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Sample records for central incisors based

  1. Relationship of the lingual frenum to the mandibular central incisors

    PubMed Central

    Gupta, Swati; Garg, Sanchit; Tandan, Amrit; Dwivedi, Ravi; Gupta, Narendra Kumar; Agarwal, Garima

    2015-01-01

    Clinical implication The purpose of this study is to record the vertical distance between anterior attachment of lingual frenum and incisal edge of mandibular central incisors in dentulous subjects and then determine the mean vertical distance and to suggest guidelines for positioning of mandibular central incisors in complete dentures. Method In this study, 150 dentulous subjects (75 males and 75 females) were chosen based on predecided inclusion criteria. A mandibular cast was obtained from irreversible hydrocolloid impression in modified stock trays for each subject. All subjects were instructed to elevate the tongue while the impressions were made. The vertical distance between the anterior attachment of the lingual frenum and incisal edges of mandibular central incisors was measured on the casts and then the values were statistically analyzed. Result The distance between anterior attachment of lingual frenum (AALF) mesioincisal edge of mandibular central incisor (CI) in male, female and total (male+female) subjects was measured. In males it ranged from 7.3 to 8.9mm with mean (SD) 8.290.36mm while in females it ranged from 7.1 to 9.0mm with mean (SD) 8.210.38mm. Conclusion It is believed that the application of this anatomic relation can provide a reliable point for arranging and checking the position of the mandibular central incisors for complete dentures in patients with class I ridge relationship. PMID:25853047

  2. Treatment of impacted, rotated central incisors with removable appliance.

    PubMed

    Bayani, Shahin; Hashemi, Zahra; Khoramian, Somaye

    2013-01-01

    A 12-year-old girl was referred to the orthodontic department of Kerman dental school with a chief complaint of two unerupted upper left & right front teeth. Patient had no significant medical & Dental history. Intra oral and radiographic examination revealed missing of two maxillary permanent central incisors. Orthodontic treatment involved two phases: Phase 1 Impacted maxillary central incisors: surgical exposure and force eruption with removable appliance. Phase 2: whip appliance is used to correct rotation of right permanent maxillary incisor. PMID:23941031

  3. Solitary median maxillary central incisor (SMMCI) syndrome

    PubMed Central

    Hall, Roger K

    2006-01-01

    Solitary median maxillary central incisor syndrome (SMMCI) is a complex disorder consisting of multiple, mainly midline defects of development resulting from unknown factor(s) operating in utero about the 35th38th day(s) from conception. It is estimated to occur in 1:50,000 live births. Aetiology is uncertain. Missense mutation in the SHH gene (I111F) at 7q36 may be associated with SMMCI. The SMMCI tooth differs from the normal central incisor, in that the crown form is symmetric; it develops and erupts precisely in the midline of the maxillary dental arch in both primary and permanent dentitions. Congenital nasal malformation (choanal atresia, midnasal stenosis or congenital pyriform aperture stenosis) is positively associated with SMMCI. The presence of an SMMCI tooth can predict associated anomalies and in particular the serious anomaly holoprosencephaly. Common congenital anomalies associated with SMMCI are: severe to mild intellectual disability, congenital heart disease, cleft lip and/or palate and less frequently, microcephaly, hypopituitarism, hypotelorism, convergent strabismus, oesophageal and duodenal atresia, cervical hemivertebrae, cervical dermoid, hypothyroidism, scoliosis, absent kidney, micropenis and ambiguous genitalia. Short stature is present in half the children. Diagnosis should be made by eight months of age, but can be made at birth and even prenatally at 1822 weeks from the routine mid-trimester ultrasound scan. Management depends upon the individual anomalies present. Choanal stenosis requires emergency surgical treatment. Short stature may require growth hormone therapy. SMMCI tooth itself is mainly an aesthetic problem, which is ideally managed by combined orthodontic, prosthodontic and oral surgical treatment; alternatively, it can be left untreated. PMID:16722608

  4. A facial talon cusp on maxillary permanent central incisors

    PubMed Central

    Chinni, Suneelkumar; Nanneboyina, Mayuri; Ramachandran, Anilkumar; Chalapathikumar, Hanuman

    2012-01-01

    Talon cusp is a dental anomaly that occurs as an accessory cusp like structure, from the cingulum of maxillary and mandibular anterior teeth. Lingual location is usually considered pathognomic. This case report discuss about the unusual appearance of talon cusp on the facial surface of the maxillary left permanent central incisor and a mild talon cusp on the facial surface of the maxillary right permanent central incisor. PMID:22368344

  5. Extraction of Maxillary Central Incisors: An Orthodontic-Restorative Treatment

    PubMed Central

    Hedayati, Zohreh; Zare, Maryam; Bahramnia, Fateme

    2014-01-01

    Malformed central incisors with poor prognosis could be candidates for extraction especially in crowded dental arches. This case report refers to a 12-year-old boy who suffered from malformed upper central incisors associated with severe attrition. Upper lateral incisors were positioned palatally and canines were rotated and positioned in the high buccal area. The patient had class II malocclusion and space deficiency in both dental arches. Due to incisal wear and malformed short maxillary central incisors and the need for root canal therapy with a major crown build-up, these teeth were extracted. The maxillary lateral incisors were substituted. Thus the maxillary canines were substituted for lateral incisors and the first premolars were substituted for canines. In the lower dental arch the first bicuspids were extracted. Composite resin build-up was performed on the maxillary lateral incisors and canines. This allowed for the crowding and the malocclusion to be corrected. Subsequent gingivectomy improved the patient's gingival margins and smile esthetics one month after orthodontic therapy. PMID:25400954

  6. Dental transposition of canine and lateral incisor and impacted central incisor treatment: A case report

    PubMed Central

    Gebert, Tarcisio Jacinto; Palma, Vincius Canavarros; Borges, Alvaro Henrique; Volpato, Luiz Evaristo Ricci

    2014-01-01

    Introduction Dental transposition and impaction are disorders related to ectopic eruption or failure in tooth eruption, which can affect child physical, mental and social development and may be difficult to be clinically solved. Methods We describe a case of transposition between the upper left canine and lateral incisor associated with impaction of the central incisor on the same side, in a 12-year-old patient. Conservative treatment involving surgical-orthodontic correction of transposed teeth and traction of the central incisor was conducted. Conclusion The option of correcting transposition and orthodontic traction by means of the segmented arch technique with devices such as cantilever and TMA rectangular wire loops, although a complex alternative, was proved to be esthetically and functionally effective. PMID:24713567

  7. Multidisciplinary approach to a traumatized unerupted dilacerated maxillary central incisor.

    PubMed

    de Oliveira Ruellas, Antônio Carlos; Mattos, Claudia Trindade

    2012-07-01

    A patient with an impacted dilacerated maxillary left central incisor is presented. The 8-year-old girl also presented with protrusion of teeth and lips, posterior crossbite, anterior open bite, thumb-sucking habit, and transposition of the maxillary left lateral incisor and canine. The treatment consisted of a multidisciplinary approach, including surgery, orthodontics, endodontics, and prosthodontics. The dilacerated incisor was surgically exposed, tractioned, endodontically treated, and restored. Four premolars were extracted to correct the protrusion. The outcome was the accomplishment of a balanced and functional occlusion, resulting in a pleasant smile. PMID:22149545

  8. Neonatal nasal obstruction and a single maxillary central incisor.

    PubMed

    Levison, John; Neas, Katherine; Wilson, Meredith; Cooper, Peter; Wojtulewicz, Julian

    2005-07-01

    We present two neonates with nasal obstruction because of anterior choanal stenosis (congenital nasal pyriform aperture stenosis). An associated single maxillary central incisor was also shown on computed tomography imaging in the neonatal period. These midline anomalies are recognized minimal manifestations (microforms) of holoprosencephaly. We describe their neonatal investigation, multidisciplinary management and clinical course. PMID:16014147

  9. Variation in Size and Form between Left and Right Maxillary Central Incisor Teeth

    PubMed Central

    Vadavadagi, Suneel V; Hombesh, M N; Choudhury, Gopal Krishna; Deshpande, Sumith; Anusha, C V; Murthy, D Kiran

    2015-01-01

    Background: To compare the variation in size of left and right maxillary central incisors for male patients (using digital calipers of 0.01 mm accuracy). To compare the variation in size of left and right maxillary central incisors for female patients (using digital calipers of 0.01 mm accuracy). To find out the difference between the maxillary central incisors of men and women. Its clinical applicability if difference exists. Materials and Methods: A total of 70 dental students of PMNM Dental College and Hospital were selected. Of 70 dental students, 40 male and 30 female were selected. Impressions were made for all subjects, using irreversible hydrocolloid (Algitex, manufacturer DPI, Batch-T-8804) using perforated stock metal trays. The mesiodistal crown width and cervical width were measured for each incisor and recorded separately for left and right teeth. The length was measured for each incisor and recorded separately for left and right maxillary central incisor using digitec height caliper. Results: The mean value of maximum crown length of maxillary left central incisor of male was greater in length compared with maxillary right central incisor. Mean value of maximum crown length for male patient right and left side was greater compared with maximum crown length of female patient. Conclusion: When compared the dimensions of teeth between two sex, male group shows larger values to female group. PMID:25859104

  10. Alveolar bone thickness around maxillary central incisors of different inclination assessed with cone-beam computed tomography

    PubMed Central

    Liu, Fang; Sun, Hong-jing; Lv, Pin; Cao, Yu-ming; Yu, Mo; Yue, Yang

    2015-01-01

    Objective To assess the labial and lingual alveolar bone thickness in adults with maxillary central incisors of different inclination by cone-beam computed tomography (CBCT). Methods Ninety maxillary central incisors from 45 patients were divided into three groups based on the maxillary central incisors to palatal plane angle; lingual-inclined, normal, and labial-inclined. Reformatted CBCT images were used to measure the labial and lingual alveolar bone thickness (ABT) at intervals corresponding to every 1/10 of the root length. The sum of labial ABT and lingual ABT at the level of the root apex was used to calculate the total ABT (TABT). The number of teeth exhibiting alveolar fenestration and dehiscence in each group was also tallied. One-way analysis of variance and Tukey's honestly significant difference test were applied for statistical analysis. Results The labial ABT and TABT values at the root apex in the lingual-inclined group were significantly lower than in the other groups (p < 0.05). Lingual and labial ABT values were very low at the cervical level in the lingual-inclined and normal groups. There was a higher prevalence of alveolar fenestration in the lingual-inclined group. Conclusions Lingual-inclined maxillary central incisors have less bone support at the level of the root apex and a greater frequency of alveolar bone defects than normal maxillary central incisors. The bone plate at the marginal level is also very thin. PMID:26445719

  11. Influence of prefabricated post dimensions on restored maxillary central incisors.

    PubMed

    Rodrguez-Cervantes, P J; Sancho-Bru, J L; Barjau-Escribano, A; Forner-Navarro, L; Prez-Gonzlez, A; Snchez-Marn, F T

    2007-02-01

    The aim of this study was to test the following hypothesis: biomechanical performance (fracture strength and stress distribution) of restored teeth is less sensitive to post diameter and post length when using glass fibre posts than when using stainless steel posts. First, an experimental fracture strength test was performed on 80 extracted human maxillary central incisors. Teeth were decoronated, treated endodontically and restored (40 with glass fibre posts and 40 with stainless steel posts), and the length and diameter of the posts varied uniformly. Failure loads were recorded and results were compared using an ancova analysis. Secondly, the finite element technique was used to develop a model of the restored tooth. The post diameter had a significant effect on the biomechanical performance of teeth restored with stainless steel posts. Lower failure loads were found as post diameter increased. However, the post diameter of those teeth restored with glass fibre posts, and the post length for both post systems under consideration, did not affect the biomechanical performance of restored teeth to a significant degree. The stress distributions predicted by the developed model corroborated these findings, confirmed the assumed hypothesis, and permitted the proposal of the use of glass fibre posts to achieve a restorative technique that is less sensitive to post dimensions, and thus more robust. PMID:17244237

  12. Premolar transplantation in a patient with solitary median maxillary central incisor syndrome.

    PubMed

    Pseiner, Bernhard C

    2014-12-01

    This case report describes the orthodontic treatment of an 11-year-old girl with solitary median maxillary central incisor syndrome, a presumed microform of holoprosencephaly. Because both second premolars were missing in the maxilla, deciduous molar extraction and orthodontic space opening were performed, moving the solitary median maxillary central incisor electively off-center. A mandibular second premolar was transplanted to replace the missing incisor. The resulting spaces could be orthodontically closed in both arches. Prosthodontic reshaping of the transplanted tooth after debonding completed the dental treatment. PMID:25432260

  13. Triple-X syndrome accompanied by single maxillary central incisor: case report.

    PubMed

    Miura, M; Kato, N; Kojima, H; Oguchi, H

    1993-01-01

    Facial, oral, and dental findings of an 11-year-old girl with XXX syndrome are reported. Clinical examination reveals midfacial hypoplasia, congenital absence of teeth, and solitary maxillary central incisors both in primary and permanent dentitions. PMID:8378162

  14. Correction of a severely rotated maxillary central incisor with the Whip device.

    PubMed

    Bayani, Shahin; Khoramian, Somayeh

    2011-01-01

    The following case report presents an appliance named Whip device used for the correction of severe rotations of anterior teeth in pre-adolescent patient. A 9-year-old boy with a severe 90 degrees rotation of upper left central incisor was treated with a Whip appliance. After 3 months of treatment, the position of the upper left central incisor was orthodontically corrected. PMID:22360076

  15. Avulsed Immature Permanent Central Incisors Obturated With Mineral Trioxide Aggregate: A Case Report

    PubMed Central

    Al-Kahtani, Ahmed

    2013-01-01

    The endodontic management of immature permanent incisors in young children can be challenging. This case reported an avulsed immature maxillary central incisors that underwent complete endodontic obturation using mineral trioxide aggregate. A 10-year-old male who suffered a fall injury avulsed both his central incisors. The revascularization process was not possible due to patient compliance and geographic reasons. Mineral trioxide aggregate was utilized as a novel endodontic treatment. After one year post-injury, the teeth remained symptom-free, the clinical and radiographic follow-up showed evidence of healthy periodontium. How to cite this article: Al-Kahtani A. Avulsed Immature Permanent Central Incisors Obturated With Mineral Trioxide Aggregate: A Case Report. J Int Oral Health 2013; 5(3):88-96. PMID:24155609

  16. Movement of an upper central incisor across the midline in a patient with cleft of primary palate.

    PubMed

    Manosudprasit, Montian; Wangsrimongkol, Tasanee; Pisek, Poonsak; Chittiwatanapong, Nisa

    2013-09-01

    Orthodontic treatment for a 10-years-old girl, with repaired bilateral cleft lip and left incomplete unilateral alveolar cleft, was performed by moving her right maxillary central incisor across the midline to replace her congenital missing central incisor and then moving the right lateral incisor toward the midline to act as a new central incisor. A malformed supernumerary tooth, positioned between the right central and lateral incisor, was extracted during incisor movement. Significant lip profile improvement was accomplished by maxillary and mandibular anterior teeth retraction into three-premolar extraction spaces. Not only natural functional occlusion, deviated midpalatal suture along the central incisor, and no obvious root resorption were obtained but also narrowing the alveolar bone cleft which was beneficial for bone continuity supporting dental structures, satisfactory results were possible for the patient with primary palate cleft. PMID:24386757

  17. Fracture resistance of upper central incisors restored with different posts and cores

    PubMed Central

    Rezaei Dastjerdi, Maryam; Amirian Chaijan, Kamran

    2015-01-01

    Objectives To determine and compare the fracture resistance of endodontically treated maxillary central incisors restored with different posts and cores. Materials and Methods Forty-eight upper central incisors were randomly divided into four groups: cast post and core (group 1), fiber-reinforced composite (FRC) post and composite core (group 2), composite post and core (group 3), and controls (group 4). Mesio-distal and bucco-lingual dimensions at 7 and 14 mm from the apex were compared to ensure standardization among the groups. Twelve teeth were prepared for crown restoration (group 4). Teeth in other groups were endodontically treated, decoronated at 14 mm from the apex, and prepared for posts and cores. Resin-based materials were used for cementation in groups 1 and 2. In group 3, composite was used directly to fill the post space and for core build-up. All samples were restored by standard metal crowns using glass ionomer cement, mounted at 135° vertical angle, subjected to thermomechanical aging, and then fractured using a universal testing machine. Kruskal-Wallis and Mann-Whitney U tests were used to analyze the data. Results Fracture resistance of the groups was as follows: Control (group 4) > cast post and core (group 1) > fiber post and composite core (group 2) > composite post and core (group 3). All samples in groups 2 and 3 fractured in restorable patterns, whereas most (58%) in group 1 were non-restorable. Conclusions Within the limitations of this study, FRC posts showed acceptable fracture resistance with favorable fracture patterns for reconstruction of upper central incisors. PMID:26295027

  18. Clinical and radiographic evaluation of maxillary central incisors exposure in patients undergoing maxillary advancement

    PubMed Central

    Trento, Guilherme dos Santos; Bernab, Felipe Bueno Rosettti; da Costa, Delson Joo; Rebellato, Nelson Luis Barbosa; Klppel, Leandro Eduardo; Scariot, Rafaela

    2015-01-01

    Abstract Introduction: Patients with dentofacial deformities may undergo orthodontic or orthodontic-surgical treatment. Both modalities can affect esthetics. Objective: This study aims to evaluate clinical and radiographic changes in exposure of maxillary central incisors occurring after orthognathic surgery for maxillary advancement. Methods: A total of 17 patients who underwent orthognathic surgery for maxillary advancement between September, 2010 and July, 2011 were selected. Exposure of maxillary central incisors was evaluated clinically and by lateral cephalograms. Measurements were taken one week before and three months after surgery. Data were paired in terms of sex, age, nasolabial angle, height and thickness of the upper lip, the amount of maxillary advancement, clinical exposure and inclination of maxillary central incisor by statistical tests (CI 95%). Results: After maxillary advancement, incisor clinical exposure had increased even with relaxed lips and under forced smile. Moreover, there was a mean increase of 23.33% revealed by lateral cephalograms. There was an inverse correlation between upper lip thickness and incisors postsurgical exposure revealed by radiographic images (p = 0.002). Conclusions: Significant changes in the exposure of maxillary central incisors occur after maxillary advancement, under the influence of some factors, especially lip thickness. PMID:26691970

  19. Innovative biomechanics for orthodontic correction of torsiversion of maxillary central incisor caused by twin mesiodens

    PubMed Central

    Monga, Nitika; Kharbanda, Om Prakash; Duggal, Ritu

    2014-01-01

    Mesiodens is the most common type of supernumerary teeth found in the premaxilla between the two central incisors. Early and proper diagnosis and appropriate treatment plan is critical in eluding the extent of treatment needed. This case report presents the successful orthodontic and esthetic management of an unusual case of Indian origin with twin mesiodens in the maxillary arch causing torsiversion and attrition of mandibular incisors due to occlusal trauma. PMID:24963264

  20. Rehabilitation of the dominance of maxillary central incisors with refractory porcelain veneers requiring minimal tooth preparation.

    PubMed

    da Cunha, Leonardo Fernandes; Gonzaga, Carla Castiglia; Saab, Rafaella; Mushashe, Amanda Mahammad; Correr, Gisele Maria

    2015-01-01

    Central dominance is an important element of an esthetic smile. Color, form, and size have been suggested as tools for assessing the dominance of maxillary teeth. A spectrophotometer can be used to determine the value, hue, and chroma. Correct sizing of restorations according to the central incisor dominance principle improves not only esthetics but also aspects of occlusion, such as anterior guidance. Refractory porcelain systems can effectively restore the color, shape, emergence profile, and incisal translucency. This report illustrates the esthetic and occlusal rehabilitation of the dominance of maxillary central incisors using fabricated minimal thickness refractory porcelain veneers. PMID:26345102

  1. Solitary median maxillary central incisor: A case report of a rare dental anomaly

    PubMed Central

    Chandrasekaran, Deepak; Yezdani, Arif; Tajir, Faizal; Saravanan, B.; Rajasekar, L.

    2015-01-01

    The solitary median maxillary central incisor (SMMCI) syndrome is a rare dental anomaly and has an incidence of 1:50,000 live births. In SMMCI, there is only one central incisor present, and it develops exactly at the midline. SMMCI occurrence has been described with growth hormone deficiency or other structural anomalies in the midline of the body. In this case, the 8-year-old female patient reported a single median maxillary central incisor with missing maxillary and mandibular frena, with apparently no other abnormalities. Early diagnosis and recognition of SMMCI are important for all practicing Orthodontists, as it may be a sign of other severe congenital or developmental abnormalities. PMID:26015739

  2. Peripheral odontogenic fibroma associated with a dilacerated maxillary central incisor: a case report.

    PubMed

    Ramachandra, Srinivas Sulugodu; Baliga, Vidya; Prasad, Umesh Chandra

    2011-10-01

    The authors report a case of a 16-year-old male with peripheral odontogenic fibroma (POF) in the anterior maxilla associated with dilaceration of a tooth in its vicinity. A solitary, exophytic and sessile growth was present between the maxillary right central and lateral incisors and extended from the labial mucosa to the palatal gingiva. A periapical radiograph of the maxillary right central incisor revealed a shortened and dilacerated root. The growth was excised and sent for histopathologic examination. A diagnosis of POF (World Health Organization type) was rendered. The clinical and microscopic features are discussed. PMID:23738522

  3. Bilateral presence of two root canals in maxillary central incisors: A rare case study

    PubMed Central

    Kavitha, M.; Gokul, Kannan; Ramaprabha, B.; Lakshmi, Amudha

    2014-01-01

    Success in root canal treatment is achieved after thorough cleaning and shaping followed by complete obturation of the canal system. Therefore, endodontic therapy requires specific and complete knowledge of the internal and external dental anatomy, and its variations in presentation. The internal anatomy of the maxillary central incisor is well-known and usually presents one root canal system. This case report describes an endodontic treatment of traumatized both maxillary central incisors with two canal systems. Knowledge of dental anatomy is fundamental for proper endodontic practice. When root canal treatment is performed, the clinician should be aware that both external and internal anatomy may be abnormal. PMID:24963266

  4. An unusual case of compound odontome associated with maxillary impacted central incisor

    PubMed Central

    Khan, Nadia; Shrivastava, Neha; Shrivastava, Tarun Vijay; Samadi, Fahad Mansoor

    2014-01-01

    Odontomas are the most common type of odontogenic tumor occurring within the jaws and are frequently associated with the retained deciduous teeth interfering with the eruption of permanent teeth. Compound odontomas are usually diagnosed in the anterior portion of the jaws and resemble tooth-like structure. These are usually asymptomatic. Complex odontomas are normally diagnosed in the posterior part of the jaws and consist of a disorganized mass with no morphologic resemblance to a tooth. The present case report of a 16-year-old female is a typical case of compound odontoma in the maxillary anterior region associated with retained deciduous incisor, which also resulted in failure of eruption of the permanent maxillary right central incisor. An intraoral periapical radiograph revealed the presence of a radio-opaque tooth-like structure in the apical region of retained deciduous incisor and an impacted permanent right central incisor whose path of eruption was impeded by the structure. Treatment included the surgical removal of the lesion followed by orthodontic extrusion of the impacted incisor. Follow-up was done for one 1 year and no recurrence was seen. PMID:25937733

  5. A new computational method for automatic dental measurement: The case of maxillary central incisor.

    PubMed

    Di Angelo, L; Di Stefano, P; Bernardi, S; Continenza, M A

    2016-03-01

    This paper proposes a new automatic approach to determine the accurate measure of human teeth. The aim of the proposed computer based method is to reduce inaccuracy of measurement with respect to traditional approaches. Starting from a 3D model of the teeth which is obtained from 3D scanning, the method algorithmically evaluates the most important dimensional features detectable in central incisors. For this purpose, specific rules are put forward and implemented in original software with a view to identifying repere points, from which to detect dimensional features both unambiguously and accurately. The automatic method which is proposed here is verified by means of the analysis of real teeth and is then compared with the current state-of-the-art methods for teeth measurement. PMID:26851728

  6. A Global Numerical analysis of the "central incisor/local maxillary bone" system using a meshless method.

    PubMed

    Moreira, S F; Belinha, J; Dinis, L M J S; Jorge, R M Natal

    2014-09-01

    In this work the maxillary central incisor is numerically analysed with an advance discretization technique--Natural Neighbour Radial Point Interpolation Method (NNRPIM). The NNRPIM permits to organically determine the nodal connectivity, which is essential to construct the interpolation functions. The NNRPIM procedure, based uniquely in the computational nodal mesh discretizing the problem domain, allows to obtain autonomously the required integration mesh, permitting to numerically integrate the differential equations ruling the studied physical phenomenon. A numerical analysis of a tooth structure using a meshless method is presented for the first time. A two-dimensional model of the maxillary central incisor, based on the clinical literature, is established and two distinct analyses are performed. First, a complete elasto-static analysis of the incisor/maxillary structure using the NNRPIM is evaluated and then a non-linear iterative bone tissue remodelling analysis of the maxillary bone, surrounding the central incisive, is performed. The obtained NNRPIM solutions are compared with other numerical methods solutions available in the literature and with clinical cases. The results show that the NNRPIM is a suitable numerical method to analyse numerically dental biomechanics problems. PMID:25831859

  7. Treatment of severe rotations of maxillary central incisors with whip appliance: Report of three cases.

    PubMed

    Parisay, Iman; Boskabady, Marzie; Abdollahi, Mojtaba; Sufiani, Mostafa

    2014-01-01

    The routine treatment for rotated maxillary incisor is a fixed appliance, but in some instance the use of this method is impossible. In addition, in only limited cases of rotation, removable appliance is applicable. In this study, the use of a semi-removable appliance is presented, which has some benefits over the other methods. In this study, the corrections of about 70-90° rotation of the maxillary central incisors in different phases of mixed dentition were performed in three patients using whip appliance. This method was performed using a simple removable appliance such as Hawley appliance and whip spring that forced the couple to derotate the tooth. In all cases, treatment was successfully completed in relative short duration. Whip appliance can be recommended as an effective method to correct rotation of maxillary incisor in mixed dentition with several advantages like rapid correction. PMID:24688574

  8. A three-dimensional finite-element stress analysis of an endodontically prepared maxillary central incisor.

    PubMed

    Ricks-Williamson, L J; Fotos, P G; Goel, V K; Spivey, J D; Rivera, E M; Khera, S C

    1995-07-01

    This study is an application of a three-dimensional Finite-Element Method to investigate the changes in stress characteristics of a prepared maxillary central incisor. The purpose of this study was to analyze stress distributions in this tooth after simulated canal preparation and static loading. A maxillary central incisor was embedded in acrylic, sectioned, photographed, and digitized. A three-dimensional finite-element model was generated by a computer and appropriately modified to simulate canal preparation. Data identified the highest stress magnitudes to be located between the middle and coronal thirds of the root; an area clinically observed to be prone to fracture during treatment. In addition, the magnitude of generated stresses was directly correlated with the simulated prepared canal diameter. The development of a validated three-dimensional finite-element method could identify areas that may predispose a tooth to structural failure during condensation loads. PMID:7499976

  9. Treatment of Class II open bite complicated by an ankylosed maxillary central incisor.

    PubMed

    Hwang, Dong-Hyun; Park, Ki-Ho; Kwon, Yong-Dae; Kim, Su-Jung

    2011-07-01

    Ankylosed teeth in growing patients cause troublesome dentoalveolar problems and require special therapeutic care for accomplishing long-term esthetic and functional results. The various treatment modalities for ankylosed teeth include reconstruction after extraction, surgical extrusive luxation, individual segmental osteotomy or corticotomy, and alveolar distraction osteogenesis. This report describes a case of a 13-year-old boy with anterior open bite complicated by an ankylosed maxillary central incisor that was managed by corticotomy-facilitated orthodontic treatment. PMID:21341998

  10. Surgical management of iatrogenic perforation in maxillary central incisor using mineral trioxide aggregate

    PubMed Central

    Nagpal, Rajni; Manuja, Naveen; Pandit, I K; Rallan, Mandeep

    2013-01-01

    Root perforations are undesired complications of endodontic treatment. The repair of root perforation can be accomplished using different materials and techniques. Mineral trioxide aggregate (MTA) is widely used to seal perforations because of its biocompatibility and sealability. This article describes a case report where an iatrogenic root perforation was repaired successfully with MTA in maxillary right central incisor of a 13-year-old boy. PMID:23845686

  11. Management of a Central Incisor with Horizontal Root Fracture for Esthetic and Functional Rehabilitation.

    PubMed

    Jepsen, Karin; Schneider, Eva; Dommisch, Henrik; Jepsen, Søren

    2016-01-01

    Severely traumatized incisors in young adults are a very common problem, and one that is difficult to treat because healing of these teeth is not always predictable and implant placement has to be delayed until adulthood. This case report of a horizontal root fracture in an avulsed central incisor illustrates the ability to maintain crucial tooth structure. A lateral socket augmentation procedure after extraction of a root fragment combined with an endodontic and regenerative periodontal treatment approach could preserve natural esthetics and function, which are directly related to quality of life. The preservation of alveolar bone volume following partial root removal will eventually facilitate later placement of a dental implant with an improved esthetic and functional prosthodontic result in a patient with a high-risk esthetic profile. PMID:26697554

  12. Management of a Horizontally Impacted and Dilacerated Central Incisor in the Early Mixed Dentition.

    PubMed

    Dave, Heemanshu R; Samrit, Vilas D; Duggal, Ritu; Kharbanda, Om Prakash

    2015-01-01

    An impacted maxillary incisor in the early mixed dentition can pose a clinical challenge for orthodontists and pediatric dentists. Clinical observations supported with a 3-D imaging technique can help not only in assessing the precise location of the impacted tooth and its relation with neighboring teeth but also in correctly executing a treatment plan. The purpose of this paper is to describe the management of a severely rotated and horizontally impacted central incisor using intrabony rotation and simultaneous orthodontically-guided eruption. Timely intervention avoided disturbance in arch integrity and meticulous management helped to produce an excellent outcome in terms of function, esthetics, and stability of occlusion during two years of follow-up. PMID:26731253

  13. Morphometric analysis of pulp size in maxillary permanent central incisors correlated with age: An indirect digital study

    PubMed Central

    Ravindra, S. V.; Mamatha, G. P.; Sunita, J. D.; Balappanavar, Aswini Y.; Sardana, Varun

    2015-01-01

    Context: Teeth are hardest part of the body and are least affected by the taphonomic process. They are considered as one of the reliable methods of identification of a person in forensic sciences. Aim: The aim of the following study is to establish morphometeric measurements by AutoCad 2009 (Autodesk, Inc) of permanent maxillary central incisors in different age groups of Udaipur population. Setting and Design: Hospital-based descriptive cross-sectional study carried out in Udaipur. Materials and Methods: A study was carried out on 308 subjects of both genders with the age range of 9-68 years. Standardized intra-oral radiographs were made by paralleling technique and processed. The radiographs were scanned and the obtained images were standardized to the actual size of radiographic film. This was followed by measuring them using software AutoCad 2009. Statistical Analysis Used: F-test, post-hoc test, Pearson's correlation test. Results: For left maxillary central incisor, the total pulp area was found to be of 38.41 ± 12.88 mm and 14.32 ± 7.04 mm respectively. For right maxillary central incisor, the total pulp size was 38.39 ± 14.95 mm and 12.35 ± 5 mm respectively. Males (32.50, 32.87 mm2) had more pulp area when compared with females (28.82, 30.05 mm2). Conclusion: There was a decrease in total pulp area with increasing age which may be attributed to secondary dentin formation. PMID:26816461

  14. The non-vital discolored central incisor dilemma.

    PubMed

    Schlichting, Lus Henrique; Stanley, Kyle; Magne, Michel; Magne, Pascal

    2015-01-01

    The restoration of anterior teeth is frequently a demanding mission. Patients generally have high expectations for the anterior region, which makes the emotional side of treatment especially important. When this involves discolored endodontically treated teeth, consensus can hardly ever be found as to the chosen approach. Bleaching with direct composites is undoubtedly the most conservative choice for these cases. However, this may require more maintenance (touch-up bleaching and repairs) in the long term, which is an important issue for adult patients. On the other hand, bonded porcelain veneers represent a more 'high-end' option, as they recover the original biomechanics of the intact tooth, allow an optimal masking of the substrate, remain stable, and have a reasonable biological cost when compared to full-coverage crowns. This strategy is explained in this article and documented with a clinical case. We describe treatment planning based on the biomimetic concept, taking into consideration what is possible with current materials and techniques when combined with the patient's particular needs, including the introduction of an innovative step during dentin sealing--the microsuction. The laboratory work was totally accomplished by 'teledentistry', with no direct contact between the dental technologist and the patient. PMID:26794051

  15. Esthetic and functional rehabilitation of a severely compromised central incisor: an interdisciplinary approach.

    PubMed

    Jepsen, Karin; Jaeger, Andreas; Jepsen, Sren

    2015-01-01

    This case report of a patient with a central incisor with rapid destruction of periodontal tissues associated with pathologic tooth migration illustrates the esthetic and functional reconstruction of a severely compromised tooth. An interdisciplinary approach, including resolution of the infection and regenerative periodontal surgery followed by orthodontic tooth movement, transformed a hopeless tooth with high mobility, attachment loss approaching the apex, and a Miller Class IV recession into a clinically healthy tooth. Treatment planning for periodontally involved anterior teeth with pathologic migration should consider a multidisciplinary approach for preservation of the natural dentition. PMID:25909531

  16. Maturogenesis of Two Maxillary Central Incisors: A Case Report with 10 Years of Follow Up

    PubMed Central

    Ghorbanzadeh, Abdollah

    2015-01-01

    This case report describes the treatment of two immature maxillary central incisors in a 7-year-old female patient. She suffered complicated crown fracture because of trauma, and the root formation was incomplete. White mineral trioxide aggregate (MTA) was selected as the pulp-capping material after cervical pulpotomy to preserve the pulp tissue vitality and achieve maturogenesis. Follow-up evaluations showed successful treatment in terms of preservation of pulp vitality and demonstrated marked continuous physiological root development. During 10 years of follow-up, both teeth were clinically asymptomatic, and radiographic evaluations showed apparent root regeneration with apical root-end closure without pulp or periapical pathosis. PMID:26622286

  17. Periodontal characteristics in individuals with varying form of the upper central incisors.

    PubMed

    Olsson, M; Lindhe, J

    1991-01-01

    It has been suggested that the variation in the morphology of the human periodontium may be related to the shape and form of the teeth. Furthermore, the severity of symptoms of periodontal disease have been proposed to differ among these various morphologic entities or "biotypes". The aim of the present study was (i) to identify individuals with markedly different crown forms and (ii) to determine probing pocket depth, probing attachment level and amount of gingival recession that had occurred at different teeth and tooth surfaces in such individuals. Clinical photographs of the maxillary incisor tooth region of 113 subjects who had been recruited for a long-term study on periodontal disease were available. The length (CL) and width (CW) of the crowns were determined and the CW/CL ratio was calculated for each tooth. 10% in each tail, 11 subjects in each group, were arbitrarily chosen as having either a long-narrow (N) or a short-wide (W) form of the central incisors. The probing pocket depth, probing attachment level and gingival recession data available from all subjects and subjects in groups W and N were compared and analyzed using the Student t-test and multiple regression analysis. The result from the analyses demonstrated that: (1) subjects with a long-narrow form of the upper central incisors had experienced more recession of the gingival margin at buccal surfaces than subjects who had a short-wide tooth form; (2) there was a significant influence of the CW/CL-ratio on the probing attachment level (p less than 0.05) and the amount of gingival recession (p less than 0.01) on buccal tooth surfaces.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2045523

  18. Management of a Two-rooted Maxillary Central Incisor Using Cone-beam Computed Tomography: Importance of Three-dimensional Imaging

    PubMed Central

    Kumar Gupta, Saurabh; Saxena, Payal; Khetarpal, Shaleen; Solanki, Mishthu

    2015-01-01

    We report a rare case of a two-rooted maxillary central incisor, stressing the importance of three-dimensional imaging in treatment planning and conservative approach of management. Endodontic treatment of this central incisor was carried out with a successful outcome. PMID:26697155

