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1

Evolution du marché et des structures de production porcine  

Microsoft Academic Search

[fre] Depuis 1966 une enquête annuelle auprès des élevages de porc permet de suivre pas à pas l'évolution des structures de production dans le secteur « porc ». Sous l'impulsion du Plan de Rationalisation démarré en 1969, l'amélioration des structures de production s'accélère, elle est vraisemblablement aujourd'hui meilleure en France qu'en R.F.A. En outre, les régions Bretagne et Nord présentent

M. Linguenheld

1971-01-01

2

Evolution du salaire des cadres supérieurs en fonction de l'âge  

Microsoft Academic Search

[fre] Parmi les salariés, une différenciation importante résulte du fait que le salaire des ingénieurs et cadres croît avec l'âge, alors que celui des ouvriers tend plutôt à décroître à partir de la trentaine. L'article « Evolution des salaires des cadres supérieurs en fonction de 1'âge » a pour but d'étudier, à partir des statistiques disponibles en France, la relation

Guy Roustang

1971-01-01

3

L'evolution de la technologie spatiale et son impact economique: Reflexion sur la transposition du modele europeen aux pays du tiers-monde  

NASA Astrophysics Data System (ADS)

La technologie spatiale s'est progressivement révélée comme un centre de propulsion technologique et économique pour les pays industriels qui ont pris partie dans l'effort de financement du programme spatial. La question que nous devons nous poser est de savoir dans quelle mesure le savoir et l'expérience accumulés lors du processus de production de cette technologie peut servir d'exemple à la forme de propagation du progrès économique pour les pays en voie de développement.

Cohendet, Patrick; Zuscovitch, Ehud

4

How Packaging Fleet Renewal Fits French CEA Programs  

SciTech Connect

CEA's (French Atomic Energy Agency) packaging fleet is dedicated to transportation of test irradiated fuels, of research reactors fuels, of navy propulsion fuels, and of waste coming from and to nuclear plants or facilities. This fleet encompasses more than 30 types of casks ranging from 5 to 30 tons, with either recent designs or other dating back to the seventies. A study has been launched in order to perform a global analysis of the life expectancy of the existing CEA and COGEMA Logistics cask fleets with respect to a 2015 target, in order to anticipate its renewal, while limiting the number of type of cask. Key elements like periodical evolutions of design and transport regulations, lessons learnt of existing casks (design, approval and extensions, operational feedback, maintenance and dismantling) are taken into account in order to ensure compliance and availability of the fleet. Moreover, from design to cask delivery, including regulatory tests, safety analysis report/ CoC, and manufacturing, 3 to 5 years is needed. Therefore cask development should be taken into account earlier of invest and research's programs. The paper will address the current life expectancy study of CEA and COGEMA Logistics packaging fleet, based on lessons learnt and regulation evolution and on general R and D plans by user facilities. It will show how a comprehensive optimized fleet is made available to CEA and other customers. Such a fleet combines optimized investment and uses, thus entailing synergies for well-mastered costs of transports. (authors)

Dumesnil, J.; Malvache, P. [Commissariat a l'Energie Atomique - CEA (France); Hugon, F.C.; Sollacaro, M. [COGEMA LOGISTICS - AREVA Group (France)

2006-07-01

5

Energy bank of “Laser Megajoule” CEA project  

Microsoft Academic Search

CEA decided to realize the Megajoule Laser (LMJ) in two steps. In a first time, one laser chain will be built in the “Ligne d'Integration Laser” (LIL) at CEA CESTA. The LIL will allow components qualification before the realization of the thirty laser chains for the Megajoule Laser. CEA has consulted four companies to carry out the LMJ energy bank.

D. R. de Cervens; J. P. Marret

1999-01-01

6

CEA Studies on Halo Formation  

NASA Astrophysics Data System (ADS)

Beginning with the TRISPAL project, halo formation has been extensively studied at CEA last 10 years. Effect of mismatching, non-linear forces, resonances, longitudinal-transverse coupling, intrabeam scattering, and interaction with the residual gas have been explored. They have been studied theoretically from both analytical models and dedicated simulation codes and, for some of them, experimentally from proton beam profile measurements over a high dynamic range in a 26 periods FODO channel. Our knowledge, strongly improved through collaborations with our worldwide colleagues, has been applied to the design of several linac projects, whose last are SPIRAL2 and RX2. The goal of this presentation is to summarise the contribution of the CEA teams to the understanding of the halo formation.

Pichoff, N.; Beauvais, P.-Y.; Duperrier, R.; Haouat, G.; Lagniel, J.-M.; Uriot, D.

2003-12-01

7

Evolution et effets incitatifs des stock-options: cas du marché financier français  

Microsoft Academic Search

This paper studies the evolution and incentive effects of the stock-options allotted to the top-managers of the CAC40's 18 large companies between 1994 and 2003. A database linked to 184 plans of stock-options is used. Three periods of analysis were considered: before, during and after the financial bubble of the 1990's end. Our results show that the stock-options in France

Elmarzougui Abdelaziz

8

Evolution et sensibilité des stock-options : cas du marché français  

Microsoft Academic Search

This paper studies the evolution and incentive effects of the stock-options allotted to the top-managers of the CAC40’s 18 large companies between 1994 and 2003. A database linked to 184 plans of stock-options is used. Three periods of analysis were considered: before, during and after the financial bubble of the 1990’s end. Our results show that the stock-options in France

Abdelaziz Elmarzougui

2006-01-01

9

Evolution des émissions de polluants des voitures particulières lors du départ à froid  

Microsoft Academic Search

Evolution of pollutant emissions from passenger cars under cold start conditions. CO, CO2, HC, CH4, NOx and N2O emissions were measured on ten conventional petrol-engined passenger cars, ten vehicles equipped with a three-way catalyst, and five diesel-engined vehicles over a great number of driving cycles under hot or cold start conditions: two standardized European and American cycles, four hot cycles

Robert Joumard; Robert Vidon; Christophe Pruvost; Patrick Tassel; Gérard De Soete

1995-01-01

10

A rapid method for the determination of human CEA\\/mouse anti-CEA immune complexes in patients undergoing immunoscintigraphy  

Microsoft Academic Search

We report here on a new and quick procedure to isolate human (hu) CEA mouse anti CEA immune complexes of sera from patients admitted for immunoscintigraphy with radiolabeled monoclonal anti CEA antibody. This method employs rabbit anti mouse IgG immune affinity chromatography together with a commercial CEA-IRMA kit for the specific isolation of immune complexes. By applying this procedure we

R. P. Baum; P. Hernaiz Driever; D. Drahovsky; G. Hör

1989-01-01

11

CEA VARIABLE-THROAT VENTURI SCRUBBER EVALUATION  

EPA Science Inventory

The report gives detailed results of fractional and overall mass efficiency tests of a Combustion Equipment Associates(CEA) variable-throat venturi scrubber. The tests were performed on a full-scale scrubber used for controlling particles and SOx emissions from a pulverized-coal-...

12

Role of Carcinoembryonic Antigen (CEA) in Breast Cancer.  

National Technical Information Service (NTIS)

Carcinoembryonic antigen (CEA) is a highly glycosylated protein that is overexpressed in many human cancers including, breast cancer. Recent studies suggest that overexpression of CEA promotes tumorogenesis by inhibiting cell differentiation, and by preve...

R. K. Gaur

2004-01-01

13

Evolution du Systeme de Financement du Logement des Etats-Unis: Rappel Historique et Lecons Tirees pour les Marches Hypothecaires Emergents (Evolution of the U.S. Housing Finance System: A Historical Survey and Lessons for Emerging Mortgage Markets).  

National Technical Information Service (NTIS)

In the past 180 years, the U.S. housing finance system (HFS) has evolved from an informal/communal institutional arrangement to one of the most well-functioning and extensive financial intermediation systems in the world. This evolution did not develop in...

2004-01-01

14

EVOLUTION DE L'OCCUPATION DU SOL DE ZIGA DANS LE YATENGA ( BURKINA FASO) À PARTIR DE PHOTOS AERIENNES  

Microsoft Academic Search

Burkina Faso is affected by desertification. The study focused on land use evolution between 1952 and 1996 in the north western region of Burkina Faso. The methodology is based on the interpretation of aerial photographs of Ziga land use at three different dates. In 1952, the vegetation was important and diversified in Ziga. In 1984, the vegetation has regressed and

Hamado SAWADOGO; Nabsanna Prosper ZOMBRE; Laurent BOCK; Daniel LACROIX

2008-01-01

15

Identification of an Interferon--inducible Carcinoembryonic Antigen (CEA) CD8 T-Cell Epitope, Which Mediates Tumor Killing in CEA Transgenic Mice  

Microsoft Academic Search

This study describes a CD8 T-cell line specific for a MHC class I-restricted carcinoembryonic antigen (CEA) epitope, residues 526 -533, isolated from CEA transgenic (CEA.Tg) mice immunized with a recom- binant vaccinia-CEA vaccine. Incubation of splenocytes from the immune CEA.Tg mice with the CEA526 -533 peptide resulted in the outgrowth of low-avidity CD8 T cells, which produced IFN- and mediated

John Schmitz; Eva Reali; James W. Hodge; Arti Patel; Garland Davis; Jeffrey Schlom; John W. Greiner

16

Carcinoembryonic antigen (CEA) level, CEA ratio, and treatment outcome of rectal cancer patients receiving pre-operative chemoradiation and surgery  

PubMed Central

Background To investigate serum carcinoembryonic antigen (CEA) as a prognostic factor for rectal cancer patients receiving pre-operative chemoradiotherapy (CRT). Methods Between 2000 and 2009, 138 patients with advanced rectal cancer receiving CRT before surgery at our hospital were retrospectively classified into 3 groups: pre-CRT CEA <6?ng/ml (group L; n?=?87); pre-CRT CEA?? 6?ng/ml and post-CRT CEA <6?ng/ml (group H-L; n?=?32); and both pre- and post-CRT CEA?? 6?ng/ml (group H-H; n?=?19). CEA ratio (defined as post-CRT CEA divided by pre-CRT CEA), post-CRT CEA level and other factors were reviewed for prediction of pathologic complete response (pCR). Results Five-year disease-free survival (DFS) was better in groups L (69.0%) and H-L (74.5%) than in group H-H (44.9%) (p?=?0.024). Pathologic complete response was observed in 19.5%, 21.9% and 5.3% of groups L, H-L and H-H respectively (p?=?0.281). Multivariate analysis showed that ypN stage and pCR were independent prognostic factors for DFS and that post-CRT CEA level was independently predictive of pCR. As a whole, post-CRT CEA <2.61?ng/ml predicted pCR (sensitivity 76.0%; specificity 58.4%). For those with pre-CRT CEA ?6?ng/ml, post-CRT CEA and CEA ratio both predicted pCR (sensitivity 87.5%, specificity 76.7%). Conclusions In patients with pre-CRT serum CEA ?6?ng/ml, those with “normalized” CEA levels after CRT may have similar DFS to those with “normal” (<6?ng/ml) pre-CRT values. Post-CRT CEA level is a predictor for pCR, especially in those with pre-CRT CEA ?6?ng/ml.

2013-01-01

17

Relationship of serum CEA levels to tumour size and CEA content in nude mice bearing colonic-tumour xenografts.  

PubMed Central

The relationship of serum carcinoembryonic antigen (CEA) levels to tumour size and antigen content was studied in nude mice bearing well differentiated, mucinous human colonic-tumour xenografts. Blood samples were taken from normal nude mice and others bearing xenografts, whose size had been calculated from in vivo measurements; saline and KCl extracts were made of a proportion of these tumours. Sera and tissue extracts were assayed for CEA activity by double-antibody radioimmunoassay. Extracts were also made from the livers and spleens of tumour-bearing and normal nude mice. All normal sera and 78% of sera from tumour-bearing animals had CEA values less than 11.4 ng/ml. No clear correlation was found between serum CEA levels greater than 11.4 ng/ml and tumour size or weight, or between serum CEA and tumour CEA concentrations or total CEA burden. The concentration of CEA in those tumours tested varied from 1 to 22 microgram/g. Our results confirm and extend the conclusions reached by others (Stragand et al., 1980) studying the significance of serum CEA levels with xenograft model systems. The complexity of factors contributing to circulating CEA is discussed in the light of our findings. Images Fig. 1

Lewis, J. C.; Keep, P. A.

1981-01-01

18

CEA determination in the follow-up of extracolorectal neoplasms.  

PubMed

CEA was initially described as a tumor and organ specific colorectal antigen, but later found by more sensitive methods in other tumors (stomach, pancreas, lung, breast) and in minor amounts in inflammatory, normal adult and fetal organs of the gastrointestinal tract. The main clinical application of CEA concerns its pretherapeutic and serial determination as circulating antigen in serum and other body fluids by means of CEA-specific, commercially available test kits. By clinical studies a significant correlation has been proven between the pretherapeutic serum CEA level and tumor stages and prognosis. Moreover, serial CEA level changes have been shown a valuable monitor following operation or during radio/chemotherapy anticipating and reflecting the clinical course of disease. In combination with newly established tumor markers, the main clinical indication for CEA determination in addition to colorectal cancer concerns monitoring of patients with stomach (+CA 72-4), lung (+NSE/SCC) and breast cancer (+CA 15-3/MCA). PMID:1431341

Lamerz, R

19

The clinical usefulness of preoperative CEA determination in gastric cancer  

Microsoft Academic Search

Between 1980 and 1984, preoperative serum carcinoembryonic antigen (CEA) was determined in 468 patients with gastric cancer\\u000a to evaluate its clinical usefulness. The positive rate of preoperative CEA was 20.9 per cent in these 468 patients. A significantly\\u000a higher CEA positive rate was obtained in those patients with liver metastasis (69.2 per cent), n3–4 (40.0 per cent), stage IV gastric

Toshiro Koga; Tadashi Kano; Kuniyasu Souda; Naokata Oka; Kiyoshi Inokuchi

1987-01-01

20

Thermal evolution of magma reservoirs in the shallow crust and incidence on magma differentiation: the St-Jean-du-Doigt layered intrusion (Brittany, France)  

NASA Astrophysics Data System (ADS)

Understanding the emplacement and growth of intrusive bodies in terms of mechanism, duration, thermal evolution and rates are fundamental aspects of crustal evolution. Recent studies show that many plutons grow in several Ma by in situ accretion of discrete magma pulses, which constitute small-scale magmatic reservoirs. The residence time of magmas, and hence their capacities to interact and differentiate, are controlled by the local thermal environment. The latter is highly dependant on 1) the emplacement depth, 2) the magmas and country rock composition, 3) the country rock thermal conductivity, 4) the rate of magma injection and 5) the geometry of the intrusion. In shallow level plutons, where magmas solidify quickly, evidence for magma mixing and/or differentiation processes is considered by many authors to be inherited from deeper levels. We show however that in-situ differentiation and magma interactions occurred within basaltic and felsic sills at shallow depth (0.3 GPa) in the St-Jean-du-Doigt bimodal intrusion, France. Field evidence coupled to high precision zircon U-Pb dating document progressive thermal maturation within the incrementally built laccolith. Early m-thick mafic sills are homogeneous and fine-grained with planar contacts with neighbouring felsic sills; within a minimal 0.5 Ma time span, the system gets warmer, adjacent sills interact and mingle, and mafic sills are differentiating in the top 40 cm of the layer. Rheological and thermal modelling show that observed in-situ differentiation-accumulation processes may be achieved in less than 10 years at shallow depth, provided that (1) the differentiating sills are injected beneath consolidated, yet still warm basalt sills, which act as low conductive insulating screens, (2) the early mafic sills accreted under the roof of the laccolith as a 100m thick top layer within 0.5 My, and (3) subsequent and sustained magmatic activity occurred on a short time scale (years) at an injection rate of ca. 0.5m/y. Extraction of differentiated residual liquids might eventually take place and mix with newly injected magma as documented in active syn-emplacement shear-zones. These low-pressure differentiated liquids can potentially contribute to subaerial volcanic activity along the major shear-zones.

Barboni, M.; Bussy, F.; Ovtcharova, M.; Schoene, B.

2009-12-01

21

Souvenirs du monde des montagnes  

Microsoft Academic Search

This paper describes a particular book called Souvenirs du monde des montagnes, which draws its iconography from the history of a Swiss mountain family from 1910 to 1930. By simply dipping into the first few pages, the reader will be lost between real and virtual universes, wonder about the evolution of the images’ meanings, and question an object’s true content.

Camille Scherrer

2009-01-01

22

Souvenirs du monde des montagnes  

Microsoft Academic Search

This paper describes a particular book called Souvenirs du monde des montagnes, which draws its iconography from the history of a Swiss mountain family from 1910 to 1930. By simply dipping into the first few pages, the reader will be lost between real and virtual universes, wonder about the evolution of the images' meanings, and question an object's true content.

Camille Scherrer; Julien Pilet; Vincent Lepetit; Pascal Fua

2009-01-01

23

Amorphous silicon technology improvement at CEA-LETI  

NASA Astrophysics Data System (ADS)

The emergence of uncooled infrared detectors has opened new opportunities for IR imaging both for military and civil applications. Infrared imaging sensors that operate without cryogenic cooling have the potential to provide the military or civilian users with infrared vision capabilities packaged in a camera of extremely small size, weight and power. Uncooled infrared sensor technology has advanced rapidly in the past few years. Higher performance sensors, electronics integration at the sensor, and new concepts for signal processing are generating advanced infrared focal plane arrays. This would significantly reduce the cost and accelerate the implementation of sensors for applications such as surveillance or predictive maintenance. We present the uncooled infrared detector operation principle and the development at CEA/LETI from the 256 x 64 with a pitch of 50 micrometers to the 320 x 240 with a pitch of 35 micrometers . LETI has been involved in Amorphous Silicon uncooled microbolometer development since 1992. This silicon IR detection is now well mastered and matured so that industrial transfer of LETI technology was performed in 2000 towards Sofradir. Industrial production of 320 x 240 microbolometer array with 45micrometers pitch is then started. After a description of the technology and the methodology for reliability enhancement, we present the readout circuit architectures designs and its evolution from the 256 x 64 array to the different version of 320 x 240 arrays. Electro-optical results obtained from these IRCMOS are presented. NEDT close to 30 mK is now obtained with our standard microbolometer amorphous silicon technology.

Mottin, Eric; Bain, Astrid; Castelein, Pierre; Ouvrier-Buffet, Jean-Louis; Tissot, Jean-Luc; Yon, Jean-Jacques; Chatard, Jean-Pierre

2002-05-01

24

Evolution  

NSDL National Science Digital Library

This virtual evolution exhibit at the University of California at Berkeley (Museum of Paleontology) combines several of the best resources we've evaluated, such as Phylogenetic Systematics and the Talk Origins Archive, among others. In addition, the Evolution Website provides information on the Theory of Evolution (with links to further information including Timeline of Evolutionary Thought; Systematics; Dinosaur Discoveries; and Vertebrate Flight) and the History of Evolutionary Thought (including dozens of biographical summaries). For educators or students interested in reviewing or learning about evolution in a historical context, this Website will be of much use.

25

Analyse des lanthanides, du hafnium, du scandium, du chrome, du manganese, du cobalt, du cuivre et du zinc dans les mineraux et les roches par activation neutronique  

Microsoft Academic Search

Résumé  Pour utiliser au mieux les possibilités de l'analyse par activation et de la spectrométrie ? à l'aide des détecteurs à semi-conducteurs,\\u000a nous proposons des schémas de séparations rapides qui permettent d'effectuer les analyses de routine des lanthanides, du scandium,\\u000a du chrome, du manganèse, du cobalt, du cuivre et du zinc, dans la plupart des minéraux et des roches avec une

M. Treuil; H. Jaffrezic; N. Deschamps; C. Derre; F. Guichard; J. L. Joron; B. Pelletier; S. Novotny; C. Courtois

1973-01-01

26

The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues  

Microsoft Academic Search

The human CEA family has been fully characterized. It comprizes 29 genes of which 18 are expressed; 7 belonging to the CEA subgroup and 11 to the pregnancy specific glycoprotein subgroup. CEA is an important tumor marker for colorectal and some other carcinomas. The CEA subgroup members are cell membrane associated and show a complex expression pattern in normal and

Sten Hammarström

1999-01-01

27

Carcinoembryonic antigen (CEA) as tumor marker in lung cancer.  

PubMed

The use of CEA as a prognostic and predictive marker in patients with lung cancer is widely debated. The aim of this review was to evaluate the results from studies made on this subject. Using the search words "CEA", "tumor markers in lung cancer", "prognostic significance", "diagnostic significance" and "predictive significance", a search was carried out on PubMed. Exclusion criteria was articles never published in English, articles before 1981 and articles evaluating tumor markers in lung cancer not involving CEA. Initially 217 articles were found, and 34 were left after selecting those relevant for the present study. Four of these included both Non-Small Cell Lung Cancer (NSCLC) and Small Cell Lung Cancer (SCLC) patients, and 31 dealt solely with NSCLC patients. Regarding SCLC no studies showed that serum level of CEA was a prognostic marker for overall survival (OS). The use of CEA serum level as a prognostic marker in NSCLC was investigated in 23 studies and the use of CEA plasma level in two. In 18 (17 serum, 1 plasma) of these studies CEA was found to be a useful prognostic marker for either OS, recurrence after surgery or/and progression free survival (PFS) in NSCLC patients. Interestingly, an overweight of low stage (stage I-II) disease and adenocarcinoma (AC) patients were observed in this group. The remaining 7 studies (6 serum, 1 plasma) contained an overweight of patients with squamous carcinoma (SQ). One study found evidence for that a tumor marker index (TMI), based on preoperative CEA and CYFRA21-1 serum levels, is useful as a prognostic marker for OS in NSCLC. Six studies evaluated the use of CEA as a predictive marker for risk of recurrence and risk of death in NSCLC patients. Four of these studies found, that CEA was useful as a predictive marker for risk of recurrence and risk of death measured over time. No studies found CEA levels useful as a diagnostic marker for lung cancer. With regard to NSCLC the level of CEA measured in tumor tissue in NSCLC patients, were not of prognostic, diagnostic or predictive significance for OS or recurrence after treatment. In one study CEA level was measured in Pleural Lavage Fluid (PLF) it was here found to be useful as prognostic markers for overall survival (OS) after surgery. In conclusion serum level of CEA carries prognostic and predictive information of risk of recurrence and of death in NSCLC independent of treatment or study design. The observation that TMI index could be a potential prognostic marker for OS in NSCLC is interesting. Future studies may benefit from evaluating more than one marker at a time, which may possibly create a more precise index for prognosis and recurrence in lung cancer, than is possible by the use of single biomarkers. PMID:22153832

Grunnet, M; Sorensen, J B

2011-12-06

28

Deregulated Expression of the Human Tumor Marker CEA and CEA Family Member CEACAM6 Disrupts Tissue Architecture and Blocks Colonocyte Differentiation1  

Microsoft Academic Search

Human carcinoembryonic antigen ( CEA) and the CEA family member CEACAM6 ( formerly nonspecific cross - reacting antigen (NCA ) ) function in vitro, at least, as homotypic intercellular adhesion molecules and, in model systems, can block the terminal differentiation and anoikis of several different cell types. We have recently demonstrated that the increased cell surface levels of CEA and

Christian Ilantzis; Luisa Demarte; Robert A. Screaton; Clifford P. Stanners

2002-01-01

29

Volvulus du sigmoide necros? du postpartum  

PubMed Central

Le volvulus du sigmoïde compliquant la grossesse est une complication rare avec moins de 80 cas rapportés dans la littérature. Nous rapportons un cas de volvulus du sigmoïde compliquant les suites de couches. Une primigeste de 29-ans s'est présenté avec une douleur abdominale à J3 du post-partum. Une laparotomie exploratrice a révélé un volvulus, nécrosé, du côlon sigmoïde très distendu. Dans notre cas. Le Volvulus du sigmoïde est susceptible d'avoir été précipité par le changement rapide de la taille de l'utérus après l'accouchement. La mobilité colique associée à une distorsion du côlon sigmoïde, doit être gardé à l'esprit chez les patients qui présentent des douleurs abdominales lors du post-partum. Cet article se propose à travers un cas clinique de revoir les données de la littérature et d'engager les principes généraux de prise en charge et de traitement.

Moussaid, Ihsane; Haddad, Wafaa; Salmi, Said; Elyoussoufi, Smail; Miguil, Mohamed; Serbouti, Sihame; Boufettal, Houssine; Samouh, Naima; Berrada, Saad

2012-01-01

30

Evolution  

NASA Astrophysics Data System (ADS)

When we are looking for intelligent life outside the Earth, there is a fundamental question: Assuming that life has formed on an extraterrestrial planet, will it also develop toward intelligence? As this is hotly debated, we will now describe the development of life on Earth in more detail in order to show that there are good reasons why evolution should culminate in intelligent beings.

Peter, Ulmschneider

31

Thermal evolution of magma reservoirs in the shallow crust and incidence on magma differentiation: the St-Jean-du-Doigt layered intrusion (Brittany, France)  

Microsoft Academic Search

Understanding the emplacement and growth of intrusive bodies in terms of mechanism, duration, thermal evolution and rates are fundamental aspects of crustal evolution. Recent studies show that many plutons grow in several Ma by in situ accretion of discrete magma pulses, which constitute small-scale magmatic reservoirs. The residence time of magmas, and hence their capacities to interact and differentiate, are

M. Barboni; F. Bussy; M. Ovtcharova; B. Schoene

2009-01-01

32

Tumour lysis as a factor affecting blood levels of CEA.  

PubMed Central

A hypothesis is proposed that tumour lysis may be an important factor affecting blood levels of CEA. This has been explored in an experimental study with a model tumour system, consisting of immune-deprived mice bearing human CEA-producing tumours. Using agents such as irradiation, chemotherapeutic drugs, diphtheria toxin and techniques such as cryosurgery, it has been shown that tumour lysis is important when it is both rapid and extensive. The extent to which this may occur in patients remains uncertain, except in rare instances of dramatic response of malignant disease to treatment.

Quayle, J. B.

1982-01-01

33

Sol-gel laser coatings at CEA Limeil-Valenton  

NASA Astrophysics Data System (ADS)

CEA Limeil-Valenton has embarked in a project called 'laser megajoule' (LMJ) consisting of the construction of a 2-MJ/500- TW (351-nm) pulsed Nd:glass laser and devoted to inertial confinement fusion research in France. Room temperature and atmospheric pressure deposited sol-gel coatings for antireflective (AR), highly reflective (HR) and polarizer uses, and silicone films for environmental protection have displayed remarkable optical and laser strength performance. Such coatings can be applied onto large area and at a low cost compared to conventional vacuum deposition techniques. CEA Limeil-Valenton is also maintaining sustained efforts to promote the sol-gel technology in other areas.

Floch, Herve G.; Belleville, Philippe F.

1997-10-01

34

Le Changement linguistique: Evolution, variation, and heterogeneite. Actes du colloque de Neuchatel Universite (Neuchatel, Suisse, 2-4 Octobre 2000) (Linguistic Change: Evolution, Variation, Heterogeneity. Proceedings of the University of Neuchatel Colloquium [Neuchatel, Switzerland, October 2-4, 2000]).  

ERIC Educational Resources Information Center

|Articles in this issue focus on language evolution, variation, and heterogeneity. The following are English translations of the French article titles appearing in the issue: "Irregular Phonetic Development Due to Frequency; Regional Traits in Proto-Romance"; "Linguistic Evolution and Evolution of Perspective in the Comparative Grammar of…

Matthey, Marinette, Ed.

2001-01-01

35

Immunological Study of Carcinoembryonic Antigen (CEA) and a Related Glycoprotein  

Microsoft Academic Search

A comparison has been made of the immunological properties of CEA (carcinoembryonic antigen) and another perchloric acid-soluble macromolecule which occurs in colonic and certain other carcinomata and which is here termed CEX. By using a variety of antisera it was shown that the two substances share common antigenic groups as well as having characteristic ones of their own. These latter

D A Darcy; C Turberville; R James

1973-01-01

36

Plasma electrode Pockels cell of CEA's megajoule laser project  

Microsoft Academic Search

The large plasma electrode Pockels cell (PEPC), which has originally been developed at LLNL for high energy 4 pass laser amplifier, has been taken up in the megajoule laser project (LMJ) at CEA. Nevertheless, a few alternative technologies and methods have been taken into account to build the first prototype. The frame of both, 2 cm thick, plasma chambers have

Rene Bailly-Salins; C. Sudres; Jean-Pierre Marret

1999-01-01

37

15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).  

Code of Federal Regulations, 2013 CFR

...effective planning, site selection, design, construction, and operation...areas. (6) CEAS provides experiment design, data analysis, and data management...Atmospheric Research Program (GARP) experiments). (7) CEAS provides...

2013-01-01

38

Diagnostics d'imagerie X par microscopes X àmiroirs développés dans le cadre du programme LIL  

NASA Astrophysics Data System (ADS)

Cet article présente les premiers diagnostics d'imagerie X à base de microscopes à miroirs mis en œuvre sur la chambre d'expériences de la Ligne d'intégration Laser (LIL) implantée au CEA-CESTA. Ces diagnostics comprennent trois éléments de base : un bloc optique, qui assure les fonctions d'imagerie et de sélectivité spectrale (dans les domaines [100 eV 1 keV] et [1-5 kev]), un détecteur rapide (caméra à balayage de fente ou tube obturateur) et un système d'insertion. Ils permettent d'observer des détails inférieurs à 10 ?m sur un champ de 1 mm (ou 30 ?m SUT 3 mm) au niveau du plasma source. La qualification des microscopes sur un banc X spécifique du CEA-DIF est également décrite.

Rosch, R.; Boutin, J.-Y.; Le Breton, J. P.; Lidove, G.; Douvry, N.

2003-06-01

39

Plasmid DNA encoding human carcinoembryonic antigen (CEA) adsorbed onto cationic microparticles induces protective immunity against colon cancer in CEA-transgenic mice  

Microsoft Academic Search

A carcinoembryonic antigen (CEA)-based DNA vaccine, adsorbed onto cationic microparticles of poly(dl-lactide-co-glycolide) (PLG) induced tumor-protective immunity against a lethal challenge of MC38-CEA colon carcinoma cells in CEA-transgenic mice that was more potent than that of the corresponding naked DNA vaccine. Boosting with a plasmid encoding murine GM-CSF increased the vaccine’s efficacy leading to a complete rejection of tumor cells in

Yunping Luo; Derek O’Hagan; He Zhou; Manmohan Singh; Jeffrey Ulmer; Ralph A Reisfeld; F James Primus; Rong Xiang

2003-01-01

40

The CEA\\/CD3-Bispecific Antibody MEDI565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA  

Microsoft Academic Search

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced

Li Peng; Michael D. Oberst; Jiaqi Huang; Philip Brohawn; Chris Morehouse; Kristen Lekstrom; Patrick A. Baeuerle; Herren Wu; Yihong Yao; Steven R. Coats; William Dall’Acqua; Melissa Damschroder; Scott A. Hammond

2012-01-01

41

Sol-gel laser coatings at CEA Limeil-Valenton  

Microsoft Academic Search

CEA Limeil-Valenton has embarked in a project called 'laser megajoule' (LMJ) consisting of the construction of a 2-MJ\\/500- TW (351-nm) pulsed Nd:glass laser and devoted to inertial confinement fusion research in France. Room temperature and atmospheric pressure deposited sol-gel coatings for antireflective (AR), highly reflective (HR) and polarizer uses, and silicone films for environmental protection have displayed remarkable optical and

Herve G. Floch; Philippe F. Belleville

1997-01-01

42

Incidence du cancer du testicule en Europe  

Microsoft Academic Search

Le cancer du testicule est la tumeur la plus fréquente de l’homme jeune. L’incidence du cancer du testicule est en augmentation\\u000a depuis l’après-guerre dans la quasi-totalité des pays européens. En Europe, il existe un gradient Ouest-Est dans la région\\u000a de la mer baltique, et un gradient Nord-Sud en Europe occidentale. Le taux d’incidence a doublé dans plusieurs pays, dont\\u000a la

É. Huyghe; P.-F. Thonneau

43

The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA  

PubMed Central

MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms of CEA may affect MEDI-565 activity, we mapped the epitope of MEDI-565 on CEA using mutagenesis and homology modeling approaches. We found that MEDI-565 recognized a conformational epitope in the A2 domain comprised of amino acids 326–349 and 388–410, with critical residues F326, T328, N333, V388, G389, P390, E392, I408, and N410. Two non-synonymous single-nucleotide polymorphisms (SNPs) (rs10407503, rs7249230) were identified in the epitope region, but they are found at low homozygosity rates. Searching the National Center for Biotechnology Information GenBank® database, we further identified a single, previously uncharacterized mRNA splice variant of CEA that lacks a portion of the N-terminal domain, the A1 and B1 domains, and a large portion of the A2 domain. Real-time quantitative polymerase chain reaction analysis of multiple cancers showed widespread expression of full-length CEA in these tumors, with less frequent but concordant expression of the CEA splice variant. Because the epitope was largely absent from the CEA splice variant, MEDI-565 did not bind or mediate T-cell killing of cells solely expressing this form of CEA. In addition, the splice variant did not interfere with MEDI-565 binding or activity when co-expressed with full-length CEA. Thus MEDI-565 may broadly target CEA-positive tumors without regard for expression of the short splice variant of CEA. Together our data suggest that MEDI-565 activity will neither be impacted by SNPs nor by a splice variant of CEA.

Huang, Jiaqi; Brohawn, Philip; Morehouse, Chris; Lekstrom, Kristen; Baeuerle, Patrick A.; Wu, Herren; Yao, Yihong; Coats, Steven R.; Dall'Acqua, William; Damschroder, Melissa; Hammond, Scott A.

2012-01-01

44

Frittage du phosphate tricalcique  

NASA Astrophysics Data System (ADS)

xml:lang="fr">RésuméCe travail aborde l'étude du frittage du ? phosphate tricalcique obtenu par voie sèche, en vue d'élaborer des matériaux denses. L'évolution de la densité du matériau fritté en fonction du temps et de la température, a été suivie. Le phosphate tricalcique présente une bonne aptitude au frittage dans le domaine de température 1200 1350?°C, ainsi des taux de densification de 92% ont pu être atteints à 1300?°C. A des températures supérieures à 1350?°C, la densification est entravée par le grossissement exagéré des grains et la formation de larges pores. La diffraction des rayons X montre en plus du ? phosphate tricalcique, la présence de traces de la phase ? du phosphate tricalcique et du phosphate tétracalcique. L'analyse par résonance magnétique nucléaire du solide 31P illustre la présence de trois types de site tétraédrique. L'analyse thermique différentielle montre que les deux transformations allotropiques du phosphate tricalcique se produisent respectivement à 1285 et 1475?°C. Pour citer cet article : F. Ben Ayed et al., C. R. Physique 7 (2006).

Ben Ayed, Foued; Chaari, Kamel; Bouaziz, Jamel; Bouzouita, Khaled

2006-09-01

45

Concentration and distribution of tumor associated antigens TAG72 and CEA in stomach cancer  

Microsoft Academic Search

We measured the concentration and distribution of tumor associated antigens, TAG-72 and CEA, in stomach cancer byin vitro quantitative autoradiography (IV-QAR). Frozen sections of 33 specimens were incubated with varying concentrations of125I-labeled CEA-79.1 and B72.3 antibodies specific for carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72),\\u000a respectively. Computer analysis of specific antibody binding gave maximal binding values which were equal to

June-Key Chung; Myung-Chul Lee; Hong-Keun Chung; Sang-Moo Litvt; Ja-June Jang; Chang-Soon Koh

1995-01-01

46

Network and system diagrams revisited: Satisfying CEA requirements for causality analysis  

Microsoft Academic Search

Published guidelines for Cumulative Effects Assessment (CEA) have called for the identification of cause-and-effect relationships, or causality, challenging researchers to identify methods that can possibly meet CEA's specific requirements. Together with an outline of these requirements from CEA key literature, the various definitions of cumulative effects point to the direction of a method for causality analysis that is visually-oriented and

Anastássios Perdicoúlis; Jake Piper

2008-01-01

47

Prognostic Value of Combination Assays for CEA and CA 19–9 in Gastric Cancer  

Microsoft Academic Search

Preoperative serum CEA and CA 19-9 levels in 158 patients with gastric cancer were analyzed with respect to prognostic factors, using univariate and multivariate analysis. The incidence of high preoperative levels of both CEA and CA 19-9 was 10.1% (16\\/158). 13.9% (22\\/158) showed high CEA levels and normal CA 19-9 levels, whereas the reverse was true in 16.5% (26\\/158). Neither

Yoichi Ikeda; Haruki Oomori; Nobuhiro Koyanagi; Masaki Mori; Tatsuro Kamakura; Seizo Minagawa; Haruo Tateishi; Keizo Sugimachi

1995-01-01

48

Serum CEA testing in the post-operative surveillance of colorectal carcinoma.  

PubMed Central

Six hundred and sixty-three patients were followed with serial serum CEA measurements in addition to routine clinical surveillance after radical resection of colorectal carcinoma. Of 626 available for analysis, 366 (58.4%) remained clinically free of recurrence and had a normal CEA (less than 20 ng ml-1) throughout and 89 (14.2%) had a temporary non-progressive rise in CEA with no evidence of secondary disease. Of 171 patients who developed proven or suggestive recurrence, 114 had a preceding rise in the serum CEA and in further 21 the CEA rose simultaneously with recurrence. In 36 patients secondary disease was detected while the CEA was still within normal limits. CEA was more effective as an early index of distant metastasis, thus in 76% of those patients with a preceding rise in CEA, the secondary disease was disseminated, whereas only 20% had localised recurrence. The pattern of rise in CEA was of no practical value in distinguishing localised from distant recurrence.

Hine, K. R.; Dykes, P. W.

1984-01-01

49

Concentration and distribution of tumor associated antigens TAG-72 and CEA in stomach cancer.  

PubMed

We measured the concentration and distribution of tumor associated antigens, TAG-72 and CEA, in stomach cancer by in vitro quantitative autoradiography (IV-QAR). Frozen sections of 33 specimens were incubated with varying concentrations of 125I-labeled CEA-79.1 and B72.3 antibodies specific for carcinoembryonic antigen (CEA) and tumor-associated glycoprotein-72 (TAG-72), respectively. Computer analysis of specific antibody binding gave maximal binding values which were equal to the concentrations of the antigen or epitope. TAG-72 was detected in 25 specimens, at a concentration ranging from 8.4 to 562.9 pmol/g. CEA was detected in 32 of the 33 specimens and its concentration ranged from 8.8 to 525.3 pmol/g. The distribution of TAG-72 by IV-QAR coincided with that of the tumor cells in 41.4% of the pathologic lesions. The distribution of CEA coincided with the tumor cells in 80.5% of pathologic lesions, nearly twice the TAG-72. The concentration of TAG-72 was significantly higher in mucinous adenocarcinoma and mucin containing adenocarcinomas than other types of adenocarcinomas. There was no significant difference in the concentration of CEA among the pathologic types of stomach cancer. In summary, stomach cancer exhibited wide variations in TAG-72 and CEA expression. CEA expression was more frequent and homogeneous than TAG-72. PMID:7779533

Chung, J K; Lee, M C; Chung, H K; Lim, S M; Jang, J J; Koh, C S

1995-02-01

50

Is tissue polypeptide antigen more accurate than serum CEA for diagnosing pancreatic cancer?  

Microsoft Academic Search

Tissue polypeptide antigen (TPA) and carcinoembryonic antigen (CEA) were determined in the sera of 36 control subjects, 30 patients with pancreatic cancer, 35 with chronic pancreatitis and 25 with non-pancreatic digestive disease to evaluate their role in detecting pancreatic malignancy. Abnormal values of TPA and CEA were found in 28 and 19 of 30 patients with pancreatic cancer, and in

A Panucci; C Fabris; G Del Favero; D Basso; F Di Mario; L Marchioro; A Piccoli; M Lise; A Burlina; R Naccarato

1986-01-01

51

In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models  

SciTech Connect

Studies were performed to determine the effect of the radiolabel and circulating carcinoembryonic antigen (CEA) on the pharmacodynamics of monoclonal anti-CEA antibodies (MoAbs). The studies were performed in normal BALB/c mice and in nude mice bearing human colon tumors. Three different tumors were used, each of which produced CEA levels characteristic of that particular tumor's secretory rate. The CEJ-326 MoAb labeled with either 111In or 125I was used in all studies. Circulating CEA induced the removal of 125I and 111In MoAbs from the vascular compartment. Liver concentrations of 111In increased and 125I levels decreased as the CEA secretory rate of the tumor rose. This indicates that circulating CEA complexes form in the vascular compartment which, in an animal model, are removed by the liver and spleen. This results in decreased tumor uptake of the labeled MoAb. The iodinated MoAb complexes are dehalogenated while the 111In is retained by the liver. This dehalogenation may account for the relatively low liver activity observed in radioimmunoimaging with intact radioiodinated anti-CEA MoAbs, provided the CEA complexes are similarly removed from the vascular compartment by the human liver.

Hagan, P.L.; Halpern, S.E.; Chen, A.; Krishnan, L.; Frincke, J.; Bartholomew, R.M.; David, G.S.; Carlo, D.

1985-12-01

52

DNA Vaccines Encoding CEA and a CD40 Ligand and Methods of use Thereof.  

National Technical Information Service (NTIS)

A DNA vaccine effective for eliciting an immune response against cells that present a carcinoembryonic antigen (CEA) comprises a DNA operably encoding a CEA and a DNA operably encoding a CD40 ligand, SEQ ID NO:1 and SEQ ID NO: 2, respectively, or its homo...

R. Xiang R. A. Reisfeld

2005-01-01

53

ECRIN and MultiCusp Sources at CEA Saclay  

NASA Astrophysics Data System (ADS)

A 2.45 GHz electron cyclotron resonance test stand based on a pure volume H- negative ion production is presently running at CEA Saclay. This negative ion source (ECRIN) is working in pulsed mode, up to 10 ms at 10 Hz. Several modifications allowed increasing the extracted H- current from the source. Those results will be summed up in the first part. With the experience collected from this source, a second one using a multi-cups magnetic structure is under development. Magnetic calculations and simulations showed that an octupolar configuration could allow improving the H- ion production. Those simulations will be discussed and the new set up will also be presented. The source is now being assembled on a new test bench, called BETSI, for light ion source development based on permanent magnet structure.

Tuske, O.; Charruau, G.; Delferrière, O.; de Menezes, D.; Gobin, R.; Gauthier, Y.; Harrault, F.; Madur, A.

2007-08-01

54

ECRIN and MultiCusp Sources at CEA Saclay  

SciTech Connect

A 2.45 GHz electron cyclotron resonance test stand based on a pure volume H- negative ion production is presently running at CEA Saclay. This negative ion source (ECRIN) is working in pulsed mode, up to 10 ms at 10 Hz. Several modifications allowed increasing the extracted H- current from the source. Those results will be summed up in the first part. With the experience collected from this source, a second one using a multi-cups magnetic structure is under development. Magnetic calculations and simulations showed that an octupolar configuration could allow improving the H- ion production. Those simulations will be discussed and the new set up will also be presented. The source is now being assembled on a new test bench, called BETSI, for light ion source development based on permanent magnet structure.

Tuske, O.; Charruau, G.; Delferriere, O.; De Menezes, D.; Gobin, R.; Gauthier, Y.; Harrault, F. [Commissariat a l'Energie Atomique, CEA-Saclay, DSM/DAPNIA, 91191 Gif sur Yvette Cedex (France); Madur, A. [Synchrotron SOLEIL, l'Orme des Merisiers Saint Aubin BP48, 91192 Gif sur Yvette Cedex (France)

2007-08-10

55

Performance verification of the MIRI imager flight model at CEA  

NASA Astrophysics Data System (ADS)

MIRIM is the imager of the Mid Infrared Instrument (MIRI), one of the three scientific instruments on the James Webb Space Telescope (JWST). MIRIM will provide imaging between 5.6?m and 25.5?m, low resolution spectroscopy (LRS) between 5 and 10?m, and coronagraphy at 10.65?m, 11.4?m, 15.5?m and 23?m. The Optical bench Assembly of MIRIM Flight Model (FM) has been integrated and tested between 2008 and 2009 at CEA (Saclay, France). The tests consist in characterisation of optical performances at all wavelengths and in all three modes (imaging, spectroscopy and coronagraphy), using a test bench (or Ground Support Equipment - GSE) that has been developed for this purpose. The GSE comprises a helium cooled cryostat for the instrument itself, a proto-IR focal plane module (with JPL sensor chip and CEA electronics and housing), a warm telescope simulator that delivers a JWST-like beam, and computers and software for running automatic test procedures. It is designed to allow a large set of performance verifications, such as high-resolution PSF measurements, characterisation of coronagraphs, response to monochromatic line or resolving power of the spectroscopic mode, some of them being unique along the test program of the instrument. After a short description of the test equipment, this paper focuses on the tests results. A full assessment of performances is given. When applicable, performances are cross checked with requirements. Imaging mode and coronagraphy had already been validated on optically representative models along the MIRIM development plan, especially with the Engineering and Test Model (ETM) of MIRIM, early 2008. The FM test campaign allowed us to confirm that the flight model behaves as expected in these two modes. We also tested for the first time, and validated, the low-resolution spectroscopy mode.

Ronayette, S.; Cavarroc, C.; Kendrew, S.; Amiaux, J.; Auguères, J.-L.; Bouzat, M.; Guillard, P.; Moreau, V.; Pantin, E.; Bouchet, P.; Bensalem, A.; Orduna, T.; Lagage, P.-O.; Nehme, C.; Belu, A.; Glasse, A.; Baudoz, P.; Dubreuil, D.

2010-07-01

56

Khan Du Joe.  

National Technical Information Service (NTIS)

The video features Joe and others with learning disabilities. Having tagged himself as dumb, Joe feels alienated from classmates. Khan du encourages him to develop his abilities to compensate for his disabilities. Famous people who had learning disabiliti...

1994-01-01

57

Signal sequence deletion and fusion to tetanus toxoid epitope augment antitumor immune responses to a human carcinoembryonic antigen (CEA) plasmid DNA vaccine in a murine test system  

Microsoft Academic Search

Carcinoembryonic antigen (CEA, CEACAM5) is expressed on several human carcinomas including colon cancer. CEA contains signal peptides that target the protein through the endoplasmic reticulum and to the cell membrane. We constructed a plasmid DNA vaccine encoding a truncated CEA (?CEA), devoid of its signal peptides, and demonstrated that it was retained inside the cell, while full-length CEA (wtCEA) was

Lars H Lund; Karolina Andersson; Bartek Zuber; Anneli Karlsson; Gunnel Engström; Jorma Hinkula; Britta Wahren; Gösta Winberg

2003-01-01

58

Etude du comportement du niobium IV et du titane III dans quelques oxydes à structure en cages du type A3M8O21 I. Synthèse et evolution structurale des solutions solides Ba3Nb4+xTi4-xO21, K3Nb7+xTi1-xO21, et K3-xBaxNb8O21  

NASA Astrophysics Data System (ADS)

New solid solutions A3Nb8-xTixO21 (A = K, Ba) and K3-xBaxNb8O21 have been synthesized. They crystallize in the hexagonal A3M8O21 structure. In the series Ba3Nb4+xTi4-xO21 (0 <= x <= 4) and K3Nb7+xTi1-xO21 (0 <= x <= 1) the break in the evolution of the lattice constants observed respectively for x = 2 for the former and x = 0.5 for the latter has been interpreted as the result of the reaction Nb IV + Ti IV --> Nb V + Ti III. The better stability for the combination Nb V/Ti III in the host lattice is confirmed by the estimation of the energy levels in the structure which takes into consideration the ionization and the polarization energies.

Chailleux, J. M.; Groult, D.; Mercey, C.; Studer, F.; Raveau, B.

1981-03-01

59

Plasma electrode Pockels cell of CEA's megajoule laser project  

NASA Astrophysics Data System (ADS)

The large plasma electrode Pockels cell (PEPC), which has originally been developed at LLNL for high energy 4 pass laser amplifier, has been taken up in the megajoule laser project (LMJ) at CEA. Nevertheless, a few alternative technologies and methods have been taken into account to build the first prototype. The frame of both, 2 cm thick, plasma chambers have been cast in one piece of polycarbonate. They are refilled with He + 1 percent O2 at pressure around 1 mbar. each chamber is equipped with 20 cathodes and 20 anodes. Each cathode is in series with a 10 (Omega) ballast resistor. Each anode is in series with a 10 (Omega) or 5 (Omega) ballast resistor. The electrodes are made of solid graphite plus carbon fiber material. According to the switching function of LMJ, the KDP's electrical driver has to produce 2 pulses of amplitude V(pi ) equals 17kV, 650ns apart, with a rise and fall time of 100 ns. After a general description of this PEPC, experimental results and theoretical considerations show how we got 2 plasma electrodes with a very good homogeneity and a low resistivity since the plasma current peaks at 1400 angstrom when the 5 (mu) F energy storage capacitor is charged to 4kV. Finally, the design of the plasma current supply and the 17kV pulser is presented. The device is not quite up to scratch but, computer simulations are given.

Bailly-Salins, Rene; Sudres, C.; Marret, Jean-Pierre

1999-07-01

60

Anémie du sujet âgé  

Microsoft Academic Search

Résumé  L’anémie est fréquente chez le sujet âgé de plus de 75 ans. Les mécanismes physio-pathologiques de l’anémie sont identiques\\u000a à ceux du sujet plus jeune et l’enquête étiologique repose sur des arbres diagnostiques précis. Des facteurs de risque ont\\u000a été identifiés dans cette tranche d’âge: institutionnalisation, faible niveau socio-économique, comorbidités. Les particularités\\u000a du sujet âgé tiennent en plusieurs points:\\u000a \\u000a \\u000a \\u000a 1\\/ 

E. Pautas; T. M. Kim; A. Gouronnec; V. Siguret

2010-01-01

61

Low and Medium Level and Transuranic Waste Characterization: CEA Objectives and Experience.  

National Technical Information Service (NTIS)

The CEA studies devoted to characterization are being extended to the long term behavior. Two characterization programs of conditioned wastes (embedded wastes in cement and embedded wastes in bitumen) are reported. (ERA citation 10:012412)

B. O. Bruyere

1984-01-01

62

Building Task-Based User Interfaces with ANSI\\/CEA2018  

Microsoft Academic Search

The recently approved ANSI\\/CEA-2018 standard is motivated by the current usability crisis in computer controlled electronic products. The standard facilitates a new user interface design methodology that uses a task model at runtime to guide users.

