Science.gov

Sample records for center analytical response

  1. Federal Radiological Monitoring and Assessment Center Analytical Response

    SciTech Connect

    E.C. Nielsen

    2003-04-01

    The Federal Radiological Monitoring and Assessment Center (FRMAC) is authorized by the Federal Radiological Emergency Response Plan to coordinate all off-site radiological response assistance to state and local government s, in the event of a major radiological emergency in the United States. The FRMAC is established by the U.S. Department of Energy, National Nuclear Security Administration, to coordinate all Federal assets involved in conducting a comprehensive program of radiological environmental monitoring, sampling, radioanalysis, quality assurance, and dose assessment. During an emergency response, the initial analytical data is provided by portable field instrumentation. As incident responders scale up their response based on the seriousness of the incident, local analytical assets and mobile laboratories add additional capability and capacity. During the intermediate phase of the response, data quality objectives and measurement quality objectives are more rigorous. These higher objectives will require the use of larger laboratories, with greater capacity and enhanced capabilities. These labs may be geographically distant from the incident, which will increase sample management challenges. This paper addresses emergency radioanalytical capability and capacity and its utilization during FRMAC operations.

  2. SciDAC Visualization and Analytics Center for Enabling Technologies

    SciTech Connect

    Joy, Kenneth I.

    2014-09-14

    This project focuses on leveraging scientific visualization and analytics software technology as an enabling technology for increasing scientific productivity and insight. Advances in computational technology have resulted in an "information big bang," which in turn has created a significant data understanding challenge. This challenge is widely acknowledged to be one of the primary bottlenecks in contemporary science. The vision for our Center is to respond directly to that challenge by adapting, extending, creating when necessary and deploying visualization and data understanding technologies for our science stakeholders. Using an organizational model as a Visualization and Analytics Center for Enabling Technologies (VACET), we are well positioned to be responsive to the needs of a diverse set of scientific stakeholders in a coordinated fashion using a range of visualization, mathematics, statistics, computer and computational science and data management technologies.

  3. Teaching social responsibility in analytical chemistry.

    PubMed

    Valcárcel, M; Christian, G D; Lucena, R

    2013-07-01

    Analytical chemistry is key to the functioning of a modern society. From early days, ethics in measurements have been a concern and that remains today, especially as we have come to rely more on the application of analytical science in many aspects of our lives. The main aim of this Feature is to suggest ways of introducing the topic of social responsibility and its relation to analytical chemistry in undergraduate or graduate chemistry courses. PMID:23617684

  4. Stimuli-responsive materials in analytical separation.

    PubMed

    Lorenzo, Rosa A; Carro, Antonia M; Concheiro, Angel; Alvarez-Lorenzo, Carmen

    2015-07-01

    This review focuses on the fundamentals of stimuli-responsive materials and their applications to three common separation techniques, namely extraction, chromatography, and electrophoresis. Although still little investigated, materials that switch their affinity for the analyte on and off as a function of tiny changes in physical and biochemical variables offer relevant advantages for analyte extraction, concentration, and separation. Temperature and/or pH-responsive polymers in the form of chains or networks, which are dispersed in the sample as free entities or after being grafted onto beads (which may incorporate magnetic cores), enable quantitative capture and/or elution of the analyte under mild conditions and without needing organic solvents. Regarding liquid-chromatography separation, responsive stationary phases enable the implementation of "all-in-water" procedures in which retention times are modulated by means of temperature or pH gradients. Other stimuli that can be externally applied, for example light or magnetic fields, can also be used for efficient extraction or separation of the target substance without altering the composition of the sample matrix. Moreover, stimuli-responsiveness enables straightforward recycling of solid and/or stationary phases for a prolonged lifetime. Improved understanding of the phase transitions of stimuli-responsive materials and design of suitable formats for analytical applications should enable wider and more successful application of stimuli-responsive materials in analytical separations. PMID:25910881

  5. User-Centered Evaluation of Technosocial Predictive Analytics

    SciTech Connect

    Scholtz, Jean C.; Whiting, Mark A.

    2009-03-23

    In today’s technology filled world, it is absolutely essential to show the utility of new software, especially software that brings entirely new capabilities to potential users. In the case of technosocial predictive analytics, researchers are developing software capabilities to augment human reasoning and cognition. Getting acceptance and buy-in from analysts and decision makers will not be an easy task. In this position paper, we discuss an approach we are taking for user-centered evaluation that we believe will result in adoption of technosocial predictive software by the intelligence community.

  6. User-Centered Evaluation of Technosocial Predictive Analytic Systems

    SciTech Connect

    Scholtz, Jean; Whiting, Mark A.

    2009-03-23

    In today’s technology filled world, it is absolutely essential to show the utility of new software, especially software that brings entirely new capabilities to potential users. In the case of technosocial predictive analytics, researchers are developing software capabilities to augment human reasoning and cognition. Getting acceptance and buy-in from analysts and decision makers will not be an easy task. In this position paper, we discuss an approach we are taking for user-centered evaluation that we believe will result in facilitating the adoption of technosocial predictive software by the intelligence community.

  7. Analytical derivation of DC SQUID response

    NASA Astrophysics Data System (ADS)

    Soloviev, I. I.; Klenov, N. V.; Schegolev, A. E.; Bakurskiy, S. V.; Kupriyanov, M. Yu

    2016-09-01

    We consider voltage and current response formation in DC superconducting quantum interference device (SQUID) with overdamped Josephson junctions in resistive and superconducting state in the context of a resistively shunted junction (RSJ) model. For simplicity we neglect the junction capacitance and the noise effect. Explicit expressions for the responses in resistive state were obtained for a SQUID which is symmetrical with respect to bias current injection point. Normalized SQUID inductance l=2{{eI}}{{c}}L/{\\hslash } (where I c is the critical current of Josephson junction, L is the SQUID inductance, e is the electron charge and ℏ is the Planck constant) was assumed to be within the range l ≤ 1, subsequently expanded up to l≈ 7 using two fitting parameters. SQUID current response in the superconducting state was considered for arbitrary value of the inductance. The impact of small technological spread of parameters relevant to low-temperature superconductor (LTS) technology was studied, using a generalization of the developed analytical approach, for the case of a small difference of critical currents and shunt resistances of the Josephson junctions, and inequality of SQUID inductive shoulders for both resistive and superconducting states. Comparison with numerical calculation results shows that developed analytical expressions can be used in practical LTS SQUIDs and SQUID-based circuits design, e.g. large serial SQIF, drastically decreasing the time of simulation.

  8. SciDAC Visualization and Analytics Center for EnablingTechnologies

    SciTech Connect

    Bethel, E. Wes; Johnson, Chris; Joy, Ken; Ahern, Sean; Pascucci,Valerio; Childs, Hank; Cohen, Jonathan; Duchaineau, Mark; Hamann, Bernd; Hansen, Charles; Laney, Dan; Lindstrom, Peter; Meredith, Jermey; Ostrouchov, George; Parker, Steven; Silva, Claudio; Sanderson, Allen; Tricoche, Xavier.

    2007-06-30

    The Visualization and Analytics Center for EnablingTechnologies (VACET) focuses on leveraging scientific visualization andanalytics software technology as an enabling technology for increasingscientific productivity and insight. Advances in computational technologyhave resulted in an 'information big bang,' which in turn has created asignificant data understanding challenge. This challenge is widelyacknowledged to be one of the primary bottlenecks in contemporaryscience. The vision of VACET is to adapt, extend, create when necessary,and deploy visual data analysis solutions that are responsive to theneeds of DOE'scomputational and experimental scientists. Our center isengineered to be directly responsive to those needs and to deliversolutions for use in DOE's large open computing facilities. The researchand development directly target data understanding problems provided byour scientific application stakeholders. VACET draws from a diverse setof visualization technology ranging from production quality applicationsand application frameworks to state-of-the-art algorithms forvisualization, analysis, analytics, data manipulation, and datamanagement.

  9. VACET: Proposed SciDAC2 Visualization and Analytics Center forEnabling Technologies

    SciTech Connect

    Bethel, W.; Johnson, Chris; Hansen, Charles; Parker, Steve; Sanderson, Allen; Silva, Claudio; Tricoche, Xavier; Pascucci, Valerio; Childs, Hank; Cohen, Jonathon; Duchaineau, Mark; Laney, Dan; Lindstrom,Peter; Ahern, Sean; Meredith, Jeremy; Ostrouchov, George; Joy, Ken; Hamann, Bernd

    2006-06-19

    This paper accompanies a poster that is being presented atthe SciDAC 2006 meeting in Denver, CO. This project focuses on leveragingscientific visualization and analytics software technology as an enablingtechnology for increasing scientific productivity and insight. Advancesincomputational technology have resultedin an "information big bang,"which in turn has createda significant data understanding challenge. Thischallenge is widely acknowledged to be one of the primary bottlenecks incontemporary science. The vision for our Center is to respond directly tothat challenge by adapting, extending, creating when necessary anddeploying visualization and data understanding technologies for ourscience stakeholders. Using an organizational model as a Visualizationand Analytics Center for Enabling Technologies (VACET), we are wellpositioned to be responsive to the needs of a diverse set of scientificstakeholders in a coordinated fashion using a range of visualization,mathematics, statistics, computer and computational science and datamanagement technologies.

  10. Analytical response function for planar Ge detectors

    NASA Astrophysics Data System (ADS)

    García-Alvarez, Juan A.; Maidana, Nora L.; Vanin, Vito R.; Fernández-Varea, José M.

    2016-04-01

    We model the response function (RF) of planar HPGe x-ray spectrometers for photon energies between around 10 keV and 100 keV. The RF is based on the proposal of Seltzer [1981. Nucl. Instrum. Methods 188, 133-151] and takes into account the full-energy absorption in the Ge active volume, the escape of Ge Kα and Kβ x-rays and the escape of photons after one Compton interaction. The relativistic impulse approximation is employed instead of the Klein-Nishina formula to describe incoherent photon scattering in the Ge crystal. We also incorporate a simple model for the continuous component of the spectrum produced by the escape of photo-electrons from the active volume. In our calculations we include external interaction contributions to the RF: (i) the incoherent scattering effects caused by the detector's Be window and (ii) the spectrum produced by photo-electrons emitted in the Ge dead layer that reach the active volume. The analytical RF model is compared with pulse-height spectra simulated using the PENELOPE Monte Carlo code.

  11. An analytics approach to designing patient centered medical homes.

    PubMed

    Ajorlou, Saeede; Shams, Issac; Yang, Kai

    2015-03-01

    Recently the patient centered medical home (PCMH) model has become a popular team based approach focused on delivering more streamlined care to patients. In current practices of medical homes, a clinical based prediction frame is recommended because it can help match the portfolio capacity of PCMH teams with the actual load generated by a set of patients. Without such balances in clinical supply and demand, issues such as excessive under and over utilization of physicians, long waiting time for receiving the appropriate treatment, and non-continuity of care will eliminate many advantages of the medical home strategy. In this paper, by using the hierarchical generalized linear model with multivariate responses, we develop a clinical workload prediction model for care portfolio demands in a Bayesian framework. The model allows for heterogeneous variances and unstructured covariance matrices for nested random effects that arise through complex hierarchical care systems. We show that using a multivariate approach substantially enhances the precision of workload predictions at both primary and non primary care levels. We also demonstrate that care demands depend not only on patient demographics but also on other utilization factors, such as length of stay. Our analyses of a recent data from Veteran Health Administration further indicate that risk adjustment for patient health conditions can considerably improve the prediction power of the model. PMID:24942633

  12. Deep Center Analytical Foundations v. 1.0

    Energy Science and Technology Software Center (ESTSC)

    2006-02-15

    DCAF is a software library containing analytic functions for encoding, mapping, structuring, and providing access to relations among a collection of entities and deriving attribute and structural features for the purposes of providing an interpretable representation of the information within a collection.

  13. An Improved Analytic Model for Microdosimeter Response

    NASA Technical Reports Server (NTRS)

    Shinn, Judy L.; Wilson, John W.; Xapsos, Michael A.

    2001-01-01

    An analytic model used to predict energy deposition fluctuations in a microvolume by ions through direct events is improved to include indirect delta ray events. The new model can now account for the increase in flux at low lineal energy when the ions are of very high energy. Good agreement is obtained between the calculated results and available data for laboratory ion beams. Comparison of GCR (galactic cosmic ray) flux between Shuttle TEPC (tissue equivalent proportional counter) flight data and current calculations draws a different assessment of developmental work required for the GCR transport code (HZETRN) than previously concluded.

  14. Wind Turbine Response to Analytic Inflow Vortex Parameters Variation: Preprint

    SciTech Connect

    Hand, M. M.; Robinson, M. C.; Balas, M. J.

    2003-11-01

    As larger wind turbines are placed on taller towers, rotors frequently operate in atmospheric conditions that support organized, coherent turbulent structures. It is hypothesized that these structures have a detrimental impact on the blade fatigue life experienced by the wind turbine. These structures are extremely difficult to identify with sophisticated anemometry such as ultra-sonic anemometers. In order to ascertain the idealized worst-case scenario for vortical inflow structures impinging on a wind turbine rotor, we created a simple, analytic vortex model. The Rankine vortex model assumes the vortex core undergoes solid body rotation to avoid a singularity at the vortex center and is surrounded by a 2-dimensional potential flow field. Using the wind turbine as a sensor and the FAST wind turbine dynamics code with limited degrees of freedom, we determined the aerodynamic loads imparted to the wind turbine by the vortex structure. The size, strength, rotational direction, plan e of rotation, and location of the vortex were varied over a wide range of operating parameters. We identified the vortex conformation with the most significant effect on blade root bending moment cycle amplitude. Vortices with radii on the scale of the rotor diameter or smaller caused blade root bending moment cyclic amplitudes that lead to reduced fatigue life. The rotational orientation, clockwise or counter-clockwise produces little difference in the bending moment response. Vortices in the XZ plane produce bending moment amplitudes significantly greater than vortices in the YZ plane. The response to vortices in the inflow is similar for both 2- and 3-blade turbines.

  15. An analytical and experimental study of crack extension in center-notched composites

    NASA Technical Reports Server (NTRS)

    Beuth, Jack L., Jr.; Herakovich, Carl T.

    1987-01-01

    The normal stress ratio theory for crack extension in anisotropic materials is studied analytically and experimentally. The theory is applied within a microscopic-level analysis of a single center notch of arbitrary orientation in a unidirectional composite material. The bulk of the analytical work of this study applies an elasticity solution for an infinite plate with a center line to obtain critical stress and crack growth direction predictions. An elasticity solution for an infinite plate with a center elliptical flaw is also used to obtain qualitative predictions of the location of crack initiation on the border of a rounded notch tip. The analytical portion of the study includes the formulation of a new crack growth theory that includes local shear stress. Normal stress ratio theory predictions are obtained for notched unidirectional tensile coupons and unidirectional Iosipescu shear specimens. These predictions are subsequently compared to experimental results.

  16. SciDAC Visualization and Analytics Center for EnablingTechnology

    SciTech Connect

    Bethel, E. Wes; Johnson, Chris; Joy, Ken; Ahern, Sean; Pascucci,Valerio; Childs, Hank; Cohen, Jonathan; Duchaineau, Mark; Hamann, Bernd; Hansen, Charles; Laney, Dan; Lindstrom, Peter; Meredith, Jeremy; Ostrouchov, George; Parker, Steven; Silva, Claudio; Sanderson, Allen; Tricoche, Xavier

    2006-11-28

    The SciDAC2 Visualization and Analytics Center for EnablingTechnologies (VACET) began operation on 10/1/2006. This document, dated11/27/2006, is the first version of the VACET project management plan. Itwas requested by and delivered to ASCR/DOE. It outlines the Center'saccomplishments in the first six weeks of operation along with broadobjectives for the upcoming future (12-24 months).

  17. Analytical models of optical response in one-dimensional semiconductors

    NASA Astrophysics Data System (ADS)

    Pedersen, Thomas Garm

    2015-09-01

    The quantum mechanical description of the optical properties of crystalline materials typically requires extensive numerical computation. Including excitonic and non-perturbative field effects adds to the complexity. In one dimension, however, the analysis simplifies and optical spectra can be computed exactly. In this paper, we apply the Wannier exciton formalism to derive analytical expressions for the optical response in four cases of increasing complexity. Thus, we start from free carriers and, in turn, switch on electrostatic fields and electron-hole attraction and, finally, analyze the combined influence of these effects. In addition, the optical response of impurity-localized excitons is discussed.

  18. Teacher Center Responses to Teacher Needs.

    ERIC Educational Resources Information Center

    Riley, Roberta D.; Mort, Ken

    1981-01-01

    The intention of this article is to view specific means of meeting teacher needs through Maslow's multiple-factor theory of self-actualization. Under each of Maslow's five headings, a brief explanation of the use of the term and examples of teacher center services fitting under that heading are discussed. (Author)

  19. Responsibility Center Management: Lessons from 25 Years of Decentralized Management.

    ERIC Educational Resources Information Center

    Strauss, Jon C.; Curry, John R.

    Decentralization of authority is a natural act in universities, but decentralization of responsibility is not. A problem faced by universities is the decoupling of academic authority from financial responsibility. The solution proposed in this book for the coupling is Responsibility Center Management (RCM), also called Revenue Responsibility…

  20. Analytical and physical modeling program for the NASA Lewis Research Center's Altitude Wind Tunnel (AWT)

    NASA Technical Reports Server (NTRS)

    Abbott, J. M.; Deidrich, J. H.; Groeneweg, J. F.; Povinelli, L. A.; Reid, L.; Reinmann, J. J.; Szuch, J. R.

    1985-01-01

    An effort is currently underway at the NASA Lewis Research Center to rehabilitate and extend the capabilities of the Altitude Wind Tunnel (AWT). This extended capability will include a maximum test section Mach number of about 0.9 at an altitude of 55,000 ft and a -20 F stagnation temperature (octagonal test section, 20 ft across the flats). In addition, the AWT will include an icing and acoustic research capability. In order to insure a technically sound design, an AWT modeling program (both analytical and physical) was initiated to provide essential input to the AWT final design process. This paper describes the modeling program, including the rationale and criteria used in program definition, and presents some early program results.

  1. Automating the Analytical Laboratories Section, Lewis Research Center, National Aeronautics and Space Administration: A feasibility study

    NASA Technical Reports Server (NTRS)

    Boyle, W. G.; Barton, G. W.

    1979-01-01

    The feasibility of computerized automation of the Analytical Laboratories Section at NASA's Lewis Research Center was considered. Since that laboratory's duties are not routine, the automation goals were set with that in mind. Four instruments were selected as the most likely automation candidates: an atomic absorption spectrophotometer, an emission spectrometer, an X-ray fluorescence spectrometer, and an X-ray diffraction unit. Two options for computer automation were described: a time-shared central computer and a system with microcomputers for each instrument connected to a central computer. A third option, presented for future planning, expands the microcomputer version. Costs and benefits for each option were considered. It was concluded that the microcomputer version best fits the goals and duties of the laboratory and that such an automted system is needed to meet the laboratory's future requirements.

  2. Hazardous Materials Management and Emergency Response training Center needs assessment

    SciTech Connect

    McGinnis, K.A.; Bolton, P.A.; Robinson, R.K.

    1993-09-01

    For the Hanford Site to provide high-quality training using simulated job-site situations to prepare the 4,000 Site workers and 500 emergency responders for known and unknown hazards a Hazardous Materials Management and Emergency Response Training Center is needed. The center will focus on providing classroom lecture as well as hands-on, realistic training. The establishment of the center will create a partnership among the US Department of Energy; its contractors; labor; local, state, and tribal governments; and Xavier and Tulane Universities of Louisiana. This report presents the background, history, need, benefits, and associated costs of the proposed center.

  3. GIS in the World Trade Center Response: 10 Years after

    NASA Astrophysics Data System (ADS)

    Kevany, M.

    2011-08-01

    The World Trade Center attack of 9/11/01 and the response brought major attention to GIS as a valuable tool for supporting emergency management and response. That attention led to the allocation of considerable resources to the enhancement of GIS. This paper is intended to provide a look back at the events prior to and immediately following the attack, review of GIS in the response and recovery efforts, explore the emergence of GIS in Emergency Management from the impetus generated in the NYC experience and explore the challenges yet facing the use of GIS in emergency management. The author participated in the WTC response as a member of the Emergency Mapping and Data Center component of the Emergency Operations Center through which the response was managed.

  4. COMPARISON OF RESPONSE OF 9977 TEST PACKAGES TO ANALYTICAL RESULTS

    SciTech Connect

    Smith, A; Tsu-Te Wu, T

    2007-12-05

    Each of the hypothetical accident test cases for the 9977 prototypes was included in the battery of finite element structural analyses performed for the package. Comparison of the experimental and analytical results provides a means of confirming that the analytical model correctly represents the physical behavior of the package. The ability of the analytical model to correctly predict the performance of the foam overpack material for the crush test is of particular interest. The dissipation of energy in the crushing process determines the deceleration of the package upon impact and the duration of the impact. In addition, if the analytical model correctly models the foam behavior, the predicted deformation of the package will match that measured on the test articles. This study compares the deformations of the test packages with the analytical predictions. In addition, the impact acceleration and impact duration for the test articles are compared with those predicted by the analyses.

  5. Wind turbine response to parameter variation of analytic inflow vortices

    NASA Astrophysics Data System (ADS)

    Hand, M. Maureen; Robinson, Michael C.; Balas, Mark J.

    2006-05-01

    As larger wind turbines are placed on taller towers, rotors frequently operate in atmospheric conditions that support organized, coherent turbulent structures. It is hypothesized that these structures have a detrimental impact on the blade fatigue life experienced by the wind turbine. These structures are extremely difficult to identify with sophisticated anemometry such as ultrasonic anemometers. This study was performed to identify the vortex characteristics that contribute to high-amplitude cyclic blade loads, assuming that these vortices exist under certain atmospheric conditions. This study does not attempt to demonstrate the existence of these coherent turbulent structures. In order to ascertain the idealized worst-case scenario for vortical inflow structures impinging on a wind turbine rotor, we created a simple, analytic vortex model. The Rankine vortex model assumes that the vortex core undergoes solid body rotation to avoid a singularity at the vortex centre and is surrounded by a two-dimensional potential flow field. Using the wind turbine as a sensor and the FAST wind turbine dynamics code with limited degrees of freedom, we determined the aerodynamic loads imparted to the wind turbine by the vortex structure. We varied the size, strength, rotational direction, plane of rotation, and location of the vortex over a wide range of operating parameters. We identified the vortex conformation with the most significant effect on the blade root bending moment cyclic amplitude. Vortices with radii on the scale of the rotor diameter or smaller caused blade root bending moment cyclic amplitudes that contribute to high damage density. The rotational orientation, clockwise or counter-clockwise, produces little difference in the bending moment response. Vortices in the XZ plane produce bending moment amplitudes significantly greater than vortices in the YZ plane. Published in 2005 by John Wiley & Sons, Ltd.Received: 9 April 2004; Revised: 14 March 2005; Accepted: 19

  6. Measurement of Chern numbers through center-of-mass responses

    NASA Astrophysics Data System (ADS)

    Price, H. M.; Zilberberg, O.; Ozawa, T.; Carusotto, I.; Goldman, N.

    2016-06-01

    Probing the center-of-mass of an ultracold atomic cloud can be used to measure Chern numbers, the topological invariants underlying the quantum Hall effects. In this work, we show how such center-of-mass observables can have a much richer dependence on topological invariants than previously discussed. In fact, the response of the center of mass depends not only on the current density, typically measured in a solid-state system, but also on the particle density, which itself can be sensitive to the topology of the band structure. We apply a semiclassical approach, supported by numerical simulations, to highlight the key differences between center-of-mass responses and more standard conductivity measurements. We illustrate this by analyzing both the two- and four-dimensional quantum Hall effects. These results have important implications for experiments in engineered topological systems, such as ultracold gases and photonics.

  7. DOE's SciDAC Visualization and Analytics Center for EnablingTechnologies -- Strategy for Petascale Visual Data Analysis Success

    SciTech Connect

    Bethel, E Wes; Johnson, Chris; Aragon, Cecilia; Rubel, Oliver; Weber, Gunther; Pascucci, Valerio; Childs, Hank; Bremer, Peer-Timo; Whitlock, Brad; Ahern, Sean; Meredith, Jeremey; Ostrouchov, George; Joy, Ken; Hamann, Bernd; Garth, Christoph; Cole, Martin; Hansen, Charles; Parker, Steven; Sanderson, Allen; Silva, Claudio; Tricoche, Xavier

    2007-10-01

    The focus of this article is on how one group of researchersthe DOE SciDAC Visualization and Analytics Center for EnablingTechnologies (VACET) is tackling the daunting task of enabling knowledgediscovery through visualization and analytics on some of the world slargest and most complex datasets and on some of the world's largestcomputational platforms. As a Center for Enabling Technology, VACET smission is the creation of usable, production-quality visualization andknowledge discovery software infrastructure that runs on large, parallelcomputer systems at DOE's Open Computing facilities and that providessolutions to challenging visual data exploration and knowledge discoveryneeds of modern science, particularly the DOE sciencecommunity.

  8. Description of a Generalized Analytical Model for the Micro-dosimeter Response

    NASA Technical Reports Server (NTRS)

    Badavi, Francis F.; Stewart-Sloan, Charlotte R.; Xapsos, Michael A.; Shinn, Judy L.; Wilson, John W.; Hunter, Abigail

    2007-01-01

    An analytical prediction capability for space radiation in Low Earth Orbit (LEO), correlated with the Space Transportation System (STS) Shuttle Tissue Equivalent Proportional Counter (TEPC) measurements, is presented. The model takes into consideration the energy loss straggling and chord length distribution of the TEPC detector, and is capable of predicting energy deposition fluctuations in a micro-volume by incoming ions through both direct and indirect ionic events. The charged particle transport calculations correlated with STS 56, 51, 110 and 114 flights are accomplished by utilizing the most recent version (2005) of the Langley Research Center (LaRC) deterministic ionized particle transport code High charge (Z) and Energy TRaNsport WZETRN), which has been extensively validated with laboratory beam measurements and available space flight data. The agreement between the TEPC model prediction (response function) and the TEPC measured differential and integral spectra in lineal energy (y) domain is promising.

  9. The germinal center antibody response in health and disease

    PubMed Central

    DeFranco, Anthony L.

    2016-01-01

    The germinal center response is the delayed but sustained phase of the antibody response that is responsible for producing high-affinity antibodies of the IgG, IgA and/or IgE isotypes. B cells in the germinal center undergo re-iterative cycles of somatic hypermutation of immunoglobulin gene variable regions, clonal expansion, and Darwinian selection for cells expressing higher-affinity antibody variants. Alternatively, selected B cells can terminally differentiate into long-lived plasma cells or into a broad diversity of mutated memory B cells; the former secrete the improved antibodies to fight an infection and to provide continuing protection from re-infection, whereas the latter may jumpstart immune responses to subsequent infections with related but distinct infecting agents. Our understanding of the molecules involved in the germinal center reaction has been informed by studies of human immunodeficiency patients with selective defects in the production of antibodies. Recent studies have begun to reveal how innate immune recognition via Toll-like receptors can enhance the magnitude and selective properties of the germinal center, leading to more effective control of infection by a subset of viruses. Just as early insights into the nature of the germinal center found application in the development of the highly successful conjugate vaccines, more recent insights may find application in the current efforts to develop new generations of vaccines, including vaccines that can induce broadly protective neutralizing antibodies against influenza virus or HIV-1. PMID:27303636

  10. The Center for Healthy Weight: an academic medical center response to childhood obesity

    PubMed Central

    Robinson, T N; Kemby, K M

    2012-01-01

    Childhood obesity represents a worldwide medical and public health challenge. Academic medical centers cannot avoid the effects of the obesity epidemic, and must adopt strategies for their academic, clinical and public policy responses to childhood obesity. The Center for Healthy Weight at Stanford University and Lucile Packard Children's Hospital at Stanford provides an example and model of one such strategy. The design provides both breadth and depth through six cores: Research, Patient Care, Community Programs, Advocating for Public Policy Change, Training and Professional Education, and the Healthy Hospital Initiative. The Center and its cores are designed to facilitate interdisciplinary collaboration across the university, medical school, children's hospital and surrounding community. The foci of these cores are likely to be relevant to almost any academic medical center's mission and functions. PMID:25089192

  11. Responsibility Center Management: An Assessment of RCM at IUPUI.

    ERIC Educational Resources Information Center

    Robbins, David L.; Rooney, Patrick Michael

    1995-01-01

    Indiana University-Purdue University at Indianapolis is the first public institution to implement Responsibility Center Management (RCM), a comprehensive decentralized, incentive-base financial management system. RCM has strengthened academic planning, budget management, general accountability, and multiyear fiscal planning. Organizational…

  12. 47 CFR 0.192 - Emergency Response Interoperability Center.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... Public Safety and Homeland Security Bureau to develop, recommend, and administer policy goals, objectives... Organization Public Safety and Homeland Security Bureau § 0.192 Emergency Response Interoperability Center. (a... extent permitted by applicable law, the Chief of the Public Safety and Homeland Security Bureau...

  13. 47 CFR 0.192 - Emergency Response Interoperability Center.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... Public Safety and Homeland Security Bureau to develop, recommend, and administer policy goals, objectives... Organization Public Safety and Homeland Security Bureau § 0.192 Emergency Response Interoperability Center. (a... extent permitted by applicable law, the Chief of the Public Safety and Homeland Security Bureau...

  14. On the Use of Factor-Analytic Multinomial Logit Item Response Models to Account for Individual Differences in Response Style

    ERIC Educational Resources Information Center

    Johnson, Timothy R.; Bolt, Daniel M.

    2010-01-01

    Multidimensional item response models are usually implemented to model the relationship between item responses and two or more traits of interest. We show how multidimensional multinomial logit item response models can also be used to account for individual differences in response style. This is done by specifying a factor-analytic model for…

  15. Client-centered home care: balancing between competing responsibilities.

    PubMed

    Schoot, Tineke; Proot, Ireen; Legius, Marja; ter Meulen, Ruud; de Witte, Luc

    2006-11-01

    This study explores and describes the perceptions of nurses with respect to everyday client-centered care. A grounded theory study was conducted with 10 Dutch nurses and auxiliary nurses giving home care to chronically ill clients. Participatory observations and semistructured interviews were held. Nurses perceived roles and responsibilities competing with the role as a responsive professional to the client demand: a critical professional, developer of client competencies, individual, and employee. Strategies in balancing between competing responsibilities were distinguished: pleasing, dialoguing, directing, and detaching. Directing (related to impaired client competencies) and detaching (related to organizational barriers) were also used as second choice strategies. Effectively balancing between competing responsibilities was seen in dialoguing and directing as second choice. Conditions identified related to these strategies are awareness of, and responsibility taking for competing responsibilities. Recommendations for practice concern a care relationship and a dialogue with the client, critical ethical reflection, professional autonomy, self-assertiveness and organizational support. PMID:17056768

  16. Approximate analytical description of the nonaffine response of amorphous solids

    SciTech Connect

    Zaccone, Alessio; Scossa-Romano, Enzo

    2011-05-01

    An approximation scheme for model disordered solids is proposed that leads to the fully analytical evaluation of the elastic constants under explicit account of the inhomogeneity (nonaffinity) of the atomic displacements. The theory is in quantitative agreement with simulations for central-force systems and predicts the vanishing of the shear modulus at the isostatic point with the linear law {mu}{approx}(z-2d), where z is the coordination number. The vanishing of rigidity at the isostatic point is shown to be a consequence of the canceling out of positive affine and negative nonaffine terms.

  17. Federal Radiological Monitoring and Assessment Center: Phase I Response

    SciTech Connect

    C. Riland; D. R. Bowman; R. Lambert; R. Tighe

    1999-09-30

    A Federal Radiological Monitoring and Assessment Center (FRMAC) is established in response to a Lead Federal Agency (LFA) or State request when a radiological emergency is anticipated or has occurred. The FRMAC coordinates the off-site monitoring, assessment, and analysis activities during such an emergency. The FRMAC response is divided into three phases. FRMAC Phase 1 is a rapid, initial-response capability that can interface with Federal or State officials and is designed for a quick response time and rapid radiological data collection and assessment. FRMAC Phase 1 products provide an initial characterization of the radiological situation and information on early health effects to officials responsible for making and implementing protective action decisions.

  18. Technology Transfer Center to Assume Patenting and Licensing Responsibilities | Poster

    Cancer.gov

    The NCI Technology Transfer Center (TTC) is undergoing a reorganization that will bring patenting and licensing responsibilities to the Shady Grove and Frederick offices by October 2015. The reorganization is a result of an effort begun in 2014 by NIH to improve the organizational structure of technology transfer at NIH to meet the rapid rate of change within science, technology, and industry, and to better align the science and laboratory goals with the licensing and patenting process.

  19. NASA Lewis Research Center Workshop on Forced Response in Turbomachinery

    NASA Technical Reports Server (NTRS)

    Stefko, George L. (Compiler); Murthy, Durbha V. (Compiler); Morel, Michael (Compiler); Hoyniak, Dan (Compiler); Gauntner, Jim W. (Compiler)

    1994-01-01

    A summary of the NASA Lewis Research Center (LeRC) Workshop on Forced Response in Turbomachinery in August, 1993 is presented. It was sponsored by the following NASA organizations: Structures, Space Propulsion Technology, and Propulsion Systems Divisions of NASA LeRC and the Aeronautics and Advanced Concepts & Technology Offices of NASA Headquarters. In addition, the workshop was held in conjunction with the GUIde (Government/Industry/Universities) Consortium on Forced Response. The workshop was specifically designed to receive suggestions and comments from industry on current research at NASA LeRC in the area of forced vibratory response of turbomachinery blades which includes both computational and experimental approaches. There were eight presentations and a code demonstration. Major areas of research included aeroelastic response, steady and unsteady fluid dynamics, mistuning, and corresponding experimental work.

  20. Analytical and computational modeling of the mechanical response of polycrystalline and nanocrystalline metals

    NASA Astrophysics Data System (ADS)

    Fu, Hsueh-Hung

    Metallic materials with different grain sizes exhibit vasty differences in their mechanical behavior. For example, the mechanical strength of nanocrystalline materials is superior to those with coarse grain materials. In recent decades, many analytical and experimental efforts have been contributed to this new materials field. In this research, a computational and analytical study of the grain size effect on the behavior of polycrystalline and nanocrystalline copper. A phenomenological constitutive description of this scaling response is discussed and adopted to build the numerical model. Both elastic and plastic anisotropy are included in this investigation. The material is envisaged as a composite, comprised of the grain interior, with flow stress sigmafG, and grain boundary layer, with flow stress sigmafGB. The hardening rates in the grain interior and grain boundary are different as a result of differences in dislocation source densities and interactions. The material is modeled as a monocrystalline core surrounded by a mantle grain boundary with a higher work hardening rate response. The computational predictions of plastic flow as a function of grain size are made incorporating differences of dislocation accumulation rate in grain-boundary regions and grain interiors. To depict the deformation response of face-centered cubic copper, three material models are implemented into an Eulerian finite element hydrocode. In model I, three sets of crystals with hard, medium and soft orientations are randomly embedded in the computational domain; the flow stress is developed for isotropic von Mises plasticity from the experimental data of C23, C26 and C30. In model II, rate dependent crystal plasticity with planar double slip is implemented in the grain interiors to study the nonuniform deformation and localized plastic flow while the mechanical behavior of grain boundaries is defined as in model I. In model III, both the grain interior and grain boundary are modeled

  1. Experimental design and multiple response optimization. Using the desirability function in analytical methods development.

    PubMed

    Candioti, Luciana Vera; De Zan, María M; Cámara, María S; Goicoechea, Héctor C

    2014-06-01

    A review about the application of response surface methodology (RSM) when several responses have to be simultaneously optimized in the field of analytical methods development is presented. Several critical issues like response transformation, multiple response optimization and modeling with least squares and artificial neural networks are discussed. Most recent analytical applications are presented in the context of analytLaboratorio de Control de Calidad de Medicamentos (LCCM), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.C. 242, S3000ZAA Santa Fe, ArgentinaLaboratorio de Control de Calidad de Medicamentos (LCCM), Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, C.C. 242, S3000ZAA Santa Fe, Argentinaical methods development, especially in multiple response optimization procedures using the desirability function. PMID:24767454

  2. Demand Response and Open Automated Demand Response Opportunities for Data Centers

    SciTech Connect

    Ghatikar, Girish; Piette, Mary Ann; Fujita, Sydny; McKane, Aimee; Dudley, Junqiao Han; Radspieler, Anthony; Mares, K.C.; Shroyer, Dave

    2009-12-30

    This study examines data center characteristics, loads, control systems, and technologies to identify demand response (DR) and automated DR (Open Auto-DR) opportunities and challenges. The study was performed in collaboration with technology experts, industrial partners, and data center facility managers and existing research on commercial and industrial DR was collected and analyzed. The results suggest that data centers, with significant and rapidly growing energy use, have significant DR potential. Because data centers are highly automated, they are excellent candidates for Open Auto-DR. 'Non-mission-critical' data centers are the most likely candidates for early adoption of DR. Data center site infrastructure DR strategies have been well studied for other commercial buildings; however, DR strategies for information technology (IT) infrastructure have not been studied extensively. The largest opportunity for DR or load reduction in data centers is in the use of virtualization to reduce IT equipment energy use, which correspondingly reduces facility cooling loads. DR strategies could also be deployed for data center lighting, and heating, ventilation, and air conditioning. Additional studies and demonstrations are needed to quantify benefits to data centers of participating in DR and to address concerns about DR's possible impact on data center performance or quality of service and equipment life span.

  3. Analytical, experimental, and Monte Carlo system response matrix for pinhole SPECT reconstruction

    SciTech Connect

    Aguiar, Pablo; Pino, Francisco; Silva-Rodríguez, Jesús; Pavía, Javier; Ros, Doménec; Ruibal, Álvaro; and others

    2014-03-15

    Purpose: To assess the performance of two approaches to the system response matrix (SRM) calculation in pinhole single photon emission computed tomography (SPECT) reconstruction. Methods: Evaluation was performed using experimental data from a low magnification pinhole SPECT system that consisted of a rotating flat detector with a monolithic scintillator crystal. The SRM was computed following two approaches, which were based on Monte Carlo simulations (MC-SRM) and analytical techniques in combination with an experimental characterization (AE-SRM). The spatial response of the system, obtained by using the two approaches, was compared with experimental data. The effect of the MC-SRM and AE-SRM approaches on the reconstructed image was assessed in terms of image contrast, signal-to-noise ratio, image quality, and spatial resolution. To this end, acquisitions were carried out using a hot cylinder phantom (consisting of five fillable rods with diameters of 5, 4, 3, 2, and 1 mm and a uniform cylindrical chamber) and a custom-made Derenzo phantom, with center-to-center distances between adjacent rods of 1.5, 2.0, and 3.0 mm. Results: Good agreement was found for the spatial response of the system between measured data and results derived from MC-SRM and AE-SRM. Only minor differences for point sources at distances smaller than the radius of rotation and large incidence angles were found. Assessment of the effect on the reconstructed image showed a similar contrast for both approaches, with values higher than 0.9 for rod diameters greater than 1 mm and higher than 0.8 for rod diameter of 1 mm. The comparison in terms of image quality showed that all rods in the different sections of a custom-made Derenzo phantom could be distinguished. The spatial resolution (FWHM) was 0.7 mm at iteration 100 using both approaches. The SNR was lower for reconstructed images using MC-SRM than for those reconstructed using AE-SRM, indicating that AE-SRM deals better with the

  4. Gas turbine rotor/case structural response to rotating stall: Experimental documentation and analytical approach

    NASA Technical Reports Server (NTRS)

    Haley, P. J.

    1982-01-01

    The forcing functions and structural responses characterizing gas turbine rotor/case system vibration due to rotating stall in an axial flow compressor are described. Two data sets with fundamentally different response characteristics are presented; one is supersynchronous and the other subsynchronous. Conventional beam element rotor dynamics analysis is shown to be severely limited in its ability to predict these responses. A new analytical approach, which significantly increases structural response predictive capability for these phenomena, is briefly discussed.

  5. An analytical model for the prediction of a micro-dosimeter response function

    NASA Astrophysics Data System (ADS)

    Badavi, F. F.; Xapsos, M. A.; Wilson, J. W.

    2009-07-01

    A rapid analytical procedure for the prediction of a micro-dosimeter response function in low Earth orbit (LEO), correlated with the Space Transportation System (STS, shuttle) Tissue Equivalent Proportional Counter (TEPC) measurements is presented. The analytical model takes into consideration the energy loss straggling and chord length distribution of the detector, and is capable of predicting energy deposition fluctuations in a cylindrical micro-volume of arbitrary aspect ratio (height/diameter) by incoming ions through both direct and indirect (δ ray) events. At any designated (ray traced) target point within the vehicle, the model accepts the differential flux spectrum of Galactic Cosmic Rays (GCRs) and/or trapped protons at LEO as input. On a desktop PC, the response function of TEPC for each ion in the GCR/trapped field is computed at the average rate of 30 s/ion. The ionizing radiation environment at LEO is represented by O'Neill's GCR model (2004), covering charged particles in the 1 ⩽ Z ⩽ 28 range. O'Neill's free space GCR model is coupled with the Langley Research Center (LaRC) angular dependent geomagnetic cutoff model to compute the transmission coefficient in LEO. The trapped proton environment is represented by a LaRC developed time dependent procedure which couples the AP8MIN/AP8MAX, Deep River Neutron Monitor (DRNM) and F10.7 solar radio frequency measurements. The albedo neutron environment is represented by the extrapolation of the Atmospheric Ionizing Radiation (AIR) measurements. The charged particle transport calculations correlated with STS 51 and 114 flights are accomplished by using the most recent version (2005) of the LaRC deterministic High charge ( Z) and Energy TRaNsport (HZETRN) code. We present the correlations between the TEPC model predictions (response function) and TEPC measured differential/integral spectra in the lineal energy ( y) domain for both GCR and trapped protons, with the conclusion that the model correctly

  6. An analytical model for the prediction of a micro-dosimeter response function

    NASA Astrophysics Data System (ADS)

    Badavi, Francis; Michael, Michael; Wilson, John W.

    A rapid analytical procedure for the prediction of a micro-dosimeter response function in Low Earth Orbit (LEO), correlated with the Space Transportation System (STS, shuttle) Tissue Equivalent Proportional Counter (TEPC) measurements is presented. The analytical model takes into consideration the energy loss straggling and chord length distribution of the detector, and is capable of predicting energy deposition fluctuations in a cylindrical micro-volume of arbitrary aspect ratio (height/diameter) by incoming ions through both direct and indirect (δ rays) events. At any designated (ray traced) target point within the vehicle, the model as input accepts the differential flux spectrum of Galactic Cosmic Rays (GCR) and/or trapped protons at LEO. On a desktop PC, the response function of TEPC for each ion in the GCR/trapped field is computed at the average rate of 30 seconds/ion. The ionizing radiation environment at LEO is represented by O'Neill's GCR model (2004), covering charge particles in the 1≤Z≤28 range. O'Neill's free space GCR model is coupled with the Langley Research Center (LaRC) cutoff model with angular dependency compensation to compute the transmission coefficient at LEO. The trapped proton environment is represented by a LaRC developed time dependent procedure which couples the AP8min/AP8max, Deep River Neutron Monitor (DRNM) and F10.7 solar radio frequency measurements. The albedo neutron environment is represented by the extrapolation of the Atmospheric Ionizing Radiation (AIR) measurements. The charged particle transport calculations correlated with STS 56, 51, 110 and 114 flights are accomplished by using the most recent version (2005) of LaRC's deterministic ionized particle transport code High charge (Z) and Energy TRaNsport (HZETRN). Herein, we present the correlations between the TEPC model predictions (response function) and TEPC measured differential/integral spectra in the lineal energy (y) domain for both GCR and trapped protons, with

  7. An Analytical Model for the Prediction of a Micro-Dosimeter Response Function

    NASA Technical Reports Server (NTRS)

    Badavi, Francis F.; Xapsos, Mike

    2008-01-01

    A rapid analytical procedure for the prediction of a micro-dosimeter response function in low Earth orbit (LEO), correlated with the Space Transportation System (STS, shuttle) Tissue Equivalent Proportional Counter (TEPC) measurements is presented. The analytical model takes into consideration the energy loss straggling and chord length distribution of the detector, and is capable of predicting energy deposition fluctuations in a cylindrical micro-volume of arbitrary aspect ratio (height/diameter) by incoming ions through both direct and indirect (ray) events. At any designated (ray traced) target point within the vehicle, the model accepts the differential flux spectrum of Galactic Cosmic Rays (GCR) and/or trapped protons at LEO as input. On a desktop PC, the response function of TEPC for each ion in the GCR/trapped field is computed at the average rate of 30 seconds/ion. The ionizing radiation environment at LEO is represented by O'Neill fs GCR model (2004), covering charged particles in the 1 less than or equal to Z less than or equal to 28. O'Neill's free space GCR model is coupled with the Langley Research Center (LaRC) angular dependent geomagnetic cutoff model to compute the transmission coefficient in LEO. The trapped proton environment is represented by a LaRC developed time dependent procedure which couples the AP8MIN/AP8MAX, Deep River Neutron Monitor (DRNM) and F10.7 solar radio frequency measurements. The albedo neutron environment is represented by the extrapolation of the Atmospheric Ionizing Radiation (AIR) measurements. The charged particle transport calculations correlated with STS 51 and 114 flights are accomplished by using the most recent version (2005) of the LaRC deterministic High charge (Z) and Energy TRaNsport (HZETRN) code. We present the correlations between the TEPC model predictions (response function) and TEPC measured differential/integral spectra in the lineal energy (y) domain for both GCR and trapped protons, with the conclusion

  8. CD83 Modulates B Cell Activation and Germinal Center Responses.

    PubMed

    Krzyzak, Lena; Seitz, Christine; Urbat, Anne; Hutzler, Stefan; Ostalecki, Christian; Gläsner, Joachim; Hiergeist, Andreas; Gessner, André; Winkler, Thomas H; Steinkasserer, Alexander; Nitschke, Lars

    2016-05-01

    CD83 is a maturation marker for dendritic cells. In the B cell lineage, CD83 is expressed especially on activated B cells and on light zone B cells during the germinal center (GC) reaction. The function of CD83 during GC responses is unclear. CD83(-/-) mice have a strong reduction of CD4(+) T cells, which makes it difficult to analyze a functional role of CD83 on B cells during GC responses. Therefore, in the present study we generated a B cell-specific CD83 conditional knockout (CD83 B-cKO) model. CD83 B-cKO B cells show defective upregulation of MHC class II and CD86 expression and impaired proliferation after different stimuli. Analyses of GC responses after immunization with various Ags revealed a characteristic shift in dark zone and light zone B cell numbers, with an increase of B cells in the dark zone of CD83 B-cKO mice. This effect was not accompanied by alterations in the level of IgG immune responses or by major differences in affinity maturation. However, an enhanced IgE response was observed in CD83 B-cKO mice. Additionally, we observed a strong competitive disadvantage of CD83-cKO B cells in GC responses in mixed bone marrow chimeras. Furthermore, infection of mice with Borrelia burgdorferi revealed a defect in bacterial clearance of CD83 B-cKO mice with a shift toward a Th2 response, indicated by a strong increase in IgE titers. Taken together, our results show that CD83 is important for B cell activation and modulates GC composition and IgE Ab responses in vivo. PMID:26983787

  9. Two Analyte Calibration From The Transient Response Of Potentiometric Sensors Employed With The SIA Technique

    SciTech Connect

    Cartas, Raul; Mimendia, Aitor; Valle, Manel del; Legin, Andrey

    2009-05-23

    Calibration models for multi-analyte electronic tongues have been commonly built using a set of sensors, at least one per analyte under study. Complex signals recorded with these systems are formed by the sensors' responses to the analytes of interest plus interferents, from which a multivariate response model is then developed. This work describes a data treatment method for the simultaneous quantification of two species in solution employing the signal from a single sensor. The approach used here takes advantage of the complex information recorded with one electrode's transient after insertion of sample for building the calibration models for both analytes. The departure information from the electrode was firstly processed by discrete wavelet for transforming the signals to extract useful information and reduce its length, and then by artificial neural networks for fitting a model. Two different potentiometric sensors were used as study case for simultaneously corroborating the effectiveness of the approach.

  10. An academic medical center's response to widespread computer failure.

    PubMed

    Genes, Nicholas; Chary, Michael; Chason, Kevin W

    2013-01-01

    As hospitals incorporate information technology (IT), their operations become increasingly vulnerable to technological breakdowns and attacks. Proper emergency management and business continuity planning require an approach to identify, mitigate, and work through IT downtime. Hospitals can prepare for these disasters by reviewing case studies. This case study details the disruption of computer operations at Mount Sinai Medical Center (MSMC), an urban academic teaching hospital. The events, and MSMC's response, are narrated and the impact on hospital operations is analyzed. MSMC's disaster management strategy prevented computer failure from compromising patient care, although walkouts and time-to-disposition in the emergency department (ED) notably increased. This incident highlights the importance of disaster preparedness and mitigation. It also demonstrates the value of using operational data to evaluate hospital responses to disasters. Quantifying normal hospital functions, just as with a patient's vital signs, may help quantitatively evaluate and improve disaster management and business continuity planning. PMID:24352930

  11. 77 FR 20887 - Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-06

    ... solicits comments on the information needed to measure customer satisfaction with delivered products and... AFFAIRS Proposed Information Collection (National Acquisition Center Customer Response Survey) Activity...: Department of Veterans Affairs (VA) National Acquisition Center Customer Response Survey, VA Form 0863....

  12. 77 FR 38398 - Agency Information Collection (National Acquisition Center Customer Response Survey) Activities...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-27

    ... AFFAIRS Agency Information Collection (National Acquisition Center Customer Response Survey) Activities...) National Acquisition Center Customer Response Survey, VA Form 0863. OMB Control Number: 2900-0676. Type of... customer's feedback and suggestions on delivered products and services administered by the...

  13. Occupational exposures during the World Trade Center disaster response.

    PubMed

    Wallingford, K M; Snyder, E M

    2001-06-01

    Upon the request of the New York City Department of Health, the Centers for Disease Control and Prevention's National Institute for Occupational Safety and Health (NIOSH) monitored occupational exposures among emergency response workers during the rescue and recovery activities at the World Trade Center disaster site from September 18 through 4 October 2001. During this period, over 1,200 bulk and air samples were collected to estimate or characterize workers' occupational exposures. Samples were collected and analyzed for asbestos, carbon monoxide (CO), chlorodifluoromethane (Freon 22), diesel exhaust, hydrogen sulfide, inorganic acids, mercury and other metals, polynuclear aromatic hydrocarbons, respirable particulate not otherwise regulated (PNOR), respirable crystalline silica, total PNOR, and volatile organic compounds. Exposures to most of these potential hazards did not exceed NIOSH Recommended Exposure Limits or Occupational Safety and Health Administration Permissible Exposure Limits. However, one torch cutter was overexposed to cadmium and another worker (and possibly three others) was overexposed to CO. The elevated cadmium and CO levels were the result of workers using oxy-acetylene cutting torches and gasoline-powered cutting saws. Recommendations were made to ensure adequate ventilation and worker understanding when using these tools and, where possible, to substitute rechargeable, battery-powered cutting saws for gasoline-powered ones. Toxicology PMID:12539869

  14. Responsibility-centered management: a 10-year nursing assessment.

    PubMed

    McBride, A B; Neiman, S; Johnson, J

    2000-01-01

    In 1988-89, Indiana University became the first public university to implement responsibility-centered management (RCM) comprehensively. This article describes and assesses the implementation of RCM on the core campus of Indiana University School of Nursing in Indianapolis. It describes how RCM encouraged an information-rich environment, particularly with the advent of economic modeling; decision making linked to strategic goals/objectives; and a performance-based reward structure (e.g., merit pay increases and incentive plans). It ends with a discussion about the worth of RCM and the changes that frame-work produced, particularly in reconceptualizing the roles of the business officer and dean. The most profound consequence of RCM may be the effect it has in encouraging rethinking of what it means to be a school of nursing at this point in time. PMID:10932994

  15. Applied Analytical Combustion/emissions Research at the NASA Lewis Research Center - a Progress Report

    NASA Technical Reports Server (NTRS)

    Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

    1992-01-01

    Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

  16. Applied analytical combustion/emissions research at the NASA Lewis Research Center

    NASA Technical Reports Server (NTRS)

    Deur, J. M.; Kundu, K. P.; Nguyen, H. L.

    1992-01-01

    Emissions of pollutants from future commercial transports are a significant concern. As a result, the Lewis Research Center (LeRC) is investigating various low emission combustor technologies. As part of this effort, a combustor analysis code development program was pursued to guide the combustor design process, to identify concepts having the greatest promise, and to optimize them at the lowest cost in the minimum time.

  17. An Analytical Solution for Transient Thermal Response of an Insulated Structure

    NASA Technical Reports Server (NTRS)

    Blosser, Max L.

    2012-01-01

    An analytical solution was derived for the transient response of an insulated aerospace vehicle structure subjected to a simplified heat pulse. This simplified problem approximates the thermal response of a thermal protection system of an atmospheric entry vehicle. The exact analytical solution is solely a function of two non-dimensional parameters. A simpler function of these two parameters was developed to approximate the maximum structural temperature over a wide range of parameter values. Techniques were developed to choose constant, effective properties to represent the relevant temperature and pressure-dependent properties for the insulator and structure. A technique was also developed to map a time-varying surface temperature history to an equivalent square heat pulse. Using these techniques, the maximum structural temperature rise was calculated using the analytical solutions and shown to typically agree with finite element simulations within 10 to 20 percent over the relevant range of parameters studied.

  18. Pathways to Healing: Person-centered Responses to Complementary Services

    PubMed Central

    Bertrand, Sharon W.; Fermon, Barbara; Coleman, Julie Foley

    2014-01-01

    Objectives: This research study assessed perceived changes in quality-of-life measures related to participation in complementary services consisting of a variety of nontraditional therapies and/or programs at Pathways: A Health Crisis Resource Center in Minneapolis, Minnesota. Design: Survey data were used to assess perceived changes participants ascribed to their experience with complementary services at Pathways. Quantitative data analysis was conducted using participant demographics together with participant ratings of items from the “Self-Assessment of Change” (SAC) measure developed at the University of Arizona, Tucson. Qualitative data analysis was conducted on written responses to an additional survey question: “To what extent has your participation at Pathways influenced your healing process?” Setting/Location: Pathways offers a variety of services, including one-to-one sessions using nontraditional healing therapies, support groups, educational classes, and practice groups such as yoga and meditation for those facing serious health challenges. These services are offered free of charge through community financial support using volunteer practitioners. Participants: People (126) diagnosed with serious health challenges who used Pathways services from 2007 through 2009. Interventions: Participation in self-selected Pathways services. Measures: Responses to items on the SAC measure plus written responses to the question, “To what extent has your participation at Pathways influenced your healing process?” Results: Quantitative findings: Participants reported experiencing significant changes across all components of the SAC measure. Qualitative findings: Responses to the open-ended survey question identified perspectives on the culture of Pathways and a shift in participants' perceptions of well-being based on their experience of Pathways services. Conclusions: Participation in services provided by the Pathways organization improved perceptions of

  19. Empirical evaluation of meta-analytic approaches for nutrient and health outcome dose-response data

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The objective of this study is to empirically compare alternative meta-analytic methods for combining dose-response data from epidemiological studies. We identified meta-analyses of epidemiological studies that analyzed the association between a single nutrient and a dichotomous outcome. For each to...

  20. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 34 Education 3 2010-07-01 2010-07-01 false What are the State's responsibilities to the National Center or Centers for Research in Vocational Education? 403.207 Section 403.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL...

  1. Flight and Analytical Methods for Determining the Coupled Vibration Response of Tandem Helicopters

    NASA Technical Reports Server (NTRS)

    Yeates, John E , Jr; Brooks, George W; Houbolt, John C

    1957-01-01

    Chapter one presents a discussion of flight-test and analysis methods for some selected helicopter vibration studies. The use of a mechanical shaker in flight to determine the structural response is reported. A method for the analytical determination of the natural coupled frequencies and mode shapes of vibrations in the vertical plane of tandem helicopters is presented in Chapter two. The coupled mode shapes and frequencies are then used to calculate the response of the helicopter to applied oscillating forces.

  2. Analytical stability and simulation response study for a coupled two-body system

    NASA Technical Reports Server (NTRS)

    Tao, K. M.; Roberts, J. R.

    1975-01-01

    An analytical stability study and a digital simulation response study of two connected rigid bodies are documented. Relative rotation of the bodies at the connection is allowed, thereby providing a model suitable for studying system stability and response during a soft-dock regime. Provisions are made of a docking port axes alignment torque and a despin torque capability for encountering spinning payloads. Although the stability analysis is based on linearized equations, the digital simulation is based on nonlinear models.

  3. Analytic Solutions for the Spectral Responses of RCA-Grating-Based Waveguide Devices

    NASA Astrophysics Data System (ADS)

    Zeng, Xiang-Kai; Wei, Lai

    2012-12-01

    Analytic solutions (ASs) for the spectral responses of waveguide devices with raised-cosine-apodized (RCA) gratings are presented. The waveguide devices include short- and long-period RCA-gratings, RCA-grating-based interferometers as Fabry—Perot, Mach—Zehnder and Michelson interferometers. The calculations based on the analytic solutions are demonstrated and compared with those based on the transfer matrix (TM) method preferred, which has confirmed that the AS-based analysis is with enough accuracy and several thousands times the efficiency of the TM method.

  4. CRMS vegetation analytical team framework: Methods for collection, development, and use of vegetation response variables

    USGS Publications Warehouse

    Cretini, Kari F.; Visser, Jenneke M.; Krauss, Ken W.; Steyer, Gregory D.