  19. Replacement of maxillary permanent central incisors lost due to trauma in the mixed-dentition.

    PubMed

    Rubel, Barry; Hill, Edward E

    2014-08-01

    Traumatic injuries to anterior teeth in children range from minor chipping to total tooth loss and occur more often in boys than in girls. The treatment of permanent tooth loss in younger patients is complicated by the difficulty of doing restorative procedures which may be influenced by pulpal size, clinical crown height, and a dental profile which is constantly changing. This case report presented a situation involving a 9-year-old boy who had experienced traumatic loss of the maxillary central incisors. Innovative materials coupled with sound principles of removable partial denture design were utilized to fabricate a cast metal removable denture prosthesis to satisfy the esthetic, functional and psychological dental needs of the patient and his parents. PMID:25265859

  20. Replacement of Maxillary Permanent Central Incisors Lost Due to Trauma in the Mixed-Dentition.

    PubMed

    Rubel, Barry; Hill, Edward E

    2015-04-01

    Traumatic injuries to anterior teeth in children range from minor chipping to total tooth loss and occur more often in boys than in girls. The treatment of permanent tooth loss in younger patients is complicated by the difficulty of doing restorative procedures which may be influenced by pulpal size, clinical crown height, and a dental profile that is constantly changing. This case report presented a situation involving a 9-year-old boy who had experienced traumatic loss of the maxillary central incisors. Innovative materials coupled with sound principles of removable partial denture design were utilized to fabricate a cast metal removable denture prosthesis to satisfy the esthetic, functional and psychological dental needs of the patient and his parents. PMID:26268010

  1. Corono-radicular biological restoration of maxillary central incisors by direct method

    PubMed Central

    Aggarwal, Sonia; Sahoo, Sujit Ranjan; Pandharkar, Kartik

    2014-01-01

    This case report refers to the esthetic and functional restorations of extensively damaged maxillary central incisors with dental caries in a 32-year-old woman, with the use of posts and crowns made from natural extracted teeth. Proper restoration of such teeth with the use of natural teeth fragments are known as biological restoration. Biological restorations can be done by using the fragments of the patients own tooth and if that is not available, tooth fragment can be obtained from an extracted tooth. These biological posts and crowns present a low cost option and an alternative technique for the morphofunctional recovery of extensively damaged teeth. There are limitations with the use of natural extracted teeth (homogenous bonding) for restoration such as the difficulty of finding teeth with a similar color and shape as that of the destroyed element, or patient may refuse to accept a tooth fragment from another patient, which prevents execution of the restoration. PMID:25540666

  2. Stress distributions in maxillary central incisors restored with various types of post materials and designs.

    PubMed

    Madfa, A A; Kadir, M R Abdul; Kashani, J; Saidin, S; Sulaiman, E; Marhazlinda, J; Rahbari, R; Abdullah, B J J; Abdullah, H; Abu Kasim, N H

    2014-07-01

    Different dental post designs and materials affect the stability of restoration of a tooth. This study aimed to analyse and compare the stability of two shapes of dental posts (parallel-sided and tapered) made of five different materials (titanium, zirconia, carbon fibre and glass fibre) by investigating their stress transfer through the finite element (FE) method. Ten three-dimensional (3D) FE models of a maxillary central incisor restored with two different designs and five different materials were constructed. An oblique loading of 100 N was applied to each 3D model. Analyses along the centre of the post, the crown-cement/core and the post-cement/dentine interfaces were computed, and the means were calculated. One-way ANOVAs followed by post hoc tests were used to evaluate the effectiveness of the post materials and designs (p=0.05). For post designs, the tapered posts introduced significantly higher stress compared with the parallel-sided post (p<0.05), especially along the centre of the post. Of the materials, the highest level of stress was found for stainless steel, followed by zirconia, titanium, glass fibre and carbon fibre posts (p<0.05). The carbon and glass fibre posts reduced the stress distribution at the middle and apical part of the posts compared with the stainless steel, zirconia and titanium posts. The opposite results were observed at the crown-cement/core interface. PMID:24834856

  3. Mineral trioxide aggregate for obturation of maxillary central incisors with necrotic pulp and open apices.

    PubMed

    Erdem, Arzu Pinar; Sepet, Elif

    2008-10-01

    There are few reports on treatment of necrotic pulps with mineral trioxide aggregate (MTA) for apexification. Five immature teeth with necrotic pulps were treated with the use of an apical plug of MTA for apexification. All teeth were central incisors that had premature interruption of root development caused by a previous trauma. According to the treatment protocol, the root canals were rinsed with 5% NaOCl; then calcium hydroxide paste was placed in the canals for 1-6 weeks. The apical portion of the canals were filled with MTA. The rest of the canals were obturated with lateral condensation of the gutta-percha applied with a canal sealer. At 6 months, 1 year and 2 year follow-up periods the clinical and radiographic appearance of the teeth showed the resolution of the periapical lesions and continued root end development in all except in the one case in which the MTA was extruded out the apex. MTA can be considered a very effective option for apexification with the advantage of reduced treatment time, good sealing ability and high biocompatibility. PMID:18557748

  4. Solitary median maxillary central incisor in association with hemifacial microsomia: A rare case report and review of literature

    PubMed Central

    Utreja, Ashok; Zahid, Syed Naved; Gupta, Richa

    2011-01-01

    Solitary median maxillary central incisor (SMMCI) is a rare dental anomaly. It is estimated to occur in 1:50,000 live births. The SMMCI tooth differs from the normal central incisor in that the crown form is symmetric and it develops and erupts precisely in the midline of the maxillary dental arch in both primary and permanent dentitions. Presence of SMMCI with hemifacial microsomia (HFM) is a very rare clinical condition. We report a case of HFM in a male of Indian origin who presented with SMMCI in both primary and permanent dentitions. The association of HFM with SMMCI may be due to defective development of neural crest cells and/or lack of space in maxilla. PMID:22346174

  5. Orthodontic Management of Pathological Migration of Central Incisor in a Patient with Moderate to Severe Periodontal Disease

    PubMed Central

    Al-Mohaimeed, Mohammad A.

    2007-01-01

    Proclination and extrusion of upper central incisors are considered as the main manifestations of pathological migration. They are the most common chief complaint of adult patients nowadays. With adequate orthodontic-periodontal teamwork it is possible to reestablish a healthy and well-functioning dentition with good occlusion, sufficient masticatory function, and satisfactory esthetics that will improve the psychological status of the patient after correcting the elongation and the migration of the anterior teeth. This report present a case with pathological migration of upper right central incisor treated orthodontically with a combination of intrusion, extrusion and retraction movement. This mechanics improve the bone topography, improve esthetics and also helps the patient to achieve good home oral hygiene care. PMID:21475457

  6. Treatment of class II malocclusion with open bite and absence of central maxillary incisor lost by trauma aided by use of orthodontic mini-implants.

    PubMed

    Pithon, Matheus Melo

    2014-02-01

    The aim of this article is to report the clinical case of non-surgical treatment of a Class II malocclusion with anterior open bite, associated with absence of a maxillary central incisor avulsed due to trauma. Treatment proceeded with the use of orthodontic mini-implants as an anchorage device for intrusion of the maxillary molars and for mesial movement of the lateral incisor to replace the central incisor. Treatment resulted in good occlusion, with anterior and lateral guides, enhancement of the facial profile, and good dental esthetic appearance without the need for prosthetic treatment. The treatment outcome was satisfactory but needs long-term or permanent retention. PMID:23331427

  7. An in vitro study of the effect endodontic access preparation has upon the retention of porcelain fused to metal crowns of maxillary central incisors.

    PubMed

    McMullen, A F; Himel, V T; Sarkar, N K

    1989-04-01

    Endodontic therapy often requires cutting access preparations through existing restorations. The purpose of this study was to determine whether endodontic access preparation affected the retention of porcelain fused to metal crowns of maxillary central incisors. Retentive forces required to displace porcelain fused to metal crowns of maxillary central incisors were measured using an Instron constant displacement rate testing machine. Using a paired t test analysis, a significant difference was found between crown retention before and after endodontic access preparation. PMID:2691625

  8. Accelerated Osteogenic Orthodontics for retreatment of a patient with diminished root length and absence of the maxillary central incisor

    PubMed Central

    Montesinos F, Armando; Linares T, Silvana; Prez-Gasque B, Marisol

    2015-01-01

    An 18-year-old female patient visited a university orthodontics department with a chief complaint of an unesthetic appearance of her teeth, including a protruded upper central incisor and unsatisfactory results from previous orthodontic treatment. Pretreatment records showed a Class II skeletal and dental relation with proclined upper and lower incisors, replacement of an absent upper left central incisor with the left upper cuspid, presence of the upper left deciduous cuspid, mild crowding, and 4mm of overbite and overjet. The panoramic radiograph showed shortened roots of multiple teeth. Accelerated Osteogenic Orthodontics (AOO) was recommended as an approach to reduce the treatment time and the risk of further root shortening. Despite being more expensive and requiring a surgical procedure, this treatment option was very attractive to the patient. The overall treatment time was 14months. Facial balance was improved, and good occlusal relationships were achieved from the functional and esthetic perspectives. In conclusion, surgically facilitated orthodontics (specifically, AOO) is an efficient and safe therapeutic tool for treating or retreating orthodontic patients with diminished root length. PMID:26644760

  9. Fracture resistance of endodontically treated maxillary central incisors with varying ferrule heights and configurations: In vitro study

    PubMed Central

    Singh, Smita; Thareja, Prerna

    2014-01-01

    Objective: The objective of this study is to determine the best ferrule configuration of endodontically treated teeth. Materials and Methods: A total of 40 freshly extracted maxillary central incisors were collected. Teeth were allocated into following four groups of each having 10 teeth. Group 1 teeth restored with crowns (CRN), Group 2 endodontically treated teeth restored with crowns (RCT and CRN), Group 3 endodontically treated teeth restored with cast dowel cores and crowns incorporating uniform 2 mm ferrule (2 FRL), Group 4 endodontically treated teeth restored with cast dowel cores and crowns incorporating uniform 1 mm ferrule (1 FRL). Crown preparation was performed with varying ferrule heights, crowns were cemented with resin modified glass ionomer cement and were kept in 100% humidity for 3 days, all specimens were loaded to failure in a universal testing machine at 0.5 mm/min. Results were obtained in the form of kilo Newton and Newton. Result: The statistical analysis applied was an analysis of variance to detect the presence of group differences. Pair wise comparisons between the groups were analyzed with the Tukey Kramer significant difference test for multiple comparisons. Conclusion: Ferrule had a significant role in the fracture resistance of custom cast post core restored teeth. Endodontically treated maxillary central incisors with a uniform 2 mm ferrule were more fracture resistant than those with a uniform 1 mm ferrule. PMID:24778504

  10. Changes in force associated with the amount of aligner activation and lingual bodily movement of the maxillary central incisor

    PubMed Central

    Li, Xiaowei; Ren, Chaochao; Wang, Zheyao; Zhao, Pai; Wang, Hongmei

    2016-01-01

    Objective The purposes of this study were to measure the orthodontic forces generated by thermoplastic aligners and investigate the possible influences of different activations for lingual bodily movements on orthodontic forces, and their attenuation. Methods Thermoplastic material of 1.0-mm in thickness was used to manufacture aligners for 0.2, 0.3, 0.4, 0.5, and 0.6 mm activations for lingual bodily movements of the maxillary central incisor. The orthodontic force in the lingual direction delivered by the thermoplastic aligners was measured using a micro-stress sensor system for the invisible orthodontic technique, and was monitored for 2 weeks. Results Orthodontic force increased with the amount of activation of the aligner in the initial measurements. The attenuation speed in the 0.6 mm group was faster than that of the other groups (p < 0.05). All aligners demonstrated rapid relaxation in the first 8 hours, which then decreased slowly and plateaued on day 4 or 5. Conclusions The amount of activation had a substantial influence on the orthodontic force imparted by the aligners. The results suggest that the activation of lingual bodily movement of the maxillary central incisor should not exceed 0.5 mm. The initial 4 or 5 days is important with respect to orthodontic treatment incorporating an aligner.

  11. A Fused Maxillary Central Incisor and Its Multidisciplinary Treatment: An 18-Year Follow-Up

    PubMed Central

    Brunet-Llobet, Llus; Lahor-Soler, Eduard; Cahuana, Abel

    2014-01-01

    Fused teeth may cause aesthetic, spacing, periodontal, eruption, and caries problems. The present case report describes a 7-year-old boy patient with a chief complaint of unerupted maxillary incisor. Radiographic examination indicated a fused tooth which had two fused roots but two independent root canals. A complex management of a fused tooth is really difficult to standardize. In this case an orthodontic, endodontic, and surgical treatment (intentional replantation) allowed the tooth to be retained until 18 years following intervention. Maintenance of the root and alveolar bone in young adults at least until full skeletal maturation should be the main treatment objective. PMID:24738034

  12. Interdisciplinary rehabilitation of a root-fractured maxillary central incisor: A 12-year follow-up case report

    PubMed Central

    Incerti Parenti, Serena; Ciocci, Maurizio; Checchi, Luigi

    2014-01-01

    Single-tooth implantation has become a common treatment solution for replacement of a root-fractured maxillary incisor in adults, but the long-term esthetic results can be unfavorable due to progressive marginal bone loss, resulting in gingival recession. In this case report, a maxillary central incisor with a root fracture in its apical one-third was orthodontically extruded and extracted in a 21-year-old female. Implant surgery was performed after a 3-month healing period, and the final crown was placed about 12 months after extraction. After 12 years, favorable osseous and gingival architectures were visible with adequate bone height and thickness at the buccal cortical plate, and no gingival recession was seen around the implant-supported crown. Although modern dentistry has been shifting toward simplified, clinical procedures and shorter treatment times, both general dentists and orthodontists should be aware of the possible long-term esthetic advantages of orthodontic extrusion of hopelessly fractured teeth for highly esthetically demanding areas and should educate and motivate patients regarding the choice of this treatment solution, if necessary. PMID:25133136

  13. Preservative management of traumatized maxillary central incisor using fiber reinforced composite and mineral trioxide aggregate: Report of a case.

    PubMed

    Surapaneni, Sai Kalyan; Chandki, Rita

    2015-08-01

    The myriads of technological advancements in dentistry in last two decades have led to a dramatic shift from conventional invasive procedures to more conservative biomimetic therapies. In this series, management of traumatic dental injuries has taken a big leap in that now it is possible to conserve many of these teeth which were otherwise doomed to extraction. Depending on the extent of injury, esthetic and functional requirements, traumatic dental injuries can be managed by a variety of clinical procedures including composite resin restorations, reattachment of fractured fragment, endodontic therapy with or without post and core or lastly extraction. Reattaching natural tooth structure offers an advantage over the others in that it is instant, provides superior esthetics, preserves the natural tooth structure and is best accepted by the patient. This paper describes the comprehensive management of traumatized maxillary central incisor involving pulp exposure while maintaining pulp vitality and natural appearance of a tooth. PMID:26604608

  14. Prosthetic rehabilitation and management of an MTA-treated maxillary central incisor with root perforation and severe internal resorption.

    PubMed

    Abuabara, Allan; Costa, Rogrio G; Morais, Eduardo C; Furuse, Adilson Y; Gonzaga, Carla C; Filho, Flares Baratto

    2013-07-01

    Root canal perforation and root resorption are challenging clinical conditions to correctly diagnose and treat, especially when they occur in anterior teeth. This clinical report describes the computed tomography findings, endodontic treatment, prosthetic rehabilitation, and clinical outcome of an iatrogenic root perforation and internal resorption in a maxillary central incisor. The case management consisted of endodontic retreatment, periodontal surgery, and prosthetic rehabilitation. Gray mineral trioxide aggregate (MTA) was used to fill the resorption space and seal the perforation. The prosthetic treatment was performed with glass fiber-reinforced dowels and all-ceramic crowns. No signs or symptoms, including discomfort, pain, or esthetic defects were observed in 30 months of follow-up. PMID:23387526

  15. Preservative management of traumatized maxillary central incisor using fiber reinforced composite and mineral trioxide aggregate: Report of a case

    PubMed Central

    Surapaneni, Sai Kalyan; Chandki, Rita

    2015-01-01

    The myriads of technological advancements in dentistry in last two decades have led to a dramatic shift from conventional invasive procedures to more conservative biomimetic therapies. In this series, management of traumatic dental injuries has taken a big leap in that now it is possible to conserve many of these teeth which were otherwise doomed to extraction. Depending on the extent of injury, esthetic and functional requirements, traumatic dental injuries can be managed by a variety of clinical procedures including composite resin restorations, reattachment of fractured fragment, endodontic therapy with or without post and core or lastly extraction. Reattaching natural tooth structure offers an advantage over the others in that it is instant, provides superior esthetics, preserves the natural tooth structure and is best accepted by the patient. This paper describes the comprehensive management of traumatized maxillary central incisor involving pulp exposure while maintaining pulp vitality and natural appearance of a tooth. PMID:26604608

  16. Solitary median maxillary central incisor and congenital nasal pyriform aperture stenosis combined with asymmetric crying facies and postaxial lower limb reduction defects: a unique combination of features.

    PubMed

    Van Dijk, F S; van Thuijl, H F; Wermeskerken, A; van Rijn, R R; Cobben, J M

    2011-01-01

    We report a boy with asymmetric crying facies and bilateral absence of the 5th ray of the feet. In addition, craniofacial computed tomography showed a solitary median maxillary central incisor in combination with a narrow apertura piriformis. To our knowledge this intriguing combination of congenital abnormalities has not been described before. PMID:21167328

  17. Approximation and contact of the maxillary central incisor roots with the incisive canal after maximum retraction with temporary anchorage devices: Report of 2 patients.

    PubMed

    Chung, Chooryung J; Choi, Yoon Jeong; Kim, Kyung-Ho

    2015-09-01

    The incisive canal is located on the median plane of the maxilla, posterior to the roots of the central incisor. Although the incisive canal is not considered an anatomic structure that may limit tooth movement, it has recently gained attention regarding the possibilities of surgical invasion and associated complications because of its proximity to the maxillary central incisors. In the 2 illustrated cases, lip protrusion was improved by en-masse bodily retraction of the anterior teeth (>8 mm) using temporary anchorage devices. Three-dimensional cone-beam computed tomography showed that the maxillary incisor roots were approximated to the incisive canal after maximum retraction. One central incisor root was in direct contact with the incisive canal with severe root resorption, but tooth vitality and the overall occlusion were stable in the long term without any sensory dysfunction. The apparent root resorption may be mainly related to the large amounts of anterior retraction and root movement in the 2 patients. However, the anatomic location of the incisive canal and the possibilities of its invasion after tooth movement should be closely monitored when maximum retraction is planned, to prevent potential complications. PMID:26321347

  18. 3D FEA of cemented glass fiber and cast posts with various dental cements in a maxillary central incisor.

    PubMed

    Madfa, Ahmed A; Al-Hamzi, Mohsen A; Al-Sanabani, Fadhel A; Al-Qudaimi, Nasr H; Yue, Xiao-Guang

    2015-01-01

    This study aimed to analyse and compare the stability of two dental posts cemented with four different luting agents by examining their shear stress transfer through the FEM. Eight three-dimensional finite element models of a maxillary central incisor restored with glass fiber and Ni-Cr alloy cast dental posts. Each dental post was luted with zinc phosphate, Panavia resin, super bond C&B resin and glass ionomer materials. Finite element models were constructed and oblique loading of 100 N was applied. The distribution of shear stress was investigated at posts and cement/dentine interfaces using ABAQUS/CAE software. The peak shear stress for glass fiber post models minimized approximately three to four times of those for Ni-Cr alloy cast post models. There was negligible difference in peak of shear stress when various cements were compared, irrespective of post materials. The shear stress had same trend for all cement materials. This study found that the glass fiber dental post reduced the shear stress concentration at interfacial of post and cement/dentine compared to Ni-Cr alloy cast dental post. PMID:26543733

  19. An In Vitro Study on the Effects of Post-Core Design and Ferrule on the Fracture Resistance of Endodontically Treated Maxillary Central Incisors

    PubMed Central

    Sreedevi, S; Sanjeev, R; Raghavan, Rekha; Abraham, Anna; Rajamani, T; Govind, Girish Kumar

    2015-01-01

    Background: Endodontically treated teeth have significantly different physical and mechanical properties compared to vital teeth and are more prone to fracture. The study aims to compare the fracture resistance of endodontically treated teeth with and without post reinforcement, custom cast post-core and prefabricated post with glass ionomer core and to evaluate the ferrule effect on endodontically treated teeth restored with custom cast post-core. Materials and Methods: A total of 40 human maxillary central incisors with similar dimensions devoid of any root caries, restorations, previous endodontic treatment or cracks were selected from a collection of stored extracted teeth. An initial silicone index of each tooth was made. They were treated endodontically and divided into four groups of ten specimens each. Their apical seal was maintained with 4 mm of gutta-percha. Root canal preparation was done and then post core fabrication was done. The prepared specimens were subjected to load testing using a computer coordinated UTM. The fracture load results were then statistically analyzed. One-way ANOVA was followed by paired t-test. Results: 1. Reinforcement of endodontically treated maxillary central incisors with post and core, improved their fracture resistance to be at par with that of endodontically treated maxillary central incisor, with natural crown. 2. The fracture resistance of endodontically treated maxillary central incisors is significantly increased when restored with custom cast post-core and 2 mm ferrule. Conclusion: With 2 mm ferrule, teeth restored with custom cast post-core had a significantly higher fracture resistance than teeth restored with custom cast post-core or prefabricated post and glass ionomer core without ferrule. PMID:26464537

  20. Amalgamation of allogenic bone graft, platelet-rich fibrin gel, and PRF membrane in auto-transplantation of an impacted central incisor.

    PubMed

    Chaudhary, Zainab; Kumar, Yuvika Raj; Mohanty, Sujata; Khetrapal, Ambica

    2015-01-01

    "Social six" teeth refers to the maxillary incisors and canines that play a vital role in the appearance of an individual and absence of any one of them has a significant psycho-social impact. Hence, early treatment and rehabilitation of the same are extremely important. A multitude of treatment options ranging from orthodontic extrusion, extraction followed by implant placement, fixed partial denture, and auto-transplantation have been advocated. This case report discusses the unique amalgamation of platelet-rich fibrin (PRF), demineralized freeze-dried bone graft with use of PRF membrane during auto-transplantation of an impacted central incisor. The authors have focused on maximum usage of autogenous materials in the most economic and least invasive manner. Furthermore, this amalgamation has been used to provide rehabilitation in the least span of time. PMID:26097366

  1. Amalgamation of allogenic bone graft, platelet-rich fibrin gel, and PRF membrane in auto-transplantation of an impacted central incisor

    PubMed Central

    Chaudhary, Zainab; Kumar, Yuvika Raj; Mohanty, Sujata; Khetrapal, Ambica

    2015-01-01

    Social six teeth refers to the maxillary incisors and canines that play a vital role in the appearance of an individual and absence of any one of them has a significant psycho-social impact. Hence, early treatment and rehabilitation of the same are extremely important. A multitude of treatment options ranging from orthodontic extrusion, extraction followed by implant placement, fixed partial denture, and auto-transplantation have been advocated. This case report discusses the unique amalgamation of platelet-rich fibrin (PRF), demineralized freeze-dried bone graft with use of PRF membrane during auto-transplantation of an impacted central incisor. The authors have focused on maximum usage of autogenous materials in the most economic and least invasive manner. Furthermore, this amalgamation has been used to provide rehabilitation in the least span of time. PMID:26097366

  2. Neonatal line width in deciduous incisors from Neolithic, mediaeval and modern skeletal samples from north-central Poland.

    PubMed

    Kurek, Marta; Żądzińska, Elżbieta; Sitek, Aneta; Borowska-Strugińska, Beata; Rosset, Iwona; Lorkiewicz, Wiesław

    2016-01-01

    The neonatal line is usually the first accentuated incremental line visible on the enamel. The prenatal environment significantly contributes to the width of the neonatal line, influencing the pace of reaching post-delivery homeostasis by the newborn's organism. Studies of the enamel of the earliest developing deciduous teeth can provide an insight into the prenatal development and the perinatal conditions of children of past human populations, thus being an additional source contributing to consideration of the influence of prenatal and perinatal factors modifying growth processes. The aim of this study was to examine whether the neonatal line, reflecting the conditions of the prenatal and perinatal environment, differed between the Neolithic, the mediaeval and the modern populations from the Kujawy region in north-central Poland. The material consisted of longitudinally ground sections of 57 human deciduous incisors obtained from children aged 1.0-7.5 years representing three archaeological series from Brześć Kujawski site. All teeth were sectioned in the labio-linqual plane using a diamond blade (Buechler IsoMet 1000). Final specimens were observed with the microscope Delta Optical Evolution 300 at 10× and 40× magnifications. For each tooth, linear measurements of the neonatal line width were performed on its labial surface at the three levels from the cemento-enamel junction. No significant difference was found in the mean neonatal line width depending on the tooth type and archaeological site, although the thickest neonatal line characterised children from the Neolithic series. In all analysed series, the neonatal line width was diversified depending on the child's age at death. The value of Spearman's rank correlation coefficient calculated for the correlation between the child's age at death and the neonatal line width was statistically significant. A clear increase in the width of the neonatal line was thus observed along with a decrease in the child's age at death. PMID:25800876

  3. Clinical course and implications of congenital nasal pyriform stenosis and solitary median maxillary central incisor in a newborn: a case report

    PubMed Central

    2014-01-01

    Introduction Congenital nasal pyriform aperture stenosis and solitary median maxillary central incisor are uncommon anomalies and are associated with further malformations. Solitary median maxillary central incisor itself has initially no impact on a childs health, but congenital nasal pyriform aperture stenosis is a potentially life-threatening condition. Case presentation A Caucasian baby boy showed severe dyspnoea and was intubated orotracheally. Multiple anomalies were detected, including urogenital and craniofacial malformations. Computed tomography scans revealed congenital nasal pyriform aperture stenosis with a diameter of 4.9mm and a solitary median maxillary central incisor. A 3.0mm tube was inserted in his left nasal cavity, and the baby was able to breathe sufficiently and spontaneously. The nasal tube was removed after seven days, and the baby was discharged under application of decongestant drops. After seven months, the baby was readmitted with respiratory distress, and surgery was carried out using an intraoral sublabial approach. The stenotic area of the pyriform aperture was widened, and 3.0mm tubes were inserted in both nasal cavities for 10 days. Over a period of six months, no further respiratory distress has occurred. Conclusions The decision to perform surgery was delayed since the babys nasal breathing was adequate as a result of the insertion of a nasal tube. Since treatment depends on the severity of symptoms, it is appropriate in some cases to take a conservative approach at first, and to keep surgery as a last resort. Once a conservative approach has been selected for congenital nasal pyriform aperture stenosis, awareness of the life-threatening nature of the condition should be kept in mind, and a surgical approach must still be taken into account. PMID:24950703

  4. Evaluation of the Load-bearing Capacity of Fractured Incisal Edge of Maxillary Permanent Central Incisors restored with a Glass Fiber-reinforced Nanocomposite: An in vitro Study

    PubMed Central

    Srilatha, KT; Nandlal, B; Dhull, Kanika Singh

    2015-01-01

    ABSTRACT Objectives: The aim of this study was to evaluate and compare the load-bearing capacity of fractured incisal edge of maxillary permanent central incisors restored with a nanocomposite and a glass fiber-reinforced nanocomposite. Materials and methods: Thirty-six extracted sound maxillary central incisors randomly divided in three groups were used for the present study. Group I (control) contained untreated teeth. Samples in experimental groups II and III were prepared by cutting the incisal (one-third) part of the crown horizontally and subjected to enamel preparations and restored with a nanocomposite and a glass fiber-reinforced nanocomposite respectively. All restored teeth were stored in distilled water at room temperature for 24 hours. Fracture resistance was evaluated as peak load at failure (Newton) for samples tested in a cantilever-bending test using Hounsfield universal testing machine. Failure modes were microscopically examined. Results: Highest mean peak failure load (Newton) among experimental groups was observed in glass fiber-reinforced nano composite group (863.50 ± 76.12 N) followed by nanocomposite group (633.67 ± 40.14 N). One-way analysis of variance (ANOVA) revealed that the restoration technique significantly affected the load-bearing capacity (p < 0.001). Scheffe’s post-hoc comparison test (subset for α = 0.05) revealed that there was significant difference in the mean peak failure load values of nanocomposite and glass fiber-reinforced nanocomposite groups when considered together (p < 0.001). Experimental groups showed similar types of failure modes with majority occurring ascohesive and mixed type. Fifty-eight percent of the teeth in glass fiber-reinforced nanocomposite group fractured below the cementoenamel junction. Conclusion: By using fiber-reinforced composite substructure under conventional composites in the repair of fractured incisors, the load-bearing capacity of the restored incisal edge could be substantially increased. How to cite this article: Kumar PSP, Srilatha KT, Nandlal B, Dhull KS. Evaluation of the Load-bearing Capacity of Fractured Incisal Edge of Maxillary Permanent Central Incisors restored with a Glass Fiber-reinforced Nanocomposite: An in vitro Study. Int J Clin Pediatr Dent 2015;8(1):22-29. PMID:26124577

  5. Use of Cone-beam Computed Tomography during Retreatment of a 2-rooted Maxillary Central Incisor: Case Report of a Complex Diagnosis and Treatment.

    PubMed

    Levin, Avi; Shemesh, Avi; Katzenell, Vered; Gottlieb, Ayelet; Ben Itzhak, Joe; Solomonov, Michael

    2015-12-01

    A double-rooted maxillary incisor is an extremely rare anatomic variation. Only a few case reports describe this abnormal anatomy. In recent decades, cone-beam computed tomographic (CBCT) imaging has become more common for endodontic purposes. This case report describes the retreatment of double-rooted maxillary central incisors using CBCT imaging. In 2012, a 20-year-old man was referred to our department because of asymptomatic periapical lesions in teeth #8, #9, and #10. During the evaluation of a periapical radiograph, a rare anatomic variation, in the form of an additional root of tooth #9, was detected, and it was impossible to decide about the source of the lesion between teeth #9 and #10. During retreatment, after gutta-percha removal, CBCT imaging was performed; this allowed proper treatment of the additional root and a final diagnosis of normal periapical tissue of tooth #10 with no treatment needed. The 18-month follow-up revealed a healing lesion in tooth #9 and normal periapical tissue in tooth #10. During the treatment of teeth with an anatomic variation, CBCT imaging can serve as an auxiliary tool for 3-dimensional evaluation that influences treatment steps and techniques. CBCT scanning can be very useful in assessing the actual location of a periapical lesion, which influences diagnosis and treatment planning. PMID:26478437

  6. Reconstruction and Intentional Replantation of a Maxillary Central Incisor with a Complete Vertical Root Fracture: A Rare Case Report with Three Years Follow up.

    PubMed

    Dua, Deepti; Dua, Ankur

    2015-09-01

    Vertical root fractures in teeth present with challenges not only with diagnosis but also with management. The prognosis in such teeth is generally questionable with extraction of the tooth being the most common treatment option. However, conservative treatment options such as reconstruction of the fractured fragments with adhesive resin followed by intentional replantation have been recently suggested. There are only a few case reports that describe management of complete vertical root fracture by reconstruction of fragments. The present case report describes successful management of an unusual complete vertical root fracture of a maxillary right central incisor in a 23-year-old male by reconstructing the fragments with a dual cure resin followed by intentional replantation. At the three year follow up, the tooth was asymptomatic, radiographically sound with probing depth and mobility within normal physiological limits. PMID:26501026

  7. Reconstruction and Intentional Replantation of a Maxillary Central Incisor with a Complete Vertical Root Fracture: A Rare Case Report with Three Years Follow up

    PubMed Central

    Dua, Deepti

    2015-01-01

    Vertical root fractures in teeth present with challenges not only with diagnosis but also with management. The prognosis in such teeth is generally questionable with extraction of the tooth being the most common treatment option. However, conservative treatment options such as reconstruction of the fractured fragments with adhesive resin followed by intentional replantation have been recently suggested. There are only a few case reports that describe management of complete vertical root fracture by reconstruction of fragments. The present case report describes successful management of an unusual complete vertical root fracture of a maxillary right central incisor in a 23-year-old male by reconstructing the fragments with a dual cure resin followed by intentional replantation. At the three year follow up, the tooth was asymptomatic, radiographically sound with probing depth and mobility within normal physiological limits. PMID:26501026

  8. Endodontic and Esthetic Management of a Dilacerated Maxillary Central Incisor Having Two Root Canals Using Cone Beam Computed Tomography as a Diagnostic Aid

    PubMed Central

    Sharma, Sarang; Grover, Shibani; Sharma, Vivek; Srivastava, Dhirendra; Mittal, Meenu

    2014-01-01

    Traumatic injuries to the primary dentition are quite common. When primary teeth are subjected to trauma, force transmission and/or invasion of the underlying tooth germs lying in close proximity can result in a variety of disturbances in the permanent successors. Few of these disturbances include hypoplasia, dilaceration, or alteration in the eruption sequence and pattern. Dilaceration is defined as an angulation or sharp bend or curve in the linear relationship of the crown of a tooth to its root. A rare case of maxillary left central incisor having crown dilaceration and Vertucci's type II canal configuration with symptomatic periapical periodontitis is reported. Cone beam computed tomography was used for better understanding of the anomaly and complicated root canal morphology. The tooth was successfully managed by nonsurgical root canal therapy and restoration with resin composite to restore esthetics. PMID:24955260

  9. Relationship of central incisor implant placement to the ridge configuration anterior to the nasopalatine canal in dentate and partially edentulous individuals: a comparative study.

    PubMed

    Jia, Xueting; Hu, Wenjie; Meng, Huanxin

    2015-01-01

    Background. The aims of this study were to investigate the ridge contour anterior to the nasopalatine canal, and the difference between the incidences of the nasopalatine canal perforation in dentate and partially edentulous patients by cone-beam computed tomography. Methods. Cone-beam computed tomography scan images from 72 patients were selected from database and divided into dentate and partially edentulous groups. The configuration of the ridge anterior to the canal including palatal concavity depth, palatal concavity height, palatal concavity angle, bone height coronal to the incisive foramen, and bone width anterior to the canal was measured. A virtual implant placement procedure was used, and the incidences of perforation were evaluated after implant placement in the cingulum position with the long axis along with the designed crown. Results. Comparing with variable values from dentate patients, the palatal concavity depth and angle were greater by 0.9 mm and 4°, and bone height was shorter by 1.1 mm in partially edentulous patients, respectively. Bone width in edentulous patients was narrower than in dentate patients by 1.2 mm at incisive foramen level and 0.9 mm at 8 mm subcrestal level, respectively. After 72 virtual cylindrical implants (4.1 × 12 mm) were placed, a total of 12 sites (16.7%) showed a perforation and three-fourths occurred in partially edentulous patients. After replacing with 72 tapered implants (4.3 × 13 mm), only 6 implants (8.3%) broke into the canal in the partially edentulous patient group. Conclusions. The nasopalatine canal may get close to the implant site and the bone width anterior to the canal decreases after the central incisor extraction. The incidence of nasopalatine canal perforation may occur more commonly during delayed implant placement in central incisor missing patients. PMID:26557434

  10. Relationship of central incisor implant placement to the ridge configuration anterior to the nasopalatine canal in dentate and partially edentulous individuals: a comparative study

    PubMed Central

    2015-01-01

    Background. The aims of this study were to investigate the ridge contour anterior to the nasopalatine canal, and the difference between the incidences of the nasopalatine canal perforation in dentate and partially edentulous patients by cone-beam computed tomography. Methods. Cone-beam computed tomography scan images from 72 patients were selected from database and divided into dentate and partially edentulous groups. The configuration of the ridge anterior to the canal including palatal concavity depth, palatal concavity height, palatal concavity angle, bone height coronal to the incisive foramen, and bone width anterior to the canal was measured. A virtual implant placement procedure was used, and the incidences of perforation were evaluated after implant placement in the cingulum position with the long axis along with the designed crown. Results. Comparing with variable values from dentate patients, the palatal concavity depth and angle were greater by 0.9 mm and 4°, and bone height was shorter by 1.1 mm in partially edentulous patients, respectively. Bone width in edentulous patients was narrower than in dentate patients by 1.2 mm at incisive foramen level and 0.9 mm at 8 mm subcrestal level, respectively. After 72 virtual cylindrical implants (4.1 × 12 mm) were placed, a total of 12 sites (16.7%) showed a perforation and three-fourths occurred in partially edentulous patients. After replacing with 72 tapered implants (4.3 × 13 mm), only 6 implants (8.3%) broke into the canal in the partially edentulous patient group. Conclusions. The nasopalatine canal may get close to the implant site and the bone width anterior to the canal decreases after the central incisor extraction. The incidence of nasopalatine canal perforation may occur more commonly during delayed implant placement in central incisor missing patients. PMID:26557434

  11. The chronological distribution of enamel hypoplasia in human permanent incisor and canine teeth.

    PubMed

    Goodman, A H; Armelagos, G J

    1985-01-01

    The frequencies and chronology, based on a standard tooth development chart, of enamel hypoplasia derived from permanent upper central incisors and mandibular canines were compared for 42 prehistoric Amerindians. Between 0.5 and 4.5 years, when the crowns of both these teeth are developing, hypoplasias were 1.36 times more common on the incisors (54 hypoplasias/incisor; 40 hypoplasias/canine). Hypoplasias on incisors occurred earlier (mean = 2.50; median at 2.0-2.5 years) compared to the canine (mean = 3.51; median at 3.5-4.0 years). Differences in published frequencies and chronologies of hypoplasias may be explained, in part, by an indefinable variation in the teeth studied. The highest density of hypoplasias on both tooth crowns was just cervical to the midpoint, suggesting that developmental rates and crown geometry may influence the ability of the crown to record stressful events. PMID:3901982

  12. Effects of post materials and length on the stress distribution of endodontically treated maxillary central incisors: a 3D finite element analysis.