Charles Rich

2009-01-01

63

Network and system diagrams revisited: Satisfying CEA requirements for causality analysis  

SciTech Connect

Published guidelines for Cumulative Effects Assessment (CEA) have called for the identification of cause-and-effect relationships, or causality, challenging researchers to identify methods that can possibly meet CEA's specific requirements. Together with an outline of these requirements from CEA key literature, the various definitions of cumulative effects point to the direction of a method for causality analysis that is visually-oriented and qualitative. This article consequently revisits network and system diagrams, resolves their reported shortcomings, and extends their capabilities with causal loop diagramming methodology. The application of the resulting composite causality analysis method to three Environmental Impact Assessment (EIA) case studies appears to satisfy the specific requirements of CEA regarding causality. Three 'moments' are envisaged for the use of the proposed method: during the scoping stage, during the assessment process, and during the stakeholder participation process.

Perdicoulis, Anastassios [University of Tras-os-Montes e Alto Douro, 5001-801 Vila Real (Portugal); University of Tras-os-Montes e Alto Douro, 5001-801 Vila Real (Portugal); Piper, Jake [Oxford Institute for Sustainable Development, Oxford Brookes University, Headington Campus, Gipsy, Lane, Oxford OX3 0BP (United Kingdom)

2008-10-15

64

Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein  

Microsoft Academic Search

BACKGROUND: CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. METHODS: The human MA39 scFv, selected for its ability to recognize

Emiliano Pavoni; Michela Flego; Maria Luisa Dupuis; Stefano Barca; Fiorella Petronzelli; Anna Maria Anastasi; Valeria D'Alessio; Angela Pelliccia; Paola Vaccaro; Giorgia Monteriù; Alessandro Ascione; Rita De Santis; Franco Felici; Maurizio Cianfriglia; Olga Minenkova

2006-01-01

65

Tumor Antigens CA 19.9, CA 125, and CEA in Carcinoma of the Uterine Cervix  

Microsoft Academic Search

Serum levels of carcinoembryonic antigen (CEA) and cancer antigens CA 125 and CA 19.9 were determined by immunoradiometric assay in 96 patients diagnosed of invasive carcinoma of the uterine cervix and 7 patients of cervical intraepithelial neoplasia. Elevated CEA levels were found in 33%, CA 19.9 in 32%, and CA 125 in 21.5% of invasive carcinoma patients. Specificity for each

Gloria Borras; Rafael Molina; Jordi Xercavins; Antonio Ballesta; Javier Iglesias

1995-01-01

66

Cri du Chat syndrome  

Microsoft Academic Search

Cri du Chat syndrome is a rare genetic condition affecting the short arm of chromosome 5. A range of clinical features, including the characteristic “cat-like” cry and developmental delay, is recognized in children with the syndrome. A higher incidence of certain paediatric orthopaedic conditions such as scoliosis, developmental dysplasia of the hip and pes planus and varus has also been

Lyndsay Cuming; Donna Diamond; Rouin Amirfeyz; Martin Gargan

2010-01-01

67

Extraction of CEA from tumour tissue, foetal colon and patients' sera, and the effect of perchloric acid.  

PubMed Central

The use of perchloric acid and water for the extraction of CEA from tumour and foetal tissues has been investigated. In the case of tumour, lower recoveries of CEA were obtained from perchloric acid extracts than from aqueous extracts of the same tissue. CEA has also been extracted with 3M KCl solution from insoluble perchloric acid residues of tumour homogenates and cancer patients' serum. Whilst a large proportion of CEA activity recovered from tumour was associated with the perchloric acid residue, the corresponding amounts from serum were very small. CEA elution volumes for each extract, obtained by assay of Sephadex G-200 column fractions, showed significant heterogeneity in molecular size. The purified CEA pools also showed quantitative variations in the binding profiles on Con A-Sepharose. It has been shown that perchloric acid modifies the carbohydrate in CEA, thus altering its Con A-binding properties. Preliminary experiments with foetal colon have demonstrated that, unlike colorectal CEA, a significant proportion of foetal CEA was not bound to ConA. Comparative immunodiffusion showed immunological identity of CEA from the various extracts, although the purified aqueous extract produced an additional precipitin reaction, indicating a second antigen which is relatively unstable or less soluble in perchloric acid. Images Fig. 5

Keep, P. A.; Leake, B. A.; Rogers, G. T.

1978-01-01

68

Selection, affinity maturation, and characterization of a human scFv antibody against CEA protein  

PubMed Central

Background CEA is a tumor-associated antigen abundantly expressed on several cancer types, including those naturally refractory to chemotherapy. The selection and characterization of human anti-CEA single-chain antibody fragments (scFv) is a first step toward the construction of new anticancer monoclonal antibodies designed for optimal blood clearance and tumor penetration. Methods The human MA39 scFv, selected for its ability to recognize a CEA epitope expressed on human colon carcinomas, was first isolated from a large semi-synthetic ETH-2 antibody phage library, panned on human purified CEA protein. Subsequently, by in vitro mutagenesis of a gene encoding for the scFv MA39, a new library was established, and new scFv antibodies with improved affinity towards the CEA cognate epitope were selected and characterized. Results The scFv MA39 antibody was affinity-maturated by in vitro mutagenesis and the new scFv clone, E8, was isolated, typed for CEA family member recognition and its CEACAM1, 3 and 5 shared epitope characterized for expression in a large panel of human normal and tumor tissues and cells. Conclusion The binding affinity of the scFv E8 is in a range for efficient, in vivo, antigen capture in tumor cells expressing a shared epitope of the CEACAM1, 3 and 5 proteins. This new immunoreagent meets all criteria for a potential anticancer compound: it is human, hence poorly or not at all immunogenic, and it binds selectively and with good affinity to the CEA epitope expressed by metastatic melanoma and colon and lung carcinomas. Furthermore, its small molecular size should provide for efficient tissue penetration, yet give rapid plasma clearance.

Pavoni, Emiliano; Flego, Michela; Dupuis, Maria Luisa; Barca, Stefano; Petronzelli, Fiorella; Anastasi, Anna Maria; D'Alessio, Valeria; Pelliccia, Angela; Vaccaro, Paola; Monteriu, Giorgia; Ascione, Alessandro; De Santis, Rita; Felici, Franco; Cianfriglia, Maurizio; Minenkova, Olga

2006-01-01

69

Conflits, inefficience du capitalisme et politique économique  

Microsoft Academic Search

[fre] Conflits, inefficience du capitalisme et politique économique. . Cet article analyse, dans une perspective dynamique, les conséquences sur la croissance du conflit pour le partage du revenu. Après avoir étudié la robustesse de la propriété d\\

Pierre Cahuc; Anne Bauer

1989-01-01

70

Kyste hydatique primitif du sein  

PubMed Central

Le kyste hydatique du sein est une parasitose rare même dans les pays endémiques. Nous rapportons une nouvelle observation d'une patiente de 30 ans qui présentait une masse du sein gauche. Le diagnostic de kyste hydatique du sein a été évoqué devant les données de l'examen clinique et de la mammographie couplée à l’échographie. Le geste chirurgical a consisté en une kystectomie. L'examen anatomopathologique de la pièce opératoire a confirmé le diagnostic.

Mouslik, Rabii; Settaf, Abdellatif; Elalami, Yacir; Lahnini, Hicham; Lahlou, Khalid; Chad, Bouziane

2012-01-01

71

Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19  

Microsoft Academic Search

The carcinoembryonic antigen (CEA)-like genes are members of a large gene family which Is part of the immunoglobulln superfamily. The CEA family is divided into two major subgroups, the CEA-subgroup and the pregnancy-specific glycoprotein (PSG)-subgroup. In the course of an effort to develop a set of overlapping cosmlds spanning human chromosome 19, we identified 245 cosmids In a human chromosome

Katherine Tynan; Anne Olsen; Barbara Trask; Pieter de Jong; John Thompson; Wolfgang Zimmermann; Anthony Carrano; Harvey Mohrenweiser

1992-01-01

72

BR-MA, OM-MA, GI-MA and CEA: Clinical Evaluation Using the IMMULITE Analyzer  

Microsoft Academic Search

This study was designed to clinically evaluate four tumour markers on the automated chemiluminescent immunoanalyser, IMMULITE, and to compare the data obtained with those of established immunoassays. IMMULITE BR-MA and CEA were compared to the CIS ELSA CA 15-3 and either the CIS CEA-ENZELSA or TOSOH (AIA 1200) CEA in 206 serum samples from 32 breast cancer patients. A parallel

A. van Dalen

1999-01-01

73

Prognostic Significance of CEA, CA 19-9 and CA 72-4 Preoperative Serum Levels in Gastric Carcinoma  

Microsoft Academic Search

The prognostic value of preoperative serum levels of CEA, CA 19-9 and CA 72-4 tumor markers was investigated in 153 patients resected for gastric cancer. The positivity rates for CEA, CA 19-9 and CA 72-4 were 20.9, 34.6 and 28.1%, respectively. Multiple logistic regression analysis for positive levels of tumor markers indicates that CEA positivity is significantly related to the

Daniele Marrelli; Franco Roviello; Alfonso De Stefano; Maurizio Farnetani; Lorenzo Garosi; Angelo Messano; Enrico Pinto

1999-01-01

74

Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers  

PubMed Central

Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.). Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc.), prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each) and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years) and 8–65 years of smoking (mean = 37.7 ± 16.8). 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ? 20 minutes); Medium (1–3; 1–3; >20 min to ? 2 hrs) and Heavy smokers (2–4; 3–8; >2 hrs to ? 6 hrs). Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59) were not significantly different (p ? 0.0937) from the levels in non-smokers (2.35 ± 0.71 ng/ml). Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5); 2.52 ± 1.15 ng/ml (n = 28) and 5.11 ± 3.08 ng/ml (n = 26) respectively. The levels in medium smokers and non-smokers were also not significantly different (p ? 0.9138). In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ? 0.0001567). Conclusion Overall CEA levels in exclusive hookah smokers were low compared to cigarette smokers. However, heavy hookah smoking substantially raises CEA levels. Low-nitrosamines smokeless tobacco of the SNUS Swedish type could be envisaged as an alternative to smoking for this category of users and also, in a broad harm reduction perspective, to the prevalent low-quality moist snuff called naswar.

Sajid, Khan Mohammad; Chaouachi, Kamal; Mahmood, Rubaida

2008-01-01

75

Les poisons du fuseau  

Microsoft Academic Search

Résumé  Les poisons du fuseau constituent un groupe de médicaments anticancéreux d’origine naturelle caractérisés par leur cible,\\u000a le fuseau achromatique qui permet aux chromosomes de migrer lors de la mitose. Les vinca-alcaloïdes (vinblastine, vincristine,\\u000a vindésine, vinorelbine) inhibent la polymérisation de la tubuline en microtubules et les taxanes (paclitaxel et docétaxel)\\u000a inhibent la dépolymérisation des microtubules. La résistance à ces agents peut

J. Robert

2007-01-01

76

The role of CA-242 and CEA in surveillance following curative resection for colorectal cancer.  

PubMed Central

This study was undertaken to evaluate the role of a new tumour marker, CA-242, alone or in combination with CEA in the practical management of colorectal cancer patients after potentially curative resection. A cohort of 149 patients who had undergone 'curative' surgery was followed up according to an intensive protocol in order to detect recurrent disease. Over a median tumour marker follow-up period of 24 months there were 25 recurrences in 24 patients. Both CEA and CA-242 alone detected half the local recurrences. The sensitivity of CEA was 84% for distant or mixed recurrence compared with 64% for CA-242. An abnormality of either CEA or CA-242 enabled detection of five out of six local recurrences and 17 out of 19 distant or mixed recurrences with a median lead time of 5 months for each marker. Both markers were elevated concurrently in only one local and 11 distant recurrences. While CA-242 alone is not superior to CEA, their combined use (either abnormal) has a high sensitivity (88%), specificity (78%) and negative predictive value (97%); this may be useful in reducing unnecessary investigations in follow-up programmes and as a guide to the initiation of further treatment for recurrent disease.

Hall, N. R.; Finan, P. J.; Stephenson, B. M.; Purves, D. A.; Cooper, E. H.

1994-01-01

77

Identification, genotyping, and molecular evolution analysis of duck circovirus.  

PubMed

Duck circovirus (DuCV) is a contagious immunosuppressive virus affecting many duck species, which is responsible for multiple outbreaks in poultry industries worldwide. In this study, the first DuCV isolate GH01 was identified in Sichuan by PCR, which shared a high level of nucleotide identity (81.8-99.4%) with sequences of other DuCV isolates available in GenBank. Comparative phylogenetic and pairwise sequence comparison analyses indicated that DuCV could be divided into two genotypes (DuCV-1 and DuCV-2) and six subtypes (1a, 1b, 1c, 2a, 2b and 2c) based on the complete genome sequence. The results revealed that both DuCV-1 and DuCV-2 had evolved from the same ancestor but undergone divergent evolution. Interestingly, phylogenetic analyses indicated that three isolates were classified into a cluster DuCV-2a using complete DuCV genome sequence and cap gene, except rep gene. Recombination analyses revealed that DuCV-2a arose from recombination between DuCV-1a and DuCV-2b isolates within the rep genes, and the recombination events mainly occur both in non-structural protein coding region and structural protein coding region. In addition, the mechanisms of recombination supporting the genetic variability in DuCV isolates were investigated. Likewise, selective pressure indicated that purifying selection had been a major driving force in maintaining diversity among the DuCV isolates. Because eradicating the virus from commercial ducks is impossible, it is necessary to take effective control measures and implement them throughout the world. PMID:23932991

Zhang, Zhilong; Jia, Renyong; Lu, Yanyan; Wang, Mingshu; Zhu, Dekang; Chen, Shun; Yin, Zhongqiong; Chen, Xiaoyue; Cheng, Anchun

2013-08-06

78

Serum sialic acid (TSA/LSA) and carcinoembryonic antigen (CEA) levels in cancer patients undergoing radiotherapy.  

PubMed

The main aim of this study was to evaluate the response of total Sialic Acid (TSA) and "Lipid-bound" Sialic Acid (LSA) compared to Carcinoembryonic Antigen (CEA), in 284 patients undergoing radiotherapy. Serial measurements of TSA by the enzymatic method (Boehringer-Mannheim Kit), LSA by the resorcinol-HC1 (Katopodis and Stock) and CEA by EIA (Abbott Kit) were performed in a total of 1017 blood sera. We statistically estimated the four greater groups of cancer patients [bladder (69), lung (58), uterus (31) and breast (29)]. Diagnostic marker sensitivities (% true positives) estimated from the 0-time-values--before initiation of radiotherapy--in relation to the established cut-off levels were in decreasing order: TSA 89.3% (80 mg/dL). LSA 88.8% (20 mg/dL) and CEA 26.75% (5 ng/mL). The overall tumor marker response to treatment, after its completion, estimated as % of patients with final blood serum levels of these markers, was in decreasing order: LSA 85.6%, TSA 81.3%, and CEA 65.8%. These data show that a) the diagnostic sensitivity of Sialic Acid (LSA/TSA) is more than 3 times higher than that of CEA and b) the response of Sialic Acid (LSA/TSA) to treatment is about 15% higher than that of CEA. In conclusion, this study confirms the high diagnostic sensitivity of Sialic Acid as a tumor marker and suggests that, with marginal superiority of Sialic Acid, all three markers are sufficiently responsive to be employed as adjunctive means in monitoring cancer patients underdoing radiotherapy. PMID:1567173

Stringou, E; Chondros, K; Kouvaris, J; Kakari, S; Papavassiliou, K

79

Latest pixel size reduction of uncooled IR-FPA at CEA, LETI  

NASA Astrophysics Data System (ADS)

Recent developments at the Infrared Lab (LIR) of CEA, LETI have been concentrated on the pixel size reduction of uncooled infrared detectors. With the support from French company ULIS, we have successfully demonstrated the technological integration of 12?m pixels on a commercial TV-format read-out circuit (VGA-ROIC) supplied by ULIS. The 12?m pixel has been designed, processed and characterized in CEA, LETI and first results showed exceptional performances. This paper presents the characterization and associated imagery results.

Becker, Sebastien; Imperinetti, Pierre; Yon, Jean-Jacques; Ouvrier-Buffet, Jean-Louis; Goudon, Valérie; Hamelin, Antoine; Vialle, Claire; Arnaud, Agnès.

2012-10-01

80

Elevated levels of CA 19-9 and CEA in pancreatic cancer-associated diabetes  

Microsoft Academic Search

Background  The relationship between diabetes and pancreatic cancer has been established by more than several decades of research. However,\\u000a serum levels of CEA and CA 19-9 in diabetic pancreatic cancer has not been shown.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  Preoperative serum levels of CEA and CA 19-9 and clinicopathological characteristics were retrospectively analyzed in 79 with\\u000a or 229 without diabetes in pancreatic ductal adenocarcinoma (PDA) patients.

Qingqu Guo; Muxing Kang; Bo Zhang; Ying Chen; Xin Dong; Yulian Wu

2010-01-01

81

The predictive of tumour markers CA 15-3, TPS and CEA in breast cancer recurrence.  

PubMed

The predictive values of tumour markers Carcinoma-Associated Antigen CA 15-3, Tissue Polypeptide Specific Antigen (TPS) and Carcinoembryonic Antigen (CEA) in recurrence of breast cancer are unclear. The aim of this study was to examine the predictive value of these markers in our population of 1448 patients with diagnosed breast cancer. Data and mean follow-up of 4.4 years were available on 1082 women of whom 277 had documented recurrence (mean follow up 5.7 years). The recurrence free patients had a mean follow up of 3.9 years. The sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of CA 15-3, TPS and CEA for visceral, bony and locoregional recurrence were calculated. CA 15-3 was the most sensitive marker, 68% for visceral and 69% for bony recurrence. This compared with TPS, 64% and 51% and CEA, 27% and 46% for visceral and bony recurrence respectively. The positive predictive value of CA 15-3 at 47% for visceral and 54% for bony recurrence was greater than that for TPS (visceral 25%, bony 21%) or CEA (visceral 18%, bony 26%). The sensitivity of CA 15-3 and TPS for locoregional recurrence was low at 23% and 17% respectively. A combination of CA 15-3, TPS and CEA failed to increase the sensitivity of CA 15-3 for visceral recurrence. However, a marginally increased sensitivity was recorded for combined CA 15-3 and TPS (70%) and for combined CA 15-3, TPS and CEA (71%) in bony recurrence. The mean lead time effect in visceral recurrence for TPS and CA 15-3 were 8 and 10 months respectively. In patients with bony recurrence the mean lead time effect for TPS and CA 15-3 were 7.5 and 8.25 months. Mean lead time effect was increased to 9 and 11 months for bony and visceral recurrence respectively when CA 15-3 and TPS were combined. CA 15-3 remains the most sensitive tumour marker in breast cancer follow up with a significantly greater positive predictive value when compared to TPS or CEA. Both TPS and CEA failed to complement the sensitivity of CA 15-3 when measured in combination. PMID:14732178

Given, M; Scott, M; Mc Grath, J P; Given, H F

2000-10-01

82

DC-SIGN and SRCL bind glycans of carcinoembryonic antigen (CEA) and CEA-related cell adhesion molecule 1 (CEACAM1): recombinant human glycan-binding receptors as analytical tools  

Microsoft Academic Search

Members of the family of carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) belonging to the immunoglobulin (Ig) superfamily are expressed in a variety of normal and malignant human tissues. As components of the cell membrane, these glycoproteins can make contact with adjacent cells. CEACAM1 and CEACAM5 (CEA) express Lewisx (Lex) structures. As shown by mass spectrometry in conjunction with enzymatic

Alexandra Samsen; Valentina Bogoevska; Birgit Klampe; Ana-Maria Bamberger; Lothar Lucka; Andrea K. Horst; Peter Nollau; Christoph Wagener

2010-01-01

83

Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19.  

PubMed Central

The carcinoembryonic antigen (CEA)-like genes are members of a large gene family which is part of the immunoglobulin superfamily. The CEA family is divided into two major subgroups, the CEA-subgroup and the pregnancy-specific glycoprotein (PSG)-subgroup. In the course of an effort to develop a set of overlapping cosmids spanning human chromosome 19, we identified 245 cosmids in a human chromosome 19 cosmid library (6-7X redundant) by hybridization with an IgC-like domain fragment of the CEA gene. A fluorescence-based restriction enzyme digest fingerprinting strategy was used to assemble 212 probe-positive cosmids, along with 115 additional cosmids from a collection of approximately 8,000 randomly selected cosmids, into five contigs. Two of the contigs contain CEA-subgroup genes while the remaining three contigs contain PSG-subgroup genes. These five contigs range in size from 100 kb to over 300 kb and span an estimated 1 Mb. The CEA-like gene family was determined by fluorescence in situ hybridization to map in the q13.1-q13.2 region of human chromosome 19. Analysis of the two CEA-subgroup contigs provided verification of the contig assembly strategy and insight into the organization of 9 CEA-subgroup genes.

Tynan, K; Olsen, A; Trask, B; de Jong, P; Thompson, J; Zimmermann, W; Carrano, A; Mohrenweiser, H

1992-01-01

84

The diagnostic value of plasma carcinoembryonic antigen (CEA) in pancreatic disease. Medical Research Council Tumour Products Committee: Clinical Subgroup.  

PubMed Central

Whilst the plasma CEA levels in pancreatic carcinoma tend to be higher than in pancreatitis, knowledge of the plasma CEA level is of little additional value in the differential diagnosis of malignant and non-malignant pancreatic disease, and contributes little to the clinical management of such disorders.

1980-01-01

85

Decommissioning of the nuclear licensed facilities at the Fontenay aux Roses CEA center  

Microsoft Academic Search

Available in abstract form only. Full text of publication follows: The French Atomic Energy Commission (CEA) center at Fontenay aux Roses (CEN-FAR) is the Commission's oldest center is located in the southern suburbs of Paris. It was opened on 26 March 1946 to host the first French nuclear reactor ZOE that went critical on 12 December 1946. The first laboratories

Michel Jeanjacques; Laurence Piketty; Nathalie Letuhaire; Lionel Mandard; Igor Meden; David Estivie; Jean Francois Boissonneau; Alain Fouquereau; Eric Pichereau; Cedric Binet

2007-01-01

86

Environmental Profiles of Paper vs. Electronic UC-CEAS Annual Reports  

EPA Science Inventory

In 2010, the University of Cincinnati College of Engineering and Applied Sciences (UC-CEAS) created a new electronic format for the Annual Report that could be distributed through the collegeâ??s website to replace the prior print version. In order to determine the environmental co...

87

BAGHEERA: A new experimental facility at CEA \\/ Valduc for actinides studies under high dynamic loading  

Microsoft Academic Search

This paper is a technical presentation about a new experimental facility recently developed at CEA\\/Valduc, BAGHEERA, a French acronym for ``Hopkinson And High Speed Experiments Glove Box''. This facility is used since mid-2003 to characterize the physical and mechanical behaviour of actinides under high dynamic loadings. For this purpose, four basic experimental devices are confined inside a single glove box:

G. Roy; F. Llorca; G. Lanier; S. Lamalle; J. Beaulieu; P. Antoine; P. Martinuzzi

2006-01-01

88

PZ Fiber Loss Measurements at LLNL and Plan to Confirm Results at CEA/Thomson  

SciTech Connect

The objective of this paper is to confirm the slow-axis loss of less than 0.1 dB/m for the PZ fiber manufactured for LLNL by 3M and to provide samples of the fiber to CEA/Thomson that will permit them to readily verify this result.

Bass, I.L.

2000-04-17

89

Latest achievements of CEA and AREVA NP on HTR fuel fabrication  

Microsoft Academic Search

Extensive research and development programs on the (Very) High Temperature gas cooled Reactor (V\\/HTR) are being conducted by many countries mainly promoted by the attractiveness of this concept and its capability for other applications than electricity production, such as high temperature process heat and cogeneration. In this international context, the Commissariat à l’Energie Atomique (CEA) and AREVA NP through its

François Charollais; Christophe Perrais; Dominique Moulinier; Marc Perez; Marie-Pierre Vitali

2008-01-01

90

The CEA Test in Urologic Cancer: an Evaluation and a Review  

Microsoft Academic Search

The diagnostic value of the carcinoembryonic antigen test was evaluated in 2,029 blood and urine samples from 308 urologic cancer patients, 13 patients with nonuro-logic cancer, 20 urologic patients with nonmalignant disease, and in 30 controls. The blood CEA test was positive in 50 % of patients with active urologic malignancy and in 35 % of patients with inactive malignancy.

Patrick Guinan; Alvin Dubin; Irving Bush; Hassan Alsheik; Richard J. Ablin

1975-01-01

91

Aeroacoustics research in Europe: The CEAS-ASC report on 2010 highlights  

Microsoft Academic Search

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, ``aeroacoustics'' encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe.This paper is a

Attila Balázs Nagy

2011-01-01

92

Biofunctionalized gold nanoparticles for SPR-biosensor-based detection of CEA in blood plasma.  

PubMed

We report on the use of new biofunctionalized gold nanoparticles (bio-AuNPs) that enable a surface plasmon resonance (SPR) biosensor to detect low levels of carcinoembryonic antigen (CEA) in human blood plasma. Bio-AuNPs consist of gold nanoparticles functionalized both with (1) streptavidin, to provide high affinity for the biotinylated secondary antibody used in the second step of the CEA sandwich assay, and with (2) bovine serum albumin, to minimize the nonspecific interaction of the bio-AuNPs with complex samples (blood plasma). We demonstrate that this approach makes it possible for the SPR biosensor to detect CEA in blood plasma at concentrations as low as 0.1 ng/mL, well below normal physiological levels (approximately nanograms per milliliter). Moreover, the limit of detection achieved using this approach is better by a factor of more than 1,000 than limits of detection reported so far for CEA in blood plasma using SPR biosensors. PMID:22895740

Špringer, Tomáš; Homola, Ji?í

2012-08-16

93

Elevated preoperative CEA is associated with worse survival in stage I-III rectal cancer patients  

PubMed Central

Background: The objective of this investigation was to assess whether preoperative carcinoembryonic antigen (CEA) level is an independent predictor of overall survival in rectal cancer patients. Methods: All patients (n=504) undergoing a resection for stage I–III rectal cancer at the Kantonsspital St Gallen were included into a database between 1991 and 2008. The impact of preoperative CEA level on overall survival was assessed using risk-adjusted Cox proportional hazard regression models and propensity score methods. Results: In risk-adjusted Cox proportional hazard regression analyses, preoperative CEA level (hazard ratio (HR): 1.98, 95% confidence interval (CI): 1.36–2.90, P<0.001), distance from anal verge (<5?cm: HR: 1.93, 95% CI: 1.11–3.37; P=0.039), older age (HR: 1.07, 95% CI: 1.05–1.09; P<0.001), lower body mass index (HR: 0.94, 95% CI: 0.89–0.98; P=0.006), advanced tumour stage (stage II HR: 1.41, 95% CI: 0.85–2.32; stage III HR: 2.08, 95% CI: 1.31–3.31; P=0.004), R 1 resection (HR: 5.65, 95% CI: 1.59–20.1; P=0.005) and chronic kidney disease (HR: 2.28, 95% CI: 1.03–5.04; P=0.049) were all predictors for poor overall survival. Conclusion: This is one of the first investigations based on a large cohort of exclusively rectal cancer patients demonstrating that preoperative CEA level is a strong predictor of decreased overall survival. Preoperative CEA should be used as a prognostic factor in the preoperative assessment of rectal cancer patients.

Tarantino, I; Warschkow, R; Worni, M; Merati-Kashani, K; Koberle, D; Schmied, B M; Muller, S A; Steffen, T; Cerny, T; Guller, U

2012-01-01

94

Une méthodologie d'évaluation comptable du coût du capital des entreprises françaises (1984-2002)  

Microsoft Academic Search

[fre] La méthode d’évaluation du coût d’usage du capital sur données comptables individuelles d’entreprises françaises présentée ici repose sur une modélisation tenant compte de la structure du financement, du taux d’intérêt bancaire et de la fiscalité pesant sur les entreprises et sur les actionnaires. L’analyse de l’évolution du coût du capital ainsi construit montre tout d’abord l’hétérogénéité des taux d’intérêts

Xavier Boutin; Simon Quantin

2008-01-01

95

Improving tumor targeting and therapeutic potential of Salmonella VNP20009 by displaying cell surface CEA-specific antibodies  

PubMed Central

Genetically modified Salmonella typhimurium VNP20009 (VNP) is a useful vehicle for cancer therapy and vaccine development but exhibits limited tumor targeting in vivo. We engineered a novel VNP derivative that expressed carcinoembryonic antigen (CEA)-specific single chain antibody fragments (scFv) on the cell surface to increase tumor-specific targeting. There was significant scFv cell surface display visualized by flow cytometry and confocal microscopy when cells were probed with fluorescently labeled CEA. Atomic force microscopy (AFM) measurements on whole bacteria confirmed binding of unlabelled CEA to the displayed scFv. The modified VNP strain exhibited increased localization in the upper gastrointestinal tract of CEA transgenic mice and accumulated in CEA-expressing tumors. Furthermore, treatment with a single dose of the VNP derivative inhibited growth of MC38CEA tumors and was associated with local accumulation of CD3+ T cells and CD11b+ macrophages. The display of antibody fragments on the surface of VNP represents a novel strategy for both targeting CEA-expressing tumors and increasing the immunogenicity of Salmonella-based vaccines for cancer.

Bereta, Michal; Hayhurst, Andrew; Gajda, Mariusz; Chorobik, Paulina; Targosz, Marta; Marcinkiewicz, Janusz; Kaufman, Howard L.

2009-01-01

96

Lymphome folliculaire primitif du duodénum  

Microsoft Academic Search

\\u000a Résumé  La localisation duodénale des lymphomes folliculaires est considérée comme rare, mais l’incidence de ces tumeurs est en augmentation.\\u000a Nous rapportons une observation de lymphome primitif du duodénum, montrant la similitude des données endoscopiques avec celles\\u000a de la papulose lymphomateuse des lymphomes du manteau. Les techniques immunohistochimiques et cytogénétiques aident à différencier\\u000a ces deux tumeurs. Il est essentiel de les différencier

D. Béchade; J. Desramé; R. Soulard; Ph. Camparo; Th. de Revel; Ph. Gaulard; J. J. Raynaud; J. P. Algayres

2005-01-01

97

L'Aventure du LHC  

ScienceCinema

Cette présentation s’adressera principalement aux personnes qui ont construit le LHC. La construction du LHC fut longue et difficile. De nombreux problèmes sont apparus en cours de route. Tous ont été résolus grâce au dévouement et à l’engagement du personnel et des collaborateurs. Je reviendrai sur les coups durs et les réussites qui ont marqués ces 15 dernières années et je vous montrerai combien cette machine, le fruit de vos efforts, est extraordinaire.

98

Serum NSE, CEA, CT, CA 15-3 levels in human lung cancer.  

PubMed

The significance of neuron specific enolase (NSE) was investigated in comparison with other tumor markers (CEA, CT, CA 15-3) used in the diagnosis and treatment monitoring of lung cancer. As previously described, the calcitonin assay proved to have very low sensitivity for small cell lung cancer (SCLC). The serum NSE assay was, however, shown to be a useful diagnostic aid for discrimination between histologically different lung cancers, and therefore this assay may be a valuable tool for treatment monitoring in SCLC patients. CA 15-3, also an unspecific marker, showed similar sensitivity to the NSE assay in SCLC patients, the sensitivity being higher than CEA in non small cell lung cancer (NSCLC). PMID:1965544

Nutini, S; Cappelli, G; Benucci, A; Catalani, C; Nozzoli, F

99

C.-E.A. Winslow Day: Proceedings of the June 3, 1977 Centenary Celebration  

PubMed Central

Sponsored by Yale University, the City of New Haven, and the John B. Pierce Foundation, the C.-E.A. Winslow Day program consisted of speeches by Mr. Leonard Woodcock, President Emeritus, U.A.W., the Honorable Kenneth Gibson, Mayor of Newark, and Dr. Hector Acuña, Director, Pan American Health Organization; reminiscences of Ira Hiscock, Anna M.R. Lauder Professor Emeritus of Public Health, Mary Elizabeth Tennant, Associate Professor Emeritus of Nursing (Public Health), A. Pharo Gagge, Emeritus Fellow, John B. Pierce Foundation, and Mrs. Harriet Welch, Former President of the VNA of New Haven. The proceedings also included the presentation of gifts and the official C.-E.A. Winslow Day Proclamation.

Viseltear, Arthur J.

1977-01-01

100

Optical feedback cavity-enhanced absorption spectroscopy (OF-CEAS) in a ring cavity  

NASA Astrophysics Data System (ADS)

Optical feedback cavity-enhanced absorption spectroscopy (OF-CEAS) has been demonstrated by coupling a distributed feedback diode laser to a ring cavity. Frequency-selected light decaying from the ring cavity is retro-reflected, inducing a counter-propagating intra-cavity beam, and providing optical feedback to the laser. At specific laser-to-cavity distances, all cavity mode frequencies return to the diode laser with the same phase, allowing spectra to be accumulated across the range of frequencies of the current-tuned laser. OF-CEAS has been used to measure very weak oxygen isotopologue (16O18O and 16O17O) absorptions in ambient air at wavelengths near 762 nm using the electric-dipole forbidden O2 A-band. A bandwidth reduced minimum detectable absorption coefficient of 2.2×10-9 cm-1 Hz-1/2 is demonstrated.

Hamilton, D. J.; Nix, M. G. D.; Baran, S. G.; Hancock, G.; Orr-Ewing, A. J.

2010-08-01

101

High Level Gamma and Neutron Irradiation of Silica Optical Fibers in CEA OSIRIS Nuclear Reactor  

Microsoft Academic Search

In the final objective of elaborating an optical sensor of dimensional change in a nuclear testing reactor, we present extreme high level irradiation tests, up to 1.3 1020 nfast\\/cm2 and 16 GGy, conducted on high purity silica and hollow core photonic bandgap (PBG) fibers. These tests are performed in the OSIRIS reactor at CEA Saclay. We measure continuously radiation induced

Guy Cheymol; Hervé Long; Jean FranÇois Villard; Benoît Brichard

2008-01-01

102

Low temperature thermal—and magnetic properties of CeP and CeAs  

Microsoft Academic Search

CeP and CeAs are characterized by low temperature measurements of the specific heat, the thermal expansion, the electrical resistivity and the magnetization of single crystal specimens. These physical properties are found to be very sensitive to crystal perfection and chemical composition in both the paramagnetic and the magnetically ordered state. In the intrinsically antiferromagnetic CeP, imperfections can give rise to

F. Hulliger; H. R. Ott

1978-01-01

103

Muon Knight shift and ? + site in the monopnictide CeAs  

Microsoft Academic Search

The transverse field ?SR-signal from ?+ implanted in a CeAs single crystal shows a splitting into two components, displaying a positive and a negative Knight shift,\\u000a respectively which both scale reasonably well with the magnetic bulk susceptibility above 10 K. The orientation dependence\\u000a of the frequency shifts, measured at 15 K, is fully accounted for by the demagnetization field, implying

A. Schenck; A. Amato; F. N. Gygax; M. Pinkpank; H. R. Ott

1997-01-01

104

Superiority of CA 125 over CA 19-9 and CEA for epithelial ovarian malignancies  

Microsoft Academic Search

In this study tumor markers CA 125, CEA and CA 19-9 were evaluated to assess the best tumor marker for epithelial ovarian\\u000a carcinomas in diagnosis, prognosis and management. The results indicated that CA 125 is the best and the most superior marker\\u000a today for the epithelial ovarian malignancies irrespective of the histologic type. CA 125 has the highest positivity rate

A. Saraswathi; T. Malati

1995-01-01

105

[Albumin mRNA and pCEA in the histopathologic diagnosis of hepatocellular carcinoma].  

PubMed

Extrahepatic neoplasms metastatic to the liver histologically are often indistinguishable from hepatocellular carcinoma (HCC). The differential diagnosis between HCC and metastatic liver tumours can be even more difficult in ultrasound guided fine-needle biopsies. Purpose of the present study was to investigate the utility of immunohistochemical staining with polyclonal anticarcinoembryonic antigen (pCEA) antibody and of in situ hybridization (ISH) revealing human albumin mRNA, with emphasis on tissues obtained via fine-needle procedure. Cases consisted of 52 primary HCC; 2 HCC metastatic to vertebral bones; 18 tumours metastatic to the liver; 24 non-hepatocellular tumours metastatic to the skin, lymph nodes and brain; 2 immature teratomas with areas of hepatoid differentiation. Forty-seven HCC (90%) and 7 liver metastases (38%) were obtained by ultrasound guided fine-needle biopsies (21 g needle was used). All the remaining cases were surgical specimens. All the cases were studied with immunohistochemistry for pCEA and ISH using a cRNA probe for human albumin mRNA. The immunohistochemical staining using pCEA showed a canalicular type of positivity in 37 cases of HCC (71%), in one HCC metastatic to vertebral bone and in the hepatoid areas of one immature teratoma. No canalicular type of positivity was obtained in non-hepatocellular neoplasms metastatic to the skin, brain, lymph-nodes and liver. Albumin mRNA was detected in 51 (98%) primary HCC, in both HCC bone metastases, and in the hepatoid areas of both immature teratomas. No positivity was obtained in non-hepatocellular tumours. The data here obtained indicate that immunostaining with pCEA and ISH revealing human albumin mRNA are markers of hepatocellular differentiation and confirm their diagnostic utility. Detection of albumin mRNA showed a higher sensitivity. In addition the cRNA probe here used seems more sensitive that the oligonucleotide probes employed in previous studies. PMID:10630075

Foschini, M P; Macchia, S; Baccarini, P; Milandri, G L; Losi, L; Spongano, P; Panarelli, M; Dal Monte, P R; Eusebi, V

1999-08-01

106

Aeroacoustics research in Europe: The CEAS-ASC report on 2011 highlights  

NASA Astrophysics Data System (ADS)

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe.This paper is a report on highlights of aeroacoustics research in Europe in 2011, compiled from information provided to the ASC of the CEAS.During 2011, a number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarized in this paper, as well as highlights from other programmes funded by national programmes or by industry. Furthermore, a concise summary of the CEAS-ASC workshop "Acoustic Liners and Associated Propagation Techniques" held in Lausanne in October 2011 is included in this report.Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

McAlpine, A.; Astley, R. J.

2012-10-01

107

Enhanced CEA production associated with aspirin in a culture of CW2 cells on some polymeric films  

Microsoft Academic Search

Human colorectal adenocarcinoma tumor (CW2) cells were cultivated in RPMI 1640 media containing 0–7.5 mM aspirin and 10% fetal\\u000a bovine serum for the production of carcinoembryonic antigen (CEA). By adding aspirin to the media, the production of CEA per\\u000a cell increased by up to one hundred fold compared to cultivation in normal media containing no aspirin, even though the total

Akon Higuchi; Shigeru Uchiyama; Makoto Demura; Tetsuo Asakura; Chong-Su Cho; Toshihiro Akaike; Hirokazu Takarada; Mariko Hara

1999-01-01

108

CEA development of filled bolometer arrays at submillimeter wavelengths A possible application to ground-based telescopes at Dome C  

Microsoft Academic Search

Accompanying the development of the PACS photometer camera (60 210 mum) on the Herschel Space Observatory, CEA\\/SAp and CEA\\/LETI have developed a new type of filled bolometer arrays. We present a camera using these ``CCD-like'' detectors for ground-based submillimeter applications. Such an instrument could potentially be operated in all atmospheric windows between 200 and 870 mum on a submillimetre-wave single-dish

V. Minier; V. Revéret; L. Rodriguez; J. Le Pennec; P. André; B. Horeau; P. Agnèse

2005-01-01

109

Localization of CEA, HCG, Lysozyme, alpha-1-antitrypsin, and alpha-1-antichymotrypsin in gastric cancer and prognosis  

Microsoft Academic Search

Carcinoembryonic antigen (CEA),ß-human chorionic gonadotropin (HCG), alpha-1-antichymotrypsin (ACT), alpha-1-antitrypsin (AAT) and Lysozyme (LYS) were traced by immunoperoxidase staining in gastric carcinomas. The immunohistological results were evaluated in relation to histological types (WHO and Laurén), stage of disease, grade and survival time. CEA was demonstrated in 96% of the tumours, HCG in 34%, ACT in 78%, AAT in 42%, and LYS

Ch. Wittekind; R. Wachner; W. Henke; S. Kleist

1986-01-01

110

Diagnostic and prognostic values of CA 19-9 and CEA in periampullary cancers 1 1 No competing interests declared  

Microsoft Academic Search

Background: The roles of carcinoembryonic antigen (CEA) and carbohydrate antigen 19-9 (CA 19-9) in periampullary cancers have not been clearly established. Diagnostic and prognostic values of these two tumor markers were clarified in this study.Study Design: Preoperative serum levels of CEA and CA 19-9, and clinicopathologic features were retrospectively reviewed in 143 surgical patients with periampullary cancer from 1989 to

Shi-Yi Kau; Yi-Ming Shyr; Cheng-Hsi Su; Chew-Wun Wu; Wing-Yiu Lui

1999-01-01

111

The role of CEA, TPA and CA 19-9 in the early detection of recurrent colorectal cancer  

Microsoft Academic Search

Eighty-eight consecutive patients who underwent curative resection for colorectal cancer between 1983 and 1985 were studied prospectively to evaluate the roles of sequential CEA, TPA and CA 19-9 determinations and independent clinical examination in the early diagnosis of resectable recurrences. Twenty nine recurrences were detected between 8 and 38 months after primary surgery. CEA, TPA and CA 19-9 showed a

P. Barillari; G. Ramacciato; R. de Angelis; P. Gozzo; P. Aurello; M. Indinnimeo; S. Valabrega; F. D'Angelo; G. Fegiz

1989-01-01

112

Role of CEA, TPA, and Ca 19-9 in the early detection of localized and diffuse recurrent rectal cancer  

Microsoft Academic Search

Sixty-six consecutive patients who underwent curative resection for rectal cancer were studied prospectively to evaluate the roles of sequential carcinoembryonic antigen (CEA), tissue plasminogen activator (TPA), and carcinomatous antigen 19-9 (Ca 19-9) determinations in the early diagnosis of resectable recurrences. Thirty-three recurrences were detected between 6 and 42 months. CEA, TPA, and Ca 19-9 showed a sensitivity of 72.7 percent,

P. Barillari; A. Bolognese; P. Chirletti; M. Cardi; P. Sammartino; V. Stipa

1992-01-01

113

The prognostic significance of gastric juice CA 19-9 and CEA levels in gastric carcinoma patients  

Microsoft Academic Search

Aim: The usefulness of gastric juice CA 19-9 and carcinoembryonic antigen (CEA) levels in the diagnosis of gastric carcinoma is controversial. There is only one study related with their prognostic value. In this study the clinical significance of gastric juice CA 19-9 and CEA levels in patients with gastric carcinoma was investigated.Methods: Preoperative serum and gastric juice CA 19-9 and

N. Duraker; A. Naci Çelik; N. Gençler

2002-01-01

114

Glycoprotein tumour markers in head and neck neoplasms —a consecutive study on CA50, CA 19-9, and CEA  

Microsoft Academic Search

Summary Serum levels of three glycoprotein tumour antigens (carcino-embryonic antigen, CEA; cancer-associated antigen 50, CA-50; gastrointestinal cancer-associated antigen, CA 19-9) were determined on 125 consecutive patients with tumours of the head and neck region. Elevated CEA values (> 5 units\\/ml) were found in 13\\/70 squamous cell carcinomas, 3\\/21 benign and 4\\/18 malignant salivary gland neoplasms. Elevated CA-50 values (> 17

Hans Gustafsson; Lars Franzén; Kjell Grankvist; Matti Anniko; Roger Henriksson

1988-01-01

115

Del Pezzo surfaces with Du Val singularities  

NASA Astrophysics Data System (ADS)

In this paper we study the problem of existence of orbifold Kaehler-Einstein metrics on del Pezzo surfaces of degree 1 with Du Val singular points. Moreover we compute global log canonical thresholds of del Pezzo surfaces of degree 1 with Du Val singularities and of del Pezzo surfaces of Picard rank 1 with Du Val singularities.

Kosta, Dimitra

2009-04-01

116

Applications attract DuPont  

SciTech Connect

Scientists at DuPont say they have demonstrated the first chemical processing application for high-temperature superconducting (HTS) magnets. DuPont says the work, which uses a HTS magnet to separate mineral contaminants from kaolin, points to the feasibility of a range of HTS applications in industrial processing, including those involving polymerization. DuPont`s success comes after 10 years of work to commercialize high-temperature superconductors. And while superconductors have lost much of their luster since the late 1980s, the company says it is still bullish on their prospects. {open_quotes}At the moment, there`s no real market for superconductors,{close_quotes} says Alan Lauder, general manager/superconductivity. But, he says, several potentially lucrative applications could be commercialized within the next several years.

Rotman, D.

1996-08-07

117

Cri du Chat syndrome.  

PubMed

The Cri du Chat syndrome (CdCS) is a genetic disease resulting from a deletion of variable size occurring on the short arm of chromosome 5 (5p-). The incidence ranges from 1:15,000 to 1:50,000 live-born infants. The main clinical features are a high-pitched monochromatic cry, microcephaly, broad nasal bridge, epicanthal folds, micrognathia, abnormal dermatoglyphics, and severe psychomotor and mental retardation. Malformations, although not very frequent, may be present: cardiac, neurological and renal abnormalities, preauricular tags, syndactyly, hypospadias, and cryptorchidism. Molecular cytogenetic analysis has allowed a cytogenetic and phenotypic map of 5p to be defined, even if results from the studies reported up to now are not completely in agreement. Genotype-phenotype correlation studies showed a clinical and cytogenetic variability. The identification of phenotypic subsets associated with a specific size and type of deletion is of diagnostic and prognostic relevance. Specific growth and psychomotor development charts have been established. Two genes, Semaphorin F (SEMAF) and delta-catenin (CTNND2), which have been mapped to the "critical regions", are potentially involved in cerebral development and their deletion may be associated with mental retardation in CdCS patients. Deletion of the telomerase reverse transcriptase (hTERT) gene, localised to 5p15.33, could contribute to the phenotypic changes in CdCS. The critical regions were recently refined by using array comparative genomic hybridisation. The cat-like cry critical region was further narrowed using quantitative polymerase chain reaction (PCR) and three candidate genes were characterised in this region. The diagnosis is based on typical clinical manifestations. Karyotype analysis and, in doubtful cases, FISH analysis will confirm the diagnosis. There is no specific therapy for CdCS but early rehabilitative and educational interventions improve the prognosis and considerable progress has been made in the social adjustment of CdCS patients. PMID:16953888

Cerruti Mainardi, Paola

2006-09-05

118

Species-specific evolution of immune receptor tyrosine based activation motif-containing CEACAM1-related immune receptors in the dog  

Microsoft Academic Search

BACKGROUND: Although the impact of pathogens on the evolution of the mammalian immune system is still under debate, proteins, which both regulate immune responses and serve as cellular receptors for pathogens should be at the forefront of pathogen-driven host evolution. The CEA (carcinoembryonic antigen) gene family codes for such proteins and indeed shows tremendous species-specific variation between human and rodents.

Robert Kammerer; Tanja Popp; Stefan Härtle; Bernhard B Singer; Wolfgang Zimmermann

2007-01-01

119

AIRIX: an induction accelerator facility developed at CEA for flash radiography in detonics  

NASA Astrophysics Data System (ADS)

AIRIX is an induction linear accelerator which will be used for flash radiography in CEA/DAM. Designed to produce an X-ray dose of more than 500 Rads at 1 meter with an X-ray focal spot size diameter of less than 2 mm (LANL-CEA DAM definition), this facility consists in a 4 MeV/3.5 kA pulsed electron injector and 16 MeV induction accelerator powered by 32 high voltage generators. A prototype of this accelerator, called PIVAIR, has been studied and realized in CEA CESTA near Bordeaux. PIVAIR is a validation step for AIRIX at 8 MeV. It includes an injector (4 MeV, 3.5 kA, 60 ns) and 16 inductor cells supplied by 8 high voltage generators (250 kV, 70 ns). Two different technologies of induction cells have been tested (rexolite insulator or ferrite under vacuum). We have chosen ferrite under vacuum cells technology after comparison of results on beam transport and reliability tests. A focusing experiment at 7.2 MeV of the electron beam as been achieved during summer 1997. We have begun to produce X-rays in October 1997. A dose level of 50 Rad at 1 meter has been achieved with an X-ray spot size diameter of 3.5 to 4 mm (LANL-CEA DAM definition). Static flash radiography of very dense object have been achieved from November 97 until February 98. We have been able to test in situ new kinds of very high sensitive X- ray detectors and to check they had reached our very ambitious goals: (1) quantum efficiency at 5 MeV greater than 50% instead of 1% for luminous screens and film; (2) sensitivity less than 10 (mu) Rad (100 time more sensitive than radiographic luminous screens and films); (3) dynamic range greater than 100; (4) resolution less than 2 mm. We will present in this communication brand new kinds of detection systems, called high stopping power detectors, such as: (1) (gamma) camera with segmented thick crystal of BGO and MCP image intensifier; (2) multistep parallel plate avalanche chamber; (3) pixellized CdTe MeV photoconductor matrix. AIRIX accelerator is being built by THOMSON CSF Company in CEA Moronvilliers near Reims. It is housed in a reinforced concrete bunker and has an overall length of 60 meters. The 20 MeV electron beam will be focused on a 1.5 mm thick Tantalum target to produce an X-ray fluence (flux) of more than 500 Rads one meter from the target. The result is a single radiograph of the device explosion under test with the high stopping power detector located in a blast protection set behind the device. In this communication we will present all these techniques which correspond to a significant effort of CEA begun in 1992. AIRIX facility will be available to run detonics experiments before end of 2000.

Cavailler, Claude

1999-06-01

120

Automation of Pic du Midi 2-m Telescope Bernard Lyot  

NASA Astrophysics Data System (ADS)

Since 2007, Pic du Midi 2-m Telescope Bernard Lyot is dedicated to spectropolarimetry with a scientific niche in stella magnetism. In parallel, TBL is progressively evolving from an analogic human-controlled telescope, to a fully automated computer controlled digital telescope. This evolution required TBL team to replace all electronics and motors with digital system (parvex, brushless motors, buscan) components, and to integrate the dataflow system from proposal to archiving into a fully coordinates, remote-access software suite. A trained technician can already control remotely the telescope, instrument and science programs from anywhere. Further robotisation will require a high-level expert system to be defined.

Lavie-Cambot, Jean-Marie; Lacassagne, F.; Ambert, P.; Arrotis, J.-M.; Argentin, Y.; Arberet, M.-P.; Chereau, E.; Decha, C.; Delaigue, C.; Guesdon, L.; Laurent-Burguiere, D.; Malbreil, G.

2011-03-01

121

The cri du chat syndrome  

Microsoft Academic Search

Data for 331 cri du chat cases, including 34 Danish probands, are reviewed. The incidence and the prevalence among the mentally retarded population amounted to 1\\/45,000 and 1.5\\/1000, respectively. No striking association with prenatal events, parental ages, or birth order could be demonstrated. There was a significant excess of females.

