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1

Quels outils de pilotage stratégique pour les entreprises innovantes : le cas du centre de recherche intégré MIRCen (CEA) ?  

Microsoft Academic Search

A l'heure des pôles de compétitivité, l'innovation est considérée comme un facteur clé de succès des entreprises. Mais qu'en est-il réellement du pilotage stratégique des entreprises innovantes ? Il existe à ce jour peu d'outils réellement adaptés à ce type d'entreprises, dont la production principale est la production de connaissances et de compétences nouvelles. Nous proposons dans cet article un

Aude Schindler; Aurélie Dudezert

2007-01-01

2

CEA-Related CAMs.  

PubMed

The carcinoembryonic antigen (CEA) family comprises a large number of cellular surface molecules, the CEA-related cell adhesion molecules (CEACAMs), which belong to the Ig superfamily. CEACAMs exhibit a complex expression pattern in normal and malignant tissues. The majority of the CEACAMs are cellular adhesion molecules that are involved in a great variety of distinct cellular processes, for example in the integration of cellular responses through homo- and heterophilic adhesion and interaction with a broad selection of signal regulatory proteins, i.e., integrins or cytoskeletal components and tyrosine kinases. Moreover, expression of CEACAMs affects tumor growth, angiogenesis, cellular differentiation, immune responses, and they serve as receptors for commensal and pathogenic microbes. Recently, new insights into CEACAM structure and function became available, providing further elucidation of their kaleidoscopic functions. PMID:20455097

Horst, A K; Wagener, C

2004-01-01

3

LE CHANGEMENT ORGANISATIONNEL DES CABINETS COMPTABLES LIBERAUX INDUIT PAR LES EVOLUTIONS DU REFERENTIEL COMPTABLE  

Microsoft Academic Search

1er Janvier 2005 : A partir de cette date, les sociétés cotées en Europe et établissant des comptes consolidés ont l'obligation d'adopter le référentiel IFRS (International Financial Reporting Standards). Quant aux entités économiques non cotées, elles appliqueront pour les exercices comptables ouverts à partir du 1 Janvier 2005 deux nouveaux règlements comptables. L'introduction du référentiel IFRS entraîne de profonds changements

Christian Prat Dit Hauret; Jocelyn Husser

2006-01-01

4

BIQSFP 13 CEA Study Checklist  

Cancer.gov

Biomarker, Imaging, & QOL Studies Funding Program (BIQSFP) Study Checklist for Randomized Phase 3 Clinical Trials with a Comparator Arm and Cost-Effectiveness Analysis (CEA) Component INSTRUCTIONS: Please submit a response to each of the elements

5

Evolution des quasiparticules nodales du cuprate supraconducteur YBa2Cu3Oy en conductivite thermique  

NASA Astrophysics Data System (ADS)

Ce memoire presente des mesures de conductivite thermique sur les supraconducteurs YBCO et Tl-2201 afin de statuer sur la presence possible d'un point critique quantique (QCP) dans le diagramme de phase de cuprates. Ce point critique quantique serait a l'origine de la reconstruction de la surface de Fermi, d'un large cylindre de trous en de petites poches de trous et d'electrons. La conductivite thermique dans le regime T ? 0 permet d'extraire une quantite purement electronique liee aux vitesses de Fermi et du gap, au noeud. Une discontinuite dans cette quantite pourrait signaler la traversee du dopage critique qui reconstruit la surface de Fermi. Plusieurs sondes experimentales distinguent une transition de phase ou un crossover a T* a temperature finie. D'autres sondes mettent en evidence une transition de phase sous l'effet d'un champ magnetique. La presence ou non de cet ordre, a temperature et champ magnetique nul questionne la communaute depuis plusieurs annees. Dans cette etude, nous detectons une variation brusque de kappa0/T a p = 0.18 dans YBCO et a p = 0.20 dans Tl-2201. Ces sauts sont interpretes comme un signe de la transition a temperature nulle et sont en faveur d'un QCP. Le manque de donnees d'un meme materiau a ces dopages ne permet pas de valider hors de tout doute l'existence d'un point critique quantique. Le modele theorique YRZ decrit aussi bien les donnees de conductivite thermique. Des pistes de travaux experimentaux a poursuivre sont proposees pour determiner la presence ou non du QCP de facon franche. Mots-cles : Supraconducteurs, cuprates, conductivite thermique, point critique quantique.

Rene de Cotret, Samuel

6

CEA electric water heating manual  

Microsoft Academic Search

The Canadian Electric Association (CEA) has prepared an electric water heating manual for its customers. It is an easy-to-use reference manual for those who are interested in residential, commercial, or industrial water heaters. The book contains five chapters, of which we are reviewing the first two (the last three focus on commercial and industrial applications). An appendix on research and

Lebot

1988-01-01

7

How Packaging Fleet Renewal Fits French CEA Programs  

SciTech Connect

CEA's (French Atomic Energy Agency) packaging fleet is dedicated to transportation of test irradiated fuels, of research reactors fuels, of navy propulsion fuels, and of waste coming from and to nuclear plants or facilities. This fleet encompasses more than 30 types of casks ranging from 5 to 30 tons, with either recent designs or other dating back to the seventies. A study has been launched in order to perform a global analysis of the life expectancy of the existing CEA and COGEMA Logistics cask fleets with respect to a 2015 target, in order to anticipate its renewal, while limiting the number of type of cask. Key elements like periodical evolutions of design and transport regulations, lessons learnt of existing casks (design, approval and extensions, operational feedback, maintenance and dismantling) are taken into account in order to ensure compliance and availability of the fleet. Moreover, from design to cask delivery, including regulatory tests, safety analysis report/ CoC, and manufacturing, 3 to 5 years is needed. Therefore cask development should be taken into account earlier of invest and research's programs. The paper will address the current life expectancy study of CEA and COGEMA Logistics packaging fleet, based on lessons learnt and regulation evolution and on general R and D plans by user facilities. It will show how a comprehensive optimized fleet is made available to CEA and other customers. Such a fleet combines optimized investment and uses, thus entailing synergies for well-mastered costs of transports. (authors)

Dumesnil, J.; Malvache, P. [Commissariat a l'Energie Atomique - CEA (France); Hugon, F.C.; Sollacaro, M. [COGEMA LOGISTICS - AREVA Group (France)

2006-07-01

8

Etude de l'evolution thermique du dommage d'implantation dans le silicium par nanocalorimetrie  

NASA Astrophysics Data System (ADS)

The subject of the present thesis is the thermal annealing of damage produced by low energy implantation of silicon, using for the first time the nanocalorimetry technique. This technique works following similar principles as differential scanning calorimetry, but the small addenda and the high temperature scanning rate make the technique orders of magnitude more sensitive to low energy (?30 keV), low fluence (<1012 at/cm2) implantations, and can be used in-situ, opening the door to low temperature measurements. Nanocalorimetry measurements showed that the kinetics of the heat release during the annealing of ion-implanted poly-Si is independent of fluence and energy. This strongly suggests that most of the rate of heat released during the annealing can be described as a process internal to the damage zones produced by each ion. The heat release uniformity shows that the process goes through a large variety of steps, and can be explained by the fact that the annealing kinetics primarily depends on the details of the damage zone interface to the surrounding crystal. We showed also that the total heat saturates around 4 x 1014 ions/cm2, which is consistent with other measurements made by Raman spectrometry and reflectometry performed on implanted polycrystalline silicon in the same conditions. However, RBS measurement show that we are far from complete amorphisation even at 8 x 1014 ions/cm2. The nanocalorimetry measurements at low temperature showed that poly-Si and a-Si are similar from the damage accumulation point of view. This was supported by reflectometry measurements performed on both materials implanted in the same conditions. Keywords. silicon, ion implantation, annealing, damage evolution, nanocalorimetry, silicon nitride membranes.

Karmouch, Rachid

9

BIQSFP_13_CEA_Study_Checklist  

Cancer.gov

Biomarker, Imaging, & QOL Studies Funding Program (BIQSFP) ’13 Study Checklist for Randomized Phase 3 Clinical Trials with a Comparator Arm and Cost-Effectiveness Analysis (CEA) Component INSTRUCTIONS: Please submit a response to each of the criteria

10

Short and long term evolution of deep giant submarine dunes in continental shelf environment: the example of the 'Banc du Four' (Western Brittany, France)  

NASA Astrophysics Data System (ADS)

The deep sandwave dynamics is still in debate. Understanding the migration processes and the resulting evolution of their 3D internal architecture are scientifically challenging. To address these questions we realized two swath bathymetry surveys complemented with seismic reflection across the large sandwaves field named 'Banc du Four'. It is located offshore the Western Brittany and is composed of more 500 dunes. Some of the dunes' wavelengths and heights exceed 1000m and 30m respectively placing them among the largest dunes ever described. Equilibrium laws obtained from our morphological analysis are not completely in agreement with those described in previous studies of similar structures in shallow waters. Relatively high migration velocities on deep continental shelves (from 3 to 20m.yr-1) attest of their still present dynamical equilibrium. Internal-external morphological and kinematical analyses show the existence of two different dynamic regimes. Interpretation of the seismic reflection data allowed reconstructing long-term evolution of the sandbank and the establishment of progressive connections between stepped submarine channels and tidal dynamics during the last sea-level rise.

Franzetti, M.; Le Roy, P.; Garlan, T.; Delacourt, C.; Thibaud, R.; Cancouet, R.; Graindorge, D.; Prunier, C.; Sukhovich, A.; Deschamps, A.

2013-12-01

11

CEA-LETI As A European Model Of Cooperation In Nanoelectronics  

NASA Astrophysics Data System (ADS)

The nanoelectronic industry is facing a major change. It induces significant evolutions in the way R&D is conducted worldwide. Europe developed specific models of cooperation. Among them CEA-LETI promotes the collaborative proximity with manufacturing sites and academia in the Grenoble area (France). This paper will detail this evolution of the nanoelectronic industry, how it induces renewed R&D models and how it affects the nanocharacaterization needs and methods.

Brillouët, Michel

2007-09-01

12

The Evolution of the Industrial Vehicle by the Year 2000 l'Evolution du Vehicule Industriel a l'Horizon 2000.  

National Technical Information Service (NTIS)

The possible evolution, if not probable, of those constraints which affect the design and use of tractor trucks is reviewed. These constraints include energy requirements, environmental codes, safety and security, reliability, and working conditions for t...

P. Soret

1980-01-01

13

BIQSFP_13_CEA_Study_Evaluation_Guidelines  

Cancer.gov

Cost-Effectiveness Analysis (CEA) Studies Funding Program Purpose and Background As part of its Prioritization and Scientific Quality Initiatives, the Clinical Trials Working Group (CTWG) of NCI recommended establishing a funding mechanism and prioritization process for essential correlative biomarker, imaging, and QOL studies that are incorporated into the fundamental design of a clinical trial.

14

Acute-phase reactant protein profiles: an aid to monitoring large bowel cancer by CEA and serum enzymes  

Microsoft Academic Search

The profiles of 4 acute-phase reactant proteins (APRPs) (haptoglobin (HPT), alpha1 antitrypsin (AAT), alpha1 acid glycoprotein (AGP) and prealbumin (PALB)) have been studied during the evolution of bowel cancer. Serial measurements of these APRPs can add to the information obtained from measurements of the level of CEA and hepatic enzymes during the monitoring of postoperative patients. There is considerable stability

A M Ward; E H Cooper; R Turner; J A Anderson; A M Neville

1977-01-01

15

Carcinoembryonic antigen (CEA) in diagosis and prognosis of colorectal carcinoma  

Microsoft Academic Search

An attempt is made to define the usefulness and limitations of carcinoembyonic antigen (CEA) radioimmunoassay for evaluation\\u000a of diagnosis, tumor resection, and detection of tumor relapse in 108 patients with colorectal carcinoma. Preoperative CEA\\u000a levels were correlated with pathologic stage and tumor localizations. Increasing levels of CEA were found with the advanced\\u000a stage of the disease (stage C and D

J. P. Arnaud; C. Koehl; M. Adloff

1980-01-01

16

Circulating CEA levels in patients with fulminant hepatitis  

Microsoft Academic Search

CEA levels were determined in blood specimens from 14 persons suffering from fulminant hepatitis. Values ranged from 1.9 to 21 ng\\/ml with a mean of 7.0 ng\\/ml. All except one patient had a CEA level greater than 2.5 ng\\/ml, but only three exceeded 10 ng\\/ml. There was no correlation between single CEA levels and prognosis, routine liver chemistries, or histopathologic

P. K. George; M. S. Loewenstein; M. J. O'Brien; B. Bronstein; R. S. Koff; N. Zamcheck

1982-01-01

17

Metastatic breast cancer with constantly low CEA blood levels  

Microsoft Academic Search

The capability of breast cancer to secrete CEA might have biological significance. In 105 patients with metastatic breast cancer serial CEA determinations and clinical follow-up data were available during progression of disease up to death. In this series, 39 patients (37%) had constantly low CEA levels (P=0.001) after mastectomy (39 versus 65 months) and after recurrence (18 versus 28 months)

G. Krieger; H.-E. Wander; M. Kneba; M. Prangen; G. Bandlow; G. A. Nagel

1984-01-01

18

Processus mis en jeu dans l'evolution morpho-dynamique de Roberts Bank (Delta du Fraser): Observation et modelisation hydrodynamiques et sedimentaires  

NASA Astrophysics Data System (ADS)

Roberts Bank couvre le delta intertidal entre le bras principal du fleuve Fraser et la pointe du Cap Roberts en Colombie Britannique, Canada. Sous la pression du developpement urbain et la modification du regime sedimentaire, cette plage de sable fin est soumise a une erosion significative. L'identification des forces hydrodynamiques, leur importance et leur interaction permettent de determiner les zones de transport, et donc la stabilite de Roberts Bank. Deux periodes de mesures associees a des phases de modelisation de la houle et des courants ont ete effectuees lors de ce travail. La premiere periode de mesure, entre le 29 juin et le 8 juillet 2001, a permis l'identification de processus hydrodynamiques et sedimentaires associes aux forts courants de maree presents le long de Roberts Bank. La seconde phase de mesure, entre le 1er mars et le 26 mars 2002, a permis d'etudier les processus de remise en suspension associes a la houle. Des phases de modelisation ont ete menees a partir des connaissances acquises sur le terrain, afin d'affiner la comprehension des processus sedimentaires et notamment les interactions houle - courant - sediment. Les mecanismes, mis en evidence dans cette etude, participent au faconnage de Roberts Bank, contribuent a son erosion et a la mise en place de nouvelles structures sedimentaires. Les courants de flot de maree vont initier la creation de nuages de resuspension de sediment depuis le fond. En eau peu profonde, la composante " onshore" du courant de maree induit un transport a la cote, tandis qu'en eau plus profonde une faible composante " offshore" du courant peut favoriser un transport au large le long de la pente. Les chenaux, les dunes subaquatiques et les surfaces d'erosion affleurantes fournissent une rugosite de fond suffisante a la generation de turbulence et donc de nuages de sediment en suspension. Lors de la maree de jusant, les sediments resuspendus en eau peu profonde, sont transportes vers le large a partir d'un panache de surface et par les chenaux deltaiques. Une forte turbulence favorisera un processus dit de "sedimentation convective induite par un melange turbulent" ("mixing-induced convective sedimentation "). Le comportement des vagues de tempete qui se propagent sur la partie superieure de la pente du Delta du Fraser depend du marnage, de l'incidence de propagation et de la morphologie sous-marine. Ces facteurs controlent une divergence dans le transport sedimentaire au niveau de la rupture de pente deltaique. A maree haute, le transport sedimentaire sera essentiellement "onshore".

Meule, Samuel

19

Update on Ignition Studies at CEA  

NASA Astrophysics Data System (ADS)

In the frame of the ICF Program at CEA with the Laser Megajoule (LMJ) we sum up our main results regarding experimental results obtained with the Omega laser (DOE collaboration): they concern some implosions of capsules filled with D2+Ar, the diagnostics are the core images with temporal resolution and the radiograph (symmetry study). On the other hand, the hydro-instability experiments are devoted to the study of the interplay of 2 perturbation modes and 3D perturbations. As far as the target design is concerned, we are extending the LMJ domain of operations to low laser energy.

Holstein, Pierre-Andre

2006-10-01

20

Gfr Core Neutronics Studies at CEA  

NASA Astrophysics Data System (ADS)

The Gas cooled Fast Reactor (GFR) is a high priority in the CEA R&D program on Future Nuclear Energy Systems. After preliminary neutronics and thermo-aerolic studies, a first He-cooled 2400MWth core design based on a series of carbide CERCER plates arranged in an hexagonal wrapper were selected. Although GFR subassembly and core design studies are still at an early stage of development, it is nonetheless possible to identify a number of nuclear data needs that could have some impact on the actual design: new materials, decay heat contributors….

Bosq, J. C.; Brun-Magaud, V.; Rimpault, G.; Tommasi, J.; Conti, A.; Garnier, J. C.

2006-04-01

21

Phase I trial of a recombinant yeast-CEA vaccine (GI-6207) in adults with metastatic CEA-expressing carcinoma.  

PubMed

Yeast-CEA (GI-6207) is a therapeutic cancer vaccine genetically modified to express recombinant carcinoembryonic antigen (CEA) protein, using heat-killed yeast (Saccharomyces cerevisiae) as a vector. In preclinical studies, yeast-CEA induced a strong immune response to CEA and antitumor responses. Patients received subcutaneous vaccines every 2 weeks for 3 months and then monthly. Patients were enrolled at 3 sequential dose levels: 4, 16, and 40 yeast units (10(7) yeast particles/unit). Eligible patients were required to have serum CEA > 5 ng/mL or > 20 % CEA(+) tumor block, ECOG PS 0-2, and no history of autoimmunity. Restaging scans were performed at 3 months and then bimonthly. Peripheral blood was collected for the analysis of immune response (e.g., by ELISPOT assay). Twenty-five patients with metastatic CEA-expressing carcinomas were enrolled. Median patient age was 52 (range 39-81). A total of 135 vaccines were administered. The vaccine was well tolerated, and the most common adverse event was grade 1/2 injection-site reaction. Five patients had stable disease beyond 3 months (range 3.5-18 months), and each had CEA stabilization while on-study. Some patients showed evidence post-vaccination of increases in antigen-specific CD8(+) T cells and CD4(+) T lymphocytes and decreases in regulatory T cells. Of note, a patient with medullary thyroid cancer had substantial T cell responses and a vigorous inflammatory reaction at sites of metastatic disease. Yeast-CEA vaccination had minimal toxicity and induced some antigen-specific T cell responses and CEA stabilization in a heterogeneous, heavily pre-treated patient population. Further studies are required to determine the clinical benefit of yeast-CEA vaccination. PMID:24327292

Bilusic, Marijo; Heery, Christopher R; Arlen, Philip M; Rauckhorst, Myrna; Apelian, David; Tsang, Kwong Y; Tucker, Jo A; Jochems, Caroline; Schlom, Jeffrey; Gulley, James L; Madan, Ravi A

2014-03-01

22

Simplifying CEA through Excel, VBA, and Subeq  

NASA Technical Reports Server (NTRS)

Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet. To implement this onto the Internet, I will need to develop an XML input/output format and learn how to write HTML.

Foster, Ryan

2004-01-01

23

Evolution  

NSDL National Science Digital Library

This virtual evolution exhibit at the University of California at Berkeley (Museum of Paleontology) combines several of the best resources we've evaluated, such as Phylogenetic Systematics and the Talk Origins Archive, among others. In addition, the Evolution Website provides information on the Theory of Evolution (with links to further information including Timeline of Evolutionary Thought; Systematics; Dinosaur Discoveries; and Vertebrate Flight) and the History of Evolutionary Thought (including dozens of biographical summaries). For educators or students interested in reviewing or learning about evolution in a historical context, this Website will be of much use.

24

Bolometers at CEA: ARTEMIS and beyond  

NASA Astrophysics Data System (ADS)

ArTeMiS is a bolometer camera that will be installed at the APEX submillimeter telescope in Chile in 2010. This instrument will be a powerful tool for scientists with its three focal planes that will operate simultaneously in background limited conditions at 200, 350 and 450 microns (5760 pixels in total). A prototype called p-ArTeMiS has been tested at APEX in 2007 and thanks to its good performances, the team has been able to conduct scientific projects in star formation and on debris disks. This paper summarises the details of the ArTeMiS project, with a description of the detectors, the optics, the cryogenics and the electronics. We will also present the undergoing studies at CEA on detectors for the future submillimeter space missions.

Revéret, V.; Talvard, M.; André, P.; Rodriguez, L.; Le-Pennec, Y.; De Breuck, C.; Agnèse, P.; Boulade, O.; Delisle, C.; Doumayrou, E.; Dubreuil, D.; Ercolani, E.; Gallais, P.; Horeau, B.; Lagage, P.-O.; Leriche, B.; Lortholary, M.; Martignac, J.; Minier, V.; Pantin, E.; Rabanus, D.; Relland, J.; Visticot, F.; Willmann, G.

25

CEA monitoring of palliative treatment for colorectal carcinoma.  

PubMed Central

Palliative treatment was applied to 131 cases of unresectable or palliatively resected colorectal carcinoma being monitored with serial CEA determinations. There were 84 instances of disease progression with 67 (80%) of them showing an increase in CEA above pretreatment levels or maintaining high levels, and 17 (20%) showing a fall when compared to pretreatment values or maintaining low initial values. There was a clear-cut regression of the disease in only 9 instances. In all 9, the CEA clearly dropped or maintained low valles throughout the period of regression. No patient in regression had a rise or maintained an elevated CEA level. These changes in CEA followed closely the clinical response of our patient to the use of a particular agent, although for the Nitrosourea compounds there may be a tendency to lower the CEA regardless of the patient's tumor response to the drug. This could be due to the fact that the Nitrosoureas produce a diffuse block of cellular activity, both at the nucleous and cytoplasm; while other compounds act as alkylating agents or by inhibition of enzymes involved in the metabolism of nucleic acids (i.e., 5-FU inhibiting thymidylate synthetase). In general, longer survival was found in those patients who had initially lower levels of CEA as compared to those with high initial levels. The patients with a favorable CEA response to the treatment (falling CEA or maintained low value), even in many who did not show a clinical response had a longer survival than the group with rising or stable high levels. The main value in CEA monitoring of patients resides in its correlation with the amount of disease present and then its ability to detect progression of tumor mass which is not clinically measurable.

Herrera, M A; Chu, T M; Holyoke, E D; Mittelman, A

1977-01-01

26

Update on ignition studies at CEA  

NASA Astrophysics Data System (ADS)

The objective of the ICF program at CEA is to burn cryogenic DT with the Megajoule laser (LMJ). The laser will be completed in the year 2010 and its 240 beams will deliver up to 1.8MJ in 20ns at 0.35?m. There is a strong collaboration of CEA with DOE laboratories about the experiments done with the Omega laser for a few years: we sum up our main results regarding radiation temperature and symmetry with 2 or 3 cones of beams. We obtained also the first results about hydrodynamic instability with side-on radiography. LMJ prototype, LIL is composed of 4 beams will be used for the first plasma experiments in 2005 (in 2003 we obtained, with one beam, 7.5kJ in 5ns at 0.35µm): we will present the predictions of these experiments designed to be representative of LMJ conditions. The goal is to validate the smoothing technique (longitudinal SSD due to the focusing by grating) and to characterize the hohlraum, particularly with long pulses. The LMJ nominal capsule has a doped plastic ablator and is radiatively driven with a peak temperature of 300 eV. As far as the target design is concerned, the recent studies were devoted to 2 subjects: - the effect of anti-convection membranes in the hohlraum. The membranes are necessary for the cryogenic DT uniformity. - the assessment of random 3D laser imbalance and mispointing on the DT final deformation and it is compared to 2D ones.

Holstein, Pierre

2004-11-01

27

Tendances du produit interieur brut et du travail autonome dans les entreprises non constituees en societe de l'economie canadienne, 1987 a 2005  

Microsoft Academic Search

Le present document examine l'evolution du secteur des entreprises non constituees en societe a partir du nombre de travailleurs autonomes et du produit interieur brut (PIB) du secteur au cours de la periode de 1987 a 2005. En 2005, on comptait plus de 1,5 million de travailleurs autonomes dans des entreprises non constituees en societe, contribuant pour 93,2 milliards de

Luke Rispoli

2009-01-01

28

Evolution du système de pilotage de la performance et Système d'information : le cas de l'introduction de l'ABC à l'hôpital  

Microsoft Academic Search

L'introduction d'un nouveau mode de pilotage de la performance à l'hôpital interroge le système d'information hospitalier (SIH). Cette relation est analysée à partir du cas de l'introduction de l'ABC à l'hôpital. Une première étape consiste à étudier à partir de la littérature, d'une part, la pertinence de l'ABC dans le contexte de l'hôpital et d'autre part les constats des différents

Thierry Nobre; Lionel Signolet

2006-01-01

29

Volvulus du sigmoide necros? du postpartum  

PubMed Central

Le volvulus du sigmoïde compliquant la grossesse est une complication rare avec moins de 80 cas rapportés dans la littérature. Nous rapportons un cas de volvulus du sigmoïde compliquant les suites de couches. Une primigeste de 29-ans s'est présenté avec une douleur abdominale à J3 du post-partum. Une laparotomie exploratrice a révélé un volvulus, nécrosé, du côlon sigmoïde très distendu. Dans notre cas. Le Volvulus du sigmoïde est susceptible d'avoir été précipité par le changement rapide de la taille de l'utérus après l'accouchement. La mobilité colique associée à une distorsion du côlon sigmoïde, doit être gardé à l'esprit chez les patients qui présentent des douleurs abdominales lors du post-partum. Cet article se propose à travers un cas clinique de revoir les données de la littérature et d'engager les principes généraux de prise en charge et de traitement.

Moussaid, Ihsane; Haddad, Wafaa; Salmi, Said; Elyoussoufi, Smail; Miguil, Mohamed; Serbouti, Sihame; Boufettal, Houssine; Samouh, Naima; Berrada, Saad

2012-01-01

30

Carcino Embryonic Antigens (CEA) and Non-Specific Cross-Reacting Antigens in Feces  

Microsoft Academic Search

Carcino embryonic antigens (CEA) or CEA-like antigens were explored in 61 perchloric extracts from stools or meconium. CEA was present in 8 out of 30 extracts in digestive cancers and in 6 out of the 31 other extracts studied. Two other constituents called NCA and NCA2 were frequently found. They were partially identical with CEA immunochemically. Owing to their frequency,

H. H. Hirsch-Marie; G. Chavanel; P. Burtin

1973-01-01

31

Specific cytolytic T-cell responses to human CEA from patients immunized with recombinant avipox-CEA vaccine.  

PubMed

Avipox viruses are replication-defective members of the poxvirus family. Avipox-derived vectors such as ALVAC (canarypox) and fowlpox have the ability to infect mammalian cells, including human cells, but do not replicate. The first clinical trial of an avipox recombinant vaccine for patients with advanced carcinomas has recently been conducted using the ALVAC vector and the human carcinoembryonic antigen (CEA) transgene (designated ALVAC-CEA; J. L. Marshall et al, J. Clin. Oncol., 17: 332-337, 1999). The T-cell responses elicited by patients before and after vaccination with the ALVAC-CEA recombinants are characterized in this report. Pre- and postvaccination peripheral blood mononuclear cells (PMBCs) of the eight patients positive for HLA-class I A2 allele, were incubated with the HLA-A2-CEA peptide CAP-1 and interleukin 2. In no cases using prevaccination PMBCs could cultures be established that had the ability to lyse C1R-A2 target cells pulsed with the CAP-1 peptide. However, T-cell cultures from seven of eight of these same patients, obtained from PBMCs after ALVAC-CEA vaccination, were shown to lyse C1R-A2 cells only when pulsed with CAP-1. Moreover, all seven of these T-cell cultures were shown to lyse allogeneic human carcinoma cell lines (SW1463 and SW480) that were both A2+ and expressed CEA; an allogeneic tumor cell line (LS174T) expressing CEA that was negative for A2 expression was not lysed. HLA-A2+ and CEA+ autologous tumor cells were also capable of being lysed by CEA-specific T cells from this patient. Analysis of this CTL line also revealed the expression of several homing and adhesion-associated molecules. Fluorescence-activated cell sorter analysis of the T-cell lines established from patients after ALVAC-CEA vaccination revealed that most were CD8+/CD4-, but many also had a CD8+/CD4+ component. Analyses of T-cell receptor Vbeta usage of several of the CEA-specific CTL lines showed a relatively diverse Vbeta pattern. These studies demonstrate for the first time the ability to vaccinate cancer patients with an avipox recombinant and derive T cells that are capable of lysing allogeneic and autologous tumor cells in a MHC-restricted manner. These studies thus form the rationale to use such replication-deficient recombinant vaccines in future cancer vaccine trials. PMID:10656428

Zhu, M Z; Marshall, J; Cole, D; Schlom, J; Tsang, K Y

2000-01-01

32

Cri du chat syndrome  

MedlinePLUS

Cri du chat syndrome is a group of symptoms that result from missing a piece of chromosome number 5. The ... Cri du chat syndrome is rare. It is caused by a problem with chromosome 5. Most cases are believed to ...

33

Evolution a Long Terme des Emplois d'Ingenieur en France. Conclusions Principales d'une Etude Prospective Conduite par le CEFI sous la Direction du CNGE.  

ERIC Educational Resources Information Center

Described is a study that determined the long-term evolution of engineers' needs. Four essential tendencies which can be considered basic postulates for consideration and action are included. Recommendations based on the four postulates are presented. (KR)

Maury, Claude

1990-01-01

34

CEA bolometer arrays: the first year in space  

NASA Astrophysics Data System (ADS)

The CEA/LETI and CEA/SAp started the development of far-infrared filled bolometer arrays for space applications over a decade ago. The unique design of these detectors makes possible the assembling of large focal planes comprising thousands of bolometers running at 300 mK with very low power dissipation. Ten arrays of 16x16 pixels were thoroughly tested on the ground, and integrated in the Herschel/PACS instrument before launch in May 2009. These detectors have been successfully commissioned and are now operating in their nominal environment at the second Lagrangian point of the Earth-Sun system. In this paper we briefly explain the functioning of CEA bolometer arrays, and we present the properties of the detectors focusing on their noise characteristics, the effect of cosmic rays on the signal, the repeatability of the measurements, and the stability of the system.

Billot, Nicolas; Sauvage, M.; Rodriguez, L.; Horeau, B.; Kiss, C.; Aussel, H.; Okumura, K.; Boulade, O.; Altieri, B.; Poglitsch, A.; Agnèse, P.

2010-07-01

35

Sol-gel laser coatings at CEA Limeil-Valenton  

NASA Astrophysics Data System (ADS)

CEA Limeil-Valenton has embarked in a project called 'laser megajoule' (LMJ) consisting of the construction of a 2-MJ/500- TW (351-nm) pulsed Nd:glass laser and devoted to inertial confinement fusion research in France. Room temperature and atmospheric pressure deposited sol-gel coatings for antireflective (AR), highly reflective (HR) and polarizer uses, and silicone films for environmental protection have displayed remarkable optical and laser strength performance. Such coatings can be applied onto large area and at a low cost compared to conventional vacuum deposition techniques. CEA Limeil-Valenton is also maintaining sustained efforts to promote the sol-gel technology in other areas.

Floch, Herve G.; Belleville, Philippe F.

1997-10-01

36

The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues.  

PubMed

The human CEA family has been fully characterized. It comprises 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker for colorectal and some other carcinomas. The CEA subgroup members are cell membrane associated and show a complex expression pattern in normal and cancerous tissues with notably CEA showing a selective epithelial expression. Several CEA subgroup members possess cell adhesion properties and the primordial member, biliary glycoprotein, seems to function in signal transduction or regulation of signal transduction possibly in association with other CEA sub-family members. A modified ITAM/ITIM motif is identified in the cytoplasmatic domain of BGP. A role of CEA in innate immunity is envisioned. PMID:10202129

Hammarström, S

1999-04-01

37

Multiple myeloma presenting as CEA-producing rectal cancer  

PubMed Central

We report the case of a 57-year-old patient with multiple myeloma, characterized by extramedullary involvement of the rectum at presentation. Malignant plasma cells were found to produce carcinoembryonic antigen (CEA), a tumor antigen more commonly associated with rectal adenocarcinomas.

Talamo, Giampaolo; Barochia, Amitkumar; Zangari, Maurizio; Loughran, Thomas P

2010-01-01

38

Work on gamma Thermometer in C.E.A.  

National Technical Information Service (NTIS)

This report explains, the work made in CEA during the last years in the gamma thermometer field. In order to dispose of incore instrumentation able to measure the local reactor power, the use of gamma thermometer which measures the gamma energy absorbed i...

A. Bonnemay C. Cladel G. Ermumcu A. Le Dieu De Ville O. Hoclet

1979-01-01

39

EditEr: a combination of IEA and CEA  

Microsoft Academic Search

This paper studies the evolutionary learning of neural networks that can be decomposed into many homogeneous modules, and proposes a new algorithm by combining the individual evolutionary algorithm (IEA) and the co-evolutionary algorithm (CEA). The proposed algorithm has two parts. The first part, a modified version of the IEA, consists of four basic operations: evaluation, deletion, insertion and training. This

Qiangfu Zhao

1997-01-01

40

Serum CEA levels facilitate detection of recurrences of cancer in patients after gastrectomy  

Microsoft Academic Search

In an attempt to assess the usefulness of carcinoembryonic antigen (CEA) for predicting the progression of gastric cancer,\\u000a CEA productivity was evaluated according to serum CEA levels, at the time of recurrence or relapse. In cases of a recurrence,\\u000a abnormal CEA levels were observed in 14 of 17 (82.4 per cent) with differentiated carcinoma and in 9 of 21 (42.9

Ruuichiro Tamada; Yoichiro Hiramoto; Shunichi Tsujitani; Takashi Nozuka; Takeshi Okamura; Hidetaka Masuda; Keizo Sugimachi; Kiyoshi Inokuchi

1985-01-01

41

Stellenwert des CEA-Testes bei Malignomen im ORL-Bereich  

Microsoft Academic Search

Serum carcinoembryonic antigen (CEA) levels were determined in 80 patients, 65 with malignant and 15 with non-malignant affections. Among the malignant tumor bearing patients, in only 30% increased CEA levels were found. On the other hand, in the non-malignant patient group 33% had elevated CEA levels. It is concluded, that the determination of the CEA-Serum levels in malignomas of the

R. Grossenbacher

1979-01-01

42

Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive\\/ever hookah smokers  

Microsoft Academic Search

BACKGROUND: We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.). OBJECTIVES: To find serum CEA levels in ever\\/exclusive

Khan Mohammad Sajid; Kamal Chaouachi; Rubaida Mahmood

2008-01-01

43

Specific CEA-producing colorectal carcinoma cell killing with recombinant adenoviral vector containing cytosine deaminase gene  

Microsoft Academic Search

AIM: To kill CEA positive colorectal carcinoma cells specifically using the E coli cytosine deaminase (CD) suicide gene, a new replication-deficient recombinant adenoviral vector was constructed in which CD gene was controlled under CEA promoter and its in vitro cytotoxic effects were evaluated. METHODS: Shuttle plasmid containing CD gene and regulatory sequence of the CEA gene was constructed and recombined

Li-Zong Shen; Wen-Xi Wu; De-Hua Xu; Zhong-Cheng Zheng; Xin-Yuan Liu; Qiang Ding; Yi-Bing Hua; Kun Yao

44

Evaluation of Chief Executive Officers in Canadian School Boards. CEA Information Note.  

ERIC Educational Resources Information Center

The Canadian Education Association (CEA) examined the procedures Canadian School Boards use to evaluate their chief executive officers. In March 1989, CEA sent a questionnaire to superintendents and directors of education of the school boards that subscribe to the CEA Information Service, as well as to others. Of the 123 questionnaires sent, 81…

Canadian Education Association, Toronto (Ontario).

45

Plasma Levels of CEA as a Prognostic Marker in Carcinoma of Urinary Bladder  

Microsoft Academic Search

Plasma carcinoembryonic antigen (CEA) levels were performed preoperatively by radioimmunoassay in 124 patients with histologically proved bladder carcinoma. The level of CEA was used to determine its prognostic value in patients with bladder cancer. The correlation of CEA levels with the stage of the disease, histology, and resectability was also studied. Values above 2.5 ng\\/ml were taken as abnormal. Active

Elias A. K. Alsabti; M. H. Saffo

1979-01-01

46

Diagnostic usefulness of plasma carcinoembryonic antigen (CEA) levels in Crohn's disease  

Microsoft Academic Search

could be found (r = 0.026; P = NS). The relation between CEA levels and patients with remission or relapse did not show any significance and neither did the changing levels follow a typical pattern. Similarly plasma CEA was a poor predictor of the outcome of treatment. The occurrence of elevated CEA levels was unrelated to age of the patients

S. Meryn; H. Lochs

1983-01-01

47

Green fluorescent-conjugated anti-CEA single chain antibody for the detection of CEA-positive cancer cells.  

PubMed

According to World Health Organization (WHO), cancer is a leading cause of death worldwide, accounting for 7.4 million deaths (around 13% of all deaths) in 2004. Monoclonal/recombinant antibodies, which specifically target clinical biomarkers of disease, have increasingly been applied as powerful tools in cancer imaging and therapy, a fact that is highlighted by some nine FDA-approved monoclonal antibodies (MAbs) or their immunoconjugates (as of December 2008) for use in cancer treatment. In this study, five monoclonal antibodies (MAbs) were generated and characterized against carcinoembryonic antigen (CEA), which is widely used clinically as both a blood and tissue tumor marker of epithelial malignancy. Variable domains (VH and VL) of one the stable MAbs with highest affinity were PCR-amplified and assembled as single-chain antibody fragment (scFv). Following the cloning and expression of scFv antibody fragments in Escherichia coli, the functional binding and specificity of the recombinant antibody were confirmed by ELISA. To develop a direct in vitro detection of CEA-positive cancer cells, scFv DNA was genetically fused to enhanced green fluorescent protein (EGFP) gene and expressed in bacteria. The chimeric fluorescent protein is able to specifically detect CEA-positive cell lines; no cross-reactivity was observed with a negative control cell line. This strategy will likely allow the establishment of a rapid, single-step detection assay of CEA, which is considered to be one of the best predictors of malignancy among all other tumor markers. PMID:21707357

Salavatifar, Maryam; Amin, Shadi; Jahromi, Zahra Moghaddassi; Rasgoo, Nasrin; Rastgoo, Nasrin; Arbabi, Mehdi

2011-06-01

48

Further investigations of immunoreactive carcinoembryonic antigen (CEA) in colorectal cancer patients with particular emphasis on the correlation between immunoreactive CEA levels in tissue, feces and blood  

Microsoft Academic Search

Immunoreactive carcinoembryonic antigen (IR-CEA) levels in colorectal cancer and mucosal tissues, feces and blood were measured\\u000a in 14 colorectal cancer patients to study the correlation. IR-CEA levels in colorectal cancer tissues were about 30 times\\u000a higher than those in colonic mucosal tissues. The correlation coefficient between IR-CEA levels in the tumor tissue and serum\\u000a was 0.654 (p<0.02). We assumed that

Shigeru Fujimoto; Yukio Kitsukawa

1981-01-01

49

The CEA\\/CD3-Bispecific Antibody MEDI565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA  

Microsoft Academic Search

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced

Li Peng; Michael D. Oberst; Jiaqi Huang; Philip Brohawn; Chris Morehouse; Kristen Lekstrom; Patrick A. Baeuerle; Herren Wu; Yihong Yao; Steven R. Coats; William Dall’Acqua; Melissa Damschroder; Scott A. Hammond

2012-01-01

50

Le bassin sédimentaire a phosphates du Togo (Maastrichtien-Eocène): stratigraphie, environnements et évolutionThe phosphate sedimentary basin of Togo [Maastrichtian-Eocène): stratigraphy, environments and evolution)  

NASA Astrophysics Data System (ADS)

Studies carried out in the quarries at Tabligbo (klinker feed materials) Hahotoé and Kpogamé (phosphate extraction), coupled with core sample analyses of five boreholes, have led to a more precise stratigraphy of the Togo coastal basin and a younger age for the Tabligbo Limestones (Upper Palaeocene) and the palygorskite fissile-laminated Clays (Early Eocene). An outline of the depositional environment of the phosphate deposits is proposed through the sedimentary and dynamic evolution of the basin: transgression on to the continental margin, followed by a progressive deepening of the basin with deposition and preservation of organic matter; phosphates at the start of the regression; differential displacements of faulted blocks make a structural trap for the phosphates; accumulation and alteration of the phospharenite.

Johnson, Ampah Kodjo; Rat, Pierre; Lang, Jacques

2000-01-01

51

A Comprehensive Phylogenetic and Structural Analysis of the Carcinoembryonic Antigen (CEA) Gene Family  

PubMed Central

The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin (Ig) superfamily and codes for a vast number of glycoproteins that differ greatly both in amino acid composition and function. The CEA family is divided into two groups, the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) and the pregnancy-specific glycoproteins. The CEA family members are implicated in pleiotropic (patho)physiological functions including cell–cell adhesion, pregnancy, immunity, neovascularization, regulation of insulin homeostasis, and carcinogenesis. In general, the CEA-encoded proteins are composed of an extracellular region with Ig variable and constant-like domains and a cytoplasmic region containing signaling motifs. Of particular interest, the well-studied human and mouse CEA genes are arranged in clusters in a single chromosome. Taking into account this characteristic, we made an effort to reconstruct the evolutionary history of the CEA gene family. Toward this end, the publicly available genomes were searched extensively for CEA homologs. The domain organization of the retrieved protein sequences was analyzed, and, subsequently, comprehensive phylogenetic analyses of the entire length CEA homologous proteins were performed. A series of evolutionarily conserved amino acid residues, functionally important, were identified. The relative positioning of these residues on the modeled tertiary structure of novel CEA protein domains revealed that they are, also, spatially conserved. Furthermore, the chromosomal arrangement of CEA genes was examined, and it was found that the CEA genes are preserved in terms of position, transcriptional orientation, and number in all species under investigation.

Pavlopoulou, Athanasia; Scorilas, Andreas

2014-01-01

52

A Comprehensive Phylogenetic and Structural Analysis of the Carcinoembryonic Antigen (CEA) Gene Family.  

PubMed

The carcinoembryonic antigen (CEA) gene family belongs to the immunoglobulin (Ig) superfamily and codes for a vast number of glycoproteins that differ greatly both in amino acid composition and function. The CEA family is divided into two groups, the carcinoembryonic antigen-related cell adhesion molecules (CEACAMs) and the pregnancy-specific glycoproteins. The CEA family members are implicated in pleiotropic (patho)physiological functions including cell-cell adhesion, pregnancy, immunity, neovascularization, regulation of insulin homeostasis, and carcinogenesis. In general, the CEA-encoded proteins are composed of an extracellular region with Ig variable and constant-like domains and a cytoplasmic region containing signaling motifs. Of particular interest, the well-studied human and mouse CEA genes are arranged in clusters in a single chromosome. Taking into account this characteristic, we made an effort to reconstruct the evolutionary history of the CEA gene family. Toward this end, the publicly available genomes were searched extensively for CEA homologs. The domain organization of the retrieved protein sequences was analyzed, and, subsequently, comprehensive phylogenetic analyses of the entire length CEA homologous proteins were performed. A series of evolutionarily conserved amino acid residues, functionally important, were identified. The relative positioning of these residues on the modeled tertiary structure of novel CEA protein domains revealed that they are, also, spatially conserved. Furthermore, the chromosomal arrangement of CEA genes was examined, and it was found that the CEA genes are preserved in terms of position, transcriptional orientation, and number in all species under investigation. PMID:24858421

Pavlopoulou, Athanasia; Scorilas, Andreas

2014-01-01

53

"Tust du malen"?  

ERIC Educational Resources Information Center

Shows that using the German "tust du malen?" to teach the English construction "do you (paint, etc.)?" is wrong; the construction can also mean "are you painting?" So "tust du --?" fits only those English verbs which never use progressive tense forms. (Text is in German.) (IFS/WGA)

Siegrist, Ottmar K.

1976-01-01

54

CEA developments of new ferritic ODS alloys for nuclear applications  

NASA Astrophysics Data System (ADS)

During the last fifteen years, CEA has acquired much experience in the control of the microstructure and the mechanical properties of ODS alloys for nuclear applications. Each major step of the production process has been studied to get the best compromise for the fabrication route of ODS materials. From this scientific background, two new Fe-13/18CrWTi ferritic ODS alloys have been designed to meet the needs of the fusion or GEN-IV programs. These new materials have been investigated at a semi- industrial scale with different industrial partners and consolidated as small plates. The aim of this paper is to present the recent CEA developments on ODS materials, and to show the first results obtained on the Fe-18Cr1WTi new ferritic ODS alloy. The fabrication route for these new materials is presented, along with the measured mechanical properties and the preliminary microstructure characterizations. These new materials look promising for nuclear applications and are considered by CEA as reference materials for the development of new ODS alloys.

de Carlan, Y.; Bechade, J.-L.; Dubuisson, P.; Seran, J.-L.; Billot, P.; Bougault, A.; Cozzika, T.; Doriot, S.; Hamon, D.; Henry, J.; Ratti, M.; Lochet, N.; Nunes, D.; Olier, P.; Leblond, T.; Mathon, M. H.

2009-04-01

55

The AstroGrid Common Execution Architecture (CEA)  

NASA Astrophysics Data System (ADS)

The UK Virtual Observatory (VO) project AstroGrid (see http://www.astrogrid.org and related talks at this meeting) began in 2001 and is nearing the successful completion of its first release in December 2004. This paper describes AstroGrid's Common Execution Architecture (CEA). This is an attempt to create a reasonably small set of interfaces and schema to model how to execute a typical astronomical application within the VO. The CEA has been designed primarily to work within a web services framework, with the parameter passing mechanism layered on top of this so that the web interface for all applications is described by a single constant piece of WSDL - the differences between applications are expressed by the registry entries for each application. Within AstroGrid we have created pluggable components that can wrap legacy command-line applications, HTTP GET/POST applications and databases as CEA compliant web services, which when combined with the Astrogrid Workflow component make distributed processing within the VO a reality. See http://www.astrogrid.org/maven/docs/snapshot/applications/ for current information.

Harrison, P.; Winstanley, N.; Taylor, J. D.

2005-12-01

56

Radioimmunoscintigraphy of non-small cell lung cancer using Tc-99m ANTI-CEA FAB` (immuRAID CEA)  

SciTech Connect

We conducted a Phase II prospective multicenter clinical trial to investigate the safety and efficacy of Tc-99M anti-CEA Fab`(ImmuRAID-CEA) in patients with non-small cell lung cancer. Fifty four patients (42 male; 12 female; age range 40-93 yr) had primary operable (19), primary inoperable (7), occult (9), metastatic (15) or recurrent (4) disease. Patients were injected with 1 mg ImmuRAID-CEA radiolabeled with 20-30 mCi Tc-99m pertechnetate and imaged at 4-8 and 18-24 hr by planar and SPECT techniques; ten were imaged at 15-18 hr only. Despite prominent blood pool activity at 4-8 hr. overall imaging statistics on a per patient basis revealed a sensitivity of tumor detection of 90%, accuracy 85% and positive predictive value 94%. The later images had lower count rates but target to background ratios were improved. On a per lesion basis, sensitivity in the chest was 69% and in liver 88%. Twenty four patients had additional foci of antibody uptake at sites previously believed to be uninvolved; cancer was confirmed in 11, not confirmed in 2 and currently indeterminate in 11. Furthermore, a negative scan confirmed equivocal radiographic studies as true negative in 5 patients. With respect to safety, there were no adverse clinical reactions and four minor, transient changes in hematologic and/or biochemical parameters. Human anti-mouse antibody (HAMA) determinations on 27 patients using ImmuSTRIP{reg_sign} HAMA Fragment assay were negative at 4-6 weeks or 3 months post-infusion. We conclude that imaging with ImmuRAID-CEA is safe and potentially useful for the evaluation and staging of lung cancer patients.

Fig, L.M. [DVA Medical Center, Ann Arbor, MI (United States); Hughes, L.; Pinsky, C.M. [Immunomedics Inc., Morris Plains, NJ (United States)] [and others

1994-05-01

57

Sur la détermination du flux énergétique du rayonnement extraterrestre du Soleil  

Microsoft Academic Search

Le problème de la densité spectrale du flux énergétique du rayonnement solaire extraterrestre a été réexaminé en relation, avec le problème de la constante solaire. En utilisant les densités spectrales de flux énergétique du rayonnement global de la photosphère, on a déterminé la distribution spectrale extraterrestre du rayonnement solaire de 0,2 ? à 10 ?. Ces nouvelles données doivent être

M. Nicolet

1951-01-01

58

The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA  

PubMed Central

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms of CEA may affect MEDI-565 activity, we mapped the epitope of MEDI-565 on CEA using mutagenesis and homology modeling approaches. We found that MEDI-565 recognized a conformational epitope in the A2 domain comprised of amino acids 326–349 and 388–410, with critical residues F326, T328, N333, V388, G389, P390, E392, I408, and N410. Two non-synonymous single-nucleotide polymorphisms (SNPs) (rs10407503, rs7249230) were identified in the epitope region, but they are found at low homozygosity rates. Searching the National Center for Biotechnology Information GenBank® database, we further identified a single, previously uncharacterized mRNA splice variant of CEA that lacks a portion of the N-terminal domain, the A1 and B1 domains, and a large portion of the A2 domain. Real-time quantitative polymerase chain reaction analysis of multiple cancers showed widespread expression of full-length CEA in these tumors, with less frequent but concordant expression of the CEA splice variant. Because the epitope was largely absent from the CEA splice variant, MEDI-565 did not bind or mediate T-cell killing of cells solely expressing this form of CEA. In addition, the splice variant did not interfere with MEDI-565 binding or activity when co-expressed with full-length CEA. Thus MEDI-565 may broadly target CEA-positive tumors without regard for expression of the short splice variant of CEA. Together our data suggest that MEDI-565 activity will neither be impacted by SNPs nor by a splice variant of CEA.

Huang, Jiaqi; Brohawn, Philip; Morehouse, Chris; Lekstrom, Kristen; Baeuerle, Patrick A.; Wu, Herren; Yao, Yihong; Coats, Steven R.; Dall'Acqua, William; Damschroder, Melissa; Hammond, Scott A.

2012-01-01

59

The CEA/CD3-bispecific antibody MEDI-565 (MT111) binds a nonlinear epitope in the full-length but not a short splice variant of CEA.  

PubMed

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms of CEA may affect MEDI-565 activity, we mapped the epitope of MEDI-565 on CEA using mutagenesis and homology modeling approaches. We found that MEDI-565 recognized a conformational epitope in the A2 domain comprised of amino acids 326-349 and 388-410, with critical residues F(326), T(328), N(333), V(388), G(389), P(390), E(392), I(408), and N(410). Two non-synonymous single-nucleotide polymorphisms (SNPs) (rs10407503, rs7249230) were identified in the epitope region, but they are found at low homozygosity rates. Searching the National Center for Biotechnology Information GenBank® database, we further identified a single, previously uncharacterized mRNA splice variant of CEA that lacks a portion of the N-terminal domain, the A1 and B1 domains, and a large portion of the A2 domain. Real-time quantitative polymerase chain reaction analysis of multiple cancers showed widespread expression of full-length CEA in these tumors, with less frequent but concordant expression of the CEA splice variant. Because the epitope was largely absent from the CEA splice variant, MEDI-565 did not bind or mediate T-cell killing of cells solely expressing this form of CEA. In addition, the splice variant did not interfere with MEDI-565 binding or activity when co-expressed with full-length CEA. Thus MEDI-565 may broadly target CEA-positive tumors without regard for expression of the short splice variant of CEA. Together our data suggest that MEDI-565 activity will neither be impacted by SNPs nor by a splice variant of CEA. PMID:22574157

Peng, Li; Oberst, Michael D; Huang, Jiaqi; Brohawn, Philip; Morehouse, Chris; Lekstrom, Kristen; Baeuerle, Patrick A; Wu, Herren; Yao, Yihong; Coats, Steven R; Dall'Acqua, William; Damschroder, Melissa; Hammond, Scott A

2012-01-01

60

Anti-CEA antibody fragments labeled with [(18)F]AlF for PET imaging of CEA-expressing tumors.  