    2011-01-01

    This document identifies the main objectives of the Coastwide Reference Monitoring System (CRMS) vegetation analytical team, which are to provide (1) collection and development methods for vegetation response variables and (2) the ways in which these response variables will be used to evaluate restoration project effectiveness. The vegetation parameters (that is, response variables) collected in CRMS and other coastal restoration projects funded under the Coastal Wetlands Planning, Protection and Restoration Act (CWPPRA) are identified, and the field collection methods for these parameters are summarized. Existing knowledge on community and plant responses to changes in environmental drivers (for example, flooding and salinity) from published literature and from the CRMS and CWPPRA monitoring dataset are used to develop a suite of indices to assess wetland condition in coastal Louisiana. Two indices, the floristic quality index (FQI) and a productivity index, are described for herbaceous and forested vegetation. The FQI for herbaceous vegetation is tested with a long-term dataset from a CWPPRA marsh creation project. Example graphics for this index are provided and discussed. The other indices, an FQI for forest vegetation (that is, trees and shrubs) and productivity indices for herbaceous and forest vegetation, are proposed but not tested. New response variables may be added or current response variables removed as data become available and as our understanding of restoration success indicators develops. Once indices are fully developed, each will be used by the vegetation analytical team to assess and evaluate CRMS/CWPPRA project and program effectiveness. The vegetation analytical teams plan to summarize their results in the form of written reports and/or graphics and present these items to CRMS Federal and State sponsors, restoration project managers, landowners, and other data users for their input.

  5. Analytical Examinations and Compensation Based on Rolling Friction Model for Slow Settling Response in Precise Positioning

    NASA Astrophysics Data System (ADS)

    Maeda, Yoshihiro; Iwasaki, Makoto

    This paper presents a rolling friction model-based friction compensation for precise tracking control of linear motor-driven table systems. Rolling friction in mechanisms behaves as a nonlinear elastic element in the micro-displacement region, and deteriorates the tracking performance with slow settling response in positioning. In this paper, therefore, the rolling friction characteristic is mathematically formulated and is adopted to analytical examinations and compensator design to improve the slow settling response. The proposed compensation has been verified by experiments by using a prototype for industrial positioning devices.

  6. Analytical approach to calculation of response spectra from seismological models of ground motion

    USGS Publications Warehouse

    Safak, Erdal

    1988-01-01

    An analytical approach to calculate response spectra from seismological models of ground motion is presented. Seismological models have three major advantages over empirical models: (1) they help in an understanding of the physics of earthquake mechanisms, (2) they can be used to predict ground motions for future earthquakes and (3) they can be extrapolated to cases where there are no data available. As shown with this study, these models also present a convenient form for the calculation of response spectra, by using the methods of random vibration theory, for a given magnitude and site conditions. The first part of the paper reviews the past models for ground motion description, and introduces the available seismological models. Then, the random vibration equations for the spectral response are presented. The nonstationarity, spectral bandwidth and the correlation of the peaks are considered in the calculation of the peak response.

  7. Academic health center hospitals: alternative responses to financial stress.

    PubMed

    Jones, K R; Sloate, S G

    1987-01-01

    Academic health center hospitals face challenges to their survival in an increasingly competitive, challenging, and entrepreneurial environment. University hospitals face a number of major stresses and are responding in various ways to ensure their financial viability. PMID:3305420

  8. How Porcupines Make Love: Notes on a Response-Centered Curriculum.

    ERIC Educational Resources Information Center

    Purvis, Alan C., Ed.

    These "notes on a response-centered curriculum" specify four objectives of an English program in the schools. In the program an individual is to trust himself; get to know himself; recognize his differences from others; and recognize his similarity with others. After an overview of the response-centered English curriculum, chapters are devoted to:…

  9. Analytical and Numerical Modeling of Pulsed Eddy Current Response to Thin Conducting Plates

    NASA Astrophysics Data System (ADS)

    Tetervak, A.; Krause, T. W.; Mandache, C.; Lefebvre, J. H. V.

    2010-02-01

    Modeling of transient eddy current response in planar structures requires incorporation of all elements within the system comprised of exciting and pick-up coils, and the conducting structure being investigated. The combined response includes the feedback processes that in turn modify the time constants within the system. In this work analytical and numerical methods are utilized to solve for those feedback mechanisms within the circuit-conductor system that generates the final pick-up coil response. Further, applying numerical analysis to results of the modeling, we parameterize probe-sample interaction via lumped-circuit analogies justified for thin samples. Results are compared with experimental measurements where these parameters have been characterized.

  10. Analytical and experimental evaluations of Space Shuttle TPS tile vibration response

    NASA Technical Reports Server (NTRS)

    Piersol, A. G.; Pope, L. D.

    1982-01-01

    Analytical studies and laboratory experiments have been performed to evaluate the vibration response of the Space Shuttle Thermal Protection System (TPS) tiles due to the intense rocket generated acoustic noise during lift-off. The TPS tiles are mounted over the exterior of the Space Shuttle Orbiter structure through Strain Isolation Pads (SIP) which protect the tiles from thermal induced shear loads at their interface. The analytical predictions indicate that the response of a typical tile is governed by the structural vibration inputs through the SIP under the tile at frequencies below 250 Hz, and by the direct acoustic excitation over the exterior surface of the tile at frequencies above 250 Hz. An evaluation of the laboratory test data for this same tile, in which conditioned (partial) coherent output spectral analysis procedures were used, leads to exactly the same conclusion. The results demonstrate the power of conditioned spectral analysis procedures in identifying vibration response mechanisms when two or more of the inputs are highly correlated.

  11. Analytical procedures for estimating structural response to acoustic fields generated by advanced launch systems, phase 2

    NASA Technical Reports Server (NTRS)

    Elishakoff, Isaac; Lin, Y. K.; Zhu, Li-Ping; Fang, Jian-Jie; Cai, G. Q.

    1994-01-01

    This report supplements a previous report of the same title submitted in June, 1992. It summarizes additional analytical techniques which have been developed for predicting the response of linear and nonlinear structures to noise excitations generated by large propulsion power plants. The report is divided into nine chapters. The first two deal with incomplete knowledge of boundary conditions of engineering structures. The incomplete knowledge is characterized by a convex set, and its diagnosis is formulated as a multi-hypothesis discrete decision-making algorithm with attendant criteria of adaptive termination.

  12. Analytic model of energy-absorption response functions in compound X-ray detector materials.

    PubMed

    Yun, Seungman; Kim, Ho Kyung; Youn, Hanbean; Tanguay, Jesse; Cunningham, Ian A

    2013-10-01

    The absorbed energy distribution (AED) in X-ray imaging detectors is an important factor that affects both energy resolution and image quality through the Swank factor and detective quantum efficiency. In the diagnostic energy range (20-140 keV), escape of characteristic photons following photoelectric absorption and Compton scatter photons are primary sources of absorbed-energy dispersion in X-ray detectors. In this paper, we describe the development of an analytic model of the AED in compound X-ray detector materials, based on the cascaded-systems approach, that includes the effects of escape and reabsorption of characteristic and Compton-scatter photons. We derive analytic expressions for both semi-infinite slab and pixel geometries and validate our approach by Monte Carlo simulations. The analytic model provides the energy-dependent X-ray response function of arbitrary compound materials without time-consuming Monte Carlo simulations. We believe this model will be useful for correcting spectral distortion artifacts commonly observed in photon-counting applications and optimal design and development of novel X-ray detectors. PMID:23744671

  13. Aquifer response to stream-stage and recharge variations. I. Analytical step-response functions

    USGS Publications Warehouse

    Moench, A.F.; Barlow, P.M.

    2000-01-01

    Laplace transform step-response functions are presented for various homogeneous confined and leaky aquifer types and for anisotropic, homogeneous unconfined aquifers interacting with perennial streams. Flow is one-dimensional, perpendicular to the stream in the confined and leaky aquifers, and two-dimensional in a plane perpendicular to the stream in the water-table aquifers. The stream is assumed to penetrate the full thickness of the aquifer. The aquifers may be semi-infinite or finite in width and may or may not be bounded at the stream by a semipervious streambank. The solutions are presented in a unified manner so that mathematical relations among the various aquifer configurations are clearly demonstrated. The Laplace transform solutions are inverted numerically to obtain the real-time step-response functions for use in the convolution (or superposition) integral. To maintain linearity in the case of unconfined aquifers, fluctuations in the elevation of the water table are assumed to be small relative to the saturated thickness, and vertical flow into or out of the zone above the water table is assumed to occur instantaneously. Effects of hysteresis in the moisture distribution above the water table are therefore neglected. Graphical comparisons of the new solutions are made with known closed-form solutions.Laplace transform step-response functions are presented for various homogeneous confined and leaky aquifer types and for anisotropic, homogeneous unconfined aquifers interacting with perennial streams. Flow is one-dimensional, perpendicular to the stream in the confined and leaky aquifers, and two-dimensional in a plane perpendicular to the stream in the water-table aquifers. The stream is assumed to penetrate the full thickness of the aquifer. The aquifers may be semi-infinite or finite in width and may or may not be bounded at the stream by a semipervious streambank. The solutions are presented in a unified manner so that mathematical relations among the

  14. On the use of a uniformly valid analytical cascade response function for fan broadband noise predictions

    NASA Astrophysics Data System (ADS)

    Posson, H.; Moreau, S.; Roger, M.

    2010-08-01

    The present paper extends an existing analytical model of the aeroacoustic response of a rectilinear cascade of flat-plate blades to three-dimensional incident vortical gusts, to the prediction of the noise generated by a three-dimensional annular blade-row. The extended formulation is meant to be implemented in a fan broadband noise prediction tool. The intended applications include the modern turbofan engines, for which analytical modelling is believed to be a good alternative to more expensive numerical techniques. The prediction noise model resorts to a strip theory approach based on a three-dimensional rectilinear cascade model. The latter is based on the Wiener-Hopf technique, and yields the pressure field in the blade passage and the unsteady blade loading. The analytical pressure solution is derived by making an extensive use of the residue theorem. The obtained unsteady blade loading distribution over the blades is then used as a dipole source distribution in an acoustic analogy applied in the annular rigid duct with uniform mean flow. The new achievements are then tested on three-dimensional annular-benchmark configurations and compared with three-dimensional lifting-surface models and three-dimensional Euler linearized codes available in the literature. The accuracy of the model is shown for high hub-to-tip ratio cases. When used as such in a true rectilinear-cascade configuration, it also reproduces the exact radiated field that can be derived directly. For low hub-to-tip ratio configurations, the model departs from three-dimensional computations, both regarding the blade loading and the acoustic radiation. A correction is proposed to account for the actual annular dispersion relation in the rectilinear-cascade response function. The results suggest that the proposed correction is necessary to get closer to the underlying physics of the annular-space wave equation, but that it is yet not sufficient to fully reproduce three-dimensional results.

  15. Big Data Analytics for Disaster Preparedness and Response of Mobile Communication Infrastructure during Natural Hazards

    NASA Astrophysics Data System (ADS)

    Zhong, L.; Takano, K.; Ji, Y.; Yamada, S.

    2015-12-01

    The disruption of telecommunications is one of the most critical disasters during natural hazards. As the rapid expanding of mobile communications, the mobile communication infrastructure plays a very fundamental role in the disaster response and recovery activities. For this reason, its disruption will lead to loss of life and property, due to information delays and errors. Therefore, disaster preparedness and response of mobile communication infrastructure itself is quite important. In many cases of experienced disasters, the disruption of mobile communication networks is usually caused by the network congestion and afterward long-term power outage. In order to reduce this disruption, the knowledge of communication demands during disasters is necessary. And big data analytics will provide a very promising way to predict the communication demands by analyzing the big amount of operational data of mobile users in a large-scale mobile network. Under the US-Japan collaborative project on 'Big Data and Disaster Research (BDD)' supported by the Japan Science and Technology Agency (JST) and National Science Foundation (NSF), we are going to investigate the application of big data techniques in the disaster preparedness and response of mobile communication infrastructure. Specifically, in this research, we have considered to exploit the big amount of operational information of mobile users for predicting the communications needs in different time and locations. By incorporating with other data such as shake distribution of an estimated major earthquake and the power outage map, we are able to provide the prediction information of stranded people who are difficult to confirm safety or ask for help due to network disruption. In addition, this result could further facilitate the network operators to assess the vulnerability of their infrastructure and make suitable decision for the disaster preparedness and response. In this presentation, we are going to introduce the

  16. A regional burn center's response to a disaster: September 11, 2001, and the days beyond.

    PubMed

    Yurt, Roger W; Bessey, Palmer Q; Bauer, Gregory J; Dembicki, Robert; Laznick, Hope; Alden, Nicole; Rabbits, Angela

    2005-01-01

    This report reviews the response of a regional burn center to the disaster that occurred in New York City at the World Trade Center on September 11, 2001. In addition, it assesses that response in the context of other medical institutions in the region. There were facilities in the region that had 120 burn care beds; only two-thirds of the burn-injured patients who required hospital admission were admitted to designated burn centers, and only 28% of burn-injured victims initially were triaged to regional burn centers. The care rendered at this center was made possible by a "disaster-ready" facility and supplementation of personnel from the resources provided by The National Disaster Medical System. The patient outcomes at this center exceeded that as predicted by logistic regression analysis. PMID:15756112

  17. Implementing Response to Intervention in Context. A Center Practice Brief

    ERIC Educational Resources Information Center

    Center for Mental Health in Schools at UCLA, 2011

    2011-01-01

    Response to intervention is meant to be broad-based and preventative. However, as formulated and practiced the approach often is too limited in how it frames what needs to go on to enable learning, engage students, and keep them engaged. In particular, it pays too little attention to the need to strengthen the classroom and schoolwide context in…

  18. Radioanalytical Data Quality Objectives and Measurement Quality Objectives during a Federal Radiological Monitoring and Assessment Center Response

    SciTech Connect

    E. C. Nielsen

    2006-01-01

    During the early and intermediate phases of a nuclear or radiological incident, the Federal Radiological Monitoring and Assessment Center (FRMAC) collects environmental samples that are analyzed by organizations with radioanalytical capability. Resources dedicated to quality assurance (QA) activities must be sufficient to assure that appropriate radioanalytical measurement quality objectives (MQOs) and assessment data quality objectives (DQOs) are met. As the emergency stabilizes, QA activities will evolve commensurate with the need to reach appropriate DQOs. The MQOs represent a compromise between precise analytical determinations and the timeliness necessary for emergency response activities. Minimum detectable concentration (MDC), lower limit of detection, and critical level tests can all serve as measurements reflecting the MQOs. The relationship among protective action guides (PAGs), derived response levels (DRLs), and laboratory detection limits is described. The rationale used to determine the appropriate laboratory detection limit is described.

  19. Responsibility Center Management: A Financial Paradigm and Alternative to Decentralized Budgeting.

    ERIC Educational Resources Information Center

    Hensley, Phyllis A.; Bava, D. J.; Brennan, Denise C.

    This study examined the implementation of Responsibility Center Management (RCM) systems in two institutions of higher education: the Graduate School of Business at Institution and the Center of Collaborative Education and Professional Studies at Institution B. RCM is a management and budgeting process for universities that decentralizes authority…

  20. Electrogenerated thin films of microporous polymer networks with remarkably increased electrochemical response to nitroaromatic analytes.

    PubMed

    Palma-Cando, Alex; Scherf, Ullrich

    2015-06-01

    Thin films of microporous polymer networks (MPNs) have been generated by electrochemical polymerization of a series of multifunctional carbazole-based monomers. The microporous films show high Brunauer-Emmett-Teller (BET) surface areas up to 1300 m2 g(-1) as directly measured by krypton sorption experiments. A correlation between the number of polymerizable carbazole units of the monomer and the resulting surface area is observed. Electrochemical sensing experiments with 1,3,5-trinitrobenzene as prototypical nitroaromatic analyte demonstrate an up to 180 times increased current response of MPN-modified glassy carbon electrodes in relation to the nonmodified electrode. The phenomenon probably involves intermolecular interactions between the electron-poor nitroaromatic analytes and the electron-rich, high surface area microporous deposits, with the electrochemical reduction at the MPN-modified electrodes being an adsorption-controlled process for low scan rates. We expect a high application potential of such MPN-modified electrodes for boosting the sensitivity of electrochemical sensor devices. PMID:25946727

  1. Analytical Sensor Response Function of Viscosity Sensors Based on Layered Piezoelectric Thickness Shear Resonators

    NASA Astrophysics Data System (ADS)

    Benes, Ewald; Nowotny, Helmut; Braun, Stefan; Radel, Stefan; Gröschl, Martin

    Resonant piezoelectric sensors based on bulk acoustic wave (BAW) thickness shear resonators are promising for the inline measurement of fluid viscosity, e.g., in industrial processes. The sensor response function can be derived from the general rigorous transfer matrix description of one-dimensional layered structures consisting of piezoelectric and non-piezoelectric layers of arbitrary number. This model according to Nowotny et al. provides a complete analytical description of the electrical and mechanical behaviour of such structures with two electrodes and arbitrary acoustic termination impedances (Rig-1d-Model). We apply this model to derive the sensor response functions and the mechanical displacement curves of the following configurations appropriate for viscosity sensors: An AT cut quartz crystal plate in contact with vacuum at the backside plane and with the liquid under investigation at the front side plane (QL). An AT cut quartz crystal in contact with the liquid under investigation at both sides (LQL). It is shown that in the QL case the originally only heuristically introduced and well established sensor response function according to Kanasawa can be derived from the Rig-1d-Model by introducing minor approximations. Experimental results are presented for the LQL configuration using an N1000 viscosity reference oil as test fluid.

  2. Evaluation of a wind-tunnel gust response technique including correlations with analytical and flight test results

    NASA Technical Reports Server (NTRS)

    Redd, L. T.; Hanson, P. W.; Wynne, E. C.

    1979-01-01

    A wind tunnel technique for obtaining gust frequency response functions for use in predicting the response of flexible aircraft to atmospheric turbulence is evaluated. The tunnel test results for a dynamically scaled cable supported aeroelastic model are compared with analytical and flight data. The wind tunnel technique, which employs oscillating vanes in the tunnel throat section to generate a sinusoidally varying flow field around the model, was evaluated by use of a 1/30 scale model of the B-52E airplane. Correlation between the wind tunnel results, flight test results, and analytical predictions for response in the short period and wing first elastic modes of motion are presented.

  3. An experimental and analytical investigation on the response of GR/EP composite I-frames

    NASA Astrophysics Data System (ADS)

    Moas, E., Jr.; Boitnott, R. L.; Griffin, O. H., Jr.

    1991-05-01

    Six-foot diameter, semicircular graphite/epoxy specimens representative of generic aircraft frames were loaded quasi-statically to determine their load response and failure mechanisms for large deflections that occur in an airplane crash. These frame-skin specimens consisted of a cylindrical skin section cocured with a semicircular I-frame. Various frame laminate stacking sequences and geometries were evaluated by statically loading the specimen until multiple failures occurred. Two analytical methods were compared for modeling the frame-skin specimens: a two-dimensional branched-shell finite element analysis and a one-dimensional, closed-form, curved beam solution derived using an energy method. Excellent correlation was obtained between experimental results and the finite element predictions of the linear response of the frames prior to the initial failure. The beam solution was used for rapid parameter and design studies, and was found to be stiff in comparison with the finite element analysis. The specimens were found to be useful for evaluating composite frame designs.

  4. Analytical solutions for the seismic response of underground structures under SH wave propagation

    SciTech Connect

    Smerzini, C.; Aviles, J.; Sanchez-Sesma, F. J.

    2008-07-08

    A theoretical approach is presented to study the antiplane seismic response of underground structures subjected to the incidence of plane waves. The structure is assumed to be a circular inclusion embedded in a homogenous, isotropic and linear visco-elastic halfspace and its mathematical formulation is approached through the theory of multiple scattering and diffraction. The inclusion may consist either of a cavity, with or without a ring-shaped boundary, or it may be filled in with a linear-elastic material, without loss of generality. The seismic response of the inclusion and its influence on surface ground motions are analyzed in both frequency and time domains. The dependence of the transfer function amplitudes on several parameters, such as the angle of incident SH waves, the frequency content of the excitation, the impedance contrast between the inclusion and the surrounding medium and the position along the ground surface, is underlined. Considering the lack of analytical solutions for quantifying the modification of ground motions induced by subterranean inhomogeneities, the results of this study can be used, on one side, as benchmark for both geophysical investigations and numerical dynamic soil-structure interaction studies, and, on the other side, to support the formulation of simplified approaches and/or formulas for the seismic design and assessment of underground structures.

  5. Analytical simulation of nonlinear response to seismic test excitations of HDR-VKL piping system

    SciTech Connect

    Srinivasan, M.G.; Kot, C.A. ); Mojtahed, M. )

    1991-01-01

    Dynamic tests with simulated earthquake excitation (SHAM) were performed during April--May 1988 on the Versuchskreislauf (VKL) piping system at the Heissdampfreaktor (HDR) Test Facility in Kahl/Main, Federal Republic of Germany. The major objectives of these tests were to study the behavior of a full-scale in-plant piping system subjected to a range of seismic excitation levels (from design levels to those that might induce either failure of pipe supports or plasticity in the pipe runs) and to establish seismic margins for piping and pipe supports. Data obtained in the tests are also being used to validate analytical methods for piping response calculation. Detailed reports on the SHAM experiments are given elsewhere by Kot et al. (1990). This paper describes an effort to evaluate the computer code NONPIPE (proprietary to Nutech Engineers) with data from one of the SHAM tests. NONPIPE is a nonlinear finite-element program capable of calculating the elastic-plastic response of piping systems subjected to seismic excitation. The special characteristic of this code is the simplified or approximate approach it uses for modeling the elastic behavior which makes the calculations relatively less resource intensive than those of other nonlinear codes. The evaluation is based on a comparison of computational results of simulation of a SHAM test with corresponding test measurements. 6 refs., 10 figs.

  6. How Porcupines Make Love II: Teaching a Response-Centered Literature Curriculum.

    ERIC Educational Resources Information Center

    Purves, Alan C.; And Others

    Written in the same spirit as the earlier edition but thoroughly revised and updated, this book is designed to make teachers aware of reader-response theory and its implications for literature instruction and curriculum. The book demonstrates how a response-centered curriculum brings students to a greater understanding of all forms of literature…

  7. Analysing task design and students' responses to context-based problems through different analytical frameworks

    NASA Astrophysics Data System (ADS)

    Broman, Karolina; Bernholt, Sascha; Parchmann, Ilka

    2015-05-01

    found successful to analyse both the test items as well as students' responses in a systematic way. The framework can therefore be applied in the design of new tasks, the analysis and assessment of students' responses, and as a tool for teachers to scaffold students in their problem-solving process. Conclusions:This paper gives implications for practice and for future research to both develop new context-based problems in a structured way, as well as providing analytical tools for investigating students' higher order thinking in their responses to these tasks.

  8. Analytic calculation of second-order electric response properties with the normalized elimination of the small component (NESC) method

    NASA Astrophysics Data System (ADS)

    Zou, Wenli; Filatov, Michael; Cremer, Dieter

    2012-08-01

    Analytic second derivatives of the relativistic energy for the calculation of electric response properties are derived utilizing the normalized elimination of the small component (NESC) method. Explicit formulas are given for electric static dipole polarizabilities and infrared intensities by starting at the NESC representation of electric dipole moments. The analytic derivatives are implemented in an existing NESC program and applied to calculate dipole moments, polarizabilities, and the infrared spectra of gold- and mercury-containing molecules as well as some actinide molecules. Comparison with experiment reveals the accuracy of NESC second order electric response properties.

  9. Visual analytics of phosphorylation time-series data on insulin response

    NASA Astrophysics Data System (ADS)

    Ma, David K. G.; Stolte, Christian; Kaur, Sandeep; Bain, Michael; O'Donoghue, Seán I.

    2013-10-01

    Visual analysis of time-series data on protein phosphorylation presents a particular challenge: bioinformatics tools currently available for visualising 'omics' data in time series have been developed primarily to study gene expression, and cannot easily be adopted to phosphorylation data, where a single protein typically has multiple phosphosites. In this study, we worked with an experimental research group that is applying very recent methods in high-throughput experimental proteomics to study the time course of protein phosphorylation events in human cells in vitro following stimulation by insulin, as part of a broader study of diabetes and obesity. We applied several existing visual analytics approaches with the goal of organising the data to facilitate new insight into underlying molecular processes. We developed a novel layout strategy called 'Minardo' that is loosely based on cell topology and ordered by time and causality. This layout utilises a frame of reference familiar to life scientists and helpful for organising and interpreting time-series data. This strategy proved to be useful, leading to new insights into the insulin response pathway. We are working on generalising the Minardo layout to accommodate similar datasets related to other signalling pathways, which should be straightforward.

  10. Conceptual design report, Hazardous Materials Management and Emergency Response (HAMMER) Training Center

    SciTech Connect

    Kelly, K.E.

    1994-11-09

    For the next 30 years, the main activities at the US Department of Energy (DOE) Hanford Site will involve the management, handling, and cleanup of toxic substances. If the DOE is to meet its high standards of safety, the thousands of workers involved in these activities will need systematic training appropriate to their tasks and the risks associated with these tasks. Furthermore, emergency response for DOE shipments is the primary responsibility of state, tribal, and local governments. A collaborative training initiative with the DOE will strengthen emergency response at the Hanford Site and within the regional communities. Local and international labor has joined the Hazardous Materials Management and Emergency Response (HAMMER) partnership, and will share in the HAMMER Training Center core programs and facilities using their own specialized trainers and training programs. The HAMMER Training Center will provide a centralized regional site dedicated to the training of hazardous material, emergency response, and fire fighting personnel.

  11. Response of a stainless steel cylinder with elliptical ends subjected to an off-center blast load

    SciTech Connect

    Martineau, R.; Romero, C.

    1996-06-01

    The response of a stainless steel cylindrical vessel with asymmetric internal blast loading is investigated by experiments, computations, and analysis. Previous research has focused on the response of cylindrical vessels for a centrally located charge. The vessel`s geometry consists of a thin shell cylinder with 2:1 elliptical ends. The high explosive charge is located on the vessel`s axis of symmetry and is axially offset from its geometric center. All explosives are spherical in shape and centrally initiated inside the vessel. The vessel holds the high explosive in air at ambient temperature and pressure. Two-dimensional, Eulerian finite difference calculations from a hydrodynamic code (MESA-2D) are used to study the blast phenomenon and pressure loading on the vessel walls. The loading pulse is compared to data obtained from four experiments where several pressure transducers are positioned along the vessel`s circumference. The calculated two-dimensional loading is applied to a three-dimensional explicit finite element model (DYNA-3D) to predict the structural response of the vessel. The vessel`s structural response from the experimental wave interaction is recorded using strain gages, positioned along its circumference, and then compared with the finite element calculations. These results (experimental and computational) are then compared with analytical predictions and prove to correlate well at distances away from the ends. Experimental and computational results compare well at all other locations.

  12. A Response to "Measuring Students' Writing Ability on a Computer Analytic Developmental Scale: An Exploratory Validity Study"

    ERIC Educational Resources Information Center

    Reutzel, D. Ray; Mohr, Kathleen A. J.

    2014-01-01

    In this response to "Measuring Students' Writing Ability on a Computer Analytic Developmental Scale: An Exploratory Validity Study," the authors agree that assessments should seek parsimony in both theory and application wherever possible. Doing so allows maximal dissemination and implementation while minimizing costs. The Writing…

  13. Analytical treatment of two-center overlap integral with respect to same screening constants over Slater type orbitals

    NASA Astrophysics Data System (ADS)

    Ćopuroǧlu, Ebru; Mamedov, Bahtiyar A.

    2016-08-01

    By the use of Löwdin- α radial function, an alternative method is introduced for two-center overlap integral over Slater type orbitals (STOs) at same screening constants (SSC). Notice that the overlap integrals with SSC have an important role in accurate evaluation of multicenter multielectron molecular integrals arising in combined Hartree-Fock-Roothaan (CHFR) theory. This approximation provides us simple and efficient expression for the two-center overlap integrals. To show the effectiveness of established formula we have compared our results with available literature data. The method ensures high performance with a very short CPU time.

  14. Edge analyzing properties of center/surround response functions in cybernetic vision

    NASA Technical Reports Server (NTRS)

    Jobson, D. J.

    1984-01-01

    The ability of center/surround response functions to make explicit high resolution spatial information in optical images was investigated by performing convolutions of two dimensional response functions and image intensity functions (mainly edges). The center/surround function was found to have the unique property of separating edge contrast from shape variations and of providing a direct basis for determining contrast and subsequently shape of edges in images. Computationally simple measures of contrast and shape were constructed for potential use in cybernetic vision systems. For one class of response functions these measures were found to be reasonably resilient for a range of scan direction and displacements of the response functions relative to shaped edges. A pathological range of scan directions was also defined and methods for detecting and handling these cases were developed. The relationship of these results to biological vision is discussed speculatively.

  15. Treatment Verification: Multiple Analytical Methods and a Search for Causality in the Child Parent Center Compensatory Education Program.

    ERIC Educational Resources Information Center

    Conrad, Kendon J.; And Others

    Treatment verification methodology was employed in studying the Chicago Child Parent Center (CPC) compensatory education program. Established in disadvantaged areas by the Chicago public schools, CPCs are designed to break the cycle of poverty through educational intervention with children at ages 3 through 8. An element of evaluation studies that…

  16. NASA Headquarters Space Operations Center: Providing Situational Awareness for Spaceflight Contingency Response

    NASA Technical Reports Server (NTRS)

    Maxwell, Theresa G.; Bihner, William J.

    2010-01-01

    This paper discusses the NASA Headquarters mishap response process for the Space Shuttle and International Space Station programs, and how the process has evolved based on lessons learned from the Space Shuttle Challenger and Columbia accidents. It also describes the NASA Headquarters Space Operations Center (SOC) and its special role in facilitating senior management's overall situational awareness of critical spaceflight operations, before, during, and after a mishap, to ensure a timely and effective contingency response.

  17. Sinusoidal Siemens star spatial frequency response measurement errors due to misidentified target centers

    SciTech Connect

    Birch, Gabriel Carisle; Griffin, John Clark

    2015-07-23

    Numerous methods are available to measure the spatial frequency response (SFR) of an optical system. A recent change to the ISO 12233 photography resolution standard includes a sinusoidal Siemens star test target. We take the sinusoidal Siemens star proposed by the ISO 12233 standard, measure system SFR, and perform an analysis of errors induced by incorrectly identifying the center of a test target. We show a closed-form solution for the radial profile intensity measurement given an incorrectly determined center and describe how this error reduces the measured SFR of the system. As a result, using the closed-form solution, we propose a two-step process by which test target centers are corrected and the measured SFR is restored to the nominal, correctly centered values.

  18. Sinusoidal Siemens star spatial frequency response measurement errors due to misidentified target centers

    DOE PAGESBeta

    Birch, Gabriel Carisle; Griffin, John Clark

    2015-07-23

    Numerous methods are available to measure the spatial frequency response (SFR) of an optical system. A recent change to the ISO 12233 photography resolution standard includes a sinusoidal Siemens star test target. We take the sinusoidal Siemens star proposed by the ISO 12233 standard, measure system SFR, and perform an analysis of errors induced by incorrectly identifying the center of a test target. We show a closed-form solution for the radial profile intensity measurement given an incorrectly determined center and describe how this error reduces the measured SFR of the system. As a result, using the closed-form solution, we proposemore » a two-step process by which test target centers are corrected and the measured SFR is restored to the nominal, correctly centered values.« less

  19. Teaching Language Arts: A Student- and Response-Centered Classroom. Third Edition.

    ERIC Educational Resources Information Center

    Cox, Carole

    Continuing its emphasis on a student- and response-centered approach to literature-based teaching in today's culturally and linguistically diverse classrooms, this third edition discusses these principles not only through explanation, but through examples of real teachers in real classrooms involved in the actual implementation of these ideas. The…

  20. Measurement of Plastic Stress and Strain for Analytical Method Verification (MSFC Center Director's Discretionary Fund Project No. 93-08)

    NASA Technical Reports Server (NTRS)

    Price, J. M.; Steeve, B. E.; Swanson, G. R.

    1999-01-01

    The analytical prediction of stress, strain, and fatigue life at locations experiencing local plasticity is full of uncertainties. Much of this uncertainty arises from the material models and their use in the numerical techniques used to solve plasticity problems. Experimental measurements of actual plastic strains would allow the validity of these models and solutions to be tested. This memorandum describes how experimental plastic residual strain measurements were used to verify the results of a thermally induced plastic fatigue failure analysis of a space shuttle main engine fuel pump component.

  1. A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy

    PubMed Central

    2015-01-01

    Hydrogen sulfide (H2S) is a critical gaseous signaling molecule emerging at the center of a rich field of chemical and biological research. As our understanding of the complexity of physiological H2S in signaling pathways evolves, advanced chemical and technological investigative tools are required to make sense of this interconnectivity. Toward this goal, we have developed an azide-functionalized O-methylrhodol fluorophore, MeRho-Az, which exhibits a rapid >1000-fold fluorescence response when treated with H2S, is selective for H2S over other biological analytes, and has a detection limit of 86 nM. Additionally, the MeRho-Az scaffold is less susceptible to photoactivation than other commonly used azide-based systems, increasing its potential application in imaging experiments. To demonstrate the efficacy of this probe for H2S detection, we demonstrate the ability of MeRho-Az to detect differences in H2S levels in C6 cells and those treated with AOAA, a common inhibitor of enzymatic H2S synthesis. Expanding the use of MeRho-Az to complex and heterogeneous biological settings, we used MeRho-Az in combination with light sheet fluorescence microscopy (LSFM) to visualize H2S in the intestinal tract of live zebrafish. This application provides the first demonstration of analyte-responsive 3D imaging with LSFM, highlighting the utility of combining new probes and live imaging methods for investigating chemical signaling in complex multicellular systems. PMID:26061541

  2. A Bright Fluorescent Probe for H2S Enables Analyte-Responsive, 3D Imaging in Live Zebrafish Using Light Sheet Fluorescence Microscopy.

    PubMed

    Hammers, Matthew D; Taormina, Michael J; Cerda, Matthew M; Montoya, Leticia A; Seidenkranz, Daniel T; Parthasarathy, Raghuveer; Pluth, Michael D

    2015-08-19

    Hydrogen sulfide (H2S) is a critical gaseous signaling molecule emerging at the center of a rich field of chemical and biological research. As our understanding of the complexity of physiological H2S in signaling pathways evolves, advanced chemical and technological investigative tools are required to make sense of this interconnectivity. Toward this goal, we have developed an azide-functionalized O-methylrhodol fluorophore, MeRho-Az, which exhibits a rapid >1000-fold fluorescence response when treated with H2S, is selective for H2S over other biological analytes, and has a detection limit of 86 nM. Additionally, the MeRho-Az scaffold is less susceptible to photoactivation than other commonly used azide-based systems, increasing its potential application in imaging experiments. To demonstrate the efficacy of this probe for H2S detection, we demonstrate the ability of MeRho-Az to detect differences in H2S levels in C6 cells and those treated with AOAA, a common inhibitor of enzymatic H2S synthesis. Expanding the use of MeRho-Az to complex and heterogeneous biological settings, we used MeRho-Az in combination with light sheet fluorescence microscopy (LSFM) to visualize H2S in the intestinal tract of live zebrafish. This application provides the first demonstration of analyte-responsive 3D imaging with LSFM, highlighting the utility of combining new probes and live imaging methods for investigating chemical signaling in complex multicellular systems. PMID:26061541

  3. Antibody Responses After Analytic Treatment Interruption in Human Immunodeficiency Virus-1-Infected Individuals on Early Initiated Antiretroviral Therapy

    PubMed Central

    Stephenson, Kathryn E.; Neubauer, George H.; Bricault, Christine A.; Shields, Jennifer; Bayne, Madeleine; Reimer, Ulf; Pawlowski, Nikolaus; Knaute, Tobias; Zerweck, Johannes; Seaman, Michael S.; Rosenberg, Eric S.; Barouch, Dan H.

    2016-01-01

    The examination of antibody responses in human immunodeficiency virus (HIV)-1-infected individuals in the setting of antiretroviral treatment (ART) interruption can provide insight into the evolution of antibody responses during viral rebound. In this study, we assessed antibody responses in 20 subjects in AIDS Clinical Trials Group A5187, wherein subjects were treated with antiretroviral therapy during acute/early HIV-1 infection, underwent analytic treatment interruption, and subsequently demonstrated viral rebound. Our data suggest that early initiation of ART arrests the maturation of HIV-1-specific antibody responses, preventing epitope diversification of antibody binding and the development of functional neutralizing capacity. Antibody responses do not appear permanently blunted, however, because viral rebound triggered the resumption of antibody maturation in our study. We also found that antibody responses measured by these assays did not predict imminent viral rebound. These data have important implications for the HIV-1 vaccine and eradication fields. PMID:27419172

  4. Chemometric study of the influence of instrumental parameters on ESI-MS analyte response using full factorial design

    NASA Astrophysics Data System (ADS)

    Raji, M. A.; Schug, K. A.

    2009-01-01

    Full factorial experimental design technique was used to study the main effects and the interaction effects between instrumental parameters in two mass spectrometers equipped with conventional electrospray ion sources (Thermo LCQ Deca XP and Shimadzu LCMS 2010). Four major parameters (spray voltage, ion transfer capillary temperature, ion transfer capillary voltage, and tube lens voltage) were investigated in both instruments for their contribution to analyte response, leading to a total of 16 experiments performed for each instrument. Significant parameters were identified by plotting the cumulative probability of each treatment against the estimated effects in normal plots. Analysis of variance (ANOVA) was employed to evaluate the statistical significance of the effects of the parameters on ESI-MS analyte response. The results reveal a number of important interactions in addition to the main effects for each instrument. In all the experiments performed, the tube lens voltage (or Q-array dc voltage in LCMS 2010) was found to have significant effects on analyte response in both instruments. The tube lens voltage was also found to interact with the capillary temperature in the case of the LCQ Deca XP and with the spray voltage in the case of the LCMS 2010. The results of these experiments provide important considerations in the instrumental optimization of ionization response for ESI-MS analysis.

  5. Characterizing the Relationship between Steady State and Response Using Analytical Expressions for the Steady States of Mass Action Models

    PubMed Central

    Loriaux, Paul Michael; Tesler, Glenn; Hoffmann, Alexander

    2013-01-01

    The steady states of cells affect their response to perturbation. Indeed, diagnostic markers for predicting the response to therapeutic perturbation are often based on steady state measurements. In spite of this, no method exists to systematically characterize the relationship between steady state and response. Mathematical models are established tools for studying cellular responses, but characterizing their relationship to the steady state requires that it have a parametric, or analytical, expression. For some models, this expression can be derived by the King-Altman method. However, King-Altman requires that no substrate act as an enzyme, and is therefore not applicable to most models of signal transduction. For this reason we developed py-substitution, a simple but general method for deriving analytical expressions for the steady states of mass action models. Where the King-Altman method is applicable, we show that py-substitution yields an equivalent expression, and at comparable efficiency. We use py-substitution to study the relationship between steady state and sensitivity to the anti-cancer drug candidate, dulanermin (recombinant human TRAIL). First, we use py-substitution to derive an analytical expression for the steady state of a published model of TRAIL-induced apoptosis. Next, we show that the amount of TRAIL required for cell death is sensitive to the steady state concentrations of procaspase 8 and its negative regulator, Bar, but not the other procaspase molecules. This suggests that activation of caspase 8 is a critical point in the death decision process. Finally, we show that changes in the threshold at which TRAIL results in cell death is not always equivalent to changes in the time of death, as is commonly assumed. Our work demonstrates that an analytical expression is a powerful tool for identifying steady state determinants of the cellular response to perturbation. All code is available at http://signalingsystems.ucsd.edu/models-and-code/ or

  6. Preparedness and Emergency Response Research Centers: Using a Public Health Systems Approach to Improve All-Hazards Preparedness and Response

    PubMed Central

    Leinhos, Mary; Williams-Johnson, Mildred

    2014-01-01

    In 2008, at the request of the Centers for Disease Control and Prevention (CDC), the Institute of Medicine (IOM) prepared a report identifying knowledge gaps in public health systems preparedness and emergency response and recommending near-term priority research areas. In accordance with the Pandemic and All-Hazards Preparedness Act mandating new public health systems research for preparedness and emergency response, CDC provided competitive awards establishing nine Preparedness and Emergency Response Research Centers (PERRCs) in accredited U.S. schools of public health. The PERRCs conducted research in four IOM-recommended priority areas: (1) enhancing the usefulness of public health preparedness and response (PHPR) training, (2) creating and maintaining sustainable preparedness and response systems, (3) improving PHPR communications, and (4) identifying evaluation criteria and metrics to improve PHPR for all hazards. The PERRCs worked closely with state and local public health, community partners, and advisory committees to produce practice-relevant research findings. PERRC research has generated more than 130 peer-reviewed publications and nearly 80 practice and policy tools and recommendations with the potential to significantly enhance our nation's PHPR to all hazards and that highlight the need for further improvements in public health systems. PMID:25355970

  7. The National United States Center Data Repository: Core essential interprofessional practice & education data enabling triple aim analytics.

    PubMed

    Pechacek, Judith; Shanedling, Janet; Lutfiyya, May Nawal; Brandt, Barbara F; Cerra, Frank B; Delaney, Connie White

    2015-01-01

    Understanding the impact that interprofessional education and collaborative practice (IPECP) might have on triple aim patient outcomes is of high interest to health care providers, educators, administrators, and policy makers. Before the work undertaken by the National Center for Interprofessional Practice and Education at the University of Minnesota, no standard mechanism to acquire and report outcome data related to interprofessional education and collaborative practice and its effect on triple aim outcomes existed. This article describes the development and adoption of the National Center Data Repository (NCDR) designed to capture data related to IPECP processes and outcomes to support analyses of the relationship of IPECP on the Triple Aim. The data collection methods, web-based survey design and implementation process are discussed. The implications of this informatics work to the field of IPECP and health care quality and safety include creating standardized capacity to describe interprofessional practice and measure outcomes connecting interprofessional education and collaborative practice to the triple aim within and across sites/settings, leveraging an accessible data collection process using user friendly web-based survey design to support large data scholarship and instrument testing, and establishing standardized data elements and variables that can potentially lead to enhancements to national/international information system and academic accreditation standards to further team-based, interprofessional, collaborative research in the field. PMID:26652631

  8. The National United States Center Data Repository: Core essential interprofessional practice & education data enabling triple aim analytics

    PubMed Central

    Pechacek, Judith; Shanedling, Janet; Lutfiyya, May Nawal; Brandt, Barbara F.; Cerra, Frank B.; Delaney, Connie White

    2015-01-01

    Abstract Understanding the impact that interprofessional education and collaborative practice (IPECP) might have on triple aim patient outcomes is of high interest to health care providers, educators, administrators, and policy makers. Before the work undertaken by the National Center for Interprofessional Practice and Education at the University of Minnesota, no standard mechanism to acquire and report outcome data related to interprofessional education and collaborative practice and its effect on triple aim outcomes existed. This article describes the development and adoption of the National Center Data Repository (NCDR) designed to capture data related to IPECP processes and outcomes to support analyses of the relationship of IPECP on the Triple Aim. The data collection methods, web-based survey design and implementation process are discussed. The implications of this informatics work to the field of IPECP and health care quality and safety include creating standardized capacity to describe interprofessional practice and measure outcomes connecting interprofessional education and collaborative practice to the triple aim within and across sites/settings, leveraging an accessible data collection process using user friendly web-based survey design to support large data scholarship and instrument testing, and establishing standardized data elements and variables that can potentially lead to enhancements to national/international information system and academic accreditation standards to further team-based, interprofessional, collaborative research in the field. PMID:26652631

  9. Analytic magnetotelluric responses to a two-segment model with axially anisotropic conductivity structures overlying a perfect conductor

    NASA Astrophysics Data System (ADS)

    Qin, Linjiang; Yang, Changfu

    2016-06-01

    The rocks in the crust and the upper mantle of the Earth are believed to exhibit electrical anisotropy to some extent. It is beneficial to further understand and recognize the propagation of the electromagnetic waves in the Earth by investigating the magnetotelluric (which is one of the main geophysical techniques to probe the deep structures in the Earth) responses of the media with anisotropic conductivity structures. In this study, we examine the magnetotelluric fields over an idealized 2-D model consisting of two segments with axially anisotropic conductivity structures overlying a perfect conductor basement by a quasi-static analytic approach. The resulting analytic solution could not only contribute to the electromagnetic induction theory in the anisotropic Earth but also serve as at least an initial standard solution which could be used to validate the reliability and accuracy of the numerical algorithms developed for modelling the magnetotelluric responses of the 2-D media with much more general anisotropic conductivity.

  10. Analytic magnetotelluric responses to a two-segment model with axially anisotropic conductivity structures overlying a perfect conductor

    NASA Astrophysics Data System (ADS)

    Linjiang, QIN; Changfu, YANG

    2016-03-01

    The rocks in the crust and the upper mantle of the Earth are believed to exhibit electrical anisotropy to some extent. It is beneficial to further understand and recognize the propagation of the electromagnetic waves in the Earth by investigating the magnetotelluric (which is one of the main geophysical techniques to probe the deep structures in the Earth) responses of the media with anisotropic conductivity structures. In the present study, we examine the magnetotelluric fields over an idealized 2-D model consisting of two segments with axially anisotropic conductivity structures overlying a perfect conductor basement by a quasi-static analytic approach. The resulting analytic solution could not only contribute to the electromagnetic induction theory in the anisotropic Earth but also serve as at least an initial standard solution which could be used to validate the reliability and accuracy of the numerical algorithms developed for modeling the magnetotelluric responses of the 2-D media with much more general anisotropic conductivity.

  11. 20 CFR 670.550 - What responsibilities do Job Corps centers have in assisting students with child care needs?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... for their dependent children. (b) Job Corps centers may operate on center child development programs... have in assisting students with child care needs? 670.550 Section 670.550 Employees' Benefits... have in assisting students with child care needs? (a) Job Corps centers are responsible...

  12. 20 CFR 670.550 - What responsibilities do Job Corps centers have in assisting students with child care needs?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... for their dependent children. (b) Job Corps centers may operate on center child development programs... have in assisting students with child care needs? 670.550 Section 670.550 Employees' Benefits... have in assisting students with child care needs? (a) Job Corps centers are responsible...

  13. A cell-centered Lagrangian finite volume approach for computing elasto-plastic response of solids in cylindrical axisymmetric geometries

    NASA Astrophysics Data System (ADS)

    Sambasivan, Shiv Kumar; Shashkov, Mikhail J.; Burton, Donald E.

    2013-03-01

    A finite volume cell-centered Lagrangian formulation is presented for solving large deformation problems in cylindrical axisymmetric geometries. Since solid materials can sustain significant shear deformation, evolution equations for stress and strain fields are solved in addition to mass, momentum and energy conservation laws. The total strain-rate realized in the material is split into an elastic and plastic response. The elastic and plastic components in turn are modeled using hypo-elastic theory. In accordance with the hypo-elastic model, a predictor-corrector algorithm is employed for evolving the deviatoric component of the stress tensor. A trial elastic deviatoric stress state is obtained by integrating a rate equation, cast in the form of an objective (Jaumann) derivative, based on Hooke's law. The dilatational response of the material is modeled using an equation of state of the Mie-Grüneisen form. The plastic deformation is accounted for via an iterative radial return algorithm constructed from the J2 von Mises yield condition. Several benchmark example problems with non-linear strain hardening and thermal softening yield models are presented. Extensive comparisons with representative Eulerian and Lagrangian hydrocodes in addition to analytical and experimental results are made to validate the current approach.

  14. A Micro-Level Event-Centered Approach to Investigating Armed Conflict and Population Responses

    PubMed Central

    Williams, Nathalie E.; Ghimire, Dirgha J.; Axinn, William G.; Jennings, Elyse A.; Pradhan, Meeta S.

    2012-01-01

    In this article, we construct and test a micro-level event-centered approach to the study of armed conflict and behavioral responses in the general population. Event-centered approaches have been successfully used in the macro-political study of armed conflict but have not yet been adopted in micro-behavioral studies. The micro-level event-centered approach that we advocate here includes decomposition of a conflict into discrete political and violent events, examination of the mechanisms through which they affect behavior, and consideration of differential risks within the population. We focus on two mechanisms: instability and threat of harm. We test this approach empirically in the context of the recent decade-long armed conflict in Nepal, using detailed measurements of conflict-related events and a longitudinal study of first migration, first marriage, and first contraceptive use. Results demonstrate that different conflict-related events independently shaped migration, marriage, and childbearing and that they can simultaneously influence behaviors in opposing directions. We find that violent events increased migration, but political events slowed migration. Both violent and political events increased marriage and contraceptive use net of migration. Overall, this micro-level event-centered approach yields a significant advance for the study of how armed conflict affects civilian behavioral responses. PMID:22911154

  15. ANALYTICAL COMPUTATION OF THE LYOT CORONAGRAPH RESPONSE TO AN EXTENDED SOURCE

    SciTech Connect

    Ferrari, Andre; Aime, Claude

    2010-01-01

    This paper gives analytical expressions of the intensity in a Lyot coronagraph when the object is a resolved uniform disk. Intensities are given inside the Lyot stop and in the final plane. The derivation relies on the decomposition of the impinging waves on Zernike functions which allows the computation of the expansion of the intensities on infinite series. The expression in the final plane assumes that the sizes of the Lyot stop and the pupil are the same. An analysis of the truncation error is provided. These expressions are validated by computer simulations which makes it possible to recover known results such as the so-called diffraction ring observed by solar astronomers inside the Lyot stop. These analytical results and simulations bring deeper insight into the understanding of a Lyot coronagraph, for example, the fact that although the geometrical image of the source is behind the mask, a ghost image of the source can still be observed in the final plane.

  16. Domains of analyticity for response solutions in strongly dissipative forced systems

    SciTech Connect

    Corsi, Livia E-mail: feola@mat.uniroma1.it; Feola, Roberto E-mail: feola@mat.uniroma1.it; Gentile, Guido E-mail: feola@mat.uniroma1.it

    2013-12-15

    We study the ordinary differential equation εx{sup ¨}+x{sup .}+εg(x)=εf(ωt), where g and f are real-analytic functions, with f quasi-periodic in t with frequency vector ω. If c{sub 0}∈R is such that g(c{sub 0}) equals the average of f and g′(c{sub 0}) ≠ 0, under very mild assumptions on ω there exists a quasi-periodic solution close to c{sub 0} with frequency vector ω. We show that such a solution depends analytically on ε in a domain of the complex plane tangent more than quadratically to the imaginary axis at the origin.

  17. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... Center or Centers for Research in Vocational Education? 403.207 Section 403.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the...

  18. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... Center or Centers for Research in Vocational Education? 403.207 Section 403.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the...

  19. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... Center or Centers for Research in Vocational Education? 403.207 Section 403.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the...

  20. 34 CFR 403.207 - What are the State's responsibilities to the National Center or Centers for Research in...

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... Center or Centers for Research in Vocational Education? 403.207 Section 403.207 Education Regulations of the Offices of the Department of Education (Continued) OFFICE OF VOCATIONAL AND ADULT EDUCATION, DEPARTMENT OF EDUCATION STATE VOCATIONAL AND APPLIED TECHNOLOGY EDUCATION PROGRAM What Are the...

  1. Five key pillars of an analytics center of excellence, which are required to manage populations and transform organizations into the next era of health care.

    PubMed

    Reichert, Jim; Furlong, Gerry

    2014-01-01

    Acute care facilities are experiencing fiscal challenges as noted by decreasing admissions and lower reimbursement creating an unsustainable fiscal environment as we move into the next era of health care. This situation necessitates a strategy to move away from acting solely on hunches and instinct to using analytics to become a truly data-driven organization that identifies opportunities within patient populations to improve the quality and efficiency of care across the continuum. A brief overview of knowledge management philosophies will be provided and how it is used to enable organizations to leverage data, information, and knowledge for operational transformation leading to improved outcomes. This article outlines the 5 key pillars of an Analytics Center of Excellence; governance, organizational structure, people, process, and technology, that are foundational to the development of this strategy. While culture is the most important factor to achieve organizational transformation and improved care delivery, it is the 5 pillars of the ACoE that will enable the culture shift necessary to become a truly data-driven organization and thus achieve transformation into the next era of health care. PMID:24569763

  2. Polyanhydride Nanovaccines Induce Germinal Center B Cell Formation and Sustained Serum Antibody Responses.

    PubMed

    Vela Ramirez, Julia E; Tygrett, Lorraine T; Hao, Jihua; Habte, Habtom H; Cho, Michael W; Greenspan, Neil S; Waldschmidt, Thomas J; Narasimhan, Balaji

    2016-06-01

    Biodegradable polymeric nanoparticle-based subunit vaccines have shown promising characteristics by enhancing antigen presentation and inducing protective immune responses when compared with soluble protein. Specifically, polyanhydride nanoparticle-based vaccines (i.e., nanovaccines) have been shown to successfully encapsulate and release antigens, activate B and T cells, and induce both antibody- and cell-mediated immunity towards a variety of immunogens. One of the characteristics of strong thymus-dependent antibody responses is the formation of germinal centers (GC) and the generation of GC B cells, which is part of the T helper cell driven cellular response. In order to further understand the role of nanovaccines in the induction of antigen-specific immune responses, their ability to induce germinal center B cell formation and isotype switching and the effects thereof on serum antibody responses were investigated in these studies. Polyanhydride nanovaccines based on 1,6-bis(p-carboxyphenoxy)hexane and 1,8-bis(p-carboxyphenoxy)-3,6-dioxaoctane were used to subcutaneously administer a viral antigen. GC B cell formation and serum antibody responses induced by the nanovaccines were compared to that induced by alum-based vaccine formulations. It was demonstrated that a single dose of polyanhydride nanovaccines resulted in the formation of robust GCs and serum antibody in comparison to that induced by the alum-based formulation. This was attributed to the sustained release of antigen provided by the nanovaccines. When administered in a multiple dose regimen, the highest post-immunization titer and GC B cell number was enhanced, and the immune response induced by the nanovaccines was further sustained. These studies provide foundational information on the mechanism of action of polyanhydride nanovaccines. PMID:27319223

  3. Regulation of germinal center responses and B-cell memory by the chromatin modifier MOZ.

    PubMed

    Good-Jacobson, Kim L; Chen, Yunshun; Voss, Anne K; Smyth, Gordon K; Thomas, Tim; Tarlinton, David

    2014-07-01

    Memory B cells and long-lived bone marrow-resident plasma cells maintain humoral immunity. Little is known about the intrinsic mechanisms that are essential for forming memory B cells or endowing them with the ability to rapidly differentiate upon reexposure while maintaining the population over time. Histone modifications have been shown to regulate lymphocyte development, but their role in regulating differentiation and maintenance of B-cell subsets during an immune response is unclear. Using stage-specific deletion of monocytic leukemia zinc finger protein (MOZ), a histone acetyltransferase, we demonstrate that mutation of this chromatin modifier alters fate decisions in both primary and secondary responses. In the absence of MOZ, germinal center B cells were significantly impaired in their ability to generate dark zone centroblasts, with a concomitant decrease in both cell-cycle progression and BCL-6 expression. In contrast, there was increased differentiation to IgM and low-affinity IgG1(+) memory B cells. The lack of MOZ affected the functional outcome of humoral immune responses, with an increase in secondary germinal centers and a corresponding decrease in secondary high-affinity antibody-secreting cell formation. Therefore, these data provide strong evidence that manipulating epigenetic modifiers can regulate fate decisions during humoral responses, and thus could be targeted for therapeutic intervention. PMID:24979783

  4. Analytical Microscopy

    SciTech Connect

    Not Available

    2006-06-01

    In the Analytical Microscopy group, within the National Center for Photovoltaic's Measurements and Characterization Division, we combine two complementary areas of analytical microscopy--electron microscopy and proximal-probe techniques--and use a variety of state-of-the-art imaging and analytical tools. We also design and build custom instrumentation and develop novel techniques that provide unique capabilities for studying materials and devices. In our work, we collaborate with you to solve materials- and device-related R&D problems. This sheet summarizes the uses and features of four major tools: transmission electron microscopy, scanning electron microscopy, the dual-beam focused-ion-beam workstation, and scanning probe microscopy.

  5. All Source Solution Decision Support Products Created for Stennis Space Center in Response to Hurricane Katrina

    NASA Technical Reports Server (NTRS)

    Ross, Kenton W.; Graham, William D.

    2007-01-01

    In the aftermath of Hurricane Katrina and in response to the needs of SSC (Stennis Space Center), NASA required the generation of decision support products with a broad range of geospatial inputs. Applying a systems engineering approach, the NASA ARTPO (Applied Research and Technology Project Office) at SSC evaluated the Center's requirements and source data quality. ARTPO identified data and information products that had the potential to meet decision-making requirements; included were remotely sensed data ranging from high-spatial-resolution aerial images through high-temporal-resolution MODIS (Moderate Resolution Imaging Spectroradiometer) products. Geospatial products, such as FEMA's (Federal Emergency Management Agency's) Advisory Base Flood Elevations, were also relevant. Where possible, ARTPO applied SSC calibration/validation expertise to both clarify the quality of various data source options and to validate that the inputs that were finally chosen met SSC requirements. ARTPO integrated various information sources into multiple decision support products, including two maps: Hurricane Katrina Inundation Effects at Stennis Space Center (highlighting surge risk posture) and Vegetation Change In and Around Stennis Space Center: Katrina and Beyond (highlighting fire risk posture).

  6. Community Environmental Response Facilitation Act (CERFA) report, Former Army Reserve Center, Gaithersburg, Maryland. Final report

    SciTech Connect

    Hacker, G.; Walters, G.; Ward, L.

    1994-04-01

    This report presents the results of the Community Environmental Response Facilitation Act (CERFA) conducted by Environmental Resources Management (ERM) at the former Army Reserve Center, Gaithersburg (ARC), a U.S. Government property selected for closure by the Base Realignment and Closure (BRAC) Commission. Under CERFA, Federal agencies are required to identity expeditiously real property that can be immediately reused and redeveloped. Satisfying this objective requires the identification of real property where no hazardous substances or petroleum products, regulated by the Comprehensive Environmental Response, Compensation, and Liability Act (CERCLA), were stored for one year or more, known to have been released, or disposed. ARC is an 18-acre site located in Gaithersburg, Maryland. ARC was used for a variety of activities from 1955-1986. has served as a Nike Missile Control Site, as a communications and electronics research facility, and as an Army Reserve Center. Activities of environmental concern were mainly associated with construction, testing, and maintenance of electronic systems. The site has been vacant since 1986. Former Army Reserve Center, Gaithersburg, CERFA, Base closure, BRAC.