E. Niebuhr

1978-01-01

122

Coherent investigation of nuclear data at CEA DAM: Theoretical models, experiments and evaluated data  

NASA Astrophysics Data System (ADS)

The domain of evaluated nuclear data involves at the same time, a close interaction between the field of nuclear applications and that of nuclear physics, and a close interaction between experiments and theory. The final product, the evaluated data file, synthesises vast amounts of information stemming from all of the above fields. In CEA DAM, all these aspects of nuclear data are investigated in a consistent way, making full use of experimental facilities and high-performance computing as well as numerous national and international collaborations, for the measurement, calculation, evaluation, and validation of nuclear data.

Bauge, E.; Bélier, G.; Cartier, J.; Chatillon, A.; Daugas, J. M.; Delaroche, J. P.; Dossantos-Uzarralde, P.; Duarte, H.; Dubray, N.; Ducauze-Philippe, M.; Gaudefroy, L.; Gosselin, G.; Granier, T.; Hilaire, S.; Chau, Huu-Tai P.; Laborie, J. M.; Laurent, B.; Ledoux, X.; Le Luel, C.; Méot, V.; Morel, P.; Morillon, B.; Roig, O.; Romain, P.; Taieb, J.; Varignon, C.; Authier, N.; Casoli, P.; Richard, B.

2012-08-01

123

Vaccination of colorectal cancer patients with CEA-loaded dendritic cells: antigen-specific T cell responses in DTH skin tests  

Microsoft Academic Search

BACKGROUND: Dendritic cells (DCs) are the professional antigen-presenting cells of the immune system. As such they are currently used in clinical vaccination protocols in cancer patients. PATIENTS AND METHODS: We evaluated the ability of mature DCs pulsed with carcinoembryonic antigen (CEA)-peptide to induce CEA-specific T cell responses in patients with resectable liver metastases from colorectal cancer. CEA-specific T cell reactivity

W. J. Lesterhuis; I. J. M. de Vries; D. H. Schuurhuis; A. C. I. Boullart; J. F. M. Jacobs; A. J. de Boer; N. M. Scharenborg; H. M. H. Brouwer; M. W. M. M. van de Rakt; C. G. Figdor; T. J. M. Ruers; G. J. Adema; C. J. A. Punt

2006-01-01

124

Effets du décocté de Biophytum petersianum (Oxalidaceae) sur la libération du calcium du réticulum sarcoplasmique des cellules musculaires squelettiques  

Microsoft Academic Search

Résumé  Le décocté de la plante entière de Biophytum petersianum (Oxalidaceae) est utilisé dans la médecine traditionnelle au Togo pour traiter l’hypertension artérielle. Le présent travail\\u000a évalue les effets du décocté de la plante entière de Biophytum petersianum sur la libération du calcium stocké dans le réticulum sarcoplasmique des cellules musculaires squelettiques. Les résultats\\u000a ont montré qu’en présence du décocté, la

A. P. Mouzou; S. Titrikou; B. Constantin; S. Sebille; C. Cognard; M. Gbeassor; G. Raymond

2010-01-01

125

Plasma studies on electron cyclotron resonance light ion source at CEA/Saclay  

SciTech Connect

By the 90s, the CEA has undertaken to develop the production of intense light ion beams from unconfined ECR plasma. Today, three sources for IPHI, SPIRAL2, and IFMIF projects (respectively, 100 mA of H{sup +}, 8 mA of D{sup +}, and 140 mA of D{sup +}) are installed at CEA/Saclay. In order to improve performances and decrease dimensions of these sources, it is necessary to better understand the mechanisms involved in the production and extraction of particles. As a consequence, theoretical and experimental studies are being carried out. We present a theoretical study based on SOLMAXP, a home-made particle-in-cell code. The aim is to investigate the possibility of reducing the plasma chamber size without loss of beam characteristics. This code has been validated by beam intensity measurements on a permanent magnet based source, producing a proton beam of 30 mA at 40 kV on the test bench BETSI. In order to reduce experimentally the dimensions of plasma chamber, a new source, named ALISES with variable plasma chamber volume, is under assembly.

Nyckees, S.; Delferriere, O.; Duperrier, R.; Harrault, F.; Tuske, O. [CEA/Saclay, DSM/IRFU/SACM/LEDA, F-91191-Gif/Yvette (France)

2012-02-15

126

High intensity ECR ion source (H+, D+, H-) developments at CEA/Saclay  

NASA Astrophysics Data System (ADS)

Source of light ions with high intensities The (SILHI) source has been producing proton beams since 1996. The first aim is to produce up to 100 mA cw beams at 95 keV for the injector of protons for high intensity demonstrator. This prototype is developed by a CEA/DSM-CNRS/IN2P3 collaboration for applications such as accelerator driven systems for nuclear waste transmutation, production of radioactive ion beams, or secondary particles. To measure installation reliability, continuous 5 day long runs have been performed. In October 1999, a 99.96% availability was achieved with a single short beam off and a 103 H uninterrupted beam. A new extraction system leads to lower beam losses and higher LEBT transparency. SILHI now produces a 95 keV-130 mA total beam with a proton fraction higher than 80%. Up to a 157 mA (247 mA/cm2) total cw beam has been extracted. The new EPICS control system, electromagnetic interference hardened devices and automatic control procedures now allow us to do longer runs. To analyze the reliability of these upgrades, a 4 week test was planned. In the framework of the International Fusion Material Irradiation Facility project CEA participation, 135 mA-95 kV deuteron pulsed beams were produced. Extraction simulations and recent SILHI results are also presented. In addition, a new test bench has been recently developed to analyze H- beam production.

Gobin, R.; Beauvais, P.-Y.; Bogard, D.; Charruau, G.; Delferrière, O.; Menezes, D. De; France, A.; Ferdinand, R.; Gauthier, Y.; Harrault, F.; Jannin, J.-L.; Lagniel, J.-M.; Leroy, P.-A.; Mattéi, P.; Sherman, J.; Sinanna, A.; Ausset, P.; Bousson, S.; Pottin, B.

2002-02-01

127

Overview of studies and developments in cinematography, optoelectronic imaging and photonics at CEA/DIF  

NASA Astrophysics Data System (ADS)

This paper gives an overview of works undertaken at CEA/DIF in high speed cinematography, optoelectronic imaging and ultrafast photonics for the needs of the CEA/DAM experimental programs. We have developed a new multichannel velocimeter, and a new probe for shock breakout timing measurements in detonics experiments. A brief description and a recall of their main performances will be made. We have implemented three new optoelectronic imaging systems, in order to observe dynamic scenes in the ranges of 50 - 100 keV and 4 MeV. These systems are described, their main specifications and performances are given. Then we describe our contribution to the ICF program: after recalling the specifications of LIL plasma diagnostics, we describe the features and performances of visible streak tubes, X-ray streak tubes, visible and X-ray framing cameras and the associated systems developed to match these specifications. At last we introduce the subject of components and systems vulnerability in the LMJ target area, the principles identified to mitigate this problem and the first results of studies (image relay, response of streak tube phosphors, MCP image intensifiers and CCDs to fusion neutrons) related to this subject. Results obtained so far are presented.

Mens, Alain; Alozy, Eric; Aubert, Damien; Bénier, Jacky; Bourgade, Jean-Luc; Boutin, Jean-Yves; Brunel, Patrick; Charles, Gilbert; Chollet, Clément; Desbat, Laurent; Gontier, Dominique; Jacquet, Henri-Patrick; Jasmin, Serge; Le Breton, Jean-Pierre; Marchet, Bruno; Masclet-Gobin, Isabelle; Mercier, Patrick; Millier, Philippe; Missault, Carole; Nègre, Jean-Paul; Paul, Serge; Rosol, Rodolphe; Sommerlinck, Thierry; Veaux, Jacqueline; Véron, Laurent; Vincent de Araujo, Manuel; Jaanimagi, Paul; Pien, Greg

2003-07-01

128

Aeroacoustics research in Europe: The CEAS-ASC report on 2010 highlights  

NASA Astrophysics Data System (ADS)

The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, “aeroacoustics” encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe.This paper is a report on highlights of aeroacoustics research in Europe in 2010, compiled from information provided to the ASC of the CEAS.At the end of 2010, project X-NOISE EV of the Seventh Framework Programme of the European Commission has been launched as a continuation of the X-Noise series, with objectives of reducing aircraft noise and reaching the goal set by the ACARE 2020 Vision.Some contributions submitted to the editor summarizes selected findings from European projects launched before or concluded in 2010, while other articles cover issues supported by national associations or by industries. Furthermore, a concise summary of the workshop on “Aeroacoustics of High-Speed Aircraft Propellers and Open Rotors” held in Warsaw in October is included in this report.Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

Balázs Nagy, Attila

2011-10-01

129

Radioimmunoimaging of metastatic medullary carcinoma of the thyroid gland using an indium-111-labeled monoclonal antibody to CEA  

SciTech Connect

Elevated levels of carcinoembryonic antigen (CEA) or calcitonin after surgical therapy for medullary carcinoma of the thyroid gland (MCT) indicate the presence of residual or metastatic disease. CEA elevations appear to be prognostically more reliable in patients with metastatic disease and suggest a more virulent tumor. Attempts to stage the disease with use of conventional imaging techniques are usually inadequate, as is the therapy for disseminated or recurrent MCT. An indium-111-labeled anti-CEA monoclonal antibody (ZCE-025) was used to image metastases in a patient with MCT. Potential applications of monoclonal antibody technology in the management of MCT would include (1) preoperative differentiation of unicentric from multicentric thyroid gland involvement, (2) detection of regional or distant metastases or both, (3) measurement of response to systemic therapy, and (4) the facilitation of radionuclide immunoconjugate therapy.

Edington, H.D.; Watson, C.G.; Levine, G.; Tauxe, W.N.; Yousem, S.A.; Unger, M.; Kowal, C.D.

1988-12-01

130

Comparison of TPS with CEA and CA 15.3 in follow-up of Chinese breast cancer patients.  

PubMed

Serum levels of serum tissue polypeptide specific antigen (TPS) were compared with levels of carcinoembryonic antigen (CEA) and CA 15.3 with regards to their clinical values in Chinese breast cancer patients. A total of 81 patients were recruited and followed-up prospectively for disease recurrence and death. The median of follow-up was 33.1 months. CEA and CA15.3 correlated with the prognostic factors associated with poor prognosis. CA15.3 was associated with disease-free survival and overall survival. Multivariate analyses showed that the pre-operational serum CA15.3 level was an independent prognostic factor for disease-free survival. However, TPS was associated with neither prognostic factors nor patient survival. In conclusion, TPS is not a good serum tumor marker for breast cancer of Chinese patients, compared with CEA and CA 15.3. PMID:12168883

Hu, Xi-Chun; Day, Weida; Jones, Brian; Loo, Wings T Y; Chow, Louis W C

131

Biokinetics and dosimetry of depleted uranium (DU) in rats implanted with DU fragments  

Microsoft Academic Search

A number of U. S. veterans of the Persian Gulf War were wounded with depleted uranium (DU) metal fragments as a result of 'friendly fire' incidents, in which Abrams tanks and Bradley fighting vehicles were struck by DU anti-armor munitions. Some of the crew members who survived were left with multiple small fragments of DU in their muscles and soft

Ray A. Guilmette; Fletcher F. Hahn; P. W. Durbin

2004-01-01

132

Le dépistage précoce du cancer utérin  

Microsoft Academic Search

Résumé Pour Être efficace, un programme de dépistage du cancer du col par la cytologie doit remplir certaines conditions. En premier lieu, tous les actes techniques doivent Être de première qualité. Le praticien doit se rendre compte du rÔle important qu'il y joue, en particulier en prélevant de faÇon correcte un matériel représentatif avec lequel il devra préparer un frottis

G. Riotton

1983-01-01

133

[Sensitivity and specificity of CEA, Ca 15-3 and MCA levels in visceral breast carcinoma metastasis].  

PubMed

The determination of mucin like carcinoma associated antigen (MCA) showed a sensitivity of 72% in visceral metastasis of breast cancer, of 25% in metastasis of stomach cancer and of 10.3% in metastasis of colorectal cancer. The sensitivity of CA 15-3 was 83% (n.s.) in metastasis of breast cancer, that of CEA was 29% (p less than 0.05). The sensitivity of isolated metastasis and isolated invasion of the lymph nodes was under 20% for MCA, CA 15-3 and CEA. PMID:2200152

Delbrück, H; Hagen-Aukamp, C; Braun, G

1990-07-01

134

Novel Carcinoembryonic-Antigen-(CEA)Specific Pretargeting System to Assess Tumor Cell Viability after Irradiation of Colorectal Cancer Cells  

Microsoft Academic Search

\\u000a Abstract\\u000a \\u000a \\u000a Purpose:\\u000a   To date, no valid imaging modality exists for early response prediction to neoadjuvant radiochemotherapy in carcinoembryonic-antigen-(CEA)-expressing\\u000a rectal cancers (UICC stages II and III). It is hypothesized that the uptake of an anti-CEA\\u000a antibody is directly related to the number of viable tumor cells and may be quantified by immuno-positron emission tomography\\u000a (immuno-PET). Therefore, we evaluated a novel pretargeting

Birgit Meller; Margarete Rave-Fränck; Christian Breunig; Markus Schirmer; Manfred Baehre; Roger Nadrowitz; Torsten Liersch; Johannes Meller

2011-01-01

135

Prognostic value of preoperative CEA, CA 19-9, CA 72-4, and AFP levels in gastric cancer  

Microsoft Academic Search

Introduction  Recent research has suggested that serum tumor markers can give valuable prognostic information in gastric cancer. In this\\u000a study, we examined the relationship between preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 19-9,\\u000a CA 72-4, and alfa fetoprotein (AFP) levels on clinicopathologic significance in gastric cancer patients.\\u000a \\u000a \\u000a \\u000a Methods  Preoperative plasma levels of CEA, CA 19-9, CA 72-4, and AFP were retrospectively

Edip Ucar; Ersan Semerci; Hasan Ustun; Tugba Yetim; Can Huzmeli; Murat Gullu

2008-01-01

136

Architecture du paysage et carrieres  

Microsoft Academic Search

Résumé  La sensibilité aux problèmes d'environnement et notamment de paysage s'est accrue ces dernières années, permettant parfois\\u000a une meilleure gestion du partrimoine naturel, mais conduisant souvent à des refus inconditionnels face à des activités pourtant\\u000a indispensables à chacun, comme les extractions de matériaux.\\u000a \\u000a Le paysage, résultat de l'interaction entre la nature et les activités humaines, possède un caractére évolutif. Son analyse,

A. Merighi; C. Beranger; D. Lambert; C. Soubourou

1984-01-01

137

Une problematique de developpement local: l'evolution des relations villes-ports dans un nouveau contexte  

Microsoft Academic Search

Internationalisation, mutation du systeme productif (fin du fordisme), evolutions technologiques dans les transports et les telecommunications, emergence de reseaux de ville et d'entreprises, modification de la morphologie et de la culture urbaines, telles sont quelques unes des caracterisques de la metropolisation. La metropolisation peut etre ainsi presentee comme une reponse territoriale au processus de mondialisation\\/globalisation. La premiere hypothese de ce

G. Planque

1998-01-01

138

Specifically Targeted Killing of Carcinoembryonic Antigen (CEA)-expressing Cells by a Retroviral Vector Displaying Single-Chain Variable Fragmented Antibody to CEA and Carrying the Gene for Inducible Nitric Oxide Synthase1  

Microsoft Academic Search

The generation of retroviral vectors that infect specific cell types through recognition of cell surface antigens is a promising and effective approach to targeted gene therapy of cancer. Carcinoembryonic antigen (CEA), a highly characterized, cell surface glycoprotein overexpressed by various tumor cells, provides a specific tool for tumor tissue-specific targeting by retroviral vectors. The conventional suicidal gene delivery systems need

Pranay D. Khare; Liao Shao-Xi; Motomu Kuroki; Yumiko Hirose; Fumiko Arakawa; Ken Nakamura; Yoshihiro Tomita; Masahide Kuroki

2001-01-01

139

The effect of transfection of the CEA gene on the metastatic behavior of the human colorectal cancer cell line MIP101  

Microsoft Academic Search

Carcinoembryonic antigen (CEA) has been shown to increase the metastatic potential of some human colorectal cancer cell lines. To investigate further the mechanisms involved we have produced three clones (6, 8 and 17) from the poorly differentiated human colorectal cancer cell line MIP-101 that have been transfected with the full length cDNA encoding for human carcinoembryonic antigen (CEA). They produce

Peter Thomas; Aniruddha Gangopadhyay; Glenn Steele; Charles Andrews; Hiroshi Nakazato; Shinzo Oikawa; J. Milburn Jessup

1995-01-01

140

Usefulness of Serum Carcinoembryonic Antigen (CEA) in evaluating response to chemotherapy in patients with advanced non small-cell lung cancer: a prospective cohort study  

PubMed Central

Background High serum carcinoembryonic antigen (CEA) levels are an independent prognostic factor for recurrence and survival in patients with non-small cell lung cancer (NSCLC). Its role as a predictive marker of treatment response has not been widely characterized. Methods 180 patients with advanced NSCLC (stage IIIB or Stage IV), who had an elevated CEA serum level (>10 ng/ml) at baseline and who had no more than one previous chemotherapy regimen, were included. CEA levels were measured after two treatment cycles of platinum based chemotherapy (93%) or a tyrosine kinase inhibitor (7%). We assessed the change in serum CEA levels and the association with response measured by RECIST criteria. Results After two chemotherapy cycles, the patients who achieved an objective response (OR, 28.3%) had a reduction of CEA levels of 55.6% (95% CI 64.3-46.8) compared to its basal level, with an area under the ROC curve (AURC) of 0.945 (95% CI 0.91-0.99), and a sensitivity and specificity of 90.2 and 89.9%, respectively, for a CEA reduction of ?14%. Patients that achieved a decrease in CEA levels ?14% presented an overall response in 78% of cases, stable disease in 20.3% and progression in 1.7%, while patients that did not attain a reduction ?14% had an overall response of 4.1%, stable disease of 63.6% and progression of 32.2% (p?CEA levels of 9.4% (95% CI 1.5-17.3) and 87.5% (95% CI 60.9-114) from baseline, respectively (p?CEA increase of ?18%. PFS was longer in patients with a ?14% reduction in CEA (8.7 vs. 5.1 months, p?CEA was not predictive of OS. Conclusions A CEA level reduction is a sensitive and specific marker of OR, as well as a sensitive indicator for progression to chemotherapy in patients with advanced NSCLC who had an elevated CEA at baseline and had received no more than one chemotherapy regimen. A 14% decrease in CEA levels is associated with a longer PFS.

2013-01-01

141

Results of the CEA/Saclay H electron cyclotron resonance ion source, ECRIN  

NASA Astrophysics Data System (ADS)

A 2.45 GHz electron cyclotron resonance test stand based on a pure volume H- (negative) ion production is actually under development at CEA Saclay. The negative ion source is working in a pulsed mode, 2 ms at 5-10 Hz. The first H- ions have been observed at the beginning of 2002 with a poor efficiency: only a few microamperes were produced. Several changes inside the plasma chamber have increased the production rate of negative ions up to several milliamperes. A biased grid separates the plasma chamber into two regions. In the first part, we produce excited H2 molecules that are necessary for producing in the second zone H- ions by a dissociative attachment process located near the extraction zone. Qualitative and quantitative beam diagnostics allow measuring several beam parameters and analyzing the effect of gas mixing or materials on the H- production rate.

Tuske, O.; Delferrière, O.; Gobin, R.; Harrault, F.; Steiner, T.

2006-03-01

142

BAGHEERA: A new experimental facility at CEA / Valduc for actinides studies under high dynamic loading  

NASA Astrophysics Data System (ADS)

This paper is a technical presentation about a new experimental facility recently developed at CEA/Valduc, BAGHEERA, a French acronym for “Hopkinson And High Speed Experiments Glove Box”. This facility is used since mid-2003 to characterize the physical and mechanical behaviour of actinides under high dynamic loadings. For this purpose, four basic experimental devices are confined inside a single glove box: a 50?mm bore diameter single stage light gas gun, two compression and torsion split Hopkinson bars (SHPB and TSHB respectively) and a Taylor test device (TTD). Design and technical data on the experimental equipment are addressed, with a particular emphasis on the gas gun specific features due to actinide applications.

Roy, G.; Llorca, F.; Lanier, G.; Lamalle, S.; Beaulieu, J.; Antoine, P.; Martinuzzi, P.

2006-08-01

143

2010 CRITICALITY ACCIDENT ALARM SYSTEM BENCHMARK EXPERIMENTS AT THE CEA VALDUC SILENE FACILITY  

SciTech Connect

Several experiments were performed at the CEA Valduc SILENE reactor facility, which are intended to be published as evaluated benchmark experiments in the ICSBEP Handbook. These evaluated benchmarks will be useful for the verification and validation of radiation transport codes and evaluated nuclear data, particularly those that are used in the analysis of CAASs. During these experiments SILENE was operated in pulsed mode in order to be representative of a criticality accident, which is rare among shielding benchmarks. Measurements of the neutron flux were made with neutron activation foils and measurements of photon doses were made with TLDs. Also unique to these experiments was the presence of several detectors used in actual CAASs, which allowed for the observation of their behavior during an actual critical pulse. This paper presents the preliminary measurement data currently available from these experiments. Also presented are comparisons of preliminary computational results with Scale and TRIPOLI-4 to the preliminary measurement data.

Miller, Thomas Martin [ORNL; Dunn, Michael E [ORNL; Wagner, John C [ORNL; McMahan, Kimberly L [ORNL; Authier, Nicolas [CEA-Centre de Valduc, Is-sur-Tille, France; Jacquet, Xavier [CEA-Centre de Valduc, Is-sur-Tille, France; Rousseau, Guillaume [CEA-Centre de Valduc, Is-sur-Tille, France; Wolff, Herve [CEA-Centre de Valduc, Is-sur-Tille, France; Piot, Jerome [CEA-Centre de Valduc, Is-sur-Tille, France; Savanier, Laurence [CEA-Centre de Valduc, Is-sur-Tille, France; Baclet, Nathalie [CEA-Centre de Valduc, Is-sur-Tille, France; Lee, Yi-kang [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Masse, Veronique [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Trama, Jean-Christophe [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Gagnier, Emmanuel [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Naury, Sylvie [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Lenain, Richard [CEA, Cetre de Sacaly, Gif-sur-Yvette, France; Hunter, Richard [Babcock International Group, United Kingdom; Kim, Soon [Lawrence Livermore National Laboratory (LLNL); Dulik, George Michael [Lawrence Livermore National Laboratory (LLNL); Reynolds, Kevin H. [Y-12 National Security Complex

2011-01-01

144

Science and technology research and development in support to ITER and the Broader Approach at CEA  

NASA Astrophysics Data System (ADS)

In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented. Commissariat à l'Energie Atomique et aux énergies alternatives.

Bécoulet, A.; Hoang, G. T.; Abiteboul, J.; Achard, J.; Alarcon, T.; Alba-Duran, J.; Allegretti, L.; Allfrey, S.; Amiel, S.; Ané, J. M.; Aniel, T.; Antar, G.; Argouarch, A.; Armitano, A.; Arnaud, J.; Arranger, D.; Artaud, J. F.; Audisio, D.; Aumeunier, M.; Autissier, E.; Azcona, L.; Back, A.; Bahat, A.; Bai, X.; Baiocchi, B.; Balaguer, D.; Balme, S.; Balorin, C.; Barana, O.; Barbier, D.; Barbuti, A.; Basiuk, V.; Baulaigue, O.; Bayetti, P.; Baylard, C.; Beaufils, S.; Beaute, A.; Bécoulet, M.; Bej, Z.; Benkadda, S.; Benoit, F.; Berger-By, G.; Bernard, J. M.; Berne, A.; Bertrand, B.; Bertrand, E.; Beyer, P.; Bigand, A.; Bonhomme, G.; Borel, G.; Boron, A.; Bottereau, C.; Bottollier-Curtet, H.; Bouchand, C.; Bouquey, F.; Bourdelle, C.; Bourg, J.; Bourmaud, S.; Brémond, S.; Bribiesca Argomedo, F.; Brieu, M.; Brun, C.; Bruno, V.; Bucalossi, J.; Bufferand, H.; Buravand, Y.; Cai, L.; Cantone, V.; Cantone, B.; Caprin, E.; Cartier-Michaud, T.; Castagliolo, A.; Belo, J.; Catherine-Dumont, V.; Caulier, G.; Chaix, J.; Chantant, M.; Chatelier, M.; Chauvin, D.; Chenevois, J.; Chouli, B.; Christin, L.; Ciazynski, D.; Ciraolo, G.; Clairet, F.; Clapier, R.; Cloez, H.; Coatanea-Gouachet, M.; Colas, L.; Colledani, G.; Commin, L.; Coquillat, P.; Corbel, E.; Corre, Y.; Cottet, J.; Cottier, P.; Courtois, X.; Crest, I.; Dachicourt, R.; Dapena Febrer, M.; Daumas, C.; de Esch, H. P. L.; De Gentile, B.; Dechelle, C.; Decker, J.; Decool, P.; Deghaye, V.; Delaplanche, J.; Delchambre-Demoncheaux, E.; Delpech, L.; Desgranges, C.; Devynck, P.; Dias Pereira Bernardo, J.; Dif-Pradalier, G.; Doceul, L.; Dong, Y.; Douai, D.; Dougnac, H.; Dubuit, N.; Duchateau, J.-L.; Ducobu, L.; Dugue, B.; Dumas, N.; Dumont, R.; Durocher, A.; Durocher, A.; Duthoit, F.; Ekedahl, A.; Elbeze, D.; Escarguel, A.; Escop, J.; Faïsse, F.; Falchetto, G.; Farjon, J.; Faury, M.; Fedorzack, N.; Féjoz, P.; Fenzi, C.; Ferlay, F.; Fiet, P.; Firdaouss, M.; Francisquez, M.; Franel, B.; Frauche, J.; Frauel, Y.; Futtersack, R.; Garbet, X.; Garcia, J.; Gardarein, J.; Gargiulo, L.; Garibaldi, P.; Garin, P.; Garnier, D.; Gauthier, E.; Gaye, O.; Geraud, A.; Gerome, M.; Gervaise, V.; Geynet, M.; Ghendrih, P.; Giacalone, I.; Gibert, S.; Gil, C.; Ginoux, S.; Giovannangelo, L.; Girard, S.; Giruzzi, G.; Goletto, C.; Goncalves, R.; Gonde, R.; Goniche, M.; Goswami, R.; Grand, C.; Grandgirard, V.; Gravil, B.; Grisolia, C.; Gros, G.; Grosman, A.; Guigue, J.; Guilhem, D.; Guillemaut, C.; Guillerminet, B.; Guimaraes Filho, Z.; Guirlet, R.; Gunn, J. P.; Gurcan, O.; Guzman, F.; Hacquin, S.; Hariri, F.; Hasenbeck, F.; Hatchressian, J. C.; Hennequin, P.; Hernandez, C.; Hertout, P.; Heuraux, S.; Hillairet, J.; Honore, C.; Hornung, G.; Houry, M.; Hunstad, I.; Hutter, T.; Huynh, P.; Icard, V.; Imbeaux, F.; Irishkin, M.; Isoardi, L.; Jacquinot, J.; Jacquot, J.; Jiolat, G.; Joanny, M.; Joffrin, E.; Johner, J.; Joubert, P.; Jourd'Heuil, L.; Jouve, M.; Junique, C.; Keller, D.; Klepper, C.; Kogut, D.; Kubi?, M.; Labassé, F.; Lacroix, B.; Lallier, Y.; Lamaison, V.; Lambert, R.; Larroque, S.; Latu, G.; Lausenaz, Y.; Laviron, C.; Le, R.; Le Luyer, A.; Le Niliot, C.; Le Tonqueze, Y.; Lebourg, P.; Lefevre, T.; Leroux, F.; Letellier, L.; Li, Y.; Lipa, M.; Lister, J.; Litaudon, X.; Liu, F.; Loarer, T.; Lombard, G.; Lotte, P.; Lozano, M.; Lucas, J.; Lütjens, H.; Magaud, P.; Maget, P.; Magne, R.; Mahieu, J.-F.; Maini, P.; Malard, P.; Manenc, L.; Marandet, Y.; Marbach, G.; Marechal, J.-L.; Marfisi, L.; Marle, M.; Martin, C.; Martin, V.; Martin, G.; Martinez, A.; Martino, P.; Masset, R.; Mazon, D.; Mellet, N.; Mercadier, L.; Merle, A.; Meshcheriakov, D.; Messina, P.; Meyer, O.; Millon, L.; Missirlian, M.; Moerel, J.; Molina, D.; Mollard, P.; Moncada, V.; Monier-Garbet, P.; Moreau, D.; Moreau, M.; Moreau, P.; Morel, P.; Moriyama, T.; Motassim, Y.; Mougeolle, G.; Moulton, D.; Moureau, G.; Mouyon, D.; Naim Habib, M.; Nardon, E.; Négrier, V.; Nemeth, J.; Nguyen, C.; Nguyen, M.; Nicolas, L.; Nicolas, T.; Nicollet, S.; Nilsson, E.; N'Konga, B.; Noel, F.; Nooman, A.; Norscini, C.; Nouailletas, R.; Oddon, P.; Ohsako, T.; Orain, F.; Ottaviani, M.; Pagano, M.; Palermo, F.; Panayotis, S.; Parrat, H.; Pascal, J.-Y.; Passeron, C.; Pastor, P.; Patterlini, J.; Pavy, K.; Pecquet, A.-L.; Pégourié, B.; Peinturier, C.; Pelletier, T.; Peluso, B.; Petrzilka, V.; Peysson, Y.; Pignoly, E.; Pirola, R.; Pocheau, C.; Poitevin, E.; Poli, V.; Poli, S.; Pompon, F.; Porchy, I.; Portafaix, C.; Preynas, M.; Prochet, P.; Prou, M.; Ratnani, A.; Raulin, D.; Ravenel, N.; Renard, S.; Ricaud, B.; Richou, M.; Ritz, G.; Roche, H.; Roubin, P.; Roux, C.; Ruiz, K.; Sabathier, F.; Sabot, R.; Saille, A.; Saint-Laurent, F.; Sakamoto, R.; Salasca, S.; Salmon, T.; Salmon, T.; Samaille, F.; Sanchez, S.; Santagiustina, A.; Saoutic, B.; Sarazin, Y.; Sardain, P.; Schlosser, J.

2013-10-01

145

Recent progress on minor-actinide-bearing oxide fuel fabrication at CEA Marcoule  

NASA Astrophysics Data System (ADS)

Partitioning and transmutation (P&T) of minor actinides (MA: americium, neptunium and curium) in fast neutron reactors or accelerator-driven systems is a route envisaged to reduce nuclear waste inventory. Over the years, several modes of P&T were proposed, each being based on the use of dedicated fuels such as inert-matrix fuels, MA-bearing MOX or MA-bearing blankets. In this context, progress on the manufacturing of such fuels is a key-challenge in order to render P&T viable at the industrial scale. Here, MA-bearing oxide fuel fabrication and characterization conducted in the CEA Marcoule Atalante facility is reviewed. A particular attention is also given to the research conducted on uranium–americium mixed-oxides fuels, which are now considered the reference fuels for MA transmutation in France.

Lebreton, Florent; Prieur, Damien; Horlait, Denis; Delahaye, Thibaud; Jankowiak, Aurélien; Léorier, Caroline; Jorion, Frédéric; Gavilan, Elisabeth; Desmoulière, François

2013-07-01

146

Free cancer cell detection in peritoneal cavity in gastric cancer patients by RT-PCR for CEA.  

National Technical Information Service (NTIS)

Authors applied RT-PCR assay to detecting CEA expressing free cancer cells in peritoneal cavity of 114 gastric cancer patients to find an indication for prophylactic treatment to prevent peritoneal recurrence. Sixty-three of 114 cases were positive for RT...

J. I. Lee N. M. Moon N. S. Paik D. W. Choi H. Y. Bang

1997-01-01

147

Restaging of colorectal cancer based on the identification of lymph node micrometastases through immunoperoxidase staining of CEA and cytokeratins  

Microsoft Academic Search

The present study was performed to identify tumor cells in lymph nodes from colorectal adenocarcinomas considered free of disease by the classic hematoxylin-eosin stain, based on the detection of the carcinoembryonic antigen (CEA) and cytokeratins in neoplastic epithelial cells. For this purpose, 603 lymph nodes from 46 lesions were stained by the peroxidase-antiperoxidase technique. Tumor cells were detected in 22

Raul Cutait; Venfincio A. F. Alves; Luiz Cfimara Lopes; Daher E. Cutait; José Luiz A. Borges; JÚlio Singer; José Hyppólito da Silva; Fábio S. Goffi

1991-01-01

148

Ultra low dark current CdHgTe FPAs in the SWIR range at CEA and Sofradir  

Microsoft Academic Search

We report here first results carried out at CEA and Sofradir to build ultra low dark current focal plane arrays (FPA) in the short wave infrared range (SWIR) for space applications. Those FPAs are dedicated to very low flux detection in the 2mum wavelength range. In this purpose, Sofradir has designed a source follower per detector readout circuit (ROIC), 384x288,

O. Gravrand; L. Mollard; O. Boulade; V. Moreau; E. Sanson; G. Destéfanis

2011-01-01

149

Monitoring the Flash Cryomodule Transportation From DESY Hamburg to CEA Saclay: Coupler Contact, Vacuum Acceleration and Vibration Analysis.  

National Technical Information Service (NTIS)

With a view to the series production of one hundred, 12 m long XFEL 1.3 GHz cryomodules and their transportation from the assembly site at CEA Saclay (F) to the installation site at DESY Hamburg (D) a test transportation of a FLASH cryomodule has been per...

A. Bertolini A. Bosotti M. Fusetti P. Michelato S. Barbanotti

2009-01-01

150

FDG-PET scan in patients with clinically and/or radiologically suspicious colorectal cancer recurrence but normal CEA  

PubMed Central

Background Although frequently used for tumor surveillance, the sensitivity of carcinoembryonic antigen (CEA) to detect recurrent colorectal cancer (CRC) is not optimal. Fluorine 18-fluoro-2-deoxy-glucose-positron emission tomography (18F FDG-PET) scans promise to improve recurrent CRC detection. We aimed to review PET scans of patients with clinically and/or radiologically suspicious tumor recurrence but normal CEA. Methods A retrospective review of an electronic database of 308 patients with CRC who had PET scans was performed. Only PET studies of patients with normal CEAs and suspected tumor recurrence who had pathological verification were selected for further analysis. Thirty-nine patients met the inclusion criteria. Results PET was positive in 26 patients (67%) and normal in 13 (33%). Histopathologic evidence of tumor recurrence was seen in 27 of the 39 patients (69%). When correlated with histopathology, PET was true positive in 22 patients, false positive in 4, true negative in 8 and false negative in 5. Overall, the accuracy of PET was 76.9%, negative predictive value (NPV) was 61.5%, and positive predictive value (PPV) was 84.6%. PPV value of PET for liver metastases was 88.8% compared to 73.3% for local recurrence. In two patients with confirmed recurrence, CEA became positive 2 months after PET scan indicating earlier detection of disease with PET. The false positive PET findings were mainly in the bowel and were secondary to acute/chronic inflammation and granulation tissue. In 3 patients with false negative PET, histopathology was consistent with mucinous adenocarcinoma. Conclusion PET yields high PPV for recurrent CRC, particularly for liver metastases, in spite of normal CEA levels and should be considered early in the evaluation of patients with suspected tumor recurrence.

Sarikaya, Ismet; Bloomston, Mark; Povoski, Stephen P; Zhang, Jun; Hall, Nathan C; Knopp, Michael V; Martin, Edward W

2007-01-01

151

Characterisation of DU Particles from Kosovo and Kuwait  

Microsoft Academic Search

Large amounts of DU material has been released to the environmentin Kosovo and Kuwait due to the use of depleted uranium (DU)\\u000a ammunitionduring the 1991 Gulf war and the 1999 Balkan conflict. Following the impact ofmetallic DU penetrators on solid targets,\\u000a DU particles are dispersed and ignited,and uranium in the particles is oxidized. Following inhalation or ingestion ofDU particles,\\u000a the

Ole Christian Lind; Brit Salbu; Koen Janssens; Kristof Proost; Pier Roberto Danesi

152

La cosmologie de Kant dans l'Histoire générale de la Nature et théorie du ciel (1755).  

NASA Astrophysics Data System (ADS)

In his scientifical works Newton was not in position to solve the cosmological problems without calling on the help of God's Providence: for instance, the structure of the universe, its stability, the problem of its origin, of its process of formation, of its evolution. For the first time in the history of astronomy, Kant's Universal Natural History and Theory of the Heavens (1755) conceived correctly the structure of our Galaxy, and then developped the famous theory of "Island Universes". In the second part of this article the author gives a survey of the nebular hypothesis developped by Kant 40 years before Laplace's Exposition du système du Monde.

Seidengart, J.

153

Variete Technique du Lambeau Sural dans les Brulures Profondes du Pied  

PubMed Central

Summary Les couvertures des pertes de substance de la jambe, du talon et du pied font souvent appel au lambeau sural, qui reste, de part ses dimensions, une indication limitée. Les Auteurs présentent, à travers deux cas cliniques, une variété technique pour la levée du lambeau sural, permettant d'obtenir des palettes cutanées de grande surface avec une bonne sécurité vasculaire. C'est un lambeau fasciocutané remontant jusqu'à un centimètre du creux poplité et incluant, lors de la levée, l'aponévrose, le nerf sural, la petite veine saphène et le nerf sural latéral.

Ezzoubi, M.; Ettalbi, S.; Elmounjid, S.; Fassi, J.; Benchamckha, F.J.; Sakhi, M.; Boukind, E.

2005-01-01

154

The 400W at 1.8K Test Facility at CEA-Grenoble  

NASA Astrophysics Data System (ADS)

A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

2006-04-01

155

Assessment of a European V-4Cr-4Ti alloy - CEA-J57  

NASA Astrophysics Data System (ADS)

About 30 kg of 7 mm-thick plates (grade CEA-J57) were fabricated to support development of vanadium alloys for applications as structural components in future fast neutron fission reactors. After a stress relieve annealing at 973 K, the material exhibited elongated grains and large Ti-rich precipitates oriented in the rolling direction. After final heat-treatment of 2 h at 1273 K, the microstructure was fully recrystallised with remaining aligned large precipitates. Charpy V-notch and tensile specimens were machined in various directions of stress-relieved and recrystallised plates. The fracture energy and the lateral expansion were determined between 113 K and 598 K. Stress-relieved specimens clearly highlighted an anisotropic behavior with both ductile and brittle features while the recrystallized specimens are all ductile: a DBTT of 113 K is suggested. The fracture mode and morphology were related to the microstructure and especially to the Ti-rich precipitate distribution. Additionally, tensile tests were performed at room temperature and between 873 K and 1223 K. The results were consistent with previous results: after a plateau around 400 MPa, a significant decrease in tensile strength is observed above 1023 K. The fracture surfaces always exhibited ductile fracture mode. The present work suggests the good quality of this vanadium alloy.

Le Flem, Marion; Gentzbittel, Jean-Marie; Wident, Pierre

2013-11-01

156

Development of a permanent magnet light ion source at CEA/Saclay  

SciTech Connect

In France, the Spiral 2 project dedicated to radioactive beam production is based on a 40 MeV continuous wave (cw) deuteron Linac. This installation will allow extending the variety of accelerated particles to very heavy elements. Such beams will open research domains for the GANIL facility. To inject the requested 5 mA deuteron beam into the Spiral 2 Linac, the performance of the high intensity light ion source (SILHI) allowed us to propose such an electron cyclotron resonance source. SILHI, developed at CEA/Saclay, regularly produces high intensity (over 100 mA) proton or deuteron beams through a {phi} 9 mm aperture. So for this project, the main modifications of the source design concern the permanent magnets which provide the axial magnetic configuration and the {phi} 3 mm aperture. The source produced its first beam (proton) in 2004. This article will report the beam characterization while the source produced D{sup +} beam with intensity as high as 7.0 mA. Recently, this permanent magnet source has been equipped with the {phi} 9 mm plasma electrode. So high intensity proton beams reaching more than 100 mA are now extracted from this source.

Gobin, R.; Charruau, G.; Delferriere, O.; De Menezes, D.; Gauthier, Y.; Harrault, F.; Leherissier, P.; Pacquet, J. Y. [Commissariat a l'Energie Atomique, CEA-Saclay, DSM/DAPNIA, 91191 Gif sur Yvette Cedex (France); GANIL, Bd Henri Becquerel, 14076 Caen Cedex 5 (France)

2006-03-15

157

[Serum concentration of selected neoplasm markers: CA15-3, TPS and CEA in women with diagnosed breast benign disease].  

PubMed

The aim of the study was the assessment of serum concentrations of selected neoplasmatic markers: CA15-3, TPS and CEA in women with established diagnosis of benign breast disease (BBD) using hormone replacement therapy (HRT) for average 3 years. 120 women with BBD were divided to 2 groups: HRT-users (n1 = 24) and HRT-non-users (n2 = 96). 31 healthy, regularly menstruating, age-matched women served as control group. Concentrations of all markers were measured with immunoradiometric methods. In all groups serum concentrations of measured markers were within normal range. We conclude that hormone replacement therapy has no influence on serum concentrations of CA15-3, TPS and CEA. PMID:11082991

Kocha?ska-Dziurowicz, A; Pasich, R; Stanjek, A; Gawe?-Szostek, V; Jankowski, T

2000-09-01

158

Evolution of operations management: past, present and future  

Microsoft Academic Search

Purpose – This paper seeks to analyze the evolution of shift in the area of operations management (OM) and attempts to anticipate potential developments in the relevant areas of OM. \\u000d\\u000aDesign\\/methodology\\/approach – A hybrid approach is adopted to understand how the field of OM has evolved over time relying on the perspectives of both academics and business practitioners. This evolution

Erkan Bayraktar; M. C. Jothishankar; Ekrem Tatoglu; Teresa Wu

2007-01-01

159

Sécurité virale des produits dérivés du plasma  

Center for Biologics Evaluation and Research (CBER)

Text Version... Par exemple, certaines étapes de précipitation et de séparation dans le processus de fabrication des produits dérivés du plasma et des produits ... More results from www.fda.gov/downloads/biologicsbloodvaccines/internationalactivities

160

Charles Baudelaire's Fleurs du Mal  

NSDL National Science Digital Library

Charles Baudelaire was an acclaimed poet and translator, and during his life he produced works that explored the urban condition, psychological turmoil, and despondency. He took meticulous care when crafting his poems, and his first work, Les Fleurs Du Mal (The Flowers of Evil) was published in 1857 when he was 36. The work was later praised by Gustave Flaubert and Victor Hugo, but the French government took exception to some of the poems contained in the volume and banned them until 1949. This site provides interested parties with access to the complete contents of the 1857 edition, along with the 1861 edition. The site also contains audio recordings of the poems made by Eva Le Gallienne and Louis Jordan for Caedmon Records. The site is quite a find, and users with a penchant for Baudelaire's works will want to return several times.

161

CEA and AREVA R&D on HTR fuel fabrication and presentation of the CAPRI experimental manufacturing line  

Microsoft Academic Search

In the framework of the French V\\/HTR fuel development and qualification program, the Commissariat à l’Energie Atomique (CEA) and AREVA are conducting R&D projects covering the mastering of UO2 coated particle and fuel compact fabrication technology. To fulfill this task, a review of past knowledge, of existing technologies and a preliminary laboratory-scale work program have been conducted with the aim

François Charollais; Sophie Fonquernie; Christophe Perrais; Marc Perez; Olivier Dugne; François Cellier; Gérard Harbonnier; Marie-Pierre Vitali

2006-01-01

162

Multivariate analysis of a tissue CEA, TPA, and CA 19.9 quantitative study in colorectal cancer patients  

Microsoft Academic Search

Tissue CEA, TPA, and CA 19.9 concentrations from samples of surgical specimens were measured in 47 evaluable colorectal cancer\\u000a patients (median follow-up, 20 months, 13 recurrences) and correlated with individual patient follow-up status. The quantitative\\u000a method appeared to be sensitive, easily reproducible, and standardizable. The tissue marker concentration was analyzed by\\u000a means of the multivariate discriminant analysis, to evaluate the

Maurizio Cosimelli; Francesco De Peppo; Mauro Castelli; Diana Giannarelli; Giuseppe Schinaia; Paolo Castaldo; Giovanni L. Buttini; Francesco Sciarretta; Giulio Bigotti; Franco Di Filippo; Francesco Cavaliere; Renato Cavaliere

1989-01-01

163

The prognostic value of preoperative serum levels of CA 19-9 and CEA in patients with pancreatic cancer  

Microsoft Academic Search

The prognostic value of preoperative serum levels of CA 19-9 and CEA was evaluated in 160 patients with pancreatic cancer. The survival of patients whose tumour marker value was below a certain cut-off level was compared with the survival of those with a higher value using the log-rank test. The lowest cut-off level dividing patients into groups with significant difference

J Lundin; PJ Roberts; P Kuusela; C Haglund

1994-01-01

164

Evaluation of CEA, CA 19-9, CA50, CA195, and tati with special reference to pancreatic disorders  

Microsoft Academic Search

Summary  The tumor markers CEA, CA 19-9, CA-50, CA-195, and TATI were analyzed in patient, with pancreatic disease, a, well a, disorder,\\u000a in the upper quadrant of the abdomen. Two different method, for CA-50, namely CA-50 IRMA and CA-50 DELFIA, which are based\\u000a on the same monoclonal antibody, were used. The sensitivities, specificities, and predictive value, of positive and negative\\u000a result,

Parvesh Masson; Birger Pålsson; Åke Andrén-Sandberg

1991-01-01

165

Application of the New Decommissioning Regulation to the Nuclear Licensed Facilities (NLF) at Fontenay-aux-Roses's Nuclear Center (CEA)  

Microsoft Academic Search

This abstract describes the application of the new decommissioning regulation on all Nuclear Licensed Facilities (NLF is to say INB in French) at Fontenay-aux-Roses's Center (CEA\\/FAR). The decommissioning process has been applied in six buildings which are out of the new nuclear perimeter proposed (buildings no 7, no 40, no 94, no 39, no 52\\/1 and no 32) and three

Josiane Sauret; Laurence Piketty; Michel Jeanjacques

2008-01-01

166

Elements nerveux intracardiaques et innervation du myocarde  

Microsoft Academic Search

L'étude au microscope électronique des éléments nerveux intracardiaques et des rapports musculo-nerveux dans le coeur de rat nous a montré un certain nombre de particularités:1.Dans les ganglions nerveux du sulcus terminalis, on trouve des cellules particulières proches des éléments chémorécepteurs du corpuscule carotidien. Des cylindraxes renflés rappelant les corps de Herring se rencontrent prés de l'abouchement de l'aorte. Ils renferment

Sz. Virágh; A. Porte

1961-01-01

167

Auriculo. et troubles du sommeil (extraits)  

Microsoft Academic Search

\\u000a On admet que l’oreille peut réfléchir, en miroir, l’activité des organes. L’impact est régulateur : il permet de normaliser\\u000a l’équilibre autonome des divers étages du corps. L’activité du traitement réflexe est liée à sa grande précision : il fait\\u000a sécréter des neuromédiateurs sur le site correspondant au point traité.

Y. Rouxeville

168

Accuracy of differential diagnosis for pancreatic cancer is improved in the combination of RCAS1 and CEA measurements and cytology in pancreatic juice  

Microsoft Academic Search

Improvement of diagnostic accuracy for pancreatic cancer in pancreatic disease patients was investigated by examining the\\u000a combination of three diagnostic methods, i.e., measurements of RCAS1 and CEA levels in pancreatic juice and pancreatic juice\\u000a cytology. Pancreatic juice was collected from 12 pancreatic cancer (PC) and 26 non-PC patients. RCAS1 and CEA levels were\\u000a measured by using ELISA. RCAS1 expression on

Yoshiki Naito; Yoshinobu Okabe; Masakatsu Nagayama; Takuya Nishinakagawa; Tomoki Taira; Akihiko Kawahara; Satoshi Hattori; Kazuyuki Machida; Yusuke Ishida; Ryohei Kaji; Kazuhiro Mikagi; Hisafumi Kinoshita; Makiko Yasumoto; Jun Akiba; Masayoshi Kage; Manabu Nakashima; Koichi Ohshima; Hirohisa Yano

2011-01-01

169

16. FDG-PET in the Detection of Recurrence in Colorectal Cancer Based on Rising CEA Level. Experience in 72 Patients  

Microsoft Academic Search

Purpose: A rising CEA level after the resection of colorectal cancer is an early indicator of tumour recurrence. However, conventional imaging techniques have limited sensitivity for detecting recurrent disease in such patients. Our group has evaluated the role of Positron Emission Tomography with 18F-Fluorodeoxiglucose (FDG-PET) in this clinical situation.Material and Methods: Seventy-two patients with abnormal CEA levels and normal results

A Maldonado; F Sancho; J Cerdan; A Lozano; N Mohedano; J Jiménez; F Moya; M Zomeño

2000-01-01

170

Tissue concentrations of CEA and CA 19-9 in the carcinogenesis of colorectal carcinoma exemplified by the adenoma-carcinoma sequence  

Microsoft Academic Search

Summary To study the behavior of the tumor-associated antigens CEA and CA 19-9 in colorectal carcinogenesis, exemplified by the adenoma-carcinoma sequence, their tissue concentrations were measured in adenomas of different size and histology and compared with those found in normal colonic mucosa and carcinoma. Both in the case of monoclonal and polyclonal CEA assay, significantly higher concentrations were found in

W. Fischbach; J. Mössner

1988-01-01

171

[Recrudescent prostate cancer with a low serum PSA level and a high serum CEA level treated with docetaxel : a case report].  