PubMed

A facile and rapid method to label peptides with (18)F based on chelation of [(18)F]AlF has been developed recently. Since this method requires heating to 100 °C, it cannot be used to label heat-sensitive proteins. Here, we used a two-step procedure to prepare (18)F-labeled heat-labile proteins using the [(18)F]AlF method based on hot maleimide conjugation. 1,4,7-Triazacyclononae-1,4-diacetate (NODA) containing a methyl phenylacetic acid group (MPA) functionalized with N-(2-aminoethyl)maleimide (EM) was used as a ligand which was labeled with [(18)F]AlF and then conjugated to the humanized anti-CEA antibody derivatives hMN-14-Fab', hMN-14-(scFv)2 (diabody), and a Dock-and-Lock engineered dimeric fragment hMN-14 Fab-AD2 at room temperature. The in vivo tumor targeting characteristics of the (18)F-labeled antibody derivatives were determined by PET imaging of mice with s.c. xenografts. NODA-MPAEM was radiolabeled with [(18)F]AlF at a specific activity of 29-39 MBq/nmol and a labeling efficiency of 94 ± 2%. The labeling efficiencies of the maleimide conjugation ranged from 70% to 77%, resulting in [(18)F]AlF-labeled hMN14-Fab', hMN14-Fab-AD2, or hMN14-diabody with a specific activity of 15-17 MBq/nmol. The radiolabeled conjugates were purified by gel filtration. For biodistribution and microPET imaging, antibody fragments were injected intravenously into BALB/c nude mice with s.c. CEA-expressing LS174T xenografts (right flank) and CEA-negative SK-RC-52 xenografts (left flank). All [(18)F]AlF-labeled conjugates showed specific uptake in the LS174T xenografts with a maximal tumor uptake of 4.73% ID/g at 4 h after injection. Uptake in CEA-negative SK-RC-52 xenografts was significantly lower. Tumors were clearly visualized on microPET images. Using a [(18)F]AlF-labeled maleimide functionalized chelator, antibody fragments could be radiofluorinated within 4 h at high specific activity. Here, we translated this method to preclinical PET imaging studies and showed feasibility of [(18)F]AlF-fluorinated hMN-14-Fab', [(18)F]AlF-hMN-14-Fab-AD2, and [(18)F]AlF-hMN-14-diabody for microPET imaging of CEA-expressing colonic cancer. PMID:24382090

Lütje, S; Franssen, G M; Sharkey, R M; Laverman, P; Rossi, E A; Goldenberg, D M; Oyen, W J G; Boerman, O C; McBride, W J

2014-02-19

61

Serial carcinoembryonic antigen (CEA) blood levels in patients with ulcerative colitis  

Microsoft Academic Search

Fifty-seven patients with ulcerative colitis were followed 1–49 months (mean, 18 months) with serial CEA determinations during periods of remission, mild relapses, and severe relapses. Elevated CEA titers correlated with activity and possibly extent of disease: 12% of patients with proctitis, 47% of patients with left-sided colitis, and 60% of patients with transverse or universal colitis had elevated CEA titers

Richard C. Gardner; Arthur E. Feinerman; Paul A. Kantrowitz; Stephen Gootblatt; Matthew S. Loewenstein; Norman Zamcheck

1978-01-01

62

Progrès technique, emploi et exclusion du marché du travail  

Microsoft Academic Search

[fre] Progrès technique, emploi et exclusion du marché du travail. . Cet article étudie l'impact de la croissance sur l'emploi, le chômage et l'exclusion du marché du travail dans un cadre où les chômeurs subissent des pertes de capital humain relativement aux travailleurs employés, de telle sorte que, s'ils dépassent une certaine ancienneté dans le chômage, ils peuvent devenir inemployables.

Fabien Postel-Vinay; Pierre Granier

1999-01-01

63

Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer.  

PubMed

Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid) and surface-functionalized with anticarcinoembryonic antigen (anti-CEA) and successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC) cells. The as-developed nanosized material device, consisting of surface decorated maghemite nanoparticles suspended as a biocompatible magnetic fluid (MF) sample, labeled MF-anti-CEA, was characterized and tested against two cell lines: a high-CEA expressing cell line (LS174T) and a low-CEA expressing cell line (HCT116). Whereas X-ray diffraction was used to assess the average core size of the as-synthesized maghemite particles (average 8.3 nm in diameter), dynamic light scattering and electrophoretic mobility measurements were used to obtain the average hydrodynamic diameter (550 nm) and the zeta-potential (-38 mV) of the as-prepared and maghemite-based nanosized device, respectively. Additionally, surface-enhanced Raman spectroscopy (SERS) was used to track the surface decoration of the nanosized maghemite particles from the very first precoating up to the attachment of the anti-CEA moiety. The Raman peak at 1655 cm(-1), absent in the free anti-CEA spectrum, is the signature of the anti-CEA binding onto the precoated magnetic nanoparticles. Whereas MTT assay was used to confirm the low cell toxicity of the MF-anti-CEA device, ELISA and Prussian blue iron staining tests performed with both cell lines (LS174T and HCT116) confirm that the as-prepared MF-anti- CEA is highly specific for CEA-expressing cells. Finally, transmission electron microscopy analyses show that the association with anti-CEA seems to increase the number of LS174T cells with internalized maghemite nanoparticles, whereas no such increase seems to occur in the HCT116 cell line. In conclusion, the MF-anti-CEA sample is a biocompatible device that can specifically target CEA, suggesting its potential use as a theragnostic tool for CEA-expressing tumors, micrometastasis, and cancer-circulating cells. PMID:23055733

da Paz, Mariana Campos; Santos, Maria de Fátima M Almeida; Santos, Camila M B; da Silva, Sebastião W; de Souza, Lincoln Bernardo; Lima, Emília C D; Silva, Renata C; Lucci, Carolina M; Morais, Paulo César; Azevedo, Ricardo B; Lacava, Zulmira G M

2012-01-01

64

Comparison of multiple anti-CEA immunotoxins active against human adenocarcinoma cells.  

PubMed

Anti-carcinoembryonic antigen (CEA) immunotoxins constructed with multiple anti-CEA antibodies (goat and baboon polyclonal, and three murine monoclonal antibodies) by covalently linking them to the A chain of ricin via a disulfide bond all function as potent and specific toxins for CEA-bearing cells, suggesting that the CEA molecule is capable of directing productive internalization of ricin A chain. The high potency of anti-CEA immunotoxins apparently makes addition of ricin B chain unnecessary for high toxic efficiency, as in some other systems, because presence of the B chain reduces target cell specificity. Several characteristics of the immunotoxins which might account for their cytotoxic potency were studied. Equilibrium association constants of the goat, baboon, and murine monoclonal C-19 antibodies with fluid-phase CEA were determined by using Langmuir plots and were found to be 8.79, 6.61, and 8.13 X 10(9) M-1, respectively, indicating the high and similar affinities of the three antibodies toward CEA. Radioimmunoassay binding studies of the three immunotoxins with 125I-CEA showed that the antibody portions of the molecules retained the ability to form complexes with CEA after conjugation to ricin A chain. The maximum number of anti-CEA antibody molecules bound per cell, as demonstrated by 111In-labeled C-19 binding assays with CEA-bearing cell lines, varied from 2.65 X 10(5) per cell for HT29 to 2.01 X 10(6) for LoVo, with an intermediate value of 1.17 X 10(6) per cell for WiDr. Cytotoxicity of the immunotoxins was assessed by inhibition of protein synthesis and expressed as a median inhibitory dose (ID50). Comparison of the ID50's of each immunotoxin on the three cell lines has shown that the immunotoxin made of the monoclonal C-19 antibody is in general 6 to 7 times more cytotoxic than the goat and baboon antibody immunotoxins. The affinity of CEA-antibody binding is probably an important, but not a sole factor in determining the immunotoxin potency. The fact that the antibodies with very similar affinity toward fluid phase CEA make immunotoxins of different potency might indicate that interactions with membrane-bound CEA are more complex and/or the efficiency of internalization of various immunotoxins is different. An important factor in immunotoxin action appears to be the CEA content in target adenocarcinoma cells. PMID:3496151

Levin, L V; Griffin, T W; Childs, L R; Davis, S; Haagensen, D E

1987-01-01

65

Anti-CEA loaded maghemite nanoparticles as a theragnostic device for colorectal cancer  

PubMed Central

Nanosized maghemite particles were synthesized, precoated (with dimercaptosuccinic acid) and surface-functionalized with anticarcinoembryonic antigen (anti-CEA) and successfully used to target cell lines expressing the CEA, characteristic of colorectal cancer (CRC) cells. The as-developed nanosized material device, consisting of surface decorated maghemite nanoparticles suspended as a biocompatible magnetic fluid (MF) sample, labeled MF-anti-CEA, was characterized and tested against two cell lines: a high-CEA expressing cell line (LS174T) and a low-CEA expressing cell line (HCT116). Whereas X-ray diffraction was used to assess the average core size of the as-synthesized maghemite particles (average 8.3 nm in diameter), dynamic light scattering and electrophoretic mobility measurements were used to obtain the average hydrodynamic diameter (550 nm) and the zeta-potential (?38 mV) of the as-prepared and maghemite-based nanosized device, respectively. Additionally, surface-enhanced Raman spectroscopy (SERS) was used to track the surface decoration of the nanosized maghemite particles from the very first precoating up to the attachment of the anti-CEA moiety. The Raman peak at 1655 cm?1, absent in the free anti-CEA spectrum, is the signature of the anti-CEA binding onto the precoated magnetic nanoparticles. Whereas MTT assay was used to confirm the low cell toxicity of the MF-anti-CEA device, ELISA and Prussian blue iron staining tests performed with both cell lines (LS174T and HCT116) confirm that the as-prepared MF-anti- CEA is highly specific for CEA-expressing cells. Finally, transmission electron microscopy analyses show that the association with anti-CEA seems to increase the number of LS174T cells with internalized maghemite nanoparticles, whereas no such increase seems to occur in the HCT116 cell line. In conclusion, the MF-anti-CEA sample is a biocompatible device that can specifically target CEA, suggesting its potential use as a theragnostic tool for CEA-expressing tumors, micrometastasis, and cancer-circulating cells.

da Paz, Mariana Campos; de Fatima M Almeida Santos, Maria; Santos, Camila MB; da Silva, Sebastiao W; de Souza, Lincoln Bernardo; Lima, Emilia CD; Silva, Renata C; Lucci, Carolina M; Morais, Paulo Cesar; Azevedo, Ricardo B; Lacava, Zulmira GM

2012-01-01

66

Les paradoxes du changement organisationnel  

Microsoft Academic Search

Le thème du changement organisationnel renvoie à la problématique du volontarisme et des capacités d'action sur et dans les systèmes organisés. En fonction des différentes positions adoptées par rapport aux débats volontarisme \\/ déterminisme ; action \\/ structure ; changement \\/ stabilité, les analyses du changement ainsi que les préconisations quant à sa mise en œuvre varieront. Cependant si sur

Véronique Perret

2003-01-01

67

A novel mouse model for evaluation and prediction of HLA-A2-restricted CEA cancer vaccine responses.  

PubMed

Human leukocyte antigen (HLA)-A2.1 transgenic mice (HHD) represent a valuable model to study and predict the immunogenicity of vaccines against pathogens. However, HHD mice are unsuitable for in vivo studies of cancer vaccines against human tumor-associated antigens because they lack T-cell tolerance that is key to define the potency of the treatment. In this study, we developed HHD/carcinoembryonic antigen P(CEA) hybrid mice by breeding transgenic mice homozygous for CEA with HHD. These mice express human CEA, present epitopes solely through HLA-A2.1 molecules and constitute a unique in vivo animal model to study HLA-A2.1-restricted immune response of a human CEA-based vaccine. Owing to the immune tolerance, HHD/CEA mice show a limited immune response and expansion of a different and restricted T-cell receptor repertoire after antigen-specific stimulation. Our data show that genetic vectors expressing CEA and peptide-based vaccines are able to efficiently break immune tolerance against CEA and to elicit strong immune response against HLA-A2.1-restricted CEA epitopes. Most importantly, efficient lysis of human CEA+/HLA-A2.1+ tumor cells was observed and significant protection against HHD/CEA tumor cells was achieved in HHD/CEA-vaccinated mice. Hence, HHD/CEA provides a relevant model for the evaluation of the potential efficacy of human CEA-based vaccines. PMID:19561534

Conforti, Antonella; Peruzzi, Daniela; Giannetti, Patrizia; Biondo, Antonella; Ciliberto, Gennaro; La Monica, Nicola; Aurisicchio, Luigi

2009-09-01

68

DNA Vaccines Encoding CEA and a CD40 Ligand and Methods of use Thereof.  

National Technical Information Service (NTIS)

A DNA vaccine effective for eliciting an immune response against cells that present a carcinoembryonic antigen (CEA) comprises a DNA operably encoding a CEA and a DNA operably encoding a CD40 ligand, SEQ ID NO:1 and SEQ ID NO: 2, respectively, or its homo...

R. Xiang R. A. Reisfeld

2005-01-01

69

A prospective evaluation of serum carcinoembryonic antigen (CEA) levels in the management of colorectal carcinoma  

Microsoft Academic Search

The relationship between the pattern of carcinoembryonic antigen (CEA) changes and the types of recurrence was investigated in a prospective study of 146 patients who underwent curative operations for adenocarcinoma of the colon or rectum. Recurrences developed in 51 patients (34.9%) and was local in 14, distant in 23, and both local and distant in 14 of them. CEA slope

John Boey; H. C. Cheung; C. K. Lai; John Wong

1984-01-01

70

Performances Of Herschel/PACS Bolometer Arrays And Future Developments At CEA  

NASA Astrophysics Data System (ADS)

The PACS Photometer of the Herschel Space Observatory is equipped with filled bolometer arrays developed by CEA/LETI and CEA/SAp. These innovative detectors allow to dispense with bulky light concentrators and to instantaneously sample the field of view without altering the optical coupling of the detectors to the telescope beam. CEA/LETI opted for an all-silicon design to allow for the collective manufacturing of 16x16 bolometer arrays. Being 3-side buttable these arrays are now the building blocks for making large focal planes necessary for the next generation of wide-field sub-mm cameras. We present the unique architecture of CEA filled bolometer arrays and we report on the latest performance measurements of the Herschel/PACS Photometer. We also present current and future developments at CEA for ground-based, balloon borne and space telescopes.

Ali, Babar; Billot, N.; Rodriguez, L.; Okumura, K.; Sauvage, M.; Agnese, P.

2009-01-01

71

Etude du comportement du niobium IV et du titane III dans quelques oxydes à structure en cages du type A 3M 8O 21 I. Synthèse et evolution structurale des solutions solides Ba 3Nb 4+ xTi 4- xO 21, K 3Nb 7+ xTi 1- xO 21, et K 3- xBa xNb 8O 21  

NASA Astrophysics Data System (ADS)

New solid solutions A3Nb 8- xTi xO 21 ( A = K, Ba) and K 3- xBa xNb 8O 21 have been synthesized. They crystallize in the hexagonal A3M 8O 21 structure. In the series Ba 3Nb 4+ xTi 4- xO 21 (0 ? x ? 4) and K 3Nb 7+ xTi 1- xO 21 (0 ? x ? 1) the break in the evolution of the lattice constants observed respectively for x = 2 for the former and x = 0.5 for the latter has been interpreted as the result of the reaction Nb IV + Ti IV ? Nb V + Ti III. The better stability for the combination Nb V/Ti III in the host lattice is confirmed by the estimation of the energy levels in the structure which takes into consideration the ionization and the polarization energies.

Chailleux, J. M.; Groult, D.; Mercey, C.; Studer, F.; Raveau, B.

1981-03-01

72

ECRIN and MultiCusp Sources at CEA Saclay  

NASA Astrophysics Data System (ADS)

A 2.45 GHz electron cyclotron resonance test stand based on a pure volume H- negative ion production is presently running at CEA Saclay. This negative ion source (ECRIN) is working in pulsed mode, up to 10 ms at 10 Hz. Several modifications allowed increasing the extracted H- current from the source. Those results will be summed up in the first part. With the experience collected from this source, a second one using a multi-cups magnetic structure is under development. Magnetic calculations and simulations showed that an octupolar configuration could allow improving the H- ion production. Those simulations will be discussed and the new set up will also be presented. The source is now being assembled on a new test bench, called BETSI, for light ion source development based on permanent magnet structure.

Tuske, O.; Charruau, G.; Delferrière, O.; de Menezes, D.; Gobin, R.; Gauthier, Y.; Harrault, F.; Madur, A.

2007-08-01

73

TRIPOLI-4®, CEA, EDF and AREVA Reference Monte Carlo Code  

NASA Astrophysics Data System (ADS)

This paper presents an overview of TRIPOLI-4®, the fourth generation of the 3D continuous-energy Monte Carlo code developed by the Service d'Etudes des Réacteurs et de Mathématiques Appliquées (SERMA) at CEA Saclay. The paper surveys the generic features: programming language, parallel operation, tracked particles, nuclear data, geometry, simulation modes, standard variance reduction techniques, sources, tracking and collision algorithms, tallies, sensitivity studies. Moreover, specific and recent features are also detailed: Doppler broadening of the elastic scattering kernel, neutron and photon material irradiation, advanced variance reduction techniques, Green's functions, cycle correlation correction, nuclear data management and depletion capabilities. The productivity tools (T4G, SALOME TRIPOLI, T4RootTools), the Verification & Validation process and the distribution and licensing policy are finally presented.

2014-06-01

74

Recent advances in indirect drive ICF physics at CEA  

NASA Astrophysics Data System (ADS)

The objective of Target Physics Program at CEA is the achievement of ignition on the LMJ, a glass laser facility of 1.8 MJ which will be competed by 2008. They include theoretical work, experimental work and numerical simulations. An important part of experimental studies is made in collaboration with US DOE Laboratories: Lawrence Livermore National Laboratory, Los Alamos National Laboratory and the Laboratory for Laser Energetics at the University of Rochester. Experiments were performed on Phebus, NOVA and OMEGA; they included diagnostics developments. Recent efforts have been focused on Laser Plasma Interactions, hohlraum energetics, symmetry, ablator physics and hydrodynamic instabilities. Ongoing work prepare the first experiments on the LIL which is a prototype facility of the LMJ. They will be performed by 2002. Recent progress in ICF target physics allows us to precise laser specifications to achieve ignition with reasonable margin.

Tassart, J.; Bonnaud, Guy; Bourgade, Jean-Luc; Casanova, M.; Dague, Nicolas; Dattolo, E.; Galmiche, D.; Giorla, Jean; Hallo, L.; Holstein, P. A.; Jacquemot, Sylvie; Jadaud, J. P.; Jolas, A.; Juraszek, D.; Laffite, S.; Lefebvre, Erik; Monteil, M. C.; Mourenas, D.; Nicolai, P.; de Prandieres, E.; Richard, Andre L.; Vandenboomgaerde, M.; Vanderhaegen, D.; Vilette, B.

2001-04-01

75

Performance verification of the MIRI imager flight model at CEA  

NASA Astrophysics Data System (ADS)

MIRIM is the imager of the Mid Infrared Instrument (MIRI), one of the three scientific instruments on the James Webb Space Telescope (JWST). MIRIM will provide imaging between 5.6?m and 25.5?m, low resolution spectroscopy (LRS) between 5 and 10?m, and coronagraphy at 10.65?m, 11.4?m, 15.5?m and 23?m. The Optical bench Assembly of MIRIM Flight Model (FM) has been integrated and tested between 2008 and 2009 at CEA (Saclay, France). The tests consist in characterisation of optical performances at all wavelengths and in all three modes (imaging, spectroscopy and coronagraphy), using a test bench (or Ground Support Equipment - GSE) that has been developed for this purpose. The GSE comprises a helium cooled cryostat for the instrument itself, a proto-IR focal plane module (with JPL sensor chip and CEA electronics and housing), a warm telescope simulator that delivers a JWST-like beam, and computers and software for running automatic test procedures. It is designed to allow a large set of performance verifications, such as high-resolution PSF measurements, characterisation of coronagraphs, response to monochromatic line or resolving power of the spectroscopic mode, some of them being unique along the test program of the instrument. After a short description of the test equipment, this paper focuses on the tests results. A full assessment of performances is given. When applicable, performances are cross checked with requirements. Imaging mode and coronagraphy had already been validated on optically representative models along the MIRIM development plan, especially with the Engineering and Test Model (ETM) of MIRIM, early 2008. The FM test campaign allowed us to confirm that the flight model behaves as expected in these two modes. We also tested for the first time, and validated, the low-resolution spectroscopy mode.

Ronayette, S.; Cavarroc, C.; Kendrew, S.; Amiaux, J.; Auguères, J.-L.; Bouzat, M.; Guillard, P.; Moreau, V.; Pantin, E.; Bouchet, P.; Bensalem, A.; Orduna, T.; Lagage, P.-O.; Nehme, C.; Belu, A.; Glasse, A.; Baudoz, P.; Dubreuil, D.

2010-07-01

76

Inhibition of endogenous carcinoembryonic antigen (CEA) increases the apoptotic rate of colon cancer cells and inhibits metastatic tumor growth  

Microsoft Academic Search

It has been suggested that carcinoembryonic antigen (CEA) enhances metastatic seeding of colon cancer cells due to its homo-\\u000a and heterophilic binding properties. Our recent finding that endogenous CEA protects colon cancer cells against apoptosis\\u000a suggests a more complex role of CEA in cancer progression. In this study we compared the in vitro effects of endogenous CEA on tumor cell

Thomas Wirth; Edlyn Soeth; Frank Czubayko; Hartmut Juhl

2002-01-01

77

Khan Du Chris.  

National Technical Information Service (NTIS)

The video features Chris, who is deaf, and others with the same disability, as role models talking about their careers. Khan du, and viewers without hearing impairments experience what deafness is and how deprivation of hearing can cause one to feel left ...

1994-01-01

78

An experimental immunoscintigraphic study with anti-CEA monoclonal antibody (DG2).  

PubMed

Monoclonal antibody D11-DG2 (DG2) against carcinoembryonic antigen (CEA) was examined for suitability for radioimmunodetection of human tumors grown in nude mice. Antibodies DG2 and a control antibody of the same IgG1 subclass were labeled with 131I and injected into mice bearing one of three types of CEA-containing tumors (cell lines LS 174T, HT-29 and Rec S) and/or a CEA-negative tumor (Rec R). Gamma-camera imaging and distribution studies revealed that CEA-containing tumors selectively accumulate DG2 but Rec R does not. As the tumors differ in CEA-content, the highest accumulation of 131I-DG2 (corresponding to the best scintigraphic imaging) was found in LS 174T tumors, intermediate in Rec S and lowest in HT-29 tumors. The mean tumor-to-blood ratios on the sixth day after antibody administration were 4.6, 3.2, and 2.1, respectively, in the control experiments the value of this parameter was always lower than 1. The results showed the applicability of DG2 for immunoscintigraphic studies in patients. Furthermore, a positive correlation was found between the uptake of anti-CEA antibody and CEA-content in the tumors. PMID:2320177

Koprivová, H; Novák, F; Poucková, P; Svihovcová, P; Jantscheff, P; Bötgger, V; Micheel, B; Dvorák, P; Seblová, J; Pospísil, J

1990-01-01

79

Drug-induced modulation of carcinoembryonic antigen (CEA) expression in neoplastic cells from a patient with rectal cancer.  

PubMed

Treatment with 5-fluorouracil (5-FU) or recombinant interferon-gamma (IFN), alone or in combination, was found to increase carcinoembryonic antigen (CEA) expression in several carcinoma cell lines. In this study we examined the in vitro effect of these agents on CEA expression of tumor cells, obtained from a patient operated for rectal cancer. The results showed that exposure of cancer cells to 5-FU or to IFN resulted in increased CEA levels in terms of percentage of CEA-positive cells and mean fluorescence values, as indicated by FACS analysis. However, drug combination did not induce CEA expression higher than that provided by single agents alone. Treatment with 5-FU or with IFN produced a reduction of the total number of viable cells. Moreover, Western blot analysis revealed that exposure of cancer cells to each drug was followed by a substantial increase of the total cellular CEA content. On the contrary, 5-FU in combination with IFN did not increase the expression of the antigen more than that obtained by single agents. Noteworthy, exposure of CEA-negative cells from adjacent normal rectal tissue to both agents alone or in combination, did not result in CEA induction. In conclusion, the present results suggest new approaches aimed at (a) increasing the sensitivity of diagnostic procedures based on detection of CEA-positive tumor cells; (b) facilitating the recognition of CEA-positive cancer cells by immune responses induced by anti-CEA peptide vaccines. PMID:11277324

Cappelletti, D; Cardillo, A; Bonanno, E; Prete, S P; Cucchiara, G; Turriziani, M; Greiner, J W; Cottarelli, A; Breda, E; Aquino, A; Bonmassar, E; De Vecchis, L

2000-12-01

80

Kyste hydatique primitif du sein  

PubMed Central

Le kyste hydatique du sein est une parasitose rare même dans les pays endémiques. Nous rapportons une nouvelle observation d'une patiente de 30 ans qui présentait une masse du sein gauche. Le diagnostic de kyste hydatique du sein a été évoqué devant les données de l'examen clinique et de la mammographie couplée à l’échographie. Le geste chirurgical a consisté en une kystectomie. L'examen anatomopathologique de la pièce opératoire a confirmé le diagnostic.

Mouslik, Rabii; Settaf, Abdellatif; Elalami, Yacir; Lahnini, Hicham; Lahlou, Khalid; Chad, Bouziane

2012-01-01

81

A Mini Linac Based Positron Source at CEA-Saclay  

NASA Astrophysics Data System (ADS)

We are installing at CEA-Saclay a demonstration setup for an intense positron source. It is based on a compact 5.5 MeV electron linac used to produce positrons via pair production on a tungsten target. A relatively high current of 0.15 mA compensates for low positron efficiencies at low energy, which is below the neutron activation threshold. The expected production rate is 5.1011 fast positrons per second. A set of coils is arranged to select the fast positrons from the diffracted electron beam in order to study the possibility of using a rare gas cryogenic moderator away from the main flux of particles. The commissioning of the linac is under way. This setup is part of a project to demonstrate the feasibility of an experiment to produce the H+ ions for a free fall measurement of neutral antihydrogen (H). Its small size and cost could be of interest for material science applications, after adaptation of the time structure.

Debu, P.; Liszkay, L.; Pérez, P.; Rey, J.-M.; Sacquin, Y.; Blideanu, V.; Curtoni, A.; Delferriere, O.; Dupré, P.; Muranaka, T.; Ruiz, N.

2009-09-01

82

Is tissue polypeptide antigen more accurate than serum CEA for diagnosing pancreatic cancer?  

PubMed Central

Tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) were determined in the sera of 36 control subjects, 30 patients with pancreatic cancer, 35 with chronic pancreatitis and 25 with non-pancreatic digestive disease to evaluate their role in detecting pancreatic malignancy. Abnormal values of TPA and CEA were found in 28 and 19 of 30 patients with pancreatic cancer, and in four and seven of 35 patients with chronic pancreatitis, respectively. Raised titres of TPA were observed more often than equivalent serum CEA in simulated pancreatic diseases. The receiver-operating (ROC) characteristic curves showed that TPA was more discriminating than CEA in detecting pancreatic cancer. Specificity was enhanced when both titres were abnormally high and sensitivity when one titre was raised, but the diagnostic accuracy of TPA alone has not improved, which satisfactorily discriminates pancreatic cancer from chronic pancreatitis.

Panucci, A; Fabris, C; Del Favero, G; Basso, D; Di Mario, F; Marchioro, L; Piccoli, A; Lise, M; Burlina, A; Naccarato, R

1986-01-01

83

Building Task-Based User Interfaces with ANSI\\/CEA2018  

Microsoft Academic Search

The recently approved ANSI\\/CEA-2018 standard is motivated by the current usability crisis in computer controlled electronic products. The standard facilitates a new user interface design methodology that uses a task model at runtime to guide users.

Charles Rich

2009-01-01

84

Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics  

NASA Technical Reports Server (NTRS)

In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

Milos, Frank S.

2011-01-01

85

Network and system diagrams revisited: Satisfying CEA requirements for causality analysis  

SciTech Connect

Published guidelines for Cumulative Effects Assessment (CEA) have called for the identification of cause-and-effect relationships, or causality, challenging researchers to identify methods that can possibly meet CEA's specific requirements. Together with an outline of these requirements from CEA key literature, the various definitions of cumulative effects point to the direction of a method for causality analysis that is visually-oriented and qualitative. This article consequently revisits network and system diagrams, resolves their reported shortcomings, and extends their capabilities with causal loop diagramming methodology. The application of the resulting composite causality analysis method to three Environmental Impact Assessment (EIA) case studies appears to satisfy the specific requirements of CEA regarding causality. Three 'moments' are envisaged for the use of the proposed method: during the scoping stage, during the assessment process, and during the stakeholder participation process.

Perdicoulis, Anastassios [University of Tras-os-Montes e Alto Douro, 5001-801 Vila Real (Portugal); University of Tras-os-Montes e Alto Douro, 5001-801 Vila Real (Portugal); Piper, Jake [Oxford Institute for Sustainable Development, Oxford Brookes University, Headington Campus, Gipsy, Lane, Oxford OX3 0BP (United Kingdom)

2008-10-15

86

Low and Medium Level and Transuranic Waste Characterization: CEA Objectives and Experience.  

National Technical Information Service (NTIS)

The CEA studies devoted to characterization are being extended to the long term behavior. Two characterization programs of conditioned wastes (embedded wastes in cement and embedded wastes in bitumen) are reported. (ERA citation 10:012412)

B. O. Bruyere

1984-01-01

87

The effect of tumor CEA content and tumor size on tissue uptake of indium 111-labeled anti-CEA monoclonal antibody.  

PubMed

This study was undertaken to determine the effect of tumor size and tumor carcinoembryonic antigen (CEA) content on the uptake of indium 111 (111In)-labeled anti-CEA monoclonal antibody in nude mice bearing xenografts. The tumor cell lines were WiDr, SW403, and LS174T, human colon cancer derivatives. The murine breast carcinoma cell line EMT-6 was used as a control. Tumor CEA levels (ng/g of tumor +/- standard error of the mean [SEM], measured by enzyme immunoassay (EIA) were: EMT-6, 0; WiDr, 105 +/- 5.7; LS174T, 2052 +/- 198; SW403, 17,575 +/- 1,785. The 111In-labeled monoclonal antibody was injected intravenously into mice bearing a single tumor. At 48 hours postinjection, scintiscan was performed, and the mice were killed so that biodistribution studies could be performed. The uptake of the monoclonal antibody was expressed as percent injected counts per minute per gram of tissue +/- SEM. The non-CEA-producing tumor, EMT-6, showed the lowest tumor uptake (1.4 +/- 0.3). WiDr, an intermediate CEA-producing tumor, showed some tumor uptake (16.4 +/- 1.5). The high CEA-producing tumors, SW403 and LS174T, had high tumor uptake (29.5 +/- 5.0 and 51.1 +/- 6.1, respectively). Biodistribution and scintiscan quality were closely related. Although LS174T had the best tumor uptake, SW403 had the highest CEA tumor content, indicating tumor CEA content cannot entirely predict scintiscan and biodistribution results. Tumor-to-blood (T/B), tumor-to-liver (T/L), and liver-to-blood (L/B) ratios were calculated for each animal and compared with tumor size. It was found that T/L had a negative correlation with tumor size (r = -0.72) and L/B had a positive correlation with tumor size (r = 0.94). These ratios may be useful clinically to follow response to therapy. PMID:3942992

Philben, V J; Jakowatz, J G; Beatty, B G; Vlahos, W G; Paxton, R J; Williams, L E; Shively, J E; Beatty, J D

1986-02-01

88

Distinguishing between primary endocervical and endometrial adenocarcinomas: is a 2-marker (Vim/CEA) panel enough?  

PubMed

Gynecological pathologists are used to operating many panels of various markers in combination for the diagnostic distinction between primary endocervical and endometrial adenocarcinomas. The conventional 3-marker (ER/Vim/CEA) panel is the most promising tool. In this study, our aim is to investigate whether a 2-marker panel is enough to distinguish between these two gynecologic malignancies. Additionally, we wish to determine which one is the most favorable among eight panels tested, including six 2-marker (ER/CEA, PR/CEA, Vim/CEA, ER/p16(INK4a), PR/p16(INK4a), Vim/p16(INK4a)) and two 3-marker (ER/Vim/CEA, ER/Vim/p16(INK)) panels. A tissue microarray was constructed using paraffin-embedded, formalin-fixed tissues from 35 hysterectomy specimens, including 14 primary endocervical adenocarcinomas and 21 primary endometrial adenocarcinomas. Utilizing the avidin-biotin complex (ABC) method, tissue array sections were immunostained with five commercially available antibodies (ER, Vim, CEA, PR, and p16(INK4a)) to evaluate their individual frequencies of expression. We found that all eight aforementioned panels showed an encouraging range of overall accuracy (69.2% to 78.3%). However, one panel of 2-markers (Vim, CEA) exhibited the most efficiency (78.3%) in the diagnostic distinction between primary endocervical and endometrial adenocarcinomas. Based on the analyzed data, we conclude that the 2-marker (Vim/CEA) panel seems adequate to be an appropriate, convenient, and efficient means to distinguish between primary endocervical and endometrial adenocarcinomas. Even though there were a limited number of cases, this study still provides valuable references to help avoid wasting resources and unnecessary marker testing. PMID:20221633

Liao, Chiung-Ling; Hsu, Jeng-Dong; Lee, Ming-Yung; Kok, Lai-Fong; Li, Yi-Ju; Wang, Po-Hui; Yao, Chung-Chin; Han, Chih-Ping

2010-04-01

89

Rising CEA levels in a patient with colon carcinoma: metachronous medullary thyroid cancer.  

PubMed

Introduction: Carcinoembryonic antigen (CEA) is a commonly used tumor marker, and its value in colon cancer is well established. However it is overexpressed in many different tumors. Here we report a case of colorectal cancer with high postoperative CEA levels that were associated with medullary thyroid carcinoma. Case: A 60-year old man was operated for colon cancer. Postoperative CEA level was 107.6 ng/mL, while preoperative CEA level was unknown. For the detection of distant metastasis or local recurrence, we performed 18-flouro deoxyglycose (FDG) positron emission tomography (PET) and computed tomography (CT). We observed an increased FDG accumulation in the right lobe of the thyroid. The patient had cystic and non-metabolic lesions in the liver, and started a treatment with FOLFOX regimen. After 3 months of chemotherapy CEA was still as high as 146 ng/mL. There was no pathologic FDG uptake other than the thyroid nodule in PET-CT. Fine needle aspiration of the thyroid nodule revealed a follicular neoplasia. The patient underwent total thyroidectomy and histopathology revealed a medullary thyroid carcinoma. Postoperative CEA levels then lowered to normal ranges. Conclusion: The case we here report was a stage III colorectal cancer with high CEA levels. Our focus on searching a residual/metastatic disease made us blind to other possible explanations; in fact, none of us noticed the thyroid nodule. This case reminds us not to forget that high CEA levels can be associated with conditions other than colon cancer, such as thyroid medullary carcinoma. PMID:24425322

Göksu, Sema Sezgin; Göksu, Ugur A; Gündüz, Seyda; Coskun, Hasan S

2014-01-01

90

Peripheral and mesenteric serum levels of CEA and cytokeratins, staging and histopathological variables in colorectal adenocarcinoma  

Microsoft Academic Search

Abstract AIM: To evaluate,the differences,that exist bet- ween,peripheral,and,mesenteric,serum,levels of carcinoembryonic antigen,(CEA) and cytokeratins,in patients with colorectal adenocarcinoma. METHODS: One hundred,and,thirty-eight patients with colorectal,adenocarcinoma,who,underwent surgery at Hospital São Paulo (Discipline of Surgical Gastroenterology of UNIFESP-EPM) between,December 1993 and March 2000 were,retrospectively analyzed. Differences between,CEA and cytokeratin (TPA-M) levels

Ivan Gregório Ivankovics; Luis César Fernandes; Sarhan Sydeney Saad; Delcio Matos

2008-01-01

91

Predictive value of plasma CEA levels: Preoperative prognosis and postoperative monitoring of patients with colorectal carcinoma  

Microsoft Academic Search

Plasma CEA levels were determined in 280 patients with histologically proven colorectal carcinoma: in 180 once or twice preoperatively\\u000a and repeatedly postoperatively, and in 100 postoperatively only. Preoperative levels correlated directly with surgical-pathologic\\u000a state and inversely with the time of recurrence;i.e., groups of patients with more advanced stage showed higher proportion of elevated CEA levels, and patients with higher levels

Janusz J. Szymendera; Marek P. Nowacki; Andrzej W. Szawlowski; Janina A. Kami?ska

1982-01-01

92

Decommissioning of the Nuclear Licensed Facilities at the Fontenay aux Roses CEA Center  

SciTech Connect

This is a summary of the program for the decommissioning of all the CEA's facilities in Fontenay aux Roses. The particularity of this center is that it is located in a built-up area. Taking into account the particularities of the various buildings and the levels of radioactivity in them, it was possible to devise a coherent, optimized program for the CEA-FAR licensed nuclear facility decommissioning operations.

Jeanjacques, Michel; Piketty, Laurence; Mandard, Lionel; Pedron, Guy; Boissonneau, Jean Francois; Fouquereau, Alain; Pichereau, Eric; Lethuaire, Nathalie; Estivie, David; Binet, Cedric; Meden, Igor [Commissariat a l'Energie Atomique, Direction de l'Energie Nucleaire, Direction deleguee des Activites Nucleaires de Saclay, Departement des Reacteurs et des Services Nucleaires, Service d'Assainissement de Fontenay Aux Roses : 18, route du Panorama, BP6, 92265 Fontenay aux Roses Cedex (France)

2008-01-15

93

A DNA vaccine encoding genetic fusions of carcinoembryonic antigen (CEA) and granulocyte/macrophage colony-stimulating factor (GM-CSF).  

PubMed

The anti-tumor immunologic effects of plasmid DNA vaccines encoding human carcinoembryonic antigen (CEA) fused to mouse granulocyte/macrophage colony-stimulating factor (GM-CSF) were examined. Immunization of C57BL/6 mice with the CEA-GMCSF fusion plasmids in a three injection, high-dose immunization schedule led to T cell and antibody responses specific for CEA. Mice injected with CEA-GMCSF fusion plasmids also developed IgG autoantibodies to GM-CSF. Tumor challenge with the CEA-expressing syngeneic mouse adenocarcinoma line, MC38-CEA-2, showed delayed tumor growth in mice immunized with the CEA-GMCSF fusion plasmids but complete protection in mice immunized with plasmid encoding CEA alone. In contrast, a single low-dose immunization with CEA-GMCSF fusion plasmids provided better tumor protection than low-dose CEA plasmid alone and resulted in lower titers of GM-CSF antibodies. PMID:15652670

Lima, Jose; Jenkins, Connie; Guerrero, Antonio; Triozzi, Pierre L; Shaw, Denise R; Strong, Theresa V

2005-01-26

94

Combustible caramel pour reacteurs de recherche: Experience acquise en fabrication, controles et irradiation du coeur d'osiris  

NASA Astrophysics Data System (ADS)

L'un des aboutissements des différentes actions menées en France concernant la conception, la fabrication et le développement des combustibles nucléaires a été la mise au point par le CEA d'un combustible de type plaque (combustible CARAMEL) susceptible d'être adapté a différentes catégories de réacteurs à eau (réacteur de puissance, propulsion navale, chauffage urbain, pile de recherche). Ces travaux ont été couronnés par la réalisation de tout un coeur et des recharges du réacteur de recherche à hautes performances, Osiris, à Saclay. L'ancien combustible en alliage U Al fortement enrichi a eté remplacé par un combustible caramel de faible enrichissement (7%), non proliférant. Ce nouveau coeur fonctionne avec satisfaction, depuis janvier 1980. Après une brève description des caractéristiques du combustible caramel et de ses principaux avantages, on présente sa fabrication ainsi que l'ensemble des contrôles de qualité auxquels il est soumis. Le programme de qualification ainsi que les principaux résultáts qui en ont été tirés sont exposés. On décrit également le programme de suivi du combustible en pile dont le but est de s'assurer du bon comportement du combustible sous irradiation. Le bon fonctionnement d'Osiris, qui a terminé 11 cycles d'irradiation le 21 avril 1981, a permis de montrer le bien fondé des choix effectués et l'excellent comportement de l'élément combustible dans les conditions pourtant sévères d'un réacteur de recherche à hautes performances.

de Contenson, Ghislain; Foulquier, Henri; Trotabas, Maria; Vignesoult, Nicole; Cerles, Jean-Marie; Delafosse, Jacques

1982-04-01

95

Time fiducial on the LIL facility at CEA/CESTA  

NASA Astrophysics Data System (ADS)

The CEA is currently developing the "Laser Mega Joule "(LMJ), a facility capable of concentrating an extremely high quantity of energy from 240 laser beams on a micro target for a brief moment. The characteristics of the facility have been defined to obtain the temperature and pressure conditions required to reach thermonuclear combustion. The "Ligne d'Intégration Laser" (LIL) is a facility designed to validate the choices adopted for the LMJ. It consists of a basic laser line from the MJL with four identical beams. On the LIL, an experiment consists of a series of laser/material interaction firings. For a given firing, there is a concatenation of the phenomena from the triggering of the physical mechanisms to the recording of the signals on the recording instruments (diagnostics). The interaction gives rise to plasma. One sure method to enable the reconstruction of the events in the course of the experiments involves recording an optic time fiducial signal on the main instruments. This temporary marking makes it possible to reposition in time the signals recorded on the measuring instruments against a point of reference. We present here a prototype that has been developed for the time fiducial of the visible streak cameras : "SYMOD : SYstème de Marquage Optique par Diode laser". The original architecture of the bench is based on the use of one laser diode per diagnosis to be marked. Other components, including synchronization equipment and two chronometry arrays, are arranged around this source which constitutes the main component of the device. Tests have been run to validate the technical choice of the source and to demonstrate that the main time requirements concerning the fiducial are met (rise time < 50ps and time jitter < 16ps rms).

Schiano, Yannick; Bar, Emmanuel; Richard, André; Feral, Christophe; Darquey, Patrick

2007-05-01

96

Evolution and advection of solar mesogranulation  

NASA Technical Reports Server (NTRS)

A three-hour sequence of observations at the Pic du Midi observatory has been obtained which shows the evolution of solar mesogranules from appearance to disappearance with unprecedented clarity. It is seen that the supergranules, which are known to advect the granules with their convective motion, also advect the mesogranules to their boundaries. This process controls the evolution and disappearance of mesogranules.

Muller, Richard; Auffret, Herve; Roudier, Thierry; Vigneau, Jean; Simon, George W.; Frank, Zoe; Shine, Richard A.; Title, Alan M.

1992-01-01

97

Pubalgies et statique du bassin  

Microsoft Academic Search

Conclusion Il est certes difficile de transposer directement les résultats du cadavre au vivant. En outre, les insertions musculaires, très puissantes à ce niveau, modifient certainement les valeurs des contraintes symphysaires. Cependant, notre expérimentation nous paraît démontrer le rôle important de la bascule du bassin dans la détermination des contraintes symphysaires. De faibles variations angulaires entraînent des variations appréciables des

J. J. Rolland; P. Menou; M. Le Bourg; P. Rochcongard; M. Levasseur; F. Chagneau; M. Fofana

1982-01-01

98

Cri du Chat syndrome  

Microsoft Academic Search

The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm\\u000a of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a\\u000a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics,\\u000a and severe psychomotor and mental retardation. Malformations,

Paola Cerruti Mainardi

2006-01-01

99

Multiplex RT-PCR-based detections of CEA, CK20 and EGFR in colorectal cancer patients  

PubMed Central

AIM: To develop a multiplex reverse transcription polymerase chain reaction (RT-PCR) method detecting circulating tumor cells in the peripheral blood of colorectal cancer (CRC) patients. METHODS: Peripheral blood samples were collected from 88 CRC patients and 40 healthy individuals from the blood donors’ clinic and subsequently analyzed by multiplex RT-RCR for the expression of carcinoembryonic antigen (CEA), cytokeratin 20 (CK20) and epidermal growth factor receptor (EGFR) mRNA. The analysis involved determining the detection rates of CEA, CK20 and EGFR transcripts vs disease stage and overall survival. Median follow-up period was 19 mo (range 8-28 mo). RESULTS: Rates of CEA, CK20 and EGFR detection in CRC patients were 95.5%, 78.4% and 19.3%, respectively. CEA transcripts were detected in 3 healthy volunteer samples (7.5%), whereas all control samples were tested negative for CK20 and EGFR transcripts. The increasing number of positive detections for CEA, CK20 and EGFR transcripts in each blood sample was positively correlated with Astler-Coller disease stage (P < 0.001) and preoperative serum levels of CEA (P = 0.029) in CRC patients. Data analysis using Kaplan-Meier estimator documented significant differences in the overall survival of the different CRC patient groups as formed according to the increasing number of positivity for CEA, CK20 and EGFR transcripts. CONCLUSION: These data suggest that multiplex RT-PCR assay can provide useful information concerning disease stage and overall survival of CRC patients.

Tsouma, Aikaterini; Aggeli, Chrysanthi; Lembessis, Panagiotis; Zografos, George N; Korkolis, Dimitris P; Pectasides, Dimitrios; Skondra, Maria; Pissimissis, Nikolaos; Tzonou, Anastasia; Koutsilieris, Michael

2010-01-01

100

Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein  

PubMed Central

Background CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. Methods The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. Results The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. Conclusion The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance.

Pavoni, Emiliano; Flego, Michela; Dupuis, Maria Luisa; Barca, Stefano; Petronzelli, Fiorella; Anastasi, Anna Maria; D'Alessio, Valeria; Pelliccia, Angela; Vaccaro, Paola; Monteriu, Giorgia; Ascione, Alessandro; De Santis, Rita; Felici, Franco; Cianfriglia, Maurizio; Minenkova, Olga

2006-01-01

101

Cancer du sein chez les femmes âgées  

Microsoft Academic Search

Le cancer du sein touche près de 40 000 femmes par an et est responsable de 11 000 décès. Parmi les femmes atteintes 45 %\\u000a ont plus de 65 ans. C’est donc souligner d’emblée l’importance du problème, ne serait-ce qu’au regard du nombre de personnes\\u000a concernées. La fréquence du cancer du sein s’accroît avec l’âge: aux États-Unis il touche 60

Marc Espié

102

Serum carcino-embryonic antigen (CEA) and its possible use as tumor marker for secondary tumors in urinary intestinal reservoirs  

Microsoft Academic Search

ObjectivesSerum carcino-embryonic antigen (CEA) has become a useful tumor marker in patients with colorectal adenocarcinoma. Patients who undergo uroenteric reconstruction, such as urinary diversion (UD), have an increased risk of developing malignant changes in their UD. We compared serum CEA levels in patients with different types of UD, evaluating long-term CEA changes and assessing its potential for use as a

Andreas Loeser; Michael Neumann; Arkardius Kocot; Daniel C. Vergho; Martin Spahn; Hubertus Riedmiller

103

Rapid cytotoxicity of antimicrobial peptide tempoprin-1CEa in breast cancer cells through membrane destruction and intracellular calcium mechanism.  

PubMed

Temporin-1CEa is an antimicrobial peptide isolated from the skin secretions of the Chinese brown frog (Rana chensinensis). We have previously reported the rapid and broad-spectrum anticancer activity of temporin-1CEa in vitro. However, the detailed mechanisms for temporin-1CEa-induced cancer cell death are still weakly understood. In the present study, the mechanisms of temporin-1CEa-induced rapid cytotoxicity on two human breast cancer cell lines, MDA-MB-231 and MCF-7, were investigated. The MTT assay and the LDH leakage assay indicated that one-hour of incubation with temporin-1CEa led to cytotoxicity in a dose-dependent manner. The morphological observation using electronic microscopes suggested that one-hour exposure of temporin-1CEa resulted in profound morphological changes in both MDA-MB-231 and MCF-7 cells. The membrane-disrupting property of temporin-1CEa was further characterized by induction of cell-surface exposure of phosphatidylserine, elevation of plasma membrane permeability and rapid depolarization of transmembrane potential. Moreover, temporin-1CEa evoked intracellular calcium ion and reactive oxygen species (ROS) elevations as well as collapse of mitochondrial membrane potential (??m). In summary, the present study indicates that temporin-1CEa triggers rapid cell death in breast cancer cells. This rapid cytotoxic activity might be mediated by both membrane destruction and intracellular calcium mechanism. PMID:23577112

Wang, Che; Tian, Li-Li; Li, Song; Li, Hui-Bing; Zhou, Yang; Wang, He; Yang, Qing-Zhu; Ma, Li-Jie; Shang, De-Jing

2013-01-01

104

Involvement of circulating CEA in liver metastases from colorectal cancers re-examined in a new experimental model.  

PubMed

Both experimental and clinical data show evidence of a correlation between elevated blood levels of carcinoembryonic antigen (CEA) and the development of liver metastases from colorectal carcinomas. However, a cause-effect relationship between these two observations has not been demonstrated. For this reason, we developed a new experimental model to evaluate the possible role of circulating CEA in the facilitation of liver metastases. A CEA-negative subclone from the human colon carcinoma cell line CO115 was transfected either with CEA-cDNA truncated at its 3' end by the deletion of 78 base pairs leading to the synthesis of a secreted form of CEA or with a full-length CEA-cDNA leading to the synthesis of the entire CEA molecule linked to the cell surface by a GPI anchor. Transfectants were selected either for their high CEA secretion (clone CO115-2C2 secreting up to 13 microg CEA per 10(6) cells within 72 h) or for their high CEA membrane expression (clone CO115-5F12 expressing up to 1 x 10(6) CEA molecules per cell). When grafted subcutaneously, CO115-2C2 cells gave rise to circulating CEA levels that were directly related to the tumour volume (from 100 to 1000 ng ml(-1) for tumours ranging from 100 to 1000 mm3), whereas no circulating CEA was detectable in CO115 and CO115-5F12 tumour-bearing mice. Three series of nude mice bearing a subcutaneous xenograft from either clone CO115-2C2 or the CO115-5F12 transfectant, or an untransfected CO115 xenograft, were further challenged for induction of experimental liver metastases by intrasplenic injection of three different CEA-expressing human colorectal carcinoma cell lines (LoVo, LS174T or CO112). The number and size of the liver metastases were shown to be independent of the circulating CEA levels induced by the subcutaneous CEA secreting clone (CO115-2C2), but they were directly related to the metastatic properties of the intrasplenically injected tumour cells. PMID:10424738

Leconte, A; Garambois, V; Ychou, M; Robert, B; Pourquier, D; Terskikh, A; Mach, J P; Pèlegrin, A

1999-07-01

105

Anti-CEA-functionalized superparamagnetic iron oxide nanoparticles for examining colorectal tumors in vivo.  

PubMed

Although the biomarker carcinoembryonic antigen (CEA) is expressed in colorectal tumors, the utility of an anti-CEA-functionalized image medium is powerful for in vivo positioning of colorectal tumors. With a risk of superparamagnetic iron oxide nanoparticles (SPIONPs) that is lower for animals than other material carriers, anti-CEA-functionalized SPIONPs were synthesized in this study for labeling colorectal tumors by conducting different preoperatively and intraoperatively in vivo examinations. In magnetic resonance imaging (MRI), the image variation of colorectal tumors reached the maximum at approximately 24 h. However, because MRI requires a nonmetal environment, it was limited to preoperative imaging. With the potentiality of in vivo screening and intraoperative positioning during surgery, the scanning superconducting-quantum-interference-device biosusceptometry (SSB) was adopted, showing the favorable agreement of time-varied intensity with MRI. Furthermore, biological methodologies of different tissue staining methods and inductively coupled plasma (ICP) yielded consistent results, proving that the obtained in vivo results occurred because of targeted anti-CEA SPIONPs. This indicates that developed anti-CEA SPIONPs owe the utilities as an image medium of these in vivo methodologies. PMID:24103079

Huang, Kai-Wen; Chieh, Jen-Jie; Lin, In-Tsang; Horng, Herng-Er; Yang, Hong-Chang; Hong, Chin-Yih

2013-01-01

106

Performances of Herschel/PACS Bolometer Arrays and future developments at CEA  

NASA Astrophysics Data System (ADS)

The European Space Agency is building a space telescope to observe the Universe in the Far-IR and sub-millimeter regime of the electromagnetic spectrum. The scientific payload is composed of three instruments. One of them, PACS, is equipped with a novel type of bolometer arrays developed by CEA in the late 90's. We briefly present the PACS Photometer and the architecture of CEA filled bolometer arrays. We accessed the physics of the detectors and thoroughly measured their performances by developing a pragmatic calibration procedure. The Photometer is now calibrated and integrated on the focal plane of the observatory. The launch is scheduled for April 2009. Meanwhile, CEA is working on adapting PACS bolometers to longer wavelength for wide-field ground-based telescopes, and for the future cold-telescope space mission SPICA.

Billot, N.; Rodriguez, L.; Okumura, K.; Sauvage, M.; Agnèse, P.

107

Understanding Harris' understanding of CEA: is cost effective resource allocation undone?  

