) parameters have been determined simultaneously throughout. The first analysis indicated a two-phase impact implying (a) the initial, dramatic drop in both ΔHcal and ΔSm, obviously connected to specific, direct interaction between the [ch][dhp] components and α-CT's charged groups (within 0 to 1 mol/L [ch][dhp]), leading to the essential rearrangement of the interfacial hydrogen-bonded (HB) network; and (b) the follow-up (within 1 to 3.0 mol/L [ch][dhp]), modest changes in ΔHcal and lack of changes in ΔSm, seemingly connected with a subsequent steady strengthening of already reformed HB network, respectively. These changes, presumably, are primarily facilitated by Coulombic interactions between the [dhp] anions and solvent-exposed positively charged amino groups of α-CT.

  3. Calorimetric study of crystal growth of ice in hydrated methemoglobin and of redistribution of the water clusters formed on melting the ice.

    PubMed Central

    Sartor, G; Mayer, E

    1994-01-01

    Calorimetric studies of the melting patterns of ice in hydrated methemoglobin powders containing between 0.43 and 0.58 (g water)/(g protein), and of their dependence on annealing at subzero temperatures and on isothermal treatment at ambient temperature are reported. Cooling rates were varied between approximately 1500 and 5 K min-1 and heating rate was 30 K min-1. Recrystallization of ice during annealing is observed at T > 228 K. The melting patterns of annealed samples are characteristically different from those of unannealed samples by the shifting of the melting temperature of the recrystallized ice fraction to higher temperatures toward the value of "bulk" ice. The "large" ice crystals formed during recrystallization melt on heating into "large" clusters of water whose redistribution and apparent equilibration is followed as a function of time and/or temperature by comparison with melting endotherms. We have also studied the effect of cooling rate on the melting pattern of ice with a methemoglobin sample containing 0.50 (g water)/(g protein), and we surmise that for this hydration cooling at rates of > or = approximately 150 K min-1 preserves on the whole the distribution of water molecules present at ambient temperature. PMID:7819504

  4. Classification moléculaire du cancer du sein au Maroc

    PubMed Central

    Fouad, Abbass; Yousra, Akasbi; Kaoutar, Znati; Omar, El Mesbahi; Afaf, Amarti; Sanae, Bennis

    2012-01-01

    Introduction La classification moléculaire des cancers du sein basée sur l'expression génique puis sur le profil protéique a permis de distinguer cinq groupes moléculaires: luminal A, luminal B, Her2/neu, basal-like et non-classées. L'objectif de cette étude réalisée au CHU Hassan II de Fès est de classer 335 cancers du sein infiltrant en groupes moléculaires, puis de les corréler avec les caractéristiques clinicopathologiques. Méthodes Etude rétrospective étalée sur 45 mois, comportant 335 patientes colligées au CHU pour le diagnostic et le suivi. Les tumeurs sont analysées histologiquement et classées après une étude immunohistochimique en groupes: luminal A, luminal B, Her2+, basal-like et non-classées. Résultats 54.3% des tumeurs sont du groupe luminal A, 16% luminal B, 11.3% Her2+, 11.3% basal-like et 7% non-classées. Le groupe luminal A renferme le plus faible taux de grade III, d'emboles vasculaires ainsi que de métastases; alors que le groupe des non-classées et basal-like représentent un taux élevé de grade III, une faible proportion d'emboles vasculaires et d'envahissement ganglionnaire. Ces facteurs sont significativement élevés dans les groupes luminal B et Her2+ avec un taux de survie globale de 78% et 76% respectivement. Dans le groupe luminal A, la survie globale des patientes est élevée (87%) alors qu'elle n'est que de 49% dans le groupe des triples négatifs (basal-like et non-classés). Conclusion Le groupe luminal B est différent du luminal A et il est de pronostic péjoratif vis à vis du groupe Her2+. Les caractéristiques clinicopathologiques concordent avec le profil moléculaire donc devraient être pris en considération comme facteurs pronostiques. PMID:23396646

  5. 1. Historic American Buildings Survey, drawn by Pierre du Simitiere ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Historic American Buildings Survey, drawn by Pierre du Simitiere (papers in Philadelphia Library) DRAWING OF REDWOOD LIBRARY IN 1768. - Redwood Library, 50 Bellevue Avenue, Newport, Newport County, RI

  6. Oxidation states of uranium in DU particles from Kosovo.

    PubMed

    Salbu, B; Janssens, K; Lind, O C; Proost, K; Danesi, P R

    2003-01-01

    The oxidation states of uranium contained in depleted uranium (DU) particles were determined by synchrotron radiation based micro-XANES, applied to individual particles in soil samples collected at Ceja Mountain, Kosovo. Based on scanning electron microscopy (SEM) with XRMA prior to micro-XANES, DU particles ranging from submicrons to about 30 microm (average size: 2 microm or less) were identified. Compared to well-defined standards, all investigated DU particles were oxidized. About 50% of the DU particles were characterized as UO2, the remaining DU particles present were U3O8 or a mixture of oxidized forms (ca. 2/3 UO2, 1/3 U3O8). Since the particle weathering rate is expected to be higher for U3O8 than for UO2, the presence of respiratory U3O8 and UO2 particles, their corresponding weathering rates and subsequent remobilisation of U from DU particles should be included in the environmental or health impact assessments. PMID:12500803

  7. Tumeur du sac vitellin du testicule au stade IIIc métastatique : à propos d’un cas

    PubMed Central

    Zizi, Mohamed; Ziouziou, Imad; El Yacoubi, Souhail; Khmou, Mouna; Jahid, Ahmed; Mahassini, Najat; Karmouni, Tariq; El Khader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Iben Attya

    2014-01-01

    Résumé Les tumeurs du sac vitellin du testicule sont rares chez l’adulte. Ces tumeurs se caractérisent par un mauvais pronostic à un stade métastatique avancé. Cependant, nous rapportons, dans le présent article, le cas clinique d’un adulte de 32 ans qui présentait une tumeur du sac vitellin du testicule au stade IIIc métastatique. Ce patient a subi une orchidectomie haute, accompagnée de quatre cycles de chimiothérapie à base de bléomycine, d’étoposide et de cisplatine. Il a répondu complètement au traitement, moyennant un recul de deux ans. PMID:25295144

  8. Gibbs free energies of formation of RuO 2, IrO 2, and OsO 2: A high-temperature electrochemical and calorimetric study

    NASA Astrophysics Data System (ADS)

    O'Neill, Hugh St. C.; Nell, Johan

    1997-12-01

    The Gibbs free energies of formation of RuO 2, OsO 2 and IrO 2 have been determined by measuring the chemical potentials of oxygen (μO 2) defined by the reactions M + O 2 = MO 2, where M = Ru, Os. or Ir, using an electrochemical method with calcia-stabilized zirconia (CSZ) solid electrolytes. Measurements were attempted in the temperature ranges from ˜870 K to 1620, 1270, and 1415 K for the Ru, Os, and Ir equilibria, respectively, but inspection of the results reveals that equilibrium could not be established below ˜930 K for all three reactions. For Ru + RuO 2, the highest temperature data (above 1520 K) may be systematically affected by the onset of significant electronic conduction in the CSZ electrolyte, while the attempted measurements of the Os + OsO 2 equilibrium above 1190 K are obscured by the disproportionation of OsO 2 to gaseous Os oxides. The high temperature heat capacities at constant pressure ( Cp) of RuO 2 and IrO 2 were determined from 370 to 1070 K by differential scanning calorimetry. These data were combined with heat content measurements and low-temperature heat capacities from the literature, and fitted to an extended Maier-Kelley equation. The calorimetric data for RuO 2 and IrO 2, together with assessed data for Ru, Os, and Ir metals and estimated data for OsO 2, were used in a third law analysis of the electrochemical measurements. The values of μO 2 of the three equilibria were smoothed and filtered by the third-law analysis to yield the following equations which can be extrapolated to lower and higher temperatures as indicated: μO 2 ( Ru + RuO 2) = -324563 + 344.151 T-22.1155 T ln T (700 ⩽ T ⩽ 1800) μO 2 ( Os + OsO 2) = -300399 + 307.639 T-17.4819 T ln T (700 ⩽ T ⩽ 1500) μO 2 ( Ir + IrO 2) = -256518 + 295.854 T-15.2368 T ln T (700 ⩽ T ⩽ 1500) where μO 2 is in J mol -1, T is in K, the reference pressure for O 2 is 1 bar (10 5 Pa), and estimated accuracies are approximately 200 to 400 J mol -1. For Ru + RuO 2, the drift

  9. Thermodynamic, structural, and dynamic properties of supercooled water confined in mesoporous MCM-41 studied with calorimetric, neutron diffraction, and neutron spin echo measurements

    NASA Astrophysics Data System (ADS)

    Yoshida, Koji; Yamaguchi, Toshio; Kittaka, Shigeharu; Bellissent-Funel, Marie-Claire; Fouquet, Peter

    2008-08-01

    Thermodynamic, structural, and dynamic properties of heavy water (D2O) confined in mesoporous silica glass MCM-41 C10, C12, and C14 were investigated by differential scanning calorimetry, neutron diffraction, and neutron spin echo (NSE) measurements, respectively. The DSC data showed that no crystallization of D2O confined in C10 occurs in a temperature range between 298 and 180 K, and that crystalline ice is formed at 204 and 221 K for C12 and C14, respectively. For C10, the neutron radial distribution functions of confined D2O suggested a structural change in the supercooled state between 223 and 173 K. For C10 sample, it has been found that the tetrahedral-like water structure is partially enhanced in the central part of pores at 173 K. For all the samples, the intermediate scattering functions from the NSE measurements are fitted by the Kohlrausch-Williams-Watts stretched exponential function which implies that confined supercooled D2O exhibits a wide distribution of relaxation times. For C10, C12, and C14 samples, between 298 and 240 K, the relaxation times of supercooled D2O follow remarkably well the Vogel-Fulcher-Tamman equation; for C10 sample, below 240 K, the relaxation times of nonfreezing D2O show an Arrhenius type behavior. From the present experimental results on calorimetric, structural, and dynamic properties, it has been concluded that supercooled D2O confined in MCM-41 C10 experiences a transition from high-density to low-density hydrogen-bonded structure at around 229 K.

  10. Interaction of cationic dodecyl-trimethyl-ammonium bromide with oxy-HbGp by isothermal titration and differential scanning calorimetric studies: Effect of proximity of isoelectric point.

    PubMed

    Alves, Fernanda Rosa; Carvalho, Francisco Adriano O; Carvalho, José Wilson P; Tabak, Marcel

    2016-04-01

    In this work, isothermal titration and differential scanning calorimetric methods, in combination with pyrene fluorescence emission and dynamic light scattering have been used to investigate the interaction of dodecyltrimethylammonium bromide (DTAB) with the giant extracellular Glossoscolex paulistus hemoglobin (HbGp) in the oxy-form, at pH values around the isoelectric point (pI ≈ 5.5). Our ITC results have shown that the interaction of DTAB with the hemoglobin is more intense at pH 7.0, with a smaller cac (critical aggregation concentration) value. The increase of protein concentration does not influence the cac value of the interaction, at both pH values. Therefore, the beginning of the DTAB-oxy-HbGp premicellar aggregates formation, in the cac region, is not affected by the increase of protein concentration. HSDSC studies show higher Tm values at pH 5.0, in the absence and presence of DTAB, when compared with pH 7.0. Furthermore, at pH 7.0, an aggregation process is observed with DTAB in the range from 0.75 to 1.5 mmol/L, noticed by the exothermic peak, and similar to that observed for pure oxy-HbGp, at pH 5.0, and in the presence of DTAB. DLS melting curves show a decrease on the hemoglobin thermal stability for the oxy-HbGp-DTAB mixtures and formation of larger aggregates, at pH 7.0. Our present data, together with previous results, support the observation that the protein structural changes, at pH 7.0, occur at smaller DTAB concentrations, as compared with pH 5.0, due to the acidic pI of protein that favors the oxy-HbGp-cationic surfactant interaction at neutral pH. PMID:26574155

  11. Calorimetric study of the effect of bent-shaped dopant molecules on the critical behavior at the nematic-smectic-Ad phase transition

    NASA Astrophysics Data System (ADS)

    Sasaki, Y.; Ema, K.; Le, K. V.; Takezoe, H.; Dhara, S.; Sadashiva, B. K.

    2011-06-01

    We report results of calorimetric studies for the binary mixture of rodlike host n-alkyloxy-cyanobiphenyl (nOCB, n=8,9) and bent-shaped guest 1,3-phenylene-bis[4-(3-methylbenzoyloxy)]-4'-n-dodecylbiphenyl-4'-carboxylate (BC12). The effect of bent-shaped dopant molecules on the critical behavior associated with the nematic-smectic-Ad phase transition has been studied in detail. The transition temperature for the nematic-smectic-Ad phase sharply decreases as the increase of the mole fraction of the dopant concentration (denoted X for the BC12/9OCB mixture and Y for the BC12/8OCB mixture). The dependence of the critical exponent α on X and Y is well explained in terms of the McMillan ratio. A nearly tricritical exponent has been obtained for the X=0.01 mixture. X=0.02-0.03 mixtures, pure 8OCB, and Y=0.01-0.03 mixtures exhibit nonuniversal behaviors with effective exponents lying between the 3D-XY and tricritical exponents. The heat capacity anomaly for Y=0.05 has been well described with the 3D-XY exponent. The critical amplitude ratio A-/A+ is close to 1 and insensitive to the dopant concentration. No Fisher renormalization of the critical exponent has been observed even for nearly tricritical compositions, which indicates the smallness of the concentration plays a decisive role rather than the steepness of the N-SmAd phase boundary.

  12. Calorimetric analysis of thermodynamic stability and aggregation for apo and holo amyotrophic lateral sclerosis-associated Gly-93 mutants of superoxide dismutase.

    PubMed

    Stathopulos, Peter B; Rumfeldt, Jessica A O; Karbassi, Farhad; Siddall, Clare A; Lepock, James R; Meiering, Elizabeth M

    2006-03-10

    Differential scanning calorimetry was used to measure changes in thermodynamic stability and aggregation for glycine 93 mutants of human copper, zinc-superoxide dismutase (SOD). Glycine 93 is a conserved residue at position i + 3 of a tight turn and has been found to be a mutational hot spot in familial amyotrophic lateral sclerosis (fALS). The fALS-associated mutations, G93A, G93S, G93R, G93D, and G93V, were made in a pseudo wild-type background containing no free cysteines, which prevented the formation of aberrant disulfide bonds upon thermal unfolding, and enabled quantitative thermodynamic analysis of the effects of the mutations. Thermal unfolding was highly reversible for all the SODs in both the fully metallated (holo) and metal-free (apo) forms. The data for all the holo-SODs and for the apo-pseudo-wild-type SOD were well fit by a 2-state unfolding model for native dimer (N2) to two unfolded monomers (2U), N2 <--> 2U. The holo- and apo-forms of the mutants are significantly destabilized (by 1.5-3.5 kcal mol(-1) monomer) relative to the corresponding forms of pseudo wild-type, with the relative stabilities being correlated with statistical preferences for amino acids in this structural context. Although van't Hoff (DeltaHvH) to calorimetric (DeltaHcal) enthalpy ratios are close to unity for all the holo-SODs and for apo-pseudo-wild-type, consistent with a 2-state transition, DeltaHvH is considerably larger than DeltaHcal for all the apo-mutants. This suggests that the mutations cause apo-SOD to have an increased propensity to misfold or aggregate, which may be linked to increased toxic mutant SOD aggregation in fALS. PMID:16407238

  13. Mise à jour sur le nouveau vaccin 9-valent pour la prévention du virus du papillome humain

    PubMed Central

    Yang, David Yi; Bracken, Keyna

    2016-01-01

    Résumé Objectif Informer les médecins de famille quant à l’efficacité, à l’innocuité, aux effets sur la santé publique et à la rentabilité du vaccin 9-valent contre le virus du papillome humain (VPH). Qualité des données Des articles pertinents publiés dans PubMed jusqu’en mai 2015 ont été examinés et analysés. La plupart des données citées sont de niveau I (essais randomisés et contrôlés et méta-analyses) ou de niveau II (études transversales, cas-témoins et épidémiologiques). Des rapports et recommandations du gouvernement sont aussi cités en référence. Message principal Le vaccin 9-valent contre le VPH, qui offre une protection contre les types 6, 11, 16, 18, 31, 33, 45, 52 et 58 du VPH, est sûr et efficace et réduira encore plus l’incidence des infections à VPH, de même que les cas de cancer lié au VPH. Il peut également protéger indirectement les personnes non immunisées par l’entremise du phénomène d’immunité collective. Un programme d’immunisation efficace peut prévenir la plupart des cancers du col de l’utérus. Les analyses montrent que la rentabilité du vaccin 9-valent chez les femmes est comparable à celle du vaccin quadrivalent original contre le VPH (qui protège contre les types 6, 11, 16 et 18 du VPH) en usage à l’heure actuelle. Toutefois, il faut investiguer plus en profondeur l’utilité d’immuniser les garçons avec le vaccin 9-valent contre le VPH. Conclusion en plus d’être sûr, le vaccin 9-valent protège mieux contre le VPH que le vaccin quadrivalent. Une analyse coûtefficacité en favorise l’emploi, du moins chez les adolescentes. Ainsi, les médecins devraient recommander le vaccin 9-valent à leurs patients plutôt que le vaccin quadrivalent contre le VPH.

  14. Le kyste hydatique du cordon spermatique: une localisation exceptionnelle

    PubMed Central

    Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

    2011-01-01

    L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique. PMID:22384304

  15. Modelisation du Signal Radar EN Milieu Stratifie et Evaluation de Techniques de Mesure de L'humidite du Sol

    NASA Astrophysics Data System (ADS)

    Boisvert, Johanne

    La presente etude se penche sur des problemes relies a l'echantillonnage de l'humidite de sol et a l'estimation du signal radar sur sols nus. Le travail se divise en deux volets. Le volet 1 evalue trois techniques de mesure de l'humidite du sol (gravimetrie, reflectometrie temporelle et sonde dielectrique) et deux protocoles d'echantillonnage. Dans le volet 2, un modele de simulation du signal en milieu stratifie est developpe, et les estimes de signal obtenus sont compares aux estimes bases uniquement sur une valeur moyenne d'humidite du sol prise sur une profondeur fixe d'echantillonnage. Les differences entre les deux estimes dependent de la frequence et du choix judicieux de la profondeur d'echantillonnage; elles sont plus importantes aux faibles angles et en polarisation HV, puis VV. Le modele de simulation a aussi ete utilise pour etudier la profondeur de penetration du signal et en deduire la profondeur optimale d'echantillonnage en tenant compte des caracteristiques du signal. Une variation de 25 ^circ de l'angle d'incidence a peu d'effet sur la profondeur de penetration en bande Ku; l'ecart reste inferieur ou egal a 0,5 cm en bande C mais peut atteindre 1,3 cm en bande L. L'impact de la polarisation est nul en bande Ku mais croi t avec l'angle d'incidence en bande C et L. A 50^circ, il est, en moyenne de 1 cm en bande C et de 2 cm en bande L. En polarisation VV, la profondeur croi t avec une augmentation de l'angle alors que l'effet est inverse en polarisation HH. Deux methodes pour estimer la profondeur d'echantillonnage en conditions operationnelles sont presentees. Lorsqu'on inverse un modele pour estimer l'humidite du sol a partir du signal, ces methodes permettent aussi d'estimer l'epaisseur de sol representee par l'humidite ainsi estimee.

  16. 78 FR 37652 - Environmental Impact Statement: Kenosha, Racine, Milwaukee, Waukesha, Washington, Dodge, Fond Du...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-21

    ..., Waukesha, Washington, Dodge, Fond Du Lac, Winnebago, Outagamie and Brown Counties, Wisconsin AGENCY... proposed Interstate conversion of U.S. Highway 41 in Milwaukee, Waukesha, Washington, Dodge, Fond du Lac... 41 to an Interstate in Milwaukee, Waukesha, Washington, Dodge, Fond du Lac, Winnebago, Outagamie,...

  17. La chirurgie du diaphragme sous aortique

    PubMed Central

    Moutakiallah, Younes; Maaroufi, Ilham; Aithoussa, Mahdi; Bamous, Mehdi; Abdou, Abdessamad; Atmani, Noureddine; Hatim, Abdedaïm; Amahzoune, Brahim; Bekkali, Youssef El; Boulahya, Abdelatif

    2016-01-01

    Le diaphragme sous aortique se caractérise par une certaine latence clinique et une faible morbi-mortalité. La chirurgie reste le traitement de choix malgré un réel risque de récurrence à long terme. Nous rapportons 18 patients opérés entre Avril 1994 et Mars 2011 pour diaphragme sous aortique d’âge moyen de 18,1±9,7 ans avec 11 patients de sexe masculin. Le diaphragme était de nature fibreuse chez 13 patients et fibro-musculaire chez 5 patients. Tous les patients ont été opérés par résection de diaphragme associée à une myectomie, une plastie aortique, une fermeture de communication interventriculaire et une ligature de canal artériel perméable respectivement chez 3, 3, 2 et 2 patients. La Mortalité opératoire était nulle et sans aucun cas de trouble de conduction postopératoire. Le suivi a duré en moyenne 44,3±36,8 mois sans aucun décès tardif. Deux patients ont présenté une récidive de diaphragme qui a nécessité une réopération avec bonne évolution. La tendance actuelle dans la chirurgie du diaphragme se fait vers des interventions précoces et des résections plus extensives. Cependant, le risque de récidive impose une surveillance échographique systématique et rapprochée. PMID:27516830

  18. Les rivières et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac

    USGS Publications Warehouse

    Taylor, George C., Jr.; Lemoine, Rémy C.

    1949-01-01

    Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

  19. Du pont ''Freon'' helps tap geothermal wells for power

    SciTech Connect

    Not Available

    1984-07-01

    Low-grade heat from geothermal wells can now be harnessed to produce electricity by using Du Pont ''Freon'' IF as the power conversion fluid. The new system was developed by Turbonetics Energy Inc. The company's Organic Rankine Cycle (ORC) system takes advantage of the low boiling point (117F) of Du Pont ''Freon'' TF. Geothermal energy is harnessed by utilizing the heat from 200F to 400F water to vaporize the ''Freon'' power fluid. Then the fluid expands through a turbine and drives a generator. The system can produce from 600 kW of electric power.

  20. Non-exponential nature of calorimetric and other relaxations: Effects of 2 nm-size solutes, loss of translational diffusion, isomer specificity, and sample size

    NASA Astrophysics Data System (ADS)

    Johari, G. P.; Khouri, J.

    2013-03-01

    Certain distributions of relaxation times can be described in terms of a non-exponential response parameter, β, of value between 0 and 1. Both β and the relaxation time, τ0, of a material depend upon the probe used for studying its dynamics and the value of β is qualitatively related to the non-Arrhenius variation of viscosity and τ0. A solute adds to the diversity of an intermolecular environment and is therefore expected to reduce β, i.e., to increase the distribution and to change τ0. We argue that the calorimetric value βcal determined from the specific heat [Cp = T(dS/dT)p] data is a more appropriate measure of the distribution of relaxation times arising from configurational fluctuations than β determined from other properties, and report a study of βcal of two sets of binary mixtures, each containing a different molecule of ˜2 nm size. We find that βcal changes monotonically with the composition, i.e., solute molecules modify the nano-scale composition and may increase or decrease τ0, but do not always decrease βcal. (Plots of βcal against the composition do not show a minimum.) We also analyze the data from the literature, and find that (i) βcal of an orientationally disordered crystal is less than that of its liquid, (ii) βcal varies with the isomer's nature, and chiral centers in a molecule decrease βcal, and (iii) βcal decreases when a sample's thickness is decreased to the nm-scale. After examining the difference between βcal and β determined from other properties we discuss the consequences of our findings for theories of non-exponential response, and suggest that studies of βcal may be more revealing of structure-freezing than studies of the non-Arrhenius behavior. On the basis of previous reports that β → 1 for dielectric relaxation of liquids of centiPoise viscosity observed at GHz frequencies, we argue that its molecular mechanism is the same as that of the Johari-Goldstein (JG) relaxation. Its spectrum becomes broader on

  1. Complete thermodynamic characterization of the multiple protonation equilibria of the aminoglycoside antibiotic paromomycin: a calorimetric and natural abundance 15N NMR study.

    PubMed

    Barbieri, Christopher M; Pilch, Daniel S

    2006-02-15

    The binding of aminoglycoside antibiotics to a broad range of macromolecular targets is coupled to protonation of one or more of the amino groups that typify this class of drugs. Determining how and to what extent this linkage influences the energetics of the aminoglycoside-macromolecule binding reaction requires a detailed understanding of the thermodynamics associated with the protonation equilibria of the aminoglycoside amino groups. In recognition of this need, a calorimetric- and NMR-based approach for obtaining the requisite thermodynamic information is presented using paromomycin as the model aminoglycoside. Temperature- and pH-dependent 15N NMR studies provide pK(a) values for the five paromomycin amino groups, as well as the temperature dependence of these pK(a) values. These studies also indicate that the observed pK(a) values associated with the free base form of paromomycin are lower in magnitude than the corresponding values associated with the sulfate salt form of the drug. This difference in pK(a) is due to drug interactions with the sulfate counterions at the high drug concentrations (> or = 812 mM) used in the 15N NMR studies. Isothermal titration calorimetry studies conducted at drug concentrations < or = 45 microM reveal that the extent of paromomycin protonation linked to the binding of the drug to its pharmacologically relevant target, the 16 S rRNA A-site, is consistent with the pK(a) values of the free base and not the sulfate salt form of the drug. Temperature- and pH-dependent isothermal titration calorimetry studies yield exothermic enthalpy changes (deltaH) for protonation of the five paromomycin amino groups, as well as positive heat capacity changes (deltaC(p)) for three of the five amino groups. Regarded as a whole, the results presented here represent an important first step toward establishing a thermodynamic database that can be used to predict how aminoglycoside-macromolecule binding energetics will be influenced by conditions such

  2. Baisse du HDL-cholestérol indicateur du stress oxydatif dans le diabète de type 2

    PubMed Central

    Kabamba, Arsène Tshikongo; Bakari, Salvius Amuri; Longanga, Albert Otshudi; Lukumwena, Zet Kalala

    2014-01-01

    L'hypercholestérolémie est étroitement liée au stress oxydatif. Lorsqu'il y a trop de cholestérol qui circule dans le sang, il n'est pas utilisé en totalité par les cellules et il risque de s'accumuler dans les vaisseaux sanguins. Cela peut entrainer la formation des plaques d'athérosclérose qui gênent la circulation sanguine et provoquent des accidents cardiovasculaires. Le stress oxydatif apparait très tôt dans l'histoire des complications du diabète de type 2, et est lié à l'oxydation du glucose mais aussi à la peroxydation lipidique. Le cholestérol-HDL est un marqueur important du stress oxydatif par sa capacité à faciliter la métabolisation du cholestérol, sa baisse est souvent considérée comme la source de beaucoup d'inquiétudes. L'objectif est l’évaluation de la variation du taux de cholestérol-HDL, marqueur du stress oxydatif, chez les patients diabétiques de type 2 dans la population congolaise. Nous avons inclus dans cette étude prospective des cas témoins des patients diabétiques de type 2 reconnus et diagnostiqués, et des témoins non diabétiques appariés selon l’âge et le sexe. Parallèlement au bilan biologique classique, une analyse d'un des facteurs de risque du stress oxydatif a été réalisée: baisse de HDL-Cholestérol. L’âge moyen des 30 patients diabétiques (47,77±10,78 ans) était comparable à celui des 30 témoins (48,83±10,73 ans). Une baisse significative du cholestérol-HDL dans le sang était observée chez 100% des diabétiques et 50% des témoins (p=0,0000). L'augmentation du HDL cholestérol permet d’éliminer le mauvais cholestérol en excès en nettoyant les tissus et en ramenant le cholestérol vers le foie. Lors du diabète de type 2 on constate une baisse sanguine sensible du taux de HDL-cholestérol, qui est signe indicateur du stress oxydatif. PMID:25767660

  3. Consequences experimentales des effets des fluctuations du vide sur la fluorescence parametrique et la generation du second harmonique en milieu confine

    NASA Astrophysics Data System (ADS)

    Robichaud, Luc

    Les fluctuations du vide, qui consistent en l'apparition momentanee de particules, ce qui est permit par le principe d'incertitude de Heisenberg, joue un role primordial dans les processus photoniques, en particulier les processus non-lineaires. Par la manipulation de ces fluctuations du vide a l'aide de confinement optique, on retrouve deux phenomenes particuliers : l'intensification de la fluorescence parametrique (Walker, 2008) et l'inhibition de la generation du second harmonique (Collette, 2013). Dans ce travail, on presente les resultats dans le cas classique ; c'est-a-dire sans fluctuations du vide et confinement. Par la suite, on presente les effets des fluctuations du vide et du confinement, ce qui mene aux deux effets mentionnes. Dans le cas de la fluorescence parametrique, le bruit quantique sur le champ interne et externe est calcule, le role du desaccord de phase dans le modele est expose et une generalisation tridimensionnelle est etudiee afin de generaliser la conception du modele d'un cas unidimensionnel a un cas tridimensionnel planaire. Dans le cas de la generation du second harmonique, les difficultes d'un modele purement tridimensionnel sont exposees et ensuite le cas limite planaire est etudie.

  4. Micro-machined calorimetric biosensors

    DOEpatents

    Doktycz, Mitchel J.; Britton, Jr., Charles L.; Smith, Stephen F.; Oden, Patrick I.; Bryan, William L.; Moore, James A.; Thundat, Thomas G.; Warmack, Robert J.

    2002-01-01

    A method and apparatus are provided for detecting and monitoring micro-volumetric enthalpic changes caused by molecular reactions. Micro-machining techniques are used to create very small thermally isolated masses incorporating temperature-sensitive circuitry. The thermally isolated masses are provided with a molecular layer or coating, and the temperature-sensitive circuitry provides an indication when the molecules of the coating are involved in an enthalpic reaction. The thermally isolated masses may be provided singly or in arrays and, in the latter case, the molecular coatings may differ to provide qualitative and/or quantitative assays of a substance.

  5. College of DuPage Student Portrait, Fall Quarter 1999.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

    The report profiles the College of DuPage's (COD) fall quarter 1999 student body. It presents a brief history of the college's enrollment and a comparison of enrollments with other Illinois community colleges. It also provides demographic information on current students. Additionally, enrollment information is included by program, division, and…

  6. W. E. B. Du Bois: Reform, Will, and the Veil

    ERIC Educational Resources Information Center

    England, Lynn; Warner, W. Keith

    2013-01-01

    While W. E. B. Du Bois is widely recognized for his contributions to the sociology of race, his contributions to the foundations of sociology are largely ignored. His sociology is based on African American reformism, a version of pragmatism, and a contingent historicism. The basic view of sociology is one that emphasizes the role of chance and…

  7. Pic-du-Midi Observatory (Observatoire Midi-Pyrenees) (OMP)

    NASA Astrophysics Data System (ADS)

    Murdin, P.

    2000-11-01

    OMP is under the administrative supervision of both the Institute des Sciences de l'Univers (INSU) of the French National Center for Scientific Research (CNRS) and the Ministry of Research, Technology and Education. It has laboratories located at the Université Paul Sabatier in Toulouse, Bagnères, Lannemezan and at the summit of Pic du Midi de Bigorre....

  8. Cost-Effective Remediation of Depleted Uranium (DU) at Environmental Restoration Sites

    SciTech Connect

    MILLER,MARK; GALLOWAY,ROBERT B.; VANDERPOEL,GLENN; JOHNSON,ED; COPLAND,JOHN; SALAZAR,MICHAEL

    1999-11-03

    Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon-development programs, at firing practice ranges, or in war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discrete, visually identifiable DU fragments mixed with native soil. The bulk-averaged DU activity is quite low, whereas DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is quite visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that DU is radioactive and visually identifiable makes it desirable to remove the DU ''contamination'' from the environment. The typical approach to conducting this DU remediation is to use radiation-detection instruments to identify the contaminant and then to separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

  9. Paralysie néonatal unilatérale du nerf radial

    PubMed Central

    Benemmane, Halima; Hali, Fouzia; Marnissi, Farida; Benchikhi, Hakima

    2015-01-01

    La paralysie néonatale unilatérale du nerf radial est rare, son diagnostic est essentiellement clinique, elle peut-être diagnostiquée à tort en tant que paralysie du plexus brachial. Nous rapportons un cas clinique. A l'examen clinique du nouveau-né; l'extension du poignet, du pouce et des articulations métacarpo-phalangiennes était impossible, alors qu'il y avait une conservation de la prono-supination et la flexion du poignet et des mouvements de l’épaule et du coude. Le diagnostic de la paralysie du plexus brachial était écarté cliniquement devant la mobilisation active de l’épaule et la flexion du coude. Notre patient a bénéficié de kinésithérapie pour éviter l'apparition d'attitudes vicieuses et d'amyotrophie. L'extension active du poignet était obtenue après deux mois. PMID:26587133

  10. Les inconvénients de perdre du poids

    PubMed Central

    Bosomworth, N. John

    2012-01-01

    Résumé Objectif Explorer les raisons pour lesquelles la perte de poids à long terme échoue la plupart du temps et évaluer les conséquences de diverses trajectoires pondérales, y compris la stabilité, la perte et le gain. Source des données Les études qui évaluent les paramètres pondéraux dans la population sont en majorité observationnelles. Des données probantes de niveau I ont été publiées pour évaluer l’influence des interventions relatives au poids sur la mortalité et la qualité de vie. Message principal Seulement un petit pourcentage des personnes qui désirent perdre du poids réussissent à le faire de manière durable. La mortalité est la plus faible chez les personnes se situant dans la catégorie de poids élevé-normal et surpoids. La trajectoire pondérale la plus sécuritaire est la stabilité du poids avec une optimisation de la condition physique et métabolique. Il est démontré que la mortalité est plus faible chez les personnes ayant des comorbidités reliées à l’obésité si elles perdent du poids. Il est aussi établi que la qualité de vie sur le plan de la santé est meilleure chez les personnes obèses qui perdent du poids. Par contre, la perte de poids chez une personne obèse autrement en santé est associée à une mortalité accrue. Conclusion La perte de poids est recommandable seulement chez les personnes qui ont des comorbidités reliées à l’obésité. Les personnes obèses en santé qui veulent perdre du poids devraient être informées qu’il peut y avoir des risques à le faire. Une stratégie qui se traduit par un indice de masse corporelle stable avec une condition physique et métabolique optimisée, peu importe le poids, est l’option d’intervention la plus sécuritaire en ce qui concerne le poids.

  11. Rupture simultanée du ligament croisé antérieur et du ligament patellaire: à propos d'un cas

    PubMed Central

    Achkoun, Abdessalam; Houjairi, Khalid; Quahtan, Omar; Hassoun, Jalal; Arssi, Mohamed; Rahmi, Mohamed; Garch, Abdelhak

    2016-01-01

    La rupture simultanée du tendon rotulien et du ligament croisé antérieur est une lésion relativement rare. Son diagnostic peut facilement manquer lors de l'examen initial. Les options de traitement incluent la réparation immédiate du tendon rotulien avec soit la reconstruction simultanée ou différée de ligament croisé antérieur. Nous rapportons le cas d'une rupture combinée du tendon rotulien et du ligament croisé antérieur chez un jeune footballeur de 22 ans. Une approche de traitement en deux temps a été effectuée avec un excellent résultat fonctionnel. PMID:27366288

  12. A Conversation with Lee Alvin DuBridge - Part I

    NASA Astrophysics Data System (ADS)

    Goodstein, Judith R.

    Physicist Lee A. DuBridge became president of the California Institute of Technology in 1946. In this interview he recalls the immediate problems he faced, including his dealings with Robert A. Millikan, whom he replaced as chief administrator of the institute; institute financing and inadequate salaries. DuBridge also talks about the advent of federal support for peacetime science and Millikan's distaste for it; his close working relationship with Robert F. Bacher, who came to the institute in 1949 as chairman of the Division of Physics, Mathematics, and Astronomy; his recollections of the meteorologist Irving P. Krick, the physicist Alexander Goetz, and the chemist Linus Pauling; and his attempts to build up the Humanities Division.

  13. Du Pont Classifications of 2 ASAS-SN Supernovae

    NASA Astrophysics Data System (ADS)

    Shappee, Benjamin J.; Prieto, J. L.; Rich, J.; Madore, B.; Poetrodjojo, Henry; D'Agostino, Joshua

    2016-09-01

    We report optical spectroscopy (range 370-910 nm) of two supernovae discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN; Shappee et al. 2014, ApJ, 788, 48) using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory on Aug. 30 and Sep. 1 2016 UT. We performed a cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, Ap.J.

  14. Du Pont Classifications of 4 ASAS-SN Supernovae

    NASA Astrophysics Data System (ADS)

    Morrell, N.; Shappee, Benjamin J.

    2016-08-01

    We report optical spectroscopy (range 370-910 nm) of four supernovae discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN; Shappee et al. 2014, ApJ, 788, 48) using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory on July 31 and Aug. 01 2016 UT. We performed a cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, Ap.J.

  15. Une forme exceptionnelle de la luxation perilunaire du carpe

    PubMed Central

    Elouakili, Issam; Ouchrif, Younes; Najib, Abdeljaouad; Ouakrim, Redouane; Lamrani, Omar; Kharmaz, Mohammed; Ismael, Farid; Lahlou, Abdo; Elouadghiri, Mohammed; El Bardouni, Ahmed; Mahfoud, Mustapha; Berrada, Mohammed Saleh; El Yaccoubi, Mouradh

    2014-01-01

    Les luxations périlunaires (LPL) du carpe sont des lésions extrêmement rares, qui peuvent passer inaperçue en raison d'un tableau clinique souvent trompeur, des radiographies en profil non strict ou d'interprétation difficile. Nous rapportons l'observation d'une luxation périlunaire stade III selon la classification de Witvoët et Allieu chez un patient de 32 ans, il s'agit d'une forme encore plus rare voire exceptionnelle et qui peut induire de sérieux problèmes en raison de la sévérité des dommages ligamentaires et du risque de nécrose du semilunaire plus important dans ce type de lésions. Le traitement est toujours chirurgical et doit être réalisé dans les plus brefs délais afin d’éviter les complications. PMID:25404968

  16. Low-temperature heat capacity of diopside glass (CaMgSi2O6): A calorimetric test of the configurational-entropy theory applied to the viscosity of liquid silicates

    USGS Publications Warehouse

    Richet, P.; Robie, R.A.; Hemingway, B.S.

    1986-01-01

    Heat-capacity measurements have been made between 8 and 370 K on an annealed and a rapidly quenched diopside glass. Between 15 and 200 K, Cp does not depend significantly on the thermal history of the glass. Below 15 K Cp is larger for the quenched than for the annealed specimen. The opposite is true above 200 K as a result of what is interpreted as a secondary relaxation around room temperature. The magnitude of these effects, however, is small enough that the relative entropies S(298)-S(0) of the glasses differ by only 0.5 J/mol K, i.e., a figure within the combined experimental uncertainties. The insensitivity of relative entropies to thermal history supports the assumption that the configurational heat capacity of the liquid may be taken as the heat capacity difference between the liquid and the glass (??Cp). Furthermore, this insensitivity allows calculation of the residual entropies at 0 K of diopside glasses as a function of the fictive temperature from the entropy of fusion of diopside and the heat capacities of the crystalline, glassy and liquid phases. For a glass with a fictive temperature of 1005 K, for example, this calorimetric residual entropy is 24.3 ?? 3 J/mol K, in agreement with the prediction made by RICHET (1984) from an analysis of the viscosity data with the configurational-entropy theory of relaxation processes of Adam and Gibbs (1965). In turn, all the viscosity measurements for liquid diopside, which span the range 0.5-4?? 1013 poise, can be quantitatively reproduced through this theory with the calorimetrically determined entropies and ??Cp data. Finally, the unclear significance of "activation energies" for structural interpretations of viscosity data is emphasized, and the importance of ??Cp and glass-transition temperature systematics for determining the composition and temperature dependences of the viscosity is pointed out. ?? 1986.

  17. Annuaire du bureau des Longitudes : guide de données astronomiques 2011 pour l'observation du ciel

    NASA Astrophysics Data System (ADS)

    Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

    2010-07-01

    Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

  18. Annuaire du bureau des Longitudes : guide de données astronomiques 2012 pour l'observation du ciel

    NASA Astrophysics Data System (ADS)

    Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

    2011-07-01

    Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

  19. Association between Fatigue and Autistic Symptoms in Children with Cri du Chat Syndrome

    ERIC Educational Resources Information Center

    Claro, Anthony; Cornish, Kim; Gruber, Reut

    2011-01-01

    In the current study, the authors examined whether the fatigue level of children diagnosed with cri du chat syndrome was associated with the expression of autistic symptoms. Sixty-nine children with cri du chat syndrome were compared with 47 children with moderate to severe intellectual disabilities who did not differ on intellectual severity.…

  20. Luxation de l’épaule compliquée de paralysie du plexus brachial

    PubMed Central

    Lukulunga, Loubet Unyendje; Moussa, Abdou Kadri; Mahfoud, Mustapha; EL Bardouni, Ahmed; Berrada, Mohamed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Les auteurs rapportent l'observation d'une paralysie totale du plexus brachial survenue trois mois après un épisode de luxation antéro-interne sous coracoïdienne associée à une fracture du trochiter chez une patiente âgée de 88 ans. PMID:25426187

  1. Non-destructive analysis of DU content in the NIF hohlraums

    SciTech Connect

    Gharibyan, Narek; Moody, Ken J.; Shaughnessy, Dawn A.

    2015-12-16

    The advantage of using depleted uranium (DU) hohlraums in high-yield deuterium-tritium (DT) shots at the National Ignition Facility (NIF) is addressed by Döppner, et al., in great detail [1]. This DU based hohlraum incorporates a thin layer of DU, ~7 μm thick, on the inner surface along with a thin layer of a gold coating, ~0.7 μm thick, while the outer layer is ~22 μm thick gold. A thickness measurement of the DU layer can be performed using an optical microscope where the total DU weight can be computed provided a uniform DU layer. However, the uniformity of the thickness is not constant throughout the hohlraum since CAD drawing calculations of the DU weight do not agree with the computed values from optical measurements [2]. Therefore, a non-destructive method for quantifying the DU content in hohlraums has been established by utilizing gamma-ray spectroscopy. The details of this method, along with results from several hohlraums, are presented in this report.

  2. Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage

    PubMed Central

    Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

    2011-01-01

    Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures. PMID:22262963

  3. Prevalence of Autism Spectrum Phenomenology in Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna F.; Oliver, Chris; Berg, Katy; Kaur, Gurmeash; Jephcott, Lesley; Cornish, Kim

    2008-01-01

    Autism spectrum disorder characteristics have not been evaluated in Cornelia de Lange and Cri du Chat syndromes using robust assessments. The Autism Diagnostic Observation Schedule and Social Communication Questionnaire were administered to 34 participants with Cornelia de Lange syndrome and a comparison group of 23 participants with Cri du Chat…

  4. Dysfonctionnements radio-induits du transport colique chez le rat

    NASA Astrophysics Data System (ADS)

    François, A.; Lebrun, F.; Ksas, B.; Aigueperse, J.; Gourmelon, P.; MacNaughton, W. K.; Griffiths, N. M.

    1998-04-01

    The symptom commonly associated with whole body irradiation is diarrhoea, a still quite obscure phenomenon, which leads to decreased chance of cure of irradiated people. The aim of this study was to provide evidence for dysfunction of intestinal water and electrolyte transport regulation by the enteric nervous system after exposure to ionising radiation. This study shows decreased capacity of enteric nervous system to influence colonic transport 3days after irradiation, correlated to a diminished response to a neurotransmitter: serotonin. Radio-induced diarrhea may result from epithelial structural injury but also from impaired regulatory processes of intestinal transport. L'un des symptômes majeurs d'une irradiation corporelle totale ou abdominale est l'apparition de diarrhées, dont les causes sont encore mal connues, et qui mettent en jeu le pronostique vital de l'individu irradié. Cette étude vise à mettre en évidence l'atteinte de la régulation du transport intestinal d'eau et d'électrolytes par les rayonnements ionisants. On observe une diminution de la capacité du système nerveux entérique à influencer le transport colique 3jours après irradiation, corrélée à une diminution de la réponse épithéliale à un neurotransmetteur : la sérotonine. Les diarrhées radio-induites résulteraient d'une atteinte structurelle de l'épithélium mais également des processus de régulation du transport intestinal.

  5. Automation of Pic du Midi 2-m Telescope Bernard Lyot

    NASA Astrophysics Data System (ADS)

    Lavie-Cambot, Jean-Marie; Lacassagne, F.; Ambert, P.; Arrotis, J.-M.; Argentin, Y.; Arberet, M.-P.; Chereau, E.; Decha, C.; Delaigue, C.; Guesdon, L.; Laurent-Burguiere, D.; Malbreil, G.

    2011-03-01

    Since 2007, Pic du Midi 2-m Telescope Bernard Lyot is dedicated to spectropolarimetry with a scientific niche in stella magnetism. In parallel, TBL is progressively evolving from an analogic human-controlled telescope, to a fully automated computer controlled digital telescope. This evolution required TBL team to replace all electronics and motors with digital system (parvex, brushless motors, buscan) components, and to integrate the dataflow system from proposal to archiving into a fully coordinates, remote-access software suite. A trained technician can already control remotely the telescope, instrument and science programs from anywhere. Further robotisation will require a high-level expert system to be defined.

  6. Portage vaginal du streptocoque du groupe B chez la femme enceinte au niveau de la région de Marrakech

    PubMed Central

    Bassir, Ahlam; Dhibou, Hanane; Farah, Majdi; Mohamed, Lharmis; Amal, Addebous; Nabila, Souraa; Abderahim, Aboulfalah; Asmouki, Hamid; Soummani, Abderraouf

    2016-01-01

    Introduction Le streptocoque du groupe B est le principal agent impliqué dans les infections materno-fœtales, les septicémies et les méningites du nouveau-né à terme. L'objectif est de déterminer le taux de portage maternel du streptocoque du groupe B (SGB) à terme. Méthodes Un prélèvement vaginal a été réalisé de manière prospective chez 275 parturientes lors de l'entrée en salle d'accouchement sur une période de 06 mois. Résultats Le taux de portage était de 20,2%. Le portage était variable en fonction de l’âge gestationnel, il constitue 57.5% entre 37 et 38 semaines d'aménorrhée. Aucun des facteurs de risque n'a était statistiquement prédictif du portage maternel du SGB. Conclusion Le dépistage doit être réalisé à partir de 37 semaines d'aménorrhée, et comme le portage est intermittent, un prélèvement négatif ne garantirait pas que le portage soit négatif à l'accouchement. PMID:27222693

  7. Les astronomes de l'Empire du Milieu

    NASA Astrophysics Data System (ADS)

    Bonnet-Bidaud, J. M.

    2007-02-01

    Explosions d'étoiles, comètes, durée du jour, taches solaires, dans tous ces domaines, des observations chinoises datant de plusieurs siècles sont encore utilisées aujourd'hui. Pendant plus de 4000 ans, les astronomes de l'Empire du Milieu, organisés dans les grands observatoires impériaux, ont noté jour après jour, mois après mois, avec la plus grande précision tous les phénomènes célestes. Et ce sont des milliers de textes couvrant des périodes depuis au moins le Ve siècle avant l'ère moderne jusqu'à fin de la dernière dynastie des Qing en 1911, qui ont été conservés et dont une grande partie n'a pu encore être véritablement étudiée. Un véritable trésor, malheureusement très mal connu en Europe et, de façon incompréhensible, largement ignoré par l'histoire moderne des sciences.

  8. A systematic review of the oral and craniofacial manifestations of cri du chat syndrome.

    PubMed

    Corcuera-Flores, José-Ramón; Casttellanos-Cosano, Lizett; Torres-Lagares, Daniel; Serrera-Figallo, María Ángeles; Rodríguez-Caballero, Ángela; Machuca-Portillo, Guillermo

    2016-07-01

    Cri du chat syndrome is an autosomal disorder. Because it affects few people in the population it is considered a rare disease, yet it is one of the most common autosomal chromosomal syndromes in humans. It entails pathognomonic alterations that affect the craniofacial and oral anatomy of patients. The aim of this study is to review these craniofacial and oral abnormalities in patients with Cri du chat syndrome. The PubMed Medline database was searched using two different strategies. First, we used "Dentistry" and "Cri du chat" as keywords; second, we used "Cri du chat" and "craniofacial." Seven articles in which the main orofacial and cranio-skeletal characteristics of patients with Cri du chat syndrome were described were selected according to the inclusion and exclusion criteria. Cri du Chat syndrome entails pathognomonic characteristics in the craniofacial area (epicanthus, short philtrum, and wide nasal bridge), the oral area (mandibular retrognathism and anterior open bite) and the cranial region (alterations at the cranial base angle and a small upper airway). However, more studies on larger samples are needed to specify the orofacial and craniofacial characteristics of patients with Cri du chat syndrome more accurately. Clin. Anat. 29:555-560, 2016. © 2015 Wiley Periodicals, Inc. PMID:26457586

  9. Carcinome colloïde du sein: à propos d'un cas

    PubMed Central

    Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

    2013-01-01

    Nous rapportons le cas d'une tumeur colloïde du sein chez un homme. Cette situation rare interpelle par son mode de découverte. Nous avons pris en charge un homme de 60 ans atteint d'une lésion rétro-aréolaire droite classée cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu à un carcinome colloïde muqueux associé à une petite composante canalaire classique de grade I de SBR du sein. Les traitements complémentaires associent mastectomie, curage, chimiothérapie, radiothérapie et hormonothérapie. Le cancer du sein est rare chez l'homme. Le carcinome colloïde est exceptionnel puisqu'il représente seulement 1 à 6% de l'ensemble des cancers du sein. Il est encore plus rare chez l'homme. Ces tumeurs touchent une population spécifique et ont un meilleur pronostic que les autres types prépondérant dans les cancers du sein chez l'homme. A travers cette observation et une revue de la littérature, nous essaierons de discuter les principales caractéristiques anatomo-cliniques et évolutives de cette forme rare du cancer du sein. PMID:24772222

  10. Anévrysme ventriculaire gauche et communication interventriculaire compliquant un infarctus du myocarde

    PubMed Central

    Belkhadir, Mohammed; MoutakiAllah, Younes; Raissouni, Zainab; Abdou, Abdessamad; Bamous, Mehdi; Nya, Fouad; Atmani, Noureddine; Houssa, Mahdi Ait; El Bekkali, Youssef; Boulahya, Abdellatif

    2014-01-01

    L'association d'une communication interventriculaire post infarctus du myocarde et d'un anévrysme du ventricule gauche chez un même patient est extrêmement rare et survient habituellement durant la première semaine qui suit un infarctus du myocarde. Nous rapportons le cas insolite d'un patient âgé de 63 ans, admis pour choc cardiogénique en rapport avec une communication inter ventriculaire apicale et un anévrysme ventriculaire gauche causés par un infarctus du myocarde antérieur. La correction chirurgicale a consisté en une fermeture du défect septal par un patch en dacron via une ventriculotomie gauche associée à une anévrysectomie et un mono pontage coronaire. Cette observation illustre d'une part la rareté de l'association communication inter ventriculaire-anévrysme ventriculaire gauche post infarctus du myocarde, et d'autre part l'efficacité du traitement chirurgical qui reste la seule option salvatrice pour cette pathologie. PMID:25328617

  11. Le syndrome de Cri du Chat : A propos d’une observation

    PubMed Central

    Ouldim, Karim; Samri, Imane; Bouguenouch, Laila; Hamdaoui, Hasna; Otmani, Ihsan El; Hbibi, Mohamed; Chaouki, Sana; Hida, Moustapha

    2012-01-01

    Le syndrome du Cri du Chat (Cri du Chat syndrome, CdCS) est une anomalie chromosomique résultant d’une délétion de taille variable de l’extrémité du bras court du chromosome 5 (5p), incluant une région critique située en p15.2. Il représente une des délétions chromosomiques les plus fréquentes, son incidence dans la population générale est de 1/20 000 à 1/50 000. Les caractéristiques cliniques comprennent un cri monochromatique aigu, une microcéphalie, une dysmorphie cranio-faciale caractéristique évoluant avec l’âge et un retard mental et psychomoteur important. La taille de la délétion est variable, Le traitement est fonction des différents symptômes. Un remaniement chromosomique parental est retrouvé dans 12% des cas et la majorité des délétions responsables de la maladie du cri-du-chat surviennent de novo. Nous présentons une observation d’un syndrome du Cri du Chat, confirmé par caryotype métaphasique (46,XY,del(5)(p13) de novo). A travers cette observation nous mettrons à jour, les actualités scientifiques de ce rare syndrome, ainsi que la place des explorations cytogénétiques dans le diagnostic précis et le conseil génétique des syndromes dysmorphiques. PMID:22368747

  12. Le traumatisme du colon: l'expérience du CHU Hassan II de Fès

    PubMed Central

    Benjelloun, El Bachir; Hafid, Hasnai; Karim, Ibnmajdoub; Ousadden, Abdelmalek; Mazaz, Khalid; Taleb, Kahlid Ait

    2012-01-01

    Introduction Les traumatismes du colon sont associés à un risque majeur de complications septiques et de mortalité. Le but de notre étude est d’évaluer les circonstances, la prise en charge, le suivi et les facteurs pronostic de morbidité postopératoire des malades victimes d'un traumatisme colique. Méthodes Il s'agit d'une étude rétrospective sur une série de 49 patients opérés pour des plaies coliques aux services de chirurgie viscérale du CHU HASSAN II de Fès sur une période de 8 ans de juillet 2003 à juillet 2011. Résultats L’âge moyen de nos patients était de 25ans (16-70) avec une nette prédominance masculine (93.8%). Les plaies coliques secondaires à un traumatisme par arme blanche représentent 85% des cas (42 patients), suivi par les plaies iatrogènes au cours d'une coloscopie chez 6 patients (13%), puis les contusions abdominales chez 1 patient (2%). Les parties du cadre colique les plus touchées étaient le colon transverse chez 19 patients (38%) et le colon descendant chez 12 patients (24, 5%). Le colon sigmoïde était le segment le plus touché au cours d'une coloscopie4/6. Quarante-deux patients (85%) ont eu une suture primaire des plaies coliques, six patients (13%) une diversion fécale et un patient (2%) une résection-anastomose. Deux patients (4%) sont décédés suite à un choc septique. La morbidité globale était de 38,7% dominé essentiellement par l'infection de la paroi chez 14 patients et une péritonite post opératoire chez 3 patients. L'analyse univarié a montré une différence significatif en terme d'infection de la paroi entre le groupe colostomie versus suture simple (50% vs 20,9% p<0,05). L'atteinte du colon gauche et la réalisation d'une colostomie sont associés à un risque plus élevés de complications postopératoires. Conclusion La suture primaire peut être effectuée avec un faible taux de complications postopératoire chez la majorité des patients suite à un traumatisme du colon. PMID

  13. Solution NMR and calorimetric analysis of Rem2 binding to the Ca2+ channel β4 subunit: a low affinity interaction is required for inhibition of Cav2.1 Ca2+ currents.