    PubMed

    Hsu, M-L; Chen, C-S; Chen, B-J; Huang, H-H; Chang, C-L

    2009-11-01

    Traditionally, using a long post can cause progressive removal of the root structure, complicate the ability to re-treat the tooth if necessary and make it difficult to apply an adhesive bonding agent into the root canal. It is unclear if a shorter post length can be applied when a light translucent glass fibre post and adhesive resin cement are used. The aim of this study was to evaluate the biomechanical performance of endodontically treated teeth restored with three post materials, glass-fibre, stainless steel and cast-nickel chromium posts and cores of different lengths of 7, 10 and 13 mm. A 3D finite element analysis model of the maxillary central incisor was constructed. An occlusal load of 300 N was applied to a node at the palatal surface of the crown at 45 degrees to the long axis of the tooth. von Mises stress analyses were carried out in three regions. Simulated data were collected for plotting various pattern graphics and conducting statistical tests. The pattern graphics showed that when the post length changed from 13 to 7 mm, the stress patterns were even and flat in all fibre-post groups, while the stress patterns of the metal-post groups showed an M-shaped peak and trough. Statistical tests showed that the shorter fibre post was superior to the longer metal post in some situations. Within the limitations of this study, it was concluded that when a metal post is used, the post should be as long as possible, while the biomechanical performance of a glass-fibre post combined with a composite resin core was less sensitive to post length. PMID:19840225

  13. Surgical endodontic management of infected lateral canals of maxillary incisors

    PubMed Central

    2015-01-01

    This case report presents surgical endodontic management outcomes of maxillary incisors that were infected via the lateral canals. Two cases are presented in which endodontically-treated maxillary central incisors had sustained lateral canal infections. A surgical endodontic treatment was performed on both teeth. Flap elevation revealed vertical bone destruction along the root surface and infected lateral canals, and microscopy revealed that the lateral canals were the origin of the lesions. After the infected lateral canals were surgically managed, both teeth were asymptomatic and labial fistulas were resolved. There were no clinical or radiographic signs of surgical endodontic management failure at follow-up visits. This case report highlights the clinical significance and surgical endodontic management of infected lateral canal of maxillary incisor. It is important to be aware of root canal anatomy variability in maxillary incisors. Maxillary central incisors infected via the lateral canal can be successfully managed by surgical endodontic treatment. PMID:25671217

  14. Multi-disciplinary management of a patient with a post-traumatised incisor presenting concurrent replacement and inflammatory resorption: a case report.

    PubMed

    Doğramaci, Esma J; Rossi-Fedele, Giampiero; Jonest, Allan G

    2015-11-01

    This case report describes the multidisciplinary management of a young male who presented with a Class I incisor relationship and bi-maxillary dento-alveolar protrusion on a Class I skeletal base. The occlusion was complicated by an ankylosed and moderately infra-positioned upper left permanent central incisor, an anterior crossbite, crowding, a reduced overbite and centreline discrepancy. The incisor was traumatised and avulsed when the root was immature and the tooth was reimplanted with delay. On referral for orthodontic treatment at age 11 .5 years, the upper left central incisor was experiencing ankylosis-related (osseous replacement) resorption and external root resorption simultaneously. Aside from the orthodontic aims, it was important to address the disrupted alveolar development to facilitate later prosthodontic replacement of the upper left permanent central incisor by idealising the inter-coronal and inter-radicular spaces. Treatment consisted of fixed orthodontic appliances in conjunction with the extraction of all second premolars and the upper left permanent central incisor with episodic surgical curettage. An upper Hawlix retainer was provided immediately at debond and a cantilevered resin-retained bridge was placed four months later. PMID:26999896

  15. Molar Incisor Hypomineralization, Prevalence, and Etiology

    PubMed Central

    Allazzam, Sulaiman Mohammed; Alaki, Sumer Madani; El Meligy, Omar Abdel Sadek

    2014-01-01

    Aim. To evaluate the prevalence and possible etiological factors associated with molar incisor hypomineralization (MIH) among a group of children in Jeddah, Saudi Arabia. Methods. A group of 8-12-year-old children were recruited (n = 267) from the Pediatric Dental Clinics at the Faculty of Dentistry, King Abdulaziz University. Children had at least one first permanent molar (FPM), erupted or partially erupted. Demographic information, children's medical history, and pregnancy-related data were obtained. The crowns of the FPM and permanent incisors were examined for demarcated opacities, posteruptive breakdown (PEB), atypical restorations, and extracted FPMs. Children were considered to have MIH if one or more FPM with or without involvement of incisors met the diagnostic criteria. Results. MIH showed a prevalence of 8.6%. Demarcated opacities were the most common form. Maxillary central incisors were more affected than mandibular (P = 0.01). The condition was more prevalent in children with history of illnesses during the first four years of life including tonsillitis (P = 0.001), adenoiditis (P = 0.001), asthma (P = 0.001), fever (P = 0.014), and antibiotics intake (P = 0.001). Conclusions. The prevalence of MIH is significantly associated with childhood illnesses during the first four years of life including asthma, adenoid infections, tonsillitis, fever, and antibiotics intake. PMID:24949012

  16. MAPK mediates Hsp25 signaling in incisor development.

    PubMed

    Lee, Min-Jung; Cai, Jinglei; Kwak, Sung-Wook; Cho, Sung-Won; Harada, Hidemitsu; Jung, Han-Sung

    2009-05-01

    Rodent incisors are continuously growing teeth that include all stages of amelogenesis. Understanding amelogenesis requires investigations of the genes and their gene products control the ameloblast phenotype. One of the mechanisms related to tooth differentiation is mitogen-activated protein kinase (MAPK) signaling. The extracellular-signal regulated kinase (ERK)/mitogen-activated protein kinase kinase (MEK) cascade is associated with mechanisms that control the cell cycle and cell survival. However, the roles of cascades in incisor development remain to be determined. In this study, we investigated incisor development and growth in the mouse based on MAPK signaling. Moreover, heat-shock protein (Hsp)-25 is well known to be a useful marker of odontoblast differentiation. We used anisomycin (a protein-synthesis inhibitor that activates MAPKs) and U0126 (a MAPK inhibitor that blocks ERK1/2 phosphorylation) to examine the role of MAPKs in Hsp25 signaling in the development of the mouse incisor. We performed immunohistochemistry and in vitro culture using incisor tooth germ, and found that phospho-ERK (pERK), pMEK, and Hsp25 localized in developing incisor ameloblasts and anisomycin failed to produce incisor development. In addition, Western blotting results showed that anisomycin stimulated the phosphorylation of ERK, MEK, and Hsp25, and that some of these proteins were blocked by the U0126. These findings suggest that MAPK signals play important roles in incisor formation, differentiation, and development by mediating Hsp25 signaling. PMID:19225803

  17. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report.

    PubMed

    Forghani, Maryam; Parisay, Iman; Maghsoudlou, Amir

    2013-08-01

    Traumatic injuries to an immature permanent tooth may result in cessation of dentin deposition and root maturation. Endodontic treatment is often complicated in premature tooth with an uncertain prognosis. This article describes successful treatment of two traumatized maxillary central incisors with complicated crown fracture three months after trauma. The radiographic examination showed immature roots in maxillary central incisors of a 9-year-old boy with a radiolucent lesion adjacent to the right central incisor. Apexogenesis was performed for the left central incisor and revascularization treatment was considered for the right one. In 18-month clinical and radiographic follow-up both teeth were asymptomatic, roots continued to develop, and periapical radiolucency of the right central incisor healed. Considering the root development of these contralateral teeth it can be concluded that revascularization is an appropriate treatment method in immature necrotic teeth. PMID:24010086

  18. Apexogenesis and revascularization treatment procedures for two traumatized immature permanent maxillary incisors: a case report

    PubMed Central

    Forghani, Maryam; Maghsoudlou, Amir

    2013-01-01

    Traumatic injuries to an immature permanent tooth may result in cessation of dentin deposition and root maturation. Endodontic treatment is often complicated in premature tooth with an uncertain prognosis. This article describes successful treatment of two traumatized maxillary central incisors with complicated crown fracture three months after trauma. The radiographic examination showed immature roots in maxillary central incisors of a 9-year-old boy with a radiolucent lesion adjacent to the right central incisor. Apexogenesis was performed for the left central incisor and revascularization treatment was considered for the right one. In 18-month clinical and radiographic follow-up both teeth were asymptomatic, roots continued to develop, and periapical radiolucency of the right central incisor healed. Considering the root development of these contralateral teeth it can be concluded that revascularization is an appropriate treatment method in immature necrotic teeth. PMID:24010086

  19. Lower incisor position in differentmalocclusionsandfacial patterns

    PubMed Central

    Hernndez-Sayago, Estrella; Barrera-Mora, Jose M.; Ruiz-Navarro, Maria B.; Llamas-Carreras, Jose M.; Solano-Reina, Enrique

    2013-01-01

    Introduction: The position of lower incisor has been of considerable concern when planning an orthodontic treatment, having been recognized as one of diagnostic keys, Very important in the development of malocclusion and facial pattern. Objectives: In this study we claim to determine the importance of the position and inclination of lower incisor in the different malocclusions and facial patterns, and to base which of the cephalometric measurement parameters are the mostreliable. Material and Methods: Ninety lateral radiographies were taken, and they were classified by skeletal malocclusion and facial pattern.These teleradiographies have been performed cephalometric analysis, which includelower incisor position belong the following analysis: Ricketts, Riolo, Tweed, McHorris, Jarabak-MSE and Holdaway. Study Design: Cross-sectional study where we perform statistical analysis Anova test, Pearson correlations and Bonferroni analysis. Results: The analyzed measurements present a statistically significant differentiation in lower incisor inclination respect to the anterior cranial base, McHorris angle, angulation of lower incisor respect to occlusal plane and mandibular plane. Conclusions: There are statistically significant differentiation in lower incisor position and inclination respect the malocclusion and individual facial pattern. Key words:Lower incisor, cephalometric analysis, facial patterns, facial biotype, skeletal malocclusions. PMID:23229262

  20. Effect of coffe and a cola-based soft drink on the color stability of bleached bovine incisors considering the time elapsed after bleaching

    PubMed Central

    PIROLO, Rodrigo; MONDELLI, Rafael Francisco Lia; CORRER, Gisele Maria; GONZAGA, Carla Castiglia; FURUSE, Adilson Yoshio

    2014-01-01

    There is no consensus about the waiting time necessary for the patient to start consuming beverages containing colorants again after bleaching. Objective: To evaluate the influence of beverages with coloring agents on bleached bovine incisors considering the time elapsed after bleaching. Materials and methods: Sixty bovine incisors were bleached with 35% hydrogen peroxide for in-office use (Whiteness HP Max) and divided into 10 groups. The color was evaluated with a spectrophotometer (Spectro Shade MICRO) before and after bleaching, employing the CIE-Lab system. After bleaching, the teeth were exposed for 5 min to coffee or cola-based soft drink (CBSD) at different periods after bleaching: 10 min, 1 h, 24 h, 48 h, and 72 h. Color (∆E) and lightness (∆L) variations were obtained from the CIE-Lab coordinates. Data were subjected to two-way ANOVA and Tukey HSD tests (p<0.05). Results: Significant differences were observed between groups for both the ∆L and ∆E values (p<0.001). All specimens presented a decrease in brightness (negative ∆L). The highest ∆E values were observed for teeth stained with a CBSD at 10 min and 1 h (4.12 and 4.16, respectively). Teeth pigmented with coffee presented ∆E values below 3.3 units for all evaluation times. Conclusion: The exposure to coffee after bleaching causes less color changes than the exposure to a CBSD regardless of the time after bleaching. PMID:25075672

  1. Social judgments made by children (1015 year old) in relation to visible incisors trauma: School-based cross-sectional study in Khartoum state, Sudan

    PubMed Central

    Awooda, Elhadi Mohieldin; Ali, Yasmeen Abdul-Hai

    2015-01-01

    Background: Dento-alveolar trauma is a very common occurrence in childhood; however, there is a paucity of data about children's judgments in relation to dental status. There is a significant correlation between the children's incisor teeth status and the social judgments made by their peers. Aim: The purpose of this study was to determine whether the social attributes of a school child would be influenced by his or her incisor teeth status. Also, it is aimed to determine the judgment between male and female children and different age groups within the same class. Setting and Design: A descriptive cross-sectional study conducted among 178 male and female children from year 5 (age 1011 years) of primary school and year 2 of secondary school (age 1415 years) within Khartoum state. Materials and Methods: Students were invited to look at colored photographs of four different children's faces and to make a social judgment about these children's photographs. Using a previously validated child-centered questionnaire, participants rated subjects using a four-point Likert scale for three negative and six positive attributes. Statistical Analysis: Total attribute scores were tested for significant differences, according to whether the subject had visible incisor trauma or not, using t-test and analysis of variance (ANOVA) test with the level of significance set at P ? 0.05. Results: Children with visible incisor trauma were given more negative attributes than children without incisor trauma (P = 0.05). Results were similar in both genders and both school years. Younger students within the same class gave more negative attributes toward children with visible incisor trauma than their older peers, with P = 0.04 and P = 0.9 for children aged 10 years and 11 years, respectively. Conclusion: The data confirmed results of previous studies that children with visible incisor trauma are seen more negatively than those without visible incisor trauma. PMID:26539397

  2. Pulp revascularization after repositioning of impacted incisor with a dilacerated root and a detached apex.

    PubMed

    Plakwicz, Paweł; Kapuścińska, Agnieszka; Kukuła, Krzysztof; Czochrowska, Ewa Monika

    2015-06-01

    Severely impacted and dilacerated incisors are rarely considered for surgical exposure because they may not respond favorably to orthodontic extrusion. These incisors are often extracted, resulting in the need for tooth replacement; however, prosthetic solutions are limited in growing patients. Transalveolar autotransplantation of an impacted incisor may be the only method to preserve the natural tooth and maintain the shape of the alveolus. The severely impacted upper central incisor (#9) with a developing root was diagnosed in a 9-year-old girl. The unfavorable tooth position and dilaceration of its root made orthodontic extrusion of the impacted incisor impossible. Initial orthodontic space opening at the recipient site was performed before the surgery. Transalveolar transplantation of the impacted incisor to its normal position was performed to avoid tooth extraction. The incisor was later aligned using fixed orthodontic appliances. At the 5-year follow-up, the transplanted incisor presented features that were typical of a revascularized tooth (ie, obliteration of root canal but a positive response to vitality tests). Healthy periodontal tissues and continued root development were also noted. However, the root apex, which separated from the transplant at the time of the surgery, continued formation in its initial position. Transalveolar transplantation of an unfavorably impacted upper central incisor with a dilacerated root is a successful treatment, which stands the test of time. The early stage of root development allowed revascularization of the tooth despite dilaceration of the root and detachment of its apex. PMID:25770037

  3. Orthodontic retraction of autotransplanted premolar to replace ankylosed maxillary incisor with replacement resorption.

    PubMed

    Choi, Yoon Jeong; Shin, Sujung; Kim, Kyung-Ho; Chung, Chooryung J

    2014-04-01

    This case report describes the successful treatment of an adult with lip protrusion and a previously traumatized maxillary central incisor that had experienced replacement root resorption. An extracted premolar was transplanted into the incisor space and retracted orthodontically. Autotransplantation was successful with complete root formation and, combined with orthodontic treatment, provided a satisfying esthetic outcome. PMID:24703290

  4. Improving orthodontic results in cases with maxillary incisors missing.

    PubMed

    Zachrisson, B U

    1978-03-01

    This article has aimed at providing information on how to improve clinical orthodontic results in cases in which maxillary central and lateral incisors are missing. Different sections deal with (1) treatment approach and mechanics, (2) details in finishing, (3) modifications of clinical tooth crowns by special procedures (grinding, composite "corners," gingivectomy), (4) functional considerations and root resorption, and (5) retention. PMID:274073

  5. Two-dimensional photoelastic stress analysis of traumatized incisor.

    PubMed

    Topbasi, B; Gunday, M; Bas, M; Turkmen, C

    2001-01-01

    In this study, stress of traumatized incisor and the effect of stress on tooth and alveolar bone was studied with two-dimensional photoelasticity. Two homogeneous two-dimensional maxillary central incisor models were prepared. Loads were applied to the labial side of incisal edge and middle third of the crown at angles of 45 degrees and 90 degrees. It was observed that stress was increased on teeth and alveolar bone when load was applied 90 degrees on labial side of incisal edge. PMID:11445918

  6. Evaluating Stress Distribution Pattern in Periodontal Ligament of Maxillary Incisors during Intrusion Assessed by the Finite Element Method

    PubMed Central

    Salehi, Parisa; Gerami, Alayar; Najafi, Amirhosein; Torkan, Sepideh

    2015-01-01

    Statement of the Problem The use of miniscrews has expedited the true maxillary incisor intrusion and has minimized untoward side effects such as labial tipping. Purpose The aim of this study was to assess the stress distribution in the periodontal ligament of maxillary incisors when addressed to different models of intrusion mechanics using miniscrews by employing finite element methods. The degree of relative and absolute intrusion of maxillary incisors in different conditions was also evaluated. Materials and Method Finite element model of maxillary central incisor to first premolar was generated by assembling images obtained from a three-dimensional model of maxillary dentition. Four different conditions of intrusion mechanics were simulated with different placement sites of miniscrews as well as different points of force application. In each model, 25-g force was applied to maxillary incisors via miniscrews. Results In all four models, increased stress values were identified in the apical region of lateral incisor. Proclination of maxillary incisors was also reported in all the four models. The minimum absolute intrusion was observed when the miniscrew was placed between the lateral incisor and canine and the force was applied at right angles to the archwire, which is very common in clinical practice. Conclusion From the results yield by this study, it seems that the apical region of lateral incisor is the most susceptible region to root resorption during anterior intrusion. When the minimum flaring of maxillary incisors is required in clinical situations, it is suggested to place the miniscrew halfway between the roots of lateral incisor and canine with the force applied to the archwire between central and lateral incisor. In order to achieve maximum absolute intrusion, it is advised to place miniscrew between the roots of central and lateral incisors with the force applied at a right angle to the archwire between these two teeth. PMID:26636119

  7. An anterior tooth size comparison in unilateral and bilateral congenitally absent maxillary lateral incisors.

    PubMed

    Baidas, Laila; Hashim, Hayder

    2005-02-15

    The purpose of this study is to compare the anterior tooth size width in patients with congenitally missing maxillary lateral incisors using the Bolton Index and divine proportion. The study sample consisted of thirty pairs of orthodontic models with unilateral (twelve patients; 7 females, 5 males) and bilateral (eighteen patients; 13 females, 5 males) absence of maxillary lateral incisors. The mean ages of the selected cases were 17.7 and 17.5 years, respectively. Descriptive statistics were used for the data analysis. The result showed the mean of the Bolton Index in cases with bilateral absence was closer to the Bolton mean than in cases with unilateral absence. In the unilateral absence cases the width of the existing lateral incisor (5.5 mm) was an average of 1.00 mm less compared to the standard mean (6.5 mm). The divine proportion showed the maxillary central incisors were small in width as indicated by the adjusted value or they were slightly larger in width than the mandibular central incisors. In cases with unilateral and bilateral absence the Bolton Index exhibited maxillary insufficiency, which was confirmed by evaluating the divine proportion of the maxillary and mandibular incisors. The result of the present study will be of great help to both the orthodontist, whether to open or close the space, and to the prosthodontist to restore the missing teeth of patients having missing maxillary lateral incisors. PMID:15719077

  8. Ectopic eruption of permanent incisors after predecessor pulpectomy: five cases.

    PubMed

    Tannure, Patricia Nivoloni; Fidalgo, Tatiana Kelly da Silva; Barcelos, Roberta; Gleiser, Rogerio; Primo, Laura Guimaraes

    2011-01-01

    Pulpectomy in primary teeth is a common technique that preserves teeth in the oral environment and maintains or recovers periapical tissues to a healthy condition. This article describes the ectopic eruption of permanent incisors whose primary predecessors underwent pulpectomy using ZOE filler paste. In a group of 135 teeth that received pulpectomy therapy due to caries, 10 primary maxillary incisors had overretention and were followed for at least 3.5 years (mean time of 4.2 years), both clinically and radiographically, until the permanent teeth erupted. The proposed treatment included extraction of the overretained primary incisors based on permanent successor eruption chronology and contralateral eruption. Seven permanent teeth erupted ectopically. Autocorrection of the permanent tooth positions was observed in five cases. It can be concluded that periodic clinical and radiographic assessments are essential to verify radicular and filling paste resorptions and to avoid overretention and any subsequent malocclusion. PMID:21903556

  9. [Incisor repositioning: a new approach in orthodontics].

    PubMed

    Dallel, Ines; Khemiri, Mourad; Fathallah, Safa; Ben Rejeb, Salwa; Tobji, Samir; Ben Amor, Adel

    2015-12-01

    Lower incisors axis has a "key" position in different cephalometric analysis. However, several critics are directed towards the cephalometric profile and cephalometric landmarks (point, line and angle). The published norms and the cephalometric standards recommended for the optimal positioning of incisors could only be used as general clinical guidelines. Incisor repositioning to achieve optimal facial aesthetics requires taking into consideration the hard and soft tissues of the face, the profile, the muscular dynamics as well as the facial growth. In this work, we propose a new approach of incisor repositioning taking into account the variability of periodontal, functional and aesthetic factors. PMID:26655419

  10. A comparative study of incisor procumbency and mandibular morphology in vampire bats.

    PubMed

    Davis, Jillian S; Nicolay, Christopher W; Williams, Susan H

    2010-07-01

    The three species of vampire bats (Phyllostomidae: Desmodontinae), Desmodus rotundus, Diaemus youngi, and Diphylla ecaudata, are the only mammals that obtain all nutrition from vertebrate blood (sanguinivory). Because of the unique challenges of this dietary niche, vampire bats possess a suite of behavioral, physiological, and morphological specializations. Morphological specializations include a dentition characterized by small, bladelike, non-occlusive cheek teeth, large canines, and extremely large, procumbent, sickle-shaped upper central incisors. The tips of these incisors rest in cuplike pits in the mandible behind the lower incisors (mandibular pits). Here, we use microCT scanning and high-resolution radiography to describe the morphology of the mandible and anterior dentition in vampire bats, focusing on the relationship between symphyseal fusion, mandibular pit size, incisor size, and procumbency. In Desmodus and Diaemus, highly procumbent upper incisors are associated with relatively small mandibular pits, an unfused mandibular symphysis with substantial bony interdigitations linking the dentaries, and a diastema between the lower central incisors that helps to facilitate the lapping of blood from a wound. In Diphylla, less procumbent upper incisors are associated with relatively large mandibular pits, a completely fused mandibular symphysis, and a continuous lower toothrow lacking a central diastema. We hypothesize that symphyseal morphology and the presence or absence of the diastema are associated with the angle of upper incisor procumbency and mandibular pit development, and that spatial constraints influence the morphology of the symphysis. Finally, this morphological variation suggests that Diphylla utilizes a different feeding strategy as compared to Desmodus and Diaemus, possibly resulting from the functional demands of specialization on avian, rather than mammalian, blood. PMID:20544874

  11. Giant cementoblastoma of the impacted mandibular incisor.

    PubMed

    Karaal, Naci; Agdo?an, zgr; Livao?lu, Murat; Uralo?lu, Muhammet; zel, Birol

    2011-11-01

    The cementoblastoma is a relatively rare type of all odontogenic tumors. The incisor and impacted or unerupted tooth involvement by a cementoblastoma is extremely rare. We present a case report of a giant cementoblastoma that involved an impacted mandibular incisor. PMID:22134313

  12. Incisor wear and age in Yellowstone bison

    USGS Publications Warehouse

    Christianson, D.A.; Gogan, P.J.P.; Podruzny, K.M.; Olexa, E.M.

    2005-01-01

    Biologists commonly use tooth eruption and wear patterns or cementum annuli techniques to estimate age of ungulates. However, in some situations the accuracy or sampling procedures of either approach are undesirable. We investigated the progression of several quantitative measures of wear with age, using permanent first incisors from Yellowstone bison (Bison bison), and tested for differences between sexes and herds. We further investigated the relationship of wear and age to explore an age-estimation method. Labial-lingual width (LLW) correlated best with assigned age (r2=0.66, males; r2=0.76 females). Labial-lingual width differed between sexes, with females showing ?0.2 mm more wear than males. Additionally, differences in rate of wear existed between bison of the northern and central Yellowstone herds (1.2 and 0.9 mm/year, respectively). We developed a regression formula to test the power of LLW as an estimator of Yellowstone bison age. Our method provided estimated ages within 1 year of the assigned age 73% and 82% of the time for female and male bison, respectively.

  13. Biomechanical considerations in mandibular incisor extraction cases.

    PubMed

    Rachala, Madhukar Reddy; Aileni, Kaladhar Reddy; Dasari, Arun Kumar; Sinojiya, Jay

    2015-01-01

    Mandibular incisor extraction can be regarded as a valuable treatment option in certain malocclusions to obtain excellence in orthodontic results in terms of function, aesthetics and stability. This treatment alternative is indicated in clinical situations like mild to moderate class III malocclusion, mild anterior mandibular tooth size excess, periodontally compromised teeth, ectopic eruption of mandibular incisor and minimal openbite tendencies. Unlike in premolar extraction cases, space closure in mandibular incisor extraction cases is unique in which the extraction space will be in the middle of the arch. The end result of space closure in these cases should be well aligned, upright, anterior teeth with parallel roots and the goal can be achieved with the bodily tooth movement through proper application of biomechanics. The purpose of this article is to explain the biomechanics of space closure in mandibular incisor extraction cases. PMID:25881386

  14. Management of horizontally impacted dilacerated lateral incisor

    PubMed Central

    Katta, Anil Kumar; Peddu, Revathi; Vannala, Venkataramana; Dasari, Vaishnavi

    2015-01-01

    Impaction of maxillary lateral incisor with odontome and retained deciduous tooth is not often seen in regular dental practice. Impaction of anterior teeth cause generalized spacing which affects the esthetics of the face. Here we report a case of an 18-year-old patient with horizontally impacted dilacerated lateral incisor, which was bought into occlusion with the help of orthodontic tooth movement within a span of 18 months. PMID:26538954

  15. Clinical management of a fused mandibular lateral incisor with supernumerary tooth: A case report

    PubMed Central

    Aydemir, Seda; Ozel, Emre; Arukaslan, Goze; Tekce, Neslihan

    2016-01-01

    The purpose of this report is to present a rare case of a fused mandibular lateral incisor with supernumerary tooth with a follow-up for 18-months. A 35-year-old female patient was referred to our clinic with an extraoral sinus tract in the chin. The intraoral diagnosis revealed the fusion of her mandibular lateral incisors. Vitality pulp tests were negative for mandibular right central and lateral incisors. Radiographic examinations showed a fused tooth with two separate pulp chambers, two distinct roots, and two separate root canals. There were also periapical lesion of fused teeth and mandibular right central incisor, so endodontic treatment was carried out the related teeth. Radiographic examination revealed a complete healing of the lesion postoperatively at the end of 18-months. This paper reports the successful endodontic and restorative treatment of unilateral fused incisors. Because of the abnormal morphology of the crown and the complexity of the root canal system in fused teeth, treatment protocols require special attention. PMID:26962321

  16. Removable orthodontic appliance with nickel-titanium spring to reposition the upper incisors in an autistic patient.

    PubMed

    Saito, Kan; Jang, Insan; Kubota, Kazumi; Hoshino, Tomonori; Hotokezaka, Hitoshi; Yoshida, Noriaki; Fujiwara, Taku

    2013-01-01

    A newly designed removable appliance with a shape-memory wire was used for the orthodontic treatment of the anterior teeth in an 11-year-old child who had autism and intellectual disability. The device was designed to reduce the lateral incisor crossbite and the central incisors' labial rotation. The child was treated for 1 year with this removable appliance. Tooth movement was analyzed using cephalograms and surface data were derived from study models. This device proved to be very durable. The lateral incisor crossbite was corrected, and the inclination of the upper central incisors and the interincisal angle were improved. This appliance exerts light and continuous orthodontic force, without requiring any adjustments of the spring wire. The appliance also facilitated orthodontic treatment in a child with intellectual disability in whom treatment with a standard orthodontic device would be unsuitable. PMID:23278147

  17. Deciduous molar hypomineralization and molar incisor hypomineralization.

    PubMed

    Elfrink, M E C; ten Cate, J M; Jaddoe, V W V; Hofman, A; Moll, H A; Veerkamp, J S J

    2012-06-01

    This study was embedded in the Generation R Study, a population-based prospective cohort study from fetal life until young adulthood. This study focused on the relationship between Deciduous Molar Hypomineralization (DMH) and Molar Incisor Hypomineralization (MIH). First permanent molars develop during a period similar to that of second primary molars, with possible comparable risk factors for hypomineralization. Children with DMH have a greater risk of developing MIH. Clinical photographs of clean, moist teeth were taken with an intra-oral camera in 6,161 children (49.8% girls; mean age 74.3 mos, SD 5.8). First permanent molars and second primary molars were scored with respect to DMH or MIH. The prevalence of DMH and MIH was 9.0% and 8.7% at child level, and 4.0% and 5.4% at tooth level. The Odds Ratio for MIH based on DMH was 4.4 (95% CI, 3.1-6.4). The relationship between the occurrence of DMH and MIH suggests a shared cause and indicates that, clinically, DMH can be used as a predictor for MIH. PMID:22370445

  18. Precision of marginal adaptation of the incisor and molar Procera allceram crown copings.

    PubMed

    Pilathadka, S; Slezk, R; Srinivasan, V; Ivanckov, R

    2008-01-01

    The primary objective of this in vitro study was to compare the absolute marginal discrepancy (AMD) of CAD/CAM produced Procera AllCeram crown copings, fabricated on die stone master models of two different tooth groups, incisor and molar. Two maxillary central incisors and two first molars typodont teeth were prepared with 0.8 mm of circumferential chamfer, duplicated 9 times to obtain 36 die stone models and allotted into three groups of 12 models (incisors = 6 & molars = 6). Procera AllCeram 0.6 mm copings were fixed with zinc phosphate (AZ), glass ionomer (AG) and resin (AR) cement accordingly under 50 N static finger force. The AMDs were measured using the scanning electron microscope (SEM) on four axial walls with 4 measurements on each wall to obtain 16 readings for one tooth. Statistical analysis of the data was performed using the non-parametric test of Kruskal-Wallis and Mann-Whitney test. The analysis did not find any significant differences in the mean AMD of incisor and molar crown copings, and in different axial surfaces too (p < or = 0.05). Recorded mean AMD of incisor copings were AZ group 59 microm, AG 37.9 microm, and AR 44.4 microm and molar copings were AZ 48.8 microm, AG 27 microm, and AR 50.2 microm. It can be concluded that AMD of Procera AllCeram copings were within accepted level of 100 microm. Incisors showed higher AMD than molars. Molars demonstrated the higher AMD on mid-distal and mid-lingual surfaces whereas for incisor it was mid-buccal and mid-lingual surface. PMID:19097392

  19. Age estimation from pulp/tooth area ratio in maxillary incisors among Egyptians using dental radiographic images.

    PubMed

    Zaher, Jaklin Fekri; Fawzy, Irene Atef; Habib, Sahar Refaat; Ali, Magdy Mohamed

    2011-02-01

    Age estimation from dental radiographs is a non-destructive, simple method to obtain information. The aim of this study was to determine the reliability of age estimation from Egyptians' incisors radiographs. 144 periapical radiographs of maxillary (central & lateral) incisors (both sexes) aged 12-60 were used. Digital camera was used to image the radiographs. Images were computed and pulp/tooth area ratios were determined by AutoCAD Program. Data were subjected to correlation and regression analysis which showed statistically significant correlation (r=0.23 &P=0.006 for maxillary central incisors and r=-0.2 &P=0.05 for maxillary lateral incisors) between age and pulp tooth area ratio. Linear regression equations were determined separately for both central and lateral incisors along with the corresponding Standard Error of Estimate, which ranged from 1.2 to 5.08 years. Consequently, it was concluded that pulp/tooth area ratios of incisors are reliable for estimation of age among Egyptians in forensic work. PMID:21315299

  20. Surgical Derotation Technique: A Novel Approach in the Management of Rotated Immature Permanent Incisor

    PubMed Central

    Krishnapriya, V; Sriram, CH; Reddy, Maheshwar KR

    2015-01-01

    ABSTRACT Surgical derotation is a method of placing a rotated tooth in normal alignment in a dental arch; surgically, immediately and permanently. It is a potentially convenient and cost-effective treatment modality as compared to conventional orthodontic procedure for rotated maxillary incisor with open apex. Here is a presentation of a severely rotated maxillary left permanent central incisor in a nine and half years old girl, with a radiographic evidence of immature root apex which was surgically derotated, orthodontically retroclined and intruded to its normal position. Postsurgical clinical and radiographic evaluation was done for a period of one and half years to confirm the vitality and continued physiological root formation of the affected tooth. How to cite this article: Dutta B, Krishnapriya V, Sriram CH, Reddy MKR. Surgical Derotation Technique: A Novel Approach in the Management of Rotated Immature Permanent Incisor. Int J Clin Pediatr Dent 2015;8(3):220-223. PMID:26604541

  1. Quantum-walk-based search and centrality

    SciTech Connect

    Berry, Scott D.; Wang, Jingbo B.

    2010-10-15

    We study the discrete-time quantum-walk-based search for a marked vertex on a graph. By considering various structures in which not all vertices are equivalent, we investigate the relationship between the successful search probability and the position of the marked vertex, in particular, its centrality. We find that the maximum value of the search probability does not necessarily increase as the marked vertex becomes more central, and we investigate an interesting relationship between the frequency of the successful search probability and the centrality of the marked vertex.

  2. [Upper lateral incisor with 2 canals].

    PubMed

    Fabra Campos, H

    1991-01-01

    Clinical case summary of the patient with an upper lateral incisor with two root canals. The suspicion that there might be an anatomic anomaly in the root that includes a complex root canal system was made when an advanced radicular groove was detected in the lingual surface or an excessively enlarged cingulum. PMID:1659854

  3. Bases for central storage units. Research report

    SciTech Connect

    Mould, A.E.; Stephen, F.R.

    1985-12-01

    Domestic central-storage units for space heating are heavy and installation advice (ECRC/R1857) assumes the loads to be uniformly spread over their base. Where this is not done and feet or parallel runners are provided, then an additional load-spreading device is necessary. The report describes how such load spreading can be achieved.