PubMed

A 63-year-old man was hospitalized with an increased serum prostate specific antigen (PSA) level (72 ng/ml). A prostate biopsy was performed, and histological examinations indicated moderately and poorly differentiated adenocarcinoma with positive staining for carcinoembryonic antigen (CEA). The patient was diagnosed as having prostate cancer (clinical stage : T3bN0M0) and received radiotherapy and hormonal therapy. Five years after the diagnosis, the serum CEA level increased to 153.8 ng/dl, and the patient complained of abdominal pain. His serum PSA level remained normal (<0.1 ng/dl). Computed topography indicated multiple bone metastasis and the involvement of multiple lymph glands. A biopsy of a cervical lymph gland revealed poorly differentiated adenocarcinoma with positive staining for CEA. Gastrointestinal examination showed no evidence of abnormality. The diagnosis of metastatic prostate cancer was made, and docetaxel (60-70 mg/m2) was administered. Eight courses of docetaxel therapy led to an approximately 20% reduction in lymph volume, and the serum CEA level decreased. However, liver metastases developed 12 months later, and the patient died at 18 months after the diagnosis of metastatic prostate cancer with a high serum CEA level. We encountered a case of recrudescence of prostate cancer positive for CEA with a low serum PSA level and report the effect of docetaxel therapy for atypical prostatic carcinoma. PMID:23633635

Fujita, Masahiro; Goto, Takayasu; Uchida, Kinya; Saiki, Shigeru; Arima, Ryoichi

2013-03-01

172

CHRONIQUE POLITIQUE DU RWANDA ET DU BURUNDI, 2000-2001  

Microsoft Academic Search

The political evolution of Rwanda and Burundi must be seen in a broader regional geopolitical context. Indeed, the presence of the Rwandan and Burundian armies in the DRC is the expression of the extraterritorial extension of these countries' civil wars. While the Burundian armed conflict runs parallel to (very fragile) negotiations, the Rwandan regime remains closed to any idea of

Filip Reyntjens

173

Lymphome primitif du sein: ? propos d'un cas  

PubMed Central

Le lymphome primitif du sein est une entité histologique très rare du cancer du sein. Les aspects cliniques et radiologiques ne présentent pas de spécificités particulières. Le diagnostic est souvent retardé. Le traitement se base essentiellement sur la chimiothérapie. Le pronostic est globalement péjoratif. Nous rapportons un cas de lymphome malin non Hodgkinien primitif du sein chez une patiente de 38 ans. Parallèlement une revue de la littérature est entreprise évoquant les aspects épidémiologiques, cliniques, histologiques et thérapeutiques de ce néoplasme.

Njoumi, Noureddine; Najih, Mohamed; Haqqi, Laila; Atolou, Gilles; Bougtab, Abdessalm; Hachi, Hafid; Benjelloun, Samir

2012-01-01

174

Understanding Evolution  

NSDL National Science Digital Library

This site provides access to basic and advanced online resources for teaching the science and history of evolutionary biology. The resources are organized by topic: the mechanisms of evolution; the relevance of evolutionary theory to everyday life; lines of scientific evidence; and the history of ideas, research, and contributors in the study of evolution. For teachers, there are searchable databases of lesson plans, activities, and conceptual frameworks on the history of life, evidence for evolution, mechanisms of evolution, and the nature of science. Other materials include links to news items and highlighted features on specific evolution topics.

2004-02-06

175

Le maintien du tourbillon des ondes planétaires stationnaires  

Microsoft Academic Search

La dynamique des ondes planétaires stationnaires est étudiée à l'aide des données de la PEMG de janvier 1979. On a calculé et comparé les moyennes temporelles des divers termes de l'équation du tourbillon. La variance zonale des termes principaux atteint des maxima en trois régions : le flanc nord du courant jet stratosphérique, le centre et le flanc nord du

Bernard Dugas; Jacques Derome

1987-01-01

176

Émergence du marché concurrentiel et évolutionnisme chez Hayek  

Microsoft Academic Search

[fre] Émergence du marché concurrentiel et évolutionnisme chez Hayek. . Le trait le plus caractéristique de l'épistémologie hayékienne réside dans son parti pris sans réserve pour le point de vue évolutionniste contre le dogmatisme du rationalisme constructiviste. Selon Hayek, seule une méthode évolutionniste peut effectivement rendre compte de la genèse des ordres spontanés comme le marché concurrentiel. L'ordre du marché

Ragip Ege

1992-01-01

177

Major Upgrade of the Reactor Dosimetry Interpretation Methodology Used at the CEA General Principle  

NASA Astrophysics Data System (ADS)

One of the main objectives of reactor dosimetry is the determination of the physical parameters characterizing the neutron field in which test samples are irradiated. These characteristics, from neutron spectrum to reaction rates characterization are used in experimental reactors to carry out the follow-up of the irradiation and to qualify the neutron calculation used to model the experiment. In power reactors these characteristics are used for the follow-up of the predicted damages to vessel and interns. Neutron parameters are derived from the dosimeter's activities which have suitable reactions (response functions and radioactive emissions). Then, the activities are analyzed using nuclear data, neutron computation results and data characterizing the conditions of irradiation (temporal and technological data, changes of location, etc.). The current CEA interpretation process applied for industrial power reactor interpretation process presents limitations coming mainly from the calculational tools and the nuclear data knowledge available at the time this method was developed in the mid 90's. However nowadays due to, first the improvement of the neutron calculational tools, for example, a full 3D Monte Carlo reactor modeling providing reaction in a point wise format is now possible in a reasonable time, and second, recent releases of the updated international nuclear data libraries, JEFF3.1, ENDF/B-VII for transport calculation and IRDF2002 and EAF2007 for dosimetry libraries, we have been engaged in a deep renewal of the reactor dosimetry interpretation process. The mains goals of this works are to improve the modeling of the experiment and the neutron parameters calculation for each phase of interest. In addition, uncertainties associated to the derived metrics are quantified in a rigorous way using simulation methods designed to cope with the high non-linearity of the process. After a detailed presentation of the current interpretation process and its limitations, this paper lists the main improvements of the neutron calculation codes and of the international nuclear data libraries. The principle of the new interpretation process is then detailed and a derivation process for the associated uncertainties is exposed. The paper finally analyzes the improvements expected from the refined process.

Destouches, C.; Gregoire, G.; Beretz, D.; Bourganel, S.; Chiron, M.

2009-08-01

178

Influence du chrome et du niobium sur l'équilibre ?-? dans les aluminiures de titane  

NASA Astrophysics Data System (ADS)

L’influence du chrome et du niobium sur les transformations et équilibres de phases des aluminiures de titane dans le domaine biphasé a/g est étudiée par analyse thermique différentielle, dilatomètrie, et métallographie quantitative après traitements thermiques suivis de trempe. Les compositions et les taux de phases à l’équilibre sont déterminés pour différentes températures du domaine biphasé a/g. Les résultats sont comparés aux calculs thermodynamiques réalisés à l’aide d’une banque de données relative aux intermétalliques de base Ti-Al.

Daloz, D.; Hazotte, A.; Lacaze, J.; Charpentier, M.

2004-12-01

179

Preoperative values of CA 15-3 and CEA as prognostic factors in breast cancer: a multivariate analysis.  

PubMed

The role of circulating tumor markers in providing prognostic information has not been widely studied. In the current study, serum levels of the carbohydrate antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) were determined preoperatively in 364 breast cancer patients with no clinical signs of metastasis. The prognostic relevance of these markers for recurrence (175/364) and death of disease (104/175) was determined by Cox multivariate analysis, including the comparison with classical prognostic factors. High levels of both tumor markers were associated with aneuploid tumors with high S-phase fraction and high ornithine decarboxylase activity. CA 15-3 was highly associated with the number of positive lymph nodes and peritumoral lymphatic or blood vessel invasion. No significant associations were found between CEA or CA 15-3 levels and histologic grade, necrosis and steroid receptor status. In univariate analysis, preoperative values, using optimum cutoff values of CA 15-3 (40 U/ml) and CEA (6 ng/ml), were statistically significant for relapse-free survival and overall survival. In multivariate analysis, only node status, DNA ploidy and ornithine decarboxylase activity were independent predictors for relapse-free survival; the estrogen receptor status was a predictor of overall survival. In node-negative patients, ornithine decarboxylase activity was the only factor selected for relapse-free survival. In node-positive patients, the number of lymph nodes and DNA ploidy were the only variables selected for relapse-free survival or overall survival. Estrogen receptor and ornithine decarboxylase activity were excluded for relapse-free survival, but were significant prognostic factors for overall survival. PMID:11553856

Cañizares, F; Sola, J; Pérez, M; Tovar, I; De Las Heras, M; Salinas, J; Peñafiel, R; Martínez, P

180

Differences in plasma gastrin, CEA, and CA 19-9 concentration in patients with proximal and distal colorectal cancer  

Microsoft Academic Search

Summary  \\u000a Aim. We investigated whether there are differences in plasma gastrin, as compared with carcinoembryonic antigen (CEA) and cancer\\u000a antigen (CA) 19-9 between patients with proximal and distal colorectal cancer. Gastrin concentration has also been analyzed,\\u000a dependent on the tumor stage, in order to evaluate the possible prognostic role of this measurement.\\u000a \\u000a \\u000a Methods. In 50 patients with colon cancer-fasting gastrin,

Grzegorz Bombski; Anita Gasiorowska; Daria Orszulak-Michalak; Beata Neneman; Justyna Kotynia; Janusz Strzelczyk; Adam Janiak; Ewa Malecka-Panas

2002-01-01

181

Prognostic and predictive value of CEA and CYFRA 21-1 levels in advanced non-small cell lung cancer patients treated with gefitinib or erlotinib  

PubMed Central

The prognostic and predictive value of pre-treatment serum levels of carcinoembryonic antigen (CEA) and cytokeratin-19 fragments (CYFRA 21-1) were assessed in advanced non-small cell lung cancer (NSCLC) patients treated with gefitinib or erlotinib. Pre-treatment CEA and CYFRA 21-1 levels were measured in 123 advanced NSCLC patients receiving gefitinib or erlotinib. High CEA levels (h-CEA) were significantly associated with females, patients with adenocarcinoma and non-smokers. Low CYFRA 21-1 levels (l-CYFRA 21-1) were significantly associated with a good performance status (ECOG PS 0-1). The overall response rate (RR) was 27.6%, and a higher RR was associated with adenocarcinoma, h-CEA, and epidermal growth factor receptor (EGFR) mutation. Patients with h-CEA had significantly longer progression-free survival (PFS) (P=0.021). Patients with l-CYFRA 21-1 had significantly longer PFS and overall survival (OS) (P=0.006 and P<0.001, respectively). Notably, h-CEA and l-CYFRA 21-1 levels were associated with good prognosis in patients with unknown EGFR mutation status or patients with squamous cell carcinoma (P=0.021 and P=015, respectively). A good ECOG PS (HR=0.45, P=0.017), h-CEA (HR=0.41, P=0.007), l-CYFRA 21-1 (HR=0.52, P=0.025), and an EGFR mutation (HR=0.22, P<0.001) were independently predictive of a longer PFS. A good ECOG PS (HR=0.52, P=0.018), l-CYFRA 21-1 (HR=0.36, P=0.004), and EGFR mutation (HR=0.53, P=0.051) were independently predictive of longer OS. h-CEA and l-CYFRA 21-1 may be prognostic and predictive serum markers for higher response and longer survival in patients with advanced NSCLC receiving gefitinib or erlotinib, particularly in patients with unknown EGFR mutation status or patients with squamous cell carcinoma.

JUNG, MINKYU; KIM, SE HYUN; LEE, YOUNG JOO; HONG, SOOJUNG; KANG, YOUNG AE; KIM, SE KYU; CHANG, JOON; RHA, SUN YOUNG; KIM, JOO HANG; KIM, DAE JOON; CHO, BYOUNG CHUL

2011-01-01

182

Mucinous cystadenoma of the appendix presenting with an elevated carcinoembryonic antigen (CEA): Report of two cases and review of the literature?  

PubMed Central

INTRODUCTION Despite the fact the mucocoele of the appendix is a rare entity it has been the subject of much interest in the literature. The term mucocoele refers to cystic dilatation of the appendix filled with mucin resulting from proximal obstruction of the appendix lumen. PRESENTATION OF CASE We report two patients presenting with mucinous cystadenoma of the appendix with elevation of serum carcinoembryonic antigen (CEA), which has rarely been reported. Both patients had mild symptoms and a normal colonoscopy preoperatively. The diagnosis was not suspected in one patient prior to surgery. The elevated CEA prompted additional diagnostic radiologic investigations including ultrasonography, and computed tomography scans. The patients had uneventful appendicectomies with subsequent normalization of their CEA levels. DISCUSSION Mucinous cystadenoma of the appendix is a rare pathological entity characterized by a dilated mucous filled appendix. The presence of an elevated CEA associated with the presence of this entity is a rare presentation. CONCLUSION Because the diagnosis is rarely suspected prior to surgery patients with an enlarged appendix with associated elevated CEA levels should have careful investigations to exclude malignancy.

McFarlane, M.E.C.; Plummer, J.M.; Bonadie, K.

2013-01-01

183

Anti-carcinoembryonic antigen immunoscintigraphy (technetium-99m-monoclonal antibody BW 431/26) and serum CEA levels in patients with suspected primary and recurrent colorectal carcinoma  

SciTech Connect

This study comprises a total of 141 patients with suspected primary and recurrent colorectal carcinomas, in whom immunoscintigraphy with 99mTc-Mab BW 431/26 was performed. Whole-body scans were done 5.5 hr and SPECT imaging of the abdominal region was done at 6 and 24 hr postinjection of 1100 MBq 99mTc-labeled Mab (1 mg). In the course of primary tumor identification (n = 65), sensitivity of anti-CEA immunoscintigraphy was 95%, specificity 91%. In the diagnosis of early recurrences (n = 76), immunoscintigraphy was the method of choice to clarify the problem (sensitivity 94%; specificity 86%). Overall sensitivity of immunoscintigraphy in patients with suspected colorectal carcinomas and early recurrences was 95%, specificity 88%. Human anti-mouse antibodies were found in 29% (80% predominantly anti-isotypic, 20% predominantly anti-idiotypic). In contrast to anti-CEA immunoscintigraphy, the results of serum CEA levels were rather disappointing. Only 18 out of the 43 surgically verified primary colorectal carcinomas and 17 out of 32 patients with recurrences showed elevated serum CEA levels. In our clinical experience with this 99mTc-labeled anti-CEA antibody, immunoscintigraphy can play an important role in the identification of early colorectal recurrences and in postoperative colorectal cancer patients it should be performed in cases with unclear transmission computed tomography.

Lind, P.; Lechner, P.; Arian-Schad, K.; Klimpfinger, M.; Cesnik, H.; Kammerhuber, F.; Eber, O. (Internal Department/Nuclear Medicine, Barmherzige Brueder Eggenberg Hospital, Graz (Austria))

1991-07-01

184

Considérations à proposdes caractères mycologiques et pathogéniques du Keratinomyces ajelloi — Vanbreuseghem 1952, saprophyte du sol  

Microsoft Academic Search

Résumé Les auteurs ont signalé, pour la première fois en Roumanie (à Bucarest), la présence dans les couches superficielles du sol duKeratinomyces ajelloi —Vanbreuseghem 1952. La morphologie microscopique de l'une des deux souches, étudiées de ce point de vue, était un peu plus riche que celle de la souche isolée, pour la première fois parVanbreuseghem car, outre les macroconidies, on

R. Evolceanu; I. Altera?

1959-01-01

185

Genèse du paysage linguistique, pratiques et représentations à la marge sud du territoire français  

Microsoft Academic Search

Les Pyrénées méditerranéennes ont constitué de longue date l'enjeu de conflits d'intéerêts entre mouvances venues du Nord (empire Franc, Royaume et République française) et mouvances méridionales (mouvance arabo-musulmane, mouvance aragonaise et castillane etc.). Au bout du processus, les départements français de l'Aude et des Pyrénées-Orientales, écartelés entre ces deux mouvances, ont pour caractéristique de constituer une zone de contact entre

Francis Manzano

2008-01-01

186

Tumour-associated trypsin inhibitor (TATI) in human ovarian cyst fluid. Comparison with CA 125 and CEA.  

PubMed Central

The levels of tumour-associated trypsin inhibitor (TATI), CA 125 and CEA were measured in ovarian cyst fluids from 21 patients. TATI in cyst fluid was immunologically and physicochemically similar to the peptide originally isolated from the urine of a patient with ovarian cancer. Mucinous cysts contained significantly higher levels of TATI than did serous cysts. Immunohistochemically TATI was localized in the apical parts of cells of mucinous ovarian cysts. These results suggest that this tumour-associated peptide is actually produced by a tumour. Like TATI, CEA occurred at higher concentrations in mucinous than in serous cyst fluids, whereas CA 125 was found in higher concentrations in serous than in mucinous cyst fluids. The concentrations of these tumours markers in cyst fluids did not correlate with circulating levels of the same markers. In spite of the very high levels of all these tumour markers in benign cyst fluids, serum levels were normal or only slightly elevated. Clearly elevated serum levels occurred only in patients with malignant tumours. Cyst fluid levels of these tumour markers could not be used to distinguish between benign and malignant tumours. Images Figure 4

Halila, H.; Huhtala, M. L.; Haglund, C.; Nordling, S.; Stenman, U. H.

1987-01-01

187

Sign communication in Cri du chat syndrome  

Microsoft Academic Search

This paper presents findings from a study on the use of sign supported Norwegian (SSN) in two individuals with Cri du chat syndrome (CCS). The study gives a first account of some selected aspects of production and intelligibility of SSN in CCS. Possible deviance in manual parameters, in particular inter- and\\/or intra-subject variation in the use of handshape is investigated.

Sonja Erlenkamp; Kristian Emil Kristoffersen

2010-01-01

188

Growth study of cri du chat syndrome  

Microsoft Academic Search

We compared the growth of children with cri du chat (5p?) syndrome with the 1990 UK growth curves. Most subjects had impaired growth, particularly of head circumference. The more emaciated the child the more pronounced the microcephaly, showing the need for growth and nutrition monitoring.

M S R Collins; J Eaton-Evans

2001-01-01

189

Prairie du Chien: A Historical Study.  

National Technical Information Service (NTIS)

A literature and record search for locations of prehistoric and historic sites in the Prairie du Chien area was undertaken by the Wisconsin State Historical Society. A search was made to assess the cultural resources present on St. Friole Island and the a...

E. S. Oerichbauer J. E. Freeman

1976-01-01

190

Analyse des mécanismes de détermination du chômage  

Microsoft Academic Search

[fre] Depuis 1965, la France, comme les pays membres de l'OCDE, est confrontée à une progression du chômage. Cette montée plus ou moins lente et régulière comporte des accélérations conjoncturelles suivies de pauses, voire de replis. Parallèlement les créations d'emplois semblent moins à même que par le passé de résorber le chômage. Comprendre ce mouvement implique de prendre en considération

Robert Salais

1977-01-01

191

Rick and Becky DuFour  

ERIC Educational Resources Information Center

In 1969, a concern with the deep inequity of students' experiences and opportunities in traditional school systems first drove social studies teacher Rick DuFour to begin advocating for the kind of reforms that would jell into his transformative model, Professional Learning Communities (PLC) at Work, some 16 years later. The core belief of the PLC…

McLester, Susan

2012-01-01

192

Les politiques monétaires au sein du SME  

Microsoft Academic Search

[fre] Les politiques monétaires au sein du SME, . par Patrick Jacq, Eric Jondeau, Frank Sédillot. . . Les contraintes imposées par le SME et les perspectives de l 'union européenne ont permis une convergence spectaculaire des taux d'intérêt de l'ensemble des pays membres. Cette convergence a été en grande partie asymétrique, l'Allemagne jouant pour la plupart des pays le

Frank Sédillot; Eric Jondeau; Patrick Jacq

1993-01-01

193

[The value of marker antigens TPS, SCC and CEA in diagnosis, evaluation of histologic type and clinical disease progression in patients with cervical carcinoma].  

PubMed

Pretreatment values TPS, SCC and CEA were measured in 84 patients with cervical carcinoma in order to evaluate the usefulness of markers in diagnosis, estimation of the histological type, estimation of stage of disease and grade of cellular differentiation. TPS was raised in 78.4%, SCC was raised in 71.8% and CEA was raised in 32.4% patients with cervical carcinoma. The frequency of increased results and absolute value of TPS and SCC levels showed tendency to significant increase with the stage of disease and to the grade of cellular differentiation. The highest sensitivities TPS and SCC were observed in patients with carcinoma planoepitheliale macrocellulare akeratodes, CEA in adenocarcinoma clarocellulare. These results suggest that TPS especially in the combination with SCC may be useful in the diagnosis and estimation of stage of disease of patients with cervical carcinoma. PMID:11320545

Zakrzewska, I

2001-01-01

194

Human Evolution  

NSDL National Science Digital Library

This resource from Bruce MacEvoy links to documents "summarizing the hominid fossil record and hypothesized lines of human evolution from 5 million years ago to the present." The site is divided into five parts: Chart of Human Evolution, Tour of the Human Fossil Record, The Hominid Brain, Hominid Tools, Hominid Fossil Sites and Patterns of Hominid Dispersal.

Macevoy, Bruce

1969-12-31

195

Evolution Lessons  

NSDL National Science Digital Library

This collection of lessons from the Evolution and the Nature of Science Institute (ENSI) focus on evolution. Each title is an active link to the named activity. The site also contains links to synopses for all of the lessons and a statement on the appropriate grade level for the lessons.

196

Elevated levels of serum tumor markers CA 15-3 and CEA are prognostic factors for diagnosis of metastatic breast cancers.  

PubMed

To investigate the prognostic value of tumor markers, cancer antigen 15-3 (CA 15-3) and carcinoembryonic antigen (CEA) levels at diagnosis of systemic recurrence. After primary treatments of locoregional breast cancers, serum CA 15-3 and/or CEA concentrations were regularly measured, and systemic recurrences were identified in 351 patients between January 1999 and December 2009. The association between tumor marker levels at systemic recurrence and survival were investigated by univariate and multivariate analyses. Elevated CA 15-3 and CEA levels were identified in 194 of 349 (55.6 %) and 111 of 308 (36.0 %) patients, respectively, at diagnosis of systemic recurrence. Elevated levels of CA 15-3 and CEA were correlated with visceral or multiple recurrences and elevated preoperative levels. Elevation of CA 15-3 was more prominent in younger patients and in primary node-positive tumors, while CEA was elevated in older patients at diagnosis and in estrogen receptor (ER)-positive tumors. Elevated tumor markers as well as ER negativity, short disease-free interval, and advanced stage at initial diagnosis showed independent prognostic significance on multivariate analysis. Among 306 patients for whom levels of both tumor markers at recurrence were available, 106 patients without elevation of either marker showed significantly better overall survival than those with elevated levels of either one or both markers, and the significance persisted in multivariate analysis. Elevated serum CA 15-3 and CEA levels at recurrence suggest increased tumor burden and may be prognostic for survival for metastatic breast cancer patients. PMID:24072270

Lee, Jun Sang; Park, Seho; Park, Ji Min; Cho, Jung Hoon; Kim, Seung Il; Park, Byeong-Woo

2013-09-27

197

Non-radioactive hybridization in microwells using enzyme linked immune sorbent assay for detection of RT-PCR-Am-plified CK19- and CEA-mRNA  

Microsoft Academic Search

Summary  PCR enzyme linked immune sorbent assay (ELISA) was developed for detection of RT-PCR-amplified cytokeratin 19 (CK19) mRNA\\u000a and carcinoembryonic antigen (CEA) mRNA. The non-radioactive hybridization was performed in a streptavidin-coated microwell\\u000a with digoxigenin-labeled PCR products and with biotin-labeled capture probe. PCR ELISA was proved to be expedient, simple,\\u000a sensitive and safe for identification of CK19-, CEA-RT-PCR products. These results were

Zhong Xiaoyan; Sepp Raul; Astrid Eichler; Gunther Bastert

1999-01-01

198

Structure crustale et anomalies du champ de gravite dans l'est du Canada  

NASA Astrophysics Data System (ADS)

Cette these presente les resultats d'etudes gravimetriques menees dans le Bouclier canadien. Les mesures du champ de gravite recoltees le long et a proximite de divers transects Lithoprobe y sont interpretees. Chacun des chapitres de cette these est un article publie ou soumis. Le premier article presente l'interpretation gravimetrique le long de la ligne sismique 52 de Lithoprobe, dans la province de Grenville. A l'echelle regionale, la modelisation de l'anomalie de Bouguer invoque un amincissement crustal au sud du front de Grenville sous le terrane allochtone du reservoir Cabonga. Cet amincissement, localise au niveau de la croute inferieure, peut etre associe a une extension post-orogenique. Le modele gravimetrique a aussi permis de mettre en evidence des caracteristiques majeures non revelees par les donnees sismiques, telle que la zone de contact subverticale entre les terranes du reservoir de Cabonga et du reservoir Dozois. La rampe de Baskatong representerait une discontinuite majeure le long de laquelle, les terranes proterozoiques furent accretes. Par ailleurs, un modele de l'anomalie residuelle, dans la partie nord du profil, met en evidence trois corps gabbroiques peu profonds. Le second article presente des modeles crustaux du nord de la province du Superieur a la lumiere de nouvelles donnees de gravite recoltees le long d'un transect traversant les sous-provinces de Nemiscau et La Grande. L'interpretation de l'anomalie de Bouguer pour le nord de l'Abitibi et l'Opatica, invoque un epaississement crustal. Pour les sous-provinces de Nemiscau et La Grande, l'interpretation gravimetrique invoque une densite de la croute superieure plus elevee qu'en Abitibi et en Opatica. Un leger epaississement crustal est observe dans la sous-province de La Grande. Des sequences supracrustales mafiques sont aussi mises en evidence a l'extremite nord du profil dans la sous-province de La Grande. La signature gravimetrique associee a la variation laterale de densite et les evidences de terrain indiquent un pendage vers le nord des principales frontieres tectoniques. Le troisieme chapitre fait l'objet d'une etude du champ de pesanteur au dessus de la region de la baie d'Ungava a partir de donnees satellite et de nouvelles donnees recoltees le long de la cote sud de la baie. Un leve gravimetrique partant de la baie aux Feuilles, dans la province du Superieur, traversant l'Orogene du Nouveau Quebec (ONQ), et finissant pres de la riviere George dans le craton de Rae, a ete realise. L'interpretation des donnees acquises a permis de fournir des modeles de densite. Ces modeles mettent en evidence un epaississement crustal sous l'ONQ et un amincissement sous le terrane de Kuujjuaq, a l'est de l'orogene. Alors que plus a l'est, dans le craton de Rae, une anomalie negative de quelques dix milligals est correlee avec les extensions vers le nord de la zone de cisaillement de la riviere George (ZCRG) et du batholite de De Pas. L'orientation des structures sur les modeles de gravite suggere un chevauchement du craton de Rae au dessus de l'ONQ. (Abstract shortened by UMI.)

Telmat, Hamid

199

Cultural evolution, the Baldwin effect, and social norms  

Microsoft Academic Search

Cultural evolution, the Baldwin effect, and social norms\\u000a \\u000a Jean Lachapelle12 , Luc Faucher13 and Pierre Poirier13\\u000a \\u000a \\u000a \\u000a (12) \\u000a Department of Humanities and Liberal Arts, Champlain Regional College, Université du Québec á Montréal, Québec, Canada\\u000a \\u000a \\u000a \\u000a \\u000a \\u000a \\u000a (13) \\u000a Université du Québec á Montréal, Québec, Canada\\u000a \\u000a \\u000a Abstract\\u000a The goal of this paper is to analyze the role of the Baldwin effect in cultural evolution and to propose that it

Jean Lachapelle; Luc Faucher; Pierre Poirier

200

Fiscalité et coût d'usage du capital : incidences sur l'investissement, l'activité et l'emploi  

Microsoft Academic Search

[fre] Une mesure du coût du capital sur données individuelles d’entreprises qui distingue le coût du financement par fonds propres du coût de financement par endettement montre que la dispersion du coût d’usage du capital est relativement élevée. Cette dispersion s’explique, d’une part, par la forte hétérogénéité des structures de financement et, d’autre part, par la variabilité du coût du

Bruno Crépon; Christian Gianella

2001-01-01

201

Application of the New Decommissioning Regulation to the Nuclear Licensed Facilities (NLF) at Fontenay-aux-Roses's Nuclear Center (CEA)  

SciTech Connect

This abstract describes the application of the new decommissioning regulation on all Nuclear Licensed Facilities (NLF is to say INB in French) at Fontenay-aux-Roses's Center (CEA/FAR). The decommissioning process has been applied in six buildings which are out of the new nuclear perimeter proposed (buildings no 7, no 40, no 94, no 39, no 52/1 and no 32) and three buildings have been reorganized (no 54, no 91 and no 53 instead of no 40 and no 94) in order to increase the space for temporary nuclear waste disposal and to reduce the internal transports of nuclear waste on the site. The advantages are the safety and radioprotection improvements and a lower operating cost. A global safety file was written in 2002 and 2003 and was sent to the French Nuclear Authority on November 2003. The list of documents required is given in the paragraph I of this paper. The main goals were two ministerial decrees (one decree for each NLF) getting the authorization to modify the NLF perimeter and to carry out cleaning and dismantling activities leading to the whole decommissioning of all NLF. Some specific authorizations were necessary to carry out the dismantling program during the decommissioning procedure. They were delivered by the French Nuclear Safety Authority (FNSA) or with limited delegation by the General Executive Director (GED) on the CEA Fontenay-aux-Roses's Center, called internal authorization. Some partial dismantling or decontamination examples are given below: - evaporator for the radioactive liquid waste treatment station (building no 53): FNSA authorization: phase realised in 2002/2003. - disposal tanks for the radioactive liquid waste treatment station (building no 53) FNSA authorization: phase realised in 2004, - incinerator for the radioactive solid waste treatment station (building no 07): FNSA authorization: operation realised in 2004, - research equipments in the building no. 54 and building no. 91: internal authorization ; realised in 2005, - sample-taking to characterize solvent contained in one tank of Petrus installation (NLF 57, building 18) for radiological and chemical analysis needed to prepare the treatment and the evacuation of these wastes : internal authorization ; realised in june 2005. It was possible to plan the whole decommissioning process on the Nuclear Licensed Facilities of Fontenay-aux-Roses's Center (CEA/FAR) taking into account the French new regulation and to plan a coherent and continue program activity for the dismantling process. For the program not to be interrupted during the administrative process (2003-2006), specific authorisations have been delivered by the French Nuclear Safety Authority or by the General Executive Director (GED) on the CEA Fontenay-aux- Roses's Center (internal authorization). The time schedule to complete the entire program is until 2017 for NLF 'Procede' (NLF no 165) and until 2018 for NLF 'Support' (NLF no 166). Since 1999, an annual press meeting has been organised by the Fontenay-aux-Roses's Center Head Executive Manager.

Sauret, Josiane [Commissariat a l'Energie Atomique, Direction du Centre de Fontenay-aux-Roses, Cellule de Surete nucleaire, de controle des Matieres, de controle des Transports et de la Qualite, 18 route du Panorama BP 6 - 92265 Fontenay-aux-Roses Cedex (France); Piketty, Laurence; Jeanjacques, Michel [Commissariat a l'Energie Atomique, Direction de l'Energie Nucleaire, Direction deleguee des Activites Nucleaires de Saclay, Departement des Reacteurs et des Services Nucleaires, service d'Assainissement de Fontenay-aux-Roses, 18 route du Panorama BP 6 - 92265 Fontenay-aux-Roses Cedex (France)

2008-01-15

202

Flux de travailleurs au cours du cycle conjoncturel  

Microsoft Academic Search

Cette étude analyse la dynamique des flux de travailleurs au cours du cycle conjoncturel à partir de deux types de données : l'enquête Emploi de l'Insee et les listes de demandeurs d'emploi inscrits à Pôle emploi. Des transitions mensuelles sur le marché du travail sont ainsi construites pour ces deux types de données. Les contributions du taux de perte et

Yves Dubois; Jean-Olivier Hairault; Thomas Le Barbanchon; Thepthida Sopraseuth

2011-01-01

203

Les différences de carrières salariales à partir du premier emploi  

Microsoft Academic Search

[fre] Les trajectoires salariales dans le secteur privé se différencient dès le premier emploi durable. Les salariés ont, en effet, des débuts de carrière très différents, soit parce qu’ils reflètent certaines caractéristiques qui leur sont propres et sur lesquelles on ne dispose pas d’informations, soit du fait du hasard et de la date d’insertion sur le marché du travail, parce

Sylvie Le Minez; Sébastien Roux

2002-01-01

204

Quelle stratégie chirurgicale dans les cancers du rein localement avancés?  

Microsoft Academic Search

Le cancer du rein localement avancé regroupe ?ensemble des cancers qui sont ni localisés intracapsulaires (pTl, pT2), ni métastatiques\\u000a (M+). Le traitement de référence du cancer du rein est la chirurgie. Le but sera donc de proposer ?exérèse la plus large possible\\u000a afin de retirer ?ensemble de la masse tumorale, aucun traitement complémentaire n'étant à ce jour actif sur les

Hervé Lang; Didier Jacqmin; Catherine Roy; Frédéric Fernandez; Bernard Wagner; Pascal Mouracadé

205

Comparison of anti-fetal colonic microvillus and anti-CEA antibodies in peroperative radioimmunolocalisation of colorectal cancer.  

PubMed Central

Local recurrence of colorectal cancer may result from failure to assess accurately the extent of tumour at operation. It has been suggested that peroperative radioimmunolocalisation may improve this assessment. The degree to which this is possible has been studied using a hand-held gamma detecting probe and comparing two 125I-labelled monoclonal antibodies to colorectal tumours. The antibodies were to fetal colonic microvillus membrane (FM1D10) and to carcinoembryonic antigen (A5B7). Sixty-nine per cent (9/13) of the FM1D10 and 98% (43/44) of A5B7 labelled tumours took up significant amounts of antibody with a tumour to normal colon ratio of more than 1.5:1. The uptake was significantly better for A5B7 with a median tumour to normal colon ratio of 3.3 (1.1-13.8) compared to 1.85 (0.75-7.7) for FM1D10 (P less than 0.001). The tumour: colon ratio of both antibodies was independent of the serum CEA, Dukes' stage or the degree of histological differentiation. There was a linear correlation for tumour to normal colon ratios between the gamma detecting probe and the same tissue examined in a conventional well counter (correlation coefficient r = 0.78, P less than 0.001). Colorectal tumours demonstrate a rapid and reliable uptake of anti-CEA monoclonal antibody A5B7. This antibody can be detected with a peroperative gamma detecting probe and has the potential to improve the surgeon's appreciation of the extent of tumour and therefore may influence the surgery performed. Detailed clinical studies are now being carried out.

Blair, S. D.; Theodorou, N. A.; Begent, R. H.; Dawson, P. M.; Salmon, M.; Riggs, S.; Kelly, A.; Boxer, G.; Southall, P.; Gregory, P.

1990-01-01

206

DU-AGG pilot plant design study  

SciTech Connect

The Idaho National Engineering Laboratory (INEL) is developing new methods to produce high-density aggregate (artificial rock) primarily consisting of depleted uranium oxide. The objective is to develop a low-cost method whereby uranium oxide powder (UO[sub 2], U[sub 3]O[sub ]8, or UO[sub 3]) can be processed to produce high-density aggregate pieces (DU-AGG) having physical properties suitable for disposal in low-level radioactive disposal facilities or for use as a component of high-density concrete used as shielding for radioactive materials. A commercial company, G-M Systems, conducted a design study for a manufacturing pilot plant to process DU-AGG. The results of that study are included and summarized in this report. Also explained are design considerations, equipment capacities, the equipment list, system operation, layout of equipment in the plant, cost estimates, and the proposed plan and schedule.

Lessing, P.A.; Gillman, H.

1996-07-01

207

The clinical validity of circulating tumor-associated antigens CEA and CA 19-9 in primary diagnosis and follow-up of patients with gastrointestinal malignancies  

Microsoft Academic Search

Summary The clinical validity of monitoring the tumor markers carcinoembryonic antigen (CEA) and CA 19-9 were investigated in 602 patients with colorectal, gastric, and pancreatic carcinomas. Sensitivity and specificity of the tests were evaluated preoperatively as well as in the postoperative follow-up for early detection of disease progression and recurrence. At a 95% level of specificity as calculated from a

H. J. Staab; T. Brümmendorf; A. Hornung; F. A. Anderer; G. Kieninger

1985-01-01

208

Pourfour Du Petit syndrome after interscalene block  

PubMed Central

Interscalene block is commonly associated with reversible ipsilateral phrenic nerve block, recurrent laryngeal nerve block, and cervical sympathetic plexus block, presenting as Horner's syndrome. We report a very rare Pourfour Du Petit syndrome which has a clinical presentation opposite to that of Horner's syndrome in a 24-year-old male who was given interscalene block for open reduction and internal fixation of fracture upper third shaft of left humerus.

Santhosh, Mysore Chandramouli Basappji; Pai, Rohini B.; Rao, Raghavendra P.

2013-01-01

209

Traitement endoscopique du cancer colorectal précoce  

Microsoft Academic Search

Résumé  Le présent article décrit le traitement endoscopique du cancer colorectal précoce. La polypectomie endoscopique a été réalisée\\u000a en utilisant trois techniques: la pince chaude, la polypectomie conventionnelle à l’anse diathermique et la résection muqueuse.\\u000a Les cancers colorectaux précoces de type saillant ont été réséqués par la polypectomie conventionnelle à l’anse diathermique\\u000a et les cancers de type superficiel par la technique

M. Igarashi; K. Kobayashi; T. Katsumata; K. Saigenji

1998-01-01

210

LES ACTIVITES DU LARYNX EN BERBERE  

Microsoft Academic Search

Ce présent travail traite des ajustements glottaux et supraglottaux pendant la production des obstruentes sourdes simples et géminées berbères en utilisant la méthode de la photoélectroglottographie (transillumination) combinée avec la fibroscopie. L'objet de l'étude concerne plus particulièrement les obstruentes intervocaliques et examine l'effet de la gémination sur la durée acoustique (durées de l'occlusion et du VOT pour les occlusives), la

RACHID RIDOUANE

2008-01-01

211

Proprietes de Transport Electronique DU Rutile Stoechiometrique  

NASA Astrophysics Data System (ADS)

Le rutile est un oxyde metallique qui presente beaucoup de similitudes avec certains perovskites notamment le titanate de barium ou de strontium. Il est comme ces derniers, compose d'un agencement d'octaedres d'oxygene centres sur l'atome de titane. Ces octaedres sont responsables de la forte polarisabilite de ces cristaux et de leur grande constante dielectrique. Leurs proprietes optiques, seuil d'absorption et spectre de phonons, sont par exemple forts semblables. La presente etude vise a determiner la nature du transport electronique dans le rutile stoechiometrique pur et d'en comparer les resultats avec les proprietes de certains perovskites. Nous determinerons par differentes mesures optoelectroniques les parametres caracteristiques des pieges et leur influence sur le transport des electrons et des trous. Les resultats de conductivite et de capacitance de meme que les spectres de photoconductivite dans nos echantillons ont mis en evidence la presence d'au moins cinq niveaux energetiques dans la bande interdite du rutile agissant comme pieges pour les electrons ou pour les trous et qui jouent un role de premiere importance dans le comportement electrique du rutile. Par la technique de charge transitoire, nous determinerons pour la premiere fois dans le rutile stoechiometrique la grandeur de la mobilite de derive des trous a la temperature ambiante soit 3,4 cm^2/V cdots et nous etablierons une borne superieure a la mobilite des electrons soit 0,1 cm^2 /Vcdots.

Keroack, Danielle

212

La Relation Voix-Sieges et les Sources du Paradoxe du Referendum : Cas des Elections Cantonales Francaises  

Microsoft Academic Search

Cet articleetudie les sources du paradoxe du referendum. Celles-ci ne sont que les biais resultant du transfert des voix en sieges. Ces biais se resument principalement dans les trois facteurs suivants: le gerrymandering, le malap- portionment et le taux de participation auxquels s'ajoutent parfois la question de l'influence d'un tiers parti (victorieux ou non). En employant les donnees deselections cantonales

Rahhal Lahrach; Vincent Merlin

2008-01-01

213

Diagnostic value of CEA, CA 15-3, CA 19-9, CYFRA 21-1, NSE and TSA assay in pleural effusions.  

PubMed

The aim of this study was to evaluate the individual and combined diagnostic utility of six tumor markers in patients with pleural effusion. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), cytokeratin fragment 19 (CYFRA 21-1), neuron-specific enolase (NSE) and total sialic acid (TSA) were assayed in 74 patients with pleural effusions (44 malignant and 30 benign). All tumor markers except TSA and NSE were increased in both serum and pleural fluid of patients with malignant diseases. Using the cut-off values 3 ng/ml, 14 U/ml, 5 U/ml, 8 ng/ml and 70 mg/dl for pleural fluid CEA, CA 15-3, CA 19-9, CYFRA 21-1 and TSA, respectively, the sensitivity (%) and specificity (%) of these tumor markers were as follows: CEA; 52/77, CA 15-3; 80/93, CA 19-9; 36/83, CYFRA 21-1; 91/90, TSA; 80/67, for differentiating malignant effusions from benign. When CA 15-3 and CYFRA 21-1 combined, the sensitivity and specificity were increased (100 and 83%, respectively). Classifying the malignant effusions as bronchial carcinoma and malignant pleural mesothelioma, CEA was shown to have the highest sensitivity and specificity (88 and 90%, respectively) while the combination of CEA with other tumor markers increased sensitivity but decreased specificity. According to our results, tumor markers are not suitable for the differential diagnosis of malignancy. PMID:11162861

Alata?, F; Alata?, O; Metinta?, M; Colak, O; Harmanci, E; Demir, S

2001-01-01

214

Combined use of AFP, CEA, CA125 and CAl9-9 improves the sensitivity for the diagnosis of gastric cancer  

PubMed Central

Background The detection of serum tumor marker becomes a common method for screening tumors. However, this method has not been widely used for routine gastric cancer screening. In this study we aimed to determine whether the combined use of tumor markers may increase the sensitivity for the diagnosis of gastric cancer. Methods Serum AFP, CEA, CA125 and CA19-9 levels were measured in 149 patients with gastric cancer, 111 patients with benign gastric diseases and 124 healthy people, who visited the First Affiliated Hospital of Nanchang University from May 2011 to May 2012. Statistical analysis including receiver operating characteristic (ROC) curve, the area under the curve (AUC), and logistic regression analysis was performed to evaluate the diagnostic value of these markers on gastric cancer. Results Serum levels of CEA, CA125, and CA19-9 in gastric cancer group were higher than that in the benign gastric disease group and the healthy control group (P <0.005). The sensitivity of AFP, CEA, CA125 and CA19-9 in the diagnosis of gastric cancer was 4.7-20.8% individually, and increased to 40.3% in combination. By using optimal cut-off value, the sensitivity of CEA, CA125, and CA19-9 for the diagnosis of gastric cancer was improved. Especially, the sensitivity of CEA increased to 58.4% and the sensitivity of combined use of four markers increased to 69.1%. The age and gender had no effects on the diagnostic value of these markers. Conclusions The determination and application of optimal cut-off values based on ROC curve and logistic regression analysis could improve the diagnosis of gastric cancer based on common tumor markers.

2013-01-01

215

Deficits in Substance P mRNA Levels in the CeA are Inversely Associated with Alcohol-Motivated Responding  

PubMed Central

In the present study, in vitro and in vivo studies were conducted to determine the relationship between innate substance P [SP] levels and alcohol-motivated behavior in alcohol-preferring [P] and nonpreferring [NP] rat lines. In experiment 1, in situ hybridization and quantitative autoradiography were used to detect and measure SP mRNA levels in discrete brain loci of the P and NP rats. The results indicated significantly lower SP mRNA levels in the central nucleus of the amygdala [CeA] of P compared with NP rats. Experiment 2 evaluated the effects of SP, microinfused into the CeA, on alcohol [10% v/v] and sucrose [2% w/v] motivated responding in the P rat. The results revealed that, when infused into the CeA [1 – 8 µg], SP reduced alcohol responding by 48 – 85% of control levels, with no effects on sucrose responding. Neuroanatomical control infusions [1 – 8 µg] into the caudate putamen [CPu] also failed to significantly alter alcohol or sucrose-motivated behaviors. Given the selective reductions on alcohol [compared to sucrose] responding by direct intracranial infusion of SP, the data suggest that deficits in SP signaling within the CeA [an anxiety regulating locus] are inversely associated with alcohol-motivated behaviors. Activation of SP receptors in the CeA may reduce anxiety-like behavior in the P rat and contribute to reductions on alcohol responding. The SP system may be a suitable target for the development of drugs to reduce alcohol-drinking behavior in humans.

June, Harry L.; Yang, Andrew Rong Song Tzeng; Yi, Heon Soo; Gu, Zhu-hua; Lumeng, Lawrence; Hwang, Bang H.

2009-01-01

216

Developmental and behavioural characteristics of cri du chat syndrome  

Microsoft Academic Search

Developmental and behavioural characteristics were assessed in 27 children with cri du chat syndrome using the Society for the Study of Behavioural Phenotypes questionnaire, which gave information on prenatal and perinatal conditions, neurological problems, and developmental and behavioural difficulties. The findings suggest that the behavioural profile of children with cri du chat syndrome incorporates self injurious behaviour, repetitive movements, hypersensitivity

K M Cornish; J Pigram

1996-01-01

217

The biokinetics of uranium migrating from embedded DU fragments  

Microsoft Academic Search

Military uses of depleted uranium (DU) munitions have resulted in casualties with embedded DU fragments. Assessment of radiological or chemical health risks from these fragments requires a model relating urinary U to the rate of migration of U from the fragments, and its accumulation in systemic tissues. A detailed biokinetic model for U has been published by the International Commission

R. W Leggett; T. C Pellmar

2003-01-01

218

Oxidation states of uranium in DU particles from Kosovo  

Microsoft Academic Search

The oxidation states of uranium contained in depleted uranium (DU) particles were determined by synchrotron radiation based ?-XANES, applied to individual particles in soil samples collected at Ceja Mountain, Kosovo. Based on scanning electron microscopy (SEM) with XRMA prior to ?-XANES, DU particles ranging from submicrons to about 30 ?m (average size: 2 ?m or less) were identified. Compared to

B. Salbu; K. Janssens; O. C. Lind; K. Proost; P. R. Danesi

2003-01-01

219

Les entreprises françaises à l'heure du brevet européen  

Microsoft Academic Search

[fre] Les entreprises françaises à l'heure du brevet européen . Depuis son entrée en vigueur en 1 978, le brevet européen a connu une croissance régulière auprès des déposants français, passant de près de 2 000 demandes en 1 979 à un peu plus du double dix ans plus tard. Les déposants sont, dans une grande mesure, des personnes morales,

Jean-Christophe Bussy; Isabelle Kabla; Catherine Carpentier

1994-01-01

220

Persistance du chômage, répartition des revenus et qualifications  

Microsoft Academic Search

[fre] Persistance du chômage, répartition des revenus et qualifications . Depuis le milieu des années soixante-dix, le taux de chômage a augmenté, en France comme en Europe, de près de 10 points. Aux États-Unis, le taux est le même en 1995 que vingt ans auparavant. Les deux explications les plus pertinentes à la persistance du chômage européen et à la

Henri Sneessens

1995-01-01

221

Environnement, écologie: Bases écologiques à un plan du paysage du Jura bernois, Suisse  

Microsoft Academic Search

[fre] Un plan directeur a été établi sur la base de 3 cartes écologiques : pollution potentielle de l'eau, fonctions prioritaires des forêts, vocation naturelle des aires agricoles. Ces informations permettent d'organiser les activités humaines sans nuire aux conditions naturelles du milieu. Le plan a déjà fourni des critères pour des options politiques de développement. [eng] The ecological bases of

Bernard Lieberherr

1977-01-01

222

SINDROM CRI DU CHAT - PRIKAZ PRIMERA CRI DU CHAT SYNDROME - CASE REPORT  

Microsoft Academic Search

Background. The article describes a patient with clinical features of the Cri du chat syndrome. The syndrome is relatively rare chromosomal disorder caused by a deletion of the tip of the short arm of chromosome 5. Cry that sounds like the meowing of a cat, typical facial dysmorphism, primordial growth deficiency and severe psychomotor retardation with microcephaly and hypotonia are

Lilijana Besednjak-Kocijan?i?; Mirjam Stopar-Obreza; Darja Paro-Panjan

223

Inversion of infrared spectra obtained at the 'Observatoire du Pic du Midi'  

Microsoft Academic Search

The techniques used and data gathered with interferometry and heterodyne spectrometers at the Pic du Midi Observatory during several years of measurements of minor atmospheric constituents are reported. The data were gathered in 1980-82. Absorption and emission were assayed at sunrise, sunset, smaller zenith angles and in full moon conditions. The survey concentrated on nitric acid and chlorofluorocarbon (freon) 11

C. Lippens; C. Muller

1983-01-01

224

Cepheid evolution  

SciTech Connect

A review of the phases of stellar evolution relevant to Cepheid variables of both Types I and II is presented. Type I Cepheids arise as a result of normal post-main sequence evolutionary behavior of many stars in the intermediate to massive range of stellar masses. In contrast, Type II Cepheids generally originate from low-mass stars of low metalicity which are undergoing post core helium-burning evolution. Despite great progress in the past two decades, uncertainties still remain in such areas as how to best model convective overshoot, semiconvection, stellar atmospheres, rotation, and binary evolution as well as uncertainties in important physical parameters such as the nuclear reaction rates, opacity, and mass loss rates. The potential effect of these uncertainties on stellar evolution models is discussed. Finally, comparisons between theoretical predictions and observations of Cepheid variables are presented for a number of cases. The results of these comparisons show both areas of agreement and disagreement with the latter result providing incentive for further research.

Becker, S.A.

1984-05-01

225

Accepting evolution.  

PubMed

Poor public perceptions and understanding of evolution are not unique to the developed and more industrialized nations of the world. International resistance to the science of evolutionary biology appears to be driven by both proponents of intelligent design and perceived incompatibilities between evolution and a diversity of religious faiths. We assessed the success of a first-year evolution course at the University of Cape Town and discovered no statistically significant change in the views of students before the evolution course and thereafter, for questions that challenged religious ideologies about creation, biodiversity, and intelligent design. Given that students only appreciably changed their views when presented with "facts," we suggest that teaching approaches that focus on providing examples of experimental evolutionary studies, and a strong emphasis on the scientific method of inquiry, are likely to achieve greater success. This study also reiterates the importance of engaging with students' prior conceptions, and makes suggestions for improving an understanding and appreciation of evolutionary biology in countries such as South Africa with an inadequate secondary science education system, and a dire lack of public engagement with issues in science. PMID:18067569

Chinsamy, Anusuya; Plagányi, Eva

2007-12-06

226

Cepheid Evolution.  

National Technical Information Service (NTIS)

A review of the phases of stellar evolution relevant to Cepheid variables of both Types I and II is presented. Type I Cepheids arise as a result of normal post-main sequence evolutionary behavior of many stars in the intermediate to massive range of stell...

S. A. Becker

1984-01-01

227

Security Evolution.  