PubMed

We summarise and evaluate Harris' criticisms of cost-effectiveness analysis (CEA) and the alternative processes he commends to health care decision makers. In contrast to CEA, Harris' asserts that individuals have a right to life-saving treatment that cannot be denied on the basis of their capacity to benefit. We conclude that, whilst Harris' work has challenged the proponents of CEA and quality-adjusted life years to be explicit about the method's indirect discriminatory characteristics, his arguments ignore important questions about what 'lives saved' mean. Harris also attempts to avoid opportunity cost by advocating the same chance of treatment for every person desiring treatment. Using a simple example, we illustrate that an 'equal chances' lottery is not in the interest of any patient, as it reduces the chance of treatment for all patients by leaving some of the health budget unspent. PMID:23393040

Edlin, Richard; McCabe, Christopher; Round, Jeff; Wright, Judy; Claxton, Karl; Sculpher, Mark; Cookson, Richard

2013-01-01

108

Khan Du--A Series.  

National Technical Information Service (NTIS)

Presents an fictional magical character, Khan Du, in different situations to show handicapped children that they can do many things if they develop a positive attitude. Primary audience: Elementary grade students as well as their parents and teachers.

1994-01-01

109

An Information Building on Radioactivity and Nuclear Energy for the French CEA Cadarache Research Center - 13492  

SciTech Connect

The CEA Cadarache research center is one of the 10 research centers of the French Alternative Energies and Atomic Energy Commission (CEA). Distributed throughout various research platforms, it focuses on nuclear fission, nuclear fusion, new energy technologies (hydrogen, solar, biomass) and fundamental research in the field of vegetal biology. It is the most important technological research and development centers for energy in Europe. Considering the sensitive nature of nuclear activities, the questions surrounding the issue of radioactive waste, the nuclear energy and the social, economic and environmental concerns for present and future generations, the French Government asked nuclear actors to open communication and to give all the information asked by the Local Information Commission (CLI) and the public [1]. In this context, the CEA Cadarache has decided to better show and explain its expertise and experience in the area of nuclear energy and nuclear power plant design, and to make it available to stakeholders and to the public. CEA Cadarache receives each year more than 9000 visitors. To complete technical visits of the research facilities and laboratories, a scientific cultural center has been built in 2011 to inform the public on CEA Cadarache research activities and to facilitate the acceptance of nuclear energy in a way suited to the level of knowledge of the visitors. A modern interactive exhibition of 150 m{sup 2} allows visitors to find out more about energy, CEA Cadarache research programs, radioactive waste management and radiological impact on the research center activities. It also offers an auditorium for group discussions and for school groups to discover science through enjoyment. This communication center has received several thousand visitors since its opening on October 2011; the initial results of this experience are now available. It's possible to explain the design of this exhibition, to give some statistics on the number of the visitors, their characteristics and their perception after their center visits. (authors)

Brunel, Guy; Denis, Dominique; Boulet, Alain [Commissariat a l'energie Atomique et aux Energies Alternatives - CEA-Cadarache, DEN/CEACAD/UCAP, 13108 Saint Paul lez Durance Cedex (France)] [Commissariat a l'energie Atomique et aux Energies Alternatives - CEA-Cadarache, DEN/CEACAD/UCAP, 13108 Saint Paul lez Durance Cedex (France)

2013-07-01

110

L'Aventure du LHC  

ScienceCinema

Cette présentation s?adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l?engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

None

2011-10-06

111

Latest pixel size reduction of uncooled IR-FPA at CEA, LETI  

NASA Astrophysics Data System (ADS)

Recent developments at the Infrared Lab (LIR) of CEA, LETI have been concentrated on the pixel size reduction of uncooled infrared detectors. With the support from French company ULIS, we have successfully demonstrated the technological integration of 12?m pixels on a commercial TV-format read-out circuit (VGA-ROIC) supplied by ULIS. The 12?m pixel has been designed, processed and characterized in CEA, LETI and first results showed exceptional performances. This paper presents the characterization and associated imagery results.

Becker, Sebastien; Imperinetti, Pierre; Yon, Jean-Jacques; Ouvrier-Buffet, Jean-Louis; Goudon, Valérie; Hamelin, Antoine; Vialle, Claire; Arnaud, Agnès.

2012-10-01

112

Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer.  

PubMed

Lung cancer is sometimes difficult to differentiate from benign lung diseases expressing nodular shadow in imaging study. We assessed the diagnostic value of two commonly used tumor markers in distinguishing primary lung cancer from benign lung disease. The serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA 21-1) were retrospectively analyzed in 655 lung cancer patients and 237 patients with benign lung disease. The standard cut-off levels of 3.2 ng/mL CEA and 3.5 ng/mL CYFRA 21-1 and twice these respective levels (6.4 ng/mL and 7.0 ng/mL) were used. CEA and CYFRA 21-1 levels were elevated in 32% and 11% of benign lung disease patients, respectively. CEA sensitivity and specificity for lung cancer diagnosis was 69% and 68% respectively, while that for CYFRA 21-1 was 43% and 89%, respectively. Thus, the combined value for the specificity of the two tumor markers was greater than either alone. Patients were grouped depending on their hospital status, and prevalence rates were determined. The prevalence rate of lung cancer in admitted patients was 51%, the prevalence rate of lung cancer in outpatients was 12%, and the prevalence rate of lung cancer identified during health check-ups was 0.1%. Positive predictive values (PPVs) were calculated using Bayes' theorem, and varied with the serum tumor marker and prevalence rate: PPVs of CEA [prevalence rate] were 69.2% [51%], 22.7% [12%], and 0.22% [0.1%], while PPVs of CYFRA 21-1 were 80.3% [51%], 34.8% [12%], and 0.39% [0.1%]. However, PPVs for lung cancer diagnosis at a prevalence rate of 51% were 87.3% or higher when the patient exhibited positive CEA and CYFRA 21-1, or CEA or CYFRA 21-1 levels twice the standard cut-off. Our results indicate that CEA and CYFRA 21-1 are reliable serum tumor markers for the diagnosis of lung cancer in addition to CT scans when combined or used individually at twice the standard cut-off level in high prevalence rate groups. The prevalence rate should therefore be taken into account when these serum tumor markers are used as diagnostic tools for lung cancer. PMID:23352032

Okamura, Kyoko; Takayama, Koichi; Izumi, Miiru; Harada, Taishi; Furuyama, Kazuto; Nakanishi, Yoichi

2013-04-01

113

Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV)-based plasmid vector carrying the CEA promoter.  

PubMed

The present study reports a novel nonviral method to efficiently and specifically target carcinoembryonic antigen (CEA)-producing cholangiocarcinoma (CC) cells in vitro. Epstein-Barr virus (EBV)-based and conventional plasmid vectors were constructed that possess the beta-galactosidase (beta-gal) or herpes simplex virus-1 (HSV-1) thymidine kinase (Tk) genes as well as tandem repeats of the human genomic sequence -82 to -42 bp from the transcriptional start site of the CEA gene. The plasmids were transfected by means of polyamidoamine dendrimer into CEA-positive (HuCC-T1) or -negative cell lines. Transfection of the conventional plasmid vector with the CEA promoter and beta-gal gene resulted in a very low or undetectable level of marker gene expression even in the CEA-positive cell line. Transferring the HSV-1 Tk gene by conventional plasmid did not affect the susceptibility of HuCC-T1 cells to ganciclovir. In marked contrast, strong beta-gal expression was specifically obtained in HuCC-T1 cells by transfecting the EBV-based plasmid in which the CEA promoter and a ubiquitous promoter (SRalpha) are employed to drive the EBV-encoded nuclear antigen 1 (EBNA1) and beta-gal genes, respectively (pTES.beta). Furthermore, CEA-positive but not -negative tumor cells were rendered highly susceptible to ganciclovir when transfected with the EBV-based vector that carries the CEA promoter-EBNA1 and SRalpha-HSV-1 Tk genes (pTES.Tk). These results strongly suggest that the EBV-based plasmid vector/cationic polymer system (EBV/polyplex) equipped with the CEA promoter provides an efficient nonviral method for the targeted gene therapy of CEA-producing malignancies. PMID:11023196

Tanaka, S; Iwai, M; Harada, Y; Morikawa, T; Muramatsu, A; Mori, T; Okanoue, T; Kashima, K; Maruyama-Tabata, H; Hirai, H; Satoh, E; Imanishi, J; Mazda, O

2000-09-01

114

Type Ia supernova SN 2003du: Optical observations  

NASA Astrophysics Data System (ADS)

UBVRI photometry and optical spectra of type Ia supernova SN 2003du obtained at the Indian Astronomical Observatory for nearly a year since discovery are presented. The apparent magnitude at maximum was B=13.53± 0.02 mag, and the colour (B-V)=-0.08± 0.03 mag. The luminosity decline rate, ? m15(B)=1.04± 0.04 mag indicates an absolute B magnitude at maximum of MBmax=-19.34± 0.3 mag and the distance modulus to the parent galaxy as ?=32.89± 0.4. The light curve shapes are similar, though not identical, to those of SNe 1998bu and 1990N, both of which had luminosity decline rates similar to that of SN 2003du and occurred in spiral galaxies. The peak bolometric luminosity indicates that ˜0.9 M? mass of 56Ni was ejected by the supernova. The spectral evolution and the evolution of the Si II and Ca II absorption velocities closely follows that of SN 1998bu, and in general, is within the scatter of the velocities observed in normal type Ia supernovae. The spectroscopic and photometric behaviour of SN 2003du is quite typical for SNe Ia in spirals. A high velocity absorption component in the Ca II (H and K) and IR-triplet features, with absorption velocities of ˜20 000 km s-1 and ˜22 000 km s-1 respectively, is detected in the pre-maximum spectra of days -11 and -7.

Anupama, G. C.; Sahu, D. K.; Jose, J.

2005-01-01

115

Évolution historique du prisme littoral du lido de l'étang de Thau (Sète, Sud-Est de la France). Mise en évidence par sismique réflexion très haute résolutionHistorical evolution of the littoral prism of the Thau lagoon barrier (Sète, South-East France). Very high-resolution reflection seismic investigation.  

NASA Astrophysics Data System (ADS)

Very high-resolution seismic data have been obtained recently, in the framework of the research programme PNEC (French National Programme of Coastal Environment), on the shoreline area of Sète (Mediterranean coast, South East France). These data provide an accurate picture of the internal structure of the shoreline body. Seismic results combined with data about the morphosedimentary evolution of the study area, vibrocore data and results from archaeological investigations yield clues to the historical evolution of the study area. Especially, it is pointed out that the functioning of the present-day shoreline, by comparison with the system built in classical times, is characterized by a severe reduction in sediment supply and in volumes of sand involved in the shoreline dynamics.

Tessier, Bernadette; Certain, Raphaël; Barusseau, Jean-Paul; Henriet, Jean-Pierre

2000-12-01

116

Iodine-131 labeled anti-CEA polyclonal antibody detection of gastrointestinal cancer  

SciTech Connect

To localize gastrointestinal tumor, 31 patients were injected with 1.7-2.1 mCi I-131 anti-CEA baboon polyclonal antibody. Whole body imaging at 48, 72, and occasionally 96 hrs was performed with a Signa Camera (Technicare) peaked at 364 keV with 20% window. Additional spot views were usually obtained. No subtraction methods were used. All patients had surgical and pathological confirmation of the nuclear medicine studies. Labeled antibody images were positive in 15 (8 recurrent or metastatic colorectal, 2 gastric, 1 pancreatic, 1 primary colon, and 1 breast metastatic to chest wall). In 1, antibody images were positive for metastatic deposits in para-aortic lymph nodes, but negative for primary rectal tumor. True negative images were observed in 6; false negative images in 9 (4 liver metastases, 2 rectal, 1 pancreatic, 1 mesenteric lymph node metastasis, 1 bone metastasis). In all cases, no correlation existed between preoperative CEA serum levels and imaging. I-131 labeled anti-CEA polyclonal antibody imaging proved highly efficient in detecting gastric cancer (2/2) and moderately efficient in detecting recurrent colorectal cancer (8/15). On the other hand, the I-131 labeled polyclonal anti-CEA antibody imaging was of limited value in detecting colon cancer (1/9), pancreatic cancer (1/4) and metastatic liver disease (0/4).

Nabi, H.A.; Hinkle, G.H.; Olsen, J.O.; Haagensen, D.A.; Thurston, M.O.; Mojzisik, C.; Houchens, D.; Martin, E.W. Jr.

1984-01-01

117

Spanish Pre-University Students' Use of English: CEA Results from the University Entrance Examination  

ERIC Educational Resources Information Center

In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA) (Dagneaux, Denness & Granger, 1998) was conducted on a representative sample of the students who took the exam in June 2008 in Jaen, and…

Diez-Bedmar, Maria Belen

2011-01-01

118

AMS/CEA Joint Aerial Campaign. Nevada Test Site. AMS Data Analysis Procedure.  

National Technical Information Service (NTIS)

The United States NNSA AMS (Aerial Measuring Systems) and the French Commissariat a lEnergie Atomique (CEA) participated in joint aerial survey activities during the period November 6-19, 2007. Survey activities were conducted near Las Vegas, Nevada, and ...

J. Stampahar T. J. Hendricks

2009-01-01

119

Latest achievements of CEA and AREVA NP on HTR fuel fabrication  

Microsoft Academic Search

Extensive research and development programs on the (Very) High Temperature gas cooled Reactor (V\\/HTR) are being conducted by many countries mainly promoted by the attractiveness of this concept and its capability for other applications than electricity production, such as high temperature process heat and cogeneration. In this international context, the Commissariat à l’Energie Atomique (CEA) and AREVA NP through its

François Charollais; Christophe Perrais; Dominique Moulinier; Marc Perez; Marie-Pierre Vitali

2008-01-01

120

Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients  

PubMed Central

Background: The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients. Methods: All patients (n=504) undergoing a resection for stage I–III rectal cancer at the Kantonsspital St Gallen were included into a database between 1991 and 2008. The impact of preoperative CEA level on overall survival was assessed using risk-adjusted Cox proportional hazard regression models and propensity score methods. Results: In risk-adjusted Cox proportional hazard regression analyses, preoperative CEA level (hazard ratio (HR): 1.98, 95% confidence interval (CI): 1.36–2.90, P<0.001), distance from anal verge (<5?cm: HR: 1.93, 95% CI: 1.11–3.37; P=0.039), older age (HR: 1.07, 95% CI: 1.05–1.09; P<0.001), lower body mass index (HR: 0.94, 95% CI: 0.89–0.98; P=0.006), advanced tumour stage (stage II HR: 1.41, 95% CI: 0.85–2.32; stage III HR: 2.08, 95% CI: 1.31–3.31; P=0.004), R 1 resection (HR: 5.65, 95% CI: 1.59–20.1; P=0.005) and chronic kidney disease (HR: 2.28, 95% CI: 1.03–5.04; P=0.049) were all predictors for poor overall survival. Conclusion: This is one of the first investigations based on a large cohort of exclusively rectal cancer patients demonstrating that preoperative CEA level is a strong predictor of decreased overall survival. Preoperative CEA should be used as a prognostic factor in the preoperative assessment of rectal cancer patients.

Tarantino, I; Warschkow, R; Worni, M; Merati-Kashani, K; Koberle, D; Schmied, B M; Muller, S A; Steffen, T; Cerny, T; Guller, U

2012-01-01

121

Improving tumor targeting and therapeutic potential of Salmonella VNP20009 by displaying cell surface CEA-specific antibodies  

PubMed Central

Genetically modified Salmonella typhimurium VNP20009 (VNP) is a useful vehicle for cancer therapy and vaccine development but exhibits limited tumor targeting in vivo. We engineered a novel VNP derivative that expressed carcinoembryonic antigen (CEA)-specific single chain antibody fragments (scFv) on the cell surface to increase tumor-specific targeting. There was significant scFv cell surface display visualized by flow cytometry and confocal microscopy when cells were probed with fluorescently labeled CEA. Atomic force microscopy (AFM) measurements on whole bacteria confirmed binding of unlabelled CEA to the displayed scFv. The modified VNP strain exhibited increased localization in the upper gastrointestinal tract of CEA transgenic mice and accumulated in CEA-expressing tumors. Furthermore, treatment with a single dose of the VNP derivative inhibited growth of MC38CEA tumors and was associated with local accumulation of CD3+ T cells and CD11b+ macrophages. The display of antibody fragments on the surface of VNP represents a novel strategy for both targeting CEA-expressing tumors and increasing the immunogenicity of Salmonella-based vaccines for cancer.

Bereta, Michal; Hayhurst, Andrew; Gajda, Mariusz; Chorobik, Paulina; Targosz, Marta; Marcinkiewicz, Janusz; Kaufman, Howard L.

2009-01-01

122

DuPont hikes butanediol  

SciTech Connect

Butanediol (BDO) and its derivatives continue to be strong, a positive sign for the many companies planning expansions. DuPont - one of only two global producers not planning capacity additions - has announced that it will discontinue all off-schedule pricing for BDO and two important derivatives, tetrahydrofuran (THF) and polytetramethylene ether glycol (PTMEG). DuPont`s list prices are $1.00/lb fob for BDO, about $1.40/lb for THF, and $2.00/lb for PTMEG. The price adjustment is effective this month or as contracts allow.

Morris, G.D.L.

1997-05-14

123

[Examination of the patient serum presenting a CEA false high value after cancer immuno-cell therapy].  

PubMed

False positive elevation of carcinoembryonic antigen (CEA) was observed in a 65-year-old woman who was treated with dendritic cell therapy (DCT) and activated lymphocyte therapy (ALT) for intrahepatic cholangiocarcinoma. Three months after the initiation of these therapies, her CEA value measured by AIA (TOSOH) began to increase without any evidence of worsening of cholangiocarcinoma. CEA was measured by several different methods, and only the result measured by AIA was high, indicating the presence of a false positive phenomenon. To clarify this phenomenon, we evaluated the patient's serum precisely. Gel filtration chromatography of her serum showed that CEA was detected in the elution fraction of IgG, which was different from the reference samples. Furthermore, this peak disappeared after incubation of patient's CEA and HBR-1. The immunoglobulin absorption test revealed that CEA value was decreased only after absorption of IgG and absorption tests using HBR-1 and MAK-absorbents showed a dramatic decrease in CEA value. These findings indicated the presence of IgG type human anti-mouse antibodies (HAMA), which interfered the measurement by AIA. Although we could not identify the reason why HAMA was produced in this patient, the facts that the false positive phenomenon was observed after the initiation of DCT and ALT, and that CEA value decreased after theses therapies were discontinued, indicated that immuno-modulaton by DCT and ALT may have a close relationship to HAMA production. It was probable that DCT and ALT activated preexisting heterophile-antibody-producing cells, which stimulated HAMA production. The incidence of such false positive reaction of CEA by HAMA in patients with DCT and ALT was low, but as the number of the patient with immuno-cell therapy increases, the incidence of such phenomenon surely increases. Because HAMA reacts to all types of immunoassay, careful attention should be paid to the evaluation of laboratory findings in patients undergoing with such immuno-cell therapies. PMID:21942086

Abe, Masaki; Matsuura, Tomokazu; Hyoki, Miyuki; Abe, Ikurou; Tanigawa, Keishi; Kaito, Ken

2011-08-01

124

Cri du Chat syndrome  

PubMed Central

The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and mental retardation. Malformations, although not very frequent, may be present: cardiac, neurological and renal abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism. Molecular cytogenetic analysis has allowed a cytogenetic and phenotypic map of 5p to be defined, even if results from the studies reported up to now are not completely in agreement. Genotype-phenotype correlation studies showed a clinical and cytogenetic variability. The identification of phenotypic subsets associated with a specific size and type of deletion is of diagnostic and prognostic relevance. Specific growth and psychomotor development charts have been established. Two genes, Semaphorin F (SEMAF) and ?-catenin (CTNND2), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in CdCS patients. Deletion of the telomerase reverse transcriptase (hTERT) gene, localised to 5p15.33, could contribute to the phenotypic changes in CdCS. The critical regions were recently refined by using array comparative genomic hybridisation. The cat-like cry critical region was further narrowed using quantitative polymerase chain reaction (PCR) and three candidate genes were characterised in this region. The diagnosis is based on typical clinical manifestations. Karyotype analysis and, in doubtful cases, FISH analysis will confirm the diagnosis. There is no specific therapy for CdCS but early rehabilitative and educational interventions improve the prognosis and considerable progress has been made in the social adjustment of CdCS patients.

Cerruti Mainardi, Paola

2006-01-01

125

Classification mol?culaire du cancer du sein au Maroc  

PubMed Central

Introduction La classification moléculaire des cancers du sein basée sur l'expression génique puis sur le profil protéique a permis de distinguer cinq groupes moléculaires: luminal A, luminal B, Her2/neu, basal-like et non-classées. L'objectif de cette étude réalisée au CHU Hassan II de Fès est de classer 335 cancers du sein infiltrant en groupes moléculaires, puis de les corréler avec les caractéristiques clinicopathologiques. Méthodes Etude rétrospective étalée sur 45 mois, comportant 335 patientes colligées au CHU pour le diagnostic et le suivi. Les tumeurs sont analysées histologiquement et classées après une étude immunohistochimique en groupes: luminal A, luminal B, Her2+, basal-like et non-classées. Résultats 54.3% des tumeurs sont du groupe luminal A, 16% luminal B, 11.3% Her2+, 11.3% basal-like et 7% non-classées. Le groupe luminal A renferme le plus faible taux de grade III, d'emboles vasculaires ainsi que de métastases; alors que le groupe des non-classées et basal-like représentent un taux élevé de grade III, une faible proportion d'emboles vasculaires et d'envahissement ganglionnaire. Ces facteurs sont significativement élevés dans les groupes luminal B et Her2+ avec un taux de survie globale de 78% et 76% respectivement. Dans le groupe luminal A, la survie globale des patientes est élevée (87%) alors qu'elle n'est que de 49% dans le groupe des triples négatifs (basal-like et non-classés). Conclusion Le groupe luminal B est différent du luminal A et il est de pronostic péjoratif vis à vis du groupe Her2+. Les caractéristiques clinicopathologiques concordent avec le profil moléculaire donc devraient être pris en considération comme facteurs pronostiques.

Fouad, Abbass; Yousra, Akasbi; Kaoutar, Znati; Omar, El Mesbahi; Afaf, Amarti; Sanae, Bennis

2012-01-01

126

CEA-negative glioblastoma and melanoma cells are sensitive to cytosine deaminase/5-fluorocytosine therapy directed by the carcinoembryonic antigen promoter.  

PubMed

Recent studies have suggested that carcinoembryonic antigen (CEA)-promoter sequences are active only in CEA-positive cells, filing in the criteria for tumor specific targeting of suicide genes. However, the present study on gene therapy of colon cancer and cell-specificity of CEA promoter, provide evidence that CEA-positive and CEA-negative cells transfected with E. coli cytosine deaminase (CD) gene under the control of CEA promotor sequence are sensitive to enzyme/pro-drug therapy with 5-fluorocytosine (5-FC). Individual clones derived from the CEA-negative cell lines: melanoma Hs294T and glioblastoma T98G after transfection with CD differed profoundly in their sensitivity to 5-FC. The IC50 values for several clones of the CEA-negative cells were almost the same as for CEA-positive colon cancer cells. Such 5-FC-sensitive clones derived from the population of CEA-negative cells, present even in small number, because of the very effective bystender effect of this enzyme/pro-drug system can cause severe problems during therapy by efficiently killing surrounding normal cells. Safety is the major issue in gene therapy. Our data suggest that the safety of gene-directed enzyme pro-drug therapy (GDEPT) with CEA promoter driven expression of therapeutic genes is not so obvious as it has originally been claimed. PMID:15448734

Dabrowska, Anna; Szary, Jaros?aw; Kowalczuk, Ma?gorzata; Szala, Stanis?aw; Ugorski, Maciej

2004-01-01

127

Du Pont Information Flow System  

ERIC Educational Resources Information Center

The Information Flow System is a large-scale information retrieval system developed for processing of Du Pont information files. As currently implemented, the system stores and retrieves information on company technical reports. Extensions of the system for handling chemical structure information and on-line processing are also discussed. (3…

Hoffman, Warren S.

1972-01-01

128

The cri du chat syndrome  

Microsoft Academic Search

Data for 331 cri du chat cases, including 34 Danish probands, are reviewed. The incidence and the prevalence among the mentally retarded population amounted to 1\\/45,000 and 1.5\\/1000, respectively. No striking association with prenatal events, parental ages, or birth order could be demonstrated. There was a significant excess of females.

E. Niebuhr

1978-01-01

129

Khan Du--A Series.  

National Technical Information Service (NTIS)

The videos present Khan du, a magical wizard, in different situations, to show handicapped children that they can do many things if they develop a positive attitude. The primary audience is elementary grade children as well as their parents, and teachers.

1994-01-01

130

TSV processing of Medipix3 wafers by CEA-LETI: a progress report  

NASA Astrophysics Data System (ADS)

The next generation of hybrid pixel detectors in particle physics experiments require reduced material budget, increased interconnection density and, ideally, they should be tileable to cover large areas seamlessly. These criteria cannot be fulfilled with present day interconnection techniques. As a result the particle physics community has recently put in a lot of effort to investigate and evaluate a variety of novel interconnection technologies. This paper focuses on describing a recently launched Through Silicon Via process development project with CEA-LETI. The project aims to use Medipix3 wafers and an existing ``via last'' TSV process made available by CEA-LETI to demonstrate the feasibility of TSVs on functional detector chips. The status of the project, TSV design and future plans are presented.

Tick, T.; Campbell, M.

2011-11-01

131

Comparison of CEA hydroacoustic bulletin and IDC hydroacoustic monitoring in the Pacific  

NASA Astrophysics Data System (ADS)

The Laboratoire de géophysique, french Commissariat à l'Energie Atomique, in French Polynesia, uses to edit an annual hydroacoustic bulletin of seismic activity in the Pacific. From this bulletin, we present the locations of hydroacoustic sources detected in 2008 in the Pacific by the french 'T phase' stations network. Locations are obtained from the synergy of hydroacoustic and seismic Rayleigh phases pickings which enable a highly constrained localization. This set of data is compared with the distribution of seismic sources published in the IDC REB seismic bulletin containing T phase pickings. We particularly study the localization of a submarine explosion off the east coast of Japan. We compare the location parameters and errors obtained with IMS waveforms data, with both IMS and french CEA waveforms data and the best location obtained with japanese, french CEA and CTBT data.

Hyvernaud, O.; Reymond, D.

2009-12-01

132

Primary mucinous adenocarcinoma of the renal pelvis with elevated CEA and CA19-9.  

PubMed

Primary adenocarcinoma of the renal pelvis is rarely reported in the literature. Here we present a case of primary mucinous adenocarcinoma of the renal pelvis with elevated serum carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels. A 56-year-old woman was referred to our center with intermittent fever and left-sided back pain for 1 month. Computed tomography showed bilateral nephrolithiasis, mild right hydronephrosis and left pyonephrosis accompanied with ambiguous soft tissues. A radionucleorenogram showed that the glomerular filtration rate of the left and right kidney was 0 and 79 ml/min, respectively. Left nephrectomy was performed without lymph node dissection. Histopathology revealed mucinous adenocarcinoma and elevated serum CEA and CA19-9 levels were found. She died of multiorgan metastasis after 5 months. A review of the literature is also reported. PMID:21893942

Ye, Yun-Lin; Bian, Jun; Huang, Yan-Ping; Guo, Yan; Li, Zhi-Xun; Deng, Chun-Hua; Dai, Yu-Ping; Sun, Xiang-Zhou

2011-01-01

133

Enhanced power generation and energy conversion of sewage sludge by CEA-microbial fuel cells.  

PubMed

The production of methane from sewage sludge through the use of anaerobic digestion has been able to effectively offset energy costs for wastewater treatment. However, significant energy reserves are left unrecovered and effluent standards are not met necessitating secondary processes such as aeration. In the current study a novel cloth-electrode assembly microbial fuel cell (CEA-MFC) was used to generate electricity from sewage sludge. Fermentation pretreatment of the sludge effectively increased the COD of the supernatant and improved reactor performance. Using the CEA-MFC design, a maximum power density of 1200mWm(-2) was reached after a fermentation pre-treatment time of 96h. This power density represents a 275% increase over those previously observed in MFC systems. Results indicate continued improvements are possible and MFCs may be a viable modification to existing wastewater treatment infrastructure. PMID:24912141

Abourached, Carole; Lesnik, Keaton Larson; Liu, Hong

2014-08-01

134

Automation of Pic du Midi 2-m Telescope Bernard Lyot  

NASA Astrophysics Data System (ADS)

Since 2007, Pic du Midi 2-m Telescope Bernard Lyot is dedicated to spectropolarimetry with a scientific niche in stella magnetism. In parallel, TBL is progressively evolving from an analogic human-controlled telescope, to a fully automated computer controlled digital telescope. This evolution required TBL team to replace all electronics and motors with digital system (parvex, brushless motors, buscan) components, and to integrate the dataflow system from proposal to archiving into a fully coordinates, remote-access software suite. A trained technician can already control remotely the telescope, instrument and science programs from anywhere. Further robotisation will require a high-level expert system to be defined.

Lavie-Cambot, Jean-Marie; Lacassagne, F.; Ambert, P.; Arrotis, J.-M.; Argentin, Y.; Arberet, M.-P.; Chereau, E.; Decha, C.; Delaigue, C.; Guesdon, L.; Laurent-Burguiere, D.; Malbreil, G.

2011-03-01

135

Pressure drop measurements of prototype NET and CEA cable-in-conduit conductors (CICCs)  

Microsoft Academic Search

The pressure drop of two prototype cable-in-conduit conductors (CICCs) were measured. The NET conductor is a conventional type CICC, while the CEA conductor has a central flow channel to reduce hydraulic impedance. The pressure drop measurements were conducted with helium at temperatures ranging from 2 K to 4.7 K, and pressure from the saturated vapor pressure to in excess of

R. Maekawa; M. R. Smith; S. W. Van Sciver

1995-01-01

136

Serum Level of CA15.3 and CEA in Women Affected with Breast Cancer  

Microsoft Academic Search

s: The tumor marker CA15.3 is the most specific indicator of breast cancer ever known. CEA as the first tumor marker discovered, has been applied in following the patients' responses to different types of treatment for cancer. This study was carried out to assess the serum level of these two markers in the breast cancer patients. In this cross-sectional descriptive

S. M. Ghoraishian; B. A. Jalali; M. R. Mozayan

137

Serial CEA assays and liver scintigraphy for the detection of hepatic metastases from colorectal carcinoma  

Microsoft Academic Search

Of 340 patients with histologically proven colorectal carcinoma, hepatic metastases were diagnosed in 90 (26 per cent), in\\u000a 50 at the time of initial surgery (synchronously) and in 40 during the postoperative follow-up (metachronously). At the time\\u000a of initial surgery, plasma carcinoembryonic antigen (CEA) levels were markedly elevated in patients with synchronous metastases\\u000a and normal or only moderately elevated in

Janusz J. Szymendera; Janina E. Wilczy?ska; Marek P. Nowacki; Janina A. Kaminska; Andrzej W. Szaw?owski

1982-01-01

138

Comparison of Calculational Schemes CITATION (CNEN) and CODNUC (CEA) for the Neutronic Parameters of a Superphenix Type Nuclear Power Plant.  

National Technical Information Service (NTIS)

A comparison is made between the French calculational scheme (CODNUC), currently used at CEA for neutronic studies, and the CNEN one (CITATION). The job task is to collect information about the coherence between the results of optimization calculations, s...

J. C. Cabrillat R. Conversano G. Furini J. M. Vandeborre

1980-01-01

139

Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical, histopathologic, and immunohistochemical findings  

SciTech Connect

A prospective clinical study of 17 patients with a histologic diagnosis of colorectal carcinoma proved at colonoscopy and surgery was performed with indium-111 anticarcinoembryonic-antigen (CEA) monoclonal antibody (MoAb), ZCE-025. MoAb scanning depicted nine of 16 primary colorectal carcinomas on planar scintigrams (true-positive findings = 56%) and ten of 16 lesions on single-photon emission computed tomography (SPECT) scans (true-positive findings = 62%). Liver metastases were detected in three of three patients, and lymph node metastases were detected in one of four patients. Immunohistochemical examination for CEA in resected colorectal cancer tissues demonstrated a positive correlation between MoAb imaging of primary lesions and cytoplasmic-stromal intracellular CEA distribution. There was no correlation between CEA serum levels and lesion detectability with MoAb scanning.

Abdel-Nabi, H.H.; Schwartz, A.N.; Goldfogel, G.; Ortman-Nabi, J.A.; Matsuoka, D.M.; Unger, M.W.; Wechter, D.G.

1988-03-01

140

Aeroacoustics research in Europe: The CEAS-ASC report on 2011 highlights  

NASA Astrophysics Data System (ADS)

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2011, compiled from information provided to the ASC of the CEAS. During 2011, a number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarized in this paper, as well as highlights from other programmes funded by national programmes or by industry. Furthermore, a concise summary of the CEAS-ASC workshop "Acoustic Liners and Associated Propagation Techniques" held in Lausanne in October 2011 is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

McAlpine, A.; Astley, R. J.

2012-10-01

141

Serum levels of CEA and CA15-3 in different molecular subtypes and prognostic value in Chinese breast cancer.  

PubMed

The prognostic significance of preoperative carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) levels in breast cancer is controversial. This study evaluated the prognostic value of preoperative serum CEA and CA15-3 levels in Chinese breast cancer patients. A total of 470 patients with breast cancer had preoperative CEA and CA15-3 concentrations measured. The relationships between preoperative concentration and clinicopathological factors and outcomes were determined. CEA and CA15-3 levels were increased in 34 (7.2%) and 58 (12.3%) patients, respectively. Elevations of serum CEA and CA-15-3 levels correlated with the primary tumor size and axillary lymph node status. CEA levels were lower in patients with triple-negative breast cancer than in those with other subtypes (P = 0.002). The 5-year distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) of CEA-negative vs. CEA-positive patients were 84.1% vs. 54.5% (P < 0.001), 82.7% vs. 54.8% (P < 0.001), and 89.7% vs. 78.5% (P = 0.007), respectively. The 5-year DMFS, DFS, and OS of CA15-3-negative vs. CA15-3-positive patients were 84.0% vs. 69.6% (P = 0.002), 83.0% vs. 66.2% (P < 0.001), 90.9% vs. 74.2% (P = 0.005), respectively. Multivariate analysis of prognosis indicated that CEA and CA15-3 levels were independent prognostic factors for DMFS (P = 0.021) and DFS (P = 0.032), and DFS (P = 0.014) and OS (P = 0.032), respectively. Serum levels of CEA and CA15-3 may differ in breast cancer molecular subtypes and preoperative levels of CEA and CA15-3 have a significant effect on prognosis in Chinese women with breast cancer. PMID:24291374

Wu, San-gang; He, Zhen-yu; Zhou, Juan; Sun, Jia-yuan; Li, Feng-yan; Lin, Qin; Guo, Ling; Lin, Huan-xin

2014-02-01

142

Glycoprotein tumour markers in head and neck neoplasms —a consecutive study on CA50, CA 19-9, and CEA  

Microsoft Academic Search

Summary Serum levels of three glycoprotein tumour antigens (carcino-embryonic antigen, CEA; cancer-associated antigen 50, CA-50; gastrointestinal cancer-associated antigen, CA 19-9) were determined on 125 consecutive patients with tumours of the head and neck region. Elevated CEA values (> 5 units\\/ml) were found in 13\\/70 squamous cell carcinomas, 3\\/21 benign and 4\\/18 malignant salivary gland neoplasms. Elevated CA-50 values (> 17

Hans Gustafsson; Lars Franzén; Kjell Grankvist; Matti Anniko; Roger Henriksson

1988-01-01

143

Fusion of Gaussia Luciferase to an Engineered Anti-carcinoembryonic Antigen (CEA) Antibody for In Vivo Optical Imaging  

Microsoft Academic Search

The bioluminescent protein Gaussia luciferase (GLuc) was fused to an anti-carcinoembryonic antigen (CEA) antibody fragment, the diabody, for in vivo optical tumor imaging. A 15-amino acid N-terminal truncation (GL?15) resulted in a brighter protein. Fusions of the anti-CEA\\u000a diabody to full-length GLuc and GL?15 retained high affinity for the antigen, emitted light, and exhibited excellent enzymatic\\u000a stability. In vivo optical

Katy M. Venisnik; Tove Olafsen; Sanjiv S. Gambhir; Anna M. Wu

2007-01-01

144

Clinical significance of the preoperative plasma carcinoembryonic antigen (CEA) level in patients with carcinoma of the large bowel  

Microsoft Academic Search

Preoperative levels of perchloric acid extractable plasma CEA were measured in 911 patients with complaints of the digestive\\u000a system. A final diagnosis of benign disease was made for 579 patients; 332 patients were found to have cancer. Data for the\\u000a preoperative CEA values were examined for clinical significance as an aide to diagnosis, preoperative disease staging, and\\u000a prognosis.\\u000a \\u000a The results

Karl E. Blake; Milton H. Dalbow; Joseph P. Concannon; Sheila E. Hodgson; George J. Brodmerkel; Hassan Panahandeh; Karl Zimmerman; James J. Headings

1982-01-01

145

Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog  

Microsoft Academic Search

BACKGROUND: Although the impact of pathogens on the evolution of the mammalian immune system is still under debate, proteins, which both regulate immune responses and serve as cellular receptors for pathogens should be at the forefront of pathogen-driven host evolution. The CEA (carcinoembryonic antigen) gene family codes for such proteins and indeed shows tremendous species-specific variation between human and rodents.

Robert Kammerer; Tanja Popp; Stefan Härtle; Bernhard B Singer; Wolfgang Zimmermann

2007-01-01

146

Recurrence pattern and rapid intraoperative detection of carcinoembryonic antigen (CEA) mRNA in pleural lavage in patients with non-small cell lung cancer (NSCLC).  

PubMed

A positive finding on intraoperative pleural lavage cytology (PLC) is considered a possible prognostic factor in patients non-small cell lung cancers (NSCLCs). Patients negative for cancer cells on PLC, however, have occasionally developed recurrence after surgery. In this study, we evaluated the significance of the rapid intraoperative detection of carcinoembryonic antigen-mRNA(mCEA) in pleural lavage in patients with NSCLCs for detecting subclinical recurrence. In 298 NSCLC patients, PLC and mCEA expression of the cell fraction in pleural lavage fluids was analyzed immediately after thoracotomy. The results of mCEA detection by the transcription reverse transcription concerted (TRC) quantitative method and PLC with reference to clinicopathologic characteristics and recurrence patterns were analyzed. The TRC analysis was completed within 90 minutes. Eighty-seven patients (30.9%) were mCEA-positive, and 8(2.7%) were PLC-positive and all mCEA-positive. The positive mCEA rates were not significantly associated with histology or the serum CEA level. Patients with positive the mCEA results showed higher recurrence rates than the mCEA-negative group (5-11%). Thus, intraoperative mCEA analysis by the TRC method should be considered as a sensitive aid to assessing the microscopic spread of malignant cells into the pleural cavity in association with recurrence. PMID:19068780

Sugai, Sachiko; Satoh, Yukitoshi; Komatsu, Miki; Okumura, Sakae; Nakagawa, Ken; Ishikawa, Yuichi; Miki, Yoshio

2008-10-01

147

Marx, organisation et exploitation du travail  

Microsoft Academic Search

Ce texte expose les principaux traits de l'analyse par Marx du procès capitaliste d'exploitation de la force de travail. Après avoir rappelé ce qu'est la théorie de l'exploitation, les notions de coopération simple et de travailleur collectif permettent d'identifier le double aspect du commandement dans la production capitaliste. Dans la manufacture, où la subordination du travail est tout d'abord formelle,

Bruno Tinel

2005-01-01

148

Le mythe du nouveau consommateur  

Microsoft Academic Search

[fre] L'année 1973 a indéniablement marqué un bouleversement du paysage économique et social de notre pays. Le consommateur ne pouvait que s'adapter à ce changement. De quelle manière l'a-t-il fait? En ce qui concerne l'automobile, on a assisté à une chute des achats neufs jusqu'au milieu de 1975, suivie d'une remontée sensible. Le profil des dépenses énergétiques des ménages est

Alain Trognon; Philippe LHardy

1980-01-01

149

Un conte de trois villes : la dynamique du secteur de la fabrication a Toronto, a Montreal et a Vancouver de 1976 a 1997  

Microsoft Academic Search

Selon certains travaux de recherche recents, l'investissement se serait deplace des regions urbaines vers des localites plus rurales. Toutefois, la fabrication au Canada demeure une activite essentiellement urbaine, plus de 40 % de l'emploi dans le secteur de la fabrication se trouvant dans les trois plus grandes regions urbaines du Canada. Le present document examine l'evolution du secteur de la

Tara Vinodrai

2001-01-01

150

Comparative imaging and biodistribution studies with an anti-CEA monoclonal antibody and its F(ab) 2 and Fab fragments in mice with colon carcinoma xenografts  

Microsoft Academic Search

An IgG1 mouse monoclonal antibody directed against CEA has been digested with papain to yield F(ab)2 and Fab fragments. Following radioiodination, intact antibody and fragments showed specific binding to cells of a CEA-producing tumour, although the immune reactivities of the fragments were lower than that of intact antibody. Gamma scintigraphy of nude mice bearing CEA-producing human tumour xenografts and injected

Sarah M. Andrew; Malcolm V. Pimm; Alan C. Perkins; Robert W. Baldwin

1986-01-01

151

A label-free electrochemical immunoassay for carcinoembryonic antigen (CEA) based on gold nanoparticles (AuNPs) and nonconductive polymer film  

Microsoft Academic Search

A simple and sensitive label-free electrochemical immunoassay electrode for detection of carcinoembryonic antigen (CEA) has been developed. CEA antibody (CEAAb) was covalently attached on glutathione (GSH) monolayer-modified gold nanoparticle (AuNP) and the resulting CEAAb–AuNP bioconjugates were immobilized on Au electrode by electro-copolymerization with o-aminophenol (OAP). Electrochemical impedance spectroscopy and cyclic voltammetry studies demonstrate that the formation of CEA antibody–antigen complexes

Hao Tang; Jinhua Chen; Lihua Nie; Yafei Kuang; Shouzhuo Yao

2007-01-01

152

Coherent investigation of nuclear data at CEA DAM: Theoretical models, experiments and evaluated data  

NASA Astrophysics Data System (ADS)

The domain of evaluated nuclear data involves at the same time, a close interaction between the field of nuclear applications and that of nuclear physics, and a close interaction between experiments and theory. The final product, the evaluated data file, synthesises vast amounts of information stemming from all of the above fields. In CEA DAM, all these aspects of nuclear data are investigated in a consistent way, making full use of experimental facilities and high-performance computing as well as numerous national and international collaborations, for the measurement, calculation, evaluation, and validation of nuclear data.

Bauge, E.; Bélier, G.; Cartier, J.; Chatillon, A.; Daugas, J. M.; Delaroche, J. P.; Dossantos-Uzarralde, P.; Duarte, H.; Dubray, N.; Ducauze-Philippe, M.; Gaudefroy, L.; Gosselin, G.; Granier, T.; Hilaire, S.; Chau, Huu-Tai P.; Laborie, J. M.; Laurent, B.; Ledoux, X.; Le Luel, C.; Méot, V.; Morel, P.; Morillon, B.; Roig, O.; Romain, P.; Taieb, J.; Varignon, C.; Authier, N.; Casoli, P.; Richard, B.

2012-08-01

153

R and D Programs and Policy within the CEA-AREVA Joint Vitrification Lab (LCV) - 13592  

SciTech Connect

Waste management is a key issue for the reprocessing industry; furthermore, vitrification is considered as the reference for nuclear waste management. In order to further improve and strengthen their historical cooperation in high temperature waste management, the CEA, R and D organization, and AREVA, Industrial Operator, decided, in September 2010, to create a Joint Vitrification Laboratory within the framework of a strategic partnership. The main objectives of the CEA-AREVA Joint Vitrification Laboratory (LCV) are (i) support AREVA's activities, notably in its La Hague plants and for new projects, (ii) strengthen the CEA's lead as a reference laboratory in the field of waste conditioning. The LCV is mandated to provide strong, innovative solutions through the performance of R and D on processes and materials for vitrification, fusion and incineration, for high, intermediate and low level waste. The activities carried out in the LCV include academic research on containment matrices (formulation, long-term behaviour), and the improvement of current technologies/development of new ones in lab-scale to full-scale pilot facilities, in non-radioactive and radioactive conditions, including modelling and experimental tools. This paper focuses on the programs and policy managed within the LCV, as well as the means employed by the CEA and AREVA to meet common short-,mid- and long-term challenges, from a scientific and industrial point of view. Among other things, we discuss the technical support provided for the La Hague vitrification facilities on hot melter and CCIM technologies, the start-up of new processes (decommissioning effluents, UMo FP) with CCIM, the preparation of future processes by means of an assessment of new technologies and containment matrices (improved glasses, ceramics, etc.), as well as incineration/vitrification for organic and metallic mixed waste or metallic fusion. The close relationship between the R and D teams and industrial operators enables the LCV to propose attractive waste management solutions, with appropriate schedules and optimized development costs, making allowance for R and D constraints, engineering requirements and the industrial environment. (authors)

Piroux, Jean Christophe [AREVA NC Marcoule LCV (France)] [AREVA NC Marcoule LCV (France); Paradis, Luc; Ladirat, Christian [CEA Marcoule LCV (France)] [CEA Marcoule LCV (France); Brueziere, Jerome; Chauvin, Eric [AREVA NC Paris La Defense (France)] [AREVA NC Paris La Defense (France)

2013-07-01

154

Unilateral hyperhydrosis in Pourfour du Petit syndrome  

Microsoft Academic Search

Upper limp hyperhydrosis is an idiopathic disease with bilateral involvement. However, Pourfour du Petit syndrome, the opposite of Horner syndrome, may result in unilateral upper limb hyperhydrosis. It occurs following hyperactivity of the sympathetic cervical chain as a consequence of irritation secondary to trauma. We report herein two cases with Pourfour du Petit syndrome showing unilateral upper limb hyperhydrosis. The

Murat Kara; Erkan Dikmen; Cengiz Akarsu; Ahu Birol

2004-01-01

155

Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA  

PubMed Central

Objective MicroRNA-21 (miR-21) has been shown to be a key regulator of carcinogenesis. There were few reports about the comparison of serum miR-21 with conventional tumor markers. This study aimed to explore the diagnostic value of circulating miR-21 as a tumor marker in breast cancer (BC) and compare it with CA153 and carcinoembryonic antigen (CEA). Methods Circulating miR-16 and miR-21 were amplified and quantitatively detected by real-time PCR in 89 BC patients and 55 healthy controls. The levels of CA153 and CEA were measured through electrochemiluminescence assays. Then the sensitivity in diagnosis of BC was compared among miR-21, CA153 and CEA. Results The level of serum miR-21 was significantly higher in BC patients than controls (P<0.001). The sensitivity and specificity of miR-21 were 87.6% and 87.3%, respectively, whereas the sensitivities of CEA and CA153 were only 22.47% and 15.73%. Conclusions Compared with CEA and CA153, serum miR-21 has a higher sensitivity in diagnosis of BC. Although not correlated with the status of ER, PR and clinical stages, serum miR-21 may be a potential diagnostic indicator for BC, especially for the early stage.

Gao, Jianjian; Xu, Jianjun; Guo, Lijuan; Li, Xuefeng

2013-01-01

156

CEA promoter-regulated oncolytic adenovirus-mediated Hsp70 expression in immune gene therapy for pancreatic cancer.  

PubMed

Gene therapy is an important means for the comprehensive treatment of pancreatic cancer. Challenges associated with gene therapy include control of vector security and effective genetic screening. In this paper, a CEA promoter-regulated oncolytic adenovirus vector was constructed. The reporter gene assay demonstrated that the viral vector was confirmed to have tumor-specific replication features. In vitro cytology studies showed that the CEA promoter regulated the proliferation of the adenovirus vector carrying the Hsp70 gene (AdCEAp-Hsp70), which significantly increased the expression levels of Hsp70 in the CEA-positive pancreatic cancer cells, resulting in an overall reduction in the survival of cancer cells. In the human pancreatic cancer Panc-1 xenograft model in immune deficient nude mice, the CEA promoter-regulated adenovirus AdCEAp-Hsp70 significantly inhibited tumor growth. In the rat pancreatic cancer DSL-6A/C1 xenograft model in rats, the viral proliferation and high expression levels of Hsp70 promoted the interstitial infiltration of CD4+, CD8+ and gamma/delta T cells into tumors, induced host secretion of the cytokines TGF-?, INF-?, and IL-6 and had a dual anti-tumor effects that completely inhibited the growth of pancreatic cancer. The results demonstrated that the oncolytic adenovirus under the control of CEA promoter provides additional assurances regarding the safety and efficiency of cancer gene therapy. This gene therapy model improves anti-cancer efficiency and has broad applications and developmental prospects. PMID:22261331

Xu, Can; Sun, Yunliang; Wang, Yunfeng; Yan, Yan; Shi, Zhengjie; Chen, Lei; Lin, Han; Lü, Shunli; Zhu, Maoling; Su, Changqing; Li, Zhaoshen

2012-06-28

157

Potent and Specific Antitumor Effect for Colorectal Cancer by CEA and Rb Double Regulated Oncolytic Adenovirus Harboring ST13 Gene  

PubMed Central

Cancer Targeting Gene-Viro-Therapy (CTGVT) is constructed by inserting an antitumor gene into an oncolytic virus (OV). It is actually an OV-gene therapy, which has much better antitumor effect than either gene therapy alone or virotherapy alone in our previously published papers. This study is a modification of CTGVT by inserting a colorectal cancer (CRC) specific suppressor gene, ST13, into a CRC specific oncolytic virus, the Ad·CEA·E1A(?24), to construct the Ad·(ST13)·CEA·E1A(?24) for increasing the targeting tropism to colorectal cancer and it was briefly named as CTGVT-CRC. Although many studies on CEA promoter and ST13 gene were reported but no construct has been performed to combine both of them as a new strategy for colorectal cancer (CRC) specific therapy. In addition to the CRC specificity, the antitumor effect of Ad·(ST13)·CEA·E1A(?24) was also excellent and got nearly complete inhibition (not eradication) of CRC xenograft since ST13 was an effective antitumor gene with less toxicity, and a Chinese patent (No. 201110319434.4) was available for this study. Ad·(ST13)·CEA·E1A(?24) caused cell apoptosis through P38 MAPK (i.e. P38) which upregulated CHOP and ATF2 expression. The mitochondrial medicated apoptosis pathway was activated by the increase of caspase 9 and caspase 3 expression.

Wang, Shibing; Wang, Yigang; Zhang, Kangjian; Zheng, Shu; Chu, Liang; Xiao, Lianli; Yu, Yuemei; Zhang, Yue; Liu, Xinyuan

2012-01-01

158

Plasma studies on electron cyclotron resonance light ion source at CEA/Saclay  

NASA Astrophysics Data System (ADS)

By the 90s, the CEA has undertaken to develop the production of intense light ion beams from unconfined ECR plasma. Today, three sources for IPHI, SPIRAL2, and IFMIF projects (respectively, 100 mA of H+, 8 mA of D+, and 140 mA of D+) are installed at CEA/Saclay. In order to improve performances and decrease dimensions of these sources, it is necessary to better understand the mechanisms involved in the production and extraction of particles. As a consequence, theoretical and experimental studies are being carried out. We present a theoretical study based on SOLMAXP, a home-made particle-in-cell code. The aim is to investigate the possibility of reducing the plasma chamber size without loss of beam characteristics. This code has been validated by beam intensity measurements on a permanent magnet based source, producing a proton beam of 30 mA at 40 kV on the test bench BETSI. In order to reduce experimentally the dimensions of plasma chamber, a new source, named ALISES with variable plasma chamber volume, is under assembly.

Nyckees, S.; Delferrière, O.; Duperrier, R.; Harrault, F.; Tuske, O.