  7. Development of a simplified analytical method for representing material cyclic response

    NASA Technical Reports Server (NTRS)

    Moreno, V.

    1983-01-01

    Development of a simplified method for estimating structural inelastic stress and strain response to cyclic thermal loading is presented. The method assumes that high temperature structural response is the sum of time independent plastic and time dependent elastic/creep components. The local structural stress and strain response predicted by linear elastic analysis is modified by the simplified method to predict the inelastic response. The results with simulations by a nonlinear finite element analysis and used time independent plasticity and unified time dependent material model are compared.

  8. A Note on the Relation between Factor Analytic and Item Response Theory Models

    ERIC Educational Resources Information Center

    Kamata, Akihito; Bauer, Daniel J.

    2008-01-01

    The relations among several alternative parameterizations of the binary factor analysis model and the 2-parameter item response theory model are discussed. It is pointed out that different parameterizations of factor analysis model parameters can be transformed into item response model theory parameters, and general formulas are provided.…

  9. Analytical Prediction of the Seismic Response of a Reinforced Concrete Containment Vessel

    SciTech Connect

    James, R.J.; Rashid, Y.R.; Cherry, J.L.; Chokshi, N.; Tsurumaki, S.

    1999-03-19

    Under the sponsorship of the Ministry of International Trade and Industry (MITI) of Japan, the Nuclear Power Engineering Corporation (NUPEC) is investigating the seismic behavior of a Reinforced Concrete Containment Vessel (RCCV) through scale-model testing using the high-performance shaking table at the Tadotsu Engineering Laboratory. A series of tests representing design-level seismic ground motions was initially conducted to gather valuable experimental measurements for use in design verification. Additional tests will be conducted with increasing amplifications of the seismic input until a structural failure of the test model occurs. In a cooperative program with NUPEC, the US Nuclear Regulatory Commission (USNRC), through Sandia National Laboratories (SNL), is conducting analytical research on the seismic behavior of RCCV structures. As part of this program, pretest analytical predictions of the model tests are being performed. The dynamic time-history analysis utilizes a highly detailed concrete constitutive model applied to a three-dimensional finite element representation of the test structure. This paper describes the details of the analysis model and provides analysis results.

  10. Analytical simulation of nonlinear response to seismic test excitations of HDR-VKL (Heissdampfreaktor-Versuchskreislauf) piping system

    SciTech Connect

    Srinivasan, M.G.; Kot, C.A. ); Mojtahed, M. . Dept. of Mechanical Engineering)

    1991-01-01

    The paper describes the analytical modeling, calculations, and results of the posttest nonlinear simulation of high-level seismic testing of the VKL piping system at the HDR Test Facility in Germany. One of the objectives of the tests was to evaluate analytical methods for calculating the nonlinear response of realistic piping systems subjected to high-level seismic excitation that would induce significant plastic deformation. Two out of the six different pipe-support configurations, (ranging from a stiff system with struts and snubbers to a very flexible system with practically no seismic supports), subjected to simulated earthquakes, were tested at very high levels. The posttest nonlinear calculations cover the KWU configuration, a reasonably compliant system with only rigid struts. Responses for 800% safe-shutdown-earthquake loading were calculated using the NONPIPE code. The responses calculated with NONPIPE were found generally to have the same time trends as the measurements but contained under-, over-, and correct estimates of peak values, almost in equal proportions. The only exceptions were the peak strut forces, which were underestimated as a group. The scatter in the peak value estimate of displacements and strut forces was smaller than that for the strains. The possible reasons for the differences and the effort on further analysis are discussed.

  11. NOAA/West coast and Alaska Tsunami warning center Atlantic Ocean response criteria

    USGS Publications Warehouse

    Whitmore, P.; Refidaff, C.; Caropolo, M.; Huerfano-Moreno, V.; Knight, W.; Sammler, W.; Sandrik, A.

    2009-01-01

    West Coast/Alaska Tsunami Warning Center (WCATWC) response criteria for earthquakesoccurring in the Atlantic and Caribbean basins are presented. Initial warning center decisions are based on an earthquake's location, magnitude, depth, distance from coastal locations, and precomputed threat estimates based on tsunami models computed from similar events. The new criteria will help limit the geographical extent of warnings and advisories to threatened regions, and complement the new operational tsunami product suite. Criteria are set for tsunamis generated by earthquakes, which are by far the main cause of tsunami generation (either directly through sea floor displacement or indirectly by triggering of sub-sea landslides).The new criteria require development of a threat data base which sets warning or advisory zones based on location, magnitude, and pre-computed tsunami models. The models determine coastal tsunami amplitudes based on likely tsunami source parameters for a given event. Based on the computed amplitude, warning and advisory zones are pre-set.

  12. Gas chromatographic/mass spectrometric analyses of unknown analytical response in imported Fava beans: 4-chloro-6-methoxyindole.

    PubMed

    Petzinger, G; Barry, T L; Roach, J A; Musser, S M; Sphon, J

    1995-01-01

    A halogenated unidentified analytical response (UAR) was encountered in a number of imported Fava bean samples during the Food and Drug Administration's routine pesticide-monitoring program. Gas chromatographic/mass spectrometric (GC/MS) analyses identified the halogenated component as 4-chloro-6-methoxyindole, a naturally occurring promutagen in Fava beans that has been linked to incidents of gastric cancer. Data from electron impact, positive and negative chemical ionization, collision-induced dissociation, and deuteration studies of this compound are presented, along with GC retention time data. PMID:7756907

  13. Simulation of population response to ionizing radiation in an ecosystem with a limiting resource--Model and analytical solutions.

    PubMed

    Sazykina, Tatiana G; Kryshev, Alexander I

    2016-01-01

    A dynamic mathematical model is formulated, predicting the development of radiation effects in a generic animal population, inhabiting an elemental ecosystem 'population-limiting resource'. Differential equations of the model describe the dynamic responses to radiation damage of the following population characteristics: gross biomass; intrinsic fractions of healthy and reversibly damaged tissues in biomass; intrinsic concentrations of the self-repairing pool and the growth factor; and amount of the limiting resource available in the environment. Analytical formulae are found for the steady states of model variables as non-linear functions of the dose rate of chronic radiation exposure. Analytical solutions make it possible to predict the expected severity of radiation effects in a model ecosystem, including such endpoints as morbidity, mortality, life shortening, biosynthesis, and population biomass. Model parameters are selected from species data on lifespan, physiological growth and mortality rates, and individual radiosensitivity. Thresholds for population extinction can be analytically calculated for different animal species, examples are provided for generic mice and wolf populations. The ecosystem model demonstrates a compensatory effect of the environment on the development of radiation effects in wildlife. The model can be employed to construct a preliminary scale 'radiation exposure-population effects' for different animal species; species can be identified, which are vulnerable at a population level to chronic radiation exposure. PMID:26408836

  14. Spatially variable water table recharge and the hillslope hydrologic response: Analytical solutions to the linearized hillslope Boussinesq equation

    NASA Astrophysics Data System (ADS)

    Dralle, David N.; Boisramé, Gabrielle F. S.; Thompson, Sally E.

    2014-11-01

    The linearized hillslope Boussinesq equation, introduced by Brutsaert (1994), describes the dynamics of saturated, subsurface flow from hillslopes with shallow, unconfined aquifers. In this paper, we use a new analytical technique to solve the linearized hillslope Boussinesq equation to predict water table dynamics and hillslope discharge to channels. The new solutions extend previous analytical treatments of the linearized hillslope Boussinesq equation to account for the impact of spatiotemporal heterogeneity in water table recharge. The results indicate that the spatial character of recharge may significantly alter both steady state subsurface storage characteristics and the transient hillslope hydrologic response, depending strongly on similarity measures of controls on the subsurface flow dynamics. Additionally, we derive new analytical solutions for the linearized hillslope-storage Boussinesq equation and explore the interaction effects of recharge structure and hillslope morphology on water storage and base flow recession characteristics. A theoretical recession analysis, for example, demonstrates that decreasing the relative amount of downslope recharge has a similar effect as increasing hillslope convergence. In general, the theory suggests that recharge heterogeneity can serve to diminish or enhance the hydrologic impacts of hillslope morphology.

  15. IQ Is Not Strongly Related to Response to Reading Instruction: A Meta-Analytic Interpretation

    ERIC Educational Resources Information Center

    Stuebing, Karla K.; Barth, Amy E.; Molfese, Peter J.; Weiss, Brandon; Fletcher, Jack M.

    2009-01-01

    A meta-analysis of 22 studies evaluating the relation of different assessments of IQ and intervention response did not support the hypothesis that IQ is an important predictor of response to instruction. We found an R[superscript 2] of 0.03 in models with IQ and the autoregressor as predictors and a unique lower estimated R[superscript 2] of 0.006…

  16. Motion of soliton center of interactional solitons in nonlinear media with an exponential nonlocal response

    NASA Astrophysics Data System (ADS)

    Dai, Zhiping; Yang, Zhenjun; Ling, Xiaohui; Zhang, Shumin; Pang, Zhaoguang; Li, Jianxing

    2016-05-01

    The motion of two interactional solitons is investigated in nonlinear media with an exponential nonlocal response. A differential equation describing the motion trajectories of soliton center is proposed. Some numerical simulations are performed to illustrate the characteristics of the motion trajectories. The results show that the trajectories always oscillate periodically. However, if the two solitons are launched with a relative inclined angle which is larger than a critical value, they do not collide any more but diverge from each other. The critical angle is also given.

  17. Analytical design and evaluation of an active control system for helicopter vibration reduction and gust response alleviation

    NASA Technical Reports Server (NTRS)

    Taylor, R. B.; Zwicke, P. E.; Gold, P.; Miao, W.

    1980-01-01

    An analytical study was conducted to define the basic configuration of an active control system for helicopter vibration and gust response alleviation. The study culminated in a control system design which has two separate systems: narrow band loop for vibration reduction and wider band loop for gust response alleviation. The narrow band vibration loop utilizes the standard swashplate control configuration to input controller for the vibration loop is based on adaptive optimal control theory and is designed to adapt to any flight condition including maneuvers and transients. The prime characteristics of the vibration control system is its real time capability. The gust alleviation control system studied consists of optimal sampled data feedback gains together with an optimal one-step-ahead prediction. The prediction permits the estimation of the gust disturbance which can then be used to minimize the gust effects on the helicopter.

  18. An analytic model for the response of a CZT detector in diagnostic energy dispersive x-ray spectroscopy

    SciTech Connect

    LeClair, Robert J.; Wang Yinkun; Zhao Peiying; Boileau, Michel; Wang, Lilie; Fleurot, Fabrice

    2006-05-15

    A CdZnTe detector (CZTD) can be very useful for measuring diagnostic x-ray spectra. The semiconductor detector does, however, exhibit poor hole transport properties and fluorescence generation upon atomic de-excitations. This article describes an analytic model to characterize these two phenomena that occur when a CZTD is exposed to diagnostic x rays. The analytical detector response functions compare well with those obtained via Monte Carlo calculations. The response functions were applied to 50, 80, and 110 kV x-ray spectra. Two 50 kV spectra were measured; one with no filtration and the other with 1.35 mm Al filtration. The unfiltered spectrum was numerically filtered with 1.35 mm of Al in order to see whether the recovered spectrum resembled the filtered spectrum actually measured. A deviation curve was obtained by subtracting one curve from the other on an energy bin by bin basis. The deviation pattern fluctuated around the zero line when corrections were applied to both spectra. Significant deviations from zero towards the lower energies were observed when the uncorrected spectra were used. Beside visual observations, the exposure obtained using the numerically attenuated unfiltered beam was compared to the exposure calculated with the actual filtered beam. The percent differences were 0.8% when corrections were applied and 25% for no corrections. The model can be used to correct diagnostic x-ray spectra measured with a CdZnTe detector.

  19. Analytical ultrasonics for evaluation of composite materials response. Part 2: Generation and detection

    NASA Technical Reports Server (NTRS)

    Duke, J. C., Jr.; Henneke, E. G., II

    1986-01-01

    To evaluate the response of composite materials, it is imperative that the input excitation as well as the observed output be well characterized. This characterization ideally should be in terms of displacements as a function of time with high spatial resolution. Additionally, the ability to prescribe these features for the excitation is highly desirable. Various methods for generating and detecting ultrasound in advanced composite materials are examined. Characterization and tailoring of input excitation is considered for contact and noncontact, mechanical, and electromechanical devices. Type of response as well as temporal and spatial resolution of detection methods are discussed as well. Results of investigations at Virginia Tech in application of these techniques to characterizing the response of advanced composites are presented.

  20. An analytical study of the response of a constant-attitude aircraft to atmospheric turbulence

    NASA Technical Reports Server (NTRS)

    Smetana, F. O.; Carden, R. K.

    1973-01-01

    A light airplane equipped with an automatic control system which drives large wing flaps and the stabilator so as to produce a constant pitch attitude in all flight modes was analyzed for its response to a specific gust. The aircraft was also equipped with a bank-angle steering, zero sideslip automatic control system which was studied for its effectiveness in suppressing a specific lateral gust. The gusts were assumed to be comprised of 200 lateral and 400 vertical sinusoids. Each was used to excite the controlled aircraft and the time response to the sum of all sinusoids was plotted. The assumption was that the gust may be treated as stationary in space but variable in time rather than the reverse. Results indicate that such a control system can suppress vertical gusts up to the limit of control authority. Either the lateral accelerations or the yawing velocity response to lateral gusts can be suppressed with this system but not both simultaneously.

  1. Project plan, Hazardous Materials Management and Emergency Response Training Center: Project 95L-EWT-100

    SciTech Connect

    Borgeson, M.E.

    1994-11-09

    The Hazardous Materials Management and Emergency Response (HAMMER) Training Center will provide for classroom lectures and hands-on practical training in realistic situations for workers and emergency responders who are tasked with handling and cleanup of toxic substances. The primary objective of the HAMMER project is to provide hands-on training and classroom facilities for hazardous material workers and emergency responders. This project will also contribute towards complying with the planning and training provisions of recent legislation. In March 1989 Title 29 Code of Federal Regulations Occupational Safety and Health Administration 1910 Rules and National Fire Protection Association Standard 472 defined professional requirements for responders to hazardous materials incidents. Two general types of training are addressed for hazardous materials: training for hazardous waste site workers and managers, and training for emergency response organizations.

  2. Psychiatry department response to the Boston Marathon bombings within a level-1 trauma center.

    PubMed

    Oser, Megan; Shah, Sejal B; Gitlin, David

    2015-01-01

    In this article we present how the consultation-liaison and psychology divisions of an academic medical center's Department of Psychiatry responded in the first week after the Boston Marathon bombings, specifically in the context of disaster response guidelines and evidence-based approaches to acute trauma. Since the department had to address several complicated matters at multiple levels within the hospital system, we highlight unexpected issues unique to this particular event as they arose within the primary domains of our involvement. This article aims to (1) provide a descriptive analysis of how we enacted disaster and trauma guidelines and evidence-based care within a hospital setting, (2) shed light on the unique and unexpected administrative and systemic issues encountered in our response, and (3) discuss lessons learned, including opportunities to improve trauma-related care. PMID:25943313

  3. Rapid-Response Parenting Intervention in Diagnostic Centers as a Patient-Centered Innovation for Autism Spectrum Disorders

    ERIC Educational Resources Information Center

    McMillin, Stephen Edward; Bultas, Margaret W.; Wilmott, Jennifer; Grafeman, Sarah; Zand, Debra H.

    2015-01-01

    Parents of children newly diagnosed with autism spectrum disorders are a high-need population for whom skills-based parenting interventions likely help. Diagnostic centers are compelling locations to deliver parenting interventions because families are served in an accessible location and at a time they receive overwhelming treatment…

  4. Assessing the Immunogenic Response of a Single Center's Pneumococcal Vaccination Protocol in Sickle Cell Disease.

    PubMed

    Santoro, Jonathan D; Myers, Leann; Kanter, Julie

    2016-04-01

    Sickle cell disease (SCD) is the most common inherited hematologic disorder in the United States. Patients with SCD are at increased risk of invasive pneumococcal disease and are reliant on both early penicillin prophylaxis and antipneumococcal vaccination for prevention of infection. Although studies examining vaccine response have demonstrated a drop-off of titer response after 3 years, an optimal vaccination regimen has not been identified. Our study sought to assess the immunogenicity of our center's pneumococcal vaccination strategy, which included Prevnar (PCV-7) (before the introduction of PCV-13) followed by Pneumovax (PPV-23) given routinely at 2 and 5 years of age and then every 5 years thereafter. Our goal was to assess vaccine response in a population of patients with SCD who had received vaccines according to this regimen using multiplex bead analysis. Our study demonstrated a significant percentage of persons with SCD do not maintain a sufficient vaccination response to PPV-23 for 5 years. Our study revealed that only 36% of patients had protective levels of antipneumococcal antibody titers at an average of 37 months after vaccination. Most alarmingly, within the group of patients with subtherapeutic titers, 64% demonstrated vaccine response to <25% of the tested serotypes. These findings were significantly associated with duration of time since last vaccine administration, but the mean age of lack of response was below the 3-year window where vaccine response was previously reported to wane. Our results indicate antipneumococcal immunity may not be optimally maintained using this vaccination strategy in patients with SCD leaving them vulnerable to invasive pneumococcal disease. Many pediatric hematologists stop prophylactic penicillin at 5 years of age making these results alarming. We recommend further investigation into an optimal vaccine schedule and monitoring of antipneumococcal titers in at-risk patients. PMID:26886376

  5. Relationships among Classical Test Theory and Item Response Theory Frameworks via Factor Analytic Models

    ERIC Educational Resources Information Center

    Kohli, Nidhi; Koran, Jennifer; Henn, Lisa

    2015-01-01

    There are well-defined theoretical differences between the classical test theory (CTT) and item response theory (IRT) frameworks. It is understood that in the CTT framework, person and item statistics are test- and sample-dependent. This is not the perception with IRT. For this reason, the IRT framework is considered to be theoretically superior…

  6. Assessing Acquiescence in Binary Responses: IRT-Related Item-Factor-Analytic Procedures

    ERIC Educational Resources Information Center

    Ferrando, Pere J.; Condon, Lorena

    2006-01-01

    This article proposes procedures for assessing acquiescence in a balanced set of binary personality items. These procedures are based on the bidimensional item-factor analysis model, which is an alternative parameterization of the bidimensional 2-parameter normal-ogive item response theory model. First the rationale and general approach are…

  7. Crisis Preparedness and Response for Schools: An Analytical Study of Punjab, Pakistan

    ERIC Educational Resources Information Center

    Javed, Muhammad Latif; Niazi, Hamid Khan

    2015-01-01

    This research study aims to analyze the Preparedness and Response to crises in School Education department at secondary level in Punjab, Pakistan. This was done through the experiences and views of District Education Officers (DEOs), Head of Schools and Secondary School Teachers (SST). The purpose of the study was not only to examine preparedness…

  8. NOAA/West Coast and Alaska Tsunami Warning Center Pacific Ocean response criteria

    USGS Publications Warehouse

    Whitmore, P.; Benz, H.; Bolton, M.; Crawford, G.; Dengler, L.; Fryer, G.; Goltz, J.; Hansen, R.; Kryzanowski, K.; Malone, S.; Oppenheimer, D.; Petty, E.; Rogers, G.; Wilson, Jim

    2008-01-01

    New West Coast/Alaska Tsunami Warning Center (WCATWC) response criteria for earthquakes occurring in the Pacific basin are presented. Initial warning decisions are based on earthquake location, magnitude, depth, and - dependent on magnitude - either distance from source or precomputed threat estimates generated from tsunami models. The new criteria will help limit the geographical extent of warnings and advisories to threatened regions, and complement the new operational tsunami product suite. Changes to the previous criteria include: adding hypocentral depth dependence, reducing geographical warning extent for the lower magnitude ranges, setting special criteria for areas not well-connected to the open ocean, basing warning extent on pre-computed threat levels versus tsunami travel time for very large events, including the new advisory product, using the advisory product for far-offshore events in the lower magnitude ranges, and specifying distances from the coast for on-shore events which may be tsunamigenic. This report sets a baseline for response criteria used by the WCATWC considering its processing and observational data capabilities as well as its organizational requirements. Criteria are set for tsunamis generated by earthquakes, which are by far the main cause of tsunami generation (either directly through sea floor displacement or indirectly by triggering of slumps). As further research and development provides better tsunami source definition, observational data streams, and improved analysis tools, the criteria will continue to adjust. Future lines of research and development capable of providing operational tsunami warning centers with better tools are discussed.

  9. Experimental, numerical, and analytical studies on the seismic response of steel-plate concrete (SC) composite shear walls

    NASA Astrophysics Data System (ADS)

    Epackachi, Siamak

    The seismic performance of rectangular steel-plate concrete (SC) composite shear walls is assessed for application to buildings and mission-critical infrastructure. The SC walls considered in this study were composed of two steel faceplates and infill concrete. The steel faceplates were connected together and to the infill concrete using tie rods and headed studs, respectively. The research focused on the in-plane behavior of flexure- and flexure-shear-critical SC walls. An experimental program was executed in the NEES laboratory at the University at Buffalo and was followed by numerical and analytical studies. In the experimental program, four large-size specimens were tested under displacement-controlled cyclic loading. The design variables considered in the testing program included wall thickness, reinforcement ratio, and slenderness ratio. The aspect ratio (height-to-length) of the four walls was 1.0. Each SC wall was installed on top of a re-usable foundation block. A bolted baseplate to RC foundation connection was used for all four walls. The walls were identified to be flexure- and flexure-shear critical. The progression of damage in the four walls was identical, namely, cracking and crushing of the infill concrete at the toes of the walls, outward buckling and yielding of the steel faceplates near the base of the wall, and tearing of the faceplates at their junctions with the baseplate. A robust finite element model was developed in LS-DYNA for nonlinear cyclic analysis of the flexure- and flexure-shear-critical SC walls. The DYNA model was validated using the results of the cyclic tests of the four SC walls. The validated and benchmarked models were then used to conduct a parametric study, which investigated the effects of wall aspect ratio, reinforcement ratio, wall thickness, and uniaxial concrete compressive strength on the in-plane response of SC walls. Simplified analytical models, suitable for preliminary analysis and design of SC walls, were

  10. Engineering Values Into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility.

    PubMed

    Sankar, Pamela L; Cho, Mildred K

    2015-01-01

    Recent experiments have been used to "edit" genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing the Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a "gene drive" that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments. PMID:26632356

  11. Simplified analytical procedures for representing material cyclic response. [for high temperature gas turbine engine analysis

    NASA Technical Reports Server (NTRS)

    Moreno, V.; Kaufman, A.

    1984-01-01

    Requirements for increased durability of gas turbine hot section structural components have made it necessary to place greater emphasis on accurate structural analysis and life prediction. Linear finite-element analysis is generally sufficient for structural analysis applications. However, for structures in the hot part of the engine, nonlinear structural analysis may be required under certain conditions for the accurate prediction of the local stress-strain response. Nonlinear finite element analysis represents a costly effort which is generally incompatible with the iterative nature of the design process. The present investigation is, therefore, concerned with two simplified procedures for estimating the local hysteretic response produced by cyclic thermal loading. These procedures reduce the need for nonlinear finite-element analysis.

  12. Analytical and numerical investigation of structural response of compliant wall materials, part 1

    NASA Technical Reports Server (NTRS)

    Balasubramanian, R.

    1978-01-01

    Surface motion of compliant walls in drag reduction experiments was analyzed. Critical comparison was made between the dynamic motion of the structure and the postulated mechanism of drag reduction. The spectrum of surface motion indicated that membranes over deep cavities respond at low frequencies and large wavelengths. The membrane over a deep cavity is therefore found not to yield the desired response predicted by the postulated mechanism. The membrane over a thin air gap is found to act as a wavelength chopper, and analysis of the nonlinear response of that compliant surface indicated its possible suitability for compliant wall experiments. Periodic structures are found to lock in the desired wavelengths of motion, and it was shown that at least in Kramer's initial experiments they produced high frequency surface motions. Laminated structures are found to be very ineffective as compliant models, except when there is no bonding between the membrane and the backing. Computer programs developed for these analyses are documented.

  13. Engineering Values into Genetic Engineering: A Proposed Analytic Framework for Scientific Social Responsibility

    PubMed Central

    Cho, Mildred K.

    2016-01-01

    Recent experiments have been used to “edit” genomes of various plant, animal and other species, including humans, with unprecedented precision. Furthermore, editing Cas9 endonuclease gene with a gene encoding the desired guide RNA into an organism, adjacent to an altered gene, could create a “gene drive” that could spread a trait through an entire population of organisms. These experiments represent advances along a spectrum of technological abilities that genetic engineers have been working on since the advent of recombinant DNA techniques. The scientific and bioethics communities have built substantial literatures about the ethical and policy implications of genetic engineering, especially in the age of bioterrorism. However, recent CRISPr/Cas experiments have triggered a rehashing of previous policy discussions, suggesting that the scientific community requires guidance on how to think about social responsibility. We propose a framework to enable analysis of social responsibility, using two examples of genetic engineering experiments. PMID:26632356

  14. Molecular tubes for lipid sensing: tube conformations control analyte selectivity and fluorescent response.

    PubMed

    Avetta, Christopher T; Shorthill, Berkeley J; Ren, Chun; Glass, Timothy E

    2012-01-20

    Two fluorescent sensors for lipids have been prepared and tested for detection of a number of hydrophobic compounds of varying shape and size. The data suggest that the two sensors have a different mode of fluorescent response. Yet, the two sensors are only different in the bridging group--one having a flexible amide and one having a rigid allyl bridge. The fluorescence data are explained based on a difference in conformation of the two sensors in aqueous solution. PMID:22263717

  15. An analytical solution for the elastoplastic response of a continuous fiber composite under uniaxial loading

    NASA Technical Reports Server (NTRS)

    Lee, Jong-Won; Allen, David H.

    1990-01-01

    A continuous fiber composite is modelled by a two-element composite cylinder in order to predict the elastoplastic response of the composite under a monotonically increasing tensile loading parallel to fibers. The fibers and matrix are assumed to be elastic-perfectly plastic materials obeying Hill's and Tresca's yield criteria, respectively. Here, the composite behavior when the fibers yield prior to the matrix is investigated.

  16. Metals and trace elements in feathers: A geochemical approach to avoid misinterpretation of analytical responses.

    PubMed

    Borghesi, Fabrizio; Migani, Francesca; Andreotti, Alessandro; Baccetti, Nicola; Bianchi, Nicola; Birke, Manfred; Dinelli, Enrico

    2016-02-15

    interpretation of the analytical results. PMID:26657393

  17. Effect of Phase on Human Responses to Vertical Whole-Body Vibration and SHOCK—ANALYTICAL Investigation

    NASA Astrophysics Data System (ADS)

    MATSUMOTO, Y.; GRIFFIN, M. J.

    2002-03-01

    The effect of the “phase” on human responses to vertical whole-body vibration and shock has been investigated analytically using alternative methods of predicting subjective responses (using r.m.s., VDV and various frequency weightings). Two types of phase have been investigated: the effect of the relative phase between two frequency components in the input stimulus, and the phase response of the human body. Continuous vibrations and shocks, based on half-sine and one-and-a-half-sine accelerations, each of which had two frequency components, were used as input stimuli. For the continuous vibrations, an effect of relative phase was found for the vibration dose value (VDV) when the ratio between two frequency components was three: about 12% variation in the VDV of the unweighted acceleration was possible by changing the relative phase. The effect of the phase response of the body represented by frequency weightings was most significant when the frequencies of two sinusoidal components were about 3 and 9 Hz. With shocks, the effect of relative phase was observed for all stimuli used. The variation in the r.m.s. acceleration and in the VDV caused by variations in the relative phase varied between 3 and 100%, depending on the nature of stimulus and the frequency weighting. The phase of the frequency weightings had a different effect on the r.m.s. and the VDV.

  18. Is harm reduction profitable? An analytical framework for corporate social responsibility based on an epidemic model of addictive consumption.

    PubMed

    Massin, Sophie

    2012-06-01

    This article aims to help resolve the apparent paradox of producers of addictive goods who claim to be socially responsible while marketing a product clearly identified as harmful. It advances that reputation effects are crucial in this issue and that determining whether harm reduction practices are costly or profitable for the producers can help to assess the sincerity of their discourse. An analytical framework based on an epidemic model of addictive consumption that includes a deterrent effect of heavy use on initiation is developed. This framework enables us to establish a clear distinction between a simple responsible discourse and genuine harm reduction practices and, among harm reduction practices, between use reduction practices and micro harm reduction practices. Using simulations based on tobacco sales in France from 1950 to 2008, we explore the impact of three corresponding types of actions: communication on damage, restraining selling practices and development of safer products on total sales and on the social cost. We notably find that restraining selling practices toward light users, that is, preventing light users from escalating to heavy use, can be profitable for the producer, especially at early stages of the epidemic, but that such practices also contribute to increase the social cost. These results suggest that the existence of a deterrent effect of heavy use on the initiation of the consumption of an addictive good can shed new light on important issues, such as the motivations for corporate social responsibility and the definition of responsible actions in the particular case of harm reduction. PMID:22475402

  19. Analytic derivative couplings in time-dependent density functional theory: Quadratic response theory versus pseudo-wavefunction approach

    SciTech Connect

    Zhang, Xing; Herbert, John M.

    2015-02-14

    We revisit the formalism for analytic derivative couplings between excited states in time-dependent density functional theory (TDDFT). We derive and implement these couplings using quadratic response theory, then numerically compare this response-theory formulation to couplings implemented previously based on a pseudo-wavefunction formalism and direct differentiation of the Kohn-Sham determinant. Numerical results, including comparison to full configuration interaction calculations, suggest that the two approaches perform equally well for many molecular systems, provided that the underlying DFT method affords accurate potential energy surfaces. The response contributions are found to be important for certain systems with high symmetry, but can be calculated with only a moderate increase in computational cost beyond what is required for the pseudo-wavefunction approach. In the case of spin-flip TDDFT, we provide a formal proof that the derivative couplings obtained using response theory are identical to those obtained from the pseudo-wavefunction formulation, which validates our previous implementation based on the latter formalism.

  20. Analytical calculation of in-plane response of plates with concentrated masses to impact and application to pyroshock simulation

    NASA Astrophysics Data System (ADS)

    Lacher, Alexander; Jüngel, Nikolas; von Wagner, Utz; Bäger, Annette

    2012-07-01

    In aerospace missions pyroshocks occur due to controlled explosions of ordnance devices enabling the functionality of space modules. These shocks result from deployment mechanisms or opening solar sails and can cause failures of electronic devices and structures. Thus, essential components for assuring the reliability of modules are pyroshock tests for the completion of which strict requirements by the aerospace administrations have to be met. One of them is the definition of a specific acceleration signal and, based on this, the Shock Response Spectrum (SRS) for each part. So far, there is rather empirical than analytical knowledge about producing desired SRS with mechanical impacts and its characteristics due to the variation of input parameters. In this paper a widespread testing procedure for far-field pyroshocks is discussed which is realized by the in-plane impact of a hammer pendulum on a plate including the test specimen. The mechanical model consists of the contact between a rigid sphere and a free deformable rectangular plate with attached masses including subsequent propagation and reflection of longitudinal waves. In order to allow for a prediction of the acceleration field and the corresponding SRS due to the impact the problem is solved semi-analytically by using Hertzian contact theory, the Galerkin-procedure and numerical integration in time domain. The in-plane problem has, to the best of the authors' knowledge, not yet been treated in the literature in the way presented. The results calculated are compared with experimental data showing very good coincidence and allowing for a fast prediction of far-field pyroshock tests due to the impact excitation by a hammer pendulum. Hence, the framework of this paper is an enrichment for the current state of the art considering analytical pyroshock simulation. By better understanding the effect of pyroshocks to one and two dimensional structures a reduction of costs as well as durations for testing procedures

  1. A reversible dual-response fluorescence switch for the detection of multiple analytes.

    PubMed

    Geng, Junlong; Liu, Ping; Liu, Bianhua; Guan, Guijian; Zhang, Zhongping; Han, Ming-Yong

    2010-03-22

    This paper reports a reversible dual fluorescence switch for the detection of a proton target and 2,4,6-trinitrotoluene (TNT) with opposite-response results, based on fluorophore derivatization of silica nanoparticles. Fluorescent silica nanoparticles were synthesized through modification of the surface with a nitrobenzoxadiazole (NBD) fluorophore and an organic amine to form a hybrid monolayer of fluorophores and amino ligands; the resultant nanoparticles showed different fluorescence responses to the proton target and TNT. Protonation of the amino ligands leads to fluorescence enhancement due to inhibition of photoinduced electron transfer (PET) between the amine and fluorophore. By contrast, addition of TNT results in fluorescence quenching because a fluorescence resonance energy transfer (FRET) happens between the NBD fluorophore and the formed TNT-amine complex. The fluorescence signal is reversible through washing with the proper solvents and the nanoparticles can be reused after centrifugal separation. Furthermore, these nanoparticles were assembled into chips on an etched silicon wafer for the detection of TNT and the proton target. The assembled chip can be used as a convenient indicator of herbicide (2,4-dichlorophenoxyacetic acid) and TNT residues with the use of only 10 microL of sample. The simple NBD-grafted silica nanoparticles reported here show a reversible signal and good assembly flexibility; thus, they can be applied in multianalyte detection. PMID:20151433

  2. An analytical/numerical correlation study of the multiple concentric cylinder model for the thermoplastic response of metal matrix composites

    NASA Technical Reports Server (NTRS)

    Pindera, Marek-Jerzy; Salzar, Robert S.; Williams, Todd O.

    1993-01-01

    The utility of a recently developed analytical micromechanics model for the response of metal matrix composites under thermal loading is illustrated by comparison with the results generated using the finite-element approach. The model is based on the concentric cylinder assemblage consisting of an arbitrary number of elastic or elastoplastic sublayers with isotropic or orthotropic, temperature-dependent properties. The elastoplastic boundary-value problem of an arbitrarily layered concentric cylinder is solved using the local/global stiffness matrix formulation (originally developed for elastic layered media) and Mendelson's iterative technique of successive elastic solutions. These features of the model facilitate efficient investigation of the effects of various microstructural details, such as functionally graded architectures of interfacial layers, on the evolution of residual stresses during cool down. The available closed-form expressions for the field variables can readily be incorporated into an optimization algorithm in order to efficiently identify optimal configurations of graded interfaces for given applications. Comparison of residual stress distributions after cool down generated using finite-element analysis and the present micromechanics model for four composite systems with substantially different temperature-dependent elastic, plastic, and thermal properties illustrates the efficacy of the developed analytical scheme.

  3. Analytical and numerical investigation of structural response of compliant wall materials, part 2

    NASA Technical Reports Server (NTRS)

    Balasubramanian, R.

    1978-01-01

    Theoretical analysis of an electrostatically driven wall system for a compliant wall drag reduction program is reported. The electrostatic wall system is capable of producing deflections of many orders greater than the wall thicknesses and at small wavelengths. An intermediate large response theory is used for structural analysis. The theoretical predictions are compared to bench test results, and good agreement between the two is obtained. The effects of aerodynamic loads and perturbation electric fields on the theoretical solutions are considered. It is shown that for very small wavelengths (lambda almost equals 2 mm) the aerodynamic effects can be estimated using potential theory without loss of accuracy, and the perturbation electric fields do not effect solutions as long as the deflections are less than one percent of the wavelength. Resonance effects for this type of structure are shown to be fairly small.

  4. Analytical and numerical investigation of structural response of compliant wall materials

    NASA Technical Reports Server (NTRS)

    Goglia, G. L.; Balasubramanian, R.

    1978-01-01

    Theoretical analysis of an electrostatically driven wall system for a compliant wall drag reduction program is reported. The electrostatic wall system is capable of producing deflections of many orders greater than the thicknesses and at small wavelengths. An intermediate large response theory was used for structural analysis. The theoretical predictions were compared to bench test results, and good agreement between the two was obtained. The effects of aerodynamic loads and perturbation electric fields on the theoretical solutions were considered. It was shown that for very small wavelengths (approximately 2mm) the aerodynamic effects can be estimated using potential theory without loss of accuracy, and the perturbation electric fields do not affect solutions as long as the deflections are less than one percent of the wavelength. Resonance effects for this type of structure were shown to be fairly small.

  5. Analytical and numerical investigation of structural response of compliant wall materials

    NASA Technical Reports Server (NTRS)

    Goglia, G. L.; Balasubramanian, R.

    1977-01-01

    Surface motion of compliant walls in drag reduction experiments was analyzed. The spectrum of surface motion indicates that membranes over deep cavities respond at low frequencies and large wavelengths. The membrane over a deep cavity is therefore found not to yield the desired reponse predicted by the postulated mechanism. The membrane over a thin air gap is found to act as a wavelength chopper, and analysis of the nonlinear response of the compliant surface indicates its possible suitability for compliant wall experiments. Periodic structures are found to lock in the desired wavelengths of motion. Laminated structures are found to be very ineffective as compliant models, except when there is no bonding between the membrane and the backing. Computer programs developed for these analyses are documented.

  6. Report of tritide study at the Responsive Neutron Generator Product Deployment Center.

    SciTech Connect

    Burkhart, Robert; Coffey, Jaime

    2008-11-01

    This report documents a study of sample counting results for wipes from routine surface area monitoring conducted at the Responsive Neutron Generator Product Deployment Center (RNGPDC) at Sandia National Laboratories (SNL). The study was initiated in November 2006, with two samples suspected of containing erbium tritide, after some samples were found to exhibit higher tritium counting rates upon recount at a later time. The main goal of the study was to determine whether the current practice of analyzing tritium wipe samples once, within a few days of sample collection, is adequate to accurately quantify the amount of tritium on the sample when tritides may be present. Recommendations are made toward routine recounting of vials suspected of containing particulate forms of tritium.

  7. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE+ cells in memory responses is particularly unclear. IgE B cell differentiation is characterized by a transient GC phase, a bias towards the plasma cell (PC) fate,...

  8. Experimental research activities in dynamic response and sonic fatigue of hypersonic vehicle structures at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Rizzi, Stephen A.

    1993-01-01

    This paper presents an overview of experimental research activities being pursued at the NASA Langley Research Center for dynamic response and sonic fatigue of hypersonic vehicle structures. The capabilities of the principle test facility, the Thermal Acoustic Fatigue Apparatus, are first given. Results from recent dynamic response and sonic fatigue tests on candidate hypersonic vehicle structures are then presented.

  9. Prospective Impact of Responsibility Center Budgeting on Communication and Theatre Programs: View from a State Supported University.

    ERIC Educational Resources Information Center

    Dick, Robert C.

    In response to the nationwide trend toward increased financial pressures and growing demands by state legislatures for accountability, several large universities (including Indiana University) have adopted various forms of "responsibility center budgeting" (RCB), which has fiscal implications for programs in speech communication and related…

  10. Responsiveness of Lebanon's primary healthcare centers to non-communicable diseases and related healthcare needs.

    PubMed

    Yassoub, Rami; Hashimi, Suha; Awada, Siham; El-Jardali, Fadi

    2014-01-01

    Lebanon currently faces a rise in non-communicable diseases (NCD) that is stressing the population's health and financial well-being. Preventive care is recognized as the optimal health equitable, cost-effective solution. The study aims to assess the responsiveness of primary health care centers (PHCs) to NCD, and identify the needed health arrangements and responsibilities of PHCs, the Ministry Of Public Health and other healthcare system entities, for PHCs to purse a more preventive role against NCD. Single and group interviews were conducted via a semi-structured questionnaire with 10 PHCs from Lebanon's primary health care network that have undergone recent pilot accreditation and are recognized for having quality services and facilities. This manifested administrative aspects and NCD-related services of PHCs and generated information regarding the centers' deficiencies, strengths and areas needing improvement for fulfilling a more preventive role. Administrative features of PHCs varied according to number and type of health personnel employed. Variations and deficiencies within and among PHCs were manifested specifically at the level of cardiovascular and respiratory diseases and cancer. PHCs identified the pilot accreditation as beneficial at the administrative and clinical levels; however, various financial and non-financial resources, in addition to establishing a strong referral system with secondary care settings and further arrangements with MOPH, are necessary for PHCs to pursue a stronger preventive role. The generated results denote needed changes within the healthcare system's governance, financing and delivery. They involve empowering PHCs and increasing their breadth of services, allocating a greater portion of national budget to health and preventive care, and equipping PHCs with personnel skilled in conducting community-wide preventive activities. PMID:23729408

  11. Teachers’ Relationship Closeness with Students as a Resource for Teacher Wellbeing: A Response Surface Analytical Approach

    PubMed Central

    Milatz, Anne; Lüftenegger, Marko; Schober, Barbara

    2015-01-01

    Teachers’ relationship quality with students has been argued to be an important source of teacher wellbeing. Thus, the current study aimed to investigate to what extent teachers’ relationship closeness toward students, combined with attachment security is a resource protecting against teacher burnout. Eighty-three elementary school teachers reported on their most and least attached student’s relationship closeness, their attachment security and levels of burnout, as measured by emotional exhaustion, depersonalization and personal accomplishment. Response surface analysis (RSA), enabling researchers to investigate the effect of congruence/incongruence of two predictors on an outcome, revealed that teachers’ depersonalization and emotional exhaustion were lowest when they developed homogenous close relationships toward the students within their classroom and when teachers in general made congruent relationship experiences. No RSA model could be specified for personal accomplishment, even though a correlational analysis revealed that increasing closeness with students fostered teachers’ personal accomplishment. Teachers’ secure attachment experiences were not directly related to burnout, but enhanced their capability to establish close relationships toward their students. Findings suggest that teachers’ relationships toward students are a resource for the teacher’s wellbeing, which highlights once again the importance of student–teacher relationships in education. PMID:26779045

  12. Analytical study of graphite-epoxy tube response to thermal loads

    NASA Technical Reports Server (NTRS)

    Knott, Tamara W.; Hyer, M. W.

    1988-01-01

    The thermally-induced stresses and deformations in graphite-epoxy tubes with aluminum foil bonded to both inner and outer surfaces, and to the outer surface only are computed. Tubes fabricated from three material systems, T300/934, P75s/934, and P75s/BP907, and having a 1 inch inner radius and a lamination sequence of (+15/0 + or - 10/0)sub s are studied. Radial, axial, and circumferential stresses in the various layers of the tube, in the foil, and in the adhesive bonding the foil to the tubes are computed using an elasticity solution. The results indicate that the coatings have no detrimental effect on the stress state in the tube, particularly those stresses that lead to microcracking. The addition of the aluminum foil does, however, significantly influence the axial expansion of the T300/934 tube, the tube with the softer graphite fibers. The addition of foil can change the sign of the axial coefficient of thermal expansion. Twist tendencies of the tubes are only slightly affected by the addition of the coatings, but are of second order compared to the axial response.

  13. Early maternal separation and responsiveness to thermal nociception in rodent offspring: A meta-analytic review.

    PubMed

    Chen, Liyun; Jackson, Todd

    2016-02-15

    Although numerous animal studies have assessed the impact of maternal separation upon pain sensitivity, overall conclusions are difficult to draw about the literature in light of mixed patterns of findings. In this research, a meta-analysis was performed to assess effects of early maternal separation on sensitivity to nociceptive thermal stimulation in rodent offspring and to identify moderators that might explain variable results between studies. Fifteen studies comprising 19 rodent offspring samples (N=1642) fulfilled all selection criteria. Analyses indicated that rodent offspring exposed to early maternal separation had longer response latencies (RLs) reflecting lower sensitivity to nociceptive thermal stimulation compared to non-separated controls. Heightened effect size heterogeneity was also evident. Moderator analyses indicated variable findings between studies were partially or fully explained by operationalizations of maternal separation (early handling vs. maternal separation), type of noxious stimuli, age of testing, receipt of injections during separation, sex composition of samples, and publication year. Biobehavioral underpinnings of overall group differences and moderator effects are posited in the discussion. PMID:26592163

  14. Research on Subjective Response to Simulated Sonic Booms at NASA Langley Research Center

    NASA Technical Reports Server (NTRS)

    Sullivan, Brenda M.

    2005-01-01

    Over the past 15 years, NASA Langley Research Center has conducted many tests investigating subjective response to simulated sonic booms. Most tests have used the Sonic Boom Booth, an airtight concrete booth fitted with loudspeakers that play synthesized sonic booms pre-processed to compensate for the response of the booth/loudspeaker system. Tests using the Booth have included investigations of shaped booms, booms with simulated ground reflections, recorded booms, outdoor and indoor booms, booms with differing loudness for bow and tail shocks, and comparisons of aircraft flyover recordings with sonic booms. Another study used loudspeakers placed inside people s houses, so that they could experience the booms while in their own homes. This study investigated the reactions of people to different numbers of booms heard within a 24-hour period. The most recent Booth test used predicted boom shapes from candidate low-boom aircraft. At present, a test to compare the Booth with boom simulators constructed by Gulfstream Aerospace Corporation and Lockheed Martin Aeronautics Company is underway. The Lockheed simulator is an airtight booth similar to the Langley booth; the Gulfstream booth uses a traveling wave method to create the booms. Comparison of "realism" as well as loudness and other descriptors is to be studied.

  15. Experimental and Analytical Characterization of the Macromechanical Response for Triaxial Braided Composite Materials

    NASA Technical Reports Server (NTRS)

    Littell, Justin D.

    2013-01-01

    micromacromechanical computer model is created to simulate the behavior of these composite material systems under static and ballistic impact loading using the test data acquired. The model also quantifies the way in which the fiber/matrix interface affects material response under static and impact loading. The results show that the test methods are capable of accurately quantifying the polymer resin under a variety of strain rates and temperature for three loading conditions. The resin strength and stiffness data show a clear rate and temperature dependence. The data also show the hydrostatic stress effects and hysteresis, all of which can be used by researchers developing composite constitutive models for the resins. The results for the composite data reveal noticeable differences in strength, failure strain, and stiffness in the different material systems presented. The investigations into the microscale failure mechanisms provide information about the nature of the different material system behaviors. Finally, the developed computer model predicts composite static strength and stiffness to within 10 percent of the gathered test data and also agrees with composite impact data, where available.

  16. Geographic Variation in Tsunami Warning Center Response Time: Identifying Areas of Greatest Concern

    NASA Astrophysics Data System (ADS)

    Becker, N. C.; Sardiña, V.; Cessaro, R. K.; Fryer, G. J.; Weinstein, S.

    2010-12-01

    network. We estimate the time required for P-waves generated by subduction zone earthquakes to reach the number of stations typically needed to produce a tsunami warning. We then project these data to the nearest coastlines to produce a table of P-wave reception times for earthquakes affecting these coastlines. Next, we subtract these reception time values from the travel time of tsunamis from these earthquakes to the coastlines. The resulting data sets and corresponding maps reveal the time window of opportunity for populations to act upon PTWC's warnings and safely evacuate these coastal areas. Our maps show that while most of the world's coastal populations have an hour or more to evacuate after receiving a warning from PTWC, certain coastlines have less than an hour, and in the worst cases, the first tsunami wave will arrive before PTWC can warn the affected areas. While our analysis reveals response problems for a given tsunami warning center, it also highlights the solutions by indicating where to install and monitor additional seismic stations, and where data outages could have the greatest negative impact, thus showing where redundancy in station deployment is most critical.

  17. Opioids depress cortical centers responsible for the volitional control of respiration.

    PubMed

    Pattinson, Kyle T S; Governo, Ricardo J; MacIntosh, Bradley J; Russell, Elizabeth C; Corfield, Douglas R; Tracey, Irene; Wise, Richard G

    2009-06-24

    Respiratory depression limits provision of safe opioid analgesia and is the main cause of death in drug addicts. Although opioids are known to inhibit brainstem respiratory activity, their effects on cortical areas that mediate respiration are less well understood. Here, functional magnetic resonance imaging was used to examine how brainstem and cortical activity related to a short breath hold is modulated by the opioid remifentanil. We hypothesized that remifentanil would differentially depress brain areas that mediate sensory-affective components of respiration over those that mediate volitional motor control. Quantitative measures of cerebral blood flow were used to control for hypercapnia-induced changes in blood oxygen level-dependent (BOLD) signal. Awareness of respiration, reflected by an urge-to-breathe score, was profoundly reduced with remifentanil. Urge to breathe was associated with activity in the bilateral insula, frontal operculum, and secondary somatosensory cortex. Localized remifentanil-induced decreases in breath hold-related activity were observed in the left anterior insula and operculum. We also observed remifentanil-induced decreases in the BOLD response to breath holding in the left dorsolateral prefrontal cortex, anterior cingulate, the cerebellum, and periaqueductal gray, brain areas that mediate task performance. Activity in areas mediating motor control (putamen, motor cortex) and sensory-motor integration (supramarginal gyrus) were unaffected by remifentanil. Breath hold-related activity was observed in the medulla. These findings highlight the importance of higher cortical centers in providing contextual awareness of respiration that leads to appropriate modulation of respiratory control. Opioids have profound effects on the cortical centers that control breathing, which potentiates their actions in the brainstem. PMID:19553457

  18. Improving Response to Foodborne Disease Outbreaks in the United States: Findings of the Foodborne Disease Centers for Outbreak Response Enhancement (FoodCORE), 2010–2012

    PubMed Central

    Biggerstaff, Gwen

    2015-01-01

    Context Each year foodborne diseases (FBD) affect approximately 1 in 6 Americans, resulting in 128,000 hospitalizations and 3,000 deaths. Decreasing resources impact the ability of public health officials to identify, respond to, and control FBD outbreaks. Geographically dispersed outbreaks necessitate multijurisdictional coordination across all levels of the public health system. Rapid response depends on rapid detection. Objective Targeted resources were provided to state and local health departments to improve completeness and timeliness of laboratory, epidemiology, and environmental health (EH) activities for FBD surveillance and outbreak response. Design Foodborne Disease Centers for Outbreak Response Enhancement (FoodCORE) centers, selected through competitive award, implemented work plans designed to make outbreak response more complete and faster in their jurisdiction. Performance metrics were developed and used to evaluate the impact and effectiveness of activities. Participants Departments of Health in Connecticut, New York City, Ohio, South Carolina, Tennessee, Utah, and Wisconsin. Results From the first year (Y1) of the program in October 2010 to the end of second year (Y2) in December 2012, the centers completed molecular subtyping for a higher proportion of Salmonella, Shiga toxin-producing E. coli, and Listeria (SSL) isolates (86% vs 98%) and reduced the average time to complete testing from a median of 8 to 4 days. The centers attempted epidemiologic interviews with more SSL case-patients (93% vs 99%) and the average time to attempt interviews was reduced from a median of 4 to 2 days. During Y2, nearly 200 EH assessments were conducted. FoodCORE centers began documenting model practices such as streamlining and standardizing case-patient interviewing. Conclusion Centers used targeted resources and process evaluation to implement and document practices that improve the completeness and timeliness of FBD surveillance and outbreak response activities

  19. The USGS National Earthquake Information Center's Response to the Wenchuan, China Earthquake

    NASA Astrophysics Data System (ADS)

    Earle, P. S.; Wald, D. J.; Benz, H.; Sipkin, S.; Dewey, J.; Allen, T.; Jaiswal, K.; Buland, R.; Choy, G.; Hayes, G.; Hutko, A.

    2008-12-01

    Immediately after detecting the May 12th, 2008 Mw 7.9 Wenchuan Earthquake, the USGS National Earthquake Information Center (NEIC) began a coordinated effort to understand and communicate the earthquake's seismological characteristics, tectonic context, and humanitarian impact. NEIC's initial estimates of magnitude and location were distributed within 30 minutes of the quake by e-mail and text message to 70,000 users via the Earthquake Notification System. The release of these basic parameters automatically triggered the generation of more sophisticated derivative products that were used by relief and government agencies to plan their humanitarian response to the disaster. Body-wave and centroid moment tensors identified the earthquake's mechanism. Predictive ShakeMaps provided the first estimates of the geographic extent and amplitude of shaking. The initial automated population exposure estimate generated and distributed by the Prompt Assessment of Global Earthquakes for Response (PAGER) system stated that 1.2 million people were exposed to severe-to-extreme shaking (Modified Mercalli Intensity VIII or greater), indicating a large-scale disaster had occurred. NEIC's modeling of the mainshock and aftershocks was continuously refined and expanded. The length and orientation of the fault were determined from aftershocks, finite-fault models, and back-projection source imaging. Firsthand accounts of shaking intensity were collected and mapped by the "Did You Feel It" system. These results were used to refine our ShakeMaps and PAGER exposure estimates providing a more accurate assessment of the extent and enormity of the disaster. The products were organized and distributed in an event-specific summary poster and via the USGS Earthquake Program web pages where they were viewed by millions and reproduced by major media outlets (over 1/2 billion hits were served that month). Rather than just a point showing magnitude and epicenter, several of the media's schematic maps

  20. Evolutionary response of landraces to climate change in centers of crop diversity

    PubMed Central

    Mercer, Kristin L; Perales, Hugo R

    2010-01-01

    Landraces cultivated in centers of crop diversity result from past and contemporary patterns of natural and farmer-mediated evolutionary forces. Successful in situ conservation of crop genetic resources depends on continuity of these evolutionary processes. Climate change is projected to affect agricultural production, yet analyses of impacts on in situ conservation of crop genetic diversity and farmers who conserve it have been absent. How will crop landraces respond to alterations in climate? We review the roles that phenotypic plasticity, evolution, and gene flow might play in sustaining production, although we might expect erosion of genetic diversity if landrace populations or entire races lose productivity. For example, highland maize landraces in southern Mexico do not express the plasticity necessary to sustain productivity under climate change, but may evolve in response to altered conditions. The outcome for any given crop in a given region will depend on the distribution of genetic variation that affects fitness and patterns of climate change. Understanding patterns of neutral and adaptive diversity from the population to the landscape scale is essential to clarify how landraces conserved in situ will continue to evolve and how to minimize genetic erosion of this essential natural resource. PMID:25567941

  1. Evolutionary response of landraces to climate change in centers of crop diversity.

    PubMed

    Mercer, Kristin L; Perales, Hugo R

    2010-09-01

    Landraces cultivated in centers of crop diversity result from past and contemporary patterns of natural and farmer-mediated evolutionary forces. Successful in situ conservation of crop genetic resources depends on continuity of these evolutionary processes. Climate change is projected to affect agricultural production, yet analyses of impacts on in situ conservation of crop genetic diversity and farmers who conserve it have been absent. How will crop landraces respond to alterations in climate? We review the roles that phenotypic plasticity, evolution, and gene flow might play in sustaining production, although we might expect erosion of genetic diversity if landrace populations or entire races lose productivity. For example, highland maize landraces in southern Mexico do not express the plasticity necessary to sustain productivity under climate change, but may evolve in response to altered conditions. The outcome for any given crop in a given region will depend on the distribution of genetic variation that affects fitness and patterns of climate change. Understanding patterns of neutral and adaptive diversity from the population to the landscape scale is essential to clarify how landraces conserved in situ will continue to evolve and how to minimize genetic erosion of this essential natural resource. PMID:25567941

  2. Strategic response by providers to specialty hospitals, ambulatory surgery centers, and retail clinics.

    PubMed

    Burns, Lawton R; David, Guy; Helmchen, Lorens A

    2011-04-01

    Radical innovation and disruptive technologies are frequently heralded as a solution to delivering higher quality, lower cost health care. According to the literature on disruption, local hospitals and physicians (incumbent providers) may be unable to competitively respond to such "creative destruction" and alter their business models for a host of reasons, thus threatening their future survival. However, strategic management theory and research suggest that, under certain conditions, incumbent providers may be able to weather the discontinuities posed by the disrupters. This article analyzes 3 disruptive innovations in service delivery: single-specialty hospitals, ambulatory surgical centers, and retail clinics. We first discuss the features of these innovations to assess how disruptive they are. We then draw on the literature on strategic adaptation to suggest how incumbents develop competitive responses to these disruptive innovations that assure their continued survival. These arguments are then evaluated in a field study of several urban markets based on interviews with both incumbents and entrants. The interviews indicate that entrants have failed to disrupt incumbent providers primarily as a result of strategies pursued by the incumbents. The findings cast doubt on the prospects for these disruptive innovations to transform health care. PMID:21091376

  3. Financial sustainability of academic health centers: identifying challenges and strategic responses.

    PubMed

    Stimpson, Jim P; Li, Tao; Shiyanbola, Oyewale O; Jacobson, Janelle J

    2014-06-01

    Academic health centers (AHCs) play a vital role in the health care system. The training of health care personnel and delivery of health care services, especially to the most complex and financially challenged patients, has been a responsibility increasingly shouldered by AHCs over the years. Additionally, AHCs play a significant role in researching and developing new treatment protocols, including discovering and validating new health technologies. However, AHCs face unique financial challenges in fulfilling their social mission in the health care system. Reforms being implemented under the Affordable Care Act and shifting economic patterns are threatening the financial sustainability of AHCs.The authors review challenges facing AHCs, including training new health care professionals with fewer funding resources, disproportionate clinical care of complex and costly patients, charity care to uninsured and underinsured, and reduced research funding opportunities. Then, they provide a review of some potential solutions to these challenges, including new reimbursement methods, improvements in operational efficiency, price regulation, subsidization of education, improved decision making and communication, utilization of industrial management tools, and increasing internal and external cooperation. Devising solutions to the evolving problems of AHCs is crucial to improving health care delivery in the United States. Most likely, a combination of market, government, and system reforms will be needed to improve the viability of AHCs and assist them in fulfilling their social and organizational missions. PMID:24871234

  4. Immobilization of β-Galactosidase onto Functionalized Graphene Nano-sheets Using Response Surface Methodology and Its Analytical Applications

    PubMed Central

    Kishore, Devesh; Talat, Mahe; Srivastava, Onkar Nath; Kayastha, Arvind M.