  4. Location and dimensions of access cavity in permanent incisors, canines, and premolars

    PubMed Central

    Krapež, Jana; Fidler, Aleš

    2013-01-01

    Background: Ideal access cavity assures unobstructed straight-line access to the apical third of the root canal and preserves tooth structure. Aim: The aim of the study was to determine the location and dimensions of access cavity with straight-line access in incisors, canines, and premolars and to evaluate the largest diameter of their root canals in the mesiodistal and vestibulooral direction. Materials and Methods: Twenty extracted teeth of each group were randomly selected and digitally radiographed from the mesiodistal and vestibulooral direction. Position of the straight-line access midline in relation to anatomical landmarks (incisal edges, fissures, and cusps) was recorded. The largest diameters in mesiodistal and vestibulooral direction were measured. Relative frequencies of access position and mean and standard deviation of both diameters were calculated. Results: For the anterior teeth, the predominant location of straight-line access was from incisal edge, except for maxillary central incisors, where location was equally distributed between incisal edge and oral surface. In mandibular premolars, the straight-line access was positioned vestibular from central fissure. In mesiodistal direction, the largest diameter was found for maxillary central incisors and canines (1.54 mm), while the smallest diameter was found for mandibular incisors (0.64 mm). In vestibulooral direction, the largest diameter was found for maxillary first premolar (5.28 mm), while the smallest diameter was found for maxillary lateral incisor (1.39 mm). Conclusions: Knowledge of location and size of access cavity facilitates achieving balance between straight-line access to the apical third of the root canal and preservation of tooth structure. PMID:24082567

  5. Forces that fracture teeth during extraction with mandibular premolar and maxillary incisor forceps.

    PubMed

    Ahel, V; Ćabov, T; Špalj, S; Perić, B; Jelušić, D; Dmitrašinović, M

    2015-12-01

    Our aim was to measure the forces that fracture teeth during extraction based on the effectiveness of the extraction forceps, and to compare them with data collected about forces applied to extracted teeth that did not fracture. We studied 208 patients whose teeth fractured during both the standard and our new method of extraction: maxillary incisors (n=79) extracted with forceps 1 (maxillary incisor forceps), and both maxillary (n=95) and mandibular incisors (n=34) extracted with forceps 13 (mandibular premolar forceps). Forces needed to fracture were assessed with a specially-designed instrument for measuring pressure and rotation. Mean (SD) pressure at the fracture site was significantly higher in maxillary incisors extracted with forceps 1 (1.26 (0.26) bar) then in both maxillary and mandibular incisors extracted with forceps 13 (0.96 (0.19) and 0.98 (0.16), p<0.001). Pressure at dislocation and both left and right rotation showed similar patterns. Pressure correlated to root surfaces of teeth ranging from r=0.35-0.54 but the correlation coefficients did not differ significantly between the teeth-forceps groups. Pressure was higher in fractured than in extracted teeth, and this varied from 3%-48%. In conclusion, forces that break teeth during extractions are sometimes only slightly higher than the extraction forces, so caution is needed during extraction. PMID:26346589

  6. Reattachment of fractured teeth fragments in mandibular incisors: a case report

    PubMed Central

    Yousef, Mohammed K

    2015-01-01

    The majority of dental trauma involves anterior teeth, especially the maxillary central incisors. A mandibular incisor fracture with or without pulp tissue involvement is considerably less common. Different approaches for treating these fractured teeth have been reported in the literature. The type of treatment rendered depends mainly on the extent of fracture, pulp involvement, radicular fracture, biologic width infringement or violation, and presence of the fractured piece. This case report illustrates reattachment of fractured fragments on two mandibular incisors without pulp exposure using a new proposed reattachment method using a combination of two different types of composite materials together with an orthodontic lingual retention wire. An 8-year-old female patient presented with fractured mandibular left incisors (Ellis class II fracture). Broken pieces were saved and brought in a closed container in water. Periapical radiographs revealed no evidence of pulpal involvement in either tooth and no periapical radiolucency was noticed. Fractured fragments and the broken teeth were prepared with circumferential bevels. Reattachment of the fractured fragments were done using two types of composite resin materials and a lingual orthodontic retention wire was also used. The patient was recalled after 8 months to follow up both teeth. Clinical examination revealed excellent composite restorations covering the fracture lines. PMID:25897267

  7. Reinforcement of bonded crown fractured incisors with porcelain veneers.

    PubMed

    Andreasen, F M; Daugaard-Jensen, J; Munksgaard, E C

    1991-04-01

    A method is described by which porcelain laminate veneers are used to reinforce crown-fractured incisors which have been restored by reattachment of enamel-dentin fragments using enamel etching and a dentin bonding system. In an experimental model using sheep incisors, it was found that fracture strength equal to that of intact incisors could be achieved by employing this method. This is in contrast to fracture strengths of reattached enamel-dentin tooth fragments without porcelain laminates which were only 50% of intact incisors. It is suggested that porcelain laminate veneers may be used to supplement fragment bonding, thereby enhancing dental esthetics and function. PMID:1782899

  8. Current controversies in late incisor crowding.

    PubMed

    Samspon, W J

    1995-01-01

    Although the terminology is mildly controversial, late incisor crowding (tertiary crowding, late secondary crowding, post-adolescent crowding) is widely regarded as a normal maturation event which is likely to affect most individuals to some extent. Disagreement arises when attempts are made to quantify the change and to predict the timing of the crowding. Most young adults experience some degree of loss of incisor alignment, usually near the anticipated emergence time for the third molars, and almost characteristically it is the lower anterior teeth which best demonstrate the phenomenon. Unfortunately, the physiological crowding changes are frequently confused with orthodontic treatment relapse. Greater controversy surrounds the aetiology of the undesirable crowding changes and despite many attempts we are still not in the enlightened position of explaining, predicting or preventing the problem (except by permanent retention). It is illogical to assume a single cause as the beguilingly simple observation of crowding belies the complexity of possible interacting factors. Perhaps it is a capricious combination of: tooth size and arch form; facial growth pattern (differential soft tissue and skeletal maturation); continuing late growth rotations; cumulative effects of resting, functional and parafunctional soft tissue pressures; lack of compensating attrition; and an ill-defined, mesially acting force emanating from the back of the dental arch. Many theories have attempted to resolve the mystery of the mesially acting force, including: pressure from erupting third molars; an inherent mesial migration; continuing mesial and occlusal dental drifting; maturation and contraction of periodontal soft tissues (particularly the transseptal fibres); the anterior component of occlusal forces; and the lower anterior arch contracting influence of the incisor overbite.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7605082

  9. In vivo administration of dental epithelial stem cells at the apical end of the mouse incisor

    PubMed Central

    Orsini, Giovanna; Jimenez-Rojo, Lucia; Natsiou, Despoina; Putignano, Angelo; Mitsiadis, Thimios A.

    2015-01-01

    Cell-based tissue regeneration is an attractive approach that complements traditional surgical techniques for replacement of injured and lost tissues. The continuously growing rodent incisor provides an excellent model system for investigating cellular and molecular mechanisms that underlie tooth renewal and regeneration. An active population of dental epithelial progenitor/stem cells located at the posterior part of the incisor, commonly called cervical loop area, ensures the continuous supply of cells that are responsible for the secretion of enamel matrix. To explore the potential of these epithelial cells in therapeutic approaches dealing with enamel defects, we have developed a new method for their in vivo administration in the posterior part of the incisor. Here, we provide the step-by-step protocol for the isolation of dental epithelial stem cells and their delivery at targeted areas of the jaw. This simple and yet powerful protocol, consisting in drilling a hole in the mandibular bone, in close proximity to the cervical loop area of the incisor, followed up by injection of stem cells, is feasible, reliable, and effective. This in vivo approach opens new horizons and possibilities for cellular therapies involving pathological and injured dental tissues. PMID:25914649

  10. In vivo administration of dental epithelial stem cells at the apical end of the mouse incisor.

    PubMed

    Orsini, Giovanna; Jimenez-Rojo, Lucia; Natsiou, Despoina; Putignano, Angelo; Mitsiadis, Thimios A

    2015-01-01

    Cell-based tissue regeneration is an attractive approach that complements traditional surgical techniques for replacement of injured and lost tissues. The continuously growing rodent incisor provides an excellent model system for investigating cellular and molecular mechanisms that underlie tooth renewal and regeneration. An active population of dental epithelial progenitor/stem cells located at the posterior part of the incisor, commonly called cervical loop area, ensures the continuous supply of cells that are responsible for the secretion of enamel matrix. To explore the potential of these epithelial cells in therapeutic approaches dealing with enamel defects, we have developed a new method for their in vivo administration in the posterior part of the incisor. Here, we provide the step-by-step protocol for the isolation of dental epithelial stem cells and their delivery at targeted areas of the jaw. This simple and yet powerful protocol, consisting in drilling a hole in the mandibular bone, in close proximity to the cervical loop area of the incisor, followed up by injection of stem cells, is feasible, reliable, and effective. This in vivo approach opens new horizons and possibilities for cellular therapies involving pathological and injured dental tissues. PMID:25914649

  11. Dens invaginatus in a geminated maxillary lateral incisor.

    PubMed

    Pallivathukal, Renjith George; Misra, Alok; Nagraj, Sumanth Kumbargere; Donald, Preethy Mary

    2015-01-01

    Dens invaginatus (DI) and gemination are two developmental abnormalities that are well reported in the dental literature, but their coexistence in a single tooth is rare. Such situations worsen the risk factors associated with these anomalies, and the treatment plan should be customised as they possess altered morphology and anatomy. A 19-year-old girl came for evaluation of a cracked tooth in the front region of the upper jaw. The tooth showed clinical features of gemination and radiographic features of DI, and was diagnosed as DI in geminated maxillary lateral incisor. The differential diagnoses based on clinical appearance without radiographic investigation may warrant the treatment approach if these two abnormalities coexist in a single tooth. The report also highlights the importance of three-dimensional imaging in diagnosis and treatment planning of teeth with altered pulp canal anatomy. There are few reported cases in the literature detailing the treatment options for these two anomalies occurring in the same tooth. PMID:26002668

  12. Lower incisor retraction with a modified corticotomy.

    PubMed

    Germe, Derya; Giray, Bahadir; Kocadereli, Ilken; Enacar, Ayhan

    2006-09-01

    This case report demonstrates the orthodontic treatment facilitated with a new conservative corticotomy technique to shorten the treatment time during lower incisor retraction. The patient was a 22-year-old woman with protrusive profile, severe anterior crowding, an anterior crossbite, and Class III dental relationship. Orthodontic treatment consisted of the extraction of four first premolars with maximum anchorage. A modified corticotomy technique, in which the lingual vertical and subapical horizontal cuts were eliminated, was combined with orthodontic therapy for the retraction of the lower anterior teeth. Corticotomy-facilitated orthodontics dramatically reduced the treatment time without any adverse effects on the periodontium and the vitality of the teeth. The main advantages of this modified corticotomy technique were the elimination of the lingual cuts and flap, the reduction of surgery time, and minimum discomfort to the patient. At the end of active orthodontic therapy, balanced occlusion and facial esthetics were achieved. PMID:17029527

  13. An Identification Key to Rodent Prey in Owl Pellets from the Northwestern and Southeastern United States: Employing Incisor Size to Distinguish among Genera

    ERIC Educational Resources Information Center

    Hager, Stephen B.; Cosentino, Bradley J.

    2006-01-01

    We present an identification key to the common rodent prey found in owl pellets from the Northwestern (NW) and Southeastern (SE) United States that is based on differences in incisor size (arc diameter) among genera.

  14. The Adaptive Significance of Enamel Loss in the Mandibular Incisors of Cercopithecine Primates (Mammalia: Cercopithecidae): A Finite Element Modelling Study

    PubMed Central

    Kupczik, Kornelius; Lev-Tov Chattah, Netta

    2014-01-01

    In several primate groups enamel is reduced or absent from the lingual (tongue) side of the mandibular incisor crowns akin to other placental and marsupial mammalian groups such as rodents, lagomorphs and wombats. Here we investigate the presumed adaptation of crowns with unilateral enamel to the incision of tough foods in cercopithecines, an Old World monkey subfamily, using a simulation approach. We developed and validated a finite element model of the lower central incisor of the rhesus macaque (Macaca mulatta) with labial enamel only to compute three-dimensional displacements and maximum principal stresses on the crown subjected to compressive loads varying in orientation. Moreover, we developed a model of a macaque incisor with enamel present on both labial and lingual aspects, thus resembling the ancestral condition found in the sister taxon, the leaf-eating colobines. The results showed that, concomitant with experimental results, the cercopithecine crown with unilateral enamel bends predominantly towards the inside of the mouth, while displacements decreased when both labial and lingual enamel are present. Importantly, the cercopithecine incisor crown experienced lower maximum principal stress on the lingual side compared to the incisor with enamel on the lingual and labial aspects under non-axial loads directed either towards the inside or outside of the mouth. These findings suggest that cercopithecine mandibular incisors are adapted to a wide range of ingestive behaviours compared to colobines. We conclude that the evolutionary loss of lingual enamel in cercopithecines has conferred a safeguard against crown failure under a loading regime assumed for the ingestion (peeling, scraping) of tough-skinned fruits. PMID:24831704

  15. The adaptive significance of enamel loss in the mandibular incisors of cercopithecine primates (Mammalia: Cercopithecidae): a finite element modelling study.

    PubMed

    Kupczik, Kornelius; Lev-Tov Chattah, Netta

    2014-01-01

    In several primate groups enamel is reduced or absent from the lingual (tongue) side of the mandibular incisor crowns akin to other placental and marsupial mammalian groups such as rodents, lagomorphs and wombats. Here we investigate the presumed adaptation of crowns with unilateral enamel to the incision of tough foods in cercopithecines, an Old World monkey subfamily, using a simulation approach. We developed and validated a finite element model of the lower central incisor of the rhesus macaque (Macaca mulatta) with labial enamel only to compute three-dimensional displacements and maximum principal stresses on the crown subjected to compressive loads varying in orientation. Moreover, we developed a model of a macaque incisor with enamel present on both labial and lingual aspects, thus resembling the ancestral condition found in the sister taxon, the leaf-eating colobines. The results showed that, concomitant with experimental results, the cercopithecine crown with unilateral enamel bends predominantly towards the inside of the mouth, while displacements decreased when both labial and lingual enamel are present. Importantly, the cercopithecine incisor crown experienced lower maximum principal stress on the lingual side compared to the incisor with enamel on the lingual and labial aspects under non-axial loads directed either towards the inside or outside of the mouth. These findings suggest that cercopithecine mandibular incisors are adapted to a wide range of ingestive behaviours compared to colobines. We conclude that the evolutionary loss of lingual enamel in cercopithecines has conferred a safeguard against crown failure under a loading regime assumed for the ingestion (peeling, scraping) of tough-skinned fruits. PMID:24831704

  16. Management of internal resorption of central incisor using hybrid technique

    PubMed Central

    Gayathri, Prabakaran; Pandey, Ramesh Kumar; Jain, Eesha

    2014-01-01

    Internal inflammatory root resorption is characterised by progressive destruction of intraradicular dentin and dentinal tubules along the root canal wall. A number of theories have been proposed as a possible cause for internal resorption. It is usually asymptomatic and detected during routine radiographic investigations. Prompt diagnosis and early management of such defects is essential to maintain the integrity of the tooth. Non-surgical and surgical methods are the two main strategies involved in the management of internal resorption. The non-surgical method is usually preferred, but in cases of extensive resorption with external root perforation, surgical intervention has been advocated. The present case illustrates repair of perforating internal resorption by hybrid method, using mineral trioxide aggregate and gutta-percha, following surgical exposure. After a 10-month follow-up, no clinical and radiographic abnormalities were observed. Additionally, there was also marked reduction in periodontal pocket depth. PMID:24473420

  17. Management of invasive cervical resorption in a maxillary central incisor

    PubMed Central

    Kumar, S. Senthil; Kumar, N. S. Mohan; Karunakaran, J. V.; Nagendran, S.

    2015-01-01

    Invasive cervical resorption is often not diagnosed properly, leading to improper treatment or unnecessary loss of the tooth structure. Early diagnosis and appropriate treatment are the keys to a successful outcome of therapy. Invasive cervical resorption is often seen in the cervical area of the tooth, but because it is initiated apical to the epithelial attachment, it can present anywhere in the root. In the early stages, it may be symmetrical, but larger lesions have the tendency to be asymmetrical. It can expand apically or coronally. PMID:26538950

  18. Upper incisor to Soft Tissue Plane (UI-STP): a new reference for diagnosis and planning in dentofacial deformities.

    PubMed

    Hernandez-Alfaro, Federico

    2010-09-01

    Planning in orthognathic surgery has been and still is an open issue. We have evolved from 2D classical cephalometric hard-tissue planning to 2D soft tissue planning, and finally to 3D and hard and soft tissue evaluation. This, to our knowledge, is the first description of a new Soft Tissue Plane (STP) and its relationship with the anterior position of the upper incisor (UI). Profile photographs of 110 "attractive individuals" with lips at rest or smiling and with upper incisor shown were used. The photographs used were of 65 professional models from two international agencies and 45 individuals considered most attractive in the internet forums, which included catwalk models and actors. In 86 cases (78.18 %), the incisor was located in front of the STP (A). In 15 cases (13.63%), it was on the plane (N); and in the remaining 9 cases (8.18%), it was behind (P). Despite the limitations of this study and based on our series, we can conclude that the upper incisor is located at or in front of the Soft Tissue Plane (STP) in 91.81% of the attractive facial profiles studied. On the other hand, the relative position of the upper incisor to the soft tissue plane (UI-STP) could be a useful diagnostic and planning tool in orthodontic and surgical management of dentofacial deformities. PMID:20383095

  19. Morphology of Mandibular Incisors: A Study on CBCT

    PubMed Central

    Kamtane, Smita; Ghodke, Monali

    2016-01-01

    Summary Background The aim of the study was to identify the number of root canals and examine root canal morphology of permanent mandibular incisors in an Indian sub-population of Pune, Maharashtra, India using cone-beam computed tomography (CBCT). Material/Methods This study was conducted at Elite CBCT & Dental Diagnostics, Pune. One hundred mandibular incisors were evaluated for the number of root, root canals and root morphology. Results In the present study, amongst 102 mandibular incisors, all had one root, 36% of them had a second canal, and Vertucci Type I was the most common type. Conclusions CBCT imaging is an excellent method for detection of different canal configurations of mandibular incisors. PMID:26834865

  20. Onset of molar incisor hypomineralization (MIH).

    PubMed

    Fagrell, Tobias G; Salmon, Phil; Melin, Lisa; Norn, Jrgen G

    2013-01-01

    The etiological factors and timing of the onset of molar incisor hypomineralization (MIH) are still not clear. The aim of this study was to examine ground radial and sagittal sections from teeth diagnosed with MIH using light microscopy, polarized light microscopy and X-ray micro-computed tomography (XMCT) and to estimate the onset and timing of the MIH and to relate the hypomineralized enamel to the incremental lines. Thirteen extracted permanent first molars diagnosed MIH, were analyzed with light microscopy and XMCT. The hypomineralized areas were mainly located in the mesio-buccal cusps, starting at the enamel-dentin-junction and continuing towards the enamel surface. In a relative gray scale analysis the values decreased from the EDJ towards the enamel surface. The findings indicate that the ameloblasts in the hypomineralized enamel are capable of forming an enamel of normal thickness, but with a substantial reduction of their capacity for maturation of enamel. Chronologically, it is estimated that the timing of the disturbance is at a period during the first 6-7 months of age. PMID:23957140

  1. Electron microprobe analyses of Ca, S, Mg and P distribution in incisors of Spacelab-3 rats

    NASA Technical Reports Server (NTRS)

    Rosenberg, G. D.; Simmons, D. J.

    1985-01-01

    The distribution of Ca, S, Mg and P was mapped within the incisors of Spacelab-3 rats using an electron microprobe. The data indicate that Flight rats maintained in orbit for 7 days have significantly higher Ca/Mg ratios in dentin due to both higher Ca and lower Mg content than in dentin of ground-based Controls. There is no statistical difference in distribution of either P or S within Fligth animals and Controls, but there is clear indication that, for P at least, the reason is the greater variability of the Control data. These results are consistent with those obtained on a previous NASA/COSMOS flight of 18.5 days duration, although they are not pronounced. The results further suggest that continuously growing rat incisors provide useful records of the effects of weightlessness on Ca metabolism.

  2. Esthetic and biologic mode of reattaching incisor fracture fragment utilizing glass fiber post

    PubMed Central

    Manju, M.; Shanthraj, Srinivas L.; Savitha, K. C.; Sethi, Ntasha

    2015-01-01

    Trauma to the anterior teeth affects the esthetic and psychological well-being of the patient. Advancement in the adhesive dentistry has facilitated the restoration of the coronal tooth fractures by minimally invasive procedures when the original tooth fragment is available. Reattachment of fractured fragment offers immediate treatment with improved preponderant aesthetics and restoration of function. Here, we describe a case of complicated fracture of the maxillary left immature permanent central incisor, which was treated endodontically followed by esthetic reattachment of the fractured fragment using the glass fiber post. Functional demands and esthetic considerations of the patient were fully met with this biologic mode of fragment reattachment. PMID:26283849

  3. Esthetic and biologic mode of reattaching incisor fracture fragment utilizing glass fiber post.

    PubMed

    Manju, M; Shanthraj, Srinivas L; Savitha, K C; Sethi, Ntasha

    2015-01-01

    Trauma to the anterior teeth affects the esthetic and psychological well-being of the patient. Advancement in the adhesive dentistry has facilitated the restoration of the coronal tooth fractures by minimally invasive procedures when the original tooth fragment is available. Reattachment of fractured fragment offers immediate treatment with improved preponderant aesthetics and restoration of function. Here, we describe a case of complicated fracture of the maxillary left immature permanent central incisor, which was treated endodontically followed by esthetic reattachment of the fractured fragment using the glass fiber post. Functional demands and esthetic considerations of the patient were fully met with this biologic mode of fragment reattachment. PMID:26283849

  4. A comparative study of different intrusion methods and their effect on maxillary incisors

    PubMed Central

    Goel, Prachi; Tandon, Ragni; Agrawal, Kaushal Kishor

    2014-01-01

    Introduction To evaluate and compare the rate of intrusion and root resorption of maxillary incisors by three different intrusion techniques: Rickett's utility arch, Kalra's Simultaneous Intrusion & Retraction arch and arch with Reverse Curve of Spee. Methods The study was conducted over 30 patients aged between 14 and 25yrs with deep bite requiring at least 24mm intrusion of maxillary incisors. These patients were equally divided into three groups based on intrusion technique used, Rickets utility arch (Group I), K-SIR arch (Group II) and RCS arch (Group III). For each patient, amount of intrusion and root resorption occurring during intrusion was measured. Seven angular and six linear cephalometric measurements were made to evaluate skeletal and dental changes before and after incisor intrusion. Results The mean true incisor intrusion achieved with utility arch was 1.6mm, with K-SIR, 1.25mm and with RCS, 0.70mm respectively. The rate of intrusion of utility arch was 0.44mm/month, K-SIR 0.33mm/month, RCS 0.35mm/month, the difference was not statistically significant (p=0.451). Utility arch had significantly higher mean root resorption of 1.56mm as compared to K-SIR of 1.08mm and RCS of 0.96mm. Conclusion Both the intrusion rate and root resorption is more by utility arch while with K-SIR arch, though the rate of intrusion is almost same; the root resorption is much less. PMID:25737942

  5. Orthodontic treatment of a mandibular incisor extraction case with invisalign.

    PubMed

    Zawawi, Khalid H

    2014-01-01

    Mandibular incisor extraction for orthodontic treatment is considered an unusual treatment option because of the limited number of patients that meet the criteria for such treatment. Accurate diagnosis and treatment planning is essential to achieve the desired results. Adult orthodontic patients are increasingly motivated by esthetic considerations and reject the idea of conventional fixed appliances. In recent years, Invisalign appliances have gained tremendous attention for orthodontic treatment of adult patients to meet their esthetic demands. In this case report, a case of Class I malocclusion was treated with mandibular incisor extraction using the Invisalign appliance system. Successful tooth alignment of both arches was achieved. The use of Invisalign appliance is an effective treatment option in adult patients with Class I malocclusion that requires incisor extraction due to moderate to severe mandibular anterior crowding. PMID:25024852

  6. Orthodontic Treatment of a Mandibular Incisor Extraction Case with Invisalign

    PubMed Central

    Zawawi, Khalid H.

    2014-01-01

    Mandibular incisor extraction for orthodontic treatment is considered an unusual treatment option because of the limited number of patients that meet the criteria for such treatment. Accurate diagnosis and treatment planning is essential to achieve the desired results. Adult orthodontic patients are increasingly motivated by esthetic considerations and reject the idea of conventional fixed appliances. In recent years, Invisalign appliances have gained tremendous attention for orthodontic treatment of adult patients to meet their esthetic demands. In this case report, a case of Class I malocclusion was treated with mandibular incisor extraction using the Invisalign appliance system. Successful tooth alignment of both arches was achieved. The use of Invisalign appliance is an effective treatment option in adult patients with Class I malocclusion that requires incisor extraction due to moderate to severe mandibular anterior crowding. PMID:25024852

  7. Characteristics of incisor-premolar hypodontia in families.

    PubMed

    Arte, S; Nieminen, P; Apajalahti, S; Haavikko, K; Thesleff, I; Pirinen, S

    2001-05-01

    Nonsyndromic tooth agenesis is a genetically and phenotypically heterogenous condition. It is generally assumed that different phenotypic forms are caused by different mutated genes. We analyzed inheritance and phenotype of hypodontia and dental anomalies in 214 family members in three generations of 11 probands collected for genetic linkage study on incisor-premolar hypodontia (IPH). Our analysis confirms the autosomal-dominant transmission with reduced penetrance of IPH. The prevalence of hypodontia and/or peg-shaped teeth was over 40% in first- and second-degree relatives and 18% in first cousins of the probands. Four of nine noted obligate carriers of hypodontia gene had dental anomalies, including small upper lateral incisors, ectopic canines, taurodontism, and rotated premolars. These anomalies were also observed at higher than normal frequency in relatives affected with hypodontia. We conclude that incisor-premolar hypodontia is a genetic condition with autosomal-dominant transmission and that it is associated with several other dental abnormalities. PMID:11437217

  8. Management of Ectopically Erupting Maxillary Incisors: A Case Series.

    PubMed

    Suresh, Kotumachagi Sangappa; Uma, H L; Nagarathna, J; Kumar, Pravin

    2015-01-01

    Eruption disturbances related to the position include ectopic eruption and transpositions. The occurrence of ectopic eruption is most commonly associated with maxillary incisors. The normal eruption, position and morphology of these teeth are crucial to craniofacial development, facial esthetics as well as phonetics. It is essential that the clinicians have thorough knowledge of the eruption disturbances in order to make an appropriate, as well as timely intervention, as dictated by the complexity of the problem. How to cite this article: Suresh KS, Uma HL, Nagarathna J, Kumar P. Management of Ectopically Erupting Maxillary Incisors: A Case Series. Int J Clin Pediatr Dent 2015;8(3):227-233. PMID:26604543

  9. Management of Ectopically Erupting Maxillary Incisors: A Case Series

    PubMed Central

    Suresh, Kotumachagi Sangappa; Uma, HL; Nagarathna, J

    2015-01-01

    ABSTRACT Eruption disturbances related to the position include ectopic eruption and transpositions. The occurrence of ectopic eruption is most commonly associated with maxillary incisors. The normal eruption, position and morphology of these teeth are crucial to craniofacial development, facial esthetics as well as phonetics. It is essential that the clinicians have thorough knowledge of the eruption disturbances in order to make an appropriate, as well as timely intervention, as dictated by the complexity of the problem. How to cite this article: Suresh KS, Uma HL, Nagarathna J, Kumar P. Management of Ectopically Erupting Maxillary Incisors: A Case Series. Int J Clin Pediatr Dent 2015;8(3):227-233. PMID:26604543

  10. Three-dimensional evaluation of upper anterior alveolar bone dehiscence after incisor retraction and intrusion in adult patients with bimaxillary protrusion malocclusion*

    PubMed Central

    Guo, Qing-yuan; Zhang, Shi-jie; Liu, Hong; Wang, Chun-ling; Wei, Fu-lan; Lv, Tao; Wang, Na-na; Liu, Dong-xu

    2011-01-01

    Objective: The purpose of this study was to evaluate three-dimensional (3D) dehiscence of upper anterior alveolar bone during incisor retraction and intrusion in adult patients with maximum anchorage. Methods: Twenty adult patients with bimaxillary dentoalveolar protrusion had the four first premolars extracted. Miniscrews were placed to provide maximum anchorage for upper incisor retraction and intrusion. A computed tomography (CT) scan was performed after placement of the miniscrews and treatment. The 3D reconstructions of pre- and post-CT data were used to assess the dehiscence of upper anterior alveolar bone. Results: The amounts of upper incisor retraction at the edge and apex were (7.641.68) and (3.912.10) mm, respectively, and (1.340.74) mm of upper central incisor intrusion. Upper alveolar bone height losses at labial alveolar ridge crest (LAC) and palatal alveolar ridge crest (PAC) were 0.543 and 2.612 mm, respectively, and the percentages were (6.493.54)% and (27.429.77)%, respectively. The shape deformations of LAC-labial cortex bending point (LBP) and PAC-palatal cortex bending point (PBP) were (15.375.20) and (6.433.27), respectively. Conclusions: Thus, for adult patients with bimaxillary protrusion, mechanobiological response of anterior alveolus should be taken into account during incisor retraction and intrusion. Pursuit of maximum anchorage might lead to upper anterior alveolar bone loss. PMID:22135148

  11. Localized periodontal defect associated with unusual furcation involvement on a mandibular incisor.

    PubMed

    Kwon, TaeHyun; Intini, Giuseppe; Kim, David M; Levin, Liran

    2013-10-01

    A localized periodontal defect associated with an unusual furcation on a mandibular central incisor and its treatment sequences are presented. A 54-year-old woman presented with a persistent localized periodontal defect, which was not responsive to nonsurgical periodontal therapy. An exploratory surgery revealed complete through and through furcation involvement on the right mandibular central incisor, resulting in a three-walled infrabony defect. Following thorough mechanical debridement and root planing, the infrabony aspect of the defect was grafted with freeze-dried bone allograft combined with the recombinant human platelet-derived growth factor-BB. The flaps were positioned to enable patient's home care and professional dental cleaning. Follow-up examination revealed uneventful healing and resolution of the infrabony periodontal defect. Clinicians should be aware of this unusual condition and consider it as a potential etiology when dealing with a persistent localized periodontal defect in the mandibular anterior sextant, which may not respond to the conventional nonsurgical periodontal therapy. Eliminating the active disease as well as enabling careful maintenance and oral hygiene may prevent further deterioration and result in a stable long-term outcome preserving the compromised tooth. PMID:23878844

  12. Nonsurgical Endodontic Management of a Molar-Incisor Malformation-affected Mandibular First Molar: A Case Report.

    PubMed

    Yue, Wonyoung; Kim, Euiseong

    2016-04-01

    A molar-incisor malformation (MIM) is a newly reported type of dental anomaly that involves a characteristic root malformation in permanent first molars and deciduous second molars and a crown defect in permanent central incisors. This case report describes a nonsurgical root canal treatment of a MIM-affected molar by aid of a reformatted axial view of the tooth cone-beam computed tomography (CBCT). A MIM-affected molar has calcified canal orifices and a few immature accessory furcal canals. Conventional root canal treatment with the aid of CBCT followed by resin restoration was performed on the tooth. The malformed roots of MIM teeth generally make it difficult to apply conventional endodontic treatment; however, it was possible to do with the aid of the reformatted axial view of the CBCT. PMID:26706790

  13. Talon cusps occurring concurrently with dens invaginatus on a permanent maxillary lateral incisor: a case report and literature review.

    PubMed

    Colak, Hakan; Yilmaz, Cicek; Keklik, Hakan; Colak, Tugba

    2014-01-01

    A talon cusp is a prominent accessory horn-like structure that projects from the cingulum or cementoenamel junction of the maxillary or mandibular teeth. It can occur in primary and permanent dentition and can lead to occlusal interference, irritation of the tongue, pulpal necrosis, caries, and periodontal problems. Talon cusp has been reported to affect both sexes, and may be unilateral or bilateral. Talon cusps occur most often on the palatal surface of permanent maxillary incisors. A comprehensive literature review revealed only 6 reported cases of facial talon cusps. A talon cusp occurring simultaneously with dens invaginatus in a tooth is extremely rare; to date, only 9 case reports have been published. This article presents a unique case of concurrent dens invaginatus and palatal and facial talon cusps in the right maxillary central incisor of a 12-year-old girl. PMID:24784523

  14. Factors associated with molar incisor hypomineralization in Thai children.

    PubMed

    Pitiphat, Waranuch; Luangchaichaweng, Sarunporn; Pungchanchaikul, Patimaporn; Angwaravong, Onauma; Chansamak, Nusara

    2014-08-01

    Molar incisor hypomineralization (MIH) is a qualitative developmental enamel defect that affects one to four permanent first molars, with or without involvement of permanent incisors. Its etiology is of systemic origin, but is not well understood. Therefore, we conducted this cross-sectional study to examine pre-, peri-, and postnatal risk factors for MIH among children, 7-8 yr of age, in urban areas of Khon Kaen, Thailand. Molar incisor hypomineralization defects were diagnosed using the European Academy of Pediatric Dentistry criteria. Mothers or primary caregivers were interviewed on maternal medical history and habits during pregnancy, pregnancy and delivery complications, and the child's medical history. Molar incisor hypomineralization defects were observed in 78 (27.7%) of 282 children. Multiple logistic regression analysis showed a statistically significant association between the development of MIH and Cesarean section (adjusted OR = 2.0, 95% CI = 1.1-3.7), complications during vaginal delivery (adjusted OR = 4.5, 95% CI = 1.9-11.0), and severe/chronic illness when under 3 yr of age (adjusted OR = 2.9, 95% CI = 1.6-5.0). There was no association of preterm birth and low birth weight with MIH. The results suggest that Cesarean section, complications during vaginal delivery, and poor health during the first 3 yr of life are independent risk factors for MIH. PMID:24924351

  15. Continuous and Short Fiber Reinforced Composite in Root Post-Core System of Severely Damaged Incisors

    PubMed Central

    Garoushi, Sufyan; Vallittu, Pekka K; Lassila, Lippo V.J

    2009-01-01

    Purpose: The aim of this study was to determine the static load-bearing capacity of endodontically treated maxillary incisors restored with post-core complex made of experimental fiber composite resin (FC) and complete crown made of particulate filler composite (PFC). Further aim was to evaluate the effect of FC resin on the failure mode of the restoration. Material and Methods: The experimental composite resin (FC) was prepared by mixing 22.5 wt% of short E-glass fibers (3 mm in length) and 22.5 wt% of semi-interpenetrating polymer network (IPN) resin with 55 wt% of silane treated silica fillers. Thirty extracted sound upper central incisors were used. Twenty teeth were prepared by cutting the clinical crown 2 mm above the cemento-enamel junction horizontally. Restorations were made by two techniques (n=10). Group A (control group) contained samples of sound incisor teeth. Group B had teeth restored using glass fiber post (everStick, Stick- Teck) and PFC (Filtek Z250, 3M-ESPE) to build up core and complete crown. In Group C, the teeth were restored with FC as post-core and complete crown of PFC. The root canals were prepared and posts were cemented with a dual cure resin cement. The restorations were polymerized with a hand-light curing unit. All restored teeth were stored in water at room temperature for 24 h before they were statically loaded with speed of 1.0 mm/min until fracture. Data were analyzed using ANOVA (p=0.05). Failure modes were visually examined. Results: ANOVA revealed that restored incisors (Group B and C) had a statistically significantly lower load-bearing capacity (p<0.05) than the control group. Restorations made from FC post-core and PFC coverage (Group C) gave force value of 363 N (112 SD), which was higher than the value of Group B (211 N, 50 SD). Conclusions: Within the limitations of this study, the teeth restored with experimental fiber composite post-core demonstrated higher load bearing capacity than those with fiber post and PFC core. PMID:19444342

  16. The Dance of Tusks: Rediscovery of Lower Incisors in the Pan-American Proboscidean Cuvieronius hyodon Revises Incisor Evolution in Elephantimorpha

    PubMed Central

    2016-01-01

    The incisors of proboscideans (tusks and tushes) are one of the most important feature in conservation, ecology and evolutionary history of these mammals. Although the absence of upper incisors is rare in proboscideans (occurring only in deinotheres), the independent losses of lower incisors are recognized for most of its lineages (dibelodont condition). The presence of lower incisors in the Pan-American gomphothere Cuvieronius hyodon was reported a few times in literature, but it was neglected in systematic studies. We analyzed several specimens of Cuvieronius hyodon from the Americas and recognized that immature individuals had lower incisors during very early post-natal developmental stages. Subsequently, these are lost and lower incisors alveoli close during later developmental stages, before maturity. Moreover, for the first time in a formal cladistic analysis of non-amebelodontine trilophodont gomphotheres, Rhynchotherium and Cuvieronius were recovered as sister-taxa. Among several non-ambiguous synapomorphies, the presence of lower incisors diagnoses this clade. We recognize that the presence of lower incisors in Cuvieronius and Rhynchotherium is an unique case of taxic atavism among the Elephantimorpha, since these structures are lost at the origin of the ingroup. The rediscovery of the lower incisors in Cuvieronius hyodon, their ontogenetic interpretation and the inclusion of this feature in a revised phylogenetic analysis of trilophodont gomphotheres brought a better understanding for the evolutionary history of these proboscideans. PMID:26756209

  17. The Dance of Tusks: Rediscovery of Lower Incisors in the Pan-American Proboscidean Cuvieronius hyodon Revises Incisor Evolution in Elephantimorpha.