2012-02-01

159

Aeroacoustics research in Europe: The CEAS-ASC report on 2010 highlights  

NASA Astrophysics Data System (ADS)

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2010, compiled from information provided to the ASC of the CEAS. At the end of 2010, project X-NOISE EV of the Seventh Framework Programme of the European Commission has been launched as a continuation of the X-Noise series, with objectives of reducing aircraft noise and reaching the goal set by the ACARE 2020 Vision. Some contributions submitted to the editor summarizes selected findings from European projects launched before or concluded in 2010, while other articles cover issues supported by national associations or by industries. Furthermore, a concise summary of the workshop on "Aeroacoustics of High-Speed Aircraft Propellers and Open Rotors" held in Warsaw in October is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

Balázs Nagy, Attila

2011-10-01

160

Aeroacoustics research in Europe: The CEAS-ASC report on 2009 highlights  

NASA Astrophysics Data System (ADS)

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2009, compiled from information provided to the ASC of the CEAS. In April 2009, the Level-2 project OPENAIR of the Seventh Framework Programme of the European Commission has been launched with the goal of delivering a step change in noise reduction, beyond the successful achievements of the predecessor SILENCE(R). Some contributions submitted to the editor summarizes findings from programmes launched before 2009, while other contributions report on activities supported by national associations and industries. Furthermore, a concise summary of the workshop on "Resolving Uncertainties in Airframe Noise Testing and CAA Code Validation" held in Bucharest is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

Casalino, Damiano

2010-10-01

161

High intensity ECR ion source (H+, D+, H-) developments at CEA/Saclay  

NASA Astrophysics Data System (ADS)

Source of light ions with high intensities The (SILHI) source has been producing proton beams since 1996. The first aim is to produce up to 100 mA cw beams at 95 keV for the injector of protons for high intensity demonstrator. This prototype is developed by a CEA/DSM-CNRS/IN2P3 collaboration for applications such as accelerator driven systems for nuclear waste transmutation, production of radioactive ion beams, or secondary particles. To measure installation reliability, continuous 5 day long runs have been performed. In October 1999, a 99.96% availability was achieved with a single short beam off and a 103 H uninterrupted beam. A new extraction system leads to lower beam losses and higher LEBT transparency. SILHI now produces a 95 keV-130 mA total beam with a proton fraction higher than 80%. Up to a 157 mA (247 mA/cm2) total cw beam has been extracted. The new EPICS control system, electromagnetic interference hardened devices and automatic control procedures now allow us to do longer runs. To analyze the reliability of these upgrades, a 4 week test was planned. In the framework of the International Fusion Material Irradiation Facility project CEA participation, 135 mA-95 kV deuteron pulsed beams were produced. Extraction simulations and recent SILHI results are also presented. In addition, a new test bench has been recently developed to analyze H- beam production.

Gobin, R.; Beauvais, P.-Y.; Bogard, D.; Charruau, G.; Delferrière, O.; Menezes, D. De; France, A.; Ferdinand, R.; Gauthier, Y.; Harrault, F.; Jannin, J.-L.; Lagniel, J.-M.; Leroy, P.-A.; Mattéi, P.; Sherman, J.; Sinanna, A.; Ausset, P.; Bousson, S.; Pottin, B.

2002-02-01

162

World heritage site - Bien du Patrimoine Mondial - Kluane/Wrangell-St. Elias/Glacier Bay/Tatshenshini-Alsek  

USGS Publications Warehouse

The four parks depicted on this map make up a single World Heritage Site that covers 24.3 million acres. Together, they comprise the largest internationally protected land-based ecosystem on the planet. The United Nations Educational, Scientific and Cultural Organization (UNESCO) established the World Heritage Program in 1972 for the identification and protection of the world?s irreplaceable natural and cultural resources. World Heritage Sites are important as storehouses of memory and evolution, as anchors for sustainable tourism and community, and as laboratories for the study and understanding of the earth and culture. This World Heritage Site protects the prominent mountain ranges of Kluane, Wrangell, Saint Elias, and Chugach. It includes many of the tallest peaks on the continent, the world's largest non-polar icefield, extensive glaciers, vital watersheds, and expanses of dramatic wilderness. [Les quatre parcs figurant sur cette carte ne constituent qu?un seul site du patrimoine mondial recouvrant plus de 99 millions de km2, ce qui en fait le plus grand ecosysteme terrestre protege par loi internationale. En 1972, L?UNESCO (l?organisation des Nations Unies pour les sciences, l'education et la culture) a etabli le programme du patrimoine mondial afin d?identifier et de proteger les ressources naturelles et culturelles irremplacables de notre plan?te. Si les sites du patrimoine mondial sont si importants c'est parce qu'ils representent a la fois des livres ouverts sur l?histoire de la Terre, le point de depart du tourisme durable et du developpement des collectivites, des laboratoires pour etudier et comprendre la nature et la culture. Ce site du patrimoine mondial assure la protection des chaines de montagnes de Kluane, Wrangell, Saint Elias, et Chugach. On y trouve plusieurs des plus hauts sommets du continent, le plus grand champ de glace non-polaire du monde, d?immenses glaciers, des bassins hydrologiques essentiels, et de la nature sauvage a perte de vue.

Labay, Keith A.; Wilson, Frederic H.

2004-01-01

163

Search for CEA-like molecules in polymorphonuclear leukocytes of non-human primates using monoclonal antibodies.  

PubMed

The monoclonal anti-CEA antibody ZIK-A42-A/C1 which reacts with NCA of human polymorphonuclear leukocytes was found to bind also to polymorphonuclear blood leukocytes of the following non-human primates tested: hamadryas baboon (Papio hamadryas), stump-tailed monkey (Macaca arctoides), pig-tailed monkey (Macaca nemestrina), and rhesus monkey (Macaca mulata). No binding was observed to mononuclear blood leukocytes. It was concluded that non-human primates contain CEA-like substances in their polymorphonuclear leukocytes as humans do and that these substances carry some identical epitopes. PMID:3518651

Jantscheff, P; Indzhiia, L V; Micheel, B

1986-01-01

164

Diffusion des Metaux et Evolution Stellaire  

NASA Astrophysics Data System (ADS)

Nous presentons dans cette these des modeles d'evolution stellaire incorporant la diffusion microscopique de maniere consistante. Pour la premiere fois, on a calcule l'evolution d'etoiles en tenant compte en detail de l'impact des variations d'abondances sur leur structure. Nous utilisons des spectres monochromatiques pour chacun des elements les plus abondants dans un melange solaire pour recalculer l'opacite pour les abondances et les conditions locales dans l'interieur d'une etoile au cours de son evolution. Nos modeles montrent que la diffusion atomique des metaux a un effet important sur les opacites dan les etoiles de plus de 1.3Msolar ou l'abondance du fer et des autres elements du pic du fer varient substantiellement. Ces etoiles, sans rotation ou champ magnetique, sont proches des etoiles de type Fm-Am dans lesquelles on observe une legere surabondance d'elements du pic du fer en plus d'une sous-abondance de calcium, sous-abondance que l'on obtient egalement. Nous obtenons cependant des surabondances depassant un facteur 10 pour les etoiles de plus de 1.4Msolar ce qui suggere qu'il existe un ou plusieurs mecanismes limitant la diffusion microscopique. La surabondance du fer en surface cause une augmentation, qui peut atteindre un facteur sept, de l'opacite a la limite de la zone convective. Ceci cause un accroissement de la temperature effective et de la masse de la zone convective comparativement aux modeles n'incluant que la diffusion de l'helium. Il s'agit la du principal effet de la diffusion sur la structure interne de ces etoiles. La diffusions n'a pas d'influence sur l'evolution de coeur stellaire dans les etoiles significativement plus massives quie le Soleil. Nous avons verife que l'utilisation de modeles consistants avec diffusion n'apporte pas d'amelioration sensible aux modeles solaires. Les forces radiatives calculees a partir des spectres d'OPAL pour les elements du pic du fer representent une fraction importante de la gravite. On obtient des forces de 40% la gravite a la base de la zone convective. Ces forces radiatives sont assez grandes pour avoir un impact significatif sur les variations d'abondance de ces elements. Cet effet est neglige dans les modeles solaires publies. Nos modeles solaires montrent que les donnees du projet OPACITE pour le fer sont trop deficientes dans leur etat actuel pour pouvoir etre utilisees dans des calculs evolutifs. Nous confirmons que la diffusion doit etre prise en compte pour reproduire les donnes helioseismologiques. Nous discutons en detail de la manipulation des donnees monochromatiques. Il en ressort que les donnees d'OPAL sont superieures aux donnees tirees de OP. Les donnees de OP sont utiles pour les forces radiatives dans deux applications. Premierement pour determiner les corrections a apporter aux accelerations radiatives de OPAL pour tenir compte de la redistribution de l'impulsion lors de la photoionisation, puis parce que le sampling de OPAL perd de sa validite a basse temperature et pour les metaux tres peu abondants. Finalement nous avons calcule des modeles d'etoiles de population II de faible metallicite. Nous montrons dans un premier temps que la diffusion des metaux n'a pas d'effet significatif sur l'evolution de ces etoiles. Nous montrons egalement que l'incertitude sur l'age des amas globulaires associe a la diffusion est sous-estimee. Quoique la difference s'amenuise il existe toujours un desaccord avec l'age de l'Univers tel que determine a partir de la loi de Hubble.

Turcotte, Sylvain

165

Les représentations du stress des dirigeants : quelles implications pour la gestion du stress au travail ?  

Microsoft Academic Search

La question du mal-être au travail, que ce soit sous l'angle du stress ou des suicides au travail récemment médiatisés, a brutalement fait irruption dans l'agenda stratégique des dirigeants. Afin d'améliorer la santé des salariés et de promouvoir leur bien-être, il est utile de s'appuyer sur les travaux existants en matière d'interventions de gestion du stress (notamment Brun et al.,

Stéphan Pezé

2010-01-01

166

Effets de l'alteration sur quelques proprietes mecaniques du granite du sidobre (France)  

Microsoft Academic Search

Résumé  Les altérations croissantes dans le granite du Sidobre ont été suivies par divers essais mécaniques: compression uniaxiale,\\u000a concassage et forage. On constate que les variations de la charge de rupture, du module d'Young, du temps de concassage et\\u000a de la vitesse de forage se répartissent en deux domaines distincts. Ces deux domaines sont séparés par un important décrochement\\u000a dont le

J. Baudracco; M. Bel; R. Perami

1982-01-01

167

Big Data solution for CTBT monitoring: CEA-IDC joint global cross correlation project  

NASA Astrophysics Data System (ADS)

Waveform cross-correlation when applied to historical datasets of seismic records provides dramatic improvements in detection, location, and magnitude estimation of natural and manmade seismic events. With correlation techniques, the amplitude threshold of signal detection can be reduced globally by a factor of 2 to 3 relative to currently standard beamforming and STA/LTA detector. The gain in sensitivity corresponds to a body wave magnitude reduction by 0.3 to 0.4 units and doubles the number of events meeting high quality requirements (e.g. detected by three and more seismic stations of the International Monitoring System (IMS). This gain is crucial for seismic monitoring under the Comprehensive Nuclear-Test-Ban Treaty. The International Data Centre (IDC) dataset includes more than 450,000 seismic events, tens of millions of raw detections and continuous seismic data from the primary IMS stations since 2000. This high-quality dataset is a natural candidate for an extensive cross correlation study and the basis of further enhancements in monitoring capabilities. Without this historical dataset recorded by the permanent IMS Seismic Network any improvements would not be feasible. However, due to the mismatch between the volume of data and the performance of the standard Information Technology infrastructure, it becomes impossible to process all the data within tolerable elapsed time. To tackle this problem known as "BigData", the CEA/DASE is part of the French project "DataScale". One objective is to reanalyze 10 years of waveform data from the IMS network with the cross-correlation technique thanks to a dedicated High Performance Computer (HPC) infrastructure operated by the Centre de Calcul Recherche et Technologie (CCRT) at the CEA of Bruyères-le-Châtel. Within 2 years we are planning to enhance detection and phase association algorithms (also using machine learning and automatic classification) and process about 30 terabytes of data provided by the IDC to update the world seismicity map. From the new events and those in the IDC Reviewed Event Bulletin, we will automatically create various sets of master event templates that will be used for the event location globally by the CTBTO and CEA.

Bobrov, Dmitry; Bell, Randy; Brachet, Nicolas; Gaillard, Pierre; Kitov, Ivan; Rozhkov, Mikhail

2014-05-01

168

Improved Duplication Models for Proteome Network Evolution  

Microsoft Academic Search

Protein-protein interaction networks, particularly that of the yeast S. Cerevisiae, have recently been studied extensively. These net- works seem to satisfy the small world property and their (1-hop) degree distribution seems to form a power law. More recently, a number of du- plication based random graph models have been proposed with the aim of emulating the evolution of protein-protein interaction

Gürkan Bebek; Petra Berenbrink; Colin Cooper; Tom Friedetzky; Joseph H. Nadeau; Süleyman Cenk Sahinalp

2005-01-01

169

Science and technology research and development in support to ITER and the Broader Approach at CEA  

NASA Astrophysics Data System (ADS)

In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented. Commissariat à l'Energie Atomique et aux énergies alternatives.

Bécoulet, A.; Hoang, G. T.; Abiteboul, J.; Achard, J.; Alarcon, T.; Alba-Duran, J.; Allegretti, L.; Allfrey, S.; Amiel, S.; Ané, J. M.; Aniel, T.; Antar, G.; Argouarch, A.; Armitano, A.; Arnaud, J.; Arranger, D.; Artaud, J. F.; Audisio, D.; Aumeunier, M.; Autissier, E.; Azcona, L.; Back, A.; Bahat, A.; Bai, X.; Baiocchi, B.; Balaguer, D.; Balme, S.; Balorin, C.; Barana, O.; Barbier, D.; Barbuti, A.; Basiuk, V.; Baulaigue, O.; Bayetti, P.; Baylard, C.; Beaufils, S.; Beaute, A.; Bécoulet, M.; Bej, Z.; Benkadda, S.; Benoit, F.; Berger-By, G.; Bernard, J. M.; Berne, A.; Bertrand, B.; Bertrand, E.; Beyer, P.; Bigand, A.; Bonhomme, G.; Borel, G.; Boron, A.; Bottereau, C.; Bottollier-Curtet, H.; Bouchand, C.; Bouquey, F.; Bourdelle, C.; Bourg, J.; Bourmaud, S.; Brémond, S.; Bribiesca Argomedo, F.; Brieu, M.; Brun, C.; Bruno, V.; Bucalossi, J.; Bufferand, H.; Buravand, Y.; Cai, L.; Cantone, V.; Cantone, B.; Caprin, E.; Cartier-Michaud, T.; Castagliolo, A.; Belo, J.; Catherine-Dumont, V.; Caulier, G.; Chaix, J.; Chantant, M.; Chatelier, M.; Chauvin, D.; Chenevois, J.; Chouli, B.; Christin, L.; Ciazynski, D.; Ciraolo, G.; Clairet, F.; Clapier, R.; Cloez, H.; Coatanea-Gouachet, M.; Colas, L.; Colledani, G.; Commin, L.; Coquillat, P.; Corbel, E.; Corre, Y.; Cottet, J.; Cottier, P.; Courtois, X.; Crest, I.; Dachicourt, R.; Dapena Febrer, M.; Daumas, C.; de Esch, H. P. L.; De Gentile, B.; Dechelle, C.; Decker, J.; Decool, P.; Deghaye, V.; Delaplanche, J.; Delchambre-Demoncheaux, E.; Delpech, L.; Desgranges, C.; Devynck, P.; Dias Pereira Bernardo, J.; Dif-Pradalier, G.; Doceul, L.; Dong, Y.; Douai, D.; Dougnac, H.; Dubuit, N.; Duchateau, J.-L.; Ducobu, L.; Dugue, B.; Dumas, N.; Dumont, R.; Durocher, A.; Durocher, A.; Duthoit, F.; Ekedahl, A.; Elbeze, D.; Escarguel, A.; Escop, J.; Faïsse, F.; Falchetto, G.; Farjon, J.; Faury, M.; Fedorzack, N.; Féjoz, P.; Fenzi, C.; Ferlay, F.; Fiet, P.; Firdaouss, M.; Francisquez, M.; Franel, B.; Frauche, J.; Frauel, Y.; Futtersack, R.; Garbet, X.; Garcia, J.; Gardarein, J.; Gargiulo, L.; Garibaldi, P.; Garin, P.; Garnier, D.; Gauthier, E.; Gaye, O.; Geraud, A.; Gerome, M.; Gervaise, V.; Geynet, M.; Ghendrih, P.; Giacalone, I.; Gibert, S.; Gil, C.; Ginoux, S.; Giovannangelo, L.; Girard, S.; Giruzzi, G.; Goletto, C.; Goncalves, R.; Gonde, R.; Goniche, M.; Goswami, R.; Grand, C.; Grandgirard, V.; Gravil, B.; Grisolia, C.; Gros, G.; Grosman, A.; Guigue, J.; Guilhem, D.; Guillemaut, C.; Guillerminet, B.; Guimaraes Filho, Z.; Guirlet, R.; Gunn, J. P.; Gurcan, O.; Guzman, F.; Hacquin, S.; Hariri, F.; Hasenbeck, F.; Hatchressian, J. C.; Hennequin, P.; Hernandez, C.; Hertout, P.; Heuraux, S.; Hillairet, J.; Honore, C.; Hornung, G.; Houry, M.; Hunstad, I.; Hutter, T.; Huynh, P.; Icard, V.; Imbeaux, F.; Irishkin, M.; Isoardi, L.; Jacquinot, J.; Jacquot, J.; Jiolat, G.; Joanny, M.; Joffrin, E.; Johner, J.; Joubert, P.; Jourd'Heuil, L.; Jouve, M.; Junique, C.; Keller, D.; Klepper, C.; Kogut, D.; Kubi?, M.; Labassé, F.; Lacroix, B.; Lallier, Y.; Lamaison, V.; Lambert, R.; Larroque, S.; Latu, G.; Lausenaz, Y.; Laviron, C.; Le, R.; Le Luyer, A.; Le Niliot, C.; Le Tonqueze, Y.; Lebourg, P.; Lefevre, T.; Leroux, F.; Letellier, L.; Li, Y.; Lipa, M.; Lister, J.; Litaudon, X.; Liu, F.; Loarer, T.; Lombard, G.; Lotte, P.; Lozano, M.; Lucas, J.; Lütjens, H.; Magaud, P.; Maget, P.; Magne, R.; Mahieu, J.-F.; Maini, P.; Malard, P.; Manenc, L.; Marandet, Y.; Marbach, G.; Marechal, J.-L.; Marfisi, L.; Marle, M.; Martin, C.; Martin, V.; Martin, G.; Martinez, A.; Martino, P.; Masset, R.; Mazon, D.; Mellet, N.; Mercadier, L.; Merle, A.; Meshcheriakov, D.; Messina, P.; Meyer, O.; Millon, L.; Missirlian, M.; Moerel, J.; Molina, D.; Mollard, P.; Moncada, V.; Monier-Garbet, P.; Moreau, D.; Moreau, M.; Moreau, P.; Morel, P.; Moriyama, T.; Motassim, Y.; Mougeolle, G.; Moulton, D.; Moureau, G.; Mouyon, D.; Naim Habib, M.; Nardon, E.; Négrier, V.; Nemeth, J.; Nguyen, C.; Nguyen, M.; Nicolas, L.; Nicolas, T.; Nicollet, S.; Nilsson, E.; N'Konga, B.; Noel, F.; Nooman, A.; Norscini, C.; Nouailletas, R.; Oddon, P.; Ohsako, T.; Orain, F.; Ottaviani, M.; Pagano, M.; Palermo, F.; Panayotis, S.; Parrat, H.; Pascal, J.-Y.; Passeron, C.; Pastor, P.; Patterlini, J.; Pavy, K.; Pecquet, A.-L.; Pégourié, B.; Peinturier, C.; Pelletier, T.; Peluso, B.; Petrzilka, V.; Peysson, Y.; Pignoly, E.; Pirola, R.; Pocheau, C.; Poitevin, E.; Poli, V.; Poli, S.; Pompon, F.; Porchy, I.; Portafaix, C.; Preynas, M.; Prochet, P.; Prou, M.; Ratnani, A.; Raulin, D.; Ravenel, N.; Renard, S.; Ricaud, B.; Richou, M.; Ritz, G.; Roche, H.; Roubin, P.; Roux, C.; Ruiz, K.; Sabathier, F.; Sabot, R.; Saille, A.; Saint-Laurent, F.; Sakamoto, R.; Salasca, S.; Salmon, T.; Salmon, T.; Samaille, F.; Sanchez, S.; Santagiustina, A.; Saoutic, B.; Sarazin, Y.; Sardain, P.; Schlosser, J.

2013-10-01

170

Recent progress on minor-actinide-bearing oxide fuel fabrication at CEA Marcoule  

NASA Astrophysics Data System (ADS)

Partitioning and transmutation (P&T) of minor actinides (MA: americium, neptunium and curium) in fast neutron reactors or accelerator-driven systems is a route envisaged to reduce nuclear waste inventory. Over the years, several modes of P&T were proposed, each being based on the use of dedicated fuels such as inert-matrix fuels, MA-bearing MOX or MA-bearing blankets. In this context, progress on the manufacturing of such fuels is a key-challenge in order to render P&T viable at the industrial scale. Here, MA-bearing oxide fuel fabrication and characterization conducted in the CEA Marcoule Atalante facility is reviewed. A particular attention is also given to the research conducted on uranium-americium mixed-oxides fuels, which are now considered the reference fuels for MA transmutation in France.

Lebreton, Florent; Prieur, Damien; Horlait, Denis; Delahaye, Thibaud; Jankowiak, Aurélien; Léorier, Caroline; Jorion, Frédéric; Gavilan, Elisabeth; Desmoulière, François

2013-07-01

171

Results of the CEA/Saclay H electron cyclotron resonance ion source, ECRIN  

NASA Astrophysics Data System (ADS)

A 2.45 GHz electron cyclotron resonance test stand based on a pure volume H- (negative) ion production is actually under development at CEA Saclay. The negative ion source is working in a pulsed mode, 2 ms at 5-10 Hz. The first H- ions have been observed at the beginning of 2002 with a poor efficiency: only a few microamperes were produced. Several changes inside the plasma chamber have increased the production rate of negative ions up to several milliamperes. A biased grid separates the plasma chamber into two regions. In the first part, we produce excited H2 molecules that are necessary for producing in the second zone H- ions by a dissociative attachment process located near the extraction zone. Qualitative and quantitative beam diagnostics allow measuring several beam parameters and analyzing the effect of gas mixing or materials on the H- production rate.

Tuske, O.; Delferrière, O.; Gobin, R.; Harrault, F.; Steiner, T.

2006-03-01

172

Development of high-sensitivity bolometers at CEA: preparing the PACS successors  

NASA Astrophysics Data System (ADS)

The Herschel/PACS photometer is the largest bolometer camera in operation for submillimeter astronomy in space. CEA Saclay and LETI have developed these bolometers using innovative techniques, such as silicon micro-machining, resonant absorption or CMOS multiplexing. For the next generation space missions an improvement in sensitivity by 2 orders of magnitude is required. We are considering different options to reach sensitivities as low as 10-20W/Hz1/2. Based on our PACS experience, we are exploring the possibility to use semiconducting sensors at very low temperature (50 mK or below). The TES option is also considered as well as the possibility to couple antennas with very small thermal sensors. We present here preliminary results of simulations and analysis for these solutions.

Revéret, V.; Rodriguez, L.; Agnèse, P.; Martignac, J.

2009-12-01

173

Status of the Negative Hydrogen Ion Test Stand at CEA Saclay  

NASA Astrophysics Data System (ADS)

At CEA-Saclay, in 2003, the new 2.45 GHz ECR source, based on pure volume H- ion production, showed a dramatic increase of the H- extracted ion beam. In fact, since the rectangular plasma chamber is separated in two different parts by a stainless steel grid, the extracted H- current rose from few ?A to 1.5 mA. Of course the grid position and its potential with respect to the plasma chamber were optimised. Ceramic plates allow increasing the electron density and lead to an improvement of the negative ion production. Plasma characterization by using Langmuir probes and positive charge analysis are also presented. The last results are reported and discussed. This work is part of the High Performance Negative Ion Sources (HPNIS) program and supported by the European Union under contract HPRI-CT-2001-50021.

Gobin, R.; Benmeziane, K.; Delferrière, O.; Ferdinand, R.; Girard, A.; Harrault, F.

2005-04-01

174

BAGHEERA: A new experimental facility at CEA / Valduc for actinides studies under high dynamic loading  

NASA Astrophysics Data System (ADS)

This paper is a technical presentation about a new experimental facility recently developed at CEA/Valduc, BAGHEERA, a French acronym for “Hopkinson And High Speed Experiments Glove Box”. This facility is used since mid-2003 to characterize the physical and mechanical behaviour of actinides under high dynamic loadings. For this purpose, four basic experimental devices are confined inside a single glove box: a 50?mm bore diameter single stage light gas gun, two compression and torsion split Hopkinson bars (SHPB and TSHB respectively) and a Taylor test device (TTD). Design and technical data on the experimental equipment are addressed, with a particular emphasis on the gas gun specific features due to actinide applications.

Roy, G.; Llorca, F.; Lanier, G.; Lamalle, S.; Beaulieu, J.; Antoine, P.; Martinuzzi, P.

2006-08-01

175

Prospective for large All Silicon Bolometer Arrays for Far Infrared and submillimeter astronomy at CEA.  

NASA Astrophysics Data System (ADS)

In May 2009, the ESA Herschel Space Observatory was located at L2 (Sun-Earth) by an Ariane V launcher. One month later, a three-colour picture of M51 was the first image released from the observatory. This image was obtained by the PACS photometer, one of the three instruments aboard Herschel. The PACS photometer detectors are, all silicon bolometer arrays with resistive sensors, developed at CEA. These collectively manufactured detectors featured some new developments: light resonant absorption, very high impedance sensors and time domain multiplexing. Today similar focal planes are used in future submillimeter cameras (2013): PILOT a balloon borne observatory for the ISM polarization measurement, and ArTeMiS at the APEX telescope in Chile. We present also the new developments, on these detectors, to improve sensitivity, to extend wavelength coverage to the millimetre domain, and even to include pixel spectroscopic capabilities.

Rodriguez, Louis; Agnese, Patrick; Reveret, Vincent; Cachard, Vincent; Boulade, Olivier

2012-07-01

176

GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)  

NASA Astrophysics Data System (ADS)

Nuclear waste partitionning and transmutation (P & T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON ( GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

Schapira, J. P.

1999-07-01

177

Science and Technology Research and Development in Support to ITER and the Broader Approach at CEA  

SciTech Connect

In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented.

Becoulet, A. [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance] [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance; Hoang, G T [French Atomic Energy Commission (CEA), Institute for Magnetic Fusion Research (IRFM)] [French Atomic Energy Commission (CEA), Institute for Magnetic Fusion Research (IRFM); Abiteboul, J. [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance] [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance; Achard, J. [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance] [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance; Alarcon, T. [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance] [French Atomic Energy Commission (CEA), Cadarache, St. Paul lez Durance; Klepper, C Christopher [ORNL] [ORNL

2013-01-01

178

Evaluation of the serum markers CEA, NSE, TPS and CYFRA 21.1 in lung cancer.  

PubMed

We investigated the role of tumor markers CEA, NSE, TPS and CYFRA 21.1 in lung cancer diagnosis and staging in 169 patients with histologically confirmed lung cancer (43 SCLC and 126 NSCLC). In SCLC patients NSE and CYFRA 21.1 showed the highest sensitivity and their combination improve significantly the diagnostic sensitivity and accuracy. In NSCLC patients CYFRA 21.1 showed the highest sensitivity and global accuracy and no markers association was as effective as CYFRA 21.1 alone. Based on data from our study it can be concluded that in patients with suspected lung cancer the serum NSE and CYFRA 21.1 assay is a suitable association to confirm the clinical hypothesis. NSE in SCLC and CYFRA 21.1 in NSCLC are useful in the evaluation of disease extent and successive treatment planning. PMID:8551058

Giovanella, L; Ceriani, L; Bandera, M; Beghe, B; Roncari, G

1995-01-01

179

CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999. Pt. 2  

NASA Technical Reports Server (NTRS)

The proceedings of a workshop sponsored by the Confederation of European Aerospace Societies (CEAS), the American Institute of Aeronautics and Astronautics (AIAA), the National Aeronautics and Space Administration (NASA), Washington, D.C., and the Institute for Computer Applications in Science and Engineering (ICASE), Hampton, Virginia, and held in Williamsburg, Virginia June 22-25, 1999 represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft.

Whitlow, Jr., Woodrow (Editor); Todd, Emily N. (Editor)

1999-01-01

180

Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins  

Microsoft Academic Search

The present study was performed to identify tumor cells in lymph nodes from colorectal adenocarcinomas considered free of disease by the classic hematoxylin-eosin stain, based on the detection of the carcinoembryonic antigen (CEA) and cytokeratins in neoplastic epithelial cells. For this purpose, 603 lymph nodes from 46 lesions were stained by the peroxidase-antiperoxidase technique. Tumor cells were detected in 22

Raul Cutait; Venfincio A. F. Alves; Luiz Cfimara Lopes; Daher E. Cutait; José Luiz A. Borges; JÚlio Singer; José Hyppólito da Silva; Fábio S. Goffi

1991-01-01

181

Survey of Natural Irradiation in France: Description and First Results of the Commissariat a l'Energie Atomique (CEA) Program.  

National Technical Information Service (NTIS)

A survey of the population exposure to natural sources of radiation has been undertaken by the CEA. It is carried out at the level of 'administrative subdivisions'; in each subdivision, 400-500 calcium sulfate dosimeters have been exposed during some 6 mo...

J. M. Guezengar A. Bouville C. Madelmont

1980-01-01

182

Learning about Cri du Chat Syndrome  

MedlinePLUS

... this page Chromosomal Abnormalities An NHGRI fact sheet Learning About Cri du Chat Syndrome What is cri ... syndrome have difficulty with language. Half of children learn sufficient verbal skills to communicate. Some individuals learn ...

183

Charles Baudelaire's Fleurs du Mal  

NSDL National Science Digital Library

Charles Baudelaire was an acclaimed poet and translator, and during his life he produced works that explored the urban condition, psychological turmoil, and despondency. He took meticulous care when crafting his poems, and his first work, Les Fleurs Du Mal (The Flowers of Evil) was published in 1857 when he was 36. The work was later praised by Gustave Flaubert and Victor Hugo, but the French government took exception to some of the poems contained in the volume and banned them until 1949. This site provides interested parties with access to the complete contents of the 1857 edition, along with the 1861 edition. The site also contains audio recordings of the poems made by Eva Le Gallienne and Louis Jordan for Caedmon Records. The site is quite a find, and users with a penchant for Baudelaire's works will want to return several times.

184

Evaluation intégrée et modélisation du Changement Climatique  

Microsoft Academic Search

Pour l'essentiel, l'idée de la « modélisation intégrée du Changement Climatique » consiste à réaliser des modèles qui couplent la description des activités humaines déterminant les émissions de gaz à effet de serre avec des modèles climatiques dont l'évolution est dépendante de ces émissions. On rend compte, en retour, des impacts du climat modifié sur l'économie sous forme de dommages

Pierre Matarasso

2003-01-01

185

Le pilotage de la performance par les valeurs à travers une approche systémique : le cas du centre de recherche intégré MIRCen (CEA)  

Microsoft Academic Search

A l'heure des pôles de compétitivité et de la concurrence internationale, le pilotage de la performance est l'une des principales priorités des entreprises. Cette performance n'est plus uniquement l'image de critères économiques, mais intègre également d'autres dimensions : sociale, environnementale, scientifique, humaine, éthique... Ces différentes dimensions peuvent être appelées les valeurs de l'entreprise. Les critères de performance sont quantitatifs ou

Aude Schindler; Aurélie Dudezert

2007-01-01

186

Nipple Discharge of CA15-3, CA125, CEA and TSGF as a New Biomarker Panel for Breast Cancer  

PubMed Central

Breast cancer is the second leading cause of cancer death in women. Serum biomarkers such as cancer antigen 15-3 (CA15-3), cancer antigen 125 (CA125), and carcinoembryonic antigen (CEA) can be used as diagnostic and prognostic factors and can also provide valuable information during follow-up. However, serum protein biomarkers show limited diagnostic sensitivity and specificity in stand-alone assays because their levels reflect tumor burden. To validate whether biomarkers in nipple discharge may serve as novel biomarkers for breast cancer, we composed a panel of potential cancer biomarkers, including CA15-3, CA125, CEA, and malignant tumor-specific growth factor (TSGF), and evaluated their expression in both serum and nipple discharge in order to explore the expression and significance of estrogen receptor (ER), progestrone receptor (PR), epidermal growth factor receptor type 2 (HER2/neu), CA15-3, CA125, CEA, and TSGF expression for their combined predictive value for breast cancer and in judging the prognosis of breast cancer. Univariate analysis revealed that combined detection of CA15-3, CA125, CEA, and TSGF in nipple discharge served as novel biomarkers for the diagnosis and prognosis of breast cancer, but in the multivariate analyses the adverse effects of the four biomarkers combination in nipple discharge positivity on overall survival were lost. Multivariate analysis revealed that the positivity of the combined detection of the four biomarkers in both nipple discharge and serum was significantly higher than that of other detection methods. Thus, the combined detection of these four biomarkers both in serum and nipple discharge was retained as an independent prognostic variable in breast cancer patients. Our results indicate that CA15-3, CA125, CEA, and TSGF in nipple discharge can serve as novel biomarkers in the diagnosis and prognosis of breast cancer.

Wang, Gangping; Qin, Yan; Zhang, Junxi; Zhao, Jinhui; Liang, Yun'ai; Zhang, Zuofeng; Qin, Meihua; Sun, Yanqing

2014-01-01

187

Evolution of operations management: past, present and future  

Microsoft Academic Search

Purpose – This paper seeks to analyze the evolution of shift in the area of operations management (OM) and attempts to anticipate potential developments in the relevant areas of OM. \\u000d\\u000aDesign\\/methodology\\/approach – A hybrid approach is adopted to understand how the field of OM has evolved over time relying on the perspectives of both academics and business practitioners. This evolution

Erkan Bayraktar; M. C. Jothishankar; Ekrem Tatoglu; Teresa Wu

2007-01-01

188

The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP-101.  

PubMed

Carcinoembryonic antigen (CEA) has been shown to increase the metastatic potential of some human colorectal cancer cell lines. To investigate further the mechanisms involved we have produced three clones (6, 8 and 17) from the poorly differentiated human colorectal cancer cell line MIP-101 that have been transfected with the full length cDNA encoding for human carcinoembryonic antigen (CEA). They produce CEA with a mol. wt. of 180000 by Western blotting and secrete it into the culture medium. Clone 6 is a high CEA producer, clones 8 and 17 are intermediate producers. The doubling time for clone 8 was similar to that of the parent cell line while clones 6 and 17 had doubling times nearly twice that of the parent cells. These clones are tumorigenic when injected subcutaneously in nude mice are positive for CEA by immunoperoxidase staining and the mice have elevated blood levels of CEA. Clone 6 formed large aggregates in culture while clone 17 formed smaller aggregates. Clone 8 behaved like the parent cell line with rare cell/cell contact. Clones 6 and 17 also adhered to CEA coated plastic while clone 8, a neo-transfected control and the parent cell line did not. A significant increase in the incidence of hepatic tumors was observed with clone 6 (P < 0.01) and clone 17 (P < 0.02) following intrasplenic injection into nude mice. Immunohistopathology of the hepatic tumors showed strong CEA staining from clones 6 and 17 with weak staining from clone 8. The parent cell line was negative for CEA as were the neo-transfected controls. Of the neo controls none of 10 had liver colonies. Mice injected with clone 6 which developed liver metastasis had the highest plasma levels of CEA (37.3 +/- 8.8 ng/ml). We observed strong CEA staining in Kupffer cells in the normal liver adjacent to the CEA producing tumors. This study provides further evidence for the involvement of CEA in the metastatic process. PMID:7757961

Thomas, P; Gangopadhyay, A; Steele, G; Andrews, C; Nakazato, H; Oikawa, S; Jessup, J M

1995-05-25

189

Marqueurs protéiques circulants et cancer du sein  

Microsoft Academic Search

Circulating proteinic biomarkers are secreted by tumor cells or by their environmental cells and they have a variable specificity. In case of breast cancer, carcino-embryonic antigen (CEA) was for a long time the only circulating biomarker used. Nowadays, the most useful biomarkers measure circulating levels of fragments of MUC1–polymorphic epithelial mucin (MUC1–PEM): cancer antigen (CA) 15.3, mucin-like carcinoma-associated antigen (MCA),

C. Mathelin; C. Koehl; M.-C. Rio

2006-01-01

190

Binding of insecticidal lectin Colocasia esculenta tuber agglutinin (CEA) to midgut receptors of Bemisia tabaci and Lipaphis erysimi provides clues to its insecticidal potential.  

PubMed

The insecticidal potential of Galanthus nivalis agglutinin-related lectins against hemipterans has been experimentally proven. However, the basis behind the toxicity of these lectins against hemipterans remains elusive. The present study elucidates the molecular basis behind insecticidal efficacy of Colocasia esculenta tuber agglutinin (CEA) against Bemisia tabaci and Lipaphis erysimi. Confocal microscopic analyses highlighted the binding of 25 kDa stable homodimeric lectin to insect midgut. Ligand blots followed by LC MS/MS analyses identified binding partners of CEA as vacuolar ATP synthase and sarcoplasmic endoplasmic reticulum type Ca(2+) ATPase from B. tabaci, and ATP synthase, heat shock protein 70 and clathrin heavy chain assembly protein from L. erysimi. Internalization of CEA into hemolymph was confirmed by Western blotting. Glycoprotein nature of the receptors was identified through glycospecific staining. Deglycosylation assay indicated the interaction of CEA with its receptors to be probably glycan mediated. Surface plasmon resonance analysis revealed the interaction kinetics between ATP synthase of B. tabaci with CEA. Pathway prediction study based on Drosophila homologs suggested the interaction of CEA with insect receptors that probably led to disruption of cellular processes causing growth retardation and loss of fecundity of target insects. Thus, the present findings strengthen our current understanding of the entomotoxic potentiality of CEA, which will facilitate its future biotechnological applications. PMID:24753494

Roy, Amit; Gupta, Sumanti; Hess, Daniel; Das, Kali Pada; Das, Sampa

2014-07-01

191

Statistiques du chômage : les écarts se creusent depuis cinq ans  

Microsoft Academic Search

[fre] Statistiques du chômage : les écarts se creusent depuis cinq ans - L'ANPE recense à la fin de l'année 1991 2,8 millions demandeurs d'emploi, mais les chômeurs au sens du Bureau International du Travail (BIT), dénombrés par l'enquête Emploi de l'INSEE ne sont que 2,4 millions. Entre ces deux chiffres qui prennent la mesure du chômage, l'écart se creuse

Olivier Marchand

1991-01-01

192

Le Questionnaire d’évaluation du comportement de l’enfant: version canadienne française du Toddler Behavior Assessment Questionnaire  

Microsoft Academic Search

Cette étude vise à valider le Questionnaire d’évaluation du comportement de l’enfant (QÉCE), une version canadienne française du Toddler Behavior Assessment Questionnaire (TBAQ; Goldsmith, 1996) qui est utilisé afin d’évaluer cinq dimensions du tempérament des enfants âgés de 15 à 36 mois : niveau d’activité, tendance à exprimer du plaisir, crainte sociale, prédisposition à la colère et intérêt\\/attention. Un échantillon

Jean-Pascal Lemelin; George M. Tarabulsy; Marc A. Provost; Manon Fournier; Julie Robitaille; Isabelle Hémond; Réjean Tessier

2007-01-01

193

CEA development of filled bolometer arrays at submillimeter wavelengths A possible application to ground-based telescopes at Dome C  

NASA Astrophysics Data System (ADS)

Accompanying the development of the PACS photometer camera (60 210 ?m) on the Herschel Space Observatory, CEA/SAp and CEA/LETI have developed a new type of filled bolometer arrays. We present a camera using these “CCD-like” detectors for ground-based submillimeter applications. Such an instrument could potentially be operated in all atmospheric windows between 200 and 870 ?m on a submillimetre-wave single-dish telescope at Dome C. A bolometer array could consist of several monolithic units of 16×16 pixels (as an example the blue and red PACS arrays consist of 4×2 and 2×1 units, respectively), providing a full sampling of the focal plane.

Minier, V.; Revéret, V.; Rodriguez, L.; Le Pennec, J.; André, P.; Horeau, B.; Agnèse, P.

194

Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.  

PubMed Central

An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy. Images Figure 1

Yanagie, H.; Tomita, T.; Kobayashi, H.; Fujii, Y.; Takahashi, T.; Hasumi, K.; Nariuchi, H.; Sekiguchi, M.

1991-01-01

195

Light ion source for proton/deuteron production at CEA Saclay for the Spiral2 project  

NASA Astrophysics Data System (ADS)

The production of rare radioactive ion beam (RIB) far from the valley of stability is one of the final purposes of the Spiral2 facility in Caen. The RIB will be produced by impinging a deuteron beam onto a carbon sample to produce a high neutron flux, which will interact with a uranium target. The primary deuteron beam is produced by an ion source based on ECR plasma generation. The deuteron source and the low energy beam transport (LEBT) has been assembled and tested at CEA Saclay. Diagnostics from other laboratories were implemented on the LEBT in order to characterize the deuteron beam produced and compare it to the initial simulations. The ion source has been based on a SILHI-type source, which has demonstrated good performances in pulsed and continuous mode, and also a very good reliability on long term operation. The 5 mA of deuteron beam required at the RFQ entrance is extracted from the plasma source at the energy of 40 kV. After a brief description of the experimental set-up, this article reports on the first beam characterization experiments.

Tuske, O.; Adroit, G.; Delferrière, O.; Denis, J.-F.; Gauthier, Y.; Girardot, P.; Gobin, R.; Harrault, F.; Graehling, P.; Guiho, P.; Hosselet, J.; Maazouzi, C.; Sauce, Y.; Uriot, D.; Vacher, T.; Van Hille, C.

2012-02-01

196

The 400W at 1.8K Test Facility at CEA-Grenoble  

NASA Astrophysics Data System (ADS)

A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

2006-04-01

197

Development of a permanent magnet light ion source at CEA/Saclay  

NASA Astrophysics Data System (ADS)

In France, the Spiral 2 project dedicated to radioactive beam production is based on a 40 MeV continuous wave (cw) deuteron Linac. This installation will allow extending the variety of accelerated particles to very heavy elements. Such beams will open research domains for the GANIL facility. To inject the requested 5 mA deuteron beam into the Spiral 2 Linac, the performance of the high intensity light ion source (SILHI) allowed us to propose such an electron cyclotron resonance source. SILHI, developed at CEA/Saclay, regularly produces high intensity (over 100 mA) proton or deuteron beams through a ? 9 mm aperture. So for this project, the main modifications of the source design concern the permanent magnets which provide the axial magnetic configuration and the ? 3 mm aperture. The source produced its first beam (proton) in 2004. This article will report the beam characterization while the source produced D+ beam with intensity as high as 7.0 mA. Recently, this permanent magnet source has been equipped with the ? 9 mm plasma electrode. So high intensity proton beams reaching more than 100 mA are now extracted from this source.

Gobin, R.; Charruau, G.; Delferrière, O.; de Menezes, D.; Gauthier, Y.; Harrault, F.; Leherissier, P.; Pacquet, J. Y.

2006-03-01

198

BETSI, a new test bench for ion sources optimization at CEA SACLAY  

NASA Astrophysics Data System (ADS)

In the framework of several International HPPA projects (such as IFMIF, IPHI, and Spiral2) the CEA handles the design and the developments of several electron cyclotron resonance (ECR) ion sources. For the IFMIF EVEDA demonstrator, a 140 mA cw extracted deuteron beam will be required for high yield of neutron production. For radioactive ion production in the Spiral2 project, several milliamperes of deuterons will be delivered with a permanent magnet source. The optimization of the beam quality at the entrance of the radio frequency quadropole (RFQ) accelerator system triggered the need of a new test bench for ion source optimization and beam qualification. The BETSI ion source test bench will operate up to 50 kV and ignite cw or pulsed hydrogen plasma with a 2.45 GHz magnetron. Great care has already been taken to design electrostatic optics of the extraction system to minimize the emittance growth. Plasma diagnostics will be inserted in the source chamber and several beam diagnostics (emittance and current measurements, beam species analysis) will also be implemented on the low energy beam line transport (LEBT). These diagnostics allow the simultaneous analysis of the beam quality with the plasma parameters of the source. Regional funding request will also be needed to improve the LEBT for space charge compensation measurements. The design of the present and upgraded test bench will be reported as well as the first extracted beam analysis.

Tuske, O.; Adroit, G.; Delferrière, O.; de Menezes, D.; Gauthier, Y.; Gobin, R.; Harrault, F.

2008-02-01

199

Assessment of a European V-4Cr-4Ti alloy - CEA-J57  

NASA Astrophysics Data System (ADS)

About 30 kg of 7 mm-thick plates (grade CEA-J57) were fabricated to support development of vanadium alloys for applications as structural components in future fast neutron fission reactors. After a stress relieve annealing at 973 K, the material exhibited elongated grains and large Ti-rich precipitates oriented in the rolling direction. After final heat-treatment of 2 h at 1273 K, the microstructure was fully recrystallised with remaining aligned large precipitates. Charpy V-notch and tensile specimens were machined in various directions of stress-relieved and recrystallised plates. The fracture energy and the lateral expansion were determined between 113 K and 598 K. Stress-relieved specimens clearly highlighted an anisotropic behavior with both ductile and brittle features while the recrystallized specimens are all ductile: a DBTT of 113 K is suggested. The fracture mode and morphology were related to the microstructure and especially to the Ti-rich precipitate distribution. Additionally, tensile tests were performed at room temperature and between 873 K and 1223 K. The results were consistent with previous results: after a plateau around 400 MPa, a significant decrease in tensile strength is observed above 1023 K. The fracture surfaces always exhibited ductile fracture mode. The present work suggests the good quality of this vanadium alloy. EN 10045-1:1990: Metallic materials - Charpy impact test - Part 1: Test method. EN 14556:2000: Steel - Charpy V-notch pendulum impact test - Instrumented test method.

Le Flem, Marion; Gentzbittel, Jean-Marie; Wident, Pierre

2013-11-01

200

Cost-Effectiveness Analysis (CEA) of Four Interventions for Adolescents with a Substance Use Disorder  

PubMed Central

Alcohol, tobacco, and illicit drug use among adolescents in the U.S. continues to be a serious public health challenge. A variety of outpatient treatments for adolescent substance use disorders have been developed and evaluated. Although no specific treatment modality is effective in all settings, a number of promising adolescent interventions have emerged. As policy makers try to prioritize which programs to fund with limited public resources, the need for systematic economic evaluations of these programs is critical. The present study attempted a cost-effectiveness analysis (CEA) of four interventions, including family-based, individual, and group cognitive behavioral approaches, for adolescents with a substance use disorder. The results indicated that treatment costs varied substantially across the four interventions. Moreover, family therapy showed significantly better substance use outcome compared to group treatment at the 4-month assessment, but group treatment was similar to the other interventions for substance use outcome at the 7-month assessment and for delinquency outcome at both the 4-month and 7-month assessments. These findings over a relatively short follow-up period suggest that the least expensive intervention (group) was the most cost effective. However, this study encountered numerous data and methodological challenges in trying to supplement a completed clinical trial with an economic evaluation. These challenges are explained and recommendations are proposed to guide future economic evaluations in this area.

French, Michael T.; Zavala, Silvana K.; McCollister, Kathryn E.; Waldron, Holly B.; Turner, Charles W.; Ozechowski, Timothy J.

2008-01-01

201

A Review of 25 Years of Corrosion Studies on HLW Container Materials at the CEA  

SciTech Connect

The Commissariat a l'Energie Atomique (CEA, French Atomic Energy Commission) has been involved in researches on nuclear waste management for more than 25 years. One of the key issues is the prediction of the long term behavior and aging of the High Level Waste (HLW) containers in order to develop concepts that will ensure the confinement of the activity over extremely long periods of time. Preliminary studies were carried out on two concepts, one of a thin 'corrosion resistant' container made of titanium or nickel base alloy, and the other on a thick 'corrosion allowance' container made or carbon steel. The results of these experiments showed that the 'corrosion resistant' concept led to a high uncertainty on the development and propagation rate of localized forms of corrosion, and the concept of geological disposal in an argillaceous host formation of thick waste containers made of carbon steel was chosen as the reference for further studies. This eventually led to the voting of a law relative to nuclear waste management on June 28 2006, which endorses the geological disposal of corrosion allowance containers as the reference solution, while stating than an effort must be kept on the research on actinides transmutation to reduce the time during which a geological disposal facility has to be proven capable to ensure the confinement of the radioactive waste. Studies are still in progress to better assess the corrosion mechanisms relevant to this situation in order to provide reliable models for the long term prediction of the containers corrosion behavior. (author)

Helie, Max [Department of Physical Chemistry, French Atomic Energy Commission, DPC/SCCME, Bat 458, Centre d'Etudes de Saclay, Gif sur Yvette, 91191 (France)

2007-07-01

202

The CEA/Saclay 2.45 GHz Microwave Ion Source for H- Ion Production.  

NASA Astrophysics Data System (ADS)

H- ions have now been observed in currents extracted from the CEA/Saclay ECR proton source. A pulsed, 90 degree dipole magnet has been installed 14.8 cm downstream from an ion beam extraction system designed to operate up to 10 kV. The plasma chamber can be biased by a negative or positive HV power supply and the diagnostics are grounded. The magnetic field is reduced to 200 G at the emission aperture. The measured positive hydrogen ion fractions show a large amount of H2+. A 32 wire profiler has also been installed at the dipole magnet location to analyze the total extracted beam and compare it with calculations. Profile measurements at negative extraction potential indicate an important deflection of the beam when the magnetic filter is installed. To measure a consistent electron to H- ratio, the magnetic filter has been tuned in order to avoid steering the beam off axis. Preliminary results will be reported as well as analysis of the profile. This work is supported by the European Commission under contract ndeg: HPRI-CT-2001-50021.

Gobin, R.; Benmeziane, K.; Delferriere, O.; Ferdinand, R.; Harrault, F.; Sherman, J. D.

2002-11-01

203

Influence du chrome et du niobium sur l'équilibre ?-? dans les aluminiures de titane  

NASA Astrophysics Data System (ADS)

L’influence du chrome et du niobium sur les transformations et équilibres de phases des aluminiures de titane dans le domaine biphasé a/g est étudiée par analyse thermique différentielle, dilatomètrie, et métallographie quantitative après traitements thermiques suivis de trempe. Les compositions et les taux de phases à l’équilibre sont déterminés pour différentes températures du domaine biphasé a/g. Les résultats sont comparés aux calculs thermodynamiques réalisés à l’aide d’une banque de données relative aux intermétalliques de base Ti-Al.

Daloz, D.; Hazotte, A.; Lacaze, J.; Charpentier, M.

2004-12-01

204

Epithelial markers in pancreatic carcinoma: immunoperoxidase localisation of DD9, CEA, EMA and CAM 5.2  

Microsoft Academic Search

Paraffin wax embedded, formalin fixed sections of 22 adenocarcinomas of the exocrine pancreas were stained with four mouse monoclonal antibodies: DD9-E7, an antibody raised against a human pancreatic tumour xenograft; carcino-embryonic antigen (CEA); epithelial membrane antigen (EMA); and cytokeratin (CAM 5.2). An indirect immunoperoxidase technique without enzyme pre-digestion and an affinity-purified sheep anti-mouse peroxidase conjugate were used. All of the

E Heyderman; S E Larkin; P J ODonnell; A M Haines; P J Warren; A G Grant

1990-01-01

205

Metastasizing neuroendocrine carcinoma of the larynx with calcitonin and somatostatin secretion and CEA production, resembling medullary thyroid carcinoma  

Microsoft Academic Search

Summary A 55-year-old man presented with a metastasizing moderately differentiated neuroendocrine carcinoma of the larynx (atypical carcinoid). Immunocytochemical demonstration of neuroendocrine markers (neuron-specific enolase and chromogranin-A) and presence of membrane-bound neurosecretory granules in the cells established the neuroendocrine nature of the tumour. In addition, the tumour was found to produce calcitonin, somatostatin and carcino-embryonic antigen (CEA). Calcitonin and somatostatin were

G. Smets; F. Warson; M.-F. Dehou; G. Storme; R. Sacré; S. Van Belle; G. Somers; W. Gepts; G. Klöppel

1990-01-01

206

Application of the New Decommissioning Regulation to the Nuclear Licensed Facilities (NLF) at Fontenay-aux-Roses's Nuclear Center (CEA)  

Microsoft Academic Search

This abstract describes the application of the new decommissioning regulation on all Nuclear Licensed Facilities (NLF is to say INB in French) at Fontenay-aux-Roses's Center (CEA\\/FAR). The decommissioning process has been applied in six buildings which are out of the new nuclear perimeter proposed (buildings no 7, no 40, no 94, no 39, no 52\\/1 and no 32) and three

Josiane Sauret; Laurence Piketty; Michel Jeanjacques

2008-01-01

207

CEA and AREVA R&D on HTR fuel fabrication and presentation of the CAPRI experimental manufacturing line  

Microsoft Academic Search

In the framework of the French V\\/HTR fuel development and qualification program, the Commissariat à l’Energie Atomique (CEA) and AREVA are conducting R&D projects covering the mastering of UO2 coated particle and fuel compact fabrication technology. To fulfill this task, a review of past knowledge, of existing technologies and a preliminary laboratory-scale work program have been conducted with the aim

François Charollais; Sophie Fonquernie; Christophe Perrais; Marc Perez; Olivier Dugne; François Cellier; Gérard Harbonnier; Marie-Pierre Vitali

2006-01-01

208

Significance of K- ras mutation and CEA level in pancreatic juice in the diagnosis of pancreatic cancer  

Microsoft Academic Search

:   The early diagnosis of pancreatic carcinoma is essential for increasing patient survival rates. In this study, 52 patients\\u000a with suspected pancreatic diseases were examined to investigate the value of K-ras codon 12 point mutation, levels of carcinoembryonic antigen (CEA) and carbohydrate antigen (CA19-9), and cytology of pancreatic\\u000a juice in the diagnosis of pancreatic carcinoma. Pancreatic juice was taken without

Noriaki Futakawa; Wataru Kimura; Seiichi Yamagata; Bin Zhao; Han Ilsoo; Tomomi Inoue; Naohiro Sata; Yoneei Kawaguchi; Yoshiro Kubota; Tetsuichiro Muto

2000-01-01

209

Means of Examination and Evaluation of Fuel Assembly for Water Cooled Power Reactors in the Nuclear Research Center at Saclay (CEA).  