    2012-01-01

    Background β-Galactosidase is a vital enzyme with diverse application in molecular biology and industries. It was covalently attached onto functionalized graphene nano-sheets for various analytical applications based on lactose reduction. Methodology/Principal Findings Response surface methodology based on Box-Behnken design of experiment was used for determination of optimal immobilization conditions, which resulted in 84.2% immobilization efficiency. Native and immobilized functionalized graphene was characterized with the help of transmission and scanning electron microscopy, followed by Fourier transform infrared (FTIR) spectroscopy. Functionalized graphene sheets decorated with islands of immobilized enzyme were evidently visualized under both transmission and scanning electron microscopy after immobilization. FTIR spectra provided insight on various chemical interactions and bonding, involved during and after immobilization. Optimum temperature and energy of activation (Ea) remains unchanged whereas optimum pH and Km were changed after immobilization. Increased thermal stability of enzyme was observed after conjugating the enzyme with functionalized graphene. Significance Immobilized β-galactosidase showed excellent reusability with a retention of more than 92% enzymatic activity after 10 reuses and an ideal performance at broad ranges of industrial environment. PMID:22815797

  5. A semi-analytical method to evaluate the dynamic response of functionally graded plates subjected to underwater shock

    NASA Astrophysics Data System (ADS)

    Liang, Xu; Wang, Zhenyu; Wang, Lizhong; Izzuddin, Bassam A.; Liu, Guohua

    2015-02-01

    Functionally graded (FG) plates are of current interest and are widely used in a variety of applications including deep sea exploration and naval/marine and coastal engineering, despite the fact that there has, to date, been little research undertaken on the subject. In order to remedy the situation, an analytical method to investigate the elastic dynamic responses of FG plates to underwater shock is proposed here, their material properties varying by the same exponential law along the thickness direction. Taylor's one dimensional fluid solid interaction (FSI) model is extended to fit a three dimensional model suitable for FG plates. The extended FSI model and Laplace transform are integrated into the state space method, with the transient solution in the time domain being obtained by using the numerical inversion of the Laplace transform. The solutions of the total forces acting throughout the front and back faces in the time domain are derived for the first time. The present method is validated by comparing it with the results of other methods and experiments found in the relevant literature. The influence of the boundary conditions at the backside of the plate and FG parameters on front and back side pressures, cavitations, displacements, stresses and total forces acting throughout the faces are then investigated, with the time progression of the cavitation areas of air-backed plates and water-backed plates being investigated in detail. The method proposed in this paper may prove useful for the future three-dimensional assessment of the response of FG structures when FSI effects are taken into consideration. It is hoped that the results will lead to a full understanding of the mechanism of the interaction between fluid and an FG plate, and that they can be used as benchmark solutions in further research.

  6. Responsibilities and practical limitations in the operation of an astronomical data center

    NASA Technical Reports Server (NTRS)

    Warren, W. H., Jr.; Mead, J. M.; Nagy, T. A.

    1982-01-01

    The operation of an astronomical data center requires that many decisions be made concerning the handling of the astronomical catalogs and data distributed. Should a data center be, as Wilkins (1977) described it, passive, in that catalogs and data are collected and distributed blackbox-wise upon request, or should a data center be active and have experts in various fields to scrutinize, correct, reformat, and document data where necessary. These questions will be addressed and illustrated by describing the current operations and future goals of the Astronomical Data Center at NASA/GSFC.

  7. 20 CFR 670.950 - What are the financial management responsibilities of Job Corps center operators and other...

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 20 Employees' Benefits 3 2011-04-01 2011-04-01 false What are the financial management responsibilities of Job Corps center operators and other service providers? 670.950 Section 670.950 Employees' Benefits EMPLOYMENT AND TRAINING ADMINISTRATION, DEPARTMENT OF LABOR THE JOB CORPS UNDER TITLE I OF THE WORKFORCE INVESTMENT ACT Administrative...

  8. Empirical-Analytical Methodological Research in Environmental Education: Response To a Negative Trend in Methodological and Ideological Discussions.

    ERIC Educational Resources Information Center

    Connell, Sharon

    1997-01-01

    Explores the current status of the empirical-analytical methodology and its "positivist" ideologies in environmental education research through the critical analysis of three criticisms outlined in an article by Robottom and Hart. Suggests that the criticisms misrepresent empirical-analytical methodology in their dismissal of it as behaviorist…

  9. Predictors of pathologic complete response after preoperative concurrent chemoradiotherapy of rectal cancer: a single center experience

    PubMed Central

    Choi, Euncheol; Kim, Jin Hee; Kim, Ok Bae; Kim, Mi Young; Oh, Young Ki; Baek, Sung Gyu

    2016-01-01

    Purpose: To identify possible predictors of pathologic complete response (pCR) of rectal cancer after preoperative concurrent chemoradiotherapy (CCRT). Materials and Methods: We conducted a retrospective review of 53 patients with rectal cancer who underwent preoperative CCRT followed by radical surgery at a single center between January 2007 and December 2012. The median radiotherapy dose to the pelvis was 54.0 Gy (range, 45.0 to 63.0 Gy). Five-fluorouracil-based chemotherapy was administered via continuous infusion with leucovorin. Results: The pCR rate was 20.8%. The downstaging rate was 66%. In univariate analyses, poor and undifferentiated tumors (p = 0.020) and an interval of ≥7 weeks from finishing CCRT to surgery (p = 0.040) were significantly associated with pCR, while female gender (p = 0.070), initial carcinoembryonic antigen concentration of <5.0 ng/dL (p = 0.100), and clinical stage T2 (p = 0.100) were marginally significant factors. In multivariate analysis, an interval of ≥7 weeks from finishing CCRT to surgery (odds ratio, 0.139; 95% confidence interval, 0.022 to 0.877; p = 0.036) was significantly associated with pCR, while stage T2 (odds ratio, 5.363; 95% confidence interval, 0.963 to 29.877; p = 0.055) was a marginally significant risk factor. Conclusion: We suggest that the interval from finishing CCRT to surgery is a predictor of pCR after preoperative CCRT in patients with rectal cancer. Stage T2 cancer may also be an important predictive factor. We hope to perform a robust study by collecting data during treatment to obtain more advanced results. PMID:27306776

  10. Rgs13 Constrains Early B Cell Responses and Limits Germinal Center Sizes

    PubMed Central

    Hwang, Il-Young; Hwang, Kyung-Sun; Park, Chung; Harrison, Kathleen A.; Kehrl, John H.

    2013-01-01

    Germinal centers (GCs) are microanatomic structures that develop in secondary lymphoid organs in response to antigenic stimulation. Within GCs B cells clonally expand and their immunoglobulin genes undergo class switch recombination and somatic hypermutation. Transcriptional profiling has identified a number of genes that are prominently expressed in GC B cells. Among them is Rgs13, which encodes an RGS protein with a dual function. Its canonical function is to accelerate the intrinsic GTPase activity of heterotrimeric G-protein α subunits at the plasma membrane, thereby limiting heterotrimeric G-protein signaling. A unique, non-canonical function of RGS13 occurs following translocation to the nucleus, where it represses CREB transcriptional activity. The functional role of RGS13 in GC B cells is unknown. To create a surrogate marker for Rgs13 expression and a loss of function mutation, we inserted a GFP coding region into the Rgs13 genomic locus. Following immunization GFP expression rapidly increased in activated B cells, persisted in GC B cells, but declined in newly generated memory B and plasma cells. Intravital microscopy of the inguinal lymph node (LN) of immunized mice revealed the rapid appearance of GFP+ cells at LN interfollicular regions and along the T/B cell borders, and eventually within GCs. Analysis of WT, knock-in, and mixed chimeric mice indicated that RGS13 constrains extra-follicular plasma cell generation, GC size, and GC B cell numbers. Analysis of select cell cycle and GC specific genes disclosed an aberrant gene expression profile in the Rgs13 deficient GC B cells. These results indicate that RGS13, likely acting at cell membranes and in nuclei, helps coordinate key decision points during the expansion and differentiation of naive B cells. PMID:23533672

  11. Gift Giving and Receiving in Child-Centered Play Therapy: An Ethical Response

    ERIC Educational Resources Information Center

    Blanco, Pedro J.; Sheely-Moore, Angela I.

    2012-01-01

    Child-centered play therapists are often confronted with the challenge of receiving gifts from clients. This article highlights recommended strategies when faced with gift receiving, exemplified by actual ethical dilemmas encountered by child-centered play therapists. Ethical and therapeutic considerations of therapist gift giving to child clients…

  12. Recommendations for Safe Separation Distances from the Kennedy Space Center (KSC) Vehicle Assembly Building (VAB) Using a Heat-Flux-Based Analytical Approach (Abridged)

    NASA Technical Reports Server (NTRS)

    Cragg, Clinton H.; Bowman, Howard; Wilson, John E.

    2011-01-01

    The NASA Engineering and Safety Center (NESC) was requested to provide computational modeling to support the establishment of a safe separation distance surrounding the Kennedy Space Center (KSC) Vehicle Assembly Building (VAB). The two major objectives of the study were 1) establish a methodology based on thermal flux to determine safe separation distances from the Kennedy Space Center's (KSC's) Vehicle Assembly Building (VAB) with large numbers of solid propellant boosters containing hazard division 1.3 classification propellants, in case of inadvertent ignition; and 2) apply this methodology to the consideration of housing eight 5-segment solid propellant boosters in the VAB. The results of the study are contained in this report.

  13. Analytical Protocol (GC/ECNIMS) for OSWER's Response to OIG Report (2005-P-00022) on Toxaphene Analysis

    EPA Science Inventory

    The research approached the large number and complexity of the analytes as four separate groups: technical toxaphene, toxaphene congeners (eight in number), chlordane, and organochlorine pesticides. This approach was advantageous because it eliminated potential interferences amon...

  14. Protecting worker and public health during responses to catastrophic disasters-learning from the World Trade Center experience.

    PubMed

    Newman, David M

    2014-11-01

    Despite incremental lessons learned since 9/11, responder and community health remain at unnecessary risk during responses to catastrophic disasters, as evidenced during the BP Deepwater Horizon spill and Hurricanes Katrina, Rita, and Sandy. Much of the health harm that occurs during disaster response, as distinct from during the disaster event itself, is avoidable. Protection of public health should be an integral component of disaster response, which should "do no additional harm." This commentary examines how challenges and gaps the World Trade Center response resulted in preventable occupational and environmental health harm. It proposes changes in disaster response policies to better protect the health of rescue and recovery workers, volunteers, and impacted worker and residential communities. PMID:25255981

  15. The Lewis Research Center geomagnetic substorm simulation facility. [its function in determining the response of spacecraft materials

    NASA Technical Reports Server (NTRS)

    Berkopec, F. D.; Stevens, N. J.; Sturman, J. C.

    1976-01-01

    A simulation facility was established at the NASA-Lewis Research Center to determine the response of typical spacecraft materials to the geomagnetic substorm environment and to evaluate instrumentation that will be used to monitor spacecraft system response to this environment. Space environment conditions simulated included the thermal-vacuum conditions of space, solar simulation, geomagnetic substorm electron fluxes and energies, and the low energy plasma environment. Measurements for spacecraft material tests included sample currents, sample surface potentials, and the cumulative number of discharges. Discharge transients were measured by means of current probes and oscilloscopes and were verified by a photomultiplier.

  16. SU-E-P-45: An Analytical Formula for Deriving Mechanical Iso-Center of Rotational Gantry Treatment Unit Rotational Gantry Treatment Unit

    SciTech Connect

    Ding, X; Bues, M

    2015-06-15

    Purpose: To present an analytical formula for deriving mechanical isocenter (MIC) of a rotational gantry treatment unit. The input data to the formula is obtained by a custom-made device. The formula has been implemented and used in an operational proton therapy facility since 2005. Methods: The custom made device consisted of 3 mutually perpendicular dial indicators and 5 clinometers, to obtain displacement data and gantry angle data simultaneously. During measurement, a steel sphere was affixed to the patient couch, and the device was attached to the snout rotating with the gantry. The displacement data and angle data were obtained simultaneously at angular increments of less than 1 degree. The analytical formula took the displacement and angle as input and derived the positions of dial indicator tips (DIT) position in room-fixed coordinate system. The formula derivation presupposes trigonometry and 3-dimentional coordinate transformations. Due to the symmetry properties of the defining equations, the DIT position can be solved for analytically without using mathematical approximations. We define the mean of all points in the DIT trajectory as the MIC. The formula was implemented in computer code, which has been employed during acceptance test, commissioning, as well as routine QA practice in an operational proton facility since 2005. Results: It took one minute for the custom-made device to acquire the measurement data for a full gantry rotation. The DIT trajectory and MIS are instantaneously available after the measurement. The MIC Result agrees well with vendor’s Result, which came from a different measurement setup, as well as different data analysis algorithm. Conclusion: An analytical formula for deriving mechanical isocenter was developed and validated. The formula is considered to be absolutely accurate mathematically. Be analyzing measured data of radial displacements as function of gantry angle, the formula calculates the MI position in room

  17. Characterizing the therapeutic response to deep brain stimulation for treatment-resistant depression: a single center long-term perspective

    PubMed Central

    Crowell, Andrea L.; Garlow, Steven J.; Riva-Posse, Patricio; Mayberg, Helen S.

    2015-01-01

    The number of depressed patients treated with deep brain stimulation (DBS) is relatively small. However, experience with this intervention now spans more than 10 years at some centers, with study subjects typically monitored closely. Here we describe one center’s evolving impressions regarding optimal patient selection for DBS of the subcallosal cingulate (SCC) as well as observations of short- and long-term patterns in antidepressant response and mood reactivity. A consistent time course of therapeutic response with distinct behavioral phases is observed. Early phases are characterized by changes in mood reactivity and a transient and predictable worsening in self ratings prior to stabilization of response. It is hypothesized that this characteristic recovery curve reflects the timeline of neuroplasticity in response to DBS. Further investigation of these emerging predictable psychiatric, biological, and psychosocial patterns will both improve treatment optimization and enhance understanding and recognition of meaningful DBS antidepressant effects. PMID:26124710

  18. The Rural Teacher Center--A Response to Rural Educational Change.

    ERIC Educational Resources Information Center

    Watt, John R.

    The history of the emergence and eventual success of the Mountain Towns' Teacher Center (MTTC) in South Central Vermont is embedded in the socio-historical development of the area and in the process of educational change. In the late 60's and early 70's the skiing industry created an influx of exurban populations which altered the patterns of…

  19. 20 CFR 670.510 - Are Job Corps center operators responsible for providing all vocational training?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... for providing all vocational training? 670.510 Section 670.510 Employees' Benefits EMPLOYMENT AND... providing all vocational training? No, in order to facilitate students' entry into the workforce, the... training programs at specific centers. Contractors providing such vocational training will be selected...

  20. The Hamovitch Research Center: An Experiment in Collective Responsibility for Advancing Science in the Human Services

    ERIC Educational Resources Information Center

    Flynn, Marilyn; Brekke, John S.; Soydan, Haluk

    2008-01-01

    Research centers in schools of social work are growing in number and scope. In this article the authors argue that this increase is in line with the growing recognition that research and science are critical components of the mission of the social work profession. The authors examine the purposes and various models for establishing research…

  1. Math and Science Training in California: The Response of the Teacher Education and Computer Centers.

    ERIC Educational Resources Information Center

    Padia, William L.; Brandes, Barbara G.

    Fifteen Teacher Education and Computer Centers (TEC) were funded by the California State Legislature to provide staff development services to teachers and administrators in all areas of the curriculum, but especially in mathematics, science, technology, and other curriculum areas in which there are significant shortages of teachers. This paper…

  2. Smoking: The Health Consequences of Tobacco Use. An Annotated Bibliography with Analytical Introduction. Science and Social Responsibility Series, No. 2.

    ERIC Educational Resources Information Center

    Schmitz, Cecilia M.; Gray, Richard A.

    This volume contains an extensive introduction to the health consequences of tobacco use and extended annotations of the most important English-language monographs and articles to appear on the subject in the 1980s and 1990s arranged in classified order under select headings. The introductory analytical essay by Richard A. Gray covers: early and…

  3. Empirical-Analytical Methodological Research in Environmental Education: Response to a Negative Trend in Methodological and Ideological Discussions

    ERIC Educational Resources Information Center

    Connell, Sharon

    2006-01-01

    The purpose of this paper is to contribute to methodological discourse about research approaches to environmental education. More specifically, the paper explores the current status of the "empirical-analytical methodology" and its "positivist" (traditional- and post-positivist) ideologies, in environmental education research through the critical…

  4. Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines.

    PubMed

    Wang, Chuan; Hart, Matthew; Chui, Cecilia; Ajuogu, Augustine; Brian, Iona J; de Cassan, Simone C; Borrow, Persephone; Draper, Simon J; Douglas, Alexander D

    2016-08-15

    There is great interest in the development of Ab-inducing subunit vaccines targeting infections, including HIV, malaria, and Ebola. We previously reported that adenovirus vectored vaccines are potent in priming Ab responses, but uncertainty remains regarding the optimal approach for induction of humoral immune responses. In this study, using OVA as a model Ag, we assessed the magnitude of the primary and anamnestic Ag-specific IgG responses of mice to four clinically relevant vaccine formulations: replication-deficient adenovirus; modified vaccinia Ankara (a poxvirus); protein with alum; and protein in the squalene oil-in-water adjuvant Addavax. We then used flow cytometric assays capable of measuring total and Ag-specific germinal center (GC) B cell and follicular Th cell responses to compare the induction of these responses by the different formulations. We report that adenovirus vectored vaccines induce Ag insert-specific GC B cell and Ab responses of a magnitude comparable to those induced by a potent protein/squalene oil-in-water formulation whereas-despite a robust overall GC response-the insert-specific GC B cell and Ab responses induced by modified vaccinia Ankara were extremely weak. Ag-specific follicular Th cell responses to adenovirus vectored vaccines exceeded those induced by other platforms at day 7 after immunization. We found little evidence that innate immune activation by adenovirus may act as an adjuvant in such a manner that the humoral response to a recombinant protein may be enhanced by coadministering with an adenovirus lacking a transgene of interest. Overall, these studies provide further support for the use of replication-deficient adenoviruses to induce humoral responses. PMID:27412417

  5. Meteorological forecasting for emergency preparedness and response at the Kennedy Space Center of Florida

    SciTech Connect

    Lee, R.L.; Albritton, J.R.; Ermak, D.L.; Hodur, R.; Liou, C.S.

    1995-10-13

    The NORAPS model has been used to simulate the motion of Hurricane Erin over Florida. A triplynested grid was used to capture the meteorological features which span from regional to local scales with the highest resolution nest centered at the Kennedy Space Center area. The simulated storm track agreed remarkably well with the observed path of the hurricane. There was also good qualitative agreement between the computed surface precipitation pattern and observations based on radar signatures. Although the validity of the Kuo- type cumulus parameterization scheme used in the model was marginal and even questionable on the finest resolution (4 km) nest, the simulated results were nevertheless qualitatively reasonable. The results generated by NORAPS from the simulation of such a numerical challenging meteorological event were very encouraging. Our next step is to use the meteorological information from the model to provide wind fields for dispersion model simulations of potential atmospheric releases.

  6. Renal Medullary Carcinoma Response to Chemotherapy: a Referral Center Experience in Brazil

    PubMed Central

    Maroja Silvino, Marina Cavalcanti; Venchiarutti Moniz, Camila Motta; Munhoz Piotto, Gustavo Henrique; Siqueira, Sheila; Galapo Kann, Ariel; Dzik, Carlos

    2013-01-01

    Renal medullary carcinoma (RMC) is rare, accounting for less than 1% of all renal neoplasms. Case reports suggest RMC is highly aggressive, poorly responsive to chemotherapy, often metastatic at diagnosis, affects young men with sickle cell trait, and median overall survival (mOS) is less than 12 months. We report the epidemiological characteristics, treatments performed, response rate to each treatment and mOS of five patients with RMC. All patients had sickle cell trait, four were male, three had metastatic disease at diagnosis and mean age at diagnosis was 25 years. Non-metastatic patients were submitted to nephrectomy. Two patients had partial response to first line chemotherapy including cisplatin and gemcitabine. There was no response to sunitinib or second line chemo - therapy; mOS was 6 months. Due to its rarity, case series are the only evidence available to discuss the treatment for RMC. In our experience, only cisplatin and gemcitabine based regimen offered response. PMID:24179656

  7. The Evaluation of Time Performance in the Emergency Response Center to Provide Pre-Hospital Emergency Services in Kermanshah

    PubMed Central

    Mohammadi, Mohsen; Nasiripour Amir, Ashkan; Fakhri, Mahmood; Bakhtiari, Ahad; Azari, Samad; Akbarzadeh, Arash; Goli, Ali; Mahboubi, Mohammad

    2015-01-01

    This study evaluated the time performance in the emergency response center to provide pre-hospital emergency services in Kermanshah. This study was a descriptive retrospective cross-sectional study. In this study 500 cases of patients from Shahrivar (September) 2012 to the end of Shahrivar (September) 2013 were selected and studied by the non-probability quota method. The measuring tool included a preset cases record sheet and sampling method was completing the cases record sheet by referring to the patients’ cases. Data were analyzed using SPSS version 18 and the concepts of descriptive and inferential statistics (Kruskal-Wallis test, benchmark Eta (Eta), Games-Howell post hoc test). The results showed that the interval mean between receiving the mission to reaching the scene, between reaching the scene to moving from the scene, and between moving from the scene to a health center was 7.28, 16.73 and 7.28 minutes. The overall mean of time performance from the scene to the health center was 11.34 minutes. Any intervention in order to speed up service delivery, reduce response times, ambulance equipment and facilities required for accuracy, validity and reliability of the data recorded in the emergency dispatch department, Continuing Education of ambulance staffs, the use of manpower with higher specialize levels such as nurses, supply the job satisfaction, and increase the coordination with other departments that are somehow involved in this process can provide the ground for reducing the loss and disability resulting from traffic accidents. PMID:25560357

  8. The evaluation of time performance in the emergency response center to provide pre-hospital emergency services in Kermanshah.

    PubMed

    Mohammadi, Mohsen; Nasiripour, Amir Ashkan; Fakhri, Mahmood; Bakhtiari, Ahad; Azari, Samad; Akbarzadeh, Arash; Goli, Ali; Mahboubi, Mohammad

    2015-01-01

    This study evaluated the time performance in the emergency response center to provide pre-hospital emergency services in Kermanshah. This study was a descriptive retrospective cross-sectional study. In this study 500 cases of patients from Shahrivar (September) 2012 to the end of Shahrivar (September) 2013 were selected and studied by the non-probability quota method. The measuring tool included a preset cases record sheet and sampling method was completing the cases record sheet by referring to the patients' cases. Data were analyzed using SPSS version 18 and the concepts of descriptive and inferential statistics (Kruskal-Wallis test, benchmark Eta (Eta), Games-Howell post hoc test). The results showed that the interval mean between receiving the mission to reaching the scene, between reaching the scene to moving from the scene, and between moving from the scene to a health center was 7.28, 16.73 and 7.28 minutes. The overall mean of time performance from the scene to the health center was 11.34 minutes. Any intervention in order to speed up service delivery, reduce response times, ambulance equipment and facilities required for accuracy, validity and reliability of the data recorded in the emergency dispatch department, Continuing Education of ambulance staffs, the use of manpower with higher specialize levels such as nurses, supply the job satisfaction, and increase the coordination with other departments that are somehow involved in this process can provide the ground for reducing the loss and disability resulting from traffic accidents. PMID:25560357

  9. Germinal Center B Cell and T Follicular Helper Cell Responses to Viral Vector and Protein-in-Adjuvant Vaccines

    PubMed Central

    Wang, Chuan; Hart, Matthew; Chui, Cecilia; Ajuogu, Augustine; Brian, Iona J.; de Cassan, Simone C.; Borrow, Persephone; Draper, Simon J.

    2016-01-01

    There is great interest in the development of Ab-inducing subunit vaccines targeting infections, including HIV, malaria, and Ebola. We previously reported that adenovirus vectored vaccines are potent in priming Ab responses, but uncertainty remains regarding the optimal approach for induction of humoral immune responses. In this study, using OVA as a model Ag, we assessed the magnitude of the primary and anamnestic Ag–specific IgG responses of mice to four clinically relevant vaccine formulations: replication-deficient adenovirus; modified vaccinia Ankara (a poxvirus); protein with alum; and protein in the squalene oil-in-water adjuvant Addavax. We then used flow cytometric assays capable of measuring total and Ag-specific germinal center (GC) B cell and follicular Th cell responses to compare the induction of these responses by the different formulations. We report that adenovirus vectored vaccines induce Ag insert–specific GC B cell and Ab responses of a magnitude comparable to those induced by a potent protein/squalene oil-in-water formulation whereas—despite a robust overall GC response—the insert-specific GC B cell and Ab responses induced by modified vaccinia Ankara were extremely weak. Ag-specific follicular Th cell responses to adenovirus vectored vaccines exceeded those induced by other platforms at day 7 after immunization. We found little evidence that innate immune activation by adenovirus may act as an adjuvant in such a manner that the humoral response to a recombinant protein may be enhanced by coadministering with an adenovirus lacking a transgene of interest. Overall, these studies provide further support for the use of replication-deficient adenoviruses to induce humoral responses. PMID:27412417

  10. Analytical determination of space station response to crew motion and design of suspension system for microgravity experiments

    NASA Technical Reports Server (NTRS)

    Liu, Frank C.

    1987-01-01

    The objective of this investigation is to make analytical determination of the acceleration produced by crew motion in an orbiting space station and define design parameters for the suspension system of microgravity experiments. A simple structural model for simulation of the IOC space station is proposed. Mathematical formulation of this model provides the engineers a simple and direct tool for designing an effective suspension system.

  11. Analytical determination of space station response to crew motion and design of suspension system for microgravity experiments

    NASA Technical Reports Server (NTRS)

    Liu, F. C.

    1986-01-01

    The objective of this investigation is to make analytical determination of the acceleration produced by crew motion in an orbiting space station and define design parameters for the suspension system of microgravity experiments. A simple structural model for simulation of the IOC space station is proposed. Mathematical formulation of this model provides the engineers a simple and direct tool for designing an effective suspension system.

  12. Evaluating initial spine trauma response: injury time to trauma center in PA, USA.

    PubMed

    Harrop, James S; Ghobrial, George M; Chitale, Rohan; Krespan, Kelly; Odorizzi, Laura; Fried, Tristan; Maltenfort, Mitchell; Cohen, Murray; Vaccaro, Alexander

    2014-10-01

    Historical perceptions regarding the severity of traumatic spinal cord injury has led to considerable disparity in triage to tertiary care centers. This article retrospectively reviews a large regional trauma database to analyze whether the diagnosis of spinal trauma affected patient transfer timing and patterns. The Pennsylvania Trauma database was retrospectively reviewed. All acute trauma patient entries for level I and II centers were categorized for diagnosis, mechanism, and location of injury, analyzing transportation modality and its influence on time of arrival. A total of 1162 trauma patients were identified (1014 blunt injuries, 135 penetrating injuries and 12 other) with a mean transport time of 3.9 hours and a majority of patients arriving within 7 hours (>75%). Spine trauma patients had the longest mean arrival time (5.2 hours) compared to blunt trauma (4.2 hours), cranial neurologic injuries (4.35 hours), and penetrating injuries (2.13 hours, p<0.0001). There was a statistically significant correlation between earlier arrivals and both cranial trauma (p=0.0085) and penetrating trauma (p<0.0001). The fastest modality was a fire rescue (0.93 hours) or police (0.63 hours) vehicle with Philadelphia County (1.1 hour) having the quickest arrival times. Most trauma patients arrived to a specialty center within 7 hours of injury. However subsets analysis revealed that spine trauma patients had the greatest transit times. Present research trials for spinal cord injuries suggest earlier intervention may lead to improved recovery. Therefore, it is important to focus on improvement of the transportation triage system for traumatic spinal patients. PMID:24932590

  13. MORT User's Manual for use with the Management Oversight and Risk Tree analytical logic diagram. [Contains a list of System Safety Development Center publications

    SciTech Connect

    Knox, N.W.; Eicher, R.W.

    1992-02-01

    This report contains the User's Manual for MORT (Management Oversight and Risk Tree), a logic diagram in the form of a work sheet'' that illustrates a long series of interrelated questions. MORT is a comprehensive analytical procedure that provides a disciplined method for determining the causes and contributing factors of major accidents. Alternatively, it serves as a tool to evaluate the quality of an existing system. While similar in many respects to fault tree analysis, MORT is more generalized and presents over 1,500 specific elements of an ideal universal'' management program for optimizing environment, safety and health, and other programs. This User's Manual is intended to be used with the MORT diagram dated February 1992.

  14. Community Environmental Response Facilitation Act (CERFA) report, Fort Holabird Crime Records Center, Baltimore, Maryland

    SciTech Connect

    Not Available

    1994-04-11

    Public Laws designated more than 100 Department of Army facilities for closure and realignment. As a result, it became necessary to expedite the environmental investigation and cleanup process, as necessary, prior to the release and reuse of Army Base Realignment and Closure (BRAC) property. The BRAC environmental restoration program was established in 1989 with the first round (BRAC 88) of base closures and continued with subsequent rounds (BRAC 91, BRAC 93, etc.). As a result of the BRAC program, Fort Holabird Crime Records Center has been investigated to determine its environmental condition.

  15. Human-centered design of a cyber-physical system for advanced response to Ebola (CARE).

    PubMed

    Dimitrov, Velin; Jagtap, Vinayak; Skorinko, Jeanine; Chernova, Sonia; Gennert, Michael; Padir, Taşkin

    2015-08-01

    We describe the process towards the design of a safe, reliable, and intuitive emergency treatment unit to facilitate a higher degree of safety and situational awareness for medical staff, leading to an increased level of patient care during an epidemic outbreak in an unprepared, underdeveloped, or disaster stricken area. We start with a human-centered design process to understand the design challenge of working with Ebola treatment units in Western Africa in the latest Ebola outbreak, and show preliminary work towards cyber-physical technologies applicable to potentially helping during the next outbreak. PMID:26737868

  16. Use of Strain Measurements from Acoustic Bench Tests of the Battleship Flowliner Test Articles To Link Analytical Model Results to In-Service Resonant Response

    NASA Technical Reports Server (NTRS)

    Frady, Greg; Smaolloey, Kurt; LaVerde, Bruce; Bishop, Jim

    2004-01-01

    The paper will discuss practical and analytical findings of a test program conducted to assist engineers in determining which analytical strain fields are most appropriate to describe the crack initiating and crack propagating stresses in thin walled cylindrical hardware that serves as part of the Space Shuttle Main Engine's fuel system. In service the hardware is excited by fluctuating dynamic pressures in a cryogenic fuel that arise from turbulent flow/pump cavitation. A bench test using a simplified system was conducted using acoustic energy in air to excite the test articles. Strain measurements were used to reveal response characteristics of two Flowliner test articles that are assembled as a pair when installed in the engine feed system.

  17. Quo vadis, analytical chemistry?

    PubMed

    Valcárcel, Miguel

    2016-01-01

    This paper presents an open, personal, fresh approach to the future of Analytical Chemistry in the context of the deep changes Science and Technology are anticipated to experience. Its main aim is to challenge young analytical chemists because the future of our scientific discipline is in their hands. A description of not completely accurate overall conceptions of our discipline, both past and present, to be avoided is followed by a flexible, integral definition of Analytical Chemistry and its cornerstones (viz., aims and objectives, quality trade-offs, the third basic analytical reference, the information hierarchy, social responsibility, independent research, transfer of knowledge and technology, interfaces to other scientific-technical disciplines, and well-oriented education). Obsolete paradigms, and more accurate general and specific that can be expected to provide the framework for our discipline in the coming years are described. Finally, the three possible responses of analytical chemists to the proposed changes in our discipline are discussed. PMID:26631024

  18. Forensic Science Center

    SciTech Connect

    Andresen, B.; Grant, P.M.

    1994-03-01

    Since 1991, the Laboratory's Forensic Science Center has focused a comprehensive range of analytical expertise on issues related to non proliferation, counterterrorism, and domestic law enforcement. During this short period, LLNL's singular combination of human and technological resources has made the Center among the best of its kind in the world. The Forensic Science Center houses a variety of state-of-the-art analytical tools ranging from gas chromatograph/mass spectrometers to ultratrace DNA detection techniques. The Center's multidisciplinary staff provides expertise in organic and inorganic analytical chemistry, nuclear science, biochemistry, and genetics useful for supporting law enforcement and for verifying compliance with international treaties and agreements.

  19. Evidence for formation of DNA repair centers and dose-response nonlinearity in human cells

    PubMed Central

    Neumaier, Teresa; Swenson, Joel; Pham, Christopher; Polyzos, Aris; Lo, Alvin T.; Yang, PoAn; Dyball, Jane; Asaithamby, Aroumougame; Chen, David J.; Bissell, Mina J.; Thalhammer, Stefan; Costes, Sylvain V.

    2012-01-01

    The concept of DNA “repair centers” and the meaning of radiation-induced foci (RIF) in human cells have remained controversial. RIFs are characterized by the local recruitment of DNA damage sensing proteins such as p53 binding protein (53BP1). Here, we provide strong evidence for the existence of repair centers. We used live imaging and mathematical fitting of RIF kinetics to show that RIF induction rate increases with increasing radiation dose, whereas the rate at which RIFs disappear decreases. We show that multiple DNA double-strand breaks (DSBs) 1 to 2 μm apart can rapidly cluster into repair centers. Correcting mathematically for the dose dependence of induction/resolution rates, we observe an absolute RIF yield that is surprisingly much smaller at higher doses: 15 RIF/Gy after 2 Gy exposure compared to approximately 64 RIF/Gy after 0.1 Gy. Cumulative RIF counts from time lapse of 53BP1-GFP in human breast cells confirmed these results. The standard model currently in use applies a linear scale, extrapolating cancer risk from high doses to low doses of ionizing radiation. However, our discovery of DSB clustering over such large distances casts considerable doubts on the general assumption that risk to ionizing radiation is proportional to dose, and instead provides a mechanism that could more accurately address risk dose dependency of ionizing radiation. PMID:22184222

  20. Metal-centered polymers: Using controlled polymerization methodologies for the generation of responsive materials

    NASA Astrophysics Data System (ADS)

    Johnson, Robert Matthew

    Controlled polymerization methods were used to prepare highly modular polymeric metal complexes via convergent and divergent strategies. In these materials, the metal center provides a versatile hub for preparing diverse architectures through coordinative bonds. Moreover, the metal complex introduces various properties to the polymer such as luminescence, magnetism, or electroactivity. Suitably functionalized metal complexes have been used for the atom transfer radical polymerization of acrylate and methacrylate monomers by metalloinitiation to generate luminescent biocompatible materials through a divergent synthesis. By cleaving the tert-butyl groups from poly(tert -butyl acrylate), water soluble [Ru(bpyPAA2)3] 2+ has been prepared as well as the amphiphilic star block copolymer [Ru{bpy(PLA-PAA)2}3]2+ (PLA = poly(lactic acid), PAA = poly(acrylic acid) Bipyridine-centered polymeric macroligands may be chelated to a variety of metal salts. The polymer size greatly influences the formation of [Fe(bpy) 3]2+ centered polymers. As the molecular weight increases (> ˜25 kDa) tris complex formation decreases. Tris(bpy) synthesis is also impacted by chemical composition. BpyPtBA2 (PtBA = poly(tert-butyl acrylate) generates an iron mono(bpy) complex before giving rise to the bis(bpy) iron complex; no tris complex is observed. In contrast, the combination of bpyPEG2 (3 equiv) (PEG = (poly(ethylene glycol)) results in the formation of some iron tris(bpy) compound; however, complete tris(bpy) product formation is suppressed, presumably because of the chelating ability of the PEG chains. These examples contrast with other polymeric macroligands such as bpyPS2, bpyPMMA2, bpyPCL2 and bpyPLA 2 (PS = polystyrene; PMMA = poly(methyl methacrylate); PCL = poly(epsilon-caprolactone); PLA = poly(DL-lactic acid)) for which chelation reactions are facile for low molecular weight macroligands (<15 kDa), with chelation efficiencies (defined as (epsilonPMC/epsilonbpy) x 100%) only declining

  1. Vegetation Response to Carbon Dioxide and Climate: Data from the Carbon Dioxide Information Analysis Center (CDIAC)

    DOE Data Explorer

    CDIAC products are indexed and searchable through a customized interface powered by ORNL's Mercury search engine. Products include numeric data packages, publications, trend data, atlases, and models and can be searched for by subject area, keywords, authors, product numbers, time periods, collection sites, spatial references, etc. Some of the collections may also be included in the CDIAC publication Trends Online: A Compendium of Global Change Data. Most data sets, many with numerous data files, are free to download from CDIAC's ftp area. Information related to vegetation response to carbon dioxide and climate includes: • Area and Carbon Content of Sphagnum Since Last Glacial Maximum (2002) (Trends Online) • TDE Model Intercomparison Project Data Archive • Presentations and abstracts from the recent DOE Terrestrial Science Team Meeting (Argonne National Laboratory, October 29-31, 2001) • FACE (Free-Air CO2 Enrichment) • Walker Branch Throughfall Displacement Experiment Data Report: Site Characterization, System Performance, Weather, Species Composition, and Growth (2001) • Bibliography on CO2 Effects on Vegetation and Ecosystems: 1990-1999 Literature (2000) • Direct effects of atmospheric CO2 enrichment on plants and ecosystems: An updated bibliographic data base (1994) • A Database of Herbaceous Vegetation Responses to Elevated Atmospheric CO2 (1999) • A Database of Woody Vegetation Responses to Elevated Atmospheric CO2 (1999) • Forest Responses to Anthropogenic Stress (FORAST) Database (1995) • Effects of CO2 and Nitrogen Fertilization on Growth and Nutrient Content of Juvenile Ponderosa Pine (1998) • Carbon Dioxide Enrichment: Data on the Response of Cotton to Varying CO2Irrigation, and Nitrogen (1992) • Growth and Chemical Responses to CO2 Enrichment Virginia Pine Pinus Virginiana Mill.(1985)

  2. Community-Centered Responses to Ebola in Urban Liberia: The View from Below

    PubMed Central

    Abramowitz, Sharon Alane; McLean, Kristen E.; McKune, Sarah Lindley; Bardosh, Kevin Louis; Fallah, Mosoka; Monger, Josephine; Tehoungue, Kodjo; Omidian, Patricia A.

    2015-01-01

    Background The West African Ebola epidemic has demonstrated that the existing range of medical and epidemiological responses to emerging disease outbreaks is insufficient, especially in post-conflict contexts with exceedingly poor healthcare infrastructures. In this context, community-based responses have proven vital for containing Ebola virus disease (EVD) and shifting the epidemic curve. Despite a surge in interest in local innovations that effectively contained the epidemic, the mechanisms for community-based response remain unclear. This study provides baseline information on community-based epidemic control priorities and identifies innovative local strategies for containing EVD in Liberia. Methodology/Principal Findings This study was conducted in September 2014 in 15 communities in Monrovia and Montserrado County, Liberia – one of the epicenters of the Ebola outbreak. Findings from 15 focus group discussions with 386 community leaders identified strategies being undertaken and recommendations for what a community-based response to Ebola should look like under then-existing conditions. Data were collected on the following topics: prevention, surveillance, care-giving, community-based treatment and support, networks and hotlines, response teams, Ebola treatment units (ETUs) and hospitals, the management of corpses, quarantine and isolation, orphans, memorialization, and the need for community-based training and education. Findings have been presented as community-based strategies and recommendations for (1) prevention, (2) treatment and response, and (3) community sequelae and recovery. Several models for community-based management of the current Ebola outbreak were proposed. Additional findings indicate positive attitudes towards early Ebola survivors, and the need for community-based psychosocial support. Conclusions/Significance Local communities’ strategies and recommendations give insight into how urban Liberian communities contained the EVD outbreak

  3. Experimental and analytical study on the flutter and gust response characteristics of a torsion-free-wing airplane model. [in the Langley transonic dynamics tunnel

    NASA Technical Reports Server (NTRS)

    Murphy, A. C.

    1981-01-01

    Experimental data and correlative analytical results on the flutter and gust response characteristics of a torsion-free-wing (TFW) fighter airplane model are presented. TFW consists of a combined wing/boom/canard surface and was tested with the TFW free to pivot in pitch and with the TFW locked to the fuselage. Flutter and gust response characteristics were measured in the Langley Transonic Dynamics Tunnel with the complete airplane model mounted on a cable mount system that provided a near free flying condition. Although the lowest flutter dynamic pressure was measured for the wing free configuration, it was only about 20 deg less than that for the wing locked configuration. However, no appreciable alleviation of the gust response was measured by freeing the wing.

  4. Effect of Percent Relative Humidity, Moisture Content, and Compression Force on Light-Induced Fluorescence (LIF) Response as a Process Analytical Tool.

    PubMed

    Shah, Ishan G; Stagner, William C

    2016-08-01

    The effect of percent relative humidity (16-84% RH), moisture content (4.2-6.5% w/w MC), and compression force (4.9-44.1 kN CF) on the light-induced fluorescence (LIF) response of 10% w/w active pharmaceutical ingredient (API) compacts is reported. The fluorescent response was evaluated using two separate central composite designs of experiments. The effect of % RH and CF on the LIF signal was highly significant with an adjusted R (2)  = 0.9436 and p < 0.0001. Percent relative humidity (p = 0.0022), CF (p < 0.0001), and % RH(2) (p = 0.0237) were statistically significant factors affecting the LIF response. The effects of MC and CF on LIF response were also statistically significant with a p value <0.0001 and adjusted R (2) value of 0.9874. The LIF response was highly impacted by MC (p < 0.0001), CF (p < 0.0001), and MC(2) (p = 0022). At 10% w/w API, increased % RH, MC, and CF led to a nonlinear decrease in LIF response. The derived quadratic model equations explained more than 94% of the data. Awareness of these effects on LIF response is critical when implementing LIF as a process analytical tool. PMID:27435199

  5. Toddlers' Bids and Teachers' Responses in Title XX Day Care Centers.

    ERIC Educational Resources Information Center

    Honig, Alice S.; Wittmer, Donna S.

    Part of a larger investigation of teacher-child-peer interactions among two- and three-year-old children in day care, this microanalytic study of toddler-initiated bids (attempts to communicate with caregivers) and teacher responses depicts in detail toddler-caregiver interaction. Subjects for the study were 25 males and 25 females between the…

  6. Nonlinear optical response in a zincblende GaN cylindrical quantum dot with donor impurity center

    NASA Astrophysics Data System (ADS)

    Hoyos, Jaime H.; Correa, J. D.; Mora-Ramos, M. E.; Duque, C. A.

    2016-03-01

    We calculate the nonlinear optical absorption coefficient of a cylindrical zincblende GaN-based quantum dot. For this purpose, we consider Coulomb interactions between electrons and an impurity ionized donor atom. The electron-donor-impurity spectrum and the associated quantum states are calculated using the effective mass approximation with a parabolic potential energy model describing both the radial and axial electron confinement. We also include the effects of the hydrostatic pressure and external electrostatic fields. The energy spectrum is obtained through an expansion of the eigenstates as a linear combination of Gaussian-type functions which reduces the computational effort since all the matrix elements are obtained analytically. Therefore, the numerical problem is reduced to the direct diagonalization of the Hamiltonian. The obtained energies are used in the evaluation of the dielectric susceptibility and the nonlinear optical absorption coefficient within a modified two-level approach in a rotating wave approximation. This quantity is investigated as a function of the quantum dot dimensions, the impurity position, the external electric field intensity and the hydrostatic pressure. The results of this research could be important in the design and fabrication of zincblende GaN-quantum-dot-based electro-optical devices.

  7. Corn Response as Affected by Planting Distance from the Center of Strip-Till Fertilized Rows

    PubMed Central

    Adee, Eric; Hansel, Fernando D.; Ruiz Diaz, Dorivar A.; Janssen, Keith

    2016-01-01

    Strip-till has been used at a large scale in east central Kansas as an alternative to earlier planting dates under a no-till system. To determine the effects of planting corn (Zea mays) under previously established strip-tilled fertilized rows, experiments were conducted on an Osage silty clay loam soil in 2006 and 2008 and on a Woodson silt loam soil in 2009, 2010, and 2011 using three different planting distances from the strip-tilled fertilized rows (0, 10, 20, and 38 cm) with a strip-till operation performed between 1 and 73 days before planting. The depth of the strip-till fertilizer application was 13–15 cm below the soil surface. Corn that was planted 10 cm from the fertilized row showed greater early season growth, higher plant population, and grain yield. Planting 20 and 38 cm from the center of the fertilized rows showed none of the benefits that are typically associated with strip-tillage system. Enough time should be allowed between the strip-till operation and planting to reach satisfactory soil conditions (e.g., moist and firm seedbed). Our results suggest that the best location for planting strip-tilled fertilized corn vary depending on soil and climatic conditions as well as the time between fertilizer application with the strip-till operation and planting. With fewer number of days, planting directly on the center of fertilized strip-till resulted in decreased plant population and lower grain yield. However, the greatest yield benefit across different planting conditions was attained when planting within 10 cm of the strip. PMID:27588024

  8. Corn Response as Affected by Planting Distance from the Center of Strip-Till Fertilized Rows.

    PubMed

    Adee, Eric; Hansel, Fernando D; Ruiz Diaz, Dorivar A; Janssen, Keith

    2016-01-01

    Strip-till has been used at a large scale in east central Kansas as an alternative to earlier planting dates under a no-till system. To determine the effects of planting corn (Zea mays) under previously established strip-tilled fertilized rows, experiments were conducted on an Osage silty clay loam soil in 2006 and 2008 and on a Woodson silt loam soil in 2009, 2010, and 2011 using three different planting distances from the strip-tilled fertilized rows (0, 10, 20, and 38 cm) with a strip-till operation performed between 1 and 73 days before planting. The depth of the strip-till fertilizer application was 13-15 cm below the soil surface. Corn that was planted 10 cm from the fertilized row showed greater early season growth, higher plant population, and grain yield. Planting 20 and 38 cm from the center of the fertilized rows showed none of the benefits that are typically associated with strip-tillage system. Enough time should be allowed between the strip-till operation and planting to reach satisfactory soil conditions (e.g., moist and firm seedbed). Our results suggest that the best location for planting strip-tilled fertilized corn vary depending on soil and climatic conditions as well as the time between fertilizer application with the strip-till operation and planting. With fewer number of days, planting directly on the center of fertilized strip-till resulted in decreased plant population and lower grain yield. However, the greatest yield benefit across different planting conditions was attained when planting within 10 cm of the strip. PMID:27588024

  9. Semi-analytical solution for three-dimensional transient response of functionally graded annular plate on a two parameter viscoelastic foundation

    NASA Astrophysics Data System (ADS)

    Liang, Xu; Wang, Zhenyu; Wang, Lizhong; Liu, Guohua

    2014-06-01

    The three-dimensional transient analysis of functionally graded annular plates with arbitrary boundary conditions is carried out in this paper. The material properties of the FGM plate are assumed to vary smoothly in an exponential law along the thickness direction. The plate is assumed to rest on a two parameter viscoelastic foundation. A semi-analytical method, which integrates the state space method (SSM), Laplace transform and its inversion, as well as the one-dimensional differential quadrature method (DQM), is proposed to obtain the transient response of the plate. The state space method is used to obtain the analytical solution in the thickness direction. The differential quadrature method is employed to approximate the solution in the radial direction. The Laplace transform and the numerical inversion are used to obtain the solution in time domain. Numerical results show a good agreement between the response histories obtained by the present method and finite element method. The effects of the boundary conditions at the edges, the material graded index, the Winkler and shearing layer elastic coefficients, and the damping coefficient are studied. Numerical examples show that the peak response decreases as the material graded index, the Winkler and shearing layer elastic coefficients, and the damping coefficient increase. The results obtained in this paper can serve as benchmark data in further research.

  10. A simplified analytical solution for thermal response of a one-dimensional, steady state transpiration cooling system in radiative and convective environment

    NASA Technical Reports Server (NTRS)

    Kubota, H.

    1976-01-01

    A simplified analytical method for calculation of thermal response within a transpiration-cooled porous heat shield material in an intense radiative-convective heating environment is presented. The essential assumptions of the radiative and convective transfer processes in the heat shield matrix are the two-temperature approximation and the specified radiative-convective heatings of the front surface. Sample calculations for porous silica with CO2 injection are presented for some typical parameters of mass injection rate, porosity, and material thickness. The effect of these parameters on the cooling system is discussed.

  11. Solution-based characterization of surface-enhanced Raman response of single scattering centers

    SciTech Connect

    Laurence, T A; Talley, C; Schwartzberg, A; Braun, G; Moskovits, M; Reich, N; Huser, T

    2008-03-06

    We demonstrate the rapid optical characterization of large numbers of individual metal nanoparticles freely diffusing in colloidal solution by confocal laser spectroscopy. We find that hollow gold nanospheres and solid silver nanoparticles linked with a bifunctional ligand, both designed nanostructures, exhibit significantly higher monodispersity in their Rayleigh and Raman scattering response than randomly aggregated gold and silver nanoparticles. We show that measurements of rotational diffusion timescales allow sizing of particles significantly more reliably than can be obtained using translational diffusion timescales.

  12. Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B-cell responses.

    PubMed

    Veninga, Henrike; Borg, Ellen G F; Vreeman, Kyle; Taylor, Philip R; Kalay, Hakan; van Kooyk, Yvette; Kraal, Georg; Martinez-Pomares, Luisa; den Haan, Joke M M

    2015-03-01

    Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169(+) macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for the capture of blood-borne Ag and their close proximity to B cells and T cells in the white pulp. Here we show that Ag targeting to CD169(+) macrophages in mice resulted in strong, isotype-switched, high-affinity Ab production and the preferential induction and long-term persistence of Ag-specific GC B cells and follicular Th cells. In agreement with these observations, CD169(+) macrophages retained intact Ag, induced cognate activation of B cells, and increased expression of costimulatory molecules upon activation. In addition, macrophages were required for the production of cytokines that promote B-cell responses. Our results identify CD169(+) macrophages as promoters of high-affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses. PMID:25487358

  13. Antigen targeting reveals splenic CD169+ macrophages as promoters of germinal center B‐cell responses

    PubMed Central

    Veninga, Henrike; Borg, Ellen G. F.; Vreeman, Kyle; Taylor, Philip R.; Kalay, Hakan; van Kooyk, Yvette; Kraal, Georg; Martinez‐Pomares, Luisa

    2015-01-01

    Ag delivery to specific APCs is an attractive approach in developing strategies for vaccination. CD169+ macrophages in the marginal zone of the spleen represent a suitable target for delivery of Ag because of their strategic location, which is optimal for the capture of blood‐borne Ag and their close proximity to B cells and T cells in the white pulp. Here we show that Ag targeting to CD169+ macrophages in mice resulted in strong, isotype‐switched, high‐affinity Ab production and the preferential induction and long‐term persistence of Ag‐specific GC B cells and follicular Th cells. In agreement with these observations, CD169+ macrophages retained intact Ag, induced cognate activation of B cells, and increased expression of costimulatory molecules upon activation. In addition, macrophages were required for the production of cytokines that promote B‐cell responses. Our results identify CD169+ macrophages as promoters of high‐affinity humoral immune responses and emphasize the value of CD169 as target for Ag delivery to improve vaccine responses. PMID:25487358

  14. A fast 3D semi-analytical model for simulating flaw responses provided by a magnetic flux leakage NDT system inspecting ferromagnetic pipes

    NASA Astrophysics Data System (ADS)

    Trillon, Adrien; Deneuville, François; Prémel, Denis; Djafa, Steve; Pichon, Lionel

    2014-02-01

    This communication presents a semi-analytical model based on BEM formalism for computing MFL flaw responses. MFL 2D configurations have been already simulated in the linear case taking into account the complex shape of the magnetizing circuit surrounding the pipe to be inspected. In this paper, the 3D problem is considered, but, in a first step, in order to be able to solve the non-linear problem, we assume that each ferromagnetic part can be divided in a finite number of polyhedral cells of complex shapes, assuming that the relative magnetic permeability is constant inside each cell. The nonlinear magnetosattic problem may be tackled as a finite number of successive 3D linear problems: the unknowns of the problem being the values of the surface magnetic charge density, in this case, the scalar potential of single layer charge on all the facets of each cell. By assuming that the unknowns are piecewise constant on all the facets of each cell, the kernels derived from integral equations can be analytically evaluated. The implemented semi-analytical model reveals itself to be very effective. Some simulated data are presented for some specific configurations before solving truly NDT MFL configurations.

  15. Patterns of Clinical Response to PSA Elevation in American Indian/Alaska Native Men: A Multi-center Pilot Study

    PubMed Central

    Tilburt, Jon C.; Koller, Kathryn; Tiesinga, James J.; Wilson, Robin T.; Trinh, Anne C.; Hill, Kristin; Hall, Ingrid J.; Smith, Judith Lee; Ekwueme, Donatus U.; Petersen, Wesley O.

    2016-01-01

    Objective To assess clinical treatment patterns and response times among American Indian/Alaska Native men with a newly elevated PSA. Methods We retrospectively identified men ages 50–80 receiving care in one of three tribally-operated clinics in Northern Minnesota, one medical center in Alaska, and who had an incident PSA elevation (≥ 4 ng/ml) in a specified time period. A clinical response was considered timely if it was documented as occurring within 90 days of the incident PSA elevation. Results Among 82 AI/AN men identified from medical records with an incident PSA elevation, 49 (60%) received a timely clinical response, while 18 (22%) had no documented clinical response. Conclusions One in five AI/AN men in our study had no documented clinical action following an incident PSA elevation. Although a pilot study, these findings suggest the need to improve the documentation, notification, and care following an elevated PSA at clinics serving AI/AN men. PMID:24185163

  16. The response of academic medical centers to the 2010 Haiti earthquake: the Mount Sinai School of Medicine experience.

    PubMed

    Ripp, Jonathan A; Bork, Jacqueline; Koncicki, Holly; Asgary, Ramin

    2012-01-01

    On January 12, 2010, Haiti was struck by a 7.0 earthquake which left the country in a state of devastation. In the aftermath, there was an enormous relief effort in which academic medical centers (AMC) played an important role. We offer a retrospective on the AMC response through the Mount Sinai School of Medicine (MSSM) experience. Over the course of the year that followed the Earthquake, MSSM conducted five service trips in conjunction with two well-established groups which have provided service to the Haitian people for over 15 years. MSSM volunteer personnel included nurses, resident and attending physicians, and specialty fellows who provided expertise in critical care, emergency medicine, wound care, infectious diseases and chronic disease management of adults and children. Challenges faced included stressful and potentially hazardous working conditions, provision of care with limited resources and cultural and language barriers. The success of the MSSM response was due largely to the strength of its human resources and the relationship forged with effective relief organizations. These service missions fulfilled the institution's commitment to social responsibility and provided a valuable training opportunity in advocacy. For other AMCs seeking to respond in future emergencies, we suggest early identification of a partner with field experience, recruitment of administrative and faculty support across the institution, significant pre-departure orientation and utilization of volunteers to fundraise and advocate. Through this process, AMCs can play an important role in disaster response. PMID:22232447

  17. Client-Centered Advocacy: Every Occupational Therapy Practitioner's Responsibility to Understand Medical Necessity.

    PubMed

    Stover, Alyson D

    2016-01-01

    Occupational therapy practitioners must advocate for clients in multiple ways. The Occupational Therapy Practice Framework: Domain and Process as well as the Occupational Therapy Code of Ethics lend support to advocacy. Recognizing one's responsibility to provide advocacy for clients is different from knowing how to provide that advocacy. One aspect of health care affected by the Patient Protection and Affordable Care Act (ACA) is the definition and implementation of medical necessity. This article outlines some major concepts around medical necessity, particularly in relation to the passage of the ACA, and outlines guidance on how to advocate effectively to meet both individual and community needs. PMID:27548855

  18. The Pacific Tsunami Warning Center's Response to the Tohoku Earthquake and Tsunami

    NASA Astrophysics Data System (ADS)

    Weinstein, S. A.; Becker, N. C.; Shiro, B.; Koyanagi, K. K.; Sardina, V.; Walsh, D.; Wang, D.; McCreery, C. S.; Fryer, G. J.; Cessaro, R. K.; Hirshorn, B. F.; Hsu, V.