ERIC Educational Resources Information Center

|Examines how to evaluate school security, begin making schools safe, secure schools without turning them into fortresses, and secure schools easily and affordably; the evolution of security systems into information technology systems; using schools' high-speed network lines; how one specific security system was developed; pros and cons of the…

De Patta, Joe

2003-01-01

228

Le kyste hydatique du cordon spermatique: une localisation exceptionnelle  

PubMed Central

L’ hydatidose est une anthropo-zoonose due au développement chez l'homme de la forme larvaire du taenia Echinococcus granulosis. La plupart des kystes hydatiques se localisent dans le foie et les poumons. Le kyste hydatique du cordon spermatique est extrêmement rare avec seulement 4 cas rapportés dans la littérature. Les auteurs rapportent dans cet article un nouveau cas d'hydatidose du cordon spermatique. Il s'agissait d'un homme de 40 ans qui consultait pour des douleurs scrotales évoluant depuis huit mois. L'examen clinique a mis en évidence une tuméfaction mobile, inguino-scrotale, droite. L’échographie testiculaire a objectivé une hernie inguinale droite associée à deux kystes épididymaires bilatéraux. Le patient a été opéré pour cure de son hernie avec découverte en per-opératoire d'un kyste du cordon spermatique qui a été réséqué. L'examen anatomopathologique a conclu à une hydatidose du cordon spermatique.

Hamdane, Mohamed Moncef; Bougrine, Fethi; Msakni, Issam; Dhaoui-Ghozzi, Amen; Bouziani, Ammar

2011-01-01

229

Quantitative Serial Imaging of an 124I Anti-CEA Monoclonal Antibody in Tumor-Bearing Mice  

PubMed Central

Abstract Objective: The 4.2-day half-life of 124I favors its use for positron emission tomography (PET) of monoclonal antibodies (mAbs). However, high positron energy and ?+-associated cascade ? rays pose image resolution and background noise problems for 124I. This study evaluated quantitative PET of an 124I mAb in tumor-bearing mice. Methods: An R4 microPET™ (Siemens/CTIMI, Knoxville, TN) was used with standard energy and coincidence timing windows (350–750?keV and 6 ns, respectively), delayed random coincidence subtraction, iterative image reconstruction, and no attenuation or scatter correction. Image resolution, contrast, and response linearity were compared for 124I and 18F, using phantoms. Nude mice bearing human colon tumors (LS-174T) were injected intravenously with a chimeric 124I anti-CEA mAb (cT84.66) and imaged serially 1 hour to 7 days postinjection. Venous blood was sampled to validate image-derived blood curves. Mice were sacrificed after the final scan, and the biodistribution of 124I was measured by direct tissue assay. Images were converted to units of kBq/g for each tissue of interest by comparing the final scans with the direct assays. Results: Measured resolution (FWHM) 0–16?mm from the scanner axis was 2.3–2.7?mm for 124I versus 1.9–2.0?mm for 18F. Due to true coincidence events between annihilation photons and cascade ? rays, background was greater for 124I than 18F, but the signal-to-background ratio was still more than 20, and 124I image intensities varied linearly with activity concentration. Tissue-based calibration worked well (i.e., PET blood curves agreed with direct measurements within 12% at all time points), while calibration, based on a cylindrical phantom approximating the mouse body, yielded tumor quantitation that was 46%–66% low, compared with direct assay. Conclusions: Images of quantitative accuracy sufficient for biodistribution measurements can be obtained from tumor-bearing mice by using 124I anti-CEA mAbs with standard microPET acquisition and processing techniques, provided the calibration is based on the direct assay of excised tissue samples.

Horling, Magnus; Williams, Lawrence E.; Colcher, David; Raubitschek, Andrew; Strand, Sven E.

2008-01-01

230

M?tastase pancr?atique m?tachrone du cancer du rein : ? propos d'un cas  

PubMed Central

Résumé Les métastases pancréatiques du cancer du rein sont rares et surviennent le plus souvent plusieurs années après la néphrectomie. Le traitement chirurgical est souvent possible, permettant une bonne survie à distance. Nous rapportons le cas d’une métastase pancréatique métachrone d’un carcinome rénal à cellules claires 16 ans après la néphrectomie.

Mqirage, Mohammed; Egurrola, Jose Antonio Zabala; Rodriguez, Jorge Garcia-Olaverri; Pena, Carlos Pertusa

2013-01-01

231

Rattachement hiérachique du contrôleur de gestion, perception du contrôle de gestion et qualité des relations contrôleurs - manageurs : une étude exploratoire  

Microsoft Academic Search

La recherche proposée étudie le lien existant entre le rattachement hiérarchique du contrôleur de gestion et la perception du contrôle de gestion par les directeurs de l'entité pour laquelle travaille le contrôleur ainsi que par les opérationnels, ainsi que le lien rattachant cette perception et la qualité des relations contrôleurs \\/ directeurs et contrôleurs \\/ opérationn

Armelle Godener; Marianela Fornerino

2004-01-01

232

Annuaire du Bureau des longitudes - 2006  

NASA Astrophysics Data System (ADS)

This annual publication provides ephemerides and data to the use of professionnal and amateur astronomers. Divided in 11 chapters it covers concordance of various calendars, explanation of fondamental astronomy and various time scales, explanation for the use of ephemerides; tables provide ephemerides (positions, rise/set/passage) of the Sun and the Moon, planets, planetary satellites, asteroids, comets, bright stars; data and explanation for the physical observation of the surface of the Sun, the Moon, and planets; chart of the sky and a list of constellations and galaxies; prediction and ephemerides for astronomical phenomenon: occultation by the moon, stellar occultations by asteroids and appulses, solar eclipses and lunar eclipses; and an additional review about a hot scientific topic, this year: "Legendre et le méridien terrestre, 200 ans après". Cette publication annuelle fournit des éphémérides et des données à l'usage des astronomes professionnels et des astronomes amateurs. Composée de 11 chapitres elle comprend les rubriques sur les différents calendriers et leurs concordance, les fêtes légales en France, les dates et décrets sur les heures légales en France métropolitaine ; une introduction à l'astronomie fondamentale et aux différentes échelles de temps, des explications sur l'utilisation des éphémérides ; des tables fournissent les éphémérides (positions, heures de lever/coucher/passage) du Soleil et de la Lune, de planètes, de satellites naturels, d'astéroïdes, de comètes, d'étoiles brillantes ; des données pour l'observation de la surface du Soleil, de la Lune, et des planètes ; des cartes du ciel ainsi qu'une liste de constellations et de galaxies ; des prédictions des phénomènes astronomiques : occultation par la Lune, occultation stellaires par des astéroïdes et appulses, éclipses de Soleil et de la Lune; la liste et les coordonnées des observatoires astronomiques les plus connus ; et enfin un cahier thématique sur un sujet d'actulaité, pour cette année : "Legendre et le méridien terrestre, 200 ans après".

Imcce; Bureau Des Longitudes

2005-07-01

233

De Simone de Beauvoir à Virginie Despentes: les intellectuelles et la question du genre  

Microsoft Academic Search

Dans les dernières décennies du XX siècle, la manière d'étudier la situation des femmes a changé. Des women's studies on est passé aux gender studies, mettant au centre des travaux la notion du genre, du sexe social, qui se distingue de plus en plus du sexe biologique. En France, comme dans d'autres pays, les intellectuelles ne sont pas accordées, loin

Janine Mossuz-Lavau

2009-01-01

234

L'artisanat du bâtiment : un monde en transition (Première partie)  

Microsoft Academic Search

[fre] L'artisanat du bâtiment : un monde en transition par Jean LAFONT et Danièle LEBORGNE . Le bâtiment est un des derniers secteurs qui semble avoir échappé jusqu'ici à la révolution industrielle, et dans lequel le nombre des entreprises artisanales reste très élevé (environ 220 000 entreprises de 5 salariés au maximum). L'artisanat du bâtiment représente plus du quart du

Danièle Leborgne; Jean Lafont

1974-01-01

235

Pyrrole: From Dippel to Du Pont  

NASA Astrophysics Data System (ADS)

The preacher-alchemist Johann Konrad Dippel made an oil by the destructive distillation of bones about 1700. He proclaimed it to be a universal remedy. Much later Ferdinand Runge detected the presence of pyrrole, but not in bone oil. He observed the red color of the pine splint wet with hydrochloric acid in the vapor of coal tar distillate, and called the responsible substance pyrrole. He suggested that it might also occur in bone oil. In the mid-1880's, Thomas Anderson finally isolated pyrrole by repeated distillation of about 250 gallons of ivory oil. About the middle of this century Du Pont began to make it synthetically.

Anderson, Hugh J.

1995-10-01

236

Evolution of a Tumorigenic Property Conferred by Glycophosphatidyl-Inositol Membrane Anchors of Carcinoembryonic Antigen Gene Family Members during the Primate Radiation  

PubMed Central

GPI membrane anchors of cell surface glycoproteins have been shown to confer functional properties that are different from their transmembrane (TM)-anchored counterparts. For the human carcinoembryonic antigen (CEA) family, a subfamily of the immunoglobulin superfamily, conversion of the mode of membrane linkage from TM to GPI confers radical changes in function: from tumor suppression or neutrality toward inhibition of differentiation and anoikis and distortion of tissue architecture, thereby contributing to tumorigenesis. We show here that GPI anchorage in the CEA family evolved twice independently in primates, very likely from more primitive TM anchors, by different packages of mutations. Both mutational packages, one package found in many primates, including humans, and a second, novel package found only in the Cebidae radiation of New World monkeys, give rise to efficiently processed GPI-linked proteins. Both types of GPI anchors mediate inhibition of cell differentiation. The estimated rate of nonsynonymous mutations (Ka) in the anchor-determining domain for conversion from TM to GPI anchorage in the CEA family that were fixed during evolution in these primates is 7 times higher than the average Ka in primates, indicating positive selection. These results suggest therefore that the functional changes mediated by CEA GPI anchors, including the inhibition of differentiation and anoikis, could be adaptive and advantageous.

Naghibalhossaini, Fakhraddin; Yoder, Anne D.; Tobi, Martin

2007-01-01

237

Diagnostic value of CEA, CA 15-3, CA 19-9, CYFRA 21-1, NSE and TSA assay in pleural effusions  

Microsoft Academic Search

The aim of this study was to evaluate the individual and combined diagnostic utility of six tumor markers in patients with pleural effusion. Pleural and serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen 15-3 (CA 15-3), carbohydrate antigen 19-9 (CA 19-9), cytokeratin fragment 19 (CYFRA 21-1), neuron-specific enolase (NSE) and total sialic acid (TSA) were assayed in 74 patients with

F Alata?; Ö Alata?; M Metinta?; Ö Çolak; E Harmanci; S Demir

2001-01-01

238

Anisotropic exchange and spin dynamics in the type-I (IA) antiferromagnets CeAs, CeSb, and USb: A neutron study  

Microsoft Academic Search

The anomalous anisotropic magnetic interactions and the spin dynamics of the fcc type-I or -IA antiferromagnetic cerium and uranium monopnictides CeAs, CeSb, and USb have been studied by inelastic and diffuse critical neutron scattering experiments. The diffuse scattering above the antiferromagnetic ordering temperature largely corresponds to longitudinal spin fluctuations which are highly anisotropic. In the ordered state the dispersion curves

B. Hälg; A. Furrer

1986-01-01

239

Brain metastasis development and poor survival associated with carcinoembryonic antigen (CEA) level in advanced non-small cell lung cancer: a prospective analysis  

Microsoft Academic Search

BACKGROUND: Central nervous system is a common site of metastasis in NSCLC and confers worse prognosis and quality of life. The aim of this prospective study was to evaluate the prognostic significance of clinical-pathological factors (CPF), serum CEA levels, and EGFR and HER2 tissue-expression in brain metastasis (BM) and overall survival (OS) in patients with advanced NSCLC. METHODS: In a

Oscar Arrieta; David Saavedra-Perez; Roberto Kuri; Alejandro Aviles-Salas; Luis Martinez; Daniel Mendoza-Posada; Patricia Castillo; Alma Astorga; Enrique Guzman; Jaime De la Garza

2009-01-01

240

Clinical utility of CEA, CA 19-9, and CA 72-4 in the follow-up of patients with resectable gastric cancer  

Microsoft Academic Search

Background: The aim of this longitudinal study was to evaluate the effectiveness of the serum tumor markers CEA, CA 19-9, and CA 72-4 in the early diagnosis of recurrence of gastric cancer.Methods: One hundred and thirty-three patients who had undergone potentially curative surgery were considered. Serum samples were obtained preoperatively, 1 week after surgery, and at every follow-up examination. Mean

Daniele Marrelli; Enrico Pinto; Alfonso De Stefano; Maurizio Farnetani; Lorenzo Garosi; Franco Roviello

2001-01-01

241

Serum HCG? and CA 72-4 Are Stronger Prognostic Factors than CEA, CA 19-9 and CA 242 in Pancreatic Cancer  

Microsoft Academic Search

Objective: In pancreatic cancer, the extent of the spread of the disease is considered to be the strongest prognostic factor. In addition, tumor markers, particularly CA 19-9, may also provide prognostic information. In this study, we evaluated the prognostic value of serum tumor markers CEA, CA 19-9, CA 242, CA 72-4 and hCG? in pancreatic cancer. Methods: Preoperative serum samples

Johanna Louhimo; Henrik Alfthan; Ulf-Håkan Stenman; Caj Haglund

2004-01-01

242

Results of 2007 Ect Benchmark Obtained with Civa at Cea: Prediction of Ect Inspection Over Tubes with 2d or 3d Flaws  

NASA Astrophysics Data System (ADS)

The French Atomic Energy Commission (CEA) has developed for years the software CIVA dedicated to the simulation of NDT techniques such as Eddy Current Testing (ECT). ECT modeling is achieved in CIVA using semi-analytical models based on the Volume Integral Method (VIM). This paper presents results obtained with CIVA for the QNDE 2007 ECT benchmark, dedicated to the inspection of tube affected by 2D and 3D flaws. Further configurations are also proposed for future benchmark sessions.

Pichenot, G.; Reboud, C.; Raillon, R.; Mahaut, S.

2008-02-01

243

Agreement on Scientific and Technical CO-Operation in the Peaceful Uses of Nuclear Energy Between the National Laboratory of Industrial Engineering and Technology (LNETI) And the Commissariat a l'Energie Atomique (CEA).  

National Technical Information Service (NTIS)

This Agreement on scientific and technical co-operation in the nuclear field was signed between the French Atomic Energy Commission (CEA) and the Portuguese National Laboratory of Industrial Engineering and Technology (LNETI). The Agreement covers, inter ...

1980-01-01

244

Neurotransmetteurs cérébraux et contrôle du comportement sexuel masculin  

Microsoft Academic Search

Resume  Des progrès importants, quoiqu'encore parcellaires, ont été accomplis dans la compréhension du rôle que jouent les neurotransmetteurs\\u000a mono-aminergiques et peptidergiques dans le contrôle du comportement sexuel (CS) animal, et à un moindre degré humain. Parmi\\u000a les mono-amines, la dopamine stimule tous les aspects du CS chez l'animal et au moins l'érection chez l'homme. La noradrénaline\\u000a semble impliquée dans un tonus

J. Buvat

1996-01-01

245

Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR  

Microsoft Academic Search

We have compared three different RT-PCR procedures to measure cytokeratin 19 (CK19), carcinoembryonic antigen (CEA) and mucin MUC1 gene expression in order to determine their diagnostic value in detecting tumour cells in bone marrow aspirates of patients with operable breast cancer. In an experimental model, the best sensitivity was observed for CK19 and MUC1 RT-PCR assays, although only the CEA

N Berois; M Varangot; B Aizen; R Estrugo; L Zarantonelli; P Fernández; G Krygier; F Simonet; E Barrios; I Musé; E Osinaga

2000-01-01

246

Tumor marker utility and prognostic relevance of cathepsin B, cathepsin L, urokinase-type plasminogen activator, plasminogen activator inhibitor type-1, CEA and CA 19-9 in colorectal cancer  

Microsoft Academic Search

BACKGROUND: Cathepsin B and L (CATB, CATL), urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 play an important role in colorectal cancer invasion. The tumor marker utility and prognostic relevance of these proteases have not been evaluated in the same experimental setting and compared with that of CEA and CA-19-9. METHODS: Protease, CEA and CA 19-9 serum or plasma levels

László Herszényi; Fabio Farinati; Romilda Cardin; Gábor István; László D Molnár; István Hritz; Massimo De Paoli; Mario Plebani; Zsolt Tulassay

2008-01-01

247

Changements climatiques récents et modification du régime hydrologique du fleuve Niger à Koulikoro (Mali)  

Microsoft Academic Search

Résumé Depuis une vingtaine d'années, le bassin du fleuve Niger et ceux des principaux cours d'eau africains sont soumis à un déficit pluvio- métrique important. La chronique des débits enregistrés à Koulikoro (120 000 km2) montre une décroissance persistante des écoulements. Cependant la baisse des pluies n'est que de 20% en valeur moyenne décennale entre 1951\\/1960 et 1981\\/1989, alors que

J. P. BRIQUET; G. MAHE; F. BAMBA; J. C. OLIVRY

248

Annuaire du bureau des Longitudes : guide de données astronomiques 2011 pour l'observation du ciel  

NASA Astrophysics Data System (ADS)

Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

2010-07-01

249

Annuaire du Bureau des Longitudes. Guide de données astronomiques 2008 pour l'observation du ciel  

NASA Astrophysics Data System (ADS)

Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

Institut de Mécanique Céleste Et de Calcul Des Éphémerides (Imcce)

2007-06-01

250

Annuaire du bureau des Longitudes : guide de données astronomiques 2012 pour l'observation du ciel  

NASA Astrophysics Data System (ADS)

Destiné aux astronomes, professionnels ou amateurs, cet ouvrage se décompose de la façon suivante : Les trois premiers chapitres de cet ouvrage contiennent : les données sur les différents calendriers et leur concordance, les fêtes légales en France, les différentes échelles de temps, les dates de décrets sur les heures légales en France métropolitaine parues au Journal Officiel depuis 1916 ; des notions nécessaires à la compréhension et à l'emploi des éphémérides contenues dans l'ouvrage. Les chapitres suivant fournissent des éphémérides astronomiques : les positions du Soleil et de la Lune ; les positions des planètes et de leurs satellites ; les positions des astéroïdes et des comètes ; les explications et des données pour l'observation de la surface du Soleil, de la Lune et des planètes ; des cartes du ciel, une liste de constellations et les positions et occultations des étoiles ; des données sur les éclipses de Soleil et de Lune et sur les phénomènes astronomiques ; la liste des observatoires astronomiques les plus connus.

Institut de Mécanique Céleste Et de Calcul Des Ephémérides (Imcce); Bureau Des Longitudes (Bdl)

2011-07-01

251

Immunoassay for CEA using the novel probe-labeled Ag nanoparticles based on surface-enhanced Raman scattering  

NASA Astrophysics Data System (ADS)

In this study, we report the Ag nanoparticles aggregated in the process of the labeling that use the crystal violet as the Raman probe. After this process- immune nanoparticles aggregate with high SERS sensitivity and biological specificity are created. We track and characterize the preparation by employing UV-Vi absorption spectra, Transmission Electron Microscope (TEM) and SERS spectra. With the increase of crystal violet, the aggregate of the Ag nanoparticles also increase, while the intensity of absorption peaks decrease. When the concentration of crystal violet reaches 1.0×10-4 mol/L, new peaks were found in the long wavelengths, and with the increase of the crystal violet, the intensity of the new peaks increase as well. We observe from the TEM, that with the increase of crystal violet, the aggregation degree of the Ag nanoparticles also increase and then they unite together. The SERS activity of the aggregates was directly related to the aggregation degree. Detecting the SERS activity of Ag NPs aggregates labeled with different amount of crystal violet, we found that with the increase of the crystal violet, the SERS signals of NPs aggregates enhanced. However, when the amount of crystal violet exceeded 25?L in 1mL colloidal silver, the Ag NPs occurred agglomeration and thereafter the next preparation of immune-label aggregates was hindered. Whereas, the probe labelled with 12?L crystal violet exhibited a better stability, stronger SERS activity and higher biological specificity, and it may accomplish a highly efficient SERS-based immunoassay. This immune probe was applied for detecting the expression of carcinoembryonic antigen (CEA) in the colon cancer tissue slice. Results show that appropriate immune aggregates labelled with optimum quantity of crystal violet present high stability, strong SERS activity and good immune specificity, which are expected to be applied in the analysis of the protein expression in the tissue section and promising for developing into a clinical tool for diagnosis.

Lin, Xiaoqian; Xi, Gangqin; Chen, Yanping; Chen, Gang; Zheng, Xiongwei; Lei, Jinping; Ou, Lin; Feng, Shangyuan; Zeng, Haishan; Chen, Rong; Sun, Liqing

2011-11-01

252

Influence d'une substitution partielle du ciment par du laitier de hauts fourneaux sur la résistance des mortiers en milieu acide  

Microsoft Academic Search

Le stockage de produits chimiques dans du béton présente souvent des problèmes de durabilité dus aux attaques chimiques. Inévitablement les concentrations élevées sont les plus dangereuses. Le but de notre étude est de déterminer les changements de phases qui apparaissent dans le béton lorsqu'on substitue une partie du ciment par du laitier de haut fourneaux. Les échantillons sont conservés dans

D. Achoura; Ch. Lanos; R. Jauberthie; B. Redjel

2004-01-01

253

Human Evolution  

NSDL National Science Digital Library

The first Web site is an article from the New York Times (1) detailing some recent fossil discoveries that are shaking the paleontological world (free registration is required). Another relatively recent article from Guardian Unlimited (2) discusses a scientific debate surrounding the question of whether "a Western lifestyle now protects humanity from the forces that used to shape Homo sapiens." The third resource (3) includes a likely timeline of events in the history of hominids and a tour of the fossil record. A second timeline from the Huntarian Museum and Art Gallery at the University of Glasgow (4) is less detailed, but links to many major fossil discoveries of human and pre-human history. An "overview of the study of human evolution, and of the currently accepted fossil evidence" (5) is used to inform arguments for creationists and evolutionists. An interesting site from the University of California Santa Barbara (6) (last mentioned in the December 1, 1998 Scout Report for Social Sciences) presents 3-dimensional views of "modern primate relatives and fossil ancestors of humans." The interactive documentary from the Institute of Human Origins (7) (last mentioned in the April 20, 2001 Scout Report) is a great resource for those with the Flash plug-in and a high speed connection. Lastly, a resource from PBS.org (8) focuses on human evolution in a format aimed at kids.

Lee, Amy.

2002-01-01

254

1. Historic American Buildings Survey, drawn by Pierre du Simitiere ...  

Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

1. Historic American Buildings Survey, drawn by Pierre du Simitiere (papers in Philadelphia Library) DRAWING OF REDWOOD LIBRARY IN 1768. - Redwood Library, 50 Bellevue Avenue, Newport, Newport County, RI

255

Évolution nycthémérale des composantes biochimiques du phytoplancton de la retenue du barrage Idriss premier (Fès, Maroc)  

NASA Astrophysics Data System (ADS)

The diel changes of the biochemical composition of the phytoplankton were studied in the Idriss first reservoir (located on the Inaouen river at thirty Km from the city of Fes, Morrocco) during September 1994. Several biomass and metabolic indicators (proteins, carbohydrates, lipids, chlorophyll a and primary production) were assessed every fourth hour over tow days (7, 8 and 9 September). Since the Protein/Carbohydrates ratio (P/C) is largely recognised as a good integrator of the metabolic functions of the cells, we examined its distribution pattern concomitantly with aforementioned parameters. The results demonstrated enhanced P/C ratios clearly indicating that nutrients were sufficiently available for growth. In addition, this index showed a diel significant variation with levels higher in the night than in the day. Moreover, these results suggest that phytoplankton species during the night used the day-synthesised carbohydrates to insure the cell metabolic functioning. The P/C presents relatively high values in proposition to the ones that have been recorded in temperate regions, and seems to be related to azotic inputs of the Inaouen river. Dans le but de parfaire nos connaissances sur le fonctionnement du sous écosystème phytoplancton, nous nous sommes intéressés à étudier son cycle nycthéméral et son métabolisme cellulaire dans la retenue du barrage Idriss premier. Cette dernière, construite sur l'Oued Inaouène, est située à une trentaine de Km de la ville de Fès. Au cours de ce cycle, les prélèvements ont été effectués selon une séquence temporelle de 4 heures pendant 48 heures, les 7, 8 et 9 septembre 1994. L'étude de l'évolution des composantes biochimiques des cellules phytoplanctoniques à savoir les protéines, les glucides et les lipides a permis de mettre en évidence des variations nycthémérales importantes. Ces variations sont d'autant plus importantes que les variations spatiales observées entre les profondeurs. De plus, le rapport protéines/glucides (P/G), reconnu comme un bon indicateur de l'état physiologique des algues, présente des valeurs plus élevées la nuit que le jour au niveau du fond du lac. Ce résultat suggère que le phytoplancton utilise les produits de réserve synthétisés le jour pour assurer le fonctionnement métabolique des cellules. De plus, les valeurs de ce rapport sont relativement élevées par rapport à celle enregistrées dans les régions tempérés et semblent être liées aux ressources azotées du milieu en particulier les apports de l'Oued Inaouène.

Bahhou, J.; Alaoui Mhamdi, M.

1999-03-01

256

La nutrition du nourrisson n? ? terme et en sant?  

PubMed Central

La nutrition du nourrisson né à terme et en santé constitue le nouvel énoncé national sur la nutrition du nourrisson, de la naissance à l’âge de 24 mois. Il s’agit d’un projet conjoint de la Société canadienne de pédiatrie, des Diététistes du Canada et de Santé Canada. Cet ouvrage est une synthèse de la documentation scientifique actuelle en matière de nutrition du nourrisson ; il contient des principes et recommandations afin d’aider les professionnels de la santé à promouvoir la prestation des meilleurs soins alimentaires possibles pour les nourrissons du Canada, compte tenu de l’état actuel de la recherche. La collaboration entre les trois principaux organismes qui s’intéressent à cette question a permis d’uniformisé le message que les professionnels transmettront au public. Le document aborde quatre grands sujets relatifs à la première année d’existence : l’allaitement, les laits de remplacement, les autres liquides dans le régime du nourrisson et la transition aux aliments solides. On y examine ensuite la question de la sécurité dans l’alimentation, puis celle de la nutrition durant la deuxième année. La dernière section couvre les autres questions liées à la nutrition du nourrisson ; on y traite de sujets tels que les allergies alimentaires, les coliques, la constipation, les matières grasses dans le régime alimentaire, la carie dentaire, la gastroentérite, le diabète, l’anémie ferriprive et les régimes végétariens. Le document contient également un répertoire complet de plus de 200 citations. Le sommaire des principes et recommandations paraîtra dans les revues officielles de la Société canadienne de pédiatrie (Paediatrics and Child Health, 1998) et des Diététistes du Canada (Revue canadienne de pratique et de recherche en diététique, juin 1998). On peut télécharger le document intégral à partir des sites Web respectifs des trois organismes associés ; on peut aussi obtenir la version imprimée de l’Énoncé, en français ou en anglais, auprès de la Société canadienne de pédiatrie, des Diététistes du Canada ou de Santé Canada. Avec La nutrition du nourrisson né à terme et en santé, les professionnels de la santé de toutes disciplines disposent d’un outil scientifique à la fine pointe pour conseiller les parents et exercer une influence positive sur l’environnement nutritionnel qui s’offre aux nourrissons du Canada.

1998-01-01

257

Un scénario de rééquilibrage du solde courant américain  

Microsoft Academic Search

[fre] Le déficit de la balance des paiements courants des États-Unis n'a cessé de s'aggraver ces dernières années. La prise de conscience du caractère de plus en plus inquiétant de ce déficit a débouché, à la fin de l'été 1 985, sur une action coordonnée au plan international (accord du Groupe des Cinq, 22 septembre 1 985) visant en particulier

Ronan Le Berre; François Cellier

1987-01-01

258

Couverture du risque de chômage : éléments de comparaisons internationales  

Microsoft Academic Search

[fre] Couverture du risque de chômage : éléments de comparaisons internationales . Les systèmes d'indemnisation du chômage ont été instaurés à une époque où les taux de chômage étaient en général plus faibles qu'aujourd'hui. En France comme à l'étranger, ils furent conçus pour pallier des pertes de revenus liées à un chômage frictionnel et de courte durée. Le risque chômage

Cécile Lefèvre

1996-01-01

259

Prise en charge du paludisme pédiatrique: rôle des interventions nutritionnelles  

Microsoft Academic Search

RésuméLe paludisme est la principale cause de morbidité et de mortalité chez l’enfant, particulièrement en Afrique sub-saharienne. Malgré des progrès substantiels du traitement du paludisme pédiatrique au moyen de polythérapies basées sur l’artémisinine, de nombreux obstacles s’opposent encore à la mise en œuvre efficace de ces nouvelles options thérapeutiques très efficaces. De même, des moyens efficaces sont disponibles pour la

Akato Kwame Osei; Davidson H. Hamer

2008-01-01

260

Le Massif volcanique du Dalai-nor (Gobi Oriental)  

Microsoft Academic Search

\\u000a Conclusion  L’étude de la région volcanique du Dalai-nor , en établissant l’existence de vastes éruptions pliocènes el récentes au Sud\\u000a de la Mongolie , est susceptible de modifier sur plusieurs points les conceptions que les géologues se faisaient jusqu’ici\\u000a des basaltes de Chine. Ces basalles, largement répandus ta (à la manière des rhyolites mésozoïqurs) tout autour du haut Plateau\\u000a mongol, depuis

P. Teilhard de Chardin

1925-01-01

261

The History of Managing Technical Information at DuPont  

Microsoft Academic Search

In the 1960s, DuPont developed computer databases to manage its collec- tion of technical information, and many of the individual departments had their own information centers. During this time the duplication of efforts between departments, es- pecially in the area of patent services, was studied. These studies had an impact on the handling of proprietary technical information. DuPont then developed,

Florence H. Kvalnes

262

The biokinetics of uranium migrating from embedded DU fragments.  

PubMed

Military uses of depleted uranium (DU) munitions have resulted in casualties with embedded DU fragments. Assessment of radiological or chemical health risks from these fragments requires a model relating urinary U to the rate of migration of U from the fragments, and its accumulation in systemic tissues. A detailed biokinetic model for U has been published by the International Commission on Radiological Protection (ICRP), but its applicability to U migrating from embedded DU fragments is uncertain. Recently, Pellmar and colleagues (1999) conducted a study at the Armed Forces Radiobiology Research Institute (AFRRI) on the redistribution and toxicology of U in rats with implanted DU pellets, simulating embedded fragments. This paper compares the biokinetic data from that study with the behavior of commonly studied forms of U in rats (e.g., intravenously injected U nitrate). The comparisons indicate that the biokinetics of U migrating from embedded DU is similar to that of commonly studied forms of U with regard to long-term accumulation in kidneys, bone, and liver. The results provide limited support for the application of the ICRP's model to persons with embedded DU fragments. Additional information is needed with regard to the short-term behavior of migrating U and its accumulation in lymph nodes, brain, testicles, and other infrequently studied U repositories. PMID:12500806

Leggett, R W; Pellmar, T C

2003-01-01

263

Effets du titane et du niobium sur l'oxydation à 950circC d'aciers ferritiques  

NASA Astrophysics Data System (ADS)

Nous avons étudié l'effet du titane et du niobium sur l'oxydation à 950circC d'un acier Fe-Cr chrominoformeur. La DRX in situ montre que le titane semble s'oxyder en formant Cr{2}TiO{5} et TiO{2} qui contribuent à une augmentation de la prise de masse des échantillons. Une partie du titane issu de ces oxydes semble doper la couche de chromine. Sa présence augmente la concentration en lacunes cationiques dans la chromine et augmente donc la diffusion du chrome dans la couche. Nous avons aussi montré que le niobium n'a pas d'influence sur l'oxydation de ce type d'acier à 950circC.

Issartel, C.; Buscail, H.; Caudron, E.; Cueff, R.; Riffard, F.; El Messki, S.; Karimi, N.; Antoni, L.

2004-11-01

264

Viral evolution  

NASA Astrophysics Data System (ADS)

In the last two decades, viruses have been used as model systems to study evolution in short periods of time. Due to their characteristics, virus adapt rapidly to changing conditions, thus allowing the quantification of several evolutionary features under controlled laboratory conditions. Here we review the basic biology of viruses and describe in detail a number of experiments performed with RNA viruses. Particular emphasis is devoted to the interpretation of the experiments and to the involved phenomenology. This analysis sometimes represents the basis to formulate simple evolutionary models that aim at describing the observed dynamics. In other cases, theoretical results have prompted the realization of related experiments, as we discuss. Concepts as fitness loss and fitness recovery, the error threshold, increased mutagenesis, viral sex, or viral competition and interference, are discussed in an empirical framework and from the associated theoretical point of view.

Manrubia, Susanna C.; Lázaro, Ester

2006-06-01

265

Indications, contre–indications, résultats attendus et choix de la chimiothérapie néo–adjuvante du cancer du sein opérable  

Microsoft Academic Search

Résumé: La chimiothérapie néoadjuvante du cancer du sein correspond à l’utilisation d’un traitement cytostatique systémique avant le traitement locorégional (chirurgie et\\/ou radiothérapie). Initiée dans les années 1970 pour le traitement des formes localement avancées et\\/ou inflammatoires, la chimiothérapie d’induction s’est étendue au début des années 1980 aux cancers dits opérables, de taille supérieure à 3 cm et\\/ou de position centrale

H. Curé; C. Abrial; S. Amat; I. Van Praagh; P. Chollet

2004-01-01

266

La répartition des exploitations dans l'agriculture française à la fin du XIXe et au début du XXe siècle  

Microsoft Academic Search

[fre] La répartition des exploitations dans l'agriculture française, à la fin du XIXe et au début du XXe siècle. . Les résultats des enquêtes décennales de 1862, 1882 et 1892, ainsi que le recoupement des données fournies par l'enquête de 1908-1909 sur la petite propriété rurale au moyen de documents d'origines diverses, permettent de mettre au jour les mouvements qui

Jean Ibanès

1974-01-01

267

CEA (Carcinoembryonic Antigen) Test  

MedlinePLUS

... Clarke, W., Editor (© 2011). Contemporary Practice in Clinical Chemistry 2nd Edition: AACC Press, Washington, DC. Pp 244-245. Tietz Textbook of Clinical Chemistry and Molecular Diagnostics. Burtis CA, Ashwood ER, Bruns ...

268

Expression of a Neuroendocrine Gene Signature in Gastric Tumor Cells from CEA 424-SV40 Large T Antigen-Transgenic Mice Depends on SV40 Large T Antigen  

PubMed Central

Background A large fraction of murine tumors induced by transgenic expression of SV40 large T antigen (SV40 TAg) exhibits a neuroendocrine phenotype. It is unclear whether SV40 TAg induces the neuroendocrine phenotype by preferential transformation of progenitor cells committed to the neuroendocrine lineage or by transcriptional activation of neuroendocrine genes. Methodology/Principal Findings To address this question we analyzed CEA424-SV40 TAg-transgenic mice that develop spontaneous tumors in the antral stomach region. Immunohistology revealed expression of the neuroendocrine marker chromogranin A in tumor cells. By ELISA an 18-fold higher level of serotonin could be detected in the blood of tumor-bearing mice in comparison to nontransgenic littermates. Transcriptome analyses of antral tumors combined with gene set enrichment analysis showed significant enrichment of genes considered relevant for human neuroendocrine tumor biology. This neuroendocrine gene signature was also expressed in 424GC, a cell line derived from a CEA424-SV40 TAg tumor, indicating that the tumor cells exhibit a similar neuroendocrine phenotype also in vitro. Treatment of 424GC cells with SV40 TAg-specific siRNA downregulated expression of the neuroendocrine gene signature. Conclusions/Significance SV40 TAg thus appears to directly induce a neuroendocrine gene signature in gastric carcinomas of CEA424-SV40 TAg-transgenic mice. This might explain the high incidence of neuroendocrine tumors in other murine SV40 TAg tumor models. Since the oncogenic effect of SV40 TAg is caused by inactivation of the tumor suppressor proteins p53 and RB1 and loss of function of these proteins is commonly observed in human neuroendocrine tumors, a similar mechanism might cause neuroendocrine phenotypes in human tumors.

Ihler, Fritz; Vetter, Elena Viviana; Pan, Jie; Kammerer, Robert; Debey-Pascher, Svenja; Schultze, Joachim L.

2012-01-01

269

A comparative study of mucin-like carcinoma-associated antigen (MCA), CA 125, CA 19-9 and CEA in patients with ovarian cancer.  

PubMed

A mucin-like carcinoma associated antigen (MCA), which is recognized by the monoclonal antibody b-12, was found to be elevated in sera of breast cancer patients. Since an immunohistochemical reaction of the monoclonal antibody b-12 was found in epithelial tumors of the ovary we investigated MCA serum levels in 50 patients with ovarian cancer (mean age 59 years, range 31-81 years). In addition, CA 125, CA 19-9 and CEA were determined to compare sensitivity, specificity and the predictive value of the positive test of each parameter used in this study. Blood samples were obtained in 20 patients with progressive disease and in 30 patients during disease free intervals. The MCA serum levels of patients with progressive ovarian cancer (mean +/- SD: 14.7 +/- 14.6 U/ml) did not differ significantly from those of patients in remission (mean +/- SD: 8.2 +/- 5.3 U/ml) or from values of a healthy control group (mean +/- SD: 7.7 +/- 3.8 U/ml, n = 70). Women with progressive disease displayed significantly higher CA 125 (p less than 0.0001) and CEA (p less than 0.0063) serum levels than patients in remission. No significant difference was found for CA 19-9 in patients with ovarian cancer, irrespective of the clinical status. Considering marker surge and tumor progression, the highest sensitivity was found for CA 125 (75%). Sensitivities of the other markers were significantly lower and reached only 25-35%. The predictive value of elevated marker levels as well as specificity of the marker substances were similar. Sensitivity could be extended to 90% if elevation of CA 125, CA 19-9, CEA and MCA were taken into consideration, however specificity was lowered by using this marker combination. PMID:2770933

Koelbl, H; Schieder, K; Neunteufel, W; Bieglmayer, C

1989-01-01

270

Changes of Serum Trace Elements, AFP, CEA, SF, T3, T4 and IGF-II in Different Periods of Rat Liver Cancer  

PubMed Central

Objective Based on liver cancer model built in SD rats, the contents of trace elements (Cu, Fe, Zn, Ca and Mg), AFP, CEA, SF, TH and IGF-II in serum were measured at different stages to explore the molecular changes during the rat liver cancer development. Methods The SD rat liver cancer model was built by using diethylnitrosamine (DENA) as the mutagen. During 16 weeks of DENA gavage, blood samples were taken in the 14th, 28th, 56th, 77th, 105th and 112th days respectively after the first day of gavage with DENA, then the contents of five trace elements (Cu, Fe, Zn, Ca and Mg), T3, T4, IGF-II, AFP, CEA and SF in serum were determined. Results During the development of the rat liver cancer, in the test group, the Cu content significantly increased in serum, while the contents of Fe, Zn and Ca significantly decreased. The content of Mg showed no significant change. AFP and CEA of the test group showed same expression level with the control group; while the content of SF was lower than that of the control group when cancerization appeared. T3 and T4 increased at the first stage and then went down, and the content of IGF-II was always high. Conclusion Cu, Fe, Zn, Ca, T3, T4, SF and IGF-II are closely related to the development of liver cancer. The changes of their contents in the development of cancer could enlighten the researches on cancer pathogenesis and prevention.

Liu, Dan-dan; Jin, Bai-jie; Wang, Ya-wei; Liu, Qi; Duan, Ru-bing; Zhao, Peng; Ma, Ming-xia

2011-01-01

271

Analyse Statistique des Anisotropies du Fond Diffus Cosmologique  

NASA Astrophysics Data System (ADS)

Les détections de fluctuations de température du fond diffus cosmologique (CMB pour''Cosmic Microwave Background'' ) s'accumulent depuis près de 10 ans.La connaissance du spectre angulaire des fluctuations nous permet d'avoir accès à la physique de l'universlorsqu'il avait environ100 000 ans et donc de déterminerles paramètres cosmologiques.Ce manuscrit présentedifférentes méthodes statistiques qui permettent de passer de l'information disponible sur les observations du CMB aux paramètres cosmologiques. Après unedescription du CMB au sein du modèle du Big-Bang et de l'inflation, je montre que la méthode de vraisemblance permet d'estimer les puissances en bande ou les paramètres cosmologiques à partir d'une carte ou d'un ensemble de pixels (étude des expériences COBE, MAX et Saskatoon).Ensuite, je décris les méthodes qui permettent d'utiliser les puissances en bandedes observations du CMB publiées dans la littérature pour déterminer les paramètres cosmologiques. Ces méthodes sont plus rapides que l'analyse de vraisemblance mais supposent différentes hypothèses sur lesquelles j'insiste. A partir des analyses de vraisemblance que j'ai effectuées, j'ai pu développé d'une part, uneméthode approximative quipermet de mieuxreproduire la forme de la fonction de vraisemblance, et d'autre part une nouvelle technique pour estimer la qualité d'ajustement des modèles préférés. Ces techniques ont été appliquées sur les données actuelles,incluant les plus récentes BOOMERANG et MAXIMA, pour déterminer les paramètres cosmologiques. Les conclusions sont présentées dans ce mémoire.Enfin, une dernière partie est dédiée à l'expérience ARCHEOPS, expérience ballon basée sur la technologie de Planck.

Douspis, Marian

2000-12-01

272

Preparation, biodistribution, and dosimetry of 188Re-Labeled MoAb ior cea1 and its f(ab?) 2 fragments by avidin-biotin strategy  

Microsoft Academic Search

The biotinylated monoclonal antibody (MoAb) ior cea1 and its F(ab?)2 fragments were labeled with Re-188 by combination of avidin-biotin strategy. 188Re-MoAb, 188Re-MoAb-biotin, 188Re-F(ab?)2, and 188Re-F(ab?)2-biotin preparations were produced for these studies with specific activities of 1.30 ± 0.18 GBq\\/mg and from instant freeze-dried kit formulations using ethane-1-hydroxy-1,1-diphosphonic acid (EHDP) as a weak competing ligand. There were no significant differences (p

Guillermina Ferro-Flores; Gilmara Pimentel-González; Mar??a Antonia González-Zavala; Consuelo Arteaga de Murphy; Laura Meléndez-Alafort; José I Tendilla; Barbara Y Croft

1999-01-01

273

Association of Neisseria gonorrhoeae Opa(CEA) with dendritic cells suppresses their ability to elicit an HIV-1-specific T cell memory response.  

PubMed

Infection with Neisseria gonorrhoeae (N. gonorrhoeae) can trigger an intense local inflammatory response at the site of infection, yet there is little specific immune response or development of immune memory. Gonococcal surface epitopes are known to undergo antigenic variation; however, this is unlikely to explain the weak immune response to infection since individuals can be re-infected by the same serotype. Previous studies have demonstrated that the colony opacity-associated (Opa) proteins on the N. gonorrhoeae surface can bind human carcinoembryonic antigen-related cellular adhesion molecule 1 (CEACAM1) on CD4? T cells to suppress T cell activation and proliferation. Interesting in this regard, N. gonorrhoeae infection is associated with impaired HIV-1 (human immunodeficiency virus type 1)-specific cytotoxic T-lymphocyte (CTL) responses and with transient increases in plasma viremia in HIV-1-infected patients, suggesting that N. gonorrhoeae may also subvert immune responses to co-pathogens. Since dendritic cells (DCs) are professional antigen presenting cells (APCs) that play a key role in the induction of an adaptive immune response, we investigated the effects of N. gonorrhoeae Opa proteins on human DC activation and function. While morphological changes reminiscent of DC maturation were evident upon N. gonorrhoeae infection, we observed a marked downregulation of DC maturation marker CD83 when the gonococci expressing CEACAM1-specific Opa(CEA), but not other Opa variants. Consistent with a gonococcal-induced defect in maturation, Opa(CEA) binding to CEACAM1 reduced the DCs' capacity to stimulate an allogeneic T cell proliferative response. Moreover, Opa(CEA)-expressing N. gonorrhoeae showed the potential to impair DC-dependent development of specific adaptive immunity, since infection with Opa(CEA)-positive gonococci suppressed the ability of DCs to stimulate HIV-1-specific memory CTL responses. These results reveal a novel mechanism to explain why infection of N. gonorrhoeae fails to trigger an effective specific immune response or develop immune memory, and may affect the potent synergy between gonorrhea and HIV-1 infection. PMID:23424672

Yu, Qigui; Chow, Edith M C; McCaw, Shannon E; Hu, Ningjie; Byrd, Daniel; Amet, Tohti; Hu, Sishun; Ostrowski, Mario A; Gray-Owen, Scott D

2013-02-12

274

76 FR 39842 - Draft Investigation Report-DuPont Belle; Public Comment Requested  

Federal Register 2010, 2011, 2012, 2013

...CHEMICAL SAFETY AND HAZARD INVESTIGATION BOARD Draft Investigation Report--DuPont Belle; Public Comment Requested In connection with its investigation into three incidents that occurred at the DuPont plant...

2011-07-07

275

76 FR 33401 - Environmental Impact Statement: Cook and DuPage Counties, Illinois  

Federal Register 2010, 2011, 2012, 2013

...Statement: Cook and DuPage Counties, Illinois AGENCIES: Federal Highway Administration...Bypass in Cook and DuPage Counties, Illinois. FOR FURTHER INFORMATION CONTACT: Norman...Executive Park Drive, Springfield, Illinois 62703, Phone: (217)...

2011-06-08

276

Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody  

PubMed Central

Background: Novel technologies to redirect T-cell killing against cancer cells are emerging. We hypothesised that metastatic human colorectal cancer (CRC) previously treated with conventional chemotherapy would be sensitive to T-cell killing mediated by carcinoembryonic antigen (CEA)/CD3-bispecific T-cell-engaging BiTE antibody (MEDI-565). Methods: We analysed proliferation and lysis of CEA-positive (CEA+) CRC specimens that had survived previous systemic chemotherapy and biologic therapy to determine whether they could be killed by patient T cells engaged by MEDI-565 in vitro. Results: At low concentrations (0.1–1?ng?ml?1), MEDI-565+ T cells caused reduced proliferation and enhanced apoptosis of CEA+ human CRC specimens. High levels of soluble CEA did not impair killing by redirected T cells and there was no increase in resistance to T-cell killing despite multiple rounds of exposure. Conclusions: This study shows for the first time that metastatic CRC specimens derived from patients previously treated with conventional chemotherapy can be lysed by patient T cells. Clinical testing of cancer immunotherapies, such as MEDI-565 that result in exposure of tumours to large numbers of T cells, is warranted.

Osada, T; Hsu, D; Hammond, S; Hobeika, A; Devi, G; Clay, T M; Lyerly, H K; Morse, M A

2009-01-01

277

The pregnancy-specific glycoprotein (PSG) gene cluster on human chromosome 19: Fine structure of the 11 PSG genes and identification of 6 new genes forming a third subgroup within the carcinoembryonic antigen (CEA) family  

SciTech Connect

The human pregnancy-specific glycoprotein (PSG) genes belong to the carcinoembryonic antigen (CEA) family, which in turn is a member of the immunoglobulin superfamily. We have analyzed a 700-kb cosmid contig spanning the PSG region on chromosome 19q13.2. The region contains 11 closely related PSG genes organized in tandem with a highly conserved structure and organization. Seven novel genes (CGM12 to CGM18) were found in the PSG region. CGM12 belongs to the CEA subgroup and appears to be a pseudogene. CGM13 to CGM18 forms a third new subgroup within the CEA gene family. The members of this new subgroup show 94-99% identity to each other but only 70-80% to other members of either the CEA or the PSG subgroups. They are composed of exons encoding two IgC-like domains and short hydrophilic carboxyl terminals similar to those of the PSGs. Unlike any of the known CEA family genes, however, they seem to lack the exon for an IgV-like N-terminal domain. 54 refs., 6 figs., 4 tabs.

Teglund, S.; Fraengsmyr, L.; Hammarstroem, S. [Univ. of Umea (Sweden)

1994-10-01

278

Physicochemical characterisation of depleted uranium (DU) particles at a UK firing test range  

Microsoft Academic Search

Depleted uranium (DU) particles were isolated from soils at Eskmeals, UK, where DU munitions have been tested against hard targets and unfired DU buried in soils for corrosion studies. Using electron microscopy and X-ray analyses, three classes of particles were identified: (1) DU aerosols and fragments, typically 1–20?m diameter, composed mainly of uranium as UO2 and U3O8, (2) solidified molten

Mustafa Sajih; Francis R. Livens; Rebeca Alvarez; Mathew Morgan

2010-01-01

279

Reconnaissance des Formes a L'aide DU Filtre de Phase D'harmoniques Circulaires  

Microsoft Academic Search

Cette these porte sur l'etude d'une nouvelle generation de filtres fabriques a partir de la phase du filtre d'harmoniques circulaires (FHC). Il s'agit du FHC de phase (FHCP), du FHC de phase binaire (FHCPB) et du FHC binaire (FHCB) qui, tout en etant invariants par rapport a la position et a l'orientation des cibles, offrent une meilleure capacite de discrimination

Luc Leclerc

1995-01-01

280

Etude expérimentale du comportement des tubes en acier remplis de béton  

Microsoft Academic Search

Une étude sur 27 essais de tube en acier remplis de béton a été effectuée. Les paramètres, résistance du béton, rapport diamètre sur épaisseur du tube et nuance d’acier sont traités. La relation charge déformation et la variation du volume dV\\/V ont montré qu’à partir de 70% de la charge ultime,?la déformation du composite se fait à volume croissant ce

B. Kebaili; B. Redjel

2012-01-01

281

Cri du chat syndrome: a critical review.  

PubMed

A new syndrome was identified in 1963, when Lejeune et al. reported a genetic disease resulting from a partial or total deletion on the short arm of chromosome 5 (5p-) and named it the cri du chat syndrome (CdCS). This term makes reference to the main clinical feature of the syndrome, a high-pitched monochromatic cat-like crying, that usually disappears in the first years of life. CdCS is one of the most common chromosomal deletion syndromes in humans, with an incidence of 1:15.000-1:50.000 live-births. Our purpose was to review different aspects of this syndrome (concept, epidemiology, aetiology, clinical features, diagnostic methods and prognosis) emphasizing both: the breakthrough in this field introduced by new cytogenetic and molecular techniques, and the orofacial manifestations most frequently reported. The main orofacial anomalies registered were mandibular microretrognathia, high palate but rarely cleft, variable malocclusion (frequently anterior open-bite), enamel hypoplasia, poor oral hygiene, generalized chronic periodontitis, and retardation of tooth eruption, although there is not enough evidence to support any clear association between these pathologies and the CdCS. PMID:20038906

Rodríguez-Caballero, Angela; Torres-Lagares, Daniel; Rodríguez-Pérez, Antonio; Serrera-Figallo, María-Angeles; Hernández-Guisado, José-María; Machuca-Portillo, Guillermo

2010-05-01

282

M.I.C.E. - NOUVEL ENJEU POUR LE DÉVELOPPEMENT DU TOURISME AU VIETNAM ?  