National Technical Information Service (NTIS)

Description is presented of the equipment of two laboratories at Saclay (CEA) concerned with destructive and nondestructive experiences on spent fuels from pressurized water reactors in France. Study of fuel assemblies in fuel storage pools, study of fuel...

G. Colomez, G. Farny, H. Vidal, M. Robin, J. C. Van Craeynest

1984-01-01

210

Inhibition of tumour growth by marimastat in a human xenograft model of gastric cancer: relationship with levels of circulating CEA.  

PubMed

Inhibition of matrix metalloproteinases (MMPs) is an attractive approach to adjuvant therapy in the treatment of cancer. Marimastat is the first orally administered, synthetic MMP inhibitor to be evaluated, in this capacity, in the clinic. Measurement of the rate of change of circulating tumour antigens was used for evaluating biological activity and defining optimum dosage in the early clinical trials of marimastat. Although tumour antigen levels have been used in the clinical management of cancer for many years, they have not been validated as markers of disease progression. In order to investigate the relationship between the effects of marimastat on tumour growth and circulating tumour antigen levels, mice bearing the human gastric tumour, MGLVA1, were treated with marimastat. The MMP inhibitor exerted a significant therapeutic effect, reducing tumour growth rate by 48% (P = 0.0005), and increasing median survival from 19 to 30 days (P = 0.0001). In addition, carcinoembryonic antigen (CEA) levels were measured in serum samples from animals sacrificed at regular intervals, and correlated with excised tumour weight. It was shown that the natural log of the CEA concentration was linearly related to the natural log of the tumour weight and that treatment was not a significant factor in this relationship (P = 0.7). In conclusion, circulating CEA levels were not directly affected by marimastat, but did reflect tumour size. These results support the use of cancer antigens as markers of biological activity in early phase trials of non-cytotoxic anticancer agents. PMID:10487607

Watson, S A; Morris, T M; Collins, H M; Bawden, L J; Hawkins, K; Bone, E A

1999-09-01

211

Inhibition of tumour growth by marimastat in a human xenograft model of gastric cancer: relationship with levels of circulating CEA  

PubMed Central

Inhibition of matrix metalloproteinases (MMPs) is an attractive approach to adjuvant therapy in the treatment of cancer. Marimastat is the first orally administered, synthetic MMP inhibitor to be evaluated, in this capacity, in the clinic. Measurement of the rate of change of circulating tumour antigens was used for evaluating biological activity and defining optimum dosage in the early clinical trials of marimastat. Although tumour antigen levels have been used in the clinical management of cancer for many years, they have not been validated as markers of disease progression. In order to investigate the relationship between the effects of marimastat on tumour growth and circulating tumour antigen levels, mice bearing the human gastric tumour, MGLVA1, were treated with marimastat. The MMP inhibitor exerted a significant therapeutic effect, reducing tumour growth rate by 48% (P = 0.0005), and increasing median survival from 19 to 30 days (P = 0.0001). In addition, carcinoembryonic antigen (CEA) levels were measured in serum samples from animals sacrificed at regular intervals, and correlated with excised tumour weight. It was shown that the natural log of the CEA concentration was linearly related to the natural log of the tumour weight and that treatment was not a significant factor in this relationship (P = 0.7). In conclusion, circulating CEA levels were not directly affected by marimastat, but did reflect tumour size. These results support the use of cancer antigens as markers of biological activity in early phase trials of non-cytotoxic anticancer agents. © 1999 Cancer Research Campaign

Watson, S A; Morris, T M; Collins, H M; Bawden, L J; Hawkins, K; Bone, E A

1999-01-01

212

Ultralow-Dark-Current CdHgTe FPAs in the SWIR Range at CEA and Sofradir  

NASA Astrophysics Data System (ADS)

We report the first results of work carried out at CEA and Sofradir to build ultralow-dark-current focal-plane arrays (FPAs) in the short-wave infrared range (SWIR) for space applications. These FPAs are designed to detect very low flux in the 2- ?m wavelength range. To this end, Sofradir has designed a source follower per detector read-out circuit (ROIC, 384 × 288, 15 ?m pitch). This ROIC has been hybridized on different HgCdTe diode configurations processed at CEA-LETI, and low-flux characterizations have been carried out at CEA-IRFU at low temperature (from 60 K to 160 K). Both ion-implanted p/ n and n/ p diodes have been evaluated. The metallurgical nature of the absorbing layer has also been examined, and both molecular-beam epitaxy (MBE) and liquid-phase epitaxy (LPE) have been applied. Dark-current measurements are discussed in comparison with previous results from the literature. State-of-the-art dark currents are recorded for temperatures higher than 120 K. At temperatures lower than 100 K, the decrease in dark current flattens out for both technologies. In this region, currents between 0.4 e-/s/pixel and 0.06 e-/s/pixel are reported.

Gravrand, O.; Mollard, L.; Boulade, O.; Moreau, V.; Sanson, E.; Destefanis, G.

2012-10-01

213

Predictive Role of CEA and CYFRA 21-1 in Patients with Advanced-stage NSCLC Treated with Erlotinib.  

PubMed

Background: Tumor biomarkers are used for predicting therapy effect and prognosis of patients with non-small cell lung cancer (NSCLC). We focused on their potential role in prediction of the efficacy of erlotinib. Patients and Methods: In a total of 144 patients with advanced-stage (IIIB or IV) NSCLC treated with erlotinib, pre-treatment levels of soluble carcinoembryonic antigen (CEA) and cytokeratin markers in serum were measured. Results: The median progression-free and overall survival for patients with a high level of carcinoembryonic antigen (CEA) was 1.9 and 8.6 vs. 2.9 and 16.1 months for patients with low CEA (p=0.046 and p=0.116). The respective medians for patients with a high level of cytokeratin-19 fragment were 1.9 and 6.1 vs. 3.4 and 23.8 months for patients with the low cytokeratin-19 fragment (p<0.001 and p<0.001). Conclusion: High pre-treatment serum levels of one or both biomarkers are associated with poor outcome of patients with NSCLC treated with erlotinib. PMID:24922695

Fiala, Ondrej; Pesek, Milos; Finek, Jindrich; Benesova, Lucie; Minarik, Marek; Bortlicek, Zbynek; Topolcan, Ondrej

2014-06-01

214

Design of potent, non-toxic anticancer peptides based on the structure of the antimicrobial peptide, temporin-1CEa.  

PubMed

Recent advances in the search for novel anticancer agents have indicated that the positively charged antimicrobial peptides have emerged as promising agents offering several advantages over the conventional anticancer drugs. As a naturally occurring, cationic, ?-helical antimicrobial peptide, temproin-1CEa has been proved to exhibit a potent anticancer effect and a moderate hemolytic activity. In order to reduce the hemolytic activity of temporin-1CEa and improve its anticancer potency towards a range of human breast cancer cells, in the present study, six analogs of temporin-1CEa were rationally designed and synthesized. The amphipathicity levels and ?-helical structural patterns of peptides were reserved, while their cationic property and hydrophobicity were changed. The results of MTT and hemolysis assay indicated that the analog peptides displayed an improved anticancer activity and showed an overall optimized therapeutic index. The hydrophobicity of peptides was positively correlated with their hemolytic and antitumor activities. Moreover, the data suggest a strategy of increasing the cationicity while maintaining the moderate hydrophobicity of naturally occurring amphipathic ?-helical peptides to generate analogs with improved cytotoxicity against tumor cells but decreased activity against non-neoplastic cells such as human erythrocytes. This work highlights the potential for rational design and synthesis of improved antimicrobial peptides that have the capability to be used therapeutically for treatment of cancers. PMID:23609760

Yang, Qing-Zhu; Wang, Che; Lang, Lei; Zhou, Yang; Wang, He; Shang, De-Jing

2013-11-01

215

Traumatisme du testicule chez l’enfant  

Microsoft Academic Search

Résumé\\u000a Introduction  Les traumatismes du testicule sont rares chez l’enfant, et la littérature est très pauvre sur ce sujet. Le but était de les\\u000a analyser à partir d’une étude multicentrique rétrospective.\\u000a \\u000a \\u000a \\u000a \\u000a Matériel et méthodes  Un questionnaire sur les traumatismes du testicule survenus entre 2000 et 2009 a été envoyé dans les différents centres de\\u000a chirurgie pédiatrique français. L’analyse a été effectuée à

F. Lardellier; F. Varlet; M. François; G. Audry; P. Buisson; R. Dubois; P. Galinier; S. Geiss; D. Gorduza; N. Kalfa; I. Lacreuse; M.-D. Leclair; T. Merrot; A. Paye-Jaouen; P. Ravasse; E. Sapin; Y. Teklali; J.-S. Valla; N. Diraduryan; E. Guye; M. Lopez

2010-01-01

216

Prognostic value of combination of Cyfra 21-1, CEA and NSE in patients with advanced non-small cell lung cancer  

Microsoft Academic Search

Objective: To assess the value of Cyfra 21-1, carcino-embryonic antigen (CEA) and neuron-specific enolase (NSE) combined, all three together as prognostic factors in advanced stage non-small cell lung cancer (NSCLC) patients.Patients and methods: Serum samples from untreated NSCLC patients were prospectively collected. All assays were performed using commercial kits blind to clinical information. Serum levels of CEA, NSE and Cyfra

Fabrice Barlési; Céline Gimenez; Jean-Philippe Torre; Christophe Doddoli; Julien Mancini; Laurent Greillier; François Roux; Jean-Pierre Kleisbauer

2004-01-01

217

16. FDG-PET in the Detection of Recurrence in Colorectal Cancer Based on Rising CEA Level. Experience in 72 Patients  

Microsoft Academic Search

Purpose: A rising CEA level after the resection of colorectal cancer is an early indicator of tumour recurrence. However, conventional imaging techniques have limited sensitivity for detecting recurrent disease in such patients. Our group has evaluated the role of Positron Emission Tomography with 18F-Fluorodeoxiglucose (FDG-PET) in this clinical situation.Material and Methods: Seventy-two patients with abnormal CEA levels and normal results

A Maldonado; F Sancho; J Cerdan; A Lozano; N Mohedano; J Jiménez; F Moya; M Zomeño

2000-01-01

218

Understanding Evolution  

NSDL National Science Digital Library

This site provides access to basic and advanced online resources for teaching the science and history of evolutionary biology. The resources are organized by topic: the mechanisms of evolution; the relevance of evolutionary theory to everyday life; lines of scientific evidence; and the history of ideas, research, and contributors in the study of evolution. For teachers, there are searchable databases of lesson plans, activities, and conceptual frameworks on the history of life, evidence for evolution, mechanisms of evolution, and the nature of science. Other materials include links to news items and highlighted features on specific evolution topics.

2004-02-06

219

Significance of CEA and CA19-9 Combination as a Prognostic Indicator and for Recurrence Monitoring in Patients with Stage II Colorectal Cancer.  

PubMed

Background: The purpose of this study was to evaluate the significance of the combination of the carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA19-9) levels as a prognostic indicator and for monitoring for recurrence and metastasis after potentially curative surgery for patients with stage II colorectal cancer. Patients and Methods: A total of 238 patients with stage II colorectal cancer who underwent potentially curative surgery were enrolled in the study. A high CEA level was defined as a level exceeding 5 ng/ml and a high CA19-9 level was defined as a level exceeding 37 U/ml. Results: Out of these 238 patients, 92 (38.7%) patients had high CEA levels, 23 (9.7%) patients had high CA19-9 levels and 15 (6.3%) patients had both high CEA and CA19-9 levels. The disease-free and overall survival rates were significantly worse in patients with both a high CEA level and high CA19-9 level. Tumor marker(s) elevated before the operation tended to be elevated again at the time of relapse. Conclusion: The combination of preoperative CEA and CA19-9 levels was useful for predicting the prognosis and for monitoring recurrence and metastasis after potentially curative surgery in patents with stage II colorectal cancer. PMID:24982398

Shibutani, Masatsune; Maeda, Kiyoshi; Nagahara, Hisashi; Ohtani, Hiroshi; Sakurai, Katsunobu; Toyokawa, Takahiro; Kubo, Naoshi; Tanaka, Hiroaki; Muguruma, Kazuya; Ohira, Masaichi; Hirakawa, Kosei

2014-07-01

220

New trends in ?-ray imaging with CdZnTe/CdTe at CEA-Leti  

NASA Astrophysics Data System (ADS)

Increasing interest in CdTe/CZT for ?-ray imaging has marked the last 10 years with progress in crystal growth, device technology, integrated electronics and signal processing. The purpose of this paper is to present recent advances in these four fields at CEA-LETI. A new method to grow very large dimension CZT up to 300 mm in diameter is presented. MS-contact process control allows design of very small electrodes (100 ?m pitch) and results on long-term stability are presented. The development of low-noise front-end integrated electronics and new interconnects technologies have made "pixel detectors" feasible. Significant effort has been focused on reaching high-energy resolution as well as high detection efficiency. The combination of signal processing such as bi-parametric (BP) approaches and electrode design presents an interest in charge loss compensation for a large range of ?? products, tailing reduction due to geometric effect and depth of interaction information. New digital approaches may give drastic advantages to push the limit of spectrometric performance. In the field of ?-ray application, single-channel device for per-operative probes and small 2-D imager for molecular imaging are the most promising ones. By using a tailored "mixed" electrode (small anode and capacitive grid Frich effect) and a BP correction, an energy resolution of 1% at 662 keV has been demonstrated with CZT based 8×8×15 mm 3 detector. New results of 3-D CZT detectors for ?PET imaging are presented with a measured coincidence time of 2.6 ns FWHM and an expected spatial resolution of 1 mm FWHM.

Verger, Loïck; Gros d'Aillon, Eric; Monnet, Olivier; Montémont, Guillaume; Pelliciari, Bernard

2007-02-01

221

La Carte du Ciel vue de Potsdam  

NASA Astrophysics Data System (ADS)

Ce chapitre s'attache à retracer les aléas de la Carte du Ciel depuis l'Observatoire de Potsdam. Le cas de cet établissement sert de point de comparaison avec les observatoires français, en particulier en ce qui concerne l'organisation du travail au sein de l'Observatoire et le problème de la répartition des ressources humaines et instrumentales dans la poursuite de ce projet de longue haleine. On remarque notamment que si les astronomes allemands, héritiers d'une tradition d'excellence en astrométrie stellaire, se devaient de prendre part à la "Photographische Himmelskarte", ce ne sont pas les observatoires d'astronomie classique mais le nouvel observatoire d'astrophysique de Potsdam qui entreprendra cette tâche. Les études effectuées dans ce cadre sur la photographie stellaire et surtout la photométrie photographique seront ainsi considérées comme des contributions à la jeune science astrophysique - du moins jusqu'à ce que la Carte du Ciel entre en concurrence dans l'Observatoire avec les projets de catalogues de spectres stellaires et de mesure des vitesses radiales.

Bigg, C.

2008-06-01

222

The Du Pont OZ Creative Thinking Network.  

ERIC Educational Resources Information Center

The OZ Creative Thinking Network is a volunteer group of Du Pont Corporation employees devoted to educating themselves and others concerning creativity and innovation. This network, organized in 1986, has a current membership of over 600 employees and has produced a book that couples essays expressing concepts in creativity and innovation with…

Tanner, David

1994-01-01

223

Sign Communication in Cri du Chat Syndrome  

ERIC Educational Resources Information Center

This paper presents findings from a study on the use of sign supported Norwegian (SSN) in two individuals with Cri du chat syndrome (CCS). The study gives a first account of some selected aspects of production and intelligibility of SSN in CCS. Possible deviance in manual parameters, in particular inter- and/or intra-subject variation in the use…

Erlenkamp, Sonja; Kristoffersen, Kristian Emil

2010-01-01

224

Khan Du II--A Series.  

National Technical Information Service (NTIS)

The videos present Khan du, a magical wizard, in different situations, to show handicapped children that they can do many things if they develop a positive attitude. The series combines elements of fantasy, real-life situations, and everyday people to giv...

1994-01-01

225

Prairie du Chien: A Historical Study.  

National Technical Information Service (NTIS)

A literature and record search for locations of prehistoric and historic sites in the Prairie du Chien area was undertaken by the Wisconsin State Historical Society. A search was made to assess the cultural resources present on St. Friole Island and the a...

E. S. Oerichbauer J. E. Freeman

1976-01-01

226

Structure crustale et anomalies du champ de gravite dans l'est du Canada  

NASA Astrophysics Data System (ADS)

Cette these presente les resultats d'etudes gravimetriques menees dans le Bouclier canadien. Les mesures du champ de gravite recoltees le long et a proximite de divers transects Lithoprobe y sont interpretees. Chacun des chapitres de cette these est un article publie ou soumis. Le premier article presente l'interpretation gravimetrique le long de la ligne sismique 52 de Lithoprobe, dans la province de Grenville. A l'echelle regionale, la modelisation de l'anomalie de Bouguer invoque un amincissement crustal au sud du front de Grenville sous le terrane allochtone du reservoir Cabonga. Cet amincissement, localise au niveau de la croute inferieure, peut etre associe a une extension post-orogenique. Le modele gravimetrique a aussi permis de mettre en evidence des caracteristiques majeures non revelees par les donnees sismiques, telle que la zone de contact subverticale entre les terranes du reservoir de Cabonga et du reservoir Dozois. La rampe de Baskatong representerait une discontinuite majeure le long de laquelle, les terranes proterozoiques furent accretes. Par ailleurs, un modele de l'anomalie residuelle, dans la partie nord du profil, met en evidence trois corps gabbroiques peu profonds. Le second article presente des modeles crustaux du nord de la province du Superieur a la lumiere de nouvelles donnees de gravite recoltees le long d'un transect traversant les sous-provinces de Nemiscau et La Grande. L'interpretation de l'anomalie de Bouguer pour le nord de l'Abitibi et l'Opatica, invoque un epaississement crustal. Pour les sous-provinces de Nemiscau et La Grande, l'interpretation gravimetrique invoque une densite de la croute superieure plus elevee qu'en Abitibi et en Opatica. Un leger epaississement crustal est observe dans la sous-province de La Grande. Des sequences supracrustales mafiques sont aussi mises en evidence a l'extremite nord du profil dans la sous-province de La Grande. La signature gravimetrique associee a la variation laterale de densite et les evidences de terrain indiquent un pendage vers le nord des principales frontieres tectoniques. Le troisieme chapitre fait l'objet d'une etude du champ de pesanteur au dessus de la region de la baie d'Ungava a partir de donnees satellite et de nouvelles donnees recoltees le long de la cote sud de la baie. Un leve gravimetrique partant de la baie aux Feuilles, dans la province du Superieur, traversant l'Orogene du Nouveau Quebec (ONQ), et finissant pres de la riviere George dans le craton de Rae, a ete realise. L'interpretation des donnees acquises a permis de fournir des modeles de densite. Ces modeles mettent en evidence un epaississement crustal sous l'ONQ et un amincissement sous le terrane de Kuujjuaq, a l'est de l'orogene. Alors que plus a l'est, dans le craton de Rae, une anomalie negative de quelques dix milligals est correlee avec les extensions vers le nord de la zone de cisaillement de la riviere George (ZCRG) et du batholite de De Pas. L'orientation des structures sur les modeles de gravite suggere un chevauchement du craton de Rae au dessus de l'ONQ. (Abstract shortened by UMI.)

Telmat, Hamid

227

Combination of L-3-phosphoserine phosphatase and CEA using real-time RT-PCR improves accuracy in detection of peritoneal micrometastasis of gastric cancer.  

PubMed

Peritoneal metastasis is the most frequent form of recurrence for advanced gastric cancer. We previously performed a global analysis of the gene expression of gastric cancer cell lines established from peritoneal metastasis with cDNA microarray. One of the up-regulated genes is L-3-phosphoserine phosphatase (L3-PP). We have examined its potential as a novel marker for the detection of peritoneal micrometastasis of gastric cancer. L3-PP mRNA in peritoneal wash from 88 gastric cancer patients was quantified for comparison of carcinoembryonic antigen (CEA) mRNA by means of real-time RT-PCR with a fluorescently-labeled probe to predict peritoneal recurrence. The quantity of L3-PP and CEA correlated with wall penetration. The cut-off value was set at the upper limit of the quantitative value of T1 cases (tumor invades within submucosa) and those above the cut-off value constituted the micrometastasis (MM+) group; eight out of 14 cases with peritoneal dissemination were MM+ L3-PP (57.1% sensitivity) and two out of 57 T1 and T2 cases were MM+ (93% specificity). For two out of 14 cases of peritoneal dissemination only L3-PP could detect micrometastasis of gastric cancer, indicating that L3-PP is superior to CEA especially in poorly-differentiated adenocarcinoma. The combination of CEA and L3-PP improved the accuracy of diagnosis up to 85.7%. Consequently, free cancer cells that cannot be detected by CEA mRNA could be detected using L3-PP mRNA. CEA alone was not sufficient, but L3-PP and CEA in combination can attain a higher accuracy of detection. PMID:15154633

Shimomura, Katsumi; Sakakura, Chouhei; Takemura, Manabu; Takagi, Tsuyoshi; Fukuda, Kenichiro; Kin, Shuichi; Nakase, Yuen; Miyagawa, Kouji; Ohgaki, Masaharu; Fujiyama, Junshin; Fujita, Yoshifumi; Nakanishi, Masayoshi; Hagiwara, Akeo; Shirane, Masatomo; Okazaki, Yasushi; Hayashizaki, Yoshihide; Yamagishi, Hisakazu

2004-01-01

228

Evolution Lessons  

NSDL National Science Digital Library

This collection of lessons from the Evolution and the Nature of Science Institute (ENSI) focus on evolution. Each title is an active link to the named activity. The site also contains links to synopses for all of the lessons and a statement on the appropriate grade level for the lessons.

229

FTS evolution  

NASA Technical Reports Server (NTRS)

Viewgraphs on flight telerobotic servicer evolution are presented. Topics covered include: paths for FTS evolution; frequently performed actions; primary task states; EPS radiator panel installation; generic task definitions; path planning; non-contact alignment; contact planning and control; and human operator interface.

Provost, David E.

1990-01-01

230

Stellar Evolution  

NSDL National Science Digital Library

This site discusses hydrostatic balance, radiation pressure, and gravity and how these things affect the evolution of a star based on its mass. There are three sections that talk about the mass criteria, lifetime, and evolution on the H-R diagram of red dwarfs, mid mass stars, and high mass stars. This site ends with a short quiz.

Miller, Kristen; Miller, Scott

2010-05-25

231

Stellar Evolution  

NSDL National Science Digital Library

This Chandra X-Ray Observatory page links to several activities and articles on stellar evolution. It includes an interactive Flash activity featuring simulations of different-mass stars evolving and a detailed "story" of stellar evolution for the interested reader, available in PDF and HTML formats.

2010-05-28

232

Major Upgrade of the Reactor Dosimetry Interpretation Methodology Used at the CEA General Principle  

NASA Astrophysics Data System (ADS)

One of the main objectives of reactor dosimetry is the determination of the physical parameters characterizing the neutron field in which test samples are irradiated. These characteristics, from neutron spectrum to reaction rates characterization are used in experimental reactors to carry out the follow-up of the irradiation and to qualify the neutron calculation used to model the experiment. In power reactors these characteristics are used for the follow-up of the predicted damages to vessel and interns. Neutron parameters are derived from the dosimeter's activities which have suitable reactions (response functions and radioactive emissions). Then, the activities are analyzed using nuclear data, neutron computation results and data characterizing the conditions of irradiation (temporal and technological data, changes of location, etc.). The current CEA interpretation process applied for industrial power reactor interpretation process presents limitations coming mainly from the calculational tools and the nuclear data knowledge available at the time this method was developed in the mid 90's. However nowadays due to, first the improvement of the neutron calculational tools, for example, a full 3D Monte Carlo reactor modeling providing reaction in a point wise format is now possible in a reasonable time, and second, recent releases of the updated international nuclear data libraries, JEFF3.1, ENDF/B-VII for transport calculation and IRDF2002 and EAF2007 for dosimetry libraries, we have been engaged in a deep renewal of the reactor dosimetry interpretation process. The mains goals of this works are to improve the modeling of the experiment and the neutron parameters calculation for each phase of interest. In addition, uncertainties associated to the derived metrics are quantified in a rigorous way using simulation methods designed to cope with the high non-linearity of the process. After a detailed presentation of the current interpretation process and its limitations, this paper lists the main improvements of the neutron calculation codes and of the international nuclear data libraries. The principle of the new interpretation process is then detailed and a derivation process for the associated uncertainties is exposed. The paper finally analyzes the improvements expected from the refined process.

Destouches, C.; Gregoire, G.; Beretz, D.; Bourganel, S.; Chiron, M.

2009-08-01

233

HgCdTe APD- focal plane array development at CEA Leti-Minatec  

NASA Astrophysics Data System (ADS)

We report the latest developments of MW HgCdTe electron initiated avalanche photo-diodes (e-APDs) focal plane arrays (FPAs) at CEA-LETI. The MW e-APD FPAs are developed in view of ultra-sensitive high dynamic range passive starring arrays, active 2D/3D and dual-mode passive-active imaging, which is why both the passive imaging performance and the gain characteristics of the APDs are of interest. A passive mode responsivity operability of 99.9% was measured in LPE and MBE e-APDs FPAs associated with an average NETD=12mK, demonstrating that dual mode passive-active imaging can be achieved with LETI e-APDs without degradation in the passive imaging performance. The gain and sensitivity performances were measured in test arrays and using a low voltage technology (3.3V) CTIA test pixel designed for 3D active imaging. The CTIA and test arrays measurements yielded comparable results in terms of bias gain dependence (M=100 at Vb=-7V), low excess noise factor (=1.2) and low equivalent input current (Ieq_in<1pA). These results validated the low voltage CTIA approach for integrating the current from a HgCdTe e-APD under high bias. The test array measurements demonstrated a relative dispersion below 2% in both MBE and LPE e- APDs for gains higher than M>100, associated with an operability of 99%. The operability at Ieq_in<1pA at M=30 was 95%. A record low value of Ieq_in=1fA was estimated in the MBE e-APDs at M=100, indicating the potential for using the MW e-APDs for very low flux applications. The high potential of the MW e-APDS for active imaging was demonstrated by impulse response measurements which yielded a typical rise time lower than 100ps and diffusion limited fall time of 900ps to 5ns, depending on the pixel pitch. This potential was confirmed by the demonstration of a 2ns time of flight (TOF) resolution in the CTIA e-APD 3D pixel. The combined photon and dark current induced equivalent back ground noise at f/8 with a cold band pass filter at ?=1.55?m was 2 electrons rms for an integration time of 50ns.

Rothman, Johan; Perrais, Gwladys; De Borniol, Eric; Castelein, Pierre; Baier, Nicholas; Guellec, Fabrice; Tchagaspanian, Michael; Ballet, Philippe; Mollard, Laurent; Gout, Sylvain; Perez, André; Fournier, Maryse; Chamonal, Jean-Paul; Tribolet, Philippe M.; Destefanis, Gerard

2008-05-01

234

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA\\/CD3-bispecific T-cell-engaging BiTE antibody  

Microsoft Academic Search

Background:Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human colorectal cancer (CRC) previously treated with conventional chemotherapy would be sensitive to T-cell killing mediated by carcinoembryonic antigen (CEA)\\/CD3-bispecific T-cell-engaging BiTE antibody (MEDI-565).Methods:We analysed proliferation and lysis of CEA-positive (CEA+) CRC specimens that had survived previous systemic chemotherapy and biologic therapy to determine whether

T Osada; D Hsu; S Hammond; A Hobeika; G Devi; T M Clay; H K Lyerly; M A Morse

2010-01-01

235

Research at the CEA in the field of safety in 2nd and 3rd generation light water reactors  

NASA Astrophysics Data System (ADS)

The research programs at the CEA in the field of safety in nuclear reactors are carried out in a framework of international partnerships. Their purpose is to develop studies on: The methods allowing for the determination of earthquake hazards and their consequences; The behaviour of fuel in an accident situation; The comprehension of deflagration and detonation phenomena of hydrogen and the search for effective prevention methods involving an explosion risk; The cooling of corium in order to stop its progression in and outside the vessel thereby reducing the risk of perforating the basemat; The behaviour of the different fission product families according to their volatility for the UO2 and MOX fuels.

Billot, Philippe

2012-05-01

236

Sandia National Laboratories results for the 2010 criticality accident dosimetry exercise, at the CALIBAN reactor, CEA Valduc France.  

SciTech Connect

This document describes the personal nuclear accident dosimeter (PNAD) used by Sandia National Laboratories (SNL) and presents PNAD dosimetry results obtained during the Nuclear Accident Dosimeter Intercomparison Study held 20-23 September, 2010, at CEA Valduc, France. SNL PNADs were exposed in two separate irradiations from the CALIBAN reactor. Biases for reported neutron doses ranged from -15% to +0.4% with an average bias of -7.7%. PNADs were also exposed on the back side of phantoms to assess orientation effects.

Ward, Dann C.

2011-09-01

237

Evaluation of serum CEA and CA19-9 levels as prognostic factors in patients with gastric cancer  

Microsoft Academic Search

  \\u000a \\u000a Background. This clinicopathological study evaluated the utility of serum carcinoembryonic antigen (CEA) and carbohydrate antigen (CA)\\u000a 19-9 as predictors of locoregional recurrence and long-term disease-free survival in patients with gastric cancer.\\u000a \\u000a \\u000a \\u000a \\u000a Methods. During the period January 1989 to December 1994, 485 patients with primary gastric cancer were evaluated. Gastrectomies were\\u000a performed in 434 patients. Prognostic factors were analyzed by

Mitsugu Kochi; Masashi Fujii; Noriaki Kanamori; Teruo Kaiga; Tetsuya Kawakami; Kazuo Aizaki; Mitsuko Kasahara; Fumiro Mochizuki; Yuichi Kasakura; Motoo Yamagata

2000-01-01

238

Mesure du taux de la capture radiative du muon par l'hydrogene liquide  

NASA Astrophysics Data System (ADS)

À basse énergie, l'interaction faible entre leptons et quarks est décrite par une interaction de la forme courant × courant de type V - A. La présence de l'interaction forte induit des couplages additionnels qui doivent être déterminés expérimentalement. De ceux-ci, le couplage pseudoscalaire induit, gp , est mesuré avec la plus grande incertitude et fait l'objet de la présente recherche. L'hypothèse du Courant Axial Partiellement Conservé (CAPC) et l'usage de la relation de Goldberger-Treiman relie gp au couplage axial ga . Cette relation a été vérifiée traditionnellement par la Capture Ordinaire du Muon (COM) à une valeur fixe du moment de transfert q. La Capture Radiative du Muon (CRM), m- p-->nnmg , est un meilleur outil pour l'étude de gp à cause de sa dépendance variable en q2 qui offre une plus grande sensibilité dans la partie à haute énergie du spectre des photons. Toutefois, le petit rapport d'embranchement (~10-8) de la CRM par rapport à la désintégration du muon a retardé cette mesure jusqu'à ce jour. La théorie et les difficultés expérimentales associées à la détection des photons de CRM sont présentées au deuxième chapitre. On décrit ensuite, au troisième chapitre, les composantes du système de détection. Ce détecteur est un spectromètre à paires de grand angle solide (~3p) et qui permet l'observation des photons par l'analyse des électrons et des positrons de photo-conversion. Ainsi, le bruit de fond important des neutrons de la COM ne constitue pas un problème pour cette mesure. Nous décrivons, au quatrième chapitre, toutes les étapes de l'analyse, nécessaires pour la réduction des multiples bruits de fond. Le cinquième chapitre présente le calcul des efficacités ainsi que l'estimation des erreurs systématiques. Le sixième chapitre démontre comment l'on extrait le rapport d'embranchement pour la CRM ainsi que la valeur ae gp . On insiste sur la dépendance de gp en fonction de la valeur de lop , le taux de transition ortho-à para-moléculaire. Nous avons observé le processus rare de CRM sur le proton pour la première fois à TRIUMF. Le rapport d'embranchement partiel (k > 60 MeV, où k est l'énergie du photon) par rapport à la désintégration du muon est de (2.10 +/- 0.22) × 10-8. Cette valeur correspond à gp = (9.8 +/- 0.7 +/- 0.3) . ga(0) pour la valeur expérimentale de lop .

Jonkmans, Guy

239

[An antitumor effect of oncolytic adenovirus capable of selectively replicating in CEA-expressing cancer cells and its enhancement by 5-FU].  

PubMed

In recent years, many have focused on the use of oncolytic virus capable of lysing cancer cells by a cancer-selective replication for a new treatment modality of cancer. In the present study, we used oncolytic adenovirus, AdCEAp/Rep, genetically modified to selectively replicate in CEA-expressing cancer cells, and investigated whether AdCEAp/Rep could induce selective cytotoxicity to CEA expressing cancer cells, and where the AdCEAp/Rep induced cytotoxic effect could be enhanced by 5 FU in using human gastric cancer cell lines, MKN45 (CEA-positive) and MKN74 (CEA-negative). The results showed that AdCEAp/Rep showed cytotoxicity against MKN45 in a dose-dependent manner, while it did not against MKN74. Furthermore, 5-FU remarkably enhanced AdCEAp/Rep-induced cytotoxicity against MKN45 by being added 3 days after adenovirus infection. These findings strongly suggest that AdCEAp/Rep may be applicable as a new therapeutic agent for clinical cancers expressing CEA in combination with chemotherapeutic agents such as 5-FU. PMID:17212097

Araki, Yasunobu; Fujiwara, Hitoshi; Inada, Satoshi; Atsuji, Kiyoto; Yamagishi, Hisakazu

2006-11-01

240

Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy: Correlation of liver scan, liver function tests, and plasma CEA with tumor response  

SciTech Connect

Sixteen patients with metastatic disease to the liver (12 colorectal and four unknown primary tumors) were treated in a pilot study of hepatic irradiation (2500-3000 rads in 10-12 fractions) delivered concomitantly with continuous short-term intraarterial infusion of 5-fluorouracil (1 g/d) or FUDR (0.5 mg/kg/d) via a percutaneously placed hepatic artery catheter. Abnormal liver function tests, including SGOT, LDH, and alkaline phosphatase, decreased in all patients by day 7-10 of treatment, and other metabolic factors, including serum cholesterol, calcium, albumin, phosphorous, and uric acid, also decreased, often to subnormal levels by termination of treatment (day 15-20). These chemical alterations did not correlate with tumor response in that the identical pattern was observed in responders (ten patients) as well as nonresponders (six patients). Objective determinants of response were assessed by serial monitoring of plasma carcinoembryonic antigen (CEA) and liver scan. In 14 patients with elevated CEA levels, tumor response (nine patients), nonresponse (four patients), and relapse (five patients) was predicted and confirmed by sequential monitoring of CEA. In one patient, a paradoxical decrease in plasma CEA was associated with progressive disease. The liver scan identified all responding patients but was difficult to quantitate and was delayed for months following subjective clinical response and changes in plasma CEA levels.

Lokich, J. (New England Deaconess Hospital, Boston, MA); Kinsella, T.; Perri, J.; Malcolm, A.; Clouse, M.

1981-12-15

241

Concomitant hepatic radiation and intraarterial fluorinated pyrimidine therapy: correlation of liver scan, liver function tests, and plasma CEA with tumor response  

SciTech Connect

Sixteen patients with metastatic disease to the liver (12 colorectal and four unknown primary tumors) were treated in a pilot study of hepatic irradiation (2500-3000 rads in 10-12 fractions) delivered concomitantly with continuous short-term intraarterial infusion of 5-fluorouracil (1 g/d) or FUDR (0.5 mg/kg/d) via a percutaneously placed hepatic artery catheter. Abnormal liver function tests, including SGOT, LDH, and alkaline phosphatase, decreased in all patients by day 7-10 of treatment, and other metabolic factors, including serum cholesterol, calcium, albumin, phosphorous, and uric acid, also decreased, often to subnormal levels by termination of treatment (day 15-20). These chemical alterations did not correlate with tumor response in that the identical pattern was observed in responders (ten patients) as well as nonresponders (six patients). Objective determinants of response were assessed by serial monitoring of the plasma carcinoembryonic antigen (CEA) and liver scan. In 14 patients with elevated CEA levels, tumor response (nine patients), nonresponse (four patients), and relapse (five patients) was predicted and confirmed by sequential monitoring of CEA. In one patient, a paradoxical decrease in plasma CEA was associated with progressive disease. The liver scan identified all responding patients but was difficult to quantitate and was delayed for months following subjective clinical response and changes in plasma CEA levels.

Lokich, J.; Kinsella, T.; Perri, J.; Malcolm, A.; Clouse, M.

1981-12-15

242

Intensive post-operative follow-up of breast cancer patients with tumour markers: CEA, TPA or CA15.3 vs MCA and MCA-CA15.3 vs CEA-TPA-CA15.3 panel in the early detection of distant metastases  

Microsoft Academic Search

BACKGROUND: In breast cancer current guidelines do not recommend the routine use of serum tumour markers. Differently, we observed that CEA-TPA-CA15.3 (carcinoembryonic (CEA) tissue polypeptide (TPA) and cancer associated 115D8\\/DF3 (CA15.3) antigens) panel permits early detection and treatment for most relapsing patients. As high sensitivity and specificity and different cut-off values have been reported for mucin-like carcinoma associated antigen (MCA),

Andrea Nicolini; Gianna Tartarelli; Angelo Carpi; Maria Rita Metelli; Paola Ferrari; Loretta Anselmi; Massimo Conte; Piero Berti; Paolo Miccoli

2006-01-01

243

Proper Motions from Carte DU Ciel Plates  

NASA Astrophysics Data System (ADS)

The existing data on proper motions from meridian catalogues and proper motion surveys appear to be reasonably complete for motions larger than 0.24 arc seconds per year and down to the 19th magnitude visual but for motions between 0.24 and 0.18 there exists a lacuna for stars between 8.5 and 11.5 visual which could easily be observed by repeating Carte du Ciel plates.

Luyten, W. J.

244

Examens médicaux périodiques en médecine du travail  

Microsoft Academic Search

Résumé Les objectifs principaux des examens médicaux périodiques (EMP) en médecine du travail sont les suivants (rapport technique OMS 1973): déceler une altération précoce de la santé, évaluer l'efficacité des mesures préventives, dépister les sujets hypersensibles, dégager les tendances de l'état de santé de groupes de travailleurs, indiquer la nécessité d'un traitement médical. Tout programme de prévention médicale exige parallèlement

M. Lob

1975-01-01

245

Maladie de Castleman: localisation inhabituelle du thorax  

PubMed Central

La maladie de Castleman est une affection rare qui peut toucher le thorax. La localisation diaphragmatique est exceptionnelle. Nous rapportons le cas d'une patiente de 47 ans, chez qui une thoracotomie exploratrice a permis l'exérèse d'une masse du sinus médiastinal antérieur droit, en continuité avec le diaphragme et dont l'histologie est en faveur de la maladie de Castleman de type hyalino-vasculaire. Les particularités cliniques, radiologiques et évolutives ont été revues.

Eloueriachi, Faycal; Caidi, Mohammed; Zouaidia, Fouad; Ouchen, Fahd; Maidi, Mehdi; Fennane, Hicham; Bouchikh, Mohamed; Achir, Abdellah; Benosman, Abdellatif

2012-01-01

246

Capital humain et emploi du temps  

Microsoft Academic Search

L'hypothese sur laquelle se fonde le present article est que les bases de donnees sur l'emploi du temps permettent d'obtenir un apercu plus large des avantages et des couts de l'investissement en capital humain. Il s'agit d'un ensemble de donnees integrees portant non seulement sur le niveau de scolarite, mais aussi sur le temps consacre a l'education formelle et informelle,

Frank Jones

1995-01-01

247

Aspects de la médecine du travail  

Microsoft Academic Search

Résumé Tour d'horizon portant sur diverses questions touchant l'état actuel et l'avenir de la médecine du travail et de l'hygiène industrielle en Suisse. Rappel historique, structures actuelles, nécessité d'une approche multidisciplinaire. Problèmes posés par les effets à long terme, sécurité trompeuse donnée par les statistiques, difficultés d'interprétation de valeurs biologiques «subnormales». Exigences, nécessité et limites de la législation. Réflexions sur

M. Lob

1981-01-01

248

Cristallisation dans les verres de silicates contenant du molybdène et du phosphore  

NASA Astrophysics Data System (ADS)

L'ajout de certains oxydes dans un verre initialement homogène peut entraîner des cristallisations plus ou moins importantes du mélange lors de son refroidissement. Parmi les oxydes connus pour induire de tels phénomènes dans des verres de silicates, se trouvent l'oxyde de molybdène MoO{3} et l'oxyde de phosphore P{2}O{5}. Les matériaux étudiés ici sont des verres silico-sodo-calciques auxquels ont été ajoutés MoO{3} et P{2}O{5} en quantité variable, ce qui provoque des cristallisations importantes. L'identification et la quantification des phases cristallines en présence par MEB et méthode Rietveld à partir des diffractogrammes permettent de comprendre les rôles respectifs du molybdène et du phosphore dans les phénomènes de cristallisation intervenant dans ces verres. Mots-clés: verres d'oxydes, cristallisation, diffraction des rayons X

Cousi, C.; Bart, F.; Phalippou, J.

2004-11-01

249

EFFETS DU CADMIUM SUR LA FORMATION DU PHOSPHOGYPSE LORS DE LA PRODUCTION DE L'ACIDE PHOSPHORIQUE  

Microsoft Academic Search

La teneur maximale en cadmium atteinte dans le phosphogypse préparé selon la voie humide en utilisant une attaque sulfurique du phosphate apatitique est de l'ordre de 0.62%. A faibles concentrations en ions cadmium (inférieur à 0.26%), l'analyse physico-chimie du phosphogypse montre que le cadmium est substitué aux ions calcium dans les phases du sulfate de calcium et de la brushite.

R. Bchitou; M. Hamad; J. L. Lacout; M. Ferhat

1998-01-01

250

Les citoyens, allies du systeme de sante.  

PubMed

De nombreuses déclarations internationales reconnaissent la participation citoyenne comme un levier important de succès des politiques de santé. Cependant, la mise en œuvre de ce principe tarde dans la plupart des pays. Des phénomènes bien connus, comme celui du vieillissement, et les coûts qu'ils engendrent, devraient pourtant inciter les décideurs à s'appuyer davantage sur les citoyens, en faire des alliés du système, en leur accordant un peu de pouvoir et de responsabilité. Cette responsabilité s'exerce d'abord dans la prévention et la promotion de la santé. Elle s'étend à l'entraide communautaire. Elle est sollicitée dans la détermination des nouvelles normes sociales. Elle est reconnue par la participation des citoyens aux instances décisionnelles du système de soins. Et elle s'applique lorsque vient le temps choisir quels services de santé seront couverts par le régime public et lesquels seront renvoyés à la prévoyance personnelle. Les raisons de faire une place aux citoyens dans nos systèmes de santé sont nombreuses. Les moyens pour le faire existent. Il faut une volonté politique et des ressources. PMID:24737815

Venne, Michel

2014-03-01

251

Proprietes de Transport Electronique DU Rutile Stoechiometrique  

NASA Astrophysics Data System (ADS)

Le rutile est un oxyde metallique qui presente beaucoup de similitudes avec certains perovskites notamment le titanate de barium ou de strontium. Il est comme ces derniers, compose d'un agencement d'octaedres d'oxygene centres sur l'atome de titane. Ces octaedres sont responsables de la forte polarisabilite de ces cristaux et de leur grande constante dielectrique. Leurs proprietes optiques, seuil d'absorption et spectre de phonons, sont par exemple forts semblables. La presente etude vise a determiner la nature du transport electronique dans le rutile stoechiometrique pur et d'en comparer les resultats avec les proprietes de certains perovskites. Nous determinerons par differentes mesures optoelectroniques les parametres caracteristiques des pieges et leur influence sur le transport des electrons et des trous. Les resultats de conductivite et de capacitance de meme que les spectres de photoconductivite dans nos echantillons ont mis en evidence la presence d'au moins cinq niveaux energetiques dans la bande interdite du rutile agissant comme pieges pour les electrons ou pour les trous et qui jouent un role de premiere importance dans le comportement electrique du rutile. Par la technique de charge transitoire, nous determinerons pour la premiere fois dans le rutile stoechiometrique la grandeur de la mobilite de derive des trous a la temperature ambiante soit 3,4 cm^2/V cdots et nous etablierons une borne superieure a la mobilite des electrons soit 0,1 cm^2 /Vcdots.

Keroack, Danielle

252

Ultra low dark current CdHgTe FPAs in the SWIR range at CEA and Sofradir  

NASA Astrophysics Data System (ADS)

We report here first results carried out at CEA and Sofradir to build ultra low dark current focal plane arrays (FPA) in the short wave infrared range (SWIR) for space applications. Those FPAs are dedicated to very low flux detection in the 2?m wavelength range. In this purpose, Sofradir has designed a source follower per detector readout circuit (ROIC), 384x288, 15?m pitch. This ROIC has been hybridized on different HgCdTe diode configurations processed at CEALETI and low flux characterisations have been carried out at CEA-SAp at low temperature (from 60 to 160K). Both p/n and n/p structures have been evaluated. The metallurgical nature of the absorbing layer is also examined and both molecular beam epitaxy (MBE) and liquid phase epitaxy (LPE) have been processed. Dark current measurements are discussed in comparison with previous results from the literature. State of the art dark currents are recorded for temperatures higher than 120K. At temperatures lower than 100K, the decrease in dark current saturates for both technologies. In this regime, currents between 0.4 and 0.06 e/s/pixel are reported.

Gravrand, O.; Mollard, L.; Boulade, O.; Moreau, V.; Sanson, E.; Destéfanis, G.

2011-10-01

253

The CEA Second-Look Trial: a randomised controlled trial of carcinoembryonic antigen prompted reoperation for recurrent colorectal cancer  

PubMed Central

Objective In patients who have undergone a potentially curative resection of colorectal cancer, does a ‘second-look’ operation to resect recurrence, prompted by monthly monitoring of carcinoembryonic antigen, confer a survival benefit? Design A randomised controlled trial recruiting patients from 1982 to 1993 was recovered under the Restoring Invisible and Abandoned Trials (RIAT) initiative. Setting 58 hospitals in the UK. Participants From 1982 to 1993, 1447 patients were enrolled. Of these 216 met the criteria for carcinoembryonic antigen (CEA) elevation and were randomised to ‘Aggressive’ or ‘Conventional’ arms. Interventions ‘Second-look’ surgery with intention to remove any recurrence discovered. Primary outcome measure Survival. Results By February 1993, 91/108 patients had died in the ‘Aggressive arm’ and 88/108 in the ‘Conventional’ arm (relative risk=1.16, 95% CI 0.87 to 1.37). By 2011 a further 25 randomised patients had died. Kaplan-Meier analysis showed no difference in long-term survival. Conclusions The trial was closed in 1993 following a recommendation from the Data Monitoring Committee that it was highly unlikely that any survival advantage would be demonstrated for CEA prompted second-look surgery. This conclusion was confirmed by repeat analysis of survival times after 20?years. Trial registration number ISRCTN76694943.

Treasure, Tom; Monson, Kathryn; Fiorentino, Francesca; Russell, Christopher

2014-01-01

254

Giant splenic epithelial cyst with elevated serum markers CEA and CA 19-9 levels: an incidental association?  

PubMed

True spleen cysts are uncommon and rarely associated with elevated serum and intracystic tumor markers CA 19-9 and CEA levels. A 19-year-old woman with a left subcostal mass was observed. Echinococcus granulosus serology was negative, and serum tumor markers CA 19-9 and CEA levels were 273 kU/L and 33 ng/mL, respectively. CT-scanning showed a splenic cyst of 18 cm in greatest diameter. The patient underwent total laparoscopic splenectomy and the serum tumor markers progressively decreased and became normal three months after surgery. Splenic cysts derive from an invagination of the splenic capsule in the splenic pulp with a subsequent squamous metaplasia. This last evidence could be confirmed from the variable cellular differentiation lines of the mesothelial squamous cells in the cyst wall. We should not exclude a higher degenerative potential of cystic epithelium that produces de-differentiation proteins. The lowering of the serum levels of the two markers after the cyst removal is witness of the direct relationship between the increment of the serum tumor markers and the presence of the epidermoid cyst. PMID:12680182

Madia, Carmelo; Lumachi, Franco; Veroux, Massimiliano; Fiamingo, Pietro; Gringeri, Enrico; Brolese, Alberto; Zanus, Giacomo; Cillo, Umberto; D'Amico, Davide F

2003-01-01

255

Simulating Evolution  

ERIC Educational Resources Information Center

Described are simulations that can be used to illustrate evolution by natural selection. Suggestions for simulating phenomena such as adaptive radiation, color match to background and vision of predators are offered. (BR)

Stebbins, Robert C.; Allen, Brockenbrough

1975-01-01

256

Evolution Observed.  

ERIC Educational Resources Information Center

Discusses various possible ways by which isolated populations might differentiate into species. The interactions between ecological factors and genes with respect to evolution and the role of genetic polymorphisms and other genetics variation are also discussed. (HM)

Angseesing, J. P. A.

1978-01-01

257

Developments and fabrication of laser targets used to prepare inertial confinement fusion (ICF) experiments on CEA Laser ``M'egajoule'' (LMJ) facility  

NASA Astrophysics Data System (ADS)

A micro materials and technologies research program has started in France since 10 years to develop a very complex cryogenic target to reach the combustion of a deuterium tritium mixture, by indirect drive on the CEA Laser ``M'egajoule'' (LMJ) facility. This mixture is contained by an amorphous hydrogenated carbon (a-C:H or CHx) doped with germanium capsule placed in the center of a hohlraum. This research program involves CEA scientists, engineers and technicians united to realize specific targets for carrying out laser plasma experiments on the CEA LIL ``Ligne d'Int'egration Laser'' or OMEGA-UPGRADE facilities. To achieve the production of such specific targets different technologies are successively used (coating, precision machining, laser machining, characterizations, assembling, etc). This article presents an illustration of these microtechnology realizations through particular complex laser targets for hydrodynamic, or parametric instabilities studies and for symmetry experimental effects studies on fusion burn.

Bednarczyk, Sophie; Durut, Frédéric; Reneaume, Benoît; Théobald, Marc; Casner, Alexis; Tassin, Véronique; Monteil, Marie-Christine; Galmich, Didier

2008-11-01

258

Human Evolution  

NSDL National Science Digital Library

This resource from PBS focuses on human evolution in a format aimed at kids but easily adapted to a classroom of any kind. A classroom activity (available as Shockwave or text only formats) describes the steps in human evolution (physically and behaviorally) from Ardipithecus ramidus about 4.4 million years ago to our current state as modern Homo sapiens. There are also brief summaries of the importance of Lucy, fossilized footprints, and the "Taung child," the first Autralopithecus specimen found.