    PubMed

    Mothé, Dimila; Ferretti, Marco P; Avilla, Leonardo S

    2016-01-01

    The incisors of proboscideans (tusks and tushes) are one of the most important feature in conservation, ecology and evolutionary history of these mammals. Although the absence of upper incisors is rare in proboscideans (occurring only in deinotheres), the independent losses of lower incisors are recognized for most of its lineages (dibelodont condition). The presence of lower incisors in the Pan-American gomphothere Cuvieronius hyodon was reported a few times in literature, but it was neglected in systematic studies. We analyzed several specimens of Cuvieronius hyodon from the Americas and recognized that immature individuals had lower incisors during very early post-natal developmental stages. Subsequently, these are lost and lower incisors alveoli close during later developmental stages, before maturity. Moreover, for the first time in a formal cladistic analysis of non-amebelodontine trilophodont gomphotheres, Rhynchotherium and Cuvieronius were recovered as sister-taxa. Among several non-ambiguous synapomorphies, the presence of lower incisors diagnoses this clade. We recognize that the presence of lower incisors in Cuvieronius and Rhynchotherium is an unique case of taxic atavism among the Elephantimorpha, since these structures are lost at the origin of the ingroup. The rediscovery of the lower incisors in Cuvieronius hyodon, their ontogenetic interpretation and the inclusion of this feature in a revised phylogenetic analysis of trilophodont gomphotheres brought a better understanding for the evolutionary history of these proboscideans. PMID:26756209

  18. a New Centrality Metric Based on Clustering Coefficient

    NASA Astrophysics Data System (ADS)

    Li, Chong; Guo, Shi-Ze; Lu, Zhe-Ming; Qiao, Yu-Long; Song, Guang-Hua

    2013-07-01

    Many centrality metrics have been proposed over the years to compute the centrality of nodes, which has been a key issue in complex network analysis. The most important node can be estimated through a variety of metrics, such as degree, closeness, eigenvector, betweenness, flow betweenness, cumulated nominations and subgraph. Simulated flow is a common method adopted by many centrality metrics, such as flow betweenness centrality, which assumes that the information spreads freely in the entire network. Generally speaking, the farther the information travels, the more times the information passes the geometric center. Thus, it is easy to determine which node is more likely to be the center of the geometry network. However, during information transmission, different nodes do not share the same vitality, and some nodes are more active than others. Therefore, the product of one node's degree and its clustering coefficient can be viewed as a good factor to show how active this node is. In this paper, a new centrality metric called vitality centrality is introduced, which is only based on this product and the simulated flow. Simulation experiments based on six test networks have been carried out to demonstrate the effectiveness of our new metric.

  19. A new algorithm CNM-Centrality of detecting communities based on node centrality

    NASA Astrophysics Data System (ADS)

    Hu, Fang; Liu, Yuhua

    2016-03-01

    The discovery and analysis of community structure in complex networks is a hot issue in recent years. In this paper, based on the fast greedy clustering algorithm CNM with the thought of local search, the introduction of the idea of node centrality and the optimal division of the central nodes and their neighbor nodes into correct communities, a new algorithm CNM-Centrality of detecting communities in complex networks is proposed. In order to verify the accuracy and efficiency of this algorithm, the performance of this algorithm is tested on several representative real-world networks and a set of computer-generated networks by LFR-benchmark. The experimental results indicate that this algorithm can identify the communities accurately and efficiently. Furthermore, this algorithm can also acquire higher values of modularity and NMI than the CNM, Infomap, Walktrap algorithms do.

  20. Development of clinical and radiographic signs associated with dark discolored primary incisors following traumatic injuries: a prospective controlled study.

    PubMed

    Holan, Gideon

    2004-10-01

    The purpose was to evaluate late complications of asymptomatic traumatized primary incisors with dark coronal discoloration. The clinical and radiographic signs of 97 teeth of the study group were recorded along a follow-up period that ranged between 12 and 75 months (mean >36 months). Children's age at time of injury ranged between 18 and 72 months (mean 40). The control group consisted of 102 non-discolored maxillary primary central incisors in 51 children older than 54 months with no history of dental trauma. In 50 teeth (52%) the color faded or became yellowish and in 47 (48%) it remained dark. Clinical signs of infection, that were diagnosed 5-58 months after the injury, were associated significantly more with dark than yellowish hues (83 and 17%, respectively). Teeth that had changed their color to become yellow presented more PCO than teeth with black/gray/brown coronal discoloration (78 and 6%, respectively). Arrest of dentine apposition was found in 15 teeth, one had yellow coronal discoloration and the remaining 14 had a dark shade. Eleven teeth showed inflammatory root resorption all with dark discoloration. Two atypical types of root resorption were observed: a surface resorption restricted to the lateral aspects of the apical half of the root while the root length remained unchanged and in the other expansion of the follicle of the permanent successor was observed. Expansion of the dental follicle was observed in 72% of all teeth with no significant difference between the various types of coronal discoloration but only half of the cases were associated with resorption of the root of the primary incisor. The various pathologic findings observed in the study group were either absent or rarely seen in the control group. It can be concluded that more than 50% of the primary incisors that retain their dark coronal discoloration acquired after dental injuries remain clinically asymptomatic till the eruption of the permanent successor even if they present accelerated root resorption. Asymptomatic traumatized primary incisors that retain their dark coronal discoloration may develop a sinus tract and inflammatory root resorption years after the injury. There is still a dilemma: which treatment is better for dark discolored primary incisors: early endodontic treatment or follow-up with the risk of development of infection and root resorption that may require extraction? PMID:15355387

  1. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens

    PubMed Central

    Sidiq, Mohsin; Bhat, Manohar; Sharma, Rajesh; Bhargava, Neha; Ganta, Shravani

    2015-01-01

    ABSTRACT The aim of this case study was to report a potentially convenient approach instead of a conventional orthodontic procedure for correcting severe rotation of anterior tooth of an 11-year-old Indian boy, with a mixed dentition class I malocclusion. The child reported seeking treatment for severely rotated upper right central incisor with mesiodens and a single tooth crossbite. The supernumerary tooth was first extracted and bondable buttons were placed on the rotated tooth, an appliance composed of a removable plate with Adam’s clasp with distal extension and a loop for engagement of elastics was delivered. Circumferential supracrestal fibrotomy was performed on the corrected derotated tooth. Then, Hawley’s appliance with a z-spring and posterior bite plane was fabricated and placed for correction of crossbite. Thus, this removable appliance can be a simplified and a cost-effective treatment alternative for derotation of anterior tooth, especially during the mixed dentition period. How to cite this article: Sidiq M, Yousuf A, Bhat M, Sharma R, Bhargava N, Ganta S. Correction of a Severely Rotated Maxillary Incisor by Elastics in Mixed Dentition Complicated by a Mesiodens. Int J Clin Pediatr Dent 2015;8(3):234-238. PMID:26604544

  2. Adenomatoid odontogenic tumor associated with an unerupted mandibular lateral incisor: a case report.

    PubMed

    Seo, Won-Gyo; Kim, Chul-Hwan; Park, Hae-Seo; Jang, Jong-Won; Chung, Woo-Yeol

    2015-12-01

    Adenomatoid odontogenic tumor (AOT) is a rare, benign odontogenic tumor that predominantly appears in the second decade of life in female patients. Most AOTs occur in the anterior part of the maxilla and are usually associated with impacted anterior teeth. There are three types of AOT, follicular, extrafollicular, and peripheral, which are classified based on the location of the lesion and its association with the impacted tooth. We report a rare case of AOT associated with an impacted right mandibular lateral incisor in an 11-year-old female patient. PMID:26734563

  3. Adenomatoid odontogenic tumor associated with an unerupted mandibular lateral incisor: a case report

    PubMed Central

    2015-01-01

    Adenomatoid odontogenic tumor (AOT) is a rare, benign odontogenic tumor that predominantly appears in the second decade of life in female patients. Most AOTs occur in the anterior part of the maxilla and are usually associated with impacted anterior teeth. There are three types of AOT, follicular, extrafollicular, and peripheral, which are classified based on the location of the lesion and its association with the impacted tooth. We report a rare case of AOT associated with an impacted right mandibular lateral incisor in an 11-year-old female patient. PMID:26734563

  4. Sex determination using the mesio-distal dimension of permanent maxillary incisors and canines in a modern Chilean population.

    PubMed

    Peckmann, Tanya R; Logar, Ciara; Garrido-Varas, Claudia E; Meek, Susan; Pinto, Ximena Toledo

    2016-03-01

    The pelvis and skull have been shown to be the most accurate skeletal elements for the determination of sex. Incomplete or fragmentary bones are frequently found at forensic sites however teeth are often recovered in forensic cases due to their postmortem longevity. The goal of the present research was to investigate sexual dimorphism between the mesio-distal dimension of the permanent maxillary incisors and canines for the determination of sex in a contemporary Chilean population. Three hundred and three dental models (126 males and 177 females) from individuals ranging in age from 13years to 37years old were used from the School of Dentistry, University of Chile. The statistical analyses showed that only the central incisors and canines were sexually dimorphic. Discriminant function score equations were generated for use in sex determination. The average accuracy of sex classification ranged from 59.7% to 65.0% for the univariate analysis and 60.1% to 66.7% for the multivariate analysis. Comparisons to other populations were made. Overall, the accuracies ranged from 54.4% to 63.3% with males most often identified correctly and females most often misidentified. The determination of sex from the mesio-distal width of incisors and canines in Chilean populations does not adhere to the Mohan and Daubert criteria and therefore would not be presented as evidence in court. PMID:26976465

  5. A Rare Occurrence of Geminated-Taloned Maxillary Lateral Incisor

    PubMed Central

    Kayal, Vizhi G

    2012-01-01

    ABSTRACT The talon cusp is a developmental anomaly characterized by the presence of an accessory cusp like structure projecting from the cingulum area of the anterior teeth. Gemination is an anomaly caused by a single tooth germ that attempted to divide during its development. These developmental anomalies may cause clinical problems including esthetic impairment, pain, caries and tooth crowding. Co-occurrence of two anomalies in a teeth is rare. This paper presents an unusual case of talon cusp on geminated permanent lateral incisor. How to cite this article: Neeraja R, Kayal VG. A Rare Occurrence of Geminated-Taloned Maxillary Lateral Incisor. Int J Clin Pediatr Dent 2012;5(2):136-138. PMID:25206153

  6. A rare occurrence of geminated-taloned maxillary lateral incisor.

    PubMed

    Neeraja, R; Kayal, Vizhi G

    2012-05-01

    The talon cusp is a developmental anomaly characterized by the presence of an accessory cusp like structure projecting from the cingulum area of the anterior teeth. Gemination is an anomaly caused by a single tooth germ that attempted to divide during its development. These developmental anomalies may cause clinical problems including esthetic impairment, pain, caries and tooth crowding. Co-occurrence of two anomalies in a teeth is rare. This paper presents an unusual case of talon cusp on geminated permanent lateral incisor. How to cite this article: Neeraja R, Kayal VG. A Rare Occurrence of Geminated-Taloned Maxillary Lateral Incisor. Int J Clin Pediatr Dent 2012;5(2):136-138. PMID:25206153

  7. Complete replacement resorption after replantation of maxillary incisors: report of case.

    PubMed

    Kandemir, S; Alpoz, E; Caliskan, M K; Alpoz, A R

    1999-01-01

    This article describes the treatment of a 17-year-old patient with complete root resorption of the maxillary permanent central and lateral incisors following avulsion and replantation seven years ago. The most important factor influencing the prognosis of replanted teeth is the status of the periodontal ligament (PDL). As a result of replantation, the PDL cells necrosed and tooth replacement resorption occurred. The main factors, which affected the resorption after replantation and survival of PDL cells, could be summarize as; dry extraoral time greater than 30 minutes, the kept tooth in a dry environment, touching the cementum surface, and splint treatment for a prolonged time. Since complete root resorption was found in our case, these factors probably also occurred. PMID:10551136

  8. Two betweenness centrality measures based on Randomized Shortest Paths

    NASA Astrophysics Data System (ADS)

    Kivimki, Ilkka; Lebichot, Bertrand; Saramki, Jari; Saerens, Marco

    2016-02-01

    This paper introduces two new closely related betweenness centrality measures based on the Randomized Shortest Paths (RSP) framework, which fill a gap between traditional network centrality measures based on shortest paths and more recent methods considering random walks or current flows. The framework defines Boltzmann probability distributions over paths of the network which focus on the shortest paths, but also take into account longer paths depending on an inverse temperature parameter. RSPs have previously proven to be useful in defining distance measures on networks. In this work we study their utility in quantifying the importance of the nodes of a network. The proposed RSP betweenness centralities combine, in an optimal way, the ideas of using the shortest and purely random paths for analysing the roles of network nodes, avoiding issues involving these two paradigms. We present the derivations of these measures and how they can be computed in an efficient way. In addition, we show with real world examples the potential of the RSP betweenness centralities in identifying interesting nodes of a network that more traditional methods might fail to notice.

  9. Two betweenness centrality measures based on Randomized Shortest Paths.

    PubMed

    Kivimki, Ilkka; Lebichot, Bertrand; Saramki, Jari; Saerens, Marco

    2016-01-01

    This paper introduces two new closely related betweenness centrality measures based on the Randomized Shortest Paths (RSP) framework, which fill a gap between traditional network centrality measures based on shortest paths and more recent methods considering random walks or current flows. The framework defines Boltzmann probability distributions over paths of the network which focus on the shortest paths, but also take into account longer paths depending on an inverse temperature parameter. RSP's have previously proven to be useful in defining distance measures on networks. In this work we study their utility in quantifying the importance of the nodes of a network. The proposed RSP betweenness centralities combine, in an optimal way, the ideas of using the shortest and purely random paths for analysing the roles of network nodes, avoiding issues involving these two paradigms. We present the derivations of these measures and how they can be computed in an efficient way. In addition, we show with real world examples the potential of the RSP betweenness centralities in identifying interesting nodes of a network that more traditional methods might fail to notice. PMID:26838176

  10. Two betweenness centrality measures based on Randomized Shortest Paths

    PubMed Central

    Kivimäki, Ilkka; Lebichot, Bertrand; Saramäki, Jari; Saerens, Marco

    2016-01-01

    This paper introduces two new closely related betweenness centrality measures based on the Randomized Shortest Paths (RSP) framework, which fill a gap between traditional network centrality measures based on shortest paths and more recent methods considering random walks or current flows. The framework defines Boltzmann probability distributions over paths of the network which focus on the shortest paths, but also take into account longer paths depending on an inverse temperature parameter. RSP’s have previously proven to be useful in defining distance measures on networks. In this work we study their utility in quantifying the importance of the nodes of a network. The proposed RSP betweenness centralities combine, in an optimal way, the ideas of using the shortest and purely random paths for analysing the roles of network nodes, avoiding issues involving these two paradigms. We present the derivations of these measures and how they can be computed in an efficient way. In addition, we show with real world examples the potential of the RSP betweenness centralities in identifying interesting nodes of a network that more traditional methods might fail to notice. PMID:26838176

  11. A comparative study of mandibular incisor relation to the lingual frenum in natural dentition and in complete denture wearers.

    PubMed

    Parimala, B K; Prithviraj, D R

    2012-12-01

    The determination of the occlusal vertical dimension and proper positioning of the anterior teeth are major factors in making complete dentures which will give optimum service. In this study, efforts were made to evaluate the reliability of measurement of vertical distance between the anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors in natural dentition among different age groups and in complete denture wearers. Three hundred dentulous subjects belonging to different age groups and hundred edentulous patients wearing complete dentures were selected. The dentulous group was divided into three groups, group I (20-40 years), group II (41-60 years), group III (61 years and above) and the edentulous subjects being group IV ( 40-60 years). Mandibular irreversible hydrocolloid impression (Alginate) was made using modified stock tray. In edentulous subjects impression was made with denture in position. The vertical distance between anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors was measured on the dentulous casts and casts of complete denture wearer using dental surveyor and the vernier calipers. The values were tabulated and statistically analysed. The mean vertical distance between anterosuperior most point on the lingual frenum and mesioincisal edges of mandibular central incisors among dentulous subjects was 12.3 mm and among complete denture wearers was found to be 13.2 mm. There was no significant variation in the mean vertical distance among dentulous subjects belonging to different age groups. At 5 % significance level, statistically there was a significant difference in the mean vertical distance between group I and group IV; group II and group IV. PMID:24293917

  12. Risk factors in the occurrence of molar-incisor hypomineralization amongst a group of Iraqi children.

    PubMed

    Ghanim, Aghareed; Manton, David; Bailey, Denise; Mario, Rodrigo; Morgan, Michael

    2013-05-01

    BACKGROUND.? Despite the worldwide increasing interest in the prevalence studies of molar-incisor hypomineralization (MIH), there is still insufficient evidence to verify the aetiological factors of this condition. AIMS.? To investigate risk factors involved in the development of MIH in a group of school-aged Iraqi children. DESIGN.? Seven- to nine-year-old school children (823 of 1000 eligible, response rate of 82.3%) had their first permanent molars and incisors evaluated using the European Academy of Paediatric Dentistry evaluation criteria for MIH. Mothers completed a medical history questionnaire-based interview performed in the schools by a trained examiner. RESULTS.? For children with MIH, 6% reported no relevant medical history; the remaining 94% reported various medical conditions putatively associated with MIH compared with 70% for the non-affected group. Post-natal medical conditions (33.3%) were most frequently reported. When data were split into the possible risk effect groups, maternal psychological stress (OR, 3.24), frequent exposure to ultrasonic scans during the last gestational trimester (OR, 2.51) and birth order as a fourth sibling or later (OR, 3.17 and 5.73, respectively) were previously unreported significant risk factors and postulated as contributing to, or causing the defect. CONCLUSIONS.? Children with MIH had experienced a greater number of medical conditions than their unaffected peers with no single health event identified as a risk factor. PMID:22646757

  13. Reversed palatal perforation by upper incisors in ageing blind mole-rats (Spalax ehrenbergi)

    PubMed Central

    ZURI, I.; TERKEL, J.

    2001-01-01

    Blind mole-rats (Spalax ehrenbergi) are fossorial solitary rodents that present striking morphological, physiological and behavioural adaptations to the subterranean environment in which they live. Previous studies have shown that mole-rats are specialised in tooth-digging. The rapid eruption-rate of their incisors has evolved to compensate for their excessive wear by excavation. Males use their incisors more than females for digging and fighting, and their rate of incisor eruption is significantly more rapid than in females. Since mole-rats use their incisors for digging throughout the year, we suggest that continuous mechanical pressure on their oral tissues concentrated at the apical sites of the upper incisors leads to cell and tissue fatigue. We provide evidence for 5 stages of palatal perforation by the upper incisors at their apical sites, with maximum perforation characterising aged males. Interspecies comparisons with 7 other fossorial and semi-fossorial rodent species, and with beavers, which expose their incisors to enormous mechanical pressure, revealed that this palatal perforation is unique to the male mole-rat. We suggest that while the fast eruption rate of incisors in the mole-rat compensates for the rapid wear resulting from digging, evolutionary adaptation to continuous tooth-digging is still ongoing, since the physical pressure of digging at the apical sites of the upper incisors leads to tissue destruction, breakage of the palatal bone and possibly to death, as a result of maxillary inflammation. PMID:11760890

  14. Case report: A medieval case of molar-incisor-hypomineralisation.

    PubMed

    Curzon, M E J; Ogden, A R; Williams-Ward, M; Cleaton-Jones, P E

    2015-12-18

    Introduction Molar-incisor-hypomineralisation (MIH) has been identified in recent years as a condition affecting the first permanent molars and, in some cases, the permanent incisors. Many factors have been suggested as to its aetiology. Examples of MIH have also been reported in skeletal remains in the past. These historical examples have, however, been for unknown individuals.Case report A skull that has become available for dental examination that is uncertainly attributed to be that of Lady Eleanor Talbot (c.1436-1468) who ended her life as a Carmelite nun in Norwich (England). The dental findings of the examination showed enamel defects of molar teeth 36 and 46, as well as small areas on other molars, and striations of the enamel of permanent anterior teeth consistent with MIH. There is exposure of the roots of some maxillary teeth with resultant root caries. The presence of areas of enamel decalcification commensurate with 'Turner teeth' on 43 and 44 indicates that there were likely to have been periapical abscesses secondary to dental caries of the primary teeth. In addition, there is occlusal wear of all of teeth with extensive calculus and periodontal exposure of the roots of the mandibular incisors. Failed development or very early ante-mortem loss of premolars 15 and 25 is evident, as well as evidence in the same region of a large abscess cavity with extensive maxillary bone destruction. Healing cribra orbitalia, porosity, which is considered to be an indicator of nutritional stress, is visible on the superior aspect of the left orbit.Conclusion A case of MIH is reported in a skull dating from the mid-15th century. PMID:26679138

  15. Agenesis of lateral incisors: A fresh look at our practice.

    PubMed

    Muller, Christine

    2015-12-01

    In cases involving compensation treatment for edentulousness related to agenesis of the lateral incisors, the transition phase between the orthodontic and the prosthetic stages is tricky. Using clinical illustrations, we will demonstrate that it is time we took a fresh look at our practices. The aim will be to shorten this phase either by postponing the orthodontic stage into adulthood or by placing the prosthesis as quickly as possible on completion of the orthodontic stage, a process which is now feasible, thanks to advances in the designing of bonded bridges and notably of cantilever bonded bridges. PMID:26527037

  16. Survival rate and fracture strength of incisors restored with different post and core systems and endodontically treated incisors without coronoradicular reinforcement.

    PubMed

    Pontius, Oliver; Nathanson, D; Giordano, R; Schilder, H; Hutter, Jeffrey W

    2002-10-01

    This in vitro study evaluated the survival rate and fracture resistance of maxillary central incisors restored with different post and core systems. The post and core systems investigated were a prefabricated high precious metal post with cast core (group A), zirconia post with a prefabricated bonded ceramic core (group B), and a resin-ceramic interpenetrating phase composite post (experimental) with a prefabricated bonded ceramic core (group C). The all-ceramic copings were cemented using Panavia 21 TC. In the group without coronoradicular reinforcement, the access cavity was closed with a light-cured composite in combination with a dentine-bonding agent (group D). Each specimen was intermittently loaded and thermocycled before final stress tests in a Zwick machine. The survival rates after 1,200,000 cycles in the artificial mouth were 90% (group A), 80% (group B), 60% (group C), and 100% (group D). Statistically significant differences were found between all groups with the exception of A and B, when failure during cyclic loading was included (Kruskal-Wallis multiple comparisons test). Samples restored with a cast post and core demonstrated more vertical root fractures. It was concluded that the preservation of both internal and external tooth structure is of utmost importance when restoring endodontically treated teeth. PMID:12398170

  17. Lower incisor extraction treatment with the Invisalign® technique: three case reports.

    PubMed

    Giancotti, Aldo; Garino, Francesco; Mampieri, Gianluca

    2015-03-01

    The extraction of a lower incisor can lead to satisfactory orthodontic results for patients with moderate to severe lower incisor crowding. Invisalign(®) is a treatment modality for such treatments, moving teeth with precision and reducing inconvenience for the patient. Three case reports are presented in this article supporting the above statements. PMID:25808381

  18. Endodontic Management of Three-Canalled Mandibular Lateral Incisor Using Dental Operating Microscope

    PubMed Central

    Ashwinkumar, Vijayakumar; Nandini, Suresh; Velmurugan, Natanasabapathy

    2014-01-01

    This case report presents endodontic management of a mandibular lateral incisor with three canals using surgical dental operating microscope. This study describes the root canal variation of mandibular lateral incisor and highlights the importance of surgical operating microscope in detecting an unusual canal morphology. PMID:25584063

  19. Non-linear viscoelastic finite element analysis of the effect of the length of glass fiber posts on the biomechanical behaviour of directly restored incisors and surrounding alveolar bone.

    PubMed

    Ferrari, Marco; Sorrentino, Roberto; Zarone, Fernando; Apicella, Davide; Aversa, Raffaella; Apicella, Antonio

    2008-07-01

    The study aimed at estimating the effect of insertion length of posts with composite restorations on stress and strain distributions in central incisors and surrounding bone. The typical, average geometries were generated in a FEA environment. Dentin was considered as an elastic orthotropic material, and periodontal ligament was coupled with nonlinear viscoelastic mechanical properties. The model was then validated with experimental data on displacement of incisors from published literature. Three post lengths were investigated in this study: root insertion of 5, 7, and 9 mm. For control, a sound incisor model was generated. Then, a tearing load of 50 N was applied to both sound tooth and simulation models. Post restorations did not seem to affect the strain distribution in bone when compared to the control. All simulated post restorations affected incisor biomechanics and reduced the root's deforming capability, while the composite crowns underwent a higher degree of deformation than the sound crown. No differences could be noticed in incisor stress and strain. As for the influence of post length, it was not shown to affect the biomechanics of restored teeth. PMID:18833761

  20. A cross-sectional clinical study on shape of nose inner-canthal distance and geometric progression as predictors for width of the maxillary incisor teeth

    PubMed Central

    Reddy, Naveen; Singh, T. Rajesh; Reddy, Swetha; Guruprasad, Yadavalli

    2014-01-01

    Objectives: The objective of this study is to evaluate the relationship of anatomical landmarks of the face and geometric progression as predictors for the width of the maxillary incisor teeth. Materials and Methods: The central incisor width (CIW), lateral incisor width (LIW), inner-canthal distance (ICD) and inter-alar distance (IAD) from a total of 150 subjects were measured clinically. The width of the root of the nose (WRN) was measured on standard photographs of the subjects. Student t-test has been used to find the significance of parameters between male and female. Pearson correlation has been used to find any relation of the parameters. Results: The IAD and the WRN measurements suggest that the shape of the nose is wider and more triangular in males. The mean maxillary CIW and ICD was significantly higher in males than females. Conclusion: The proportion of IAD to WRN seems to be a reliable guide for deciding the proportion of the maxillary central and LIW. The ICD, when multiplied by a decreasing function value of the geometric progression term 0.618 and divided by 2, was a reliable predictor of the maxillary CIW. PMID:25097395

  1. A web-based central diagnostic data repository.

    PubMed

    Mller, Thomas H; Adelhard, Klaus

    2002-01-01

    A central repository for diagnostic information about individual patients was created as a service to diagnostic laboratories participating in the Compentence Network for Acute and Chronic Leukemias in order to support health care delivery to patients suffering from leukemia. During the diagnostic phase several specialised laboratories perform different assays on samples from the same patient. The use of these assays in the diagnostic process and during the treatment phase may be improved in terms of both rapid delivery and cost if any one laboratory is aware of preliminary or final results from the assay carried out in other laboratories. In order to support a more efficient communication of these results, a central diagnostic data repository (CDDR) was created and web-based user interface was developed. Currently, the CDDR maintains documents in the form of portable document format (PDF) files. Several other formats are accepted and converted automatically upon entry. Patient identification is accomplished by pseudonym rather than proper name and the data is held on the CDDR for a limited time interval to accommodate the stringent privacy regulations in Germany. The principle operation of a CDDR may also be applied to the diagnostic or therapeutic process of other diseases. PMID:15460696

  2. Correction of palatally displaced maxillary lateral incisors without brackets

    PubMed Central

    Choi, Kyung-Hee; Lee, Yoonjung; Kim, Minji

    2013-01-01

    This article describes the orthodontic treatment of a 25-year-old Korean female patient with anterior crowding, including palatally displaced lateral incisors. Her facial profile was satisfactory, but 3.5 mm of maxillary anterior crowding was observed. To correct this crowding, we decided to minimize the use of the conventional fixed orthodontic appliances and employed a less bulky and more aesthetic appliance for applying light continuous force. We determined the final positions of the maxillary teeth via a working model for diagnostic set up and achieved space gaining and alignment with simple Ni-Ti spring and stainless steel round tubes. Tooth alignment was achieved efficiently and aesthetically without the conventional brackets. PMID:24015390

  3. Angle Class I malocclusion treated with lower incisor extraction.

    PubMed

    Barbosa, Vanessa Leal Tavares

    2013-01-01

    In planning orthodontic cases that include extractions as an alternative to solve the problem of negative space discrepancy, the critical decision is to determine which teeth will be extracted. Several aspects must be considered, such as periodontal health, orthodontic mechanics, functional and esthetic alterations, and treatment stability. Despite controversies, extraction of teeth to solve dental crowding is a therapy that has been used for decades. Premolar extractions are the most common, but there are situations in which atypical extractions facilitate mechanics, preserve periodontal health and favor maintenance of the facial profile, which tends to unfavorably change due to facial changes with age. The extraction of a lower incisor, in selected cases, is an effective approach, and literature describes greater post-treatment stability when compared with premolar extractions. This article reports the clinical case of a patient with Angle Class I malocclusion and upper and lower anterior crowding, a balanced face and harmonious facial profile. The presence of gingival and bone recession limited large orthodontic movements. The molars and premolars were well occluded, and the discrepancy was mainly concentrated in the anterior region of the lower dental arch. The extraction of a lower incisor in the most ectopic position and with compromised periodontium, associated with interproximal stripping in the upper and lower arches, was the alternative of choice for this treatment, which restored function, providing improved periodontal health, maintained facial esthetics and allowed finishing with a stable and balanced occlusion. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO), as part of the requirements for obtaining the BBO Diplomate title. PMID:24094026

  4. Lower incisor intrusion with intraoral transosseous stainless steel wire anchorage in rabbits.

    PubMed

    Wu, Jian-chao; Huang, Ji-na; Lin, Xin-ping

    2010-06-01

    The purpose of this research was to investigate the potential use of intraoral transosseous stainless steel wires as anchorage for intrusion of the lower incisors using a rabbit model. Placement of intraoral transosseous stainless steel wires around incisors is similar to that of intraoral transosseous wiring of edentulous mandibular fractures. Ten male New Zealand rabbits, 9 +/- 1.5 months of age, average weight 1.8 +/- 0.3 kg, were used in this study. One lower incisor was intruded with a 50 g bilateral force using a coil spring for 10 weeks, while the other incisor served as the control. Clinical measurements of the distances between the occlusal edges of the incisors (EE) were performed weekly with a calliper. In addition to standard descriptive statistical calculations, a paired Student's t-test was used for comparison of the two groups. All surgical sites healed uneventfully after insertion of the wires. Significant differences were found in the change of EE between the experimental and control sides from 4 weeks onwards. Intrusion of the incisor, 4 +/- 0.58 mm, was seen on the test side, while EE on the control side remained unchanged. Within the limits of this animal study, it is concluded that the intraoral transosseous stainless steel wire anchorage system is a cost-effective method for intrusion of lower incisors when the use of other anchorage system is not possible. PMID:20034994

  5. Alternative treatment modalities for immature intruded permanent incisors: report of 2 cases.

    PubMed

    Gondim, Juliana Oliveira; Diniz, Michele Baffi; de Abreu-e-Lima, Fbio Cesar Braga; Pansani, Cyneu Aguiar; Moreira Neto, Jos Jeov Siebra

    2009-01-01

    Intrusion of permanent teeth is one of the most severe types of traumatic injuries. Different treatment strategies have been proposed, and the best approach for each case depends on the stage of root development, severity of the intrusive luxation, presence of alveolar fracture and number of intruded teeth. The purpose of this paper is to describe the treatment management of 2 cases of severely intruded immature permanent maxillary central incisors in 7 1/2- and 8-year-old children. In case 1, the traumatized tooth was treated by surgical repositioning, while in case 2 watchful waiting for spontaneous re-eruption was the treatment of choice. Treatment strategies were successful in both cases, as demonstrated by the continuation of root development, maintenance of pulp vitality, and absence of signs of periapical pathosis during the follow-up period. Regardless of the treatment strategy traumatically intruded teeth should undergo periodical clinical and radiographic surveillance on a long-term basis to allow early detection of possible complications. PMID:19722445

  6. Extraction of an incisor embedded within the nasal cavity in two guinea pigs.

    PubMed

    Kido, Nobuhide; Ono, Kaori; Omiya, Tomoko; Oguchi, Yukio; Setogawa, Moemi; Machida, Yuuki

    2016-01-01

    Oral examination of two guinea pigs revealed that the unilateral incisor was absent. On radiographic examination, the incisor was identified within the nasal cavity in both patients. Under anesthesia in both patients, the skin was incised from the nostril to 1.5 cm proximal, and the premaxilla and part of the maxilla were exposed. The bone was removed using a surgical drill, and the incisor was exposed in the nasal cavity. The root was grasped with forceps and carefully extracted as it was degraded and very fragile. Diagnosis was easy using oral and radiographic examination. In guinea pig patients where an incisor is absent on oral examination, this condition should be considered. PMID:26118492

  7. Extraction of an incisor embedded within the nasal cavity in two guinea pigs

    PubMed Central

    KIDO, Nobuhide; ONO, Kaori; OMIYA, Tomoko; OGUCHI, Yukio; SETOGAWA, Moemi; MACHIDA, Yuuki

    2015-01-01

    Oral examination of two guinea pigs revealed that the unilateral incisor was absent. On radiographic examination, the incisor was identified within the nasal cavity in both patients. Under anesthesia in both patients, the skin was incised from the nostril to 1.5 cm proximal, and the premaxilla and part of the maxilla were exposed. The bone was removed using a surgical drill, and the incisor was exposed in the nasal cavity. The root was grasped with forceps and carefully extracted as it was degraded and very fragile. Diagnosis was easy using oral and radiographic examination. In guinea pig patients where an incisor is absent on oral examination, this condition should be considered. PMID:26118492

  8. Excess NF-?B induces ectopic odontogenesis in embryonic incisor epithelium.

    PubMed

    Blackburn, J; Kawasaki, K; Porntaveetus, T; Kawasaki, M; Otsuka-Tanaka, Y; Miake, Y; Ota, M S; Watanabe, M; Hishinuma, M; Nomoto, T; Oommen, S; Ghafoor, S; Harada, F; Nozawa-Inoue, K; Maeda, T; Peterkov, R; Lesot, H; Inoue, J; Akiyama, T; Schmidt-Ullrich, R; Liu, B; Hu, Y; Page, A; Ramrez, ; Sharpe, P T; Ohazama, A

    2015-01-01

    Nuclear factor kappa B (NF-?B) signaling plays critical roles in many physiological and pathological processes, including regulating organogenesis. Down-regulation of NF-?B signaling during development results in hypohidrotic ectodermal dysplasia. The roles of NF-?B signaling in tooth development, however, are not fully understood. We examined mice overexpressing IKK?, an essential component of the NF-?B pathway, under keratin 5 promoter (K5-Ikk?). K5-Ikk? mice showed supernumerary incisors whose formation was accompanied by up-regulation of canonical Wnt signaling. Apoptosis that is normally observed in wild-type incisor epithelium was reduced in K5-Ikk? mice. The supernumerary incisors in K5-Ikk? mice were found to phenocopy extra incisors in mice with mutations of Wnt inhibitor, Wise. Excess NF-?B activity thus induces an ectopic odontogenesis program that is usually suppressed under physiological conditions. PMID:25376721

  9. A role for suppressed incisor cuspal morphogenesis in the evolution of mammalian heterodont dentition

    PubMed Central

    Ohazama, Atsushi; Blackburn, James; Porntaveetus, Thantrira; Ota, Masato S.; Choi, Hong Y.; Johnson, Eric B.; Myers, Philip; Oommen, Shelly; Eto, Kazuhiro; Kessler, John A.; Kondo, Takashi; Fraser, Gareth J.; Streelman, J. Todd; Pardiñas, Ulyses F. J.; Tucker, Abigail S.; Ortiz, Pablo E.; Charles, Cyril; Viriot, Laurent; Herz, Joachim; Sharpe, Paul T.