    PubMed

    Xu, Xingfu; Zhang, Fangxiong; Zamponi, Gerald W; Horne, William A

    2015-05-01

    Rem, Rad, Kir/Gem (RGK) proteins, including Rem2, mediate profound inhibition of high-voltage activated Ca(2+) channels containing intracellular regulatory β subunits. All RGK proteins bind to voltage-gated Ca(2+) channel β subunit (Cavβ) subunits in vitro, but the necessity of the interaction for current inhibition remains controversial. This study applies NMR and calorimetric techniques to map the binding site for Rem2 on human Cavβ4a and measure its binding affinity. Our experiments revealed 2 binding surfaces on the β4 guanylate kinase domain contributing to a 156 ± 18 µM Kd interaction: a hydrophobic pocket lined by 4 critical residues (L173, N261, H262, and V303), mutation of any of which completely disrupted binding, and a nearby surface containing 3 residues (D206, L209, and D258) that when individually mutated decreased affinity. Voltage-gated Ca(2+) channel α1A subunit (Cav2.1) Ca(2+) currents were completely inhibited by Rem2 when co-expressed with wild-type Cavβ4a, but were unaffected by Rem2 when coexpressed with a Cavβ4a site 1 (L173A/V303A) or site 2 (D258A) mutant. These results provide direct evidence for a low-affinity Rem2/Cavβ4 interaction and show definitively that the interaction is required for Cav2.1 inhibition. PMID:25563298

  14. Localisation inhabituelle de la tuberculose: ostéoarthrite tuberculose du pouce

    PubMed Central

    Mortaji, Aziz; Koulali, Khalid; Galuia, Farid

    2014-01-01

    L'ostéoarthrite tuberculose est rare au niveau des doigts. Nous rapportons une observation d'atteinte du pouce chez un patient de 55 ans. Il avait présenté une tuméfaction douloureuse du pouce droit suite à un traumatisme du pouce. L’étude bactériologique et une biopsie avaient permis de confirmer le diagnostic. Un traitement antibacillaire de 12 mois avait donné des résultats satisfaisants. Les particularités de la prise en charge sont discutées par rapport aux données de la littérature. PMID:25932075

  15. DuPont/HFM Forum on carpet in health care facilities. Third in a series.

    PubMed

    1994-01-01

    DuPont and Health Facilities Management magazine invited 20 national experts to Dalton, GA--the carpet-manufacturing capital of the world--last year to take part in DuPont's first-ever Forum on Carpet in Health Care Facilities. During the two-hour roundtable discussion, moderated by DuPont's C. Jack Murph and HFM's Michael Hemmes, end-users, interior designers and carpet mill representative talked about the aesthetic, economic and performance aspects of using carpet in health care settings. Here's an edited version of what they said. PMID:10184014

  16. DuPont/HFM Forum on carpet in health care facilities. Roundtable discussion.

    PubMed

    Murph, J; Hemmes, M; Blyth, P L; Plappert, K K; Noell, E; VanStavern, V; Cama, R; Lynn, V; Pollitt, B S; Rainey, P M

    1993-11-01

    DuPont and Health Facilities Management magazine invited 20 national experts to Dalton, GA--the carpet-manufacturing capital of the world--on May 13 to take part in DuPont's first-ever Forum on Carpet in Health Care Facilities. During the two-hour roundtable discussion, moderated by DuPont's C. Jack Murph and HFM's Michael Hemmes, end-users, interior designers and mill representatives talked about the aesthetic, economic and performance aspects of using carpet in health care settings. Here's an edited version of what they said. PMID:10183973

  17. Etude theorique du jet de plasma supersonique a courant continu

    NASA Astrophysics Data System (ADS)

    Jodoin, Bertrand

    La déposition par plasma supersonique à courant continu permet d'obtenir une qualité de dépôt supérieure au jet subsonique. Un modèle numérique a été développé dans le but de mieux comprendre les mécanismes de transfert à l'intérieur de la tuyère et d'estimer l'influence des paramètres d'opération de la torche sur le jet à la sortie de la tuyère. Les équations d'Euler, auxquelles sont ajoutées l'effet Joule, la conduction et les pertes par rayonnement sont résolues à l'aide de la méthode de Jameson. Un schéma centré est utilisé pour résoudre les champs électriques. La sous-couche cathodique en déséquilibre thermodynamique est modélisée à l'aide du modèle simple de Morrow et Lowke. Quelques détails sur les aspects numériques facilitant la convergence du système sont donnés. Le modèle est validé pour un écoulement compressible classique et pour un jet de plasma supersonique à l'aide de résultats de la littérature. Les champs à l'intérieur de la tuyère sont analysés afin de déterminer l'influence de l'hydrogène, de l'intensité du courant et de la géométrie de la tuyère sur les caractéristiques de l'écoulement.

  18. Polymorphisme de l'apolipoprotéine E dans la population du nord du Maroc: fréquence et influence sur les paramètres lipidiques

    PubMed Central

    Benyahya, Fatiha; Barakat, Amina; Ghailani, Naima; Bennani, Mohcine

    2013-01-01

    Introduction L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH. PMID:24396563

  19. Cirque du Monde en tant qu’intervention en santé

    PubMed Central

    Fournier, Cynthia; Drouin, Mélodie-Anne; Marcoux, Jérémie; Garel, Patricia; Bochud, Emmanuel; Théberge, Julie; Aubertin, Patrice; Favreau, Gil; Fleet, Richard

    2014-01-01

    Résumé Objectif Présenter le programme Cirque du Monde du Cirque du Soleil et son potentiel en tant qu’intervention en soins de santé de première ligne pour les médecins de famille. Sources des données Une revue de la littérature menée dans les bases de données PubMed, Cochrane Library, PsycINFO, La Presse, Eureka, Google Scholar et Érudit à l’aide des mots-clés circus, social circus, Cirque du Monde et Cirque du Soleil. Une initiative à Montréal nommée Espace Transition qui s’inspire directement de Cirque du Monde. Communication personnelle avec le conseiller principal en formation en cirque social du Cirque du Soleil. Sélection d’études Les 50 premiers articles ou sites Internet répertoriés pour chaque mot-clé dans chacune des bases de données ciblées ont été révisés sur la base des titres et des résumés, s’il s’agissait d’un article, ou sur la base du titre et du contenu de la page, s’il s’agissait d’une page Internet. Ensuite, les articles et les sites Internet qui étudiaient un aspect du cirque social ou qui présentaient une intervention impliquant le cirque étaient retenus pour une révision. Aucune contrainte d’année de publication n’a été appliquée étant donné qu’on cherchait une littérature générale sur le cirque social. Synthèse Aucun article n’a été trouvé sur le cirque social en tant qu’intervention en santé. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention en milieu scolaire. Cette étude a démontré une augmentation de l’estime personnelle des enfants grâce à l’intervention. Nous avons trouvé une étude sur l’utilisation du cirque en tant qu’intervention sur une réserve amérindienne. Cette étude présente des résultats qualitatifs non spécifiques au programme du cirque social. Les autres articles répertoriés n’étaient que des descriptions du cirque social. Un site web concernant l’utilisation du cirque social pour

  20. Proprietes ionochromes et photochromes de derives du polythiophene

    NASA Astrophysics Data System (ADS)

    Levesque, Isabelle

    La synthese et la caracterisation de derives regioreguliers du polythiophene ont ete effectuees en solution et sur des films minces. La spectroscopie UV-visible de ces derives a permis de constater qu'ils peuvent posseder des proprietes chromiques particulieres selon le stimulus auquel ils sont soumis. Par exemple, une augmentation de la temperature permet en effet aux polymeres de passer d'une couleur violette a jaune, et ce, a l'etat solide aussi bien qu'en solution. Ces proprietes chromiques semblent regies par une transition conformationnelle (plane a non-plane) de la chaine principale. Ce travail avait pour but de mieux comprendre l'influence de l'organisation des chaines laterales sur les transitions chromiques. Deux derives synthetises possedant des chaines laterales sensibles aux cations alcalins se sont averes etre ionochromes en plus d'etre thermochromes. Il s'agit d'un polymere comportant des chaines laterales de type oligo(oxyethylene) et d'un autre comportant un groupement ether couronne specifique aux ions lithium. Les effets chromiques observes sont expliques par des interactions non-covalentes des cations avec les atomes d'oxygene des chaines laterales dans le cas du premier polymere, et par l'insertion de l'ion Li + dans la cavite de l'ether couronne dans le cas du second polymere. Ces interactions semblent provoquer une diminution de l'organisation induisant ainsi une torsion de la chaine principale. Les deux polymeres semblent specifiques a certains cations et pourraient donc servir comme detecteurs optiques. La specificite aux ions Li+ du second polymere pourrait aussi permettre la conduction ionique, en plus de la conductivite electronique caracteristique des polythiophenes, ce qui pourrait s'averer utile dans le cas de batteries legeres entierement faites de polymeres et de sels de lithium. D'autres derives comportant des chaines laterales de type azobenzene se sont averes etre photochromes en plus d'etre thermochromes. Le groupement lateral a

  1. Restauration fonctionnelle du rachis : effet du niveau initial de douleur sur les performances des sujets lombalgiques chroniques

    PubMed Central

    Caby, Isabelle; Olivier, N; Mendelek, F; Kheir, R Bou; Vanvelcenaher, J; Pelayo, P

    2014-01-01

    HISTORIQUE : La lombalgie chronique est une douleur lombaire persistante d’origine multifactorielle. Le niveau de douleur initial reste faiblement utilisé pour analyser et comparer les réponses des patients lombalgiques au programme de reconditionnement. OBJECTIFS : Apprécier et évaluer les réponses des sujets lombalgiques chroniques très douloureux à une prise en charge dynamique et intensive. MÉTHODOLOGIE : 144 sujets atteints de lombalgie chronique ont été inclus dans un programme de restauration fonctionnelle du rachis de 5 semaines. Les sujets ont été classés en deux groupes de niveau de douleur: un groupe atteint de douleur sévère (n = 28) et un groupe atteint de douleur légère à modérée (n = 106). L’ensemble des sujets ont bénéficié d’une prise en charge identique comprenant principalement de la kinésithérapie, de l’ergothérapie, du reconditionnement musculaire et cardio-vasculaire ainsi qu’un suivi psychologique. Les paramètres physiques (flexibilité, force musculaire) et psychologiques (qualité de vie) ont été mesurés avant (T0) et après le programme (T5sem). RÉSULTATS : L’ensemble des performances physiques et fonctionnelles des sujets très douloureux sont moins bonnes et le retentissement de la lombalgie sur la qualité de vie, pour ces mêmes sujets, est majoré à T0. Toutes les différences significatives constatées à T0 entre les deux groupes s’effacent à T5sem. CONCLUSIONS : Les sujets lombalgiques chroniques très douloureux répondent favorablement au programme dynamique et intensif. L’intensité douloureuse de la lombalgie n’aurait pas d’effet sur les réponses au programme. La restauration fonctionnelle du rachis apporterait aux sujets la possibilité de mieux gérer leur douleur quel que soit son niveau. PMID:25299476

  2. Une angiocholite secondaire à un thrombus tumoral d'une tumeur neuroendocrine primitive du foie

    PubMed Central

    Baba, Hicham; Allaoui, Mohamed; Elfahssi, Mohammed; Bounaim, Ahmed; Ali, Abdelmounaim Ait; Oukabli, Mohamed; Sair, Khalid; Zentar, Aziz

    2015-01-01

    Nous rapportons le cas exceptionnel d'une patiente de 54 ans prise en charge pour une angiocholite due à un thrombus tumoral, d'une tumeur neuroendocrine primitive (TNE Ive) du foie, dans la voie biliaire principale. PMID:26966504

  3. Lymphome malin non hodgkinien du cavum: protocoles thérapeutiques et facteurs pronostiques

    PubMed Central

    Ouraini, Saloua; Nakkabi, Ismail; Benariba, Fouad

    2015-01-01

    Le lymphome malin non hodgkinien est une entité histologique rare parmi les cancers du cavum, la plupart des tumeurs du nasopharynx étant des carcinomes indifférenciés ou Undifferencied Carcinoma of Nasopharyngeal Type (UCNT); Il pose souvent un problème de diagnostic positif clinique et histologique. La symptomatologie est généralement peu spécifique et la démarche étiologique repose sur la biopsie du cavum faite à l'examen endoscopique avec examen immuno-histochimique. Nous rapportons le cas d'un lymphome non hodgkinien avec atteinte du nasopharynx, l'analyse anatomopathologique est en faveur d'un lymphome malin non hodgkinien de phénotype B. Les aspects cliniques, radiologiques, histologiques et thérapeutiques sont décrits. PMID:26889334

  4. Water-quality along selected flowpaths in the Prairie du Chien-Jordan aquifer, southeastern Minnesota

    SciTech Connect

    Smith, S.E. )

    1994-04-01

    The Prairie du Chien-Jordan aquifer in southeastern Minnesota is comprised of the dolomitic Prairie du Chien Group and the underlying Jordan Sandstone. Differences in water quality between the Prairie du Chien and the Jordan parts of the aquifer were investigated by sampling 139 wells in six study areas within Hennepin, Dakota, and Olmsted Counties. The study areas, which represent paths of groundwater flow through the aquifer, averaged 13 miles long and 3 miles wide. The wells were screened in the Jordan, Prairie du Chien, and overlying aquifers. Concentrations of tritium, nitrite plus nitrate nitrogen, and chloride were useful indicators of the actual and potential extent of human-related contamination of the aquifer. Differences in water quality were related to land use, aquifer permeability, thickness and lithology of overlying units, presence of confining units, flow path length, and well construction. Water samples from wells completed in the Jordan aquifer have lower tritium, nitrite plus nitrate nitrogen, and chloride concentrations than samples from wells completed in the overlying Prairie du Chien, St. Peter, and glacial drift aquifers. The distribution of these indicators on vertical sections of the aquifer, geochemical analysis of saturation indices (WATEQF), piper diagrams, and statistical analyses were used to analyze the hydrogeology and sensitivity to contamination of the Prairie du Chien-Jordan aquifer.

  5. A yeast artificial chromosome contig of the critical region for cri-du-chat syndrome

    SciTech Connect

    Goodart, S.A.; Rojas, K.; Overhauser, J.

    1994-11-01

    Cri-du-chat is a chromosomal deletion syndrome characterized by partial deletion of the short arm of chromosome 5. The clinical symptoms include growth and mental retardation, microcephaly, hypertelorism, epicanthal folds, hyptonia, and a high-pitched monochromatic cry that is usually considered diagnostic for the syndrome. Recently, a correlation between clinical features and the extent of the chromosome 5 deletions has identified two regions of the short arm that appear to be critical for the abnormal development manifested in this syndrome. Loss of a small region in 5p15.2 correlates with all of the clinical features of cri-du-chat with the exception of the cat-like cry, which maps to 5p15.3. Here the authors report the construction of a YAC contig that spans the chromosomal region in 5p15.2 that plays a major role in the etiology of the cri-du-chat syndrome. YACs that span the 2-Mb cri-du-chat critical region have been identified and characterized. This YAC contig lays the groundwork for the construction of a transcriptional map of this region and the eventual identification of genes involved in the clinical features associated with the cri-du-chat syndrome. It also provides a new diagnostic tool for cri-du-chat in the shape of a YAC clone that may span the entire critical region. 24 refs., 4 figs., 2 tabs.

  6. Prise en charge des traumatismes graves du rein

    PubMed Central

    Lakmichi, Mohamed Amine; Jarir, Redouane; Sadiki, Bader; Zehraoui; Bentani; Wakrim, Bader; Dahami, Zakaria; Moudouni; Sarf, Ismail

    2015-01-01

    Les traumatismes graves du rein de grade III, IV et V selon la classification de l'Amercan Society for Surgery For Trauma (ASST) sont plus rares et se retrouvent dans 5% des cas en moyenne. Leur prise en charge est souvent délicate, nécessitant alors des centres expérimentés dotés de moyen adéquats d'imagerie (scanner spiralé). Cependant, durant ces dernières années, la prise en charge de ces traumatismes a évolué vers une attitude de moins en moins chirurgicale grâce à l’évolution des techniques de la radiologie interventionnelle, de l'endourologie et des moyens de surveillance aux urgences et de réanimation. L'objectif de cette étude est d’évaluer notre expérience dans la prise en charge des traumatismes rénaux de haut grade. Notre étude rétrospective porte sur 25 cas de traumatismes grave du rein de grade III, IV et V selon la classification de l'ASST, colligés entre Janvier 2002 et Juin 2009 au service d'urologie du centre Hospitalier Universitaire Mohammed VI, Université Cadi Ayyad de Marrakech, Maroc. Nous avons étudié les données épidémiologiques, les signes cliniques et biologiques à l'admission (état de choc hémorragique, taux d'hémoglobine), les données radiologiques (échographie et scanner), les lésions associées, la prise en charge thérapeutique et les complications. L’âge moyen de nos patients était de 24,9 ans 15 et 58 ans, avec une prédominance masculine (sex-ratio = 7, 3). Le rein droit était intéressé dans 15 cas (60%). Le traumatisme rénal était fermé dans 15 cas, et ouvert par arme blanche dans 10 cas. Huit patients se sont présentés en état de choc hémorragique (32%). Une anémie inférieur à 10g /100ml a été observée dans 10 cas (40%). L'uroscanner fait systématiquement à l'admission a retrouvé un grade III (10 cas), grade IV (13 cas) et grade V (2 cas). La prise en charge a consisté en une exploration chirurgicale avec néphrectomie chez 2 cas de Grade IV pour une instabilité h

  7. Characterizing the secondary hydration shell on hydrated myoglobin, hemoglobin, and lysozyme powders by its vitrification behavior on cooling and its calorimetric glass-->liquid transition and crystallization behavior on reheating.

    PubMed Central

    Sartor, G; Hallbrucker, A; Mayer, E

    1995-01-01

    For hydrated metmyoglobin, methemoglobin, and lysozyme powders, the freezable water fraction of between approximately 0.3-0.4 g water/g protein up to approximately 0.7-0.8 g water/g protein has been fully vitrified by cooling at rates up to approximately 1500 K min-1 and the influence of cooling rate characterized by x-ray diffractograms. This vitreous but freezable water fraction started to crystallize at approximately 210 K to cubic ice and at approximately 240 K to hexagonal ice. Measurements by differential scanning calorimetry have shown that this vitreous but freezable water fraction undergoes, on reheating at a rate of 30 K min-1, a glass-->liquid transition with an onset temperature of between approximately 164 and approximately 174 K, with a width of between approximately 9 and approximately 16 degrees and an increase in heat capacity of between approximately 20 and approximately 40 J K-1 (mol of freezable water)-1 but that the glass transition disappears upon crystallization of the freezable water. These calorimetric features are similar to those of water imbibed in the pores of a synthetic hydrogel but very different from those of glassy bulk water. The difference to glassy bulk water's properties is attributed to hydrophilic interaction and H-bonding of the macromolecules' segments with the freezable water fraction, which thereby becomes dynamically modified. Abrupt increase in minimal or critical cooling rate necessary for complete vitrification is observed at approximately 0.7-0.8 g water/g protein, which is attributed to an abrupt increase of water's mobility, and it is remarkably close to the threshold value of water's mobility on a hydrated protein reported by Kimmich et al. (1990, Biophys. J. 58:1183). The hydration level of approximately 0.7-0.8 g water/g protein is approximately that necessary for completing the secondary hydration shell. PMID:8599674

  8. Berberine-induced anticancer activities in FaDu head and neck squamous cell carcinoma cells.

    PubMed

    Seo, Yo-Seob; Yim, Min-Ji; Kim, Bok-Hee; Kang, Kyung-Rok; Lee, Sook-Young; Oh, Ji-Su; You, Jae-Seek; Kim, Su-Gwan; Yu, Sang-Joun; Lee, Gyeong-Je; Kim, Do Kyung; Kim, Chun Sung; Kim, Jin-Soo; Kim, Jae-Sung

    2015-12-01

    In the present study, we investigated berberine‑induced apoptosis and the signaling pathways underlying its activity in FaDu head and neck squamous cell carcinoma cells. Berberine did not affect the viability of primary human normal oral keratinocytes. In contrast, the cytotoxicity of berberine was significantly increased in FaDu cells stimulated with berberine for 24 h. Furthermore, berberine increased nuclear condensation and apoptosis rates in FaDu cells than those in untreated control cells. Berberine also induced the upregulation of apoptotic ligands, such as FasL and TNF-related apoptosis-inducing ligand, and triggered the activation of caspase-8, -7 and -3, and poly(ADP ribose) polymerase, characteristic of death receptor-dependent extrinsic apoptosis. Moreover, berberine activated the mitochondria‑dependent apoptotic signaling pathway by upregulating pro-apoptotic factors, such as Bax, Bad, Apaf-1, and the active form of caspase-9, and downregulating anti-apoptotic factors, such as Bcl-2 and Bcl-xL. In addition, berberine increased the expression of the tumor suppressor p53 in FaDu cells. The pan-caspase inhibitor Z-VAD-fmk suppressed the activation of caspase-3 and prevented cytotoxicity in FaDu cells treated with berberine. Interestingly, berberine suppressed cell migration through downregulation of vascular endothelial growth factor (VEGF), matrix metalloproteinase (MMP)-2, and MMP-9. Moreover, the phosphorylation of extracellular signal-regulated kinase (ERK1/2) and p38, components of the mitogen-activated protein kinase pathway that are associated with the expression of MMP and VEGF, was suppressed in FaDu cells treated with berberine for 24 h. Therefore, these data suggested that berberine exerted anticancer effects in FaDu cells through induction of apoptosis and suppression of migration. Berberine may have potential applications as a chemotherapeutic agent for the management of head and neck squamous carcinoma. PMID:26503508

  9. Resistivity tomography of Pointe du Hoc cliffs for stability assessment

    NASA Astrophysics Data System (ADS)

    Udphuay, S.; Everett, M. E.; Warden, R.

    2008-12-01

    Pointe du Hoc WWII battlefield overlooking the English Channel in western Normandy, France, is an important cultural resource, being an integral component of the June 6 1944 D-Day invasion. Two major buildings, the forward observation post (OP) and Col. Rudder's command post (RCP), are now perched perilously close to the cliff's edge owing to six decades of cliff retreat. Geophysical surveys were carried out in March 2008 to investigate the risk of cliff failure and to inform possible geotechnical remediation strategies with a final goal toward re-opening the observation post that is now closed to visitors. The geophysical surveying is accomplished by high-resolution resistivity tomography, conducted in extreme topography and in the midst of dense cultural clutter. The results of the OP tomography indicate that the highest mass movement hazard is associated with the marine caverns at the base of the cliff at the point of strongest wave attack. These caverns occupy the future site of a sea arch which will threaten the OP building. There is a high probability of a soil wedge failure on the east facing cliff edge close to the OP building. Such a failure could damage or destroy the building. The possibility of a sudden catastrophic failure along any one of these fractures cannot be ruled out. The greatest risk at the RCP site, which is under less immediate threat, is associated with soil wedge failures at the top of the cliffs.

  10. Identification d'une loi thermo-élasto-viscoplastique en vue de la modélisation du laminage à chaud du cuivre

    NASA Astrophysics Data System (ADS)

    Moureaux, P.; Moto Mpong, S.; Remy, M.; Bouffioux, C.; Lecomte-Beckers, J.; Habraken, A. M.

    2002-12-01

    la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La collecte d'informations précises tant sur le procédé industriel que sur le comportement du matériau est par contre une opération non triviale. Cet article présente les diverses méthodes expérimentales mises en œuvre pour caractériser le matériau : essais de compression à chaud, mesures d'analyse thermique différentielle, essais de dilatométrie et de diffusivité. Les méthodes permettant d'identifier les paramètres de la loi élasto-visco-plastique de type Norton-Hoff à partir des essais sont présentées et une analyse bibliographique investigue le problème de la détermination du module de Young à haute température. Tant les hypothèses supplémentaires relatives au procédé et nécessaires au modèle que les résultats finaux sont résumés.

  11. Modelisation frequentielle de la permittivite du beton pour le controle non destructif par georadar

    NASA Astrophysics Data System (ADS)

    Bourdi, Taoufik

    Le georadar (Ground Penetrating Radar (GPR)) constitue une technique de controle non destructif (CND) interessante pour la mesure des epaisseurs des dalles de beton et la caracterisation des fractures, en raison de ses caracteristiques de resolution et de profondeur de penetration. Les equipements georadar sont de plus en plus faciles a utiliser et les logiciels d'interpretation sont en train de devenir plus aisement accessibles. Cependant, il est ressorti dans plusieurs conferences et ateliers sur l'application du georadar en genie civil qu'il fallait poursuivre les recherches, en particulier sur la modelisation et les techniques de mesure des proprietes electriques du beton. En obtenant de meilleures informations sur les proprietes electriques du beton aux frequences du georadar, l'instrumentation et les techniques d'interpretation pourraient etre perfectionnees plus efficacement. Le modele de Jonscher est un modele qui a montre son efficacite dans le domaine geophysique. Pour la premiere fois, son utilisation dans le domaine genie civil est presentee. Dans un premier temps, nous avons valide l'application du modele de Jonscher pour la caracterisation de la permittivite dielectrique du beton. Les resultats ont montre clairement que ce modele est capable de reproduire fidelement la variation de la permittivite de differents types de beton sur la bande de frequence georadar (100 MHz-2 GHz). Dans un deuxieme temps, nous avons montre l'interet du modele de Jonscher en le comparant a d'autres modeles (Debye et Debye-etendu) deja utilises dans le domaine genie civil. Nous avons montre aussi comment le modele de Jonscher peut presenter une aide a la prediction de l'efficacite de blindage et a l'interpretation des ondes de la technique GPR. Il a ete determine que le modele de Jonscher permet de donner une bonne presentation de la variation de la permittivite du beton dans la gamme de frequence georadar consideree. De plus, cette modelisation est valable pour differents

  12. A Description of Adaptive and Maladaptive Behaviour in Children and Adolescents with Cri-du-Chat Syndrome

    ERIC Educational Resources Information Center

    Teixeira, M. C. T. V.; Emerich, D. R.; Orsati, F. T.; Rimerio, R. C.; Gatto, K. R.; Chappaz, I. O.; Kim, C. A.

    2011-01-01

    Background: Psychological tests can be useful to record adaptive and maladaptive behaviours of children with intellectual disability. The objective of this study was to describe the adaptive and maladaptive behaviour of children and adolescents with Cri-du-chat syndrome. Methods: The sample consisted of 10 children and adolescents with Cri-du-chat…

  13. Graphs as a Managerial Tool: A Case Study of Du Pont's Use of Graphs in the Early Twentieth Century.

    ERIC Educational Resources Information Center

    Yates, JoAnne

    1985-01-01

    Sketches the development of business graphs in America. Examines their early use at Du Pont and the origin of the chart room around 1920, an important factor in the executive control systems at Du Pont. Draws lessons from this case study for managers and teachers of business communication. (PD)

  14. La genèse du concept de champ quantique

    NASA Astrophysics Data System (ADS)

    Darrigol, O.

    This is a historical study of the roots of a concept which has proved to be essential in modern particle physics : the concept of quantum field. The first steps were accomplished by two young theoreticians : Pascual Jordan quantized the free electromagnetic field in 1925 by means of the formal rules of the just discovered matrix mechanics, and Paul Dirac quantized the whole system charges + field in 1927. Using Dirac's equation for electrons (1928) and Jordan's idea of quantized matter waves (second quantization), Werner Heisenberg and Wolfgang Pauli provided in 1929-1930 an extension of Dirac's radiation theory and the proof of its relativistic invariance. Meanwhile Enrico Fermi discovered independently a more elegant and pedagogical formulation. To appreciate the degree of historical necessity of the quantization of fields, and the value of contemporaneous critics to this approach, it was necessary to investigate some of the history of the old radiation theory. We present the various arguments however provisional or naïve or wrong they could be in retrospect. So we hope to contribute to a more vivid picture of notions which, once deprived of their historical setting, might seem abstruse to the modern user. Nous présentons une étude historique des origines d'un concept devenu essentiel dans la physique moderne des particules : le concept de champ quantique. Deux jeunes théoriciens franchirent les premières étapes : Pascual Jordan quantifia le champ électromagnétique en 1925 grâce aux règles formelles de la mécanique des matrices naissante, et Paul Dirac quantifia le système complet charges + champ en 1927. Au moyen de l'équation de l'électron de Dirac (1928) et de l'idée de Jordan d'ondes de matière quantifiées (deuxième quantification), Werner Heisenberg et Wolfgang Pauli donnèrent en 1929-1930 une extension de la théorie du rayonnement de Dirac et la preuve de son invariance relativiste. Pendant ce temps Enrico Fermi découvrit ind

  15. Pc2-mediated SUMOylation of WWOX is essential for its suppression of DU145 prostate tumorigenesis.

    PubMed

    Choi, Hye-Jin; Park, Jung-Hwan; Park, Jong-Hwan; Lee, Kyung Bok; Oh, Sang-Muk

    2015-12-21

    Tumor suppressor WW domain-containing oxidoreductase (WWOX) is depleted in various cancer types. Here we report that WWOX is modified by small ubiquitin-like modifier (SUMO) proteins and represses DU145 prostate cancer tumorigenesis in a SUMOylation-dependent manner. Ectopic WWOX was shown to associate with SUMO2/3 or E2 Ubc9. Furthermore, we revealed that WWOX SUMOylation was promoted by E3 ligase polycomb2 (Pc2), and that WWOX associated with Pc2. Meanwhile, anisomycin-induced activator protein-1 (AP-1) activity was markedly diminished by co-expression of SUMO and WWOX. Also, WWOX wild type (WT), but not WWOX SUMO mutant (K176A) markedly reduced both DU145 prostate cancer cell proliferation and xenograft tumorigenesis. Collectively, our findings demonstrate that SUMO modification of WWOX is essential for its suppressive activity for DU145 prostate cancer tumorigenesis. PMID:26592150

  16. Purification, identification and preliminary crystallographic studies of Pru du amandin, an allergenic protein from Prunus dulcis

    SciTech Connect

    Gaur, Vineet; Sethi, Dhruv K.; Salunke, Dinakar M.

    2008-01-01

    The purification, identification, crystallization and preliminary crystallographic studies of an allergy-related protein, Pru du amandin, from P. dulcis nuts are reported. Food allergies appear to be one of the foremost causes of hypersensitivity reactions. Nut allergies account for most food allergies and are often permanent. The 360 kDa hexameric protein Pru du amandin, a known allergen, was purified from almonds (Prunus dulcis) by ammonium sulfate fractionation and ion-exchange chromatography. The protein was identified by a BLAST homology search against the nonredundant sequence database. Pru du amandin belongs to the 11S legumin family of seed storage proteins characterized by the presence of a cupin motif. Crystals were obtained by the hanging-drop vapour-diffusion method. The crystals belong to space group P4{sub 1} (or P4{sub 3}), with unit-cell parameters a = b = 150.7, c = 164.9 Å.

  17. Contribution de l'altimetrie satellitaire a l'etude de la variabilite du niveau d'eau du Delta interieur du fleuve Niger

    NASA Astrophysics Data System (ADS)

    Telly Diepkile, Adama

    measurements were then corrected to bring them in the same altimetry reference level as Topex/Poseidon, thereby producing time series of 17 years (1992-2009). Following this analysis, we proposed a waveform retracking algorithm that integrates the backscattering coefficient to the time scale of penetration of the radar pulse in a medium with a presence of vegetation. The idea here is to consider the heterogeneity of a medium such as the Delta, which can be covered with vegetation. For this, we introduce into the equation of the waveform, the backscattering coefficient estimated from the so called water cloud model, to create a new algorithm called retracking algorithm of water cloud. This algorithm was applied to the Envisat and OSTM/Jason-2 data. The results of the algorithm were validated with in situ measurements of the Direction Nationale de l'Hydraulique du Mali and also with measurements acquired during a campaign of data collection conducted between August and October 2009. The observed differences are generally small (<+/- 1 m). The retracking algorithm of water cloud was compared to other existing algorithms. It shows a strong correlation with Ice-1 (R 2 = 0,84). Finally, we analyzed the influence of precipitation on the variations of the altimetry-derived water levels. Three sources of precipitations from satellite measurements and reanalysis data were considered in three catchments (basin Fouta Djallon in upstream, Bani basin and the inner basin in Mali). The analysis reveals the importance of precipitations, particularly in the basin of Fouta Djallon. Approximately 70% of sites analyzed in the Delta show a relatively strong correlation (R2 > 0,40) with the cumulative precipitations in the basins considered. Keywords : Remote Sensing, Satellite altimetry, Continental waters, Water level, Long term analysis, Inner Delta of Niger River, Water-cloud model, Envisat, Topex/Poseidon.

  18. Coronagraphy at Pic du Midi: Present state and future projects

    NASA Astrophysics Data System (ADS)

    Koechlin, L.

    2012-12-01

    The Pic du Midi coronagraph (CLIMSO) is a group of four instruments in parallel, taking images of the whole solar photosphere and low corona. It provides series of 2048*2048 pixels images taken nominally at 1 minute time intervals, all year long, weather permitting. A team of ≃q 60 persons, by groups of 2 or 3 each week, operate the instruments. Their work is programmed in collaboration with Institut de Recherches en astrophysique et planétologie (IRAP) of Observatoire Midi Pyrénées (OMP), and with Programme National Soleil Terre (PNST). The four instruments of CLIMSO (L1, C1, L2 and C2) collect images of the Sun as following: 1) L1 : photosphere in H-α (656.28 nm) ; 2) L2 : photosphere in Ca-II (393.37 nm) ; 3) C1 : prominences in H-α ; 4) C2 : prominences in He-I (1083.0 nm). The data taken are stored in fits format images and mpeg films. They are available publicly on data bases such as BASS 2000 Meudon ({http://bass2000.obspm.fr/home.php?lang=en} and BASS2000 Tarbes ({http://bass2000.bagn.obs-mip.fr/base/sun/index.php}). Several solar studies are carried in relation with these data. In addition to the raw fits images, new images will soon be sent to the data bases: they will be calibrated in solar surface emittance, expressed in W/m^2/nm/steradian. Series of mpeg films for each day are presented in superposed color layers, so as to visualize the multispectral information better. New instrumental developments are planned for the next years and already financed. They will use spectropolarimetry to measure the magnetic field and radial velocities in the photosphere and corona. The data will cover the entire solar disc and have a sample rate of one map per minute.

  19. Evaluation du niveau de connaissance des patients sur la gestion du traitement par les antis vitamines K dans le service de cardiologie de Ouagadougou

    PubMed Central

    Samadoulougou, André; Temoua Naibe, Dangwé; Mandi, Germain; Yameogo, Relwendé Aristide; Kabore, Elisé; Millogo, Georges; Yameogo, Nobila Valentin; Kologo, Jonas Koudougou; Thiam/Tall, Anna; Toguyeni, Boubacar Jean Yves; Zabsonre, Patrice

    2014-01-01

    Introduction Les antivitamines K (AVK), traitement anticoagulant oral le plus largement prescrit, posent un réel problème de santé publique du fait de leur risque iatrogène. L'objectif de cette étude était de préciser le niveau de connaissance des patients sur la gestion de leur traitement par les AVK. Méthodes Il s'est agi d'une enquête transversale descriptive réalisée au CHU-Yalgado Ouédraogo, sur une période de 03 mois : du 1er mars au 31 mai 2012. Un questionnaire a été administré aux patients bénéficiant d'un traitement AVK depuis au moins un mois. Résultats Soixante-dix patients ont été inclus dans l'étude dont 30 hommes. L'âge moyen était de 49 ans ± 16 ans. Les cardiopathies et la maladie thromboembolique veineuse justifiant l'institution du traitement AVK étaient retrouvées respectivement dans 58,6% et 41,4% des cas. Le nom de l'AVK et la raison exacte du traitement étaient connus respectivement dans 91,4% et 67,1% des cas. Plus de la moitié des patients (68,6%) savaient que les AVK rendaient le sang plus fluide. Quarante-six patients (65,7%) citaient l'INR comme examen biologique de surveillance du traitement et seulement 28 patients (40%) connaissaient les valeurs cibles. La majorité des patients ne connaissait pas les risques encourus en cas de surdosage (72,8%) et de sous-dosage (71,4%). Une automédication par anti-inflammatoire non stéroïdien était signalée par 18 patients (25,7%). Les choux (74,3%) et la laitue (62,9%), aliments à consommer avec modération, étaient les plus cités. Conclusion Les connaissances des patients sur la gestion des AVK étaient fragmentaires et insuffisantes pour assurer la sécurité et l'efficacité du traitement. La création d'un programme d'éducation thérapeutique sur les AVK s'avère alors nécessaire. PMID:25870741

  20. Long-term corrosion and leaching of depleted uranium (DU) in soil.

    PubMed

    Schimmack, W; Gerstmann, U; Schultz, W; Geipel, G

    2007-08-01

    Corrosion and leaching of depleted uranium (DU) was investigated for 3 years using six DU munitions (145-264 g DU) each buried in a column with a soil core of about 3.3 kg dry soil mass. The columns were installed in an air-conditioned laboratory. Each week they were irrigated and (238)U was determined in the effluents by inductively coupled plasma mass spectrometry. In addition, (235)U was measured occasionally to assure that the (238)U was predominantly from the DU munition. On average, 14.5 g corresponding to 7.9% of the initial DU mass was corroded after 3 years, indicating an increased corrosion as compared to the first year of observation. The leaching rates increased much stronger than the corrosion rates by factors of more than 100, resulting in a mean total amount of leached (238)U of 13 mg as compared to 0.03 mg after the first year. Uranium species identified in the seepage water by time-resolved laser-induced fluorescence spectroscopy were mainly hydroxo and carbonate compounds, while those in the corroded material were phosphate compounds. It is concluded that the dramatic increase of the leaching and its large temporal variability do not allow any extrapolation for the future. However, the high (238)U concentrations observed in the seepage water highlight the need for further investigations on the transport of (238)U through soil, in particular with regard to the potential future (238)U contamination of groundwater in areas affected by DU weapons. PMID:17549506

  1. In vitro and in vivo antimycobacterial activities of a new quinolone, DU-6859a.

    PubMed Central

    Saito, H; Tomioka, H; Sato, K; Dekio, S

    1994-01-01

    A new fluoroquinolone, DU-6859a, was studied for its in vitro and in vivo antimycobacterial activities. MIC determination by the agar dilution method with 7H11 medium revealed that DU-6859a had MICs at which 90% of M. kansasii (0.78 microgram/ml), M. marinum (1.56 micrograms/ml), M. scrofulaceum (1.56 micrograms/ml), M. fortuitum (0.39 microgram/ml), M. chelonae subsp. abscessus (6.25 micrograms/ml), and M. chelonae subsp. chelonae (1.56 micrograms/ml) were inhibited were 4 to 32 times lower than those of ofloxacin and sparfloxacin. The MICs of DU-6859a at which 90% of M. tuberculosis (0.2 microgram/ml) and M. avium-M. intracellulare complex (12.5 micrograms/ml each) were inhibited were comparable to those of sparfloxacin but were four- to eightfold lower than those of ofloxacin. Thus, DU-6859a possessed more potent in vitro activity than sparfloxacin and ofloxacin against most mycobacterial species. DU-6859a exerted significant efficacy against infections caused by M. intracellulare and M. chelonae subsp. abscessus induced in mice when it was given at a dose of 1 mg per mouse (ca. 50 mg/kg of body weight) in terms of reducing the frequency of occurrence and the degree of gross pulmonary or renal lesions and bacterial loads in the lungs, spleens, or kidneys. The efficacy of DU-6859a was greater than that of ofloxacin and was more pronounced against M. chelonae infections than against M. intracellulare infections. PMID:7695276

  2. Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells

    PubMed Central

    OGURA, TAKEHARU; TANAKA, YOSHIYUKI; TAMAKI, HIROKI; HARADA, MAMORU

    2016-01-01

    Docetaxel is a useful chemotherapeutic agent for the first-line treatment of hormone-refractory prostate cancer. Abnormal expression of Bcl-2 is commonly found in cancer cells, which increases their anti-apoptotic potency and chemo-resistance. We investigated the effects of Bcl-2 expression status on the susceptibility of DU145 cells, an androgen-independent human prostate cancer cell line, to docetaxel and other anticancer agents. A panel of Bcl-2-expressing DU145 cell lines was established. Bcl-2 expression levels were unrelated to the susceptibility of DU145 cells to docetaxel. The sensitivity of DU145 cells to cisplatin fluctuated, and the sensitivity to tumor necrosis factor (TNF)-α was decreased by Bcl-2 overexpression. In a xenograft mouse model, overexpression of Bcl-2 drastically decreased the sensitivity of DU145 cells to cisplatin and TNF-α; however, there was no change in the response to docetaxel. Fluorescent microscopy revealed that Bcl-2-overexpression had no effect on the docetaxel-induced death of DU145 cells, but significantly decreased DU145 cell death induced by cisplatin or TNF-α. Interestingly, docetaxel hardly induced caspase-3/7 activation in control or Bcl-2-overexpressing DU145 cells, but did at a low level in LNCaP cells, another prostate cancer cell line. Moreover, in contrast to LNCaP cells, the reduced viabilities of docetaxel-treated control and Bcl-2-overexpressing DU145 cells were not restored by the addition of either a Bid inhibitor or a panel of pro-apoptotic caspase inhibitors. These findings indicate that the antitumor effects of docetaxel on DU145 cells are independent of both Bcl-2 and pro-apoptotic caspases. PMID:27082738

  3. Docetaxel induces Bcl-2- and pro-apoptotic caspase-independent death of human prostate cancer DU145 cells.

    PubMed

    Ogura, Takeharu; Tanaka, Yoshiyuki; Tamaki, Hiroki; Harada, Mamoru

    2016-06-01

    Docetaxel is a useful chemotherapeutic agent for the first-line treatment of hormone-refractory prostate cancer. Abnormal expression of Bcl-2 is commonly found in cancer cells, which increases their anti-apoptotic potency and chemoresistance. We investigated the effects of Bcl-2 expression status on the susceptibility of DU145 cells, an androgen-independent human prostate cancer cell line, to docetaxel and other anticancer agents. A panel of Bcl-2-expressing DU145 cell lines was established. Bcl-2 expression levels were unrelated to the susceptibility of DU145 cells to docetaxel. The sensitivity of DU145 cells to cisplatin fluctuated, and the sensitivity to tumor necrosis factor (TNF)-α was decreased by Bcl-2 overexpression. In a xenograft mouse model, overexpression of Bcl-2 drastically decreased the sensitivity of DU145 cells to cisplatin and TNF-α; however, there was no change in the response to docetaxel. Fluorescent microscopy revealed that Bcl-2-overexpression had no effect on the docetaxel-induced death of DU145 cells, but significantly decreased DU145 cell death induced by cisplatin or TNF-α. Interestingly, docetaxel hardly induced caspase-3/7 activation in control or Bcl-2-overexpressing DU145 cells, but did at a low level in LNCaP cells, another prostate cancer cell line. Moreover, in contrast to LNCaP cells, the reduced viabilities of docetaxel-treated control and Bcl-2-overexpressing DU145 cells were not restored by the addition of either a Bid inhibitor or a panel of pro-apoptotic caspase inhibitors. These findings indicate that the antitumor effects of docetaxel on DU145 cells are independent of both Bcl-2 and pro-apoptotic caspases. PMID:27082738

  4. Dépistage précoce des retards du développement moteur

    PubMed Central

    Harris, Susan R.

    2016-01-01

    Résumé Objectif Décrire le test HINT (Harris Infant Neuromotor Test), un test d’évaluation du développement neuromoteur chez les nourrissons publié en 2010, qui s’appuie sur les normes canadiennes et peut être utilisé pour dépister les retards du développement moteur durant la première année de la vie. Qualité des données D’abondantes recherches ont été publiées sur la fiabilité intra-évaluateur, inter-évaluateur et test-retest ainsi que sur la validité convergente, prédictive, du contenu et des groupes connus du test HINT, de même que sur la sensibilité, la spécificité et les valeurs prédictives négatives et positives des inquiétudes des parents, telles qu’évaluées par le test HINT. La plupart des données probantes sont de niveau II. Message principal Il est important de diagnostiquer les retards du développement moteur durant la première année de vie, car ils sont souvent le signe de retards du développement généralisés ou de déficiences précises, telles que la paralysie cérébrale. Les inquiétudes des parents quant au développement moteur de leur enfant sont une valeur prédictive robuste de diagnostics subséquents de retard du développement moteur. Conclusion Seul le dépistage précoce des retards du développement moteur, initialement par l’entremise d’outils de dépistage comme le test HINT, permet de recommander le patient à une intervention précoce qui profiterait tant à l’enfant qu’à sa famille. PMID:27521405

  5. PHOTOMETRIC ANALYSIS OF HS Aqr, EG Cep, VW LMi, AND DU Boo

    SciTech Connect

    Djurasevic, G.; Latkovic, O.; Bastuerk, Oe.; Y Latin-Small-Letter-Dotless-I lmaz, M.; Cal Latin-Small-Letter-Dotless-I skan, S.; Senavc Latin-Small-Letter-Dotless-I , H. V.; K Latin-Small-Letter-Dotless-I l Latin-Small-Letter-Dotless-I coglu, T.; Ekmekci, F.; Tanr Latin-Small-Letter-Dotless-I verdi, T.

    2013-03-15

    We analyze new multicolor light curves for four close late-type binaries: HS Aqr, EG Cep, VW LMi, and DU Boo, in order to determine the orbital and physical parameters of the systems and estimate the distances. The analysis is done using the modeling code of G. Djurasevic, and is based on up-to-date measurements of spectroscopic elements. All four systems have complex, asymmetric light curves that we model by including bright or dark spots on one or both components. Our findings indicate that HS Aqr and EG Cep are in semi-detached, while VW LMi and DU Boo are in overcontact configurations.

  6. DuPont/HFM forum on carpet in health care facilities.

    PubMed

    1994-02-01

    DuPont and Health Facilities Management magazine invited 20 national experts to Dalton, GA--the carpet-manufacturing capital of the world--last year to take part in Dupont's first-ever Forum on Carpet in Health Care Facilities. During the two-hour roundtable discussion, moderated by DuPont's C. Jack Murph and HFM's Michael Hemmes, ender-users, interior designers and carpet mill representatives talked about the aesthetic, economic and performance aspects of using carpet in health care settings. Here's an edited version of what they said. PMID:10131499

  7. Teton Wilderness, Teton Corridor, and Du Noir addition to Washakie Wilderness, Wyoming

    SciTech Connect

    Antweiler, J.C.; Williams, F.E.

    1984-01-01

    Field investigations were conducted during the summers of 1972, 1973, and 1974 by the USGS and the USBM to evaluate the mineral-resource potential of the Teton Wilderness, the Teton Corridor, and the Du Noir Addition to the Washakie Wilderness. As a result of this study it was determined that there is little promise for the occurrence of metallic mineral resources, but there is probable potential for oil and gas resources in two anticlines in the western part of the Teton Wilderness and in the postulated Younts Basin in the eastern part of the wilderness and the eastern part of the Du Noir Addition. The Whetstone anticline is the largest.

  8. Intubation Difficile Chez le Brule de la Face et du Cou a la Phase de Sequelles

    PubMed Central

    Siah, S.; El Wali, A.; Ababou, K.; Nassim Sabah, T.; Drissi, N.K.; Ihrai, I.

    2006-01-01

    Summary L'intubation trachéale chez le brûlé de la face et du cou au stade de séquelles peut être difficile voire impossible chez certains patients. La technique de ventilation à l'aide d'un masque laryngé ou d'intubation avec un fibroscope bronchique permet de résoudre la plupart des problèmes d'intubation difficile. Les Auteurs rapportent deux observations chez deux patientes porteuses de séquelles de brûlures de la face et du cou. PMID:21991028

  9. Nanobridge SQUIDs as calorimetric inductive particle detectors

    NASA Astrophysics Data System (ADS)

    Gallop, John; Cox, David; Hao, Ling

    2015-08-01

    Superconducting transition edge sensors (TESs) have made dramatic progress since their invention some 65 years ago (Andrews et al 1949 Phys. Rev. 76 154-155 Irwin and Hilton 2005 Topics Appl. Phys. 99 63-149) until now there are major imaging arrays of TESs with as many as 7588 separate sensors. These are extensively used by astronomers for some ground-breaking observations (Hattori et al 2013 Nucl. Instrum. Methods Phys. Res. A 732 299-302). The great success of TES systems has tended to overshadow other superconducting sensor developments. However there are other types (Sobolewski et al 2003 IEEE Trans. Appl. Supercond. 13 1151-7 Hadfield 2009 Nat. Photonics 3 696-705) which are discussed in papers within this special edition of the journal. Here we describe a quite different type of detector, also applicable to single photon detection but possessing possible advantages (higher sensitivity, higher operating temperature) over the conventional TES, at least for single detectors.