1969-12-31

259

Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis  

PubMed Central

Background Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF), serum CEA levels, and EGFR and HER2 tissue-expression in brain metastasis (BM) and overall survival (OS) in patients with advanced NSCLC. Methods In a prospective manner, we studied 293 patients with NSCLC in IIIB-IV clinical stage. They received standard chemotherapy. CEA was measured prior to treatment; EGFR and HER2 were evaluated by immunohistochemistry. BM development was confirmed by MRI in symptomatic patients. Results BM developed in 27, and 32% of patients at 1 and 2 years of diagnosis with adenocarcinoma (RR 5.2; 95% CI, 1.002–29; p = 0.05) and CEA ? 40 ng/mL (RR 11.4; 95% CI, 1.7–74; p < 0.01) as independent associated factors. EGFR and HER2 were not statistically significant. Masculine gender (RR 1.4; 95% CI, 1.002–1.9; p = 0.048), poor performance status (RR 1.8; 95% CI, 1.5–2.3; p = 0.002), advanced clinical stage (RR 1.44; 95% CI, 1.02–2; p = 0.04), CEA ? 40 ng/mL (RR 1.5; 95% CI, 1.09–2.2; p = 0.014) and EGFR expression (RR 1.6; 95% CI, 1.4–1.9; p = 0.012) were independent associated factors to worse OS. Conclusion High CEA serum level is a risk factor for BM development and is associated with poor prognosis in patients with advanced NSCLC. Surface expression of CEA in tumor cells could be the physiopathological mechanism for invasion to CNS.

2009-01-01

260

The effect of sodium butyrate and retinoic acid on growth and CEA production in a series of human colorectal tumor cell lines representing different states of differentiation.  

PubMed

The effect of sodium butyrate and retinoic acid added singly or in combination on substrate-dependent growth, colonization efficiency in soft agar, and carcino-embryonic antigen (CEA) production in three human colorectal carcinoma cell lines differing in their degree of differentiation was studied. All three colon cancer cell lines regardless of their state of differentiation had their growth markedly slowed by sodium butyrate, and to a lesser extent by retinoic acid. When both agents were added together, a small synergistic inhibition of growth was noted in all the cell lines. Butyrate eliminated colony formation in soft agar in all three cell lines, however, retinoic acid only reduced colony formation in the well differentiated cell line DLD-2. Sodium butyrate was able to induce CEA production in the undifferentiated cell (MIP-101) and the moderately differentiated cells (clone D) which were previously negative for this marker. It also enhanced the baseline production of CEA in the well differentiated cells (DLD-2). Retinoic acid did not induce CEA production in clone D or MIP-101 cells, but did enhance the production of CEA in DLD-2 cells. When both retinoic acid and sodium butyrate were added together, CEA production was either additive (DLD-2) or was inhibited (clone D and MIP-101). One explanation of these results is that only well differentiated cells have functional cellular retinoic acid-binding protein (cRABP), and that certain actions of retinoic acid (inhibition of anchorage-dependent growth) are independent of the presence of cRABP. PMID:3365571

Niles, R M; Wilhelm, S A; Thomas, P; Zamcheck, N

1988-01-01

261

Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers.  

PubMed

To investigate the prognostic value of tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels at diagnosis of systemic recurrence. After primary treatments of locoregional breast cancers, serum CA 15-3 and/or CEA concentrations were regularly measured, and systemic recurrences were identified in 351 patients between January 1999 and December 2009. The association between tumor marker levels at systemic recurrence and survival were investigated by univariate and multivariate analyses. Elevated CA 15-3 and CEA levels were identified in 194 of 349 (55.6 %) and 111 of 308 (36.0 %) patients, respectively, at diagnosis of systemic recurrence. Elevated levels of CA 15-3 and CEA were correlated with visceral or multiple recurrences and elevated preoperative levels. Elevation of CA 15-3 was more prominent in younger patients and in primary node-positive tumors, while CEA was elevated in older patients at diagnosis and in estrogen receptor (ER)-positive tumors. Elevated tumor markers as well as ER negativity, short disease-free interval, and advanced stage at initial diagnosis showed independent prognostic significance on multivariate analysis. Among 306 patients for whom levels of both tumor markers at recurrence were available, 106 patients without elevation of either marker showed significantly better overall survival than those with elevated levels of either one or both markers, and the significance persisted in multivariate analysis. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients. PMID:24072270

Lee, Jun Sang; Park, Seho; Park, Ji Min; Cho, Jung Hoon; Kim, Seung Il; Park, Byeong-Woo

2013-10-01

262

A randomized pilot phase I study of modified carcinoembryonic antigen (CEA) peptide (CAP1-6D)/montanide/GM-CSF-vaccine in patients with pancreatic adenocarcinoma  

PubMed Central

Background CEA is expressed in >90% of pancreatic cancers (PC) and may be an appropriate immunotherapy target. CEA is poorly immunogenic due to immune tolerance; CAP1-6D, an altered peptide ligand can help bypass tolerance. We conducted a pilot randomized phase I trial in PC patients to determine the peptide dose required to induce an optimal CD8+ T cell response. Methods Patients with a PS 0-1, HLA-A2+ and CEA-expressing, previously-treated PC were randomized to receive 10 ?g (arm A), 100 ?g (arm B) or 1000 ?g (arm C) of CEA peptide emulsified in Montanide and GM-CSF, given every 2 weeks until disease progression. Results Sixty-six patients were screened and 19 enrolled of whom 14 received at least 3 doses of the vaccine and thus evaluated for the primary immunologic endpoint. A median of 4 cycles (range 1-81) was delivered. Median and mean peak IFN-? T cell response by ELISPOT (spots per 104 CD8+ cells, Arm A/B/C) was 11/52/271 (A vs. C, p?=?0.028) for medians and 37/148/248 (A vs. C, p?=?0.032) for means. T cell responses developed or increased in 20%/60%/100% of pts in Arms A/B/C. Seven of the 19 patients remain alive at a minimum 32 months from trial initiation, including three with unresectable disease. Conclusions The T cell response in this randomized phase I trial was dose-dependent with the 1 mg CEA peptide dose eliciting the most robust T cell responses. A signal of clinical benefit was observed and no significant toxicity was noted. Further evaluation of 1 mg CEA peptide with stronger adjuvants, and/or combined with agents to overcome immune inhibitory pathways, may be warranted in PC pts. Trial registration ClinicalTrials.gov NCT00203892

2013-01-01

263

Les entreprises françaises à l'heure du brevet européen  

Microsoft Academic Search

[fre] Les entreprises françaises à l'heure du brevet européen . Depuis son entrée en vigueur en 1 978, le brevet européen a connu une croissance régulière auprès des déposants français, passant de près de 2 000 demandes en 1 979 à un peu plus du double dix ans plus tard. Les déposants sont, dans une grande mesure, des personnes morales,

Jean-Christophe Bussy; Isabelle Kabla; Catherine Carpentier

1994-01-01

264

Implementation et performances du protocole de routage DSR  

Microsoft Academic Search

Dans cet article, nous proposons une formulation du problème de routage dans les réseaux mobiles ad hoc. Pour résoudre ce problème, nous proposons d’utiliser le protocole DSR (Dynamic Source Routing) que nous avons implémenté à partir du simulateur de réseau NS-2. Les résultats de simulation montrent que le protocole DSR est efficace sous une faible intensité de trafic et une

Ronald Beaubrun; Badji Molo

2008-01-01

265

Persistance du chômage, répartition des revenus et qualifications  

Microsoft Academic Search

[fre] Persistance du chômage, répartition des revenus et qualifications . Depuis le milieu des années soixante-dix, le taux de chômage a augmenté, en France comme en Europe, de près de 10 points. Aux États-Unis, le taux est le même en 1995 que vingt ans auparavant. Les deux explications les plus pertinentes à la persistance du chômage européen et à la

Henri Sneessens

1995-01-01

266

Participation des m?decins g?n?ralistes de la province de Benimellal (Maroc) dans le d?pistage du cancer du col  

PubMed Central

Introduction Au Maroc, chaque année il y aurait environ 2000 nouveaux cas de cancer du col et les 2/3 des cas sont pris en charge à un stade très avancé. Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Méthodes Nous avons mené une étude transversale, exhaustive incluant les 71 médecins généralistes exerçant dans les établissements de soins de santé de base du secteur public et privé de la province de Benimellal. Le but était d’évaluer leurs connaissances et leur participation au dépistage du cancer du col. Résultats Le niveau de connaissance était relativement modeste, 22 médecins généraliste avaient répondu à la question sur l'incidence du cancer du col au Maroc, Parmi eux (81,8%) avaient donné une réponse incorrecte. L'Herpes Papilloma virus comme facteur de risque du cancer du col a été identifié par seulement 21% des médecins généralistes. La participation au dépistage était également défaillante, 92,8% n'avaient jamais pratiqué le FCV chez leurs patientes à cause principalement du manque de formation (95,5%). Conclusion Les résultats montrent la nécessité d'améliorer les connaissances théoriques et pratique des médecins généralistes concernant le dépistage du cancer du col.

Nani, Samira; Benallal, Mohamed; Hassoune, Samira; Kissi, Dounia; Maaroufi, Abderrahmane

2013-01-01

267

Submillimetre/TeraHertz Astronomy at Dome C with CEA Filled Bolometer Array  

NASA Astrophysics Data System (ADS)

Submillimetre/TeraHertz (e.g. 200, 350, 450 ?m) astronomy is the prime technique to unveil the birth and early evolution of a broad range of astrophysical objects. A major obstacle to carry out submm observations from ground is the atmosphere. Preliminary site testing and atmospheric transmission models tend to demonstrate that Dome C could offer the best conditions on Earth for submm/THz astronomy. The CAMISTIC project aims to install a filled bolometer-array camera with 16×16 pixels on IRAIT at Dome C and explore the 200-?m windows for potential ground-based observations.

Minier, V.; Durand, G.; Lagage, P.-O.; Talvard, M.; Travouillon, T.; Busso, M.; Tosti, G.

268

Evolution Website  

NSDL National Science Digital Library

The BBC offers this site as one of their newer online educational resources. Organized into nine sections, Evolution Website gives the viewer lessons of "4,000 million years crammed into one website." Sections include The Man And His Legacy (Charles Darwin), The Origin Online (full text of Darwin's famous publication), Bibliography (including electronic resources), Debate (contributions from an earlier debate on Evolution), Alife (the game Biotopia), Life on earth (text from David Attenborough's famed series), Extinction Files (all about extinctions), Fossil Roadshow (with RealVideo fossil coverage), and Natural Selections (a series of short films on especially inspiring animals). For anyone interested in teaching evolution, this collection of educational materials includes numerous helpful learning tools.

269

Modelisation par elements finis du muscle strie  

NASA Astrophysics Data System (ADS)

Ce present projet de recherche a permis. de creer un modele par elements finis du muscle strie humain dans le but d'etudier les mecanismes engendrant les lesions musculaires traumatiques. Ce modele constitue une plate-forme numerique capable de discerner l'influence des proprietes mecaniques des fascias et de la cellule musculaire sur le comportement dynamique du muscle lors d'une contraction excentrique, notamment le module de Young et le module de cisaillement de la couche de tissu conjonctif, l'orientation des fibres de collagene de cette membrane et le coefficient de poisson du muscle. La caracterisation experimentale in vitro de ces parametres pour des vitesses de deformation elevees a partir de muscles stries humains actifs est essentielle pour l'etude de lesions musculaires traumatiques. Le modele numerique developpe est capable de modeliser la contraction musculaire comme une transition de phase de la cellule musculaire par un changement de raideur et de volume a l'aide des lois de comportement de materiau predefinies dans le logiciel LS-DYNA (v971, Livermore Software Technology Corporation, Livermore, CA, USA). Le present projet de recherche introduit donc un phenomene physiologique qui pourrait expliquer des blessures musculaires courantes (crampes, courbatures, claquages, etc.), mais aussi des maladies ou desordres touchant le tissu conjonctif comme les collagenoses et la dystrophie musculaire. La predominance de blessures musculaires lors de contractions excentriques est egalement exposee. Le modele developpe dans ce projet de recherche met ainsi a l'avant-scene le concept de transition de phase ouvrant la porte au developpement de nouvelles technologies pour l'activation musculaire chez les personnes atteintes de paraplegie ou de muscles artificiels compacts pour l'elaboration de protheses ou d'exosquelettes. Mots-cles Muscle strie, lesion musculaire, fascia, contraction excentrique, modele par elements finis, transition de phase

Leonard, Mathieu

270

Identification d'une loi thermo-élasto-viscoplastique en vue de la modélisation du laminage à chaud du cuivre  

NASA Astrophysics Data System (ADS)

la mise au point d'un modèle de simulation de la dernière passe du laminage à chaud du cuivre ne présente à priori pas de problème du point de vue numérique pour un code d'éléments finis non linéaire. La collecte d'informations précises tant sur le procédé industriel que sur le comportement du matériau est par contre une opération non triviale. Cet article présente les diverses méthodes expérimentales mises en œuvre pour caractériser le matériau : essais de compression à chaud, mesures d'analyse thermique différentielle, essais de dilatométrie et de diffusivité. Les méthodes permettant d'identifier les paramètres de la loi élasto-visco-plastique de type Norton-Hoff à partir des essais sont présentées et une analyse bibliographique investigue le problème de la détermination du module de Young à haute température. Tant les hypothèses supplémentaires relatives au procédé et nécessaires au modèle que les résultats finaux sont résumés.

Moureaux, P.; Moto Mpong, S.; Remy, M.; Bouffioux, C.; Lecomte-Beckers, J.; Habraken, A. M.

2002-12-01

271

Application of the New Decommissioning Regulation to the Nuclear Licensed Facilities (NLF) at Fontenay-aux-Roses's Nuclear Center (CEA)  

SciTech Connect

This abstract describes the application of the new decommissioning regulation on all Nuclear Licensed Facilities (NLF is to say INB in French) at Fontenay-aux-Roses's Center (CEA/FAR). The decommissioning process has been applied in six buildings which are out of the new nuclear perimeter proposed (buildings no 7, no 40, no 94, no 39, no 52/1 and no 32) and three buildings have been reorganized (no 54, no 91 and no 53 instead of no 40 and no 94) in order to increase the space for temporary nuclear waste disposal and to reduce the internal transports of nuclear waste on the site. The advantages are the safety and radioprotection improvements and a lower operating cost. A global safety file was written in 2002 and 2003 and was sent to the French Nuclear Authority on November 2003. The list of documents required is given in the paragraph I of this paper. The main goals were two ministerial decrees (one decree for each NLF) getting the authorization to modify the NLF perimeter and to carry out cleaning and dismantling activities leading to the whole decommissioning of all NLF. Some specific authorizations were necessary to carry out the dismantling program during the decommissioning procedure. They were delivered by the French Nuclear Safety Authority (FNSA) or with limited delegation by the General Executive Director (GED) on the CEA Fontenay-aux-Roses's Center, called internal authorization. Some partial dismantling or decontamination examples are given below: - evaporator for the radioactive liquid waste treatment station (building no 53): FNSA authorization: phase realised in 2002/2003. - disposal tanks for the radioactive liquid waste treatment station (building no 53) FNSA authorization: phase realised in 2004, - incinerator for the radioactive solid waste treatment station (building no 07): FNSA authorization: operation realised in 2004, - research equipments in the building no. 54 and building no. 91: internal authorization ; realised in 2005, - sample-taking to characterize solvent contained in one tank of Petrus installation (NLF 57, building 18) for radiological and chemical analysis needed to prepare the treatment and the evacuation of these wastes : internal authorization ; realised in june 2005. It was possible to plan the whole decommissioning process on the Nuclear Licensed Facilities of Fontenay-aux-Roses's Center (CEA/FAR) taking into account the French new regulation and to plan a coherent and continue program activity for the dismantling process. For the program not to be interrupted during the administrative process (2003-2006), specific authorisations have been delivered by the French Nuclear Safety Authority or by the General Executive Director (GED) on the CEA Fontenay-aux- Roses's Center (internal authorization). The time schedule to complete the entire program is until 2017 for NLF 'Procede' (NLF no 165) and until 2018 for NLF 'Support' (NLF no 166). Since 1999, an annual press meeting has been organised by the Fontenay-aux-Roses's Center Head Executive Manager.

Sauret, Josiane [Commissariat a l'Energie Atomique, Direction du Centre de Fontenay-aux-Roses, Cellule de Surete nucleaire, de controle des Matieres, de controle des Transports et de la Qualite, 18 route du Panorama BP 6 - 92265 Fontenay-aux-Roses Cedex (France); Piketty, Laurence; Jeanjacques, Michel [Commissariat a l'Energie Atomique, Direction de l'Energie Nucleaire, Direction deleguee des Activites Nucleaires de Saclay, Departement des Reacteurs et des Services Nucleaires, service d'Assainissement de Fontenay-aux-Roses, 18 route du Panorama BP 6 - 92265 Fontenay-aux-Roses Cedex (France)

2008-01-15

272

Monitoring the FLASH Cryomodule Transportation from DESY Hamburg to CEA Saclay: Coupler Contact, Vacuum, Acceleration and Vibration Analysis  

SciTech Connect

With a view to the series production of one hundred, 12 m long XFEL 1.3 GHz cryomodules and their transportation from the assembly site at CEA Saclay (F) to the installation site at DESY Hamburg (D) a test transportation of a FLASH cryomodule has been performed, in the condition foreseen for the mass transportation. The present study examines the stresses induced on the module and verifies the damping capabilities of the transport frame in order to minimize risk of damage to the most critical components. During the transportation, acceleration and vibration have been monitored as well as coupler antenna contacts and vacuum performances. This paper describes the analysis performed and compares those results to the data of a similar transportation study at Fermilab for the CM1 cryomodule.

Barbanotti, S.; Bosotti, A.; Fusetti, M.; Michelato, P.; /INFN, Milan /LASA, Segrate; Bertolini, A.; /Hannover, Max Planck Inst. Grav.; Berry, S.; Dorlot, M.; Madec, C.; Napoly, O.; /Saclay; Amirikas, R.; Boehnert, M.; /DESY /Fermilab

2009-05-01

273

Serum tetranectin is an independent prognostic marker in colorectal cancer and weakly correlated with plasma suPAR, plasma PAI-1 and serum CEA.  

PubMed

Soluble tetranectin (TN) was measured preoperatively in serum from 567 patients with primary colorectal cancer and levels were tested for association with prognosis. The prognostic significance of TN was also compared to that of plasminogen-activator inhibitor-1 (PAI-1), urokinase plasminogen activator (uPAR) and carcinoembryonic antigen (CEA). Significantly shorter survival was found for patients with TN levels below a cut-off point of 7.5 mg/l compared to patients with levels above, as illustrated by Kaplan-Meier curves. By Cox analyses, log TN, log soluble uPAR as well as log CEA were found to have an independent prognostic value for survival (log TN: HR = 0.47, 95% CI: 0.29-0.76); log soluble uPAR: HR = 1.65, 95% CI: 1.18-2.31; log CEA: HR = 1.I1, 95% CI: 1.03-1.20). Based on the multivariate model, a patient with a combination of low levels of TN and PAI-1 and elevated levels of soluble uPAR and CEA had a 2.43 increased risk as compared to a patient with median levels of these biochemical markers. Significant correlations were found with Dukes' stages for all the biochemical markers and between the respective biochemical markers. The findings confirm that TN is a strong prognostic factor in patients with colorectal cancer. TN may be valuable as a prognostic variable in future studies evaluating new treatment strategies for colorectal cancer. PMID:12529016

Høgdall, Claus K; Christensen, Ib J; Stephens, Ross W; Sørensen, Steen; Nørgaard-Pedersen, Bent; Nielsen, Hans J

2002-09-01

274

Aptamers directly radiolabeled with technetium-99m as a potential agent capable of identifying carcinoembryonic antigen (CEA) in tumor cells T84.  

PubMed

Aptamers are small oligonucleotides that are selected to bind with high affinity and specificity to a target molecule. Aptamers are emerging as a new class of molecules for radiopharmaceutical development. In this study a new method to radiolabel aptamers with technetium-99m ((99m)Tc) was developed. Two aptamers (Apt3 and Apt3-amine) selected against the carcinoembryonic antigen (CEA) were used. Labeling was done by the direct method and the developed complex was subjected to quality control tests. Radiochemical purity and stability were monitored by Thin Layer Chromatography. Binding and specificity assays were carried out in the T84 cell line (CEA+) to evaluate tumor affinity and specificity after radiolabeling. Aptamers were successfully labeled with (99m)Tc in high radiochemical yields, showing in vitro stability in presence of plasma and cystein. In binding assays the radiolabeled aptamer Apt3-amine showed the highest affinity to T84 cells. When evaluated with HeLa cells (CEA-), lower uptake was observed, suggesting high specificity for this aptamer. These results suggest that the Apt3-amine aptamer directly labeled with (99m)Tc could be considered a promising agent capable of identifying the carcinoembryonic antigen (CEA) present in tumor cells. PMID:24675379

Correa, Cristiane Rodrigues; de Barros, André Luís Branco; Ferreira, Carolina de Aguiar; de Goes, Alfredo Miranda; Cardoso, Valbert Nascimento; de Andrade, Antero Silva Ribeiro

2014-04-15

275

Security Evolution.  

ERIC Educational Resources Information Center

Examines how to evaluate school security, begin making schools safe, secure schools without turning them into fortresses, and secure schools easily and affordably; the evolution of security systems into information technology systems; using schools' high-speed network lines; how one specific security system was developed; pros and cons of the…

De Patta, Joe

2003-01-01

276

Art & Evolution  

ERIC Educational Resources Information Center

In this article, the author presents a two-week evolution unit for his biology class. He uses Maria Sybilla Merian (1647-1717) as an example of an Enlightenment mind at work--in this case a woman recognized as one of the great artists and natural scientists of her time. Her representations of butterflies, caterpillars and their pupae, and the…

Terry, Mark

2005-01-01

277

Evaluation of serum CA15-3 determination with CEA and TPA in the post-operative follow-up of breast cancer patients.  

PubMed Central

The usefulness of post-operatively serial serum CA15-3 determination with CEA and TPA was evaluated in a group of 285 breast cancer patients. In particular, the CA15-3 sensitivity to 'early' diagnosis and monitoring of the response to treatment of breast cancer relapses, was compared with those of the two other markers in order to define the most suitable association. Moreover, in a group of 169 non relapsed patients with a prolonged follow-up (40 +/- 8 months; mean +/- s.d.) CA15-3 specificity was investigated. During post-operative follow-up in 27 (10%) patients, distant metastases occurred. In most of them, elevated values of one or more tumour markers were the first pathological sign and CA15-3, CEA and TPA sensitivity to 'early' diagnosis of metastases were 46%, 7% and 63% respectively. When each tumour marker was considered in combination, CA15-3-CEA-TPA association showed a higher sensitivity (87%) than both CA15-3-TPA (83%) and the CEA-TPA (70%). Serum CA15-3 increase preceded the certain sign of metastases 2.7 +/- 2.6 months (mean +/- s.d.). Shortly before appearance and during treatment of distant metastases, constant elevation and/or progressive increase in serum CA15-3 values occurred in all evaluated patients except three in whom isolated elevated values were found as well. In 24 (14%) of 169 non relapsed patients with prolonged follow-up (40 +/- 8 months; mean +/- s.d.) high serum CA15-3 values occurred. In 16 of these 24 patients, an isolated elevated value was found, while four (2.3%) or the eight remaining ones with constant elevation and/or progressive increase were falsely suspected of metastases. In this group of non relapsed patients, chronic liver failure, diabetes and/or hepatic steatosis were the reasons more commonly responsible for the CA15-3 increase. In metastatic patients, no organ-specificity was shown either by CA15-3 or by CEA and TPA. In these patients serum TPA values showed the highest sensitivity and paralleled clinical and/or instrumental signs better than the CA15-3 and even more than CEA values. These data indicate that in the post-operative follow-up of breast cancer patients, TPA is the most useful tumour marker and TPA-CA15-3 the most suitable association. Contemporaneous measurement of serum CEA levels only slightly increases sensitivity and positive predictive value of TPA-CA15-3 combination.

Nicolini, A.; Colombini, C.; Luciani, L.; Carpi, A.; Giuliani, L.

1991-01-01

278

Using maximum likelihood method to detect adaptive evolution of HCV envelope protein-coding genes  

Microsoft Academic Search

Nonsynonymous-synonymous substitution rate ratio (d\\u000a \\u000a N\\u000a \\/d\\u000a \\u000a S\\u000a ) is an important measure for evaluating selective pressure based on the protein-coding sequences. Maximum likelihood (ML)\\u000a method with codon-substitution models is a powerful statistic tool for detecting amino acid sites under positive selection\\u000a and adaptive evolution. We analyzed the hepatitis C virus (HCV) envelope protein-coding sequences from 18 general geno\\/subtypes\\u000a worldwide,

Wenjuan Zhang; Yuan Zhang; Yang Zhong

2006-01-01

279

Les qualités psychométriques de la version canadienne–française du Questionnaire de Satisfaction du Consommateur de services psychothérapeutiques (QSC–8 et QSC–18B)  

Microsoft Academic Search

L'objectif principal de la présente recherche est d'examiner les qualités psychométriques de la version Canadienne–Française du questionnaire de satisfaction du consommateur de services psychothérapeutiques (QSC). II s'agit, plus spécifiquement, d'évaluer la cohérence interne, la structure factorielle, et la validité concomitante du QSC. L'échantillon se compose de 126 clients du Service de psychologie de l'Université de Montréal qui ont complété une

STÉPHANE SABOURIN; DIANE PÉRUSSE; PIERRE GENDREAU

1989-01-01

280

Altérations environnementales du développement du testicule foetal: zoom sur les phtalates  

Microsoft Academic Search

Résumé  L’augmentation de plusieurs anomalies de la fonction de reproduction masculine suscite de grandes inquiétudes. Au cours des\\u000a quatre dernières décennies, le nombre de spermatozoïdes chez l’homme a nettement diminué, et l’incidence du cancer testiculaire\\u000a a doublé. De plus, les cas de cryptorchidie et d’hypospadias sont également en augmentation. L’hypothèse la plus couramment\\u000a admise est que tous ces effets néfastes sur

R. Habert; V. Muczynski; A. Lehraiki; D. Moison; R. Lambrot; C. Levacher; C. Lécureuil; R. Frydman; V. Rouiller-Fabre

2011-01-01

281

Changements climatiques récents et modification du régime hydrologique du fleuve Niger à Koulikoro (Mali)  

Microsoft Academic Search

Résumé Depuis une vingtaine d'années, le bassin du fleuve Niger et ceux des principaux cours d'eau africains sont soumis à un déficit pluvio- métrique important. La chronique des débits enregistrés à Koulikoro (120 000 km2) montre une décroissance persistante des écoulements. Cependant la baisse des pluies n'est que de 20% en valeur moyenne décennale entre 1951\\/1960 et 1981\\/1989, alors que

J. P. BRIQUET; G. MAHE; F. BAMBA; J. C. OLIVRY

282

Politiques de réduction des coûts du camionnage en Afrique sub-saharienne. Cas du Mali  

Microsoft Academic Search

Le présent rapport sur le Mali est divisé en cinq chapitres :Le premier chapitre fournit un éclairage sur le contexte économique, sociale et réglementaire dans le cadre duquel sont étudiés les coûts du transport routier.Le second chapitre analyse les pratiques de gestion des transporteurs ainsi que les comportements économico-financiers et les stratégies différenciées des artisans et des sociétés de transport.L'analyse

Dominique Bouf; Xavier Godard; Basile Keita; Olivier Klein

1989-01-01

283

Understanding Evolution for Teachers  

NSDL National Science Digital Library

This website was designed to teach evolution to teachers and explain common misconceptions, while providing guidance and tools for teaching evolution in the classroom and avoiding some of the pitfalls of the evolution "debate." Topics include the history if evolution, the evidence for evolution, evolution in the news, and lesson plans and conceptual frameworks that can be used by educators.

Paleontology, University O.

284

Genetics Home Reference: Cri-du-chat syndrome  

MedlinePLUS

... people of all ethnic backgrounds. What are the genetic changes related to cri-du-chat syndrome? Cri- ... Center . Where can I find general information about genetic conditions? The Handbook provides basic information about genetics ...

285

1. Historic American Buildings Survey, drawn by Pierre du Simitiere ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, drawn by Pierre du Simitiere (papers in Philadelphia Library) DRAWING OF REDWOOD LIBRARY IN 1768. - Redwood Library, 50 Bellevue Avenue, Newport, Newport County, RI

286

The Career Development Program at Du Pont's Pioneering Research Laboratory.  

ERIC Educational Resources Information Center

Describes the Career Development Program, designed to help professional employees accept responsibility for their own careers, located at Du Pont's Pioneering Research Laboratory. Covers the concepts governing the program, program elements, and working with management to address program goals. (CH)

Nusbaum, H. J.

1986-01-01

287

5. View north through Alfred I. Du Pont Insitute gates ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

5. View north through Alfred I. Du Pont Insitute gates to junction of Rockland Road and Old Murphy Road, George Murphy House to right - George Murphy House, Junction of Rockland & Old Murphy Roads, Wilmington, New Castle County, DE

288

Kyste ?pidermo?de du testicule : ?tude de cas  

PubMed Central

Résumé Le kyste épidermoïde (KE) du testicule est une tumeur bénigne rare. Le diagnostic peut être évoqué par l’échographie et l’IRM. En cas de lésion unique de petite taille, il est possible d’effectuer une chirurgie conservatrice. Ce traitement nécessite une confirmation anatomopathologique. Le présent article fait état de l’observation d’un patient de 34 ans ayant été admis en consultation d’urologie pour désir d’enfant. Le diagnostic de KE associé à une varicocèle gauche a été retenu. L’énucléation du kyste avec cure de varicocèle a été réalisée sans complications postopératoires. Une revue de la littérature nous a permis de mettre en évidence les différents aspects du KE du testicule et les méthodes thérapeutiques envisageables.

Diarra, Alkadri; Elammari, Jalal Eddine; Kassogue, Amadou; El Fassi, Mohammed Jamal; Farih, My Hassan

2013-01-01

289

La nutrition du nourrisson n? ? terme et en sant?  

PubMed Central

La nutrition du nourrisson né à terme et en santé constitue le nouvel énoncé national sur la nutrition du nourrisson, de la naissance à l’âge de 24 mois. Il s’agit d’un projet conjoint de la Société canadienne de pédiatrie, des Diététistes du Canada et de Santé Canada. Cet ouvrage est une synthèse de la documentation scientifique actuelle en matière de nutrition du nourrisson ; il contient des principes et recommandations afin d’aider les professionnels de la santé à promouvoir la prestation des meilleurs soins alimentaires possibles pour les nourrissons du Canada, compte tenu de l’état actuel de la recherche. La collaboration entre les trois principaux organismes qui s’intéressent à cette question a permis d’uniformisé le message que les professionnels transmettront au public. Le document aborde quatre grands sujets relatifs à la première année d’existence : l’allaitement, les laits de remplacement, les autres liquides dans le régime du nourrisson et la transition aux aliments solides. On y examine ensuite la question de la sécurité dans l’alimentation, puis celle de la nutrition durant la deuxième année. La dernière section couvre les autres questions liées à la nutrition du nourrisson ; on y traite de sujets tels que les allergies alimentaires, les coliques, la constipation, les matières grasses dans le régime alimentaire, la carie dentaire, la gastroentérite, le diabète, l’anémie ferriprive et les régimes végétariens. Le document contient également un répertoire complet de plus de 200 citations. Le sommaire des principes et recommandations paraîtra dans les revues officielles de la Société canadienne de pédiatrie (Paediatrics and Child Health, 1998) et des Diététistes du Canada (Revue canadienne de pratique et de recherche en diététique, juin 1998). On peut télécharger le document intégral à partir des sites Web respectifs des trois organismes associés ; on peut aussi obtenir la version imprimée de l’Énoncé, en français ou en anglais, auprès de la Société canadienne de pédiatrie, des Diététistes du Canada ou de Santé Canada. Avec La nutrition du nourrisson né à terme et en santé, les professionnels de la santé de toutes disciplines disposent d’un outil scientifique à la fine pointe pour conseiller les parents et exercer une influence positive sur l’environnement nutritionnel qui s’offre aux nourrissons du Canada.

1998-01-01

290

Évolution nycthémérale des composantes biochimiques du phytoplancton de la retenue du barrage Idriss premier (Fès, Maroc)  

NASA Astrophysics Data System (ADS)

The diel changes of the biochemical composition of the phytoplankton were studied in the Idriss first reservoir (located on the Inaouen river at thirty Km from the city of Fes, Morrocco) during September 1994. Several biomass and metabolic indicators (proteins, carbohydrates, lipids, chlorophyll a and primary production) were assessed every fourth hour over tow days (7, 8 and 9 September). Since the Protein/Carbohydrates ratio (P/C) is largely recognised as a good integrator of the metabolic functions of the cells, we examined its distribution pattern concomitantly with aforementioned parameters. The results demonstrated enhanced P/C ratios clearly indicating that nutrients were sufficiently available for growth. In addition, this index showed a diel significant variation with levels higher in the night than in the day. Moreover, these results suggest that phytoplankton species during the night used the day-synthesised carbohydrates to insure the cell metabolic functioning. The P/C presents relatively high values in proposition to the ones that have been recorded in temperate regions, and seems to be related to azotic inputs of the Inaouen river. Dans le but de parfaire nos connaissances sur le fonctionnement du sous écosystème phytoplancton, nous nous sommes intéressés à étudier son cycle nycthéméral et son métabolisme cellulaire dans la retenue du barrage Idriss premier. Cette dernière, construite sur l'Oued Inaouène, est située à une trentaine de Km de la ville de Fès. Au cours de ce cycle, les prélèvements ont été effectués selon une séquence temporelle de 4 heures pendant 48 heures, les 7, 8 et 9 septembre 1994. L'étude de l'évolution des composantes biochimiques des cellules phytoplanctoniques à savoir les protéines, les glucides et les lipides a permis de mettre en évidence des variations nycthémérales importantes. Ces variations sont d'autant plus importantes que les variations spatiales observées entre les profondeurs. De plus, le rapport protéines/glucides (P/G), reconnu comme un bon indicateur de l'état physiologique des algues, présente des valeurs plus élevées la nuit que le jour au niveau du fond du lac. Ce résultat suggère que le phytoplancton utilise les produits de réserve synthétisés le jour pour assurer le fonctionnement métabolique des cellules. De plus, les valeurs de ce rapport sont relativement élevées par rapport à celle enregistrées dans les régions tempérés et semblent être liées aux ressources azotées du milieu en particulier les apports de l'Oued Inaouène.

Bahhou, J.; Alaoui Mhamdi, M.

1999-03-01

291

Le traumatisme du colon: l'exp?rience du CHU Hassan II de F?s  

PubMed Central

Introduction Les traumatismes du colon sont associés à un risque majeur de complications septiques et de mortalité. Le but de notre étude est d’évaluer les circonstances, la prise en charge, le suivi et les facteurs pronostic de morbidité postopératoire des malades victimes d'un traumatisme colique. Méthodes Il s'agit d'une étude rétrospective sur une série de 49 patients opérés pour des plaies coliques aux services de chirurgie viscérale du CHU HASSAN II de Fès sur une période de 8 ans de juillet 2003 à juillet 2011. Résultats L’âge moyen de nos patients était de 25ans (16-70) avec une nette prédominance masculine (93.8%). Les plaies coliques secondaires à un traumatisme par arme blanche représentent 85% des cas (42 patients), suivi par les plaies iatrogènes au cours d'une coloscopie chez 6 patients (13%), puis les contusions abdominales chez 1 patient (2%). Les parties du cadre colique les plus touchées étaient le colon transverse chez 19 patients (38%) et le colon descendant chez 12 patients (24, 5%). Le colon sigmoïde était le segment le plus touché au cours d'une coloscopie4/6. Quarante-deux patients (85%) ont eu une suture primaire des plaies coliques, six patients (13%) une diversion fécale et un patient (2%) une résection-anastomose. Deux patients (4%) sont décédés suite à un choc septique. La morbidité globale était de 38,7% dominé essentiellement par l'infection de la paroi chez 14 patients et une péritonite post opératoire chez 3 patients. L'analyse univarié a montré une différence significatif en terme d'infection de la paroi entre le groupe colostomie versus suture simple (50% vs 20,9% p<0,05). L'atteinte du colon gauche et la réalisation d'une colostomie sont associés à un risque plus élevés de complications postopératoires. Conclusion La suture primaire peut être effectuée avec un faible taux de complications postopératoire chez la majorité des patients suite à un traumatisme du colon.

Benjelloun, El Bachir; Hafid, Hasnai; Karim, Ibnmajdoub; Ousadden, Abdelmalek; Mazaz, Khalid; Taleb, Kahlid Ait

2012-01-01

292

Isolation of a carcino-embryonic-antigen (CEA) from a liver metastasis of primary adenocarcinoma of the colon and preparation of the specific antiserum  

Microsoft Academic Search

Résumé Description d'une méthode de purification de l'antigène carcino-embryonnaire à partir de métastases hépatiques d'adéno-carcinomes primaires du côlon, méthode qui présente des avantages de rendement et d'application. Faite par une solution hypertonique de chlorure de potassium, l'extraction du produit préparé avec l'acide perchlorique est particulièrement intéressante. Ce procédé améliore considérablement la purification, sans nuire à la précision. On décrit également

A. P. Mistretta; A. Bartorelli; A. Golferini; G. C. Tassi; A. De Barbieri; R. Accinni

1974-01-01

293

Du Pont announces new recycling facility for plastic material  

SciTech Connect

Du Pont announced that is building a recycling facility for plastic material in Born, Limburg, the Netherlands. The plant will process polymer-based material from several Du Pont facilities in Europe to conserve raw materials and minimize the amount of plastic entering the solid waste stream. Investment in the facility, which is expected to be fully operational by October, will exceed $4 million. Initial capacity will be 12 million pounds per year.

Not Available

1989-10-01

294

Le Massif volcanique du Dalai-nor (Gobi Oriental)  

Microsoft Academic Search

\\u000a Conclusion  L’étude de la région volcanique du Dalai-nor , en établissant l’existence de vastes éruptions pliocènes el récentes au Sud\\u000a de la Mongolie , est susceptible de modifier sur plusieurs points les conceptions que les géologues se faisaient jusqu’ici\\u000a des basaltes de Chine. Ces basalles, largement répandus ta (à la manière des rhyolites mésozoïqurs) tout autour du haut Plateau\\u000a mongol, depuis

P. Teilhard de Chardin

1925-01-01

295

Cloning and sequencing of Duck circovirus (DuCV)  

Microsoft Academic Search

Summary. The genome of Duck circovirus (DuCV) is circular and 1996?nts in size. Two major open reading frames were identified, encoding the replicase (V1) and the capsid protein (C1). A stem-loop structure comprising the nonamer 5'-TATTATTAC, conserved in all circo-, nano- and geminiviruses, was found. Unique to DuCV, the region between the 3'-ends of the rep and cap gene contains

K. Hattermann; C. Schmitt; D. Soike; A. Mankertz

2003-01-01

296

Approche cognitive du pilotage stratégique de l'entreprise agricole  

Microsoft Academic Search

[fre] Le domaine du pilotage stratégique, et en particulier celui des décisions d'équipement, est au cœur des préoccupations actuelles du conseil pour l'entreprise agricole. On se propose ici de montrer l'intérêt d'une approche cognitive des décisions d'équipement en grande culture : on entend par là une approche qui vise à comprendre pourquoi et comment les acteurs prennent leurs décisions. On

Sophie Allain

1999-01-01

297

Réduction du temps de travail. Organisation et conditions de travail  

Microsoft Academic Search

[fre] Cette note met en évidence qu'une réduction massive de la durée du travail (RTT) n'implique pas nécessairement une amélioration des conditions de travail. Les premiers accords Robien puis Aubry confirment les risques de densification, d'intensification du travail ou de flexibilité accrue alors que les salaires sont préservés. Un modèle de négociation paritaire sur les salaires et les conditions de

Philippe Askenazy

2000-01-01

298

Résistance du consommateur : vers une clarification des concepts  

Microsoft Academic Search

Le propos de ce papier est de clarifier, sur un plan sémantique, ce qu'est la résistance du consommateur selon une vision micro-individuelle. Pour cela, il utilise la linguistique pour extraire d'un corpus de définitions propres à chaque discipline les éléments de sens devant servir d'ingrédients à une définition utilisable dans le champ de la recherche expérimentale en comportement du consommateur.

Jean-Claude Dandouau

2010-01-01

299

Determination of periodontopathogens in patients with Cri du chat syndrome  

PubMed Central

Objectives: Cri du chat syndrome is a genetic alteration associated with some oral pathologies. However, it has not been described previously any clinical relationship between the periodontal disease and the syndrome. The purpose of this comparative study was to compare periodontopathogenic flora in a group with Cri du chat syndrome and another without the síndrome, to assess a potential microbiological predisposition to suffer a periodontitis. Study Design: The study compared nineteen subjects with Cri du chat Syndrome with a control group of nineteen patients without it. All patients were clinically evaluated by periodontal probing, valuing the pocket depth, the clinical attachmente level and bleeding on probing. There were no significant differences between both groups. Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Tannerella forsythia and Treponema denticola were detected by multiplex-PCR using 16S rDNA (microIDENT). Results: When A. actinomycetemcomitans, P. gingivalis, P. intermedia and T. denticola were compared, no statistically significant differences were found between the two groups (p>0.05). The value of T. forsythia was significantly higher for Cri du chat syndrome (31.6%) than for the control group (5.3%). The odds ratio for T. forsythia was 8.3. Conclusions: In the present study T. forsythia is associated with Cri du chat syndrome subjects and not with healthy subjects. Key words:Cri du Chat syndrome, periodontal health, microbiology, special care dentistry.

Ballesta-Mudarra, Sofia; Torres-Lagares, Daniel; Rodriguez-Caballero, Angela; Yanez-Vico, Rosa M.; Solano-Reina, Enrique; Perea-Perez, Evelio

2013-01-01

300

Effets du titane et du niobium sur l'oxydation à 950circC d'aciers ferritiques  

NASA Astrophysics Data System (ADS)

Nous avons étudié l'effet du titane et du niobium sur l'oxydation à 950circC d'un acier Fe-Cr chrominoformeur. La DRX in situ montre que le titane semble s'oxyder en formant Cr{2}TiO{5} et TiO{2} qui contribuent à une augmentation de la prise de masse des échantillons. Une partie du titane issu de ces oxydes semble doper la couche de chromine. Sa présence augmente la concentration en lacunes cationiques dans la chromine et augmente donc la diffusion du chrome dans la couche. Nous avons aussi montré que le niobium n'a pas d'influence sur l'oxydation de ce type d'acier à 950circC.

Issartel, C.; Buscail, H.; Caudron, E.; Cueff, R.; Riffard, F.; El Messki, S.; Karimi, N.; Antoni, L.

2004-11-01

301

Etude expérimentale IN VITRO du comportement rhéologique du sang en régime transitoire à faible vitesse de cisaillement  

Microsoft Academic Search

Résumé Des écoulements de type Couette en régime transitoire sont produits au moyen d'un microviscosimètre semi-automatique à cylindres coaxiaux muni d'un asservissement de la vitesse de rotation et d'un enregistreur à deux voies, et qui peut être associé à un générateur de fonction basse fréquence permettant de programmer la vitesse de rotation du cylindre extérieur du viscosimètre. Diverses sortes de

M. Bureau; J. C. Healy; D. Bourgoin; M. Joly

1978-01-01

302

Sensitivity and specificity of CA242 in gastro-intestinal cancer. A comparison with CEA, CA50 and CA 19-9.  

PubMed Central

A serological assay for the quantitative determination of the novel tumour-associated epitope CA242 was developed and used for determination of sensitivity and specificity of CA242 in gastrointestinal cancer. The CA242 assay showed a better tumour specificity than CA50 (and CA 19-9). This was most noticeable in benign hepatobiliary disease. The sensitivity at 90% specificity cut-off level was approximately three times higher for CA242 compared to CA50 in colo-rectal cancer Dukes A, B and C, while in pancreatic cancer the sensitivity of CA242 and CA50 was similar. CA242 was expressed independently of CEA, and the combination of CEA and CA242 gave in colo-rectal cancer considerably higher sensitivity than the use of only one of the markers. This was most pronounced in Dukes A and Dukes B patients. CA242 is a novel tumour marker of potential clinical use, particularly in colo-rectal cancer.

Nilsson, O.; Johansson, C.; Glimelius, B.; Persson, B.; N?rgaard-Pedersen, B.; Andren-Sandberg, A.; Lindholm, L.

1992-01-01

303

Evaluation of the CEAS trend and monthly weather data models for soybean yields in Iowa, Illinois, and Indiana  

NASA Technical Reports Server (NTRS)

The CEAS models evaluated use historic trend and meteorological and agroclimatic variables to forecast soybean yields in Iowa, Illinois, and Indiana. Indicators of yield reliability and current measures of modeled yield reliability were obtained from bootstrap tests on the end of season models. Indicators of yield reliability show that the state models are consistently better than the crop reporting district (CRD) models. One CRD model is especially poor. At the state level, the bias of each model is less than one half quintal/hectare. The standard deviation is between one and two quintals/hectare. The models are adequate in terms of coverage and are to a certain extent consistent with scientific knowledge. Timely yield estimates can be made during the growing season using truncated models. The models are easy to understand and use and are not costly to operate. Other than the specification of values used to determine evapotranspiration, the models are objective. Because the method of variable selection used in the model development is adequately documented, no evaluation can be made of the objectivity and cost of redevelopment of the model.

French, V. (principal investigator)

1982-01-01

304

Value of radioimmunoscintigraphy with technetium-99m labelled anti-CEA monoclonal antibody (BW431\\/26) in the detection of colorectal cancer  

Microsoft Academic Search

This study was undertaken as part of a Coordinated Research Programme initiated by the International Atomic Energy Agency to evaluate the usefulness of radioimmunoscintigraphy (RIS) in the management of patients with colorectal cancer. Technetium-99m labelled BW431\\/26, a monoclonal antibody against carcino-embryonic antigen (CEA), was used. The study included 73 patients (31 females and 42 males). Sixty-eight patients were suspected of

Makumkrong Poshyachinda; Tawatchai Chaiwatanarat; Nui Saesow; Suree Thitathan; Narin Voravud

1996-01-01

305

Nicotine dependence produces hyperalgesia: role of corticotropin-releasing factor-1 receptors (CRF1Rs) in the central amygdala (CeA).  

PubMed

Because tobacco use has a large negative health and financial impact on society, it is critical to identify the factors that drive excessive use. These factors include the aversive withdrawal symptoms that manifest upon cessation of tobacco use, and may include increases in nociceptive processing. Corticotropin-releasing factor (CRF) signalling in the central amygdala (CeA) has been attributed an important role in: (1) central processing of pain, (2) excessive nicotine use that results in nicotine dependence, and (3) in mediating the aversive symptoms that manifest following cessation of tobacco exposure. Here, we describe three experiments in which the main hypothesis was that CRF/CRF1 receptor (CRF1R) signalling in the CeA mediates nicotine withdrawal-induced increases in nociceptive sensitivity in rats that are dependent on nicotine. In Experiment 1, nicotine-dependent rats withdrawn from chronic intermittent (14-h/day) nicotine vapor exhibited decreased hind paw withdrawal latencies in response to a painful thermal stimulus in the Hargreaves test, and this effect was attenuated by systemic administration of the CRF1R antagonist, R121919. In Experiment 2, nicotine-dependent rats withdrawn from nicotine vapor exhibited robust increases in mRNA for CRF and CRF1Rs in CeA. In Experiment 3, intra-CeA administration of R121919 reduced thermal nociception only in nicotine-dependent rats. Collectively, these results suggest that nicotine dependence increases CRF/CRF1R signalling in the CeA that mediates withdrawal-induced increases in sensitivity to a painful stimulus. Future studies will build on these findings by exploring the hypothesis that nicotine withdrawal-induced reduction in pain thresholds drive excessive nicotine use via CRF/CRF1R signalling pathways. PMID:24107576

Baiamonte, Brandon A; Valenza, Marta; Roltsch, Emily A; Whitaker, Annie M; Baynes, Brittni B; Sabino, Valentina; Gilpin, Nicholas W

2014-02-01

306

Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis  

Microsoft Academic Search

BACKGROUND: Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF), serum CEA levels, and EGFR and HER2 tissue-expression in brain metastasis (BM) and overall survival (OS) in patients with advanced NSCLC. METHODS: In a

Oscar Arrieta; David Saavedra-Perez; Roberto Kuri; Alejandro Aviles-Salas; Luis Martinez; Daniel Mendoza-Posada; Patricia Castillo; Alma Astorga; Enrique Guzman; Jaime De la Garza

2009-01-01

307

Evaluation of serum CA15-3 determination with CEA and TPA in the post-operative follow-up of breast cancer patients  

Microsoft Academic Search

The usefulness of post-operatively serial serum CA15-3 determination with CEA and TPA was evaluated in a group of 285 breast cancer patients. In particular, the CA15-3 sensitivity to 'early' diagnosis and monitoring of the response to treatment of breast cancer relapses, was compared with those of the two other markers in order to define the most suitable association. Moreover, in

A Nicolini; C Colombini; L Luciani; A Carpi; L Giuliani

1991-01-01

308

Expression of the insulin-like growth factor-II mRNA-binding protein 3 (IMP3) and carcinoembryonic antigen (CEA) in mucinous minimal deviation adenocarcinoma.  

PubMed

Mucinous minimal deviation adenocarcinoma (MDA) is a rare highly differentiated mucinous adenocarcinoma of the uterine cervix, which always remains a diagnostic dilemma. Lobular endocervical glandular hyperplasia (LEGH), a rare benign lesion of the uterine cervix, is identified as precursor of mucinous MDA. The insulin-like growth factor-II mRNA-binding protein 3 (IMP3) is expressed in a number of cancers and is associated with progression of the tumors. The purpose of this study was to evaluate the expression of the IMP3, carcinoembryonic antigen (CEA), and cyclin-dependent kinase inhibitor p16(INK4a) in mucinous MDA and LEGH, and to estimate the possible role of these biomarkers in the diagnosis of mucinous MDA. Twelve samples of MDA, eight samples of lobular endocervical glandular hyperplasia (LEGH), and 20 normal control cases were included in this study. Typical lesions and less well-differentiated lesions coexisted in 11/12 mucinous MDA samples. Positive cytoplasmic expression for IMP3 and CEA was found in less well-differentiated lesions of all 11 mucinous MDA samples, primarily with strong to intermediate staining intensity. The typical well-differentiated lesions of all 12 MDA cases and 8 cases of LEGH showed negativity for both IMP3 and CEA. No exact p16(INK4a) positivity was observed in 12 mucinous MDA and 8 LEGH. The significant expression of IMP3 and CEA in less well-differentiated foci of mucinous MDA may be helpful in the diagnosis of mucinous MDA to some extent, particularly in small specimens from cervical biopsy. More cases and in-depth researches are needed to elucidate the potential different mechanisms between typical and less well-differentiated lesions of mucinous MDA. PMID:21497449

He, Ying; Li, Lei; Jiang, Wei; Wang, Dan-qing; Xu, Lian; Huang, Qin; Zhang, Yan; Yang, Kai-xuan

2011-05-15

309

The role of two enzymes (LDH and PHI) and a tumour marker (CEA) in the prognostic evalution of head and neck malignancy.  

PubMed

A study of 30 patients with biopsy proven carcinoma of head and neck were taken and serum levels of CEA, LDH and PHI was estimated before treatment and 3 months post treatment. 30 patients were taken as controls for comparison. Pre- and past-treatment levels were statistically compared and the role of surgery, radiotherapy and chemotherapy compared. Variation with metastasis and with smoking was also evaluated. PMID:23119762

Narang, A P; Greval, R S; Chopra, H; Kalra, C S

2001-01-01

310

Effect of coenzyme Q10, riboflavin and niacin on serum CEA and CA 15-3 levels in breast cancer patients undergoing tamoxifen therapy.  

PubMed

In breast cancer patients, it is not the primary tumour, but its metastases at distant sites that are the main cause of death. Circulating breast cancer tumour markers such as carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA 15-3) are reliable indicators of impending relapse, in which an increasing tumour marker level is associated with a very likelihood of developing recurrence. In the present study, 84 breast cancer patients were randomized to receive a daily supplement of 100 mg coenzyme Q10 (CoQ10), 10 mg riboflavin and 50 mg niacin (CoRN) one dosage per day along with 10 mg tamoxifen (TAM) twice a day. Serum CEA and CA 15-3 levels were elevated in untreated breast cancer patients (group II) and their tumour marker levels significantly reduced upon tamoxifen therapy for more than 1 year (group III). Group III patients supplemented with CoRN for 45 d (group IV) and 90 d (group V) along with tamoxifen significantly reduced CEA and CA 15-3 levels. This study suggests supplementing CoRN to breast cancer patients along with tamoxifen reduces the serum tumour marker level and thereby reduce the risk of cancer recurrence and metastases. PMID:17268082

Premkumar, Vummidi Giridhar; Yuvaraj, Srinivasan; Vijayasarathy, Kothandaraman; Gangadaran, Sitthu Govindaswamy Dinakaran; Sachdanandam, Panchanatham

2007-02-01

311

Thermode´sorption et photode´sorption du potassium adsorbe´sur du cuivre  

Microsoft Academic Search

La thermode´sorption et la photode´sorption onte´te´e´tudie´es pour des dépoˆts de potassium sur une face (100) du cuivre. Pour des dépoˆts voisins de 1 monocouche ou plus denses, la thermode´sorption est conformea`un mode`le de processus active´et la photode´sorption a un rendement quantique voisin de 10-7 atome\\/photon. Pour des dépoˆts moins denses les phénome`nes sont plus complexes et il apparaiˆt des effets

Y. de Ribaupierre

1973-01-01

312

Tumor growth suppression by a mouse/human chimeric anti-CEA antibody and lymphokine-activated killer cells in vitro and in SCID mouse xenograft model.  