    2009-01-01

    Changes in tooth shape have played a major role in vertebrate evolution with modification of dentition allowing an organism to adapt to new feeding strategies. The current view is that molar teeth evolved from simple conical teeth, similar to canines, by progressive addition of extra “cones” to form progressively complex multicuspid crowns. Mammalian incisors, however, are neither conical nor multicuspid, and their evolution is unclear. We show that hypomorphic mutation of a cell surface receptor, Lrp4, which modulates multiple signaling pathways, produces incisors with grooved enamel surfaces that exhibit the same molecular characteristics as the tips of molar cusps. Mice with a null mutation of Lrp4 develop extra cusps on molars and have incisors that exhibit clear molar-like cusp and root morphologies. Molecular analysis identifies misregulation of Shh and Bmp signaling in the mutant incisors and suggests an uncoupling of the processes of tooth shape determination and morphogenesis. Incisors thus possess a developmentally suppressed, cuspid crown-like morphogenesis program similar to that in molars that is revealed by loss of Lrp4 activity. Several mammalian species naturally possess multicuspid incisors, suggesting that mammals have the capacity to form multicuspid teeth regardless of location in the oral jaw. Localized loss of enamel may thus have been an intermediary step in the evolution of cusps, both of which use Lrp4-mediated signaling. PMID:20018657

  10. Surgical Treatment of an Immature Short-Rooted Traumatized Incisor with an Extensive Apical Lesion Using CEM Cement

    PubMed Central

    Asgary, Saeed; Fazlyab, Mahta

    2015-01-01

    Severe traumatic injuries to immature teeth often cause damage to periodontal ligament as well as dental pulp; pulp necrosis, root resorption and subsequent apical lesion are common consequences. This article reports the surgical management of an infected immature maxillary central incisor associated with a gigantic periradicular lesion and severe root resorption. The tooth had a history of trauma and the patient suffered from purulent sinus tract and tooth mobility. After unsuccessful multi-session disinfection with calcium hydroxide, root end surgery was planned. During flap surgery and lesion enucleation, the root end was cleaned and filled with calcium-enriched mixture (CEM) cement. After one year, the radiographic examination revealed that the lesion was almost completely replaced with newly formed bone. In addition, clinical examination showed favorable outcomes; the tooth was symptom-free and in function. Due to chemical, physical and biological properties of CEM cement, this biomaterial might be considered as the root-end filling material of choice. PMID:25834603

  11. Inhibition of Notch Signaling During Mouse Incisor Renewal Leads to Enamel Defects.

    PubMed

    Jheon, Andrew H; Prochazkova, Michaela; Meng, Bo; Wen, Timothy; Lim, Young-Jun; Naveau, Adrien; Espinoza, Ruben; Cox, Timothy C; Sone, Eli D; Ganss, Bernhard; Siebel, Christian W; Klein, Ophir D

    2016-01-01

    The continuously growing rodent incisor is an emerging model for the study of renewal of mineralized tissues by adult stem cells. Although the Bmp, Fgf, Shh, and Wnt pathways have been studied in this organ previously, relatively little is known about the role of Notch signaling during incisor renewal. Notch signaling components are expressed in enamel-forming ameloblasts and the underlying stratum intermedium (SI), which suggested distinct roles in incisor renewal and enamel mineralization. Here, we injected adult mice with inhibitory antibodies against several components of the Notch pathway. This blockade led to defects in the interaction between ameloblasts and the SI cells, which ultimately affected enamel formation. Furthermore, Notch signaling inhibition led to the downregulation of desmosome-specific proteins such as PERP and desmoplakin, consistent with the importance of desmosomes in the integrity of ameloblast-SI attachment and enamel formation. Together, our data demonstrate that Notch signaling is critical for proper enamel formation during incisor renewal, in part by regulating desmosome-specific components, and that the mouse incisor provides a model system to dissect Jag-Notch signaling mechanisms in the context of mineralized tissue renewal. 2015 American Society for Bone and Mineral Research. PMID:26179131

  12. The Effect of Changes in Lower Incisor Inclination on Gingival Recession

    PubMed Central

    Kamak, Gulen; Kamak, Hasan; Keklik, Hakan; Gurel, Hakan Gurcan

    2015-01-01

    Aim. Orthodontic treatment may promote development of recessions. The mechanism by which orthodontic treatment influences occurrence of recessions remains unclear. The aim of this study was to test the hypothesis that a change of mandibular incisor inclination promotes development of labial gingival recessions. Materials and Methods. The study sample comprised dental casts and lateral cephalograms obtained from 109 subjects before orthodontic treatment (Tb) and after orthodontic treatment (Ta). Depending on the change of lower incisor inclination during treatment, the subjects were divided into three groups: Retroclination (R), Stable Position (S), and Proclination (P). The presence of gingival recessions of mandibular incisors and clinical crown heights were assessed on plaster models. Results and Conclusions. From Tb to Ta, Inc_Incl showed a statistically significant change in the R, P, and S groups (p < 0.05). Increase of clinical crown heights of the lower incisors (42, 4, and 31) was not statistically significant in any group. The only statistically significant intergroup difference was the greater increase of the clinical crown height of tooth number 32 in the P group in comparison with the R group (p = 0.049). The change of lower incisor inclination during treatment did not lead to development of labial gingival recessions in the study sample. PMID:25961071

  13. IN VITRO INCIDENCE OF ROOT CANAL BIFURCATION IN MANDIBULAR INCISORS BY RADIOVISIOGRAPHY

    PubMed Central

    de Oliveira, Simone Helena Gonçalves; de Moraes, Luiz César; Faig-Leite, Horácio; Camargo, Samira Esteves Afonso; Camargo, Carlos Henrique Ribeiro

    2009-01-01

    Objective: The aim of this study was to verify, in vivo and in vitro, the prevalence of root canal bifurcation in mandibular incisors by digital radiography. Material and Methods: Four hundred teeth were analyzed for the in vivo study. Digital radiographs were taken in an orthoradial direction from the mandibular incisor and canine regions. The digital radiographs of the canine region allowed visualizing the incisors in a distoradial direction using 20° deviation. All individuals agreed to participate by signing an informed consent form. The in vitro study was conducted on 200 mandibular incisors positioned on a model, simulating the mandibular dental arch. Digital radiographs were taken from the mandibular incisors in both buccolingual and mesiodistal directions. Results: The digital radiography showed presence of bifurcation in 20% of teeth evaluated in vitro in the mesiodistal direction. In the buccolingual direction, 17.5% of teeth evaluated in vivo and 15% evaluated in vitro presented bifurcation or characteristics indicating bifurcation. Conclusions: Digital radiography associated with X-ray beam distally allowed detection of a larger number of cases of bifurcated root canals or characteristics of bifurcation. PMID:19466258

  14. Orthodontic treatment of a mandibular incisor fenestration resulting from a broken retainer.

    PubMed

    Farret, Marcel M; Farret, Milton M B; da Luz Vieira, Gustavo; Assaf, Jamal Hassan; de Lima, Eduardo Martinelli S

    2015-08-01

    This article describes the orthodontic relapse with mandibular incisor fenestration in a 36-year-old man who had undergone orthodontic treatment 21 years previously. The patient reported that his mandibular 3 × 3 bonded retainer had been partially debonded and broken 4 years earlier. The mandibular left lateral incisor remained bonded to the retainer and received the entire load of the incisors; consequently, there was extreme labial movement of the root, resulting in dental avulsion. As part of the treatment, the root was repositioned lingually using a titanium-molybdenum segmented archwire for 8 months, followed by endodontic treatment, an apicoectomy, and 4 months of alignment and leveling of both arches. The treatment outcomes were excellent, and the tooth remained stable, with good integrity of the mesial, distal, and lingual alveolar bones and periodontal ligament. The 1-year follow-up showed good stability of the results. PMID:26232842

  15. Alignment of transposed mandibular lateral incisor and canine using removable appliances.

    PubMed

    Canoglu, E; Kocadereli, I; Turgut, M D

    2009-09-01

    The purpose of this paper was to present the management of a rarely encountered transposition anomaly involving the mandibular permanent lateral incisor and the canine. In the literature, the treatment of this type of anomaly involves fixed orthodontic appliances. The treatment of the present case, however, was performed with removable appliances. Transposition of the permanent mandibular right lateral incisor and the permanent mandibular right canine was detected in a 12 year old girl. The primary mandibular right canine was extracted to enable the distal movement of the permanent lateral incisor by the eruption force of the permanent canine. The transposed teeth were then aligned in the arch by using removable appliances. The forms of the teeth were changed with each other with composite restorations. PMID:19709117

  16. Interdisciplinary treatment of an end-to-end occlusion due to congenitally missing maxillary lateral incisors.

    PubMed

    Sesemann, Michael R; Patrick, Bradford

    2010-01-01

    Odontogenic aplasia, or the congenital absence of permanent teeth, is relatively common. When the missing teeth include the maxillary lateral incisors, treatment considerations must reconcile both esthetic and functional objectives. In developing dentition, erupting adjacent teeth can drift from their intended positions into the edentulous space created by the congenitally missing tooth. When this movement happens (e.g., cuspids shifting more mesially than normal), esthetic and functional problems occur. A restorative solution for missing maxillary lateral incisors subsequent to the loss of the maxillary incisor spaces is presented while highlighting the use of a leucite-reinforced material. This approach allowed for a minimal preparation design and conservation of tooth structure, providing an optimal bond. PMID:20712109

  17. Central neurocytoma: Management recommendations based on a 35-year experience

    SciTech Connect

    Leenstra, James L.; Rodriguez, Fausto J.; Frechette, Christina M.; Giannini, Caterina; Stafford, Scott L.; Pollock, Bruce E.; Schild, Steven E.; Scheithauer, Bernd W.; Jenkins, Robert B.; Buckner, Jan C.; Brown, Paul D.

    2007-03-15

    Purpose: To examine the outcomes of patients with histologically confirmed central neurocytomas. Methods and Materials: The data from 45 patients with central neurocytomas diagnosed between 1971 and 2003 were retrospectively evaluated. Various combinations of surgery, radiotherapy (RT), and chemotherapy had been used for treatment. Results: The median follow-up was 10.0 years. The 10-year overall survival and local control rate was 83% and 60%, respectively. Patients whose tumor had a mitotic index of <3 (per 10 high-power fields) experienced a 10-year survival and local control rate of 89% and 74%, respectively, compared with 57% (p = 0.040) and 46% (p = 0.14) for patients with a tumor mitotic index of {>=}3. The 10-year survival and local control rate was 90% and 74% for patients with typical tumors compared with 63% (p = 0.055) and 46% (p = 0.41) for those with atypical tumors. A comparison of gross total resection with subtotal resection showed no significant difference in survival or local control. Postoperative RT improved local control at 10 years (75% with RT vs. 51% without RT, p = 0.045); however, this did not translate into a survival benefit. No 1p19q deletions were found in the 19 tumors tested. Conclusion: Although the overall prognosis is quite favorable, one-third of patients experienced tumor recurrence or progression at 10 years, regardless of the extent of the initial resection. Postoperative RT significantly improved local control but not survival, most likely because of the effectiveness of salvage RT. For incompletely resected atypical tumors and/or those with a high mitotic index, consideration should be given to adjuvant RT because of the more aggressive nature.

  18. Spectrophotometric color evaluation of permanent incisors, canines and molars. A cross-sectional clinical study

    PubMed Central

    POP-CIUTRILA, IOANA-SOFIA; COLOSI, HORATIU ALEXANDRU; DUDEA, DIANA; BADEA, MANDRA EUGENIA

    2015-01-01

    Background and aims An accurate color reproduction represents the final validation level of an esthetic anterior or posterior restoration. The aim of this study was to evaluate the color of permanent maxillary incisors, canines and molars, using a clinical spectrophotometer. Methods The Vita Easyshade Advance 4.0® intraoral spectrophotometer was used by one clinician to determine the color of 369 permanent maxillary incisors, canines and molars. The best matches to Vitapan Classical® and 3D-Master® shade guides were recorded. A one-way analysis of variance and Kruskal-Wallis test were used to compare L*, a*, b*, c* and h* color coordinates among the 3 types of teeth. Differences between the mean values of all color coordinates were evaluated by use of Bonferroni corrections. Color difference (ΔE*) between incisors, canines and molars was calculated from ΔL*, Δa* and Δb* data and the results were compared to ΔE*=3.3 acceptability threshold. Results Except for Δa* and Δh* between canines and molars, statistically significant differences among the mean differences of all color coordinates were found when the 3 types of teeth were compared by pairs. The most frequently measured shades were A1 (48.4%), respectively 1M1 (31.5%) for incisors, B3 (36.6%), respectively 2M3 (39.8%) for canines and B3 (44.7%), respectively 2M3 (52%) for molars. Incisors had the highest lightness values, followed by canines and molars. Molars were the most chromatic with the highest a* and b* values. Conclusions Despite the limitations of this study, color differences among incisors, canines and molars were found to be statistically significant, above the clinical acceptability threshold established. In conclusion, successful esthetic restorations of permanent teeth of the same patient need an individual color assessment and reproduction of every type of tooth. PMID:26733753

  19. Static Thrust of an Annular Nozzle with a Concave Central Base

    NASA Technical Reports Server (NTRS)

    Corson, Blake W., Jr.; Mercer, Charles E.

    1960-01-01

    A static test of an annular nozzle with a concave central base, producing a jet in which tangents to the jet streamlines at the exit converged toward a region on the axis of symmetry downstream of the exit, has indicated good thrust performance. A value of nozzle-flow coefficient only slightly less than unity indicates the internal loss to be small. Pressures on the concave central base are relatively large and positive, and a predictable portion of the total thrust of the jet is exerted on the central base.

  20. Treating dental crowding with mandibular incisor extraction in an Angle Class I patient.

    PubMed

    Machado, Gislana Braga

    2015-01-01

    Mandibular dental crowding often encourages patients to seek orthodontic treatment. The orthodontist should decide between protrusion of incisors or decrease in dental volume so as to achieve proper alignment and leveling. The present study reports the treatment of an Angle Class I malocclusion adolescent female brachyfacial patient with severe mandibular dental crowding, increased curve of Spee and deep overbite. The patient was treated with extraction of a mandibular incisor. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:26154463

  1. Orthodontic treatment of unilateral cleft lip and alveolus patient with maxillary lateral incisor missing: case report.

    PubMed

    Pisek, Poonsak; Manosudprasit, Montian; Wangsrimongkol, Tasanee; Pasasuk, Apaporn; Somsuk, Thanatpiya

    2013-09-01

    The esthetics of a patient with a cleft lip and alveolus and missing maxillary lateral incisor is important. A girl, aged 9 years 3 months with repaired left unilateral cleft of primary palate only was referred for orthodontic evaluation of her anterior tooth-crowding. She was unhappy with the unattractive appearance of her maxillary anterior teeth, which were behind her mandibular anterior teeth. Alveolar bone grafting along with canine substitution to replace her missing lateral incisor were recommended for this patient. The post-treatment results were excellent with good occlusion, acceptable profile, and remained stable one year after conclusion of active treatment. PMID:24386758

  2. Agenesis of Maxillary Lateral Incisors: Treatment Involves Much More Than Just Canine Guidance

    PubMed Central

    Silveira, Giordani Santos; Mucha, José Nelson

    2016-01-01

    Objective: In this study, we aimed highlight some clinical features present in patients whose maxillary lateral incisors are missing, and proposed more logical, rational and predictable solutions to inform decision making in rehabilitation procedures. Methods: Literature review and discussion. Conclusion: Choosing the best possible treatment for congenital absence of maxillary lateral incisors depends on the multidisciplinary diagnosis of facial, occlusal, functional and periodontal features. It also depends on the individual long-term stability, and it does not only rely on canine-guided disocclusion. PMID:27006720

  3. Treating dental crowding with mandibular incisor extraction in an Angle Class I patient

    PubMed Central

    Machado, Gislana Braga

    2015-01-01

    Mandibular dental crowding often encourages patients to seek orthodontic treatment. The orthodontist should decide between protrusion of incisors or decrease in dental volume so as to achieve proper alignment and leveling. The present study reports the treatment of an Angle Class I malocclusion adolescent female brachyfacial patient with severe mandibular dental crowding, increased curve of Spee and deep overbite. The patient was treated with extraction of a mandibular incisor. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:26154463

  4. Bilateral Supernumerary Deciduous Maxillary Lateral Incisors with Fusion: Report of a Rare Case.

    PubMed

    Ghaderi, Faezeh; Rafiee, Azade

    2016-03-01

    Dental anomaly in number, size and shape might be due to excessive activation of dental lamina during the morpho-differentiation stage. Fusion is one of the most unusual and rare anomalies of shape of the teeth. It frequently involves the supernumerary teeth resulting in a challenging differential diagnosis with gemination. Dental anomalies may result in different problems such as delayed eruption and crowding; thus, early diagnosis is required for effective intervention and proper in-time treatment. The case reported here is a 4-year-old girl with bilateral supernumerary primary maxillary lateral incisors associated with fusion between primary maxillary left lateral incisor and supernumerary lateral tooth. PMID:26966712

  5. Bilateral Supernumerary Deciduous Maxillary Lateral Incisors with Fusion: Report of a Rare Case

    PubMed Central

    Ghaderi, Faezeh; Rafiee, Azade

    2016-01-01

    Dental anomaly in number, size and shape might be due to excessive activation of dental lamina during the morpho-differentiation stage. Fusion is one of the most unusual and rare anomalies of shape of the teeth. It frequently involves the supernumerary teeth resulting in a challenging differential diagnosis with gemination. Dental anomalies may result in different problems such as delayed eruption and crowding; thus, early diagnosis is required for effective intervention and proper in-time treatment. The case reported here is a 4-year-old girl with bilateral supernumerary primary maxillary lateral incisors associated with fusion between primary maxillary left lateral incisor and supernumerary lateral tooth. PMID:26966712

  6. An Agent-Based Model of Centralized Institutions, Social Network Technology, and Revolution

    PubMed Central

    Makowsky, Michael D.; Rubin, Jared

    2013-01-01

    This paper sheds light on the general mechanisms underlying large-scale social and institutional change. We employ an agent-based model to test the impact of authority centralization and social network technology on preference falsification and institutional change. We find that preference falsification is increasing with centralization and decreasing with social network range. This leads to greater cascades of preference revelation and thus more institutional change in highly centralized societies and this effect is exacerbated at greater social network ranges. An empirical analysis confirms the connections that we find between institutional centralization, social radius, preference falsification, and institutional change. PMID:24278280

  7. Ground-based Fourier transform infrared spectroscopy in central Mexico

    NASA Astrophysics Data System (ADS)

    Plaza, Eddy; Stremme, Wolfgang; Bezanilla, Alejandro; Baylon, Jorge; Grutter, Michel; Blumenstock, Thomas; Hase, Frank

    2014-05-01

    Altzomoni is a high altitude station in central Mexico (19.12 N, 98.65 W, 4000 m a.s.l.) for continuous measurements of various atmospheric parameters. It is located within the Izta-Popo National Park and is operated remotely from the UNAM campus. Since May 2012, high resolution solar absorption spectra have been recorded from this site using a FTIR from Bruker (HR120/5) equipped with MCT, InSb and InGaAs detectors and various optical filters. In this contribution we present a detailed description of the measurement site and the instrumental set-up including a record of the instrumental line-shapes (modulation efficiency and phase error) obtained from cell measurements and analyzed with the LINEFIT code. A preliminary analysis of almost two years of spectra recorded at the Altzomoni site resulting in profile retrievals of four NDACC gases O3, CO, HF and HCl is presented. The retrieval code PROFFIT is used and the Averaging Kernels and an error analysis are used to describe the quality of the measurements. The annual cycles in the time series of O3 and CO are presented and discussed, as well as some examples of anomalies due to volcanic gas emissions of HF and HCl are shown. The presented work is part of an effort to certify this station as part of the NDACC international network.

  8. Chytridiomycosis risk among Central European amphibians based on surveillance data.

    PubMed

    Bal, Vojtech; Vojar, Jir?; Civi, Petr; Andera, Martin; Roznek, Roman

    2014-11-13

    The Czech Republic hosts a surprisingly rich biodiversity of amphibians representing the majority of amphibian species present in all of Central and Eastern Europe. Surveillance data of Batrachochytrium dendrobatidis (Bd) collected during 2008 to 2012 were analysed for basic patterns of prevalence and infection intensity among species, age groups and localities. In addition, an investigation was made into possible data bias due to varying PCR inhibition. Infection prevalence in the genus Pelophylax was significantly higher than in other sampled taxa, while Bombina and Bufo were infected with intermediate prevalence. Individual mortalities putatively caused by chytridiomycosis were detected in Bombina and Bufo, but not in Pelophylax. Differences among localities were seen to modulate the pathogen's infection rate and influence overall individual infection intensities. PCR inhibition occurred significantly more often in samples from the genus Pelophylax than in other tested taxa (Bufo bufo, B. viridis, Bombina bombina, Pelobates fuscus and Rana dalmatina). Although we found no completely inhibited samples within the genus Bombina, the infection loads were lower in the sample set processed without bovine serum albumin, suggesting some level of PCR inhibition. The combination of high Bd prevalence with no apparent deleterious effect and the high dispersal abilities of water frogs predispose them to act as vectors for chytridiomycosis. It is possible that the role of Pelophylax frogs in the spread of Bd is overlooked due to a large proportion of unrecognized false negatives, but this issue needs further confirmation. PMID:25392037

  9. Autotransplantation of a Supernumerary Tooth to Replace a Misaligned Incisor with Abnormal Dimensions and Morphology: 2-Year Follow-Up

    PubMed Central

    Tirali, R. Ebru; Sar, Cagla; Ates, Ufuk; Kizilkaya, Metin; Cehreli, S. Burcak

    2013-01-01

    Autotransplantation is a viable treatment option to restore esthetics and function impaired by abnormally shaped teeth when a suitable donors tooth is available. This paper describes the autotransplantation and 2-year follow-up of a supernumerary maxillary incisor as a replacement to a misaligned maxillary incisor with abnormal crown morphology and size. The supernumerary incisor was immediately autotransplanted into the extraction site of the large incisor and was stabilized with a bonded semirigid splint for 2 weeks. Fixed orthodontic therapy was initiated 3 months after autotransplantation. Ideal alignment of the incisors was accomplished after 6 months along with radiographic evidence of apical closure and osseous/periodontal regeneration. In autogenous tooth transplantation, a successful clinical outcome can be achieved if the cases are selected and treated properly. PMID:23476813

  10. Biofilm-based central line-associated bloodstream infections.

    PubMed

    Yousif, Ammar; Jamal, Mohamed A; Raad, Issam

    2015-01-01

    Different types of central venous catheters (CVCs) have been used in clinical practice to improve the quality of life of chronically and critically ill patients. Unfortunately, indwelling devices are usually associated with microbial biofilms and eventually lead to catheter-related bloodstream infections (CLABSIs).An estimated 250,000-400,000 CLABSIs occur every year in the United States, at a rate of 1.5 per 1,000 CVC days and a mortality rate of 12-25 %. The annual cost of caring for patients with CLABSIs ranges from 296 million to 2.3 billion dollars.Biofilm formation occurs on biotic and abiotic surfaces in the clinical setting. Extensive studies have been conducted to understand biofilm formation, including different biofilm developmental stages, biofilm matrix compositions, quorum-sensing regulated biofilm formation, biofilm dispersal (and its clinical implications), and multi-species biofilms that are relevant to polymicrobial infections.When microbes form a matured biofilm within human hosts through medical devices such as CVCs, the infection becomes resistant to antibiotic treatment and can develop into a chronic condition. For that reason, many techniques have been used to prevent the formation of biofilm by targeting different stages of biofilm maturation. Other methods have been used to diagnose and treat established cases of CLABSI.Catheter removal is the conventional management of catheter associated bacteremia; however, the procedure itself carries a relatively high risk of mechanical complications. Salvaging the catheter can help to minimize these complications.In this article, we provide an overview of microbial biofilm formation; describe the involvement of various genetic determinants, adhesion proteins, organelles, mechanism(s) of biofilm formation, polymicrobial infections, and biofilm-associated infections on indwelling intravascular catheters; and describe the diagnosis, management, and prevention of catheter-related bloodstream infections. PMID:25366227

  11. Transoral robotic surgery of the central skull base: preclinical investigations.

    PubMed

    Fernandez-Nogueras, F J J; Katati, M J; Arraez Sanchez, M A; Molina Martinez, M; Sanchez Carrion, M

    2014-06-01

    In this study we explored possible applications of the da Vinci system in approaching the skull base at optic chiasm level on two cryopreserved cadavers, using an entirely transoral robotic technique (TORS). We used a standard 12 mm endoscopy and 8 mm terminals. Bone drilling was performed manually. The da Vinci system is equipped with very good illumination and 3D viewing, thus providing excellent vision and great maneuverability even in the less accessible areas of the skull. Our experience demonstrates that an entirely transoral skull base robotic approach to this complex anatomical region has many advantages as compared to traditional techniques. PMID:24077869

  12. Endodontic Treatment and Esthetic Management of a Geminated Central Incisor Bearing a Talon Cusp

    PubMed Central

    Tar?m Erta?, Elif; Y?rcal? At?c?, Meral; Arslan, Hakan; Ya?a, Bilal; Erta?, Hseyin

    2014-01-01

    Gemination with talon cusps is an uncommon morphologic dental anomaly, characterized by the formation of clinically wide tooth that can cause significant aesthetic and clinical problems including esthetic impairment, pain, caries susceptibility, and tooth crowding. These morphological dental anomalies have specific treatment needs due to the abnormal morphology and need virtuous radiologic diagnosis. Multidisciplinary approach can supply success of the treatment plan that can provide esthetic and occlusal requirements. In this case report, the multidisciplinary approach for the treatment of geminated tooth with talon cusp is presented with the clinical and radiographic findings. PMID:24715989

  13. Central Line-Associated Bloodstream Infection Prevention: Standardizing Practice Focused on Evidence-Based Guidelines.

    PubMed

    Conley, Susanne B

    2016-02-01

    Central venous access devices (CVADs) are integral to the treatment and provision of supportive care for many patients with cancer. Central venous catheters are the most frequent cause of healthcare-associated bloodstream infections. Healthcare-associated bloodstream infections can be prevented when evidence-based practices are followed consistently over time. Establishing nursing best practice with CVADs in the ambulatory setting presents additional challenges because of multiple providers, caregivers, and policies. This article identifies evidence-based practice strategies implemented at a comprehensive ambulatory cancer center to standardize best nursing practice for central lines.?. PMID:26800401

  14. Mandibular Symphyseal/Parasymphyseal Fracture with Incisor Tooth Loss: Preventing Lower Arch Constriction.

    PubMed

    Rahpeyma, Amin; Khajehahmadi, Saeedeh; Abdollahpour, Somayeh

    2016-03-01

    Mandibular fractures are the second most common fractures of the face after the nasal bone. Mandibular symphyseal/parasymphyseal fracture comprises 15.6 to 29.3% of mandibular fractures. Tooth loss in the fracture line is a known phenomenon, but space loss has not been evaluated comprehensively in the literature. In a retrospective study, patients with mandibular symphyseal/parasymphyseal fractures, who had been treated from 2012 to 2013 in Mashhad University, Iran, Emdadi Hospital, were recalled. Patients with mandibular incisor tooth/teeth loss were included in the study. Space loss, the technique used to replace the lost tooth/teeth, upper and lower dental midline relationship, combination fracture or fractures in other facial skeleton, and type of treatment were evaluated. Of 98 patients with mandibular symphyseal/parasymphyseal fractures, 22.5% had incisor tooth/teeth loss. In this group, 73% had space loss. Only four patients had replaced the lost tooth/teeth. Dental midlines did not match each other in patients whose feature was evaluated. Open reduction and internal fixation with miniplates were used in symphyseal/parasymphyseal fractures except one. Space loss after mandibular symphyseal/parasymphyseal fracture with incisor tooth loss is a common error. The most important factor to prevent complications related to space loss following mandibular symphyseal/parasymphyseal fracture accompanying incisor tooth loss is space preservation. PMID:26889343

  15. Prosthetic and orthodontic rehabilitation of a patient with missing maxillary lateral incisors: a case report.

    PubMed

    Gür, Emel; Aykent, Filiz; Gelgör, Ibrahim Erhan

    2007-01-01

    IPS Empress 2 materials can be used for fabrication of short-span fixed partial dentures in the anterior region as well as single crowns. This clinical report describes the prosthodontic treatment of a 16-year-old male patient with missing permanent maxillary left and right incisors with IPS Empress 2 fixed partial dentures following orthodontic treatment. PMID:17508075

  16. Measurement of Incisor Overjet and Physiological Diastemata Parameters in Quarter Horse Foals.

    PubMed

    Omura, Carla Michel; Drumond, Bianca; Rossi, João Luiz Júnior; Coelho, Clarisse Simões; Gioso, Marco Antônio

    2015-01-01

    Cephalometric studies are important to quantify abnormalities of jaw length and positioning. In this study, 4 to 7-month-old Quarter horse foals (n = 51) were examined to determine overjet (horizontal overlap) prevalence and measure the size of the physiological diastemata. Results were analyzed in relation to age, sex, and lineage. Another aim of this study was to develop a simple field technique for measuring incisor malocclusion and physiological diastemata dimensions that could be used to monitor the growth of the rostral components of maxilla, incisive bone, and mandible. The overall prevalence of overjet lesions in these foals was 51%. Females were overrepresented (61.5%). Overjet occurred more commonly in show foals (50% prevalence) than other working (7.7%) and race (42.3%) lineage foals. Significant differences were found between maxillary and mandibular physiological diastemata lengths in foals of all ages and, as expected, there was a positive statistical correlation between age and maxillary and mandibular physiological diastemata measurements. Incisor overjet was present in 44.4% of 4-month-old foals, 45.5% of 5-month-old foals, 58.3% of 6-month-old foals, and 60% of 7-month-old foals. There was a weak positive correlation between age and the presence of incisor overjet. It was concluded that incisor overiet was common among Quarter horse foals, especially those from show and race lineages. The field technique for physiological diastema measurements was considered effective. PMID:26638296

  17. Botulinum neurotoxin type A in the masseter muscle: Effects on incisor eruption in rabbits

    PubMed Central

    Navarrete, Alfonso L.; Rafferty, Katherine L.; Liu, Zi Jun; Ye, Wenmin; Greenlee, Geoffrey M.; Herring, Susan W.

    2015-01-01

    Introduction Botulinum neurotoxins are responsible for the paralytic food poisoning, botulism. Commercial formulations such as botulinum neurotoxin type A are increasingly used for various conditions, including cosmetic recontouring of the lower face by injection of the large masseter muscles. The paralysis of a major muscle of mastication lowers occlusal force and thus might affect tooth eruption. The purpose of this study was to investigate the effects of unilateral masseter muscle injection of botulinum neurotoxin type A on the rate of eruption of incisors in a rabbit model. We hypothesized that the teeth would overerupt in an underloaded environment. Methods Forty rabbits were injected with either botulinum neurotoxin type A or saline solution in 1 masseter muscle. Mastication and muscle force production were monitored, and incisor eruption rate was assessed by caliper measurement of grooved teeth. Results The injection of saline solution had no effect. The masseter muscle injected with botulinum neurotoxin type A showed a dramatic loss of force 3 weeks after injection despite apparently normal mastication. Incisor eruption rate was significantly decreased for the botulinum neurotoxin type A group, an effect attributed to decreased attrition. Conclusions This study has implications for orthodontics. Although findings from ever-growing rabbit incisors cannot be extrapolated to human teeth, it is clear that botulinum neurotoxin type A caused a decrease in bite force that could influence dental eruption. PMID:23561411

  18. Organic and inorganic content of fluorotic rat incisors measured by FTIR spectroscopy

    NASA Astrophysics Data System (ADS)

    Porto, Isabel Maria; Saiani, Regina Aparecida; Chan, K. L. Andrew; Kazarian, Sergei G.; Gerlach, Raquel Fernanda; Bachmann, Luciano

    2010-09-01

    Details on how fluoride interferes in enamel mineralization are still controversial. Therefore, this study aimed at analyzing the organic contents of fluorosis-affected teeth using Fourier Transformation Infrared spectroscopy. To this end, 10 male Wistar rats were divided into two groups: one received 45 ppm fluoride in distilled water for 60 days; the other received distilled water only. Then, the lower incisors were removed and prepared for analysis by two FTIR techniques namely, transmission and micro-ATR. For the first technique, the enamel was powdered, whereas in the second case one fluorotic incisor was cut longitudinally for micro-ATR. Using transmission and powdered samples, FTIR showed a higher C-H content in the fluorotic enamel compared with control enamel ( p < 0.05, n = 4 in the flurotic, and n = 5 in the control group). Results from the micro-ATR-FTIR spectroscopic analysis on one longitudinally cut incisor carried out at six points reveal a higher C-H bond content at the surface of the enamel, with values decreasing toward the dentine-enamel junction, and reaching the lowest values at the subsuperficial enamel. These results agree with the morphological data, which indicate that in the rat incisor the fluorotic lesion is superficial, rather than subsuperficial, as in the case of human enamel. The results also suggest that the increased C-H bond content may extend toward the more basal enamel (intraosseous), indicating that fluorotic enamel may intrinsically contain more protein. Finally, particularly when coupled to ATR, FTIR is a suitable tool to study the rat incisor enamel, which is a largely used model of normal and abnormal amelogenesis. Further studies along this line may definitely answer some questions regarding protein content in fluorotic enamel as well as their origin.

  19. Caribbean and Central American Women's Feminist Inquiry through Theater-Based Action Research

    ERIC Educational Resources Information Center

    Snchez Ares, Roco

    2015-01-01

    Feminist action research interrogates gendered dynamics in the development of a collective consciousness. A group of immigrant Latina women (Latinas) from the Caribbean and Central America employed community-based theater as an instrument to mobilize diverse audiences against discriminatory practices and policies. Based on their theater work, I

  20. Caribbean and Central American Women's Feminist Inquiry through Theater-Based Action Research

    ERIC Educational Resources Information Center

    Sánchez Ares, Rocío

    2015-01-01

    Feminist action research interrogates gendered dynamics in the development of a collective consciousness. A group of immigrant Latina women (Latinas) from the Caribbean and Central America employed community-based theater as an instrument to mobilize diverse audiences against discriminatory practices and policies. Based on their theater work, I…

  1. Spatial drought reconstructions for central High Asia based on tree rings

    NASA Astrophysics Data System (ADS)

    Fang, Keyan; Davi, Nicole; Gou, Xiaohua; Chen, Fahu; Cook, Edward; Li, Jinbao; D'Arrigo, Rosanne

    2010-11-01

    Spatial reconstructions of drought for central High Asia based on a tree-ring network are presented. Drought patterns for central High Asia are classified into western and eastern modes of variability. Tree-ring based reconstructions of the Palmer drought severity index (PDSI) are presented for both the western central High Asia drought mode (1587-2005), and for the eastern central High Asia mode (1660-2005). Both reconstructions, generated using a principal component regression method, show an increased variability in recent decades. The wettest epoch for both reconstructions occurred from the 1940s to the 1950s. The most extreme reconstructed drought for western central High Asia was from the 1640s to the 1650s, coinciding with the collapse of the Chinese Ming Dynasty. The eastern central High Asia reconstruction has shown a distinct tendency towards drier conditions since the 1980s. Our spatial reconstructions agree well with previous reconstructions that fall within each mode, while there is no significant correlation between the two spatial reconstructions.

  2. Central venous blood gas and acid-base status in conscious dogs and cats.

    PubMed

    Tamura, Jun; Itami, Takaharu; Ishizuka, Tomohito; Fukui, Sho; Miyoshi, Kenjirou; Sano, Tadashi; Yamashita, Kazuto

    2015-07-01

    To determine the reference level of central venous oxygen saturation (ScvO2) and clinical efficacy of central venous blood gas analysis, partial pressures of oxygen and carbon dioxide, pH, oxygen saturation, base excess (B.E.) and HCO3 concentration were compared between simultaneously obtained central venous and arterial blood samples from conscious healthy 6 dogs and 5 cats. Comparisons between arteriovenous samples were performed by a paired t-test and Bland-Altman analysis. Between arteriovenous samples, B.E. showed good agreement, but there were significant differences in other parameters in the dogs, and no good agreement was detected in cats. The ScvO2 in dogs and cats were 82.3 3.5 and 62.4 13.5%, respectively. Central venous blood gas analysis is indispensable, especially in cats. PMID:25754649

  3. Zinc iodide-osmium tetroxide impregnation of the "tubulo-vesicular system" in Tomes' process of the rat incisor ameloblast.