  10. Calorimetric measurement of energy of ultrasonic cleaners

    SciTech Connect

    Harding, W.B.

    1994-11-01

    The development of a calorimeter that measured the power within an ultrasonic cleaning tank is presented. The principle involved is explained. Several types of calorimeter that were tested are described. Measurement of the power in an ultrasonic cleaner permits: (1) comparing different ultrasonic cleaners; (2) monitoring the performance of a specific cleaner; (3) measuring the distribution of power in a cleaning tank, and (4) evaluating the effects of process variables on the power.

  11. La nutrition du nourrisson né à terme et en santé

    PubMed Central

    1998-01-01

    La nutrition du nourrisson né à terme et en santé constitue le nouvel énoncé national sur la nutrition du nourrisson, de la naissance à l’âge de 24 mois. Il s’agit d’un projet conjoint de la Société canadienne de pédiatrie, des Diététistes du Canada et de Santé Canada. Cet ouvrage est une synthèse de la documentation scientifique actuelle en matière de nutrition du nourrisson ; il contient des principes et recommandations afin d’aider les professionnels de la santé à promouvoir la prestation des meilleurs soins alimentaires possibles pour les nourrissons du Canada, compte tenu de l’état actuel de la recherche. La collaboration entre les trois principaux organismes qui s’intéressent à cette question a permis d’uniformisé le message que les professionnels transmettront au public. Le document aborde quatre grands sujets relatifs à la première année d’existence : l’allaitement, les laits de remplacement, les autres liquides dans le régime du nourrisson et la transition aux aliments solides. On y examine ensuite la question de la sécurité dans l’alimentation, puis celle de la nutrition durant la deuxième année. La dernière section couvre les autres questions liées à la nutrition du nourrisson ; on y traite de sujets tels que les allergies alimentaires, les coliques, la constipation, les matières grasses dans le régime alimentaire, la carie dentaire, la gastroentérite, le diabète, l’anémie ferriprive et les régimes végétariens. Le document contient également un répertoire complet de plus de 200 citations. Le sommaire des principes et recommandations paraîtra dans les revues officielles de la Société canadienne de pédiatrie (Paediatrics and Child Health, 1998) et des Diététistes du Canada (Revue canadienne de pratique et de recherche en diététique, juin 1998). On peut télécharger le document intégral à partir des sites Web respectifs des trois organismes associés ; on peut aussi obtenir la

  12. Two-generation reproductive toxicity study of implanted depleted uranium (DU) in CD rats.

    PubMed

    Arfsten, D P; Still, K R; Wilfong, E R; Johnson, E W; McInturf, S M; Eggers, J S; Schaeffer, D J; Bekkedal, M Y-V

    2009-01-01

    Depleted uranium (DU) munitions and armor plating have been used in several conflicts over the last 17 yr, including the Persian Gulf War and the Iraq War. Because of its effectiveness and availability, DU will continue to be used in military applications into the foreseeable future. There is much controversy over the use of DU in weapons and equipment because of its potential radiological and toxic hazards, and there is concern over the chronic adverse health effects of embedded DU shrapnel in war veterans and bystanders. This study evaluated the effects of long-term implantation of DU on the reproductive success of F0 generation adults and development and survival of subsequent F1 and F2 generations in a two-generation reproductive toxicity study. F0 generation Sprague-Dawley rats, 8 wk of age, were surgically implanted with 0, 4, 8, 12, or 20 DU pellets (1 x 2 mm). Inert implant control animals were implanted with 12 or 20 tantallum (Ta) pellets. The F0 generation was then mated at 120 d post DU implantation. In the F0 generation, when measured on postimplantation d 27 and 117, uranium was present in the urine of DU-implanted animals in a dose-dependent manner. F0 reproductive success was similar across treatment groups and the maternal retrieval test revealed no changes in maternal behavior. DU implantation exerted no effect on the survival, health, or well-being of the F0 generation. Necropsy results of F0 animals were negative with the exception of a marked inflammatory response surrounding the implanted DU pellets. For the F1 generation, measures of F1 development through postnatal day (PND) 20 were unremarkable and no gross abnormalities were observed in F1 offspring. No uranium was detected in whole-body homogenates of PND 4 or PND 20 pups. Necropsy findings of F1 PND 20 pups were negative and no instances of ribcage malformation were observed in F1 PND 20 pups. Body weight and body weight gain of F1 rats through PND 120 were similar across treatment

  13. Influence d'une substitution partielle du ciment par du laitier de hauts fourneaux sur la résistance des mortiers en milieu acide

    NASA Astrophysics Data System (ADS)

    Achoura, D.; Lanos, Ch.; Jauberthie, R.; Redjel, B.

    2004-11-01

    Le stockage de produits chimiques dans du béton présente souvent des problèmes de durabilité dus aux attaques chimiques. Inévitablement les concentrations élevées sont les plus dangereuses. Le but de notre étude est de déterminer les changements de phases qui apparaissent dans le béton lorsqu'on substitue une partie du ciment par du laitier de haut fourneaux. Les échantillons sont conservés dans des solutions acides différents anions (HCl, H{2}SO{4}, H{3}PO{4} et CH{3}COOH) et différentes concentrations (0,1; 0,25 et 0,5M). Les formations qui apparaissent sont déterminées par diffraction X et observées au MEB. Les solutions sulfatiques conduisent à une formation de gypse en surface et d'ettringite au contact de la matrice cimentaire. Avec l'acide acétique, il y a formation de calcium acétate hydrate sous forme spongieuse tandis que, avec l'acide phosphatique, la formation de calcium hydrogeno phosphate hydrate est très superficielle. Enfin, avec l'acide chlorhydrique, la surface du mortier est recouverte de chlorure de calcium dihydrate et d'hydroxyde de fer. Les résistances mécaniques sont plus ou moins affectées par la concentration mais aussi et surtout par la nature des acides avec dans l'ordre le plus agressif H{2}SO{4} puis HCl et CH{3}COOH enfin peu de modification pour H{3}PO{4}.

  14. Effect of eletroacupuncture on DU-14 (Dazhui), DU-2 (Yaoshu), and Liv-13 (Zhangmen) on the survival of Wistar rats' dorsal skin flaps.

    PubMed

    Uema, Deise; Orlandi, Denise; Freitas, Raphael R; Rodgério, Tatiane; Yamamura, Ysao; Tabosa, Angela F

    2008-01-01

    The survival of skin flaps has great interest in many areas of Medicine. In practice, one of the most important complications in the use of skin flaps is the tissue ischemia, which frequently results in widespread necrosis and failure of the proposed treatments. The objective of this study was to evaluate the possible benefits of eletroacupuncture stimulation of the points DU-14 (Dazhui), DU-2 (Yaoshu), and Liv-13 (Zhangmen) over the skin flap survival of Wistar rats after 8 days of treatment. Forty male Wistar rats were allocated into four groups with 10 animals each. They were submitted to a surgical procedure in which a dorsal skin flap measuring 10 x 4 cm was elevated and then sutured back with a plastic barrier between the flap and the donor site. During the following 8 days, one group received electro stimulation in two "nonaccupoints" whereas the other one had the accupoints DU-14 (Dazhui), DU-2 (Yaoshu), and Liv-13 (Zhangmen) stimulated. After this period, the rats were killed and flaps were appraised qualitative and quantitatively. Data were evaluated with analysis of variance and to establish significance Fisher's PLSD test was used when analysis of variance showed P < .05. It was observed that electroacupuncture group presented a skin flap survival index remarkably larger than the others. It has also shown a better evolution during the 8 days PO, confirmed by the lowest rate of necrosis and absent area. In this experimental model, eletroacupuncture was an efficient method to preserve vitality and decrease dorsal skin flap necrosis on Wistar rats. PMID:18354293

  15. Modelisation des proprietes electromagnetiques de metamateriaux a base de reseaux de fils ferromagnetiques

    NASA Astrophysics Data System (ADS)

    Boucher, Vincent

    The main objective of this work is to establish analytical expressions for the effective permittivity and permeability of metamaterials based on arrays of ferromagnetic conducting wires. Specifically, we consider the case of axially magnetized wires of radius ranging from 10 nm to 100 mum, which are excited in the microwave frequency range (1-- 100 GHz) by electric and magnetic fields parallel and perpendicular to the axis of the wires, respectively. We place special emphasis on evaluating the potential of these ferromagnetic wire arrays to produce, over the same frequency range, simultaneous magnetic-field-tuneable electric and magnetic responses. First, our method of derivation requires solving the problem of the scattering and absorption of an electromagnetic wave by an individual wire, so as to obtain the dipolar responses of its dynamic polarization and magnetization in the regime of arbitrary skin effect. These responses are then incorporated into our homogenization procedure, in order to yield general expressions for the effective permittivity and permeability of the array, which depend upon the gyromagnetic and metallic properties of the wires, the geometrical parameters of the array, and the interwire dipolar interactions. Our results show that the consideration of skin effect is greatly simplified by introducing kwa-dependent renormalized expressions for the wire intrinsic properties, where kw is the complex amplitude of the wave vector inside the wires of radius a. Our expression for the effective permeability tensor of the array is a gyrotropic tensor, with diagonal and off-diagonal components expressed compactly in terms of renormalized permeability components which account for electromagnetic retardation inside the wires. It must be emphasized that our explicit treatment of both gyrotropy and electromagnetic retardation constitutes an extension of existing models, which are restricted to considering only one or the other of these two aspects. We also describe how the effective permeability of dense arrays of nanowires can be exploited by using semi-isolated wires, that is, wires for which electrical continuity is not maintained at either of their ends. Such arrays then behave as effective magnetic insulators but no longer show magnetodielectric effects. Hence, we conclude that the conditions under which arrays of ferromagnetic wires exhibit effective permittivity and permeability that are simultaneously significant and tuneable by a static magnetic field tend to be mutually exclusive. Next, we apply our theoretical formalism to the study of the effective permeability of dense arrays of nanowires (i.e., characterized by negligible skin effect) embedded in a dielectric membrane. In these arrays, the individual wires exhibit a bistable response as a function of the static axial magnetic field, so that when the array is partially demagnetized, the wires split into two oppositely magnetized populations, the relative proportions of which can be adjusted by using minor hysteresis cycles. Further, the presence of these two populations strongly modifies the effective permeability of the array, which may then display two distinct absorption peaks. In order to validate our effective permeability model, broadband microstrip line ferromagnetic resonance measurements (1--40 GHz) have been performed on an array of Co94Fe5B1 nanowires, of average diameter 45 nm, embedded into an alumina membrane of average interpore distance 110 nm. These show that the complex permeability spectra extracted from the experimental data are generally in excellent agreement with the theoretical spectra. In particular, the model accounts well for the dependence of the shape, amplitude, position, and width of the two-peak permeability spectra as a function of the applied static magnetic field and the remanent magnetization of the array. Discrepancies observed when the peaks are close to each other are attributed to spatial fluctuations of the local interaction field, which are not accounted for in our model. (Abstract shortened by UMI.)

  16. Aspects épidémiologiques du suicide à Dakar

    PubMed Central

    Soumah, Mohamed Maniboliot; Eboué, Brice Angwé; Ndiaye, Mor; Sow, Mamadou Lamine

    2013-01-01

    Introduction Le suicidé est le sujet mort par suicide et le suicidant est la personne ayant fait des tentatives de suicide. L'objectif de cette étude porte sur l'analyse épidémiologique des suicides dans la région de Dakar. Méthodes Par une étude rétrospective portant sur les registres du service d'anatomie pathologique de l'Hôpital Aristide Le Dantec, nous rapportons 143 suicides sur 10 ans. Le traitement et l'analyse des données ont été faits sur Epidata version 2.1 b pour la saisie et Epiinfo version 6.04 fr pour l'analyse. Résultats A Dakar, les morts par suicide restent peu fréquentes au regard de la mortalité générale. Les hommes se suicident deux fois plus que les femmes et le suicide reste l'apanage de l'adulte jeune dont l'âge se situe entre 21 et 30 ans. Les suicidés résident le plus souvent en zone périurbaine et ils commettent cet acte dans la majorité des cas en période de froid (pendant les mois de janvier, février et mars), plus avant midi et en soirée qu'en après-midi. Aussi 97.2% des suicidés ont utilisé un seul moyen pour se suicider et le suicide complexe (utilisation de plusieurs moyens) a concerné seulement un cas dans notre étude. La pendaison reste le mode le plus utilisé. Conclusion Les hommes préfèrent donc des moyens de suicides violents (pendaison, arme à feu et arme blanche) alors que les femmes et les adolescents (tout sexe confondu) utilisent les intoxications. Le recueil des facteurs concourant au suicide permettrait une prévention de ce dernier. PMID:23847707

  17. W. E. B. Du Bois: A Dynamic Communicator and Cultural Iconoclast.

    ERIC Educational Resources Information Center

    Reppert, James E.

    This paper presents a biographical sketch of the prolific African-American writer and sociologist W.E.B. Du Bois, designed as an instructional unit in an introduction to mass communication course which can help make students aware of the roles played by ethnic minorities in shaping American and world media. The paper provides numerous details of…

  18. College of DuPage District 502 Educational Needs Assessment (Total Sample Summary).

    ERIC Educational Resources Information Center

    Rice, Gary

    In spring 1987, the Gallup Organization conducted a telephone survey for the College of DuPage (COD) in Illinois to determine community perceptions of the college's role in the community; community awareness of COD and its competitors; perceptions of current college services; importance of factors in selecting an educational program; interest in…

  19. Student Profile, College of DuPage, Fall 1986-1989. Topical Paper.

    ERIC Educational Resources Information Center

    Rice, Gary

    Prepared to provide staff with a more comprehensive profile of the student body of the College of DuPage (COD), Illinois, this report looks at changes in the student body and its increasing diversity over the last 5 years, and raises issues for staff discussion and planning. The report is divided into 18 sections, each consisting of an…

  20. Inflectional Morphology in Cri du Chat Syndrome--A Case Study

    ERIC Educational Resources Information Center

    Kristoffersen, Kristian Emil

    2012-01-01

    This study examined morphological skills in a girl with cri du chat syndrome, addressing three questions: (1) To what extent does the subject inflect words? (2) To what extent are words inflected correctly? (3) To what extent do the inflected words reflect productive morphological rules, and to what extent can they be considered to be…

  1. Traitement chirurgical des fractures articulaires du calcanéum par plaque vissée

    PubMed Central

    Hammou, Nassreddine; Abid, Hatim; Shimi, Mohammed; El Ibrahimi, Abdelhalim; El Mrini, Abdelmajid

    2015-01-01

    Les fractures du calcanéum sont peu fréquentes mais le plus souvent graves. Le traitement chirurgical par plaque vissée est ardemment défendu. L'objectif de notre travail rétrospectif est d’évaluer les résultats du traitement chirurgical des fractures articulaires du calcanéum à travers une série de 12 patients opérée aux service d'orthopédie du CHU Hassan II de Fès sur une durée de 3 ans, et les comparer aux données de la littérature. L’âge moyen dans notre série était de 34 ans, le geste opératoire était réalisé au 7ème jour. Tous nos patient ont bénéficie d'une réduction à foyer ouvert avec une ostéosynthèse par plaques vissées. Le recul moyen était de 12 mois et les résultats fonctionnels ont été évaluer selon le score de Kitaoka. PMID:26161214

  2. (Fond du Lac archeological resources within the Draft Area Recommendation Report)

    SciTech Connect

    Danz, D.L.

    1986-07-28

    Research into archaeological resources of the Fond du Lac Band within the DOE proposed high-level nuclear waste sites resulted in the discovery of four traditional ancestral sites. A number of ancestral sites that are located within other proposed repository sites were also discovered.

  3. DuPont extends CFC production after EPA warns of scarcity

    SciTech Connect

    Kirschner, E.

    1994-01-05

    DuPont reversed its voluntary commitment to phase out CFC production at the end of 1994 to prevent a possible shortage for automotive air conditioning repairs. In a December letter, the US EPA asked Dupont to continue producing its full 1995 allowance of 76 million tons of CFC-12 under the Montreal Protocol.

  4. Speech and Language Development in Cri Du Chat Syndrome: A Critical Review

    ERIC Educational Resources Information Center

    Kristoffersen, Kristian Emil

    2008-01-01

    This article reviews research on speech and language abilities in people with cri du chat syndrome (CCS). CCS is a rare genetic disorder, with an estimated incidence between 1 in 15,000 and 1 in 50,000 births, resulting from a deletion on the short arm of chromosome 5. In general, individuals have delayed speech and language development, and some…

  5. Grammatical Constructions in Cri du Chat Syndrome--Findings from a Case Study

    ERIC Educational Resources Information Center

    Kristoffersen, Kristian Emil

    2009-01-01

    The literature on grammatical skills in persons with Cri du chat syndrome (CCS) is very limited, and the need for more knowledge in this area is thus evident, in particular for speech and language therapists working with individuals with this syndrome. This case study report describes the syntactic skills of a 14-year-old Norwegian girl with CCS.…

  6. Des proprietes de l'etat normal du modele de Hubbard bidimensionnel

    NASA Astrophysics Data System (ADS)

    Lemay, Francois

    Depuis leur decouverte, les etudes experimentales ont demontre que les supra-conducteurs a haute temperature ont une phase normale tres etrange. Les proprietes de ces materiaux ne sont pas bien decrites par la theorie du liquide de Fermi. Le modele de Hubbard bidimensionnel, bien qu'il ne soit pas encore resolu, est toujours considere comme un candidat pour expliquer la physique de ces composes. Dans cet ouvrage, nous mettons en evidence plusieurs proprietes electroniques du modele qui sont incompatibles avec l'existence de quasi-particules. Nous montrons notamment que la susceptibilite des electrons libres sur reseau contient des singularites logarithmiques qui influencent de facon determinante les proprietes de la self-energie a basse frequence. Ces singularites sont responsables de la destruction des quasi-particules. En l'absence de fluctuations antiferromagnetiques, elles sont aussi responsables de l'existence d'un petit pseudogap dans le poids spectral au niveau de Fermi. Les proprietes du modele sont egalement etudiees pour une surface de Fermi similaire a celle des supraconducteurs a haute temperature. Un parallele est etabli entre certaines caracteristiques du modele et celles de ces materiaux.

  7. Sleep in Individuals with Cri du Chat Syndrome: A Comparative Study

    ERIC Educational Resources Information Center

    Maas, A. P. H. M.; Didden, R.; Korzilius, H.; Braam, W.; Smits, M. G.; Curfs, L. M. G.

    2009-01-01

    Background: Sleep problems are common in individuals with intellectual disability. Little is known about sleep in children and adults with Cri du Chat syndrome (CDC). Method: Sleep was investigated in 30 individuals with CDC using a sleep questionnaire. Sleep problems and sleep behaviours in individuals with CDC were compared with individuals with…

  8. Office Automation Pilot: A Paperless Approach at College of DuPage.

    ERIC Educational Resources Information Center

    Carlson, Bart

    The pilot project described in this report was undertaken by the College of DuPage (CD) to increase the clerical efficiency of seven administrative offices through the installation of a computerized word processing and data transmission system. The first section of the report provides background information detailing: the history of computer…

  9. The Double-Consciousness of Du Bois & the "Mestiza Consciousness" of Anzaldua.

    ERIC Educational Resources Information Center

    Martinez, Theresa A.

    2002-01-01

    Suggests that W.E.B. Du Bois' concept of the "double-consciousness" and Gloria Anzaldua's concept of the "mestiza consciousness" are significant forms of oppositional culture and consciousness. Asserts that their two concepts are linked and nuanced ideas that describe interlocking systems of oppression spanning two centuries and arguably binding…

  10. W.E.B. DuBois's Challenge to Scientific Racism.

    ERIC Educational Resources Information Center

    Taylor, Carol M.

    1981-01-01

    Proposes that a direct and authoritative challenge to the scientific racism of the late eighteenth and early twentieth centuries was urgently needed, and was one of the leading rhetorical contributions of W.E.B. DuBois. Specifically examines three issues: social Darwinism, the eugenics movement, and psychologists' measurement of intelligence.…

  11. Draft Genome Sequences of Kosmotoga sp. Strain DU53 and Kosmotoga arenicorallina S304.

    PubMed

    Pollo, Stephen M J; Charchuk, Rhianna; Nesbø, Camilla L

    2016-01-01

    Here, we announce the draft genome sequences of two thermophilic Thermotogae bacteria: Kosmotoga sp. strain DU53, isolated from a continental oil reservoir, and Kosmotoga arenicorallina, isolated from hydrothermal sediments. The sequences will provide further insight into evolution of the Kosmotogales. PMID:27313308

  12. College of DuPage Information Technology Plan, Fiscal Year 1994-95.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL.

    Building upon four previous planning documents for computing at College of DuPage in Illinois, this plan for fiscal year 1995 (FY95) provides a starting point for future plans to address all activities that relate to the use of information technology on campus. The FY95 "Information Technology Plan" is divided into six sections, each providing an…

  13. KHAN DU! II. Final Project Performance Report, November 1, 1978-September 30, 1979.

    ERIC Educational Resources Information Center

    KLRN/KLRU-TV, Austin, TX.

    This KHAN DU! project produced four half-hour television programs in the area of career education with emphasis on the handicapped, plus an extra nonbroadcast program designed for teachers. The four-program series was designed for children aged eight to eleven, although older children have responded favorably. The goals of the series were (1) to…

  14. 75 FR 52938 - E. I. du Pont de Nemours and Company; Notice of Filing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-30

    ... Energy Regulatory Commission E. I. du Pont de Nemours and Company; Notice of Filing August 20, 2010. Take... encourages electronic submission of protests and interventions in lieu of paper using the ``eFiling'' link at...., Washington, DC 20426. This filing is accessible on-line at http://www.ferc.gov , using the ``eLibrary''...

  15. 76 FR 78968 - Environmental Impact Statement: Cook and DuPage Counties, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-20

    ... Federal Highway Administration Federal Aviation Administration Environmental Impact Statement: Cook and Du... (FAA), DOT. ACTION: Revised Notice of Intent to Prepare an Environmental Impact Statement. SUMMARY: The FHWA and FAA are issuing this notice to advise the public that a Tier Two Environmental...

  16. FULL-SCALE DEMONSTRATION OF INDUSTRIAL WASTEWATER TREATMENT UTILIZING DU PONT'S PACT (TRADE NAME) PROCESS

    EPA Science Inventory

    Operating and cost data on startup and the initial 30 months of operation of a 150,000 cu m/day (40-MGD) industrial wastewater treatment plant using Du Pont's PACT process are reported. The process effectively provides secondary/tertiary treatment by adding powdered activated car...

  17. Valeria Fike: College of DuPage Library, Glen Ellyn, IL

    ERIC Educational Resources Information Center

    Berry, John N., III

    2006-01-01

    In this article, the author profiles Valeria Fike, supervisor of reference support and College and Career Information Center services at the College of DuPage Library (CODL), Glen Ellyn, Illinois. Valeria Fike, who supervises some 21 paraprofessionals at CODL, modestly attributes her successful career there to her being "simply in the right place…

  18. Deux espèces nouvelles de puces (Siphonaptera : Ctenophthalmidae & Rhopalopsyllidae) du Chili

    PubMed Central

    Beaucournu, J.-C.; Moreno, L.; González-Acuña, D.

    2011-01-01

    Agastopsylla guzmani n. sp. (Ctenophthalmidae) et Delostichus degus n. sp. (Rhopalopsyllidae) sont décrites. Une clé est donnée pour le genre Agastopsylla ; pour le genre Delostichus, une brève comparaison est faite avec D. incisus et D. ojedoi décrites depuis la parution du Catalogue de Smit en 1987. PMID:21894265

  19. Perceptions of the Impacts of the "Arts du Cirque" Program: A Case Study

    ERIC Educational Resources Information Center

    Deslandes, Rollande; Rivard, Marie-Claude; Joyal, France; Trudeau, Francois

    2010-01-01

    This qualitative study used focus groups to identify the knowledge about the "Arts du Cirque" Program implemented in a primary school and to explore perceptions of its impacts. Data are based on the discourse of school staff members, parents and other members of the community of an elementary school. The impacts on students are illustrated in…

  20. College of DuPage Institutional Plan for Computing, FY93-FY95. Executive Summary.

    ERIC Educational Resources Information Center

    College of DuPage, Glen Ellyn, IL.

    The College of DuPage's 5-year plan for meeting its academic, administrative, and central computing needs is presented. An executive summary reviews the planning process and highlights recommendations and financial considerations. As the first section of the report, the introduction presents the college's demographics, mission and vision…

  1. Restructuring dynamics of DU 145 and LNCaP prostate cancer spheroids.

    PubMed

    Song, Hong; Jain, Shamik K; Enmon, Richard M; O'Connor, Kim C

    2004-01-01

    Neoplastic cells acquire multidrug resistance as they assemble into multicellular spheroids. Image analysis and Monte Carlo simulation provided an insight into the adhesion and motility events during spheroid restructuring in liquid-overlay culture of DU 145 and LNCaP human prostate cancer cells. Irregularly shaped, two-dimensional aggregates restructured through incremental cell movements into three-dimensional spheroids. Of the two cultures examined, restructuring was more pronounced for DU 145 aggregates. Motile DU 145 cells formed spheroids with a minimum cell overlay of 30% for 25-mers as estimated by simulation versus 5% for adhesive LNCaP cells in aggregates of the same size. Over 72 h, the texture ratio increased from 0.55 +/- 0.05 for DU 145 aggregates with projected areas exceeding 2000 microm2 to a value approaching 0.75 +/- 0.02 (P < 0.05). For LNCaP aggregates of comparable size, the increase in texture ratio was more modest, less than 15% during the same time period (P < 0.05). Combined, these data suggest that motility events govern the overall rate of spheroid restructuring. This information has application to the chemosensitization of solid tumors and kinetic modeling of spheroid production. PMID:15723561

  2. Of Faith and Fiction: Teaching W. E. B. Du Bois and Religion

    ERIC Educational Resources Information Center

    Sinitiere, Phillip Luke

    2012-01-01

    W. E. B. Du Bois (1868-1963) is widely known as a champion for the political rights of African Americans, founder of the National Association for the Advancement of Colored People (NAACP), aggressive advocate of Pan-Africanism, staunch supporter of female suffrage, and one of the creative forces behind the Harlem Renaissance. Further still, Du…

  3. Developing a Computer Literate Faculty at College of DuPage.

    ERIC Educational Resources Information Center

    Carlson, Bart

    Until 1978, academic and administrative departments at College of DuPage, an Illinois community college, bought computer related equipment and software without an overall plan or coordination. The development of a coordination plan focused on finding an internal mechanism to solve two problems: individual departments buying computer-related…

  4. Draft Genome Sequences of Kosmotoga sp. Strain DU53 and Kosmotoga arenicorallina S304

    PubMed Central

    Pollo, Stephen M. J.; Charchuk, Rhianna

    2016-01-01

    Here, we announce the draft genome sequences of two thermophilic Thermotogae bacteria: Kosmotoga sp. strain DU53, isolated from a continental oil reservoir, and Kosmotoga arenicorallina, isolated from hydrothermal sediments. The sequences will provide further insight into evolution of the Kosmotogales. PMID:27313308

  5. 77 FR 2774 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement: Fond du Lac...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-19

    ...The FHWA is issuing this notice to advise the public that a limited scope Supplemental Environmental Impact Statement (SEIS) will be prepared for the proposed capacity improvements to Wisconsin Highway 23 from U.S. Highway 151 to County Highway P in Fond du Lac and Sheboygan Counties,...

  6. Etude des facteurs de risque du retard de croissance intra-utérin à Lubumbashi

    PubMed Central

    Moyambe, Jules Ngwe Thaba; Bernard, Pierre; Khang'Mate, Faustin; Nkoy, Albert Mwembo Tambwe A; Mukalenge, Faustin Chenge; Makanda, Daudet; Twite, Eugene; Ndudula, Arthur Munkana; Lubamba, Cham; Kadingi, Arnauld Kabulu; Kayomb, Mutach; Kayamba, Prosper Kalenga Muenze

    2013-01-01

    Introduction Dans notre milieu, il n'existe aucune politique de prévention du Retard de Croissance Intra-Utérin (RCIU) clairement défini. L'objectif de ce travail était d'identifier les facteurs de risque de RCIU afin de proposer une stratégie de lutte contre cette pathologie en agissant surtout sur des facteurs pouvant faire l'objet d'une action préventive. Méthodes Une étude cas-témoins a été menée dans 11 centres hospitaliers de Lubumbashi en République Démocratique du Congo, de Janvier 2010 à Juin 2011, dans le but d'identifier les facteurs de risque du retard de croissance intra-utérin (RCIU). Au total 420 gestantes (cas et témoins) avec grossesse monofoetale d'au moins 24 semaines d'aménorrhée ont été inclues dans l'étude. Les cas correspondaient aux gestantes dont le poids du fœtus était resté inférieur au 10 eme percentile des courbes de référence d'Alexander, après 2 échographies successives réalisées à intervalle de 4 semaines. Les témoins correspondaient aux gestantes dont le poids du fœtus était supérieur ou égal au 10 eme percentile de mêmes courbes. A chaque cas a été apparié un témoin de même parité porteur d'une grossesse de même âge. Résultats L'analyse univariée a identifié comme facteurs de risque: la taille maternelle. Conclusion L'amélioration du niveau socio-économique des populations, la lutte contre le paludisme et les consultations prénatales mieux organisées couplées à une meilleure éducation sanitaire et nutritionnelle peuvent contribuer sensiblement à la réduction de la fréquence du RCIU à Lubumbashi. PMID:23504392

  7. Partial purification and characterization of bacteriocin produced by Enterococcus faecalis DU10 and its probiotic attributes.

    PubMed

    Perumal, Venkatesh; Repally, Ayyanna; Dasari, Ankaiah; Venkatesan, Arul

    2016-10-01

    A novel bacteriocin produced by avian duck isolated lactic acid bacterium Enterococcus faecalis DU10 was isolated. This bacteriocin showed a broad spectrum of antibacterial activity against important food-borne pathogens and was purified by size exclusion chromatography followed by reverse-phase high-performance liquid chromatography in a C-18 column. Tricine-SDS PAGE revealed the presence of a band with an estimated molecular mass of 6.3 kDa. The zymogram clearly linked the antimicrobial activity with this band. This result was further confirmed by mass-assisted laser desorption ionization time-of-flight mass spectrometry, since a sharp peak corresponding to 6.313 kDa was detected and the functional groups were revealed by Fourier transform infrared spectroscopy. Bacteriocin DU10 activity was found sensitive to proteinase-K and pepsin and partially affected by trypsin and α-chymotrypsin. The activity of bacteriocin DU10 was partially resistant to heat treatments ranging from 30 to 90°C for 30 min. It also withstood a treatment at 121°C for 10 min. Cytotoxicity of bacteriocin DU10 by methyl-thiazolyl-diphenyl-tetrazolium bromide assay showed that the viability of HT-29 and HeLa cells decreased 60 ± 0.7% and 43 ± 4.8%, respectively, in the presence of 3,200 AU/mL of bacteriocin. The strain withstood 0.3% w/v of bile oxgall and pH 2 affected the bacterial growth between 2 and 4 hr of incubation. Adhesion properties examined with HT-29 cell line showed 69.85% initial population of strain E. faecalis DU10, which was found to be strongly adhered to this cell line. These results conclude bacteriocin DU10 may be used as a potential biopreservative and E. faecalis DU10 may be used as a potential probiont to control Salmonella infections. PMID:26786752

  8. Mesure de haute resolution de la fonction de distribution radiale du silicium amorphe pur

    NASA Astrophysics Data System (ADS)

    Laaziri, Khalid

    1999-11-01

    Cette these porte sur l'etude de la structure du silicium amorphe prepare par irradiation ionique. Elle presente des mesures de diffraction de rayons X sur de la poudre de silicium cristallin, du silicium amorphe relaxe et non relaxe, ainsi que tous les developpements mathematiques et physiques necessaires pour extraire la fonction de distribution radiale correspondant a chaque echantillon. Au Chapitre I, nous presentons une methode de fabrication de membranes minces de silicium amorphe pur. Il y a deux etapes majeures lors du processus de fabrication: l'implantation ionique, afin de creer une couche amorphe de plusieurs microns et l'attaque chimique, pour enlever le reste du materiau cristallin. Nous avons caracterise premierement les membranes de silicium amorphe par spectroscopie Raman pour verifier qu'il ne reste plus de trace de materiau cristallin dans les films amorphes. Une deuxieme caracterisation par detection de recul elastique (ERD-TOF) sur ces memes membranes a montre qu'il y a moins de 0.1% atomique de contaminants tels que l'oxygene, le carbone, et l'hydrogene. Au Chapitre II, nous proposons une nouvelle methode de correction de la contribution inelastique "Compton" des spectres de diffusion totale afin d'extraire les pics de diffusion elastique, responsable de la diffraction de Bragg. L'article presente tout d'abord une description simplifiee d'une theorie sur la diffusion inelastique dite "Impulse Approximation" (IA) qui permet de calculer des profils de Compton en fonction de l'energie et de l'angle de diffusion 2theta. Ces profils sont utilises comme fonction de lissage de la diffusion Compton experimentale. Pour lisser les pics de diffusion elastique, nous avons utilise une fonction pic de nature asymetrique. Aux Chapitre III, nous exposons de maniere detaillee les resultats des experiences de diffraction de rayons X sur les membranes de silicium amorphe et la poudre de silicium cristallin que nous avons preparees. Nous abordons aussi les

  9. Spectroscopic and calorimetric investigation of short and intermediate-range structures and energetics of amorphous SiCO, SiCN, and SiBCN polymer-derived ceramics

    NASA Astrophysics Data System (ADS)

    Widgeon, Scarlett J.

    Polymer-derived ceramics (PDCs) are a new class of amorphous ceramics in the Si-B-C-N system that are synthesized by the pyrolysis of silicon-based organic polymers. PDCs are lightweight and are resistant to creep, crystallization, and oxidation at temperatures near 1800 K making them ideal for a variety of high temperature applications. In spite of being X-ray amorphous, these materials display structural heterogeneity at the nanometer length scale. Their structure and resulting properties can be drastically altered by the utilization of preceramic polymers with differing chemistry and architectures. Fundamental understanding of the atomic structure is critical in deciphering the structure-property relationships and ultimately in controlling their properties for specific engineering applications. The short-range atomic structure has been extensively investigated using a variety of techniques, however, the structures at length scales beyond next-nearest neighbors remained highly controversial. Here we report the results of a spectroscopic and calorimetric study of short and intermediate -range structure and energetic of SiOC and SiBCN PDCs derived from a wide variety of precursors. SiOC PDCs with different carbon contents were synthesized from polysiloxane precurors and their structures were studied using high-resolution 13C and 29Si nuclear magnetic resonance (NMR) spectroscopy. The results suggest that these PDCs consists of a continuous mass fractal backbone of corner-shared SiC xO4-x tetrahedral units with "voids" occupied by sp 2-hybridized graphitic carbon. The oxygen-rich SiCxO 4-x units are located at the interior of this backbone with a mass fractal dimension of ~ 2.5, while the carbon-rich units occupy the two-dimensional interface between the backbone and the free carbon nanodomains. Such fractal topology is expected to give rise to unusual mechanical and transport properties characteristic of fractal percolation networks. For example, elastic moduli and

  10. Cancer du sein de l'homme: à propos de 6 cas

    PubMed Central

    Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah; Hassani, Karim Ibn Majdoub; Laalim, Said Ait; Anoun, Hicham; Toughrai, Imane; Mazaz, Khalid

    2013-01-01

    Le but de ce travail était d'analyser les caractéristiques cliniques, histologiques, thérapeutiques et pronostiques du cancer du sein chez l'homme. Il s'agissait d'une étude rétrospective portant sur six patients colligés au service de gynécologie obstétrique II, CHU Hassan II durant la période 2009-2012. L’âge moyen de nos patients est de 65.3 ans. Il s'agit dans 83.3% des cas, d'une tumeur rétroaréolaire dont la taille moyenne est de 44.16 mm. Nous avons retrouvé 4 (66.7%) T4, 1 (16.7%) T3 et dans un cas, une tumeur inclassable. Le type histologique le plus représenté est le carcinome canalaire infiltrant (66.7%). Le taux d'envahissement ganglionnaire axillaire est de 66.7%. L'hormonodépendance de ces tumeurs est prouvée dans 100% des cas. La survie à cinq ans est en cours d’évaluation. L'envahissement ganglionnaire, l'invasion du derme, le stade clinique TNM sont des facteurs qui influencent significativement la survenue de métastases. Aucun de ces facteurs de risque n'est apparu significatif en termes de survie globale. Le cancer du sein chez l'homme est une maladie rare (environ 1% des cancers du sein) au pronostic sombre. Le diagnostic est le plus souvent tardif et les lésions sont traitées à des stades avancés. PMID:24711870

  11. DuPont/HFM Forum on Carpet in Health Care Facilities. Second in a series. Roundtable discussion.

    PubMed

    1993-12-01

    DuPont and Health Facilities Management magazine invited 20 national expert to Dalton, GA--the carpet-manufacturing capital of the world--on May 13 to take part in DuPont's first-ever Forum on Carpet in Health Care Facilities. During the two-hour roundtable discussion, moderated by DuPont's Jack Murph and HFM's Michael Hemmes, end-users, interior designers and carpet mill representatives talked about the aesthetic, economic and performance aspects of using carpet in health care settings. Here's an edited version of what they said. PMID:10183994

  12. Characterization of DuPont 9015, aqueous processable dry film photoresist for printed wiring boards. Topical report

    SciTech Connect

    Goldammer, S.

    1995-04-01

    This report describes the evaluation of DuPont`s Riston 9015, fully aqueous processable dry film photoresist as a mask for gold plating, tin/lead plating, and print and etch patterning for printed circuit board products.

  13. Technology Demonstration Summary. DuPont/Oberlin Microfiltration System. Palmerton, Pennsylvania (EPA/540/S5-90/007)

    EPA Science Inventory

    In April and May 1990, the U.S. Environmental Protection Agency (EPA), under the Superfund Innovative Technology Evaluation (SITE) program, demonstrated DuPont/Oberlin's microfiltration system at the Palmerton Zinc Superfund (PZS) site In Palmerton, Pennsylvania. The microfiltr...

  14. Acceptabilité du test VIH proposé aux nourrissons dans les services pédiatriques, en Côte d'Ivoire, Significations pour la couverture du diagnostic pédiatrique

    PubMed Central

    Oga, Maxime; Brou, Hermann; Dago-Akribi, Hortense; Coffie, Patrick; Amani-Bossé, Clarisse; Ékouévi, Didier; Yapo, Vincent; Menan, Hervé; Ndondoki, Camille; Timité-Konan, M.; Leroy, Valériane

    2014-01-01

    Résumé Problème: Le dépistage VIH chez les enfants a rarement été au centre des préoccupations des chercheurs. Quand le dépistage pédiatrique a retenu l'attention, cela a été pour éclairer seulement sur les performances diagnostiques en ignorant même que le test pédiatrique comme bien d'autres peut s'accepter ou se refuser. Cet article met au cœur de son analyse les raisons qui peuvent expliquer qu'on accepte ou qu'on refuse de faire dépister son enfant. Objectif: Etudier chez les parents, les mères, les facteurs explicatifs de l'acceptabilité du test VIH des nourrissons de moins de six mois. Méthodes: Entretien semi-directif à passages répétés avec les parents de nourrissons de moins de six mois dans les formations sanitaires pour la pesée/vaccination et les consultations pédiatriques avec proposition systématique d'un test VIH pour leur nourrisson. Résultats: Nous retenons que la réalisation effective du test pédiatrique du VIH chez le nourrisson repose sur trois éléments. Primo, le personnel de santé par son discours (qui dénote de ses connaissances et perceptions même sur l'infection) orienté vers les mères influence leur acceptation ou non du test. Secundo, la mère qui par ses connaissances et perceptions même sur le VIH, dont le statut particulier, l'impression de bien-être chez elle et son enfant influence toute réalisation du test pédiatrique VIH. Tertio, l'environnement conjugal de la mère, particulièrement caractérisé par les rapports au sein du couple, sur la facilité de parler du test VIH et sa réalisation chez les deux parents ou chez la mère seulement sont autant de facteurs qui influencent la réalisation effective du dépistage du VIH chez l'enfant. Le principe préventif du VIH, et le désir de faire tester l'enfant ne suffisent pas à eux seuls pour aboutir à sa réalisation effective, selon certaines mères confrontées au refus du conjoint. A l'opposé, les autres mères refusant la r

  15. World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek

    USGS Publications Warehouse

    Labay, Keith A.; Wilson, Frederic H.

    2004-01-01

    The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

  16. Eucommia bark (Du-Zhong) improves diabetic nephropathy without altering blood glucose in type 1-like diabetic rats

    PubMed Central

    Niu, Ho-Shan; Liu, I-Min; Niu, Chiang-Shan; Ku, Po-Ming; Hsu, Chao-Tien; Cheng, Juei-Tang

    2016-01-01

    Background Eucommia bark, Eucommia ulmoides Oliver barks (Du-Zhong in Mandarin), is an herb used for renal dysfunction in Chinese traditional medicine. In an attempt to develop this herb as a treatment for diabetic nephropathy (DN), we investigated the effects of Du-Zhong on renal dysfunction in type 1-like diabetic rats. Methods Streptozotocin (STZ) was used to induce type 1-like diabetes in rats (STZ-diabetic rats). In addition to hyperglycemia, STZ-diabetic rats showed significant nephropathy, including higher plasma levels of blood urea nitrogen, creatinine, and renal fibrosis. Western blot analysis of renal cortical tissue was applied to characterize the changes in potential signals related to nephropathy. Results Oral administration of Du-Zhong (1 g/kg/day) to STZ-diabetic rats for 20 days not only decreased the plasma levels of blood urea nitrogen and creatinine but also improved renal fibrosis, whereas the plasma glucose level was not changed. The higher expressions of protein levels of transforming growth factor-beta (TGF-β) and connective tissue growth factor in diabetic rats were markedly attenuated by Du-Zhong. The increased phosphorylation of Smad2/3 in STZ-diabetic rats was also reduced by Du-Zhong. However, Du-Zhong cannot reverse the hyperglycemia-induced overproduction of signal transducers and activators of transcription 3 in the diabetic kidney. Conclusion Oral administration of Du-Zhong improves STZ-induced DN in rats by inhibiting TGF-β/Smad signaling and suppressing TGF-β/connective tissue growth factor expression. Therefore, active principle from Du-Zhong is suitable to develop as new agent for DN in the future. PMID:27041999

  17. W. E. B. Du Bois: Crusader for Peace. With a Message from Benjamin L. Hooks. Picture-Book Biography Series.

    ERIC Educational Resources Information Center

    Cryan-Hicks, Kathryn T.

    A biogaphy of W. E. B. Du Bois is presented in this book for young children. Du Bois is widely regarded as the foremost black intellectual from the United States. A great scholar, he was the first black American to receive a Ph.D. from Harvard University. Of his written work he is probably best known for his essays, "The Souls of Black Folk." Du…

  18. Etude échographique du diamètre de l'enveloppe du nerf optique chez l'enfant noir africain sain

    PubMed Central

    de Tové, Kofi-Mensa Savi; Biaou, Olivier; Adedemy, Julien Didier; Fatigba, Olatoundji Holden; Yèkpè, Patricia; Boco, Vicentia; Agossou-Voyeme, Augustin Karl

    2014-01-01

    Introduction L'objectif de cette étude était de déterminer le diamètre échographique de l'enveloppe du nerf optique (DENO) dans une population d'enfants sains noirs Africains au Bénin. Méthodes Une étude transversale descriptive a été menée sur une période de 6mois. Le DENO a été mesuré chez 304 enfants sains. Deux mesures échographiques du DENO (coupe transversale et sagittale) ont été réalisées 3mm en arrière de la papille sur chaque œil. Le DENO d'un patient est égal à la moyenne des quatre mesures. Résultats L’âge moyen était de 35, 72 ± 35,38 mois et la sex-ratio H/F de 0,96. La mesure moyenne du DENO était de 3, 31±0,54mm avec des extrêmes de 2,02 et de 4,44mm. Le DENO croît avec l’âge avec une moyenne corrélation significative (r = 0,58 et p < 0,0001). Cette croissance est plus marquée pendant les 48 premiers mois de vie. Il n'y avait pas de différence entre les garçons et les filles (p = 0, 45). Conclusion Les valeurs retrouvées dans cette étude ne diffèrent pas de ce qui est classiquement décrit dans les autres populations. Un DENO supérieur à 4,40 (IC 95%) doit être considéré comme anormal. PMID:25870740

  19. Nouvelles approches en theorie du champ moyen dynamique: le cas du pouvoir thermoelectrique et celui de l'effet orbital d'un champ magnetique

    NASA Astrophysics Data System (ADS)

    Arsenault, Louis-Francois

    Les applications reliees a la generation d'energie motivent la recherche de materiaux ayant un fort pouvoir thermoelectrique (S). De plus, S nous renseigne sur certaines proprietes fondamentales des materiaux, comme, par exemple, la transition entre l'etat coherent et incoherent des quasi-particules lorsque la temperature augmente. Empiriquement, la presence de fortes interactions electron-electron peut mener a un pouvoir thermoelectrique geant. Nous avons donc etudie le modele le plus simple qui tient compte de ces fortes interactions, le modele de Hubbard. La theorie du champ moyen dynamique (DMFT) est tout indiquee dans ce cas. Nous nous sommes concentres sur un systeme tridimensionnel (3d) cubique a face centree (fcc), et ce, pour plusieurs raisons. A) Ce type de cristal est tres commun dans la nature. B) La DMFT donne de tres bons resultats en 3d et donc ce choix sert aussi de preuve de principe de la methode. C) Finalement, a cause de la frustration electronique intrinseque au fcc, celui-ci ne presente pas de symetrie particule-trou, ce qui est tres favorable a l'apparition d'une grande valeur de S. Ce travail demontre que lorsque le materiau est un isolant a demi-remplissage a cause des fortes interactions (isolant de Mott), il est possible d'obtenir de grands pouvoirs thermoelectriques en le dopant legerement. C'est un resultat pratique important. Du point de vue methodologique, nous avons montre comment la limite de frequence infinie de S et l'approche dite de Kelvin, qui considere la limite de frequence nulle avant la limite thermodynamique pour S, donnent des estimations fiables de la vraie limite continue (DC) dans les domaines de temperature appropriee. Ces deux approches facilitent grandement les calculs en court-circuit ant la necessite de recourir a de problematiques prolongements analytiques. Nous avons trouve que la methode de calcul a frequence infinie fonctionne bien lorsque les echelles d'energie sont relativement faibles. En d'autres termes

  20. Steroid sulfatase inhibitor DU-14 protects spatial memory and synaptic plasticity from disruption by amyloid β protein in male rats.

    PubMed

    Yue, Xing-Hua; Tong, Jia-Qing; Wang, Zhao-Jun; Zhang, Jun; Liu, Xu; Liu, Xiao-Jie; Cai, Hong-Yan; Qi, Jin-Shun

    2016-07-01

    Alzheimer's disease (AD) is an age-related mental disorder characterized by progressive loss of memory and multiple cognitive impairments. The overproduction and aggregation of Amyloid β protein (Aβ) in the brain, especially in the hippocampus, are closely involved in the memory loss in the patients with AD. Accumulating evidence indicates that the Aβ-induced imbalance of dehydroepiandrosterone (DHEA) and dehydroepiandrosterone sulfate (DHEAS) in the brain plays an important role in the AD pathogenesis and progression. The level of DHEA is elevated, while DHEAS is dramatically decreased in the AD brain. The present study tried to restore the balance between DHEA and DHEAS by using a non-steroidal sulfatase inhibitor DU-14, which increases endogenous DHEAS through preventing DHEAS converted back into DHEA. We found that: (1) DU-14 effectively attenuated the Aβ1-42-induced cognitive deficits in spatial learning and memory of rats in Morris water maze test; (2) DU-14 prevented Aβ1-42-induced decrease in the cholinergic theta rhythm of hippocampal local field potential (LFP) in the CA1 region; (3) DU-14 protected hippocampal synaptic plasticity against Aβ1-42-induced suppression of long term potentiation (LTP). These results provide evidence for the neuroprotective action of DU-14 against neurotoxic Aβ, suggesting that up-regulation of endogenous DHEAS by DU-14 could be beneficial to the alleviation of Aβ-induced impairments in spatial memory and synaptic plasticity. PMID:27222435

  1. Active Interrogation Observables for Enrichment Determination of DU Shielded HEU Metal Assemblies with Limited Geometrical Information

    SciTech Connect

    Pena, Kirsten E; McConchie, Seth M; Crye, Jason Michael; Mihalczo, John T

    2011-01-01

    Determining the enrichment of highly enriched uranium (HEU) metal assemblies shielded by depleted uranium (DU) proves a unique challenge to currently employed measurement techniques. Efforts to match time-correlated neutron distributions obtained through active interrogation to Monte Carlo simulations of the assemblies have shown promising results, given that the exact geometries of both the HEU metal assemblies and DU shields are known from imaging and fission site mapping. In certain situations, however, it is desirable to obtain enrichment with limited or no geometrical information of the assemblies being measured. This paper explores the possibility that the utilization of observables in the interrogation of assemblies by time-tagged D-T neutrons, including time-correlated distribution of neutrons and gammas using liquid scintillators operating on the fission chain time scale, can lead to enrichment determination without a complete set of geometrical information.

  2. VizieR Online Data Catalog: Cordoba Carte du Ciel-Astrographic Catalog, CCAC (Orellana+, 2010)

    NASA Astrophysics Data System (ADS)

    Orellana, R. B.; de Biasi, M. S.; Bustos Fierro, I. H.; Calderon, J. H.

    2010-07-01

    This is Cordoba Carte du Ciel-Astrographic Catalog (CCAC) constructed from four Carte du Ciel and one Astrographic Catalog photographic plates for first epoch positions in the region of the open cluster Collinder 132. The plates were digitized using the MAMA measuring machine from the Paris Observatory. Stars from Tycho-2 catalogue (Hog et al., 2000, Cat. I/259) were used as reference stars. Every plate was reduced independently from the others adopting a first order polynomial in the measured coordinates. Proper motions were calculated using the CCAC positions as first epoch, and as second epoch the positions given by UCAC2 (Zacharias et al., 2004, Cat. I/289) and USNO-B1.0 (Monet et al., 2003, Cat. I/284). (2 data files).

  3. Limb shape observations at the Pic du Midi Observatory. Determination of the solar gravitational moments

    NASA Astrophysics Data System (ADS)

    Rozelot, J. P.; Lefebvre, S.

    The accurate shape of the Sun has been actively debated since 1974. So far, balloon and satellite experiments achieved the required sensibility to measure the expected small asphericities of the solar limb shape. However, exceptional good meteorological conditions encountered during several missions at the Pic du Midi Observatory have permitted to measure the coefficients shape of the solar limb on the two first Legendre polynomials expansion. In theory, this photospheric outer shape is sensitive to the interior rate, and asphericities can be explained both in terms of gravitational moments and thermal wind. We present observations made at the Pic du Midi Observatory and we compare results with these obtained by SDS (Sofia et al., 1994, 1996) and SOHO/MDI (Kuhn, 1999). The accepted and dedicated PICARD space mission on this subject is briefly presented.