    2011-12-01

    The largest Pacific basin earthquake in 47 years, and also the largest magnitude earthquake since the Sumatra 2004 earthquake, struck off of the east coast of the Tohoku region of Honshu, Japan at 5:46 UTC on 11 March 2011. The Tohoku earthquake (Mw 9.0) generated a massive tsunami with runups of up to 40m along the Tohoku coast. The tsunami waves crossed the Pacific Ocean causing significant damage as far away as Hawaii, California, and Chile, thereby becoming the largest, most destructive tsunami in the Pacific Basin since 1960. Triggers on the seismic stations at Erimo, Hokkaido (ERM) and Matsushiro, Honshu (MAJO), alerted Pacific Tsunami Warning Center (PTWC) scientists 90 seconds after the earthquake began. Four minutes after its origin, and about one minute after the earthquake's rupture ended, PTWC issued an observatory message reporting a preliminary magnitude of 7.5. Eight minutes after origin time, the Japan Meteorological Agency (JMA) issued its first international tsunami message in its capacity as the Northwest Pacific Tsunami Advisory Center. In accordance with international tsunami warning system protocols, PTWC then followed with its first international tsunami warning message using JMA's earthquake parameters, including an Mw of 7.8. Additional Mwp, mantle wave, and W-phase magnitude estimations based on the analysis of later-arriving seismic data at PTWC revealed that the earthquake magnitude reached at least 8.8, and that a destructive tsunami would likely be crossing the Pacific Ocean. The earthquake damaged the nearest coastal sea-level station located 90 km from the epicenter in Ofunato, Japan. The NOAA DART sensor situated 600 km off the coast of Sendai, Japan, at a depth of 5.6 km recorded a tsunami wave amplitude of nearly two meters, making it by far the largest tsunami wave ever recorded by a DART sensor. Thirty minutes later, a coastal sea-level station at Hanasaki, Japan, 600 km from the epicenter, recorded a tsunami wave amplitude of

  19. Attenuated Total Reflectance Fourier Transform Infrared Spectroscopy: An analytical technique to understand therapeutic responses at the molecular level

    PubMed Central

    Kalmodia, Sushma; Parameswaran, Sowmya; Yang, Wenrong; Barrow, Colin J.; Krishnakumar, Subramanian

    2015-01-01

    Rapid monitoring of the response to treatment in cancer patients is essential to predict the outcome of the therapeutic regimen early in the course of the treatment. The conventional methods are laborious, time-consuming, subjective and lack the ability to study different biomolecules and their interactions, simultaneously. Since; mechanisms of cancer and its response to therapy is dependent on molecular interactions and not on single biomolecules, an assay capable of studying molecular interactions as a whole, is preferred. Fourier Transform Infrared (FTIR) spectroscopy has become a popular technique in the field of cancer therapy with an ability to elucidate molecular interactions. The aim of this study, was to explore the utility of the FTIR technique along with multivariate analysis to understand whether the method has the resolution to identify the differences in the mechanism of therapeutic response. Towards achieving the aim, we utilized the mouse xenograft model of retinoblastoma and nanoparticle mediated targeted therapy. The results indicate that the mechanism underlying the response differed between the treated and untreated group which can be elucidated by unique spectral signatures generated by each group. The study establishes the efficiency of non-invasive, label-free and rapid FTIR method in assessing the interactions of nanoparticles with cellular macromolecules towards monitoring the response to cancer therapeutics. PMID:26568521

  20. Virological Response and Antiretroviral Drug Resistance Emerging during Antiretroviral Therapy at Three Treatment Centers in Uganda

    PubMed Central

    Kaleebu, Pontiano; Kirungi, Wilford; Watera, Christine; Asio, Juliet; Lyagoba, Fred; Lutalo, Tom; Kapaata, Anne A.; Nanyonga, Faith; Parry, Chris M.; Magambo, Brian; Nazziwa, Jamirah; Nannyonjo, Maria; Hughes, Peter; Hladik, Wolfgang; Ruberantwari, Anthony; Namuwenge, Norah; Musinguzi, Joshua; Downing, Robert; Katongole-Mbidde, Edward

    2015-01-01

    Background With the scale-up of antiretroviral therapy (ART), monitoring programme performance is needed to maximize ART efficacy and limit HIV drug resistance (HIVDR). Methods We implemented a WHO HIVDR prospective survey protocol at three treatment centers between 2012 and 2013. Data were abstracted from patient records at ART start (T1) and after 12 months (T2). Genotyping was performed in the HIV pol region at the two time points. Results Of the 425 patients enrolled, at T2, 20 (4.7%) had died, 66 (15.5%) were lost to follow-up, 313 (73.6%) were still on first-line, 8 (1.9%) had switched to second-line, 17 (4.0%) had transferred out and 1 (0.2%) had stopped treatment. At T2, 272 out of 321 on first and second line (84.7%) suppressed below 1000 copies/ml and the HIV DR prevention rate was 70.1%, just within the WHO threshold of ≥70%. The proportion of participants with potential HIVDR was 20.9%, which is higher than the 18.8% based on pooled analyses from African studies. Of the 35 patients with mutations at T2, 80% had M184V/I, 65.7% Y181C, and 48.6% (54.8% excluding those not on Tenofovir) had K65R mutations. 22.9% had Thymidine Analogue Mutations (TAMs). Factors significantly associated with HIVDR prevention at T2 were: baseline viral load (VL) <100,000 copies/ml [Adjusted odds ratio (AOR) 3.13, 95% confidence interval (CI): 1.36–7.19] and facility. Independent baseline predictors for HIVDR mutations at T2 were: CD4 count <250 cells/μl (AOR 2.80, 95% CI: 1.08–7.29) and viral load ≥100,000 copies/ml (AOR 2.48, 95% CI: 1.00–6.14). Conclusion Strengthening defaulter tracing, intensified follow-up for patients with low CD4 counts and/or high VL at ART initiation together with early treatment initiation above 250 CD4 cells/ul and adequate patient counselling would improve ART efficacy and HIVDR prevention. The high rate of K65R and TAMs could compromise second line regimens including NRTIs. PMID:26700639

  1. Medical Relief Response by Miyako Public Health Center after the Great East Japan Earthquake and Tsunami, 2011.

    PubMed

    Yanagihara, Hiroki

    2016-01-01

    Objectives To improve disaster preparedness, we investigated the response of medical relief activities managed by Iwate Prefectural Miyako Public Health Center during the post-acute phase of the Great East Japan Earthquake and Tsunami on March 11, 2011.Methods The study divided the post-disaster period into three approximate time segments: Period I (time of disaster through late March), Period II (mid-April), and Period III (end of May in Miyako City, early July in Yamada Town). We reviewed records on medical relief activities conducted by medical assistance teams (MATs) in Miyako City and Yamada Town.Results Miyako Public Health Center had organized a meeting to coordinate medical relief activities from Period I to Period III. According to demand for medical services and recovery from the local medical institutions (LMIs) in the affected area, MATs were deployed and active on evacuation centers in each area assigned. The number of patients examined by MATs in Miyako rose to approximately 250 people per day in Period I and decreased to 100 in Period III. However, in Yamada, the number surged to 700 in Period I, fell to 100 in Period II, and decreased to 50 in Period III. This difference could be partly explained as follows. In Miyako, most evacuees had consulted LMIs which restarted medical services after disaster, and the number of LMIs restarted had already reached 29 (94% of the whole) in Period I. In Yamada, most evacuees who had consulted MATs in Period I had almost moved to LMIs restarted in Period II. During the same time, a division of roles and coordination on medical services provision was conducted, such as MATs mainly in charge of primary emergency triage, in response to the number of LMIs restarted which reached 1 (20%) in Period I and 3 (60%) in Period II. Following Period III, more than 80% of patients in Miyako had been a slight illness, such as need for health guidance, and the number of people who underwent emergency medical transport

  2. Assessment of Symptoms in Adult Survivors of Incest: A Factor Analytic Study of the Responses to Childhood Incest Questionnaire.

    ERIC Educational Resources Information Center

    Edwards, Patrick W.; Donaldson, Mary Ann

    1989-01-01

    A study of the construction and factor validity of the Response to Child Incest Questionnaire, a self-report instrument for assessing commonly reported symptoms of adult survivors of incest, is reported. The instrument's usefulness as a pre- and post-treatment measure and further research needs are discussed. (MSE)

  3. Cardiovascular Safety Assessment in Early-Phase Clinical Studies: A Meta-Analytical Comparison of Exposure-Response Models.

    PubMed

    Conrado, D J; Chen, D; Denney, W S

    2016-06-01

    Exposure-response analysis of QT interval in clinical studies has been proposed as a thorough QT study alternative. Many exposure-response model structures have been proposed for cardiovascular (CV) safety markers, but few studies have compared models across multiple drugs. To recommend preferred drug-effect exposure-response models on vital signs and electrocardiogram (ECG) intervals, an individual-level model-based meta-analysis (39 studies and 1,291 subjects) compared 90 model structures. Models were selected to describe the data and cross-validate studies on the same drug. The most commonly selected baseline model was an unstructured model (estimation of a value at each study nominal time) for all measures but blood pressure. The unstructured model estimated a better cross-validated drug-effect when considering all markers. A linear model was the most commonly selected to characterize drug-effect on all markers. We propose these models as a starting point assisting with CV safety exposure-response assessment in nondedicated small studies with healthy subjects. PMID:27318037

  4. A simulation-based and analytic analysis of the off-Hugoniot response of alternative inertial confinement fusion ablator materials

    NASA Astrophysics Data System (ADS)

    Moore, Alastair S.; Prisbrey, Shon; Baker, Kevin L.; Celliers, Peter M.; Fry, Jonathan; Dittrich, Thomas R.; Wu, Kuang-Jen J.; Kervin, Margaret L.; Schoff, Michael E.; Farrell, Mike; Nikroo, Abbas; Hurricane, Omar A.

    2016-09-01

    The attainment of self-propagating fusion burn in an inertial confinement target at the National Ignition Facility will require the use of an ablator with high rocket-efficiency and ablation pressure. The ablation material used during the National Ignition Campaign (Lindl et al. 2014) [1], a glow-discharge polymer (GDP), does not couple as efficiently as simulations indicated to the multiple-shock inducing radiation drive environment created by laser power profile (Robey et al., 2012). We investigate the performance of two other ablators, boron carbide (B4C) and high-density carbon (HDC) compared to the performance of GDP under the same hohlraum conditions. Ablation performance is determined through measurement of the shock speed produced in planar samples of the ablator material subjected to the identical multiple-shock inducing radiation drive environments that are similar to a generic three-shock ignition drive. Simulations are in better agreement with the off-Hugoniot performance of B4C than either HDC or GDP, and analytic estimations of the ablation pressure indicate that while the pressure produced by B4C and GDP is similar when the ablator is allowed to release, the pressure reached by B4C seems to exceed that of HDC when backed by a Au/quartz layer.

  5. Fast, continuous recirculation of germinal center B cell populations enhances robustness of immune response towards varying pathogens

    NASA Astrophysics Data System (ADS)

    Or-Guil, Michal

    2009-03-01

    Germinal centers (GCs) are dynamic microstructures that form in lymphatic tissues during immune responses. There, B cells undergo rapid proliferation and mutation of their B cell receptors (BCRs). Selection of B cells bearing BCRs that bind to the pathogen causing the immune response ultimately leads to BCRs that, when secreted as antibodies, form a new, effective, and pathogen specific antibody repertoire. However, the details of this evolutionary process are poorly understood, since currently available experimental techniques do not allow for direct observation of the prevailing mechanisms [Or-Guil et al., Imm.Rev. 2007]. Based on optimality considerations, we put forward the assumption that GCs are not isolated entities where evolutionary processes occur independently, but interconnected structures which allow for continuous exchange of B cells. We show that this architecture leads to a system whose response is much more robust towards different antigen variants than a set of independently working GCs could ever be. We test this hypothesis by generating our own experimental data (time course of 3-D volume distribution of GCs, analysis of high-throughput BCR sequences), and show that available data is consistent with the outlined hypothesis.

  6. Implications of the World Trade Center Health Program (WTCHP) for the Public Health Response to the Great East Japan Earthquake

    PubMed Central

    CRANE, Michael A.; CHO, Hyunje G.; LANDRIGAN, Phillip J.

    2013-01-01

    The attacks on the World Trade Center (WTC) on September 11, 2001 resulted in a serious burden of physical and mental illness for the 50,000 rescue workers that responded to 9/11 as well as the 400,000 residents and workers in the surrounding areas of New York City. The Zadroga Act of 2010 established the WTC Health Program (WTCHP) to provide monitoring and treatment of WTC exposure-related conditions and health surveillance for the responder and survivor populations. Several reports have highlighted the applicability of insights gained from the WTCHP to the public health response to the Great East Japan Earthquake. Optimal exposure monitoring processes and attention to the welfare of vulnerable exposed sub-groups are critical aspects of the response to both incidents. The ongoing mental health care concerns of 9/11 patients accentuate the need for accessible and appropriately skilled mental health care in Fukushima. Active efforts to demonstrate transparency and to promote community involvement in the public health response will be highly important in establishing successful long-term monitoring and treatment programs for the exposed populations in Fukushima. PMID:24317449

  7. The distinctive germinal center phase of IgE+ B lymphocytes limits their contribution to the classical memory response

    PubMed Central

    He, Jin-Shu; Meyer-Hermann, Michael; Xiangying, Deng; Zuan, Lim Yok; Jones, Leigh Ann; Ramakrishna, Lakshmi; de Vries, Victor C.; Dolpady, Jayashree; Aina, Hoi; Joseph, Sabrina; Narayanan, Sriram; Subramaniam, Sharrada; Puthia, Manoj; Wong, Glenn; Xiong, Huizhong; Poidinger, Michael; Urban, Joseph F.; Lafaille, Juan J.

    2013-01-01

    The mechanisms involved in the maintenance of memory IgE responses are poorly understood, and the role played by germinal center (GC) IgE+ cells in memory responses is particularly unclear. IgE+ B cell differentiation is characterized by a transient GC phase, a bias toward the plasma cell (PC) fate, and dependence on sequential switching for the production of high-affinity IgE. We show here that IgE+ GC B cells are unfit to undergo the conventional GC differentiation program due to impaired B cell receptor function and increased apoptosis. IgE+ GC cells fail to populate the GC light zone and are unable to contribute to the memory and long-lived PC compartments. Furthermore, we demonstrate that direct and sequential switching are linked to distinct B cell differentiation fates: direct switching generates IgE+ GC cells, whereas sequential switching gives rise to IgE+ PCs. We propose a comprehensive model for the generation and memory of IgE responses. PMID:24218137

  8. Emergency preparedness training and response among community health centers and local health departments: results from a multi-state survey.

    PubMed

    Ablah, Elizabeth; Konda, Kelly S; Konda, Kurt; Melbourne, Mollie; Ingoglia, Julie Nelson; Gebbie, Kristine M

    2010-06-01

    Due to their access to medically underserved and vulnerable populations, community health centers (CHCs) can play an essential role in emergency response. CHCs often fill this role in partnership with other local health resources, such as local health departments (LHD). Little research has been done to understand the success of these partnerships as it relates to emergency planning and emergency response. This study compares CHC and LHD personnel regarding past, present, and future collaborative preparedness and response activities. Surveys were distributed electronically to 1,265 clinical and clerical staff at LHDs and CHCs in 23 states who met the study criteria. Of the 522 respondents, 287 (55%) reported having engaged in collaborative preparedness activities in general, with CHCs more likely to report partnering than LHDs. LHDs were more likely than CHCs to report taking part in specific preparedness activities, such as planning activities (91, 79%), (chi(2)(1, N = 280) = 7.395, P < 0.05), mass dispensing drill/exercises (65, 42%), (chi(2)(1, N = 279) = 14.019, P < 0.001), and communication drill/exercises (69, 47%), (chi(2)(1, N = 280) = 13.059, P < 0.001). This study suggests that collaborations between CHCs and LHDs in general are occurring, but these general collaboration are not being translated into participation in functional drills or exercises. Additional efforts to ensure a more comprehensive partnership between CHCs and LHDs in emergency preparedness are warranted. PMID:20379843

  9. Implications of the World Trade Center Health Program (WTCHP) for the public health response to the Great East Japan Earthquake.

    PubMed

    Crane, Michael A; Cho, Hyunje G; Landrigan, Phillip J

    2014-01-01

    The attacks on the World Trade Center (WTC) on September 11, 2001 resulted in a serious burden of physical and mental illness for the 50,000 rescue workers that responded to 9/11 as well as the 400,000 residents and workers in the surrounding areas of New York City. The Zadroga Act of 2010 established the WTC Health Program (WTCHP) to provide monitoring and treatment of WTC exposure-related conditions and health surveillance for the responder and survivor populations. Several reports have highlighted the applicability of insights gained from the WTCHP to the public health response to the Great East Japan Earthquake. Optimal exposure monitoring processes and attention to the welfare of vulnerable exposed sub-groups are critical aspects of the response to both incidents. The ongoing mental health care concerns of 9/11 patients accentuate the need for accessible and appropriately skilled mental health care in Fukushima. Active efforts to demonstrate transparency and to promote community involvement in the public health response will be highly important in establishing successful long-term monitoring and treatment programs for the exposed populations in Fukushima. PMID:24317449

  10. The department of internal medicine: hub of the academic health center response to the aging imperative.

    PubMed

    Hazzard, W R

    2000-08-15

    In the 21st century, geriatrics will increasingly dominate U.S. health care as the median age of the population progressively increases. Academic departments of geriatrics have been created in nations that have already experienced this shift. As an alternative strategy that builds on traditional strengths of academic medicine in the United States, departments of internal medicine should lead a multidepartmental, pan-institutional response to the aging imperative. Recognition of gerontology and geriatric medicine as central to the missions of internal medicine in clinical care, education, and research must be increased. In the process, academic departments of internal medicine will develop a high level of geriatric expertise and will launch many programs that address this challenge. Successful development of geriatric programs will serve as a catalyst to strengthen the integration among and between generalists and subspecialists. This will entail developing optimal sites and systems of geriatric care--at different levels of care and over time--that can enhance the geriatric education of medical students, residents, fellows, and practicing physicians. The study of aging and geriatric health care will also become an integral part of departmental research, in its subspecialty divisions as well as its divisions of general internal medicine and geriatrics. This strategy is urgently recommended as both a challenge and an opportunity for all departments of internal medicine. PMID:10929171

  11. Energy Frontier Research Centers (EFRCs): A Response to Five Challenges for Science and the Imagination (2011 EFRC Summit, panel session)

    SciTech Connect

    Alivisatos, Paul; Crabtree, George; Dresselhaus, Mildred; Ratner, Mark

    2011-05-25

    A distinguished panel of speakers at the 2011 EFRC Summit looks at the EFRC Program and how it serves as a response to "Five Challenges for Science and the Imagination”, the culminating report that arose from a series of Basic Research Needs workshops. The panel members are Paul Alivisatos, the Director of Lawrence Berkeley National Laboratory, George Crabtree, Distinguished Fellow at Argonne National Laboratory, Mildred Dresselhause, Institute Professor at the Massachusetts Institute of Technology, and Mark Ratner, Professor at Northwestern University. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several “grand challenges” and use-inspired “basic research needs” recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  12. Energy Frontier Research Centers (EFRCs): A Response to Five Challenges for Science and the Imagination (2011 EFRC Summit, panel session)

    ScienceCinema

    Alivisatos, Paul (Director, LBNL); Crabtree, George (ANL); Dresselhaus, Mildred (MIT); Ratner, Mark (Northwestern University)

    2012-03-14

    A distinguished panel of speakers at the 2011 EFRC Summit looks at the EFRC Program and how it serves as a response to "Five Challenges for Science and the Imagination?, the culminating report that arose from a series of Basic Research Needs workshops. The panel members are Paul Alivisatos, the Director of Lawrence Berkeley National Laboratory, George Crabtree, Distinguished Fellow at Argonne National Laboratory, Mildred Dresselhause, Institute Professor at the Massachusetts Institute of Technology, and Mark Ratner, Professor at Northwestern University. The 2011 EFRC Summit and Forum brought together the EFRC community and science and policy leaders from universities, national laboratories, industry and government to discuss "Science for our Nation's Energy Future." In August 2009, the Office of Science established 46 Energy Frontier Research Centers. The EFRCs are collaborative research efforts intended to accelerate high-risk, high-reward fundamental research, the scientific basis for transformative energy technologies of the future. These Centers involve universities, national laboratories, nonprofit organizations, and for-profit firms, singly or in partnerships, selected by scientific peer review. They are funded at $2 to $5 million per year for a total planned DOE commitment of $777 million over the initial five-year award period, pending Congressional appropriations. These integrated, multi-investigator Centers are conducting fundamental research focusing on one or more of several ?grand challenges? and use-inspired ?basic research needs? recently identified in major strategic planning efforts by the scientific community. The purpose of the EFRCs is to integrate the talents and expertise of leading scientists in a setting designed to accelerate research that transforms the future of energy and the environment.

  13. Analytical investigations of seismic responses for reinforced concrete bridge columns subjected to strong near-fault ground motion

    NASA Astrophysics Data System (ADS)

    Su, Chin-Kuo; Sung, Yu-Chi; Chang, Shuenn-Yih; Huang, Chao-Hsun

    2007-09-01

    Strong near-fault ground motion, usually caused by the fault-rupture and characterized by a pulse-like velocity-wave form, often causes dramatic instantaneous seismic energy (Jadhav and Jangid 2006). Some reinforced concrete (RC) bridge columns, even those built according to ductile design principles, were damaged in the 1999 Chi-Chi earthquake. Thus, it is very important to evaluate the seismic response of a RC bridge column to improve its seismic design and prevent future damage. Nonlinear time history analysis using step-by-step integration is capable of tracing the dynamic response of a structure during the entire vibration period and is able to accommodate the pulsing wave form. However, the accuracy of the numerical results is very sensitive to the modeling of the nonlinear load-deformation relationship of the structural member. FEMA 273 and ATC-40 provide the modeling parameters for structural nonlinear analyses of RC beams and RC columns. They use three parameters to define the plastic rotation angles and a residual strength ratio to describe the nonlinear load-deformation relationship of an RC member. Structural nonlinear analyses are performed based on these parameters. This method provides a convenient way to obtain the nonlinear seismic responses of RC structures. However, the accuracy of the numerical solutions might be further improved. For this purpose, results from a previous study on modeling of the static pushover analyses for RC bridge columns (Sung et al. 2005) is adopted for the nonlinear time history analysis presented herein to evaluate the structural responses excited by a near-fault ground motion. To ensure the reliability of this approach, the numerical results were compared to experimental results. The results confirm that the proposed approach is valid.

  14. Comparison of different experimental and analytical measures of the thermal annealing response of neutron-irradiated RPV steels

    SciTech Connect

    Iskander, S.K.; Sokolov, M.A.; Nanstad, R.K.

    1997-05-01

    The thermal annealing response of several materials as indicated by Charpy transition temperature (TT) and upper-shelf energy (USE), crack initiation toughness, K{sub Jc}, predictive models, and automated-ball indentation (ABI) testing are compared. The materials investigated are representative reactor pressure vessel (RPV) steels (several welds and a plate) that were irradiated for other tasks of the Heavy-Section Steel Irradiation (HSSI) Program and are relatively well characterized in the unirradiated and irradiated conditions. They have been annealed at two temperatures, 343 and 454 C (650 and 850 F) for varying lengths of time. The correlation of the Charpy response and the fracture toughness, ABI, and the response predicted by the annealing model of Eason et al. for these conditions and materials appears to be reasonable. The USE after annealing at the temperature of 454 C appears to recover at a faster rate than the TT, and even over-recovers (i.e., the recovered USE exceeds that of the unirradiated material).

  15. Analytical testing

    NASA Technical Reports Server (NTRS)

    Flannelly, W. G.; Fabunmi, J. A.; Nagy, E. J.

    1981-01-01

    Analytical methods for combining flight acceleration and strain data with shake test mobility data to predict the effects of structural changes on flight vibrations and strains are presented. This integration of structural dynamic analysis with flight performance is referred to as analytical testing. The objective of this methodology is to analytically estimate the results of flight testing contemplated structural changes with minimum flying and change trials. The category of changes to the aircraft includes mass, stiffness, absorbers, isolators, and active suppressors. Examples of applying the analytical testing methodology using flight test and shake test data measured on an AH-1G helicopter are included. The techniques and procedures for vibration testing and modal analysis are also described.

  16. 20 CFR 670.550 - What responsibilities do Job Corps centers have in assisting students with child care needs?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... child care for their dependent children. (b) Job Corps centers may operate on center child development... have in assisting students with child care needs? 670.550 Section 670.550 Employees' Benefits... Corps centers have in assisting students with child care needs? (a) Job Corps centers are...

  17. 20 CFR 670.550 - What responsibilities do Job Corps centers have in assisting students with child care needs?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... child care for their dependent children. (b) Job Corps centers may operate on center child development... have in assisting students with child care needs? 670.550 Section 670.550 Employees' Benefits... Corps centers have in assisting students with child care needs? (a) Job Corps centers are...

  18. 20 CFR 670.550 - What responsibilities do Job Corps centers have in assisting students with child care needs?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... child care for their dependent children. (b) Job Corps centers may operate on center child development... have in assisting students with child care needs? 670.550 Section 670.550 Employees' Benefits... Corps centers have in assisting students with child care needs? (a) Job Corps centers are...

  19. Endocrine and metabolic response to trauma in hypovolemic patients treated at a trauma center in Brazil

    PubMed Central

    Bahten, Luiz CV; Mauro, Fernando HO; Domingos, Maria F; Scheffer, Paula H; Pagnoncelli, Bruno H; Wille, Marco AR

    2008-01-01

    Background The metabolic changes in trauma patients with shock contribute directly to the survival of the patient. To understand these changes better, we made a rigorous analysis of the variations in the main examinations requested for seriously polytraumatized patients. Methods Prospective analysis of patients with blunt or penetrating trauma with hypovolemic shock, with systolic arterial pressure (SAP) equal to or lower than 90 mmHg at any time during initial treatment in the emergency room and aged between 14 and 60 years old. The following exams were analyzed: sodium, potassium, blood test, glycemia and arterial gasometry. The tests were carried out at intervals: T0 (the first exam, collected on admission) and followed by T24 (24 hours after admission), T48 (48 hours after admission), T72 (72 hours after admission). Results The test evaluations showed that there was a tendency towards hyperglycemia, which was more evident upon admission to hospital. The sodium in all the patients was found to be normal upon admission, with a later decline. However, no patient had significant hyponatremia; there was no significant variation in the potassium variable; the gasometry, low pH, BE (base excess) and bicarbonate levels when the first sample was collected and increased later with PO2 and PCO2 showing only slight variations, which meant an acidotic state during the hemorrhagic shock followed by a response from the organism to reestablish the equilibrium, retaining bicarbonate. The red blood count, shown by the GB (globular volume) and HB (hemoglobin) was normal upon entry but later it dropped steadily until it fell below normal; the white blood count (leukocytes, neutrophils and band neutrophil) remained high from the first moment of evaluation. Conclusion In this study we demonstrated the main alterations that took place in patients with serious trauma, emphasizing that even commonly requested laboratory tests can help to estimate metabolic alterations. Suitable

  20. The true cost of renewables: An analytic response to the coal industry`s attack on renewable energy

    SciTech Connect

    Swezey, B G; Wan, Yih-huei

    1995-10-01

    In April 1995, the Center for Energy and Economic Development (CEED), an umbrella organization of pro-coal interests, released a report entitled Energy Choices in a Competitive Era: The Role of Renewable and Traditional Energy Resources in America`s Electric Generation Mix. The report purports to show that a very modest growth in the use of renewable energy in the U.S. power sector would entail unaffordable costs for the nation`s electricity ratepayers. The National Renewable Energy Laboratory (NREL) was commissioned by the U.S. Department of Energy (DOE) to review the assumptions contained in the report, which was prepared for CEED by Resource Data International, Inc. (RDI). The NREL analysis finds that the conclusions of the CEED/RDI study are based on faulty data and assumptions regarding the comparative economics of coal and renewable energy development. After correcting these errors, NREL finds that a modest growth path of renewable resource development would essentially cost the nation little more than projected electricity market costs for coal-fired generation, even before considering the environmental benefits that would accompany this development.

  1. Pulmonary infection with influenza A virus induces site-specific germinal center and T follicular helper cell responses.

    PubMed

    Boyden, Alexander W; Legge, Kevin L; Waldschmidt, Thomas J

    2012-01-01

    Protection from influenza A virus (IAV) challenge requires switched, high affinity Abs derived from long-lived memory B cells and plasma cells. These B cell subsets are generated in germinal centers (GCs), hallmark structures of T helper cell-driven B cell immunity. A full understanding of the GC reaction after respiratory IAV infection is lacking, as is the characterization of T follicular helper (T(FH)) cells that support GCs. Here, GC B cell and T(FH) cell responses were studied in mice following pulmonary challenge with IAV. Marked GC reactions were induced in draining lymph nodes (dLNs), lung, spleen and nasal-associated lymphoid tissue (NALT), although the magnitude and kinetics of the response was site-specific. Examination of switching within GCs demonstrated IgG2(+) cells to compose the largest fraction in dLNs, lung and spleen. IgA(+) GC B cells were infrequent in these sites, but composed a significant subset of the switched GC population in NALT. Further experiments demonstrated splenectomized mice to withstand a lethal recall challenge, suggesting the spleen to be unnecessary for long-term protection in spite of strong GC responses in this organ. Final studies showed that T(FH) cell numbers were highest in dLNs and spleen, and peaked in all sites prior to the height of the GC reaction. T(FH) cells purified from dLNs generated IL-21 and IFNγ upon activation, although CD4(+)CXCR5(-) T effector cells produced higher levels of all cytokines. Collectively, these findings reveal respiratory IAV infection to induce strong T helper cell-driven B cell responses in various organs, with each site displaying unique attributes. PMID:22792401

  2. A fast, angle-dependent, analytical model of CsI detector response for optimization of 3D x-ray breast imaging systems

    PubMed Central

    Freed, Melanie; Park, Subok; Badano, Aldo

    2010-01-01

    Purpose: Accurate models of detector blur are crucial for performing meaningful optimizations of three-dimensional (3D) x-ray breast imaging systems as well as for developing reconstruction algorithms that faithfully reproduce the imaged object anatomy. So far, x-ray detector blur has either been ignored or modeled as a shift-invariant symmetric function for these applications. The recent development of a Monte Carlo simulation package called MANTIS has allowed detailed modeling of these detector blur functions and demonstrated the magnitude of the anisotropy for both tomosynthesis and breast CT imaging systems. Despite the detailed results that MANTIS produces, the long simulation times required make inclusion of these results impractical in rigorous optimization and reconstruction algorithms. As a result, there is a need for detector blur models that can be rapidly generated. Methods: In this study, the authors have derived an analytical model for deterministic detector blur functions, referred to here as point response functions (PRFs), of columnar CsI phosphor screens. The analytical model is x-ray energy and incidence angle dependent and draws on results from MANTIS to indirectly include complicated interactions that are not explicitly included in the mathematical model. Once the mathematical expression is derived, values of the coefficients are determined by a two-dimensional (2D) fit to MANTIS-generated results based on a figure-of-merit (FOM) that measures the normalized differences between the MANTIS and analytical model results averaged over a region of interest. A smaller FOM indicates a better fit. This analysis was performed for a monochromatic x-ray energy of 25 keV, a CsI scintillator thickness of 150 μm, and four incidence angles (0°, 15°, 30°, and 45°). Results: The FOMs comparing the analytical model to MANTIS for these parameters were 0.1951±0.0011, 0.1915±0.0014, 0.2266±0.0021, and 0.2416±0.0074 for 0°, 15°, 30°, and 45

  3. Use of a nationwide call center for Ebola response and monitoring during a 3-day house-to-house campaign - Sierra Leone, September 2014.

    PubMed

    Miller, Leigh Ann; Stanger, Emily; Senesi, Reynold Gb; DeLuca, Nick; Dietz, Patricia; Hausman, Leslie; Kilmarx, Peter H; Mermin, Jonathan

    2015-01-16

    During May 23, 2014-January 10, 2015, Sierra Leone reported 7,777 confirmed cases of Ebola virus disease (Ebola). In response to the epidemic, on August 5, Sierra Leone's Emergency Operations Center established a toll-free, nationwide Ebola call center. The purpose of the call center is to encourage public reporting of possible Ebola cases and deaths to public health officials and to provide health education about Ebola to callers. This information also functions as an "alert" system for public health officials and supports surveillance efforts for the response. National call center dispatchers call district-level response teams composed of surveillance officers and burial teams to inform them of reported deaths and possible Ebola cases. Members of these response teams investigate cases and conduct follow-up actions such as transporting ill persons to Ebola treatment units or providing safe, dignified medical burials as resources permit. The call center continues to operate. This report describes calls received during a 3-day national campaign and reports the results of an assessment of the call center operation during the campaign. PMID:25590683

  4. Comparison of analytical and wind-tunnel results for flutter and gust response of a transport wing with active controls

    NASA Technical Reports Server (NTRS)

    Abel, I.; Perry, B., III; Newsom, J. R.

    1982-01-01

    Two flutter suppression control laws wre designed and tested on a low speed aeroelastic model of a DC-10 derivative wing. Both control laws demontrated increases in flutter speed in excess of 25 percent above the passive wing flutter speed. In addition, one of the control laws was effective in reducing loads due to turbulence generated in the wind tunnel. The effect of variations in gain and phase on the closed-loop performance was measured and is compared with predictions. In general, both flutter and gust response predictions agree reasonably well with experimental data.

  5. Where does brain neural activation in aesthetic responses to visual art occur? Meta-analytic evidence from neuroimaging studies.

    PubMed

    Boccia, M; Barbetti, S; Piccardi, L; Guariglia, C; Ferlazzo, F; Giannini, A M; Zaidel, D W

    2016-01-01

    Here we aimed at finding the neural correlates of the general aspect of visual aesthetic experience (VAE) and those more strictly correlated with the content of the artworks. We applied a general activation likelihood estimation (ALE) meta-analysis to 47 fMRI experiments described in 14 published studies. We also performed four separate ALE analyses in order to identify the neural substrates of reactions to specific categories of artworks, namely portraits, representation of real-world-visual-scenes, abstract paintings, and body sculptures. The general ALE revealed that VAE relies on a bilateral network of areas, and the individual ALE analyses revealed different maximal activation for the artworks' categories as function of their content. Specifically, different content-dependent areas of the ventral visual stream are involved in VAE, but a few additional brain areas are involved as well. Thus, aesthetic-related neural responses to art recruit widely distributed networks in both hemispheres including content-dependent brain areas of the ventral visual stream. Together, the results suggest that aesthetic responses are not independent of sensory, perceptual, and cognitive processes. PMID:26619805

  6. Development of garlic bioactive compounds analytical methodology based on liquid phase microextraction using response surface design. Implications for dual analysis: Cooked and biological fluids samples.

    PubMed

    Ramirez, Daniela Andrea; Locatelli, Daniela Ana; Torres-Palazzolo, Carolina Andrea; Altamirano, Jorgelina Cecilia; Camargo, Alejandra Beatriz

    2017-01-15

    Organosulphur compounds (OSCs) present in garlic (Allium sativum L.) are responsible of several biological properties. Functional foods researches indicate the importance of quantifying these compounds in food matrices and biological fluids. For this purpose, this paper introduces a novel methodology based on dispersive liquid-liquid microextraction (DLLME) coupled to high performance liquid chromatography with ultraviolet detector (HPLC-UV) for the extraction and determination of organosulphur compounds in different matrices. The target analytes were allicin, (E)- and (Z)-ajoene, 2-vinyl-4H-1,2-dithiin (2-VD), diallyl sulphide (DAS) and diallyl disulphide (DADS). The microextraction technique was optimized using an experimental design, and the analytical performance was evaluated under optimum conditions. The desirability function presented an optimal value for 600μL of chloroform as extraction solvent using acetonitrile as dispersant. The method proved to be reliable, precise and accurate. It was successfully applied to determine OSCs in cooked garlic samples as well as blood plasma and digestive fluids. PMID:27542503

  7. Human-robot interactions during the robot-assisted urban search and rescue response at the World Trade Center.

    PubMed

    Casper, J; Murphy, R R

    2003-01-01

    The World Trade Center (WTC) rescue response provided an unfortunate opportunity to study the human-robot interactions (HRI) during a real unstaged rescue for the first time. A post-hoc analysis was performed on the data collected during the response, which resulted in 17 findings on the impact of the environment and conditions on the HRI: the skills displayed and needed by robots and humans, the details of the Urban Search and Rescue (USAR) task, the social informatics in the USAR domain, and what information is communicated at what time. The results of this work impact the field of robotics by providing a case study for HRI in USAR drawn from an unstaged USAR effort. Eleven recommendations are made based on the findings that impact the robotics, computer science, engineering, psychology, and rescue fields. These recommendations call for group organization and user confidence studies, more research into perceptual and assistive interfaces, and formal models of the state of the robot, state of the world, and information as to what has been observed. PMID:18238185

  8. Two analyte calibrations from the transient response of a single potentiometric sensor employed with the SIA technique.

    PubMed

    Cartas, Raul; Mimendia, Aitor; Legin, Andrey; Del Valle, Manel

    2010-01-15

    Simultaneous quantification of Cd(2+) and Pb(2+) in solution has been correctly targeted using the kinetic information from a single non-specific potentiometric sensor. Dual quantification was accomplished from the complex information in the transient response of an electrode used in a Sequential Injection Analysis (SIA) system and recorded after step injection of sample. Data was firstly preprocessed with the Discrete Wavelet Transform (DWT) to extract significant features and then fed into an Artificial Neural Network (ANN) for building the calibration model. DWT stage was optimized regarding the wavelet function and decomposition level, while the ANN stage was optimized on its structure. To simultaneously corroborate the effectiveness of the approach, two different potentiometric sensors were used as study case, one using a glass selective to Cd(2+) and another a PVC membrane selective to Pb(2+). PMID:20006109

  9. An Analytical Solution for Mechanical Responses Induced by Temperature and Air Pressure in a Lined Rock Cavern for Underground Compressed Air Energy Storage

    NASA Astrophysics Data System (ADS)

    Zhou, Shu-Wei; Xia, Cai-Chu; Du, Shi-Gui; Zhang, Ping-Yang; Zhou, Yu

    2015-03-01

    Mechanical responses induced by temperature and air pressure significantly affect the stability and durability of underground compressed air energy storage (CAES) in a lined rock cavern. An analytical solution for evaluating such responses is, thus, proposed in this paper. The lined cavern of interest consists of three layers, namely, a sealing layer, a concrete lining and the host rock. Governing equations for cavern temperature and air pressure, which involve heat transfer between the air and surrounding layers, are established first. Then, Laplace transform and superposition principle are applied to obtain the temperature around the lined cavern and the air pressure during the operational period. Afterwards, a thermo-elastic axisymmetrical model is used to analytically determine the stress and displacement variations induced by temperature and air pressure. The developments of temperature, displacement and stress during a typical operational cycle are discussed on the basis of the proposed approach. The approach is subsequently verified with a coupled compressed air and thermo-mechanical numerical simulation and by a previous study on temperature. Finally, the influence of temperature on total stress and displacement and the impact of the heat transfer coefficient are discussed. This paper shows that the temperature sharply fluctuates only on the sealing layer and the concrete lining. The resulting tensile hoop stresses on the sealing layer and concrete lining are considerably large in comparison with the initial air pressure. Moreover, temperature has a non-negligible effect on the lined cavern for underground compressed air storage. Meanwhile, temperature has a greater effect on hoop and longitudinal stress than on radial stress and displacement. In addition, the heat transfer coefficient affects the cavern stress to a higher degree than the displacement.

  10. Applications of NASA and NOAA Satellite Observations by NASA's Short-term Prediction Research and Transition (SPoRT) Center in Response to Natural Disasters

    NASA Technical Reports Server (NTRS)

    Molthan, Andrew L.; Burks, Jason E.; McGrath, Kevin M.; Jedlovec, Gary J.

    2012-01-01

    NASA s Short-term Prediction Research and Transition (SPoRT) Center supports the transition of unique NASA and NOAA research activities to the operational weather forecasting community. SPoRT emphasizes real-time analysis and prediction out to 48 hours. SPoRT partners with NOAA s National Weather Service (NWS) Weather Forecast Offices (WFOs) and National Centers to improve current products, demonstrate future satellite capabilities and explore new data assimilation techniques. Recently, the SPoRT Center has been involved in several activities related to disaster response, in collaboration with NOAA s National Weather Service, NASA s Applied Sciences Disasters Program, and other partners.

  11. Confirmatory factor analytic structure and measurement invariance of quantitative autistic traits measured by the social responsiveness scale-2.

    PubMed

    Frazier, Thomas W; Ratliff, Kristin R; Gruber, Chris; Zhang, Yi; Law, Paul A; Constantino, John N

    2014-01-01

    Understanding the factor structure of autistic symptomatology is critical to the discovery and interpretation of causal mechanisms in autism spectrum disorder. We applied confirmatory factor analysis and assessment of measurement invariance to a large (N = 9635) accumulated collection of reports on quantitative autistic traits using the Social Responsiveness Scale, representing a broad diversity of age, severity, and reporter type. A two-factor structure (corresponding to social communication impairment and restricted, repetitive behavior) as elaborated in the updated Diagnostic and Statistical Manual of Mental Disorders (5th ed.; DSM-5) criteria for autism spectrum disorder exhibited acceptable model fit in confirmatory factor analysis. Measurement invariance was appreciable across age, sex, and reporter (self vs other), but somewhat less apparent between clinical and nonclinical populations in this sample comprised of both familial and sporadic autism spectrum disorders. The statistical power afforded by this large sample allowed relative differentiation of three factors among items encompassing social communication impairment (emotion recognition, social avoidance, and interpersonal relatedness) and two factors among items encompassing restricted, repetitive behavior (insistence on sameness and repetitive mannerisms). Cross-trait correlations remained extremely high, that is, on the order of 0.66-0.92. These data clarify domains of statistically significant factoral separation that may relate to partially-but not completely-overlapping biological mechanisms, contributing to variation in human social competency. Given such robust intercorrelations among symptom domains, understanding their co-emergence remains a high priority in conceptualizing common neural mechanisms underlying autistic syndromes. PMID:24019124

  12. Kinetic modeling of Fluorine vacancy/F center creation in LiF:Mg,Ti including vacancy-interstitial recombination: Evaluating the factors leading to the lack of supralinearity in the optical absorption F center concentration dose response

    NASA Astrophysics Data System (ADS)

    Eliyahu, I.; Horowitz, Y. S.; Oster, L.; Mardor, I.; Druzhyna, S.; Biderman, S.

    2015-01-01

    Kinetic model simulations of charge carrier transport following irradiation of LiF:Mg,Ti (TLD-100) including Fluorine vacancy/F center creation by the radiation and dose-dependent vacancy-interstitial recombination are presented which describe the experimentally measured linear/exponentially saturating optical absorption dose response of the electron trapping centers at 4.0 eV, 4.77 eV, 5.08 eV (F band) and 5.45 eV. Linear/exponentially saturating dose response is commonly observed for centers which are not created by the radiation. The creation of Fluorine vacancies by the radiation could therefore be expected to lead to a supralinear dose response of the F center before the onset of saturation. Nonetheless, the dose response is linear from 10 Gy to 500 Gy and can be fitted with a dose-filling constant β = 6.1 · 10-5 Gy-1 corresponding to a 5% and 25% decrease from linearity at 103 Gy and 5 · 103 Gy respectively. The model attempts to resolve a central question concerning the mechanisms leading to the linear/exponentially saturating dose response of the F band even though Fluorine vacancies are being continuously created during the irradiation. The electron-trapping characteristics of the created vacancies are assumed to differ somewhat from the vacancies originally present in un-irradiated samples due to differences in their immediate environment. Vacancy-interstitial recombination for separation distances less than a critical distance, dc is demonstrated to be significant for D > 500 Gy (dc = 36 Å) and is an important mechanism contributing to the F center saturation at high dose-levels. The kinetic model accurately simulates the experimentally observed F center dose response over the entire investigated dose range of 10-105 Gy under the following conditions: (i) The concentration of vacancies initially present is unexpectedly high at ∼1023 m-3, possibly due to the highly doped, non-crystalline and hot-pressed nature of the LiF:Mg,Ti samples. (ii) The

  13. Analytical Searching.

    ERIC Educational Resources Information Center

    Pappas, Marjorie L.

    1995-01-01

    Discusses analytical searching, a process that enables searchers of electronic resources to develop a planned strategy by combining words or phrases with Boolean operators. Defines simple and complex searching, and describes search strategies developed with Boolean logic and truncation. Provides guidelines for teaching students analytical…

  14. Gold nanoparticles-induced enhancement of the analytical response of an electrochemical biosensor based on an organic-inorganic hybrid composite material.

    PubMed

    Barbadillo, M; Casero, E; Petit-Domínguez, M D; Vázquez, L; Pariente, F; Lorenzo, E

    2009-12-15

    The design and characterization of a new organic-inorganic hybrid composite material for glucose electrochemical sensing are described. This material is based on the entrapment of both gold nanoparticles (AuNPs) and glucose oxidase, which was chosen as a model, into a sol-gel matrix. The addition of spectroscopic grade graphite to this system, which confers conductivity, leads to the development of a material particularly attractive for electrochemical biosensor fabrication. The characterization of the hybrid composite material was performed using atomic force microscopy and scanning electron microscopy techniques. This composite material was applied to the determination of glucose in presence of hydroxymethylferrocene as a redox mediator. The system exhibits a clear electrocatalytic activity towards glucose, allowing its determination at 250 mV vs Ag/AgCl. The performance of the resulting enzyme biosensor was evaluated in terms of sensitivity, detection limit, linear response range, stability and accuracy. Finally, the enhancement of the analytical response of the resulting biosensor induced by the presence of gold nanoparticles was evaluated by comparison with a similar organic-inorganic hybrid composite material without AuNPs. PMID:19836554

  15. Analytical sedimentology

    SciTech Connect

    Lewis, D.W. . Dept. of Geology); McConchie, D.M. . Centre for Coastal Management)

    1994-01-01

    Both a self instruction manual and a cookbook'' guide to field and laboratory analytical procedures, this book provides an essential reference for non-specialists. With a minimum of mathematics and virtually no theory, it introduces practitioners to easy, inexpensive options for sample collection and preparation, data acquisition, analytic protocols, result interpretation and verification techniques. This step-by-step guide considers the advantages and limitations of different procedures, discusses safety and troubleshooting, and explains support skills like mapping, photography and report writing. It also offers managers, off-site engineers and others using sediments data a quick course in commissioning studies and making the most of the reports. This manual will answer the growing needs of practitioners in the field, either alone or accompanied by Practical Sedimentology, which surveys the science of sedimentology and provides a basic overview of the principles behind the applications.

  16. Designing Audience-Centered Interactive Voice Response Messages to Promote Cancer Screenings Among Low-Income Latinas

    PubMed Central

    De Jesus, Maria; Sprunck-Harrild, Kim M.; Tellez, Trinidad; Bastani, Roshan; Battaglia, Tracy A.; Michaelson, James S.; Emmons, Karen M.

    2014-01-01

    Introduction Cancer screening rates among Latinas are suboptimal. The objective of this study was to explore how Latinas perceive cancer screening and the use and design of interactive voice response (IVR) messages to prompt scheduling of 1 or more needed screenings. Methods Seven focus groups were conducted with Latina community health center patients (n = 40) in need of 1 or more cancer screenings: 5 groups were of women in need of 1 cancer screening (breast, cervical, or colorectal), and 2 groups were of women in need of multiple screenings. A bilingual researcher conducted all focus groups in Spanish using a semistructured guide. Focus groups were recorded, transcribed, and translated into English for analysis. Emergent themes were identified by using thematic content analysis. Results Participants were familiar with cancer screening and viewed it positively, although barriers to screening were identified (unaware overdue for screening, lack of physician referral, lack of insurance or insufficient insurance coverage, embarrassment or fear of screening procedures, fear of screening outcomes). Women needing multiple screenings voiced more concern about screening procedures, whereas women in need of a single screening expressed greater worry about the screening outcome. Participants were receptive to receiving IVR messages and believed that culturally appropriate messages that specified needed screenings while emphasizing the benefit of preventive screening would motivate them to schedule needed screenings. Conclusion Participants’ receptiveness to IVR messages suggests that these messages may be an acceptable strategy to promote cancer screening among underserved Latina patients. Additional research is needed to determine the effectiveness of IVR messages in promoting completion of cancer screening. PMID:24625364

  17. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND... operators have in managing work-based learning? (a) The center operator must emphasize and implement work-based learning programs for students through center program activities, including vocational...

  18. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND... operators have in managing work-based learning? (a) The center operator must emphasize and implement work-based learning programs for students through center program activities, including vocational...

  19. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND... operators have in managing work-based learning? (a) The center operator must emphasize and implement work-based learning programs for students through center program activities, including vocational...

  20. Meeting the Needs of Chinese English Language Learners at Writing Centers in America: A Proposed Culturally Responsive Model

    ERIC Educational Resources Information Center

    Wang, Peizhen; Machado, Crystal

    2015-01-01

    This paper describes the ways in which Writing Centers (WC) currently serve English Language Learners (ELL) at American universities. The authors argue that the pedagogy offered at these centers does not always meet the needs of the Chinese ELLs who make up the largest population of ELLs at American universities. The proposed supplemental model…

  1. Comprehensive Seismic Monitoring for Emergency Response and Hazards Assessment: Recent Developments at the USGS National Earthquake Information Center

    NASA Astrophysics Data System (ADS)

    Buland, R. P.; Guy, M.; Kragness, D.; Patton, J.; Erickson, B.; Morrison, M.; Bryon, C.; Ketchum, D.; Benz, H.

    2009-12-01

    The USGS National Earthquake Information Center (NEIC) has put into operation a new generation of seismic acquisition, processing and distribution subsystems that seamlessly integrate regional, national and global seismic network data for routine monitoring of earthquake activity and response to large, damaging earthquakes. The system, Bulletin Hydra, was designed to meet Advanced National Seismic System (ANSS) design goals to handle thousands of channels of real-time seismic data, compute and distribute time-critical seismic information for emergency response applications, and manage the integration of contributed earthquake products and information, arriving from near-real-time up to six weeks after an event. Bulletin Hydra is able meet these goals due to a modular, scalable, and flexible architecture that supports on-the-fly consumption of new data, readily allows for the addition of new scientific processing modules, and provides distributed client workflow management displays. Through the Edge subsystem, Bulletin Hydra accepts waveforms in half a dozen formats. In addition, Bulletin Hydra accepts contributed seismic information including hypocenters, magnitudes, moment tensors, unassociated and associated picks, and amplitudes in a variety of formats including earthworm import/export pairs and EIDS. Bulletin Hydra has state-driven algorithms for computing all IASPEI standard magnitudes (e.g. mb, mb_BB, ML, mb_LG, Ms_20, and Ms_BB) as well as Md, Ms(VMAX), moment tensor algorithms for modeling different portions of the wave-field at different distances (e.g. teleseismic body-wave, centroid, and regional moment tensors), and broadband depth. All contributed and derived data are centrally managed in an Oracle database. To improve on single station observations, Bulletin Hydra also does continuous real-time beam forming of high-frequency arrays. Finally, workflow management displays are used to assist NEIC analysts in their day-to-day duties. All combined

  2. Environmental Assessment and Finding of No Significant Impact: Expansion of the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center, Hanford Site, Richland, Washington

    SciTech Connect

    N /A

    2002-11-06

    The U.S. Department of Energy needs to provide additional cost-effective personal protection and public safety through expanding training and equipment testing facilities at the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center (HAMMER) on the Hanford Site. The U.S. Department of Energy (DOE) has prepared an Environmental Assessment (EA), DOE/EA-1412, for expanding training and equipment testing facilities at the Volpentest Hazardous Materials Management and Emergency Response Training and Education Center (HAMMER) on the Hanford Site, Richland, Washington. Based on the analysis in the EA, and considering tribal and agency comments, DOE has determined that the proposed action is not a major federal action significantly affecting the quality of the human environment within the meaning of the ''National Environmental Policy Act of 1969'' (NEPA). Therefore, the preparation of an Environmental Impact Statement (EIS) is not required.

  3. A Model for an Angular Velocity-Tuned Motion Detector Accounting for Deviations in the Corridor-Centering Response of the Bee

    PubMed Central

    Sabo, Chelsea; Gurney, Kevin; Vasilaki, Eleni; Marshall, James A. R.

    2016-01-01

    We present a novel neurally based model for estimating angular velocity (AV) in the bee brain, capable of quantitatively reproducing experimental observations of visual odometry and corridor-centering in free-flying honeybees, including previously unaccounted for manipulations of behaviour. The model is fitted using electrophysiological data, and tested using behavioural data. Based on our model we suggest that the AV response can be considered as an evolutionary extension to the optomotor response. The detector is tested behaviourally in silico with the corridor-centering paradigm, where bees navigate down a corridor with gratings (square wave or sinusoidal) on the walls. When combined with an existing flight control algorithm the detector reproduces the invariance of the average flight path to the spatial frequency and contrast of the gratings, including deviations from perfect centering behaviour as found in the real bee’s behaviour. In addition, the summed response of the detector to a unit distance movement along the corridor is constant for a large range of grating spatial frequencies, demonstrating that the detector can be used as a visual odometer. PMID:27148968

  4. A Model for an Angular Velocity-Tuned Motion Detector Accounting for Deviations in the Corridor-Centering Response of the Bee.

    PubMed

    Cope, Alex J; Sabo, Chelsea; Gurney, Kevin; Vasilaki, Eleni; Marshall, James A R

    2016-05-01

    We present a novel neurally based model for estimating angular velocity (AV) in the bee brain, capable of quantitatively reproducing experimental observations of visual odometry and corridor-centering in free-flying honeybees, including previously unaccounted for manipulations of behaviour. The model is fitted using electrophysiological data, and tested using behavioural data. Based on our model we suggest that the AV response can be considered as an evolutionary extension to the optomotor response. The detector is tested behaviourally in silico with the corridor-centering paradigm, where bees navigate down a corridor with gratings (square wave or sinusoidal) on the walls. When combined with an existing flight control algorithm the detector reproduces the invariance of the average flight path to the spatial frequency and contrast of the gratings, including deviations from perfect centering behaviour as found in the real bee's behaviour. In addition, the summed response of the detector to a unit distance movement along the corridor is constant for a large range of grating spatial frequencies, demonstrating that the detector can be used as a visual odometer. PMID:27148968

  5. Selective utilization of Toll-like receptor and MyD88 signaling in B cells for enhancement of the anti-viral germinal center response

    PubMed Central

    Hou, Baidong; Saudan, Philippe; Ott, Gary; Wheeler, Matthew L.; Ji, Ming; Kuzmich, Lili; Lee, Linda M.; Coffman, Robert L.; Bachmann, Martin F.; DeFranco, Anthony L.

    2011-01-01

    Summary The contribution of Toll-like receptor (TLR) signaling to T cell-dependent (TD) antibody responses was assessed by using mice lacking the TLR signaling adaptor MyD88 in individual cell types. When a soluble TLR9 ligand was used as adjuvant for a protein antigen, MyD88 was required in dendritic cells but not in B cells to enhance the TD antibody response, regardless of the inherent immunogenicity of the antigen. In contrast, a TLR9 ligand contained within a virus-like particle substantially augmented the TD germinal center IgG antibody response, and this augmentation required B cell MyD88. The ability of B cells to discriminate between antigens based the physical form of a TLR ligand likely reflects an adaptation to facilitate strong anti-viral antibody responses. PMID:21353603

  6. 41 CFR 102-192.140 - What are your general responsibilities as a Federal mail center manager?

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 41 Public Contracts and Property Management 3 2011-01-01 2011-01-01 false What are your general... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Mail Center Manager Requirements § 102-192.140 What are your...

  7. 41 CFR 102-192.140 - What are your general responsibilities as a Federal mail center manager?

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 41 Public Contracts and Property Management 3 2012-01-01 2012-01-01 false What are your general... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Mail Center Manager Requirements § 102-192.140 What are your...

  8. 41 CFR 102-192.140 - What are your general responsibilities as a Federal mail center manager?

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 41 Public Contracts and Property Management 3 2014-01-01 2014-01-01 false What are your general... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Mail Center Manager Requirements § 102-192.140 What are your...

  9. 41 CFR 102-192.140 - What are your general responsibilities as a Federal mail center manager?

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 41 Public Contracts and Property Management 3 2013-07-01 2013-07-01 false What are your general... Management Federal Property Management Regulations System (Continued) FEDERAL MANAGEMENT REGULATION ADMINISTRATIVE PROGRAMS 192-MAIL MANAGEMENT Mail Center Manager Requirements § 102-192.140 What are your...

  10. A Community Response to Rape. Polk County Rape/Sexual Assault Care Center, Des Moines, Iowa. An Exemplary Project.

    ERIC Educational Resources Information Center

    Bryant, Gerald; Cirel, Paul

    In Polk County, Iowa, criminal justice agencies and concerned citizens work together to lessen the burden on the rape victim and to increase the chance of ultimate conviction and sentencing in rape and sexual assault cases. The Rape/Sexual Assault Care Center offers medical and social supportive services to victims, aids law enforcement and…

  11. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND... managing work-based learning? (a) The center operator must emphasize and implement work-based learning... arrangements with employers. Work-based learning must be under actual working conditions and must be...

  12. 20 CFR 670.515 - What responsibilities do the center operators have in managing work-based learning?

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... have in managing work-based learning? 670.515 Section 670.515 Employees' Benefits EMPLOYMENT AND... managing work-based learning? (a) The center operator must emphasize and implement work-based learning... arrangements with employers. Work-based learning must be under actual working conditions and must be...

  13. Analytical Device

    NASA Technical Reports Server (NTRS)

    1983-01-01

    In the mid 60s under contract with NASA, Dr. Benjamin W. Grunbaum was responsible for the development of an automated electrophoresis device that would work in the weightless environment of space. The device was never used in space but was revived during the mid 70s as a technology utilization project aimed at an automated system for use on Earth. The advanced system became known as the Grunbaum System for electrophoresis. It is a versatile, economical assembly for rapid separation of specific blood proteins in very small quantities, permitting their subsequent identification and quantification.

  14. Atomistic simulation combined with analytic theory to study the response of the P-selectin/PSGL-1 complex to an external force.

    PubMed

    Gunnerson, Kim N; Pereverzev, Yuriy V; Prezhdo, Oleg V

    2009-02-19

    Steered molecular dynamics simulations are combined with analytic theory in order to gain insights into the properties of the P-selectin/PSGL-1 catch-slip bond at the atomistic level of detail. The simulations allow us to monitor the conformational changes in the P-selectin/PSGL-1 complex in response to an external force, while the theory provides a unified framework bridging the simulation data with experiment over 9 orders of magnitude. The theory predicts that the probability of bond dissociation by the catch mechanism is extremely low in the simulations; however, a few or even a single trajectory can be sufficient for characterization of the slip mechanism. Theoretical analysis of the simulation data shows that the bond responds to the force in a highly nonlinear way, with the bond stiffness changing considerably as a function of the force ramp rate. The Langevin description of the simulation provides spring constants of the proteins and the binding interaction and gives the friction coefficient associated with the receptor-ligand motion in water. The estimated relaxation time shows that the simple probabilistic description is accurate for the experimental regime and remains approximately valid for the high ramp rates used in simulations. The simulations establish that bond deformation occurs primarily within the P-selectin receptor region. The two interaction sites within the binding pocket dissociate sequentially, raising the possibility of observing these independent rupture events in experiment. The stronger interaction that determines the overall properties of the bond dissociates first, indicating that the experimental data indeed capture the main rupture event and not the secondary weaker site rupture. The main rupture event involves the interaction between the calcium ion of the receptor and the ligand residue FUC-623. It is followed by new interactions, supporting the sliding-rebinding behavior observed in the earlier simulation [ Lou, J. Zhu, C

  15. Plastidial metabolite MEcPP induces a transcriptionally centered stress-response hub via the transcription factor CAMTA3.