    PubMed

    Uchida, T; Warshawsky, H

    1992-03-01

    Zinc iodide-osmium tetroxide (ZIO) is a nonspecific but selective impregnation method that visualizes a tubulo-vesicular system in cells. The detailed structure and three-dimensional distribution of this ZIO-impregnated system was studied in the Tomes' process of secretory ameloblasts in the rat incisor. The ZIO-impregnated system consisted of an extensive array of smooth membrane-bound thick and thin tubules and vesicles. The interconnected thick and thin tubules formed a complex "core network" in the central cytoplasm of Tomes' process that enmeshed and often surrounded individual secretory granules. From the core network, radial branches extended toward the smooth cell membrane of the interdigitating portion of Tomes' process. Although the core network and branches frequently appeared connected to the secretory granules and the cell membrane, stereo-pair electron microscopy failed to show conclusive evidence of such continuity. However, many coated vesiclelike structures were attached to the core network and its branches. No special relationship was found between interrod and rod secretory sites and the tubulo-vesicular network. In thick sections, the ZIO-impregnated tubulo-vesicular network occupied a considerable volume of cytoplasm. The vinblastine-labile nature of this network as demonstrated previously (Nanci et al., 1987) indicated that the system undergoes rapid and extensive turnover. Considering the dynamic nature and sheer volume of the tubulo-vesicular system, we propose that it be regarded as a major cell organelle. PMID:1371907

  4. An investigation into the measurement of the working length of immature incisor teeth requiring endodontic treatment in children.

    PubMed

    Baggett, F J; Mackie, I C; Worthington, H V

    1996-08-10

    A study was undertaken to determine if a tactile technique, using absorbent paper points, could be used to estimate the working length of nonvital immature incisor teeth undergoing endodontic treatment. Two operators were involved in measuring 35 incisor teeth. The tactile technique was found to be valid and reliable. In 95% of the cases the estimated working length was within 1 mm of the radiographic diagnostic length. It is recommended that diagnostic radiographs are no longer necessary in the majority of cases involving endodontic treatment of incisor teeth requiring root end closure in children, for practitioners who are regularly carrying out endodontic treatment of immature incisor teeth. However, if a tooth has been on open drainage a diagnostic radiograph is still required. PMID:8810108

  5. Essentiality of Early Diagnosis of Molar Incisor Hypomineralization in Children and Review of its Clinical Presentation, Etiology and Management

    PubMed Central

    Jain, Abhay Kumar; Saha, Sonali; Singh, Jaspal

    2012-01-01

    Abstract Molar incisor hypomineralization (MIH) is a common developmental condition resulting in enamel defects in first permanent molars and permanent incisors. It presents at eruption of these teeth. One to four molars, and often also the incisors, could be affected. Since first recognized, the condition has been puzzling and interpreted as a distinct phenomenon unlike other enamel disturbances. Early diagnosis is essential since, rapid breakdown of tooth structure may occur, giving rise to acute symptoms and complicated treatment. The purpose of this article is to review MIH and illustrate its diagnosis and clinical management in young children. How to cite this article: Garg N, Jain AK, Saha S, Singh J. Essentiality of Early Diagnosis of Molar Incisor Hypomineralization in Children and Review of its Clinical Presentation, Etiology and Management. Int J Clin Pediatr Dent 2012;5(3):190-196. PMID:25206166

  6. Unilateral Fusion of Maxillary Lateral Incisor: Diagnosis Using Cone Beam Computed Tomography

    PubMed Central

    Castro, Iury Oliveira; Estrela, Carlos; Souza, Vincius Rezende; Lopes, Lawrence Gonzaga; de Souza, Joo Batista

    2014-01-01

    Objective. The objective of this paper is to report a dental fusion case focusing on clinical and radiographic features for the diagnosis. Method. To report a case of right maxillary lateral incisor fusion and a supernumerary tooth, the anatomy of the root canal and dental united portion were assessed by cone beam computed tomography (CBCT). Results. The clinical examination showed dental juxtaposition with the absence of interdental papilla and esthetic impairment in the right maxillary lateral incisor region. The periapical radiography did not provide enough information for the differential diagnosis due to the inherent limitations of this technique. CBCT confirmed the presence of tooth fusion. Conclusion. CBCT examination supports the diagnosis and provides both the identification of changes in tooth development and the visualization of their extent and limits. PMID:25587463

  7. Ageing horses by an examination of their incisor teeth: an (im)possible task?

    PubMed

    Muylle, S; Simoens, P; Lauwers, H

    1996-03-30

    It is generally considered that the age of a horse can be determined by examining its incisor teeth. However, the criteria used to determine age from dental configurations differ widely. The existence of this variety of rules and guidelines was the challenge for the present examination. Detailed descriptions of the incisor teeth of 212 horses of registered age were recorded and the results were compared with the age criteria of various authors. The time at which teeth were shed and the appearance of dental stars seemed to be more reliable features than the disappearance of the cups. The disappearance of the marks occurred four years later than usually stated. Other criteria, such as the presence of the seven-year notch and Galvayne's groove, were too variable and inconsistent to be reliable for the determination of age. PMID:8730689

  8. Sema3A chemorepellant regulates the timing and patterning of dental nerves during development of incisor tooth germ.

    PubMed

    Shrestha, Anjana; Moe, Kyaw; Luukko, Keijo; Taniguchi, Masahiko; Kettunen, Paivi

    2014-07-01

    Semaphorin 3A (Sema3A) axon repellant serves multiple developmental functions. Sema3A mRNAs are expressed in epithelial and mesenchymal components of the developing incisor in a dynamic manner. Here, we investigate the functions of Sema3A during development of incisors using Sema3A-deficient mice. We analyze histomorphogenesis and innervation of mandibular incisors using immunohistochemistry as well as computed tomography and thick tissue confocal imaging. Whereas no apparent disturbances in histomorphogenesis or hard tissue formation of Sema3A (-/-) incisors were observed, nerve fibers were prematurely seen in the presumptive dental mesenchyme of the bud stage Sema3A (-/-) tooth germ. Later, nerves were ectopically present in the Sema3A (-/-) dental papilla mesenchyme during the cap and bell stages, whereas in the Sema3A (+/+) mice the first nerve fibers were seen in the pulp after the onset of dental hard tissue formation. However, no apparent topographic differences in innervation pattern or nerve fasciculation were seen inside the pulp between postnatal and adult Sema3A (+/+) or Sema3A (-/-) incisors. In contrast, an abnormally large number of nerves and arborizations were observed in the Sema3A (-/-) developing dental follicle target field and periodontium and, unlike in the wild-type mice, nerve fibers were abundant in the labial periodontium. Of note, the observed defects appeared to be mostly corrected in the adult incisors. The expressions of Ngf and Gdnf neurotrophins and their receptors were not altered in the Sema3A (-/-) postnatal incisor or trigeminal ganglion, respectively. Thus, Sema3A is an essential, locally produced chemorepellant, which by creating mesenchymal exclusion areas, regulates the timing and patterning of the dental nerves during the development of incisor tooth germ. PMID:24752460

  9. Alveolar bone loss around incisors in Class I bidentoalveolar protrusion patients: a retrospective three-dimensional cone beam CT study

    PubMed Central

    Nahm, K-Y; Kang, J-H; Moon, S-C; Choi, Y-S; Kook, Y-A; Kim, S-H; Huang, JC

    2012-01-01

    Objectives The aim of this study was to test the null hypothesis that there is no difference in the alveolar bone thickness, bone loss or incidence of fenestrations between upper and lower incisors in skeletal Class I bidentoalveolar protrusive patients before orthodontic treatment. Methods Three-dimensional (3D) cone beam CT (CBCT) images were taken of 24 patients from the Republic of Korea (17 females and 7 males). Reformatted CBCT images were used to measure labial and lingual alveolar bone thickness (ABT) of the 4 upper incisors and 4 lower incisors of the 24 patients (total n = 192 incisors) at every 1/10 of root length (Level 0, cementoenamel junction (CEJ) area; Level 10, root apex area) as well as alveolar bone area (ABA) and alveolar bone loss (%BL) rate to dental root length. The numbers of fenestration teeth were also tallied. Results All anterior teeth were supported by <1 mm of ABT on the labial surfaces up to root length Level 8. ABA was statistically greater on the lingual aspect than the labial aspect in lower incisors. The %BL was 26.98% in the lower labial region, 19.27% in upper labial aspect and most severe on the lower lingual plate 31.25% compared with the labial plate. There were no significant differences in %BL between subgroups when categorized by sex or age. Fenestrations were 1.37 times more frequent on lower incisors (37) than upper incisors (27). Conclusion The null hypothesis was rejected, confirming that incisor periodontal support is poor and alveolar bone loss is severe even prior to the start of orthodontic treatment. Careful diagnosis using 3D CBCT images is needed to avoid iatrogenic degeneration of periodontal support around anterior teeth, particularly in the lower lingual bone plate region. PMID:22184474

  10. CentiServer: A Comprehensive Resource, Web-Based Application and R Package for Centrality Analysis

    PubMed Central

    Jalili, Mahdi; Salehzadeh-Yazdi, Ali; Asgari, Yazdan; Arab, Seyed Shahriar; Yaghmaie, Marjan; Ghavamzadeh, Ardeshir; Alimoghaddam, Kamran

    2015-01-01

    Various disciplines are trying to solve one of the most noteworthy queries and broadly used concepts in biology, essentiality. Centrality is a primary index and a promising method for identifying essential nodes, particularly in biological networks. The newly created CentiServer is a comprehensive online resource that provides over 110 definitions of different centrality indices, their computational methods, and algorithms in the form of an encyclopedia. In addition, CentiServer allows users to calculate 55 centralities with the help of an interactive web-based application tool and provides a numerical result as a comma separated value (csv) file format or a mapped graphical format as a graph modeling language (GML) file. The standalone version of this application has been developed in the form of an R package. The web-based application (CentiServer) and R package (centiserve) are freely available at http://www.centiserver.org/ PMID:26571275

  11. Treatment outcome and efficacy of an aligner technique regarding incisor torque, premolar derotation and molar distalization

    PubMed Central

    2014-01-01

    Background The aim of this study was to investigate the efficacy of orthodontic treatment using the Invisalign system. Particularly, we analyzed the influence of auxiliaries (Attachment/Power Ridge) as well as the staging (movement per aligner) on treatment efficacy. Methods We reviewed the tooth movements of 30 consecutive patients who required orthodontic treatment with Invisalign. In all patients, one of the following tooth movements was performed: (1) Incisor Torque >10, (2) Premolar derotation >10 (3) Molar distalization >1.5mm. The groups (1)-(3) were subdivided: in the first subgroup (a) the movements were supported with the use of an attachment, while in the subgroup (b) no auxiliaries were used (except incisor torque, in which Power Ridges were used). All tooth movements were performed in a split-mouth design. To analyze the clinical efficacy, pre-treatment and final plaster cast models were laser-scanned and the achieved tooth movement was determined by way of a surface/surface matching algorithm. The results were compared with the amount of tooth movement predicted by ClinCheck. Results The overall mean efficacy was 59% (SD?=?0.2). The mean accuracy for upper incisor torque was 42% (SD?=?0.2). Premolar derotation showed the lowest accuracy with approximately 40% (SD?=?0.3). Distalization of an upper molar was the most effective movement, with efficacy approximately 87% (SD?=?0.2). Conclusion Incisor torque, premolar derotation and molar distalization can be performed using Invisalign aligners. The staging (movement/aligner) and the total amount of planned movement have an significant impact on treatment efficacy. PMID:24923279

  12. Presurgical orthodontic decompensation alters alveolar bone condition around mandibular incisors in adults with skeletal Class III malocclusion

    PubMed Central

    Sun, Boyang; Tang, Jun; Xiao, Ping; Ding, Ying

    2015-01-01

    This study is to use cone beam computed tomography (CBCT) to acquire accurate radiographic images for alveolar bone in lower incisors and the change after presurgical orthodontic treatment. Seventeen patients with skeletal Class III malocclusion, ten normal occlusion subjects, and fifteen patients treated with orthodontic treatment and orthognathic surgery were included. CBCT images were obtained. The labial and lingual inclinations of mandibular incisors, the thickness of alveolar bone, the vertical alveolar height and root length were measured. Alveolar bone thickness at the apex in patients with skeletal Class III malocclusion was thinner than normal subjects. The vertical alveolar bone heights at labial and lingual sides in patients with skeletal Class III malocclusion were both reduced compared with normal subjects, especially at the labial side. There were statistically significant correlations between lower incisor inclination and alveolar bone morphology. After orthodontics, the incisors root apex was closer to the lingual side of alveolar bone. The alveolar bone thickness at apex was not statistically changed. The vertical alveolar bone heights at the labial and lingual sides were both significantly reduced especially the lingual side after presurgical orthodontic treatment. The root length was not significantly changed. In conclusion, the alveolar bone thickness at apex is thinner and the vertical alveolar height is reduced at the labial side. Forward movement of lower incisors during presurgical orthodontic treatment can render the lower incisors root apex closer to the lingual side and the vertical alveolar height is reduced. PMID:26550202

  13. Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor.

    PubMed

    Seidel, Kerstin; Ahn, Christina P; Lyons, David; Nee, Alexander; Ting, Kevin; Brownell, Isaac; Cao, Tim; Carano, Richard A D; Curran, Tom; Schober, Markus; Fuchs, Elaine; Joyner, Alexandra; Martin, Gail R; de Sauvage, Frederic J; Klein, Ophir D

    2010-11-01

    In many organ systems such as the skin, gastrointestinal tract and hematopoietic system, homeostasis is dependent on the continuous generation of differentiated progeny from stem cells. The rodent incisor, unlike human teeth, grows throughout the life of the animal and provides a prime example of an organ that rapidly deteriorates if newly differentiated cells cease to form from adult stem cells. Hedgehog (Hh) signaling has been proposed to regulate self-renewal, survival, proliferation and/or differentiation of stem cells in several systems, but to date there is little evidence supporting a role for Hh signaling in adult stem cells. We used in vivo genetic lineage tracing to identify Hh-responsive stem cells in the mouse incisor and we show that sonic hedgehog (SHH), which is produced by the differentiating progeny of the stem cells, signals to several regions of the incisor. Using a hedgehog pathway inhibitor (HPI), we demonstrate that Hh signaling is not required for stem cell survival but is essential for the generation of ameloblasts, one of the major differentiated cell types in the tooth, from the stem cells. These results therefore reveal the existence of a positive-feedback loop in which differentiating progeny produce the signal that in turn allows them to be generated from stem cells. PMID:20978073

  14. Ankylosis of traumatized permanent incisors: pathogenesis and current approaches to diagnosis and management.

    PubMed

    Campbell, Karen M; Casas, Michael J; Kenny, David J

    2005-11-01

    Ankylosis is a known complication of replanted or severely intruded permanent incisors and can be diagnosed by the characteristic sound emitted when the tooth is tapped. The ankylosed incisor demonstrates a lack of physiologic mobility and, later, radiographic evidence of replacement resorption. If the patient is pre-adolescent or adolescent at the time of trauma, infraocclusion relative to adjacent teeth will become apparent during jaw growth. Despite considerable knowledge about the pathogenesis of ankylosis garnered from animal studies and observation of human replanted teeth, there is no known treatment to arrest this condition. Management techniques and rehabilitation options for addressing ankylosis and its consequences are supported by little evidence, do not appear to be widely adopted and do not offer any proven long-term benefit. Avulsion and severe intrusion of permanent incisors are rare injuries. Should the decision be made to intervene by replantation or reduction of the intrusion, the clinician must be prepared to diagnose ankylosis, identify its negative consequences and develop treatment plans accordingly. PMID:16324230

  15. A Digital Stereomicroscopic Study of the Radicular Wall Thickness of Two-Canal Mandibular Incisors

    PubMed Central

    Khedmat, Sedigheh; Mohamadian, Sohayla; Kharrazifard, Mohamad Javad

    2015-01-01

    Objectives: This study aimed to assess the radicular wall thickness in mandibular incisors with two canals and find the maximum and minimum thickness to prevent root canal treatment (RCT) procedural errors. Materials and Methods: A total of 160 extracted mandibular incisors were selected and radiographed; out of which, 55 had two canals. Three parallel transverse sections were made in each tooth at 1mm below the cementoenamel junction (CEJ), mid-root and 1 millimeter to the apex. Specimens were evaluated under a stereomicroscope and the thickness of radicular walls in each section was determined for the buccal, lingual and proximal surfaces. Data were statistically analyzed using Pearson’s correlation coefficient test. Results: The thickness of radicular wall decreased from the cervical towards the apex. In all three sections (cervical, mid-root and apical), the thickness of lingual wall was significantly greater than the buccal wall. Also, the thickness of buccal and lingual walls was significantly higher than that of the proximal walls. Conclusion: The lingual radicular wall had the highest thickness in two-canal mandibular incisors. Therefore, in these teeth, the lingual canal is a better choice for post placement. PMID:26877738

  16. Interproximal wear versus incisors extraction to solve anterior lower crowding: A systematic review

    PubMed Central

    de Almeida, Natlia Valli; Silveira, Giordani Santos; Pereira, Daniele Masterson Tavares; Mattos, Claudia Trindade; Mucha, Jos Nelson

    2015-01-01

    OBJECTIVE: To determine by means of a systematic review the best treatment, whether interproximal wear or incisor extraction, to correct anterior lower crowding in Class I patients in permanent dentition. METHODS: A literature review was conducted using MEDLINE, Scopus and Web of Science to retrieve studies published between January 1950 and October 2013. In selecting the sample, the following inclusion criteria were applied: studies involving interproximal wear and/or extraction of mandibular incisors, as well as Class I cases with anterior lower crowding in permanent dentition. RESULTS: Out of a total of 943 articles found after excluding duplicates, 925 were excluded after abstract analysis. After full articles were read, 13 were excluded by the eligibility criteria and one due to methodological quality; therefore, only fours articles remained: two retrospective and two randomized prospective studies. Data were collected, analyzed and organized in tables. CONCLUSION: Both interproximal wear and mandibular incisor extraction are effective in treating Class I malocclusion in permanent dentition with moderate anterior lower crowding and pleasant facial profile. There is scant evidence to determine the best treatment option for each case. Clinical decision should be made on an individual basis by taking into account dental characteristics, crowding, dental and oral health, patient's expectations and the use of set-up models. PMID:25741827

  17. On the cutting edge of organ renewal: identification, regulation and evolution of incisor stem cells

    PubMed Central

    Hu, Jimmy Kuang-Hsien; Mushegyan, Vagan; Klein, Ophir D.

    2014-01-01

    The rodent incisor is one of a number of organs that grow continuously throughout the life of an animal. Continuous growth of the incisor arose as an evolutionary adaptation to compensate for abrasion at the distal end of the tooth. The sustained turnover of cells that deposit the mineralized dental tissues is made possible by epithelial and mesenchymal stem cells residing at the proximal end of the incisor. A complex network of signaling pathways and transcription factors regulates the formation, maintenance, and differentiation of these stem cells during development and throughout adulthood. Research over the past 15 years has led to significant progress in our understanding of this network, which includes FGF, BMP, Notch, and Hh signaling, as well as cell adhesion molecules and microRNAs. This review surveys key historical experiments that laid the foundation of the field and discusses more recent findings that definitively identified the stem cell population, elucidated the regulatory network, and demonstrated possible genetic mechanisms for the evolution of continuously growing teeth. PMID:24307456

  18. Cultivating Urban Naturalists: Teaching Experiential, Place-Based Learning through Nature Journaling in Central Park

    ERIC Educational Resources Information Center

    Warkentin, Traci

    2011-01-01

    Preservice educators engaged in experiential, place-based learning through a semester-long assignment in which they observed a specific place in Central Park in Manhattan, New York, and kept a nature journal. The assignment was organized around two pivotal elements: direct, sensory experience and time in place. Both elements added vital dimensions

  19. A Traffic Reduction Method for Centralized RSSI-Based Location Estimation in Wireless Sensor Networks

    NASA Astrophysics Data System (ADS)

    Zemek, Radim; Hara, Shinsuke; Yanagihara, Kentaro; Kitayama, Ken-Ichi

    In a centralized localization scenario, the limited throughput of the central node constrains the possible number of target node locations that can be estimated simultaneously. To overcome this limitation, we propose a method which effectively decreases the traffic load associated with target node localization, and therefore increases the possible number of target node locations that can estimated simultaneously in a localization system based on received signal strength indicator (RSSI) and maximum likelihood estimation. Our proposed method utilizes a threshold which limits the amount of forwarded RSSI data to the central node. As the threshold is crucial to the method, we further propose a method to theoretically determine its value. We experimentally verified the proposed method in various environments and the experimental results revealed that the method can reduce the load by 32-64% without significantly affecting the estimation accuracy.

  20. Eigencentrality based on dissimilarity measures reveals central nodes in complex networks

    PubMed Central

    Alvarez-Socorro, A. J.; Herrera-Almarza, G. C.; González-Díaz, L. A.

    2015-01-01

    One of the most important problems in complex network’s theory is the location of the entities that are essential or have a main role within the network. For this purpose, the use of dissimilarity measures (specific to theory of classification and data mining) to enrich the centrality measures in complex networks is proposed. The centrality method used is the eigencentrality which is based on the heuristic that the centrality of a node depends on how central are the nodes in the immediate neighbourhood (like rich get richer phenomenon). This can be described by an eigenvalues problem, however the information of the neighbourhood and the connections between neighbours is not taken in account, neglecting their relevance when is one evaluates the centrality/importance/influence of a node. The contribution calculated by the dissimilarity measure is parameter independent, making the proposed method is also parameter independent. Finally, we perform a comparative study of our method versus other methods reported in the literature, obtaining more accurate and less expensive computational results in most cases. PMID:26603652

  1. Eigencentrality based on dissimilarity measures reveals central nodes in complex networks

    NASA Astrophysics Data System (ADS)

    Alvarez-Socorro, A. J.; Herrera-Almarza, G. C.; Gonzlez-Daz, L. A.

    2015-11-01

    One of the most important problems in complex networks theory is the location of the entities that are essential or have a main role within the network. For this purpose, the use of dissimilarity measures (specific to theory of classification and data mining) to enrich the centrality measures in complex networks is proposed. The centrality method used is the eigencentrality which is based on the heuristic that the centrality of a node depends on how central are the nodes in the immediate neighbourhood (like rich get richer phenomenon). This can be described by an eigenvalues problem, however the information of the neighbourhood and the connections between neighbours is not taken in account, neglecting their relevance when is one evaluates the centrality/importance/influence of a node. The contribution calculated by the dissimilarity measure is parameter independent, making the proposed method is also parameter independent. Finally, we perform a comparative study of our method versus other methods reported in the literature, obtaining more accurate and less expensive computational results in most cases.

  2. Eigencentrality based on dissimilarity measures reveals central nodes in complex networks.

    PubMed

    Alvarez-Socorro, A J; Herrera-Almarza, G C; Gonzlez-Daz, L A

    2015-01-01

    One of the most important problems in complex network's theory is the location of the entities that are essential or have a main role within the network. For this purpose, the use of dissimilarity measures (specific to theory of classification and data mining) to enrich the centrality measures in complex networks is proposed. The centrality method used is the eigencentrality which is based on the heuristic that the centrality of a node depends on how central are the nodes in the immediate neighbourhood (like rich get richer phenomenon). This can be described by an eigenvalues problem, however the information of the neighbourhood and the connections between neighbours is not taken in account, neglecting their relevance when is one evaluates the centrality/importance/influence of a node. The contribution calculated by the dissimilarity measure is parameter independent, making the proposed method is also parameter independent. Finally, we perform a comparative study of our method versus other methods reported in the literature, obtaining more accurate and less expensive computational results in most cases. PMID:26603652

  3. CenLP: A centrality-based label propagation algorithm for community detection in networks

    NASA Astrophysics Data System (ADS)

    Sun, Heli; Liu, Jiao; Huang, Jianbin; Wang, Guangtao; Yang, Zhou; Song, Qinbao; Jia, Xiaolin

    2015-10-01

    Community detection is an important work for discovering the structure and features of complex networks. Many existing methods are sensitive to critical user-dependent parameters or time-consuming in practice. In this paper, we propose a novel label propagation algorithm, called CenLP (Centrality-based Label Propagation). The algorithm introduces a new function to measure the centrality of nodes quantitatively without any user interaction by calculating the local density and the similarity with higher density neighbors for each node. Based on the centrality of nodes, we present a new label propagation algorithm with specific update order and node preference to uncover communities in large-scale networks automatically without imposing any prior restriction. Experiments on both real-world and synthetic networks manifest our algorithm retains the simplicity, effectiveness, and scalability of the original label propagation algorithm and becomes more robust and accurate. Extensive experiments demonstrate the superior performance of our algorithm over the baseline methods. Moreover, our detailed experimental evaluation on real-world networks indicates that our algorithm can effectively measure the centrality of nodes in social networks.

  4. An Innovative Approach to Treat Incisors Hypomineralization (MIH): A Combined Use of Casein Phosphopeptide-Amorphous Calcium Phosphate and Hydrogen PeroxideA Case Report

    PubMed Central

    Mastroberardino, Stefano; Campus, Guglielmo; Strohmenger, Laura; Villa, Alessandro; Cagetti, Maria Grazia

    2012-01-01

    Molar Incisor Hypomineralization (MIH) is characterized by a developmentally derived deficiency in mineral enamel. Affected teeth present demarcated enamel opacities, ranging from white to brown; also hypoplasia can be associated. Patient frequently claims aesthetic discomfort if anterior teeth are involved. This problem leads patients to request a bleaching treatment to improve aestheticconditions.Nevertheless, hydrogen peroxide can produce serious side-effects, resulting from further mineral loss. Microabrasion and/or a composite restoration are the treatments of choice in teeth with mild/moderate MIH, but they also need enamel loss. Recently, a new remineralizing agent based on Casein Phosphopeptide-Amorphous Calcium Phosphate (CPP-ACP) has been proposed to be effective in hypomineralized enamel, improving also aesthetic conditions. The present paper presents a case report of a young man with white opacities on incisors treated with a combined use of CPP-ACP mousse and hydrogen peroxide gel to correct the aesthetic defect. The patient was instructed to use CPP-ACP for two hours per day for three months in order to obtain enamel remineralization followed by a combined use of CPP-ACP and bleaching agent for further two months. At the end of this five-month treatment, a noticeable aesthetic improvement of the opacities was observed. PMID:23243519

  5. Accentuated lines in the enamel of primary incisors from skeletal remains: A contribution to the explanation of early childhood mortality in a medieval population from Poland.

    PubMed

    ??dzi?ska, El?bieta; Lorkiewicz, Wies?aw; Kurek, Marta; Borowska-Strugi?ska, Beata

    2015-07-01

    Physiological disruptions resulting from an impoverished environment during the first years of life are of key importance for the health and biological status of individuals and populations. Studies of growth processes in archaeological populations point to the fact that the main causes of childhood mortality in the past are to be sought among extrinsic factors. Based on this assumption, one would expect random mortality of children, with the deceased individuals representing the entire subadult population. The purpose of this study is to explore whether differences in early childhood survival are reflected in differences in deciduous tooth enamel, which can provide an insight into the development of an individual during prenatal and perinatal ontogeny. Deciduous incisors were taken from 83 individuals aged 2.0-6.5 years from a medieval inhumation cemetery dated AD 1300-1600. Prenatal and postnatal enamel formation time, neonatal line width, and the number of accentuated lines were measured using an optical microscope. The significantly wider neonatal line and the higher frequency of accentuated lines in the enamel of the incisors of children who died at the age of 2-3 years suggest the occurrence of stronger or more frequent stress events in this group. These results indicate that in skeletal populations mortality was not exclusively determined by random external factors. Individuals predisposed by an unfavorable course of prenatal and perinatal growth were more likely to die in early childhood. PMID:25711723

  6. Differentiating Obstructive from Central and Complex Sleep Apnea Using an Automated Electrocardiogram-Based Method

    PubMed Central

    Thomas, Robert Joseph; Mietus, Joseph E.; Peng, Chung-Kang; Gilmartin, Geoffrey; Daly, Robert W.; Goldberger, Ary L.; Gottlieb, Daniel J.

    2007-01-01

    Study Objectives: Complex sleep apnea is defined as sleep disordered breathing secondary to simultaneous upper airway obstruction and respiratory control dysfunction. The objective of this study was to assess the utility of an electrocardiogram (ECG)-based cardiopulmonary coupling technique to distinguish obstructive from central or complex sleep apnea. Design: Analysis of archived polysomnographic datasets. Setting: A laboratory for computational signal analysis. Interventions: None. Measurements and Results: The PhysioNet Sleep Apnea Database, consisting of 70 polysomnograms including single-lead ECG signals of approximately 8 hours duration, was used to train an ECG-based measure of autonomic and respiratory interactions (cardiopulmonary coupling) to detect periods of apnea and hypopnea, based on the presence of elevated low-frequency coupling (e-LFC). In the PhysioNet BIDMC Congestive Heart Failure Database (ECGs of 15 subjects), a pattern of narrow spectral band e-LFC was especially common. The algorithm was then applied to the Sleep Heart Health StudyI dataset, to select the 15 records with the highest amounts of broad and narrow spectral band e-LFC. The latter spectral characteristic seemed to detect not only periods of central apnea, but also obstructive hypopneas with a periodic breathing pattern. Applying the algorithm to 77 sleep laboratory split-night studies showed that the presence of narrow band e-LFC predicted an increased sensitivity to induction of central apneas by positive airway pressure. Conclusions: ECG-based spectral analysis allows automated, operator-independent characterization of probable interactions between respiratory dyscontrol and upper airway anatomical obstruction. The clinical utility of spectrographic phenotyping, especially in predicting failure of positive airway pressure therapy, remains to be more thoroughly tested. Citation: Thomas RJ; Mietus JE; Peng CK; Gilmartin G; Daly RW; Goldberger AL; Gottlieb DJ. Differentiating obstructive from central and complex sleep apnea using an automated electrocardiogram-based method. SLEEP 2007;30(12):1756-1769. PMID:18246985

  7. Simple method of designing centralized PI controllers for multivariable systems based on SSGM.

    PubMed

    Dhanya Ram, V; Chidambaram, M

    2015-05-01

    A method is given to design multivariable PI/PID controllers for stable and unstable multivariable systems. The method needs only the steady state gain matrix (SSGM). The method is based on the static decoupler design followed by SISO PI/PID controllers design and combining the resulted decoupler and the diagonal PI(D) controllers as the centralized controllers. The result of the present method is shown to be equivalent to the empirical method proposed by Davison EJ. Multivariable tuning regulators: the feed-forward and robust control of general servo-mechanism problem. IEEE Trans Autom Control 1976;21:35-41. Three simulation examples are given. The performance of the controllers is compared with that of the reported centralized controller based on the multivariable transfer function matrix. PMID:25530257

  8. The Shannon-entropy-based uncertainty relation for D-dimensional central potentials

    NASA Astrophysics Data System (ADS)

    Rudnicki, ?ukasz; Snchez-Moreno, Pablo; Dehesa, Jess S.

    2012-06-01

    The uncertainty relation based on the Shannon entropies of the probability densities in position and momentum spaces is improved for quantum systems in arbitrary D-dimensional spherically symmetric potentials. To find this, we have used the Lp - Lq norm inequality of De Carli and the logarithmic uncertainty relation for the Hankel transform of Omri. Applications to some relevant three-dimensional central potentials are shown.

  9. Development of a Physiologically-Based Pharmacokinetic Model of the Rat Central Nervous System

    PubMed Central

    Badhan, Raj K. Singh; Chenel, Marylore; Penny, Jeffrey I.

    2014-01-01

    Central nervous system (CNS) drug disposition is dictated by a drug’s physicochemical properties and its ability to permeate physiological barriers. The blood–brain barrier (BBB), blood-cerebrospinal fluid barrier and centrally located drug transporter proteins influence drug disposition within the central nervous system. Attainment of adequate brain-to-plasma and cerebrospinal fluid-to-plasma partitioning is important in determining the efficacy of centrally acting therapeutics. We have developed a physiologically-based pharmacokinetic model of the rat CNS which incorporates brain interstitial fluid (ISF), choroidal epithelial and total cerebrospinal fluid (CSF) compartments and accurately predicts CNS pharmacokinetics. The model yielded reasonable predictions of unbound brain-to-plasma partition ratio (Kpuu,brain) and CSF:plasma ratio (CSF:Plasmau) using a series of in vitro permeability and unbound fraction parameters. When using in vitro permeability data obtained from L-mdr1a cells to estimate rat in vivo permeability, the model successfully predicted, to within 4-fold, Kpuu,brain and CSF:Plasmau for 81.5% of compounds simulated. The model presented allows for simultaneous simulation and analysis of both brain biophase and CSF to accurately predict CNS pharmacokinetics from preclinical drug parameters routinely available during discovery and development pathways. PMID:24647103

  10. Deformations in Central Europe: finite element approach and comparison with GPS-based strain determinations

    NASA Astrophysics Data System (ADS)

    Bogusz, Janusz; Jarosinski, Marek; Araszkiewicz, Andrzej; Figurski, Mariusz; Klos, Anna; Kontny, Bernard

    2013-04-01

    From a geological point of view, the area of Central Europe is very complex. At the same time Europe is being affected by the forces associated with tectonic Africa, as well as Atlantic (ridge) push. In our study the general strain pattern of Central Europe was determined from two different approaches. The first one was finite element approach (FEM). The area of Europe was subdivided into more than 50 elements corresponding to the main geological units and the two-dimensional model of strain field in Central Europe was developed. In order to model a diverse nature of geological structures two approaches were investigated: elastic and more sophisticated made by adding some viscosity properties. Various parameters (Young's modulus, Poisson's ratio, lithosphere thickness, etc.) with the use of the ABAQUS software were implemented. The second approach was based on the method using sites' velocities determined by continuous GPS measurements. EPN network as well as ASG-EUPOS Polish system were utilised. More than 300 European sites with the precisely known velocities in global ITRF2008 reference frame formed the basis for these determinations by using GRID_STRAIN software. This geometrical method allows determining the magnitude and the main strain directions as well. The presentation describes results of numerical calculations and their comparison on the area of Central Europe.

  11. Clinical outcomes of cases with missing lateral incisors treated with the 'T'-Mesialslider.

    PubMed

    Kanavakis, Georgios; Ludwig, Bjrn; Rosa, Marco; Zachrisson, Bjorn; Hourfar, Jan

    2014-09-01

    The objective of this article is to review the fabrication and activation procedures of the 'T'-Mesialslider and to present the clinical outcomes in cases where canine substitution is the treatment of choice for missing maxillary lateral incisors. The 'T'-Mesialslider allows for effective mesial translation of the canines and the posterior dentition, without significant loss of anterior anchorage and with good vertical control. Possible adverse effects of the appliance and clinical recommendations for their management are also discussed. In canine substitution cases with high anchorage demands, the 'T'-Mesialslider provides an effective treatment option. PMID:25138364

  12. Management of avulsed permanent incisors with closed apices and prolonged extraoral dry time.

    PubMed

    Ritwik, Priyanshi; Langha, Yunus; Musselman, Robert J

    2012-10-01

    This article reports the clinical management and outcome of two avulsed permanent incisors that were kept dry for 42 hours. Dental trauma guidelines were followed and clinically successful outcomes were seen until seven months of follow-up. The factors contributing to successful management of this case despite the extreme clinical circumstances were attributed to pulp extirpation prior to replantation, doxycycline soak, fluoride soak, and timely endodontic treatment. Recent advances and alternate treatment modalities reported in literature are evaluated in the discussion. PMID:23316562

  13. Mandibular lateral incisor with Vertucci Type IV root canal morphological system: A rare case report

    PubMed Central

    Aggarwal, Kanika

    2016-01-01

    Abnormalities in the root canal anatomy are commonly occurring phenomenon. A thorough knowledge of root canal anatomy and its variation is necessary for successful completion of endodontic treatment. Mandibular anteriors are known for having extra canals. The role of genetics and racial variations may result in difference of incidence of root number and canal number. This paper attempts at explaining a rare case of successful endodontic management of two-rooted lateral incisor with awareness of data pertaining to number of canals, knowledge of canal morphology, correct radiographic interpretation, and tactile examination of canal wall which are important in detecting the presence of multiple canals. PMID:27003981

  14. Esthetic rehabilitation of severely decayed primary incisors using glass fiber reinforced composite: a case report.

    PubMed

    Metha, Deepak; Gulati, Akanksha; Basappa, N; Raju, O S

    2012-01-01

    Restoration of primary maxillary incisors severely damaged by caries or trauma is a clinical challenge in pediatric dental clinics. Early childhood caries is observed in approximately half the child population. In the past, the only treatment option would have been to extract the affected teeth and replace them with prosthetic substitutes. With the introduction of new adhesive systems and restorative materials, alternative approaches in treating these teeth have been proposed. The purpose of this paper was to describe the rehabilitation of primary anterior teeth in a 5-year-old patient using glass fiber reinforced composite resin as an intracanal post. PMID:22449505

  15. Integrated flight/propulsion control system design based on a centralized approach

    NASA Technical Reports Server (NTRS)

    Garg, Sanjay; Mattern, Duane L.; Bullard, Randy E.