Microsoft Academic Search

Le Tourisme du Vietnam se développe et tente de s'intégrer au réseau régional et mondial. La concurrence devient de plus en plus serrée, et il faut répondre aux diverses demandes du marché. Ainsi apparait une nouvelle formule: le MICE. La définition de ce secteur, l'analyse SWOT du tourisme vietnamien, les expériences des autres pays apporteront au Vietnam un regard détaillé

VO SANG; Xuan Lan

283

76 FR 78974 - Wisconsin Central Ltd.-Abandonment Exemption-in Fond Du Lac County, WI  

Federal Register 2010, 2011, 2012, 2013

...Central Ltd.--Abandonment Exemption--in Fond Du Lac County, WI Wisconsin Central Ltd. (WCL) \\1\\ filed...line between mileposts 175.40 and 176.00, in Fond Du Lac, Fond Du Lac County, Wis. The line traverses United States...

2011-12-20

284

77 FR 2774 - Notice of Intent To Prepare a Supplemental Environmental Impact Statement: Fond du Lac...  

Federal Register 2010, 2011, 2012, 2013

...Environmental Impact Statement: Fond du Lac & Sheboygan Counties, WI AGENCY: Federal...Highway 151 to County Highway P in Fond du Lac and Sheboygan Counties, Wisconsin. FOR...S. Highway 151 in the City of Fond du Lac to County Highway P in the City of...

2012-01-19

285

Investissement En Incertitude Extension du Probleme de la Taille Optimale D'une Usine  

Microsoft Academic Search

Dans Cet Article, Nous Presentons un Probleme de Choix D'investissement En Incertitude. au Moment de Prendre Leurs Decisions, les Administrateurs Ne Connaissent Pas la Taille du Marche(Volume des Ventes) Mais Connaissent le Prix de Vente du Produit et la Distribution a Priori du Niveau des Ventes. Nous Comparons le Comportement des Entreprises Neutres au Risque a Celui des Entreprises Riscophobes.

G. Dionne; M. Pellerin

1987-01-01

286

Two-Generation Reproductive Toxicity Study of Implanted Depleted Uranium (DU) in CD Rats  

Microsoft Academic Search

Depleted uranium (DU) munitions and armor plating have been used in several conflicts over the last 17 yr, including the Persian Gulf War and the Iraq War. Because of its effectiveness and availability, DU will continue to be used in military applications into the foreseeable future. There is much controversy over the use of DU in weapons and equipment because

D. P. Arfsten; K. R. Still; E. R. Wilfong; E. W. Johnson; S. M. McInturf; J. S. Eggers; D. J. Schaeffer; M. Y.-V. Bekkedal

2009-01-01

287

Cultural Evolution and SETI  

Microsoft Academic Search

The Drake Equation for the number of radio communicative technological civilizations in the Galaxy encompasses three components of cosmic evolution: astronomical, biological and cultural. Of these three, cultural evolution totally dominates in terms of the rapidity of its effects. Yet, SETI scientists do not take cultural evolution into account, perhaps for understandable reasons, since cultural evolution is not well-understood even

S. J. Dick

2009-01-01

288

Evolution: rationalism versus creationism  

Microsoft Academic Search

The actual neo-Darwinian concepts of human evolution conceive this evolution as a bush, unpredictable and at random. At the beginning of the 20th century, most of the biologists conceived evolution as a linear process oriented to progress, even if Darwin already presented evolution as a bush. It is this point of view, of a process in one dimension, that some

Charles Susanne

2009-01-01

289

Is heterogeneous expression of HLA-dr antigens and CEA along with DNA-profile variations evidence of phenotypic instability and clonal proliferation in human large bowel carcinomas?  

PubMed Central

Epithelial expression of HLA-DR determinants and CEA was studied by immunofluorescence in tissue sections from 33 large bowel carcinomas of different histological grade and clinico-pathological stage; flow cytometric DNA measurements were performed in 31 of the tumours. Well-differentiated carcinomas showed a strikingly patchy staining, particularly for HLA-DR and all except one had a near-diploid DNA content. The latter feature might reflect cancer development at an early stage where no distinctly aneuploid DNA clone had as yet become a predominant subline. With decreasing degree of differentiation, the epithelial antigen expression became more homogeneous for individual tumours and the proportion of distinctly aneuploid DNA profiles increased. In the poorly differentiated group of carcinomas, epithelial staining was quite uniform, both for HLA-DR determinants and for CEA, and those tumours studied for DNA content were of the aneuploid variety. These observations are in agreement with the clonal proliferation theory of tumour development proposed by Nowell in 1976. Images Figure 1 Figure 2 Figure 3 Figure 4

Rognum, T. O.; Brandtzaeg, P.; Thorud, E.

1983-01-01

290

Radioimmunodetection of medullary thyroid cancer using a bispecific anti-CEA/anti-indium-DTPA antibody and an indium-111-labeled DTPA dimer.  

PubMed

Two-step radioimmunotargeting using a bispecific anti-CEA/anti-in-DTPA monoclonal antibody and an 111In-labeled DTPA dimer (diDTPA-TL) was evaluated nine times in eight patients with medullary thyroid cancer (MTC). Immunoscintigraphy was performed 5 and 24 hr after injection of 111In-diDTPA-TL. For five patients, radioimmunoguided surgery (RIGS) was performed using a hand-held gamma probe (sodium iodine), and a biodistribution study was performed 48 hr (four times) and 24 hr (one time) after injection of 111In-diDTPA-TL. Mean tumor uptake (%ID/kg in tumor) was 39 (range 2.75-139). In these five patients, immunoscintigraphy visualized all known tumors and detected unknown foci (US and CT were negative) in the neck (once) and neck and liver (once). Immunoscintigraphy, performed four times in search of a recurrence, detected unknown localizations in the mediastinum and neck (twice) and was negative twice. There were no false-positives. In three of five patients who had surgery, RIGS localized tumor foci not detected by the surgeon. RIGS failed to detect two small lesions (10 x 10 mm) corresponding to sites of fibrosis and microscopic cancer infiltration. Bispecific anti-CEA/anti-In-DTPA mediated targeting of 111In-diDTPA-TL provided elevated tumor uptake and tumor-to-normal tissue ratios. Radioimmunodetection of small MTC lesions is thus possible even when morphological imaging techniques prove negative. PMID:8326383

Peltier, P; Curtet, C; Chatal, J F; Le Doussal, J M; Daniel, G; Aillet, G; Gruaz-Guyon, A; Barbet, J; Delaage, M

1993-08-01

291

A collaborative study of a test for carcinoembryonic antigen (CEA) in the sera of patients with carcinoma of the colon and rectum  

PubMed Central

Five university centres in Canada and the United States have collaborated in a study of a test for carcinoembryonic antigen, with the Montreal General Hospital laboratory acting as the reference laboratory, examining duplicate halves of specimens from patients examined in local laboratories. Between June 1971 and April 1972, 503 patients were admitted to the study, 146 with cancer of the colon or rectum. Discrimination between colo-rectal cancer and “other” diagnoses was good at 2.5 ng./ml. or more, such a result being obtained in 66% of the patients with colo-rectal cancer in the local laboratories and 62% in the reference laboratory compared with 39% and 33% respectively of patients with “other” diagnoses. Patients with Duke's C lesions of the colon or rectum were more likely to have raised CEA levels than patients with more localized lesions. CEA was also more commonly found in patients with other cancers and in patients with liver disease than in patients with other (benign) diagnoses. It is concluded that the test can be reproduced in other laboratories and that it or another simplified technique could become an important diagnostic aid for colo-rectal cancer.

1972-01-01

292

Concordance between serum and cytosolic levels of CEA, CA125 and SCC antigens in patients with non-small cell lung cancer.  

PubMed

The relationship between serum and cytosolic levels of carcinoembryonic (CEA), squamous-cell carcinoma (SCC) and CA125 antigens was determined in 122 patients with non-small cell lung cancer. A pronounced serum-cytosol gradient and a high degree of dispersion in the distribution of serum and cytosol marker concentrations was detected. In addition, the degree of concordance between TM levels in the two compartments, determined by the intraclass correlation coefficient (ICC) index, was low (ICC = 0.42 for CEA; 0.35 for CA 125; and 0.27 for SCC). Tumour stage and histological type both played a limited role in the serum-cytosol relationship. As tumour stage advanced, the concordance between serum and cytosolic TM level became more pronounced. In addition, each histological type showed a distinctive pattern of expression of serum and cytosolic tumour markers, and a specific degree of concordance between levels in serum and cytosol. However, the ICC indices were always under 0.51, indicating that the importance of these factors is minor. The data obtained indicate that the relationship between serum and cytosolic concentration is moderate. The differences found according to stage grouping and histological subtype are so small that no clear-cut message for clinical practice can be drawn. PMID:8669870

Diez, M; Pollan, M; Maestro, M L; Ortega, M D; Gomez, A; Sanchez-Pernaute, A; Torres, A; Granell, J; Balibrea, J L

293

Les inconv?nients de perdre du poids  

PubMed Central

Résumé Objectif Explorer les raisons pour lesquelles la perte de poids à long terme échoue la plupart du temps et évaluer les conséquences de diverses trajectoires pondérales, y compris la stabilité, la perte et le gain. Source des données Les études qui évaluent les paramètres pondéraux dans la population sont en majorité observationnelles. Des données probantes de niveau I ont été publiées pour évaluer l’influence des interventions relatives au poids sur la mortalité et la qualité de vie. Message principal Seulement un petit pourcentage des personnes qui désirent perdre du poids réussissent à le faire de manière durable. La mortalité est la plus faible chez les personnes se situant dans la catégorie de poids élevé-normal et surpoids. La trajectoire pondérale la plus sécuritaire est la stabilité du poids avec une optimisation de la condition physique et métabolique. Il est démontré que la mortalité est plus faible chez les personnes ayant des comorbidités reliées à l’obésité si elles perdent du poids. Il est aussi établi que la qualité de vie sur le plan de la santé est meilleure chez les personnes obèses qui perdent du poids. Par contre, la perte de poids chez une personne obèse autrement en santé est associée à une mortalité accrue. Conclusion La perte de poids est recommandable seulement chez les personnes qui ont des comorbidités reliées à l’obésité. Les personnes obèses en santé qui veulent perdre du poids devraient être informées qu’il peut y avoir des risques à le faire. Une stratégie qui se traduit par un indice de masse corporelle stable avec une condition physique et métabolique optimisée, peu importe le poids, est l’option d’intervention la plus sécuritaire en ce qui concerne le poids.

Bosomworth, N. John

2012-01-01

294

Effets de L'anisotropie Cristalline et DU Desordre Controle Sur les Proprietes Optiques et Phononiques des Composes Semiconducteurs ZIRCONIUM(1-X) Hafnium(x) SOUFRE(3)  

NASA Astrophysics Data System (ADS)

Dans ce travail, nous presentons l'etude de l'effet de l'anisotropie cristalline et du desordre substitutionnel controle sur les proprietes electroniques et vibrationnelles des composes semiconducteurs Zr_{rm 1-x}Hf_{x} S_3. Les proprietes phononiques sont ete etudiees en spectroscopie Raman. Les mesures systematiques des spectres polarises de tous les composes nous ont permis d'identifier tous les phonons predits par la theorie des groupes et de suivre l'evolution de leur frequence avec la concentration de hafnium. L'analyse plus approfondie par un procede de lissage des spectres nous a permis detudier l'effet du desordre controle sur la largeur des modes phononiques. Les resultats de cette analyse ont ete confrontes aux predictions d'un modele developpe pour une chai ne diatomique desordonnee et ameliore suite a nos observations experimentales. La forme en cloche predite par ce dernier pour la variation de la largeur du mode optique de la chai ne est observee pour trois phonons de symetrie Bg. L'accord est excellent pour X > 0.5 pour deux des trois modes et ce, sans aucun parametre ajustable. Cette etude nous a permis, d'une part, de conclure que les modes Bg se comportent comme s'ils etaient sur une chai ne isolee et que, par consequent, les deux chai nes composant la cellule unite de nos cristaux sont tres faiblement liees et, d'autre part, de confirmer la symetrie des modes telle que deduite des spectres polarises. Les proprietes electroniques du ZrS_3 ont ete etudiees par des mesures polarisees du coefficient d'absorption pres de son gap indirect. L'evolution des spectres avec la temperature nous a permis d'identifier deux gaps paralleles differents et un gap perpendiculaire confirmant ainsi le modele de la structure de bande base sur les etats electroniques moleculaires de l'ion (S _2)^2. L'analyse detaillee des differentes structures du coefficient d'absorption indique clairement un caractere bidimensionnel du gap indirect. L'effet du desordre substitutionnel sur la structure de bande ainsi deduite pour ZrS_3 a ete etudie par des mesures de photoluminescence sur tous les composes. Un modele de l'intensite de la recombinaison radiative d'excitons localises dans les etats d'une queue de bande dans le gap des semiconducteurs decrit bien les raies observees dans les spectres des differents composes. Un procede de lissage nous a permis, d'une part, d'identifier deux polytypes du ZrS_3 correspondant aux deux variantes A et B de la structure cristallographique des composes MX_3 et, d'autre part, de deduire la variation avec la composition de l'energie des gaps parallele et perpendiculaire des deux polytypes.

Ait-Ouali, Abderrahmane

295

Bilan des cancers du col utérin diagnostiqués à l'Institut Pasteur de Madagascar de 1992 à 2002  

Microsoft Academic Search

RESUME : A Madagascar, les données épidémiologiques actualisées concernant le cancer du col utérin ne sont pas disponibles du fait de l'absence de registre du cancer. Le but de ce travail est de réaliser une première évaluation du problème, de compléter les connaissances épidémiologiques, de réfléchir sur les moyens de dépistage précoce des lésions précancéreu- ses, de proposer des mesures

Raharisolo Vololonantenaina CR; Rabarijaona LP; Soares JL; Rasendramino M; Pécarrère JL; Khun H; Huerre M

296

[Biography of the outstanding acupuncturist DU Xiao-shan].  

PubMed

Professor DU Xiao-shan 's academic thought and clinical experiences was introduced in this paper. He has noble medical ethics and is fair to the patients without distinction. He has great learning and rich practical experiences, and he specializes in all kinds of common diseases as well as many difficult and complicated cases. He never stops studying the ancients to make innovation and he creates the technique of the quick-puncture and slow-twist and DU's heat-reinforce method. He teaches to carry forward acupuncture and moxibustion and his achievements have become an important part of acupuncture and moxibustion science. PMID:23227700

Ding, Min; Lu, Rui-Qin; Du, Liang-Dong; Cao, Li; Lin, Tian-Yun

2012-09-01

297

Origine du champ magnétique en cosmologie et formation des galaxies  

NASA Astrophysics Data System (ADS)

Ma thèse est le fruit d'un travail théorique centré sur deux questions fondamentales de la cosmologie actuelle: la formation des galaxies d'une part, et l'origine des champs magnétiques à grande échelle d'autre part. Je propose une solution au problème du sur-refroidissement dont souffrent les modèles de formation des galaxies. Pour cela, à l'aide d'un modèle analytique simple, puis au moyen de simulations numériques, j'explore les mécanismes de transfert et de stockage d'énergie par ondes d'Alfvén en œuvre dans le milieu interstellaire (MIS) biphasique. Je montre d'une part que les interférences des ondes internes aux nuages du MIS, négligées dans les études précédentes, renforcent l'efficacité d'injection d'énergie. D'autre part, les mouvements des nuages redistribuent l'énergie à l'échelle du système entier. Ils injectent aussi de l'énergie dans les nuages. Les modes vibratoires internes excités s'opposent à la compression des nuages et prolongent la durée de vie du système. Les nuages magnétisés constituent alors un réservoir d'énergie sur plusieurs temps dynamiques. A l'aide d'un modèle de protogalaxie biphasique, je montre que la dynamique des nuages du MIS et celle d'une protogalaxie sont équivalentes. Pour résoudre le sur-refroidissement, je propose la transposition des résultats du MIS au cas protogalactique. Malgré les diverses tentatives passées, l'origine du champ magnétique en cosmologie n'a pas trouvé d'explication satisfaisante. Or, sa place au sein du MIS et son rôle dans la formation des galaxies sont manifestes. Je propose dans ma thèse un nouveau mécanisme de magnétogenèse efficace à grande échelle, opérant à la réionisation de l'Univers, et reposant sur la pression de radiation anisotrope et inhomogène fournie par les premières structures lumineuses. A l'échelle galactique, le champ magnétique que j'obtiens est huit ordres de grandeur plus intense que dans les modèles habituels. De plus, il est généré avant tout aux grandes échelles, les champs à petite échelle étant largement supprimés. Ces deux propriétés permettent au modèle proposé de rendre compte des champs observés dans les grandes structures.

Langer, Mathieu

2002-12-01

298

Cancer du col et VIH en afrique: une revue de la littérature  

Microsoft Academic Search

Résumé\\u000a Objectifs  Déterminer la prévalence du cancer du col chez les femmes séropositives au virus de l’immunodéficience humaine (VIH), décrire\\u000a les déterminants de l’association VIH et cancer du col et faire des recommandations par rapport au dépistage et à la prise\\u000a en charge du cancer du col chez ces patientes.\\u000a \\u000a \\u000a \\u000a Méthodologie  Nous avons procédé à une revue non systématique de la littérature

S. Ouattara; D. A. Some; M. Bambara; B. Dao

2009-01-01

299

Understanding Evolution: Welcome to Evolution 101!  

NSDL National Science Digital Library

Understanding Evolution, a project funded by the National Science Foundation and the Howard Hughes Medical Institute, teaches the science and history of evolutionary biology. This portion of the site, "Welcome to Evolution 101!" provides an excellent introduction for students to this topic. Sections include the basics of evolution, the history of life, how evolution works, microevolution, speciation, macroevolution and the big questions that evolutionary biologists are trying to answer. Each subsection of the site includes a self-guided tutorial complete with text and useful images. The site is also available in Spanish and Turkish.

2004-01-01

300

An alternative for cost-effective remediation of depleted uranium (DU) at certain environmental restoration sites  

SciTech Connect

Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon development programs, at firing practice ranges, or war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discreet, visually identifiable DU fragments mixed with native soil. That is, the bulk-averaged DU activity is quite low, while specific DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark, black metal that is nearly twice as dense as lead, but DU in the environment readily weathers to a distinctive bright yellow color that is readily visible. While the specific activity of DU is relatively low and presents only a minor radiological hazard, the fact that it is radioactive and visually identifiable makes it desirable to remove the DU contamination from the environment.

Miller, M.; Galloway, B.; VanDerpoel, G.; Johnson, E.; Copland, J.; Salazar, M.

2000-02-01

301

Application of biochemical markers CA 19-9, CEA and C-reactive protein in diagnosis of malicious and benign pancreatic tumors  

PubMed Central

Introduction We would save many lives and spare a lot of suffering if we could only detect and accurately determine the character and TMN staging of pancreatic tumors (PTs). With improved diagnosis, we could offer specific treatment that would result in better treatment outcome. The aim of study was to determine the significance of neoplastic markers CA 19-9 and CEA for prognosis in inflammatory and carcinomatous PTs. Material and methods We based our research upon a group of 170 patients. The patients were treated in our Oncologic Surgery Department from January 2007 to December 2010 for PTs. The patients were divided into four groups depending on the character of the tumor and underwent the following treatments: group 1 – 34 patients with carcinoma of the ampulla of Vater, group 2 – 64 patients with PTs at different stages (1, 2, 3) according to TMN classification, group 3 – 62 patients with PTs at stage 4 on the TMN scale (unresectable tumors), group 4 – 28 patients with inflammatory PTs. Results The results of Ca 19-9 in group 2 were 736.00 (25–75% 220.40–4285.00) ng/ml before surgery, 53.00 (25–75% 12.60–84.00) ng/ml in the 7 days after surgery, 29.4 (25–75% 7.90–113.00) ng/ml at day 30, and 119.00 (25–75% 96.30–621.00) ng/ml 3 months after the operation. These results were significantly higher than the control group but were significantly lower than the results for group 3 (unresectable tumors). The highest average concentration and median for CA 19-9 and CEA were noted in patients with unresectable PTs (the 3rd group). The average concentration for CEA was lowest in group 4, but much higher than the lab limits. Conclusions The sensitivity of the CA 19-9 marker may be as high as 88%. Values of CA 19-9 above 852 U/ml may indicate TNM stage 4, consistent with an unresectable PT. In the cases where CA 19-9 is within normal limits but C-reactive protein is above normal limits (often thirty times the upper limit), in comparison to the control group and to patients with pancreatic neoplasms, strong consideration should be given towards the inflammatory characteristics of the pancreatic changes and conservative treatment should be applied.

Piskorz, Lukasz; Wawrzycki, Marcin; Dobielski, Przemyslaw; Pikala, Malgorzata; Jablonski, Slawomir; Brocki, Marian

2013-01-01

302

Evolution of a tissue-specific splicing network  

PubMed Central

Alternative splicing of precursor mRNA (pre-mRNA) is a strategy employed by most eukaryotes to increase transcript and proteomic diversity. Many metazoan splicing factors are members of multigene families, with each member having different functions. How these highly related proteins evolve unique properties has been unclear. Here we characterize the evolution and function of a new Drosophila splicing factor, termed LS2 (Large Subunit 2), that arose from a gene duplication event of dU2AF50, the large subunit of the highly conserved heterodimeric general splicing factor U2AF (U2-associated factor). The quickly evolving LS2 gene has diverged from the splicing-promoting, ubiquitously expressed dU2AF50 such that it binds a markedly different RNA sequence, acts as a splicing repressor, and is preferentially expressed in testes. Target transcripts of LS2 are also enriched for performing testes-related functions. We therefore propose a path for the evolution of a new splicing factor in Drosophila that regulates specific pre-mRNAs and contributes to transcript diversity in a tissue-specific manner.

Taliaferro, J. Matthew; Alvarez, Nehemiah; Green, Richard E.; Blanchette, Marco; Rio, Donald C.

2011-01-01

303

Cost-Effective Remediation of Depleted Uranium (DU) at Environmental Restoration Sites  

SciTech Connect

Numerous sites in the United States and around the world are contaminated with depleted uranium (DU) in various forms. A prevalent form is fragmented DU originating from various scientific tests involving high explosives and DU during weapon-development programs, at firing practice ranges, or in war theaters where DU was used in armor-piercing projectiles. The contamination at these sites is typically very heterogeneous, with discrete, visually identifiable DU fragments mixed with native soil. The bulk-averaged DU activity is quite low, whereas DU fragments, which are distinct from the soil matrix, have much higher specific activity. DU is best known as a dark metal that is nearly twice as dense as lead, but DU in the environment readily weathers (oxidizes) to a distinctive bright yellow color that is quite visible. While the specific activity (amount of radioactivity per mass of soil) of DU is relatively low and presents only a minor radiological hazard, the fact that DU is radioactive and visually identifiable makes it desirable to remove the DU ''contamination'' from the environment. The typical approach to conducting this DU remediation is to use radiation-detection instruments to identify the contaminant and then to separate it from the adjacent soil, packaging it for disposal as radioactive waste. This process can be performed manually or by specialized, automated equipment. Alternatively, a more cost-effective approach might be simple mechanical or gravimetric separation of the DU fragments from the host soil matrix. At SNL/NM, both the automated and simple mechanical approaches have recently been employed. This paper discusses the pros/cons of the two approaches.

MILLER,MARK; GALLOWAY,ROBERT B.; VANDERPOEL,GLENN; JOHNSON,ED; COPLAND,JOHN; SALAZAR,MICHAEL

1999-11-03

304

Understanding Evolution: An Evolution Website for Teachers  

ERIC Educational Resources Information Center

|While many states are facing challenges to the teaching of evolution in their science classrooms, the University of California Museum of Paleontology, working with the National Center for Science Education, has developed a useful web-based resource for science teachers of all grade- and experience-levels. Understanding Evolution (UE) was…

Scotchmoor, Judy; Janulaw, Al

2005-01-01

305

Beobachtungen zum Mosaizismus beim Cri-du-chat-Syndrom  

Microsoft Academic Search

Two cases of the cri-du-chat-syndrome are described, one with mosaicism in regard to the deletion, the other with probable differences of the size of the deletion. In both cases there have been found a few cells, where the distal part of the short arm of a B-chromosome has been satellited.

Walter Sachsse; Edith Schmidt; Edeltrud Hellmich

1969-01-01

306

Zur klinischen Differentialdiagnose des Cri du Chat-Syndroms  

Microsoft Academic Search

The crying of one baby (girl) with a cri du chat-syndrome and another baby (boy) with a similar voice, but without the typical B-chromosome deficiency, were analysed by acoustic methods. The particular physical qualities of the voices were compared to those of normal infants.

H. J. Schroeder; E. Schleiermacher; T. M. Schroeder; H. Bauer; C. Richter; J. Schwenk

1967-01-01

307

Consonants in Cri du Chat Syndrome: A Case Study  

ERIC Educational Resources Information Center

This article reports on a longitudinal case study of consonant productions in one Norwegian girl with Cri du chat syndrome from age 4;6 to age 9;4. It was shown that she had many articulation errors throughout the period of observation. Furthermore, these errors were shown to fall into three main categories: (1) errors of differentiation and…

Kristoffersen, Kristian Emil

2008-01-01

308

Neurological abnormalities in the `cri-du-chat' syndrome 1  

Microsoft Academic Search

An unusual case of the cri-du-chat syndrome is described in a 6½ year old boy, who, as well as attacks of stridor and choking, showed disorders of spatial perception and cerebellar signs in the form of nystagmus, clumsiness of the hands, and ataxia. Pyramidal signs were also present. He was only mildly retarded mentally. Psychological testing showed that he had

Jack Colover; Mary Lucas; J. A. Comley; A. M. Roe

1972-01-01

309

Consonants in Cri du chat syndrome: A case study  

Microsoft Academic Search

This article reports on a longitudinal case study of consonant productions in one Norwegian girl with Cri du chat syndrome from age 4;6 to age 9;4. It was shown that she had many articulation errors throughout the period of observation. Furthermore, these errors were shown to fall into three main categories: (1) errors of differentiation and tuning, (2) errors of

Kristian Emil Kristoffersen

2008-01-01

310

Chromosomal Autoradiography in the Cri du Chat Syndrome  

Microsoft Academic Search

The pattern of DNA synthesis in the chromosomes of Group 4–5 has been analysed in cells from individuals with the cri du chat syndrome. The abnormal chromosome, a No. 5, is one of the pair characterized by relatively early completion of synthesis in the long arms. The two remaining members of this group, characterized by extensive late replication throughout their

J. German; J. Lejeune; M. N. Macintyre; J. De Grouchy

1964-01-01

311

"The Moon Ring": A Conversation with Randy DuBurke.  

ERIC Educational Resources Information Center

Discusses how the author, currently Editor-at-Large of Chronicle Books, chooses books to publish and discusses four attributes in a book that catch her eye. Presents an interview with Randy DuBurke and a conversation about his first picture book, "The Moon Ring." (SG)

Pearson, Susan

2003-01-01

312

College of DuPage Student Portrait, Fall Quarter 1999.  

ERIC Educational Resources Information Center

|The report profiles the College of DuPage's (COD) fall quarter 1999 student body. It presents a brief history of the college's enrollment and a comparison of enrollments with other Illinois community colleges. It also provides demographic information on current students. Additionally, enrollment information is included by program, division, and…

College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

313

DuPont Fluorochemical materials in TSV process  

Microsoft Academic Search

As a result of Montreal Protocol, CFCs included Freon TES and Genesolv DES in electronic assemblies cleaning as well as de-flux solvent for Surface Mounting Technology, SMT, in PCB industry has been banned for production. DuPont fluorochemical came up with the effective alternative, Vertrelreg, with zero ODP (Ozone Depletion Potential) as special fluids for cleaning and which also is proven

T. Lee

2008-01-01

314

College of DuPage Institutional Portrait, 1999-2000.  

ERIC Educational Resources Information Center

This report profiles the College of DuPage (Illinois) and provides a quick reference regarding the institution. It contains information on facilities and land, finance, staff, college/student services, the Library, athletics, academic calendars, maps, and instructional programs. This report reflects the college structure as of September 1999 and…

College of DuPage, Glen Ellyn, IL. Office of Research and Planning.

315

Fluctuations Internationales et Dynamique du Taux de Change  

Microsoft Academic Search

Cet article propose une revue de la littérature des MEGIS en économie ouverte. Le MEGIS international de base est incapable de rendre compte de la synchronisation cyclique des PIB observée dans les données, de la faible corrélation croisée des consommations et des fortes variations du taux de change. Ces énigmes empiriques ont donné lieu à une suite d'enrichissements théoriques visant

Jean-Olivier Hairault; Thepthida Sopraseuth

2008-01-01

316

Congo 1965-1999 : Les espoirs déçus du « Brésil africain »  

Microsoft Academic Search

L'économie de la République Démocratique du Congo est aujourd'hui bien plus pauvre qu'elle ne l'était à l'indépendance. La désorganisation de l'offre et l'érosion presque continue de la demande l'ont entraînée depuis les années 70 dans une spirale négative, provoquant l'informalisation de secteurs entiers, voire leur \\

Joseph Maton; Henri-Bernard Solignac Lecomte

2001-01-01

317

Tumeur du canal anal révélée par une fistule rectovaginale  

Microsoft Academic Search

\\u000a Résumé  La fistule rectovaginale (FRV) est une pathologie rare, une cause néoplasique en est exceptionnellement responsable. Nous\\u000a rapportons un cas de tumeur avancée du canal anal, révélée par une grosse FRV associée à de multiples fistules périnéales\\u000a externes.

M. Tamzaourte; I. Errabih; M. Fadlouallah; S. Tahri; H. Elkoundi; M. Lahmiri; H. Krami; H. Ouazzani

2010-01-01

318

La vie quotidienne des jeunes, du lycée au mariage  

Microsoft Academic Search

[fre] La vie quotidienne des jeunes du lycée au mariage . Olivier Galland et Pascal Garrigues . Naissance, apogée et déclin . Entre 1 5 et 30 ans, Les jeunes s'insèrent progressivement dans la vie adulte, et leurs activités quotidiennes portent la marque des étapes successives qu'ils accomplissent. Les lycéens travaillent beaucoup et sortent peu. Plus lycéens et pas encore

Olivier Galland; Pascal Garrigues

1989-01-01

319

University of Missouri research reactor DuPont success story  

SciTech Connect

The availability of adequate irradiation facilities for the production of radioisotopes essential to the medical and research product communities has become a major issue both domestically and worldwide. Facilities that had been available over the years have been forced to withdraw from routine production or have been permanently shut down for safety or cost considerations. This situation has in some cases resulted in there being a single source available for production of key isotopes critical to the nuclear medicine industry and the research product business, such as [sup 99]Mo and [sup 125]I. In the case of [sup 125]I, that single source did have unexpected production problems creating a worldwide shortage of this isotope for [approximately]6 months of 1991. This paper describes the relationship between DuPont and the University of Missouri Research Reactor initiated in 1978. In this relationship, target materials are sent to the reactor facility and irradiated according to schedules developed at DuPont. Irradiated capsules are sent back to DuPont on a weekly basis, where they are chemically processed, purified, and stocked for sale or sent to other DuPont manufacturing areas for labeled chemical production.

Marchetti, C.J. (E.I. Dupont, Bilerica, MA (United States))

1993-01-01

320

La gestion à court terme du portefeuille financier des ménages  

Microsoft Academic Search

[fre] La gestion à court terme du portefeuille financier des ménages . Les livrets d'épargne correspondent plutôt à une épargne- trésorerie : les ménages font autant de dépôts que de retraits. Les épargnants utilisent leur livret comme une sorte de compte-chèques rémunéré ou comme une réserve disponible en cas de coup dur. La moitié d'entre eux ne possèdent que ce

Françoise Dumontier

1996-01-01

321

The imperialist lens: Du Camp, Salzmann and early French photography  

Microsoft Academic Search

During the 1850s, the French government sponsored photographic missions to the Orient, the goal being to visually record and catalogue the monuments of Egypt, Palestine, Lebanon and Syria. The missions, however, also had a commercial side, as many of the photographers published their photographs as photographic albums, the Orient circulating as an academic tool and a consumable good. Maxime Du

Keri A. Berg

2008-01-01

322

Note de Synthèse des travaux de l'atelier Mobilité du Groupe de Prospective des Métiers et des Qualifications du Commissariat général du Plan  

Microsoft Academic Search

Le mode de gestion du travail qui reposait sur la grande entreprise industrielle employant à temps plein et à durée indéterminée un grand nombre de travailleurs qui faisaient carrière dans la même entreprise est en forte régression. Ce qui caractérise la gestion de la main d'œuvre aujourd'hui, c'est une diversification des modèles. Les trajectoires professionnelles des individus se caractérisent par

Fabienne Berton; Jean-François Germe

1999-01-01

323

Evolution de la norme du contrôle interne dans le contexte public local  

Microsoft Academic Search

(VF)Le contrôle interne public local connaît depuis quelques années une évolution tant conceptuelle que pratique. Notamment, il opère un transfert d’une logique de vérification et de surveillance, centrée sur les moyens prévus et consommés, vers une logique de maîtrise et d’évaluation des politiques publiques locales, aussi focalisée sur les objectifs, résultats et effets des actions engagées. À l’issue d’une synthèse

Julien Batac; David Carassus; Christophe Maurel

2009-01-01

324

Evolution and Probability.  

ERIC Educational Resources Information Center

|Some of the most impressive-sounding criticisms of the conventional theory of biological evolution involve probability. Presents a few examples of how probability should and should not be used in discussing evolution. (ASK)|

Bailey, David H.

2000-01-01

325

Oxygen and Biological Evolution.  

ERIC Educational Resources Information Center

|Discussed is the evolution of aerobic organisms from anaerobic organisms and the accompanying biochemistry that developed to motivate and enable this evolution. Uses of oxygen by aerobic organisms are described. (CW)|

Baugh, Mark A.

1990-01-01

326

Evolution of Transport Systems.  

National Technical Information Service (NTIS)

It is proposed that the evolution of transport catalysts for required nutrients may have preceded the evolution of biosynthetic pathways for these substances, or occurred at the same time as an alternative solution to the stress of nutrient depletion. If ...

J. T. Holden

1968-01-01

327

A comparison of iodine and indium labelled anti CEA intact antibody, F(ab)2 and Fab fragments by imaging tumour xenografts.  

PubMed

An intact anti CEA monoclonal antibody (C198) and its F(ab)2 and Fab fragments have been radiolabelled with 131I and 111In and their biodistributions and tumour imaging capabilities examined in mice with human tumour xenografts. 131I labelled F(ab)2 and Fab fragments showed improved tumour visualization compared with intact antibody, principally because of the more rapid whole body elimination of the radiolabel. Studies using 111In labelled fragments demonstrated that a major proportion (greater than 60%) of the administered radioactivity was retained in the kidneys and this was detrimental to tumour imaging in the mouse xenograft model. The present study emphasizes the importance of selecting the most appropriate combination of antibody preparation and radiolabel, and that the choice of radionuclide is influenced by both its physical and subsequent pharmacological characteristics. PMID:3350036

Andrew, S M; Perkins, A C; Pimm, M V; Baldwin, R W

1988-01-01

328

Systems assessment of water savings impact of controlled environment agriculture (CEA) utilizing wirelessly networked Sense•Decide•Act•Communicate (SDAC) systems.  

SciTech Connect

Reducing agricultural water use in arid regions while maintaining or improving economic productivity of the agriculture sector is a major challenge. Controlled environment agriculture (CEA, or, greenhouse agriculture) affords advantages in direct resource use (less land and water required) and productivity (i.e., much higher product yield and quality per unit of resources used) relative to conventional open-field practices. These advantages come at the price of higher operating complexity and costs per acre. The challenge is to implement and apply CEA such that the productivity and resource use advantages will sufficiently outweigh the higher operating costs to provide for overall benefit and viability. This project undertook an investigation of CEA for livestock forage production as a water-saving alternative to open-field forage production in arid regions. Forage production is a large consumer of fresh water in many arid regions of the world, including the southwestern U.S. and northern Mexico. With increasing competition among uses (agriculture, municipalities, industry, recreation, ecosystems, etc.) for limited fresh water supplies, agricultural practice alternatives that can potentially maintain or enhance productivity while reducing water use warrant consideration. The project established a pilot forage production greenhouse facility in southern New Mexico based on a relatively modest and passive (no active heating or cooling) system design pioneered in Chihuahua, Mexico. Experimental operations were initiated in August 2004 and carried over into early-FY05 to collect data and make initial assessments of operational and technical system performance, assess forage nutrition content and suitability for livestock, identify areas needing improvement, and make initial assessment of overall feasibility. The effort was supported through the joint leveraging of late-start FY04 LDRD funds and bundled CY2004 project funding from the New Mexico Small Business Technical Assistance program at Sandia. Despite lack of optimization with the project system, initial results show the dramatic water savings potential of hydroponic forage production compared with traditional irrigated open field practice. This project produced forage using only about 4.5% of the water required for equivalent open field production. Improved operation could bring water use to 2% or less. The hydroponic forage production system and process used in this project are labor intensive and not optimized for minimum water usage. Freshly harvested hydroponic forage has high moisture content that dilutes its nutritional value by requiring that livestock consume more of it to get the same nutritional content as conventional forage. In most other aspects the nutritional content compares well on a dry weight equivalent basis with other conventional forage. More work is needed to further explore and quantify the opportunities, limitations, and viability of this technique for broader use. Collection of greenhouse environmental data in this project was uniquely facilitated through the implementation and use of a self-organizing, wirelessly networked, multi-modal sensor system array with remote cell phone data link capability. Applications of wirelessly networked sensing with improved modeling/simulation and other Sandia technologies (e.g., advanced sensing and control, embedded reasoning, modeling and simulation, materials, robotics, etc.) can potentially contribute to significant improvement across a broad range of CEA applications.

Campbell, Jonathan T.; Baynes, Edward E., Jr.; Aguirre,Carlos (University of Texas at El Paso, El Paso, TX); Jordan, Jon (University of Arizona, Tucson, AZ); Giacomelli, Gene (University of Arizona, Tucson, AZ); Waggoner, Justin (New Mexico State University, Las Cruces, NM); Loest, Clint (New Mexico State University, Las Cruces, NM); Szumel, Leo; Nakaoka, Tyler; Pate, Ronald C.; Berry, Nina M.; Pohl, Phillip Isabio; Aguirre, Francisco Luis (Invernaderos y Maquinaria Aguirre, Cd., Aldama, Chihuahua, Mexico); Aguilar, Jose (University of Texas at El Paso, El Paso, TX); Gupta, Vipin P.; Ochoa, Juan (University of Texas at El Paso, El Paso, TX); Davis, Jesse Zehring; Ramos, Damian (University of Texas at El Paso, El Paso, TX)

2005-02-01

329

pi-Grammatical Evolution  

Microsoft Academic Search

\\u000a \\u000a ?Grammatical Evolution is presented and its performance on four benchmark problems is reported. ?Grammatical Evolution is a position-independent variation on Grammatical Evolution’s genotype-phenotype mapping process where\\u000a the order of derivation sequence steps are no longer applied to nonterminals in a predefined fashion from left to right on\\u000a the developing program. Instead the genome is used to specify which nonterminal will

Michael O’Neill; Anthony Brabazon; Miguel Nicolau; Sean Mcgarraghy; Peter Keenan

2004-01-01

330

Multi-modality treatment of primary nonresectable intrahepatic cholangiocarcinoma with /sup 131/I anti-CEA--a Radiation Therapy Oncology Group Study  

SciTech Connect

Thirty-seven patients with primary nonresectable intrahepatic cholangiocarcinoma (57% with prior treatment and/or metastasis) were prospectively treated with external radiation, chemotherapy, and /sup 131/I labelled anti-CEA. Therapy began in all trials with whole liver irradiation (21.0 Gy, 3.0 Gy/Fx, 4 days/week, 10 MV photons) with alternate treatment day chemotherapy (Adriamycin, 15 mg + 5-FU, 500 mg). One month after external beam therapy, chemotherapy was given (Adriamycin, 15 mg + 5-FU, 500 mg) followed the next day by the first administration of /sup 131/I anti-CEA. The treatment schedule used was 20 mCi day 0; 10 mCi day 5 as an outpatient. This schedule was derived from tumor dose estimates which indicated that 20 mCi (8-10 mCi/mg IgG) was sufficient to achieve tumor saturation with a tumor effective half-life of 3 to 5 days, depending upon the species of animal from which the antibody was obtained. The median tumor dose for the 20 mCi + 10 mCi regimen was 6.2 Gy. Antibody therapy was delivered in 2-month cycles using antibody generated in different species of animals; rabbit, pig, monkey, and bovine. Toxicity was limited to hematologic toxicity and was manifested as thrombocytopenia and leukocytopenia (3.2% Grade IV for each according to RTOG toxicity criteria). Tumor remission evaluated by CT scan digitized tumor volume analysis indicated a 26.6% partial response (PR). Tumor remission by physical examination indicated a 33.3% remission rate (25.9% PR and 7.4% complete remission (CR). The median survival for patients who responded was 15.2 months. The actuarial median survival for the entire group of patients (metastases and previous treatment) was 6.5 months. The longest partial remission is presently more than 4 years.

Stillwagon, G.B.; Order, S.E.; Klein, J.L.; Leichner, P.K.; Leibel, S.A.; Siegelman, S.S.; Fishman, E.K.; Ettinger, D.S.; Haulk, T.; Kopher, K.

1987-05-01

331

Arguing for Evolution.  

ERIC Educational Resources Information Center

|Discusses the Kansas State Board of Education's decision to remove references to evolution and cosmology from the state's education standards and assessment. Advocates the need to teach evolution in high schools for a meaningful biology education. Addresses the question whether the teaching of evolution poses a threat to Christianity or other…

Ayala, Francisco J.

2000-01-01

332

Evolution for Young Victorians  

NASA Astrophysics Data System (ADS)

Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's Origin of Species. Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented evolution in a non-Darwinian form amenable to religious interpretation.

Lightman, Bernard

2012-07-01

333

The evolution of vocabulary  

Microsoft Academic Search

Human language is unique among the communication systems of the natural world. The vocabulary of human language is unique in being both culturally transmitted and symbolic. In this paper I present an investigation into the factors involved in the evolution of such vocabulary systems. I investigate both the cultural evolution of vocabulary systems and the biological evolution of learning rules

Kenny Smith

2004-01-01

334

Evolution & Diversity in Plants.  

ERIC Educational Resources Information Center

Summarizes recent findings that help in understanding how evolution has brought about the diversity of plant life that presently exists. Discusses basic concepts of evolution, diversity and classification, the three-line hypothesis of plant evolution, the origin of fungi, and the geologic time table. Included are 31 references. (CW)

Pearson, Lorentz C.

1988-01-01

335

Persistent evidence of circulating tumor cells detected by means of RT-PCR for CEA mRNA predicts early relapse: A prospective study in node-negative breast cancer  

Microsoft Academic Search

BackgroundIn 100 consecutive patients with node-negative breast cancer who underwent curative surgery, we prospectively tested whether detection of circulating tumor cells in peripheral blood by means of reverse transcription-polymerase chain reaction for carcinoembryonic antigen (CEA) messenger RNA (mRNA) could predict patient outcomes.

Toko Jotsuka; Yasuhiro Okumura; Shogo Nakano; Hidetoshi Nitta; Takashi Sato; Masahiko Miyachi; Kazuyoshi Suzumura; Jun-ichi Yamashita

2004-01-01

336

Molecular detection of cancer cells in bone marrow and peripheral blood of patients with operable breast cancer. Comparison of CK19, MUC1 and CEA using RT-PCR.  

PubMed

We have compared three different RT-PCR procedures to measure cytokeratin 19 (CK19), carcinoembryonic antigen (CEA) and mucin MUC1 gene expression in order to determine their diagnostic value in detecting tumour cells in bone marrow aspirates of patients with operable breast cancer. In an experimental model, the best sensitivity was observed for CK19 and MUC1 RT-PCR assays, although only the CEA and CK19 assays showed good specificity. The study of 42 patients showed that a 'CK19 positive/CEA positive' RT-PCR assay in bone marrow correlated positively with a positive axillary lymph node status (N(0) versus N(1-3), P<0.05). Both assays were also positive in 17% of node negative patients. RT-PCR assays were more sensitive in bone marrow than in peripheral blood. Our results suggest that CK19 and CEA RT-PCR assays are powerful methods for detecting disseminated breast cancer cells. A larger study with long-term follow-up is required in order to clarify their clinical usefulness. PMID:10762743

Berois, N; Varangot, M; Aizen, B; Estrugo, R; Zarantonelli, L; Fernández, P; Krygier, G; Simonet, F; Barrios, E; Musé, I; Osinaga, E

2000-04-01

337

Interactive Evolution in the framework of Simulated Natural Evolution  

Microsoft Academic Search

This paper demonstrates how interactive evolution can be applied to the evolution of simulated natural evolution. Evolutionary algorithms of selection and variation by recombination and\\/or mutation can be used to simulate biological evolution in a computer. Interactive evolution can be used to direct the development of graphic models that are simulations of their counterparts in nature. Interactive evolution thus can

Jeanine Graf; Wolfgang Banzhaf

1996-01-01

338

Les figures du projet dans le système de santé du Québec (1967-2008): un défi à relever pour la politique des projets cliniques?  

Microsoft Academic Search

La plus récente politique d’organisation du système de santé du Québec se structure autour de la notion de projet. Néanmoins, la mise en œuvre de ces projets cliniques n’est pas uniquement une question de gestion de projet, mais renvoie aussi à une interrogation sur le sens que les acteurs de ces projets donnent au concept. En effet, nous montrons ici

Ronan Hério; Jacques-Bernard Gauthier

2011-01-01

339

Limited Recall Of DuMOR' Poultry Grower/Finisher Bags Containing DuMOR' Poultry Layer 16% Crumbles Because of Possible Animal Health Risk  

NASA Website

Feed Solutions is voluntarily recalling a single lot of DuMOR® Poultry Layer 16% Crumbles, which was incorrectly packaged and shipped in DuMOR® Poultry Grower/Finisher bags. The incorrectly packaged feed, while appropriate for layers, can be ...

340

Influence du peuplement forestier sur la faune et la microflore du sol et des humus. II. Microbologie et expériences au laboratoire  

Microsoft Academic Search

Cet article suit un article précédemment paru dans le dernier fascicule de cette revue, qui concernait la description des sites et la présentation des principaux résultats relatifs à la faune du sol. Cette étude a été accomplie dans le cadre du projet PIREN-CNRS «Influence des monocultures de résineux et alternatives possibles». Trois stations permanentes ont été étudiées: un peuplement de

P. Arpin; J. F. David; G. G. Guittonneau; G. Kilbertus; J. F. Ponge; G. Vannier

1986-01-01

341

Understanding Evolution for Teachers  

NSDL National Science Digital Library

This site provides information and resources for educators on learning about and teaching evolution. Topics include the basic science and mechanisms of evolution, evidence to support the theory, potential impacts of evolutionary science, the history of the theory, and some common misconceptions about it. The teaching section provides a database of lesson plans and other resources, suggestions for overcoming roadblocks to the teaching of evolution, and suggestions for avoiding possible pitfalls in creating confusion or wrong impressions. There are also links to additional resources arranged by topic: explanations and mechanisms of evolution; relevance of evolutionary theory in daily life; lines of scientific evidence supporting evolution; and the history of evolutionary theory.

342

Caractérisation du seuil de dommage dans les cristaux de saphir dopé au titane avec des impulsions de durée nanoseconde, picoseconde et femtoseconde  

NASA Astrophysics Data System (ADS)

Le verrou principal pour le développement des systèmes femtoseconde robustes et rentables est l'incertitude du seuil de dommages du cristal de Ti: Saphir. Nous avons d'abord caractérisé le seuil diélectrique de dommages du Ti : Saphir.

Canova, F.; Chambaret, J.-P.; Mourou, G.; Sentis, M.; Uteza, O.; Delaporte, P.

2006-12-01

343

AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment.  

PubMed

The palliative therapy effect by docetaxel for CRPC patients makes it urgent to improve the therapy. It was suggested that PI3K and androgen receptor-directed combination therapy may be effective for prostate cancer (PCa) patients PTEN negative. However, for those patients PTEN positive, the mechanism of anti-apoptosis survival of cancer cells is not yet well defined. Amplification of AURKA has been detected in 5% of PCa. In this work, Du145, a PTEN positive PCa cell model, was employed to investigate the role of aurora kinase a (AURKA) on cell growth. Inhibition of AURKA expression by shRNA markedly reduced prostate cancer cell viability. Furthermore, we demonstrate that AURKA inhibition induced a remarkable downregulation of AKT activity and Bax induction. Moreover, specific inhibition of the activity of AURKA, but not other aurora family members, by small molecular chemical inhibitors induced significant cell killing effects. Notably, AURKA inhibition sensitized prostate cancer cells to docetaxel treatment. Our work suggests that AURKA-directed monotherapy or combination therapy with docetaxel could be a potent treatment for PCa patients in future. PMID:23634246

He, Wei; Zhang, Min-Guang; Wang, Xiao-Jing; Zhong, Shan; Shao, Yuan; Zhu, Yu; Shen, Zhou-Jun

2013-04-19

344

AURKA suppression induces DU145 apoptosis and sensitizes DU145 to docetaxel treatment  

PubMed Central

The palliative therapy effect by docetaxel for CRPC patients makes it urgent to improve the therapy. It was suggested that PI3K and androgen receptor-directed combination therapy may be effective for prostate cancer (PCa) patients PTEN negative. However, for those patients PTEN positive, the mechanism of anti-apoptosis survival of cancer cells is not yet well defined. Amplification of AURKA has been detected in 5% of PCa. In this work, Du145, a PTEN positive PCa cell model, was employed to investigate the role of aurora kinase a (AURKA) on cell growth. Inhibition of AURKA expression by shRNA markedly reduced prostate cancer cell viability. Furthermore, we demonstrate that AURKA inhibition induced a remarkable downregulation of AKT activity and Bax induction. Moreover, specific inhibition of the activity of AURKA, but not other aurora family members, by small molecular chemical inhibitors induced significant cell killing effects. Notably, AURKA inhibition sensitized prostate cancer cells to docetaxel treatment. Our work suggests that AURKA-directed monotherapy or combination therapy with docetaxel could be a potent treatment for PCa patients in future.

He, Wei; Zhang, Min-Guang; Wang, Xiao-Jing; Zhong, Shan; Shao, Yuan; Zhu, Yu; Shen, Zhou-Jun

2013-01-01

345

Has Human Evolution Stopped?  