    PubMed

    Benn, Geoffrey; Bjornson, Marta; Ke, Haiyan; De Souza, Amancio; Balmond, Edward I; Shaw, Jared T; Dehesh, Katayoon

    2016-08-01

    The general stress response (GSR) is an evolutionarily conserved rapid and transient transcriptional reprograming of genes central for transducing environmental signals into cellular responses, leading to metabolic and physiological readjustments to cope with prevailing conditions. Defining the regulatory components of the GSR will provide crucial insight into the design principles of early stress-response modules and their role in orchestrating master regulators of adaptive responses. Overaccumulation of methylerythritol cyclodiphosphate (MEcPP), a bifunctional chemical entity serving as both a precursor of isoprenoids produced by the plastidial methylerythritol phosphate (MEP) pathway and a stress-specific retrograde signal, in ceh1 (constitutively expressing hydroperoxide lyase1)-mutant plants leads to large-scale transcriptional alterations. Bioinformatic analyses of microarray data in ceh1 plants established the overrepresentation of a stress-responsive cis element and key GSR marker, the rapid stress response element (RSRE), in the promoters of robustly induced genes. ceh1 plants carrying an established 4×RSRE:Luciferase reporter for monitoring the GSR support constitutive activation of the response in this mutant background. Genetics and pharmacological approaches confirmed the specificity of MEcPP in RSRE induction via the transcription factor CALMODULIN-BINDING TRANSCRIPTION ACTIVATOR 3 (CAMTA3), in a calcium-dependent manner. Moreover, CAMTA3-dependent activation of IRE1a (inositol-requiring protein-1) and bZIP60 (basic leucine zipper 60), two RSRE containing unfolded protein-response genes, bridges MEcPP-mediated GSR induction to the potentiation of protein-folding homeostasis in the endoplasmic reticulum. These findings introduce the notion of transcriptional regulation by a key plastidial retrograde signaling metabolite that induces nuclear GSR, thereby offering a window into the role of interorgannellar communication in shaping cellular adaptive

  16. Johnson Space Center Overview

    NASA Technical Reports Server (NTRS)

    Gafka, Tammy; Terrier, Doug; Smith, James

    2011-01-01

    This slide presentation is a review of the work of Johnson Space Center. It includes a section on technology development areas, (i.e., composite structures, non-destructive evaluation, applied nanotechnology, additive manufacturing, and fracture and fatigue analytical methods), a section on structural analysis capabilities within NASA/JSC and a section on Friction stir welding and laser peening.

  17. Modeling Real-Time Coordination of Distributed Expertise and Event Response in NASA Mission Control Center Operations

    NASA Astrophysics Data System (ADS)

    Onken, Jeffrey

    This dissertation introduces a multidisciplinary framework for the enabling of future research and analysis of alternatives for control centers for real-time operations of safety-critical systems. The multidisciplinary framework integrates functional and computational models that describe the dynamics in fundamental concepts of previously disparate engineering and psychology research disciplines, such as group performance and processes, supervisory control, situation awareness, events and delays, and expertise. The application in this dissertation is the real-time operations within the NASA Mission Control Center in Houston, TX. This dissertation operationalizes the framework into a model and simulation, which simulates the functional and computational models in the framework according to user-configured scenarios for a NASA human-spaceflight mission. The model and simulation generates data according to the effectiveness of the mission-control team in supporting the completion of mission objectives and detecting, isolating, and recovering from anomalies. Accompanying the multidisciplinary framework is a proof of concept, which demonstrates the feasibility of such a framework. The proof of concept demonstrates that variability occurs where expected based on the models. The proof of concept also demonstrates that the data generated from the model and simulation is useful for analyzing and comparing MCC configuration alternatives because an investigator can give a diverse set of scenarios to the simulation and the output compared in detail to inform decisions about the effect of MCC configurations on mission operations performance.

  18. Synthesis and Photophysical Characterization of an Artificial Photosynthetic Reaction Center Exhibiting Acid-Responsive Regulation of Charge Separation

    NASA Astrophysics Data System (ADS)

    Pahk, Ian

    Non-photochemical quenching (NPQ) is a photoprotective regulatory mechanism essential to the robustness of the photosynthetic apparatus of green plants. Energy flow within the low-light adapted reaction centers is dynamically optimized to match the continuously fluctuating light conditions found in nature. Activated by compartmentalized decreases in pH resulting from photosynthetic activity during periods of elevated photon flux, NPQ induces rapid thermal dissipation of excess excitation energy that would otherwise overwhelm the apparatus's ability to consume it. Consequently, the frequency of charge separation decreases and the formation of potentially deleterious, high-energy intermediates slows, thereby reducing the threat of photodamage by disallowing their accumulation. Herein is described the synthesis and photophysical analysis of a molecular triad that mimics the effects of NPQ on charge separation within the photosynthetic reaction centers. Steady-state absorption and emission, time-resolved fluorescence, and transient absorption spectroscopies were used to demonstrate reversible quenching of the first singlet excited state affecting the quantum yield of charge separation by approximately one order of magnitude. As in the natural system, the populations of unquenched and quenched states and, therefore, the overall yields of charge separation were found to be dependent upon acid concentration.

  19. MERRA Analytic Services

    NASA Astrophysics Data System (ADS)

    Schnase, J. L.; Duffy, D. Q.; McInerney, M. A.; Tamkin, G. S.; Thompson, J. H.; Gill, R.; Grieg, C. M.

    2012-12-01

    MERRA Analytic Services (MERRA/AS) is a cyberinfrastructure resource for developing and evaluating a new generation of climate data analysis capabilities. MERRA/AS supports OBS4MIP activities by reducing the time spent in the preparation of Modern Era Retrospective-Analysis for Research and Applications (MERRA) data used in data-model intercomparison. It also provides a testbed for experimental development of high-performance analytics. MERRA/AS is a cloud-based service built around the Virtual Climate Data Server (vCDS) technology that is currently used by the NASA Center for Climate Simulation (NCCS) to deliver Intergovernmental Panel on Climate Change (IPCC) data to the Earth System Grid Federation (ESGF). Crucial to its effectiveness, MERRA/AS's servers will use a workflow-generated realizable object capability to perform analyses over the MERRA data using the MapReduce approach to parallel storage-based computation. The results produced by these operations will be stored by the vCDS, which will also be able to host code sets for those who wish to explore the use of MapReduce for more advanced analytics. While the work described here will focus on the MERRA collection, these technologies can be used to publish other reanalysis, observational, and ancillary OBS4MIP data to ESGF and, importantly, offer an architectural approach to climate data services that can be generalized to applications and customers beyond the traditional climate research community. In this presentation, we describe our approach, experiences, lessons learned,and plans for the future.; (A) MERRA/AS software stack. (B) Example MERRA/AS interfaces.

  20. Is there a typical germinal center? A large-scale immunohistological study on the cellular composition of germinal centers during the hapten-carrier-driven primary immune response in mice.

    PubMed

    Wittenbrink, Nicole; Klein, Anke; Weiser, Armin A; Schuchhardt, Johannes; Or-Guil, Michal

    2011-12-15

    Germinal centers (GCs) are complex, multicell-type, transient structures that form in secondary lymphatic tissues in response to T cell-dependent stimulation. This process is crucial to the adaptive immune response because it is the source of affinity maturation and long-lived B cell memory. Our previous studies showed that the growth of murine splenic GCs is nonsynchronized, involving broad-volume distributions of individual GCs at any time. This raises the question whether such a thing as a typical GC exists. To address this matter, we acquired large-scale confocal data on GCs throughout the course of the 2-phenyl-5-oxazolone chicken serum albumin-driven primary immune response in BALB/c mice. Semiautomated image analysis of 3457 GC sections revealed that, although there is no typical GC in terms of size, GCs have a typical cellular composition in that the cell ratios of resident T cells, macrophages, proliferating cells, and apoptotic nuclei are maintained during the established phase of the response. Moreover, our data provide evidence that the dark zone (DZ) and light zone (LZ) compartments of GCs are about the same size and led us to estimate that the minimal cell loss rate in GCs is 3% per hour. Furthermore, we found that the population of GC macrophages is larger and more heterogeneous than previously thought, and that despite enrichment of T cells in the LZ, the DZ of murine splenic GCs is not poor in T cells. DZ and LZ differ in the T cell-to-macrophage ratio rather than in the density of T cells. PMID:22102720

  1. The National Atmospheric Release Advisory Center (NARAC) Modeling and Decision Support System for Radiological and Nuclear Emergency Preparedness and Response

    SciTech Connect

    Nasstrom, J S; Sugiyama, G; Baskett, R; Larsen, S; Bradley, M

    2005-04-01

    This paper describes the tools and services provided by the National Atmospheric Release Advisory Center (NARAC) at Lawrence Livermore National Laboratory (LLNL) for modeling the impacts of airborne hazardous materials. NARAC provides atmospheric plume modeling tools and services for chemical, biological, radiological, and nuclear airborne hazards. NARAC can simulate downwind effects from a variety of scenarios, including fires, industrial and transportation accidents, radiation dispersal device explosions, hazardous material spills, sprayers, nuclear power plant accidents, and nuclear detonations. NARAC collaborates with several government agencies and laboratories in order to accomplish its mission. The NARAC suite of software tools include simple stand-alone, local-scale plume modeling tools for end-user's computers, and Web- and Internet-based software to access advanced modeling tools and expert analyses from the national center at LLNL. Initial automated, 3-D predictions of plume exposure limits and protective action guidelines for emergency responders and managers are available from the center in 5-10 minutes. These can be followed immediately by quality-assured, refined analyses by 24 x 7 on-duty or on-call NARAC staff. NARAC continues to refine calculations using updated on-scene information, including measurements, until all airborne releases have stopped and the hazardous threats are mapped and impacts assessed. Model predictions include the 3-D spatial and time-varying effects of weather, land use, and terrain, on scales from the local to regional to global. Real-time meteorological data and forecasts are provided by redundant communications links to the U.S. National Oceanic and Atmospheric Administration (NOAA), U.S. Navy, and U.S. Air Force, as well as an in-house mesoscale numerical weather prediction model. NARAC provides an easy-to-use Geographical Information System (GIS) for display of plume predictions with affected population counts and

  2. Fostering an Adolescent-Centered Community Responsive to Student Needs: Lessons Learned and Suggestions for Middle Level Educators

    ERIC Educational Resources Information Center

    Ellerbock, Cheryl R.; Kiefer, Sarah M.

    2014-01-01

    Young adolescents have unique basic and developmental needs. Middle level educators are best able to reach and teach young adolescents when they understand students' needs and when the school environment, including its organizational structures and teacher practices, are responsive to these needs. Findings from a recently conducted…

  3. "Koladeras", Literacy Educators of the Cape Verdean Diaspora: A Cape Verdean African Centered Call and Response Methodology

    ERIC Educational Resources Information Center

    Barros, Jessica M.

    2012-01-01

    "Koladeras" are women who use call and response in impromptu songs that may contain proverbs, stories about the community, their life experiences, and who and what they see in their world from their own perspective. Via qualitative methods of (auto)ethnography, personal and life story narratives, and interviews, I look at how "koladeras'" as…

  4. A graphical and analytical method to determine the transient response for an ideal transmission line, loaded by a time-varying impedance

    SciTech Connect

    Krehl, P.; Novender, W.R.

    1985-04-01

    Based on Bergeron's theory, a graphical and analytical method has been worked out to determine the dynamic load characteristic and load transients for a time-varying load impedance, pulsed by a lossless transmission line. The analytical solution has been compared with the numerical solution of the network analysis code SCEPTRE. A parametric study for a time-decreasing load function, demonstrated by the example of a vacuum-discharge flash X-ray tube, reveals that the dynamic load characteristic I /SUB L/ (U /SUB L/ (t),U/sub 0/,Z/sub 0/,T) and the transients U /SUB L/ (t,U/sub 0/,Z/sub 0/,T) and I /SUB L/ (t,U/sub 0/,Z/sub 0/,T) are dependent on the diode function Z /SUB L/ (t) as well as on the charging voltage U/sub 0/ and the characterics T and Z/sub 0/ of the line.

  5. A review of the Centers for Disease Control and Prevention's response to the HIV/AIDS crisis among Blacks in the United States, 1981-2009.

    PubMed

    Sutton, Madeline Y; Jones, Rhondette L; Wolitski, Richard J; Cleveland, Janet C; Dean, Hazel D; Fenton, Kevin A

    2009-10-01

    Among US racial/ethnic groups, Blacks are at the highest risk of acquiring HIV/AIDS. In response, the Centers for Disease Control and Prevention (CDC) has launched the Heightened National Response to Address the HIV/AIDS Crisis Among African Americans, which seeks to engage public and nonpublic partners in a synergistic effort to prevent HIV among Blacks. The CDC also recently launched Act Against AIDS, a campaign to refocus attention on the domestic HIV/AIDS crisis. Although the CDC's efforts to combat HIV/AIDS among Blacks have achieved some success, more must be done to address this crisis. New initiatives include President Obama's goal of developing a National HIV/AIDS Strategy to reduce HIV incidence, decrease HIV-related health disparities, and increase access to care, especially among Blacks and other disproportionately affected populations. PMID:19797748

  6. Response to the comment by Henry Kahn and Dennis Santella on a summary of the development of a signature for detection of residual dust from the collapse of the World Trade Center buildings

    USGS Publications Warehouse

    Meeker, Gregory P.; Lowers, Heather; Lioy, Paul J.; Lippmann, Morton

    2010-01-01

    A response by Gregory P. Meeker and colleagues to a commentary on their article on the development of a signature for detection of residual dust from the collapse of the World Trade Center buildings is presented

  7. Workplace response of companies exposed to the 9/11 World Trade Center attack: a focus-group study.

    PubMed

    North, Carol S; Pfefferbaum, Betty; Hong, Barry A; Gordon, Mollie R; Kim, You-Seung; Lind, Lisa; Pollio, David E

    2013-01-01

    The terrorist attacks of 11 September 2001 (9/11) left workplaces in pressing need of a mental health response capability. Unaddressed emotional sequelae may be devastating to the productivity and economic stability of a company's workforce. In the second year after the attacks, 85 employees of five highly affected agencies participated in 12 focus groups to discuss workplace mental health issues. Managers felt ill prepared to manage the magnitude and the intensity of employees' emotional responses. Rapid return to work, provision of workplace mental health services, and peer support were viewed as contributory to emotional recovery. Formal mental health services provided were perceived as insufficient. Drawing on their post-9/11 workplace experience, members of these groups identified practical measures that they found helpful in promoting healing outside of professional mental health services. These measures, consistent with many principles of psychological first aid, may be applied by workplace leaders who are not mental health professionals. PMID:23066661

  8. Workplace response of companies exposed to the 9/11 World Trade Center attack: a focus-group study

    PubMed Central

    North, Carol S.; Pfefferbaum, Betty; Hong, Barry A.; Gordon, Mollie R.; Kim, You-Seung; Lind, Lisa; Pollio, David E.

    2014-01-01

    The terrorist attacks of 11 September 2001 (9/11) left workplaces in pressing need of a mental health response capability. Unaddressed emotional sequelae may be devastating to the productivity and economic stability of a company’s workforce. In the second year after the attacks, 85 employees of five highly affected agencies participated in 12 focus groups to discuss workplace mental health issues. Managers felt ill prepared to manage the magnitude and the intensity of employees’ emotional responses. Rapid return to work, provision of workplace mental health services, and peer support were viewed as contributory to emotional recovery. Formal mental health services provided were perceived as insufficient. Drawing on their post-9/11 workplace experience, members of these groups identified practical measures that they found helpful in promoting healing outside of professional mental health services. These measures, consistent with many principles of psychological first aid, may be applied by workplace leaders who are not mental health professionals. PMID:23066661

  9. A new reportable disease is born: Taiwan Centers for Disease Control's response to emerging Zika virus infection.

    PubMed

    Huang, Angela Song-En; Shu, Pei-Yun; Yang, Chin-Hui

    2016-04-01

    Zika virus infection, usually a mild disease transmitted through the bite of Aedes mosquitos, has been reported to be possibly associated with microcephaly and neurologic complications. Taiwan's first imported case of Zika virus infection was found through fever screening at airport entry in January 2016. No virus was isolated from patient's blood taken during acute illness; however, PCR products showed that the virus was of Asian lineage closely related to virus from Cambodia. To prevent Zika virus from spreading in Taiwan, the Taiwan Centers for Disease Control has strengthened efforts in quarantine and surveillance, increased Zika virus infection diagnostic capacity, implemented healthcare system preparedness plans, and enhanced vector control program through community mobilization and education. Besides the first imported case, no additional cases of Zika virus infection have been identified. Furthermore, no significant increase in the number of microcephaly or Guillain- Barré Syndrome has been observed in Taiwan. To date, there have been no autochthonous transmissions of Zika virus infection. PMID:27013110

  10. RESULTS OF THE 2008 UT MODELING BENCHMARK OBTAINED WITH 2 SEMI-ANALYTICAL MODELS: RESPONSES OF FLAT BOTTOM HOLES AT VARIOUS DEPTHS UNDER INTERFACES OF DIFFERENT CURVATURES

    SciTech Connect

    Raillon, R.; Mahaut, S.; Leymarie, N.; Lonne, S.; Spies, M.

    2009-03-03

    This paper presents the results of the 2008 UT modeling benchmark with the ultrasonic simulation code for predicting echo-responses from flaws integrated into the Civa software platform and with the code developed by M. Spies. UT configurations addressed are similar to 2007 ones, to better understand some responses obtained last year. Experimental results proposed concern the responses of flat bottom holes at different depths inside surface curved blocks inspected by an immersion probe in normal incidence. They investigate the influence of surface curvature upon the amplitude and shape of flaw responses. Comparison of the simulated and experimental results is discussed.

  11. Proposed Construction of the Madera County Educational Center in the State Center Community College District. A Report to the Governor and Legislature in Response to a Request from the Board of Governors of the California Community Colleges.

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    In this report, the California Postsecondary Education Commission responds to a request by the Chancellor of the California Community Colleges to review the need for and location of a new educational center, the Madera County Educational Center, north of Fresno within the State Center Community College District. The report contains nine…

  12. Let's Talk... Analytics

    ERIC Educational Resources Information Center

    Oblinger, Diana G.

    2012-01-01

    Talk about analytics seems to be everywhere. Everyone is talking about analytics. Yet even with all the talk, many in higher education have questions about--and objections to--using analytics in colleges and universities. In this article, the author explores the use of analytics in, and all around, higher education. (Contains 1 note.)

  13. Analytics for Education

    ERIC Educational Resources Information Center

    MacNeill, Sheila; Campbell, Lorna M.; Hawksey, Martin

    2014-01-01

    This article presents an overview of the development and use of analytics in the context of education. Using Buckingham Shum's three levels of analytics, the authors present a critical analysis of current developments in the domain of learning analytics, and contrast the potential value of analytics research and development with real world…

  14. An analytical solution for the elastic response to surface loads imposed on a layered, transversely isotropic and self-gravitating Earth

    NASA Astrophysics Data System (ADS)

    Pan, E.; Chen, J. Y.; Bevis, M.; Bordoni, A.; Barletta, V. R.; Molavi Tabrizi, A.

    2015-12-01

    We present an analytical solution for the elastic deformation of an elastic, transversely isotropic, layered and self-gravitating Earth by surface loads. We first introduce the vector spherical harmonics to express the physical quantities in the layered Earth. This reduces the governing equations to a linear system of equations for the expansion coefficients. We then solve for the expansion coefficients analytically under the assumption (i.e. approximation) that in the mantle, the density in each layer varies as 1/r (where r is the radial coordinate) while the gravity is constant and that in the core the gravity in each layer varies linearly in r with constant density. These approximations dramatically simplify the subsequent mathematical analysis and render closed-form expressions for the expansion coefficients. We implement our solution in a MATLAB code and perform a benchmark which shows both the correctness of our solution and the implementation. We also calculate the load Love numbers (LLNs) of the PREM Earth for different degrees of the Legendre function for both isotropic and transversely isotropic, layered mantles with different core models, demonstrating for the first time the effect of Earth anisotropy on the LLNs.

  15. Extracting the Building Response with QCN-Taiwan Sensor Data: Application to the building of Science Education Center, National Taiwan Normal University

    NASA Astrophysics Data System (ADS)

    Liang, W.; Lee, W.; Chen, K. H.; Yen, E. H.; Lawrence, J. F.; Lin, C.; Chang, C.

    2013-12-01

    We have taken advantage of strong motion sensor data collected from the Taiwan Quake Catcher Network (QCN-Taiwan) in 2012 to extract the building response of the Science Education Center, National Taiwan Normal University. The QCN-Taiwan project is mainly aimed to construct a school seismic network with low-cost sensors for the purpose of earthquake science education in Taiwan. So far there are more than 60 volunteer QCN sites deployed island-wide in the campus of Taiwan. There were 10 MEMS sensors deployed in the basement and every story from 1 to 8 in the building. We analyze the acceleration data generated from 3 moderate to strong earthquakes (6.4≧ML≧5.2) to study the characteristic frequencies and responses of the building. Both deconvolution and H/V spectral ratio methods are used to characterize the building response. The dominant frequency in the NS direction is 1.7-1.9 Hz, which is slightly higher than recorded in the EW direction of 1.65-1.8 Hz. In addition, the amplification is much significant in levels higher than the 3rd floor in the frequency range of 1-3 Hz as shown in the H/V spectral ratio diagrams. We deconvolve all waveforms with both the motions in the ground and top floors to derive the building responses, respectively. Results show that the 1.6 Hz resonance is dominant in levels higher than the 4th floor for waveforms deconvolved with the basement data. On the other hand, both the up-going and down-going shear waves are clearly seen in the waveforms deconvoled with top floor data, which tells a shear velocity of ~190 m/s. We have proven that the strong motion data collected by the low-cost QCN MEMS sensors during large earthquakes is useful for extracting the building response.

  16. 88 hours: the U.S. Geological Survey National Earthquake Information Center response to the March 11, 2011 Mw 9.0 Tohoku earthquake

    USGS Publications Warehouse

    Wald, David J.; Hayes, Gavin P.; Benz, Harley M.; Earle, Paul; Briggs, Richard W.

    2011-01-01

    The M 9.0 11 March 2011 Tohoku, Japan, earthquake and associated tsunami near the east coast of the island of Honshu caused tens of thousands of deaths and potentially over one trillion dollars in damage, resulting in one of the worst natural disasters ever recorded. The U.S. Geological Survey National Earthquake Information Center (USGS NEIC), through its responsibility to respond to all significant global earthquakes as part of the National Earthquake Hazards Reduction Program, quickly produced and distributed a suite of earthquake information products to inform emergency responders, the public, the media, and the academic community of the earthquake's potential impact and to provide scientific background for the interpretation of the event's tectonic context and potential for future hazard. Here we present a timeline of the NEIC response to this devastating earthquake in the context of rapidly evolving information emanating from the global earthquake-response community. The timeline includes both internal and publicly distributed products, the relative timing of which highlights the inherent tradeoffs between the requirement to provide timely alerts and the necessity for accurate, authoritative information. The timeline also documents the iterative and evolutionary nature of the standard products produced by the NEIC and includes a behind-the-scenes look at the decisions, data, and analysis tools that drive our rapid product distribution.

  17. The protein responsible for center A/B in spinach photosystem I: isolation with iron-sulfur cluster(s) and complete sequence analysis.

    PubMed

    Oh-oka, H; Takahashi, Y; Kuriyama, K; Saeki, K; Matsubara, H

    1988-06-01

    The 9 kDa polypeptide from spinach photosystem I (PS I) complex was isolated with iron-sulfur cluster(s) by an n-butanol extraction procedure under anaerobic conditions. The polypeptide was soluble in a saline solution and contained non-heme irons and inorganic sulfides. The absorption spectrum of this iron-sulfur protein was very similar to those of bacterial-type ferredoxins. The amino acid sequence of the polypeptide was determined by using a combination of gas-phase sequencer and conventional procedures. It was composed of 80 amino acid residues giving a molecular weight of 8,894, excluding iron and sulfur atoms. The sequence showed the typical distribution of cysteine residues found in bacterial-type ferredoxins and was highly homologous (91% homology) to that deduced from the chloroplast gene, frxA, of liverwort, Marchantia polymorpha. The 9 kDa polypeptide is considered to be the iron-sulfur protein responsible for the electron transfer reaction in PS I from center X to [2Fe-2S] ferredoxin, namely a polypeptide with center(s) A and/or B in PS I complex. It is noteworthy that the 9 kDa polypeptide was rather hydrophilic and a little basic in terms of the primary structure. A three-dimensional structure was simulated on the basis of the tertiary structure of Peptococcus aerogenes [8Fe-8S] ferredoxin, and the portions in the molecule probably involved in contacting membranes or other polypeptides were indicated. The phylogenetic implications of the structure of the present polypeptide as compared with those of several bacterial-type ferredoxins are discussed. PMID:3049567

  18. URBAN STUDIES CENTER.

    ERIC Educational Resources Information Center

    HEBOUT, JOHN E.

    THE CENTER WORKS WITH RUTGERS UNIVERSITY TO MAKE USE OF URBAN STUDIES IN APPROPRIATE RESEARCH AND TEACHING PROGRAMS AND IN OTHER INTELLECTUAL SERVICES TO THE COMMUNITY. THE FIVE MAIN RESPONSIBILITIES OF THE CENTER - EXTENSION, RESEARCH AND EDUCATION, LIBRARY SERVICES, OPPORTUNITIES EXPANSION PROJECT, AND THE URBAN FELLOWSHIP PROGRAM - ARE…

  19. RESPONSE PROTOCOL TOOLBOX: PLANNING FOR AND RESPONDING TO DRINKING WATER CONTAMINATION THREATS AND INCIDENTS. MODULE 4: ANALYTICAL GUIDE. INTERIM FINAL - DECEMBER 2003

    EPA Science Inventory

    The interim final Response Protocol Toolbox: Planning for and Responding to Contamination Threats to Drinking Water Systems is designed to help the water sector effectively and appropriately respond to intentional contamination threats and incidents. It was produced by EPA, buil...

  20. Organizing center for the bifurcation analysis of a generalized Gause model with prey harvesting and Holling response function of type III

    NASA Astrophysics Data System (ADS)

    Laurin, Sophie; Rousseau, Christiane

    The present note is an addendum to the paper of Etoua-Rousseau (2010) [1] which presented a study of a generalized Gause model with prey harvesting and a generalized Holling response function of type III: p(x)={mx}/{ax+bx+1}. Complete bifurcation diagrams were proposed, but some parts were conjectural. An organizing center for the bifurcation diagram was given by a nilpotent point of saddle type lying on an invariant line and of codimension greater than or equal to 3. This point was of codimension 3 when b≠0, and was conjectured to be of infinite codimension when b=0. This conjecture was in line with a second conjecture that the Hopf bifurcation of order 2 degenerates to a Hopf bifurcation of infinite codimension when b=0. In this note we prove these two conjectures.

  1. Assessment of Early Toxicity and Response in Patients Treated With Proton and Carbon Ion Therapy at the Heidelberg Ion Therapy Center Using the Raster Scanning Technique

    SciTech Connect

    Rieken, Stefan; Habermehl, Daniel; Nikoghosyan, Anna; Jensen, Alexandra; Haberer, Thomas; Jaekel, Oliver; Muenter, Marc W.; Welzel, Thomas; Debus, Juergen; Combs, Stephanie E.

    2011-12-01

    Puropose: To asses early toxicity and response in 118 patients treated with scanned ion beams to validate the safety of intensity-controlled raster scanning at the Heidelberg Ion Therapy Center. Patients and Methods: Between November 2009 and June 2010, we treated 118 patients with proton and carbon ion radiotherapy (RT) using active beam delivery. The main indications included skull base chordomas and chondrosarcomas, salivary gland tumors, and gliomas. We evaluated early toxicity within 6 weeks after RT and the initial clinical and radiologic response for quality assurance in our new facility. Results: In all 118 patients, few side effects were observed, in particular, no high numbers of severe acute toxicity were found. In general, the patients treated with particle therapy alone showed only a few single side effects, mainly Radiation Therapy Oncology Group/Common Terminology Criteria grade 1. The most frequent side effects and cumulative incidence of single side effects were observed in the head-and-neck patients treated with particle therapy as a boost and photon intensity-modulated RT. The toxicities included common radiation-attributed reactions known from photon RT, including mucositis, dysphagia, and skin erythema. The most predominant imaging responses were observed in patients with high-grade gliomas and those with salivary gland tumors. For skull base tumors, imaging showed a stable tumor outline in most patients. Thirteen patients showed improvement of pre-existing clinical symptoms. Conclusions: Side effects related to particle treatment were rare, and the overall tolerability of the treatment was shown. The initial response was promising. The data have confirmed the safe delivery of carbon ions and protons at the newly opened Heidelberg facility.

  2. Multimedia Analysis plus Visual Analytics = Multimedia Analytics

    SciTech Connect

    Chinchor, Nancy; Thomas, James J.; Wong, Pak C.; Christel, Michael; Ribarsky, Martin W.

    2010-10-01

    Multimedia analysis has focused on images, video, and to some extent audio and has made progress in single channels excluding text. Visual analytics has focused on the user interaction with data during the analytic process plus the fundamental mathematics and has continued to treat text as did its precursor, information visualization. The general problem we address in this tutorial is the combining of multimedia analysis and visual analytics to deal with multimedia information gathered from different sources, with different goals or objectives, and containing all media types and combinations in common usage.

  3. The implementation and evaluation of the Emergency Response Dose Assessment System (ERDAS) at Cape Canaveral Air Station/Kennedy Space Center

    SciTech Connect

    Evans, R.J.; Tremback, C.J.; Lyons, W.A.

    1996-12-31

    NASA and the Air Force at Kennedy Space Center/Cape Canaveral Air Station (KSC/CCAS) are attempting to upgrade and improve their capabilities for emergency response dispersion modeling and mesoscale meteorological forecasting. Their goal is to improve short range forecasts (up to 24 hours) for phenomena such as thunderstorms and sea breezes and to more accurately predict toxic diffusion concentrations in case of hazardous spills. To assist NASA and the Air Force in achieving this goal, the Applied Meteorology Unit (AMU) has been evaluating the Emergency Response Dose Assessment System (ERDAS). ERDAS is a prototype software and hardware system configured to produce routine mesoscale meteorological forecasts and enhanced dispersion estimates on an operational basis for the KSC/CCAS region. ERDAS includes two major software systems which is run and accessed through a graphical user interface. The first software system is the Regional Atmospheric Modeling System (RAMS), a three-dimensional, multiple nested grid prognostic mesoscale model. The second software system is the Hybrid Particle and Concentration Transport (HYPACT) model, a pollutant trajectory and concentration model. ERDAS also runs the Rocket Exhaust Effluent Diffusion Model (REEDM). This paper describes the system, the model evaluation, the process of transitioning ERDAS from a research project to an operational system, and also presents the results of the launch case studies.

  4. Analytical psychology and Daoist inner alchemy: a response to C.G. Jung's 'Commentary on The Secret of the Golden Flower'.

    PubMed

    Zhu, Caifang Jeremy

    2009-09-01

    This paper provides a historical, religious-philosophical context for the study of the Daoist text known as The Secret of the Golden Flower. An updated study is conducted into the controversy over the source of the text including the editions translated by Richard Wilhelm and Thomas Cleary. The main teachings of the text and the basics of two major denominations of Daoism are introduced to ground later critiques of Jung's commentary. The psychodynamics of analytical psychology, especially those concerned with integration of unconscious contents and the realization of the self (individuation) are compared with the psycho-spiritual dynamics of integration in Eastern spirituality based on the Golden Flower text. The paper concludes that it was amiss for Jung to have equated the Western 'unconscious' with states of higher consciousness in Eastern meditation practices, although his claim that Eastern higher consciousness is characterized by a nebulous state of non-intentionality does raise questions about the appropriateness of calling Eastern meditative states 'consciousness'. A new concept is required to characterize the special qualities of this psychic state shared generally by Eastern spiritual traditions and a more meaningful comparison may be found in Jung's concept of the self. PMID:19765138

  5. Visual Analytics Science and Technology

    SciTech Connect

    Wong, Pak C.

    2007-03-01

    It is an honor to welcome you to the first theme issue of information visualization (IVS) dedicated entirely to the study of visual analytics. It all started from the establishment of the U.S. Department of Homeland Security (DHS) sponsored National Visualization and Analytics Center™ (NVAC™) at the Pacific Northwest National Laboratory (PNNL) in 2004. In 2005, under the leadership of NVAC, a team of the world’s best and brightest multidisciplinary scholars coauthored its first research and development (R&D) agenda Illuminating the Path, which defines the study as “the science of analytical reasoning facilitated by interactive visual interfaces.” Among the most exciting, challenging, and educational events developed since then was the first IEEE Symposium on Visual Analytics Science and Technology (VAST) held in Baltimore, Maryland in October 2006. This theme issue features seven outstanding articles selected from the IEEE VAST proceedings and a commentary article contributed by Jim Thomas, the director of NVAC, on the status and progress of the center.

  6. Hastings Center

    MedlinePlus

    ... Events October 19, Hastings Center Seminar, Garrison : Human Genetic Engineering: Wh at Can We Do? What Should We ... Events October 19, Hastings Center Seminar, Garrison : Human Genetic Engineering: Wh at Can We Do? What Should We ...

  7. Proposed Construction of the Petaluma Center of Santa Rosa Junior College. A Report to the Governor and Legislature in Response to a Request for Capital Funds for a Permanent Off-Campus Center in Southern Sonoma County.

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    The California Postsecondary Education Commission's (CPEC) analysis of the Sonoma County Junior College District's (SCJCD) proposal to establish a permanent off-campus center in the city of Petaluma is presented in this report. Part I provides background to the proposal, indicating that the SCJCD has operated a temporary center in relocatable…

  8. Analytical Chemistry of Nitric Oxide

    PubMed Central

    Hetrick, Evan M.

    2013-01-01

    Nitric oxide (NO) is the focus of intense research, owing primarily to its wide-ranging biological and physiological actions. A requirement for understanding its origin, activity, and regulation is the need for accurate and precise measurement techniques. Unfortunately, analytical assays for monitoring NO are challenged by NO’s unique chemical and physical properties, including its reactivity, rapid diffusion, and short half-life. Moreover, NO concentrations may span pM to µM in physiological milieu, requiring techniques with wide dynamic response ranges. Despite such challenges, many analytical techniques have emerged for the detection of NO. Herein, we review the most common spectroscopic and electrochemical methods, with special focus on the fundamentals behind each technique and approaches that have been coupled with modern analytical measurement tools or exploited to create novel NO sensors. PMID:20636069

  9. A Survey of Risk Analytics

    NASA Astrophysics Data System (ADS)

    Picoult, Evan

    2003-03-01

    Risk Analytical Units within Wall Street firms are responsible for developing the methods used to quantify the different forms of risk inherent in the firms' activities. This talk is an overview of risk analytics. It will cover: the function and validation of valuation models; the measurement of market risk; and the measurement of the different aspects of and forms of credit risk, including the simulation of the potential counterparty credit exposure of derivatives, the estimation of obligor default probability and the simulation of the potential loss distribution of loan portfolios. Risk Analytics is an applied field that integrates finance theory, mathematics and statistical analysis. It is a field in that has attracted many physicists and one in which many physicists have flourished. The talk will conclude with an analysis of why this is so.

  10. Analytical Challenges in Biotechnology.

    ERIC Educational Resources Information Center

    Glajch, Joseph L.

    1986-01-01

    Highlights five major analytical areas (electrophoresis, immunoassay, chromatographic separations, protein and DNA sequencing, and molecular structures determination) and discusses how analytical chemistry could further improve these techniques and thereby have a major impact on biotechnology. (JN)

  11. Summer-Long Grazing of High vs. Low Endophyte (Neotyphodium coenophialum)-Infected Tall Fescue by Growing Beef Steers Results in Distinct Temporal Blood Analyte Response Patterns, with Poor Correlation to Serum Prolactin Levels

    PubMed Central

    Jackson, Joshua J.; Lindemann, Merlin D.; Boling, James A.; Matthews, James C.

    2015-01-01

    Previously, we reported the effects of fescue toxicosis on developing Angus-cross steer growth, carcass, hepatic mRNA, and protein expression profiles of selected serum proteins, and blood clinical and chemical profiles, after summer-long grazing (85 days) of high endophyte (HE)- vs. low endophyte (LE)-infected fescue pastures. We now report the temporal development of acute, intermediate, and chronic responses of biochemical and clinical blood analytes determined at specified time intervals (period 1, day 0–36; period 2, day 37–58; and period 3, day 59–85). Throughout the trial, the alkaloid concentrations of the HE forage was consistently 19–25 times greater (P ≤ 0.002) than the concentration in the LE forage, and HE vs. LE steers had continuously lower (P ≤ 0.049) serum prolactin (85%), cholesterol (27%), and albumin (5%), but greater red blood cells (7%). The HE steers had decreased (P = 0.003) ADG only during period 1 (−0.05 vs. 0.4 kg/day). For period 1, HE steers had reduced (P ≤ 0.090) numbers of eosinophils (55%) and lymphocytes (18%), serum triglyceride (27%), and an albumin/globulin ratio (9%), but an increased bilirubin concentration (20%). During period 2, serum LDH activities were 18% lower (P = 0.022) for HE vs. LE steers. During period 3, serum levels of ALP (32%), ALT (16%), AST (15%), creatine kinase (35%), glucose (10%), and LDH (23%) were lower (P ≤ 0.040) for HE steers. Correlation analysis of serum prolactin and other blood analytes revealed that triglycerides (P = 0.042) and creatinine (P = 0.021) were moderately correlated (r ≤ 0.433) with HE serum prolactin. In conclusion, three HE-induced blood analyte response patterns were identified: continually altered, initially altered, and subsequently “recovered,” or altered only after long-term exposure. Blood analytes affected by length of grazing HE vs. LE forages were either not or poorly correlated with serum prolactin. These data

  12. Analyticity without Differentiability

    ERIC Educational Resources Information Center

    Kirillova, Evgenia; Spindler, Karlheinz

    2008-01-01

    In this article we derive all salient properties of analytic functions, including the analytic version of the inverse function theorem, using only the most elementary convergence properties of series. Not even the notion of differentiability is required to do so. Instead, analytical arguments are replaced by combinatorial arguments exhibiting…

  13. The transfer of analytical procedures.

    PubMed

    Ermer, J; Limberger, M; Lis, K; Wätzig, H

    2013-11-01

    Analytical method transfers are certainly among the most discussed topics in the GMP regulated sector. However, they are surprisingly little regulated in detail. General information is provided by USP, WHO, and ISPE in particular. Most recently, the EU emphasized the importance of analytical transfer by including it in their draft of the revised GMP Guideline. In this article, an overview and comparison of these guidelines is provided. The key to success for method transfers is the excellent communication between sending and receiving unit. In order to facilitate this communication, procedures, flow charts and checklists for responsibilities, success factors, transfer categories, the transfer plan and report, strategies in case of failed transfers, tables with acceptance limits are provided here, together with a comprehensive glossary. Potential pitfalls are described such that they can be avoided. In order to assure an efficient and sustainable transfer of analytical procedures, a practically relevant and scientifically sound evaluation with corresponding acceptance criteria is crucial. Various strategies and statistical tools such as significance tests, absolute acceptance criteria, and equivalence tests are thoroughly descibed and compared in detail giving examples. Significance tests should be avoided. The success criterion is not statistical significance, but rather analytical relevance. Depending on a risk assessment of the analytical procedure in question, statistical equivalence tests are recommended, because they include both, a practically relevant acceptance limit and a direct control of the statistical risks. However, for lower risk procedures, a simple comparison of the transfer performance parameters to absolute limits is also regarded as sufficient. PMID:23978903

  14. Job center

    NASA Astrophysics Data System (ADS)

    To better meet the needs of AGU members, a program has been started to increase the effectiveness of the Job Center activity at the Spring and Fall Meetings. As a result, participation in the Job Center at the 1988 AGU Spring Meeting in Baltimore increased substantially compared to previous Spring Meetings. The number of employers, applicants, and interviews scheduled more than doubled compared to the 1987 Spring Job Center.In order to make the meeting Job Centers even better, a survey is being conducted of employers and applicants who participated in the 1988 Spring Job Center. Evaluation of this survey will be useful in continuing increased participation in and the effectiveness of the Job Center at the 1988 Fall Meeting. Past participants and those interested in the future of the Job Center are encouraged to forward comments and suggestions to AGU, Member Programs Division, 2000 Florida Ave., N.W., Washington, DC 20009.

  15. Strategies to Improve Glaucoma Compliance Based on Cross-Sectional Response-Based Data in a Tertiary Healthcare Center: The Glauco-Jung Study

    PubMed Central

    Gupta, Vishnu S; Sethi, Harindersingh

    2015-01-01

    ABSTRACT Purpose: To elucidate compliance rates among glaucoma patients in a tertiary healthcare center, reasons for noncompliance and response-based-solutions to improve compl iance in the same cohort. Materials and methods: In the Glauco-Jung study, a cross-sectional descriptive epidemiological one, information was obtained from 500 patients from 1st January, 2014 to 30th June, 2014. Patients were intercepted at entry point where they get their intraocular pressure (IOP) checked, wherein they were asked to fill an exhaustive questionnaire. At the same setting, they were also asked to demonstrate how they (or their relatives or helpers) instill eyedrops, following which any irregularities were brought to notice and corrected. Finally, they were also asked any suggestions to improve compliance to medications. Noncompliance rates were determined based on the number of patients who did not instill anti-glaucoma medications as per prescribed dosage or frequency schedule. Noncompliance rates were then evaluated by the Chi-square test for any association with distributions based on various parameters. Results: In case of a positive association, correlation coefficient was further calculated to know the strength of this association. No association was observed in distributions based on diet, associated co-morbidities, daily dosage frequency and side-effects experienced by patients. Positive association was noted in distributions based on age, sex, duration of treatment, social structure and number of medications (p < 0.05); but correlation coefficients were very weak (c < 0.3). Cost of medications not only had positive association but also had a very strong correlation coefficient (c = 0.9188), proving that cost of medications had a modest bearing on compliance rates. Conclusion: The Glauco-Jung study concluded that besides availability of medications at reasonable cost, simplification of treatment regimen and interactive health education appear to be the most important

  16. Capabilities of the Natural Environments Branch at NASA's Marshall Space Flight Center, Revised 2009

    NASA Technical Reports Server (NTRS)

    Edwards, David L.; Suggs, Rob; Roberts, Barry C.; Cooke, William J.

    2009-01-01

    The Natural Environment Branch at NASA's Marshall Space Flight Center (MSFC) has the responsibility to provide natural environments engineering support to programs and projects. The Natural Environments Branch is responsible for natural environments definitions, modeling, database development, and analytical assessments of effects. Natural Environments Branch personnel develop requirements for flight projects and provide operational support for space and launch vehicle systems. To accomplish these responsibilities, models and analytical tools have been developed in the areas of planetary atmospheres, meteoroids, ionizing radiation, plasmas and ionospheres, magnetic and gravitational fields, spacecraft charging modeling, and radiation effects on electronic parts. This paper will build on a previous paper published in 2006 and provide updated descriptions of the capabilities within the Natural Environments Branch1. Updates describing improvements and new releases of several analytical tools and models will be presented. Separate sections will specifically describe modifications in the Meteoroid Engineering Model (MEM), and the Marshall Solar Activity Future Estimation (MSAFE) capabilities.

  17. Importance of the Chiral Centers of Jasmonic Acid in the Responses of Plants (Activities and Antagonism between Natural and Synthetic Analogs).

    PubMed Central

    Holbrook, L.; Tung, P.; Ward, K.; Reid, D. M.; Abrams, S.; Lamb, N.; Quail, J. W.; Moloney, M. M.

    1997-01-01

    The importance of the two chiral centers at C-3 and C-7 in the molecular structure of jasmonic acid in plant responses was investigated. We separated methyl jasmonate (MeJA) into (3R)- and (3S)-isomers with a fixed stereochemistry at C-3, but epimerization at C-7 is possible. The four isomers of the nonepimerizable analog 7-methyl MeJA were synthesized. These six esters and their corresponding acids were tested in three bioassays: (a) senescence in sunflower (Helianthus annuus) cotyledons; (b) proteinase inhibitor II gene expression in transgenic tobacco (Nicotiana tabacum) with [beta]-glucuronidase as a biochemical reporter; and (c) seed germination in Brassica napus and wheat (Triticum aestivum). The esters and acids had similar activities in the three assays, with the ester being more effective than its acid. The (3R)-stereochemistry was critical for jasmonate activity. Although activity was reduced after substituting the C-7 proton with a methyl group, the analogs with (3R,7R)- or (3R,7S)-stereochemistry were active in some of the assays. Although the four isomers of 7-methyl MeJA were inactive or only weakly active in the senescence assay, they could overcome the senescence-promoting effect of (3R)-MeJA. The strongest antagonistic effect was observed with the (3R,7S)-isomer. PMID:12223716

  18. Clusterin Is a Potential Lymphotoxin Beta Receptor Target That Is Upregulated and Accumulates in Germinal Centers of Mouse Spleen during Immune Response

    PubMed Central

    Afanasyeva, Marina A.; Britanova, Liudmila V.; Korneev, Kirill V.; Mitkin, Nikita A.; Kuchmiy, Anna A.; Kuprash, Dmitry V.

    2014-01-01

    Clusterin is a multifunctional protein that participates in tissue remodeling, apoptosis, lipid transport, complement-mediated cell lysis and serves as an extracellular chaperone. The role of clusterin in cancer and neurodegeneration has been extensively studied, however little is known about its functions in the immune system. Using expression profiling we found that clusterin mRNA is considerably down-regulated in mouse spleen stroma upon knock-out of lymphotoxin β receptor which plays pivotal role in secondary lymphoid organ development, maintenance and function. Using immunohistochemistry and western blot we studied clusterin protein level and distribution in mouse spleen and mesenteric lymph nodes in steady state and upon immunization with sheep red blood cells. We showed that clusterin protein, represented mainly by the secreted heterodimeric form, is present in all stromal compartments of secondary lymphoid organs except for marginal reticular cells. Clusterin protein level rose after immunization and accumulated in light zones of germinal centers in spleen - the effect that was not observed in lymph nodes. Regulation of clusterin expression by the lymphotoxin beta signaling pathway and its protein dynamics during immune response suggest a specific role of this enigmatic protein in the immune system that needs further study. PMID:24865838

  19. Response of climate simulation of a new convective parameterization in the National Center for Atmospheric Research Community Climate Mosel (CCM3)

    SciTech Connect

    Zhang, G.J.; Kiehl, J.T.; Rasch, P.J.

    1998-08-01

    This study examines the response of the climate simulation by the National Center for Atmospheric Research Community Climate Model (CCM3) to the introduction of the Zhang and McFarlane convective parameterization in the model. It is shown that in the CCM3 the simulated surface climate in the tropical convective regimes, especially in the western Pacific warm pool, is markedly improved, yielding a much better agreement with the recent observations. The systematic bias in the surface evaporation, surface wind stress over the tropical Pacific Ocean in previous model simulations is significantly reduced, owing to the better simulation of the surface flow. Experiments using identical initial and boundary conditions, but different convection schemes, are performed to isolate the role of the convection schemes and to understand the interaction between convection and the large-scale circulation in a convecting atmosphere. The comparison of the results from these experiments in the western Pacific warm pool suggests that use of the Zhang and McFarlane scheme makes a significant contribution to the improved climate simulation in CCM3. The simulated atmosphere using the Zhang and McFarlane scheme exhibits a quasi-equilibrium between convection and the large-scale processes. When this scheme is removed from the CCM3, such a quasi-equilibrium is no longer observed. In addition, the simulated thermodynamic structures, the surface evaporation, and surface winds in the Pacific warm pool become very similar to those in the CCM2 climate.

  20. Sensor for detecting and differentiating chemical analytes

    DOEpatents

    Yi, Dechang; Senesac, Lawrence R.; Thundat, Thomas G.

    2011-07-05

    A sensor for detecting and differentiating chemical analytes includes a microscale body having a first end and a second end and a surface between the ends for adsorbing a chemical analyte. The surface includes at least one conductive heating track for heating the chemical analyte and also a conductive response track, which is electrically isolated from the heating track, for producing a thermal response signal from the chemical analyte. The heating track is electrically connected with a voltage source and the response track is electrically connected with a signal recorder. The microscale body is restrained at the first end and the second end and is substantially isolated from its surroundings therebetween, thus having a bridge configuration.

  1. Strained Si-O-Si bonds in amorphous SiO2 materials: A family member of active centers in radio, photo, and chemical responses

    NASA Astrophysics Data System (ADS)

    Awazu, Koichi; Kawazoe, Hiroshi

    2003-11-01

    Amorphous SiO2 (a-SiO2), such as bulk silica glasses and thin films has been one of the key materials in modern optoelectronic industries. These materials are currently used in communication technologies as optical fibers, thin films for electrical insulation in dynamic random access memories (DRAM), and optical lenses for excimer laser lithography, for example. The property essential for these applications is the wide band gap amounting to ˜9 eV. However, bulk silica glasses commercially available and silica thin films show photoresponses to subband gap lights in the vicinity of 5 eV and unexpected trapping of charges, and the behavior has a strong dependency on the preparation history. A number of studies were carried out to clarify the relationship between the properties and structural imperfections in the materials and the formation mechanisms of the defects. There are two categories of the imperfections: one is dopant- or impurity-related imperfections and the other is nonstoichiometry related defects. These defects constitute gap states in a-SiO2. The structural identification was usually performed by absorption and emission spectroscopy in the visible-ultraviolet (UV) region and electron spin resonance (ESR). The experimentally proposed models were compared with the predictions by theoretical calculations of energy levels. Recent development of the excimer laser lithography technique led us to recognize that a latent member, which has been unnoticed because of no response to the optical absorption or emission in the visible-UV range and ESR absorption, exists in the family of active centers in a-SiO2, that is a strained Si-O-Si bond originating from the planar three membered ring. In contrast, the puckered four membered ring is unstrained. Although it has been pointed out that there was a wide distribution in Si-O-Si bond angle from 90° to 180° by x-ray analysis or 29Si solid state nuclear magnetic resonance, the physical, and chemical responses of the Si

  2. Reduced response to chronic mild stress in PACAP mutant mice is associated with blunted FosB expression in limbic forebrain and brainstem centers.

    PubMed

    Kormos, Viktória; Gáspár, László; Kovács, László Á; Farkas, József; Gaszner, Tamás; Csernus, Valér; Balogh, András; Hashimoto, Hitoshi; Reglődi, Dóra; Helyes, Zsuzsanna; Gaszner, Balázs

    2016-08-25

    Pituitary adenylate cyclase-activating polypeptide (PACAP) has been implicated in stress adaptation with potential relevance in mood disorder management. PACAP deficient (KO) mice on CD1 background were shown to have depression-like phenotype. Here we aimed at investigating effects of chronic variable mild stress (CVMS) in non-injected, vehicle and imipramine-treated KO mice vs. wildtype (WT) counterparts. We hypothesized reduced FosB neuronal activity in stress-related centers, altered activity and peptide/neurotransmitter content of corticotropin-releasing factor (CRF) cells of the oval (ovBST) bed nucleus of stria terminalis (BST), urocortin 1 (Ucn1) neurons of centrally projecting Edinger-Westphal nucleus (cpEW) and serotonin (5HT) cells of dorsal raphe (DR) in PACAP deficiency. CVMS caused decreased body weight and increased adrenal size, corticosterone (CORT) titers and depression-like behavior in WT mice, in contrast to KO animals. CVMS increased FosB in the central (CeA) and medial amygdala, dorsomedial (dmBST), ventral (vBST), ovBST, CA1 area, dentate gyrus (DG), ventral lateral septum, parvo- (pPVN) and magnocellular paraventricular nucleus, lateral periaqueductal gray, cpEW and DR. Lack of PACAP blunted the CVMS-induced FosB rise in the CeA, ovBST, dmBST, vBST, CA1 area, pPVN and DR. The CVMS-induced FosB expression in ovBST-CRF and cpEW-Ucn1 neurons was abolished in KO mice. Although CVMS did not induce FosB in 5HT-DR neurons, PACAP KO mice had increased 5HT cell counts and 5HT content. We conclude that PACAP deficiency affects neuronal reactivity in a brain area-specific manner in stress centers, as well as in ovBST-CRF, cpEW-Ucn1 and 5HT-DR neurons leading to reduced CVMS response and altered depression level. PMID:27282087

  3. Science Update: Analytical Chemistry.

    ERIC Educational Resources Information Center

    Worthy, Ward

    1980-01-01

    Briefly discusses new instrumentation in the field of analytical chemistry. Advances in liquid chromatography, photoacoustic spectroscopy, the use of lasers, and mass spectrometry are also discussed. (CS)

  4. Analytical Chemistry in Industry.

    ERIC Educational Resources Information Center

    Kaiser, Mary A.; Ullman, Alan H.

    1988-01-01

    Clarifies the roles of a practicing analytical chemist in industry: quality control, methods and technique development, troubleshooting, research, and chemical analysis. Lists criteria for success in industry. (ML)

  5. Skills Center.

    ERIC Educational Resources Information Center

    Canter, Patricia; And Others

    The services of the Living Skills Center for the Visually Handicapped, a habilitative service for blind young adults, are described. It is explained that the Center houses its participants in their own apartments in a large complex and has served over 70 young people in 4 years. The evaluation section describes such assessment instruments as an…

  6. Emergency Operations Center at Johnson Space Center

    NASA Technical Reports Server (NTRS)

    Caylor, Gary C.

    1997-01-01

    In June 1966, at the start of the Gulf Coast hurricane season, the Johnson Space Center (JSC) celebrated the opening of its new 4,000-square foot, state-of-the-art Emergency Operations Center (EOC). The new EOC has been upgraded and enhanced to support a wide spectrum of emergencies affecting JSC and neighboring communities. One of the main features of the EOC is its premier computerized dispatch center. The new system unites many of JSC's critical emergency functions into one integrated network. It automatically monitors fire alarms, security entrances, and external cameras. It contains the JSC inventory of hazardous materials, by building and room, and can call up Material Safety Data Sheets for most of the generic hazardous materials used on-site. The EOC is available for community use during area emergencies such as hurricanes and is a welcome addition to the Clear Lake/Galveston Bay Area communities' emergency response resources.

  7. Final Environmental Impact Statement for the construction and operation of Claiborne Enrichment Center, Homer, Louisiana (Docket No. 70-3-70). Volume 2, Public comments and NRC response

    SciTech Connect

    Zeitoun, A.

    1994-08-01

    The Final Environmental Impact Statement (FEIS) (Volume 1), was prepared by the Nuclear Regulatory Commission (NRC) in accordance with regulation 10 CFR Part 51, which implements the National Environmental Policy Act (NEPA), to assess the potential environmental impacts for licensing the construction and operation of a proposed gaseous centrifuge enrichment facility to be built in Claiborne Parish, Louisiana by Louisiana Energy Services, L.P. (LES). The proposed facility would have a production capacity of about 866 metric tons annually of up to 5 weight percent enriched UF{sub 6}, using a proven centrifuge technology. Included in the assessment are co on, both normal operations and potential accidents (internal and external events), and the eventual decontamination and decommissioning of the site. In order to help assure that releases from the operation of the facility and potential impacts on the public are as low as reasonably achievable, an environmental monitoring program was developed by LES to detect significant changes in the background levels of uranium around the site. Other issues addressed include the purpose and need for the facility, the alternatives to the proposed action, potential disposition of the tails, the site selection process, and environmental justice. The NRC staff concludes that the facility can be constructed and operated with small and acceptable impacts on the public and the environment, and proposes to issue a license to the applicant, Louisiana Energy Services, to authorize construction and operation of the proposed facility. The letters in this Appendix have been divided into three sections. Section One contains letters to which the NRC responded by addressing specific comments. Section Two contains the letters that concerned the communities of Forest Grove and Center Springs. Section Three is composed of letters that required no response. These letters were generally in support of the facility.

  8. Response

    ERIC Educational Resources Information Center

    Higgins, Chris

    2012-01-01

    This article presents the author's response to the reviews of his book, "The Good Life of Teaching: An Ethics of Professional Practice." He begins by highlighting some of the main concerns of his book. He then offers a brief response, doing his best to address the main criticisms of his argument and noting where the four reviewers (Charlene…

  9. Process Analytical Chemistry.

    ERIC Educational Resources Information Center

    Callis, James B.; And Others

    1987-01-01

    Discusses process analytical chemistry as a discipline designed to supply quantitative and qualitative information about a chemical process. Encourages academic institutions to examine this field for employment opportunities for students. Describes the five areas of process analytical chemistry, including off-line, at-line, on-line, in-line, and…

  10. Extreme Scale Visual Analytics

    SciTech Connect

    Wong, Pak C.; Shen, Han-Wei; Pascucci, Valerio

    2012-05-08

    Extreme-scale visual analytics (VA) is about applying VA to extreme-scale data. The articles in this special issue examine advances related to extreme-scale VA problems, their analytical and computational challenges, and their real-world applications.

  11. Learning Analytics Considered Harmful

    ERIC Educational Resources Information Center

    Dringus, Laurie P.