  4. Watershed Data Management (WDM) Database for Salt Creek Streamflow Simulation, DuPage County, Illinois

    USGS Publications Warehouse

    Murphy, Elizabeth A.; Ishii, Audrey

    2006-01-01

    The U.S. Geological Survey (USGS), in cooperation with DuPage County Department of Engineering, Stormwater Management Division, maintains a database of hourly meteorologic and hydrologic data for use in a near real-time streamflow simulation system, which assists in the management and operation of reservoirs and other flood-control structures in the Salt Creek watershed in DuPage County, Illinois. The majority of the precipitation data are collected from a tipping-bucket rain-gage network located in and near DuPage County. The other meteorologic data (wind speed, solar radiation, air temperature, and dewpoint temperature) are collected at Argonne National Laboratory in Argonne, Illinois. Potential evapotranspiration is computed from the meteorologic data. The hydrologic data (discharge and stage) are collected at USGS streamflow-gaging stations in DuPage County. These data are stored in a Watershed Data Management (WDM) database. This report describes a version of the WDM database that was quality-assured and quality-controlled annually to ensure the datasets were complete and accurate. This version of the WDM database contains data from January 1, 1997, through September 30, 2004, and is named SEP04.WDM. This report provides a record of time periods of poor data for each precipitation dataset and describes methods used to estimate the data for the periods when data were missing, flawed, or snowfall-affected. The precipitation dataset data-filling process was changed in 2001, and both processes are described. The other meteorologic and hydrologic datasets in the database are fully described in the annual U.S. Geological Survey Water Data Report for Illinois and, therefore, are described in less detail than the precipitation datasets in this report.

  5. Malformations vasculaires au cours du syndrome de Williams-Beuren: à propos de trois nouvelles observations

    PubMed Central

    Sator, Hicham; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Rhouni, Fatima Ezzahra; Benjouad, Ibitihale; Dafiri, Rachida; Chat, Latifa

    2016-01-01

    Le syndrome de Williams-Beuren est une maladie génétique rare, il associe classiquement une dysmorphie faciale assez spécifique, des malformations cardiovasculaires et un profil neuropsychologique particulier. Nous rapportons les observations de trois enfants atteints du syndrome de Williams-Beuren en insistant surtout sur les anomalies vasculaires observées sur l'angio-scanner et angio-IRM. PMID:27200143

  6. L'effet des deformations plastiques severes sur les proprietes d'hydruration du magnesium

    NASA Astrophysics Data System (ADS)

    Lang, Julien

    Le travail de recherche effectue durant mon projet de maitrise en physique a l'Universite du Quebec a Trois-Rivieres dans les laboratoires de l'Institut de Recherche sur l'Hydrogene etait de comparer l'effet du laminage a froid de la poudre de MgH2 avec celui du broyage mecanique. Nous avons etudie cette nouvelle technique en utilisant un laminoir vertical concu specialement pour laminer de la poudre. Nous avons lamine la poudre de MgH2 5, 25, 50 et 100 fois. La comparaison de la morphologie de la poudre de MgH 2 telle que recu du manufacturier et broye mecaniquement pendant 30 minutes avec celle de la poudre laminee ete faite a l'aide d'un microscope electronique a balayage. Nous avons par la suite mesure les proprietes de sorption d'hydrogene grace un appareil PCT de type Sievert. Nous avons aussi determine la structure cristalline par diffraction de rayons X. A partir de ces resultats, nous avons constate que le nombre optimal de laminages est de cinq et a les caracteristiques d'absorption/desorption d'hydrogene similaires a un broyage mecanique de 30 minutes. Nous avons aussi utilise les courbes de cinetiques d'absorption et de desorption d'hydrogene pour calculer l'etape limitative dans les reactions de sorption des echantillons lamines. Comme cinq laminages se font en environ 10 secondes, on voit que le laminage a froid est une technique plus interessante industriellement que le broyage mecanique a cause de l'important gain en temps et en energie.

  7. Amateur observations with one meter professional telescope at Pic du Midi

    NASA Astrophysics Data System (ADS)

    Delcroix, M.; Colas, F.; Dauvergne, J.-L.; Lecacheux, J.; Vachier, F.; Pellier, C.

    2014-04-01

    Since its creation, many professional observations of the solar system have been performed from the one meter telescope at professional astronomy observatory at Pic-du-Midi de Bigorre (2877m, France). Since a few years, a few experienced amateur astronomers can use it autonomously to make useful observations and following of solar system bodies, leading to a useful collaboration with professional astronomers on the study of giant planets, which retributes them for their involvement in planetary science.

  8. Décompression chirurgicale du syndrome de défilé thoraco-brachial

    PubMed Central

    Lukulunga, Loubet Unyendje; Moussa, Abdou Kadri; Mahfoud, Mustapha; Ismael, Farid; Berrada, Mohamed Saleh; El Yaacoubi, Moradh

    2014-01-01

    Le syndrome de défilé thoraco-brachial est une pathologie souvent méconnue à cause de diagnostic difficile par manque des signes pathognomoniques conduisant souvent à des errances. Les manifestations cliniques dépendent selon qu'il s'agit d'une compression nerveuse, vasculaire ou vasculo-nerveuse. Le but de cette étude est de décrire certains aspects cliniques particuliers et évaluer le résultat fonctionnel après la décompression chirurgicale du paquet vasculo-nerveux. Notre étude rétrospective a porté sur l'analyse des données cliniques, radiologiques, IRM et EMG sur les patients opérés entre janvier 2010 et juillet 2013 du syndrome de défilé thoraco-brachial dans le service de traumatologie orthopédie de l'hôpital Ibn Sina de Rabat. 15 cas ont été colligés: 12 cas post traumatiques (fracture de la clavicule) et 3 cas d'origines congénitales, dont l’âge moyen était 35 ans (20 à 50 ans) avec 9 femmes et 6 hommes. A la fin du traitement, le score de Dash est passé de 109 (46% Normal=0) à 70 (20%), et le stress test de Roos était de 70/100 à 80/100. Le résultat était excellent dans 12 cas soit (80%) et moins bon dans dans 3 cas (20%). En définitive, la résection de malformations osseuses, l'excision des brides et la neurolyse du plexus brachial suivie de la rééducation a donné une bonne évolution fonctionnelle. PMID:25709735

  9. LA TRANSPLANTATION HÉPATIQUE ORTHOTOPIQUE À L’UNIVERSITÉ DU COLORADO

    PubMed Central

    Corman, J.; Starzl, T. E.

    2010-01-01

    Ce travail a été réalisé grâce aux fonds de recherche de la Veterans Administration, aux fonds RR-00051 et RR-00069 du programme des centres de recherche clinique générale de la Division of Research Resources, National Institutes of Health, et aux fonds AI-10176-01, AI-AM-08898, et AM-07772. PMID:21572894

  10. Du Pont Classification of ASASSN-16jc as a Young SN Ia

    NASA Astrophysics Data System (ADS)

    Shappee, Benjamin J.; Prieto, J. L.; Rich, J.; Seibert, M.; Madore, B.; Poetrodjojo, Henry; D'Agostino, Joshua

    2016-08-01

    We report optical spectroscopy (range 370-910 nm) of ASASSN-16jc discovered by the All-Sky Automated Survey for Supernovae (ASAS-SN; Shappee et al. 2014, ApJ, 788, 48) using the du Pont 2.5-m telescope (+ WFCCD) at Las Campanas Observatory on Aug. 24 2016 UT. We performed a cross-correlation with a library of supernova spectra using the "Supernova Identification" code (SNID; Blondin and Tonry 2007, Ap.J. 666, 1024).

  11. Mesusage du tramadol par les adolescents et jeunes adultes en situation de rue

    PubMed Central

    Maiga, Djibo Douma; Seyni, Houdou; Moussa, Ali Ousmane; Sidikou, Amadou

    2012-01-01

    L’objectif de cette étude transversale et descriptive était de décrire quelques caractéristiques de l’addiction au Tramadol chez les adolescents et jeunes adultes en situation de rue, rattachés aux centres d’écoute du Service Educatif, Judiciaire et préventif (SEJUP) de Niamey. Le recueil des données a porté sur les variables sociodémographiques et la consommation de tramadol. L’analyse des données a calculé les moyennes, minima, maxima et écarts types. Les résultats indiquent que : trois centres d’écoute sur huit participaient à l’étude. L’échantillon constituait 61 adolescents et jeunes adultes dont l’âge moyen était de 17,49 ans. L’analyse indique que 47 adolescents et jeunes adultes de toutes les catégories sociodémographiques (sexe, niveau d’instruction, provenance familiale ; région de provenance ; antécdents médicaux; antécédents judiciaires) étaient usagers du Tramadol. 46 étaient dépendants du Tramadol. La quantité moyenne consommée était de 1455,31 ± 901,4mg. Le mésusage du tramadol par les jeunes en situation de rue est probablement une des conséquences de la vente illicite et libre des médicaments, dont il est urgent de préciser les données médicales et sociales. PMID:23330046

  12. The DuPont Conference: Implications for the Chemical Technology Curriculum

    NASA Astrophysics Data System (ADS)

    Kenkel, John; Rutledge, Sue; Kelter, Paul B.

    1998-05-01

    Southeast Community College (SCC) hosted the first DuPont Conference for Chemical Technology Education at its Lincoln, Nebraska campus October 4-6, 1997. The conference brought together fourteen practicing chemists and chemistry technicians and five college and university faculty members for the express purpose of suggesting new laboratory activities that would help relate the real world of work to the education of chemical laboratory technicians in community colleges. Participants included seven men and seven women from DuPont, Procter & Gamble, Eastman Chemical, Eastman Kodak, Dow Chemical, Air Products and Chemicals, Monsanto, Union Carbide, the Nebraska Agriculture Laboratory, and the University of Nebraska Biological Process Development Facility, Department of Food Science. The conference, sponsored by the E. I. DuPont DeNemours & Company through a grant awarded to SCC in June 1997, was intended to help further the goals of the two major projects underway at SCC, funded by the National Science Foundation's Advanced Technological Education Program. These projects, dubbed "Assignment: Chemical Technology I and II", or ACT-I and ACT-II, are curriculum and materials development projects. The invited scientists had between 2 and 32 years of experience that ranged from bench work to management levels. Many are or have been active on the national scene as members and officers of the American Chemical Society's Division of Chemical Technicians and the ACS Committee on Technician Activities.

  13. Révision du genre Bathiorhamnus Capuron (Rhamnaceae) endémique de Madagascar

    PubMed Central

    CALLMANDER, Martin W.; PHILLIPSON, Peter B.; BUERKI, Sven

    2011-01-01

    Le genre endèmique malgache Bathiorhamnus Capuron (Rhamnaceae) est l’objet d’une rèvision taxonomique. L’étude des caractères morphologiques permet de reconnaître sept espèces. En plus des deux espèces antérieurement reconnues: B. cryptophorus Capuron et B. louvelii (H.Perrier) Capuron, les trois variétés reconnues dans la seconde sont réévaluées et élevées au rang d’espèce: B. dentatus (Capuron) Callm., Phillipson & Buerki, B. macrocarpus (Capuron) Callm., Phillipson & Buerki, B. reticulatus (Capuron) Callm., Phillipson & Buerki. Deux nouvelles espèces sont décrites: B. capuronii Callm., Phillipson & Buerki, des forêts sèches de l’ouest et du nord et B. vohemarensis Callm., Phillipson & Buerki des forêts littorales situées autour de Vohémar au nord-est. Une clé du genre Bathiorhamnus est présentée ainsi qu’une évaluation préliminaire du statut de conservation de chaque espèce. PMID:21866216

  14. Les succédanés du sucre durant la grossesse

    PubMed Central

    Pope, Eliza; Koren, Gideon; Bozzo, Pina

    2014-01-01

    Résumé Question J’ai une patiente enceinte qui consomme souvent des succédanés du sucre et elle m’a demandé si cette pratique continue pouvait nuire à sa grossesse ou à son enfant. Que devrais-je lui répondre et existe-t-il d’autres meilleurs choix durant la grossesse? Réponse Il faudrait faire plus de recherche pour déterminer plus exactement les effets de l’exposition aux succédanés du sucre in utero, mais les données disponibles ne laissent pas présager d’effets indésirables durant la grossesse. Toutefois, il est recommandé de consommer des substituts du sucre en quantités modérées et de se conformer aux doses journalières admissibles établies par les organismes de règlementation.

  15. Diosmin induces genotoxicity and apoptosis in DU145 prostate cancer cell line.

    PubMed

    Lewinska, Anna; Siwak, Justyna; Rzeszutek, Iwona; Wnuk, Maciej

    2015-04-01

    Plant-derived dietary polyphenolic compounds, such as flavonoids, with cancer cell-specific pro-apoptotic activity and chemopreventive potential are thought to be promising anticancer agents. In the present study, we were interested in determining if flavonoid-induced genotoxicity may also provoke cancer cell death. Cyto- and genotoxicity of three selected flavonoid glycosides (naringin, diosmin and hesperidin) in DU145 prostate cancer cell line were investigated. Flavonoid glycosides decreased cancer cell number and proliferative activity in a different manner. Flavonoid glycosides induced oxidative stress: intracellular total ROS and superoxide production were augmented after flavonoid treatment. Flavonoid glycosides stimulated DNA double strand breaks (DSBs) and micronuclei production. Diosmin was found the most potent genotoxic agent in DU145 cells, which, in turn, resulted in its pro-apoptotic activity. The more robust recruitment of 53BP1 was correlated with lower DNA and chromosomal damage after naringin and hesperidin treatment compared with diosmin treatment. Flavonoid glycosides were also found to be DNA hypomethylating agents with an ability to modulate cancer cell epigenome leading to changes in the gene expression patterns. Taken together, diosmin, a dietary flavonoid glycoside, was found active against DU145 cells by promoting genotoxic events and a concomitant apoptotic cell death. Thus, a comprehensive analysis of biological activity of diosmin against cancer cells both in vitro and in vivo deserves further investigation. PMID:25499067

  16. Assessment of low-flow water quality in the Du Page River, Illinois

    USGS Publications Warehouse

    Freeman, W.O.; Schmidt, A.R.; Stamer, J.K.

    1986-01-01

    The relations of several stream processes to concentrations of dissolved oxygen and other constituents during low-flow periods were evaluated for a 70.3-mile reach of the Du Page River in northeastern Illinois, using measured data and computer simulations. Reaeration rates and traveltimes were measured at various flow rates using a steady-state gas-tracer technique. Stream discharge, stage, temperature, and chemical constituent concentrations were measured during two 24-hour periods in July and August 1983. These data were used to describe water quality and to calibrate and verify the QUAL-II one dimensional, steady-state, water quality model. Dissolved oxygen concentrations did not meet the State water quality standards in several subreaches of the Du Page River. Concentrations were consistently below the State minimum dissolved oxygen standard in the downstream 8 miles of the East Branch Du Page River. Model simulations indicate that although ammonia oxidation played a role in the dissolved oxygen depletion, the primary factor was sediment oxygen demand. Other measured chemical constituents that did not comply with the State water quality standards in several subreaches of the river included ammonia, iron, fluoride, and total dissolved solids. (USGS)

  17. Fentes labiopalatines dans la province du Katanga en République Démocratique du Congo: Aspects épidémiologiques, anatomocliniques et thérapeutiques

    PubMed Central

    Sangwa, Cedrick Milindi; Mukuku, Olivier; Tshisuz, Christian; Panda, Jules Mulefu; Kakinga, Mireille; Kitembo, Marius Feruzi; Mutomb, Jean-Felix; Odimba, Bwana Fwamba

    2014-01-01

    Les fentes labiopalatines sont les malformations les plus rencontrées de la sphère orofaciale. L'objectif est de décrire le profil épidémiologique, anatomoclinique et thérapeutique des fentes labiopalatines observées dans la province minière du Katanga au sud-est de la République Démocratique du Congo. Il s'agit d'une étude transversale réalisée dans quatre institutions hospitalières de la province du Katanga dans des districts sanitaires différents (Hôpital Jason Sendwe à Lubumbashi, Hôpital Gécamines Panda à Likasi, Hôpital Gécamines du personnel à Kolwezi, Hôpital General de référence de Kamina) et qui a porté sur 154 cas de fentes labiopalatines enregistrés au cours de la période allant du 1er mai 2010 au 30 septembre 2012. L'âge moyen de consultation était de 11,8 ans et une prédominance masculine (55,2%) était notée. Un pic était noté chez les deux premiers nés de la famille (55,8%). Nous avons enregistré 20,7% des cas de consanguinité dont 54,2% de premier degré. La fréquence des différents types de fentes labiopalatines diminue au fur à mesure que la fente s'étend de la lèvre supérieure au palais en passant par l'alvéole : 72% (labiales), 21,4% (labiopalatines) et 7,7% (palatines). Les variétés unilatérales sont plus fréquentes (76,7%) que les bilatérales (16,1%). Dans les formes unilatérales, le côté gauche est plus concerné (47,1%) par rapport au côté droit (38,6%). L'évaluation de la gravité selon Anastassov montre que 50,6% de nos patients étaient de degré moyen et 16,2% étaient à un degré sévère. Les malformations associées ont été retrouvées dans 5% des cas et elles sont à prédominance squelettique. C'est la technique de Millard qui a été la plus pratiquée (72/130). Les résultats étaient excellents dans 71,5% contre 1,5% de mauvais. Le séjour d'hospitalisation était de 3 jours et le taux de complications post opératoire était de 2,98%. PMID:25328615

  18. Modèle simplifié du comportement hygrothermique d'un chai

    NASA Astrophysics Data System (ADS)

    Battaglia, J.-L.; Jomaa, W.; Gounot, J.

    1996-11-01

    Coupling between heat and moisture is often important for some kind of buildings. It is the case for wine and spirit storehouse for the breeding of wine in cask. Without strong assumptions, the knowledge model is too complex is regard to the formulation and the resolution of the equations. In this work, we develop a simplified model based on a preliminary study of the concerned building. For the resolution, an algorithm, adapted to our configuration, is proposed. Assumptions are proved with respect to experimental measurements of temperature and relative moisture, for two periods of the year. A sensitivity analysis of the model to some parameters is carried out. Finally, an implementation of the model, to estimate the quantity of wine lost by evaporation during one year, is presented. Le couplage entre chaleur et humidité est souvent important dans certains types de bâtiment et ne permet pas de traiter les deux transferts indépendamment l'un de l'autre. C'est le cas des chais où se déroule l'élevage du vin en barriques. Sans hypothèses fortes, la prise en compte du couplage hygrothermique donne alors lieu à une modélisation complexe tant au point de vue de sa formulation que la résolution des équations. Dans ce travail, nous développons un modèle simplifié, basé sur une étude préliminaire du bâtiment considéré. Un algorithme de résolution, adapté à la configuration étudiée, est proposé. Les hypothèses de modélisation sont validées à partir de relevés expérimentaux de température et d'humidité, réalisés sur deux périodes de l'année. Une étude de sensibilité du modèle à certains paramètres est menée. Enfin, une application du modèle, pour l'évaluation de la quantité de vin évaporée sur une année, est présentée.

  19. Facteurs de risque cardiovasculaires au cours du lupus systémique

    PubMed Central

    Harzallah, Amel; Hajji, Mariem; Kaaroud, Hayet; Hamida, Fethi Ben; Abdallah, Taieb Ben

    2015-01-01

    Cette étude a pour objectif d’évaluer la fréquence des facteurs de risque cardiovasculaires au cours du lupus et de préciser leur prévalence. Etude rétrospective portant sur 250 patients ayant un lupus, diagnostiqué selon les critères de l'ACR, hospitalisés entre 1970 et 2013. Les données cliniques et para cliniques ont été recueillies à partir des observations médicales. Il s'agit de 228 femmes et 22 hommes d’âge moyen au diagnostic du lupus de 30, 32 ans (extrêmes: 16-69). La durée moyenne du suivi des patients était de 64 mois (extrêmes: 7 jours- 382mois). Quatre vingt dix patients (36%) étaient hypertendus, 74% avaient une hypercholestérolémie et 22% étaient diabétiques. Pour les autres facteurs de risque cardiovasculaire traditionnels, un âge > 50 ans a été retrouvé dans 40% des cas, le sexe masculin dans 8% des cas, l'obésité dans 76% des cas et le tabagisme dans 11% des cas. Les facteurs de risque surajoutés sont représentés par la présence des anticorps antiphospholipides (47% des cas), la néphropathie lupique (49% des cas), l'insuffisance rénale (42% des cas), la corticothérapie au long cours (74% des cas) et la chronicité de la maladie dans 35% des cas. Les complications cardiovasculaires retrouvées dans notre série étaient: les accidents vasculaires cérébraux (2%) et l'insuffisance coronarienne (5,6%). Devant l'importance du risque cardiovasculaire au cours du lupus, une surveillance rapprochée des facteurs de risque cardio-vasculaires semble primordiale chez les lupiques. PMID:27022427

  20. Cultural Heritage Documentation and Integrated Geomatics Techniques in AN Educational Context: Case Bois-Du (belgium)

    NASA Astrophysics Data System (ADS)

    Stal, C.; Goossens, R.; Carlier, L.; Debie, J.; Haoudy, K.; Nuttens, T.; De Wulf, A.

    2013-07-01

    The Walloon Region in Belgium played a leading role in the world economy and in the industrial sciences and engineering since the 19th century. Several relicts, such as important industrial buildings or sites, are spread over a large area and are still dominating the current landscape. Some of these remnants are preserved as monuments, representing the industrial, cultural and ecological transition of the region during the last two centuries. Since 2012, UNESCO recognized the importance of four of the best preserved 19th and 20th century coal mining sites and classified them as World Heritage ("Major Mining Sites of Wallonia", Le Grand-Hornu, Bois-du- Luc, Le Bois du Cazier and Blegny Mine). The four recognised mining sites together form a strip of about 170 km long, containing important examples of the so-called 'neo classical architecture' from the early periods of the industrial era in continental Europe. Motivated by this recognition and by the huge touristic and educational potential of the sites, a partnership between the Walloon government and Ghent University was organized. In this first stage, the collaboration focuses on the site of Bois-du-Luc in the municipality of La Louvière, containing a large series of dwellings, several equipments built between 1853 and 1923 by the Société des Charbonnages du Bois-du-Luc, workshops and heaps. Consisting of numerous buildings dating back to the period between 1838 and 1923, this site is one of Europe's oldest collieries. The collaboration between the Walloon government and Ghent University - Department of Geography fits in the hands-on training which students in land surveying and geomatics receive during their Bachelor studies. For the students it is very interesting that their practical exercises are not limited to the university campus, but that they are involved in a real measurement campaign. The project consists of a series of intensive land surveying campaigns, resulting in highly detailed and accurate

  1. The W. E. B. DuBois and Booker T. Washington Debate: Effects upon African American Roles in Engineering and Engineering Technology

    ERIC Educational Resources Information Center

    Johnson, Keith V.; Watson, Elwood

    2004-01-01

    The messages of Booker T. Washington and W. E. B. DuBois could not have been more diverse. The philosophical rivalry between Washington and DuBois has deep historical roots. To be on the same side fighting for the same purpose, progress, and uplifting of the Black race, these two Black intellectuals harbored radically divergent views on how to…

  2. Actes du colloque sur le bilinguisme, Universite de Neuchatel, 14/15 Septembre, 1981 (Proceedings of the Colloquium on Bilingualism, University of Neuchatel, September 14-15, 1981).

    ERIC Educational Resources Information Center

    TRANEL, 1982

    1982-01-01

    This issue contains proceedings of a colloquium on linguistics at the University of Neuchatel: (1) "Propositions epistemologiques pour une etude du bilinguisme (Epistemological Propositions for a Study of Bilingualism)," by B. Py; (2) "Comment on di ca? Prolegomenes a une etude de la composante semantique du langage des migrants (How Do You Say…

  3. W.E.B. Du Bois and Filipino/a American Exposure Programs to the Philippines: Race Class Analysis in an Epoch of "Global Apartheid"

    ERIC Educational Resources Information Center

    Viola, Michael Joseph

    2016-01-01

    The article highlights the ongoing relevance of W.E.B. Du Bois for the global analysis of race and class. Engaging scholarly debates that have ensued within the educational subfields of critical race theory (CRT) and (revolutionary) critical pedagogy, the article explores how a deeper engagement with Du Bois's ideas contributes theoretically and…

  4. Evaluation de la tenue du partogramme dans une maternité universitaire

    PubMed Central

    Limam, Manel; Zedini, Chekib; El Ghardallou, Meriem; Mellouli, Menel; Bougmiza, Iheb; Sahli, Jihène; Khairi, Hédi; Mtiraoui, Ali; Ajmi, Thouraya Nabli

    2015-01-01

    Introduction La mortalité maternelle est un problème majeur de santé mondiale. Une grande proportion de ces décès serait évitable par des soins adéquats, une aide à l'accouchement, la disponibilité des soins d'urgence et l'utilisation des outils d'aide à la décision tels que le partogramme. L'objectif était d’évaluer l’écart entre ce qui est censé être fait et ce qui est fait réellement pour les différents paramètres situés dans le partogramme au sein d'une maternité de 3ème niveau et élaborer des recommandations pour la mise en place d'un plan d'action. Méthodes Il s'agit d'une étude descriptive rétrospective par audit clinique, effectuée sur un échantillon de 400 dossiers obstétricaux des parturientes ayant accouchées dans la maternité du CHU Farhat Hached durant l'année 2011. Le référentiel utilisé est celui réalisé par l'Agence Nationale d'Accréditation et d'Evaluation en Santé en l'an 2000, concernant la qualité de la tenue du partogramme. Résultats La majorité des critères d’évaluation portant sur la présentation du partogramme était conforme. Deux critères concernant la variété de la présentation et le rythme cardiaque fœtal étaient non conformes parmi ceux portant sur la surveillance du fœtus. Plusieurs critères en rapport avec la surveillance de la mère étaient non conformes. Aucun des critères portant sur les traitements administrés et les marqueurs d’évènements n'est conforme. Les critères portant sur la naissance et la surveillance immédiate qui étaient non conformes sont: le début des efforts expulsifs, le mode d'accouchement, l’état du périnée, la délivrance et la révision utérine. Conclusion La véritable démarche de l'audit clinique se doit d'aller au-delà du recueil et de l'analyse des données, le but final étant l'amélioration des pratiques. PMID:26516400

  5. Carcinoïde primitif du rein métastasant après 12 ans

    PubMed Central

    Bacha, Dhouha; Lahmar, Ahlem; Gharbi, Lassad; Slama, Sana Ben; Bouraoui, Saadia; Chatti, Samia; Regaya, Sabeh Mzabi

    2016-01-01

    Les carcinoïdes primitifs du rein sont rares avec une centaine de cas rapportés dans la littérature. Sur le plan histologique, il s'agit d'une tumeur bien différenciée dont la morphologie rejoint souvent celle des carcinoïdes dans les autres localisations. Nous rapportons un cas de carcinoïde primitif du rein survenant chez un homme de 41 ans, découvert à la suite de métastases hépatiques. La tumeur était particulière par son architecture tubulo-papillaire, suggérant à tort le diagnostic de carcinome papillaire du rein. Ce diagnostic a été redressé 12 ans après, à la suite de l'apparition d'autres métastases hépatiques, osseuses et pulmonaires. PMID:27217899

  6. Evolution des quasiparticules nodales du cuprate supraconducteur YBa2Cu3Oy en conductivite thermique

    NASA Astrophysics Data System (ADS)

    Rene de Cotret, Samuel

    Ce memoire presente des mesures de conductivite thermique sur les supraconducteurs YBCO et Tl-2201 afin de statuer sur la presence possible d'un point critique quantique (QCP) dans le diagramme de phase de cuprates. Ce point critique quantique serait a l'origine de la reconstruction de la surface de Fermi, d'un large cylindre de trous en de petites poches de trous et d'electrons. La conductivite thermique dans le regime T → 0 permet d'extraire une quantite purement electronique liee aux vitesses de Fermi et du gap, au noeud. Une discontinuite dans cette quantite pourrait signaler la traversee du dopage critique qui reconstruit la surface de Fermi. Plusieurs sondes experimentales distinguent une transition de phase ou un crossover a T* a temperature finie. D'autres sondes mettent en evidence une transition de phase sous l'effet d'un champ magnetique. La presence ou non de cet ordre, a temperature et champ magnetique nul questionne la communaute depuis plusieurs annees. Dans cette etude, nous detectons une variation brusque de kappa0/T a p = 0.18 dans YBCO et a p = 0.20 dans Tl-2201. Ces sauts sont interpretes comme un signe de la transition a temperature nulle et sont en faveur d'un QCP. Le manque de donnees d'un meme materiau a ces dopages ne permet pas de valider hors de tout doute l'existence d'un point critique quantique. Le modele theorique YRZ decrit aussi bien les donnees de conductivite thermique. Des pistes de travaux experimentaux a poursuivre sont proposees pour determiner la presence ou non du QCP de facon franche. Mots-cles : Supraconducteurs, cuprates, conductivite thermique, point critique quantique.

  7. Schwannome cervical du nerf vague: Stratégies diagnostique et thérapeutique

    PubMed Central

    Benmansour, Najib; Elfadl, Yasine; Bennani, Amal; Maaroufi, Mustapha; Chbani, Leila; Amarti, Afaf; Tizniti, Siham; Elalami, Mohamed Noureddine

    2013-01-01

    Les schwannomes cervicaux sont des tumeurs bénignes des nerfs périphériques développées exclusivement à partir des cellules de Schwann. L'atteinte du nerf vague cervical est relativement rare, et les auteurs en rappellent, à partir d'un cas, les signes radiologiques évocateurs ainsi que les caractéristiques histologiques. Le traitement de ces tumeurs est chirurgical. Un patient de 32 ans consultait pour une masse latéro-cervicale supérieure droite isolée, évoluant depuis trois ans. Une imagerie médicale (TDM et IRM) cervicale mettait en évidence une masse vascularisée au temps retardé, refoulant la veine jugulaire interne en dehors et l'axe carotidien en dedans. Un examen cytologique non contributif conduisait à réaliser une exérèse chirurgicale extracapsulaire de la masse par voie de cervicotomie. Il s'agissait d'une tumeur rétro-jugulo-carotidienne développée aux dépens du nerf vague cervical droit. L'analyse histologique concluait à un schwannome. Les suites opératoires étaient simples. Le schwannome du nerf vague est une tumeur bénigne rare, qui doit être évoquée devant toute masse latérocervicale isolée. L'imagerie médicale (TDM et IRM) cervicale préopératoire représente les examens de choix indispensable pour évoquer le diagnostic. Le traitement est chirurgical, afin de confirmer le diagnostic histologique. L'exérèse chirurgical complète extracapsulaire est possible et est le seul garant de la non récidive. PMID:23646212

  8. Physical mapping in the Cri du Chat region on human chromosome 5

    SciTech Connect

    Church, D.M.; Bengtsson, U.; Niebuhr, E.

    1994-09-01

    The Cri du Chat syndrome is a segmental aneusomy associated with deletions in the short arm of human chromosome 5. More specifically, the cytogenetic band 5p15.2 must be deleted in order to manifest the typical phenotypic signs. We have studied several cell lines from individuals who have chromosomal abnormalities within this cytogenetic band but who do not have typical Cri du Chat syndrome. In fact, several individual studied have no discernible features of this syndrome. Using fluorescent in situ hybridization (FISH) analysis and PCR analysis on somatic cell hybrids we have mapped the breakpoints relative to each other within this band. There is a great degree of phenotypic heterogeneity between several of the patients, even those which share common breakpoints. This heterogeneity makes it very difficult to narrow the region of interest to a very small (<1 Mb) region. In order to more thoroughly analyze this region, we have assembled a yeast artificial chromosome (YAC) contig of part of this region. This contig has been analyzed for STS content and covers approximately a 1.5-2.0 Mb region within 5p15.2. In addition, we have constructed a radiation hybrid map of the region. The YACs contained within the minimal contig have been used as hybridization probes to isolate corresponding cosmid clones within the region of interest. These cosmids, in turn, are being utilized to obtain potential exons using exon amplification. Several cosmids within this region have been isolated by STS content and potential exons have been isolated from them. These exons have been used as probes to isolate cDNA clones from the region. It is our hope that isolation of genes throughout the region of interest will allow a better understanding of the etiology of Cri du Chat.

  9. Pneumonie varicelleuse du nouveau-né: à propos ďun cas

    PubMed Central

    Noubiap, Jean Jacques Nzeale; Tene, Ulrich Gaël; Bongoe, Adamo

    2012-01-01

    La varicelle est une maladie contagieuse fréquente chez ľenfant, mais rare chez la femme enceinte. La survenue de varicelle pendant la grossesse peut entrainer des complications périnatales dont la pneumonie varicelleuse du nouveau-né. Cette atteinte pulmonaire est accompagnée ďun taux élevé de décès. Nous rapportons un cas de pneumonie varicelleuse grave chez un nouveau-né qui a été contaminé par le virus de la varicelle par voie transplacentaire. Le tableau clinique associait un syndrome infectieux, une détresse respiratoire sévère avec coma, des râles sous-crépitants diffus aux deux champs pulmonaires, et une éruption cutanée disséminée faite de macules, vésicules, croûtes, évocatrice de la varicelle. La radiographie du thorax montrait un syndrome interstitiel diffus aux deux poumons. Un traitement par ľaciclovir injectable associé à ľoxygénothérapie continue a permis une évolution vers la guérison. La pneumonie varicelleuse du nouveau-né est situation associée à une forte mortalité mais dont le traitement par ľaciclovir injectable peut permettre la guérison. La prophylaxie par administration intraveineuse ďaciclovir ou ďimmunoglobulines polyvalentes chez le nouveau-né permet de diminuer la sévérité et la mortalité de la varicelle périnatale. PMID:23308330

  10. Les ruptures traumatiques du tendon quadricipital: à propos de 3 cas

    PubMed Central

    Benyass, Youssef; Chafry, Bouchaib; Koufagued, Kaldadak; Bouabid, Salim; Chagar, Belkacem

    2015-01-01

    Les ruptures traumatiques du tendon quadricipital sont rares, elles surviennent préférentiellement après 40 ans, suite à un traumatisme indirect chez le sportif (flexion contrariée du genou) ou traumatisme banal chez le sédentaire. La tendinopathie préexistante est fréquente. La rupture est le plus souvent totale et siège au corps du tendon 60% des cas ou décallotement quadricipital au bord supérieur de la rotule (40% des cas). Le diagnostic est essentiellement clinique. Les examens complémentaires (échographie et imagerie par résonance magnétique) sont utiles et appuient le diagnostique, mais sont souvent faussement rassurants hormis la radiographie qui montre une rotule basse. Le traitement essentiellement chirurgical associé à la rééducation fonctionnelle donne des résultats largement meilleurs. Le délai d'intervention est un facteur pronostic très important. Les auteurs rapportent 03cas de rupture de tendon quadricipital. L’âge moyen est de 50ans. Ils ont été traités chirurgicalement et revus régulièrement, avec un recul de 16 mois pour apprécier l’évolution. Les résultats ont été très bons chez 02 cas et bon chez 01 cas. L'amélioration a été très nette selon les critères: marche, douleur et reprise d'activité physique. PMID:26985261

  11. L’identification et traitement du trouble panique avec ou sans agoraphobie

    PubMed Central

    Foldes-Busque, Guillaume; Marchand, André; Landry, Pierre

    2007-01-01

    RÉSUMÉ OBJECTIF Renseigner les médecins de première ligne au sujet de l’identification précoce, du diagnostic et du traitement du trouble panique avec ou sans agoraphobie (TP/A). QUALITÉ DES DONNÉES Les données et recommandations présentées proviennent d’une recension des écrits scientifiques réalisée via les banques de données PsycLIT, PsyINFO et MEDLINE (1985 à 2006) en utilisant les descripteurs panic disorder, psychotherapy, psychosocial treatment, treatment et pharmacotherapy. Les recommandations formulées par les auteurs s’appuient sur des données probantes provenant d’études d’excellente qualité. Les informations concernant le diagnostic et l’évaluation du TP/A proviennent d’études épidémiologiques récentes, de consensus et d’opinions d’experts. PRINCIPAL MESSAGE Le TP/A est un trouble psychiatrique souvent rencontré en médecine de première ligne, mais il est fréquemment sous-diagnostiqué et sous-traité. L’identification précoce de ce trouble demande une attention particulière aux symptômes médicalement inexpliqués et, le cas échéant, le médecin doit utiliser des questions spécifiques permettant d’identifier d’éventuelles attaques de panique et de cerner leur signification pour le patient. Le traitement de premier choix pour ce trouble est une psychothérapie d’orientation cognitivo-comportementale administrée par un psychologue ou un psychiatre spécialisé. Si de telles ressources ne sont pas disponibles, le médecin peut opter pour un traitement psychopharmacologique. CONCLUSION Les médecins de famille peuvent jouer un rôle central dans l’identification et le traitement des patients souffrant d’un TP/A. PMID:17934032

  12. Kyste hydatique du rein : Étude monocentrique de 15 cas

    PubMed Central

    Harrech, Youness El; Abakka, Najib; Anzaoui, Jihad El; Ghoundale, Omar; Touiti, Driss

    2014-01-01

    Objectif : Étudier le profil épidémiologique ainsi que les caractéristiques cliniques, radiologiques, et thérapeutiques du kyste hydatique du rein (KHR). Méthodologie : Quinze cas de KHR colligés de 2004 à 2010 ont été revus. Les données cliniques, radiologiques (arbre urinaire sans préparation, échographie, tomodensitométrie [TDM]) et biologiques (éosinophilie et sérologie hydatique) ont été analysées, et le traitement instauré. L’évolution et les complications ont fait l’objet d’un suivi attentif. Résultats : L’âge moyen de découverte du KHR est de 56,13 ans, avec une prédominance masculine (12 hommes, 3 femmes). La symptomatologie clinique est dominée par les lombalgies (60 % des cas). Une analyse de la sérologie hydatique a été demandée pour six patients et s’est révélée positive pour trois d’entre eux. L’abstention thérapeutique a été l’attitude adoptée par deux malades ayant un kyste hydatique de type 5. Aucun patient n’a reçu de traitement médical seul. Treize patients (86,66 %) ont subi une intervention chirurgicale, dont une résection du dôme saillant pour 11 patients, une néphrectomie partielle pour 1 patient et une néphrectomie totale pour 1 autre patient dont le rein était totalement détruit. Aucune complication peropératoire ou postopératoire n’a été signalée, qu’il s’agisse de fistule urinaire ou d’infection de la cavité résiduelle. Aucune récidive n’a été constatée sur une période moyenne de deux ans. Conclusion : Le KHR est une pathologie rare sans sémiologie spécifique. Si la chirurgie occupe une place primordiale dans le traitement de ces kystes, de nouvelles perspectives mini-invasives restent à explorer, tout particulièrement les traitements percutané et laparoscopique. PMID:25210557

  13. Etude descriptive et analytique du cancer de l’œsophage au Togo

    PubMed Central

    Oumboma, Bouglouga; Mawuli, Lawson-Ananissoh Laté; Aklesso, Bagny; Laconi, Kaaga; Datouda, Redah

    2014-01-01

    Introduction Décrire les aspects épidémiologiques, cliniques, endoscopiques et histologiques du cancer de l’œsophage (CO) au Togo. Méthodes Il s'agit d'une étude rétrospective descriptive et analytique menée sur 8 ans (Janvier 2005-Décembre 2012) dans le service d'hépato-gastroentérologie (HGE) du CHU Campus de Lomé. Etaient inclus les dossiers des patients hospitalisés pour CO confirmé histologiquement. Résultats Sur 8 ans, 24 patients remplissant nos critères d'inclusion ont été retenus soit 3cas de CO par an et 0,55% des hospitalisations. L’âge moyen des patients était de 57,08 ans (extrêmes: 32 et 82 ans). La dysphagie et l’épigastralgie étaient les motifs d'hospitalisation les plus rencontrés. L'alcool (n=15), le tabac (n=13) étaient les facteurs de risque les plus présents. A la fibroscopie, les lésions étaient ulcéro-bourgeonnantes et hémorragiques (n=12), ulcéro-bourgeonnantes (n=5); ces lésions siégeaient au niveau du 1/3 inférieur (n= 11), à l'union 1/3 supérieur 1/3moyen de l’œsophage (n= 13) et aucun au niveau du 1/3 supérieur. Seize lésions étaient des carcinomes épidermoïdes et 3 des adénocarcinomes. L’évolution dans le service a été fatale dans 2cas; 16 patients avaient été transférés en chirurgie pour des soins palliatifs et 5 patients (20,8%) étaient perdus de vue. Conclusion Le CO semble en augmentation au Togo. L'alcool et le tabac sont les facteurs de risque et le pronostic sévère dans notre série est lié au retard diagnostic. Son dépistage précoce passe par une consultation rapide devant toute dysphagie chez un sujet de 50 ans et plus. PMID:25883742

  14. Lac du Flambeau Band of Lake Superior Chippewa Indians Strategic Energy Plan

    SciTech Connect

    Bryan Hoover

    2009-11-16

    This plan discusses the current energy use on the Lac du Flambeau Reservation, the current status of the Tribe's energy program, as well as the issues and concerns with energy on the reservation. This plan also identifies and outlines energy opportunities, goals, and objectives for the Tribe to accomplish. The overall goal of this plan is to address the energy situation of the reservation in a holistic manner for the maximum benefit to the Tribe. This plan is an evolving document that will be re-evaluated as the Tribe's energy situation changes.

  15. Aspects cliniques des cancers bronchopulmonaires primitifs au service d'oncologie du CHUA-HUJRA Antananarivo

    PubMed Central

    Refeno, Valéry; Hasiniatsy, Nomeharisoa Rodrigue Emile; Andrianandrasana, Ny Ony Tiana Florence; Ramahandrisoa, Andriatsihoarana Voahary Nasandratriniavo; Rakotonarivo, Jean Marc; Maevazaka, Joée Larissa; Rakotovao, Hanitrala Jean Louis; Rafaramino, Florine

    2015-01-01

    Le retard de diagnostic des cancers broncho-pulmonaires est l'une des sources du retard de leur prise en charge dans les pays en développement. A notre connaissance, l'aspect clinique des cancers broncho-pulmonaires au Centre Hospitalier Universitaire d'Antananarivo-Hôpital Universitaire Joseph Ravoahangy Andrianavalona (CHUA-HUJRA) n'a jamais été étudié. L'objectif était de décrire les aspects cliniques des cancers broncho-pulmonaires primitifs dans le plus grand centre de cancérologie de Madagascar. C'est une étude rétrospective et descriptive des patients atteints de cancers broncho-pulmonaires primitifs vus au service d'oncologie du CHUA-HUJRA du 1er janvier 2008 au 31 décembre 2013. Nous avons recensé 101 patients (80 hommes et 21 femmes). Les circonstances de découverte sont principalement la toux chronique (n = 29), la dyspnée (n = 16) et l'association d'une hémoptysie à la toux chronique (n = 12). Soixante et onze patients avaient un index de performans status ≥ à 2 au moment du diagnostic. On a retrouvé des bacilles de Koch actives dans le crachat de deux patients. Le délai moyen entre l'apparition des premiers signes et la première consultation était de 11 mois. Le délai moyen entre la première consultation et le diagnostic anatomopathologique était de 3 mois. Le cancer broncho-pulmonaire peut avoir des manifestations cliniques non spécifiques parfois trompeuses qui peuvent retarder leur prise en charge. De ce fait, il doit être recherché devant tout signe respiratoire persistant. Par ailleurs, le délai de prise en charge pré-hospitalière et hospitalière de ces cancers doit être amélioré. PMID:26958134

  16. [[The Lactéol's laboratory of Dr Boucard (Laboratoire du Dr Boucard].

    PubMed

    Raynal, Cécile; Lefebvre, Thierry

    2016-03-01

    Shortly before 1910, Dr Boucard creates his laboratory in Paris. It manufactures and sells a drug based on lactic ferments the " Lactéol du Dr Boucard" (Dr's Boucard Lactéol) that will make the fortune of the physician. The article explains Dr Boucard's life and his relationship with the arts (painting and photography), and tells the story of his laboratory until the 2000s, referring to the pharmacists who succeeded them, as well as the various buildings where were elaborated Lactéol's variants. PMID:27281930

  17. VizieR Online Data Catalog: RM AGNs accretion rates and BH masses (Du+, 2016)

    NASA Astrophysics Data System (ADS)

    Du, P.; Wang, J.-M.; Hu, C.; Ho, L. C.; Li, Y.-R.; Bai, J.-M.

    2016-05-01

    We select all AGNs with reverberation mapping (RM) data (here only broad Hβ line), which yield robust BH mass estimates needed for our analysis. All RM AGNs before 2013 are summarized by Bentz et al. (2013ApJ...767..149B). Our project to search for super-Eddington accreting massive black holes (SEAMBHs) has monitored about 25 candidates and successfully measured Hβ lags ({tau}Hβ) in 14 AGNs to date (Du et al. 2015, J/ApJ/806/22) and other five objects monitored between 2014 and 2015 (to be submitted). See section 2 for further explanations. (2 data files).

  18. Analysis of DuPont and Kodak duplicating films and chemistries in a Fultron spray processor

    NASA Technical Reports Server (NTRS)

    Weinstein, M. S.

    1972-01-01

    A test program was conducted with duPont duplicating film type SR 112 and SCOLOR developer and Kodak duplicating film types 2430, 2422, and FE 2628 (SO-467) and MX-641 developer to determine sensitometric and image quality characteristics of these materials when used with a fultron spray processor. The test results show that the SCOLOR developer foams excessively in the fultron processor when used with or without the addition of an antifoaming agent. The Kodak type FE 2628 film with MX-641 chemistry had the longest linear Log E range at a 1.0 gamma. Sensitometric curves and granularity traces for all film process combinations tested are included.

  19. CSP (du Pont) Classification of a Type Ia SN LSQ13ccg

    NASA Astrophysics Data System (ADS)

    Walker, E. S.; Hadjiyska, E.; Rabinowitz, D.; Baltay, C.; Ellman, N.; McKinnon, R.; Feindt, U.; Nugent, P.; Morrell, N.; Prieto, J.; Hsiao, E. Y.; Phillips, M.

    2013-09-01

    We report the classification of LSQ13ccg (23:03:11.45 +14:41:39.1) as a Type Ia supernova near maximum light. The supernova was first detected by LSQ (La Silla-QUEST - Baltay et al. PASP 125 683) on September 1.1 at V = 19.4 and was followed-up by the Carnegie Supernova Project using the du Pont Telescope with WFCCD on 2013 September 3. The supernova is found to be at z = 0.077. The spectrum also shows strong emission from a nearby HII region in the host at the same redshift.

  20. CSP (du Pont) Classification of a Type Ia SN LSQ13caz

    NASA Astrophysics Data System (ADS)

    Hadjiyska, E.; Walker, E. S.; Rabinowitz, D.; Baltay, C.; Ellman, N.; McKinnon, R.; Feindt, U.; Nugent, P.; Morrell, N.; Prieto, J.; Hsiao, E. Y.; Phillips, M.

    2013-09-01

    We report the classification of type Ia SN LSQ13caz near maximum light (La Silla-QUEST - Hadjiyska et al., ATel#3812) by the Carnegie Supernova Project using the du Pont Telescope (+WFCCD) on 2013 September 2 at z = 0.123. At that redshift, the minimum of SiII 635.5nm is blueshifted by ~ 12100 km/s. LSQ13caz (RA = 21:20:56.62, Dec = -08:51:28.1) was discovered by LSQ on August 25.075 at V= 20.4.

  1. COMMENT: An external attack on the Brádler Dušek protocol

    NASA Astrophysics Data System (ADS)

    Qin, Su-Juan; Wen, Qiao-Yan; Zhu, Fu-Chen

    2007-12-01

    The two quantum secret sharing protocols in the paper of Brádler and Dušek (2004 J. Opt. B: Quantum Semiclass. Opt. 6 63) are analysed and it is shown that both protocols are insecure not only for a dishonest participant but also for an external eavesdropper. An external eavesdropper Eve can steal half of Alice's secret without being detected, if she employs a special attack strategy. We give a possible way to improve the protocol to withstand this attack.

  2. Cancer du sein au Cameroun, profil histo-épidémiologique: à propos de 3044 cas

    PubMed Central

    Engbang, Jean Paul Ndamba; Essome, Henri; Koh, Valère Mve; Simo, Godefroy; Essam, Jean Daniel Sime; Mouelle, Albert Sone; Essame, Jean Louis Oyono

    2015-01-01

    Décrire les caractéristiques épidémiologiques et histo-pathologiques des tumeurs malignes du sein au Cameroun. Il s'agissait d'une étude rétrospective descriptive portant sur les tumeurs malignes du sein, colligées, dans les registres des différents laboratoires d'Anatomie Pathologique publiques et privés repartis dans cinq régions (centre, littoral, Ouest, Nord-ouest, Sud-ouest), pendant une période de 10 ans (2004-2013). Les paramètres étudiés étaient la fréquence, l’âge, le sexe, la localisation, le type et le grade histologique, et les récepteurs hormonaux. Un total de 3044 cas de cancers du sein a été recensé, soit une fréquence annuelle de 304,4 cas en moyenne. Le sexe féminin était le plus représenté avec 2971 cas (97,60%) et les hommes avec 73 cas (2,40%), soit un sexe ratio (H/F) de 0,02. L’âge moyen des patients était de 46±15,87 ans, avec des extrêmes de 13 et 95 ans. Selon la localisation, le sein gauche était atteint dans 1244 cas (52%) et le sein droit dans 1115 cas (47%). Au plan histologique, on retrouvait essentiellement des carcinomes avec 96,50% des cas, des sarcomes 1,39%, des lymphomes 1,07% et la maladie de Paget du mamelon, 1,03%. Les tumeurs épithéliales étaient infiltrantes dans 2049 cas (84,46%), avec une prédominance du carcinome canalaire infiltrant (1870 cas) et non infiltrantes dans 377 cas (15,54%). Le grade histo-pronostic de SBR avait révélé une prédominance du grade II dans 66% des cas. Les cancers du sein restent une pathologie fréquente au Cameroun et atteignent principalement la population féminine en âge de procréer. Ils sont caractérisés par la prédominance du carcinome canalaire infiltrant. PMID:26523182

  3. Sirénomélie (Mermaid Syndrome): description du premier cas Congolais et revue de la literature

    PubMed Central

    Lubala, Toni Kasole; Mukuku, Olivier; Mutombo, Augustin Mulangu

    2014-01-01

    La sirénomélie est une forme rare de dysgénésie caudale généralement incompatible avec la vie du fait des malformations rénales graves qui y sont associées. En Afrique, elle est associée à des considérations mystico-religieuses et à la sorcellerie et expose la famille à une stigmatisation violente. Son étiologie est encore très controversée. A notre connaissance, il s'agit du premier cas congolais rapporté dans la littérature. PMID:25120875

  4. Le contrôle des infections au cabinet du pédiatre

    PubMed Central

    2008-01-01

    RÉSUMÉ La transmission des infections au cabinet du pédiatre est de plus en plus préoccupante. Le présent document expose les voies de transmission des infections et les principes sous-jacents aux mesures actuelles pour contrôler les infections. Pour prévenir les infections, il faut bien concevoir le cabinet et adopter des politiques administratives et de triage convenables, de même que des pratiques de base pour les soins de tous les patients (p. ex., hygiène des mains, port de gants, de masques, de lunettes de protection et d’une blouse d’hôpital pour des interventions précises; nettoyage, désinfection et stérilisation convenables des surfaces et du matériel, y compris les jouets, et techniques d’asepsie en cas d’interventions effractives) et des précautions additionnelles en cas d’infections précises. Le personnel doit avoir reçu les vaccins pertinents, et les personnes infectées doivent respecter les politiques de restriction au travail.