PubMed Central

It has been argued that human evolution has stopped because humans now adapt to their environment via cultural evolution and not biological evolution. However, all organisms adapt to their environment, and humans are no exception. Culture defines much of the human environment, so cultural evolution has actually led to adaptive evolution in humans. Examples are given to illustrate the rapid pace of adaptive evolution in response to cultural innovations. These adaptive responses have important implications for infectious diseases, Mendelian genetic diseases, and systemic diseases in current human populations. Moreover, evolution proceeds by mechanisms other than natural selection. The recent growth in human population size has greatly increased the reservoir of mutational variants in the human gene pool, thereby enhancing the potential for human evolution. The increase in human population size coupled with our increased capacity to move across the globe has induced a rapid and ongoing evolutionary shift in how genetic variation is distributed within and among local human populations. In particular, genetic differences between human populations are rapidly diminishing and individual heterozygosity is increasing, with beneficial health effects. Finally, even when cultural evolution eliminates selection on a trait, the trait can still evolve due to natural selection on other traits. Our traits are not isolated, independent units, but rather are integrated into a functional whole, so selection on one trait can cause evolution to occur on another trait, sometimes with mildly maladaptive consequences.

Templeton, Alan R.

2010-01-01

346

Combined administration of duloxetine (DU) and lorazepam (LO): A pharmacokinetic (PK) and pharmacodynamic (PD) study  

Microsoft Academic Search

Background\\/Aims: DU is a relatively balanced and potent dual inhibitor of norepinephrine and serotonin transporters, indicated for depression and targeted for female stress urinary incontinence. To assess possible DU-LO interaction, a randomized, double-blind, two-period, crossover study was conducted in 16 healthy subjects.Methods: DU (60mg BID) or placebo was given for 8 days; LO (2 mg BID) was given from Day

S. Chalon; F. Vandenhende; S. Ertle

2005-01-01

347

Long-term corrosion and leaching of depleted uranium (DU) in soil  

Microsoft Academic Search

Corrosion and leaching of depleted uranium (DU) was investigated for 3 years using six DU munitions (145–264 g DU) each buried\\u000a in a column with a soil core of about 3.3 kg dry soil mass. The columns were installed in an air-conditioned laboratory. Each\\u000a week they were irrigated and 238U was determined in the effluents by inductively coupled plasma mass spectrometry. In addition,

W. Schimmack; U. Gerstmann; W. Schultz; G. Geipel

2007-01-01

348

Degradation du bien-etre economique des immigrants et causes possibles : mise a jour 2005  

Microsoft Academic Search

Il est question dans ce document de l'accentuation de l'ecart de gains entre les immigrants et les Canadiens de souche depuis deux decennies, et des explications actuelles de cette deterioration du marche du travail parmi les immigrants recents en particulier. Le document fait etat egalement de l'ecart grandissant du taux de faible revenu entre les immigrants et les non-immigrants. Tout

Garnett Sweetman Arthur Picot

2005-01-01

349

La formation du taux d'intérêt et le marché des crédits bancaires français  

Microsoft Academic Search

[fre] Cet article développe et teste économétriquement un modèle du marché des crédits bancaires français afin d'analyser les facteurs déterminant les variations du taux de l'intérêt. Le modèle établit des hypothèses quant à l'offre et à la demande da prêts bancaires et introduit l'influence des instruments de la politique monétaire et budgétaire sur le comportement des banques et du public

André Fourcans

1975-01-01

350

Notes sur l'écologie et l'éthologie des espèces du genre Lasius (Hymenoptera Formicid?)  

Microsoft Academic Search

Résumé L'observation de l'emplacement et du mode de nidification des espèces du genreLasius dans leur milieu naturel a permis de mettre en évidence des exigences écologiques bien définies. De même, la complexité des techniques mises en ?uvre et le type de matérian employé lors de la construction des nids permettent de présenter un classement des mœurs des espèces du genreLasius.

Ch. Gaspar

1965-01-01

351

Culture à l’hôpital: une signalétique Art Nouveau au service du patient  

Microsoft Academic Search

Résumé  La démarche artistique dans un environnement des soins « induit des différences dans les résultats cliniques, réduit la quantité\\u000a de drogues consommées, raccourcit la durée du séjour à l’hôpital, améliore la prise en charge du patient, contribue à la satisfaction\\u000a professionnelle et améliore la qualité du service », comme le prouve une étude menée par le Chelsea Westminster Hospital de

Cédric Bouquet; Fabrice Gillet

2010-01-01

352

Planification sociale et modèles économétriques : quelques réflexions après la préparation du VIIIe Plan  

Microsoft Academic Search

[fre] Trois des six priorités du VIIIe Plan concernent les aspects sociaux du dévelop­pement : emploi, protection sociale (sécurité sociale, santé, retraites, politiques familiales, action sociale) et habitat. Des simulations réalisées grâce au modèle macroéconomique DMS ont facilité l'analyse des relations entre le développement économique et la politique sociale. Elles ont montré comment des réduc­tions de durée du travail, des

Bernard Brunhes

1980-01-01

353

Une tumeur exceptionnelle du doigt: la tumeur fibreuse solitaire  

PubMed Central

La tumeur Fibreuse solitaire (TFS) est une prolifération fusocellulaire rare, souvent de localisation intra-thoracique. Nous rapportons le cas d'une localisation exceptionnelle au niveau du 3ème doigt de la main droite. En l'absence de marqueur spécifique l'interprétation de l'immuno-marquage dépend du contexte histo-morphologique. La similitude avec les différents néoplasmes à cellules fusiformes des tissus mous rend le diagnostic de ces tumeurs mésenchymateuses difficile et tardif. Dans 20à 30% des cas le comportement de la TFS est celui d'une tumeur maligne localement agressive et récidivante, avec des métastases rares et tardives. Ce comportement impose une surveillance prolongée après exérèse chirurgicale.

Harmouch, Taoufiq; Hamas, Nawal; Daoudi, Abdelkrim; Amarti, Afaf

2011-01-01

354

A Conversation with Lee Alvin DuBridge - Part I  

NASA Astrophysics Data System (ADS)

Physicist Lee A. DuBridge became president of the California Institute of Technology in 1946. In this interview he recalls the immediate problems he faced, including his dealings with Robert A. Millikan, whom he replaced as chief administrator of the institute; institute financing and inadequate salaries. DuBridge also talks about the advent of federal support for peacetime science and Millikan's distaste for it; his close working relationship with Robert F. Bacher, who came to the institute in 1949 as chairman of the Division of Physics, Mathematics, and Astronomy; his recollections of the meteorologist Irving P. Krick, the physicist Alexander Goetz, and the chemist Linus Pauling; and his attempts to build up the Humanities Division.

Goodstein, Judith R.

355

Le syndrome de Cri du Chat : A propos d'une observation  

PubMed Central

Le syndrome du Cri du Chat (Cri du Chat syndrome, CdCS) est une anomalie chromosomique résultant d’une délétion de taille variable de l’extrémité du bras court du chromosome 5 (5p), incluant une région critique située en p15.2. Il représente une des délétions chromosomiques les plus fréquentes, son incidence dans la population générale est de 1/20 000 à 1/50 000. Les caractéristiques cliniques comprennent un cri monochromatique aigu, une microcéphalie, une dysmorphie cranio-faciale caractéristique évoluant avec l’âge et un retard mental et psychomoteur important. La taille de la délétion est variable, Le traitement est fonction des différents symptômes. Un remaniement chromosomique parental est retrouvé dans 12% des cas et la majorité des délétions responsables de la maladie du cri-du-chat surviennent de novo. Nous présentons une observation d’un syndrome du Cri du Chat, confirmé par caryotype métaphasique (46,XY,del(5)(p13) de novo). A travers cette observation nous mettrons à jour, les actualités scientifiques de ce rare syndrome, ainsi que la place des explorations cytogénétiques dans le diagnostic précis et le conseil génétique des syndromes dysmorphiques.

Ouldim, Karim; Samri, Imane; Bouguenouch, Laila; Hamdaoui, Hasna; Otmani, Ihsan El; Hbibi, Mohamed; Chaouki, Sana; Hida, Moustapha

2012-01-01

356

Carcinome neuroendocrine du sein: ? propos d'un cas et revue de la litt?rature  

PubMed Central

Le carcinome neuroendocrine primitif du sein est une tumeur rare qui a été reconnue par la dernière édition de la classification OMS du cancer du sein publiée en 2003. Le diagnostic est évoqué sur des critères morphologiques et confirmé par l'expression des marqueurs neuroendocrines (chromogranine et synaptophysine) par plus de 50% des cellules tumorales. Nous rapportons un nouveau cas de carcinome neuroendocrine primitif du sein, et à travers une revue de la littérature, nous détaillons les aspects épidémiologiques, morphologiques et immuno-histochimiques de cette tumeur rare.

El Fatemi, Hinde; Hammas, Nawal; Moumna, Kaoutar; Bedahou, Mouhcine; Mellas, Nawfel; Mesbahi, Omar

2012-01-01

357

Cri-du-chat Syndrome: A Topical Overview  

Microsoft Academic Search

Cri-du-chat syndrome (CDCS) refers to a unique combination of physical and mental characteristics associated with a loss of genetic material on the distal short arm of the fifth chromosome. Also called 5p- syndrome, 5p monosomy, or Cat Cry syndrome it was first identified by Dr. Jerome Lejeune in 1963, and so named because of the distinctive cry in infancy that

Dennis J. Campbell; Mary Ester Carlin; Joseph E. Justen; Samera M. Baird

358

Les dimensions de l'organisation du travail  

Microsoft Academic Search

[fre] Dans l'organisation du travail, les cadres et professions intermédiaires s'opposent aux exécutants, ouvriers et employés, par le pouvoir qu'ils exercent sur leur propre travail et sur celui des autres, mais aussi par leur réseau de communications. Celles-ci sont plus variées, plus riches et de plus longue portée pour les cadres que pour les exécutants. Les cadres disposent aussi de

Michel Gollac

1989-01-01

359

L'or dans la métallogenie du massif de Bohême  

Microsoft Academic Search

Résumé  Les minéralisations aurifères du massif de Bohême sont représentées par plusieurs types morphologiques et paragénétiques,\\u000a dont l'origine est expliquée par trois modèles genétiques: I — un modèle volcanogénique pour les minéralisations sulfurés\\u000a stratiformes, II — un modèle hydrothermal-métamorphique pour les minéralisations de quartz aurifères synmétamorphiques, de\\u000a morphologie très variable et caractérisées par la présence de minéraux de Bi, Te, Mo

P. Morávek; Z. Pouba

1990-01-01

360

Politique des déchets : l'approche du Royaume-Uni  

Microsoft Academic Search

[fre] Politique des déchets : l'approche du Royaume-Uni . L'évolution récente de la réglementation européenne en dématière de déchets risque d'entraîner des coûts importants pour les États membres. L'exemple britannique est d'autant plus intéressant pour la France que les deux pays présentent des similitudes : quantité presque identique de déchets ménagers (environ 20 millions de tonnes), faible capacité des incinérateurs

David Litvan

1995-01-01

361

Portrait des musiciens à l'heure du numérique  

Microsoft Academic Search

L’industrie musicale est en crise alors que dans le même temps la consommation de musique ne s’est jamais aussi bien portée. Ces difficultés ont conduit à des politiques publiques défensives, concentrées sur la protection de la filière musicale contre le piratage. Pourtant l’impact du numérique est bien plus large. Les opportunités qu’il offre devraient, au contraire, conduire à des politiques

Maya Bacache-Beauvallet; Marc Bourreau; François Moreau

362

Effets in vitro des dermaseptines sur les caractéristiques du sperme  

Microsoft Academic Search

Resume  Au cours de ce travail et dans le cadre stratégique du développement des molécules multiactives et plurifonctionnelles, nous\\u000a nous sommes proposés de tester pour la première fois les dermaseptines (DS), peptides de vertébrés biologiquement actifs,\\u000a en tant que spermicide.\\u000a \\u000a Nous avons étudiéin vitro l’activité de ces nouvelles structures peptidiques, sur la mobilité et la viabilité des spermatozoïdes humains et avons

Mounir Ajina; Amira Zairi; Soumaya Mougou; Samira Ibalaa; Radhouène Naiefer; Ghaya Merdassi; Mariem Mehdi; Khaled El Heni; Ali Saad

2005-01-01

363

Wheat Evolution: Dough Washing  

NSDL National Science Digital Library

In this activity (page 5), learners investigate the evolution of wheat by washing different types of dough with water and comparing the results. The evolution of wheat from wild grasses demonstrates the dramatic effect of both natural and directed evolution on the structure of a crop plant and the chemical makeup of the product harvested from it. These activities illustrate the changes to both the structure and the chemistry of the wheat plant.

Council, Biotechnology A.

2012-01-01

364

SSE: Single Star Evolution  

NASA Astrophysics Data System (ADS)

SSE is a rapid single-star evolution (SSE) code; these analytical formulae cover all phases of evolution from the zero-age main-sequence up to and including remnant phases. It is valid for masses in the range 0.1-100 Msun and metallicity can be varied. The SSE package contains a prescription for mass loss by stellar winds. It also follows the evolution of rotational angular momentum for the star.

Hurley, Jarrod R.; Pols, Onno R.; Tout, Christopher A.

2013-03-01

365

Mucins CA 125, CA 19.9, CA 15.3 and TAG-72.3 as tumor markers in patients with lung cancer: comparison with CYFRA 21-1, CEA, SCC and NSE.  

PubMed

Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients]. In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9 (6.2%); CA 125 (28.7%); NSE (0.7%); CYFRA (8.7%); TAG-72.3 (4.2%); SCC (3.5%), and CA 15.3 (3.5%). Excluding patients with renal failure or liver diseases, tumor marker specificity improved with abnormal levels in 0.5% for NSE, 0.9% for SCC, 2.8% for CEA, CA 15.3 and TAG-72.3, 3.8% for CA 19.9, 4.2% for CYFRA and 21.4% for CA 125. Excluding CA 125, one of the markers was abnormal in 15% of patients without malignancy. Tumor marker sensitivity was related to cancer histology and tumor extension. NSE had the highest sensitivity in SCLC and CYFRA and CEA in NSCLC. Significantly higher concentrations of CEA, SCC, CA 125, CA 15.3 and TAG-72.3 were found in NSCLC than in SCLC. Likewise, significantly higher CEA (p < 0.0001), TAG-72.3 (p < 0.001), CA 15.3 (p < 0.0001) and CA 125 (p < 0.01) were found in adenocarcinomas than in squamous tumors. Using a combination of 3 tumor markers (CEA, CYFRA 21-1 in all histologies, SCC in squamous tumors and CA 15.3 in adenocarcinomas), a high sensitivity may be achieved in all histological types. Tumor markers may be useful in the histological differentiation of NSCLC and SCLC. Using specific criteria for the differentiation of SCLC and NSCLC, the sensitivity was 84.2 and 68.8%, the specificity was 93.8 and 99.7%, the positive predictive value was 98.3 and 98.5% and the negative predictive value was 57.7 and 93.3%, respectively. PMID:19060513

Molina, Rafael; Auge, Jose Maria; Escudero, Jose Miguel; Marrades, Ramon; Viñolas, Nuria; Carcereny, Emilio; Ramirez, Jose; Filella, Xavier

2008-12-08

366

Clinical evaluation of two new bifunctional chelating agents for immunoscintigraphy (I.S.) with indium-111-anti-CEA monoclonal antibody  

SciTech Connect

Previous animal studies have shown that chelates of In-111 with semi-rigid cyclohexyl EDTA (CDTA) derivatives produce improved in-vivo stability compared to non-rigid analogs. Two CDTA derivatives, CDTA-EN-SCN (dilithium salt of N-(methyl (2-isothiocyanato-ethyl) carbamide) trans-1,2-diaminocyclohexane N,N{prime},N{prime}-triacetic acid) and 4-ICE (4-isothiocyanato-trans-1,2-diaminocyclohexane-N,N,N {prime},N{prime}-tetraacetic acid), were synthesized, coupled to anti-CEA F(ab{prime}){sub 2} fragments and labeled with In-111 with a specific activity of 111MBq/mg. Five patients were injected with CDTA-EN-SCN and 4 with 4-ICE. IS was performed 3 days after injection. Mean blood activity, at the time of IS, expressed as the percentage of injected dose per ml, was 0.0038% with 4-ICE and 0.0071% with CDTA-EN-SCN. For comparative purposes, the mean value previously obtained with DTPA coupled to the same antibody was 0.0035%. Liver uptake was estimated from semi-quantitative calculations on scintigraphic images. Compared with the value obtained in a patient injected with 72.3 antibody coupled to DTFPA, a 2.5-fold reduction in liver uptake was observed. However, this reduction was sufficient to allow visualization of a large liver metastasis in one patient. With CDTA-EN-SCN, colon activity was moderate in 3 patients and intense in 1. With 4-ICE it was moderate in 2 patients and intense in 1, With CDTA-EN-SCN, true-positive IS results were observed in 2 patients (pelvis and mediastinum) and a false-negative result was observed in 1 patient (pelvis). In 3 patients, IS was negative and recurrence not yet confirmed despite high serum CEA level. With 4-FICE, true-positive IS results were observed in 3 patients (2 pelvis, 1 lung). A false-negative result was found in a patient with a confirmed liver metastasis.

Chatal, J.F.; Gestin, J.F.; Faivre-Chauvet, A. [Brookhaven National Lab., Upton, NY (United States)] [and others

1994-05-01

367

Rapport sur l'état du patrimoine astronomique dans les observatoires français de la fin du XIXè siècle  

NASA Astrophysics Data System (ADS)

Suite au colloque sur la sauvegarde du patrimoine astronomique organisé par le MAEE et la SAF, sous l'égide de l'UNESCO, qui a conduit à l'adoption de la Déclaration de Paris, les directeurs d'observatoires institutionnels qui étaient absents du colloque ont ressenti le besoin de discuter de ces conclusions prises en leur nom. L'initiative d'organiser une réunion des directeurs des Observatoires des Sciences de l'Univers (OSU) à ce sujet le 30 janvier 2012 a été prise par François Vernotte, directeur de l'Observatoire de Besançon. Le présent compte-rendu de visite résulte d'une initiative spontanée d'Emmanuel Pécontal, astronome responsable du Patrimoine à l'observatoire de Lyon, et d'Evelyne Damm, membre de la Commission Nationale de classement des Monuments Historiques (CNMH) et élue à la communauté d'agglomération des Portes de l'Essonne oû est sis l'observatoire de Camille Flammarion.

Damm, E.; Pécontal, E.

2012-12-01

368

Étude de la part du paludisme chez les consultants fébriles et des indices plasmodiques chez des écoliers dans la région du Trarza, République islamique de Mauritanie  

Microsoft Academic Search

Résumé  Afin d’apprécier l’importance du paludisme dans la basse vallée du fleuve Sénégal, nous avons étudié l’incidence du paludisme\\u000a chez les patients consultant pour un paludisme présomptif à l’hôpital régional de Rosso. L’endémicité palustre a été également\\u000a mesurée chez des écoliers à différentes périodes. Au total, 1 431 prélèvements (gouttes épaisses [GE] et frottis sanguins\\u000a [FS]) ont été effectués chez des

M. Ouldabdallahi; M. Ouldbezeid; M. Dieye; B. Yacine; O. Faye

369

Les traces matérielles de la Carte du Ciel. Le cas des observatoires d'Alger et de Bordeaux.  

NASA Astrophysics Data System (ADS)

Le chapitre évoque les traces matérielles de la Carte du ciel subsistant dans les observatoires d'Alger et de Bordeaux. Les auteurs examinent d'abord l'opération d'inventaire du patrimoine astronomique entreprise à partir du milieu des années 1990. Ils examinent ensuite les éléments concrets constituant aujourd'hui le patrimoine de la Carte du Ciel : lunettes, abris, accessoires, laboratoires, réseaux, plaques de verre, registres, machines à mesurer les clichés, et cartes.

Le Guet Tully, F.; Davoigneau, J.; Lamy, J.; de La Noë, J.; Rousseau, J.-M.; Sadsaoud, H.

2008-06-01

370

Etude préliminaire de l’activité du Syngel® dans le traitement symptomatique de la dysphagie post-radique  

Microsoft Academic Search

Résumé  Le but de cette étude non contrôlée est de vérifier l’efficacité, la tolérance et les effets secondaires du Syngel® dans le\\u000a traitement de la dysphagie post-radique.\\u000a \\u000a Soixante patients ont reçu du Syngel® soit préventivement (n = 21), soit lors de l’apparition des symptômes (n = 39). Au total,\\u000a 66 % des patients du groupe préventif et 74 % du groupe

C. Kirkove; F. Richard; A. Wambersie

1996-01-01

371

Cinematique a grande et moyenne echelles du milieu interstellaire ionise de la galaxie M33  

NASA Astrophysics Data System (ADS)

Des observations Fabry-Perot Halpha, en mode balayage, ont ete faites sur deux champs dans le kiloparsec central de la galaxie Messier 33. Ces donnees ont permis d'investiguer le comportement cinematique a grande et a moyenne echelles des complexes gazeux de cette galaxie, menant a plusieurs resultats interessants. Premierement, les effets de la propagation d'une onde de densite sur la morphologie et la cinematique des complexes gazeux affectes ont ete mis en evidence. Un examen morphologique des structures, et des gradients cinematiques perpendi-culaires au bras, a grande echelle, suggere la presence de l'onde de densite. De plus, la deprojection du champ de vitesses permet de devoiler une variation azimutale moyenne de 15 km s-1 pour la composante rotative dans la region du bras sud. Deuxiemement, une verification est faite sur la relation entre la dispersion de vitesses globale et le diametre geometrique des complexes gazeux de dimensions intermediaires, montrant que cette relation n'est pas exclusive aux regions H II geantes. La relation determinee ici est similaire a celle des petites regions H II galactiques ainsi qu'a celle d'un echantillon de region H II geantes extragalactiques. La pente de cette relation est de 1.5 +/- 0.6, en accord avec ces deux autres etudes. Ensuite, un echantillon de bulles Wolf-Rayet en expansion est etudie et une comparaison est faite entre celui-ci et certaines etudes precedentes portant sur des bulles galactiques ainsi que dans le Grand Nuage de Magellan. Ceci mene a une critique de la determination d'ages cinematiques et de la sequence evolutive proposee en fonction des types spectraux des etoiles responsables. Finalement, les regions H II classiques de M33 sont investiguees pour reveler deux nouvelles relations entre les parametres cinematiques des distributions de vitesses et de dispersions de vitesses. Ces relations sont: si=7.86+/-1.69+1.62+/- 0.43sc et sc=1.22+/-0.49+0.70+/- 0.12ssi , ou si est la moyenne de la distribution de largeurs de raies, ssi en est la dispersion et sc est la dispersion de la distribution des vitesses radiales, pour un complexe gazeux donne. Ces relations mettent a jour la nature bimodale des mouvements a meme ces objets, consistant de gradients a grande echelle et de turbulence. Deux nouvelles methodes sont proposees pour evaluer la moyenne de la composante turbulente et la valeur maximale de cette derniere. Un catalogue cinematique des grands complexes gazeux de notre etude, et des restes de supernova cinematiquement interessants sont donnes en appendice.

Godbout, Steve

372

Evaluation of the use of decision-support software in carcino-embryonic antigen (CEA)-based follow-up of patients with colorectal cancer  

PubMed Central

Background The present paper is a first evaluation of the use of "CEAwatch", a clinical support software system for surgeons for the follow-up of colorectal cancer (CRC) patients. This system gathers Carcino-Embryonic Antigen (CEA) values and automatically returns a recommendation based on the latest values. Methods Consecutive patients receiving follow-up care for CRC fulfilling our in- and exclusion criteria were identified to participate in this study. From August 2008, when the software was introduced, patients were asked to undergo the software-supported follow-up. Safety of the follow-up, experiences of working with the software, and technical issues were analyzed. Results 245 patients were identified. The software-supported group contained 184 patients; the control group contained 61 patients. The software was safe in finding the same amount of recurrent disease with fewer outpatient visits, and revealed few technical problems. Clinicians experienced a decrease in follow-up workload of up to 50% with high adherence to the follow-up scheme. Conclusion CEAwatch is an efficient software tool helping clinicians working with large numbers of follow-up patients. The number of outpatient visits can safely be reduced, thus significantly decreasing workload for clinicians.

2012-01-01

373

An Architectural Evolution Environment  

Microsoft Academic Search

We present Mae an architectural evolution environment, built upon a system model that combines architectural and configura- tion management concepts into a single representation. Through Mae, users can specify architectures (in terms of their constitu- ent components, connectors, and interfaces) in a traditional man- ner, manage the evolution of the architectures using a check-out\\/ check-in mechanism that tracks all changes,

Roshanak Roshandel

374

Framing Evolution Discussion Intellectually  

ERIC Educational Resources Information Center

|This study examines how a first-year biology teacher facilitates a series of whole-class discussions about evolution during the implementation of a problem-based unit. A communicative theoretical perspective is adopted wherein evolution discussions are viewed as social events that the teacher can frame intellectually (i.e., present or organize as…

Oliveira, Alandeom W.; Cook, Kristin; Buck, Gayle A.

2011-01-01

375

Evolution for Young Victorians  

ERIC Educational Resources Information Center

|Evolution was a difficult topic to tackle when writing books for the young in the wake of the controversies over Darwin's "Origin of Species." Authors who wrote about evolution for the young experimented with different ways of making the complex concepts of evolutionary theory accessible and less controversial. Many authors depicted presented…

Lightman, Bernard

2012-01-01

376

Representing Small Group Evolution  

Microsoft Academic Search

Understanding the dynamics of network evolution rests in part on the representation chosen to characterize the evolutionary process. We offer a simple, three-parameter representation based on subgraphs that capture three important properties of social networks: leadership, team alignment or bonding among members, and diversity of expertise. When plotted on this representation, the evolution of a typical small group such as

Whitman Richards; Nicholas C. Wormald

2009-01-01

377

Probabilistic developmental program evolution  

Microsoft Academic Search

A Probabilistic Model Building Genetic Programming technique for automatic program synthesis is introduced. The approach, called Probabilistic Developmental Program Evolution (PDPE), draws on the Probabilistic Incremental Program Evolution (PIPE) learning algorithm, but employs the Developmental Genetic Programming representations of Gene Expression Programming (GEP). PDPE induces a population of programs, encoded as fixed-length GEP chromosomes, by iteratively refining and randomly sampling

Elmira Ghoulbeigi; Marcus Vinicius dos Santos

2010-01-01

378

Treatment of Evolution Inconsistent  

ERIC Educational Resources Information Center

|State standards for academic content vary enormously in how well they cover the topic of evolution, with many of those documents either ignoring or giving scant treatment to the core principles of that established scientific theory. This article presents the analysis of Education Week on state's standards treatment of evolution. Nearly all the…

Cavanagh, Sean

2005-01-01

379

YARN: Animating Software Evolution  

Microsoft Academic Search

A problem that faces the study of software evolution is how to explore the aggregated and cumulative effects of changes that occur within a software system over time. In this paper we describe an approach to modeling, extracting, and animating the architectural evolution of a software sys- tem. We have built a prototype tool called YARN (Yet An- other Reverse-engineering

Abram Hindle; Zhen Ming Jiang; Walid Koleilat; Michael W. Godfrey; Richard C. Holt

2007-01-01

380

Entanglement of quantum evolutions  

Microsoft Academic Search

The notion of entanglement can be naturally extended from quantum states to the level of general quantum evolutions. This is achieved by considering multipartite unitary transformations as elements of a multipartite Hilbert space and then extended to general quantum operations. We show some connection between this entanglement and the entangling capabilities of the quantum evolution.

Paolo Zanardi; Viale Settimio Severo

2001-01-01

381

Evolution & Intelligent Design  

ERIC Educational Resources Information Center

|Advocates of Intelligent Design (ID) theory argue that evolution is a theory in crisis, ID is a legitimate scientific theory, and biology teachers should teach the controversy. Supporters of evolutionary theory testify that ID is a religious, not scientific, concept, and evolution is in no danger of bankruptcy, having survived 140 years of…

Staver, John R.

2003-01-01

382

Evolution: Theory or Dogma?  

ERIC Educational Resources Information Center

|In this paper the author examines the question of whether evolution is a theory or a dogma. He refutes the contention that there is a monolithic scientific conspiracy to present evolution as dogma and suggests that his own presentation might be more appropriately entitled "Creationism: Theory or Dogma." (PEB)|

Mayer, William V.

383

Framing Evolution Discussion Intellectually  

ERIC Educational Resources Information Center

This study examines how a first-year biology teacher facilitates a series of whole-class discussions about evolution during the implementation of a problem-based unit. A communicative theoretical perspective is adopted wherein evolution discussions are viewed as social events that the teacher can frame intellectually (i.e., present or organize as…

Oliveira, Alandeom W.; Cook, Kristin; Buck, Gayle A.

2011-01-01

384

Treatment of Evolution Inconsistent  

ERIC Educational Resources Information Center

State standards for academic content vary enormously in how well they cover the topic of evolution, with many of those documents either ignoring or giving scant treatment to the core principles of that established scientific theory. This article presents the analysis of Education Week on state's standards treatment of evolution. Nearly all the…

Cavanagh, Sean

2005-01-01

385

Voices for Evolution  

NSDL National Science Digital Library

This National Center for Science Education webpage includes statements from many religious organizations voicing tolerance for the theory of evolution as an explanation for the origin of life. Different faiths take different approaches to evolution versus creationism, but most affirm the responsibility of professional educators to make final decisions about the public school curriculum.

The National Center For Science Education, Inc.

386

The Nature of Evolution  

ERIC Educational Resources Information Center

The nature of evolution, the historical change in the universe, and the change that is caused by the workings of the dynamic processes at the smallest and largest scales are studied. It is viewed that the cumulative change in the historical systems is caused by evolution, which is a type of causal relationship and evolutionary processes could be…

Alles, David L.

2005-01-01

387

Learning and Evolution  

Microsoft Academic Search

In the last few years several researchers have resorted to artificial evolution (e.g., genetic algorithms) and learning techniques (e.g., neural networks) for studying the interaction between learning and evolution. These studies have been conducted for two different purposes: (a) looking at the performance advantages obtained by combining these two adaptive techniques; (b) understanding the role of the interaction between learning

Stefano Nolfi; Dario Floreano

1999-01-01

388

Mechanisms of molecular evolution.  

PubMed Central

Both drift and selection are important for nucleotide substitutions in evolution. The nearly neutral theory was developed to clarify the effects of these processes. In this article, the nearly neutral theory is presented with special reference to the nature of weak selection. The mean selection coefficient is negative, and the variance is dependent on the environmental diversity. Some facts relating to the theory are reviewed. As well as nucleotide substitutions, illegitimate recombination events such as duplications, deletions and gene conversions leave indelible marks on molecular evolution. Gene duplication and conversion are sources of the evolution of new gene functions. Positive selection is necessary for the evolution of novel functions. However, many examples of current gene families suggest that both drift and selection are at work on their evolution.

Ohta, T

2000-01-01

389

Mucins CA 125, CA 19.9, CA 15.3 and TAG72.3 as Tumor Markers in Patients with Lung Cancer: Comparison with CYFRA 21-1, CEA, SCC and NSE  

Microsoft Academic Search

Tumor marker serum levels were prospectively studied in 289 patients with suspected, but unconfirmed, lung cancer and in 513 patients with lung cancer [417 non-small cell lung cancer (NSCLC) patients and 96 small cell lung cancer (SCLC) patients]. In patients with benign disease, abnormal serum levels were found for the following tumor markers: CEA (in 6.6% of patients); CA 19.9

Rafael Molina; Jose Maria Auge; Jose Miguel Escudero; Ramon Marrades; Nuria Viñolas; Emilio Carcereny; Jose Ramirez; Xavier Filella

2008-01-01

390

Cri-du-chat syndrome with an increased level of proline and threonine  

Microsoft Academic Search

The typical symptoms of the cri-du-chat syndrome (46,XX,5p-) are described in an infant. The frequency of kidney anomalies and increased serum and urine levels of proline and threonine, described for the first time in a single case of cri-du-chat syndrome, are discussed.

U. Kühner; M. Büsse; G. Buchinger

1974-01-01

391

VESTIGES HUMAINS DES NIVEAUX DE L'AURIGNACIEN ANCIEN DU SITE DE BRASSEMPOUY (LANDES)  

Microsoft Academic Search

The Brassempouy locality is situated in the Chalosse region in the southern part of the French department of Landes, two kilometers from the village of Brassempouy and forty kilometers south of Mont-de-Marsan. It includes several caves (grotte du Pape, grotte des Hyènes, galerie Dubalen, galerie du Mégacéros) which are part of a complex karstic system

Dominique HENRY-GAMBIER; Bruno MAUREILLE; Randall WHITE

392

Une évaluation de la qualité du cannabis à usage thérapeutique aux Pays-Bas  

Microsoft Academic Search

Depuis 2003, du cannabis à usage thérapeutique est délivré sur ordonnance dans les pharmacies aux Pays-Bas. La culture, la transformation et le conditionnement de la matière végétale sont réal- isés selon les normes pharmaceutiques et sont supervisés par le Bureau du Cannabis Médical (OMC). La qualité est garantie par des tests réguliers effectués par des laboratoires certifiés. Ce- pendant, un

Arno Hazekamp

2006-01-01

393

Of Faith and Fiction: Teaching W. E. B. Du Bois and Religion  

ERIC Educational Resources Information Center

W. E. B. Du Bois (1868-1963) is widely known as a champion for the political rights of African Americans, founder of the National Association for the Advancement of Colored People (NAACP), aggressive advocate of Pan-Africanism, staunch supporter of female suffrage, and one of the creative forces behind the Harlem Renaissance. Further still, Du

Sinitiere, Phillip Luke

2012-01-01

394

Updated isopach maps of Prairie du Chien, Trempealeau, and Munising of Michigan basin  

Microsoft Academic Search

As part of an ongoing project concerning the Lower Ordovician and Cambrian sections of the Michigan basin, consistent correlations from modern electrical logs have been used to develop structural and isopach maps of the Prairie du Chien, Trempealeau, and Munising of the Michigan basin. The Prairie du Chien is subdivided into the upper Bruggers sandstone, the middle Foster formation, and

R. V. Brady; R. J. Dehaas

1987-01-01

395

Of Faith and Fiction: Teaching W. E. B. Du Bois and Religion  

ERIC Educational Resources Information Center

|W. E. B. Du Bois (1868-1963) is widely known as a champion for the political rights of African Americans, founder of the National Association for the Advancement of Colored People (NAACP), aggressive advocate of Pan-Africanism, staunch supporter of female suffrage, and one of the creative forces behind the Harlem Renaissance. Further still, Du

Sinitiere, Phillip Luke

2012-01-01

396

Lambeaux autofermants pour le traitement des brulures electriques du scalp par haut voltage  

PubMed Central

Summary Les brûlures électriques par haut voltage sont responsables de gros dégâts tissulaires en immédiat et dans les jours suivant l’accident du fait de la chaleur importante dégagée par effet joule et de la thrombose microvasculaire évolutive. Les pertes de substances du scalp secondaires à ces brûlures nécessitent une couverture par lambeaux vu la destruction du périoste et du calvarium en regard. De juin 1997 à juin 2008, 15 patients ont été traités pour des pertes de substance du scalp secondaires à des brûlures électriques par haut voltage de diamètre allant de 8 à 11 cm et siégeant dans la région tonsurale. Ces patients ont été opérés dans la première semaine suivant l’accident. Les pertes de substance du scalp de taille moyenne secondaires à ces brûlures peuvent être couvertes per primam de façon fiable par des lambeaux locaux axialisés et multiples. Nous relatons l’expérience du Service de Chirurgie Plastique du Centre Hospitalier Universitaire Ibn-Sina, Rabat, Maroc, dans la gestion et la prise en charge de ces brûlures.

Hafidi, J.; El Mazouz, S.; El Mejatti, H.; Fejjal, N.; Gharib, N.E.; Abbassi, A.; Belmahi, A.M.

2011-01-01

397

76 FR 78968 - Environmental Impact Statement: Cook and DuPage Counties, IL  

Federal Register 2010, 2011, 2012, 2013

...Federal Aviation Administration Environmental Impact Statement: Cook and DuPage Counties, IL AGENCIES: Federal Highway Administration...Statement will be prepared for the Elgin O'Hare--West Bypass in Cook and DuPage Counties, Illinois. FOR FURTHER INFORMATION...

2011-12-20

398

Bilan de l'emploi en 1973, année médiane du VIe Plan  

Microsoft Academic Search

[fre] Bilan de l'emploi en 1973, année médiane du VIe Plan par Bruno DURIEUX . Année de forte activité économique, 1973 restera caractérisée par un haut niveau de croissance de la production intérieure brute, une forte progression des emplois et une stabilisation du chômage. Le bilan de l'année laisse cependant apparaître deux importants sujets de préoccupation : les tensions sur

Bruno Durieux

1974-01-01

399

Paléomagnétisme et évolution du bloc Scythe-Touran du Permien inférieur au Trias supérieur  

NASA Astrophysics Data System (ADS)

The palaeomagnetic studies carried out on Permian to Triassic formations from the north-west part of the Great Caucasus and from southwest Turkmenistan question the existing palaeogeographic models of evolution of this Central Asia region. The impressive differences in latitude between the Scythian and Turan plates, and the East European Platform during the Permo-Triassic, lead us to suppose that the Scythian-Turan blocks moved away from Eurasia during the Permian in a large transversal westward movement. The docking of this block onto the southern border of Eurasia probably occurred at the end of the Triassic.

Lemaire, Marie-Marie; Westphal, Michel; Montigny, Raymond; Gurevitch, Evgueni L.; Feinberg, Hugues; Pozzi, Jean-Pierre; Nazarov, Khodjamourad

1998-10-01

400

The Creation/Evolution Continuum.  

ERIC Educational Resources Information Center

|Many believe that creation and evolution are two totally different theories. Encourages rejection of the creation/evolution dichotomy and recognition of the creation/evolution continuum. (Contains 19 references.) (ASK)|

Scott, Eugenie C.

2001-01-01

401

The Creation/Evolution Continuum.  

ERIC Educational Resources Information Center

Many believe that creation and evolution are two totally different theories. Encourages rejection of the creation/evolution dichotomy and recognition of the creation/evolution continuum. (Contains 19 references.) (ASK)

Scott, Eugenie C.

2001-01-01

402

Influence des interactions du couple ciment/adjuvant dispersant sur les proprietes des betons: Importance du mode d'introduction des adjuvants  

NASA Astrophysics Data System (ADS)

Les travaux de recherche de cette these de doctorat ont porte sur les phenomenes d'incompatibilite (ou de compatibilite) ciment/adjuvant dispersant en mettant l'accent sur l'influence du mode d'introduction des adjuvants sur les proprietes des betons frais et durcis. Les aspects physiques et chimiques de l'interaction ciment/adjuvant a ete relies aux proprietes des betons en tenant compte du rapport E/C, de la teneur en C3A du ciment ainsi que du type d'adjuvant dispersant. Le programme experimental propose debute par une etude rheologique et mecanique sur pate et sur beton. Le comportement du superplastifiant a base de polynaphtalene (PNS) depend surtout de son interaction avec les premiers produits d'hydratation du ciment. Cette interaction du superplastifiant PNS avec le ciment est remarquablement differente dans le cas ou l'ajout du PNS est differe de quelques minutes. Lorsque le superplastifiant PNS est introduit directement avec l'eau de gachage, on remarque la formation d'un gel blanc compose d'ettringite, de CaCO 3 et de polynaphtalene et ce compose organo-mineral est presque inexistant lorsque le superplastifiant PNS est ajoute en mode differe. Ce gel organo-mineral se forme a partir de la solution entre les aluminates de calcium hydrates, les sulfates et le PNS, et est responsable de la perte d'affaissement du beton. Les analyses au microscope electronique a balayage montrent que l'introduction du superplastifiant PNS en mode S1 (ajout direct) engendre la precipitation d'une plus grande quantite d'ettringite et de produit organo-mineral. Cette ettringite finement cristallisee, abondante et enchevetree aura pour consequence de diminuer les proprietes rheologiques des betons et des pates. Ce phenomene ne s'observe pas lorsque le superplastifiant PNS est introduit en mode differe. Le mode d'introduction du superplastifiant a base de polyacrylate (PAE) n'affecte nullement le comportement rheologique du beton. Par ailleurs, le gel organo-mineral n'apparait pas avec le superplastifiant PAE. Le superplastifiant PNS et son adsorption n'est pas fonction de la teneur en C3A. Un resultat tres important est la concentration en calcium qui est beaucoup plus elevee avec le superplastifiant PNS, surtout avec le ciment a forte teneur en C3A. Il semble que l'hydratation des phases du ciment soit controlee par la presence du superplastifiant PAE. Les analyses au microscope electronique a balayage avec le superplastifiant a base de polyacrylate apres 60 minutes d'hydratation du ciment montre de facon tres nette que la surface des grains de ciment est denudee de tout produit d'hydratation. En ce qui concerne les reducteurs d'eau, l'ajout en mode differe produit un certain effet benefique sur la rheologie et depend aussi du dosage surtout avec le reducteur d'eau de portee moyenne a base de lignosulfonate modifie (LM). Dans tous les cas, le reducteur d'eau ordinaire CG retarde plus la prise que le reducteur d'eau de portee moyenne LM. (Abstract shortened by UMI.)

Baalbaki, Moussa

403

Physicochemical characterisation of depleted uranium (DU) particles at a UK firing test range.  

PubMed

Depleted uranium (DU) particles were isolated from soils at Eskmeals, UK, where DU munitions have been tested against hard targets and unfired DU buried in soils for corrosion studies. Using electron microscopy and X-ray analyses, three classes of particles were identified: (1) DU aerosols and fragments, typically 1-20 ?m diameter, composed mainly of uranium as UO(2) and U(3)O(8), (2) solidified molten particles, typically 200-500 ?m diameter, composed of U, mixed with Fe from target materials and (3) deposits and coatings, often of metaschoepite on sand grains up to 500 ?m diameter. The first two particle types are derived from firing impacts, the last from corrosion of buried uranium metal. Alpha and mass spectrometry allowed quantitative elemental and isotopic characterisation of DU-containing particulate environmental samples. PMID:20855109

Sajih, Mustafa; Livens, Francis R; Alvarez, Rebeca; Morgan, Mathew

2010-09-19

404

Questions Sur la Diffusion de l'Esprit du Lieu : Le Cas des Routes Culturelles en Europe du Sud-Est  

Microsoft Academic Search

L'Europe du Sud-est est un lieu particulier, carrefour de civilisations différentes et mosaïque de cultures et de populations. Les caractéristiques physicogéographiques et les conjonctures historiques en Europe du Sud-est ont formé un milieu de discontinuités et de diversités importantes. Ce fait constitue le fond pertinent sur lequel une opulence patrimoniale matérielle et immatérielle appréciable s'épanouit. La richesse au niveau ethnologique,

Tsilimigkas Giorgos

405

Vers une proposition d'integration de l'approche objective et subjective de la situation d'achat dans l'etude du comportement du consommateur  

Microsoft Academic Search

Si l'influence de la situation d'achat sur le comportement du consommateur est admise, les problèmes quant au choix d'une mesure objective ou subjective de cette variable se posent toujours. Dans le but de montrer que l'approche objective et subjective du contexte d'achat fournissent des informations complémentaires sur les agissements de l'individu, nous avons mené une étude empirique auprès de 200

Jean-François LEMOINE

2000-01-01

406

Elaboration d'une carte d'occupation du sol du bassin versa lilt de la Leysse a partir d'images HRV de SPOT  

Microsoft Academic Search

Dans le cadre de travaux, menés au sein Laboratoire de Chimie et lngénierie de l'Environnemcnt de l'Universite de Savoie, sur Ie suivi de la qualite des eaux superficielles du bassin versant de la Leysse, une carte d'occupations du sol est rélisée á partir d'images satellites de HRV de SPOT. Deux images ont été utilisées, une multibande (XS) et une panchromatique

P. Landru; A. Oumedjbeur; et E. CLEMENT

1995-01-01

407

[Utility of sampling perfection with application optimized contrasts using different flip angle evolutions method in magnetic resonance imaging of carotid artery plaque].  

PubMed

In the carotid artery plaque diagnosis, it is said that properties evaluation is important. For this inspection, it is general to use electrocardiogram (ECG)-trigger-dark blood (DB)-fat suppression (fs)-turbo spin echo (TSE)-T1 weighted image (T1WI), T2WI, and magnetization prepared rapid gradient echo (MPRAGE) methods though many problems still remain. This time, a comparative study of the carotid artery plaque diagnosis that used the sampling perfection with application optimized contrasts was made. This used different flip angle evolutions method sampling perfection with application optimized contrasts using different flip angle evolutions (SPACE) method that was 3 dimension (3D) imaging procedure that used variable flip angle with the law so far. The subjects were normal volunteers, handmade phantoms changed by T1 and T2 value, and the five patients on five cases who had taken carotid endoarterectomy (CEA) (male, mean 70.6 yr). Findings by the pathologist were obtained for the CEA enforcement patient. There is an excellent result in the contrast ratio by phantom, the signal intensity ratio of a clinical patient, and the comparison with pathological findings. The SPACE method can solve various problems, be evaluated by a properties evaluation of the plaque, a grasp of the range, and an arbitrary section, and be devised as a useful imaging procedure. PMID:22821161

Urata, Tetsuya; Yamamoto, Hidetaka; Ikuta, Naoaki; Uchikoshi, Masato

2012-01-01

408

Cultural Evolution and SETI  

NASA Astrophysics Data System (ADS)

The Drake Equation for the number of radio communicative technological civilizations in the Galaxy encompasses three components of cosmic evolution: astronomical, biological and cultural. Of these three, cultural evolution totally dominates in terms of the rapidity of its effects. Yet, SETI scientists do not take cultural evolution into account, perhaps for understandable reasons, since cultural evolution is not well-understood even on Earth and is unpredictable in its outcome. But the one certainty for technical civilizations billions, millions, or even thousands of years older than ours is that they will have undergone cultural evolution. Cultural evolution potentially takes place in many directions, but this paper argues that its central driving force is the maintenance, improvement and perpetuation of knowledge and intelligence, and that to the extent intelligence can be improved, it will be improved. Applying this principle to life in the universe, extraterrestrials will have sought the best way to improve their intelligence. One possibility is that they may have long ago advanced beyond flesh-and-blood to artificial intelligence, constituting a postbiological universe. Although this subject has been broached, it has not been given the attention it is due from its foundation in cultural evolution. Nor has the idea of a postbiological universe been carried to its logical conclusion, including a careful analysis of the implications for SETI. SETI scientists, social scientists, and experts in AI should consider the strengths and weaknesses of this new paradigm.

Dick, S. J.

2009-12-01

409

Properties, use and health effects of depleted uranium (DU): a general overview.  

PubMed

Depleted uranium (DU), a waste product of uranium enrichment, has several civilian and military applications. It was used as armor-piercing ammunition in international military conflicts and was claimed to contribute to health problems, known as the Gulf War Syndrome and recently as the Balkan Syndrome. This led to renewed efforts to assess the environmental consequences and the health impact of the use of DU. The radiological and chemical properties of DU can be compared to those of natural uranium, which is ubiquitously present in soil at a typical concentration of 3 mg/kg. Natural uranium has the same chemotoxicity, but its radiotoxicity is 60% higher. Due to the low specific radioactivity and the dominance of alpha-radiation no acute risk is attributed to external exposure to DU. The major risk is DU dust, generated when DU ammunition hits hard targets. Depending on aerosol speciation, inhalation may lead to a protracted exposure of the lung and other organs. After deposition on the ground, resuspension can take place if the DU containing particle size is sufficiently small. However, transfer to drinking water or locally produced food has little potential to lead to significant exposures to DU. Since poor solubility of uranium compounds and lack of information on speciation precludes the use of radioecological models for exposure assessment, biomonitoring has to be used for assessing exposed persons. Urine, feces, hair and nails record recent exposures to DU. With the exception of crews of military vehicles having been hit by DU penetrators, no body burdens above the range of values for natural uranium have been found. Therefore, observable health effects are not expected and residual cancer risk estimates have to be based on theoretical considerations. They appear to be very minor for all post-conflict situations, i.e. a fraction of those expected from natural radiation. PMID:12500797

Bleise, A; Danesi, P R; Burkart, W

2003-01-01

410

Quelques propriétés de l’intégrale stochastique du type noncausal  

Microsoft Academic Search

\\u000a Abstract  We show that the stochastic integral of noncausal type is a natural generalisation of the symmetric integral of Stratonovich-Fisk.\\u000a We also show other relevant results and present their applications to the theory of stochastic integral equations.\\u000a \\u000a On démontre que l’intégrale stochastique du type noncausal est une généralisation naturelle de l’intégrale symétrique de Stratonovich-Fisk\\u000a et on montre quelques applications des résultats

Shigeyoshi Ogawa

1984-01-01

411

MéThodes Hilbertiennes en ThéOrie du Potentiel  

Microsoft Academic Search

\\u000a L'emploi des méthodes hilbertiennes en théorie du potentiel remonteau théorème classique sur le signe de l'énergie, et on\\u000a peut même y rattacher la méthode de variation de Gauss. Ce point de vue a été systématiquement développé, pendant la période\\u000a 1935–1950 par De La Valiée Poussin, M. Riesz, Frostman et surtout H. Cartan [6]\\u000a \\u000a \\u000a Cependant ces divers auteurs ne font pas

J. Deny

412

Educational Priorities for Children with Cri-Du-Chat Syndrome  

Microsoft Academic Search

There are few data on the educational needs of children with cri-du-chat syndrome: a neurodevelopmental disorder that affects\\u000a learning and development. We therefore designed an Internet survey to identify parents’ educational priorities in relation\\u000a to children’s level of need\\/ability. The survey listed 54 skills\\/behaviors (e.g., toileting, expresses wants and needs, and\\u000a tantrums) representing 10 adaptive behavior domains (e.g., self-care, communication,

Keenan A. Pituch; Vanessa A. Green; Robert Didden; Lisa Whittle; Mark F. O’Reilly; Giulio E. Lancioni; Jeff Sigafoos

2010-01-01

413

Wheat Evolution: Sedimentation Testing  

NSDL National Science Digital Library

In this activity (p.8-9 of PDF), learners investigate the evolution of wheat by conducting sedimentation tests on different flours. The evolution of wheat from wild grasses demonstrates the dramatic effect of both natural and directed evolution on the structure of a crop plant and the chemical makeup of the product harvested from it. These activities illustrate the changes to both the structure and the chemistry of the wheat plant. Note: Sedimentation test can also be done using SDS detergent and lactic acid instead of soap and vinegar.

Council, Biotechnology A.

2012-01-01

414

Wheat Evolution: Dough Rising  

NSDL National Science Digital Library

In this activity (p.6-7 of PDF), learners investigate the evolution of wheat by creating dough from different flours, observing the samples of dough as they rise, and then baking the dough. The evolution of wheat from wild grasses demonstrates the dramatic effect of both natural and directed evolution on the structure of a crop plant and the chemical makeup of the product harvested from it. These activities illustrate the changes to both the structure and the chemistry of the wheat plant.

Council, Biotechnology A.

2012-01-01

415

Evolution of thymus organogenesis.  