    2012-01-01

    This essay is written to present a prospective stance on how learning analytics, as a core evaluative approach, must help instructors uncover the important trends and evidence of quality learner data in the online course. A critique is presented of strategic and tactical issues of learning analytics. The approach to the critique is taken through…

  12. Analytical mass spectrometry

    SciTech Connect

    Not Available

    1990-01-01

    This 43rd Annual Summer Symposium on Analytical Chemistry was held July 24--27, 1990 at Oak Ridge, TN and contained sessions on the following topics: Fundamentals of Analytical Mass Spectrometry (MS), MS in the National Laboratories, Lasers and Fourier Transform Methods, Future of MS, New Ionization and LC/MS Methods, and an extra session. (WET)

  13. Analytical mass spectrometry. Abstracts

    SciTech Connect

    Not Available

    1990-12-31

    This 43rd Annual Summer Symposium on Analytical Chemistry was held July 24--27, 1990 at Oak Ridge, TN and contained sessions on the following topics: Fundamentals of Analytical Mass Spectrometry (MS), MS in the National Laboratories, Lasers and Fourier Transform Methods, Future of MS, New Ionization and LC/MS Methods, and an extra session. (WET)

  14. Validating Analytical Methods

    ERIC Educational Resources Information Center

    Ember, Lois R.

    1977-01-01

    The procedures utilized by the Association of Official Analytical Chemists (AOAC) to develop, evaluate, and validate analytical methods for the analysis of chemical pollutants are detailed. Methods validated by AOAC are used by the EPA and FDA in their enforcement programs and are granted preferential treatment by the courts. (BT)

  15. Teaching the Analytical Life

    ERIC Educational Resources Information Center

    Jackson, Brian

    2010-01-01

    Using a survey of 138 writing programs, I argue that we must be more explicit about what we think students should get out of analysis to make it more likely that students will transfer their analytical skills to different settings. To ensure our students take analytical skills with them at the end of the semester, we must simplify the task we…

  16. Signals: Applying Academic Analytics

    ERIC Educational Resources Information Center

    Arnold, Kimberly E.

    2010-01-01

    Academic analytics helps address the public's desire for institutional accountability with regard to student success, given the widespread concern over the cost of higher education and the difficult economic and budgetary conditions prevailing worldwide. Purdue University's Signals project applies the principles of analytics widely used in…

  17. Senior Centers

    MedlinePlus Videos and Cool Tools

    ... something many older adults would like to do as long as they can. Senior centers, adult day care, transportation, ... adults who live independently can go to find a variety of social and recreational activities. [Karen Albers] ...

  18. Analytical prediction of aerospace vehicle vibration environments

    NASA Technical Reports Server (NTRS)

    Wilby, J. F.; Piersol, A. G.

    1981-01-01

    Considerable attention has been given recently to the formulation and validation of analytical models for the prediction of aerospace vehicle vibration response to acoustic and fluctuating pressures. This paper summarizes the development of such analytical models for two applications, (1) structural vibrations of the Space Shuttle orbiter vehicle due to broadband rocket noise and aerodynamic boundary layer turbulence, and (2) structural vibrations of general aviation aircraft due to discrete frequency propeller and reciprocating engine exhaust noise. In both cases, the spatial exterior excitations are convected pressure fields which are described on the basis of measured cross spectra (coherence and phase) information. Structural modal data are obtained from analytical predictions, and structural responses to appropriate excitation fields are calculated. The results are compared with test data, and the strengths and weaknesses of the analytical models are assessed.

  19. Analytical prediction of aerospace vehicle vibration environments

    NASA Astrophysics Data System (ADS)

    Wilby, J. F.; Piersol, A. G.

    1981-09-01

    Considerable attention has been given recently to the formulation and validation of analytical models for the prediction of aerospace vehicle vibration response to acoustic and fluctuating pressures. This paper summarizes the development of such analytical models for two applications, (1) structural vibrations of the Space Shuttle orbiter vehicle due to broadband rocket noise and aerodynamic boundary layer turbulence, and (2) structural vibrations of general aviation aircraft due to discrete frequency propeller and reciprocating engine exhaust noise. In both cases, the spatial exterior excitations are convected pressure fields which are described on the basis of measured cross spectra (coherence and phase) information. Structural modal data are obtained from analytical predictions, and structural responses to appropriate excitation fields are calculated. The results are compared with test data, and the strengths and weaknesses of the analytical models are assessed.

  20. Analytical Ultrasonics in Materials Research and Testing

    NASA Technical Reports Server (NTRS)

    Vary, A.

    1986-01-01

    Research results in analytical ultrasonics for characterizing structural materials from metals and ceramics to composites are presented. General topics covered by the conference included: status and advances in analytical ultrasonics for characterizing material microstructures and mechanical properties; status and prospects for ultrasonic measurements of microdamage, degradation, and underlying morphological factors; status and problems in precision measurements of frequency-dependent velocity and attenuation for materials analysis; procedures and requirements for automated, digital signal acquisition, processing, analysis, and interpretation; incentives for analytical ultrasonics in materials research and materials processing, testing, and inspection; and examples of progress in ultrasonics for interrelating microstructure, mechanical properites, and dynamic response.

  1. NMA Analysis Center

    NASA Technical Reports Server (NTRS)

    Kierulf, Halfdan Pascal; Andersen, Per Helge

    2013-01-01

    The Norwegian Mapping Authority (NMA) has during the last few years had a close cooperation with Norwegian Defence Research Establishment (FFI) in the analysis of space geodetic data using the GEOSAT software. In 2012 NMA has taken over the full responsibility for the GEOSAT software. This implies that FFI stopped being an IVS Associate Analysis Center in 2012. NMA has been an IVS Associate Analysis Center since 28 October 2010. NMA's contributions to the IVS as an Analysis Centers focus primarily on routine production of session-by-session unconstrained and consistent normal equations by GEOSAT as input to the IVS combined solution. After the recent improvements, we expect that VLBI results produced with GEOSAT will be consistent with results from the other VLBI Analysis Centers to a satisfactory level.

  2. Enzymes in Analytical Chemistry.

    ERIC Educational Resources Information Center

    Fishman, Myer M.

    1980-01-01

    Presents tabular information concerning recent research in the field of enzymes in analytic chemistry, with methods, substrate or reaction catalyzed, assay, comments and references listed. The table refers to 128 references. Also listed are 13 general citations. (CS)

  3. Analytical techniques: A compilation

    NASA Technical Reports Server (NTRS)

    1975-01-01

    A compilation, containing articles on a number of analytical techniques for quality control engineers and laboratory workers, is presented. Data cover techniques for testing electronic, mechanical, and optical systems, nondestructive testing techniques, and gas analysis techniques.

  4. Extreme Scale Visual Analytics

    SciTech Connect

    Steed, Chad A; Potok, Thomas E; Pullum, Laura L; Ramanathan, Arvind; Shipman, Galen M; Thornton, Peter E

    2013-01-01

    Given the scale and complexity of today s data, visual analytics is rapidly becoming a necessity rather than an option for comprehensive exploratory analysis. In this paper, we provide an overview of three applications of visual analytics for addressing the challenges of analyzing climate, text streams, and biosurveilance data. These systems feature varying levels of interaction and high performance computing technology integration to permit exploratory analysis of large and complex data of global significance.

  5. Analytical Chemistry Laboratory (ACL) procedure compendium. Volume 1, Administrative

    SciTech Connect

    Not Available

    1992-06-01

    Covered are: analytical laboratory operations (ALO) sample receipt and control, ALO data report/package preparation review and control, single shell tank (PST) project sample tracking system, sample receiving, analytical balances, duties and responsibilities of sample custodian, sample refrigerator temperature monitoring, security, assignment of staff responsibilities, sample storage, data reporting, and general requirements for glassware.

  6. Cost and schedule analytical techniques development

    NASA Technical Reports Server (NTRS)

    1994-01-01

    This contract provided technical services and products to the Marshall Space Flight Center's Engineering Cost Office (PP03) and the Program Plans and Requirements Office (PP02) for the period of 3 Aug. 1991 - 30 Nov. 1994. Accomplishments summarized cover the REDSTAR data base, NASCOM hard copy data base, NASCOM automated data base, NASCOM cost model, complexity generators, program planning, schedules, NASA computer connectivity, other analytical techniques, and special project support.

  7. Ocean Pollution Research Center

    SciTech Connect

    Not Available

    1994-10-01

    The Ocean Pollution Research Center (OPRC) is a University of Miami center based at the Rosenstiel School of Marine and Atmospheric Science (RSMAS) and with significant involvement by the College of Engineering. It was formed in 1992 out of concerns for potential oil spills placing at risk the fragile ecosystems of the Florida Keys. OPRC's scope also includes the Caribbean Sea, Gulf of Mexico, and the South Atlantic Bight. Focus is on the physical transport of oil spills and information management for response operations. Studies of the fates and effects of oil spills are also undertaken.

  8. Launch Vehicle Control Center Architectures

    NASA Technical Reports Server (NTRS)

    Watson, Michael D.; Epps, Amy; Woodruff, Van; Vachon, Michael Jacob; Monreal, Julio; Williams, Randall; McLaughlin, Tom

    2014-01-01

    This analysis is a survey of control center architectures of the NASA Space Launch System (SLS), United Launch Alliance (ULA) Atlas V and Delta IV, and the European Space Agency (ESA) Ariane 5. Each of these control center architectures have similarities in basic structure, and differences in functional distribution of responsibilities for the phases of operations: (a) Launch vehicles in the international community vary greatly in configuration and process; (b) Each launch site has a unique processing flow based on the specific configurations; (c) Launch and flight operations are managed through a set of control centers associated with each launch site, however the flight operations may be a different control center than the launch center; and (d) The engineering support centers are primarily located at the design center with a small engineering support team at the launch site.

  9. DNA detection using origami paper analytical devices

    PubMed Central

    Ellington, Andrew D.; Crooks, Richard M.

    2013-01-01

    We demonstrate the hybridization-induced fluorescence detection of DNA on an origami-based paper analytical device (oPAD). The paper substrate was patterned by wax printing and controlled heating to construct hydrophilic channels and hydrophobic barriers in a three-dimensional fashion. A competitive assay was developed where the analyte, a single-stranded DNA (ssDNA), and a quencher-labeled ssDNA competed for hybridization with a fluorophore-labeled ssDNA probe. Upon hybridization of the analyte with the fluorophore-labeled ssDNA, a linear response of fluorescence vs. analyte concentration was observed with an extrapolated limit of detection < 5 nM and a sensitivity relative standard deviation as low as 3%. The oPAD setup was also tested against OR/AND logic gates, proving to be successful in both detection systems. PMID:24070108

  10. DNA detection using origami paper analytical devices.

    PubMed

    Scida, Karen; Li, Bingling; Ellington, Andrew D; Crooks, Richard M

    2013-10-15

    We demonstrate the hybridization-induced fluorescence detection of DNA on an origami-based paper analytical device (oPAD). The paper substrate was patterned by wax printing and controlled heating to construct hydrophilic channels and hydrophobic barriers in a three-dimensional fashion. A competitive assay was developed where the analyte, a single-stranded DNA (ssDNA), and a quencher-labeled ssDNA competed for hybridization with a fluorophore-labeled ssDNA probe. Upon hybridization of the analyte with the fluorophore-labeled ssDNA, a linear response of fluorescence vs analyte concentration was observed with an extrapolated limit of detection <5 nM and a sensitivity relative standard deviation as low as 3%. The oPAD setup was also tested against OR/AND logic gates, proving to be successful in both detection systems. PMID:24070108

  11. Advances in analytical chemistry

    NASA Technical Reports Server (NTRS)

    Arendale, W. F.; Congo, Richard T.; Nielsen, Bruce J.

    1991-01-01

    Implementation of computer programs based on multivariate statistical algorithms makes possible obtaining reliable information from long data vectors that contain large amounts of extraneous information, for example, noise and/or analytes that we do not wish to control. Three examples are described. Each of these applications requires the use of techniques characteristic of modern analytical chemistry. The first example, using a quantitative or analytical model, describes the determination of the acid dissociation constant for 2,2'-pyridyl thiophene using archived data. The second example describes an investigation to determine the active biocidal species of iodine in aqueous solutions. The third example is taken from a research program directed toward advanced fiber-optic chemical sensors. The second and third examples require heuristic or empirical models.

  12. Practical, Ethical, and Legal Considerations regarding Videocounseling in College and University Counseling Centers: A Response to Quarto's "Influencing College Students' Perceptions of Videocounseling"

    ERIC Educational Resources Information Center

    Menzano, Silvestro; Goodwin, Alan; Rockett, Geraldine; Morris, Kathy

    2011-01-01

    There are numerous factors and concerns to take into consideration when implementing new technology into a counseling center's practice. These factors--informed consent, confidentiality, record-keeping, licensure, technical issues, eligibility, emergencies, and staff perceptions--are legitimate and must be addressed and resolved before…

  13. A Phenomenological Perspective of Educating Students at the Matt Garcia Learning Center: Resiliency Development, Responsibility Development and Relationship Building Development Skills

    ERIC Educational Resources Information Center

    Martinez, Robert Anthony

    2013-01-01

    The professional educators of Matt Garcia Learning Center (MGLC) have undertaken a monumental task of providing education to students considered to be significantly at-risk in a public school of choice. These educators are focusing on quelling the "negative success trajectory" prevalent for each of the students of MGLC. Understanding the…

  14. Person-Centered Transition Planning.

    ERIC Educational Resources Information Center

    Miner, Craig A.; Bates, Paul E.

    1997-01-01

    Describes a person-centered planning approach for involving students with disabilities and their families in the transition planning process. Components of person-centered planning are discussed, including development of a personal profile, identification of future lifestyle preferences, action steps and responsible parties, and necessary changes…

  15. Children's cancer centers

    MedlinePlus

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... from getting the care your child needs. The Pediatric Oncology Resource Center has links and contact information ...

  16. Frontiers in analytical chemistry

    SciTech Connect

    Amato, I.

    1988-12-15

    Doing more with less was the modus operandi of R. Buckminster Fuller, the late science genius, and inventor of such things as the geodesic dome. In late September, chemists described their own version of this maxim--learning more chemistry from less material and in less time--in a symposium titled Frontiers in Analytical Chemistry at the 196th National Meeting of the American Chemical Society in Los Angeles. Symposium organizer Allen J. Bard of the University of Texas at Austin assembled six speakers, himself among them, to survey pretty widely different areas of analytical chemistry.

  17. Analytical and experimental study of vibrations in a gear transmission

    NASA Technical Reports Server (NTRS)

    Choy, F. K.; Ruan, Y. F.; Zakrajsek, J. J.; Oswald, Fred B.; Coy, J. J.

    1991-01-01

    An analytical simulation of the dynamics of a gear transmission system is presented and compared to experimental results from a gear noise test rig at the NASA Lewis Research Center. The analytical procedure developed couples the dynamic behaviors of the rotor-bearing-gear system with the response of the gearbox structure. The modal synthesis method is used in solving the overall dynamics of the system. Locally each rotor-gear stage is modeled as an individual rotor-bearing system using the matrix transfer technique. The dynamics of each individual rotor are coupled with other rotor stages through the nonlinear gear mesh forces and with the gearbox structure through bearing support systems. The modal characteristics of the gearbox structure are evaluated using the finite element procedure. A variable time steping integration routine is used to calculate the overall time transient behavior of the system in modal coordinates. The global dynamic behavior of the system is expressed in a generalized coordinate system. Transient and steady state vibrations of the gearbox system are presented in the time and frequency domains. The vibration characteristics of a simple single mesh gear noise test rig is modeled. The numerical simulations are compared to experimental data measured under typical operating conditions. The comparison of system natural frequencies, peak vibration amplitudes, and gear mesh frequencies are generally in good agreement.

  18. Analytical Chemistry Laboratory progress report for FY 1991

    SciTech Connect

    Green, D.W.; Heinrich, R.R.; Graczyk, D.G.; Lindahl, P.C.; Boparai, A.S.

    1991-12-01

    The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year 1991 (October 1990 through September 1991). This is the eighth annual report for the ACL. The Analytical Chemistry Laboratory is a full-cost-recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. In addition, the ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems, from routine standard analyses to unique problems that require significant development of methods and techniques.

  19. Analytical Chemistry Laboratory: Progress report for FY 1988

    SciTech Connect

    Green, D.W.; Heinrich, R.R.; Graczyk, D.G.; Lindahl, P.C.; Erickson, M.D.

    1988-12-01

    The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for fiscal year 1988 (October 1987 through September 1988). The Analytical Chemistry Laboratory is a full-cost recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. In addition, the ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems, from routine standard analyses to unique problems that require significant development of methods and techniques.

  20. Analytical Services Management System

    SciTech Connect

    Church, Shane; Nigbor, Mike; Hillman, Daniel

    2005-03-30

    Analytical Services Management System (ASMS) provides sample management services. Sample management includes sample planning for analytical requests, sample tracking for shipping and receiving by the laboratory, receipt of the analytical data deliverable, processing the deliverable and payment of the laboratory conducting the analyses. ASMS is a web based application that provides the ability to manage these activities at multiple locations for different customers. ASMS provides for the assignment of single to multiple samples for standard chemical and radiochemical analyses. ASMS is a flexible system which allows the users to request analyses by line item code. Line item codes are selected based on the Basic Ordering Agreement (BOA) format for contracting with participating laboratories. ASMS also allows contracting with non-BOA laboratories using a similar line item code contracting format for their services. ASMS allows sample and analysis tracking from sample planning and collection in the field through sample shipment, laboratory sample receipt, laboratory analysis and submittal of the requested analyses, electronic data transfer, and payment of the laboratories for the completed analyses. The software when in operation contains business sensitive material that is used as a principal portion of the Kaiser Analytical Management Services business model. The software version provided is the most recent version, however the copy of the application does not contain business sensitive data from the associated Oracle tables such as contract information or price per line item code.

  1. Analytical Chemistry Laboratory

    NASA Technical Reports Server (NTRS)

    Anderson, Mark

    2013-01-01

    The Analytical Chemistry and Material Development Group maintains a capability in chemical analysis, materials R&D failure analysis and contamination control. The uniquely qualified staff and facility support the needs of flight projects, science instrument development and various technical tasks, as well as Cal Tech.

  2. Analytical Services Management System

    Energy Science and Technology Software Center (ESTSC)

    2005-03-30

    Analytical Services Management System (ASMS) provides sample management services. Sample management includes sample planning for analytical requests, sample tracking for shipping and receiving by the laboratory, receipt of the analytical data deliverable, processing the deliverable and payment of the laboratory conducting the analyses. ASMS is a web based application that provides the ability to manage these activities at multiple locations for different customers. ASMS provides for the assignment of single to multiple samples for standardmore » chemical and radiochemical analyses. ASMS is a flexible system which allows the users to request analyses by line item code. Line item codes are selected based on the Basic Ordering Agreement (BOA) format for contracting with participating laboratories. ASMS also allows contracting with non-BOA laboratories using a similar line item code contracting format for their services. ASMS allows sample and analysis tracking from sample planning and collection in the field through sample shipment, laboratory sample receipt, laboratory analysis and submittal of the requested analyses, electronic data transfer, and payment of the laboratories for the completed analyses. The software when in operation contains business sensitive material that is used as a principal portion of the Kaiser Analytical Management Services business model. The software version provided is the most recent version, however the copy of the application does not contain business sensitive data from the associated Oracle tables such as contract information or price per line item code.« less

  3. Analytics: Changing the Conversation

    ERIC Educational Resources Information Center

    Oblinger, Diana G.

    2013-01-01

    In this third and concluding discussion on analytics, the author notes that we live in an information culture. We are accustomed to having information instantly available and accessible, along with feedback and recommendations. We want to know what people think and like (or dislike). We want to know how we compare with "others like me."…

  4. Social Learning Analytics

    ERIC Educational Resources Information Center

    Buckingham Shum, Simon; Ferguson, Rebecca

    2012-01-01

    We propose that the design and implementation of effective "Social Learning Analytics (SLA)" present significant challenges and opportunities for both research and enterprise, in three important respects. The first is that the learning landscape is extraordinarily turbulent at present, in no small part due to technological drivers. Online social…

  5. Challenges for Visual Analytics

    SciTech Connect

    Thomas, James J.; Kielman, Joseph

    2009-09-23

    Visual analytics has seen unprecedented growth in its first five years of mainstream existence. Great progress has been made in a short time, yet great challenges must be met in the next decade to provide new technologies that will be widely accepted by societies throughout the world. This paper sets the stage for some of those challenges in an effort to provide the stimulus for the research, both basic and applied, to address and exceed the envisioned potential for visual analytics technologies. We start with a brief summary of the initial challenges, followed by a discussion of the initial driving domains and applications, as well as additional applications and domains that have been a part of recent rapid expansion of visual analytics usage. We look at the common characteristics of several tools illustrating emerging visual analytics technologies, and conclude with the top ten challenges for the field of study. We encourage feedback and collaborative participation by members of the research community, the wide array of user communities, and private industry.

  6. Ada & the Analytical Engine.

    ERIC Educational Resources Information Center

    Freeman, Elisabeth

    1996-01-01

    Presents a brief history of Ada Byron King, Countess of Lovelace, focusing on her primary role in the development of the Analytical Engine--the world's first computer. Describes the Ada Project (TAP), a centralized World Wide Web site that serves as a clearinghouse for information related to women in computing, and provides a Web address for…

  7. Analytical Instrument Obsolescence Examined.

    ERIC Educational Resources Information Center

    Haggin, Joseph

    1982-01-01

    The threat of instrument obsolescence and tight federal budgets have conspired to threaten the existence of research analytical laboratories. Despite these and other handicaps most existing laboratories expect to keep operating in support of basic research, though there may be serious penalties in the future unless funds are forthcoming. (Author)

  8. Integrating Carbon Flux Measurements with Hydrologic and Thermal Responses in a Low Centered Ice-Wedge Polygon near Prudhoe Bay, AK

    NASA Astrophysics Data System (ADS)

    Larson, T.; Young, M.; Caldwell, T. G.; Abolt, C.

    2014-12-01

    Substantial attention is being devoted to soil organic carbon (SOC) dynamics in Polar Regions, given the potential impacts of CO2 and methane (CH4) release into the atmosphere. In this study, which is part of a broader effort to quantify carbon loss pathways in patterned Arctic permafrost soils, CH4 and CO2 flux measurements were recorded from a site approximately 30 km south of Deadhorse, Alaska and 1 km west of the Dalton Highway. Samples were collected in late July, 2014 using six static flux chambers that were located within a single low-centered ice-wedge polygon. Three flux chambers were co-located (within a 1 m triangle of each other) near the center of the polygon and three were co-located (along a 1.5 m line) on the ridge adjacent to a trough. Soil in the center of the polygon was 100% water saturated, whereas water saturation measured on the ridge ranged between 25-50%. Depth to ice table was approximately 50 cm near the center of the polygon and 40 cm at the ridge. Temperature depth probes were installed within the center and ridge of the polygon. Nine gas measurements were collected from each chamber over a 24 h period, stored in helium-purged Exetainer vials, shipped to a laboratory, and analyzed using gas chromatography. Measured cumulative methane fluxes were linear over the 24 h period demonstrating constant methane production, but considerable spatial variability in flux was observed (0.1 to 4.7 mg hr-1 m-2 in polygon center, and 0.003 to 0.36 mg hr-1m-2 on polygon ridge). Shallow soil temperatures varied between 1.3 and 9.8oC in the center and 0.6 to 7.5oC in the rim of the polygon. Air temperatures varied between 1.3 and 4.6oC. CO2 fluxes were greater than methane fluxes and more consistent at each co-location; ranging from 21.7 to 36.6 mg hr-1 m-2 near the polygon centers and 3.5 to 29.1 mg hr-1 m-2 in the drier polygon ridge. Results are consistent with previous observations that methanogenesis is favored in a water saturated active layer. The

  9. National Health Information Center

    MedlinePlus

    ... About ODPHP National Health Information Center National Health Information Center The National Health Information Center (NHIC) is ... of interest View the NHO calendar . Federal Health Information Centers and Clearinghouses Federal Health Information Centers and ...

  10. Analytical caustic surfaces

    NASA Technical Reports Server (NTRS)

    Schmidt, R. F.

    1987-01-01

    This document discusses the determination of caustic surfaces in terms of rays, reflectors, and wavefronts. Analytical caustics are obtained as a family of lines, a set of points, and several types of equations for geometries encountered in optics and microwave applications. Standard methods of differential geometry are applied under different approaches: directly to reflector surfaces, and alternatively, to wavefronts, to obtain analytical caustics of two sheets or branches. Gauss/Seidel aberrations are introduced into the wavefront approach, forcing the retention of all three coefficients of both the first- and the second-fundamental forms of differential geometry. An existing method for obtaining caustic surfaces through exploitation of the singularities in flux density is examined, and several constant-intensity contour maps are developed using only the intrinsic Gaussian, mean, and normal curvatures of the reflector. Numerous references are provided for extending the material of the present document to the morphologies of caustics and their associated diffraction patterns.

  11. Requirements for Predictive Analytics

    SciTech Connect

    Troy Hiltbrand

    2012-03-01

    It is important to have a clear understanding of how traditional Business Intelligence (BI) and analytics are different and how they fit together in optimizing organizational decision making. With tradition BI, activities are focused primarily on providing context to enhance a known set of information through aggregation, data cleansing and delivery mechanisms. As these organizations mature their BI ecosystems, they achieve a clearer picture of the key performance indicators signaling the relative health of their operations. Organizations that embark on activities surrounding predictive analytics and data mining go beyond simply presenting the data in a manner that will allow decisions makers to have a complete context around the information. These organizations generate models based on known information and then apply other organizational data against these models to reveal unknown information.

  12. Nuclear analytical chemistry

    SciTech Connect

    Brune, D.; Forkman, B.; Persson, B.

    1984-01-01

    This book covers the general theories and techniques of nuclear chemical analysis, directed at applications in analytical chemistry, nuclear medicine, radiophysics, agriculture, environmental sciences, geological exploration, industrial process control, etc. The main principles of nuclear physics and nuclear detection on which the analysis is based are briefly outlined. An attempt is made to emphasise the fundamentals of activation analysis, detection and activation methods, as well as their applications. The book provides guidance in analytical chemistry, agriculture, environmental and biomedical sciences, etc. The contents include: the nuclear periodic system; nuclear decay; nuclear reactions; nuclear radiation sources; interaction of radiation with matter; principles of radiation detectors; nuclear electronics; statistical methods and spectral analysis; methods of radiation detection; neutron activation analysis; charged particle activation analysis; photon activation analysis; sample preparation and chemical separation; nuclear chemical analysis in biological and medical research; the use of nuclear chemical analysis in the field of criminology; nuclear chemical analysis in environmental sciences, geology and mineral exploration; and radiation protection.

  13. Analytic holographic superconductor

    NASA Astrophysics Data System (ADS)

    Herzog, Christopher P.

    2010-06-01

    We investigate a holographic superconductor that admits an analytic treatment near the phase transition. In the dual 3+1-dimensional field theory, the phase transition occurs when a scalar operator of scaling dimension two gets a vacuum expectation value. We calculate current-current correlation functions along with the speed of second sound near the critical temperature. We also make some remarks about critical exponents. An analytic treatment is possible because an underlying Heun equation describing the zero mode of the phase transition has a polynomial solution. Amusingly, the treatment here may generalize for an order parameter with any integer spin, and we propose a Lagrangian for a spin-two holographic superconductor.

  14. Avatars in Analytical Gaming

    SciTech Connect

    Cowell, Andrew J.; Cowell, Amanda K.

    2009-08-29

    This paper discusses the design and use of anthropomorphic computer characters as nonplayer characters (NPC’s) within analytical games. These new environments allow avatars to play a central role in supporting training and education goals instead of planning the supporting cast role. This new ‘science’ of gaming, driven by high-powered but inexpensive computers, dedicated graphics processors and realistic game engines, enables game developers to create learning and training opportunities on par with expensive real-world training scenarios. However, there needs to be care and attention placed on how avatars are represented and thus perceived. A taxonomy of non-verbal behavior is presented and its application to analytical gaming discussed.

  15. Competing on analytics.

    PubMed

    Davenport, Thomas H

    2006-01-01

    We all know the power of the killer app. It's not just a support tool; it's a strategic weapon. Companies questing for killer apps generally focus all their firepower on the one area that promises to create the greatest competitive advantage. But a new breed of organization has upped the stakes: Amazon, Harrah's, Capital One, and the Boston Red Sox have all dominated their fields by deploying industrial-strength analytics across a wide variety of activities. At a time when firms in many industries offer similar products and use comparable technologies, business processes are among the few remaining points of differentiation--and analytics competitors wring every last drop of value from those processes. Employees hired for their expertise with numbers or trained to recognize their importance are armed with the best evidence and the best quantitative tools. As a result, they make the best decisions. In companies that compete on analytics, senior executives make it clear--from the top down--that analytics is central to strategy. Such organizations launch multiple initiatives involving complex data and statistical analysis, and quantitative activity is managed atthe enterprise (not departmental) level. In this article, professor Thomas H. Davenport lays out the characteristics and practices of these statistical masters and describes some of the very substantial changes other companies must undergo in order to compete on quantitative turf. As one would expect, the transformation requires a significant investment in technology, the accumulation of massive stores of data, and the formulation of company-wide strategies for managing the data. But, at least as important, it also requires executives' vocal, unswerving commitment and willingness to change the way employees think, work, and are treated. PMID:16447373

  16. Industrial Analytics Corporation

    SciTech Connect

    Industrial Analytics Corporation

    2004-01-30

    The lost foam casting process is sensitive to the properties of the EPS patterns used for the casting operation. In this project Industrial Analytics Corporation (IAC) has developed a new low voltage x-ray instrument for x-ray radiography of very low mass EPS patterns. IAC has also developed a transmitted visible light method for characterizing the properties of EPS patterns. The systems developed are also applicable to other low density materials including graphite foams.

  17. Competing on talent analytics.

    PubMed

    Davenport, Thomas H; Harris, Jeanne; Shapiro, Jeremy

    2010-10-01

    Do investments in your employees actually affect workforce performance? Who are your top performers? How can you empower and motivate other employees to excel? Leading-edge companies such as Google, Best Buy, Procter & Gamble, and Sysco use sophisticated data-collection technology and analysis to answer these questions, leveraging a range of analytics to improve the way they attract and retain talent, connect their employee data to business performance, differentiate themselves from competitors, and more. The authors present the six key ways in which companies track, analyze, and use data about their people-ranging from a simple baseline of metrics to monitor the organization's overall health to custom modeling for predicting future head count depending on various "what if" scenarios. They go on to show that companies competing on talent analytics manage data and technology at an enterprise level, support what analytical leaders do, choose realistic targets for analysis, and hire analysts with strong interpersonal skills as well as broad expertise. PMID:20929194

  18. Analytical and simulator study of advanced transport

    NASA Technical Reports Server (NTRS)

    Levison, W. H.; Rickard, W. W.

    1982-01-01

    An analytic methodology, based on the optimal-control pilot model, was demonstrated for assessing longitidunal-axis handling qualities of transport aircraft in final approach. Calibration of the methodology is largely in terms of closed-loop performance requirements, rather than specific vehicle response characteristics, and is based on a combination of published criteria, pilot preferences, physical limitations, and engineering judgment. Six longitudinal-axis approach configurations were studied covering a range of handling qualities problems, including the presence of flexible aircraft modes. The analytical procedure was used to obtain predictions of Cooper-Harper ratings, a solar quadratic performance index, and rms excursions of important system variables.

  19. Report of the Cent Gardes HIV Vaccines Conference. Part 1: The antibody response; Fondation Mérieux Conference Center, Veyrier-du-Lac, France, 25-27 October 2015.

    PubMed

    Girard, Marc P; Le-Grand, Roger; Picot, Valentina; Longuet, Christophe; Nabel, Gary J

    2016-06-30

    The 2015 Cent Gardes Conference on HIV vaccines took place on October 25-27 at the Merieux Foundation Conference Center in Veyrier du Lac, near Annecy, France. The meeting reviewed progress in the development of HIV vaccines and identified new directions of future research. The field has advanced incrementally over the past year but major progress will require additional information from new clinical trials. In this article, we review the presentations on humoral immune responses to HIV, and highlight the difficulty of eliciting broadly neutralizing antibodies by vaccination. Advances in cellular immunity for HIV prevention will be reviewed separately, in a following article. PMID:27216761

  20. Changes produced by bound tryptophan in the ribosome peptidyl transferase center in response to TnaC, a nascent leader peptide.

    PubMed

    Cruz-Vera, Luis Rogelio; Gong, Ming; Yanofsky, Charles

    2006-03-01

    Studies in vitro have established that free tryptophan induces tna operon expression by binding to the ribosome that has just completed synthesis of TnaC-tRNA(Pro), the peptidyl-tRNA precursor of the leader peptide of this operon. Tryptophan acts by inhibiting Release Factor 2-mediated cleavage of this peptidyl-tRNA at the tnaC stop codon. Here we analyze the ribosomal location of free tryptophan, the changes it produces in the ribosome, and the role of the nascent TnaC-tRNA(Pro) peptide in facilitating tryptophan binding and induction. The positional changes of 23S rRNA nucleotides that occur during induction were detected by using methylation protection and binding/competition assays. The ribosome-TnaC-tRNA(Pro) complexes analyzed were formed in vitro; they contained either wild-type TnaC-tRNA(Pro) or its nonfunctional substitute, TnaC(W12R)-tRNA(Pro). Upon comparing these two peptidyl-tRNA-ribosome complexes, free tryptophan was found to block methylation of nucleotide A2572 of wild-type ribosome-TnaC-tRNA(Pro) complexes but not of ribosome-TnaC(W12R)-tRNA(Pro) complexes. Nucleotide A2572 is in the ribosomal peptidyl transferase center. Tryptophanol, a noninducing competitor of tryptophan, was ineffective in blocking A2572 methylation; however, it did reverse the protective effect of tryptophan. Free tryptophan inhibited puromycin cleavage of TnaC-tRNA(Pro); it also inhibited binding of the antibiotic sparsomycin. These effects were not observed with TnaC(W12R)-tRNA(Pro) mutant complexes. These findings establish that Trp-12 of TnaC-tRNA(Pro) is required for introducing specific changes in the peptidyl transferase center of the ribosome that activate free tryptophan binding, resulting in peptidyl transferase inhibition. Free tryptophan appears to act at or near the binding sites of several antibiotics in the peptidyl transferase center. PMID:16505360

  1. Core Research Center

    USGS Publications Warehouse

    Hicks, Joshua; Adrian, Betty

    2009-01-01

    The Core Research Center (CRC) of the U.S. Geological Survey (USGS), located at the Denver Federal Center in Lakewood, Colo., currently houses rock core from more than 8,500 boreholes representing about 1.7 million feet of rock core from 35 States and cuttings from 54,000 boreholes representing 238 million feet of drilling in 28 States. Although most of the boreholes are located in the Rocky Mountain region, the geologic and geographic diversity of samples have helped the CRC become one of the largest and most heavily used public core repositories in the United States. Many of the boreholes represented in the collection were drilled for energy and mineral exploration, and many of the cores and cuttings were donated to the CRC by private companies in these industries. Some cores and cuttings were collected by the USGS along with other government agencies. Approximately one-half of the cores are slabbed and photographed. More than 18,000 thin sections and a large volume of analytical data from the cores and cuttings are also accessible. A growing collection of digital images of the cores are also becoming available on the CRC Web site Internet http://geology.cr.usgs.gov/crc/.

  2. 88 hours: The U.S. Geological Survey National Earthquake Information Center response to the 11 March 2011 Mw 9.0 Tohoku earthquake

    USGS Publications Warehouse

    Hayes, G.P.; Earle, P.S.; Benz, H.M.; Wald, D.J.; Briggs, R.W.

    2011-01-01

    This article presents a timeline of NEIC response to a major global earthquake for the first time in a formal journal publication. We outline the key observations of the earthquake made by the NEIC and its partner agencies, discuss how these analyses evolved, and outline when and how this information was released to the public and to other internal and external parties. Our goal in the presentation of this material is to provide a detailed explanation of the issues faced in the response to a rare, giant earthquake. We envisage that the timeline format of this presentation can highlight technical and procedural successes and shortcomings, which may in turn help prompt research by our academic partners and further improvements to our future response efforts. We have shown how NEIC response efforts have significantly improved over the past six years since the great 2004 Sumatra-Andaman earthquake. We are optimistic that the research spawned from this disaster, and the unparalleled dense and diverse data sets that have been recorded, can lead to similar-and necessary-improvements in the future.

  3. Lathosterol to cholesterol ratio in serum predicts cholesterol lowering response to plant sterol consumption in a dual center, randomized, single-blind placebo controlled trial

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Benefits of plant sterols (PS) for cholesterol lowering are compromised by large variability in efficacy across individuals. High fractional cholesterol synthesis measured by deuterium incorporation has been associated with non-response to PS consumption; however, prospective studies showing this as...

  4. When They Call, Will They Come? A Contextually Responsive Approach for Engaging Multistressed Families in an Urban Child Mental Health Center: A Randomized Clinical Trial

    ERIC Educational Resources Information Center

    Stern, Susan B.; Walsh, Margaret; Mercado, Micaela; Levene, Kathryn; Pepler, Debra J.; Carr, Ashley; Heppell, Allison; Lowe, Erin

    2015-01-01

    Objective: This study examines the effect of an ecological and contextually responsive approach, during initial intake call, on engagement for multistressed families seeking child mental health services in an urban setting. Methods: Using a randomized design, parents were allocated to phone Intake As Usual (IAU) or Enhanced Engagement Phone Intake…

  5. Increasing the Writing Performance of Urban Seniors Placed At-Risk through Goal-Setting in a Culturally Responsive and Creativity-Centered Classroom

    ERIC Educational Resources Information Center

    Estrada, Brittany; Warren, Susan

    2014-01-01

    Efforts to support marginalized students require not only identifying systemic inequities, but providing a classroom infrastructure that supports the academic achievement of all students. This action research study examined the effects of implementing goal-setting strategies and emphasizing creativity in a culturally responsive classroom (CRC) on…

  6. One Mission-Centered, Market-Smart Globalization Response: A Case Study of the Georgia Tech-Emory University Biomedical Engineering Curricular Joint Venture

    ERIC Educational Resources Information Center

    Burriss, Annie Hunt

    2010-01-01

    One innovative, higher-education response to globalization and changing fiscal realities is the curricular joint venture (CJV), a formal collaboration between academic institutions that leverages missions through new joint degrees and research not previously offered by collaborating institutions (Eckel, 2003). In 1997, a pioneering biomedical…

  7. Classroom Writing Tasks and Students' Analytic Text-Based Writing

    ERIC Educational Resources Information Center

    Matsumura, Lindsay Clare; Correnti, Richard; Wang, Elaine

    2015-01-01

    The Common Core State Standards emphasize students writing analytically in response to texts. Questions remain about the nature of instruction that develops students' text-based writing skills. In the present study, we examined the role that writing task quality plays in students' mastery of analytic text-based writing. Text-based writing tasks…

  8. Sol-Gel Matrices For Direct Colorimetric Detection Of Analytes

    DOEpatents

    Charych, Deborah H.; Sasaki, Darryl; Yamanaka, Stacey

    2002-11-26

    The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.

  9. Sol-gel matrices for direct colorimetric detection of analytes

    DOEpatents

    Charych, Deborah H.; Sasaki, Darryl; Yamanaka, Stacey

    2000-01-01

    The present invention relates to methods and compositions for the direct detection of analytes using color changes that occur in immobilized biopolymeric material in response to selective binding of analytes to their surface. In particular, the present invention provides methods and compositions related to the encapsulation of biopolymeric material into metal oxide glass using the sol-gel method.

  10. Approval of the Lemoore Center of the West Hills Community College District. A Report to the Governor and Legislature in Response to a Request from the Board of Governors to Recognize the Center as the Official Community College Center for the Lemoore/Hanford Area of Kings County.

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    The Lemoore Center of the West Hills Community College District serves the Lemoore/Hanford area of Kings and Fresno Counties--an area lying within both the West Hills and the College of the Sequoias Community College Districts. Jurisdictional problems between the districts prompted the Board of Governors of the California Community Colleges to…

  11. Automation of analytical isotachophoresis

    NASA Technical Reports Server (NTRS)

    Thormann, Wolfgang

    1985-01-01

    The basic features of automation of analytical isotachophoresis (ITP) are reviewed. Experimental setups consisting of narrow bore tubes which are self-stabilized against thermal convection are considered. Sample detection in free solution is discussed, listing the detector systems presently used or expected to be of potential use in the near future. The combination of a universal detector measuring the evolution of ITP zone structures with detector systems specific to desired components is proposed as a concept of an automated chemical analyzer based on ITP. Possible miniaturization of such an instrument by means of microlithographic techniques is discussed.

  12. Dual analyte detection using tandem flash luminescence.

    PubMed

    Adamczyk, Maciej; Moore, Jeffrey A; Shreder, Kevin

    2002-02-11

    A heterogeneous, dual analyte-binding assay which makes use of the flash luminescence from both aequorin and an acridinium-9-carboxamide label is presented. The signal generating species were triggered both differentially and sequentially using Ca(2+) followed by basic peroxide. Both signals were resolved readily using a single photomultiplier tube without the need for multiwavelength detection. To demonstrate the tandem luminescence concept in a model assay system, dose-response curves for two analytes, biotinylated BSA and myoglobin, were generated using a competitive binding format. Because of the relatively short assay time and the well-resolved signals, this format will be useful in the development of dual analyte high-throughput assays. PMID:11814805

  13. Analytical Chemistry Laboratory progress report for FY 1985

    SciTech Connect

    Green, D.W.; Heinrich, R.R.; Jensen, K.J.

    1985-12-01

    The Analytical Chemistry Laboratory is a full-cost-recovery service center, with the primary mission of providing a broad range of technical support services to the scientific and engineering programs at ANL. In addition, ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems, from routine standard analyses to unique problems that require significant development of methods and techniques. The purpose of this report is to summarize the technical and administrative activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year 1985 (October 1984 through September 1985). This is the second annual report for the ACL. 4 figs., 1 tab.

  14. Student-Centered Learning in Higher Education

    ERIC Educational Resources Information Center

    Wright, Gloria Brown

    2011-01-01

    In her book, "Learner-Centered Teaching", Maryellen Weimer contrasts the practices of teacher-centered college teaching and student-centered college teaching in terms of (1) the balance of power in the classroom, (2) the function of the course content, (3) the role of the teacher versus the role of the student, (4) the responsibility of learning,…

  15. Quality Indicators for Learning Analytics

    ERIC Educational Resources Information Center

    Scheffel, Maren; Drachsler, Hendrik; Stoyanov, Slavi; Specht, Marcus

    2014-01-01

    This article proposes a framework of quality indicators for learning analytics that aims to standardise the evaluation of learning analytics tools and to provide a mean to capture evidence for the impact of learning analytics on educational practices in a standardised manner. The criteria of the framework and its quality indicators are based on…

  16. Learning Analytics: Readiness and Rewards

    ERIC Educational Resources Information Center

    Friesen, Norm

    2013-01-01

    This position paper introduces the relatively new field of learning analytics, first by considering the relevant meanings of both "learning" and "analytics," and then by looking at two main levels at which learning analytics can be or has been implemented in educational organizations. Although integrated turnkey systems or…

  17. The analytic renormalization group

    NASA Astrophysics Data System (ADS)

    Ferrari, Frank

    2016-08-01

    Finite temperature Euclidean two-point functions in quantum mechanics or quantum field theory are characterized by a discrete set of Fourier coefficients Gk, k ∈ Z, associated with the Matsubara frequencies νk = 2 πk / β. We show that analyticity implies that the coefficients Gk must satisfy an infinite number of model-independent linear equations that we write down explicitly. In particular, we construct "Analytic Renormalization Group" linear maps Aμ which, for any choice of cut-off μ, allow to express the low energy Fourier coefficients for |νk | < μ (with the possible exception of the zero mode G0), together with the real-time correlators and spectral functions, in terms of the high energy Fourier coefficients for |νk | ≥ μ. Operating a simple numerical algorithm, we show that the exact universal linear constraints on Gk can be used to systematically improve any random approximate data set obtained, for example, from Monte-Carlo simulations. Our results are illustrated on several explicit examples.

  18. Applications of Business Analytics in Healthcare

    PubMed Central

    Ward, Michael J.; Marsolo, Keith A.

    2014-01-01

    The American healthcare system is at a crossroads, and analytics, as an organizational skill, figures to play a pivotal role in its future. As more healthcare systems capture information electronically and as they begin to collect more novel forms of data, such as human DNA, how will we leverage these resources and use them to improve human health at a manageable cost? In this article, we argue that analytics will play a fundamental role in the transformation of the American healthcare system. However, there are numerous challenges to the application and use of analytics, namely the lack of data standards, barriers to the collection of high-quality data, and a shortage of qualified personnel to conduct such analyses. There are also multiple managerial issues, such as how to get end users of electronic data to employ it consistently for improving healthcare delivery, and how to manage the public reporting and sharing of data. In this article, we explore applications of analytics in healthcare, barriers and facilitators to its widespread adoption, and how analytics can help us achieve the goals of the modern healthcare system: high-quality, responsive, affordable, and efficient care. PMID:25429161

  19. Commission Review of a Proposal by the State Center Community College District to Establish the Willow-International Community College Center: A Report to the Governor and Legislature in Response to a Request from the Board of Governors of the California Community Colleges. Commission Report 03-05

    ERIC Educational Resources Information Center

    California Postsecondary Education Commission, 2003

    2003-01-01

    This report reviews a proposal by the State Center Community College District to establish a State-approved education center in the city of Fresno. The center would be named the Willow-International Community College Center, and it would replace an existing Clovis operational outreach center that is considered by the district to be insufficient…

  20. Trace Analytical Techniques for Nuclear Forensics

    SciTech Connect

    Halverson, J.E.

    1999-04-28

    Over the history of the Savannah River Site, the Savannah River Technology Center (SRTC) has developed high sensitivity analytical capabilities in support of the Site's Environmental Monitoring Program and nuclear material protection process. Many of these techniques are applicable to the developing need for nuclear forensic analysis capabilities. Radiological and critically control procedures are in place at the SRTC, as well as clean room practices, to minimize the potential for a radiological evidentiary sample to contaminate personnel and the facility, as well as to minimize contaminating the sample thus rendering it useless by law enforcement agencies. Some of the trace analytical techniques available at the SRTC include ultra-low-level gamma and alpha spectrometry, high-sensitivity thermal ionization mass spectrometry, time-of-flight secondary ion mass spectrometry and trace organic analyses. These techniques have been tested during a planned domestic smuggling exercise and in the analysis of an unknown sample.In the event of an interdiction involving the illegal use or movement of radioactive material by U.S. law enforcement agencies (local, state or federal) forensic analyses will be used in developing and building a legal case against the perpetrators. The Savannah River Technology Center (SRTC) at the U.S. Department of Energy's Savannah River Site, a former nuclear production site currently conducting nuclear material stabilization missions, located in Aiken South Carolina, has a long history of performing trace analytical analyses for environmental monitoring. Many of these techniques are also applicable to nuclear forensic analyses. A summary of the trace analytical techniques used at the SRTC, which are applicable to Nuclear Forensics, is presented in this paper.Contamination control, of facilities and personnel involved in the analytical analyses, as well as preventing contamination of the sample, is a unique challenge for nuclear forensic analyses

  1. The Implementation and Evaluation of the Emergency Response Dose Assessment System (ERDAS) at Cape Canaveral Air Station/Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    Evans, Randolph J.; Tremback, Craig J.; Lyons, Walter A.

    1996-01-01

    The Emergency Response Dose Assessment System (ERDAS) is a system which combines the mesoscale meteorological prediction model RAMS with the diffusion models REEDM and HYPACT. Operators use a graphical user interface to run the models for emergency response and toxic hazard planning at CCAS/KCS. The Applied Meteorology Unit has been evaluating the ERDAS meteorological and diffusion models and obtained the following results: (1) RAMS adequately predicts the occurrence of the daily sea breeze during non-cloudy conditions for several cases. (2) RAMS shows a tendency to predict the sea breeze to occur slightly earlier and to move it further inland than observed. The sea breeze predictions could most likely be improved by better parameterizing the soil moisture and/or sea surface temperatures. (3) The HYPACT/REEDM/RAMS models accurately predict launch plume locations when RAMS winds are accurate and when the correct plume layer is modeled. (4) HYPACT does not adequately handle plume buoyancy for heated plumes since all plumes are presently treated as passive tracers. Enhancements should be incorporated into the ERDAS as it moves toward being a fully operational system and as computer workstations continue to increase in power and decrease in cost. These enhancements include the following: activate RAMS moisture physics; use finer RAMS grid resolution; add RAMS input parameters (e.g. soil moisture, radar, and/or satellite data); automate data quality control; implement four-dimensional data assimilation; modify HYPACT plume rise and deposition physics; and add cumulative dosage calculations in HYPACT.

  2. The Duration of an Exposure Response Gradient between Incident Obstructive Airways Disease and Work at the World Trade Center Site: 2001-2011

    PubMed Central

    Hall, Charles B.; Liu, Xiaoxue; Zeig-Owens, Rachel; Webber, Mayris P.; Aldrich, Thomas K.; Weakley, Jessica; Schwartz, Theresa; Cohen, Hillel W.; Glaser, Michelle S.; Olivieri, Brianne L.; Weiden, Michael D.; Nolan, Anna; Kelly, Kerry J.; Prezant, David J.

    2015-01-01

    Background: Adverse respiratory effects of World Trade Center (WTC) exposure have been widely documented, but the length of time that exposure remains associated with disease is uncertain. We estimate the incidence of new cases of physician-diagnosed obstructive airway disease (OAD) as a function of time since 9/11/2001 in WTC-exposed firefighters. Methods: Exposure was categorized by first WTC arrival time: high (9/11/2001 AM); moderate (9/11/2001 PM or 9/12/2001); or low (9/13-24/2001). We modeled relative rates (RR) and 95% confidence intervals (CI) of OAD incidence by exposure over the first 10 years post-9/11/2001, estimating the time(s) of change in the RR with change point models. We further examined the relationship between self-reported lower respiratory symptoms and physician diagnoses. Results: Change points were observed at 15 and 84 months post-9/11/2001, with relative incidence rates for the high versus low exposure group of 4.02 (95% CI 2.62-6.16) prior to 15 months, 1.90 (95% CI 1.49-2.44) from months 16 to 84, and 1.20 (95% CI 0.92-1.56) thereafter. Incidence in all exposure groups increased after the WTC health program began to offer free coverage of OAD medications in month 63. Self-reported lower respiratory symptoms in the first 15 months had 80.6% sensitivity, but only 35.9% specificity, for eventual OAD diagnoses. Conclusions: New OAD diagnoses are associated with WTC exposure for at least seven years. Some portion of the extended duration of that association may be due to delayed diagnoses. Nevertheless, our results support recognizing OAD among rescue workers as WTC-related even when diagnosed years after exposure. PMID:26064784

  3. Response to the great East Japan earthquake of 2011 and the Fukushima nuclear crisis: the case of the Laboratory Animal Research Center at Fukushima Medical University.

    PubMed

    Katahira, Kiyoaki; Sekiguchi, Miho

    2013-01-01

    A magnitude 9.0 great earthquake, the 2011 off the Pacific coast of Tohoku Earthquake, occurred on March 11, 2011, and subsequent Fukushima Daiichi Nuclear Power Station (Fukushima NPS) accidents stirred up natural radiation around the campus of Fukushima Medical University (FMU). FMU is located in Fukushima City, and is 57 km to the northwest of Fukushima NPS. Due to temporary failure of the steam boilers, the air conditioning system for the animal rooms, all autoclaves, and a cage washer could not be used at the Laboratory Animal Research Center (LARC) of FMU. The outside air temperature dropped to zero overnight, and the temperature inside the animal rooms fell to 10°C for several hours. We placed sterilized nesting materials inside all cages to encourage rodents to create nests. The main water supply was cut off for 8 days in all, while supply of steam and hot water remained unavailable for 12 days. It took 20 days to restore the air conditioning system to normal operation at the facility. We measured radiation levels in the animal rooms to confirm the safety of care staff and researchers. On April 21, May 9, and June 17, the average radiation levels at a central work table in the animal rooms with HEPA filters were 46.5, 44.4, and 43.4 cpm, respectively, which is equal to the background level of the equipment. We sincerely hope our experiences will be a useful reference regarding crisis management for many institutes having laboratory animals. PMID:23615301

  4. VERDE Analytic Modules

    Energy Science and Technology Software Center (ESTSC)

    2008-01-15

    The Verde Analytic Modules permit the user to ingest openly available data feeds about phenomenology (storm tracks, wind, precipitation, earthquake, wildfires, and similar natural and manmade power grid disruptions and forecast power outages, restoration times, customers outaged, and key facilities that will lose power. Damage areas are predicted using historic damage criteria of the affected area. The modules use a cellular automata approach to estimating the distribution circuits assigned to geo-located substations. Population estimates servedmore » within the service areas are located within 1 km grid cells and converted to customer counts by conversion through demographic estimation of households and commercial firms within the population cells. Restoration times are estimated by agent-based simulation of restoration crews working according to utility published prioritization calibrated by historic performance.« less

  5. VERDE Analytic Modules

    SciTech Connect

    2008-01-15

    The Verde Analytic Modules permit the user to ingest openly available data feeds about phenomenology (storm tracks, wind, precipitation, earthquake, wildfires, and similar natural and manmade power grid disruptions and forecast power outages, restoration times, customers outaged, and key facilities that will lose power. Damage areas are predicted using historic damage criteria of the affected area. The modules use a cellular automata approach to estimating the distribution circuits assigned to geo-located substations. Population estimates served within the service areas are located within 1 km grid cells and converted to customer counts by conversion through demographic estimation of households and commercial firms within the population cells. Restoration times are estimated by agent-based simulation of restoration crews working according to utility published prioritization calibrated by historic performance.

  6. Analytical sensor redundancy assessment

    NASA Technical Reports Server (NTRS)

    Mulcare, D. B.; Downing, L. E.; Smith, M. K.

    1988-01-01

    The rationale and mechanization of sensor fault tolerance based on analytical redundancy principles are described. The concept involves the substitution of software procedures, such as an observer algorithm, to supplant additional hardware components. The observer synthesizes values of sensor states in lieu of their direct measurement. Such information can then be used, for example, to determine which of two disagreeing sensors is more correct, thus enhancing sensor fault survivability. Here a stability augmentation system is used as an example application, with required modifications being made to a quadruplex digital flight control system. The impact on software structure and the resultant revalidation effort are illustrated as well. Also, the use of an observer algorithm for wind gust filtering of the angle-of-attack sensor signal is presented.

  7. Normality in Analytical Psychology

    PubMed Central

    Myers, Steve

    2013-01-01

    Although C.G. Jung’s interest in normality wavered throughout his career, it was one of the areas he identified in later life as worthy of further research. He began his career using a definition of normality which would have been the target of Foucault’s criticism, had Foucault chosen to review Jung’s work. However, Jung then evolved his thinking to a standpoint that was more aligned to Foucault’s own. Thereafter, the post Jungian concept of normality has remained relatively undeveloped by comparison with psychoanalysis and mainstream psychology. Jung’s disjecta membra on the subject suggest that, in contemporary analytical psychology, too much focus is placed on the process of individuation to the neglect of applications that consider collective processes. Also, there is potential for useful research and development into the nature of conflict between individuals and societies, and how normal people typically develop in relation to the spectrum between individuation and collectivity. PMID:25379262

  8. A Multi-Center Pilot Evaluation of the National Institutes of Health Chronic Graft-versus-Host Disease (cGVHD) Therapeutic Response Measures: Feasibility, Inter-rater Reliability, and Minimum Detectable Change

    PubMed Central

    Mitchell, Sandra A.; Jacobsohn, David; Thormann Powers, Kimberly E.; Carpenter, Paul A.; Flowers, Mary E.D.; Cowen, Edward W.; Schubert, Mark; Turner, Maria; Lee, Stephanie J.; Martin, Paul; Bishop, Michael R.; Baird, Kristin; Bolaños-Meade, Javier; Boyd, Kevin; Fall-Dickson, Jane M.; Gerber, Lynn H.; Guadagnini, Jean-Pierre; Imanguli, Matin; Krumlauf, Michael C.; Lawley, Leslie; Li, Li; Reeve, Bryce B.; Clayton, Janine Austin; Vogelsang, Georgia B.; Pavletic, Steven Z.

    2011-01-01

    the NIH response criteria are feasible for use, and these reliability estimates are encouraging, because they were observed following a single 2.5 hour training session given at multiple transplant centers, with no opportunity for iterative training and calibration. Research is needed to evaluate inter- and intra-rater reliability in larger samples, and to evaluate these response criteria as predictors of outcomes in clinical trials. PMID:21536143

  9. Cessation of tyrosine kinase inhibitors in patients with chronic-phase chronic myelogenous leukemia following durable complete molecular response: a single center facing the dilemma.

    PubMed

    Iliakis, Theodoros; Papadopoulou, Vasiliki; Diamantopoulos, Panagiotis T; Panayiotidis, Panayiotis; Zervakis, Konstantinos; Giannakopoulou, Nefeli; Tilimidos, Gerassimos; Angelopoulou, Maria; Siakantaris, Marina P; Pangalis, Gerassimos; Mantzourani, Marina; Variami, Eleni; Viniou, Nora Athina

    2013-08-01

    Tyrosine kinase inhibitors (TKIs), namely imatinib mesylate (IM) and recently approved second-generation TKIs dasatinib and nilotinib, are currently considered the treatment of choice for newly-diagnosed chronic phase chronic myelogenous leukemia (CP-CML). Although treatment with TKIs has not yet been proven curative, it certainly accomplishes a sustained control of the disease in the vast majority of patients. More than a decade after the successful launching of IM in first-line treatment of CP-CML and the subsequent introduction of second-generation TKIs in this setting, the question of the possibility of TKI cessation in a specific subset of patients has emerged. Side-effects of TKIs, along with some patients' wish to abandon the drugs and the rising financial burden upon healthcare systems, have led to the dilemma whether IM can be safely withdrawn after achieving deep molecular remissions and which patients are suitable for this discontinuation. We examined the data of our patients with CML in search of potential canditates for cessation of TKI therapy and identified their characteristics. We also performed a thorough review of the relevant literature. Eight out of fifty patients were discriminated on grounds of sustained complete molecular response (CMR) exceeding 12 months, most of them with a low or intermediate Sokal score at diagnosis. The median interval from IM initiation to CMR was almost 2 years and the median duration of detected CMR reached 6.5 years. Based on the promising results of prospective clinical trials reporting successful cessation of treatment with TKIs on selected subgroups of patients, we decided to proceed to interruption of therapy in the specific subset of our patients and closely monitor their response. PMID:23898127

  10. Better questions, better answers: reporting vs. analytics.

    PubMed

    Bhatia, Uhiren

    2015-07-01

    Tracking performance through reporting is a basic obligation for responsible lab management. But creative, visionary leadership requires that lab leaders ask better questions, reach better conclusions, and transform those conclusions into action to achieve better results. The clinical lab has always had the breadth of data to contribute to that process. With analytics, lab leaders now have the depth and control to effect positive change as well. PMID:26299148

  11. Visual analytics for power grid contingency analysis.

    PubMed

    Pak Chung Wong; Zhenyu Huang; Yousu Chen; Mackey, Patrick; Shuangshuang Jin

    2014-01-01

    Contingency analysis employs different measures to model scenarios, analyze them, and then derive the best response to any threats. A proposed visual-analytics pipeline for power grid management can transform approximately 100 million contingency scenarios to a manageable size and form. Grid operators can examine individual scenarios and devise preventive or mitigation strategies in a timely manner. Power grid engineers have applied the pipeline to a Western Electricity Coordinating Council power grid model. PMID:24808167

  12. Vibration Based Crack Detection in a Rotating Disk. Part 1; An Analytical Study

    NASA Technical Reports Server (NTRS)

    Gyekenyesi, Andrew L.; Sawicki, Jerzy T.; Baaklini, George Y.