  5. Curiethérapie dans le traitement palliatif du cancer de l’œsophage

    PubMed Central

    Toulba, Ahmedou; Bakkali, Hanae; Boutayeb, Salwa; Kebdani, Tayeb; Ahid, Samir; Benjaafar, Noureddine

    2015-01-01

    Les patients atteints du cancer de l’œsophage ont souvent une maladie localement avancée, la dysphagie est le symptôme majeur chez la plupart de ces patients, plusieurs modalités thérapeutiques ont été utilisées pour améliorer cette dysphagie. Le but de ce travail est d’étudier l'efficacité et la tolérance de la curiethérapie haut débit de dose (HDR) endo-luminale dans le traitement palliatif des cancers de l’œsophage inopérable. Sur une période de 15 ans, l’étude a inclus les patients atteints de cancer de l’œsophage inopérable et/ou métastatique avec une dysphagie, sans extension à l'hypopharynx ou a la trachée et qui ont bénéficié d'une curiethérapie HDR avec ou sans radiothérapie externe à visée palliative. Au total 46 patients ont été inclus dans l’étude, 58,7% étaient des hommes, 42,2% avaient une dysphagie grade 2 et 37,8% étaient aphagiques, 78,6% des patients étaient performance satus PS 2, l'amaigrissement à été trouvé chez 81,4%, la localisation de la tumeur était surtout au niveau du tiers moyen et inférieur dans 97,8%, la hauteur médiane de la tumeur était de 7 cm (5,5-9), le carcinome épidermoïde était le type histologique le plus fréquent chez 31 patients (70,5%). Après un médiane de suivi de 5 mois, l'amélioration de la dysphagie a été retrouvée chez 76% des malades (p1]. L′incidence la plus élevée est observée dans certains pays notamment en Asie et en Afrique, et l′incidence dans les pays développés occidentaux est en augmentation [2]. Selon le registre du cancer de Rabat 2006-2008, le cancer de l’œsophage est rare et constitue 1,5% de tous les cancers chez l'homme [3]. Le taux de survie globale à 5 ans est de 8%, avec 80% des décès liés à l’évolution locale de la maladie [4]. Pour la minorité des patients avec une maladie localisée, le traitement par radiochimiothérapie concomitante avec ou sans chirurgie permet une amélioration de la survie [5]. Plus de 50

  6. The Reality of Neandertal Symbolic Behavior at the Grotte du Renne, Arcy-sur-Cure, France

    PubMed Central

    Caron, François; d'Errico, Francesco; Del Moral, Pierre; Santos, Frédéric; Zilhão, João

    2011-01-01

    Background The question of whether symbolically mediated behavior is exclusive to modern humans or shared with anatomically archaic populations such as the Neandertals is hotly debated. At the Grotte du Renne, Arcy-sur-Cure, France, the Châtelperronian levels contain Neandertal remains and large numbers of personal ornaments, decorated bone tools and colorants, but it has been suggested that this association reflects intrusion of the symbolic artifacts from the overlying Protoaurignacian and/or of the Neandertal remains from the underlying Mousterian. Methodology/Principal Findings We tested these hypotheses against the horizontal and vertical distributions of the various categories of diagnostic finds and statistically assessed the probability that the Châtelperronian levels are of mixed composition. Our results reject that the associations result from large or small scale, localized or generalized post-depositional displacement, and they imply that incomplete sample decontamination is the parsimonious explanation for the stratigraphic anomalies seen in the radiocarbon dating of the sequence. Conclusions/Significance The symbolic artifacts in the Châtelperronian of the Grotte du Renne are indeed Neandertal material culture. PMID:21738702

  7. O'Connell effect in early-type contact binaries: du Boo and AG Vir

    NASA Astrophysics Data System (ADS)

    Pribulla, T.; Vaňko, M.; Chochol, D.; Hambálek, Ľ.; Parimucha, Š.

    2011-07-01

    The paper presents new photoelectric observations of the eclipsing binary systems DU Boo and AG Vir. The systems are somewhat similar - both are A-type contact binaries with the maximum following the primary minimum being the brighter one. This light curve asymmetry is extremely temporally stable. The phase dependence of the color indices is unexpectedly small for the observed amplitude of the O'Connell effect, amounting to about 0.1 mag in the optical wavelength range which indicates a very large heated area with a temperature contrast of {Δ T ≈} 1000-1500 K. The broadening functions (BFs) of the systems do not show any dark solar-type photospheric spots. On the other hand, there are significant differences of BFs between the quadratures (surprisingly similar in both systems) indicative of stream of matter or bright region causing additional emission seen between the components around the phase 0.25. Absolute parameters of the components slightly depend on the adopted model. Long orbital period of both contact binaries combined with late spectral type indicate that the primary components of either of the systems (but particularly in case of DU Boo) already evolved off the main sequence. Based on spectroscopic data from the David Dunlap Observatory, University of Toronto

  8. [The image of animal magnetism in fictional literature: the cases of Poe, Doyle and Du Maurier].

    PubMed

    Bonet Safont, Juan Marcos

    2014-01-01

    In this article, we focus on the social image of the phenomenon known as mesmerism, or animal magnetism, through analysis of the works: The Facts in the Case of M. Valdemar (1845) by Edgar Allan Poe, The Great Keinplatz Experiment (1885) by Conan Doyle and Trilby (1894) by George Du Maurier. We describe the stereotype of the mesmerist and the uses of mesmerism observed. We pay attention to the spaces and actors of the mesmeric transcript presented in the stories. We consider the reception of these stories by the public and the relationship of the authors with mesmeric and hypnotic knowledge. Nowadays, academic researchers in the discipline of psychology publish articles and books on popular myths about hypnosis in attempts to depict the distorted images related to this phenomenon. This distorted image of the hypnotic process and the hypnotist derives from "circus" hypnotism shows (stage hypnosis), the cinema, television and fictional literature. Works of fiction represent a unique and invaluable source of information, ideas, speculations, concerns and opportunities around animal magnetism and hypnosis, and the exploration and analysis of this literature is an essential chapter in any historical study of this topic. We see how the literary use of mesmerism by Poe, Doyle and Du Maurier is not chance or peripheral, with all three being intellectually interested in and stimulated by these ideas. PMID:25508821

  9. Prise en Charge du Syndrome de Lyell ou Necrolyse Epidermique Toxique

    PubMed Central

    Siah, S.; Baite, A.; Bakkali, H.; Atmani, M.; Ababou, K.; Ihrai, H.

    2009-01-01

    Summary Le syndrome de Lyell ou nécrolyse épidermique toxique (NET) est une pathologie très grave des dermatoses bulleuses d'étiologie médicamenteuse. Il se caractérise par une nécrose aiguë de l'épiderme sur toute la hauteur du corps muqueux. L'aspect clinique de la NET est celui d'une brûlure étendue du deuxième degré profond. A ce tableau s'associent constamment des lésions muqueuses et une atteinte multiviscérale qui aggrave le pronostic. Nous rapportons deux cas de NET qui illustrent l'importance d'une prise en charge précoce et multidisciplinaire de ces patients atteints au sein d'un service de réanimation des brûlés, dont les fondements reposent sur l'asepsie rigoureuse, l'apport hydroélectrolytique et nutritionnel, la prévention de l'infection et son traitement par une antibiothérapie adaptée, et un nursing et des soins locaux. L'efficacité supposée des immunoglobulines intraveineuses ne repose que sur des cas isolés et il n'y a pas encore d'études randomisées. PMID:21991170

  10. Wetlands of Argonne National Laboratory-East DuPage County, Illinois

    SciTech Connect

    Van Lonkhuyzen, R.A.; LaGory, K.E.

    1994-03-01

    Jurisdictional wetlands of the Argonne National Laboratory-East (ANL-E) site in DuPage County, Illinois, were delineated in the summer and autumn of 1993 in accordance with the 1987 US Army Corps of Engineers methodology. Potential wetland sites with an area greater than 500 m{sup 2} (0.05 ha [0.124 acre]) were identified for delineation on the basis of aerial photographs, the DuPage County soil survey, and reconnaissance-level field studies. To qualify as a jurisdictional wetland, an area had to support a predominance of hydrophytic vegetation as well as have hydric soil and wetland hydrology. Thirty-five individual jurisdictional wetlands were delineated at ANL-E, totaling 180,604 m{sup 2} (18.1 ha [44.6 acres]). These wetlands were digitized onto the ANL-E site map for use in project planning. Characteristics of each wetland are presented -- including size, dominant plant species and their indicator status, hydrologic characteristics (including water source), and soil characteristics.

  11. [The image of animal magnetism in fictional literature: the cases of Poe, Doyle and Du Maurier].

    PubMed

    Bonet Safont, Juan Marcos

    2014-01-01

    In this article, we focus on the social image of the phenomenon known as mesmerism, or animal magnetism, through analysis of the works: The Facts in the Case of M. Valdemar (1845) by Edgar Allan Poe, The Great Keinplatz Experiment (1885) by Conan Doyle and Trilby (1894) by George Du Maurier. We describe the stereotype of the mesmerist and the uses of mesmerism observed. We pay attention to the spaces and actors of the mesmeric transcript presented in the stories. We consider the reception of these stories by the public and the relationship of the authors with mesmeric and hypnotic knowledge. Nowadays, academic researchers in the discipline of psychology publish articles and books on popular myths about hypnosis in attempts to depict the distorted images related to this phenomenon. This distorted image of the hypnotic process and the hypnotist derives from "circus" hypnotism shows (stage hypnosis), the cinema, television and fictional literature. Works of fiction represent a unique and invaluable source of information, ideas, speculations, concerns and opportunities around animal magnetism and hypnosis, and the exploration and analysis of this literature is an essential chapter in any historical study of this topic. We see how the literary use of mesmerism by Poe, Doyle and Du Maurier is not chance or peripheral, with all three being intellectually interested in and stimulated by these ideas. PMID:25481969

  12. Hématome post traumatique du muscle iléopsoas avec paralysie du nerf fémoral: à propos d'un cas et revue de la littérature

    PubMed Central

    Sallahi, Hicham; Margad, Omar; Lamkhantar, Adil; idrissi, Khalid Koulali

    2015-01-01

    L'hématome compressif du muscle iliopsoas dans le petit bassin est une complication connue des traitements anticoagulants, mais reste rare en post-traumatique. La présente observation illustre un cas de cet hématome chez un adolescent de 14 ans qui s'est présenté avec une douleur post-traumatique de la cuisse et un déficit actif d'extension de la jambe évoluant depuis plus de 3 mois. Un examen clinique a montré l'existence d'une paralysie complète du quadriceps. Une IRM du petit bassin a retrouvé un volumineux hématome du muscle iliopsoas comprimant le nerf fémoral. Un drainage chirurgical de l'hématome a été réalisé. La récupération musculaire était partielle après six mois de recul. PMID:26113929

  13. L’effet du yoga chez les patients atteints de cancer

    PubMed Central

    Côté, Andréanne; Daneault, Serge

    2012-01-01

    Résumé Objectif Déterminer si le yoga thérapeutique améliore la qualité de vie de patients atteints de cancer. Sources des données Recherche effectuée avec la base de données MEDLINE (1950–2010) en utilisant les mots-clés yoga, cancer et quality of life. Sélection des études Priorité accordée aux études cliniques randomisées contrôlées évaluant l’effet du yoga sur différents symptômes susceptibles de se présenter chez des patients atteints de cancer en Amérique du Nord. Synthèse Quatre études cliniques randomisées contrôlées ont d’abord été analysées, puis 2 études sans groupe-contrôle. Trois études réalisées en Inde et au Proche-Orient ont également apporté des éléments intéressants au plan méthodologique. Les interventions proposées comprenaient des séances de yoga d’une durée et d’une fréquence variables. Les paramètres mesurés variaient également d’une étude à l’autre. Plusieurs symptômes ont connu des améliorations significatives avec le yoga (meilleure qualité du sommeil, diminution des symptômes anxieux ou dépressifs, amélioration du bien-être spirituel, etc.). Il a aussi semblé que la qualité de vie, dans sa globalité ou dans certaines de ses composantes spécifiques, s’améliorait. Conclusion La variété des effets bénéfiques produits, l’absence d’effet secondaire et le rapport coût-bénéfice avantageux du yoga thérapeutique en fait une intervention intéressante à suggérer par les médecins de famille aux patients atteints de cancer. Certaines lacunes méthodologiques ont pu diminuer la puissance statistique des études présentées, à commencer par la taille restreinte des échantillons et par l’assiduité variable des patients soumis à l’intervention. Il est également possible que les échelles de mesure utilisées ne convenaient pas à ce type de situation et de clientèle pour qu’en soit dégagé un effet significatif. Toutefois, les commentaires

  14. Resonance-enhanced two-photon ionization of helium using an Ar{sup +} mode-locked laser synchronized with VUV synchrotron radiation pulses

    SciTech Connect

    Lacoursiere, Jean; Meyer, Michael; Nahon, Laurent; Morin, Paul; Larzilliere, Michel

    1995-04-01

    We report a new experimental set-up consisting in the synchronization of 74.9094 MHz pulses from a mode-locked Ar{sup +} laser with 8.32 MHz pulses of vacuum ultraviolet (VUV) synchrotron radiation from the Super-ACO storage ring of the Laboratorie pour l'Utilisation du Rayonnement Electromagnetique (LURE). The capabilities of the set-up are demonstrated in a time-resolved pump-probe (VUV+visible) experiment in which free helium atoms are resonantly ionized via the short-lived 1s3p ({sup 1}P) state. This experiment allowed us to show the relevance of this technique for the investigation of nanosecond dynamics on gas phase species.

  15. Resonance-enhanced two-photon ionization of helium using an Ar+ mode-locked laser synchronized with VUV synchrotron radiation pulses

    NASA Astrophysics Data System (ADS)

    Lacoursière, Jean; Meyer, Michael; Nahon, Laurent; Morin, Paul; Larzillière, Michel

    1995-04-01

    We report a new experimental set-up consisting in the synchronization of 74.9094 MHz pulses from a mode-locked Ar+ laser with 8.32 MHz pulses of vacuum ultraviolet (VUV) synchrotron radiation from the Super-ACO storage ring of the Laboratorie pour l'Utilisation du Rayonnement Electromagnetique (LURE). The capabilities of the set-up are demonstrated in a time-resolved pump-probe (VUV+visible) experiment in which free helium atoms are resonantly ionized via the short-lived 1s3p (1P) state. This experiment allowed us to show the relevance of this technique for the investigation of nanosecond dynamics on gas phase species.

  16. Epidémiologie et prise en charge des infections du per-partum à la maternité du centre hospitalier départemental de l'Ouémé-Plateau au Bénin

    PubMed Central

    Saizonou, Jacques; Ouédraogo, Laurent; Paraiso, Moussiliou Noël; Ayélo, Paul; Kpozèhouen, Alphonse; Daraté, René; Traoré, Esther

    2014-01-01

    Introduction La présente étude avait pour objectif de mesurer l'ampleur des infections du per-partum à la maternité du Centre Hospitalier Départemental de l'Ouémé-Plateau d'analyser les conditions de survenue et de prise en charge dans la perspective de l'amélioration des soins et services maternels et néonataux. Méthodes Une étude descriptive et analytique a été conduite de Août 2009 à Février 2010 et a impliqué 110 mères victimes d'infections du per-partum; elles ont été soumises à un questionnaire durant tout leur séjour hospitalier; des observations des pratiques de prise en charge des prestataires de soins ont été menées et des registres et autres supports de données sanitaires ont été exploités. L'analyse des données a été effectuée à l'aide du logiciel Epi Info 6.4 dans sa version française. Résultats L'incidence des infections du per-partum était de 5,9 pour 100 accouchements (110/ 1875); les types d'infections les plus incriminés étaient les endométrites (27,3%), les chorioamniotites (18,2%), les infections du site opératoire (12,7%) et les infections urinaires (2,7%). Les examens cliniques ont été relativement acceptables. En revanche, les examens biologiques ont été très insuffisants expliquant l'imprécision importante au niveau des diagnostics. L'antibiothérapie a été instaurée systématiquement. Le taux de mortinaissance était de 25,6% et les enfants de petit poids représentaient 23,2%. Conclusion L'incidence des infections du per-partum dans la présente étude était assez élevée. Des efforts de préventions et de dépistage de ces infections sont nécessaire afin d'améliorer la qualité des soins PMID:25120854

  17. Les accidents du travail dans le transport urbain en commun de la ville province de Kinshasa, République Démocratique du Congo: une étude transversale descriptive

    PubMed Central

    Wangata, Jemima; Elenge, Myriam; De Brouwer, Christophe

    2014-01-01

    Introduction Le transport en commun urbain constitue un secteur où les travailleurs sont très exposés aux accidents du travail. Cette étude visait une description épidémiologique des accidents du travail dans le secteur informel du transport en commun à Kinshasa en vue d'apporter les pistes d'amélioration de la sécurité des travailleurs dans cette activité. Méthodes Un questionnaire sur les accidents du travail, administré en Décembre 2012 a permis d'explorer les tendances significatives entre les accidents et leurs circonstances, leurs facteurs associés, leurs conséquences au sein d'une population des travailleurs (n = 472) du transport en commun à Kinshasa. Résultats Durant les 12 derniers précédant l’étude 76.5% des travailleurs ont connu au moins un accident du travail, 54,8% ont connu un arrêt d'au moins 1jour. Les accidents liés à la circulation routière étaient plus important suivis des chutes. Les facteurs ayant montré des différences significatives étaient le travail sous l'influence de l'alcool et le port des équipements de protection individuelle. Les plaies (46,3%) et les contusions (39,4%) étaient les lésions les plus courantes. Les membres supérieurs (51,3%) et inférieurs (30,7%) étaient les plus atteints. 76,6% des travailleurs ont assumé seuls leur prise en charge médicale. Conclusion L'incidence des accidents du travail dans ce secteur est très élevée. La mise en place d'une politique de prévention et gestion de différents facteurs associés ainsi qu'un système de déclaration d'accidents est nécessaire dans ce secteur. Les patrons ainsi que les politiques devraient veiller à une prise en charge médicale correcte pour des travailleurs accidentés. PMID:25667703

  18. Etude de facteurs de risque de la transmission du VIH de la mère à l'enfant dans la stratégie « option A » à Lubumbashi, République Démocratique du Congo

    PubMed Central

    Ngwej, Dieudonné Tshikwej; Mukuku, Olivier; Mudekereza, Rachel; Karaj, Eugénie; Odimba, Etienne Bwana Fwamba; Luboya, Oscar Numbi; Kakoma, Jean-Baptiste Sakatolo; Wembonyama, Stanis Okitotshio

    2015-01-01

    Introduction L'infection à VIH chez la femme enceinte a pour principal risque la contamination du nouveau-né. L'objectif est de déterminer le taux de transmission du VIH de la mère à l'enfant (TME) dans la ville de Lubumbashi et en évaluer les facteurs de risque. Méthodes Il s'agissait d'une étude prospective transversale à visée analytique de 157 accouchées séropositives au VIH et de leurs enfants dans 12 structures sanitaires de Lubumbashi (RDCongo) du 1er octobre 2012 au 31 décembre 2013. Les paramètres sociodémographiques, cliniques et les données relatives aux activités de PTME du VIH ont été étudiés. Les statistiques usuelles ont été utilisées pour analyser les résultats. Le seuil de significativité a été fixé à une valeur de p < 0,05. Résultats Le taux de transmission verticale du VIH était de 12,7% (20/157). Il n'y avait pas d'association significative entre les caractéristiques sociodémographiques maternelles telles que l’âge, la parité, le niveau d’étude, la profession et l’état-civil et la TME (p>0,05). La transmission verticale du VIH était significativement associée aux facteurs suivants: le stade clinique 3 de l'OMS (OR=5,18 (1,5-18,1)), la présence d'infection opportuniste (OR=8,7 (2,7-27,8)), le dépistage lors de l'accouchement (OR=6,3 (1,0-39,0)) ou au cours de l'allaitement (OR=7,1 (1,1-76,7)), au taux de CD4 maternel <350/mm3 (OR=2,9 (1,1-7,7)), l'absence de thérapie antirétrovirale chez la mère (OR=19,9 (4,8-81,9)), la naissance avant terme (OR=4,7 (1,4-16,0)), la rupture prématurée de membranes (OR=45,0 (7,4-454,6)), le faible poids de naissance (OR=5,6 (1,9-16,7)), la notion de réanimation néonatale (OR=12,4 (3,8-40,1)), la non administration de la névirapine à la naissance (OR=26,4 (7,6-92,3)) et l'alimentation mixte (OR=12,6 (1,3-115,9)). Le sexe du nourrisson et le mode d'accouchement n’étaient pas non plus associés à la transmission verticale du VIH (p>0,05). Conclusion Le taux

  19. Léiomyosarcome du pancréas: une tumeur de mauvais pronostic - cas clinique et revue de la littérature

    PubMed Central

    Laalim, Said Ait; Hijri, Fatim Zahra; Kamaoui, Imane; Hassani, Karim Ibn Majdoub; Toughai, Imane; Mazaz, Khalid

    2012-01-01

    Le léiomyosarcome (LMS) primitif du pancréas est une tumeur mésenchymateuse rare (0,1% des tumeurs pancréatiques), seulement 47 cas ont été publiés la littérature depuis 1951. Le diagnostique est basée sur l’immunohistochimie. C’est une tumeur très agressive et souvent découverte à un stade avancé. Nous rapportant le cas d’un patient de 40 ans qui présentait un léiomyosarcome primitif du pancréas de la queue du pancréas avec envahissement de la rate et la partie gauche du colon transverse. Une spléno-pancréatectomie caudale carcinologique avec une colectomie segmentaire était réalisée. Des nodules péritonéaux ont apparus 2 mois après l’intervention au niveau du site opératoire et le paient est décédé 3 mois en postopératoire. Le LMS primitif du pancréas doit être évoqués devant les volumineuses tumeurs du pancréas. Une chirurgie carcinologique est le seul traitement curatif. Le pronostic de ces tumeurs est mauvais et la médiane de survie de ces tumeurs ne dépasse pas 2 ans. PMID:23024830

  20. Traces of DU in samples of environmental bio-monitors (non-flowering plants, fungi) and soil from target sites of the Western Balkan region.

    PubMed

    Zunić, Zora S; Mietelski, Jerzy W; Błazej, Sylwia; Gaca, Paweł; Tomankiewicz, Ewa; Ujić, Predrag; Celiković, Igor; Cuknić, Olivera; Demajo, Miroslav

    2008-08-01

    This paper reports results of gamma and alpha spectrometric measurements for mosses, lichens, fungi and soil samples from areas in the Balkans targeted by depleted uranium (DU). Samples were collected in 2002 and 2003 in the vicinity of several villages, principally Han Pijesak (Bosnia and Herzegovina, hit by DU in 1995) and Bratoselce (South Serbia, hit by DU in 1999) and in lesser numbers from Gornja Stubla, Kosovo (which is identified as a high natural radon/thoron area) and Presevo close to the Kosovo border. In the course of gamma spectrometric measurements some results suggested samples with unusual high uranium contents which might be considered to be a signature for the presence of DU, although many samples had very high detection limits. Alpha spectrometric measurements directly proved the presence of DU for five samples, all from directly targeted places. These were samples of mosses, lichens and soil. For some samples homogeneity tests were applied which showed a rather even distribution of DU in these samples. No trace of DU was found in any sample from a dwelling. PMID:18502546

  1. GPNMB/OA protein increases the invasiveness of human metastatic prostate cancer cell lines DU145 and PC3 through MMP-2 and MMP-9 activity

    SciTech Connect

    Fiorentini, Chiara; Bodei, Serena; Bedussi, Francesca; Fragni, Martina; Bonini, Sara Anna; Simeone, Claudio; Zani, Danilo; Berruti, Alfredo; Missale, Cristina; Memo, Maurizio; Spano, PierFranco; Sigala, Sandra

    2014-04-15

    Non-metastatic glycoprotein melanoma protein B (GPNMB), also known as osteoactivin (OA) is expressed in a wide array of tumors and represents an emerging target for drug development. In this study, we investigated the role of GPNMB/OA in the progression of human metastatic DU145 and PC3 prostate cancer cells. GPNMB/OA contribution in PCa malignant phenotype has been analyzed by small interfering RNA-induced GPNMB/OA silencing. We found that following GPNMB/OA silencing the migration capability of both DU145 and PC3 cells, evaluated by using in vitro invasivity assay, as well as the metalloproteinases MMP-2 and MMP-9 activity were equally strongly inhibited. By contrast knocking down GPNMB/OA weakly attenuated cell proliferation rate of DU145, an effect that paralleled with an increase number of apoptotic cells. However, PC3 cell growth seems to be not affected by GPNMB/OA. Together, these data reveal that GPNMB/OA acts as a critical molecular mediator promoting the acquisition of the more aggressive, pro-metastatic phenotype distinctive of human DU145 and PC3 cell lines. - Highlights: • GPNMB/OA expression correlates with DU145 and PC3 cells malignant phenotype. • GPNMB/OA silencing affects the migration capability of both DU145 and PC3 cells. • GPNMB/OA increases invasiveness by up-regulating MMPs activity. • GPNMB/OA promotes DU145 and PC3 cells progression into a more aggressive phenotype.

  2. La tumeur desmoïde du mésentère: cause rare de masse abdominale chez la femme

    PubMed Central

    Boujoual, Majdouline; Amrani, Mariam; Bougtab, Abdesslam

    2014-01-01

    La tumeurdesmoïde du mésentèreest unetumeur fibreuse localement invasive, sans pouvoir métastatique, mais avec une tendance à la récidive. Du fait de sa rareté, ses circonstances de découverte très variées et son expression clinique aspécifique, elle pose un problème majeur de prise en charge thérapeutique. Nous rapportons un nouveaucas de tumeurdesmoïde du mésentère chez une femme de 35 ansprésentant un tableau de masse abdominale. La tomodensitométrieétait en faveur d'une tumeur solide du péritoine en contact intime avec une anse jéjunale. Unerésection - anastomosedu segment intestinal a été réalisée du fait du caractère envahissant de la tumeur. L'examen histologiqueconfirmé le diagnostic de tumeur desmoïde du mésentère infiltrant le méso grêlique sans atteinte de la paroi intestinale. PMID:25309657

  3. Particularités de la cardiomyopathie du péripartum en Afrique: le cas du Togo sur une étude prospective de 41 cas au Centre Hospitalier et Universitaire Sylvanus Olympio de Lomé

    PubMed Central

    Pio, Machihude; Afassinou, Yaovi; Baragou, Soodougoua; Akue, Edem Goeh; Péssinaba, Souleymane; Atta, Borgatia; Ehlan, Koffi; Alate, Amouzou; Damorou, Findibe

    2014-01-01

    Introduction La cardiomyopathie du péripartum (CMPP) est une défaillance cardiaque dont l’étiologie demeure encore méconnue. Méthodes Il s'agit d'une étude prospective descriptive réalisée dans le service de cardiologie du CHU Sylvanus olympio de Lomé du 1er janvier 2010 au 30 avril 2012. Elle a concerné 41 patientes ayant présenté une insuffisance cardiaque entre le 8eme mois de la grossesse et les 5 premiers mois du post-partum. Résultats L’âge moyen des patientes était de 31,47 ans (extrêmes 21 et 44ans). L'incidence de la CMPP était de 1/362 grossesses. La parité moyenne était de 3,07 (extrêmes 1 et 6). Les symptômes étaient apparus dans le post-partum dans 90,24% des cas. Un retard important de diagnostic était observé. L'insuffisance cardiaque globale était le mode de décompensation dans 65,85%. Les signes électrocardiographiques étaient essentiellement la tachycardie sinusale (97,56%) et l'hypertrophie ventriculaire gauche (97,56%). L’échographie cardiaque a montré dans tous les cas une cardiomyopathie dilatée. Quatre cas de thrombus intraventriculaire gauche étaient notés. La FEVG était sévèrement altérée. L'HTAP était importante dans 56,09%. Conclusion La cardiomyopathie du péripartum est une complication cardiaque grave de la grossesse de cause inconnue, fréquente dans la population africaine. PMID:25309645

  4. The Educational Philosophies of Washington, DuBois, and Houston: Laying the Foundations for Afrocentrism and Multiculturalism.

    ERIC Educational Resources Information Center

    Dunn, Frederick

    1993-01-01

    The following three African-American philosophical orientations to education have achieved prominence over the years: (1) the accommodationist philosophy of Booker T. Washington; (2) the radical, liberationist approach of W. E. B. DuBois; and (3) the integrationist/desegregationist, reformist philosophy of Charles H. Houston. Each philosophical…

  5. Psychological Well-Being in Parents of Children with Angelman, Cornelia de Lange and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Griffith, G. M.; Hastings, R. P.; Oliver, C.; Howlin, P.; Moss, J.; Petty, J.; Tunnicliffe, P.

    2011-01-01

    Background: The current study focuses on mothers and fathers of children with three rare genetic syndromes that are relatively unexplored in terms of family experience: Angelman syndrome, Cornelia de Lange syndrome and Cri du Chat syndrome. Method: Parents of children with Angelman syndrome (n = 15), Cornelia de Lange syndrome (n = 16) and Cri du…

  6. 76 FR 82031 - Public Notice for Waiver of Aeronautical Land-use Assurance; DuPage Airport, West Chicago, IL

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ... Federal Aviation Administration Public Notice for Waiver of Aeronautical Land-use Assurance; DuPage... change a portion of airport land from aeronautical use to non-aeronautical use and to authorize the sale... compatible land use and is not needed for aeronautical use, as shown on the Airport Layout Plan. The...

  7. 75 FR 78985 - County of DuPage; Notice of Preliminary Permit Application Accepted for Filing and Soliciting...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-17

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission County of DuPage; Notice of Preliminary Permit Application Accepted for Filing and Soliciting Comments, Motions To Intervene, and Competing Applications December 10, 2010. On September 21, 2010, the County of...

  8. Program Evaluation: Outcomes of Participation in Lac Du Bois, the French Language Village of Concordia Language Villages

    ERIC Educational Resources Information Center

    Clementi, Donna L.

    2012-01-01

    The purpose of this study was to describe perceptions of stakeholders (leadership of Concordia Language Villages, staff members and villagers of "Lac du Bois", the French Language Village of Concordia Language Villages), related to achievement of the mission statement. The research question was: How do stakeholders in "Lac du…

  9. "To Break Asunder along the Lesions of Race". The Critical Race Theory of W.E.B. Du Bois

    ERIC Educational Resources Information Center

    Rashid, Kamau

    2011-01-01

    In addition to its beginnings within legal scholarship, Critical Race Theory (CRT) is intimately aligned with the long tradition of African American social critique, which sought to interrogate the intractable nature of racism and White supremacy. Within this intellectual tradition, the works of W.E.B. Du Bois are of critical significance. Du…

  10. Soaring to Excellence 2000: You Have the Power! Teleconference for Library Personnel, College of DuPage.

    ERIC Educational Resources Information Center

    Slusar, Linda, Comp.

    The Soaring to Excellence staff development series of the College of DuPage provides the tools to empower library personnel in the workplace. Each teleconference in the series is supported by practical information, discussion questions, worksheets, and bibliographies. Students are provided with the opportunity to view and participate in three live…

  11. Using a probabilistic approach in an ecological risk assessment simulation tool: test case for depleted uranium (DU).

    PubMed

    Fan, Ming; Thongsri, Tepwitoon; Axe, Lisa; Tyson, Trevor A

    2005-06-01

    A probabilistic approach was applied in an ecological risk assessment (ERA) to characterize risk and address uncertainty employing Monte Carlo simulations for assessing parameter and risk probabilistic distributions. This simulation tool (ERA) includes a Window's based interface, an interactive and modifiable database management system (DBMS) that addresses a food web at trophic levels, and a comprehensive evaluation of exposure pathways. To illustrate this model, ecological risks from depleted uranium (DU) exposure at the US Army Yuma Proving Ground (YPG) and Aberdeen Proving Ground (APG) were assessed and characterized. Probabilistic distributions showed that at YPG, a reduction in plant root weight is considered likely to occur (98% likelihood) from exposure to DU; for most terrestrial animals, likelihood for adverse reproduction effects ranges from 0.1% to 44%. However, for the lesser long-nosed bat, the effects are expected to occur (>99% likelihood) through the reduction in size and weight of offspring. Based on available DU data for the firing range at APG, DU uptake will not likely affect survival of aquatic plants and animals (<0.1% likelihood). Based on field and laboratory studies conducted at APG and YPG on pocket mice, kangaroo rat, white-throated woodrat, deer, and milfoil, body burden concentrations observed fall into the distributions simulated at both sites. PMID:15910910

  12. c-Met inhibitor SU11274 enhances the response of the prostate cancer cell line DU145 to ionizing radiation

    SciTech Connect

    Yu, Hongliang; Li, Xiaoying; Sun, Shaoqian; Gao, Xianshu; Zhou, Demin

    2012-10-26

    Highlights: Black-Right-Pointing-Pointer c-Met inhibition could significantly enhance the radiosensitivity of DU145 cells. Black-Right-Pointing-Pointer The mechanisms of the radiosensitization effect of c-Met inhibition on DU145 cells were also presented in this paper. Black-Right-Pointing-Pointer This is the first study demonstrating the effectiveness of c-Met inhibition on treating HRPC cells with radiotherapy. -- Abstract: Hormone-refractory prostate cancer shows substantial resistance to most conventional therapies including radiotherapy, constitutes a key impediment to curing patients with the disease. c-Met overexpression plays a key role in prostate cancer tumorigenesis and disease progression. Here, we demonstrate that c-Met inhibition by SU11274 could significantly suppress cell survival and proliferation as well as enhance the radiosensitivity of DU145 cells. The underlying mechanisms of the effects of SU11274 on DU145 cells may include the inhibition of c-Met signaling, depolarization of the mitochondrial membrane potential, impairment of DNA repair function, abrogation of cell cycle arrest, and enhancement of cell death. Our study is the first to show the effectiveness of combining c-Met inhibition with ionizing radiation to cure hormone-refractory prostate cancer.

  13. Learning Cultures in Travel and Tourism: A Critique of Manuela du Bois-Reymond's Trendsetter Learner Thesis

    ERIC Educational Resources Information Center

    Morrison, Andrew

    2011-01-01

    This article aims to contribute to the discussion surrounding Manuela du Bois-Reymond's important "trendsetter learner" thesis and, in so doing, to join the wider debate about post-compulsory learning cultures. The article outlines the trendsetter learner thesis and then considers recent criticisms that it has attracted. While the author concurs…

  14. Demonstration Bulletin. Membrane Microfiltration. E. I. DuPont de Nemours and Company, Inc. Oberlin Filter Company

    EPA Science Inventory

    The DuPont/Oberlin microfiltration technology is a physical separation process that removes solid particles from liquid wastes. The process can filter particles that are submicron or larger in diameter. Pretreatment, such as chemical additions, will be required if dissolved con...

  15. E.I. DuPont De Nemours & Company/Oberlin Filter Company Microfiltration Technology. Applications Analysis Report

    EPA Science Inventory

    This report evaluates the DuPont/Oberlin microfiltration technology’s ability to remove metals (present in soluble or insoluble form) and particulates from liquid wastes while producing a dry filter cake and a filtrate that meet applicable disposal requirements. This report also ...

  16. Cytotoxic evaluation of different fractions of Salvia chorassanica Bunge on MCF-7 and DU 145 cell lines

    PubMed Central

    Golshan, Alireza; Amini, Elaheh; Emami, Seyed Ahmad; Asili, Javad; Jalali, Zahra; Sabouri-Rad, Sarvenaz; Sanjar-Mousavi, Naghmeh; Tayarani-Najaran, Zahra

    2016-01-01

    Because of antimicrobial, antioxidant, and anticancer potential, Salvia chorassanica Bunge (Lamiaceae) has been considered as a popular herb in Iranian traditional medicine. Previous studies have shown remarkable cytotoxic properties of the methanol, n-hexane and dichloromethane extract of S. chorassanica on human cervical cancer cells. To seek the therapeutic potentials of S. chorassanica, this study was undertaken to evaluate the cytotoxic activities of various extracts of this plant on human breast MCF-7 and prostate cancer DU 145 cells. The DU 145 cells were exposed to different concentrations of plant extracts (1-200 μg/ml). Cytotoxic activities were examined using alamarBlue® assay and apoptosis was assessed by acridine orange/propodium iodide double staining and evaluation of DNA fragmentation by flow cytometry. Our findings indicated that n-hexane and dichloromethane extracts had more cytotoxic activities against DU 145 and MCF-7 cell lines compared with other extracts (P<0.05). The acridine orange/propodium iodide staining showed apoptogenic properties of n-hexane and dichloromethane extracts which was consequently confirmed by flow cytometric histogram that exhibited an increase in sub-G1 peak in treated cells as compared with untreated cancer cell lines. Taken together, these observations demonstrated cytotoxic effects of S. chorassanica extracts on MCF-7 and DU 145 cell lines which is most likely exerted via apoptosis cell death. Therefore, further investigations on S. chorassanica extracts as potential chemotherapeutic agents are warranted. PMID:27051435

  17. Social Behavior and Characteristics of Autism Spectrum Disorder in Angelman, Cornelia de Lange, and Cri du Chat Syndromes

    ERIC Educational Resources Information Center

    Moss, Joanna; Howlin, Patricia; Hastings, Richard Patrick; Beaumont, Sarah; Griffith, Gemma M.; Petty, Jane; Tunnicliffe, Penny; Yates, Rachel; Villa, Darrelle; Oliver, Chris

    2013-01-01

    We evaluated autism spectrum disorder (ASD) characteristics and social behavior in Angelman (AS; "n" ?=? 19; mean age ?=?10.35 years), Cornelia de Lange (CdLS; "n" ?=? 15; mean age ?=?12.40 years), and Cri du Chat (CdCS, also known as 5 p-syndrome; "n" ?=? 19; mean age ?=? 8.80 years) syndromes. The proportion of…

  18. Lovastatin causes FaDu hypopharyngeal carcinoma cell death via AMPK-p63-survivin signaling cascade

    PubMed Central

    Yen, Chia-Sheng; Chen, Jung-Chien; Chang, Yi-Fang; Hsu, Ya-Fen; Chiu, Pei-Ting; Shiue, Ching; Chuang, Yu-Fan; Ou, George; Hsu, Ming-Jen

    2016-01-01

    Statins are used widely to lower serum cholesterol and the incidence of cardiovascular diseases. Growing evidence shows that statins also exhibit beneficial effects against cancers. In this study, we investigated the molecular mechanisms involved in lovastatin-induced cell death in Fadu hypopharyngeal carcinoma cells. Lovastatin caused cell cycle arrest and apoptosis in FaDu cells. Lovastatin increased p21cip/Waf1 level while the survivin level was decreased in the presence of lovastatin. Survivin siRNA reduced cell viability and induced cell apoptosis in FaDu cells. Lovastatin induced phosphorylation of AMP-activated protein kinase (AMPK), p38 mitogen-activated protein kinase (MAPK) and transcription factor p63. Lovastatin also caused p63 acetylation and increased p63 binding to survivin promoter region in FaDu cells. AMPK-p38MAPK signaling blockade abrogated lovastatin-induced p63 phosphorylation. Lovastatin’s enhancing effect on p63 acetylation was reduced in HDAC3- or HDAC4- transfected cells. Moreover, transfection of cells with AMPK dominant negative mutant (AMPK-DN), HDAC3, HDAC4 or p63 siRNA significantly reduced lovastatin’s effects on p21cip/Waf1 and survivin. Furthermore, lovastatin inhibited subcutaneous FaDu xenografts growth in vivo. Taken together, lovastatin may activate AMPK-p38MAPK-p63-survivin cascade to cause FaDu cell death. This study establishes, at least in part, the signaling cascade by which lovastatin induces hypopharyngeal carcinoma cell death. PMID:27122225

  19. Elaboration du Ge mesoporeux et etude de ses proprietes physico-chimiques en vue d'applications photovoltaiques

    NASA Astrophysics Data System (ADS)

    Tutashkonko, Sergii

    Le sujet de cette these porte sur l'elaboration du nouveau nanomateriau par la gravure electrochimique bipolaire (BEE) --- le Ge mesoporeux et sur l'analyse de ses proprietes physico-chimiques en vue de son utilisation dans des applications photovoltaiques. La formation du Ge mesoporeux par gravure electrochimique a ete precedemment rapportee dans la litterature. Cependant, le verrou technologique important des procedes de fabrication existants consistait a obtenir des couches epaisses (superieure a 500 nm) du Ge mesoporeux a la morphologie parfaitement controlee. En effet, la caracterisation physico-chimique des couches minces est beaucoup plus compliquee et le nombre de leurs applications possibles est fortement limite. Nous avons developpe un modele electrochimique qui decrit les mecanismes principaux de formation des pores ce qui nous a permis de realiser des structures epaisses du Ge mesoporeux (jusqu'au 10 mum) ayant la porosite ajustable dans une large gamme de 15% a 60%. En plus, la formation des nanostructures poreuses aux morphologies variables et bien controlees est desormais devenue possible. Enfin, la maitrise de tous ces parametres a ouvert la voie extremement prometteuse vers la realisation des structures poreuses a multi-couches a base de Ge pour des nombreuses applications innovantes et multidisciplinaires grace a la flexibilite technologique actuelle atteinte. En particulier, dans le cadre de cette these, les couches du Ge mesoporeux ont ete optimisees dans le but de realiser le procede de transfert de couches minces d'une cellule solaire a triple jonctions via une couche sacrificielle en Ge poreux. Mots-cles : Germanium meso-poreux, Gravure electrochimique bipolaire, Electrochimie des semi-conducteurs, Report des couches minces, Cellule photovoltaique

  20. Effect of celecoxib on inhibiting tumor repopulation during radiotherapy in human FaDu squamous cell carcinoma

    PubMed Central

    Yang, Jia; Liu, Jing; Sun, Xin-Dong; Hu, Xu-Dong; Sun, Ju-Jie; Li, Yu-Hui; Yu, Jin-Ming

    2014-01-01

    Aim of the study FaDu human squamous cell carcinoma (FaDu-hSCC) demonstrated accelerated tumor repopulation during fractionated irradiation with pathological validation in a xenograft model system. Previous studies showed that the selective cyclooxygenase (COX)-2 inhibitor celecoxib can enhance the tumor response to radiotherapy. So we aimed to explore the effect of celecoxib in inducing apoptosis and inhibiting repopulation of FaDu tumors in nude mice during fractionated radiotherapy. Material and methods FaDu-hSCC was transplanted into the right hind leg of BALB/C nude mice. Mice were treated with celecoxib and/or fractionated irradiation. Celecoxib (100 mg/kg/day) was administered by daily gavage. Irradiation was delivered with 12 to 18 fractions of 3.0 Gy daily or every second day based on Petersen's repopulation model. At different time points, tumors were excised for immunohistochemistry staining. Results Significant tumor repopulation occurred after about 18 days of radiotherapy. On average, Ki-67 and bromodeoxyuridine (BrdUrd) labeling indices (LI) decreased with daily irradiation (both p < 0.05) and increased with every-second-day irradiation (both p > 0.05), suggesting accelerated repopulation. Ki-67 LI decreased in celecoxib concurrent with radiotherapy for 12 fractions in 24 days and 18 fractions in 36 days compared with irradiated alone (p = 0.004 and 0.042, respectively). BrdUrd LI values were lower in the concurrent groups than irradiated alone (p = 0.001 and 0.006, respectively). Epithelial growth factor receptor (EGFR) expression score decreased in the concurrent groups than irradiated alone (p = 0.037 and 0.031, respectively). Caspase-3 expression scores were higher in the concurrent groups than irradiated alone (p = 0.05 and 0.006, respectively). Conclusions Celecoxib concurrent radiotherapy could inhibit tumor repopulation and increase tumor apoptosis during the treatment in FaDu squamous cell carcinoma. PMID:25258584

  1. Water levels and water-level changes in the Prairie du Chien-Jordan and Mount Simon-Hinckley aquifers, Twin Cities metropolitan area, Minnesota, 1971-80

    USGS Publications Warehouse

    Schoenberg, Michael

    1984-01-01

    Water-level data suggest that (1) little variation in annual pumpage between 1971 and 1980 from the Prairie du Chien-Jordan aquifer produced generally stable water levels in that aquifer, (2) decreased annual pumpage from the Mount Simon-Hinckley aquifer from 1971 to 1980 caused water levels in that aquifer to rise, and (3) a greater seasonal component of pumpage from the Mount Simon-Hinckley aquifer than from the Prairie du Chien-Jordan produced larger and more widespread seasonal water-level declines in the Mount Simon-Hinckley than in the Prairie du Chien-Jordan, particularly during dry years.

  2. Kyste hydatique du foie compliqué d'un accident vasculaire cérébral ischémique: à propos d'un cas

    PubMed Central

    Turki, Olfa; Bahloul, Mabrouk; Chtara, Kamilia; Regaieg, Kais; Haddar, Sondes; Bouaziz, Mounir

    2015-01-01

    Le kyste hydatique du foie (KHF) est une maladie assez répandue dans les pays nord-africains. La rupture post-traumatique ou spontanée du kyste compliquée d'un choc anaphylactique et d'un AVC ischémique a été exceptionnellement rapportée. Nous rapportons un cas d'un kyste hydatique du foie (KHF) fissuré et compliqué d'un choc anaphylactique et d'un AVC ischémique. PMID:26985273

  3. La pubalgie du sportif de haut niveau: place du traitement chirurgical, à propos d'une série continue de 100 cas

    PubMed Central

    Boukhris, Jalal; Mojib, Rifi; Mezghani, Sami; Jaeger, Jean Henri

    2014-01-01

    Parmi tous les syndromes de surmenage liés à la pratique sportive, la pubalgie est certainement un des plus invalidants. C'est un syndrome douloureux de la région inguino-pubienne qui touche particulièrement le joueur du football. Les formes inguino-pariètales sont de loin les plus fréquentes. Le traitement médical est entrepris dans la majorité des cas, mais il semble être moins efficace dans ce sport en particulier. La chirurgie occupe une place prédominante dans la prise en charge. Nous rapportons l'expérience de la prise en charge chirurgicale de 100 sportifs de haut niveau au sein de notre établissement, selon la technique de Nesovic, ainsi que leurs devenirs sportifs et nous discutons nos résultats en se comparant aux données de la littérature récente. PMID:25574333

  4. Caracterisation du coefficient de retrodiffusion radar des surfaces d'hydrocarbure: Modelisation et interpretation

    NASA Astrophysics Data System (ADS)

    Charbonneau, Francois

    La surveillance maritime est un domaine d'applications ou l'interet politique et scientifique croit constamment au Canada. Un des outils privilegies pour la surveillance maritime est l'acquisition de donnees radars, par des systemes aeroportes ou spatio-portes (ERS-2, RADARSAT et Envisat). Par leur grande couverture spatiale, ainsi que leur sensibilite a la geometrie de surface, les donnees radars permettent, en autres, la detection de cibles ponctuelles (bateaux), estimation des vents, detection des glaces de mer, ainsi que la detection de deversement d'hydrocarbure. Les limites et les avantages de la detection d'hydrocarbure par acquisitions de donnees radars sont bien connus, mais il reste encore des lacunes au niveau de l'extraction des parametres physiques d'une surface d'hydrocarbure. Ce projet a pour objectif de caracteriser le coefficient de retrodiffusion radar associe a une surface d'hydrocarbure en milieu oceanique, par l'introduction d'un modele thermodynamique d'attenuation de la surface, au modele theorique radar IEM. Le modele global permet de simuler le comportement de sigma° en fonction des proprietes visco-elastiques, ainsi que de l'epaisseur de la couche d'hydrocarbure et en fonction des parametres d'acquisition radar. Le modele developpe fut valide a partir des donnees SIR-C acquises lors d'experimentations controlees. A partir des informations environnementales et du type d'hydrocarbure, notre modele a permis d'estime le contraste d'intensite avec une precision de 1 a 1,5 dB, a la bande C. Alors qu'a la bande L, l'erreur sur le contraste est d'environ 1,5 a 2 dB sur l'ensemble des mesures. Ce qui est excellant considerant l'heterogeneite des surfaces analysees. Egalement, nous effectuons des analyses multi-polarisees et polarimetriques avec les donnees SIR-C acquises au-dessus de sites experimentaux. II en ressort que le ratio de polarisation VV/HH, ainsi que le facteur d'anisotropie sont des pistes de recherche prometteuses qu'il faudra

  5. Macrofaunal Patterns in and around du Couedic and Bonney Submarine Canyons, South Australia

    PubMed Central

    Dittmann, Sabine; Sorokin, Shirley J.; Hendrycks, Ed

    2015-01-01

    Two South Australian canyons, one shelf-incising (du Couedic) and one slope-limited (Bonney) were compared for macrofaunal patterns on the shelf and slope that spanned three water masses. It was hypothesized that community structure would (H1) significantly differ by water mass, (H2) show significant regional differences and (H3) differ significantly between interior and exterior of each canyon. Five hundred and thirty-one species of macrofauna ≥1 mm were captured at 27 stations situated in depth stratified transects inside and outside the canyons from 100 to1500 m depth. The macrofauna showed a positive relationship to depth in abundance, biomass, species richness and community composition while taxonomic distinctness and evenness remained high at all depths. Biotic variation on the shelf was best defined by variation in bottom water primary production while sediment characteristics and bottom water oxygen, temperature and nutrients defined biotic variation at greater depth. Community structure differed significantly (p<0.01) among the three water masses (shelf-flowing South Australian current, upper slope Flinders current and lower slope Antarctic Intermediate Water) (H1). Although community differences between the du Couedic and Bonney regions were marginally above significance at p = 0.05 (H2), over half of the species captured were unique to each region. This supports the evidence from fish and megafaunal distributions that the du Couedic and Bonney areas are in different bioregions. Overall, the canyon interiors were not significantly different in community composition from the exterior (H3). However, both canyons had higher abundance and/or biomass, increased species dominance, different species composition and coarser sediments near the canyon heads compared to outside the canyons at the same depth (500 m), suggestive of heightened currents within the canyons that influence community composition there. At 1000–1500 m, the canyon interiors were

  6. Dérives thermiques du capteur de pression capacitif microélectronique

    NASA Astrophysics Data System (ADS)

    Ettouhami, A.; Essaid, A.; Ouakrim, N.; Michel, L.; Limouri, M.

    1997-07-01

    The thermal drifts of microelectronic capacitive pressure sensor have been analysed by finite-element method. Various boundary conditions representing a wide gamut of support of sensor have been considered: sensor with free base, sensor with fixed base and sensor attached to a support of alumina. For every case, the thermal response of sensor have been determined as a function of sensor dimensions in order to push far the buckling temperature and hence reduce the thermal sensitivity. For some sensors very sensitive to pressure, this temperature is small and the thermal drifts are important. A sensor with fixed base having a diaphragm of 1000 μm of radius and 12 μm of thickness and having a 3.5 μm of plate separation presents a thermal sensitivity of -200 Pa °C^{-1} above 80 ^circC. A sensor attached to a support of alumina, having a more wide diaphragm (1800 μm of radius) presents a thermal sensitivity of 3.1 Pa °C^{-1} below -100 ^circC. Les dérives thermiques du capteur de pression capacitif microélectronique sont analysées par la méthode des éléments finis. Différentes conditions aux limites représentant une large gamme de support de capteur ont été envisagées : capteur à base libre, capteur à base fixe et capteur collé à un support d'alumine. Dans chaque cas, la réponse thermique du capteur a été déterminée en fonction des dimensions du capteur afin de repousser la température de flambage et réduire en conséquence la sensibilité thermique. Pour certains capteurs très sensibles à la pression, cette température est très faible et les dérives thermiques sont importantes. Ainsi un capteur à base fixe (membrane de rayon 1000 μm, et épaisseur 12 μm, distance entre armatures 3,5 μm) présente une sensibilité thermique de -200 Pa °C^{-1} au-dessus de 80 ^circC. Un capteur collé à un support d'alumine, de membrane plus large (rayon 1800 μm) possède une sensibilité thermique de 3,1 Pa °C^{-1} au-dessous de -100 ^circC.