PubMed

The mouse/human chimeric antibody Ch F11-39, recently generated by ourselves, shows the same high specificity and affinity for carcinoembryonic antigen (CEA) as those of its parental mouse monoclonal antibody. Ch F11-39 is capable of mediating antibody-dependent cell-mediated cytotoxicity (ADCC) with human peripheral blood lymphocytes (PBL). Interleukin-2 (IL-2) modulates the function of immunocytes, in particular inducing lymphokine-activated killer (LAK) cells and enhancing ADCC. In the present study, we therefore tested the combination immunotherapy of Ch F11-39 with LAK cells in vitro and in severe combined immunodeficiency (SCID) mice bearing human CEA-producing tumors. In vitro experiments using human gastric tumor cell lines, Ch F11-39 effectively mediated ADCC against CEA-positive MKN-45 cells, but not against CEA-negative cells. The specificity of ADCC for Ch F11-39 was demonstrated by experiments with irrelevant target cells or irrelevant antibody. ADCC activity of PBL with Ch F11-39 was enhanced by double after preincubation with IL-2 at 10 U/ml. The concentration of Ch F11-39 required for 50% maximal cell killing was about 0.25 microgram/ml at 10 U/ml of IL-2. Increasing ADCC was triggered by IL-2 earlier (1 day) than the generation of LAK cells (3 days). Control human IgG blocked the ADCC, suggesting that the enhancement of ADCC by IL-2 may be caused by activation of effector cells expressing Fc receptors. In vivo anti-tumor activity of combined immunotherapy was estimated using SCID mice inoculated s.c. with 1 x 10(7) MKN-45 cells. The i.v. administration of LAK cells and i.p. administration of Ch F11-39 and IL-2 produced a marked growth inhibition of MKN-45 tumors in SCID mice (about 50% reduction in tumor size as compared to the control untreated group, measured 15 days after treatment). In summary, the enhanced antitumor activity of Ch F11-39 with LAK cells suggests that it might be a useful immunotherapeutic reagent for CEA-expressing tumors. PMID:9568050

Senba, T; Kuroki, M; Arakawa, F; Yamamoto, T; Kuwahara, M; Haruno, M; Ikeda, S; Matsuoka, Y

1998-01-01

313

Evolution of Digital Organisms  

NSDL National Science Digital Library

Students are introduced to the concepts of digital organisms and digital evolution. They learn about the research that digital evolution software makes possible, and compare and contrast it with biological evolution.

Bio-Inspired Technology and Systems (BITS) RET,

314

Innovation, imitation et rattrapage en présence de rigidités sur le marché du travail  

Microsoft Academic Search

[fre] Innovation, imitation et rattrapage en présence de rigidités sur le marché du travail. . On étudie, dans un cadre théorique majorant les effets de la concurrence des pays à bas salaires, les justifications et l'impact prévisible de l'accord portant sur la propriété intellectuelle signé dans le cadre du GATT. Le Nord, au marché du travail non qualifié rigidifié par

Jean-Louis Guérin

1997-01-01

315

Pension benefits for Du Pont employees at the Savannah River Plant  

SciTech Connect

The purpose of the audit was to evaluate issues concerning the E. I. du Pont de Nemours and Company (Du Pont) pension benefits settlement upon expiration of its contract with the Department of Energy (Department), at which time the Department is obligated to ensure that Du Pont retirees receive their pensions over the ensuing years. The contract expires on March 31, 1989.

Not Available

1989-02-24

316

M.I.C.E. - NOUVEL ENJEU POUR LE DÉVELOPPEMENT DU TOURISME AU VIETNAM ?  

Microsoft Academic Search

Le Tourisme du Vietnam se développe et tente de s'intégrer au réseau régional et mondial. La concurrence devient de plus en plus serrée, et il faut répondre aux diverses demandes du marché. Ainsi apparait une nouvelle formule: le MICE. La définition de ce secteur, l'analyse SWOT du tourisme vietnamien, les expériences des autres pays apporteront au Vietnam un regard détaillé

VO SANG; Xuan Lan

317

Vissage percutan? du scapho?de carpien par vis de Herbert - ? propos de 10 cas  

PubMed Central

Les fractures du scaphoïde carpien sont de diagnostic et de traitement difficiles. Les auteurs rapportent les résultats du traitement de ces fractures par le vissage percutané par la vis de Herbert. Les résultats étaient intéressants vu la rapidité de consolidation et la qualité du résultat fonctionnel.

Abbassi, Najib; Abdeljawad, Najib; Erraji, Moncef; Abdelillah, Rachid; Daoudi, Abdelkrim; Yacoubi, Hicham

2013-01-01

318

Effets du vieillisement de la batterie Li-ion sur les performances d'un vehicule recreatif hybride branchable a trois roues  

NASA Astrophysics Data System (ADS)

La prediction de l'evolution du vieillissement de la batterie lithium-ion est source d'un grand defi, dans les applications liees aux vehicules electriques et hybrides. Sa meconnaissance est un risque considerable compromettant la viabilite d'un tel systeme. Invoquant les couts substantiels de la densite d'energie, liee a la degradation considerable des performances de la batterie au cours de sa duree de vie, il devient important d'en tenir compte des le processus de conception. La dependance de la strategie de controle du vehicule aux parametres de la batterie justifie aussi la necessite d'une telle prediction. Il est connu que le vieillissement, sensible aux facteurs tels que le courant, la temperature et la profondeur de decharge, a un impact considerable sur la perte de capacite de la batterie ainsi que sur l'augmentation de la resistance interne. Le premier est directement lie a l'autonomie electrique du vehicule, alors que le second mene a une surchauffe de la batterie, a une augmentation des pertes en puissance qui se manifeste par une diminution de la tension de bus. A cet egard, implique dans la conception d'un vehicule recreatif hybride branchable a trois roues, le Centre de Technologies Avancees s'interesse a l'etude du vieillissement de la batterie Li-ion pour une telle application. Pour ce faire, au contraire de la plupart des estimations empiriques de la duree de vie, basees sur des profils de decharge a courant constant, un profil de courant plus approprie pour l'application donnee, base sur un cycle de vitesse representatif de la conduite d'une motocyclette, a ete utilise. Par le biais d'un simulateur complet du vehicule, le cycle de courant a ete extrait du cycle de vitesse. Ainsi, les travaux menes impliquent l'analyse experimentale de la decharge cyclique de quatre cellules LiFePO 4. Pendant plus de 1400 cycles, un banc d'essai complet a permis l'acquisition de la capacite, de la resistance interne, du courant, de la tension ainsi que de la temperature de surface. Mots-cles : vieillissement, batterie, lithium-ion, LiFePO4, capacite, resistance interne, PHEV, vehicule

Nadeau, Jonathan

319

Immunoassay for CEA using the novel probe-labeled Ag nanoparticles based on surface-enhanced Raman scattering  

NASA Astrophysics Data System (ADS)

In this study, we report the Ag nanoparticles aggregated in the process of the labeling that use the crystal violet as the Raman probe. After this process- immune nanoparticles aggregate with high SERS sensitivity and biological specificity are created. We track and characterize the preparation by employing UV-Vi absorption spectra, Transmission Electron Microscope (TEM) and SERS spectra. With the increase of crystal violet, the aggregate of the Ag nanoparticles also increase, while the intensity of absorption peaks decrease. When the concentration of crystal violet reaches 1.0×10-4 mol/L, new peaks were found in the long wavelengths, and with the increase of the crystal violet, the intensity of the new peaks increase as well. We observe from the TEM, that with the increase of crystal violet, the aggregation degree of the Ag nanoparticles also increase and then they unite together. The SERS activity of the aggregates was directly related to the aggregation degree. Detecting the SERS activity of Ag NPs aggregates labeled with different amount of crystal violet, we found that with the increase of the crystal violet, the SERS signals of NPs aggregates enhanced. However, when the amount of crystal violet exceeded 25?L in 1mL colloidal silver, the Ag NPs occurred agglomeration and thereafter the next preparation of immune-label aggregates was hindered. Whereas, the probe labelled with 12?L crystal violet exhibited a better stability, stronger SERS activity and higher biological specificity, and it may accomplish a highly efficient SERS-based immunoassay. This immune probe was applied for detecting the expression of carcinoembryonic antigen (CEA) in the colon cancer tissue slice. Results show that appropriate immune aggregates labelled with optimum quantity of crystal violet present high stability, strong SERS activity and good immune specificity, which are expected to be applied in the analysis of the protein expression in the tissue section and promising for developing into a clinical tool for diagnosis.

Lin, Xiaoqian; Xi, Gangqin; Chen, Yanping; Chen, Gang; Zheng, Xiongwei; Lei, Jinping; Ou, Lin; Feng, Shangyuan; Zeng, Haishan; Chen, Rong; Sun, Liqing

2011-11-01

320

Le marché du travail urbain en Thaïlande est-il segmenté ? Analyse à l'aide d'un modèle à changement de régime endogène avec règle de séparation inconnue  

Microsoft Academic Search

Cet article tente d’évaluer un aspect spécifique du marché du travail urbain en Thaïlande en se basant sur la théorie du marché du travail segmenté. Le débat actuel sur la pauvreté et la persistance de l’inégalité est relié aux théories dominantes du capital humain et de la segmentation du marché du travail. Contrairement aux prédictions faites par la théorie néoclassique,

Kumlaï Jongkong

2007-01-01

321

Modelisation DU Signal Radar EN Milieu Stratifie et Evaluation de Techniques de Mesure de L'humidite DU Sol  

NASA Astrophysics Data System (ADS)

La presente etude se penche sur des problemes relies a l'echantillonnage de l'humidite de sol et a l'estimation du signal radar sur sols nus. Le travail se divise en deux volets. Le volet 1 evalue trois techniques de mesure de l'humidite du sol (gravimetrie, reflectometrie temporelle et sonde dielectrique) et deux protocoles d'echantillonnage. Dans le volet 2, un modele de simulation du signal en milieu stratifie est developpe, et les estimes de signal obtenus sont compares aux estimes bases uniquement sur une valeur moyenne d'humidite du sol prise sur une profondeur fixe d'echantillonnage. Les differences entre les deux estimes dependent de la frequence et du choix judicieux de la profondeur d'echantillonnage; elles sont plus importantes aux faibles angles et en polarisation HV, puis VV. Le modele de simulation a aussi ete utilise pour etudier la profondeur de penetration du signal et en deduire la profondeur optimale d'echantillonnage en tenant compte des caracteristiques du signal. Une variation de 25 ^circ de l'angle d'incidence a peu d'effet sur la profondeur de penetration en bande Ku; l'ecart reste inferieur ou egal a 0,5 cm en bande C mais peut atteindre 1,3 cm en bande L. L'impact de la polarisation est nul en bande Ku mais croi t avec l'angle d'incidence en bande C et L. A 50^circ, il est, en moyenne de 1 cm en bande C et de 2 cm en bande L. En polarisation VV, la profondeur croi t avec une augmentation de l'angle alors que l'effet est inverse en polarisation HH. Deux methodes pour estimer la profondeur d'echantillonnage en conditions operationnelles sont presentees. Lorsqu'on inverse un modele pour estimer l'humidite du sol a partir du signal, ces methodes permettent aussi d'estimer l'epaisseur de sol representee par l'humidite ainsi estimee.

Boisvert, Johanne

322

Les rivie?res et les sources de la Plaine du Cul-de-Sac: extrait du rapport sur les eaux souterraines de la Plaine du Cul-de-Sac  

USGS Publications Warehouse

Les principales rivières de la Plaine du Cul-de-Sac, la Rivière Grise ou Grande Rivière du Cul-de-Sac et la Rivière Blanche, prennent naissance sur le flanc Nord du Massif de la Selle à des altitudes de 1,300 à 1,800 mètres au dessus du niveau de la mer. Elles coulent à l’amont à travers des gorges profondes et sont éloignées de 9 Kms. dans la partie central de la bordure Sud de la plaine.

Taylor, George C., Jr.; Lemoine, Rémy C.

1949-01-01

323

Chicago's Jean Baptiste Point Du Sable High School  

NSDL National Science Digital Library

Chicago's Jean Baptiste Point Du Sable High School is an ongoing exploration of how integration of the Internet into day-to-day school activities can affect education in an inner-city school. It is a training site for the entire Chicago Public School system and is one of 14 demonstration sites chosen by the State of Illinois for implementation of technology into education. The proposal for technology implementation that Du Sable submitted to the Illinois State Board of Education is available on the site, and may be of assistance to other inner-city schools writing similar proposals. The site also contains an excellent pointers page for resources on the Internet, and resources to help "get your school on the net." http://www.dusable.cps.k12.il.us/ Du Sable's technology implementation proposal: http://www.dusable.cps.k12.il.us/narr_ToC.html

324

Le cancer en Mauritanie : r?sultats sur 10 ans du registre hospitalier de Nouakchott  

PubMed Central

Le fardeau du cancer reste mal connu en Mauritanie. Il n'est basé que sur des extrapolations de l'incidence des cancers des pays avoisinants. Les données du registre de l'hôpital national permettent de décrire les cas avec un diagnostic histologique. Tous les cas de cancers enregistrés par le service d'anatomo-pathologie de l'hôpital national de Nouakchott de 2000 à 2009 ont été analysés. En 10 ans, 3305 prélèvements histologiques ont été analysés (hommes:42%, femmes:58%). Chez l'homme, le cancer le plus fréquemment analysé était le cancer de la peau (218 cas au total, 189 cas en excluant mélanome), suivi de la prostate (203), des cancers digestifs (179, colorectal et ‘sophage), et des lymphomes (151). Chez la femme, un quart des biopsies était des cancers du sein (485), suivi du col utérin (344), de la sphère gynécologique (218, ovaire et corps utérin), et de la peau (114). Les cancers du foie, du poumon ou de la vessie étaient peu fréquents. Ces résultats ne reflètent pas l'incidence ni l'actuel fardeau du cancer en Mauritanie puisque de nombreux patients diagnostiqués avec un cancer ne reçoivent pas d'examen anatomopathologique. Si, comme dans les pays avoisinants du Maroc et du Mali, les cancers du col et du sein sont les pathologies les plus fréquentes chez la femme, la distribution des cancers chez l'homme dans ce registre hospitalier diffère des résultats des registres de population du Maroc et du Mali où les cancers du poumon, du foie, de la prostate et de la vessie dominent.

Baba, Nacer Dine Ould Mohamed; Sauvaget, Catherine

2013-01-01

325

Les inconv?nients de perdre du poids  

PubMed Central

Résumé Objectif Explorer les raisons pour lesquelles la perte de poids à long terme échoue la plupart du temps et évaluer les conséquences de diverses trajectoires pondérales, y compris la stabilité, la perte et le gain. Source des données Les études qui évaluent les paramètres pondéraux dans la population sont en majorité observationnelles. Des données probantes de niveau I ont été publiées pour évaluer l’influence des interventions relatives au poids sur la mortalité et la qualité de vie. Message principal Seulement un petit pourcentage des personnes qui désirent perdre du poids réussissent à le faire de manière durable. La mortalité est la plus faible chez les personnes se situant dans la catégorie de poids élevé-normal et surpoids. La trajectoire pondérale la plus sécuritaire est la stabilité du poids avec une optimisation de la condition physique et métabolique. Il est démontré que la mortalité est plus faible chez les personnes ayant des comorbidités reliées à l’obésité si elles perdent du poids. Il est aussi établi que la qualité de vie sur le plan de la santé est meilleure chez les personnes obèses qui perdent du poids. Par contre, la perte de poids chez une personne obèse autrement en santé est associée à une mortalité accrue. Conclusion La perte de poids est recommandable seulement chez les personnes qui ont des comorbidités reliées à l’obésité. Les personnes obèses en santé qui veulent perdre du poids devraient être informées qu’il peut y avoir des risques à le faire. Une stratégie qui se traduit par un indice de masse corporelle stable avec une condition physique et métabolique optimisée, peu importe le poids, est l’option d’intervention la plus sécuritaire en ce qui concerne le poids.

Bosomworth, N. John

2012-01-01

326

Impact of rotation-driven particle repopulation on the thermal evolution of pulsars  

NASA Astrophysics Data System (ADS)

Driven by the loss of energy, isolated rotating neutron stars (pulsars) are gradually slowing down to lower frequencies, which increases the tremendous compression of the matter inside of them. This increase in compression changes both the global properties of rotating neutron stars as well as their hadronic core compositions. Both effects may register themselves observationally in the thermal evolution of such stars, as demonstrated in this Letter. The rotation-driven particle process which we consider here is the direct Urca (DU) process, which is known to become operative in neutron stars if the number of protons in the stellar core exceeds a critical limit of around 11% to 15%. We find that neutron stars spinning down from moderately high rotation rates of a few hundred Hertz may be creating just the right conditions where the DU process becomes operative, leading to an observable effect (enhanced cooling) in the temperature evolution of such neutron stars. As it turns out, the rotation-driven DU process could explain the unusual temperature evolution observed for the neutron star in Cas A, provided the mass of this neutron star lies in the range of 1.5 to 1.9M? and its rotational frequency at birth was between 40 (400 Hz) and 70% (800 Hz) of the Kepler (mass shedding) frequency, respectively.

Negreiros, Rodrigo; Schramm, Stefan; Weber, Fridolin

2013-01-01

327

Les Théories Implicites du Développement et de l’Education  

Microsoft Academic Search

Résumé  Les termes «théories implicites du développement et de l’éducation» désignents les connaissances relatives aux processus du\\u000a développement et à l’action éducative des parents, des enseignant(e)s ou des éducateurs qui, sans avoir la fonction professionnelle\\u000a de psychologues ou de psychiatres, prennent en charge l’éducation des enfants dans le cadre de la famille ou d’institutions\\u000a telles que la crêche et l’école. L’auteur

Christiane Vandenplas-Holper

1987-01-01

328

Origine du champ magnétique en cosmologie et formation des galaxies  

NASA Astrophysics Data System (ADS)

Ma thèse est le fruit d'un travail théorique centré sur deux questions fondamentales de la cosmologie actuelle: la formation des galaxies d'une part, et l'origine des champs magnétiques à grande échelle d'autre part. Je propose une solution au problème du sur-refroidissement dont souffrent les modèles de formation des galaxies. Pour cela, à l'aide d'un modèle analytique simple, puis au moyen de simulations numériques, j'explore les mécanismes de transfert et de stockage d'énergie par ondes d'Alfvén en œuvre dans le milieu interstellaire (MIS) biphasique. Je montre d'une part que les interférences des ondes internes aux nuages du MIS, négligées dans les études précédentes, renforcent l'efficacité d'injection d'énergie. D'autre part, les mouvements des nuages redistribuent l'énergie à l'échelle du système entier. Ils injectent aussi de l'énergie dans les nuages. Les modes vibratoires internes excités s'opposent à la compression des nuages et prolongent la durée de vie du système. Les nuages magnétisés constituent alors un réservoir d'énergie sur plusieurs temps dynamiques. A l'aide d'un modèle de protogalaxie biphasique, je montre que la dynamique des nuages du MIS et celle d'une protogalaxie sont équivalentes. Pour résoudre le sur-refroidissement, je propose la transposition des résultats du MIS au cas protogalactique. Malgré les diverses tentatives passées, l'origine du champ magnétique en cosmologie n'a pas trouvé d'explication satisfaisante. Or, sa place au sein du MIS et son rôle dans la formation des galaxies sont manifestes. Je propose dans ma thèse un nouveau mécanisme de magnétogenèse efficace à grande échelle, opérant à la réionisation de l'Univers, et reposant sur la pression de radiation anisotrope et inhomogène fournie par les premières structures lumineuses. A l'échelle galactique, le champ magnétique que j'obtiens est huit ordres de grandeur plus intense que dans les modèles habituels. De plus, il est généré avant tout aux grandes échelles, les champs à petite échelle étant largement supprimés. Ces deux propriétés permettent au modèle proposé de rendre compte des champs observés dans les grandes structures.

Langer, Mathieu

2002-12-01

329

Du pont ''Freon'' helps tap geothermal wells for power  

SciTech Connect

Low-grade heat from geothermal wells can now be harnessed to produce electricity by using Du Pont ''Freon'' IF as the power conversion fluid. The new system was developed by Turbonetics Energy Inc. The company's Organic Rankine Cycle (ORC) system takes advantage of the low boiling point (117F) of Du Pont ''Freon'' TF. Geothermal energy is harnessed by utilizing the heat from 200F to 400F water to vaporize the ''Freon'' power fluid. Then the fluid expands through a turbine and drives a generator. The system can produce from 600 kW of electric power.

Not Available

1984-07-01

330

Oxazolidinones, a new class of synthetic antibacterial agents: in vitro and in vivo activities of DuP 105 and DuP 721.  

PubMed Central

DuP 721 (p-acetylphenyloxooxazolidinylmethylacetamide) and DuP 105 (a methylsulfinyl derivative) are orally active representatives of the oxazolidinones, a new class of synthetic antibacterial agents. Their antibacterial spectrum includes staphylococci, streptococci, and Bacteroides fragilis strains. The compounds have equal activity against staphylococcal strains susceptible or resistant to beta-lactam antibiotics, including methicillin-resistant strains. The MICs for 90% of the strains (MIC90s) against staphylococcal isolates were 1 to 4 micrograms/ml for DuP 721 and 4 to 16 micrograms/ml for DuP 105, compared with 1 to 2 micrograms/ml for vancomycin, 0.5 microgram/ml for ciprofloxacin, and 2 to greater than 16 micrograms/ml for imipenem. The MIC90s against group D streptococci were 4 micrograms/ml for DuP 721, 16 micrograms/ml for DuP 105, and 2 micrograms/ml for vancomycin, ciprofloxacin, and imipenem. MIC90s against B. fragilis isolates were 4 micrograms/ml for DuP 721, 16 micrograms/ml for DuP 105, and 8 micrograms/ml for cefoxitin. DuP 721 and DuP 105 administered by either the oral or the parenteral route were protective against staphylococcal and streptococcal infections in mice. The 50% effective doses were 2 to 10 mg/kg for DuP 721, 9 to 23 mg/kg for DuP 105, and 2 to 12 mg/kg for vancomycin. These results indicate that further studies of compounds of the oxazolidinone series are warranted.

Slee, A M; Wuonola, M A; McRipley, R J; Zajac, I; Zawada, M J; Bartholomew, P T; Gregory, W A; Forbes, M

1987-01-01

331

Un cadre d'analyse du processus de vieillissement et de son influence sur le comportement d'achat du consommateur âgé  

Microsoft Academic Search

Cet article met en évidence un champ d'investigation peu abordé en marketing : l'influence du processus de vieillissement sur le comportement d'achat du consommateur de plus de 60 ans.Étudié le plus souvent de façon indirecte par le biais des variables d'âge chronologique et de retraite, le courant de la psychologie du développement se révèle également utile pour comprendre la manière

Denis Guiot

2006-01-01

332

Polymorphisme de l'apolipoprot?ine E dans la population du nord du Maroc: fr?quence et influence sur les param?tres lipidiques  

PubMed Central

Introduction L'objectif de ce travail est de déterminer les fréquences alléliques et génotypiques des sites polymorphes situés dans le gène de l'apolipoprotéine E (apo E) ainsi que leur impact sur les paramètres cliniques et lipidiques dans un échantillon de la population du nord du Maroc cliniquement diagnostiqué ADH. Méthodes Le génotype de l'apo E a été analysé par séquençage direct chez 46 patients cliniquement diagnostiqués ADH selon les critères standards. Résultats Les fréquences des allèles epsilon 3, epsilon 2 et epsilon 4 ont été respectivement 78.3%, 2.2% et 19.6%. La fréquence de l'allèle epsilon 4 est très élevée chez la population du nord du Maroc en comparaison avec les populations des autres régions marocaines. Elle est similaire à celle rapportée dans les pays de l'Europe du nord. Les taux du cholestérol total, du cholestérol LDL ainsi que la présence des xanthomes et les maladies cardiovasculaires ne différent pas entre les génotypes de l'apoE. En revanche, les résultats ont montré une influence de l'allèle epsilon4 sur le taux des triglycérides chez les sujets obèses. Conclusion Le génotype de l'apoE ne peut expliquer le phénotype clinique et biochimique présenté par des patients du Nord du Maroc cliniquement diagnostiqués ADH.

Benyahya, Fatiha; Barakat, Amina; Ghailani, Naima; Bennani, Mohcine

2013-01-01

333

Evolution: Help for the Confused.  

ERIC Educational Resources Information Center

Written in response to an earlier article questioning certain aspects of evolution theory. Discusses ontogeny and phylogeny, the basis of evolution, chance or purpose in evolution, micro and macro-evolution, reversibility, and the evolution processes today. (MA)

Scheer, Bradley T.

1979-01-01

334

Cost-Effective Remediation of Depleted Uranium (DU) at Environmental Restoration Sites  

SciTech Connect

Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon-development programs, at firing practice ranges, or in war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discrete, visually identifiable DU fragments mixed with native soil. The bulk-averaged DU activity is quite low, whereas DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is quite visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that DU is radioactive and visually identifiable makes it desirable to remove the DU ''contamination'' from the environment. The typical approach to conducting this DU remediation is to use radiation-detection instruments to identify the contaminant and then to separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

MILLER,MARK; GALLOWAY,ROBERT B.; VANDERPOEL,GLENN; JOHNSON,ED; COPLAND,JOHN; SALAZAR,MICHAEL

1999-11-03

335

Secular Evolution of Galaxies  

NASA Astrophysics Data System (ADS)

Preface; 1. Secular evolution in disk galaxies John Kormendy; 2. Galaxy morphology Ronald J. Buta; 3. Dynamics of secular evolution James Binney; 4. Bars and secular evolution in disk galaxies: theoretical input E. Athanassoula; 5. Stellar populations Reynier F. Peletier; 6. Star formation rate indicators Daniela Calzetti; 7. The evolving interstellar medium Jacqueline van Gorkom; 8. Evolution of star formation and gas Nick Z. Scoville; 9. Cosmological evolution of galaxies Isaac Shlosman.

Falcón-Barroso, Jesús; Knapen, Johan H.

2013-10-01

336

Long-term prognostic study of carcinoembryonic antigen (CEA) and carbohydrate antigen 15-3 (CA 15-3) in breast cancer  

Microsoft Academic Search

Background  Tumor markers are frequently used for screening and monitoring in oncology. We investigated the use of preoperative tumor\\u000a marker (carcinoembryonic antigen [CEA] and carbohydrate antigen [CA] 15-3) levels in estimating the prognosis of breast cancer\\u000a patients.\\u000a \\u000a \\u000a \\u000a Methods  We conducted a retrospective study in patients who underwent breast cancer surgery at National Cancer Center Hospital between\\u000a 1975 and 1994 and whose serum

Masahiro Uehara; Takayuki Kinoshita; Takashi Hojo; Sadako Akashi-Tanaka; Eriko Iwamoto; Takashi Fukutomi

2008-01-01

337

The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: Fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family  

SciTech Connect

The human pregnancy-specific glycoprotein (PSG) genes belong to the carcinoembryonic antigen (CEA) family, which in turn is a member of the immunoglobulin superfamily. We have analyzed a 700-kb cosmid contig spanning the PSG region on chromosome 19q13.2. The region contains 11 closely related PSG genes organized in tandem with a highly conserved structure and organization. Seven novel genes (CGM12 to CGM18) were found in the PSG region. CGM12 belongs to the CEA subgroup and appears to be a pseudogene. CGM13 to CGM18 forms a third new subgroup within the CEA gene family. The members of this new subgroup show 94-99% identity to each other but only 70-80% to other members of either the CEA or the PSG subgroups. They are composed of exons encoding two IgC-like domains and short hydrophilic carboxyl terminals similar to those of the PSGs. Unlike any of the known CEA family genes, however, they seem to lack the exon for an IgV-like N-terminal domain. 54 refs., 6 figs., 4 tabs.

Teglund, S.; Fraengsmyr, L.; Hammarstroem, S. [Univ. of Umea (Sweden)] [Univ. of Umea (Sweden)

1994-10-01

338

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody  

PubMed Central

Background: Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human colorectal cancer (CRC) previously treated with conventional chemotherapy would be sensitive to T-cell killing mediated by carcinoembryonic antigen (CEA)/CD3-bispecific T-cell-engaging BiTE antibody (MEDI-565). Methods: We analysed proliferation and lysis of CEA-positive (CEA+) CRC specimens that had survived previous systemic chemotherapy and biologic therapy to determine whether they could be killed by patient T cells engaged by MEDI-565 in vitro. Results: At low concentrations (0.1–1?ng?ml?1), MEDI-565+ T cells caused reduced proliferation and enhanced apoptosis of CEA+ human CRC specimens. High levels of soluble CEA did not impair killing by redirected T cells and there was no increase in resistance to T-cell killing despite multiple rounds of exposure. Conclusions: This study shows for the first time that metastatic CRC specimens derived from patients previously treated with conventional chemotherapy can be lysed by patient T cells. Clinical testing of cancer immunotherapies, such as MEDI-565 that result in exposure of tumours to large numbers of T cells, is warranted.

Osada, T; Hsu, D; Hammond, S; Hobeika, A; Devi, G; Clay, T M; Lyerly, H K; Morse, M A

2009-01-01

339

Past Tense Morphology in Cri Du Chat Syndrome: Experimental Evidence  

ERIC Educational Resources Information Center

It has been observed that persons with Cri du chat syndrome (CDCS) have poor language production. However, very few studies have addressed the question whether all aspects of language production are equally afflicted, or whether there are differences between for instance phonological and morphological abilities. The present study was aimed at…

Wium, Kristin; Kristoffersen, Kristian Emil

2008-01-01

340

Le marché du travail : une approche hors paradigmes  

Microsoft Academic Search

[eng] Different attempts are sketched : regional market, macroeconomics, female labor force participation, internai hierarchical market. They suggest fuuctioning processes quite distinct from the competitive equilibrium ; for example quantity adaptation to quantity desequilibrium (mobility, disguised unemployment) or a hierarchical model which offsets the net advantages equalization. [fre] Le marche du travail : une approche hors paradigmes . Robert Leroy.

Robert Leroy

1981-01-01

341

ASASSN-14du: optical spectroscopy indicates z=0  

NASA Astrophysics Data System (ADS)

We observed ASASSN-14du (Holoien et al., ATel #6308) with the 2.54-m Nordic Optical Telescope (NOT) equipped with ALFOSC on 2014 July 14. We obtained a single 30-s exposure in the SDSS r band starting at 20:59:54 UT.

Schulze, S.; Malesani, D.; Fynbo, J. P. U.; Milvang-Jensen, B.; Xu, D.; Cano, Z.; Jakobsson, P.; Martinez-Osorio, Y.

2014-07-01

342

W. E. B. Du Bois: Reform, Will, and the Veil  

ERIC Educational Resources Information Center

While W. E. B. Du Bois is widely recognized for his contributions to the sociology of race, his contributions to the foundations of sociology are largely ignored. His sociology is based on African American reformism, a version of pragmatism, and a contingent historicism. The basic view of sociology is one that emphasizes the role of chance and…

England, Lynn; Warner, W. Keith

2013-01-01

343

Pourfour du Petit Syndrome in a Patient with Thyroid Carcinoma  

Microsoft Academic Search

The clinical presentation of Pourfour du Petit syndrome (PdPs) is the opposite of Horner syndrome. Although all disorders underlying Horner syndrome may potentially present as PdPs, very few cases of the latter have been described in the literature. We report a patient with PdPs due to carotid compression by a thyroid tumor.

Sergi Martinez-Ramirez; Carles Roig; Joan Martí-Fàbregas

2010-01-01

344

Intensive Survey of the DuPage River Basin, 1983.  

National Technical Information Service (NTIS)

A cooperative survey of the aquatic resources of the DuPage River basin was conducted in 1983. Fish, macroinvertebrate, water, sediment, and habitat data were collected as part of the survey. Twenty-one stations were established within the West Branch of ...

1988-01-01

345

Khan Du II--A Series (Captioned Version).  

National Technical Information Service (NTIS)

The videos present Khan du, a magical wizard, in different situations, to show handicapped children that they can do many things if they develop a positive attitude. The series combines elements of fantasy, real-life situations, and everyday people to giv...

1994-01-01

346

Shock compression of DuPont Detasheet at low stress.  

National Technical Information Service (NTIS)

Detasheet is a DuPont-manufactured sheet exposure ((rho)(sub 0) = 1. 48 g/cm(sup 3)) that consists of 63% PETN and 8% nitrocellulose with various plasticizers and binders as the remainder. It is used extensively in metal forming and other industrial appli...

B. W. Asay J. B. Ramsay M. U. Anderson R. A. Graham

1991-01-01

347

Validation de la version française du Movement Imagery Questionnaire (MIQ)  

Microsoft Academic Search

L'objectif de cette étude est de valider une version française du Movement Imagery Questionnaire (Hall & Pongrac, 1983). Les analyses portent sur une population de 127 hommes et 68 femmes. Les résultats montrent une validité de construit (avec la totalité de la population) et une fiabilité test-retest (avec 26 participants) comparables à celles de la version anglaise. Les résultats suggèrent

Jean Lorant; Laurent Gaillot

2004-01-01

348

Understanding Evolution: Welcome to Evolution 101!  

NSDL National Science Digital Library

Understanding Evolution, a project funded by the National Science Foundation and the Howard Hughes Medical Institute, teaches the science and history of evolutionary biology. This portion of the site, "Welcome to Evolution 101!" provides an excellent introduction for students to this topic. Sections include the basics of evolution, the history of life, how evolution works, microevolution, speciation, macroevolution and the big questions that evolutionary biologists are trying to answer. Each subsection of the site includes a self-guided tutorial complete with text and useful images. The site is also available in Spanish and Turkish.

2004-01-01

349

Habitable Zone Evolution  

NASA Astrophysics Data System (ADS)

The location of the habitable zone around a star depends upon stellar luminosity and upon the properties of a potentially habitable planet such as its mass and near-surface volatile inventory. Stellar luminosity generally increases as a star ages whilst planetary properties change through time as a consequence of biological and geological evolution. Hence, the location of the habitable zone changes through time as a result of both stellar evolution and planetary evolution. Using the Earth's Phanerozoic temperature history as a constraint, it is shown that changes in our own habitable zone over the last 540 My have been dominated by planetary evolution rather than solar evolution. Furthermore, sparse data from earlier times suggests that planetary evolution may have dominated habitable zone development throughout our biosphere's history. Hence, the existence of a continuously habitable zone depends upon accidents of complex bio-geochemical evolution more than it does upon relatively simple stellar-evolution. Evolution of the inner margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations. Evolution of the outer margin of the habitable zone through time using three different estimates for climate sensitivity. The dashed line shows a typical predicted evolution assuming this was driven simply by a steady increase in solar luminosity. Solar evolution does not account for the observations.

Waltham, D.; Lota, J.

2012-12-01

350

Dynamic landscapes in human evolution and dispersal  

NASA Astrophysics Data System (ADS)

Archaeological studies of human settlement in its wider landscape setting usually focus on climate change as the principal environmental driver of change in the physical features of the landscape, even on the long time scales of early human evolution. We emphasize that landscapes evolve dynamically due to an interplay of processes occurring over different timescales. Tectonic deformation, volcanism, sea level changes, by acting on the topography, the lithology and on the patterns of erosion-deposition in a given area, can moderate or amplify the influence of climate at the regional and local scale. These processes impose or alleviate physical barriers to movement, and modify the distribution and accessibility of plant and animal resources in ways critical to human ecological and evolutionary success (King and Bailey, JHE 2006; Bailey and King, Antiquity 2011, Winder et al. Antiquity in press). The DISPERSE project, an ERC-funded collaboration between the University of York and the Institut de Physique du Globe de Paris, aims to develop systematic methods for reconstructing landscapes associated with active tectonics, volcanism and sea level change at a variety of scales in order to study their potential impact on patterns of human evolution and dispersal. Examples are shown to illustrate the ways in which changes of significance to human settlement can occur at a range of geographical scales and on time scales that range from lifetimes to tens of millennia, creating and sustaining attractive conditions for human settlement and exercising powerful selective pressures on human development.

Devès, Maud; King, Geoffrey; Bailey, Geoffrey; Inglis, Robyn; Williams, Matthew; Winder, Isabelle

2013-04-01

351

Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer.  

PubMed

Two-step radioimmunotargeting using a bispecific anti-CEA/anti-in-DTPA monoclonal antibody and an 111In-labeled DTPA dimer (diDTPA-TL) was evaluated nine times in eight patients with medullary thyroid cancer (MTC). Immunoscintigraphy was performed 5 and 24 hr after injection of 111In-diDTPA-TL. For five patients, radioimmunoguided surgery (RIGS) was performed using a hand-held gamma probe (sodium iodine), and a biodistribution study was performed 48 hr (four times) and 24 hr (one time) after injection of 111In-diDTPA-TL. Mean tumor uptake (%ID/kg in tumor) was 39 (range 2.75-139). In these five patients, immunoscintigraphy visualized all known tumors and detected unknown foci (US and CT were negative) in the neck (once) and neck and liver (once). Immunoscintigraphy, performed four times in search of a recurrence, detected unknown localizations in the mediastinum and neck (twice) and was negative twice. There were no false-positives. In three of five patients who had surgery, RIGS localized tumor foci not detected by the surgeon. RIGS failed to detect two small lesions (10 x 10 mm) corresponding to sites of fibrosis and microscopic cancer infiltration. Bispecific anti-CEA/anti-In-DTPA mediated targeting of 111In-diDTPA-TL provided elevated tumor uptake and tumor-to-normal tissue ratios. Radioimmunodetection of small MTC lesions is thus possible even when morphological imaging techniques prove negative. PMID:8326383

Peltier, P; Curtet, C; Chatal, J F; Le Doussal, J M; Daniel, G; Aillet, G; Gruaz-Guyon, A; Barbet, J; Delaage, M

1993-08-01

352

The effect of high level natural ionizing radiation on expression of PSA, CA19-9 and CEA tumor markers in blood serum of inhabitants of Ramsar, Iran.  

PubMed

Since several high level natural radiation areas (HLNRAs) exist on our planet, considerable attention has been drawn to health issues that may develop as the result of visiting or living in such places. City of Ramsar in Iran is an HNLRA, and is a tourist attraction mainly due to its hot spas. However, the growing awareness over its natural radiation sources has prompted widespread scientific investigation at national level. In this study, using an ELISA method, the level of expression of three tumor markers known as carcinoembryonic antigen (CEA), prostate-specific antigen (PSA) and carcino antigen 19-9 (CA19-9) in blood serum of 40 local men of Ramsar (subject group) was investigated and compared to 40 men from the city of Noshahr (control group). Noshahr was previously identified as a normal level natural radiation area (NLNRA) that is some 85 km far from Ramsar. According to statistical analysis, there was a significant difference in the levels of PSA and CA19-9 markers between the two groups (p < 0.001) with those of Ramsar being considerably higher. CEA level did not show any difference. Although some of the volunteers tested positive to the markers, they were in good health as confirmed by the physician. Moreover, the high number of positive markers in Noshahr was considerable. Therefore, future study is needed to further validate this result and to determine the level of positivity to tumor markers in both cities. PMID:24292395

Heidari, Mohammad Hassan; Porghasem, Mohsen; Mirzaei, Nazanin; Mohseni, Jafar Hesam; Heidari, Matine; Azargashb, Eznollah; Movafagh, Abolfazl; Heidari, Reihane; Molouki, Aidin; Larijani, Leila

2014-02-01

353

A collaborative study of a test for carcinoembryonic antigen (CEA) in the sera of patients with carcinoma of the colon and rectum  

PubMed Central

Five university centres in Canada and the United States have collaborated in a study of a test for carcinoembryonic antigen, with the Montreal General Hospital laboratory acting as the reference laboratory, examining duplicate halves of specimens from patients examined in local laboratories. Between June 1971 and April 1972, 503 patients were admitted to the study, 146 with cancer of the colon or rectum. Discrimination between colo-rectal cancer and “other” diagnoses was good at 2.5 ng./ml. or more, such a result being obtained in 66% of the patients with colo-rectal cancer in the local laboratories and 62% in the reference laboratory compared with 39% and 33% respectively of patients with “other” diagnoses. Patients with Duke's C lesions of the colon or rectum were more likely to have raised CEA levels than patients with more localized lesions. CEA was also more commonly found in patients with other cancers and in patients with liver disease than in patients with other (benign) diagnoses. It is concluded that the test can be reproduced in other laboratories and that it or another simplified technique could become an important diagnostic aid for colo-rectal cancer.

1972-01-01

354

The Evolution Solution: Teaching Evolution without Conflict  

ERIC Educational Resources Information Center

Surveys reveal that many in our society have an inadequate and inaccurate understanding of evolution (Alters & Alters, 2001). Much of this can be traced directly to popular misconceptions about the nature of science. This, in turn, can be linked to misrepresentation by those opposed to evolution, although inadequate or ineffective treatment by ill…

Flammer, Larry

2006-01-01

355

Understanding Evolution: An Evolution Website for Teachers  

ERIC Educational Resources Information Center

While many states are facing challenges to the teaching of evolution in their science classrooms, the University of California Museum of Paleontology, working with the National Center for Science Education, has developed a useful web-based resource for science teachers of all grade- and experience-levels. Understanding Evolution (UE) was developed…

Scotchmoor, Judy; Janulaw, Al

2005-01-01

356

Caractérisation du seuil de dommage dans les cristaux de saphir dopé au titane avec des impulsions de durée nanoseconde, picoseconde et femtoseconde  

NASA Astrophysics Data System (ADS)

Le verrou principal pour le développement des systèmes femtoseconde robustes et rentables est l'incertitude du seuil de dommages du cristal de Ti: Saphir. Nous avons d'abord caractérisé le seuil diélectrique de dommages du Ti : Saphir.

Canova, F.; Chambaret, J.-P.; Mourou, G.; Sentis, M.; Uteza, O.; Delaporte, P.

2006-12-01

357

Oxygen and Biological Evolution.  

ERIC Educational Resources Information Center

Discussed is the evolution of aerobic organisms from anaerobic organisms and the accompanying biochemistry that developed to motivate and enable this evolution. Uses of oxygen by aerobic organisms are described. (CW)

Baugh, Mark A.

1990-01-01

358

Mistakes and Molecular Evolution.  

ERIC Educational Resources Information Center

Examines the role mistakes play in the molecular evolution of bacteria. Discusses the interacting physical, chemical, and biological factors that cause changes in DNA and play a role in prokaryotic evolution. (DDR)

Trevors, J. T.

1998-01-01

359

The Evolution of Design  

ERIC Educational Resources Information Center

Describes the basic logic behind the modern view of evolution theory. Despite gaps in fossil records, evidence is indicative of the origin of life from nonliving molecules and evolution of higher forms of life from simpler forms. (PS)

Stebbins, G. Ledyard

1973-01-01

360

State Standards and Evolution  

NSDL National Science Digital Library

Most states' science-education standards support the teaching of evolution, but many in the general public and some policymakers want science classrooms to include creationism. As a result of this influence, are educators teaching creationism even though state standards support the teaching of evolution? To answer this question, the author examined evolution education in Minnesota to determine if teachers emphasize evolution in their biology classes as mandated by Minnesota's state educational standards.

Moore, Randy

2004-07-01

361

Rupture diaphragmatique droite avec passage total et isol? du foie en intra-thoracique  

PubMed Central

La rupture traumatique de la coupole diaphragmatique droite avec hernie du foie dans le thorax est une lésion rare. Elle est souvent intégrée dans le cadre d'un poly-traumatisme, dont elle est un critère de gravité. Elle expose, précocement ou tardivement, à des complications cardio-pulmonaires par compression. Le diagnostic d'une rupture diaphragmatique droite est difficile à établir. En effet, ses signes cliniques sont peu spécifiques et l'imagerie peut être prise en défaut du faite qu'elle visualise les organes ascensionnés mais plus difficilement la rupture elle-même. La voie d'abord thoracique est souvent préférée du fait des difficultés de l'exposition du diaphragme en présence du foie. Nous rapportons un cas d'une rupture diaphragmatique droite avec passage isolé et total du foie en intra-thoracique diagnostiquée au cinquième jour d'hospitalisation chez un polytraumatisé.

Turki, Mohamed; Barhoumi, Mohamed Hafed; Hajji, Hassen; Chemchik, Heithem; M'barek, Bechir

2011-01-01

362

Evolution & Diversity in Plants.  

ERIC Educational Resources Information Center

Summarizes recent findings that help in understanding how evolution has brought about the diversity of plant life that presently exists. Discusses basic concepts of evolution, diversity and classification, the three-line hypothesis of plant evolution, the origin of fungi, and the geologic time table. Included are 31 references. (CW)

Pearson, Lorentz C.

1988-01-01

363

Evolution for Young Victorians  

NASA Astrophysics Data System (ADS)

Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's Origin of Species. Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented evolution in a non-Darwinian form amenable to religious interpretation.

Lightman, Bernard

2012-07-01

364

Evolution of Biological Complexity  

Microsoft Academic Search

In order to make a case for or against a trend in the evolution of complexity in biological evolution, complexity needs to be both rigorously defined and measurable. A recent information-theoretic (but intuitively evident) definition identifies genomic complexity with the amount of information a sequence stores about its envi- ronment. We investigate the evolution of genomic complexity in populations of

Christoph Adami; Charles Ofria; Travis C. Collier

2000-01-01

365

Taming architectural evolution  

Microsoft Academic Search

In the world of software development evolves. So, then, do software architectures. Unlike source code, for which the use of a configuration management (CM) system is the predominant approach to capturing and managing evolution, approaches to capturing and managing architectural evolution span a wide range of disconnected alternatives. This paper contributes a novel architecture evolution environment, called Mae, which brings

André van der Hoek; Marija Mikic-Rakic; Roshanak Roshandel; Nenad Medvidovic

2001-01-01

366

Arguing for Evolution.  

ERIC Educational Resources Information Center

Discusses the Kansas State Board of Education's decision to remove references to evolution and cosmology from the state's education standards and assessment. Advocates the need to teach evolution in high schools for a meaningful biology education. Addresses the question whether the teaching of evolution poses a threat to Christianity or other…

Ayala, Francisco J.

2000-01-01

367

AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment.  

PubMed

The palliative therapy effect by docetaxel for CRPC patients makes it urgent to improve the therapy. It was suggested that PI3K and androgen receptor-directed combination therapy may be effective for prostate cancer (PCa) patients PTEN negative. However, for those patients PTEN positive, the mechanism of anti-apoptosis survival of cancer cells is not yet well defined. Amplification of AURKA has been detected in 5% of PCa. In this work, Du145, a PTEN positive PCa cell model, was employed to investigate the role of aurora kinase a (AURKA) on cell growth. Inhibition of AURKA expression by shRNA markedly reduced prostate cancer cell viability. Furthermore, we demonstrate that AURKA inhibition induced a remarkable downregulation of AKT activity and Bax induction. Moreover, specific inhibition of the activity of AURKA, but not other aurora family members, by small molecular chemical inhibitors induced significant cell killing effects. Notably, AURKA inhibition sensitized prostate cancer cells to docetaxel treatment. Our work suggests that AURKA-directed monotherapy or combination therapy with docetaxel could be a potent treatment for PCa patients in future. PMID:23634246

He, Wei; Zhang, Min-Guang; Wang, Xiao-Jing; Zhong, Shan; Shao, Yuan; Zhu, Yu; Shen, Zhou-Jun

2013-01-01

368

Karl Marx: l'organisation et l'exploitation du travail  

Microsoft Academic Search

Ce texte expose les principaux traits de l'analyse par Marx du procès capitaliste d'exploitation de la force de travail. Après avoir rappelé ce qu'est la théorie de l'exploitation, les notions de coopération simple et de travailleur collectif permettent d'identifier le double aspect du commandement dans la production capitaliste. Dans la manufacture, où la subordination du travail est tout d'abord formelle,

Bruno Tinel

2006-01-01

369

Notes sur l'écologie et l'éthologie des espèces du genre Lasius (Hymenoptera Formicid?)  

Microsoft Academic Search

Résumé L'observation de l'emplacement et du mode de nidification des espèces du genreLasius dans leur milieu naturel a permis de mettre en évidence des exigences écologiques bien définies. De même, la complexité des techniques mises en ?uvre et le type de matérian employé lors de la construction des nids permettent de présenter un classement des mœurs des espèces du genreLasius.

Ch. Gaspar

1965-01-01

370

Le campus « vert » de proximité du Queen Margaret University College (Royaume-Uni)  

Microsoft Academic Search

Le nouveau campus du Queen Margaret University College, au Royaume-Uni, est dans sa conception un centre éducatif de proximité, soucieux du développement durable. Les étudiants et le personnel initialement consultés au sujet de la conception du campus ont montré qu’ils souhaitaient vivement disposer d’un environnement écologiquement viable, dans lequel tous puissent jouir de très nombreux espaces verts. C’est pourquoi les

Susan Woodman

2006-01-01

371

L’Échelle de développement pubertaire : équivalence en langue française du «Pubertal Development Scale»  

Microsoft Academic Search

L’Échelle de développement pubertaire ( EDP; version française du «Pubertal Development Scale» de Petersen et Crockett, 1985) est une mesure auto-révélée du niveau de maturation pubertaire à l’adolescence. Cette étude visait principalement la validation de l’ EDP auprès d’une population d’élèves du secondaire. L’ EDP a été administrée à trois reprises auprès de 255 élèves lors des deux premières années

Pierrette Verlaan; Stéphane Cantin; Michel Boivin

2001-01-01

372

La répartition des compétences en Europe Le double éclairage du droit et de l'économie  

Microsoft Academic Search

De multiples raisons plaident en faveur d'un réexamen de la répartition des compétences en Europe: complexité et perte d'efficacité des procédures, absence de légitimité vis-à-vis du citoyen, impact de l'élargissement et conséquences à long terme de l'euro. Du point de vue du droit, le principe de concurrence sur le grand marché a joué un rôle déterminant par ses effets propres

Robert Boyer; Mario Dehove

2003-01-01

373

Une tumeur exceptionnelle du doigt: la tumeur fibreuse solitaire  

PubMed Central

La tumeur Fibreuse solitaire (TFS) est une prolifération fusocellulaire rare, souvent de localisation intra-thoracique. Nous rapportons le cas d'une localisation exceptionnelle au niveau du 3ème doigt de la main droite. En l'absence de marqueur spécifique l'interprétation de l'immuno-marquage dépend du contexte histo-morphologique. La similitude avec les différents néoplasmes à cellules fusiformes des tissus mous rend le diagnostic de ces tumeurs mésenchymateuses difficile et tardif. Dans 20à 30% des cas le comportement de la TFS est celui d'une tumeur maligne localement agressive et récidivante, avec des métastases rares et tardives. Ce comportement impose une surveillance prolongée après exérèse chirurgicale.

Harmouch, Taoufiq; Hamas, Nawal; Daoudi, Abdelkrim; Amarti, Afaf

2011-01-01

374

Passive Time Coincidence Measurements with HEU and DU Metal Castings  

SciTech Connect

A Department of Energy sponsored Oak Ridge National Laboratory/Y-12 National Security Complex program of passive time coincidence measurements has been initiated at Y-12 to evaluate the ability to determine the presence of high enriched uranium (HEU) and distinguish it from depleted uranium (DU). This program uses the Nuclear Materials Identification System (NMIS) without an active interrogation source. Previous passive NMIS measurements with Pu metal and Pu oxide have been successful in determining the Pu mass, assuming a known 240Pu content. The spontaneous fission of uranium metal is considerably lower than Pu and measurements of this type have been performed at Lawrence Livermore National Laboratory. This work presents results of measurements of HEU and DU metal castings using moderated 3He detectors.

McConchie, Seth M [ORNL; Hausladen, Paul [ORNL; Mihalczo, John T [ORNL; Wright, Michael C [ORNL; Archer, Daniel E [ORNL

2008-01-01

375

Uccle Carte du Ciel Plate Catalogue Present in the WFPDB  

NASA Astrophysics Data System (ADS)

We present the catalogue of the Carte du Ciel plates collected at the Royal Observatory of Belgium (ROB) and incorporated in the Wide-Field Plate Database. The catalogue comprises the descriptive information for 682 plates obtained with the Gautier 0.33-m equatorial telescope in the framework of the Carte du Ciel project in the period 1908-1939. The plates were taken using triple exposures with duration of 15 to 30 minutes. An analysis of the ROB CdC catalogue's content is presented. The catalogue, as well as the plate previews taken with a flatbed scanner AGFA (model DUOSCAN HiD) with a resolution of 250 dpi in TIFF format (of size 2.5 MB), are available on-line at http://www.skyarchive.org/.