    2003-01-01

    This paper describes the analytical results concerning the detection of a crack in a rotating disk. The concept of the approach is based on the fact that the development of a disk crack results in a distorted strain field within the component. As a result, a minute deformation in the disk's geometry as well as a change in the system s center of mass occurs. Finite element analyses were conducted concerning a notched disk in order to define the sensitivity of the method. The notch was used to simulate an actual crack and will be the method utilized for upcoming experiments. Various notch sizes were studied. The geometric deformations and shifts of center of mass were documented as a function of rotational speed. In addition, a rotordynamic analysis of a 2-bearing, disk and shaft system was conducted. The overall response of the system was required in order to design the experimental system for operation beyond the first critical. The results of the FE analyses of the disk indicated that the overall changes in the disk s geometry and center of mass were rather small. The difference between the maximum centrifugal radial displacements between the undamaged and damaged disks at 8000 RPM was 0.00014 in. for a 0.963 in. notch length. The shift in center of mass was also of this magnitude. The next step involves running experiments to verify the analysis.

  13. Analytic integrable systems: Analytic normalization and embedding flows

    NASA Astrophysics Data System (ADS)

    Zhang, Xiang

    In this paper we mainly study the existence of analytic normalization and the normal form of finite dimensional complete analytic integrable dynamical systems. More details, we will prove that any complete analytic integrable diffeomorphism F(x)=Bx+f(x) in (Cn,0) with B having eigenvalues not modulus 1 and f(x)=O(|) is locally analytically conjugate to its normal form. Meanwhile, we also prove that any complete analytic integrable differential system x˙=Ax+f(x) in (Cn,0) with A having nonzero eigenvalues and f(x)=O(|) is locally analytically conjugate to its normal form. Furthermore we will prove that any complete analytic integrable diffeomorphism defined on an analytic manifold can be embedded in a complete analytic integrable flow. We note that parts of our results are the improvement of Moser's one in J. Moser, The analytic invariants of an area-preserving mapping near a hyperbolic fixed point, Comm. Pure Appl. Math. 9 (1956) 673-692 and of Poincaré's one in H. Poincaré, Sur l'intégration des équations différentielles du premier order et du premier degré, II, Rend. Circ. Mat. Palermo 11 (1897) 193-239. These results also improve the ones in Xiang Zhang, Analytic normalization of analytic integrable systems and the embedding flows, J. Differential Equations 244 (2008) 1080-1092 in the sense that the linear part of the systems can be nonhyperbolic, and the one in N.T. Zung, Convergence versus integrability in Poincaré-Dulac normal form, Math. Res. Lett. 9 (2002) 217-228 in the way that our paper presents the concrete expression of the normal form in a restricted case.

  14. Three Methods of Finding Center of Mass.

    ERIC Educational Resources Information Center

    Reidl, Charles J., Jr.

    1995-01-01

    Presents a procedure that students can use to determine the center of mass of a thin (two-dimensional), homogenous object experimentally, analytically, and numerically. Requires students to use three distinctly different approaches to a single problem and necessitates a combination of laboratory skills, a knowledge of fundamental calculus, and…

  15. The Centers of Similarity of Two Non-Congruent Squares

    ERIC Educational Resources Information Center

    Ayoub, Ayoub B.

    2004-01-01

    The topic of centers of similarity can be treated synthetically or analytically. While the synthetic method is more practiced, the analytic approach is more appropriate when the problem is given in an analytic geometry setting. In this article, two non-congruent squares ABCD and A'B'C'D' are given, where A(0,0), B(3,0), C(3,3), D(0,3) and A'(5,4),…

  16. Hanford transuranic analytical capability

    SciTech Connect

    McVey, C.B.

    1995-02-24

    With the current DOE focus on ER/WM programs, an increase in the quantity of waste samples that requires detailed analysis is forecasted. One of the prime areas of growth is the demand for DOE environmental protocol analyses of TRU waste samples. Currently there is no laboratory capacity to support analysis of TRU waste samples in excess of 200 nCi/gm. This study recommends that an interim solution be undertaken to provide these services. By adding two glove boxes in room 11A of 222S the interim waste analytical needs can be met for a period of four to five years or until a front end facility is erected at or near the 222-S facility. The yearly average of samples is projected to be approximately 600 samples. The figure has changed significantly due to budget changes and has been downgraded from 10,000 samples to the 600 level. Until these budget and sample projection changes become firmer, a long term option is not recommended at this time. A revision to this document is recommended by March 1996 to review the long term option and sample projections.

  17. Analytics for Metabolic Engineering

    PubMed Central

    Petzold, Christopher J.; Chan, Leanne Jade G.; Nhan, Melissa; Adams, Paul D.

    2015-01-01

    Realizing the promise of metabolic engineering has been slowed by challenges related to moving beyond proof-of-concept examples to robust and economically viable systems. Key to advancing metabolic engineering beyond trial-and-error research is access to parts with well-defined performance metrics that can be readily applied in vastly different contexts with predictable effects. As the field now stands, research depends greatly on analytical tools that assay target molecules, transcripts, proteins, and metabolites across different hosts and pathways. Screening technologies yield specific information for many thousands of strain variants, while deep omics analysis provides a systems-level view of the cell factory. Efforts focused on a combination of these analyses yield quantitative information of dynamic processes between parts and the host chassis that drive the next engineering steps. Overall, the data generated from these types of assays aid better decision-making at the design and strain construction stages to speed progress in metabolic engineering research. PMID:26442249

  18. Use of positron emission tomography scan response to guide treatment change for locally advanced gastric cancer: the Memorial Sloan Kettering Cancer Center experience

    PubMed Central

    Won, Elizabeth; Shah, Manish A.; Schöder, Heiko; Strong, Vivian E.; Coit, Daniel G.; Brennan, Murray F.; Kelsen, David P.; Janjigian, Yelena Y.; Tang, Laura H.; Capanu, Marinela; Rizk, Nabil P.; Allen, Peter J.; Bains, Manjit S.

    2016-01-01

    Background Early metabolic response on 18-fluorodeoxyglucose-positron emission tomography (FDG-PET) during neoadjuvant chemotherapy is PET non-responders have poor outcomes whether continuing chemotherapy or proceeding directly to surgery. Use of PET may identify early treatment failure, sparing patients from inactive therapy and allowing for crossover to alternative therapies. We examined the effectiveness of PET directed switching to salvage chemotherapy in the PET non-responders. Methods Patients with locally advanced resectable FDG-avid gastric or gastroesophageal junction (GEJ) adenocarcinoma received bevacizumab 15 mg/kg, epirubicin 50 mg/m2, cisplatin 60 mg/m2 day 1, and capecitabine 625 mg/m2 bid (ECX) every 21 days. PET scan was obtained at baseline and after cycle 1. PET responders, (i.e., ≥35% reduction in FDG uptake at the primary tumor) continued ECX + bev. Non-responders switched to docetaxel 30 mg/m2, irinotecan 50 mg/mg2 day 1 and 8 plus bevacizumab every 21 days for 2 cycles. Patients then underwent surgery. The primary objective was to improve the 2-year disease free survival (DFS) from 30% (historical control) to 53% in the non-responders. Results Twenty evaluable patients enrolled before the study closed for poor accrual. Eleven were PET responders and the 9 non-responders switched to the salvage regimen. With a median follow-up of 38.2 months, the 2-year DFS was 55% [95% confidence interval (CI), 30–85%] in responders compared with 56% in the non-responder group (95% CI, 20–80%, P=0.93). Conclusions The results suggest that changing chemotherapy regimens in PET non-responding patients may improve outcomes. Results from this pilot trial are hypothesis generating and suggest that PET directed neoadjuvant therapy merits evaluation in a larger trial. PMID:27563439

  19. Analytical control test plan and microbiological methods for the water recovery test

    NASA Technical Reports Server (NTRS)

    Traweek, M. S. (Editor); Tatara, J. D. (Editor)

    1994-01-01

    Qualitative and quantitative laboratory results are important to the decision-making process. In some cases, they may represent the only basis for deciding between two or more given options or processes. Therefore, it is essential that handling of laboratory samples and analytical operations employed are performed at a deliberate level of conscientious effort. Reporting erroneous results can lead to faulty interpretations and result in misinformed decisions. This document provides analytical control specifications which will govern future test procedures related to all Water Recovery Test (WRT) Phase 3 activities to be conducted at the National Aeronautics and Space Administration/Marshall Space Flight Center (NASA/MSFC). This document addresses the process which will be used to verify analytical data generated throughout the test period, and to identify responsibilities of key personnel and participating laboratories, the chains of communication to be followed, and ensure that approved methodology and procedures are used during WRT activities. This document does not outline specifics, but provides a minimum guideline by which sampling protocols, analysis methodologies, test site operations, and laboratory operations should be developed.

  20. Morphological and pathological response in primary systemic therapy of patients with breast cancer and the prediction of disease free survival: a single center observational study

    PubMed Central

    Szentmártoni, Gyöngyvér; Tőkés, Anna-Mária; Tőkés, Timea; Somlai, Krisztián; Szász, Attila Marcell; Torgyík, László; Kulka, Janina; Dank, Magdolna

    2016-01-01

    Aim To identify breast cancer subtypes likely to respond to primary systemic therapy (PST or neoadjuvant therapy) and to assess the accuracy of physical examination (PE) and breast ultrasonography (US) in evaluating and predicting residual size of breast carcinoma following PST. Methods 116 patients who received at least two cycles of PST between 1998 and 2009 were selected from a prospectively collected clinical database. Radiological assessment was done by mammography and US. Prior to PST, tumors were subclassified according to core biopsy (NCB) and/or fine-needle aspiration-based immunohistochemical profiles of NCB. Pathological response rates were assessed following the surgeries by using Chevallier classification. Tumor measurements by PE and US were obtained before and after PST. Different clinical measurements were compared with histological findings. Disease-free survival (DFS) was assessed. Results Pathological complete remission (pCR = Chevallier I/II) was observed in 25 patients (21.5%), 44% of whom had triple negative histology, 28% Her2 positive and 76% had high-grade tumor. Of 116 patients, 24 received taxane-based PST, 48 combined taxane + anthracycline treatment, 8 trastuzumab combinations, 21 anthracycline-based treatments, and 15 other treatments. In the taxane treated group, the pCR rate was 30%, in the taxane + anthracycline group 25%, in the anthracycline group 9.5%, and in trastuzumab group 37.5%. After PST, PE and US were both significantly associated with pathology (P < 0.001 and P = 0.004, respectively). Concerning OS, significant difference was observed between the Chevallier III and IV group (P = 0.031) in favor of Chevallier III group. In the pCR group, fewer events were observed during the follow-up period. Conclusions Our results show that even limited, routinely used immunohistochemical profiling of tumors can predict the likelihood of pCR to PST: patients with triple negative and Her2-positive cancers are more

  1. Analytical model of internally coupled ears.

    PubMed

    Vossen, Christine; Christensen-Dalsgaard, Jakob; van Hemmen, J Leo

    2010-08-01

    Lizards and many birds possess a specialized hearing mechanism: internally coupled ears where the tympanic membranes connect through a large mouth cavity so that the vibrations of the tympanic membranes influence each other. This coupling enhances the phase differences and creates amplitude differences in the tympanic membrane vibrations. Both cues show strong directionality. The work presented herein sets out the derivation of a three dimensional analytical model of internally coupled ears that allows for calculation of a complete vibration profile of the membranes. The analytical model additionally provides the opportunity to incorporate the effect of the asymmetrically attached columella, which leads to the activation of higher membrane vibration modes. Incorporating this effect, the analytical model can explain measurements taken from the tympanic membrane of a living lizard, for example, data demonstrating an asymmetrical spatial pattern of membrane vibration. As the analytical calculations show, the internally coupled ears increase the directional response, appearing in large directional internal amplitude differences (iAD) and in large internal time differences (iTD). Numerical simulations of the eigenfunctions in an exemplary, realistically reconstructed mouth cavity further estimate the effects of its complex geometry. PMID:20707461

  2. ICOS Atmospheric Thematic Center

    NASA Astrophysics Data System (ADS)

    Rivier, Leonard; Hazan, Lynn; Tarniewicz, Jerome; Laurent, Olivier; Yver, Camille; Laurila, Tuomas; Paris, Jean-Daniel; Ramonet, Michel; Ciais, Philippe

    2014-05-01

    ICOS is a recently-launched, world-class research infrastructure dedicated to the monitoring and improved understanding of carbon sources and sinks. It consists of complementary, harmonized networks of long-term ecosystem monitoring stations focusing on Europe and adjacent regions. The ICOS networks will comprise about 40 operational atmospheric stations (measuring atmospheric composition in greenhouse gases and other core parameters), 30 ecosystem stations (measuring fluxes from ecosystems) and about 10 oceanic measurement platforms. The networks will be coordinated through a set of central facilities: three Thematic centres respectively for atmospheric, ecosystem and ocean data, and a Central analytical lab. The mission of the thematic centres are to process, validate and distribute data to end-users. ICOS will also set up a Carbon portal dedicated to easy discovery of and access to data and elaborated products such as flux maps by end users.The Atmospheric Thematic Center (ATC) has three main functions: Operate the atmospheric data processing chains, going from data transmission from stations to the routine delivery of quality checked data-stream Carry out regular measurement technology survey, analysis and enable development of new sensors and their testing Monitor the network and propose spare instruments, training, and technical assistance.

  3. Detecting themes of public concern: a text mining analysis of the Centers for Disease Control and Prevention's Ebola live Twitter chat.

    PubMed

    Lazard, Allison J; Scheinfeld, Emily; Bernhardt, Jay M; Wilcox, Gary B; Suran, Melissa

    2015-10-01

    A diagnosis of Ebola on US soil triggered widespread panic. In response, the Centers for Disease Control and Prevention held a live Twitter chat to address public concerns. This study applied a textual analytics method to reveal insights from these tweets that can inform communication strategies. User-generated tweets were collected, sorted, and analyzed to reveal major themes. The public was concerned with symptoms and lifespan of the virus, disease transfer and contraction, safe travel, and protection of one's body. PMID:26138998

  4. Analytical laboratory quality audits

    SciTech Connect

    Kelley, William D.

    2001-06-11

    Analytical Laboratory Quality Audits are designed to improve laboratory performance. The success of the audit, as for many activities, is based on adequate preparation, precise performance, well documented and insightful reporting, and productive follow-up. Adequate preparation starts with definition of the purpose, scope, and authority for the audit and the primary standards against which the laboratory quality program will be tested. The scope and technical processes involved lead to determining the needed audit team resources. Contact is made with the auditee and a formal audit plan is developed, approved and sent to the auditee laboratory management. Review of the auditee's quality manual, key procedures and historical information during preparation leads to better checklist development and more efficient and effective use of the limited time for data gathering during the audit itself. The audit begins with the opening meeting that sets the stage for the interactions between the audit team and the laboratory staff. Arrangements are worked out for the necessary interviews and examination of processes and records. The information developed during the audit is recorded on the checklists. Laboratory management is kept informed of issues during the audit so there are no surprises at the closing meeting. The audit report documents whether the management control systems are effective. In addition to findings of nonconformance, positive reinforcement of exemplary practices provides balance and fairness. Audit closure begins with receipt and evaluation of proposed corrective actions from the nonconformances identified in the audit report. After corrective actions are accepted, their implementation is verified. Upon closure of the corrective actions, the audit is officially closed.

  5. A special issue on the patient-centered medical home.

    PubMed

    Blount, Alexander

    2010-12-01

    This special issue on the Patient-Centered Medical Home (PCMH) reflects its times. At the present time, the PCMH is an aspirational model with a few pilots functioning well around the country. How long the current period of idealism, fueled by the energy of early adopters, the consensus of diverse stakeholders, and the dollars of the Affordable Care Act will continue is anybody's guess. Representing the thinking of some of the best minds in the field, the articles in this issue have an aspirational and idealistic tone as much as a descriptive and analytic one. A year ago the balance would have been tipped more toward idealism and model building and a year from now it would, in all likelihood, tip more toward model description and analysis. The authors in this volume have been personally responsible for helping to move behavioral health to a more central position in the PCMH model. PMID:21299276

  6. Analytic solutions of an unclassified artifact /

    SciTech Connect

    Trent, Bruce C.

    2012-03-01

    This report provides the technical detail for analytic solutions for the inner and outer profiles of the unclassified CMM Test Artifact (LANL Part Number 157Y-700373, 5/03/2001) in terms of radius and polar angle. Furthermore, analytic solutions are derived for the legacy Sheffield measurement hardware, also in terms of radius and polar angle, using part coordinates, i.e., relative to the analytic profile solutions obtained. The purpose of this work is to determine the exact solution for the “cosine correction” term inherent to measurement with the Sheffield hardware. The cosine correction is required in order to interpret the actual measurements taken by the hardware in terms of an actual part definition, or “knot-point spline definition,” that typically accompanies a component drawing. Specifically, there are two portions of the problem: first an analytic solution must be obtained for any point on the part, e.g., given the radii and the straight lines that define the part, it is required to find an exact solution for the inner and outer profile for any arbitrary polar angle. Next, the problem of the inspection of this part must be solved, i.e., given an arbitrary sphere (representing the inspection hardware) that comes in contact with the part (inner and outer profiles) at any arbitrary polar angle, it is required to determine the exact location of that intersection. This is trivial for the case of concentric circles. In the present case, however, the spherical portion of the profiles is offset from the defined center of the part, making the analysis nontrivial. Here, a simultaneous solution of the part profiles and the sphere was obtained.

  7. SPECIAL LIBRARIES AND INFORMATION CENTERS.

    ERIC Educational Resources Information Center

    KRUZAS, ANTHONY T.

    DATA PRESENTED IN THIS REPORT WERE BASED PRIMARILY ON QUESTIONNAIRE RESPONSES OBTAINED THROUGH A NATIONAL CENSUS OF SPECIAL LIBRARIES AND INFORMATION CENTERS. THE SURVEY WAS MADE DURING THE PERIOD FROM AUGUST 1961 TO FEBRUARY 1963. ALTHOUGH THERE WERE MORE THAN 10,000 ENTRIES IN THE PUBLISHED DIRECTORY, EXCLUSION OF CANADIAN LIBRARIES AND DELETION…

  8. Insights from advanced analytics at the Veterans Health Administration.

    PubMed

    Fihn, Stephan D; Francis, Joseph; Clancy, Carolyn; Nielson, Christopher; Nelson, Karin; Rumsfeld, John; Cullen, Theresa; Bates, Jack; Graham, Gail L

    2014-07-01

    Health care has lagged behind other industries in its use of advanced analytics. The Veterans Health Administration (VHA) has three decades of experience collecting data about the veterans it serves nationwide through locally developed information systems that use a common electronic health record. In 2006 the VHA began to build its Corporate Data Warehouse, a repository for patient-level data aggregated from across the VHA's national health system. This article provides a high-level overview of the VHA's evolution toward "big data," defined as the rapid evolution of applying advanced tools and approaches to large, complex, and rapidly changing data sets. It illustrates how advanced analysis is already supporting the VHA's activities, which range from routine clinical care of individual patients--for example, monitoring medication administration and predicting risk of adverse outcomes--to evaluating a systemwide initiative to bring the principles of the patient-centered medical home to all veterans. The article also shares some of the challenges, concerns, insights, and responses that have emerged along the way, such as the need to smoothly integrate new functions into clinical workflow. While the VHA is unique in many ways, its experience may offer important insights for other health care systems nationwide as they venture into the realm of big data. PMID:25006147

  9. Children's cancer centers

    MedlinePlus

    Pediatric cancer center; Pediatric oncology center; Comprehensive cancer center ... Treating childhood cancer is not the same as treating adult cancer. The cancers are different. So are the treatments and the ...

  10. The Watergate Learning Center

    ERIC Educational Resources Information Center

    Training in Business and Industry, 1971

    1971-01-01

    The Watergate Learning Center, recently opened by Sterling Learning Center in Washington, D. C., blueprints the plan established by Sterling and Marriott Hotels for a national chain of learning centers with much the same facilities. (EB)

  11. Fireworks Information Center

    MedlinePlus

    ... Home / Safety Education / Safety Education Centers En Español Fireworks Information Center This is an information center on ... Video Put Safety First This Fourth of July Fireworks Information What are consumer fireworks and where are ...

  12. The Case for Assessment Analytics

    ERIC Educational Resources Information Center

    Ellis, Cath

    2013-01-01

    Learning analytics is a relatively new field of inquiry and its precise meaning is both contested and fluid (Johnson, Smith, Willis, Levine & Haywood, 2011; LAK, n.d.). Ferguson (2012) suggests that the best working definition is that offered by the first Learning Analytics and Knowledge (LAK) conference: "the measurement, collection,…

  13. Understanding Education Involving Geovisual Analytics

    ERIC Educational Resources Information Center

    Stenliden, Linnea

    2013-01-01

    Handling the vast amounts of data and information available in contemporary society is a challenge. Geovisual Analytics provides technology designed to increase the effectiveness of information interpretation and analytical task solving. To date, little attention has been paid to the role such tools can play in education and to the extent to which…

  14. Analytical Chemistry Laboratory, progress report for FY 1993

    SciTech Connect

    Not Available

    1993-12-01

    The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1993 (October 1992 through September 1993). This annual report is the tenth for the ACL and describes continuing effort on projects, work on new projects, and contributions of the ACL staff to various programs at ANL. The Analytical Chemistry Laboratory is a full-cost-recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. The ACL also has research programs in analytical chemistry, conducts instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems. Some routine or standard analyses are done, but it is common for the Argonne programs to generate unique problems that require development or modification of methods and adaption of techniques to obtain useful analytical data. The ACL is administratively within the Chemical Technology Division (CMT), its principal ANL client, but provides technical support for many of the technical divisions and programs at ANL. The ACL has four technical groups--Chemical Analysis, Instrumental Analysis, Organic Analysis, and Environmental Analysis--which together include about 45 technical staff members. Talents and interests of staff members cross the group lines, as do many projects within the ACL.

  15. Characterization of Analytical Reference Glass-1 (ARG-1)

    SciTech Connect

    Smith, G.L.

    1993-12-01

    High-level radioactive waste may be immobilized in borosilicate glass at the West Valley Demonstration Project, West Valley, New York, the Defense Waste Processing Facility (DWPF), Aiken, South Carolina, and the Hanford Waste Vitrification Project (HWVP), Richland, Washington. The vitrified waste form will be stored in stainless steel canisters before its eventual transfer to a geologic repository for long-term disposal. Waste Acceptance Product Specifications (WAPS) (DOE 1993), Section 1.1.2 requires that the waste form producers must report the measured chemical composition of the vitrified waste in their production records before disposal. Chemical analysis of glass waste forms is receiving increased attention due to qualification requirements of vitrified waste forms. The Pacific Northwest Laboratory (PNL) has been supporting the glass producers` analytical laboratories by a continuing program of multilaboratory analytical testing using interlaboratory ``round robin`` methods. At the PNL Materials Characterization Center Analytical Round Robin 4 workshop ``Analysis of Nuclear Waste Glass and Related Materials,`` January 16--17, 1990, Pleasanton, California, the meeting attendees decided that simulated nuclear waste analytical reference glasses were needed for use as analytical standards. Use of common standard analytical reference materials would allow the glass producers` analytical laboratories to calibrate procedures and instrumentation, to control laboratory performance and conduct self-appraisals, and to help qualify their various waste forms.

  16. National Wind Tecnology Center Provides Dual Axis Resonant Blade Testing

    ScienceCinema

    Felker, Fort

    2014-06-10

    NREL's Structural Testing Laboratory at the National Wind Technology Center (NWTC) provides experimental laboratories, computer facilities for analytical work, space for assembling components and turbines for atmospheric testing as well as office space for industry researchers. Fort Felker, center director at the NWTC, discusses NREL's state-of-the-art structural testing capabilities and shows a flapwise and edgewise blade test in progress.

  17. National Wind Tecnology Center Provides Dual Axis Resonant Blade Testing

    SciTech Connect

    Felker, Fort

    2013-11-13

    NREL's Structural Testing Laboratory at the National Wind Technology Center (NWTC) provides experimental laboratories, computer facilities for analytical work, space for assembling components and turbines for atmospheric testing as well as office space for industry researchers. Fort Felker, center director at the NWTC, discusses NREL's state-of-the-art structural testing capabilities and shows a flapwise and edgewise blade test in progress.

  18. Prior Experiences Shaping Family Science Conversations at a Nature Center

    ERIC Educational Resources Information Center

    McClain, Lucy R.; Zimmerman, Heather Toomey

    2014-01-01

    Using families as the analytical focus, this study informs the field of informal science education with a focus on the role of prior experiences in family science conversations during nature walks at an outdoor-based nature center. Through video-based research, the team analyzed 16 families during walks at a nature center. Each family's prior…

  19. A Visual Analytics Agenda

    SciTech Connect

    Thomas, James J.; Cook, Kristin A.

    2006-01-01

    The September 11, 2001 attacks on the World Trade Center and the Pentagon were a wakeup call to the United States. The Hurricane Katrina disaster in August 2005 provided yet another reminder that unprecedented disasters can and do occur. And when they do, we must be able to analyze large amounts of disparate data in order to make sense of exceedingly complex situations and save lives. Responding to an Urgent Need This need to support penetrating analysis of massive data collections is not limited to security, though. From systems biology to human health, from evaluations of product effectiveness to strategizing for competitive positioning, to assessing the results of marketing campaigns, there is a critical need to analyze very large amounts of complex information. Simply put, our ability to collect data far outstrips our ability to analyze the data we have collected. Following the September 11 attacks, the government initiated efforts to evaluate the technologies that are available today or are on the near horizon. Two National Academy of Sciences reports identified serious gaps in the technologies. Making the Nation Safer [Alberts & Wulf, 2002] describes how science and technology can be advanced to protect the nation against terrorism. Information Technology for Counterterrorism [Hennessy et al., 2003] expands upon the work of Making the Nation Safer, focusing specifically on the opportunities for information technology to help counter and respond to terrorist attacks. Significant research progress has been made in disciplines such as scientific and information visualization, statistically-based exploratory and confirmatory analysis, data and knowledge representations, and perceptual and cognitive sciences, However, the research community has not adequately addressed the integration of these subspecialties to advance the ability for analysts to apply their expert human judgment to complex data in pressure-filled situations. Although some research is being done

  20. Analytical Psychology: A Review of a Theoretical Approach and Its Application to Counseling.

    ERIC Educational Resources Information Center

    Ziff, Katherine K.

    Analytical psychology is a field supported by training centers, specially trained analysts, and a growing body of literature. While it receives much recognition, it remains mostly outside the mainstream of counseling and counselor education. This document presents a brief history of analytical psychology and how it has been revisited and renamed…

  1. An analytical model of memristors in plants

    PubMed Central

    Markin, Vladislav S; Volkov, Alexander G; Chua, Leon

    2014-01-01

    The memristor, a resistor with memory, was postulated by Chua in 1971 and the first solid-state memristor was built in 2008. Recently, we found memristors in vivo in plants. Here we propose a simple analytical model of 2 types of memristors that can be found within plants. The electrostimulation of plants by bipolar periodic waves induces electrical responses in the Aloe vera and Mimosa pudica with fingerprints of memristors. Memristive properties of the Aloe vera and Mimosa pudica are linked to the properties of voltage gated K+ ion channels. The potassium channel blocker TEACl transform plant memristors to conventional resistors. The analytical model of a memristor with a capacitor connected in parallel exhibits different characteristic behavior at low and high frequency of applied voltage, which is the same as experimental data obtained by cyclic voltammetry in vivo. PMID:25482769

  2. Solar Technology Center

    SciTech Connect

    Boehm, Bob

    2011-04-27

    The Department of Energy, Golden Field Office, awarded a grant to the UNLV Research Foundation (UNLVRF) on August 1, 2005 to develop a solar and renewable energy information center. The Solar Technology Center (STC) is to be developed in two phases, with Phase I consisting of all activities necessary to determine feasibility of the project, including design and engineering, identification of land access issues and permitting necessary to determine project viability without permanently disturbing the project site, and completion of a National Environmental Policy Act (NEPA) Environmental Assessment. Phase II is the installation of infrastructure and related structures, which leads to commencement of operations of the STC. The STC is located in the Boulder City designated 3,000-acre Eldorado Valley Energy Zone, approximately 15 miles southwest of downtown Boulder City and fronting on Eldorado Valley Drive. The 33-acre vacant parcel has been leased to the Nevada Test Site Development Corporation (NTSDC) by Boulder City to accommodate a planned facility that will be synergistic with present and planned energy projects in the Zone. The parcel will be developed by the UNLVRF. The NTSDC is the economic development arm of the UNLVRF. UNLVRF will be the entity responsible for overseeing the lease and the development project to assure compliance with the lease stipulations established by Boulder City. The STC will be operated and maintained by University of Nevada, Las Vegas (UNLV) and its Center for Energy Research (UNLV-CER). Land parcels in the Eldorado Valley Energy Zone near the 33-acre lease are committed to the construction and operation of an electrical grid connected solar energy production facility. Other projects supporting renewable and solar technologies have been developed within the energy zone, with several more developments in the horizon.

  3. Research and technology at Kennedy Space Center

    NASA Technical Reports Server (NTRS)

    1989-01-01

    As the NASA Center responsible for assembly, checkout, servicing, launch, recovery, and operational support of Space Transportation System elements and payloads, Kennedy Space Center is placing increasing emphasis on the Center's research and technology program. In addition to strengthening those areas of engineering and operations technology that contribute to safer, more efficient, and more economical execution of current mission, the technical tools are developed needed to execute Center's mission relative to future programs. The Engineering Development Directorate encompasses most of the laboratories and other Center resources that are key elements of research and technology program implementation and is responsible for implementation of the majority of the projects in this Kennedy Space Center 1989 Annual Report.

  4. Analytical modeling and experimental verification of vibration-based piezoelectric bimorph beam with a tip-mass for power harvesting

    NASA Astrophysics Data System (ADS)

    Wang, Hongjin; Meng, Qingfeng

    2013-03-01

    Power harvesting techniques that convert vibration energy into electrical energy through piezoelectric transducers show strong potential for powering smart wireless sensor devices in applications of structural health monitoring. This paper presents an analytical model of the dynamic behavior of an electromechanical piezoelectric bimorph cantilever harvester connected with an AC-DC circuit based on the Euler-Bernoulli beam theory and Hamiltonian theorem. A new cantilevered piezoelectric bimorph structure is proposed in which the plug-type connection between support layer and tip-mass ensures that the gravity center of the tip-mass is collinear with the gravity center of the beam so that the brittle fracture of piezoelectric layers can also be avoided while vibrating with large amplitude. The tip-mass is equated by the inertial force and inertial moment acting at the end of the piezoelectric bimorph beam based on D'Alembert's principle. An AC-DC converting circuit soldered with the piezoelectric elements is also taken into account. A completely new analytic expression of the global behavior of the electromechanical piezoelectric bimorph harvesting system with AC-DC circuit under input base transverse excitation is derived. Moreover, an experimental energy harvester is fabricated and the theoretical analysis and experimental results of the piezoelectric harvester under the input base transverse displacement excitation are validated by using measurements of the absolute tip displacement, electric voltage response, electric current response and electric power harvesting.

  5. Distributed Active Archive Center

    NASA Technical Reports Server (NTRS)

    Bodden, Lee; Pease, Phil; Bedet, Jean-Jacques; Rosen, Wayne

    1993-01-01

    The Goddard Space Flight Center Version 0 Distributed Active Archive Center (GSFC V0 DAAC) is being developed to enhance and improve scientific research and productivity by consolidating access to remote sensor earth science data in the pre-EOS time frame. In cooperation with scientists from the science labs at GSFC, other NASA facilities, universities, and other government agencies, the DAAC will support data acquisition, validation, archive and distribution. The DAAC is being developed in response to EOSDIS Project Functional Requirements as well as from requirements originating from individual science projects such as SeaWiFS, Meteor3/TOMS2, AVHRR Pathfinder, TOVS Pathfinder, and UARS. The GSFC V0 DAAC has begun operational support for the AVHRR Pathfinder (as of April, 1993), TOVS Pathfinder (as of July, 1993) and the UARS (September, 1993) Projects, and is preparing to provide operational support for SeaWiFS (August, 1994) data. The GSFC V0 DAAC has also incorporated the existing data, services, and functionality of the DAAC/Climate, DAAC/Land, and the Coastal Zone Color Scanner (CZCS) Systems.

  6. The Satellite Situation Center

    NASA Technical Reports Server (NTRS)

    Teague, M. J.; Sawyer, D. M.; Vette, J. I.

    1982-01-01

    Considerations related to the early planning for the International Magnetospheric Study (IMS) took into account the desirability of an establishment of specific entities for generating and disseminating coordination information for both retrospective and predictive periods. The organizations established include the IMS/Satellite Situation Center (IMS/SSC) operated by NASA. The activities of the SSC are related to the preparation of reports on predicted and actually achieved satellite positions, the response to inquiries, the compilation of information on satellite experiments, and the issue of periodic status summaries. Attention is given to high-altitude satellite services, other correlative satellite services, non-IMS activities of the SSC, a summary of the SSC request activity, and post-IMS and future activities.

  7. The Science of Analytic Reporting

    SciTech Connect

    Chinchor, Nancy; Pike, William A.

    2009-09-23

    The challenge of visually communicating analysis results is central to the ability of visual analytics tools to support decision making and knowledge construction. The benefit of emerging visual methods will be improved through more effective exchange of the insights generated through the use of visual analytics. This paper outlines the major requirements for next-generation reporting systems in terms of eight major research needs: the development of best practices, design automation, visual rhetoric, context and audience, connecting analysis to presentation, evidence and argument, collaborative environments, and interactive and dynamic documents. It also describes an emerging technology called Active Products that introduces new techniques for analytic process capture and dissemination.

  8. Kennedy Space Center (KSC) Mishap Response Plan

    NASA Technical Reports Server (NTRS)

    Scarpa, Philip

    2005-01-01

    KSC Medical Operations, in exercising the KSC Psychological Triage Plan, provided crewmember family support following notification of the Columbia accident. KSC Medical Operations also provided field support in working with FEMA and EPA to assure adequate occupational medicine and environmental health care of KSC workers. In addition, the development of policy and procedures for handling and clearing biohazardous debris material in the KSC reconstruction hangar was prepared and implemented.

  9. Dryden Flight Research Center: Center Overview

    NASA Technical Reports Server (NTRS)

    Ratnayake, Nalin

    2009-01-01

    This viewgraph presentation describes a general overview of Dryden Flight Research Center. Strategic partnerships, Dryden's mission activity, exploration systems and aeronautics research programs are also described.

  10. Analytical effective tensor for flow-through composites

    DOEpatents

    Sviercoski, Rosangela De Fatima

    2012-06-19

    A machine, method and computer-usable medium for modeling an average flow of a substance through a composite material. Such a modeling includes an analytical calculation of an effective tensor K.sup.a suitable for use with a variety of media. The analytical calculation corresponds to an approximation to the tensor K, and follows by first computing the diagonal values, and then identifying symmetries of the heterogeneity distribution. Additional calculations include determining the center of mass of the heterogeneous cell and its angle according to a defined Cartesian system, and utilizing this angle into a rotation formula to compute the off-diagonal values and determining its sign.

  11. A new analytic model for fracture-dominated reservoirs

    SciTech Connect

    Karasaki, K.; Long, J.C.S.; Witherspoon, P.A.

    1988-03-01

    A new analytic model for analyzing well test data from fracture-dominated reservoirs is presented. It is a concentric composite model with a finite-radius well located in the center. In the inner region the flow is assumed to be linear, and in the outer region the flow is assumed to be radial. Solutions are obtained analytically and type curves for ranges of dimensionless parameters are presented. The model can be used to find the extent and the flow parameters of the fractures near the well and the average values for the entire system provided that wellbore-storage effects do not mask the early-time data.

  12. Extreme Ultraviolet Explorer Science Operation Center

    NASA Technical Reports Server (NTRS)

    Wong, G. S.; Kronberg, F. A.; Meriwether, H. D.; Wong, L. S.; Grassi, C. L.

    1993-01-01

    The EUVE Science Operations Center (ESOC) is a satellite payload operations center for the Extreme Ultraviolet Explorer project, located on the Berkeley campus of the University of California. The ESOC has the primary responsibility for commanding the EUVE telescopes and monitoring their telemetry. The ESOC is one of a very few university-based satellite operations facilities operating with NASA. This article describes the history, operation, and advantages of the ESOC as an on-campus operations center.

  13. Student Success Center Toolkit

    ERIC Educational Resources Information Center

    Jobs For the Future, 2014

    2014-01-01

    "Student Success Center Toolkit" is a compilation of materials organized to assist Student Success Center directors as they staff, launch, operate, and sustain Centers. The toolkit features materials created and used by existing Centers, such as staffing and budgeting templates, launch materials, sample meeting agendas, and fundraising…

  14. Opportunities Center. Concept Paper.

    ERIC Educational Resources Information Center

    Kimeldorf, Martin

    The opportunities center is a new school service concept that can help students find opportunities related to their talents and interests in work, education, leisure, small business, or community service. The opportunities center model expands the career center model into an information search center offering multiple services that link academic…

  15. Trends in Analytical Scale Separations.

    ERIC Educational Resources Information Center

    Jorgenson, James W.

    1984-01-01

    Discusses recent developments in the instrumentation and practice of analytical scale operations. Emphasizes detection devices and procedures in gas chromatography, liquid chromatography, electrophoresis, supercritical fluid chromatography, and field-flow fractionation. (JN)

  16. Liposomes: Technologies and Analytical Applications

    NASA Astrophysics Data System (ADS)

    Jesorka, Aldo; Orwar, Owe

    2008-07-01

    Liposomes are structurally and functionally some of the most versatile supramolecular assemblies in existence. Since the beginning of active research on lipid vesicles in 1965, the field has progressed enormously and applications are well established in several areas, such as drug and gene delivery. In the analytical sciences, liposomes serve a dual purpose: Either they are analytes, typically in quality-assessment procedures of liposome preparations, or they are functional components in a variety of new analytical systems. Liposome immunoassays, for example, benefit greatly from the amplification provided by encapsulated markers, and nanotube-interconnected liposome networks have emerged as ultrasmall-scale analytical devices. This review provides information about new developments in some of the most actively researched liposome-related topics.

  17. Laboratory Workhorse: The Analytical Balance.

    ERIC Educational Resources Information Center

    Clark, Douglas W.

    1979-01-01

    This report explains the importance of various analytical balances in the water or wastewater laboratory. Stressed is the proper procedure for utilizing the equipment as well as the mechanics involved in its operation. (CS)

  18. Analytic Methods in Investigative Geometry.

    ERIC Educational Resources Information Center

    Dobbs, David E.

    2001-01-01

    Suggests an alternative proof by analytic methods, which is more accessible than rigorous proof based on Euclid's Elements, in which students need only apply standard methods of trigonometry to the data without introducing new points or lines. (KHR)

  19. Analytical Chemistry: A Literary Approach.

    ERIC Educational Resources Information Center

    Lucy, Charles A.

    2000-01-01

    Provides an anthology of references to descriptions of analytical chemistry techniques from history, popular fiction, and film which can be used to capture student interest and frame discussions of chemical techniques. (WRM)

  20. Cautions Concerning Electronic Analytical Balances.

    ERIC Educational Resources Information Center

    Johnson, Bruce B.; Wells, John D.

    1986-01-01

    Cautions chemists to be wary of ferromagnetic samples (especially magnetized samples), stray electromagnetic radiation, dusty environments, and changing weather conditions. These and other conditions may alter readings obtained from electronic analytical balances. (JN)

  1. From Teacher to Day Care Center Director!

    ERIC Educational Resources Information Center

    De Viteri, Jorge Saenz

    This paper addresses the roles and responsibilities of a day care center director, based on the author's personal experience as an interim director during his junior year at college and a survey of other directors. The paper aims to provide insight into the reality of being a day care center director, particularly the acquisition of knowledge,…

  2. How to Start a Rape Crisis Center.

    ERIC Educational Resources Information Center

    Rape Crisis Center, Washington, DC.

    This booklet, written in response to requests from throughout the nation about how a rape crisis center can be started, presents the history of the founding of the Washington, D.C. center. The booklet offers sections dealing with specific issues. A section discusses, for the rape victim, pros and cons of working with the police, together with the…

  3. About the Atmospheric Science Data Center (ASDC)

    Atmospheric Science Data Center

    2016-06-03

    The Atmospheric Science Data Center (ASDC) at NASA Langley Research Center is responsible for the processing, archival, and distribution of NASA Earth science data in the areas of radiation budget, clouds, aerosols, and ... Earth Observing System (EOS) as part of NASA's Earth Science enterprise and the U.S. Global Change Research Program , and is ...

  4. A Client Centered Approach to Job Placement

    ERIC Educational Resources Information Center

    Salomone, Paul R.

    1971-01-01

    A client centered placement approach for handicapped people is proposed as an alternative to the traditional selective placement method. The client centered placement is based on client responsibility and counselor direction and requires the counselor to have an unrealistic but optimistic attitude that the client will get a suitable job.…

  5. Analytical and micromagnetic study of a Néel domain wall

    NASA Astrophysics Data System (ADS)

    Rivkin, K.; Romanov, K.; Abanov, Ar.; Adamov, Y.; Saslow, W. M.

    2008-06-01

    For ferromagnets with exchange, dipolar interaction, and uniaxial anisotropy, by both analytic methods and micromagnetic simulations we study Néel domain walls in thin ferromagnetic strips of finite width. Comparison of the numerical results with the analytics yields parameter values that had been unspecified by the analytics, and determines the modifications needed to describe the magnetization both near the strip center and near the boundaries. With no uniaxial anisotropy, the domain wall center can be described by the same hyperbolic secant form as with uniaxial anisotropy, but the effective anisotropy constant must now be thought of as increasing with increasing film thickness and decreasing with increasing film width.

  6. Functionalized magnetic nanoparticle analyte sensor

    DOEpatents

    Yantasee, Wassana; Warner, Maryin G; Warner, Cynthia L; Addleman, Raymond S; Fryxell, Glen E; Timchalk, Charles; Toloczko, Mychailo B

    2014-03-25

    A method and system for simply and efficiently determining quantities of a preselected material in a particular solution by the placement of at least one superparamagnetic nanoparticle having a specified functionalized organic material connected thereto into a particular sample solution, wherein preselected analytes attach to the functionalized organic groups, these superparamagnetic nanoparticles are then collected at a collection site and analyzed for the presence of a particular analyte.

  7. Visual Analytics Technology Transition Progress

    SciTech Connect

    Scholtz, Jean; Cook, Kristin A.; Whiting, Mark A.; Lemon, Douglas K.; Greenblatt, Howard

    2009-09-23

    The authors provide a description of the transition process for visual analytic tools and contrast this with the transition process for more traditional software tools. This paper takes this into account and describes a user-oriented approach to technology transition including a discussion of key factors that should be considered and adapted to each situation. The progress made in transitioning visual analytic tools in the past five years is described and the challenges that remain are enumerated.

  8. Analytical multikinks in smooth potentials

    NASA Astrophysics Data System (ADS)

    de Brito, G. P.; Correa, R. A. C.; de Souza Dutra, A.

    2014-03-01

    In this work we present an approach that can be systematically used to construct nonlinear systems possessing analytical multikink profile configurations. In contrast with previous approaches to the problem, we are able to do it by using field potentials that are considerably smoother than the ones of the doubly quadratic family of potentials. This is done without losing the capacity of writing exact analytical solutions. The resulting field configurations can be applied to the study of problems from condensed matter to braneworld scenarios.

  9. Resumenes Analiticos en Education del 0001 al 0230 (Analytic Resumes in Education, from 0001 to 0230).

    ERIC Educational Resources Information Center

    Scott, Patrick B., Ed.

    1991-01-01

    REDUC is a cooperative network of some 23 associated centers in 17 Latin American and Caribbean countries. The REDUC coordinating center is located in Santiago, Chile. REDUC produces a bibliographic database containing analytical summaries (approximately 800 items annually) of the most important research studies and project descriptions in the…

  10. Analytical Chemistry Laboratory. Progress report for FY 1996

    SciTech Connect

    Green, D.W.; Boparai, A.S.; Bowers, D.L.

    1996-12-01

    The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1996. This annual report is the thirteenth for the ACL. It describes effort on continuing and new projects and contributions of the ACL staff to various programs at ANL. The ACL operates in the ANL system as a full-cost-recovery service center, but has a mission that includes a complementary research and development component: The Analytical Chemistry Laboratory will provide high-quality, cost-effective chemical analysis and related technical support to solve research problems of our clients -- Argonne National Laboratory, the Department of Energy, and others -- and will conduct world-class research and development in analytical chemistry and its applications. Because of the diversity of research and development work at ANL, the ACL handles a wide range of analytical chemistry problems. Some routine or standard analyses are done, but the ACL usually works with commercial laboratories if our clients require high-volume, production-type analyses. It is common for ANL programs to generate unique problems that require significant development of methods and adaption of techniques to obtain useful analytical data. Thus, much of the support work done by the ACL is very similar to our applied analytical chemistry research.

  11. Analytic study of orbiter landing profiles

    NASA Technical Reports Server (NTRS)

    Walker, H. J.

    1981-01-01

    A broad survey of possible orbiter landing configurations was made with specific goals of defining boundaries for the landing task. The results suggest that the center of the corridors between marginal and routine represents a more or less optimal preflare condition for regular operations. Various constraints used to define the boundaries are based largely on qualitative judgements from earlier flight experience with the X-15 and lifting body research aircraft. The results should serve as useful background for expanding and validating landing simulation programs. The analytic approach offers a particular advantage in identifying trends due to the systematic variation of factors such as vehicle weight, load factor, approach speed, and aim point. Limitations such as a constant load factor during the flare and using a fixed gear deployment time interval, can be removed by increasing the flexibility of the computer program. This analytic definition of landing profiles of the orbiter may suggest additional studies, includin more configurations or more comparisons of landing profiles within and beyond the corridor boundaries.

  12. Preparation of visible-light-responsive TiO2-xNx photocatalyst by a sol-gel method: analysis of the active center on TiO2 that reacts with NH3.

    PubMed

    Kuroda, Yasushige; Mori, Toshinori; Yagi, Kazunori; Makihata, Naoko; Kawahara, Yoichiro; Nagao, Mahiko; Kittaka, Shigeharu

    2005-08-16

    Active reaction centers for ammonia on titanium oxyhydroxide were explored to direct the search for an efficient sol-gel method for the synthesis of a titanium oxynitride (TiO2-xNx) sample with an efficient responsiveness to the visible light constituting a main part of the solar spectrum. The results lead to the conclusion that the site giving IR bands at around 2195 cm(-1) for the adsorbed CO molecules at 300 K is a reactive site and behaves as Lewis acid site in the coordination environment of distorted five-coordinate Ti4+ ions. Ammonia molecules are adsorbed on such a site to form -NH2 and -OH species during the heat treatments at a temperature above 373 K, and they are ultimately incorporated into the TiO2 lattice as nitride through the dehydration at higher temperatures of up to 723 K, resulting in the formation of an anatase type of TiO2-xNx. PMID:16089416

  13. The ASI Science Data Center

    NASA Astrophysics Data System (ADS)

    Gendre, B.; Giommi, P.

    2010-12-01

    The ASI Science Data Center (ASDC, www.asdc.asi.it), a facility of the Italian Space Agency (ASI) is a multi-mission science operations, data processing and data archiving center that provides support to several scientific space missions. At the moment the ASDC has significant responsibilities for a number of high-energy astronomy/astroparticle satellites (e.g. Swift, AGILE, Fermi, NuSTAR and AMS) and supports at different level other missions like, Herschel and Planck. The ASDC was established in 2000 based on the experience built with the management of the BeppoSAX Science Data Center. It is located at the ESA site of ESRIN in Frascati, near Rome (Italy).

  14. The Analytic Information Warehouse (AIW): a Platform for Analytics using Electronic Health Record Data

    PubMed Central

    Post, Andrew R.; Kurc, Tahsin; Cholleti, Sharath; Gao, Jingjing; Lin, Xia; Bornstein, William; Cantrell, Dedra; Levine, David; Hohmann, Sam; Saltz, Joel H.

    2013-01-01

    Objective To create an analytics platform for specifying and detecting clinical phenotypes and other derived variables in electronic health record (EHR) data for quality improvement investigations. Materials and Methods We have developed an architecture for an Analytic Information Warehouse (AIW). It supports transforming data represented in different physical schemas into a common data model, specifying derived variables in terms of the common model to enable their reuse, computing derived variables while enforcing invariants and ensuring correctness and consistency of data transformations, long-term curation of derived data, and export of derived data into standard analysis tools. It includes software that implements these features and a computing environment that enables secure high-performance access to and processing of large datasets extracted from EHRs. Results We have implemented and deployed the architecture in production locally. The software is available as open source. We have used it as part of hospital operations in a project to reduce rates of hospital readmission within 30 days. The project examined the association of over 100 derived variables representing disease and co-morbidity phenotypes with readmissions in five years of data from our institution’s clinical data warehouse and the UHC Clinical Database (CDB). The CDB contains administrative data from over 200 hospitals that are in academic medical centers or affiliated with such centers. Discussion and Conclusion A widely available platform for managing and detecting phenotypes in EHR data could accelerate the use of such data in quality improvement and comparative effectiveness studies. PMID:23402960

  15. Analysis of the Transient Response of a Dual-Fed RC Transmission Line

    PubMed Central

    Dorraki, Mohsen; Cambrell, Gregory K.; Abbott, Derek

    2015-01-01

    The transient analysis of a uniform transmission line of finite length is considered in this paper. For the first time this paper provides an analytical expression for the time-domain response of an RC transmission line, which is stimulated by a step function that is fed into both ends of the transmission line. In particular, we find an analytical expression for the step response at the center of the transmission line, in order to determine the worst-case rise time. This is of interest, for example, in large charge-coupled device (CCD) arrays, where long polysilicon lines are dual-fed in order to mitigate degradation in rise time. The analytical expressions for the RC transmission line are supported by computer-simulated lumped RC models. PMID:25679379

  16. Analytical Chemistry Laboratory Progress Report for FY 1994

    SciTech Connect

    Green, D.W.; Boparai, A.S.; Bowers, D.L.

    1994-12-01

    The purpose of this report is to summarize the activities of the Analytical Chemistry Laboratory (ACL) at Argonne National Laboratory (ANL) for Fiscal Year (FY) 1994 (October 1993 through September 1994). This annual report is the eleventh for the ACL and describes continuing effort on projects, work on new projects, and contributions of the ACL staff to various programs at ANL. The Analytical Chemistry Laboratory is a full-cost-recovery service center, with the primary mission of providing a broad range of analytical chemistry support services to the scientific and engineering programs at ANL. The ACL also has a research program in analytical chemistry, conducts instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL handles a wide range of analytical problems. Some routine or standard analyses are done, but it is common for the Argonne programs to generate unique problems that require significant development of methods and adaption of techniques to obtain useful analytical data. The ACL has four technical groups -- Chemical Analysis, Instrumental Analysis, Organic Analysis, and Environmental Analysis -- which together include about 45 technical staff members. Talents and interests of staff members cross the group lines, as do many projects within the ACL. The Chemical Analysis Group uses wet- chemical and instrumental methods for elemental, compositional, and isotopic determinations in solid, liquid, and gaseous samples and provides specialized analytical services. Major instruments in this group include an ion chromatograph (IC), an inductively coupled plasma/atomic emission spectrometer (ICP/AES), spectrophotometers, mass spectrometers (including gas-analysis and thermal-ionization mass spectrometers), emission spectrographs, autotitrators, sulfur and carbon determinators, and a kinetic phosphorescence uranium analyzer.

  17. Analytical Chemistry Laboratory progress report for FY 1984

    SciTech Connect

    Green, D.W.; Heinrich, R.R.; Jensen, K.J.; Stetter, J.R.

    1985-03-01

    Technical and administrative activities of the Analytical Chemistry Laboratory (ACL) are reported for fiscal year 1984. The ACL is a full-cost-recovery service center, with the primary mission of providing a broad range of technical support services to the scientific and engineering programs at ANL. In addition, ACL conducts a research program in analytical chemistry, works on instrumental and methods development, and provides analytical services for governmental, educational, and industrial organizations. The ACL is administratively within the Chemical Technology Division, the principal user, but provides technical support for all of the technical divisions and programs at ANL. The ACL has three technical groups - Chemical Analysis, Instrumental Analysis, and Organic Analysis. Under technical activities 26 projects are briefly described. Under professional activities, a list is presented for publications and reports, oral presentations, awards and meetings attended. 6 figs., 2 tabs.

  18. Climate Analytics as a Service

    NASA Technical Reports Server (NTRS)

    Schnase, John L.; Duffy, Daniel Q.; McInerney, Mark A.; Webster, W. Phillip; Lee, Tsengdar J.

    2014-01-01

    Climate science is a big data domain that is experiencing unprecedented growth. In our efforts to address the big data challenges of climate science, we are moving toward a notion of Climate Analytics-as-a-Service (CAaaS). CAaaS combines high-performance computing and data-proximal analytics with scalable data management, cloud computing virtualization, the notion of adaptive analytics, and a domain-harmonized API to improve the accessibility and usability of large collections of climate data. MERRA Analytic Services (MERRA/AS) provides an example of CAaaS. MERRA/AS enables MapReduce analytics over NASA's Modern-Era Retrospective Analysis for Research and Applications (MERRA) data collection. The MERRA reanalysis integrates observational data with numerical models to produce a global temporally and spatially consistent synthesis of key climate variables. The effectiveness of MERRA/AS has been demonstrated in several applications. In our experience, CAaaS is providing the agility required to meet our customers' increasing and changing data management and data analysis needs.

  19. Cost and Schedule Analytical Techniques Development

    NASA Technical Reports Server (NTRS)

    1998-01-01

    This Final Report summarizes the activities performed by Science Applications International Corporation (SAIC) under contract NAS 8-40431 "Cost and Schedule Analytical Techniques Development Contract" (CSATD) during Option Year 3 (December 1, 1997 through November 30, 1998). This Final Report is in compliance with Paragraph 5 of Section F of the contract. This CSATD contract provides technical products and deliverables in the form of parametric models, databases, methodologies, studies, and analyses to the NASA Marshall Space Flight Center's (MSFC) Engineering Cost Office (PP03) and the Program Plans and Requirements Office (PP02) and other user organizations. Detailed Monthly Reports were submitted to MSFC in accordance with the contract's Statement of Work, Section IV "Reporting and Documentation". These reports spelled out each month's specific work performed, deliverables submitted, major meetings conducted, and other pertinent information. Therefore, this Final Report will summarize these activities at a higher level. During this contract Option Year, SAIC expended 25,745 hours in the performance of tasks called out in the Statement of Work. This represents approximately 14 full-time EPs. Included are the Huntsville-based team, plus SAIC specialists in San Diego, Ames Research Center, Tampa, and Colorado Springs performing specific tasks for which they are uniquely qualified.

  20. Abramovo Counterterrorism Training Center

    SciTech Connect

    Hayes, Christopher M; Ross, Larry; Lingenfelter, Forrest E; Sokolnikov, Pavel I; Kaldenbach, Karen Yvonne; Estigneev, Yuri; Murievav, Andrey

    2011-01-01

    The U.S. government has been assisting the Russian Federation (RF) Ministry of Defense (MOD) for many years with nuclear weapons transportation security (NWTS) through the provision of specialized guard escort railcars and cargo railcars with integrated physical security and communication systems, armored transport vehicles, and armored escort vehicles. As a natural continuation of the NWTS program, a partnership has been formed to construct a training center that will provide counterterrorism training to personnel in all branches of the RF MOD. The Abramovo Counterterrorism Training Center (ACTC) is a multinational, multiagency project with funding from Canada, RF and the U.S. Departments of Defense and Energy. ACTC will be a facility where MOD personnel can conduct basic through advanced training in various security measures to protect Category IA material against the threat of terrorist attack. The training will enhance defense-in-depth principles by integrating MOD guard force personnel into the overall physical protection systems and improving their overall response time and neutralization capabilities. The ACTC project includes infrastructure improvements, renovation of existing buildings, construction of new buildings, construction of new training facilities, and provision of training and other equipment. Classroom training will be conducted in a renovated training building. Basic and intermediate training will be conducted on three different security training areas where various obstacles and static training devices will be constructed. The central element of ACTC, where advanced training will be held, is the 'autodrome,' a 3 km road along which various terrorist events can be staged to challenge MOD personnel in realistic and dynamic nuclear weapons transportation scenarios. This paper will address the ACTC project elements and the vision for training development and integrating this training into actual nuclear weapons transportation operations.