  7. Flood-inundation maps for the DuPage River from Plainfield to Shorewood, Illinois, 2013

    USGS Publications Warehouse

    Murphy, Elizabeth A.; Sharpe, Jennifer B.

    2013-01-01

    Digital flood-inundation maps for a 15.5-mi reach of the DuPage River from Plainfield to Shorewood, Illinois, were created by the U.S. Geological Survey (USGS) in cooperation with the Will County Stormwater Management Planning Committee. The inundation maps, which can be accessed through the USGS Flood Inundation Mapping Science Web site at http://water.usgs.gov/osw/flood_inundation/ depict estimates of the areal extent of flooding corresponding to selected water levels (gage heights or stages) at the USGS streamgage at DuPage River at Shorewood, Illinois (sta. no. 05540500). Current conditions at the USGS streamgage may be obtained on the Internet at http://waterdata.usgs.gov/usa/nwis/uv?05540500. In addition, the information has been provided to the National Weather Service (NWS) for incorporation into their Advanced Hydrologic Prediction Service (AHPS) flood warning system (http://water.weather.gov/ahps/). The NWS forecasts flood hydrographs at many places that are often colocated with USGS streamgages. The NWS-forecasted peak-stage information, also shown on the DuPage River at Shorewood inundation Web site, may be used in conjunction with the maps developed in this study to show predicted areas of flood inundation. In this study, flood profiles were computed for the stream reach by means of a one-dimensional step-backwater model. The hydraulic model was then used to determine nine water-surface profiles for flood stages at 1-ft intervals referenced to the streamgage datum and ranging from NWS Action stage of 6 ft to the historic crest of 14.0 ft. The simulated water-surface profiles were then combined with a Digital Elevation Model (DEM) (derived from Light Detection And Ranging (LiDAR) data) by using a Geographic Information System (GIS) in order to delineate the area flooded at each water level. These maps, along with information on the Internet regarding current gage height from USGS streamgages and forecasted stream stages from the NWS, provide emergency

  8. The identification of five novel genes in the cri-du-chat critical region

    SciTech Connect

    Simmons, A.D.; Gallardo, T.D.; Lovett, M.

    1994-09-01

    Cri-du-chat is a contiguous gene syndrome associated with deletions in the short arm of chromosome 5 (chr 5). Chr 5p-specific markers have been used to define two critical regions: a larynx malformation region, located at 5p15.3, and a region responsible for the remaining clinical features of the syndrome, which maps to 5p15.2. Thirty cosmids that map to this latter region have been isolated from the LANL chr 5-specific library using 5 STSs. More recently, we have constructed a YAC contig of the region which encompasses 2-3 Mb. The 30 framework cosmids were used in a direct selection with cDNAs from placenta, activated T-cells and cerebellum to isolate an initial set of expressed sequences from this region. Since no genes, to date, have been isolated or localized within the cri-du-chat deletion, a cosmid containing a control reporter gene (ANX6) was used to monitor enrichment. ANX6 cDNAs were enriched by several thousand-fold in the selected cDNAs. A total of nine non overlapping cDNA fragments were obtained from the cDNA pools. These have been ordered within the YAC contig, map to 5 discrete cosmid sets in the critical region and thus conservatively represent five discrete transcription units. The DNA sequences of these fragments are novel by sequence database comparisons. PCR primers were constructed and were used to confirm gene placements in the YAC contig, as well as to investigate the expression profile of these genes in several different tissues and cell types. In one case, these primer sets enabled two of the nine fragments to be linked into a larger cDNA. The nine cDNAs showed various patterns of differential expression in a panel of tissues. These expressed sequences represent the first genes isolated within the cri-du-chat critical region and represent the initial steps in the derivation of a comprehensive inventory and expression profile of the estimated 100 genes that may reside in this region.

  9. Macrofaunal Patterns in and around du Couedic and Bonney Submarine Canyons, South Australia.

    PubMed

    Conlan, Kathleen E; Currie, David R; Dittmann, Sabine; Sorokin, Shirley J; Hendrycks, Ed

    2015-01-01

    Two South Australian canyons, one shelf-incising (du Couedic) and one slope-limited (Bonney) were compared for macrofaunal patterns on the shelf and slope that spanned three water masses. It was hypothesized that community structure would (H1) significantly differ by water mass, (H2) show significant regional differences and (H3) differ significantly between interior and exterior of each canyon. Five hundred and thirty-one species of macrofauna ≥ 1 mm were captured at 27 stations situated in depth stratified transects inside and outside the canyons from 100 to 1500 m depth. The macrofauna showed a positive relationship to depth in abundance, biomass, species richness and community composition while taxonomic distinctness and evenness remained high at all depths. Biotic variation on the shelf was best defined by variation in bottom water primary production while sediment characteristics and bottom water oxygen, temperature and nutrients defined biotic variation at greater depth. Community structure differed significantly (p<0.01) among the three water masses (shelf-flowing South Australian current, upper slope Flinders current and lower slope Antarctic Intermediate Water) (H1). Although community differences between the du Couedic and Bonney regions were marginally above significance at p = 0.05 (H2), over half of the species captured were unique to each region. This supports the evidence from fish and megafaunal distributions that the du Couedic and Bonney areas are in different bioregions. Overall, the canyon interiors were not significantly different in community composition from the exterior (H3). However, both canyons had higher abundance and/or biomass, increased species dominance, different species composition and coarser sediments near the canyon heads compared to outside the canyons at the same depth (500 m), suggestive of heightened currents within the canyons that influence community composition there. At 1000-1500 m, the canyon interiors were

  10. Hématome spontané du méso de l'angle colique droit et du colon transverse compliquant un traitement par anti vitamine K: à propos d'un cas et revue de la littérature

    PubMed Central

    Traoré, Ibrahim Alain; Zaré, Cyprien; Barro, Sié Drissa; Guibla, Ismaël

    2016-01-01

    L'hématome spontané du méso de l'angle colique droit et du transverse est une complication rare du traitement anticoagulant par antivitamine K. Nous rapportons un cas d'hématome spontané du méso de l'angle colique droit et du transverse associé à un hémopéritoine de grande abondance chez un patient traité par antivitamine K pour embolie pulmonaire consécutive à une fracture des plateaux tibiaux droits. Le diagnostic doit être fait en urgence. L’échographie abdominale et la tomodensitométrie confirment le diagnostic. Le traitement non opératoire est la règle. Le traitement chirurgical est indiqué en cas de complications telles que la rupture de l'hématome. PMID:27217878

  11. A new aldehyde compound from the fruit of Pandanus tectorius Parkinson ex Du Roi.

    PubMed

    Mai, Dinh Tri; Le, Tien Dung; Nguyen, Tan Phat; Phan, Nhat Minh; Nguyen, Huu An; Nguyen, Thi Thanh Phuc; Tran, Le Quan

    2015-01-01

    From the fruit of Pandanus tectorius Parkinson ex Du Roi, one new (1) and six known aldehyde compounds (2-7) were isolated by various chromatography methods. Based on their spectroscopic data, these compounds were identified as (Z)-4-hydroxy-3-(4-hydroxy-3-methylbut-2-en-1-yl) benzaldehyde (1), p-hydroxybenzaldehyde (2), syringaldehyde (3), (E)-ferulaldehyde (4), (E)-sinapinaldehyde (5), vanillin (6) and 5-hydroxymethylfurfual (7). The α-glucosidase inhibitory activity of all compounds was measured. The isolated compounds (1-6) showed better α-glucosidase inhibitory activity (IC50 values ranging from 36.5 to 192.4 μM) than the standard drug acarbose (IC50 = 214.5 μM). PMID:25674660

  12. Queue observing at the Observatoire du Mont-Mégantic 1.6-m telescope

    NASA Astrophysics Data System (ADS)

    Artigau, Étienne; Lamontagne, Robert; Doyon, René; Malo, Lison

    2010-07-01

    Queue planning of observation and service observing are generally seen as specific to large, world-class, astronomical observatories that draw proposal from a large community. One of the common grievance, justified or not, against queue planning and service observing is the fear of training a generation of astronomers without hands-on observing experience. At the Observatoire du Mont-Mégantic (OMM) 1.6-m telescope, we are developing a student-run service observing program. Queue planning and service observing are used as training tools to expose students to a variety of scientific project and instruments beyond what they would normally use for their own research project. The queue mode at the OMM specifically targets relatively shallow observations that can be completed in less than a few hours and are too short to justify a multi-night classical observing run.

  13. The focal plane adaptive optics test box of the Observatoire du Mont-Mégantic

    NASA Astrophysics Data System (ADS)

    Deschênes, William; Brousseau, Denis; Lavigne, Jean-Francois; Thibault, Simon; Véran, Jean-Pierre

    2014-08-01

    With the upcoming construction of Extremely Large Telescopes, several existing technologies are being pushed beyond their performance limit and it becomes essential to develop and evaluate new alternatives. The "Observatoire du Mont Mégantic" (OMM) hosts a telescope having a 1.6-meter diameter primary. The OMM telescope is known to be an excellent location to develop and test precursor instruments which are then upscaled to larger telescopes (ex. SPIOMM which led to SITELLE at the CFHT). We present a specifically designed focal plane box for the OMM which will allow to evaluate, directly on-sky, the performance of a number of next generation adaptive optics related technologies The system will able us to compare the performance of several new wavefront sensors in contrast with the current standard, the Shack-Hartman wavefront sensor.

  14. Screening for bladder cancer at the Du Pont Chambers Works: initial findings

    SciTech Connect

    Mason, T.J.; Prorok, P.C.; Neeld, W.E. Jr.; Vogler, W.J.

    1986-10-01

    The following data have been abstracted on all persons ever screened for bladder cancer and on all persons known to have developed bladder cancer among the Chambers Works employees, regardless of whether they had been screened: complete work histories, including dates of employment by job title and location for the duration of employment by Du Pont; medical histories, including the dates and results of every urinary cytological reading and urinary blood test, and the dates and type of every physical examination; and vital status information, including data from death certificates. For each bladder cancer case, detailed clinical histories were abstracted to provide information concerning signs or symptoms of bladder cancer, procedures performed, findings, and recommendations. Pathological information includes type, grade, stage, evidence of multicentricity, metastatic sites, and second primary sites of malignancy. Data are being edited and subjected to preliminary analysis.

  15. An analysis of the DuPage County Regional Office of Education physics exam

    NASA Astrophysics Data System (ADS)

    Muehsler, Hans

    In 2009, the DuPage County Regional Office of Education (ROE) tasked volunteer physics teachers with creating a basic skills physics exam reflecting what the participants valued and shared in common across curricula. Mechanics, electricity & magnetism (E&M), and wave phenomena emerged as the primary constructs. The resulting exam was intended for first-exposure physics students. The most recently completed version was psychometrically assessed for unidimensionality within the constructs using a robust WLS structural equation model and for reliability. An item analysis using a 3-PL IRT model was performed on the mechanics items and a 2-PL IRT model was performed on the E&M and waves items; a distractor analysis was also performed on all items. Lastly, differential item functioning (DIF) and differential test functioning (DTF) analyses, using the Mantel-Haenszel procedure, were performed using gender, ethnicity, year in school, ELL, physics level, and math level as groupings.

  16. Characterization of DuPont photopolymer: determination of kinetic parameters in a diffusion model

    NASA Astrophysics Data System (ADS)

    Moreau, Vincent; Renotte, Yvon; Lion, Yves

    2002-06-01

    We investigate the recording dynamics of Omnidex photopolymer film from DuPont. We use a reviewed version of the diffusion model proposed by Zhao and Mouroulis [J. Mod. Opt. 41, 1929 (1994)] in order to describe the recording response that combined photopolymerization and free-monomer diffusion process. Two different experiments are detailed that lead to the determination of material kinetic parameters. These values are introduced in the numerical model to provide quantitative simulations of a grating formation under various holographic exposures. Theoretical results are experimentally checked as a validation of the model. We extend its applications to several secondary investigations, such as volume-shrinkage influence on refractive-index distribution and spectral selectivity of reflection gratings. This study improves the understanding of the recording process and consequently allows to build more accurate holographic components in this material to be built.

  17. Thrombophlébite cérébrale inhabituelle du post-partum

    PubMed Central

    El Hassani, Moulay Elmehdi; Habib, Abdellah Baba; Kouach, Jaouad; Sekkach, Youssef; Bakkali, Hicham; Jira, Mohamed; Elqatni, Mohamed; Abouzahir, Ali; Ghafir, Dris; Moussaoui, Dris; Dehayni, Mohamed

    2014-01-01

    La thrombophlébite cérébrale du post-partum immédiat constitue un événement rare et gravissime pouvant mettre en jeu le pronostic vital à court terme. Celle-ci doit être systématiquement évoquée devant la persistance d'une fièvre dans les suites de couches. La prise en charge associera le plus souvent, des antibiotiques à large spectre et des anticoagulants. Le suivi évolutif est indispensable, afin d'apprécier l'efficacité thérapeutique. A travers une observation singulière et à présentation inhabituelle, nous insistons sur le grand intérêt des moyens d'imagerie dont nous disposons afin de porter le diagnostic et de choisir le traitement le mieux adapté. PMID:25478039

  18. Arrêt cardiaque au cours d'une chirurgie de kyste hydatique du foie

    PubMed Central

    Ouzzad, Omar; Kechna, Hicham; Moudden, Mohamed Karim; Chkoura, Khalid; Hanafi, Sidi Mohamed

    2015-01-01

    L'hydatidose est une pathologie fréquente qui reste encore endémique au Maroc. Sa localisation privilégiée est le foie. Son traitement repose essentiellement sur la chirurgie. Celui-ci est parfois incriminé dans la survenue de réactions allergiques sévères pouvant menacer le pronostic vital. Nous rapportons un nouveau cas de réaction anaphylactique sévère de grade IV peropératoire au cours d'une chirurgie de kystes hydatiques multiples du foie. Nous insistons sur la nécessité de sa reconnaissance rapide afin d'instaurer rapidement un traitement efficace. La prévention de cet accident est basée sur des précautions chirurgicales pour éviter les fuites ou les ruptures accidentelles peropératoires des kystes hydatiques. PMID:26664533

  19. Protein-energy malnutrition is frequent and precocious in children with cri du chat syndrome.

    PubMed

    Lefranc, Violaine; de Luca, Arnaud; Hankard, Régis

    2016-05-01

    Protein-energy malnutrition (PEM) is poorly reported in cri du chat syndrome (CDCS) (OMIM #123450), a genetic disease that causes developmental delay and global growth retardation. The objective was to determine the nutritional status at different ages in children with CDCS and factors associated with PEM. A questionnaire focused on growth and nutritional care was sent to 190 families. Among 36 analyzable questionnaires, growth and nutritional indices compatible with PEM occurred in 47% of patients: 19% before 6 months of age, 24% between 6-12 months and 34% after 12 months. Eight patients received enteral feeding. Speech therapy for swallowing education was performed more often in malnourished children (63% vs. 22%, P < 0.02). PEM is frequent and occurs early in this disease, requiring closed nutritional monitoring. © 2016 Wiley Periodicals, Inc. PMID:26872355

  20. Cognitive functioning in children with typical cri du chat (5p-) syndrome.

    PubMed

    Cornish, K M; Bramble, D; Munir, F; Pigram, J

    1999-04-01

    This study is the first attempt to assess systematically the cognitive functioning in children diagnosed with typical cri du chat syndrome (CDCS) using neuropsychological test measures. Twenty-six children aged between 6 years 4 months and 15 years 5 months (mean 8 years 3 months) completed a battery of tasks measuring IQ level, receptive and expressive language skills, and articulation. Twenty-four children were in the severe learning-disability range with no specific verbal or performance profile. Using more finely tuned measures of cognition, however, a clear discrepancy in the pattern of language functioning was found with better receptive than expressive language skills. One implication of these findings is that parents and professionals should be more optimistic about the capacities of children with CDCS to understand more complex verbal commands than their expressive language skills would suggest. PMID:10355811

  1. Diagnostic et prévalence du syndrome métabolique chez les diabétiques suivis dans un contexte de ressources limitées: cas du Burkina-Faso

    PubMed Central

    Marceline, Yaméogo Téné; Issiaka, Sombié; Gilberte, Kyélem Carole; Nadège, Rouamba; Macaire, Ouédraogo Sampawindé; Arsène, Yaméogo Aimé; Djingri, Lankoandé; Apollinaire, Sawadogo; Joseph, Drabo Youssouf

    2014-01-01

    Introduction Les conséquences du syndrome métabolique impliquent son diagnostic effectif pour une prise en charge globale des comorbidités dépistées. Objectif: Déterminer la capacité à diagnostiquer le syndrome métabolique en routine, sa prévalence chez les diabétiques, leurs connaissances et pratiques vis-à-vis du risque cardio-métabolique. Méthodes Il s'est agi d'une étude transversale auprès de 388 diabétiques au CHU de Bobo-Dioulasso. Les critères de la fédération internationale du diabète (2009) ont été utilisés. Résultats l’âge moyen était de 53,5±13,5 ans, le sex ratio de 0,7. L'obésité abdominale était présente dans 61,9% des cas; L'HTA l’était dans 56,4% des cas. La prescription du bilan lipidique a été documentée dans 55,4% des cas pour le HDL et 56,2% pour les triglycérides pour un taux de réalisation de 49,3% et 62,9%. Le taux de dépistage des critères lipidiques était de 26,8%. Un taux de HDL bas a été noté dans 46 cas (43,4%) et une hypertriglycéridémie dans 24 cas (17,6%). In fine, la prévalence du syndrome métabolique était de 48,9% (n = 190). Seuls 27,4% savaient que d'autres facteurs de risque cardiovasculaire pouvaient être associés au diabète et seulement 6,7% pratiquaient une activité physique régulière. Conclusion Malgré la faible contribution du laboratoire, le syndrome métabolique est fréquent parmi nos diabétiques. Les patients sont peu sensibilisés sur le risque vasculaire et la pratique d'une activité physique régulière reste faible. Un programme d’éducation adaptée contribuerait à un meilleur dépistage et à une prise en charge optimale des cas. PMID:25932077

  2. Faible taux de succès du sevrage tabagique à court et moyen termes au décours d'un infarctus aigu du myocarde dans un service de cardiologie de Dakar au Sénégal

    PubMed Central

    Mbaye, Alassane; Diop, Adja Mariétou; Dioum, Momar; Bodian, Malick; Ndiaye, Mouhamadou Bamba; Kane, Adama; Yaméogo, Nobila Valentin; Diao, Maboury; Ba, Oumar; Kane, Abdoul

    2011-01-01

    Introduction Le tabagisme est un puissant facteur de risque cardio-vasculaire. Son sevrage semble moins bien pris en compte chez les coronariens. Les objectifs de ce travail étaient d’évaluer la prévalence du tabagisme et le sevrage tabagique au décours d'un infarctus du myocarde dans un service de cardiologie au Sénégal. Méthodes Il s'agit d'une étude transversale et descriptive réalisée entre janvier 2008 et juin 2010. Nous avons recruté les patients hospitalisés pour infarctus du myocarde puis les fumeurs actifs ont été inclus dans notre enquête. Les malades étaient sensibilisés pour l'arrêt du tabac puis suivis à 3 mois, 6 mois et 12 mois pour évaluer le sevrage tabagique. Résultats Nous avons recensé 82 patients hospitalisés pour un infarctus du myocarde, parmi eux 26 sujets (25 hommes) étaient fumeurs (31,7%). L’âge moyen des sujets fumeurs était de 56±11,5 ans. La consommation moyenne de tabac était de 32±14 paquets-année et le score moyen de Fagerström de 8. Tous les patients ont arrêté le tabac pendant l'hospitalisation. Après un suivi de 3 mois, 45% des patients ont repris le tabac, 65% à 6 mois et 85% à 12 mois. Conclusion Le tabagisme est assez fréquent chez les patients sénégalais présentant un infarctus du myocarde. Le taux de sevrage tabagique à court et moyen termes est faible. Le sevrage tabagique devrait alors constituer un objectif privilégié dans la prévention des maladies cardio-vasculaires. PMID:22187601

  3. La physique à l'échelle du TeV

    NASA Astrophysics Data System (ADS)

    Chiappetta, P.

    We first stress that very energetic hadronic colliders (LHC/SSC) have to be built in order to clarify the mechanism of electroweak symmetry breaking. We show that discovery of a fundamental Higgs scalar is possible in the range 130 ≤ MH ≤ 800 GeV and the importance of an e+e- collider to discover a Higgs in the range 90 < MH ≤ 200 GeV. Then we will discuss the potentialities of LHC/SSC for discovery of supersymmetric partners up to the crucial TeV scale. Ways to find a strongly interacting Higgs sector (without existence of a fundamental Higgs) are finally given. On souligne tout d'abord la nécessité de construire des accélérateurs hadroniques (LHC/SSC) très énergétiques pour clarifier le mécanisme de brisure de la symétrie électrofaible. On montre que la découverte d'un scalaire de Higgs fondamental est possible dans le domaine 130 ≤ M H ≤ 800 GeV et l'intérêt d'un collisionneur e+e - pour observer un Higgs dans le domaine 90 GeV ≤ M H ≤ 200 GeV On passera ensuite en revue les potentialités du LHC/SSC concernant la découverte de partenaires supersymétriques jusqu'à l'échelle cruciale du TeV Les moyens d'observer un secteur de Higgs fortement interagissant (cas où un Higgs fondamental n'existe pas) sont enfin indiqués.

  4. Prescrire du cannabis fumé pour la douleur chronique non cancéreuse

    PubMed Central

    Kahan, Meldon; Srivastava, Anita; Spithoff, Sheryl; Bromley, Lisa

    2014-01-01

    Résumé Objectif Offrir des conseils préliminaires sur la prescription de cannabis fumé pour la douleur chronique avant la publication de lignes directrices officielles. Qualité des données Nous avons examiné les ouvrages scientifiques sur l’efficacité analgésique du cannabis fumé et les dommages causés par la consommation de cannabis à des fins médicales et récréatives. Nous avons élaboré des recommandations concernant les indications et les contre-indications du cannabis fumé, les précautions à prendre et son dosage et nous avons classé les recommandations en fonction du niveau des données probantes. La plupart des données probantes sont de niveau II (études observationnelles bien effectuées) et de niveau III (opinion d’experts). Message principal Le cannabis fumé pourrait être indiqué chez des patients souffrant de douleurs neuropathiques sévères qui n’ont pas répondu à des essais suffisants de cannabinoïdes pharmaceutiques et d’analgésiques standards (données probantes de niveau II). Le cannabis fumé est contre-indiqué chez les patients de 25 ans ou moins (données probantes de niveau II); ceux qui font actuellement ou ont fait par le passé une psychose ou encore ont de forts antécédents familiaux de psychose (données probantes de niveau II); ceux qui ont ou ont eu un problème de consommation de cannabis (données probantes de niveau III); ceux qui ont un problème actuel de toxicomanie ou d’alcoolisme (données probantes de niveau III); ceux qui ont une maladie cardiovasculaire ou respiratoire (données probantes de niveau III); ou celles qui sont enceintes ou planifient une grossesse (données probantes de niveau II). Il devrait être utilisé avec précaution par les patients qui fument du tabac (données probantes de niveau II), qui sont à risque accru de maladies cardiovasculaires (données probantes de niveau III), qui ont des troubles d’anxiété ou de l’humeur (données probantes de niveau II) ou

  5. Est-ce que le fumeur connaît les méfaits du tabac?

    PubMed Central

    Janah, Hicham; Elouazzani, Hanane; Souhi, Hicham; Naji-Amrani, Hicham; Zegmout, Adil; Rhorfi, Ismail Abderrahmani; Abid, Ahmed

    2014-01-01

    Le tabagisme est une des principales causes de morbidité et de mortalité évitable. Le but de ce travail est d’évaluer les connaissances du fumeur vis-à-vis les risques du tabac et son motivation pour cesser de fumer. Nous avons réalisé une enquête transversale chez les malades tabagiques hospitalisés au service en répondant à un questionnaire précisant leur niveau socio-économique et culturel, l'histoire du tabagisme, les méfaits connus du tabac, la dépendance pharmacologique à la nicotine et leur motivation pour cesser de fumer. Il s'agit de 120 patients, l’âge moyen était de 45 ans±15. Les principaux motifs d'hospitalisation étaient: pathologie tumorale (54%), pathologie infectieuse (35%) BPCO (9%). 85% des patients étaient scolarisés jusqu'au cycle secondaire. Pour l'ensemble des patients, l’âge moyen de la première cigarette était précoce (avant de 20 ans) et la dépendance pharmacologique à la nicotine était légère (82% avaient un score de Fagerström < 8). Plus d'un tiers des patients (38%) avaient au moins fait une tentative d'arrêt. La connaissance des effets néfastes du tabac était variable: les pathologies cancéreuses (88%), les maladies cardiovasculaires (65%) et la BPCO (31%). La majorité des patients (78%) avaient cessé de fumer depuis l'hospitalisation. Notre enquête met en évidence l'intérêt de la médiatisation dans l'information de la population sur les risques du tabac. Les pneumologues, qui prennent en charge la grande majorité de ces patients, doivent donc s'impliquer activement dans ce domaine. PMID:25745534

  6. Etude du comportement et de la modélisation viscoplastique du zircaloy 4recristallisé sous chargements monotones et cycliques uni et multiaxes

    NASA Astrophysics Data System (ADS)

    Delobelle, P.; Robinet, P.

    1994-08-01

    à la température ambiante ainsi que l'indépendance du rapport R^p = \\varepsilon^p_{θθ}/\\varepsilon^ p_{{^-_-}{^-_-} } avec la température laissent supposer que l'ensemble des coefficients d'anisotropie ne dépendent pas de la température. Par contre, la fluidité de cet alliage présente un minimum très marqué au voisinage de 300 ^{circ}C. Ce comportement est imputable au vieillissement dynamique fréquemment observé dans les solutions solides d'insertion. Lors d'un chargement cyclique hors phase (traction-torsion déphasée à 90^{circ}) ce matériau présente un léger durcissement supplémentaire. On propose l'extension au cas du zircaloy 4 de la formulation d'un modèle viscoplastique unifié développé et identifié par ailleurs sur d'autres matériaux initialement isotropes. D'une manière générale, l'introduction de l'anisotropie dans ce modèle s'effectue par l'intermédiaire de quatre tenseurs d'ordre 4 affectant les directions d'écoulement [ M] , les parties linéaires des écrouissages cinématiques [ N] , ainsi que les restaurations dynamiques [ Q] et statiques [ R] de ces mêmes variables d'écrouissage. L'identification de ce modèle est discutée et réalisée à 350 ^{circ}C. On montre l'adéquation du formalisme à appréhender l'ensemble des caractéristiques mécaniques de cet alliage.

  7. La place de l'imagerie par résonance magnétique dans le carcinome lobulaire du sein

    PubMed Central

    Bouzoubaa, Wail; Laadioui, Meryem; Alaoui, Fatime Zahra Fdili; Jayi, Sofia; Bouguern, Hakima; Chaara, Hikmat; Melhouf, Moulay Abdelilah

    2014-01-01

    Le carcinome lobulaire reste une entité histologique peu fréquente du cancer du sein, toute fois la place qu'occupe le cancer du sein actuellement dans la cancérologie féminine, justifie la connaissance des particularités de ce type de cancer mammaire. Le diagnostic paraclinique est basée sur le couple écho-mammographie a la recherche de multifocalité, multicentricité ou bilatéralité, d'où l'intérêt de l'IRM qui est la technique la plus sensible pour la mise en évidence de ces lésions et qui est devenue un examen de pratique courante dans le carcinome lobulaire du sein. Par le présent travail, et sous la lumière de la revue de la littérature, nous allons essayer de dégager les aspects épidémiologiques, cliniques, et paracliniques, du carcinome lobulaire du sein, et insister sur les indications et l'intérêt de l'IRM dans la prise en charge de ce type histologique. PMID:25368710

  8. La Greffe de Peau dans le Traitement des Sequelles de la Main Brulee. A Propos de 152 Cas - Experience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc

    PubMed Central

    El Mazouz, S.; Fejjal, N.; Hafidi, J.; Cherkab, L.; Mejjati, H.; Belfqih, R.; Gharib, N.; Abbassi, A.

    2010-01-01

    Summary La main est fréquemment exposée aux brûlures, entraînant des séquelles esthétiques et fonctionnelles. Le traitement de ces séquelles est surtout chirurgical et consiste en la greffe de peau, dont le type dépend de la localisation de la brûlure et du type des séquelles. Dans ce travail rétrospectif, nous rapportons une série de 152 cas de brûlures des mains colligés au service de chirurgie plastique du Centre Hospitalier Universitaire Ibn-Sina de Rabat sur une période de dix ans, allant de 1998 à 2007. Les indications thérapeutiques dépendent du type de séquelles et de la localisation de la brûlure. En tout, 97 patients ont bénéficié d'une greffe cutanée, dont 76% par greffe de peau totale, 21% par greffe de peau demi-épaisse et 3% par peau fine. Les séquelles des brûlures des mains posent un problème thérapeutique majeur, malgré la diversité des procédés chirurgicaux, d'où l'intérêt de la prévention. PMID:21991196

  9. Sarcome à cellules claires du rein : À propos d’un cas chez un jeune de 17 ans

    PubMed Central

    Mazdar, Adil; Sakel, Adil Ait; Essatara, Younes; Beddouche, Ali; Elsayegh, Hachem; Iken, Ali; Benslimane, Lounis; Nouini, Yassine

    2014-01-01

    Résumé Le sarcome à cellules claires du rein (SCCR) se voit très rarement chez les jeunes. Il est caractérisé par une évolution agressive marquée par un taux élevé de récidive et de mortalité. Nous rapportons le cas d’un SCCR chez un patient de 17 ans et nous discutons de son apport et de son intérêt médical en vue d’une bonne prise en charge thérapeutique. L’agressivité du SCCR et la prolifération de métastases surtout osseuses impliquent qu’il ne faut pas méconnaître ce diagnostic afin de mettre en place un traitement adapté. PMID:24940474

  10. DuSable High School Internet Project and its influence in connecting Chicago Public Schools to the Internet

    NASA Astrophysics Data System (ADS)

    York, D. G.; Mac Low, M. M.; Brown, B.; Franco, L. M.; Rebull, L. M.; Graziani, C.; Lauroesch, J.

    1998-05-01

    Jean Baptiste Point DuSable High School is a public school in inner city Chicago with a 100% African American student population, over 90% of which live below the poverty limit. In 1995, in partnership with the University of Chicago they applied to NASA's IDEAS program for seed money to bring the Internet to the school via a dedicated T1 connection. We will present the detailed successes and failures of this project. While several aspects did not work out as well as expected, in the long term the project did provide important guidance for a more sucessful involvement in 12 additional public schools in the same social situation. In these more recent involvements we have been able to provide more consistent and continued support than was possible at DuSable High School.

  11. Benchmark of Lower Hybrid coupling codes (Brambilla, GRILL3D-U, TOPLHA) with the FTU conventional grill experimental data

    NASA Astrophysics Data System (ADS)

    Ceccuzzi, Silvio; Maggiora, Riccardo; Milanesio, Daniele; Mirizzi, Francesco; Panaccione, Luigi

    2011-12-01

    The present work compares and experimentally validates the results coming out from the following three Lower Hybrid (LH) coupling codes: Brambilla code (M. Brambilla), GRILL3D-U (Mikhail Irzak, A. F. Ioffe Physico-Technical Institute, Russia) and TOPLHA (Politecnico di Torino, Italy). The conventional grill antenna, operating in FTU in different scenarios, is used as benchmark. The validation with experimental data is carried out with respect to the average reflection coefficients at the input of a row of the grill, considering two different phasings between adjacent waveguides: -90 ° and -75 °. A comparison between calculated power spectra is also presented. Good agreement can be observed for all the simulated plasma profiles and waveguide phasings between experimental data and codes, in particular for the most recent numerical tools, namely GRILL3D-U and TOPLHA.

  12. The metabolism of DuP 753, a nonpeptide angiotensin II receptor antagonist, by rat, monkey, and human liver slices.

    PubMed

    Stearns, R A; Miller, R R; Doss, G A; Chakravarty, P K; Rosegay, A; Gatto, G J; Chiu, S H

    1992-01-01

    The in vitro metabolism of DuP 753, a novel nonpeptide angiotensin II receptor antagonist, has been investigated in incubations with liver slice preparations from rats, monkeys and humans. Metabolites were identified by HPLC/MS, FAB/MS, Cl/MS, and/or 1H NMR. In the rat, the primary route of metabolism was oxidative, leading to either monohydroxylated or oxidized (carboxylic acid) metabolites, whereas in monkeys, glucuronidation of the tetrazole moiety predominated. An equal mixture of both oxidized and glucuronic acid-conjugated metabolites was isolated from incubations with human liver slices. All metabolites were tested in an in vitro assay to determine their activity as angiotensin II receptor antagonists. The monohydroxylated products and glucuronic acid conjugates were determined to be much less active than DuP 753. Biotransformation to the carboxylic acid, however, was shown to dramatically increase the activity of this agent. The in vivo duration of action of DuP 753 has been observed to be much longer in the rat than in the monkey. This may be explained, at least in part, by these in vitro metabolism studies. The predominance of glucuronidation observed in incubations with monkey liver slices would yield metabolites with diminished activity and might be expected to shorten the in vivo duration of DuP 753 in that species. The oxidative conversion to the carboxylic acid metabolite, along with the low level of glucuronidation observed in incubations with rat liver slices, may be responsible for the prolonged duration observed in vivo in the rat. PMID:1352222

  13. Watershed Data Management (WDM) database for Salt Creek streamflow simulation, DuPage County, Illinois, water years 2005-11

    USGS Publications Warehouse

    Bera, Maitreyee

    2014-01-01

    The U.S. Geological Survey (USGS), in cooperation with DuPage County Stormwater Management Division, maintains a USGS database of hourly meteorologic and hydrologic data for use in a near real-time streamflow simulation system, which assists in the management and operation of reservoirs and other flood-control structures in the Salt Creek watershed in DuPage County, Illinois. Most of the precipitation data are collected from a tipping-bucket rain-gage network located in and near DuPage County. The other meteorologic data (wind speed, solar radiation, air temperature, and dewpoint temperature) are collected at Argonne National Laboratory in Argonne, Ill. Potential evapotranspiration is computed from the meteorologic data. The hydrologic data (discharge and stage) are collected at USGS streamflow-gaging stations in DuPage County. These data are stored in a Watershed Data Management (WDM) database. An earlier report describes in detail the WDM database development including the processing of data from January 1, 1997, through September 30, 2004, in SEP04.WDM database. SEP04.WDM is updated with the appended data from October 1, 2004, through September 30, 2011, water years 2005–11 and renamed as SEP11.WDM. This report details the processing of meteorologic and hydrologic data in SEP11.WDM. This report provides a record of snow affected periods and the data used to fill missing-record periods for each precipitation site during water years 2005–11. The meteorologic data filling methods are described in detail in Over and others (2010), and an update is provided in this report.

  14. Capsaicin-induced genotoxic stress does not promote apoptosis in A549 human lung and DU145 prostate cancer cells.

    PubMed

    Lewinska, Anna; Jarosz, Paulina; Czech, Joanna; Rzeszutek, Iwona; Bielak-Zmijewska, Anna; Grabowska, Wioleta; Wnuk, Maciej

    2015-02-01

    Capsaicin is the major pungent component of the hot chili peppers of the genus Capsicum, which are consumed worldwide as a food additive. More recently, the selective action of capsaicin against cancer cells has been reported. Capsaicin was found to induce apoptosis and inhibit proliferation of a wide range of cancer cells in vitro, whereas being inactive against normal cells. As data on capsaicin-induced genotoxicity are limited and the effects of capsaicin against human lung A549 and DU145 prostate cancer cells were not explored in detail, we were interested in determining whether capsaicin-associated genotoxicity may also provoke A549 and DU145 cell death. Capsaicin-induced decrease in metabolic activity and cell proliferation, and changes in the cell cycle were limited to high concentrations used (≥ 100 μM), whereas, at lower concentrations, capsaicin stimulated both DNA double strand breaks and micronuclei production. Capsaicin was unable to provoke apoptotic cell death when used up to 250 μM concentrations. Capsaicin induced oxidative stress, but was ineffective in provoking the dissipation of the mitochondrial inner transmembrane potential. A different magnitude of p53 binding protein 1 (53BP1) recruitment contributed to diverse capsaicin-induced genotoxic effects in DU145 and A549 cells. Capsaicin was also found to be a DNA hypermethylating agent in A549 cells. In summary, we have shown that genotoxic effects of capsaicin may contribute to limited susceptibility of DU145 and A549 cancer cells to apoptosis in vitro, which may question the usefulness of capsaicin-based anticancer therapy, at least in a case of lung and prostate cancer. PMID:25813723

  15. Nouveaux analogues étendus du tétrathiafulvalène à espaceur conjugué rigide

    NASA Astrophysics Data System (ADS)

    Brisset, H.; Le Moustarder, S.; Blanchard, P.; Illien, B.; Riou, A.; Roncali, J.

    1998-06-01

    New hybrid tetrathiafulvalene analogues are built by insertion of bridged transdithienylethylene between two 1,4-dithiafulvenyl electron-releasing groups. Whereas the unbridged analogues are directly oxidized to the dication state, the rigidification of the conjugated spacerleads simultaneously to an increase of the -donor ability and a stabilization of the radical cation state. De nouveaux analogues étendus du tétrathiafulvalène ont été synthétisés par insertion du trans-dithiényléthylène rigide entre deux motifs électrodonneurs 1,4-dithiafulvényl. Alors que les composés non pontés sont oxydés directement à l'état de dication, la rigidification de l'espaceur conjugué conduit simultanément à une augmentation du caractère donneur-pi et à la stabilisation de l'état radical-cation.

  16. Hydraulic properties of the Prairie du Chien-Jordan aquifer, Shakopee Mdewakanton Sioux Community, southeastern Minnesota, 1997

    USGS Publications Warehouse

    Ruhl, James F.

    1999-01-01

    An aquifer test of the Prairie du Chien-Jordan aquifer was conducted in the Shakopee Mdewakanton Sioux Community located southwest of the Twin Cities metropolitan area. A well open to the Jordan Sandstone was pumped at 600 gallons per minute for 57 hours. Drawdown was monitored in three observation wells located near the pumped well. These wells were open to: (1) the Jordan Sandstone, the principal unit of the aquifer; (2) the Prairie du Chien Group, a secondary, carbonate-rock unit of the aquifer; and (3) a confined, glacial-drift sand aquifer. Test results indicate that the Jordan Sandstone had a transmissivity of 6,267 ft2/d, a storativity of 1.193 x 10-4, a horizontal hydraulic conductivity of 31 ft/d based on a saturated thickness of 204 ft, and a ratio of vertical to horizontal hydraulic conductivity of 5.29 x 10-4. The pumped well was hydraulically connected to the Prairie du Chien Group observation well. No drawdown was observed in the observation well completed in the confined, glacial-drift sand aquifer; thus, a hydraulic connection of this observation well to the pumped well was not indicated.

  17. Adaptation and Attenuation of Duck Tembusu Virus Strain Du/CH/LSD/110128 following Serial Passage in Chicken Embryos

    PubMed Central

    Sun, Ling; Li, Yunxia; Zhang, Yue; Han, Zongxi; Xu, Yang

    2014-01-01

    Duck Tembusu virus (DTMUV) is a newly emerging pathogenic flavivirus that has caused massive economic losses to the duck industry in China. In the current study, a virulent strain of DTMUV, designated Du/CH/LSD/110128, was isolated from the livers of diseased ducks and attenuated by serial passage in embryonated chicken eggs. The virus was partially attenuated after 50 and 70 passages and was fully attenuated after 90 passages, based on mortality and morbidity rates and viral loads in inoculated ducklings. Fourteen amino acid substitutions were observed in the capsid, prM, envelope, NS1, NS3, NS4A, NS4B, and NS5 proteins of the fully attenuated strain of Du/CH/LSD/110128, which might be responsible for the observed changes in replication and pathogenicity. A 72-nucleotide deletion was also observed in the 3′ untranslated region of the virus after 30 passages. The fully attenuated virus retained the immunogenicity of the parental strain, providing effective protection to challenge with virulent Du/CH/LSD/110128, and may represent a suitable candidate as a vaccine strain against DTMUV infection in ducks. Our results also lay the foundation for future studies on the replication and pathogenic mechanisms of DTMUV. PMID:24872514

  18. Une approche du temps et des fréquences. Vers le mètre et la seconde

    NASA Astrophysics Data System (ADS)

    Granveaud, Suzanne DéBarbat Et Michel

    1998-04-01

    A l'occasion du "Second Paris Cosmology Colloquium" tenu à l'Observatoire de Paris en 1994 (2-4 juin), une visite de l'Observatoire de Paris a fait connaître aux participants les richesses de l'Etablissement dont la première pierre fut posée le 21 juin 1667, et où une activité de recherche n'a pas cessé d'y être menée. Le descriptif de la visite conduite par l'un d'entre nous (S. Débarbat) est paru aux pages 528 à 531 des Actes du Colloque (World Scientific, 1995). Plusieurs des photographies reproduites aux pages 533 à 543 permettent d'apprécier "l'état des lieux", tandis que la page IV de couverture représente la pendule "astronomique" de 1710 qui orne l'une des salles du Bâtiment Perrault⋯

  19. Accouchement de jumeaux conjoints de découverte fortuite au cours du travail au CHU de Dakar

    PubMed Central

    Guèye, Mamour; Guèye, Serigne Modou Kane; Guèye, Mame Diarra Ndiaye; Diouf, Abdoul Aziz; Niang, Mouhamadou Mansour; Diallo, Moussa; Cissé, Mamadou Lamine; Moreau, Jean Charles

    2012-01-01

    L'objectif de cette étude était de rapporter 3 cas de jumeaux conjoints, discuter de l'importance du diagnostic anténatal et de décrire les particularités diagnostiques, thérapeutiques et évolutives. Sur 45700 accouchements du 1er Février 2009 au 31 Décembre 2011, 3 cas de jumeaux conjoints ont été enregistrés, soit 1 cas pour 15000 accouchements. Ces cas ont été diagnostiqués au cours du travail au décours d'une dystocie mécanique ou d'une césarienne réalisée pour une autre indication. Il s'agissait d'un cas de jumeaux conjoints thoraco-omphalopages, un cas de diprosopes et un cas de dicéphales. L'accouchement dans les trois cas était fait par voie haute permettant d'extraire des mort-nés frais. Nous insistons sur l'intérêt d'un diagnostic anténatal précoce par le recours à l’échographie afin d’éviter les accidents mécaniques d'un accouchement qui ne saurait s'accomplir par voie basse. PMID:23133702

  20. A quantitative analysis of naiad mollusks from the Prairie du Chien, Wisconsin dredge material site on the Mississippi River

    USGS Publications Warehouse

    Havlik, M.E.; Marking, L.L.

    1980-01-01

    The Prairie du Chien dredge material site contains about 100,000 cubic meters of material dredged from the East Channel of the Mississippi Riverin1976. Previous studies in that area suggested a rich molluscan fauna, but most studies were only qualitative or simply observations. Our study of this material was designed to determine the density and diversity of molluscan fauna, to assess changes in the fauna, to identify endemic species previously unreported, and to evaluate the status of the endangered Lampsilis higginsi. Ten cubic meters of dredge material were sieved to recover shells. Molluscan fauna at the site contained38 species of naiades and up to 1,737 identifiable valves per cubic meter. The endangered L. higginsi ranked18th In occurrence, accounted for only 0.52% of the identifiable shells, and averaged about three valves per cubic meter. From a total of 813 kg of naiades and gastropods, 6,339 naiad valves were identified. Five naiad species were collected at the site for the first time, and Eploblasma triquetra had not been reported previously in the Prairie du Chien area. Although the molluscan fauna has changed, the East Channel at Prairie du Chien is obviously suitable for L. higginsi.

  1. Etude séro-épidémiologique de la leishmaniose canine au centre du Maroc

    PubMed Central

    Fellah, Hajiba; Doughmi, Oursula; Maniar, Saâd; Lalami, Abdelhakim El Ouali

    2014-01-01

    Dans le monde, la leishmaniose viscérale humaine est connue pour avoir comme principale source d'infection les Canidés domestiques et sauvages. Au centre du Maroc, les données épidémiologiques, cliniques et parasitologiques sur la leishmaniose canine, sont quasiment inexistantes. Ce travail traite une étude prospective au cours de laquelle 61 sérums canins ont été analysés par un test rapide et par l'immunofluorescence indirecte. La sensibilité du test rapide par rapport à celle de l'immunofluorescence indirecte (IFI) est de 33,33%. La fréquence de la maladie chez les chiens s’élève à 9,83% (Test Rapide) et 24,59% (IFI). 73,33% des cas canins positifs à la sérologie sont asymptomatiques. Ce sont les jeunes chiens de moins de 5 ans qui sont les plus fréquemment atteints avec une sensibilité de la race Berger Allmand à l'infection. Cette étude a permis de mettre en évidence la présence de chiens leishmaniens (15 chiens séropositifs parmi 61) et de prouver l'existence du réservoir canin. Une stratégie de prévention active doit être mise en place. PMID:25852791

  2. A role for SIRT1 in cell growth and chemoresistance in prostate cancer PC3 and DU145 cells

    SciTech Connect

    Kojima, Keitaro; Ohhashi, Riyako; Fujita, Yasunori; Hamada, Nanako; Akao, Yukihiro; Nozawa, Yoshinori; Deguchi, Takashi; Ito, Masafumi

    2008-08-29

    SIRT1, which belongs to the family of type III histone deacetylase, is implicated in diverse cellular processes. We have determined the expression levels of SIRT1 in human prostate cancer cell lines and have examined the roles of SIRT1 in cell growth and chemoresistance. SIRT1 expression was markedly up-regulated in androgen-refractory PC3 and DU145 cells compared with androgen-sensitive LNCaP cells and its expression level was correlated with cell growth in PC3 cells. Treatment with a SIRT1 inhibitor, sirtinol, inhibited cell growth and increased sensitivity to camptothecin and cisplatin. Silencing of SIRT1 expression by siRNA also suppressed cell proliferation and reduced camptothecin resistance in PC3 cells, mimicking the chemosensitizing effect caused by sirtinol. Also in DU145 cells, sirtinol treatment enhanced sensitivity to camptothecin and cisplatin. These results suggest that up-regulation of SIRT1 expression may play an important role in promoting cell growth and chemoresistance in androgen-refractory PC3 and DU145 cells.

  3. Etude des aspects cliniques, échographiques et nutritionnels du syndrome des ovaires micropolykystiques (SOMPK) à Mbuji-Mayi, RD du Congo

    PubMed Central

    Kalenda, Louis Mbuyamba Ntobo; Mikenji, Justin Biayi; Nkoy, Albert Mwembo-Tambwe; Kayamba, Prosper Kalenga Muenze

    2014-01-01

    Introduction Le Syndrome des Ovaires Micropolykystiques (SOMPK) est polymorphe. L'objectif de cette étude était de déterminer la prévalence et rechercher les facteurs nutritionnels éventuellement associés. Méthodes Chez 300 patientes atteintes de SOMPK faisant l'objet de cette étude, les données anamnestiques, cliniques et échographiques, et les habitudes alimentaires ont été analysées. Les statistiques usuelles et les mesures d'association ont été utilisées pour analyser les résultats. Résultats La prévalence de SOMPK était de 23,6%. L’âge moyen des patientes avec SOMPK était 24 ± 7 ans et chez celles sans SOMPK 36 ± 7 ans (P < 0,05). Le risque de développer le SOMPK en présence d'un niveau de vie élevé était de 2,03 (RR = 2,03; IC à 95%: 1,73-2,38; P = 0,00). Le risque de développer le SOMPK en exerçant une activité légère est de 2,15 (RR = 2,15; IC à 95%: 1,87-2,87; P= 0,00). La proportion des patientes avec SOMPK ayant accumulé plus de 2400 kcal était de 59% vs 36% (P < 0,05) et le risque de développer le SOMPK lorsque l’énergie accumulée était supérieure à 2400 kcal était de 1,57 (RR = 1,57; IC à 95%: 1,33-1,85; P= 0,00). Conclusion Dans notre milieu la prévalence de SOMPK était de 23,6%. Les facteurs associés au SOMPK étaient l’âge, l’énergie accumulée de plus de 2400 Kcal, le niveau socio-économique élevé et l'activité physique légère. Des études analytiques plus poussées sont nécessaires, pour évaluer la force du risque que représentent ces différents facteurs étudiés. PMID:25870722

  4. Conversion du methanol en ethanol par carbonylation suivie d'hydrogenolyse

    NASA Astrophysics Data System (ADS)

    Gaucher, Melissa

    Ce projet de maîtrise s'inscrit dans le cadre des nouvelles filières énergétiques renouvelables et s'effectue au sein de la Chaire de recherche industrielle sur l'éthanol cellulosique créée par trois partenaires industriels (Enerkem, CRB et Ethanol Greenfield) et le gouvernement du Québec en collaboration avec l'Université de Sherbrooke. La stratégie d'un des partenaires, Enerkem, est de convertir par gazéification des résidus de biomasse non homogène en Syngas, ce gaz est ensuite converti en méthanol puis en éthanol. L'objectif principal de ce projet est la conversion catalytique de l'acétate en alcool. Un catalyseur commercial, composé de cuivre et de chrome, a permis l'obtention des conversions de plus de 95 % et une sélectivité pour l'éthanol de plus de 50 % avec l'acétate de méthyle, de 99 % avec l'acétate d'éthyle et de 50 % avec l'acétate de butyle. Les conditions optimales trouvées impliquent une température de 215 °C, une pression de 350 psig, une vitesse spatiale de 1800 h -1 H2 STP et un ratio H2 : Acétate de 7. Un catalyseur alternatif, à base de cuivre et de zinc, a aussi été testé. L'objectif secondaire est la carbonylation du méthanol en acétate. Cette étape a été réalisée en phase gazeuse où des rendements très élevés, soit plus de 2000 kg d'acétate de méthyle par kg de métal précieux à l'heure (kg AM/ kg métal précieux/h), ont été obtenus. Les conditions d'opérations testées impliquent une température variant entre 200-240 °C, une pression entre 250-600 psig, des ratios McOH : CO de 1 à 2,5. Mots clés: Carbonylation, Éthanol, Hydrogénolyse, Catalyse hétérogène.