Tsvetkova, Katya; Tsvetkov, Milcho; Lampens, Patricia; Duval, David

2007-08-01

376

A Conversation with Lee Alvin DuBridge - Part I  

NASA Astrophysics Data System (ADS)

Physicist Lee A. DuBridge became president of the California Institute of Technology in 1946. In this interview he recalls the immediate problems he faced, including his dealings with Robert A. Millikan, whom he replaced as chief administrator of the institute; institute financing and inadequate salaries. DuBridge also talks about the advent of federal support for peacetime science and Millikan's distaste for it; his close working relationship with Robert F. Bacher, who came to the institute in 1949 as chairman of the Division of Physics, Mathematics, and Astronomy; his recollections of the meteorologist Irving P. Krick, the physicist Alexander Goetz, and the chemist Linus Pauling; and his attempts to build up the Humanities Division.

Goodstein, Judith R.

377

La Carte du Ciel, histoire et actualité d'un projet scientifique international  

NASA Astrophysics Data System (ADS)

Cet ouvrage collectif analyse la genèse, le déploiement, l'abandon et les résurgences récentes de la Carte du Ciel. Au-delà de son échec avéré, la Carte du Ciel fut en effet le premier projet international astronomique de grande envergure, remarquable notamment par son organisation à l'échelle du globe. Bien plus que par son objet ou les techniques mobilisées pour sa réalisation, c'est par cette vision que la Carte du Ciel ouvre une nouvelle ère pour l'astronomie.

Lamy, J.

2008-06-01

378

Le syndrome de Cri du Chat : A propos d'une observation  

PubMed Central

Le syndrome du Cri du Chat (Cri du Chat syndrome, CdCS) est une anomalie chromosomique résultant d’une délétion de taille variable de l’extrémité du bras court du chromosome 5 (5p), incluant une région critique située en p15.2. Il représente une des délétions chromosomiques les plus fréquentes, son incidence dans la population générale est de 1/20 000 à 1/50 000. Les caractéristiques cliniques comprennent un cri monochromatique aigu, une microcéphalie, une dysmorphie cranio-faciale caractéristique évoluant avec l’âge et un retard mental et psychomoteur important. La taille de la délétion est variable, Le traitement est fonction des différents symptômes. Un remaniement chromosomique parental est retrouvé dans 12% des cas et la majorité des délétions responsables de la maladie du cri-du-chat surviennent de novo. Nous présentons une observation d’un syndrome du Cri du Chat, confirmé par caryotype métaphasique (46,XY,del(5)(p13) de novo). A travers cette observation nous mettrons à jour, les actualités scientifiques de ce rare syndrome, ainsi que la place des explorations cytogénétiques dans le diagnostic précis et le conseil génétique des syndromes dysmorphiques.

Ouldim, Karim; Samri, Imane; Bouguenouch, Laila; Hamdaoui, Hasna; Otmani, Ihsan El; Hbibi, Mohamed; Chaouki, Sana; Hida, Moustapha

2012-01-01

379

Diagnosis of breast carcinoma with radiolabeled monoclonal antibodies (MoAbs) to carcinoembryonic antigen (CEA) and human milk fat globulin (HMFG).  

PubMed

The current study attempted to assess the potential proficiency of radioimmunodetection (RAID) of primary, residual, multicentric, and recurrent breast carcinoma using two radiolabeled murine monoclonal antibodies (MoAbs), anti-human milk fat globulin (HMFG1) labeled with iodine (123I) and anti-carcinoembryonic antigen (CEA) labeled with technetium (99Tc). Thirteen patients with suspicious clinical and/or mammographic primary or recurrent breast carcinoma were studied in a phase I-II prospective, consecutive, nonrandomized, noncontrolled study. Five patients received intravenous infusion with 0.5-2.0 mg anti-CEA MoAb type CYT 380 labeled with 99Tc [13-22 millicurie (mCI)] and 8 patients received intravenous infusion with 0.25-1.0 mg anti-HMFG1 MoAb (Unipath, U.K.) labeled with 123I (4-17 mCI). Both MoAbs used in this study demonstrated ability to bind specifically to breast cancer lesions, resulting in successful RAID in 10 of 12 of studied patients (5 of 5 patients in the anti-CEA-99Tc and 5 of 7 in the anti-HMFG-123I group--accuracy 83.3%). One patient was excluded due to protocol violation. Seven patients had true-positive scans when correlated with surgery (sensitivity 87.5%). The MoAb scans accurately diagnosed lesions in 3 of the 4 primary invasive breast carcinomas confirmed histologically. Presence of residual carcinoma following wide excision was established in 1 of 2 patients and presence of soft tissue metastases in 3 patients. Three patients had true-negative scan (specificity 75%): 2 patients presented with suspicious mammographic recurrence postlumpectomy and 1 patient had questionable soft tissue recurrence. One patient with primary breast carcinoma had a false-negative scan and another had a false-positive scan in the presence of fibrosis following lumpectomy and radiation therapy. No adverse reactions were noted in the patients studied. RAID findings were confirmed by immunohistochemistry in 6 of 9 cases studied. Our data suggest that radiolabeled MoAbs used in this study are potentially useful diagnostic agents for evaluation of primary or recurrent breast carcinoma, particularly in the areas where conventional methodology is limited. PMID:7583706

Rosner, D; Nabi, H; Wild, L; Ortman-Nabi, J; Hreshchyshyn, M M

1995-01-01

380

Politique des déchets : l'approche du Royaume-Uni  

Microsoft Academic Search

[fre] Politique des déchets : l'approche du Royaume-Uni . L'évolution récente de la réglementation européenne en dématière de déchets risque d'entraîner des coûts importants pour les États membres. L'exemple britannique est d'autant plus intéressant pour la France que les deux pays présentent des similitudes : quantité presque identique de déchets ménagers (environ 20 millions de tonnes), faible capacité des incinérateurs

David Litvan

1995-01-01

381

Note sur les Buprestides du Museum de Leiden  

Microsoft Academic Search

M. le Dr. H. C. Blöte, entomologiste du Rijksmuseum van Natuurlijke Historie à Leiden (Hollande) m'a confié l'étude de matériaux indéterminés appartenant aux collections de cet établissement, parmi ceux-ci j'ai trouvé quelques espèces nouvelles dont je donne ci-dessous la description. Les types de toutes les espèces décrites se trouvent à Leiden, quelques paratypes existent également dans ma collection et dans

A. Thery

1935-01-01

382

T. N. Thiele and the Carte DU Ciel  

NASA Astrophysics Data System (ADS)

T. N. Thiele participated in the astrographic conference in Paris 1887 and was the first theoretician to reduce and analyse the photographic plates of the Henry brothers. He was an enthusiastic supporter of photographic astrometry because of its elimination of personal errors. However, for different reasons he did not want the Copenhagen Observatory to take responsibility for a Carte du Ciel zone. Thiele's life and work and his plans for the development of astrometry are presented.

Kristensen, L. K.

383

Diagnostic prénatal (DPN) des maladies héréditaires du métabolisme (MHM)  

Microsoft Academic Search

Résumé  Les maladies héréditaires du métabolisme (MHM) sont un groupe de plus de 500 maladies génétiques rares affectant le métabolisme\\u000a cellulaire. Elles sont donc souvent ubiquitaires même si l’atteinte d’un organe peut être prédominante. La plupart de ces\\u000a maladies se déclarent pendant l’enfance par des atteintes multi viscérales et\\/ou neurologiques souvent sévères. Il existe\\u000a cependant une très grande variabilité clinique pour

Irène Maire

2004-01-01

384

L'application du principe pollueur-payeur en agriculture  

Microsoft Academic Search

[fre] La pollution agricole et la contamination des eaux souterraines ou superficielles par les nitrates et les pesticides a conduit certains pays à s'interroger sur l'application du principe pollueur-payeur (PPP) en agriculture. Cet article relate les expériences menées dans les pays de l'OCDE. A l'exception de la taxe autrichienne sur les nitrates, les taux utilisés restent trop peu élevés pour

Thierry Lavoux; David Baldock

1992-01-01

385

Une théorie du quiproquo pour la gestion stratégique des risques  

Microsoft Academic Search

Cet article a pour objectif de présenter l'intérêt d'une théorie du quiproquo pour l'analyse, la compréhension et le pilotage des situations de conduite à risques. Dans cette optique, nous proposerons une nouvelle analyse d'une catastrophe bien connue : il s'agit de l'accident le plus grave de l'histoire de l'aviation civile qui a eu lieu le 27 mars 1977 sur le

Mathias Szpirglas

2005-01-01

386

La lettre du Département d'Obstétrique et de gynécologie  

Microsoft Academic Search

J'aimerais offrir à tous les membres du Départe- ment, aux professeurs et aux professionnels de sou- tien, mes plus sincères vœux pour la nouvelle an- née. J'espère que 2007 sera pour vous une année de développement personnel et professionnel, rem- plie de satisfaction et de réussites. Je crois que nous pouvons regarder 2006 avec une certaine fierté. Sur le plan

William Fraser

387

Vers une rupture profonde du modèle énergétique mondial  

Microsoft Academic Search

Le paradigme énergétique mis en œuvre avec la révolution industrielle au début du XIXème siècle aura duré deux siècles. Il n'est aujourd'hui plus soutenable en raison d'une contrainte amont sur les ressources d'hydrocarbures et d'une contrainte aval sur la capacité de l'atmosphère à stocker les gaz à effet de serre. Un nouveau paradigme énergétique permettant de surmonter cette double contrainte

Patrick Criqui

2009-01-01

388

Pneumonie varicelleuse du nouveau-n?: ? propos ?un cas  

PubMed Central

La varicelle est une maladie contagieuse fréquente chez ?enfant, mais rare chez la femme enceinte. La survenue de varicelle pendant la grossesse peut entrainer des complications périnatales dont la pneumonie varicelleuse du nouveau-né. Cette atteinte pulmonaire est accompagnée ?un taux élevé de décès. Nous rapportons un cas de pneumonie varicelleuse grave chez un nouveau-né qui a été contaminé par le virus de la varicelle par voie transplacentaire. Le tableau clinique associait un syndrome infectieux, une détresse respiratoire sévère avec coma, des râles sous-crépitants diffus aux deux champs pulmonaires, et une éruption cutanée disséminée faite de macules, vésicules, croûtes, évocatrice de la varicelle. La radiographie du thorax montrait un syndrome interstitiel diffus aux deux poumons. Un traitement par ?aciclovir injectable associé à ?oxygénothérapie continue a permis une évolution vers la guérison. La pneumonie varicelleuse du nouveau-né est situation associée à une forte mortalité mais dont le traitement par ?aciclovir injectable peut permettre la guérison. La prophylaxie par administration intraveineuse ?aciclovir ou ?immunoglobulines polyvalentes chez le nouveau-né permet de diminuer la sévérité et la mortalité de la varicelle périnatale.

Noubiap, Jean Jacques Nzeale; Tene, Ulrich Gael; Bongoe, Adamo

2012-01-01

389

Case-control study of cancer among Du Pont employees with potential for exposure to dimethylformamide  

SciTech Connect

This case-control study was undertaken to determine whether the risk of developing cancers of the buccal cavity and pharynx (N = 39), liver (N = 6), prostate (N = 43), testis (N = 11), or malignant melanoma of the skin (N = 39) is related to exposure to dimethylformamide (DMF). Case and control subjects were obtained from four Du Pont plants. DMF is produced at one plant and used at the other three. Cancer cases identified from the company Cancer Registry comprise those reported among active male employees at the study plants during 1956 to 1985. For each case, two control subjects were selected, matched on sex, payroll class (wage or salary), birth year, and plant. To determine whether an employee could have been exposed to DMF during his career at the plant, all jobs with potential for exposure to DMF were identified. Each job was assigned an exposure ranking based on DMF industrial hygiene air monitoring, DMF metabolite (measured as N-methylformamide in urine) monitoring, and knowledge of the evolution of manufacturing processes and workplace exposure controls. Each employee's DMF exposure pattern was then characterized as (a) ever v never having been exposed to DMF and (b) highest DMF exposure experienced. Summary analyses for all plants combined showed no statistically significant association between ever having been exposed to DMF and subsequent development of cancers of the buccal cavity and pharynx, liver, malignant melanoma, prostate, and testis. Examined by plant site, prostate cancer at one plant was significantly elevated, based on three case subjects exposed out of four.

Walrath, J.; Fayerweather, W.E.; Gilby, P.G.; Pell, S.

1989-05-01

390

Systems assessment of water savings impact of controlled environment agriculture (CEA) utilizing wirelessly networked Sense•Decide•Act•Communicate (SDAC) systems.  

SciTech Connect

Reducing agricultural water use in arid regions while maintaining or improving economic productivity of the agriculture sector is a major challenge. Controlled environment agriculture (CEA, or, greenhouse agriculture) affords advantages in direct resource use (less land and water required) and productivity (i.e., much higher product yield and quality per unit of resources used) relative to conventional open-field practices. These advantages come at the price of higher operating complexity and costs per acre. The challenge is to implement and apply CEA such that the productivity and resource use advantages will sufficiently outweigh the higher operating costs to provide for overall benefit and viability. This project undertook an investigation of CEA for livestock forage production as a water-saving alternative to open-field forage production in arid regions. Forage production is a large consumer of fresh water in many arid regions of the world, including the southwestern U.S. and northern Mexico. With increasing competition among uses (agriculture, municipalities, industry, recreation, ecosystems, etc.) for limited fresh water supplies, agricultural practice alternatives that can potentially maintain or enhance productivity while reducing water use warrant consideration. The project established a pilot forage production greenhouse facility in southern New Mexico based on a relatively modest and passive (no active heating or cooling) system design pioneered in Chihuahua, Mexico. Experimental operations were initiated in August 2004 and carried over into early-FY05 to collect data and make initial assessments of operational and technical system performance, assess forage nutrition content and suitability for livestock, identify areas needing improvement, and make initial assessment of overall feasibility. The effort was supported through the joint leveraging of late-start FY04 LDRD funds and bundled CY2004 project funding from the New Mexico Small Business Technical Assistance program at Sandia. Despite lack of optimization with the project system, initial results show the dramatic water savings potential of hydroponic forage production compared with traditional irrigated open field practice. This project produced forage using only about 4.5% of the water required for equivalent open field production. Improved operation could bring water use to 2% or less. The hydroponic forage production system and process used in this project are labor intensive and not optimized for minimum water usage. Freshly harvested hydroponic forage has high moisture content that dilutes its nutritional value by requiring that livestock consume more of it to get the same nutritional content as conventional forage. In most other aspects the nutritional content compares well on a dry weight equivalent basis with other conventional forage. More work is needed to further explore and quantify the opportunities, limitations, and viability of this technique for broader use. Collection of greenhouse environmental data in this project was uniquely facilitated through the implementation and use of a self-organizing, wirelessly networked, multi-modal sensor system array with remote cell phone data link capability. Applications of wirelessly networked sensing with improved modeling/simulation and other Sandia technologies (e.g., advanced sensing and control, embedded reasoning, modeling and simulation, materials, robotics, etc.) can potentially contribute to significant improvement across a broad range of CEA applications.

Campbell, Jonathan T.; Baynes, Edward E., Jr.; Aguirre,Carlos (University of Texas at El Paso, El Paso, TX); Jordan, Jon (University of Arizona, Tucson, AZ); Giacomelli, Gene (University of Arizona, Tucson, AZ); Waggoner, Justin (New Mexico State University, Las Cruces, NM); Loest, Clint (New Mexico State University, Las Cruces, NM); Szumel, Leo; Nakaoka, Tyler; Pate, Ronald C.; Berry, Nina M.; Pohl, Phillip Isabio; Aguirre, Francisco Luis (Invernaderos y Maquinaria Aguirre, Cd., Aldama, Chihuahua, Mexico); Aguilar, Jose (University of Texas at El Paso, El Paso, TX); Gupta, Vipin P.; Ochoa, Juan (University of Texas at El Paso, El Paso, TX); Davis, Jesse Zehring; Ramos, Damian (University of Texas at El Paso, El Paso, TX)

2005-02-01

391

Gestion du risque et information des consommateurs : l'exemple du méthyle-mercure dans le poisson  

Microsoft Academic Search

De plus en plus fréquemment, l'information des consommateurs est utilisée comme un outil de gestion des risques sanitaires, par le biais de l'étiquetage, de programmes de prévention ou de recommandations de consommation. Nous nous sommes particulièrement intéressés à ce dernier outil utilisé au niveau international pour la gestion du risque lié à la présence de méthyle-mercure dans le poisson. Dans

Sandrine Blanchemanche; Stéphan Marette; Jultta Roosen; Philippe Verger

2007-01-01

392

Investigation of Barcelona and Du Chilly filbert nuts. I. Chemical study of Barcelona and Du Chilly filbert nuts and oils  

Microsoft Academic Search

Summary  Barcelona and Du Chilly fibert nuts have been analyzed for their principal constituents. The characteristics of the oils obtained\\u000a by solvent extraction and by cold expression have been determined and their fatty acid composition has been ascertained. Most\\u000a of the chemical and physical characteristics of the oils as determined in this laboratory agree well with values previously\\u000a reported by other

S. C. Fang; D. E. Bullis

1949-01-01

393

Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA  

SciTech Connect

As part of the work scope set in the French law on high level long lived waste R&D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality.

Marvy, A.; Lioure, A; Heriard-Dubreuil, G.; Gadbois, S.; Schneider, T.; Schieber, C.

2003-02-24

394

CONTRAINTE CLIMATIQUE DES NAPPES D'EAU SOUTERRAINES EN ZONE SOUDANO-SÉHÉLIENNE: CAS DE LA NAPPE PHRÉATIQUE DU BASSIN DE LA NÉMA DANS LA RÉGION DU SINE AU CENTRE OUEST DU SÉNÉGAL  

Microsoft Academic Search

Résumé : La zone de l'étude est un bassin versant expérimental et de recherche d'une superficie d'environ 50 km². Il constitue l'aire d'influence d'une petite rivière (la Néma), une des innombrables vallées qui incisent le plateau continental terminal du basin sédimentaire sénégalo- mauritanien. Situé au centre-ouest du Sénégal, ce bassin de trouve en pleine zone soudano-sahélien qui connaît depuis plus

Fatou DIOP NGOM; Raymond MALOU; Honoré DACOSTA; Anastasie MENDY

395

76 FR 39842 - Draft Investigation Report-DuPont Belle; Public Comment Requested  

Federal Register 2010, 2011, 2012, 2013

...CHEMICAL SAFETY AND HAZARD INVESTIGATION...at the DuPont plant in Belle, West...the U.S. Chemical Safety Board (CSB...at the DuPont plant involved releases...Comments, U.S. Chemical Safety Board, 2175...

2011-07-07

396

Exaltation du signal de génération de second harmonique sur des films chiraux anisotropes  

NASA Astrophysics Data System (ADS)

Nous avons mis en évidence l'exaltation de la rotation optique et du dichroïsme circulaire du signal de génération de second harmonique sur des films chiraux anisotropes. Un modèle simple d'électron se déplaçant sur une hélice permet de bien expliquer ces phénomènes.

Lascoux, N.; Degert, J.; Freysz, E.; Verbiest, Th.; Katz, T. J.

2006-10-01

397

Of Faith and Fiction: Teaching W. E. B. Du Bois and Religion  

ERIC Educational Resources Information Center

W. E. B. Du Bois (1868-1963) is widely known as a champion for the political rights of African Americans, founder of the National Association for the Advancement of Colored People (NAACP), aggressive advocate of Pan-Africanism, staunch supporter of female suffrage, and one of the creative forces behind the Harlem Renaissance. Further still, Du

Sinitiere, Phillip Luke

2012-01-01

398

Using SeDuMi 1.02, A Matlab toolbox for optimization over symmetric cones  

Microsoft Academic Search

SeDuMi is an add-on for MATLAB, which lets you solve optimization problems with linear, quadratic and semidefiniteness constraints. It is possible to have complex valued data and variables in SeDuMi. Moreover, large scale optimization problems are solved efficiently, by exploiting sparsity. This paper describes how to work with this toolbox.

Jos F. Sturm

1999-01-01

399

75 FR 52938 - E. I. du Pont de Nemours and Company; Notice of Filing  

Federal Register 2010, 2011, 2012, 2013

...Regulatory Commission [Docket No. ER10-1810-001] E. I. du Pont de Nemours and Company; Notice of Filing August 20, 2010. Take notice that on August 20, 2010, E. I. du Pont de Nemours and Company, filed clarification and an...

2010-08-30

400

Roulement des entreprises et croissance de la productivite dans le secteur canadien du commerce de detail  

Microsoft Academic Search

La presente etude se penche sur le roulement des entreprises et sur la croissance de la productivite dans le secteur canadien du commerce de detail. Le roulement des entreprises a lieu lorsque, en raison du processus concurrentiel, des entreprises sortantes et des entreprises existantes en declin voient diminuer leur part de marche au profit des nouvelles entreprises et des entreprises

John R. Gu Wulong Baldwin

2008-01-01

401

A comparison of human exposure to natural radiation and DU in parts of the Balkan region  

Microsoft Academic Search

The paper presents the field results from six selected rural communities in the Southeast (Kalna), South (Niska Banja, Gornja Stubla, Borovac) and West (Uzice, Han Pijesak) parts of the Balkan region, where general population exposures to unmodified and technologically enhanced natural radioactive material (TENORM), including ammunition containing depleted uranium (DU) or reprocessed DU as well as indoor high radon, have

Z. S. Zunic; K. Fujimoto; I. V. Yarmoshenko

2005-01-01

402

Bilan de l'emploi en 1973, année médiane du VIe Plan  

Microsoft Academic Search

[fre] Bilan de l'emploi en 1973, année médiane du VIe Plan par Bruno DURIEUX . Année de forte activité économique, 1973 restera caractérisée par un haut niveau de croissance de la production intérieure brute, une forte progression des emplois et une stabilisation du chômage. Le bilan de l'année laisse cependant apparaître deux importants sujets de préoccupation : les tensions sur

Bruno Durieux

1974-01-01

403

Modulation des aides, renforcement du deuxième pilier et répartition des subventions et des revenus agricoles  

Microsoft Academic Search

Ce texte présente trois scénarios de modulation des aides du premier pilier en vue de renforcer le deuxième pilier. Compte tenu du poids des aides dans le revenu, une redistribution plus égalitaire des subventions ne correspond pas automatiquement à une nette baisse de l’inégalité des revenus. La répartition des revenus dépend aussi très largement de l’évolution des prix relatifs des

Jean-Pierre Butault; Jean-Marc Rousselle

2007-01-01

404

Privatisation et dévolution des pouvoirs : le modèle français du gouvernement d'entreprise  

Microsoft Academic Search

[fre] Le propos de cet article est de caractériser le modèle français du corporate governance à la fois sur un plan théorique, mais aussi sur un plan très pratique. Du point de vue conceptuel, on montre qu'il est possible de ranger le modèle français plutôt dans une approche théorique non standard que standard. En France, la gouvernance d'entreprise est en

François Morin

1996-01-01

405

Influence des interactions du couple ciment/adjuvant dispersant sur les proprietes des betons: Importance du mode d'introduction des adjuvants  

NASA Astrophysics Data System (ADS)

Les travaux de recherche de cette these de doctorat ont porte sur les phenomenes d'incompatibilite (ou de compatibilite) ciment/adjuvant dispersant en mettant l'accent sur l'influence du mode d'introduction des adjuvants sur les proprietes des betons frais et durcis. Les aspects physiques et chimiques de l'interaction ciment/adjuvant a ete relies aux proprietes des betons en tenant compte du rapport E/C, de la teneur en C3A du ciment ainsi que du type d'adjuvant dispersant. Le programme experimental propose debute par une etude rheologique et mecanique sur pate et sur beton. Le comportement du superplastifiant a base de polynaphtalene (PNS) depend surtout de son interaction avec les premiers produits d'hydratation du ciment. Cette interaction du superplastifiant PNS avec le ciment est remarquablement differente dans le cas ou l'ajout du PNS est differe de quelques minutes. Lorsque le superplastifiant PNS est introduit directement avec l'eau de gachage, on remarque la formation d'un gel blanc compose d'ettringite, de CaCO 3 et de polynaphtalene et ce compose organo-mineral est presque inexistant lorsque le superplastifiant PNS est ajoute en mode differe. Ce gel organo-mineral se forme a partir de la solution entre les aluminates de calcium hydrates, les sulfates et le PNS, et est responsable de la perte d'affaissement du beton. Les analyses au microscope electronique a balayage montrent que l'introduction du superplastifiant PNS en mode S1 (ajout direct) engendre la precipitation d'une plus grande quantite d'ettringite et de produit organo-mineral. Cette ettringite finement cristallisee, abondante et enchevetree aura pour consequence de diminuer les proprietes rheologiques des betons et des pates. Ce phenomene ne s'observe pas lorsque le superplastifiant PNS est introduit en mode differe. Le mode d'introduction du superplastifiant a base de polyacrylate (PAE) n'affecte nullement le comportement rheologique du beton. Par ailleurs, le gel organo-mineral n'apparait pas avec le superplastifiant PAE. Le superplastifiant PNS et son adsorption n'est pas fonction de la teneur en C3A. Un resultat tres important est la concentration en calcium qui est beaucoup plus elevee avec le superplastifiant PNS, surtout avec le ciment a forte teneur en C3A. Il semble que l'hydratation des phases du ciment soit controlee par la presence du superplastifiant PAE. Les analyses au microscope electronique a balayage avec le superplastifiant a base de polyacrylate apres 60 minutes d'hydratation du ciment montre de facon tres nette que la surface des grains de ciment est denudee de tout produit d'hydratation. En ce qui concerne les reducteurs d'eau, l'ajout en mode differe produit un certain effet benefique sur la rheologie et depend aussi du dosage surtout avec le reducteur d'eau de portee moyenne a base de lignosulfonate modifie (LM). Dans tous les cas, le reducteur d'eau ordinaire CG retarde plus la prise que le reducteur d'eau de portee moyenne LM. (Abstract shortened by UMI.)

Baalbaki, Moussa

406

Spectroscopie DU Furanne et DU Thiophene Par Diffusion Inelastique D'electrons  

NASA Astrophysics Data System (ADS)

Nous avons etudie les molecules de furanne ( rm C_4H_4O) et de thiophene (rm C_4H_4O) au moyen de la spectroscopie de diffusion inelastique d'electrons. Pour (rm C_4H_4O), les spectres realises dans differentes conditions d'energie d'impact et d'angle de diffusion contiennent des singularites ou des families de pics correspondant a: (1) des vibrations de l'etat fondamental dans le domaine 0-0.5 eV, (2) des etats triplets ^3 B_1 et ^3 A_1 qui dominent la region 3-5.5 eV, (3) des etats de valences, entre 5 et 10 eV, dont certains son accompagnes de progressions vibrationnelles, soit ~ A _1B_2, ~ B ^1A_1 et ~ C ^1A_1, (4) toujours entre 5 et 10 eV, deux series de Ryhdberg (rm 1a_2to nda_2 et rm 1a_2to npb_2) qui convergent vers la premiere limite d'ionisation de la molecule, avec une progression vibrationnelle associee au mdoe nu_4 pour la seconde, et une troisieme serie (rm 2b_1to nsa_1 ) convergent vers la seconde limite d'ionisation accompagnee de la progression de mode nu _1. Pour rm C_4H_4S, nos spectres presentent les memes etats de vibration et les memes etats triplets que pour rm C_4H _4O. Nous avons releve egalement, dans la region de 5 a 10 eV, des etats de valence ~ A ^1A_1 (ou ~ A ^1B_2), ~ B ^1A_1 (ou ~ B ^1B _2) et ~ C ^1A_1 (ou ~ C ^1B_2). Pour la premiere fois, par la spectroscopie de diffusion inelastique d'electrons, de nombreux pics ont ete identifies et attribues, dans le cadre de ce travail. Il s'agit, notamment, des etats de vibration de l'etat electronique fondamental de ces molecules et egalement de certains etats de Rydberg dans le cas du furanne.

Lotfi, Said

407

THE TRAINING OF AGRICULTURAL CREDIT STAFF IN NIGERIA: AN INSIGHT \\/ LA FORMATION DU PERSONNEL DANS LE SECTEUR DU CREDIT AGRICOLE AU NIGERIA: UN APPROFONDISSEMENT  

Microsoft Academic Search

Le manque de personnel qualifié et d'activité de formation professionnelle constitue l'obstacle le plus important de l'amélioration efficace de la régulation du secteur agricole en particulier en ce qui concerne l'activité du crédit agricole dans les pays en voie de développement. Partant de cette constatation, cet article analyse la nature des possibilités de formation offertes à un échantillon de fonctionnaires

Olufemi Oludimu

1984-01-01

408

Vers une proposition d'integration de l'approche objective et subjective de la situation d'achat dans l'etude du comportement du consommateur  

Microsoft Academic Search

Si l'influence de la situation d'achat sur le comportement du consommateur est admise, les problèmes quant au choix d'une mesure objective ou subjective de cette variable se posent toujours. Dans le but de montrer que l'approche objective et subjective du contexte d'achat fournissent des informations complémentaires sur les agissements de l'individu, nous avons mené une étude empirique auprès de 200

Jean-François LEMOINE

2000-01-01

409

The Nature of Evolution  

ERIC Educational Resources Information Center

The nature of evolution, the historical change in the universe, and the change that is caused by the workings of the dynamic processes at the smallest and largest scales are studied. It is viewed that the cumulative change in the historical systems is caused by evolution, which is a type of causal relationship and evolutionary processes could be…

Alles, David L.

2005-01-01

410

Evolution: Theory or Dogma?  

ERIC Educational Resources Information Center

In this paper the author examines the question of whether evolution is a theory or a dogma. He refutes the contention that there is a monolithic scientific conspiracy to present evolution as dogma and suggests that his own presentation might be more appropriately entitled "Creationism: Theory or Dogma." (PEB)

Mayer, William V.

411

Manipulation of Quantum Evolution.  

National Technical Information Service (NTIS)

The free evolution of a non-relativistic charged particle is manipulated using time-dependent magnetic fields. It is shown that the application of a programmed sequence of magnetic pulses can invert the free evolution process, forcing an arbitrary wave pa...

D. J. F. Cabera, B. Mielnik

1994-01-01

412

Voices for Evolution  

NSDL National Science Digital Library

This National Center for Science Education webpage includes statements from many religious organizations voicing tolerance for the theory of evolution as an explanation for the origin of life. Different faiths take different approaches to evolution versus creationism, but most affirm the responsibility of professional educators to make final decisions about the public school curriculum.

The National Center For Science Education, Inc.

413

State Standards and Evolution  

ERIC Educational Resources Information Center

Throughout the United States various individuals and groups have tried to subvert science education by removing or weakening the treatment of evolution in state science-education standards. Most states' science-education standards support the teaching of evolution, but many in the general public and some policymakers want science classrooms to…

Moore, Randy

2004-01-01

414

Framing Evolution Discussion Intellectually  

ERIC Educational Resources Information Center

This study examines how a first-year biology teacher facilitates a series of whole-class discussions about evolution during the implementation of a problem-based unit. A communicative theoretical perspective is adopted wherein evolution discussions are viewed as social events that the teacher can frame intellectually (i.e., present or organize as…

Oliveira, Alandeom W.; Cook, Kristin; Buck, Gayle A.

2011-01-01

415

Evolution for Young Victorians  

ERIC Educational Resources Information Center

Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's "Origin of Species." Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented…

Lightman, Bernard

2012-01-01

416

Evolution & Intelligent Design  

ERIC Educational Resources Information Center

Advocates of Intelligent Design (ID) theory argue that evolution is a theory in crisis, ID is a legitimate scientific theory, and biology teachers should teach the controversy. Supporters of evolutionary theory testify that ID is a religious, not scientific, concept, and evolution is in no danger of bankruptcy, having survived 140 years of…

Staver, John R.

2003-01-01

417

Supply chain contract evolution  

Microsoft Academic Search

Summary This paper draws together theories from organisational and neo-institutional literatures to address the evolution of supply chain contracts. Using a longitudinal case study of the Norwegian State Railways, we examine how firms move through the stages in an inter-organisational process of supply chain contract evolution and how they can cooperate to ensure efficiency and equity in their contractual relationship.

Tim Coltman; Kathrine Bru; Nidthida Perm-Ajchariyawong; Timothy M. Devinney; Gabriel R. G. Benito

2009-01-01

418

Evolution Under Attack  

ERIC Educational Resources Information Center

The article points out the growing attempts by creationists to have special creation presented with evolution in any educational discussion of the origin of life. The evolution theory is shown to be consistent with known scientific facts while the theory of special creation does not adequately account for these facts. (LS)

Muench, David; Newell, Norman D.

1974-01-01

419

Type Ia supernova SN 2003du: optical observations  

Microsoft Academic Search

UBVRI photometry and optical spectra of type Ia supernova SN 2003du obtained\\u000aat the Indian Astronomical Observatory for nearly a year since discovery are\\u000apresented.\\u000a The apparent magnitude at maximum was B=13.53 +\\/- 0.02 mag, and the colour\\u000a(B-V) = -0.08 +\\/- 0.03 mag. The luminosity decline rate, Delta(m_{15}(B)) =\\u000a1.04 +\\/- 0.04 mag indicates an absolute B magnitude at

G. C. Anupama; D. K. Sahu; J. Jose

2004-01-01

420

Evolution : Online Lessons for Students: Learning Evolution  

NSDL National Science Digital Library

These seven online lessons provide multimedia pathways to help students understand evolution and the nature of science. Each lesson focuses on an essential question and contains two to three engaging activities. The website includes both student lessons and teacher pages for each topic.

2001-01-01

421

Organic chemical evolution  

NASA Technical Reports Server (NTRS)

The course of organic chemical evolution preceding the emergence of life on earth is discussed based on evidence of processes occurring in interstellar space, the solar system and the primitive earth. Following a brief review of the equilibrium condensation model for the origin and evolution of the solar system, consideration is given to the nature and organic chemistry of interstellar clouds, comets, Jupiter, meteorites, Venus and Mars, and the prebiotic earth. Major issues to be resolved in the study of organic chemical evolution on earth are identified regarding condensation and accretion in the solar nebula, early geological evolution, the origin and evolution of the atmosphere, organic production rates, organic-inorganic interactions, environmental fluctuations, phase separation and molecular selectivity.

Chang, S.

1981-01-01

422

Analyse numérique du problème de déplacement du noyau fondu en soudage par points de tôles à différentes épaisseurs  

NASA Astrophysics Data System (ADS)

Le soudage par résistance par points est une technique d'assemblage très répandue, en particulier dans l'industrie automobile, parce qu'elle est rapide, fiable et bon marché. Pour cela, la réalisation d'un point de soudure de qualité reste encore une préoccupation de l'industrie, surtout lorsqu'il s'agit de souder des tôles à différentes épaisseurs. Les premiers modèles mathématiques et expérimentaux qui couvrent ces différents aspects, sont principalement dirigés vers les modèles de transfert de chaleur ou vers les phénomènes de surfaces (modèles de surfaces) ; ces derniers, sont un problème d'importance, puisqu'ils interviennent chaque fois qu'un transfert de chaleur s'effectue entre deux solides accolés. Les physiciens ont étudie expérimentalement la réponse de la région de contact de deux solides aux pulsations de courant. Ils ont montré que le contact possède une résistance de resserrement due aux aspérités de surface, et que la température moyenne à l'interface des deux solides sous un chargement uniforme produit un adoucissement local lequel fait augmenter la région de contact. Le but de ce travail est consacré à l'analyse de l'influence des épaisseurs de tôles sur la position du noyau fondu. Expérimentalement, il a été montré que lorsque le rapport des épaisseurs est compris entre 1/1 et 1/10, le noyau fondu se déplace vers la pièce la plus épaisse. Ce phénomène peut s'expliquer à partir d'une étude thermique. Nous proposons donc, de résoudre le problème de transfert thermique transitoire associé au processus de soudage par points moyennant une méthode numérique. Ce modèle est capable de prédire l'évolution du noyau fondu en fonction des paramètres du procédé à savoir l'intensité de soudage et temps de soudage, ainsi que la répartition thermique en chaque point de l'assemblage.

Benkedda, Y.; Tahar Chaouch, K.; Ibrir, B.

2005-05-01

423

The Creation/Evolution Continuum.  

ERIC Educational Resources Information Center

Many believe that creation and evolution are two totally different theories. Encourages rejection of the creation/evolution dichotomy and recognition of the creation/evolution continuum. (Contains 19 references.) (ASK)

Scott, Eugenie C.

2001-01-01

424

Amélioration des performances d'une implantation parallélovectorielle du gradient conjugué par extension du schéma de stockage matriciel  

NASA Astrophysics Data System (ADS)

Electromagnetic field computation with the Finite Element (FE) method implies solving of large linear systems of equations. Performances and memory capacities of today computers allow to achieve three-dimensional FE discretizations of electromagnetic problems, but the number of unknowns grows high. So, to improve time to the numerical solution of the linear system(s) thus arising, the use of parallel and/or vector computers has to be envisaged. In this paper, the main constitutive steps of the Pre-conditioned Conjugate Gradient algorithm (PCG) are analysed. After a short recall of our previous work concerning their improvement by use of vector and parallel computations, we show some speedup limitations due to the sparse row-wise matrix storage scheme employed. Then, an extension of this matrix representation is proposed, leading to introduce redundant storage of non-zero coefficients. In spite of the “memory waste” thus implied, it is shown how this extension can be successfully employed to increase the speedup due to parallelism and vectorization on the whole algorithm, and in particular to derive a parallel preconditioner. La résolution par la méthode des éléments finis des équations de l'électromagnétisme conduit à résoudre de grands systèmes d'équations linéaires. Les capacités mémoire et les performances actuelles des systèmes informatiques permettent de traiter les problèmes électromagnétiques par discrétisation tridimensionnelle, mais alors le nombre d'inconnues devient très élevé. Ainsi, la résolution en un temps raisonnable des équations linéaires associées à de telles discrétisations conduit à envisager l'emploi d'ordinateurs à architecture parallèle. Dans cet article, les différentes étapes constitutives de l'algorithme du gradient conjugué préconditionné (GCP) sont analysées. Après un court rappel de nos travaux antérieurs concemant leur amélioration par utilisation de traitements parallèles et vectoriels, nous montrons les limitations du gain de temps dues au mode de stockage matriciel utilisé : la représentation creuse dite “Morse”. Nous proposons alors une extension de ce mode de stockage, conduisant à l'introduction de redondance au niveau du rangement des termes matriciels en mémoire. Malgré le “gaspillage” mémoire ainsi occasionné, il apparait que cette extension peut être mise à profit pour augmenter sensiblement les gains par parallélisation et vectorisation de l'ensemble de l'algorithme du gradient conjugué, et notamment pour la réalisation d'un pré-conditionnement parallèle.

Magnin, H.; Coulomb, J. L.

1993-03-01

425

Carcinome collo?de du sein: ? propos d'un cas  

PubMed Central

Nous rapportons le cas d'une tumeur colloïde du sein chez un homme. Cette situation rare interpelle par son mode de découverte. Nous avons pris en charge un homme de 60 ans atteint d'une lésion rétro-aréolaire droite classée cliniquement T4b N1 M0 et suspecte radiologiquement. L'analyse histologique (microbiopsie) a conclu à un carcinome colloïde muqueux associé à une petite composante canalaire classique de grade I de SBR du sein. Les traitements complémentaires associent mastectomie, curage, chimiothérapie, radiothérapie et hormonothérapie. Le cancer du sein est rare chez l'homme. Le carcinome colloïde est exceptionnel puisqu'il représente seulement 1 à 6% de l'ensemble des cancers du sein. Il est encore plus rare chez l'homme. Ces tumeurs touchent une population spécifique et ont un meilleur pronostic que les autres types prépondérant dans les cancers du sein chez l'homme. A travers cette observation et une revue de la littérature, nous essaierons de discuter les principales caractéristiques anatomo-cliniques et évolutives de cette forme rare du cancer du sein.

Laabadi, Kamilia; Jayi, Sofia; Alaoui, Fatimazohra Fdili; Bouguern, Hakima; Chaara, Hikmat; Melhouf, My Abdelilah

2013-01-01

426

Kyste hydatique du foie rompu dans la veine cave inf?rieure  

PubMed Central

La rupture du kyste hydatique dans la veine cave inférieure est une complication rare et grave des kystes hydatiques hépatique. La manifestation la plus fréquente est l'embolie pulmonaire. L'hémorragie aigue intra-kystique survienne surtout en per-opératoire et elle est d’évolution dramatique. Le diagnostic est basé sur le scanner. Le traitement est chirurgical. Nous rapportons un cas clinique rare chez un patient de 38 ans, opéré en urgence pour un sepsis sur un kyste hydatique du foie comprimant la veine cave inférieur (VCI) avec thrombose partielle de cette dernière. Après évacuation du kyste, une fistulisation spontané per opératoire s'est produite dans la VCI ayant causé le décès du patient. La rupture du kyste hydatique du foie dans la VCI doit toujours être redoutée devant un kyste hydatique des segments postérieurs du foie droit (VII et VIII), comprimant la VCI avec présence en son sein d'une thrombose ou des vésicules filles. Le traitement chirurgical doit être réalisé avec prudence et toujours sous contrôle vasculaire.

Laalim, Said Ait; Ibn Majdoub Hassani, Karim; Toughai, Imane; Oussaden, Abdelmalek; Kamaoui, Imane; Mazaz, Khalid; Taleb, Khalid Ait

2011-01-01

427

Evolution of vaporizing pulsars  

NASA Technical Reports Server (NTRS)

We construct evolutional scenarios for LMXB's using a simplified stellar model. We discuss the origin and evolution of short-period, low mass binary pulsars with evaporating companions. We suggest that these systems descend from low-mass X-ray binaries and that angular momentum loss mainly due to evaporative wind drives their evolution. We derive limits on the energy and angular momentum carried away by the wind based on the observed low eccentricity. In our model the companion remains near contact, and its quasiadiabatic expansion causes the binary to expand. Short-term oscillations of the orbital period may occur if the Roche-lobe overflow forms an evaporating disk.

Mccormick, P.

1994-01-01

428

Evolution of biological complexity  

PubMed Central

To make a case for or against a trend in the evolution of complexity in biological evolution, complexity needs to be both rigorously defined and measurable. A recent information-theoretic (but intuitively evident) definition identifies genomic complexity with the amount of information a sequence stores about its environment. We investigate the evolution of genomic complexity in populations of digital organisms and monitor in detail the evolutionary transitions that increase complexity. We show that, because natural selection forces genomes to behave as a natural “Maxwell Demon,” within a fixed environment, genomic complexity is forced to increase.

Adami, Christoph; Ofria, Charles; Collier, Travis C.

2000-01-01

429

Selection and the Evolution of Industry  

Microsoft Academic Search

Recent evidence shows that within an industry, smaller firms grow\\u000d\\u000a\\u0009faster and are more likely to fail than large firms. This paper provides\\u000d\\u000a\\u0009a theory of selection with incomplete information that is consistent\\u000d\\u000a\\u0009with these and other findings. Firms learn about their efficiency\\u000d\\u000a\\u0009as they operate in the industry. The efficient grow and survive;\\u000d\\u000a\\u0009the inefficient decline and fail. A

Boyan Jovanovic

1982-01-01

430

Le schwannome malin du nerf grand sciatique chez l'enfant  

PubMed Central

Le schwannome malin est une tumeur très rare chez l'enfant (1 à 2% des tumeurs des tissus mous), elle se développe au dépend des cellules de schwanne. Dans ce travail, les auteurs rapportent un cas de schwannome malin développé au dépend du nerf grand sciatique. La radiographie de la cuisse de face et de profil était normale. L'imagerie par résonance magnétique a identifié une lésion le long du trajet du nerf grand sciatique. La tumeur a été réséquée en totalité emportant le nerf grand sciatique. L'examen anatomo-pathologique a confirmé le diagnostic.

Lechqar, Maryem; Elbiache, Imad; Atarraf, Karima; Bouabdellah, Youssef; Afifi, My Abderahman

2012-01-01

431

Health departments in the U.S. 1920-1988: statements of mission with special reference to the role of C.-E.A. Winslow.  

PubMed Central

The mission of local health departments in the U.S. is traced from the 1920s to the present through examination of official promulgations of the American Public Health Association and other organizations. As the communicable diseases came under general control, this mission was conceived more broadly. Nevertheless, in effect their public health role was diminished due to the rapid ascendancy of private and not-for-profit medical care, which consistently sought to keep public health out of potential areas of competition. Thinking both within the public health field (as represented by C.-E.A. Winslow) and outside the public health field (as represented by the American Medical Association), had created boundaries limiting public health's role to preventive medical services. This restriction, in turn, largely excluded the public health field from participation in the tremendous expansion of medical care since World War II. The public health role was further limited in 1970 by the removal of much of environmental pollution from its purview. The sum of these and other forces has left the public health field weakened and in considerable confusion about its role at a time when the resurgence of infectious disease (e.g., AIDS and Lyme disease), environmental hazards, and medical care institutions requires a strong public health presence.

Jekel, J. F.

1991-01-01

432

International Fusion Materials Irradiation Facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization.  

PubMed

In the framework of the ITER broader approach, the International Fusion Materials Irradiation Facility (IFMIF) deuteron accelerator (2 × 125 mA at 40 MeV) is an irradiation tool dedicated to high neutron flux production for future nuclear plant material studies. During the validation phase, the Linear IFMIF Prototype Accelerator (LIPAc) machine will be tested on the Rokkasho site in Japan. This demonstrator aims to produce 125 mA/9 MeV deuteron beam. Involved in the LIPAc project for several years, specialists from CEA/Saclay designed the injector based on a SILHI type ECR source operating at 2.45 GHz and a 2 solenoid low energy beam line to produce such high intensity beam. The whole injector, equipped with its dedicated diagnostics, has been then installed and tested on the Saclay site. Before shipment from Europe to Japan, acceptance tests have been performed in November 2012 with 100 keV deuteron beam and intensity as high as 140 mA in continuous and pulsed mode. In this paper, the emittance measurements done for different duty cycles and different beam intensities will be presented as well as beam species fraction analysis. Then the reinstallation in Japan and commissioning plan on site will be reported. PMID:24593497

Gobin, R; Bogard, D; Cara, P; Chauvin, N; Chel, S; Delferrière, O; Harrault, F; Mattei, P; Mosnier, A; Senée, F; Shidara, H; Okumura, Y

2014-02-01

433

The bispecific immunoligand ULBP2-aCEA redirects natural killer cells to tumor cells and reveals potent anti-tumor activity against colon carcinoma.  

PubMed

NKG2D, an activating receptor expressed on NK cells and T cells, is critically involved in tumor immunosurveillance. In this study, we explored the potential therapeutic utility of the NKG2D ligand ULBP2 for the treatment of colon carcinoma. To this end we designed a fusion protein consisting of human ULBP2 and an antibody-derived single chain targeting the tumor carcinoembryonic antigen (CEA). The bispecific recombinant fusion protein re-directed NK cells towards malignant cells by binding to both, tumor cells and NK cells, and triggered NK cell-mediated target cell killing in vitro. Moreover, tumor growth was significantly delayed in a syngeneic colon carcinoma mouse model in response to immunoligand treatment. The anti-tumor activity could be attributed to the stimulation of immune cells with an elevated expression of the activation marker CD69 on NK, T and NKT cells and the infiltration of CD45+ immune cells into the solid tumor. In summary, it was demonstrated that immunoligands provide specific tumor targeting by NK cells and exert anti-tumor activity in vitro and in vivo. This technology represents a novel immunotherapeutic strategy for solid tumors with the potential to be further developed for clinical applications. PMID:24242212

Rothe, Achim; Jachimowicz, Ron D; Borchmann, Sven; Madlener, Marie; Keßler, Jörg; Reiners, Katrin S; Sauer, Maike; Hansen, Hinrich P; Ullrich, Roland T; Chatterjee, Sampurna; Borchmann, Peter; Yazaki, Paul; Koslowsky, Thomas C; Engert, Andreas; Heukamp, Lukas C; Hallek, Michael; von Strandmann, Elke Pogge

2014-06-15

434

Evaluation of the use of decision-support software in carcino-embryonic antigen (CEA)-based follow-up of patients with colorectal cancer  

PubMed Central

Background The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC) patients. This system gathers Carcino-Embryonic Antigen (CEA) values and automatically returns a recommendation based on the latest values. Methods Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed. Results 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme. Conclusion CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

2012-01-01

435

The evolution of Lua  

Microsoft Academic Search

We report on the birth and evolution of Lua and discuss how it moved from a simple configuration language to a versatile, widely used language that supports extensible semantics, anonymous functions, full lexical scoping, proper tail calls, and coroutines.

Roberto Ierusalimschy; Luiz Henrique De Figueiredo; Waldemar Celes Filho

2007-01-01

436

Evolution: Always New  

ERIC Educational Resources Information Center

The changes in the evolution due to changes in science are explored. These changes are frustrating to paleontologists, especially when they are trying to date a singular event, like a cataclysm that precipitated a mass extinction.

Flannery, Maura C.

2005-01-01

437

Evolution of bacterial genomes.  

PubMed

This review examines evolution of bacterial genomes with an emphasis on RNA based life, the transition to functional DNA and small evolving genomes (possible plasmids) that led to larger, functional bacterial genomes. PMID:9111921

Trevors, J T

1997-03-01

438

The evolution of galaxies  

NASA Technical Reports Server (NTRS)

The recent observational evidence on the evolution of galaxies is reviewed and related to the framework of current ideas for galaxy formation from primordial density fluctuations. Recent strong evidence for the evolution of the stellar population in ellipticals is presented, as well as evidence that not all ellipticals behave as predicted by any simple theory. The status of counts of faint galaxies and the implications for the evolution of spirals is discussed, together with a discussion of recent work on the redshift distribution of galaxies at faint magnitudes and a spectroscopic investigation of the Butcher-Oemler blue cluster galaxies. Finally a new picture for the formation and evolution of disk galaxies which may explain most of the features of the Hubble sequence is outlined.

Gunn, J. E.

1982-01-01

439

Co-Evolution.  

ERIC Educational Resources Information Center

Discusses the role of techniques of DNA analysis in assessing the genetic relationships between various species. Focuses on wolf-dog evolution using DNA evidence and historical data about human/wolf-dog relationships. (DDR)

McGhee, Robert

2002-01-01

440

Resources for Teaching Evolution  

ERIC Educational Resources Information Center

A study was done to help teachers assist students in understanding the nature of science and evolution better. The study revealed that teacher-student interaction helps the students to enhance their knowledge and ability to proceed and succeed.

Wuerth, Mary

2004-01-01

441

Lactase evolution module  

NSDL National Science Digital Library

After reviewing the case scenario and research articles, students will run the microarray simulation and use the results to formulate questions regarding molecular evolution of lactase and related genes.

Karen Klyczek (Univesrity of Wisconsin-- River Falls;); Mark Bergland (University of Wisconsin-- River Falls;); Catherine Dinitra White White (North Carolian A&T State University;); Chi-Cheng Lin (Winowna State University;); Arlin Toro (Universidad Interamericana de Puerto Rico;)

2007-06-17

442

Ontology Evolution: Not the Same as Schema Evolution  

Microsoft Academic Search

As ontology development becomes a more ubiquitous and collaborative process, ontology versioning and evolution becomes an important area of ontology research. The many similarities between database-schema evolution and ontology evolution will allow us to build on the extensive research in schema evolution. However, there are also important differences between database schemas and ontologies. The differences stem from different usage paradigms,

Natalya Fridman Noy; Michel C. A. Klein

2004-01-01

443

TD-SCDMA Evolution  

Microsoft Academic Search

This article focuses on the evolutional strategies (which can be divided into four phases) from the current commercial time division-synchronous code division multiple access (TD-SCDMA) to the future International Mobile Telecommunications (IMT)Advanced systems. The first evolutional phase is to develop an N-frequency technology to improve capacity and ease network planning of the current TD-SCDMA system. Singleand multicarrier high-speed packet access

Mugen Peng; Wenbo Wang; Hsiao-Hwa Chen

2010-01-01

444

Foresight in cultural evolution  

Microsoft Academic Search

Critics of Darwinian cultural evolution frequently assert that whereas biological evolution is blind and undirected, cultural\\u000a change is directed or guided by people who possess foresight, thereby invalidating any Darwinian analysis of culture. Here\\u000a I show this argument to be erroneous and unsupported in several respects. First, critics commonly conflate human foresight\\u000a with supernatural clairvoyance, resulting in the premature rejection

Alex Mesoudi

2008-01-01