PubMed

The thymus is the primary organ for functional T lymphocyte development in jawed vertebrates. A new study in the jawless fish, lampreys, indicates the existence of a primitive thymus in these surviving representatives of the most ancient vertebrates, providing strong evidence of co-evolution of T cells and thymus. This review summarizes the wealth of data that have been generated towards understanding the evolution of the thymus in the vertebrates. Progress in identifying genetic networks and cellular mechanisms that control thymus organogenesis in mammals and their evolution in lower species may inspire the development of new strategies for medical interventions targeting faulty thymus functions. PMID:22266420

Ge, Qing; Zhao, Yong

2012-01-13

416

Evolution and Disorder  

PubMed Central

The evolution of disordered proteins or regions of proteins differs from ordered proteins because of the differences in their sequence composition, intramolecular contacts and function. Recent assessments of disordered protein evolution at the sequence, structural and functional levels support this hypothesis. Disordered proteins have a different pattern of accepted point mutations, exhibit higher rates of insertions and deletions, and generally, but not always, evolve more rapidly than ordered proteins. Even with these high rates of sequence evolution, a few examples have shown that disordered proteins maintain their flexibility under physiological conditions, and it is hypothesized that they maintain specific structural ensembles.

Brown, Celeste J.; Johnson, Audra K.; Dunker, A. Keith; Daughdrill, Gary W.

2011-01-01

417

Arguing for Evolution  

NSDL National Science Digital Library

Opponents to teaching the theory of evolution declare that it is only a theory and not a fact; and that science relies on observation, replication, and experimentation, but nobody has seen the origin of the universe or the evolution of species, nor have these events been replicated in the laboratory or by experiment. In everyday speech, a theory is considered to be an imperfect fact. In science, however, a theory is based on a body of knowledge. This free selection from Evolution in Perspective addresses these controversial issues and includes the Table of Contents, and a Foreward section.

Ayala, Francisco J.

2004-01-01

418

Random quantum evolution  

NASA Astrophysics Data System (ADS)

The quantum no-cloning theorem and no-deleting theorem may be the most important quantum features for quantum communications or quantum computations. In this paper, we concentrate typical properties of random quantum evolution. We obtain that universal random evolutions change the generic unknown pure states into their orthogonal states approximately. Moreover, typical random evolutions distort the von Neumann entropy with constants. These results are extended to mixed states with a stronger orthogonal preparation ability. These typical characters are very important for quantum information retrieving or various quantum tasks.

Luo, Ming-Xing; Deng, Yun; Ma, Song-Ya; Chen, Xiu-Bo; Qu, Zhi-Guo

2013-06-01

419

Number and cost of claims linked to minor cervical trauma in Europe: results from the comparative study by CEA, AREDOC and CEREDOC  

PubMed Central

Comparative epidemiological study of minor cervical spine trauma (frequently referred to as whiplash injury) based on data from the Comité Européen des Assurances (CEA) gathered in ten European countries. To determine the incidence and expenditure (e.g., for assessment, treatment or claims) for minor cervical spine injury in the participating countries. Controversy still surrounds the basis on which symptoms following minor cervical spine trauma may develop. In particular, there is considerable disagreement with regard to a possible contribution of psychosocial factors in determining outcome. The role of compensation is also a source of constant debate. The method followed here is the comparison of the data from different areas of interest (e.g., incidence of minor cervical spine trauma, percentage of minor cervical spine trauma in relationship to the incidence of bodily trauma, costs for assessment or claims) from ten European countries. Considerable differences exist regarding the incidence of minor cervical spine trauma and related costs in participating countries. France and Finland have the lowest and Great Britain the highest incidence of minor cervical spine trauma. The number of claims following minor cervical spine trauma in Switzerland is around the European average; however, Switzerland has the highest expenditure per claim at an average cost of €35,000.00 compared to the European average of €9,000.00. Furthermore, the mandatory accident insurance statistics in Switzerland show very large differences between German-speaking and French- or Italian-speaking parts of the country. In the latter the costs for minor cervical spine trauma expanded more than doubled in the period from 1990 to 2002, whereas in the German-speaking part they rose by a factor of five. All the countries participating in the study have a high standard of medical care. The differences in claims frequency and costs must therefore reflect a social phenomenon based on the different cultural attitudes and medical approach to the problem including diagnosis. In Switzerland, therefore, new ways must be found to try to resolve the problem. The claims treatment model known as “Case Management” represents a new approach in which accelerated social and professional reintegration of the injured party is attempted. The CEA study emphasizes the fundamental role of medicine in that it postulates a clear division between the role of the attending physician and the medical expert. It also draws attention to the need to train medical professionals in the insurance business to the extent that they can interact adequately with insurance professionals. The results of this study indicate that the usefulness of the criterion of so-called typical clinical symptoms, which is at present applied by the courts to determine natural causality and has long been under debate, is inappropriate and should be replaced by objective assessment (e.g. accident and biomechanical analysis). In addition, the legal concept of adequate causality should be interpreted in the same way in both third party liability and social security law, which is currently not the case.

Chappuis, Guy

2008-01-01

420

Workshop on Molecular Evolution.  

National Technical Information Service (NTIS)

Molecular evolution has become the nexus of many areas of biological research. It both brings together and enriches such areas as biochemistry, molecular biology, microbiology, population genetics, systematics, developmental biology, genomics, bioinformat...

M. P. Cummings

2004-01-01

421

Evolution: Fact and Theory  

NSDL National Science Digital Library

The issue-focused, peer-reviewed article demonstrates that evolution is both fact and theory, explaining the major patterns of change in nature, how these changes occur, and the fossil and genetic evidence of change.

Richard Lenski (Michigan State University;)

2000-09-01

422

Classification and Evolution  

NSDL National Science Digital Library

This laboratory activity has students first classify 14 living species into genera, families, etc. Then they construct an evolutionary tree of the Caminalcules using an additional 57 fossil species. This illustrates how modern classification schemes attempt to reflect evolutionary history. In the process of doing this exercise, the students are also introduced to concepts such as convergent evolution and vestigial structures. The purpose of this lab is to illustrate the principles of classification and some of the processes of evolution. These exercises are done with artificial organisms so that students will approach the task with no preconceived notion as to how they should be classified. This means that they will have to deal with problems such as convergent evolution just as a taxonomist would. This document contains a cover sheet, the Classification and Evolution Lab handout, pictures of the Caminalcules, instructor notes for both a two- and three-hour lab, and a diagram of the correct phylogenetic tree.

Gendron, Robert

423

Evolution of bacterial genomes.  

PubMed

This review examines evolution of bacterial genomes with an emphasis on RNA based life, the transition to functional DNA and small evolving genomes (possible plasmids) that led to larger, functional bacterial genomes. PMID:9111921

Trevors, J T

1997-03-01

424

Co-Evolution.  

ERIC Educational Resources Information Center

|Discusses the role of techniques of DNA analysis in assessing the genetic relationships between various species. Focuses on wolf-dog evolution using DNA evidence and historical data about human/wolf-dog relationships. (DDR)|

McGhee, Robert

2002-01-01

425

Climate and Human Evolution  

NSDL National Science Digital Library

In this video segment adapted from NOVA: Becoming Human, learn how the analysis of rock layers and ocean sediments supports the theory that rapid climate change may have jump-started human evolution two million years ago.

Foundation, Wgbh E.

2010-11-30

426

Evolution: Always New  

ERIC Educational Resources Information Center

|The changes in the evolution due to changes in science are explored. These changes are frustrating to paleontologists, especially when they are trying to date a singular event, like a cataclysm that precipitated a mass extinction.|

Flannery, Maura C.

2005-01-01

427

Cell cycle: Complex evolution  

Microsoft Academic Search

Cell division is fundamental to life, and so might be expected to have changed little during evolution. Data from four species show that the genes involved can vary, but the regulation of complexes is a common theme.

Gavin Sherlock

2006-01-01

428

Menstrual cycle dependent variability for serum tumor markers CEA, AFP, CA 19-9, CA 125 and CA 15-3 in healthy women.  

PubMed

Information on menstrual cycle dependent variation of tumor markers in healthy women is a subject of diagnostic efficiency and has an impact in elucidating the normal function of these markers. In this study midfollicular and midluteal concentrations of serum CEA, AFP, CA 19-9, CA 125, CA 15-3 and their relations with LH, FSH, prolactin, estradiol and progesterone were evaluated during ovulatory cycles in a group of 23 healthy female individuals. Samples were collected on the 7th and 21st day of the same menstrual cycle. Tumor marker and hormone concentrations were determined with chemiluminescence or electrochemiluminescence EIA methods. A significant phase-dependent difference was observed for CA 15-3, midluteal concentrations (mean +/- SEM; 26.33 +/- 1.56 U/ml) higher than the midfollicular (mean +/- SEM; 19.27 +/- 1.49 U/ml) concentrations (p < 0.001). But an obvious difference for other tumor markers investigated did not exist. Significant correlations of follicular and luteal CA 125 levels with body mass index of the subjects were observed (r:0.52, p < 0.05 and r:0.57, p < 0.005, respectively). CA 15-3 antigen is a product of the MUC-1 gene which is expressed in abundance by endometrial epithelial cells in the secretory phase of the menstrual cycle which may be the potential source of variability. The association of CA 125 levels with obesity suggests a possible role of adipose tissue in CA 125 metabolism. In conclusion our data suggest that in healthy women serum CA 15-3 levels are significantly elevated in the midluteal phase of the menstrual cycle compared to midfollicular phase. Therefore, consideration of menstrual cycle dependent variability for CA 15-3 appears indicated in interpretation of individual results. PMID:10689549

Erba?ci, A B; Yilmaz, N; Kutlar, I

1999-12-01

429

A Pilot Study of MUC-1/CEA/TRICOM Poxviral-Based Vaccine in Patients with Metastatic Breast and Ovarian Cancer  

PubMed Central

Purpose PANVAC is a recombinant poxviral vaccine that contains transgenes for MUC-1, CEA and 3 T-cell costimulatory molecules. This study was conducted to obtain preliminary evidence of clinical response in metastatic breast and ovarian cancer patients. Experimental design Twenty-six patients were enrolled and given monthly vaccinations. Clinical and immune outcomes were evaluated. Results These patients were heavily pretreated, with 21 of 26 patients having ? 3 prior chemotherapy regimens. Side effects were largely limited to mild injection-site reactions. Breast cancer: For the 12 patients enrolled, median time to progression was 2.5 months (1 – 37+) and median overall survival was 13.7 months. Four patients had stable disease. One patient had a complete response by RECIST and remains on study ? 37 months, with a significant drop in serum IL-6 and IL-8 by day 71. Another patient with metastatic disease confined to the mediastinum had a 17% reduction in mediastinal mass and was on study for 10 months. Patients with stable or responding disease had fewer prior therapies and lower tumor marker levels than patients with no evidence of response. Ovarian cancer:Median time to progression for patients (n=14) was 2 months (1 – 6) and median overall survival was 15.0 months. Updated data are presented here for one patient treated with this vaccine in a previous trial, with a time to progression of 38 months. Conclusions Some patients who had limited tumor burden with minimal prior chemotherapy appeared to benefit from the vaccine. Further studies to confirm these results are warranted.

Mohebtash, Mahsa; Tsang, Kwong-Yok; Madan, Ravi A.; Huen, Ngar-Yee; Poole, Diane J.; Jochems, Caroline; Jones, Jacquin; Ferrara, Theresa; Heery, Christopher R.; Arlen, Philip M.; Steinberg, Seth M.; Pazdur, Mary; Rauckhorst, Myrna; Jones, Elizabeth C.; Dahut, William L.; Schlom, Jeffrey; Gulley, James L.

2011-01-01

430

Evolution and Religion  

Microsoft Academic Search

\\u000a How are Creationist students, along with the unique philosophical conundrums they bring to science education, distinctive\\u000a amidst their peers? In this chapter, I articulate a framework to think about religious ontology vis-à-vis evolution. As I\\u000a argue, there are essentially three meaningful ontological positions toward evolution one might encounter when speaking with\\u000a Americans. This perspective moves past a continuum model of

David E. Long

431

Physical Principles of Evolution  

NASA Astrophysics Data System (ADS)

Theoretical biology is incomplete without a comprehensive theory of evolution, since evolution is at the core of biological thought. Evolution is visualized as a migration process in genotype or sequence space that is either an adaptive walk driven by some fitness gradient or a random walk in the absence of (sufficiently large) fitness differences. The Darwinian concept of natural selection consisting in the interplay of variation and selection is based on a dichotomy: All variations occur on genotypes whereas selection operates on phenotypes, and relations between genotypes and phenotypes, as encapsulated in a mapping from genotype space into phenotype space, are central to an understanding of evolution. Fitness is conceived as a function of the phenotype, represented by a second mapping from phenotype space into nonnegative real numbers. In the biology of organisms, genotype-phenotype maps are enormously complex and relevant information on them is exceedingly scarce. The situation is better in the case of viruses but so far only one example of a genotype-phenotype map, the mapping of RNA sequences into RNA secondary structures, has been investigated in sufficient detail. It provides direct information on RNA selection in vitro and test-tube evolution, and it is a basis for testing in silico evolution on a realistic fitness landscape. Most of the modeling efforts in theoretical and mathematical biology today are done by means of differential equations but stochastic effects are of undeniably great importance for evolution. Population sizes are much smaller than the numbers of genotypes constituting sequence space. Every mutant, after all, has to begin with a single copy. Evolution can be modeled by a chemical master equation, which (in principle) can be approximated by a stochastic differential equation. In addition, simulation tools are available that compute trajectories for master equations. The accessible population sizes in the range of 10^7le Nle 10^8 molecules are commonly too small for problems in chemistry but sufficient for biology.

Schuster, Peter

432

Stochastic Multivariate Evolution  

Microsoft Academic Search

\\u000a The discussions of stochastic methods in previous chapters were related to the consideration of a single random variable.\\u000a This approach is appropriate to explain the basic structure of evolution equations for stochastic processes and their PDFs.\\u000a On the other hand, most applications cannot be handled on the basis of methods that describe the evolution of single variables.\\u000a Real processes usually

Stefan Heinz

433

Evolution in Revolution  

PubMed Central

Biological evolution represents one of the most successful, but also controversial scientific concepts. Ever since Charles Darwin formulated his version of evolution via natural selection, biological sciences experienced explosive development and progress. First of all, although Darwin could not explain how traits of organisms, selected via natural selection, are inherited and passed down along generations; his theory stimulated research in this respect and resulted in the establishment of genetics and still later in the discovery of DNA and genome sequencing some hundred years after his evolutionary theory. Nevertheless, there are several weaknesses in classical Darwinian as well as Neodarwinian gene-centric views of biological evolution. The most serious drawback is its narrow focus: the modern evolutionary synthesis, as formulated in the 20th Century, is based on the concept of gene and on the mathematical/statistical analysis of populations. While Neodarwinism is still generally considered a valid theory of biological evolution, its narrow focus and incompatibility with several new findings and discoveries calls for its update and/or transformation. Either it will be replaced with an updated version or, if not flexible enough, it will be replaced by a new theory. In his book “Evolution — A New View from the 21st Century,”1 James A. Shapiro discusses these problems as well as newly emerging results which are changing our understanding of biological evolution. This new book joins a row of several other recent books highlighting the same issues.2–13

2011-01-01

434

Building an evolution transformation library  

Microsoft Academic Search

We have been developing knowledge-based tools to support the evolutionary development of specifications. Evolution is accomplished by means of evolution transformations, which are meaning-changing transformations applied to formal specifications. A sizable library of evolution transformations has been developed for our specification language, Gist. This paper assesses the results of our previous work on evolution transformations. It then describes our current

W. Lewis Johnson; Martin S. Feather

1990-01-01

435

Selection and the Evolution of Industry  

Microsoft Academic Search

Recent evidence shows that within an industry, smaller firms grow\\u000d\\u000a\\u0009faster and are more likely to fail than large firms. This paper provides\\u000d\\u000a\\u0009a theory of selection with incomplete information that is consistent\\u000d\\u000a\\u0009with these and other findings. Firms learn about their efficiency\\u000d\\u000a\\u0009as they operate in the industry. The efficient grow and survive;\\u000d\\u000a\\u0009the inefficient decline and fail. A

Boyan Jovanovic

1982-01-01

436

Chimiothérapie néoadjuvante et cancers du sein avancés ou inflammatoires à Yaoundé (Cameroun)  

Microsoft Academic Search

Résumé  Le but de cette étude était de relever les facteurs limitant la pratique de la chimiothérapie néoadjuvante dans le traitement\\u000a des cancers du sein avancés ou inflammatoires en milieu africain au sud du Sahara. Il s’agit d’une étude prospective transversale\\u000a dans laquelle l’équipe médicale s’était proposée d’administrer une chimiothérapie avant le traitement de tous les cancers\\u000a du sein avancés ou

S. Takongmo; J. Yomi; M. L. Guifo; C. Pisoh Tangnyin; P. Ndom; J. M. Mendimi Nkodo; J. L. Essame-Oyono

437

Evolution of Metabolism  

NASA Astrophysics Data System (ADS)

This chapter is devoted to the discussion of the evolution of metabolism, with a particular focus towards redox metabolism and the utilization of redox energy by life. We will deal with various aspects of metabolism that involve direct interaction with, and the extraction of energy from, the environment (catabolic metabolism) and will talk briefly of the reactions that affect mineral formation and dissolution. However, we will de-emphasize the aspects related to the formation of complex molecules and organisms. To some, it will be refreshingly brief; to others, somewhat superficial. This is unavoidable, as our knowledge of the details of the evolution of metabolism is at best slim. However, by piecing together aspects of the properties and history of the Earth and coupling these with what we know of today's metabolism, it is possible to at least frame several different hypotheses that, with time, should be possible to test and modify so that the next writing of this chapter might contain some intellectual entrees and not just the appetizers. Any discussion of metabolic evolution must occur in concert with a consideration of the Earth - the understanding of the forces that drove the co-evolution of life and Earth can be achieved only by considering them together. This theme will pervade this chapter, and any real understanding of the evolution of metabolism must be inexorably coupled to, and consistent with, the geological record of the Earth.The first aspect of evolution concerns the metabolic participants as we know them now (i.e., a definition of metabolic diversity), and the second concerns the sequence of events that have led to this remarkable metabolic diversity. The first part is fairly straightforward: a discussion of the domains of life, and the metabolic achievements that are expressed in the various domains, and relating metabolism to biogeochemical processes whenever possible. The second part is much more problematic. While it is possible to make up nearly any story regarding the evolution of metabolism (and nearly all have been attempted!), the starting point of life is not known (great debates still rage as to the nature and origin of the first living systems), and it is not a trivial matter to specify the sequence and timing of metabolic innovations. As will be discussed below, genetic and genomic data have revealed that genetic exchange between organisms has been so pervasive that it has essentially uncoupled the evolution of taxonomic groups from the evolution of metabolic processes, thus, obscuring the evolutionary trail with blurred signals. Given these challenges, it may be prudent at this time to admit what we do not know, and lay out the challenges for the coming years.

Nealson, K. H.; Rye, R.

2003-12-01

438

Multiquark evolution in QCD  

SciTech Connect

We present a formalism for the evolution in Q/sub 2/ of multiquark systems as an application of perturbative quantum chromodynamics (QCD) to asymptotic, exclusive nuclear amplitudes. To leading terms in log Q/sup 2/ our formalism is equivalent to solving the renormalization group equations for these amplitudes. Completely antisymmetric multiquark color-singlet represntations are constructed and their evolution is investigated from the one-gluon exchange kernel. We argue that the evolution equation, together with a cluster decomposition, demonstrates a transition from the traditional meson and nucleon degrees of freedom of nuclear physics to quark and gluon degrees of freedom with increasing Q/sup 2/, or at small internucleon separation. As an example, we derive an evolution equation for a completely antisymmetric six-quark distribution amplitude and solve the evolution equation for a deuteron S-wave amplitude. The leading anomalous dimension and the corresponding eigensolution are found for the deuteron in order to predict the asymptotic form of the deuteron distribution amplitude (i.e., light-cone wave function at short distances). The fact that the six-quark state is 80 percent hidden color at small transverse separation implies that the deuteron form factor cannot be described at large Q/sup 2/ by meson-nucleon degrees of freedom alone. Furthermore, since the N-N channel is very suppressed under these conditions, the effective nucleon-nucleon potential is naturally repulsive at short distances. 20 refs.

Ji, C.R.

1985-09-01

439

Etude du champ magnetique dans les nuages moleculaires  

NASA Astrophysics Data System (ADS)

Ce travail est une étude du champ magnétique duns l'environnement circumstellaire des étoiles jeunes. Il a pour origine la certitude qu'avait l'auteur qu'il se devait d'être possible de détecter la présence d'un champ magnétique, et de possiblement le caractériser, par le biais d'observations de profils spectraux d'espèces moléculaires ioniques. Il en découle donc qu'un des buts principaux était de prouver que cela est effectivement possible. La thèse comporte alors des éléments théoriques et expérimentaux qui sont à la fois complémentaires et intimement liés. L'aspect théorique est basé sur l'interaction mutuelle que des particules neutres et chargées peuvent avoir l'une sur l'autre daps un plasma faiblement ionisé comme ceux existants daps les nuages moléculaires sites de formation stellaire. Il appert que la présence d'un champ magnétique a un effet direct sur le comportement des ions (via la force de Lorentz) et indirect sur les molécules neutres (via les nombreuses collisions entre les deux types de particules). Une telle interaction est, comme il est maintenant bien connu, présente dans les premières étapes de la formation dune étoile. Il s'agit bien sûr de la diffusion ambipolaire. Nous montrerons qu'il existe cependant un autre type de diffusion, jusqu'ici inconnue, qui se manifeste plus tard au tours de l'évolution des nuages moléculaires. Celle-ci peut avoir un effet dramatique sur l'apparence des profils spectraux (de rotation moléculaire) des espèces ioniques lorsque comparés à ceux qu'exhibent des espèces neutres coexistantes. Mais pour ce faire, il doit y avoir existence de mouvements organisés (des flots ou jets) de matière ou encore la présence de turbulence dans les régions considérées. Une distribution de vélocité du type maxwellienne ne révèlera pas la présence du champ magnétique. Les observations, qui ont pour but de confirmer la théorie, se situent dans le domaine des longueurs d'ondes millimétriques et sous- millimétriques. Plusieurs espèces moléculaires furent détectées dans un échantillon significatif de nuages moléculaires. L'effet prédit fut confirmé et ce peu importe si les raies observées sont opaques ou transparentes. Dans le dernier chapitre, nous considérerons une application intéressante où nous utiliserons la manifestation de cet effet (ou son manque) pour vérifier l'alignement préférentiel des flots bipolaires, qui accompagnent souvent la présence de proto- étoiles, avec le champ magnétique local.

Houde, Martin

2001-12-01

440

Misconceptions about Evolution and the Mechanisms of Evolution  

NSDL National Science Digital Library

This resource will help teachers deal with common misconceptions about evolution, those that are simple misunderstandings and others that may stem from purposeful attempts to interfere with the teaching of evolution. First, five common misunderstandings about evolution and how it works are examined. They include the origin of life, ladder of progress, randomness of evolution, trying to adapt, and satisfying needs. The next section indicates that evolution explains the history of life and has no other implications. This site also debunks the alleged incompatibility of religion and evolution.

441

Evolution and Christian Faith  

NASA Astrophysics Data System (ADS)

My recent book, Evolution and Christian Faith explores how evolutionary biology can be portrayed from the religious perspective of Christianity. The principal metaphors for evolutionary biology---differential success at breeding and random mutation, probably originate with the dawn of agriculture and clearly occur in the Bible. The central narrative of evolutionary biology can be presented using Biblical passages, providing an account of evolution that is inherently friendly to a Christian perspective. Still, evolutionary biology is far from complete, and problematic areas pertain to species in which the concept of an individual is poorly defined, and to species in which the expression of gender and sexuality depart from Darwin's sexual-selection templates. The present- day controversy in the US about teaching evolution in the schools provides an opportunity to engage the public about science education.

Roughgarden, J. E.

2006-12-01

442

Experimental evolution of multicellularity.  

PubMed

Multicellularity was one of the most significant innovations in the history of life, but its initial evolution remains poorly understood. Using experimental evolution, we show that key steps in this transition could have occurred quickly. We subjected the unicellular yeast Saccharomyces cerevisiae to an environment in which we expected multicellularity to be adaptive. We observed the rapid evolution of clustering genotypes that display a novel multicellular life history characterized by reproduction via multicellular propagules, a juvenile phase, and determinate growth. The multicellular clusters are uniclonal, minimizing within-cluster genetic conflicts of interest. Simple among-cell division of labor rapidly evolved. Early multicellular strains were composed of physiologically similar cells, but these subsequently evolved higher rates of programmed cell death (apoptosis), an adaptation that increases propagule production. These results show that key aspects of multicellular complexity, a subject of central importance to biology, can readily evolve from unicellular eukaryotes. PMID:22307617

Ratcliff, William C; Denison, R Ford; Borrello, Mark; Travisano, Michael

2012-01-17

443

Episodes in insect evolution.  

PubMed

This article derives from a society-wide symposium organized by Timothy Bradley and Adriana Briscoe and presented at the 2009 annual meeting of the Society for Integrative and Comparative Biology in Boston, Massachusetts. David Grimaldi provided the opening presentation in which he outlined the major evolutionary events in the formation and subsequent diversification of the insect clade. This presentation was followed by speakers who detailed the evolutionary history of specific physiological and/or behavioral traits that have caused insects to be both ecologically successful and fascinating as subjects for biological study. These include a review of the evolutionary history of the insects, the origins of flight, osmoregulation, the evolution of tracheal systems, the evolution of color vision, circadian clocks, and the evolution of eusociality. These topics, as covered by the speakers, provide an overview of the pattern and timing of evolutionary diversification and specialization in the group of animals we know as insects. PMID:21665843

Bradley, Timothy J; Briscoe, Adriana D; Brady, Seán G; Contreras, Heidy L; Danforth, Bryan N; Dudley, Robert; Grimaldi, David; Harrison, Jon F; Kaiser, J Alexander; Merlin, Christine; Reppert, Steven M; Vandenbrooks, John M; Yanoviak, Steve P

2009-06-24

444

Why Is Evolution Controversial?  

NSDL National Science Digital Library

These two activities demonstrate to students that although evolutionary theory is accepted by the scientific community as a valid explanation of the history and structure of the living world, its inclusion in public school curricula continues to be controversial for many. Students study the benchmark historical decisions regarding the teaching of evolution, and see how science can influence policy and vice versa. The first activity will help students to better understand the controversy that hinders the teaching of evolution in many classrooms. In the second activity, students examine the famous court case in which John Scopes was fined for teaching evolution in his high school biology class. Each activity has a list of objectives and links to detailed instruction. The lesson also offers links to an assessment rubric, the national science standards for the lesson, and additional activities.

445

Discrimination between evolution operators  

SciTech Connect

Under broad conditions, evolutions due to two different Hamiltonians are shown to lead at some moment to orthogonal states. For two spin-(1/2) systems subject to precession by different magnetic fields the achievement of orthogonalization is demonstrated for every scenario but a special one. This discrimination between evolutions is experimentally much simpler than procedures proposed earlier based on either sequential or parallel application of the unknown unitaries. A lower bound for the orthogonalization time is proposed in terms of the properties of the two Hamiltonians.

Vertesi, T. [Institute of Nuclear Research of the Hungarian Academy of Sciences, H-4001 Debrecen, P.O. Box 51 (Hungary); Englman, R. [Soreq NRC, Yavne 81800 (Israel)

2007-10-15

446

Evolution in Plane Sight  

NSDL National Science Digital Library

In this activity, learners model directed evolution by making paper fly. Learners construct and fly paper airplanes. During the first round, they calculate the average distance the planes fly and then recreate the planes that flew the furthest. Learners repeat this process several times, observe how the average distance of flight changes, and eventually identify the ideal flyer. This activity can be used to introduce learners to genetic random mutations and how scientists are using directed evolution to engineer new proteins with enhanced properties.

Yu, Julie

2009-01-01

447

A Randomized Phase II Study of Immunization With Dendritic Cells Modified With Poxvectors Encoding CEA and MUC1 Compared With the Same Poxvectors Plus GM-CSF for Resected Metastatic Colorectal Cancer.  

PubMed

OBJECTIVE:: To determine whether 1 of 2 vaccines based on dendritic cells (DCs) and poxvectors encoding CEA (carcinoembryonic antigen) and MUC1 (PANVAC) would lengthen survival in patients with resected metastases of colorectal cancer (CRC). BACKGROUND:: Recurrences after complete resections of metastatic CRC remain frequent. Immune responses to CRC are associated with fewer recurrences, suggesting a role for cancer vaccines as adjuvant therapy. Both DCs and poxvectors are potent stimulators of immune responses against cancer antigens. METHODS:: Patients, disease-free after CRC metastasectomy and perioperative chemotherapy (n = 74), were randomized to injections of autologous DCs modified with PANVAC (DC/PANVAC) or PANVAC with per injection GM-CSF (granulocyte-macrophage colony-stimulating factor). Endpoints were recurrence-free survival overall survival, and rate of CEA-specific immune responses. Clinical outcome was compared with that of an unvaccinated, contemporary group of patients who had undergone CRC metastasectomy, received similar perioperative therapy, and would have otherwise been eligible for the study. RESULTS:: Recurrence-free survival at 2 years was similar (47% and 55% for DC/PANVAC and PANVAC/GM-CSF, respectively) (? P = 0.48). At a median follow-up of 35.7 months, there were 2 of 37 deaths in the DC/PANVAC arm and 5 of 37 deaths in the PANVAC/GM-CSF arm. The rate and magnitude of T-cell responses against CEA was statistically similar between study arms. As a group, vaccinated patients had superior survival compared with the contemporary unvaccinated group. CONCLUSIONS:: Both DC and poxvector vaccines have similar activity. Survival was longer for vaccinated patients than for a contemporary unvaccinated group, suggesting that a randomized trial of poxvector vaccinations compared with standard follow-up after metastasectomy is warranted. (NCT00103142). PMID:23657083

Morse, Michael A; Niedzwiecki, Donna; Marshall, John L; Garrett, Christopher; Chang, David Z; Aklilu, Mebea; Crocenzi, Todd S; Cole, David J; Dessureault, Sophie; Hobeika, Amy C; Osada, Takuya; Onaitis, Mark; Clary, Bryan M; Hsu, David; Devi, Gayathri R; Bulusu, Anuradha; Annechiarico, Robert P; Chadaram, Vijaya; Clay, Timothy M; Lyerly, H Kim

2013-05-01

448

A Pilot Study to Evaluate the Safety and Clinical Outcomes of Vaccination with Recombinant CEA-MUC-1-TRICOM (PANVAC) Poxviral-based Vaccines in Patients with Metastatic Carcinoma  

PubMed Central

Purpose: Poxviral vectors have a proven safety record and can be used to incorporate multiple transgenes. Prior clinical trials with poxviral vaccines have shown that immunologic tolerance to self-antigens can be broken. Carcinoembryonic antigen (CEA) and MUC-1 are overexpressed in a substantial proportion of common solid carcinomas. The primary endpoint of this study was vaccine safety, with immunologic and clinical responses as secondary endpoints. Experimental Design: We report here a pilot study of 25 patients treated with a poxviral vaccine regimen consisting of the genes for CEA and MUC-1, along with a triad of costimulatory molecules (TRICOM, composed of B7.1, ICAM-1, and LFA-3) engineered into vaccinia (PANVAC-V) as a prime and fowlpox (PANVAC-F) as booster vaccinations. Results: The vaccine was well-tolerated. Apart from injection-site reaction, no grade II or greater toxicity was seen in more than 2% of the cycles. Immune responses to MUC-1 and/or CEA were seen following vaccine in 9 of 16 patients tested. A patient with clear cell ovarian cancer and symptomatic ascites had a durable (18-month) clinical response radiographically and biochemically, and one breast cancer patient had a confirmed decrease of > 20% in the size of large liver metastasis. Conclusions: This vaccine strategy appears to be safe, is associated with both CD8 and CD4 immune responses, and has shown evidence of clinical activity. Further trials with this agent, either alone or in combination with immunopotentiating and other therapeutic agents, are warranted.

Gulley, James L.; Arlen, Philip M.; Tsang, Kwong-Yok; Yokokawa, Junko; Palena, Claudia; Poole, Diane J.; Remondo, Cinzia; Cereda, Vittore; Jones, Jacquin L.; Pazdur, Mary P.; Higgins, Jack P.; Hodge, James W.; Steinberg, Seth M.; Kotz, Herbert; Dahut, William L.; Schlom, Jeffrey

2009-01-01

449

Aspect Reglement du Crashworthiness (Regulatory Aspect of Crashworthiness).  

National Technical Information Service (NTIS)

Aircraft crashworthiness is examined from the perspective of safety and regulation. The past and anticipated evolution of crash-related regulations is described. Two main areas of regulatory concern for the future are identified and discussed: acceleratio...

P. J. Rabourdin

1988-01-01

450

Appel pour une allocation intelligente dans le financement du syst?me de sant? au Cameroun  

PubMed Central

Le Cameroun utilise un système de budgétisation historique et une approche «top-down» pour allouer ses ressources de santé publique. Cependant, le pays compte 175 districts de santé dont les fortes disparités de nature épidémiologique, économique, géographique et culturelle, devraient être prises en compte pour réduire les iniquités en matière de sante publique. Comment comprendre alors que dans ces conditions, le budget des administrations publiques alloué aux différents districts de santé au Cameroun soit quasi identique alors que les défis sont si différents? L'inefficience allocative (mauvaise attribution du budget) générée par un tel système conduit vraisemblablement à une inefficience technique (mauvaise utilisation du budget). Pour la marche vers l'atteinte des objectifs du millénaire en matière de sante, il est impératif et urgent que les décideurs du secteur de la santé allouent de manière intelligente les ressources dans le système de santé.

Sieleunou, Isidore

2011-01-01

451

ON NONLINEAR EQUATIONS OF THE FORM F(x,\\, u,\\, Du,\\, \\Delta u) = 0  

NASA Astrophysics Data System (ADS)

The Dirichlet problem for equations of the form F(x,\\, u,\\, Du,\\, \\Delta u) = 0 and also the initial boundary value problem for a parabolic equation with a nonlinearity are studied.Bibliography: 11 titles.

Soltanov, K. N.

1995-02-01

452

Technology Demonstration Summary, DuPont/Oberlin Microfiltration System, Palmerton, Pennsylvania. April-May 1992.  

National Technical Information Service (NTIS)

In April and May 1990, the U.S. Environmental Protection Agency (EPA), under the Superfund Innovative Technology Evaluation (SITE) program, demonstrated DuPont/Oberlin's microfiltration system at the Palmerton Zinc Superfund (PZS) site in Palmerton, Penns...

1992-01-01

453

Étude à basse température de la magnétorésistance du polyparaphénylène implanté  

NASA Astrophysics Data System (ADS)

The magnetoresistance of implanted polyparaphenylene films (E = 30 keV, 1015 ions/cm2 < D < 5× 1016 ions/cm^2) is negative in the low temperature range, whereas its sign is positive for higher temperature when the fluence is sufficiently low; the negative component is attributed to localized states which appear during implantation with high fluence. La magnétorésistance MR de films de polyparaphénylène implantés avec des ions césium de 30 keV à différentes fluences D (1015 ions/cm2 < D < 5×1016ions/cm^2) présente un signe négatif à basse température alors qu'un signe positif apparaît du côté des températures plus élevées lorsque la fluence est suffisamment petite ; la composante négative de MR est attribuée à des états fortement localisés qui sont favorisés par une fluence élevée.

Bellati, A.; Moliton, A.; Lucas, B.; Guille, B.; François, B.

1998-06-01

454

Consonants in Cri du chat syndrome: a case study.  

PubMed

This article reports on a longitudinal case study of consonant productions in one Norwegian girl with Cri du chat syndrome from age 4;6 to age 9;4. It was shown that she had many articulation errors throughout the period of observation. Furthermore, these errors were shown to fall into three main categories: (1) errors of differentiation and tuning, (2) errors of coordination and sequencing, and (3) missing gestures. Also, omissions of segments were reported to be frequent. In sum, the consonant productions by this girl were found to be both delayed and deviant, as compared to normally developing children. The number of errors, however, decreased as she grew older, resulting in more accurate renditions of the target words. PMID:17949737

Kristoffersen, Kristian Emil

2007-09-06

455

Past tense morphology in Cri du chat syndrome: experimental evidence.  

PubMed

It has been observed that persons with Cri du chat syndrome (CDCS) have poor language production. However, very few studies have addressed the question whether all aspects of language production are equally afflicted, or whether there are differences between for instance phonological and morphological abilities. The present study was aimed at investigating to what extent persons with CDCS inflect verbs, and, if so, which inflectional patterns in the target language they make use of, and further what kinds of inflectional errors they make. We compared the performance of three subjects (aged 11, 15 and 22) with CDCS on a past tense elicitation task. We found that all three subjects inflected verbs. The number of correct responses, however, varied from 28% to 53%. The majority of errors were over-generalizations, imitation of input, no response and substitution by semantically related verbs. PMID:18415740

Wium, Kristin; Kristoffersen, Kristian Emil

456

Etude numerique du sillage tourbillonnaire d'une eolienne  

NASA Astrophysics Data System (ADS)

Cette these formalise le concept de la surface actuatrice (SA) et en presente l'implantation dans deux methodes de mecanique des fluides assistee par ordinateur (CFD) bidimensionnelle (2D) et tridimensionnelle (3D), la validation et l'application au probleme de modelisation du sillage tourbillonnaire d'une eolienne. En termes cinetiques, une SA est une nappe tourbillonnaire qui resulte en une discontinuite de vitesse tandis qu'en termes dynamiques, elle est associee a un systeme de forces dont la composante dans la direction normale a la SA resulte en une discontinuite de pression. Les methodes CFD utilisees sont des methodes aux volumes finis, adaptees pour prendre en compte l'action de la SA sur l'ecoulement. L'approche de la SA est validee pour des problemes 2D: aile infinie et disque actuateur, ainsi que pour le probleme 3D de l'aile en translation (aile effilee), avant d'etre appliquee a plusieurs eoliennes.

Sibuet Watters, Christophe

457

Évaluation du potentiel électrique à la surface des dispositifs enrobés  

NASA Astrophysics Data System (ADS)

We present an iterative method for the determination of the potential map of the conducting skin coating on the surface of cast resin electrical devices. The efficiency of the procedure is shown on an exactly solvable case (bus bar). For complex devices, it is shown that the original 3D problem often degenerates into two standard 2D resolutions and one iteration. This point is illustrated with a one-phase Cast Resin Transformer. On propose une méthode itérative pour déterminer le potentiel du revêtement conducteur d'un dispositif électrique enrobé dans une résine isolante. L'efficacité de la procédure est validée sur un cas analytiquement soluble (jeux de barre). On montrera en particulier que le problème initial, typiquement 3D, se laisse souvent décomposer en deux problèmes canoniques 2D et que le processus converge dès la première itération. L'utilisation de cette méthode sera illustrée sur un transformateur monophasé enrobé.

Mazauric, V. G.; Segarceanu, G. N.

1998-04-01

458

Neurological abnormalities in the `cri-du-chat' syndrome 1  

PubMed Central

An unusual case of the cri-du-chat syndrome is described in a 6½ year old boy, who, as well as attacks of stridor and choking, showed disorders of spatial perception and cerebellar signs in the form of nystagmus, clumsiness of the hands, and ataxia. Pyramidal signs were also present. He was only mildly retarded mentally. Psychological testing showed that he had a severe deficit for number processing, and also constructional apraxia. Surprisingly, his vocabulary was quite good, as was his reading capacity. Chromosome analysis showed a very small deletion of the short arm of the group B chromosome. In infancy this diagnosis may be suspected because of the high-pitched cry and attacks of stridor and choking. In late childhood, when the signs may be only of a neurological disorder, its recognition may be difficult without confirmation from chromosome studies. The neurological features of this disease are reviewed. Images

Colover, Jack; Lucas, Mary; Comley, J. A.; Roe, A. M.

1972-01-01

459

Interprétation cohérente du coefficient de Poisson négatif rapporté dans des multicouches métalliques : rôle du paramètre libre de contrainte  

NASA Astrophysics Data System (ADS)

Elastic properties of multilayers with low period thickness show in some cases anomalies which are generally correlated with structural modifications in individual layers. In the recent past, several studies have evidenced using X-ray diffraction in-plane and out-of-plane strains with the same sign. Some authors have then proposed in the case of W/Ni and Nb/Cu metallic superlattices to use a negative Poisson's ratio. This result is surprising because the value of this coefficient in metals is generally positive. In this article, we introduce a novel interpretation mainly based on the experimental determination by sin^2Psi method of the reference parameter (stress-free lattice parameter) used in strain calculations. Then, we show that the introduction of the bulk parameter instead of stress-free parameter for the reference parameter is an unrealistic assumption in the case of thin films and multilayers (W and Ag/Ni) and may thus lead to wrong results which are then in total disagreement with those obtained by other techniques. Therefore, the elastic anomaly concerning Poisson's ratio which has been reported by some authors in scientific literature do not result from real structure of multilayers but from experimental X-ray diffraction data analysis. Les propriétés élastiques dans certains systèmes multicouches de faible période présentent des anomalies qui sont généralement associées à des modifications des propriétés structurales de chacune des couches. Ainsi, plusieurs études ont mis en évidence par diffraction des rayons X des déformations de même signe dans le plan et selon la normale au plan des couches déposées. Certains auteurs ont alors proposé dans le cas de systèmes métalliques W/Ni et Nb/Cu l'utilisation d'un coefficient de Poisson négatif. Ce résultat est surprenant car la valeur de ce coefficient pour les métaux est généralement positive. Dans cet article, nous présentons une nouvelle interprétation reposant sur la détermination expérimentale par la méthode des sin^2Psi de la référence (paramètre libre de contrainte) servant de base au calcul des déformations. Nous montrons alors que l'introduction du paramètre du matériau massif comme référence est une hypothèse irréaliste dans le cas des films minces et multicouches (W et Ag/Ni) qui peut conduire à des résultats erronés et en total désaccord avec ceux obtenus par d'autres techniques. Ainsi, l'anomalie élastique au niveau du coefficient de Poisson soulevée par certains auteurs dans la littérature n'est pas imputable à la structure elle-même mais à l'analyse qui est faite des données expérimentales obtenues par diffraction des rayons X.

Badawi, K. F.; Goudeau, Ph.; Durand, N.

1998-04-01

460

Topical anti-inflammatory activity of DuP 654, a 2-substituted 1-naphthol  

Microsoft Academic Search

Recent work suggests that one of the common biochemical characteristics of skin inflammatory diseases such as psoriasis is altered arachidonic acid metabolism with elevated levels of prostaglandins and leukotrienes. DuP 654, a 2-substituted 1-naphthol, is an exceptionally potent inhibitor of 5-lipoxygenase. DuP 654 was tested in various models of skin inflammation and was found to be potent at inhibiting edema

R. R. Harris; D. G. Batt; W. Galbraith; N. R. Ackerman

1989-01-01

461

Replacing the Father: W. E. B. Du Bois' Reflections on George Washington's Birthday  

Microsoft Academic Search

Washington is not among the representative white men in Du Bois’s canon. Du Bois neither uses him as a satiric stand-in for Anglo-Saxon civilization, as he does Jefferson Davis, nor does he consider Washington an imperfect great man of stature as Abraham Lincoln. And since Washington is not a living president, there are no “open letters” to him of the

Roumiana Velikova

2006-01-01

462

L'habitat du Nord - Pas-de-Calais : au-delà des clichés  

Microsoft Academic Search

[fre] L'habitat du Nord - Pas-de-Calais : au-delà des clichés . La prédominance de la maison individuelle, caractéristique des villes de l'Europe du Nord-Ouest, situe le Nord - Pas-de-Calais à part des autres régions. L'habitat y reste cependant très diversifié. Les bassins industriels formés de l'ex-bassin minier et de la vallée de la Sambre, sites des cités ouvrières, héritage de

Richard Merlen; Marie-Michelle Legrand

1995-01-01

463

Unusual ocular findings in an infant with cri-du-chat syndrome  

Microsoft Academic Search

A newborn male with cri-du-chat syndrome, congenital nuclear cataracts, microspherophakia, and probably ectopic lenses is reported. Microspherophakia in cri-du-chat syndrome has not been previously described. The congenital cataracts were inherited from his mother who had a balanced 5;13 translocation; the two events are considered to be coincidental and a possible 'position effect' was excluded, since the other members of her

S Kitsiou-Tzeli; H D Dellagrammaticas; C B Papas; I D Ladas; C S Bartsocas

1983-01-01

464

Wetlands of Argonne National Laboratory-East DuPage County, Illinois  

Microsoft Academic Search

Jurisdictional wetlands of the Argonne National Laboratory-East (ANL-E) site in DuPage County, Illinois, were delineated in the summer and autumn of 1993 in accordance with the 1987 US Army Corps of Engineers methodology. Potential wetland sites with an area greater than 500 m² (0.05 ha [0.124 acre]) were identified for delineation on the basis of aerial photographs, the DuPage County

R. A. Van Lonkhuyzen; K. E. LaGory

1994-01-01

465

La contibution du patrimoine au développement local : enjeux et limites de sa mesure  

Microsoft Academic Search

Mesurer la contribution du patrimoine au développement local se heurte à de nombreuses difficultés. Elles proviennent de la nature collective du patrimoine, un construit social, mais aussi de la diversité des territoires. or cette mesure est l'objet de forts enjeux politiques issus de la variété des acteurs, source de conflits. Cette communication se termine par la présentation d'une grille n'analyse

Michel Vernières

2012-01-01

466

Une approche endoscopique du travail de groupe: l'Abaque de Régnier  

Microsoft Academic Search

Résumé  L'Abaque de Régnier repose sur la fusion d'un système logique et d'une représentation statistique. L'image en mosaïque organise\\u000a la discussion avec expression préalable de chacun par une décision colorée. La carte obtenue peut être rendue plus lisible\\u000a par traitement de l'information. La gestion du temps de discussion est optimisée par le diagnostic visuel, véritable endoscopie\\u000a du groupe.

F. Régnier

1978-01-01

467

Signature of Electron Capture in Iron-rich Ejecta of SN 2003du  

Microsoft Academic Search

Late-time near-infrared and optical spectra of the normal-bright Type Ia supernova 2003du about 300 days after the explosion are presented. At this late epoch, the emission profiles of well-isolated [Fe II] lines (in particular that of the strong 1.644 mum feature) trace out the global kinematic distribution of radioactive material in the expanding supernova ejecta. In SN 2003du, the 1.644

Peter Höflich; Christopher L. Gerardy; Ken'ichi Nomoto; Kentaro Motohara; Robert A. Fesen; Keiichi Maeda; Takuya Ohkubo; Nozomu Tominaga

2004-01-01

468

De l'analyse juridique à l'évaluation économique comparée du droit des contrats publics  

Microsoft Academic Search

L'article présente les résultats d'une évaluation économique comparée du droit des contrats publics et de l'équilibre financier entre cocontractants . L'étude porte sur cinq pays : quatre pays membres de l'Union européenne (l'Allemagne, l'Espagne, la France, le Royaume-Uni) et les Etats-Unis. A la différence d'autres domaines qui ressortissent de l'activité économique du secteur privé (création d'entreprise, procédures collectives, embauche et

Thierry Kirat; Laurent Vidal; André Delion; Dionysios Kelesidis; Frédéric Marty; Didier Uri

2007-01-01

469

Emploi et marchés du travail d'un secteur : quelles comparaisons internationales ?  

Microsoft Academic Search

[fre] Emploi et marchés du travail d'un secteur quelles comparaisons internationales ? . S'appuyer sur des comparaisons internationales pour analyser les questions d'emploi et de marchés du travail ne peut se faire que si l'on admet la complexité et la diversité des déterminants de l'emploi et si l'on prend en compte les spécificités des situations nationales. L'assise théorique est d'autant

Jean Gadrey; Florence Jany-Catrice

1998-01-01

470

Influence du Procédé de Contrôle Sur Les Tolérances de Réalisation des Filtres Interférentiels à Bande Etroite  

Microsoft Academic Search

Pour contrôler la formation de couches d'épaisseurs optiques ne égales ou multiples d'une même valeur u0\\/4, on utilise couramment des méthodes optiques. Il est en particulier commode de repérer, au cours de l'évaporation, pour la longueur d'onde de centrage du filtre u0, les extremums du facteur de transmission T. Mais on doit bien distinguer les extremums correspondant à ?T\\/? e=0

E. Pelletier; R. Kowalczyk; A. Fornier

1973-01-01

471

Traitement des Images pour la Reconnaissance de Formes EN Presence de Bruit Dependant DU Signal  

Microsoft Academic Search

En traitement d'images, tres peu de recherches ont jusqu'a present considere le probleme de la reconnaissance de formes en presence de bruit dependant du signal. L'originalite de ce travail reside d'une part dans l'etude de la reconnaissance de formes par correlation, invariante sous translation et invariante simultanement sous rotation et translation, en presence de bruit dependant du signal et, d'autre

Jean-Christophe Terrillon

1994-01-01

472

Situations de consommation anticipées du produit et création d'avantages concurrentiels  

Microsoft Academic Search

Résumé L'objectif de ce papier est de présenter les situations de consommation anticipées du produit comme des outils de gestion que les managers se doivent de privilégier dans leur analyse du comportement des acteurs et, en conséquence, dans leur stratégie d'élaboration d'avantages concurrentiels. A partir d'une étude empirique conduite auprès de 208 acheteurs d'automobiles, nous montrons que les contextes d'utilisation

Jean-François Lemoine

473

Synthetics for the Shah: DuPont and the Challenges to Multinationals in 1970s Iran  

Microsoft Academic Search

In the 1960s and 1970s, the largest U.S. chemical firm, E. I. du Pont de Nemours & Company, established an international presence in synthetic fibers by building plants to make nylon, polyester, and acrylic in Latin America and Europe. DuPont managers also looked to the Middle East, specifically to Iran, which was fast industrializing under Shah Mohammad Reza Pahlavi. The

Regina Lee Blaszczyk

2008-01-01

474

Sur la reponse en frequence du tissu nerveux dans le cortex  

NASA Astrophysics Data System (ADS)

Dans cette These de Physique, nous avons etudie la dependance en frequence du champ electrique du tissu nerveux dans le cortex. Ce champ est aussi designe par "Local field Potential" LFP dans la litterature scientifique. Cette etude est fondee sur la theorie du champ electromagnetisme de Maxwell et sur de l'information tiree de la donne experimentale. Le resultat essentiel de cette These est que la grandeur enorme du temps de relaxation de Maxwell des membranes cellulaires semble etre la cause principale de la dependance en frequence des LFPs. Cette dependance en frequence causee par chaque membrane cellulaire est l'analogue d'un circuit RC ou la resistance R est la resistivite parallele d'une membrane cellulaire, et ou la capacite C est la permittivite electrique de la membrane. L'effet resultant