  5. Mesure de la Polarisation des Lambda Produits dans les Collisions Positron-Electron AU Lep a L'aide du Detecteur Opal

    NASA Astrophysics Data System (ADS)

    Vandenplas, Denis

    Le Modele Standard est le cadre theorique general qui, jusqu'a present, a permis l'interpretation de tous les resultats experimentaux en physique des hautes energies. Cette theorie decrit, entre autres, la production d'une paire de particules elementaires, formee d'un quark et d'un antiquark, a partir de la desintegration de l'un des bosons mediateurs de l'interaction faible, le Z^0. Cependant, dans ce cas precis, la transformation subsequente des quarks primaires en particules reelles, un processus appele hadronisation, n'est decrite qu'a l'aide de modeles phenomenologiques. Afin de sonder les mecanismes de l'hadronisation, cette these presente la mesure du transfert du spin d'un quark etrange primaire a une particule appelee Lambda lors des desintegrations hadroniques du Z^0. L'etude a ete realisee dans le cadre de la collaboration OPAL, une des quatre experiences menees au collisionneur LEP, la ou des electrons et des positrons sont acceleres jusqu'a une energie commune, sqrt{s} = {rm E_ {cm}}, voisine de l'energie de production du rm Z^0, M_{Z ^0} egale a 91.3 GeV. La theorie electrofaible precise la direction du spin, c'est-a-dire la polarisation, d'un quark etrange primaire provenant de la desintegration d'un Z ^0. Quant a lui, le modele des quarks etablit que l'orientation du spin d'un Lambda est directement reliee a la polarisation du quark etrange dont il provient. La question est de determiner dans quelle mesure la polarisation du quark primaire est transmise au Lambda a la suite du processus de l'hadronisation, decrit dans le cadre de la ChromoDynamique Quantique. Une estimation, qui tient compte de tous ces differents aspects theoriques, evalue a 30% la polarisation des Lambda dont l'impulsion est superieure a 15 GeV/c. La mesure experimentale de la polarisation repose sur l'identification des Lambda a partir de la reconstitution de la desintegration Lambdato ppi^-. Ce processus, qui se deroule par le biais de l'interaction faible, viole la parite car

  6. Cout direct hospitalier des accidents vasculaires cérébraux à Parakou au nord du Benin

    PubMed Central

    Adoukonou, Thierry; Kouna-Ndouongo, Philomène; Codjia, Jean-Mannix; Covi, Richmine; Tognon-Tchegnonsi, Francis; Preux, Pierre-Marie; Houinato, Dismand

    2013-01-01

    Introduction Les accidents vasculaires cérébraux constituent un véritable problème de santé publique en Afrique avec une charge importante. Les données fiables sur sa réelle charge économique sont rares en Afrique. L'objectif de cette étude était d’évaluer le coût direct hospitalier des AVC à Parakou au Bénin. Méthodes Il s'agissait d'une étude transversale économique ayant inclus des patients hospitalisés pour un AVC à l'hôpital de Parakou entre le 1er Juin 2010 au 31Mai 2011. Les données concernant les différents postes de consommation ont été collectées selon la méthode dite bottom-up. Le coût était envisagé du point de vue de la société et du patient. L'unité du coût était le franc CFA (valeur en 2011). Une régression linéaire multiple était utilisée pour déterminer les meilleurs prédicteurs du coût. Résultats Ils étaient 78 patients dont 52 hommes, âgés en moyenne de 57 ans ± 10.9. Le NIHSS moyen était de 14,4. Le taux de mortalité était de 20,5%. Le coût direct moyen était de 316.810,3 (±230.774,8) F CFA (environ 704 ± 512 Euros). Les grands postes de consommation étaient les explorations paracliniques (34.3%) les soins et médicaments (28.4%) et les frais d'hospitalisation (17.9%). Les meilleurs prédicteurs du coût élevé étaient un AVC hémorragique, un NIHSS élevé à l'admission et une longue durée d'hospitalisation. Conclusion Cette étude suggère un coût élevé de la prise en charge actuelle des AVC à Parakou. PMID:24839529

  7. Renaud Paulian et le programme du CNRS sur les hautes montagnes à Madagascar: étage vs domaine

    PubMed Central

    Guillaumet, Jean-Louis; Betsch, Jean-Marie; Callmander, Martin W.

    2011-01-01

    Résumé Le programme intitulé « Étude des écosystémes montagnards dans la région malgache» (RCP 225/CNRS; responsable: Recteur Renaud Paulian) avait pour ambition de dégager leurs caractères généraux, l'origine des éléments constitutifs et de tester la validité d'un Domaine malgache des Hautes Montagnes proposé par Humbert dès 1951. De 1970 à 1973, trois campagnes (Andringitra; Chaînes anosyennes et Ankaratra; Itremo, Ibity et Marojejy) ont permis une caractérisation écologique des milieux particuliers ainsi que des analyses de systématique sur certains taxa connus pour leur intérêt biogéographique. La succession altitudinale des formations végétales, définies par des critères physionomiques et structuraux, est précisée par massif. Le dernier étage caractérisé par le fourré éricoïde et ses groupements associés ne correspond pas à l'Étage des Hautes Montagnes de l'Est africain. Des groupes de la faune (invertébrés hexapodes: Collemboles et Dermaptères) indiquent une disjonction entre les massifs du Nord (Tsaratanana, Marojejy), ceux du Centre et du Sud; des éléments de la flore (Pandanaceae, Araliaceae, Asteraceae) sont en cours d'analyse dans le même sens. Le Domaine des Hautes montagnes à Madagascar est une réalité écologique mais ne peut être défini floristiquement; chaque massif montagneux est une entité phytogéographique d'étages de végétation interdépendants inclus dans les différents Sous-Domaines du Centre. Les groupes peu mobiles de la faune indiquent globalement une dépendance trophique et bioclimatique (effet tampon du climat intraforestier) vis-à-vis des étages de végétation, mais peuvent réagir à des microclimats locaux par des décalages à leurs limites. PMID:21731422

  8. Epidémiologie et facteurs de risque des anomalies de fermeture du tube neural: données marocaines

    PubMed Central

    Radouani, Mohammed Amine; Chahid, Naima; Benmiloud, Loubna; Elammari, Laila; Lahlou, Khalid; Barkat, Amina

    2015-01-01

    Introduction Les anomalies de fermeture du tube neural sont des défauts congénitaux de la formation du système nerveux central. L'incidence varie entre 3 et 40 cas pour 10000 dans le monde. Il existe des facteurs de risque de survenue de cette affection. La prévention reste un élément important dans la prise en charge. L'objectif de ceete étude est d’étudier les paramètres sociodémographiques, maternels, obstétricaux et néonatals des anomalies de fermeture du tube neural et analyser les facteurs de risque responsables dans notre contexte. Méthodes Etude prospective cas-témoin sur 4 ans. Ont été recrutés tous les cas portant une malformation du tube neural isolée ou associée à d'autres malformations. Les données maternelles, obstétricales et néonatales ont été enregistrées. L'analyse statistique était réalisée par le biais d'un logiciel de statistiques SPSS version 17.0 pour Windows. Résultats Soixante huit cas ont été inclus. Quatre-vingts cinq pour cent des malformations étaient isolées. L'anencéphalie était l'anomalie la plus retrouvée (67%). L’âge maternel moyen était 31,03±7,50 ans. La consanguinité parentale était notée dans 9 cas. Un niveau socio-économique bas et un non suivi des grossesses ont été rapportés dans 29% des cas. L’étude a retrouvé des antécédents de mort-nés et de morts néonatales dans 4% des cas. La consommation de Fenugrec était significativement associée aux malformations du tube neural et a été retrouvée dans 8 cas contre 1 cas dans le groupe sain. La voie haute d'accouchement était utilisée dans 29% des cas. L’âge gestationnel moyen était de 35,55±4,16 semaines d'aménorrhée. Il n'y avait pas de prédominance de sexe. On avait noté une relation significative entre les malformations du tube neural et l'avènement d'une asphyxie périnatale, 15 cas présentaient un apgar à 0 à la première minute et 12 cas un apgar inférieur à 7 à la cinquième minute. Conclusion

  9. Petroleum exploration contribution to the structural history of Golfe du Lin

    SciTech Connect

    Curnelle, R.

    1988-08-01

    Petroleum exploration has strongly contributed to the knowledge of the post-Hercynian structural history of the Golfe du Lion. It shows three stages: (1) Pyrenean orogenesis which started in the Late Cretaceous and culminated during the Eocene (40-75 Ma), (2) Oligocene rifting associated with the oceanic accretion of the Provencal basin, and (3) post-Messinian deformations due to salt tectonics. Pyrenean deformation of the area seems to have been controlled by its Hercynian inheritance: the major transcurrent faults of the Cevenole belt, Nimes, and the Durance. They favored displacement of the deformation in a northeasterly direction along the fault corridors, inside which the overthrust units were put into place. These east-west-oriented structures show northward vergence. The Pyrenean axial zone in this downthrown part of the belt consist of progressively more northerly units offset by transverse faults. The Oligocene rifting is represented by a series of horsts and deeply subsiding grabens linked to preexisting major faults. The horst are deeply eroded and the Mesozoic carbonates are karstified. The extension of the Messinian evaporitic deposits known throughout the Mediterranean basin is located north of the shallower deep-water well. The gravitational deformation of the salt is expressed by a large number of listric faults which originate in the salt bodies. The sedimentary sequence ends with a thick discordant, erosional, undeformed Pliocene-Quaternary series.

  10. Cri-Du-Chat Syndrome: Clinical Profile and Chromosomal Microarray Analysis in Six Patients.

    PubMed

    Espirito Santo, Layla Damasceno; Moreira, Lília Maria Azevedo; Riegel, Mariluce

    2016-01-01

    Cri-du-chat syndrome is a chromosomal disorder caused by a deletion of the short arm of chromosome 5. The disease severity, levels of intellectual and developmental delay, and patient prognosis have been related to the size and position of the deletion. Aiming to establish genotype-phenotype correlations, we applied array-CGH to evaluate six patients carrying cytogenetically detected deletions of the short arm of chromosome 5 who were followed at a genetics community service. The patients' cytogenetic and clinical profiles were reevaluated. A database review was performed to predict additional genes and regulatory elements responsible for the characteristic phenotypic and behavioral traits of this disorder. Array-CGH analysis allowed for delineation of the terminal deletions, which ranged in size from approximately 11.2 Mb to 28.6 Mb, with breakpoints from 5p15.2 to 5p13. An additional dup(8)(p23) (3.5 Mb), considered to be a benign copy number variation, was also observed in one patient. The correlation coefficient value (ρ = 0.13) calculated indicated the presence of a weak relationship between developmental delay and deletion size. Genetic background, family history, epigenetic factors, quantitative trait locus polymorphisms, and environmental factors may also affect patient phenotype and must be taken into account in genotype-phenotype correlations. PMID:27144168

  11. Commande numérique d'axe avec compensation du couple résistant

    NASA Astrophysics Data System (ADS)

    Reis Costa, J. C.; Fadel, M.; de Fomel, B.

    1991-03-01

    A PWM fed synchronous motor drive with high performances is achieved by utilization of a state space control with load torque compensation. With a simple model, a state space load torque observer is studied and implemented. This control law, applied to a synchronous motor, results in a low sensitive position control system. La réalisation d'un variateur de position de haute performance, constitué d'une machine synchrone associée à un onduleur de tension MLI, peut s'obtenir en utilisant des techniques d'état associées à la compensation du couple résistant. Nous avons, dans ce travail, développé un observateur dynamique de couple, élaboré à partir d'un modèle simple assurant une bonne évaluation de la charge entrainée. L'utilisation d'un tel dispositif, nous permet d'obtenir un servomoteur synchrone doué de caractéristiques indépendantes de la charge.

  12. Cri-Du-Chat Syndrome: Clinical Profile and Chromosomal Microarray Analysis in Six Patients

    PubMed Central

    Espirito Santo, Layla Damasceno; Moreira, Lília Maria Azevedo; Riegel, Mariluce

    2016-01-01

    Cri-du-chat syndrome is a chromosomal disorder caused by a deletion of the short arm of chromosome 5. The disease severity, levels of intellectual and developmental delay, and patient prognosis have been related to the size and position of the deletion. Aiming to establish genotype-phenotype correlations, we applied array-CGH to evaluate six patients carrying cytogenetically detected deletions of the short arm of chromosome 5 who were followed at a genetics community service. The patients' cytogenetic and clinical profiles were reevaluated. A database review was performed to predict additional genes and regulatory elements responsible for the characteristic phenotypic and behavioral traits of this disorder. Array-CGH analysis allowed for delineation of the terminal deletions, which ranged in size from approximately 11.2 Mb to 28.6 Mb, with breakpoints from 5p15.2 to 5p13. An additional dup(8)(p23) (3.5 Mb), considered to be a benign copy number variation, was also observed in one patient. The correlation coefficient value (ρ = 0.13) calculated indicated the presence of a weak relationship between developmental delay and deletion size. Genetic background, family history, epigenetic factors, quantitative trait locus polymorphisms, and environmental factors may also affect patient phenotype and must be taken into account in genotype-phenotype correlations. PMID:27144168

  13. Apport du rayonnement synchrotron à l'étude de cheveux archéologiques

    NASA Astrophysics Data System (ADS)

    Bertrand, L.; Chevallier, P.; Doucet, J.; Simionovici, A.; Tsoucaris, G.; Walter, P.

    2002-07-01

    La préservation dans certains contextes archéologiques des cheveux humains et des fibres animales est favorisée par leur transformation chimique au contact d'objets métalliques. Afin de mieux comprendre les phénomènes complexes mis en jeu, nous avons étudié expérimentalement la fixation de cations métalliques (Cu et Pb) dans des cheveux modèles à partir de différentes méthodes de caractérisation utilisant le rayonnement X synchrotron. Nous avons ainsi pu mettre en évidence la fixation spécifique d'une partie de ces cations au sein des lipides structurés du cheveu. La comparaison entre échantillons modèles et archéologiques apporte de nouvelles données concernant les premières étapes d'altération des cheveux archéologiques.

  14. Conformational epitope mapping of Pru du 6, a major allergen from almond nut.

    PubMed

    Willison, LeAnna N; Zhang, Qian; Su, Mengna; Teuber, Suzanne S; Sathe, Shridhar K; Roux, Kenneth H

    2013-10-01

    Tree nuts are a widely consumed food. Although enjoyed safely by most individuals, allergic reactions to tree nuts, including almond, are not uncommon. Almond prunin (Pru du 6), an 11S globulin (legumin), is an abundant nut seed protein and a major allergen. Conformational epitope mapping studies of prunin have been performed with a murine monoclonal antibody (mAb) 4C10. This mAb reacts with non-reduced but not reduced prunin in immunoblotting assays, indicating the recognition of a conformational epitope. 4C10 competes with patient IgE, as assessed by ELISA, indicating clinical significance of the epitope. To characterize the 4C10 epitope, hydrogen/deuterium exchange (HDX) monitored by 14.5 T Fourier transform ion cyclotron resonance mass spectrometry (MS) was performed on the native prunin-4C10 complex and on uncomplexed native prunin. Several epitope candidate peptides that differ in deuterium uptake between the complexed and uncomplexed forms were identified. The epitope was further mapped by analyzing chimeric molecules incorporating segments of the homologous soybean allergen, Gly m 6, in immunoassays. These data indicate that the 4C10 epitope overlaps with a subset of patient IgE binding epitopes on almond prunin and further supports HDX-MS as a valid technique for mapping conformational epitopes. PMID:23498967

  15. Norcantharidin induced DU145 cell apoptosis through ROS-mediated mitochondrial dysfunction and energy depletion.

    PubMed

    Shen, Bo; He, Pei-Jie; Shao, Chun-Lin

    2013-01-01

    Norcantharidin (NCTD), a demethylated analog of cantharidin derived from blister beetles, has attracted considerable attentions in recent years due to their definitely toxic properties and the noteworthy advantages in stimulating bone marrow and increasing the peripheral leukocytes. Hence, it is worth studying the anti-tumor effect of NCTD on human prostate cancer cells DU145. It was found that after the treatment of NCTD with different concentrations (25-100 μM), the cell proliferation was significantly inhibited, which led to the appearance of micronucleus (MN). Moreover, the cells could be killed in a dose-/time-dependent manner along with the reduction of PCNA (proliferating cell nuclear antigen) expression, destruction of mitochondrial membrane potential (MMP), down-regulation of MnSOD, induction of ROS, depletion of ATP, and activation of AMPK (Adenosine 5'-monophosphate -activated protein kinase) . In addition, a remarkable release of cytochrome c was found in the cells exposed to 100 μM NCTD and exogenous SOD-PEG could eliminate the generation of NCTD-induced MN. In conclusion, our studies indicated that NCTD could induce the collapse of MMP and mitochondria dysfunction. Accumulation of intercellular ROS could eventually switch on the apoptotic pathway by causing DNA damage and depleting ATP. PMID:24367681

  16. Cancer métaplasique du sein: à propos d'un cas

    PubMed Central

    Babahabib, Moulay Abdellah; Chennana, Adil; Hachi, Aymen; Kouach, Jaoud; Moussaoui, Driss; Dhayni, Mohammed

    2014-01-01

    Les carcinomes métaplasiques du sein sont des tumeurs rares. Ils constituent un groupe hétérogène de tumeurs définis selon l'organisation mondiale de la santé comme étant un carcinome canalaire infiltrant mais comportant des zones de remaniements métaplasiques (de type épidermoïde, à cellules fusiformes, chondroïde et osseux ou mixte), qui varient de quelques foyers microscopiques à un remplacement glandulaire complet. Les aspects cliniques et radiologiques ne sont pas spécifiques. Le traitement associe la chirurgie, la radiothérapie et la chimiothérapie. L'hormonothérapie n'a pas de place. Le pronostic est sombre. L'histopathologie combinée à l'immunohistochimie permet de poser un diagnostic sure. Etant donné que la prise en charge thérapeutique est limitée, une nouvelle approche moléculaire pourrait modifier cette contribution faible et mal cernée des traitements systémiques classiques. Les patientes atteintes de carcinome métaplasique mammaire pourraient bénéficier de traitements ciblés, ce qui reste à confirmer par des essais cliniques. PMID:25870723

  17. Childhood apraxia of speech without intellectual deficit in a patient with cri du chat syndrome.

    PubMed

    Marignier, Stéphanie; Lesca, Gaetan; Marguin, Jessica; Bussy, Gérald; Sanlaville, Damien; des Portes, Vincent

    2012-06-01

    We report an 11-year-old girl for whom the diagnosis of cri du chat syndrome (CdCS) was made during a genetic investigation of childhood apraxia of speech. The patient presented with the classic chromosome 5 short arm deletion found in CdCS. The microdeletion, characterised using aCGH (array Comparative Genomic Hybridisation), was 12.85 Mb, overlapping the 5p15.2 and 5p15.3 critical regions. CdCS is typically associated with severe mental retardation while this patient had normal intellectual performance, confirmed by normal results from categorisation tasks. This mild phenotype was assessed using a comprehensive cognitive battery. Language evaluation showed normal receptive vocabulary scores, in contrast with obvious oro-facial dyspraxia. Disabled fine motor skills were confirmed as well as weak visuo-spatial reasoning abilities. In conclusion, fine cognitive assessment may be worthwhile for patients with CdCS since good intellectual functioning may be masked by severe speech and gestural dyspraxia, thus requiring specific teaching and rehabilitation strategies. PMID:22510527

  18. Tumeur pseudopapillaire et solide du pancréas: une cause rare de masse abdominale

    PubMed Central

    Hasbi, Samir; Menfaa, Mohammed; Sakit, Fouad; Laaroussi, Jamal; Choho, Abdelkrim

    2015-01-01

    La tumeur pseudopapillaire et solide du pancréas (TPPSP) est une tumeur rare, c'est une cause rare de masse abdominale. Elle touche surtout les jeunes femmes. Elle est d’étiopathogénie encore peu connue, caractérisée par un potentiel malin atténué avec un risque d'extension locale faible et d’évolution métastatique rare. Elle reste de bon pronostic après exérèse chirurgicale complète. Nous rapportons un cas chez une adolescente révélé par une masse épigastrique peu douloureuse. L’échographie abdominale complétée par la tomodensitométrie ont confirmés le diagnostique de tumeur pancréatique. L’étude anatomopathologique et immunohistologique étaient en faveur d'une TPPSP. PMID:26985279

  19. Implementing Quality Assurance for the Numerical Research Software Dune / PDELab / DuMux

    NASA Astrophysics Data System (ADS)

    Flemisch, B.; Bastian, P.; Kempf, D.; Koch, T.; Helmig, R.

    2015-12-01

    Quality assurance and, in particular, automated testing, should be one of the key elements of modern software development. However, applying common techniques from software engineering to numerical frameworks, such as Dune, may be challenging since the requirements for a test might be very different to standard software. This talk gives an overview of our work in describing system tests for numerical software and developing test tools to ensure that qualitative and quantitative properties of PDE discretizations are preserved. The developed tools are employed in the Dune discretization module Dune-PDELab and the porous-media simulator DuMux.The newly developed module dune-testtools provides the following components: A domain specific language for feature modelling, which is naturally integrated into the workflow of numerical simulation. Tools to test whether a given PDE discretization does still yield the correct result without performance (or scalability) regressions. Integration of the above tools into a CMake based build system. Extensions to the Dune core modules to support the development of system tests.

  20. Bioaccessibility and excretion of arsenic in Niu Huang Jie Du Pian pills

    SciTech Connect

    Koch, Iris; Sylvester, Steven; Lai, Vivian W.-M.; Owen, Andrew; Reimer, Kenneth J. Cullen, William R.

    2007-08-01

    Traditional Chinese medicines (TCMs) often contain significant levels of potentially toxic elements, including arsenic. Niu Huang Jie Du Pian pills were analyzed to determine the concentration, bioaccessibility (arsenic fraction soluble in the human gastrointestinal system) and chemical form (speciation) of arsenic. Arsenic excretion in urine (including speciation) and facial hair were studied after a one-time ingestion. The pills contained arsenic in the form of realgar, and although the total arsenic that was present in a single pill was high (28 mg), the low bioaccessibility of this form of arsenic predicted that only 4% of it was available for absorption into the bloodstream (1 mg of arsenic per pill). The species of arsenic that were solubilized were inorganic arsenate (As(V)) and arsenite (As(III)) but DMAA and MMAA were detected in urine. Two urinary arsenic excretion peaks were observed: an initial peak several (4-8) hours after ingestion corresponding to the excretion of predominantly As(III), and a larger peak at 14 h corresponding predominantly to DMAA and MMAA. No methylated As(III) species were observed. Facial hair analysis revealed that arsenic concentrations did not increase significantly as a result of the ingestion. Arsenic is incompletely soluble under human gastrointestinal conditions, and is metabolized from the inorganic to organic forms found in urine. Bioaccessible arsenic is comparable to the quantity excreted. Facial hair as a bio-indicator should be further tested.

  1. Management of wildlife causing damage at Argonne National Laboratory-East, DuPage County, Illinois

    SciTech Connect

    1995-04-01

    The DOE, after an independent review, has adopted an Environmental Assessment (EA) prepared by the US Department of Agriculture (USDA) which evaluates use of an Integrated Wildlife Damage Management approach at Argonne National Laboratory-East (ANL-E) in DuPage County, Illinois (April 1995). In 1994, the USDA issued a programmatic Environmental Impact Statement (EIS) that covers nationwide animal damage control activities. The EA for Management of Wildlife Causing Damage at ANL-E tiers off this programmatic EIS. The USDA wrote the EA as a result of DOE`s request to USDA to prepare and implement a comprehensive Wildlife Management Damage Plan; the USDA has authority for animal damage control under the Animal Damage Control Act of 1931, as amended, and the Rural Development, Agriculture and Related Agencies Appropriations Act of 1988. DOE has determined, based on the analysis in the EA, that the proposed action does not constitute a major Federal action significantly affecting the quality of the human environment within the meaning of the National Environmental Policy Act of 1969 (NEPA). Therefore, the preparation of an EIS is not required. This report contains the Environmental Assessment, as well as the Finding of No Significant Impact (FONSI).

  2. Depleted uranium: all the questions about DU and Gulf War syndrome are not yet answered.

    PubMed

    Bertell, Rosalie

    2006-01-01

    For 15 years, the debate about depleted uranium (DU) and its detrimental effects on the health of veterans of the Gulf War of 1991, on the Iraqi people and military (and subsequently on the people of Kosovo, Afghanistan, and Iraq during the second war) has remained unresolved. Meanwhile, the number of Gulf War veterans who have developed the so-called Gulf War syndrome has risen to about one-third of the 800,000 U.S. forces deployed, and unknown proportions of those involved in the subsequent wars. Uncounted civilians and personnel of other nations that fought in Iraq and other wars since 1991 have also been afflicted. The veterans have suffered from multiple serious physiological disorders and have received little or no official recognition, medical relief, or compensation. We need to take another look at this issue, using a holistic and interactive model for the toxic matrix of exposures, identifying the major roadblocks to resolving the scientific questions, and finding appropriate medical and political responses. This commentary is such an attempt. PMID:16981628

  3. High-resolution Laue-type DuMond curved crystal spectrometer

    SciTech Connect

    Szlachetko, M.; Berset, M.; Dousse, J.-Cl.; Hoszowska, J.; Szlachetko, J.

    2013-09-15

    We report on a high-resolution transmission-type curved crystal spectrometer based on the modified DuMond slit geometry. The spectrometer was developed at the University of Fribourg for the study of photoinduced X-ray spectra. K and L X-ray transitions with energies above about 10 keV can be measured with an instrumental resolution comparable to their natural linewidths. Construction details and operational characteristics of the spectrometer are presented. The variation of the energy resolution as a function of the focal distance and diffraction order is discussed. The high sensitivity of the spectrometer is demonstrated via the 2s-1s dipole-forbidden X-ray transition of Gd which could be observed despite its extremely low intensity. The precision of the instrument is illustrated by comparing the sum of the energies of the Au K–L{sub 2} and L{sub 2}–M{sub 3} cascading transitions with the energy of the crossover K–M{sub 3} transition as well as by considering the energy differences of the Gd Kα{sub 1} X-ray line measured at five different diffraction orders. Finally, to demonstrate the versatility of the spectrometer, it is shown that the latter can also be used for in-house extended X-ray absorption fine structure measurements.

  4. Processus mis en jeu dans l'evolution morpho-dynamique de Roberts Bank (Delta du Fraser): Observation et modelisation hydrodynamiques et sedimentaires

    NASA Astrophysics Data System (ADS)

    Meule, Samuel

    Roberts Bank couvre le delta intertidal entre le bras principal du fleuve Fraser et la pointe du Cap Roberts en Colombie Britannique, Canada. Sous la pression du developpement urbain et la modification du regime sedimentaire, cette plage de sable fin est soumise a une erosion significative. L'identification des forces hydrodynamiques, leur importance et leur interaction permettent de determiner les zones de transport, et donc la stabilite de Roberts Bank. Deux periodes de mesures associees a des phases de modelisation de la houle et des courants ont ete effectuees lors de ce travail. La premiere periode de mesure, entre le 29 juin et le 8 juillet 2001, a permis l'identification de processus hydrodynamiques et sedimentaires associes aux forts courants de maree presents le long de Roberts Bank. La seconde phase de mesure, entre le 1er mars et le 26 mars 2002, a permis d'etudier les processus de remise en suspension associes a la houle. Des phases de modelisation ont ete menees a partir des connaissances acquises sur le terrain, afin d'affiner la comprehension des processus sedimentaires et notamment les interactions houle - courant - sediment. Les mecanismes, mis en evidence dans cette etude, participent au faconnage de Roberts Bank, contribuent a son erosion et a la mise en place de nouvelles structures sedimentaires. Les courants de flot de maree vont initier la creation de nuages de resuspension de sediment depuis le fond. En eau peu profonde, la composante " onshore" du courant de maree induit un transport a la cote, tandis qu'en eau plus profonde une faible composante " offshore" du courant peut favoriser un transport au large le long de la pente. Les chenaux, les dunes subaquatiques et les surfaces d'erosion affleurantes fournissent une rugosite de fond suffisante a la generation de turbulence et donc de nuages de sediment en suspension. Lors de la maree de jusant, les sediments resuspendus en eau peu profonde, sont transportes vers le large a partir d

  5. Un essai contrôlé randomisé: effet du port de chaussures à talons hauts sur le squelette appendiculaire inferieur

    PubMed Central

    Koussihouèdé, Fifamè Eudia Nadège; Falola, Jean-Marie; Fousseni, El-Mansour Barres

    2015-01-01

    Introduction Véritable attribut de la féminité, le port de chaussures à talons est devenu une exigence professionnelle dans certaines structures des pays en développement comme le Bénin. L'objectif de ce travail est de déterminer les effets spécifiques du port de chaussures à talons hauts sur le squelette appendiculaire inférieur. Méthodes Des examens radiographiques de face et de profil de la cheville et du genou ont été effectués sur 122 femmes volontaires, âgées en moyenne de 25,09 ± 1,34 ans et ayant les genu varum qui ont participé à cette étude. Résultats Les résultats ont indiqué une augmentation significative de l’écart inter malléolaire, de l’écart inter condylien, de l'angle antérieur du pied et de l'angle fémoro-patellaire. Une diminution significative de l'angle postérieur du pied a été constatée. Conclusion Le port de chaussures à talons hauts est l'une des causes de la gonarthrose, des troubles des articulations de la cheville et du pied. PMID:26113922

  6. Quand le malheur frappe les bénéficiaires de la sécurité du revenu. Sur qui peuvent-ils s’appuyer ?

    PubMed Central

    Tousignant, Michel; Caron, Jean

    2013-01-01

    Cette étude analyse les conditions de réalisation du soutien social dans les quartiers de Saint-Henri et de la Pointe Saint-Charles, en comparant un groupe de 61 prestataires de la sécurité du revenu avec un échantillon de 21 personnes de la population vivant au-dessus du seuil de la pauvreté, et en fonction du degré de détresse dans chaque groupe. Elle vise également à décrire comment une adversité vécue par les prestataires avec ou sans détresse vient briser ou modifier le réseau de soutien. Les résultats indiquent que le réseau social est moins fiable en présence de détresse qu’en son absence, que les personnes en détresse se sont vues plus fréquemment refuser du soutien ou être abandonnées et qu’elles ont davantage de personnes nuisibles dans leur entourage. De plus, les événements vécus comportent souvent une atteinte à leur réputation, des menaces, des trahisons et des refus à un droit légitime. Les personnes en détresse sont aussi davantage isolées. PMID:16505926

  7. Mesure et retroaction sur un qubit multi-niveaux en electrodynamique quantique en circuit non lineair

    NASA Astrophysics Data System (ADS)

    Boissonneault, Maxime

    L'electrodynamique quantique en circuit est une architecture prometteuse pour le calcul quantique ainsi que pour etudier l'optique quantique. Dans cette architecture, on couple un ou plusieurs qubits supraconducteurs jouant le role d'atomes a un ou plusieurs resonateurs jouant le role de cavites optiques. Dans cette these, j'etudie l'interaction entre un seul qubit supraconducteur et un seul resonateur, en permettant cependant au qubit d'avoir plus de deux niveaux et au resonateur d'avoir une non-linearite Kerr. Je m'interesse particulierement a la lecture de l'etat du qubit et a son amelioration, a la retroaction du processus de mesure sur le qubit de meme qu'a l'etude des proprietes quantiques du resonateur a l'aide du qubit. J'utilise pour ce faire un modele analytique reduit que je developpe a partir de la description complete du systeme en utilisant principalement des transfprmations unitaires et une elimination adiabatique. J'utilise aussi une librairie de calcul numerique maison permettant de simuler efficacement l'evolution du systeme complet. Je compare les predictions du modele analytique reduit et les resultats de simulations numeriques a des resultats experimentaux obtenus par l'equipe de quantronique du CEASaclay. Ces resultats sont ceux d'une spectroscopie d'un qubit supraconducteur couple a un resonateur non lineaire excite. Dans un regime de faible puissance de spectroscopie le modele reduit predit correctement la position et la largeur de la raie. La position de la raie subit les decalages de Lamb et de Stark, et sa largeur est dominee par un dephasage induit par le processus de mesure. Je montre que, pour les parametres typiques de l'electrodynamique quantique en circuit, un accord quantitatif requiert un modele en reponse non lineaire du champ intra-resonateur, tel que celui developpe. Dans un regime de forte puissance de spectroscopie, des bandes laterales apparaissent et sont causees par les fluctuations quantiques du champ electromagnetique

  8. Detection du tore de poussieres dans les noyaux actifs de galaxies avec COMIC, la nouvelle camera infrarouge du systeme d'optique adaptative de l'ESO. (Resume de these).

    NASA Astrophysics Data System (ADS)

    Marco, O.

    1998-05-01

    L'observation a haute resolution angulaire a connu un nouvel elan avec la mise au point de systemes d'optique adaptative fonctionnant dans l'infrarouge. La camera COMIC, seconde camera dediee a ADONIS, le systeme d'optique adaptative equipant le telescope de 3.60 metres de l'ESO, permet l'observation dans le domaine spectral 3-5 microns a la limite de resolution angulaire du telescope. La caracterisation de la camera au laboratoire a Meudon et Grenoble, puis la determination de ses performances sur le site au Chili sont l'objet de la premiere partie de cette These. Une methode originale d'evaluation des magnitudes limites atteintes est proposee, qui prend en compte a chaque stade les differents facteurs de perte de detectivite entre les mesures au laboratoire et celles en conditions reelles. Cette approche pourra etre envisagee chaque fois que l'on a connaissance a priori des conditions d'observation (quantifiees en particulier par le rapport de Strehl, ou encore par une estimation du seeing). L'etude de la region centrale (~1 arcsec) des Noyaux Actifs de Galaxies necessite l'acces a la haute resolution angulaire. En particulier, la poussiere chaude emet dans le domaine 1-5 microns. L'observation des NAG avec un systeme d'optique adaptative est donc tout indiquee. La theorie d'unification des NAG prevoit la presence d'un tore moleculaire et poussiereux, responsable d'effets masquant selon l'angle de visee sous lequel on les observe, induisant des proprietes observationnelles distinctes pour des objets supposes identiques. Les observations real isees avec ADONIS & COMIC de NGC 7469 et NGC 1068 ont montre la presence d'une grande quantite de poussieres chaudes localisees a l'emplacement du tore presume, mais aussi melangees avec le gaz de la region d'emission de raies etroites. La haute resolution angulaire atteinte a permis de preciser la temperature des poussieres chaudes, leur masse, et leur distribution spatiale autour de la source centrale du NAG. Ces resultats

  9. Etude du strabisme chez des enfants de 0 à 15 ans suivis a Lubumbashi, République Démocratique du Congo: analyse des aspects épidémiologiques et cliniques

    PubMed Central

    Bienvenu, Yogolelo Asani; Angel, Musau Nkola; Sebastien, Mbuyi Musanzayi; Philippe, Cilundika Mulenga; Léon, Kabamba Ngombe; Eugene, Twite Kabange; Chami, Cham Lubamba; Prosper, Kalenga Muenze Kayamba; Claude, Speeg-Schatz; Gaby, Chenge Borasisi

    2015-01-01

    Introduction Le strabisme est défini comme un syndrome à double composante: motrice et sensorielle. Le but de ce travail est de décrire les aspects épidémiologiques et cliniques du strabisme chez l'enfant congolais de 0 à 15 ans dans la ville de Lubumbashi. Méthodes Il s'agit d'une étude descriptive longitudinale sur les aspects épidémiologiques et cliniques du strabisme chez l'enfant congolais de 0 à 15 ans dans la ville de Lubumbashi entre Décembre 2012 à Décembre 2013. Nous avons recueilli l’âge des patients, leur sexe, leur provenance, le type de strabisme, la réfraction, le fond d'oeil, les antécédents (hérédité) ainsi que le type de la déviation strabique observé sur 70 patients. Résultats Nous avons observé 70 cas de strabisme manifeste dont 31 cas (44,28%) étaient dans la tranche d’âge comprise entre 0 et 5 ans. L’âge moyen de nos patients était de 6,7 ans avec une prédominance du sexe féminin, soit 51,42%. Le strabisme était convergent dans 65,71%, divergent dans 30%, et vertical dans 4,28%. Les ésotropies représentaient 65 cas (92,85%), quatre cas (5,71%) avaient un antécédent familial de strabisme au premier degré de parenté, 21 cas (30%) au second degré de parenté, 45 cas (64,28%) n'avaient pas cet antécédent. L'oeil gauche était le plus dominé dans 30% des cas. Les facteurs favorisant le strabisme étaient inconnus dans 54 cas (77,14%). Le strabisme était secondaire à l'hypermétropie chez 32 patients (42,71%). Conclusion La fréquence du strabisme dans la ville de Lubumbashi chez les enfants âgés de 0 à 15 ans est de 0,50%. Comme dans la plupart des études sur le strabisme de l'enfant, c'est l’ésotropie qui est la déviation la plus commune. PMID:26834919

  10. Place du traitement chirurgical sous circulation extracorporelle à cœur battant dans les cancers du rein avec envahissement cave supra-diaphragmatique: à propos de sept cas

    PubMed Central

    Lahyani, Mounir; Karmouni, Tarik; Elkhader, Khalid; Koutani, Abdellatif; Andaloussi, Ahmed Ibn Attya

    2014-01-01

    Ce travail vise à analyser les résultats de la néphrectomie avec thrombectomie atrio-cave sous circulation extracorporelle (CEC) chez sept patients ayant un cancer du rein avec envahissement cave supra-diaphragmatique et de discuter les indications opératoires. Sept patients, six hommes et une femme dont l’âge varie entre 46ans et 65ans, ont été opérés d'un cancer du rein avec extension atrio-cave. L’écho-doppler a toujours permis la mise en évidence de l'extension veineuse mais la limite supérieure du thrombus était formellement identifiée par l'examen tomodensitométrique quatre fois, et par la résonance magnétique nucléaire dans tous les cas. Tous les patients ont été opérés sous CEC à cœur battant en normothermie. Un seul décès postopératoire est survenu. La durée du séjour en réanimation a été de 4,5 jours. Cinq patients ont eu à distance une dissémination métastatique. Cinq malades ont eu une médiane de survie de 11,5 mois (de 7 à16). Un malade a subi une métastasectomie pulmonaire 6 mois après la néphrectomie. L'exérèse des thrombi atrio-caves a été facilitée par la CEC avec une mortalité et une morbidité postopératoires acceptables mais les résultats à distance ont été décevants. Cette intervention ne peut être proposée qu'aux patients n'ayant aucune extension locorégionale et générale décelable, ce qui souligne l'importance des examens morphologiques préopératoires. PMID:25995777

  11. Thermal characterization of Li-ion cells using calorimetric techniques

    SciTech Connect

    ROTH,EMANUEL P.

    2000-05-31

    The thermal stability of Li-ion cells with intercalating carbon anodes and metal oxide cathodes was measured as a function of state of charge and temperature for two advanced cell chemistries. Cells of the 18650 design with Li{sub x}CoO{sub 2} cathodes (commercial Sony cells) and Li{sub x}Ni{sub 0.8}Co{sub 0.2}O{sub 2} cathodes were measured for thermal reactivity. Accelerating rate calorimetry (ARC) was used to measure cell thermal runaway as a function of state of charge (SOC), microcalorimetry was used to measure the time dependence of thermal output, and differential scanning calorimetry (DSC) was used to study the thermal reactivity of the individual components. Thermal decomposition of the anode solid electrolyte interphase (SEI) layer occurred at low temperatures and contributes to the initiation of thermal runaway. Low temperature reactions from 40 C--70 C were observed during the ARC runs that were SOC dependent. These reactions measured in the microcalorimeter decayed over time with power-law dependence and were highly sensitive to SOC and temperature. ARC runs of aged and cycled cells showed complete absence of these low-temperature reactions but showed abrupt exothermic spikes between 105--135 C. These results suggest that during aging the anode SEI layer is decomposing from a metastable state to a stable composition that is breaking down at elevated temperatures.

  12. Calorimetric determinations and theoretical calculations of polymorphs of thalidomide

    NASA Astrophysics Data System (ADS)

    Lara-Ochoa, F.; Pérez, G. Espinosa; Mijangos-Santiago, F.

    2007-09-01

    The analysis of the thermograms of thalidomide obtained for the two reported polymorphs α and β by differential scanning calorimetry (DSC) shows some inconsistencies that are discussed in the present work. The conception of a new polymorph form, named β ∗, allowed us to explain the observed thermal behavior more satisfactorily. This new polymorph shows enantiotropy with both α and β polymorphs, reflected in the unique endotherm obtained in the DSC-thermograms, when a heating rate of 10 °C/min is applied. Several additional experiments, such as re-melting of both polymorph forms, showed that there is indeed a new polymorph with an endotherm located between the endotherms of α and β. IR, Raman, and powder X-ray permit us to characterize the isolated compound, resulting from the re-melting of both polymorph forms. Mechanical calculations were performed to elucidate the conformations of each polymorph, and ab initio quantum chemical calculations were performed to determine the energy of the more stable conformers and the spatial cell energy for both polymorphs α and β. These results suggested a possible conformation for the newly discovered polymorph β ∗.

  13. Calorimetric glass transition in a mean-field theory approach

    PubMed Central

    Mariani, Manuel Sebastian; Parisi, Giorgio; Rainone, Corrado

    2015-01-01

    The study of the properties of glass-forming liquids is difficult for many reasons. Analytic solutions of mean-field models are usually available only for systems embedded in a space with an unphysically high number of spatial dimensions; on the experimental and numerical side, the study of the properties of metastable glassy states requires thermalizing the system in the supercooled liquid phase, where the thermalization time may be extremely large. We consider here a hard-sphere mean-field model that is solvable in any number of spatial dimensions; moreover, we easily obtain thermalized configurations even in the glass phase. We study the 3D version of this model and we perform Monte Carlo simulations that mimic heating and cooling experiments performed on ultrastable glasses. The numerical findings are in good agreement with the analytical results and qualitatively capture the features of ultrastable glasses observed in experiments. PMID:25675523

  14. Two Calorimetrically Distinct States of Liquid Water Below 150 Kelvin

    PubMed

    Johari; Hallbrucker; Mayer

    1996-07-01

    Vapor-deposited amorphous solid and hyperquenched glassy water were found to irreversibly transform, on compression at 77 kelvin, to a high-density amorphous solid. On heating at atmospheric pressure, this solid became viscous water (water B), with a reversible glass-liquid transition onset at 129 +/- 2 kelvin. A different form of viscous water (water A) was formed by heating the uncompressed vapor-deposited amorphous solid and hyperquenched liquid water. On thermal cycling up to 148 kelvin, water B remained kinetically and thermodynamically distinct from water A. The occurrence of these two states, which do not interconvert, helps explain both the configurational relaxation of water and stress-induced amorphization. PMID:8688057

  15. Calorimetric calibration of pyroelectric gamma-radiation detectors

    SciTech Connect

    Strakovskaya, R.Y.; Sras', A.G.

    1985-07-01

    A method has been devised for calibrating a pyroelectric dosimeter, which is based on comparing the readings obtained with it in a gamma-ray beam with the readings of an integral calorimeter under stationary conditions, with the latter previously calibrated from Joule heat. The calorimeter used was in the form of a closed shell, whose overall thermo-emf was independent of the spatial distribution of the heat sources in it, the value being proportional to the integral heat flux through the shell. Measurements were made not only with a quasiisotropic radiation field but also in directed fields. The overall error in calibrating the pyroelectric detectors by this method was less than or equal to plus or minus 10%.

  16. Calorimetric thermometry of meteoritic troilite: Preliminary thermometer relationships

    NASA Technical Reports Server (NTRS)

    Allton, Judith H.; Wentworth, Susan J.; Gooding, James L.

    1994-01-01

    Thermodynamic properties of the alpha/beta phase transformation in terrestrial troilite (FeS), as measured by differential scanning calorimetry (DSC), vary systematically with prior thermal history of the troilite, as imposed under laboratory conditions. Both the transition temperature and enthalpy change for the alpha/beta transformation decrease with increasing maximum temperature of prior heat treatment. DSC measurements on troilite from various meteorites indicate clear differences in the alpha/beta thermodynamic properties that are consistent with differences in the natural thermal histories of the meteorites.

  17. Calorimetric studies of the elongation of Avena coleoptile segments.

    PubMed

    Bogie, H E; Kresheck, G C; Harmet, K H

    1976-06-01

    Elongation rate and heat produced by Avena coleoptile segments suspended in sucrose buffer solutions were measured at pH values from 3.5 to 8.5. The caloric efficiency of elongation (CEE) was defined as the ratio of the rate of elongation to the rate of heat production. Elongation and CEE were greatest at intermediate pH values, but heat production (about 1 cal/g.hr) was insensitive to pH within the limits of experimental error (+/-20%). Quantitative agreement was found between the results of previous respiration studies and the rate of heat production in an aerobic atmosphere, which indicates that oxidative metabolism accounts for essentially all energy changes in the cell, so matter flow is a significant component of the bioenergetics of cell function. Indole-3-acetic acid up to 1 mm, produced about a 10-fold increase in elongation rate, a 5-fold increase of the CEE, and a 25% increase in heat production. Above this concentration, sharp drops in both elongation and heat production occurred, without altering the CEE at pH 6.5, but greatly decreasing the CEE at pH 4.5. Elongation and CEE showed marked decreases after 4 hours in an anaerobic atmosphere, but heat production did not exhibit a proportional decrease. These studies indicate that rate of cell elongation in the presence and absence of auxin is not directly proportional to the overall metabolism of the cell. PMID:16659582

  18. A calorimetric investigation of doxorubicin-polymer bead interactions.

    PubMed

    Waters, Laura J; Swaine, Tanya S; Lewis, Andrew L

    2015-09-30

    Isothermal titration calorimetry (ITC) was utilised to investigate suitability of the technique to determine the stoichiometry and thermodynamics of the interactions that occur between a commonly used chemotherapeutic drug, namely doxorubicin, and a polymer bead-based drug delivery embolisation system (DC Bead™). Six temperatures were selected for drug-polymer titrations (293-313 K) and in all cases an initially exothermic signal reverted to an endothermic response upon the saturation of the beads with drug. From these experiments, and subsequent calculations, the molar ratio of drug to SO3(-) (polymer) was found to be 0.4:1 at all temperatures studied. Enthalpic data was calculated from the raw ITC data with an average enthalpy of drug-polymer binding of - 14.8 kJ mol(-1) at 293 K through to - 19.4 kJ mol(-1) at 313 K implying the process is enthalpically-driven yet only affected by an increase in experimental temperature to a limited extent whereby an increase in experimental temperature results in a small increase in the negativity in change in enthalpy recorded. The application of ITC in this study (with its unique ability to monitor real-time interactions and facilitate stoichiometric calculations) resolves the lack of knowledge regarding the thermodynamics of this specific drug-polymer interaction. This study confirms that ITC is not only useful for this specific system, but also highlights the potential use of ITC for more general studies in this area. PMID:26209073

  19. Calorimetric study of Skyrmionic chiral magnet MnSi

    NASA Astrophysics Data System (ADS)

    Samatham, S. Shanmukharao; Ganesan, V.

    2014-04-01

    We present the analysis of specific internal energy as a function of magnetic fields in ordered, intermediate and paramagnetic phases of MnSi. Signatures of the formation of Skyrmion lattice, in conical order region, is identified by a hump-like structure in region-I. Gradual melting of blue phase, with magnetic fields, is demonstrated.

  20. A calorimetric study of precipitation in aluminum alloy 2219

    NASA Astrophysics Data System (ADS)

    Papazian, John M.

    1981-02-01

    Precipitate microstructures in aluminum alloy 2219 were characterized using transmission electron microscopy (TEM) and differential scanning calorimetry (DSC). The DSC signatures of individual precipitate phases were established by comparing the DSC and TEM results from samples that had been aged such that only one precipitate phase was present. These signatures were then used to analyze the commercial tempers. It was found that DSC could readily distinguish between the T3, T4, T6, T8 and O tempers but could not distinguish amongst T81, T851 and T87. Small amounts of plastic deformation between solution treatment and aging had a significant effect on the thermograms. Aging experiments at 130 and 190 °C showed that the aging sequence and DSC response of this alloy were similar to those of pure Al-Cu when the increased copper content is taken into account. Further aging experiments at temperatures between room temperature and 130 °C showed pronounced changes of the GP zone dissolution peak as a function of aging conditions. These changes were found to be related to the effect of GP zone size on the metastable phase boundary and on the GP zone dissolution kinetics.

  1. Calorimetric studies of natural talc: Enthalpy of dehydroxylation

    NASA Astrophysics Data System (ADS)

    Ogorodova, L. P.; Kiseleva, I. A.

    2011-10-01

    The standard dehydroxylation enthalpy of natural talc Mg3[Si4O10](OH)2 (87.8 ± 9.0 kJ/mol at 298.15 K) and the enthalpy of formation of dehydrated talc from the elements (Δf H {el/o} (298.15 K) = -5527.0 ± 9.0 kJ/mol) were determined for the first time using Hess's law, based on the total values of the enthalpy increments in heating a sample from room temperature to 973 K and the enthalpies of dissolution at 973 K for dehydrated talc measured in this work and those previously determined for talc and corresponding oxides.

  2. Calorimetric evaluation of commercial Ni-MH cells and charges

    NASA Technical Reports Server (NTRS)

    Darcy, Eric C.; Hughes, Brent M.

    1995-01-01

    The test objectives are to evaluate the electrical and thermal performance of commercial Ni-MH cells and to evaluate the effectiveness of commercial charge control circuits. The ultimate design objectives are to determine which cell designs are most suitable for scale-up and to guide the design of future Shuttle and Station based battery chargers.

  3. Superconducting calorimetric alpha particle sensors for nuclear nonproliferation applications

    SciTech Connect

    Horansky, Robert D.; Ullom, Joel N.; Beall, James A.; Hilton, Gene C.; Irwin, Kent D.; Dry, Donald E.; Hastings, Elizabeth P.; Lamont, Stephen P.; Rudy, Clifford R.; Rabin, Michael W.

    2008-09-22

    Identification of trace nuclear materials is usually accomplished by alpha spectrometry. Current detectors cannot distinguish critical elements and isotopes. We have developed a detector called a microcalorimeter, which achieves a resolution of 1.06 keV for 5.3 MeV alphas, the highest resolving power of any energy dispersive measurement. With this exquisite resolution, we can unambiguously identify the {sup 240}Pu/{sup 239}Pu ratio in Pu, a critical measurement for ascertaining the intended use of nuclear material. Furthermore, we have made a direct measurement of the {sup 209}Po ground state decay.

  4. Simulated performance of the calorimetric electron telescope (CALET) experiment

    NASA Astrophysics Data System (ADS)

    Akaike, Y.; Taira, K.; Kasahara, K.; Torii, S.; Shimizu, Y.; Yoshida, K.; CALET Collaboration

    2010-03-01

    CALET is a detector planned to be on-board the Japanese Experiment Module Exposed Facility (JEM-EF) of the International Space Station. The CALET mission aims at revealing unsolved problems in high energy phenomena of the Universe by carrying out a precise measurement of the high energy electrons in 1 GeV-20 TeV, the gamma-rays in 20 MeV to a few TeV and the nuclei in a few 10 GeV-1000 TeV. The main detector is composed of imaging calorimeter (IMC), total absorption calorimeter (TASC), silicon pixel array (SIA) and anti-coincidence detector (ACD) to detect various kinds of particles in very wide energy range. The total absorber thickness is 31 radiation lengths for electromagnetic particles and 1.4 interaction mean free paths for protons. Monte Carlo simulation study has been carried out for optimization of the detector performance in observing each kind of particles. We obtained following performance about the observation of very high energy (>100 GeV) electrons, which is a main target of the CALET experiment: (1) Effective geometrical factor is about 7000 cm2 sr. (2) Energy resolution is better than a few %. (3) Angular resolution is better than 0.1°. (4) Proton rejection power is ˜105 with the electron detection efficiency better than 95%. We also present the simulated performance of the CALET experiment in observing other particles.

  5. Binding of nucleotides to nucleoside diphosphate kinase: a calorimetric study.

    PubMed

    Cervoni, L; Lascu, I; Xu, Y; Gonin, P; Morr, M; Merouani, M; Janin, J; Giartosio, A

    2001-04-17

    The source of affinity for substrates of human nucleoside diphosphate (NDP) kinases is particularly important in that its knowledge could be used to design more effective antiviral nucleoside drugs (e.g., AZT). We carried out a microcalorimetric study of the binding of enzymes from two organisms to various nucleotides. Isothermal titration calorimetry has been used to characterize the binding in terms of Delta G degrees, Delta H degrees and Delta S degrees. Thermodynamic parameters of the interaction of ADP with the hexameric NDP kinase from Dictyostelium discoideum and with the tetrameric enzyme from Myxococcus xanthus, at 20 degrees C, were similar and, in both cases, binding was enthalpy-driven. The interactions of ADP, 2'deoxyADP, GDP, and IDP with the eukaryotic enzyme differed in enthalpic and entropic terms, whereas the Delta G degrees values obtained were similar due to enthalpy--entropy compensation. The binding of the enzyme to nonphysiological nucleotides, such as AMP--PNP, 3'deoxyADP, and 3'-deoxy-3'-amino-ADP, appears to differ in several respects. Crystallography of the protein bound to 3'-deoxy-3'-amino-ADP showed that the drug was in a distorted position, and was unable to interact correctly with active site side chains. The interaction of pyrimidine nucleoside diphosphates with the hexameric enzyme is characterized by a lower affinity than that with purine nucleotides. Titration showed the stoichiometry of the interaction to be abnormal, with 9--12 binding sites/hexamer. The presence of supplementary binding sites might have physiological implications. PMID:11294625

  6. Calorimetric studies of the growth of anaerobic microbes.

    PubMed

    Miyake, Hideo; Maeda, Yukiko; Ishikawa, Takashi; Tanaka, Akiyoshi

    2016-09-01

    This article aims to validate the use of calorimetry to measure the growth of anaerobic microbes. It has been difficult to monitor the growth of strict anaerobes while maintaining optimal growth conditions. Traditionally, optical density and ATP concentration are usually used as measures of the growth of anaerobic microbes. However, to take these measurements it is necessary to extract an aliquot of the culture, which can be difficult while maintaining anaerobic conditions. In this study, calorimetry was used to continuously and nondestructively measure the heat generated by the growth of anaerobic microbes as a function of time. Clostridium acetobutylicum, Clostridium beijerinckii, and Clostridium cellulovorans were used as representative anaerobic microbes. Using a multiplex isothermal calorimeter, we observed that peak time (tp) of C. acetobutylicum heat evolution increased as the inoculation rate decreased. This strong correlation between the inoculation rate and tp showed that it was possible to measure the growth rate of anaerobic microbes by calorimetry. Overall, our results showed that there is a very good correlation between heat evolution and optical density/ATP concentration, validating the use of the method. PMID:27012376

  7. Methodologie de conception numerique d'un ventilateur helico-centrifuge basee sur l'emploi du calcul meridien

    NASA Astrophysics Data System (ADS)

    Lallier-Daniels, Dominic

    La conception de ventilateurs est souvent basée sur une méthodologie « essais/erreurs » d'amélioration de géométries existantes ainsi que sur l'expérience de design et les résultats expérimentaux cumulés par les entreprises. Cependant, cette méthodologie peut se révéler coûteuse en cas d'échec; même en cas de succès, des améliorations significatives en performance sont souvent difficiles, voire impossibles à obtenir. Le projet présent propose le développement et la validation d'une méthodologie de conception basée sur l'emploi du calcul méridien pour la conception préliminaire de turbomachines hélico-centrifuges (ou flux-mixte) et l'utilisation du calcul numérique d'écoulement fluides (CFD) pour la conception détaillée. La méthode de calcul méridien à la base du processus de conception proposé est d'abord présentée. Dans un premier temps, le cadre théorique est développé. Le calcul méridien demeurant fondamentalement un processus itératif, le processus de calcul est également présenté, incluant les méthodes numériques de calcul employée pour la résolution des équations fondamentales. Une validation du code méridien écrit dans le cadre du projet de maîtrise face à un algorithme de calcul méridien développé par l'auteur de la méthode ainsi qu'à des résultats de simulation numérique sur un code commercial est également réalisée. La méthodologie de conception de turbomachines développée dans le cadre de l'étude est ensuite présentée sous la forme d'une étude de cas pour un ventilateur hélico-centrifuge basé sur des spécifications fournies par le partenaire industriel Venmar. La méthodologie se divise en trois étapes: le calcul méridien est employé pour le pré-dimensionnement, suivi de simulations 2D de grilles d'aubes pour la conception détaillée des pales et finalement d'une analyse numérique 3D pour la validation et l'optimisation fine de la géométrie. Les résultats de calcul m

  8. Nouveau procédé de synthèse du nitrure d'aluminium

    NASA Astrophysics Data System (ADS)

    Haussonne, J. M.; Lostec, J.; Bertot, J. P.; Lostec, L.; Sadou, S.

    1993-04-01

    Thermodynamic considerations show that, even at room temperature, pure aluminium can react with nitrogen to form the aluminium nitride AlN. However, pure aluminium does not exist: it is always surrounded by an alumina shell that protects the metal from further reactions. Furthermore, in the hypothesis where one has been able to make aluminium react with nitrogen, an aluminium nitride shell will protect as well the metal core from further oxidation. Prompted by the Lanxide process allowing to form Al/Al2O3 composites, we have mixed aluminium powders with lithium salts, and easily synthesized pure aluminium nitride by heating the mixed powders in nitrogen at temperatures ranging from 800 to 1200 °C. Starting from aluminium powders with a specific area ranging from 0.3 to 4 m^2/g, we have been able to produce aluminium nitride with specific are ranging from 1 to 20 m^2/g. Mixed with Y203-CaO and sintered at 1720 °C in N2, we obtained AIN ceramics owning 92% density and 160 W/m.K thermal conductivity. Les calculs thermodynamiques montrent que, même à température ambiante, l'aluminium pur peut réagir avec l'azote pour former le nitrure d'aluminium AlN. Cependant, la poudre d'aluminium pur n'existe pas : ses grains sont toujours entourés d'une couche d'alumine protectrice. De plus, dans l'hypothèse où l'on pourrait faire réagir de la poudre d'aluminium avec de l'azote, il se formerait de même une couche protectrice de nitrure d'aluminium qui empêcherait le centre des grains de réagir. S'inspirant du “procédé Lanxide” permettant de réaliser des composites Al/Al2O3, nous avons mélangé de la poudre d'aluminium avec des sels de lithium, et synthétisé du nitrure d'aluminium pur en portant ce mélange dans l'azote à une température pouvant être comprise entre 800 et 1 200 °C. Utilisant des poudres d'aluminium possédant une surface spécifique comprise entre 0,3 et 4 m^2/g, nous avons obtenu une poudre de nitrure d'aluminium avec une surface sp

  9. Evaluation experimentale et theorique du comportement a la flexion de nouveaux poteaux en materiaux composites

    NASA Astrophysics Data System (ADS)

    Metiche, Slimane

    entre ces proprietes est due au nombre de couches utilisees dans chaque zone ainsi qu'a l'orientation des fibres de chaque couche. Un total de vingt-trois prototypes de dimensions differentes; ont ete testes en flexion jusqu'a la rupture. Deux types de fibres de verre de masses lineaires differentes, ont ete utilisees afin d'evaluer l'effet du type de fibres sur le comportement a la flexion. Un nouveau montage experimental permettant de tester tous les types de poteaux en PRF a ete dimensionne et fabrique selon les recommandations decrites dans les normes ASTM D 4923-01 et ANSI C 136.20-2005. Un modele analytique base sur la theorie des poutres en elasticite lineaire est propose dans cette these. Ce modele predit avec une bonne precision le comportement experimental charge---deflexion ainsi que la deflexion maximale au sommet des poteaux en PRF; constitues de plusieurs zones de caracteristiques geometriques et mecaniques differentes. Une procedure de dimensionnement des poteaux en PRF, basee sur les resultats experimentaux obtenus dans le cadre de la presente these, est egalement proposee. Les resultats obtenus dans le cadre de la presente these permettront le developpement et l'amelioration des regles de conception utiles et pratiques a l'usage des concepteurs et des industriels du domaine des poteaux en PRF. Les retombees de cette recherche sont a la fois economiques et technologiques, car les resultats obtenus constitueront une banque de donnees qui contribueront au developpement des normes de calcul, et par consequent a l'optimisation des materiaux utilises, et serviront a valider de futurs resultats et modeles theoriques.

  10. Thermal Regime and Meteorological Parameters Monitoring in Alpine Permafrost Rockwalls: the Aiguille du Midi

    NASA Astrophysics Data System (ADS)

    Morra di Cella, U.; Cremonese, E.; Deline, P.; Gruber, S.; Pogliotti, P.; Ravanel, L.

    2009-04-01

    During the last decades the alpine region has revealed to be extremely sensitive to ongoing increasing temperatures and permafrost has been identified as one of six cryospheric indicators of global climate change. In high-mountain regions the permafrost evidences are scarse and punctual, while its occurrence is wide and its distribution is mainly controlled by complex topography and ground cover condition. In such environment, steep bedrock slopes are abundant and contain a significant proportion of permafrost whose thermal response is very fast compared to permafrost in gentle morphology because of its less amount of ice content. Due to logistical problems like accessibility, costs, weather conditions, etc..., monitoring sites in such environments are few, while an increase of measurements of rockwall temperature and system energy balance is fundamental for the calibration and validation of both physical and statistical permafrost models. Started in the framework of the French-Italian project PERMAdataROC (www.fondazionemontagnasicura.org/multimedia/permadataroc/) and presently developped within the EU co-funded project PermaNET (www.permanet-alpinespace.eu), several monitoring sites have been equipped during the last years in the Western Alps from a collaboration of Swiss, French and Italian researchers, with the aim to cover the widest range of climatic, topographic, morphological and geological conditions. In such network, the Aiguille du Midì can be considered one of the most advanced site in high-mountain permafrost research thanks to the convergence of several instrumental approaches, but also a "cooperation laboratory" among different research groups. The site has been choosen because of its elevation, aspects variability, steep slopes and accessibility all over the year. In details, ARPA Valle d'Aosta in collaboration with University of Zurich started in 2006 the monitoring of rockwall thermal regimes and of some meteorological parameters on the different

  11. Les traumatismes fermés du rein: à propos de 55 observations

    PubMed Central

    Ksiri, Khalid; Goultein, Issam; Aboutaeib, Rachid; Dakir, Mohamed; Rabii, Redouaune; Debbagh, Adil; Bennani, Saad; Meziane, Fathi

    2014-01-01

    Le rein est l'organe le plus fréquemment atteint lors des traumatismes urologiques. Actuellement la prise en charge des traumatismes rénaux est de plus en plus conservatrice. Nous avons réalisé une étude rétrospective portant sur 55 cas de traumatisme fermé du rein, colligés au service d'urologie au CHU Ibn Rochd de Casablanca sur une période de 6 ans étalée entre 2006 et 2012. Le but de ce travail est d'analyser notre prise en charge thérapeutique et les résultats obtenus en les comparants à différentes séries de la littérature. Le but final étant d'améliorer la prise en charge des traumatismes fermés du rein au sein de notre établissement sanitaire. L’âge moyen était de 26 ans. Le sexe ratio (H/F) était de 10. Les étiologies étaient dominées par les accidents de la voie publique (27 cas), et les chutes (11cas). Cinq patients se sont présentés en état de choc et opérés en urgence. Tous nos patients ont eu une tomodensitométrie rénale permettant de classer les traumatismes selon l'AAST (American Association for the Surgery of Trauma): 25% de lésions grade I, 9% de lésions grade II, 38,6% de lésions grade III, 22,7% de lésions grade IV, et 4,5% de lésions grade V. Le traitement conservateur était efficace chez 40 cas, dont 6 ont bénéficié d'une montée de sonde JJ. Le traitement chirurgical était nécessaire chez 15 cas, 5 en urgence immédiate et 10 en urgences différées après une attitude conservatrice initiale. Après un recul moyen de 11 mois les patients traités de façon conservatrice ont évolué favorablement. Devant l’évolution favorable de nos patients ayant eu une simple surveillance et tenant compte des résultats de la littérature, nous pensons qu'en l'absence de lésions intra-abdominales associées ou d'instabilité hémodynamique, la simple surveillance reste la méthode thérapeutique de choix. PMID:25374632

  12. Commande non linéaire en vitesse d'un servomoteur synchrone avec calcul de trajectoire et estimation du couple résistant

    NASA Astrophysics Data System (ADS)

    Le Pioufle, B.; Georgiou, G.

    1992-10-01

    In this paper, a method improving performances and robustness of nonlinear control of synchronous servomotor is proposed. A speed trajectory, asymptotically tracked by the nonlinear controller, is computed in real time and permits to obtain th optimum torque during the speed transients. A load torque estimator is included in the control. Simulation and experimentation results are presented. Dans cet article, une méthode est proposée pour améliorer robustesse et performances de la commande non linéaire du servomoteur synchrone. La méthode consiste à calculer en temps réel un trajectoire asymptotique pour la vitesse, engendrant un couple moteur optimum pendant la durée du transitoire de vitesse. Un estimateur du couple résistant est utilisé. Des simulations et des résultats expérimentaux sont présentés.

  13. Carcinome à cellule vitreuse du col de l'utérus: à propos d'un cas et revue de littérature

    PubMed Central

    Hakimi, Ihssane; Zazi, Abdelghani; Chahdi, Hafsa; Guelzim, Khalid; Kouach, Jaouad; Babahabib, Myabdellah; Elhassani, Myehdi; Rahali, Driss Moussaoui; Dehayni, Mohammed

    2015-01-01

    Le carcinome à cellule vitreuse du col de l'utérus est un type de histologique rare de cancer du col de l'utérus qui survient à un âge plus jeune, et s'associe au risque élevé d’échec thérapeutique et le pronostic est plus mauvais en comparaison au type cellulaire squameux. La radiothérapie est associée au risque diminué de récidive. Le but de cette étude est de récapituler à travers d'une observation et une revue de littérature les données sur l'incidence, le comportement clinique et la survie globale de patients avec le carcinome à cellule vitreuse du col de l'utérus. PMID:26664556

  14. Bactericidal activity of DU-6859a compared to activities of three quinolones, three beta-lactams, clindamycin, and metronidazole against anaerobes as determined by time-kill methodology.

    PubMed

    Spangler, S K; Jacobs, M R; Appelbaum, P C

    1997-04-01

    The activities of DU-6859a, ciprofloxacin, levofloxacin, sparfloxacin, piperacillin, piperacillin-tazobactam, imipenem, clindamycin, and metronidazole against 11 anaerobes were tested by the broth microdilution and time-kill methods. DU-6859a was the most active drug tested (broth microdilution MICs, 0.06 to 0.5 microg/ml), followed by imipenem (MICs, 0.002 to 4.0 microg/ml). Broth macrodilution MICs were within 3 (but usually 1) dilutions of the broth microdilution MICs. All compounds were bactericidal at the MIC after 48 h; after 24 h, 90% killing was shown for all strains when the compounds were used at four times the MIC. DU-6859a at < or = 0.5 microg/ml was bactericidal after 48 h. PMID:9087503

  15. A Coupled Modeling Approach for Root-Soil Interaction Processes Using DuMuX

    NASA Astrophysics Data System (ADS)

    Schröder, N.; Helmig, R.; Flemisch, B.; Koch, T.

    2015-12-01

    The water and nutrient uptake of plant roots in soils have a crucial influence on soil physical processes. The interacting processes between plant roots and soil are important for several agricultural problems, for example water management or leaching of pesticides. However, the coupled mechanisms of local soil and root water flow, transport of dissolved substances, root growth, and root uptake are difficult to measure and thus experimental data are rare. Numerical models can be used to understand these complex soil-root systems and help to analyze and interpret experimental measurements. The model approach presented here couples a root system and a soil model. Crucial for this approach is the 1D-3D grid coupling which combines a 1D network grid (root system) with the 3D soil grid. Based on that grid coupling, local processes are defined, for instance the local water uptake of a single root segment. Here, the interface conditions between roots and soil play a major role and we use local grid refinement strategies to better resolve these interface processes. This grid refinement of the 3D soil grid is based on the root network (1D grid) and adapts if root growth occurs. It offers the possibility to describe processes in the soil-plant continuum in a more physical manner avoiding empirical descriptions of root water uptake as a function of bulk matric potential, osmotic potential, root length density, and transpiration rate. Our coupling approach is included into the framework of DuMux, an open-source simulator for flow and transport processes in porous media. This implementation combines biological, chemical and physical processes in soil, inside roots, and at root-soil interfaces, and is contained in a sustainable and consistent framework for the implementation. We will show example simulations describing water flow, solute transport and root growth in a soil-root system.

  16. Consanguinity in Centre d'Étude du Polymorphisme Humain (CEPH) pedigrees

    PubMed Central

    Stevens, Eric L; Heckenberg, Greg; Baugher, Joseph D; Roberson, Elisha DO; Downey, Thomas J; Pevsner, Jonathan

    2012-01-01

    A set of Centre d'Étude du Polymorphisme Humain (CEPH) cell lines serves as a large reference collection that has been widely used as a benchmark for allele frequencies in the analysis of genetic variants, to create linkage maps of the human genome, to study the genetics of gene expression, to provide samples to the HapMap and 1000 Genomes projects, and for a variety of other applications. An explicit feature of the CEPH collection is that these multigenerational families represent reference panels of known relatedness, consisting mostly of three-generation pedigrees with large sibships, two parents, and grandparents. We applied identity-by-state (IBS) and identity-by-descent (IBD) methods to high-density genotype data from 186 CEPH individuals in 13 families. We identified unexpected relatedness between nominally unrelated grandparents both within and between pedigrees. For one pair, the estimated Cotterman coefficient of relatedness k1 exceeded 0.2, consistent with one-eighth sharing (eg, first-cousins). Unexpectedly, significant IBD2 values were discovered in both second-degree and parent–child relationships. These were accompanied by regions of homozygosity in the offspring, which corresponded to blocks lacking IBS0 in purportedly unrelated parents, consistent with inbreeding. Our findings support and extend a 1999 report, based on the use of short tandem-repeat polymorphisms, that several CEPH families had regions of homozygosity consistent with autozygosity. We benchmarked our IBD approach (called kcoeff) against both RELPAIR and PREST software packages. Our findings may affect the interpretation of previous studies and the design of future studies that rely on the CEPH resource. PMID:22274586

  17. Narrative discourse and sociocognitive abilities of a child with Cri-du-Chat syndrome.

    PubMed

    Albano, Stefania; Piccardi, Laura; Pizzamiglio, Maria Rosa; Volpe, Cristino; D'Amico, Simonetta

    2013-01-01

    The authors investigated narrative competence, sociocognitive abilities and emotion comprehension in a 9-year-old child (FS) with Cri-du-Chat Syndrome (CdCS) who had only a mild mental delay and relatively preserved language. Considering that the production of narratives is a major step in development and in the acquisition of learning skills related to conceptual, linguistic, structural, and pragmatic knowledge, and in the development of psychological lexicon, that is, the ability to use theory of mind (ToM) processes also in atypical development, this case provided an opportunity to study aspects of this genetic syndrome never investigated before. The authors found that the child's performance on different stories was comparable to that of chronological age controls for several narrative and emotional competences and even better than that of mental age controls. However, her ability to reason was still incomplete according ToM; in fact, FS was able to express her mental states, but she was unable to understand emotions, specifically mixed emotions. This finding suggests that in CdCS children with a well-developed language narrative and emotional competence could be a point of strength for improving their social skills with important effects on their familiar and school life. Also in CdCS children with the typical poor developed language, the narrative discourse could be introduced in their communication by means of any type of alternative language (i.e., sign language or augmentative and alternative communication) to improve their social abilities and to reduce behavioral disorders due to the difficulty in expressing their personal experiences. PMID:23534097

  18. Antiosteoporotic activity of Du-Zhong-Wan water extract in ovariectomized rats.

    PubMed

    Li, Fei; Yang, Xiaolin; Bi, Jianping; Yang, Zhonglin; Zhang, Chunfeng

    2016-09-01

    Context Eucommiae Cortex and Radix Dipsaci, occurring in a ratio of 1:1 in Du-Zhong-Wan (DZW), a Chinese herbal medicine, is available as a water extract followed by ethanol precipitation for the treatment of osteoporosis, fractures and menopausal syndrome. Objective This study investigates the protective effects of DZW in ovariectomy (OVX)-induced bone loss in a rat osteopenia model. Materials and methods Sixty Sprague-Dawley rats were randomly divided into the sham-operated group (SHAM) and five OVX subgroups: OVX with vehicle (OVX), 17β-estradiol (E2) and with three graded doses of DZW. Daily oral administration of the different samples started on the fifth week and lasted for 12 weeks, respectively. The body weight, uterus wet weight, serum biochemical parameters, bone mineral density (BMD), bone biomechanical properties, bone microarchitecture and immunohistochemistry were examined. Results Compared with the SHAM group, the DZW treatment significantly reversed the osteoporotic changes in OVX rats. The DZW-H group showed that serum tartrate-resistant acid phosphatase 5b (TRACP-5b) levels reduced by 152.25% (p < 0.01) and osteocalein (OCN) levels dose dependently increased by 118.43% (p < 0.01) as compared with the OVX group. Compared with the OVX group, the DZW at different three dosages of DZW evidently increased the right femur BMD by 112.43, 114.56 and 116.45%, and dramatically promoted bone quality and bone strength (p < 0.05). Further, immunohistochemical evaluation also showed that DZW administration increased ER expression in uteri (p < 0.01). Conclusions DZW exhibits an anti-osteoporotic effect, probably mediated via phyto-estrogenic effects. It might be a potential herbal alternative for the management of postmenopausal osteoporosis. PMID:26760929

  19. Les Cicatrices Retractiles Post-Brulures Du Membre Inferieur Chez L’Enfant

    PubMed Central

    Sankale, A.A.; Manyacka Ma Nyemb, P.; Coulibaly, N.F.; Ndiaye, A.; Ndoye, M.

    2010-01-01

    Summary Il s'agit d'une étude faisant ressortir les aspects épidémiologiques, cliniques et thérapeutiques des séquelles de brûlures du membre inférieur chez l'enfant, à propos de 42 cas colligés au service de chirurgie infantile de l'Hôpital Aristide Le Dantec (Sénégal). L'âge moyen retrouvé est de 5 ans et 3 mois, et le sex-ratio garçons/filles de 1,8/1. La brûlure thermique est causée par une flamme dans 33% des cas, par un liquide chaud dans 21% des cas, et par des braises dans 21% des cas. Les cicatrices rétractiles intéressent le genou et le creux poplité dans 47% des cas et le pied dans 45% des cas. Elles sont bilatérales dans 21% des cas, et concernent une autre localisation associée dans 21% des cas. Quant aux brides, 21% ont bénéficié d'une chirurgie, avec un délai moyen de 3 ans et 2 mois après la brûlure. Cette procédure chirurgicale consiste en une plastie en Z dans 91% des cas, à laquelle est associée une greffe de peau dans 54% des cas. Une rééducation fonctionnelle est pratiquée chez 54% des opérés. Parallèlement aux données de la littérature, nos résultats montrent que l'optimisation de la prise en charge passe par une meilleure prévention des accidents domestiques et une bonne codification thérapeutique. PMID:21991202

  20. Les carcinomes epidermoïdes du scrotum: à propos de 7 cas avec revue de la litterature

    PubMed Central

    Halfya, Ayoub; Elmortaji, Khalid; Redouane, Rabii; fethi, Meziane; Rafik, Amine; Mohamed, Ezzoubi; Abdessamad, Chlihi

    2015-01-01

    Quoique rare le carcinome épidermoïde du scrotum a un mauvais pronostic. Les Carcinomes du scrotum induite et - liées au travail sont moins fréquentes en raison d'une meilleure hygiène, vêtements de protection, et la sensibilisation de la cancérogénicité des huiles industrielles. L’épidémie à l'HPV a induit une augmentation de l'incidence. Le traitement de dépend toujours exérèse locale de la lésion primaire. La radiothérapie a peu de bénéfice thérapeutique dans le traitement d'un carcinome épidermoïde du scrotum. La bléomycine peut être utile comme traitement adjuvant pour les maladies ilio-inguinal généralisée avant la tentative exérèse, même si cela n'a pas encore été prouvé. Entre janvier 2011 au 1er janvier 2013, 7 patients atteints de carcinome épidermoïde ont été pris en charge, Trois patients ont présenté une localisation ganglionnaire. Les sept patients ont eu un traitement chirurgical par exérèse large avec reconstruction, Deux patients ont été adressé pour chimiothérapie.2 patients ont présenté une récidive, dont un est décédé. PMID:26113906

  1. Flow of ground water through fractured carbonate rocks in the Prairie du Chien-Jordan Aquifer, southeastern Minnesota

    USGS Publications Warehouse

    Ruhl, J.F.

    1989-01-01

    Contamination of groundwater from point and nonpoint sources (such as landfills, feedlots, agricultural chemicals applied to fields, and septic systems) is a recognized problem in the karst area of southeastern Minnesota. The US Geological Survey, in cooperation with the Minnesota Department of Natural Resources and the Legislative Commission on Minnesota Resources, Began a study in October 1987 to improve the understanding of local groundwater flow through karst terrain in southeastern Minnesota. The objectives of the study are to: (1) describe the orientations of systematic rock fractures and solution channels of the Prairie du Chien Group of Ordovician-age carbonate rocks in southeastern Minnesota, and, if possible, to define the principal and minor axes of these orientations; and (2) evaluate the effect of fractures and solution channels in the Prairie du Chien Group on the local flow of groundwater. Groundwater in the Upper Carbonate aquifer regionally flows toward the periphery of the aquifer and locally flows into streams and bedrock valleys. The hydraulic gradient in this aquifer generally is greatest near areas of groundwater seepage to streams. Regional groundwater flow in the Prairie du Chien-Jordan aquifer generally is to the south and east in much of Fillmore and Houston Counties and in the southern parts of Olmsted and Winona Counties. Groundwater seepage to selected streams was evaluated by current-meter measurements of downstream gains or losses of streamflow and by an experimental approach based on radon activity in streams. The activity of radon in groundwater ranges from two to four orders of magnitude greater than the activity in surface water; therefore, groundwater seepage to streams generally increases the in-stream radon activity.

  2. Niveau socioéconomique et processus du recours aux soins par les familles de patients souffrant de troubles psychiques au Burkina Faso

    PubMed Central

    Yaogo, Ahmed; Sommer, Alain; Moulaï, Pierre; Chebili, Saïd; Abaoub-Germain, Agnès

    2014-01-01

    Introduction Le Burkina Faso a connu une amélioration constante depuis deux décennies de l'offre de soins en psychiatrie. De même, le taux d'alphabétisation sans cesse croissant s'accompagne d'une profonde modification des conceptions et des comportements. La présente étude visait à déterminer l′impact des déterminants socioéconomiques sur le processus du recours aux soins par les familles. Méthodes Il s'est agi d'une enquête transversale portant sur 200 familles, menée dans le service de psychiatrie du Centre Hospitalier Universitaire Yalgado Ouédraogo de Ouagadougou. Variable à expliquer: premier recours aux soins par les familles (guérisseur traditionnel ou prières religieuses vs. consultations psychiatrique ou médicale). Variable explicative: catégorie socioprofessionnelle classée en suivant la nomenclature des professions et catégories socioprofessionnelles; niveau d’études. L'analyse statistique a été effectuée à l'aide du logiciel SAS version 9.2. Le test du Khi deux a été utilisé. Résultats Il existait une association entre le choix du premier recours et la Profession et la catégorie socioprofessionnelledu « décideur » (p = 0.0006) ainsi que leniveau d’études du « décideur » (p = 0.0001). Conclusion La Profession et Catégorie Sociale et le niveau d'instruction scolaire pourraient être un marqueur important dans les politiques visant à optimiser les processus de recours aux soins des patients dans le circuit de soins. PMID:25161751

  3. [Risk Assessment of Heavy Metal Contamination in Farmland Soil in Du'an Autonomous County of Guangxi Zhuang Autonomous Region, China].

    PubMed

    Wu, Yang; Yang, Jun; Zhou, Xiao-yong; Lei, Mei; Gao, Ding; Qiao, Peng-wei; Du, Guo-dong

    2015-08-01

    For a comprehensive understanding of the pollution characteristics and ecological risk of heavy metals of farmland soil in Du'an Autonomous County of Guangxi Zhuang Autonomous Region, China, this study evaluated the cadmium (Cd), arsenic (As), nickel (Ni), zinc (Zn), chromium (Cr), antimony (Sb), copper (Cu) and lead ( Pb) pollution situation using the single factor index, the Nemerow pollution index and the Hakanson ecological risk index. The results showed that heavy-metal pollution of farmland soil in Du'an County was serious. 74.6% of the soil samples had heavy metals concentrations higher than the Grade II of National Soil Environmental Quality Standard (GB 15618-1995). The over standard rates of Cd, As, Ni, Zn, Cr, Sb, Cu, Pb were 70.6%, 42.9%, 34.9%, 19.8%, 19.6%, 2.94%, 1.59%, 0.79%, respectively. Cd and As were the main contaminants in Du'an County, the pollution was far more serious than those of the national and Guangxi Zhuang Autonomous Region. In terms of the ecological risk, heavy metals of farmland soil in Du'an County showed a "middle" ecological risk, with Cd accounting for 88% of the total ecological risk. The north-west of Jiudu Town and the zone between Bao'an Town and Dongmiao Town were two areas with high ecological risk in Du'an County. The contamination of farmland soils in Du'an County was caused by two main sources, whereas the pollution of As and Sb of farmland soils near Diaojiang River was mainly caused by the upstream mining industry. PMID:26592028

  4. Identification of differentially expressed genes associated with the enhancement of X-ray susceptibility by RITA in a hypopharyngeal squamous cell carcinoma cell line (FaDu)

    PubMed Central

    Luan, Jinwei; Li, Xianglan; Guo, Rutao; Liu, Shanshan; Luo, Hongyu

    2016-01-01

    Abstract Background Next generation sequencing and bio-informatic analyses were conducted to investigate the mechanism of reactivation of p53 and induction of tumor cell apoptosis (RITA)-enhancing X-ray susceptibility in FaDu cells. Materials and methods The cDNA was isolated from FaDu cells treated with 0 X-ray, 8 Gy X-ray, or 8 Gy X-ray + RITA. Then, cDNA libraries were created and sequenced using next generation sequencing, and each assay was repeated twice. Subsequently, differentially expressed genes (DEGs) were identified using Cuffdiff in Cufflinks and their functions were predicted by pathway enrichment analyses. Genes that were constantly up- or down-regulated in 8 Gy X-ray-treated FaDu cells and 8 Gy X-ray + RITA-treated FaDu cells were obtained as RITA genes. Afterward, the protein-protein interaction (PPI) relationships were obtained from the STRING database and a PPI network was constructed using Cytoscape. Furthermore, ClueGO was used for pathway enrichment analysis of genes in the PPI network. Results Total 2,040 and 297 DEGs were identified in FaDu cells treated with 8 Gy X-ray or 8 Gy X-ray + RITA, respectively. PARP3 and NEIL1 were enriched in base excision repair, and CDK1 was enriched in p53 signaling pathway. RFC2 and EZH2 were identified as RITA genes. In the PPI network, many interaction relationships were identified (e.g., RFC2-CDK1, EZH2-CDK1 and PARP3-EZH2). ClueGO analysis showed that RFC2 and EZH2 were related to cell cycle. Conclusions RFC2, EZH2, CDK1, PARP3 and NEIL1 may be associated, and together enhance the susceptibility of FaDu cells treated with RITA to the deleterious effects of X-ray. PMID:27247549

  5. Les astronomes européens auscultent les cieux avec le plus grand télescope du monde

    NASA Astrophysics Data System (ADS)

    Malbet, F.

    2008-09-01

    À l'heure des projets de télescopes extrêmement grands, l'Europe a déjà une longueur d'avance. Le télescope européen (VLT), en mode interférométrique avec l'instrument AMBER devient le plus grand télescope jamais utilisé dans le domaine optique aussi bien en surface de miroir (plus de 150 m2) qúen finesse de résolution qui atteint celle d'un télescope de 130 m de diamètre. Le journal professionnel Astronomy & Astrophysics a publié en 2007 un numéro spécial qui rapporte les premiers résultats obtenus avec l'instrument AMBER (Astronomical MultiBEam Recombiner) par le très grand télescope européen. Ces articles couvrent pratiquement tous les stades de l'évolution stellaire depuis la formation des étoiles et des planètes jusqu'a l'observation de l'explosion de type nova dans un système stellaire évolué. Ces résultats inédits ont été obtenus en utilisant simultanément 3 des 4 télescopes du VLT basés à l'Observatoire européen austral du mont Paranal au Chili. L'instrument AMBER équipant le VLTI (mode interférométrique du VLT) permet dâatteindre une résolution angulaire inégalée de l'ordre du millième de seconde d'angle autorisant l'observation des astres dans différentes longueurs d'onde, dans l'infrarouge proche. Les astronomes obtiennent donc des observations avec une finesse 13 fois plus importante que celle d'un télescope seul. Il devient alors possible de sonder les régions de formation de planètes, d'observer les vents des étoiles en rotation très rapide, d'étudier les différents types de matières éjectées par une étoile massive, de séparer les deux composantes d'une étoile double serrée et de voir en direct l'évolution d'une nova quelques jours seulement après son explosion.

  6. Optical, mechanical and electronic design and integration of POMM, a polarimeter for the Observatoire du mont Mégantic

    NASA Astrophysics Data System (ADS)

    Leclerc, Melanie R.; Côté, Patrice; Duchesne, François; Bastien, Pierre; Hernandez, Olivier; Colonna d'Istria, Pierre; Demers, Mathieu; Girard, Marc; Savard, Maxime; Lemieux, Dany; Thibault, Simon; Brousseau, Denis

    2014-08-01

    A polarimeter, to observe exoplanets in the visible and infrared, was built for the "Observatoire du Mont Mégantic" (OMM) to replace an existing instrument and reach 10-6 precision, a factor 100 improvement. The optical and mechanical designs are presented, with techniques used to precisely align the optical components and rotation axes to achieve the targeted precision. A photo-elastic modulator (PEM) and a lock-in amplifier are used to measure the polarization. The typical signal is a high DC superimposed to a very faint sinusoidal oscillation. Custom electronics was developed to measure the AC and DC amplitudes, and characterization results are presented.

  7. Pharmacokinetics and tolerance of DU-6859a, a new fluoroquinolone, after single and multiple oral doses in healthy volunteers.

    PubMed Central

    Nakashima, M; Uematsu, T; Kosuge, K; Umemura, K; Hakusui, H; Tanaka, M

    1995-01-01

    The pharmacokinetics and tolerance of DU-6859a, 7-[(7S)-7-amino-5-azaspiro[2,4]heptan-5-yl]-8-chloro-6-fluor o-1-[(1R, 2S)-2-fluoro-1-cyclopropyl]-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid sesquihydrate, were investigated in healthy male Japanese volunteers after single (25, 50, 100, and 200 mg) and multiple (100 mg three times a day for 6 days plus once a day on the 7th day and 50 mg every 12 h for 13 doses) oral doses. DU-6859a was well tolerated at all doses, and all 36 subjects completed the study; mild transient soft stool in five volunteers and mild transient diarrhea in one volunteer on the multiple-dose (100 mg three times a day) study were the only side effects reported. No drug crystals were observed in the urine after the single 200-mg dose and the 100-mg three times a day regimen. DU-6859a was rapidly absorbed in the fasted state. The mean maximum concentration in serum (Cmax) ranged from 0.29 to 1.86 micrograms/ml for the 25- to 200-mg dose, and the mean time to reach Cmax ranged from 1.0 to 1.3 h. The terminal half-life ranged from 4.4 to 5.0 h. The area under the curve increased dose dependently. The serum protein binding of the drug was approximately 50%. The apparent volume of distribution clearly exceeded 1 liter/kg, suggesting good tissue penetration. Within 48 h, the cumulative urinary recovery of unchanged drug amounted to 69 to 74% of the dose administered, while fecal excretion up to 48 h after the 200-mg dose accounted for ca. 3% of the dose. Food intake did not affect the rate and extend of absorption of DU-6859a to a clinically significant extent. During multiple oral dosing, the accumulation of the drug in serum was close to the theoretically predicted values, which indicated that there was virtually no drug accumulation. PMID:7695301

  8. Le naevus bleu cellulaire atypique du poignet: à propos d'un cas et revue de la literature

    PubMed Central

    Boussakri, Hassan; Roux, Jean Luc; Durand, Luc; Elibrahimi, Abdelhalim; Elmrini, Abdelmajid

    2014-01-01

    Le naevus bleu cellulaire atypique est une entité pathologique rare et sa localisation au niveau du poignet est exceptionnelle. Il est Considéré comme une Variante à des caractéristiques intermédiaires entre le naevus bleu cellulaire typique et le naevus bleu malin, dont l’évolution est incertaine. Le but de notre travail est d'attirer l'attention sur cette variété lésionnelle rare et de discuter les diagnostiques différentiels, ainsi que décrire les aspects histologique et les options thérapeutiques possibles. PMID:25426206

  9. Carl Ludwig, Jacob Henle, Hermann Helmholtz, Emil DuBois-Reymond and the scientific development of nephrology in Germany.

    PubMed

    Hierholzer, K

    1994-01-01

    Medical science in the 2nd half of the 19th century proceeded in a stepwise fashion, when the development of new techniques permitted the evaluation of living processes by direct microscopic or endoscopic inspection, as well as by quantitative measurements of the underlying physical and chemical forces. Ludwig, Henle, Helmholtz and DuBois-Reymond all contributed in different ways to the evolution of medicine and physiology into natural sciences, freed from romantic, philosophic speculation. Nephrology benefitted from this development and from the contributions of the non-nephrologists to natural science. PMID:7847467

  10. Identification des risques professionnels dans l'industrie textile en République Démocratique du Congo

    PubMed Central

    Kitronza, Panda Lukongo

    2014-01-01

    Introduction Le but de cette étude est de mettre en évidence les facteurs de risques professionnels liés aux conditions de travail. Méthodes Cette étude qualitative basée sur les entretiens de groupe a été réalisée par une équipe pluridisciplinaire dans l'industrie textile de la région du Est de la RDC; comprenant un médecin de travail, un médecin de santé publique, un toxicologue, deux infirmiers du centre hospitalier de l'usine, un représentant du comité d'hygiène et un technicien de prévention. La démarche méthodologique a consisté en des entretiens en groupe, des observations et visites guidées de lieux de travail de l'entreprise. Résultats Dans la culture du coton, les effets d'une forte exposition aux pesticides peuvent entraîner des intoxications aiguës, chroniques et voire le décès. Les autres risques sont les accidents de travail, les maladies professionnelles, les troubles psychologiques. Dans l'industrie, les travailleurs sont exposés aux risques liés à l'empoussiérage des fibres de coton, aux facteurs des risques traumatiques, physiques (bruits, vibration) et chimiques (acides forts, bases fortes, solvants et colorants minéraux), ainsi qu'aux risques psychosociaux. La pollution de l'environnement et l’écotoxicité inhérente à ces activités restent l'effet de l'usage des grandes quantités d'intrants agricoles, engrais et produits phytosanitaires. Conclusion Cette étude a permis de mettre en évidence les différents facteurs de risques auxquelles sont soumis les travailleurs textiles; ainsi que les risques environnementaux liés à cette activité. Cela est de nature à permettre la mise sur pied d'une stratégie efficace de prévention et de protection des travailleurs. PMID:25977736

  11. Panniculite au cours d'un traitement d'une dermatomyosite par du méthotrexate

    PubMed Central

    Feki, Nabil Bel; Khanfir, Monia Smiti; Ghorbel, Imed Ben; Said, Fatma; Houman, Mohamed Habib

    2016-01-01

    La panniculite est une manifestation rare au cours des dermatomyosites (DM). L'apparition d'une panniculite au cours d'un traitement par du méthotrexate (MTX) est exceptionnelle et n'a été décrite que dans 3 cas. Nous rapportons l'observation d'une patiente âgée de 50 ans atteinte d'une DM diagnostiquée en 1997 et traitée par une corticothérapie avec une évolution favorable aux plans clinique et biologique. A l'occasion d'une rechute 2 ans plus tard, la corticothérapie a été majorée et du méthotrexate à une dose hebdomadaire de 7,5 mg a été rajouté. L’évolution était rapidement favorable. Dix huit mois plus tard, la patiente présentait de multiples nodules sous cutanés siégeant aux 4 membres et aux fesses, dont l'examen anatomopthologique concluait à une panniculite. Il n'existait aucun signe d’évolutivité de la DM. La dose de prédnisone a été augmentée à 0,5 mg/kg/j toujours en association au MTX mais sans aucune amélioration. Le MTX a été arrêté et les lésions cutanées ont complètement disparu en 2 mois sans aucune récidive avec un recul actuel de 42 mois. Notre observation est particulière par la survenue d'une panniculite chez une patiente ayant une DM traitée par du MTX et illustre la difficulté diagnostique. Cette entité doit être connue malgré son caractère exceptionnel puisque l'arrêt du MTX induit en général la disparition des nodules sous cutanés. PMID:27279974

  12. Dermatomyosite du sujet âgé: étude de 4 observations dans le sud tunisien

    PubMed Central

    Frikha, Faten; Snoussi, Mouna; Salah, Raida Ben; Saidi, Noura; Kaddour, Neila; Bahloul, Zouhir

    2012-01-01

    La dermatomyosite (DM) touche essentiellement l’adolescent et l’adulte jeune, elle est très rare chez le sujet âgé, le plus souvent associée à des complications iatrogènes et à une pathologie cancéreuse. Nous avons étudié les caractéristiques de la DM du sujet âgé à travers une étude rétrospective dans laquelle nous avons comparé 4 patients âgés de plus de 65 ans au début de la myosite avec 40 sujets jeunes. PMID:23308331

  13. Identification of ryanodine receptor isoforms in prostate DU-145, LNCaP, and PWR-1E cells.

    PubMed

    Kobylewski, Sarah E; Henderson, Kimberly A; Eckhert, Curtis D

    2012-08-24

    The ryanodine receptor (RyR) is a large, intracellular calcium (Ca(2+)) channel that is associated with several accessory proteins and is an important component of a cell's ability to respond to changes in the environment. Three isoforms of the RyR exist and are well documented for skeletal and cardiac muscle and the brain, but the isoforms in non-excitable cells are poorly understood. The aggressiveness of breast cancers in women has been positively correlated with the expression of the RyR in breast tumor tissue, but it is unknown if this is limited to specific isoforms. Identification and characterization of RyRs in cancer models is important in understanding the role of the RyR channel complex in cancer and as a potential therapeutic target. The objective of this report was to identify the RyR isoforms expressed in widely used prostate cancer cell lines, DU-145 and LNCaP, and the non-tumorigenic prostate cell line, PWR-1E. Oligonucleotide primers specific for each isoform were used in semi-quantitative and real-time PCR to determine the identification and expression levels of the RyR isoforms. RyR1 was expressed in the highest amount in DU-145 tumor cells, expression was 0.48-fold in the non-tumor cell line PWR-1E compared to DU-145 cells, and no expression was observed in LNCaP tumor cells. DU-145 cells had the lowest expression of RyR2. The expression was 26- and 15-fold higher in LNCaP and PWR-1E cells, respectively. RyR3 expression was not observed in any of the cell lines. All cell types released Ca(2+) in response to caffeine showing they had functional RyRs. Total cellular RyR-associated Ca(2+) release is determined by both the number of activated RyRs and its accessory proteins which modulate the receptor. Our results suggest that the correlation between the expression of the RyR and tumor aggression is not related to specific RyR isoforms, but may be related to the activity and number of receptors. PMID:22846571

  14. Brulures Profondes des Membres Apres Intoxication au Co Par Usage du Barbecue Traditionnel en Salle de Bain

    PubMed Central

    Chraïbi, R.; Moussaoui, A.; Tourabi, K.; Ennouhi, A.; Ihrai, H.; Hassam, B.

    2007-01-01

    Summary En l'absence des moyens de chauffage moderne à domicile chez une proportion non négligeable des Marocains, le recours au moyen traditionnel est fréquent. A travers six observations de brûlures profondes des membres, particulières par leur mode de survenue et par leur gravité, les Auteurs attirent l'attention sur le danger de l'utilisation du barbecue traditionnel «majmer» pour réchauffement en milieu clos. PMID:21991072

  15. Reconstruction de la surface de Fermi dans l'etat normal d'un supraconducteur a haute Tc: Une etude du transport electrique en champ magnetique intense

    NASA Astrophysics Data System (ADS)

    Le Boeuf, David

    Des mesures de resistance longitudinale et de resistance de Hall en champ magnetique intense transverse (perpendiculaire aux plans CuO2) ont ete effectuees au sein de monocristaux de YBa2Cu3Oy (YBCO) demacles, ordonnes et de grande purete, afin d'etudier l'etat fondamental des supraconducteurs a haute Tc dans le regime sous-dope. Cette etude a ete realisee en fonction du dopage et de l'orientation du courant d'excitation J par rapport a l'axe orthorhombique b de la structure cristalline. Les mesures en champ magnetique intense revelent par suppression de la supraconductivite des oscillations magnetiques des resistances longitudinale et de Hall dans YBa2Cu 3O6.51 et YBa2Cu4O8. La conformite du comportement de ces oscillations quantiques au formalisme de Lifshitz-Kosevich, apporte la preuve de l'existence d'une surface de Fermi fermee a caractere quasi-2D, abritant des quasiparticules coherentes respectant la statistique de Fermi-Dirac, dans la phase pseudogap d'YBCO. La faible frequence des oscillations quantiques, combinee avec l'etude de la partie monotone de la resistance de Hall en fonction de la temperature indique que la surface de Fermi d'YBCO sous-dope comprend une petite poche de Fermi occupee par des porteurs de charge negative. Cette particularite de la surface de Fermi dans le regime sous-dope incompatible avec les calculs de structure de bande est en fort contraste avec la structure electronique presente dans le regime surdope. Cette observation implique ainsi l'existence d'un point critique quantique dans le diagramme de phase d'YBCO, au voisinage duquel la surface de Fermi doit subir une reconstruction induite par l'etablissement d'une brisure de la symetrie de translation du reseau cristallin sous-jacent. Enfin, l'etude en fonction du dopage de la resistance de Hall et de la resistance longitudinale en champ magnetique intense suggere qu'un ordre du type onde de densite (DW) est responsable de la reconstruction de la surface de Fermi. L'analogie de

  16. Modélisation du cycle de vie d'un polluant en atmosphère : application aux oxydes d'azote (NO{X})

    NASA Astrophysics Data System (ADS)

    Hamzi, R.; Bourmada, N.; Benamrane, B. T.; Londiche, H.

    2005-05-01

    Les problèmes de l'environnement nécessitent des modélisations particulièrement difficiles, mais d'une grande importance sociale. C'est un domaine récent, où les données sont encore peu nombreuses, mais où les attentes sont considérables, tant auprès du public que des politiques et des industriels. En effet, la modélisation consiste à définir un modèle qui permettra de représenter efficacement le processus étudié. Dans cette optique le comportement modélisé n'est que la manifestation extérieure d'une structure plus profonde. La complexité du système et du problème posé détermine celle du modèle, qui va de la simple représentation qualitative d'un comportement aux formules mathématiques les plus élaborées. Lorsque la modélisation est exprimée mathématiquement, on recourt généralement à un programme de simulation pour calculer le comportement prévisionnel du modèle. La compréhension du cycle de vie d'un polluant en atmosphère, dans notre cas les oxydes d'azote (NOX), nécessite la modélisation de l'évolution des réactifs et des produits en fonction du temps exprimée par des équations différentielles. La réalisation de la simulation à partir de ces modèles, nous permet de connaître l'ensemble des processus ayant lieu lors de l'émission du polluant en atmosphère jusqu'à sa consommation.

  17. Luxation latente isolée du scaphoïde carpien chez l'enfant: à propos d'un cas

    PubMed Central

    Nader, Youssef; Koulali, Khalid Idrissi

    2015-01-01

    La luxation isolé du scaphoïde carpien est une lésion rare en particulier chez l'enfant, passant d'autant plus facilement inaperçue que le squelette du carpe est moins ossifié, dans cette observation ici rapportée, ou le diagnostic fut tardif, L'I.R.M. permet de reconnaitre la lésion, traitée par réduction chirurgicale que les auteurs considèrent essentielle même distance de la lésion. PMID:26113918

  18. Measurements of daily urinary uranium excretion in German peacekeeping personnel and residents of the Kosovo region to assess potential intakes of depleted uranium (DU).

    PubMed

    Oeh, U; Priest, N D; Roth, P; Ragnarsdottir, K V; Li, W B; Höllriegl, V; Thirlwall, M F; Michalke, B; Giussani, A; Schramel, P; Paretzke, H G

    2007-08-01

    Following the end of the Kosovo conflict, in June 1999, a study was instigated to evaluate whether there was a cause for concern of health risk from depleted uranium (DU) to German peacekeeping personnel serving in the Balkans. In addition, the investigations were extended to residents of Kosovo and southern Serbia, who lived in areas where DU ammunitions were deployed. In order to assess a possible DU intake, both the urinary uranium excretion of volunteer residents and water samples were collected and analysed using inductively coupled plasma-mass spectrometry (ICP-MS). More than 1300 urine samples from peacekeeping personnel and unexposed controls of different genders and age were analysed to determine uranium excretion parameters. The urine measurements for 113 unexposed subjects revealed a daily uranium excretion rate with a geometric mean of 13.9 ng/d (geometric standard deviation (GSD)=2.17). The analysis of 1228 urine samples from the peacekeeping personnel resulted in a geometric mean of 12.8 ng/d (GSD=2.60). It follows that both unexposed controls and peacekeeping personnel excreted similar amounts of uranium. Inter-subject variation in uranium excretion was high and no significant age-specific differences were found. The second part of the study monitored 24 h urine samples provided by selected residents of Kosovo and adjacent regions of Serbia compared to controls from Munich, Germany. Total uranium and isotope ratios were measured in order to determine DU content. (235)U/(238)U ratios were within +/-0.3% of the natural value, and (236)U/(238)U was less than 2 x 10(-7), indicating no significant DU in any of the urine samples provided, despite total uranium excretion being relatively high in some cases. Measurements of ground and tap water samples from regions where DU munitions were deployed did not show any contamination with DU, except in one sample. It is concluded that both peacekeeping personnel and residents serving or living in the Balkans

  19. Kyste hydatique du foie rompu dans la paroi abdominale et dans le muscle psoas : à propos d'une rare observation

    PubMed Central

    En-Nafaa, Issam; Moujahid, Mountassir; Alahyane, Abdelouahabe; Amil, Touria; Hanine, Ahmed; Ziadi, Tarik

    2011-01-01

    Le kyste hydatique du foie est une parasitose qui sévit à l′état endémique au maroc. La rupture dans la paroi abdominale et dans le psoas est une complication exceptionnelle. Nous rapportons un cas de kyste hydatique du foie rompu dans la paroi et dans le muscle psoas. Le diagnostic a été établi sur les données de l′échographie et surtout de la tomodensitométrie. Le patient a été opéré avec des suites simples. PMID:22187585

  20. Mise en évidence d'états excités dans les spectres de photoionisation du cyclohexane et du diméthyl 2-2-butane liquides

    NASA Astrophysics Data System (ADS)

    Casanovas, J.; Guelfucci, J. P.; Caselles, O.

    1991-07-01

    Excited states are probably occurring, at an intermediate stage, in the VUV photoionization process of liquid hydrocarbons, as suggested by a Stern-Volmer behaviour when interacting with electron quenchers. They are here detected in the VUV photoionization spectrum of cyclohexane and dimethyl-2-2-butane in liquid phase. Some of the discernable peaks can be assigned as valence and Rydberg states, yet observed in gas phase. Supplementary peaks are observed, the existence of which is to be interpretated. L'existence d'états excités dans le processus de photoionisation VUV des hydrocarbures en phase liquide - précédemment suggérée par l'observation de la loi de Stern-Volmer lors de l'interaction avec des capteurs d'électrons - est ici détectée en traçant le spectre de photoionisation VUV du cyclohexane et du diméthyl-2-2-butane purs en phase liquide. Certains des pics observés coïncident avec les états de valence et de Rydberg de ces mêmes corps en phase gaz. Il apparaît des pics supplémentaires dont la nature doit être précisée.