    1989-01-01

    An integrated flight/propulsion control system design is presented for the piloted longitudinal landing task with a modern, statically unstable, fighter aircraft. A centralized compensator based on the Linear Quadratic Gaussian/Loop Transfer Recovery methodology is first obtained to satisfy the feedback loop performance and robustness specificiations. This high-order centralized compensator is then partitioned into airframe and engine sub-controllers based on modal controllability/observability for the compensator modes. The order of the sub-controllers is then reduced using internally-balanced realization techniques and the sub-controllers are simplified by neglecting the insignificant feedbacks. These sub-controllers have the advantage that they can be implemented as separate controllers on the airframe and the engine while still retaining the important performance and stability characteristics of the full-order centralized compensator. Command prefilters are then designed for the closed-loop system with the simplified sub-controllers to obtain the desired system response to airframe and engine command inputs, and the overall system performance evaluation results are presented.

  16. Quantitative analysis of the central-chest lymph nodes based on 3D MDCT image data

    NASA Astrophysics Data System (ADS)

    Lu, Kongkuo; Bascom, Rebecca; Mahraj, Rickhesvar P. M.; Higgins, William E.

    2009-02-01

    Lung cancer is the leading cause of cancer death in the United States. In lung-cancer staging, central-chest lymph nodes and associated nodal stations, as observed in three-dimensional (3D) multidetector CT (MDCT) scans, play a vital role. However, little work has been done in relation to lymph nodes, based on MDCT data, due to the complicated phenomena that give rise to them. Using our custom computer-based system for 3D MDCT-based pulmonary lymph-node analysis, we conduct a detailed study of lymph nodes as depicted in 3D MDCT scans. In this work, the Mountain lymph-node stations are automatically defined by the system. These defined stations, in conjunction with our system's image processing and visualization tools, facilitate lymph-node detection, classification, and segmentation. An expert pulmonologist, chest radiologist, and trained technician verified the accuracy of the automatically defined stations and indicated observable lymph nodes. Next, using semi-automatic tools in our system, we defined all indicated nodes. Finally, we performed a global quantitative analysis of the characteristics of the observed nodes and stations. This study drew upon a database of 32 human MDCT chest scans. 320 Mountain-based stations (10 per scan) and 852 pulmonary lymph nodes were defined overall from this database. Based on the numerical results, over 90% of the automatically defined stations were deemed accurate. This paper also presents a detailed summary of central-chest lymph-node characteristics for the first time.

  17. Sulcus-Based MR Analysis of Focal Cortical Dysplasia Located in the Central Region

    PubMed Central

    Roca, Pauline; Mellerio, Charles; Chassoux, Francine; Rivire, Denis; Cachia, Arnaud; Charron, Sylvain; Lion, Stphanie; Mangin, Jean-Franois; Devaux, Bertrand; Meder, Jean-Franois; Oppenheim, Catherine

    2015-01-01

    Objective Focal cortical dysplasias (FCDs) are mainly located in the frontal region, with a particular tropism for the central sulcus. Up to 30% of lesions are undetected (magnetic resonance [MR]-negative FCD patients) or belatedly diagnosed by visual analysis of MR images. We propose an automated sulcus-based method to analyze abnormal sulcal patterns associated with central FCD, taking into account the normal interindividual sulcal variability. Methods We retrospectively studied 29 right-handed patients with FCD in the central region (including 12 MR negative histologically-confirmed cases) and 29 right-handed controls. The analysis of sulcal abnormalities from T1-weighted MR imaging (MRI) was performed using a graph-based representation of the cortical folds and an automated sulci recognition system, providing a new quantitative criterion to describe sulcal patterns, termed sulcus energy. Results Group analysis showed that the central sulcus in the hemisphere ipsilateral to the FCD exhibited an abnormal sulcal pattern compared with controls (p = 0.032). FCDs were associated with abnormal patterns of the central sulci compared with controls (p = 0.006), a result that remained significant when MR-negative and MR-positive patients were considered separately, while the effects of sex, age and MR-field were not significant. At the individual level, sulcus energy alone failed to detect the FCD lesion. We found, however, a significant association between maximum z-scores and the site of FCD (p = 0.0046) which remained significant in MR-negative (p = 0.024) but not in MR-positive patients (p = 0.058). The maximum z-score pointed to an FCD sulcus in four MR-negative and five MR-positive patients. Conclusions We identified abnormal sulcal patterns in patients with FCD of the central region compared with healthy controls. The abnormal sulcal patterns ipsilateral to the FCD and the link between sulcus energy and the FCD location strengthen the interest of sulcal abnormalities in FCD patients. PMID:25822985

  18. Assessing the ecological base and peak flow of the alpine streams in Central Taiwan

    NASA Astrophysics Data System (ADS)

    Wei, C.; Yang, P. S.; Tian, P. L.

    2009-04-01

    The ecological base and peak flow are crucial for the assessment and design for habitat rehabilitation and recovery. The amount of discharge affects the aquatic creatures and may severely damage the existence and balance of the community under extreme conditions. Aquatic insects are selected as the target species in this study to evaluate the influence of the discharge and to estimate the ecological base and peak flow. The distribution of the number of species and abundance (density) versus discharge is assessed to define the critical discharge. Two streams located at the alpine area in central Taiwan are selected as the study area to evaluate the base and peak flow. From the preliminary data (Aug 2008 to Dec 2008) collected from one stream Creek C originating from Sitou Area in Central Taiwan shows that the abundance of several species varies with the discharge. The dominate family and genus of aquatic insects is Baetidae (Order Ephemeroptera) and Baetis spp. that accounts for 32.47% and 31.11%, respectively. The Hilsenhoff family biotic index (FBI) shows that the water quality is classified to "Good" and "Very Good" level while the river pollution index (RPI) indicates that the stream is non-polluted. The discharge of base flow interpreted from the 95% curve of duration for the daily discharge is 0.0234 cms. Consistent observations are yet to be collected to yield more accurate result and ecological peak flow in rainy and typhoon seasons.

  19. Prevalence of lesions in incisors of mule deer from Colorado Springs, Colorado

    SciTech Connect

    Borrero, L.M.; Scanlon, P.F.

    1995-12-31

    Lesions in teeth may be influenced by exposure to fluorides, malnutrition and trauma. Incisors of 228 mule deer (Odocoileus hemionus) taken from the USAF Academy, Colorado Springs, CO during the 1993 hunting season were examined for lesions. A classification scheme (scale = 0--5) for lesions was derived from the method of Shupe et al. 1963. Lesions were present in at least one incisor of 84.6% of deer. Of the deer with lesions, 86% had at least one tooth with very slight effect (one to few white spots), 9.8% had a slight effect (generalized mottling), 2.6% had a moderate effect (generalized mottling and wear), 10.04% had a marked effect (mottling and hypoplasia of the enamel) , and 0.5 % ad severe effects (hypoplasia of the enamel and abnormal wear). Lesions that affect the enamel are produced during the period of formation of the tooth. The severity of lesions depends on the cause and the length of exposure to the causative agent. Generally mottling and hypoplasia of the enamel are associated with fluorosis. The relationship of lesions to bone and tooth fluoride concentrations was examined.

  20. Resorption of the mouse incisor after the application of cold to the periodontal attachment apparatus.

    PubMed

    Wesselink, P R; Beertsen, W; Everts, V

    1986-07-01

    In order to study in detail the processes leading to the resorption and ankylosis of teeth after trauma, the effects of cold application on the periodontal tissues were studied in the mouse. Liquid nitrogen was applied locally to the outer surface of the lower jaw which resulted in a freezing of the incisor and its surrounding tissues. The healing processes in the damaged periodontal ligament and the accompanying phenomena of ankylosis and dental root resorption were investigated histologically at both the light and electron microscopic levels. As a result of cold application, the cells in the periodontal ligament were killed. After a few days, the ligament started to be repopulated with cells like fibroblasts and macrophages. From 3 days on, mineral crystallites were deposited along the cementum covering the lingual, mesial, and lateral surfaces of the incisor, finally resulting in a 4-6 micron thick layer. During the period of 7-12 days following cold application, this layer of mineralized material started to be phagocytosed and degraded, presumably by mononuclear cells. Finally, extensive root resorption and some ankylosis between the tooth and the alveolar bone were observed. In the resorbed areas, cells were seen which could not be distinguished from osteoclasts. In some instances, their ruffled border was in close apposition with each of the three mineralized tissues--dentin, cementum, and alveolar bone. It is hypothesized that the deposition and subsequent phagocytosis of mineralized material along the root surface may be an important factor in the initiation of dental root resorption. PMID:3089560

  1. Adaptive diversity of incisor enamel microstructure in South American burrowing rodents (family Ctenomyidae, Caviomorpha)

    PubMed Central

    Vieytes, Emma C; Morgan, Cecilia C; Verzi, Diego H

    2007-01-01

    The aim of this study was to analyse the morphofunctional and adaptive significance of variation in the upper incisor enamel microstructure of South American burrowing ctenomyids and other octodontoid taxa. We studied the specialized subterranean tooth-digger Eucelophorus chapalmalensis (Pliocene Middle Pleistocene), and compared it with other fossil and living ctenomyids with disparate digging adaptations, two fossorial octodontids and one arboreal echimyid. Morphofunctionally significant enamel traits were quite similar among the species studied despite their marked differences in habits, digging behaviour and substrates occupied, suggesting a possible phylogenetic constraint for the Octodontoidea. In this context of relative similarity, the inclination of HunterSchreger bands, relative thickness of external index (EI) and prismless enamel zone were highest in Eucelophorus, in agreement with its outstanding craniomandibular tooth-digging specialization. Higher inclination of HunterSchreger bands reinforces enamel to withstand high tension forces, while high external index provides greater resistance to wear. Results suggest increased frequency of incisor use for digging in Eucelophorus, which could be related to a more extreme tooth-digging strategy and/or occupancy of hard soils. Higher external index values as recurring patterns in distant clades of tooth-digging rodents support an adaptive significance of this enamel trait. PMID:17584181

  2. Investigation of lay knowledge of the management of avulsed permanent incisors.

    PubMed

    Hamilton, F A; Hill, F J; Mackie, I C

    1997-02-01

    The prognosis of replanted avulsed permanent incisors depends largely on prompt and appropriate emergency management. The aim of this study was to investigate lay knowledge and attitudes in this respect. Postal questionnaires were sent to all physical education teachers, school nurses and secretaries, attendants in swimming baths and leisure centres and to 220 parents of teenage children in a defined area of North West England. The overall questionnaire response rate was 86.9%. Knowledge of methods of dealing with this problem was generally inadequate in both parents and the other groups. Although 53.6% of respondents claimed to have received first aid training only 3.1% could remember dental injuries being included. There was evidence that dental health education in this field can be effective, since the highest mean knowledge score was found in the 11.5% of respondents who recalled receiving advice from sources such as posters, magazines and newspapers. More than 80% of the respondents stated that they would not want to replant an avulsed incisor themselves, the main reason being lack of knowledge and training. It is suggested that there is a need for potentially effective dental health education in relation to this problem. PMID:9206384

  3. Shear bond strength of dentin and deproteinized enamel of AI mouse incisors

    PubMed Central

    Pugach, M.K.; Ozer, F.; Mulmadgi, R.; Li, Y.; Suggs, C.; Wright, J.T.; Bartlett, J.D.; Gibson, C.W.; Lindemeyer, R.G.

    2014-01-01

    Purpose To investigate the adhesion through shear bond strength (SBS) testing of a resin composite bonded with a self-etching bonding system (SEB) to amelogenesis imperfecta (AI)-affected deproteinized mouse enamel or dentin; and to compare wild-type (WT), amelogenin null (AmelxKO) and matrix metalloproteinase-20 null (Mmp20KO) enamel and dentin phenotypes using microCT and nanoindentation. Methods Enamel incisor surfaces of WT, AmelxKO and Mmp20KO mice were treated with SEB with and without NaOCl and tested for SBS. Incisor dentin was also treated with SEB and tested for SBS. These surfaces were further examined by SEM. MicroCT and nanoindentation analyses were performed on mouse dentin and enamel. Data were analyzed for significance by ANOVA. Results Deproteinization did not improve SBS of SEB to these AI-affected enamel surfaces. SBS of AmelxKO teeth was similar in dentin and enamel; however, it was higher in Mmp20KO dentin. The nanohardness of knockout enamel was significantly lower than WT, while knockout dentin nanohardness was not different from WT. Conclusions Using animal AI models, it was demonstrated that enamel NaOCl deproteinization of hypoplastic and hypoplastic-hypomaturation enamel did not increase shear bond strength while removal of the defective enamel allowed optimal dentin bonding. PMID:25303500

  4. The influence of fluoride administration on the structure of proteoglycans in the developing rat incisor.

    PubMed Central

    Smalley, J W; Embery, G

    1980-01-01

    1. 35S-labelled chondroitin 4-sulphate proteoglycan was isolated from the mineralized elements of the developing incisor teeth of Harvard rats receiving intraperitoneal administration of Na235SO4. 2. The chondroitin 4-sulphate proteoglycan underwent a decrease in molecular size in fluorotic teeth as judged by gel filtration on Sepharose 2B. 3. When examined by anion-exchange chromatography on DEAE cellulose-52, the proteoglycan from fluorotic teeth resolved into four peaks in comparison with the material from non-fluorotic teeth, which exhibited only a single major peak. 4. Both the single peak from non-fluoridated teeth and the four peaks from the fluorotic teeth were further resolved on cellulose acetate electrophoresis. 5. Isolated chondroitin 4-sulphate chains obtained from fluorotic teeth also were of smaller molecular size as judged by gel filtration on Sephadex G-150. 6. Some possible influences of fluoride on the metabolism of these connective-tissue components in the developing rat incisor are discussed. PMID:6781478

  5. Retreatment of a Maxillary Lateral Incisor With Two Separate Root Canals Confirmed With Cone Beam Computed Tomography

    PubMed Central

    Aydemir, Seda; Helvacioglu-Yigit, Dilek; Sinanoglu, Alper; Ozel, Emre

    2015-01-01

    The purpose of this report is to present a rare case of a maxillary lateral incisor exhibiting two separate root canals confirmed by cone-beam computed tomography (CBCT). A 65-year-old female patient with an esthetic complaint regarding her maxillary left lateral incisor was referred to our clinic. During a radiographical examination, an endodontically treated root canal and an extra root canal with an apical lesion were observed. The retreatment was performed. CBCT findings confirmed the root canal mophology of the maxillary left lateral with two distinct canals. We conclude that the CBCT imaging is an adjunctive tool for better assessment of complex root canal systems. PMID:26015823

  6. Theoretical Study of the Effect of Enamel Parameters on Laser-Induced Surface Acoustic Waves in Human Incisor

    NASA Astrophysics Data System (ADS)

    Yuan, Ling; Sun, Kaihua; Shen, Zhonghua; Ni, Xiaowu; Lu, Jian

    2015-06-01

    The laser ultrasound technique has great potential for clinical diagnosis of teeth because of its many advantages. To study laser surface acoustic wave (LSAW) propagation in human teeth, two theoretical methods, the finite element method (FEM) and Laguerre polynomial extension method (LPEM), are presented. The full field temperature values and SAW displacements in an incisor can be obtained by the FEM. The SAW phase velocity in a healthy incisor and dental caries is obtained by the LPEM. The methods and results of this work can provide a theoretical basis for nondestructive evaluation of human teeth with LSAWs.

  7. Nasomaxillary osteotomy in lesions of the central compartment of the middle cranial base.

    PubMed

    Karci, B; Oner, K; Gnhan, O; Ovl, I; Bilgen, C

    2001-09-01

    The pituitary fossa, sphenoid rostrum, sphenoid sinus, nasopharynx, pterygopalatine fossa and clivus are the components of the central compartment of the middle cranial base. It is a surgical challenge to gain access to this region. This fact has led to the development of a number of surgical procedures reported in the literature. However, none of these techniques can provide a wide and direct exposure to the middle cranial fossa without morbidity on its own. In this report, nasomaxillary osteotomy is described as a satisfactory alternative to reach the middle cranial fossa. With the nasomaxillary osteotomy technique, a wide access can be obtained to the central compartment of the skull base, caudally till the inferior clivus and upper cervical vertebrae (C1, C2). Since bilateral, internal carotid arteries are in sight laterally, the technique provides a secure resection of tumors with marked lateral extensions. Repositioning the translocated bone segment, surrounding the apertura piriformis, results in satisfactory cosmesis postoperatively. The technique is discussed on the basis of eight cases with the histopathological diagnosis of squamous cell carcinoma (1 case), olfactory neuroblastoma (2 cases), chordoma (2 cases) and juvenile nasopharyngeal angiofibroma (3 cases). No vascular complication has been encountered. One chordoma patient died of the disease in the follow-up period. All other cases, including one squamous cell carcinoma patient, are alive and disease-free without cosmetic deformity. In conclusion, nasomaxillary osteotomy provides a wide and direct exposure to the central compartment of the skull base in a relatively short period of time, securing the vascular and neural structures. Besides, it offers the advantage that it can be combined with other techniques in extensive tumors, while cosmesis and nasal functions are preserved. PMID:11721508

  8. Structural analysis of the central Columbia Plateau utilizing radar, digital topography, and magnetic data bases

    SciTech Connect

    Thiessen, R.L.; Eliason, J.R.; Johnson, L.K.; Brougher, C.W.; Foley, M.G.; Beaver, D.E.

    1991-08-01

    Interest in the Hanford site (Washington) as a nuclear production, power, and waste disposal site has led to generation of a vast quantity of geophysical and remote sensing data sets of the central Columbia Plateau. To data, these various studies, including at least 13 independent magnetic linear and image lineament studies, have not been adequately correlated. Therefore, these studies provide a unique opportunity to compare and contrast the viability of the different geophysical and remote sensing techniques. The geology of the central Columbia Plateau is characterized by subdued topography and limited outcrop, with most of the exposure concentrated in localized folded/faulted mountains (the Yakima folds) and along river canyons. In order to efficiently compare lineament data bases, we have written an automated computer routine that correlated lineaments that are within a user specified distance of each other. The angle between their trends has to be less than an input maximum separation angle. If more than two lineament maps exist for the area, the analyst may also specify the minimum number of times each structure must be seen. The lineament correlation routine was applied to data bases of all aeromagnetic linears as well as lineaments seen on radar and a digital elevation model DEM image. Geologic structures align with a set of three-dimensional planar structures identified with our Geologic Spatial Analysis (GSA) system. The GSA analysis is based upon computer automated detection of valley bottoms as defined by a DEM.

  9. Centralized PI control for high dimensional multivariable systems based on equivalent transfer function.

    PubMed

    Luan, Xiaoli; Chen, Qiang; Liu, Fei

    2014-09-01

    This article presents a new scheme to design full matrix controller for high dimensional multivariable processes based on equivalent transfer function (ETF). Differing from existing ETF method, the proposed ETF is derived directly by exploiting the relationship between the equivalent closed-loop transfer function and the inverse of open-loop transfer function. Based on the obtained ETF, the full matrix controller is designed utilizing the existing PI tuning rules. The new proposed ETF model can more accurately represent the original processes. Furthermore, the full matrix centralized controller design method proposed in this paper is applicable to high dimensional multivariable systems with satisfactory performance. Comparison with other multivariable controllers shows that the designed ETF based controller is superior with respect to design-complexity and obtained performance. PMID:24954810

  10. Central skull base osteomyelitis: new insights and implications for diagnosis and treatment.

    PubMed

    Ridder, Gerd J; Breunig, Christine; Kaminsky, Jan; Pfeiffer, Jens

    2015-05-01

    Central skull base osteomyelitis (SBO) is a life-threatening disease originating from ear and from sinonasal infections. The intention of this study was to evaluate contemporary trends in etiology, diagnosis, management, and outcome of SBO and to draw the clinician's attention on this probably underestimated disease. Over a 6-year period we performed this systematic study in an academic quaternary medical care and skull base center including 20 patients (mean age 63.7 years) with central SBO, which is one of the largest series from a single center. In contrast to previous studies we explicitly excluded infections limited to malignant external otitis only but did not restrict central SBO to conditions unrelated to aural pathology. Fifteen patients had otogenic and five sinugenic SBO; four patients had fungal or mixed fungal infections. Pre-existing illnesses altering bone vascularization were detected in 70 % of the patients and had a negative effect on the improvement of cranial nerve palsies that were found in 14 patients. In relation, patients with otogenic SBO more often had local and systemic predisposing factors. Contrary to previous studies 16 patients (80 %) underwent surgical therapy and none of our patients died. A meta-analysis of five recent studies was done and compared with our own data and two previous meta-analyses. The present study highlights several important aspects with major implications for diagnosis and treatment of SBO that have not been adequately addressed as yet. In contrast to the restrictive attitude towards surgery in literature we recommend early and radical operative treatment to reduce its mortality. PMID:25381580

  11. Central obesity in Yemeni children: A population based cross-sectional study

    PubMed Central

    Bamoshmoosh, Mohamed; Massetti, Luciano; Aklan, Hameed; Al-Karewany, Mahdi; Goshae, Husni Al; Modesti, Pietro Amedeo

    2013-01-01

    AIM: To establish percentile curves and to explore prevalence and correlates of central obesity among Yemeni children in a population based cross-sectional study. METHODS: A representative sample of 3114 Yemeni children (1564 boys, 1550 girls) aged 6-19 years participating in the HYpertension and Diabetes in Yemen study was studied. Data collection was conducted at home by survey teams composed of two investigators of both genders. Study questionnaire included questions about demographics, lifestyle, and medical history. Anthropometric measurements included body weight, height, waist circumference (WC) and hip circumferences. Waist to hip ratio (WHR) and waist-to-height ratio (WHtR) were then calculated. Age and gender specific smoothed percentiles of WC, WHR, and WHtR were obtained using lambda-mu-sigma parameters (LMS method). The independent predictors of central obesity defined as (1) WC percentile ? 90th; (2) WHtR ? 0.5; or (3) WC percentile ? 90th and WHtR ? 0.5, were identified at multivariate logistic regression analysis adjusted for age, gender, urban/rural location, years of school education, sedentary/active life-style. RESULTS: Percentile curves for WC, WHR and WHtR are presented. Average WC increased with age for both genders. Boys had a higher WC than girls until early adolescence and thereafter girls had higher values than boys. WHR decreased both in boys and girls until early adolescence. Thereafter while in boys it plateaued in girls it continued to decrease. Mean WHtR decreased until early adolescence with no gender related differences and thereafter increased more in girls than in boys towards adult age. Prevalence of central obesity largely varied according to the definition used which was 10.9% for WC ? 90th percentile, 18.3% for WHtR ? 0.5, and 8.6% when fulfilling both criteria. At adjusted logistic regression WC ? 90th percentiles and WHtR ? 0.5 were less prevalent in rural than in urban areas (OR = 0.52, 95%CI: 0.41-0.67 and 0.66, 0.54-0.79 respectively), being more prevalent in children with sedentary lifestyle rather than an active one (1.52, 95%CI: 1.17-1.98 and 1.42, 95%CI: 1.14-1.75, respectively). CONCLUSION: Yemeni children central obesity indices percentile curves are presented. Central obesity prevalence varied according to the definition used and was more prevalent in urban sedentary subjects. PMID:24009819

  12. New approaches to solve old water problems: community based organizations in Central Asia

    NASA Astrophysics Data System (ADS)

    Nurymgereyev, Kanysh

    2010-05-01

    The dry summer of 2009 has once again shown unsteadiness of economy of the Central-Asian countries, first of all, in agricultural sector and serious dependence of the region on water resources. For example, decreasing of water level in Toktogul reservoir forces the Government of the Kyrgyz Republic, the country where the largest rivers of the Central Asia originate, to the systematic switching-off of the electricity in three regions. Already in the spring of 2009, the experts predicted decreasing of gross production of agriculture in region, especially for the main cultures of cotton and rice. Coupled by natural cataclysms, the problems with water resources management have seriously aggravated conditions that are directly reflected on the livelihood of the rural population of Central Asia. This demands a search for new approaches and methods of solution of the main problems of water resources management. Despite the fact that the main issues of water distribution are solved at a level of the governments of the countries of Central Asia, a serious role in this process is associated directly to local water users. In recent years in some countries of the region, a process of creation of new community based Institutes of water resources management like Water Users Associations of (WUA) has started. The main idea for creation of these organizations is the necessity to involve the local water users like farmers to the process of water resources management and distribution. However, activity of the WUAs in the region has shown certain weaknesses both regarding the legal status of these organizations and institutional development. The main weakness of many WUAs is a lack of opportunities and mechanisms of involving of associations in decision-making processes. Members of WUAs have an opportunity to participate in distribution of water only within the borders of the associations while the main requirement of efficient water resources management is the principle of the integrated water management. The essence of this principle is that issues of water use and water distribution should be solved in coordination and in view of interests of all partners from other countries of the region. The next important issue is the necessity to strengthen the institutional capacity of WUAs. First of all, it is related to providing new approaches in training of members of associations in organizational management, fundraising, and modern technologies of natural resources management. It would be useful as well to strengthen cooperation between WUAs of neighboring countries in order to create information exchange and distribution of best practices between them. Hence, cooperation between the WUAs of the Central Asia countries could become an example for local governments for an integrated solution of problems of distribution and water resources management in the region.

  13. Restoring the vertical dimension of mandibular incisors with bonded ceramic restorations.

    PubMed

    Wylie, S G; Tan, H K; Brooke, K

    2000-06-01

    Mandibular incisors are difficult to restore with conventional anterior crowns due to their small axial diameters. Crown preparation risks pulp exposure and results in a thin core of dentine. An experiment was designed to determine if increasing the thickness of ceramic to restore incisal edges affects the load at the point of restoration failure. Forty-eight mandibular incisors were randomly divided into four groups. The incisal edges of the teeth in three groups were reduced so that the coronal height was 7.5 mm (Group A), 6.5 mm (Group B), and 5.5 mm (Group C). Group D was designated as the experimental control. A fifth group (Group E), independent of the random sample, was introduced to the study for discussion purposes and was characterized by each of the incisors having an intact incisal edge of enamel. Groups A, B and C were prepared in a standard fashion for ceramic veneer restorations that were constructed to restore the vertical height of each tooth to 8.5 mm. Prior to cementation, the preparation surfaces were analysed and the relative surface areas of enamel and dentine were calculated. The ceramic restorations were cemented using a resin luting agent. The teeth were then thermocycled prior to loading at 135 degrees C until failure. The mean fracture load was 305 N (SD 134 N) for Group A, 403 N (SD 101 N) for Group B, 515 N (SD 296 N) for Group C, 587 N (SD 187 N) for Group D and 395 N (SD 129 N) for Group E. As determined by analysis of variance followed by a Sheff multiple comparison test there was a significant difference (p < or = 0.01) between Group A and Group D. There were no significant correlations of load at failure with the percentage of exposed dentine, enamel surface area, total preparation surface area, and the incisal surface area. The patterns of failure of the fractured specimens were also analysed. There were significantly (p < or = 0.05) greater fractures of the ceramic restorations when they were bonded with the minimum incisal thickness of ceramic. PMID:10925503

  14. Base Excision Repair in Physiology and Pathology of the Central Nervous System

    PubMed Central

    Bosshard, Matthias; Markkanen, Enni; van Loon, Barbara

    2012-01-01

    Relatively low levels of antioxidant enzymes and high oxygen metabolism result in formation of numerous oxidized DNA lesions in the tissues of the central nervous system. Accumulation of damage in the DNA, due to continuous genotoxic stress, has been linked to both aging and the development of various neurodegenerative disorders. Different DNA repair pathways have evolved to successfully act on damaged DNA and prevent genomic instability. The predominant and essential DNA repair pathway for the removal of small DNA base lesions is base excision repair (BER). In this review we will discuss the current knowledge on the involvement of BER proteins in the maintenance of genetic stability in different brain regions and how changes in the levels of these proteins contribute to aging and the onset of neurodegenerative disorders. PMID:23203191

  15. Novel treatment of equine odontoclastic tooth resorption and hypercementosis of incisor teeth in a 22-year-old Arabian mare

    PubMed Central

    Grier-Lowe, Candace K.; Anthony, James

    2015-01-01

    Equine odontoclastic tooth resorption and hypercementosis is a rarely reported condition in the incisor and canine teeth of older horses. Histologically, there is internal and external resorption of the tooth with formation of excessive cementum. Once lesions become infected or supragingival this condition is very painful. The clinical manifestation, diagnosis and treatment of hypercementosis in an Arabian mare are described. PMID:26246633

  16. The effects of day length, hibernation, and ambient temperature on incisor dentin in the Turkish hamster (Mesocricetus brandti).

    PubMed

    Batavia, Mariska; Nguyen, George; Zucker, Irving

    2013-05-01

    Dentin is deposited on a circadian basis, and daily layers manifest as bands on the medial surfaces of rodent incisors. Hibernation alters dentin deposition, and a distinct hibernation mark has been described on incisor surfaces of several rodent species; the factors that influence the morphology of this mark are poorly understood. We tested the effects of day length, torpor expression, and ambient temperature on incisor surface morphology in Turkish hamsters housed in one of four conditions: long days (LDs) at 22C, short days (SDs) at 22C, SDs at 5C, and SDs at 13C. Body temperature was monitored continuously with implanted radio transmitters, and teeth examined postmortem. Teeth of SD hamsters had narrower, less distinct circadian increments than those of LD hamsters, but the width of ultradian increments was similar in both photoperiods. Hibernation at both 5 and 13C was associated in most specimens with very narrow, sharply defined dentin increments and increased tooth heterogeneity. Hamsters in SDs at 5C that did not hibernate lacked characteristic hibernation increments. At 5C, but not 13C, the number and cumulative width of hibernation increments were related to number and cumulative duration of periodic arousals. Our results suggest that incremental deposition of dentin in rodent incisors may be a useful trait for characterizing hibernation behavior in both evolutionary and historical contexts. PMID:23233167

  17. Novel treatment of equine odontoclastic tooth resorption and hypercementosis of incisor teeth in a 22-year-old Arabian mare.

    PubMed

    Grier-Lowe, Candace K; Anthony, James

    2015-08-01

    Equine odontoclastic tooth resorption and hypercementosis is a rarely reported condition in the incisor and canine teeth of older horses. Histologically, there is internal and external resorption of the tooth with formation of excessive cementum. Once lesions become infected or supragingival this condition is very painful. The clinical manifestation, diagnosis and treatment of hypercementosis in an Arabian mare are described. PMID:26246633

  18. Mobile devices for community-based REDD+ monitoring: a case study for Central Vietnam.

    PubMed

    Pratihast, Arun Kumar; Herold, Martin; Avitabile, Valerio; de Bruin, Sytze; Bartholomeus, Harm; Souza, Carlos M; Ribbe, Lars

    2012-01-01

    Monitoring tropical deforestation and forest degradation is one of the central elements for the Reduced Emissions from Deforestation and Forest Degradation in developing countries (REDD+) scheme. Current arrangements for monitoring are based on remote sensing and field measurements. Since monitoring is the periodic process of assessing forest stands properties with respect to reference data, adopting the current REDD+ requirements for implementing monitoring at national levels is a challenging task. Recently, the advancement in Information and Communications Technologies (ICT) and mobile devices has enabled local communities to monitor their forest in a basic resource setting such as no or slow internet connection link, limited power supply, etc. Despite the potential, the use of mobile device system for community based monitoring (CBM) is still exceptional and faces implementation challenges. This paper presents an integrated data collection system based on mobile devices that streamlines the community-based forest monitoring data collection, transmission and visualization process. This paper also assesses the accuracy and reliability of CBM data and proposes a way to fit them into national REDD+ Monitoring, Reporting and Verification (MRV) scheme. The system performance is evaluated at Tra Bui commune, Quang Nam province, Central Vietnam, where forest carbon and change activities were tracked. The results show that the local community is able to provide data with accuracy comparable to expert measurements (index of agreement greater than 0.88), but against lower costs. Furthermore, the results confirm that communities are more effective to monitor small scale forest degradation due to subsistence fuel wood collection and selective logging, than high resolution remote sensing SPOT imagery. PMID:23344371

  19. Mobile Devices for Community-Based REDD+ Monitoring: A Case Study for Central Vietnam

    PubMed Central

    Pratihast, Arun Kumar; Herold, Martin; Avitabile, Valerio; de Bruin, Sytze; Bartholomeus, Harm; Souza, Carlos M.; Ribbe, Lars

    2013-01-01

    Monitoring tropical deforestation and forest degradation is one of the central elements for the Reduced Emissions from Deforestation and Forest Degradation in developing countries (REDD+) scheme. Current arrangements for monitoring are based on remote sensing and field measurements. Since monitoring is the periodic process of assessing forest stands properties with respect to reference data, adopting the current REDD+ requirements for implementing monitoring at national levels is a challenging task. Recently, the advancement in Information and Communications Technologies (ICT) and mobile devices has enabled local communities to monitor their forest in a basic resource setting such as no or slow internet connection link, limited power supply, etc. Despite the potential, the use of mobile device system for community based monitoring (CBM) is still exceptional and faces implementation challenges. This paper presents an integrated data collection system based on mobile devices that streamlines the community-based forest monitoring data collection, transmission and visualization process. This paper also assesses the accuracy and reliability of CBM data and proposes a way to fit them into national REDD+ Monitoring, Reporting and Verification (MRV) scheme. The system performance is evaluated at Tra Bui commune, Quang Nam province, Central Vietnam, where forest carbon and change activities were tracked. The results show that the local community is able to provide data with accuracy comparable to expert measurements (index of agreement greater than 0.88), but against lower costs. Furthermore, the results confirm that communities are more effective to monitor small scale forest degradation due to subsistence fuel wood collection and selective logging, than high resolution remote sensing SPOT imagery. PMID:23344371

  20. Prediction of width of un-erupted incisors, canines and premolars in a Ugandan population: A cross sectional study

    PubMed Central

    2012-01-01

    Background Accurate prediction of the space forms an important part of an orthodontic assessment in the mixed dentition. However the most commonly used methods of space analysis are based on data developed on Caucasian populations. In order to provide more accurate local data we set out to develop a formula for predicting the widths of un-erupted canines and premolars for a Ugandan population and to compare the predicted widths of the teeth from this formula with those obtained from Moyers tables, and Tanaka and Johnstons equations. Methods Dental casts were prepared using mandibular and maxillary arch impressions of 220 children (85 boys/135 girls) aged 1217?years recruited from schools in Kampala, Uganda. The mesio-distal width of the mandibular incisors, mandibular and maxillary canines and premolars were measured with a pair of digital calipers. Based on regression analysis, predictive equations were derived and the findings were compared with those presented in Moyers probability tables, and Tanaka and Johnstons equations. Results There were no statistically significant differences between the tooth widths predicted by our equations and those from Moyers probability tables at the 65th and 75th percentile probabilities for the girls and at 75th level in boys in the mandibular arch. While in the maxillary arch no statistically significant differences at the 75th and 95th levels were noted in girls. There were statistically significant differences between predicted tooth sizes using equations from the present study and those predicted from the Tanaka and Johnston regression equations. Conclusions In this Ugandan population, Moyers probability tables could be used to predict tooth widths at specific percentile probabilities, but generally, Tanaka and Johnston technique tends to overestimate the tooth widths. PMID:22824246

  1. CENTERA: A Centralized Trust-Based Efficient Routing Protocol with Authentication for Wireless Sensor Networks †

    PubMed Central

    Tajeddine, Ayman; Kayssi, Ayman; Chehab, Ali; Elhajj, Imad; Itani, Wassim

    2015-01-01

    In this paper, we present CENTERA, a CENtralized Trust-based Efficient Routing protocol with an appropriate authentication scheme for wireless sensor networks (WSN). CENTERA utilizes the more powerful base station (BS) to gather minimal neighbor trust information from nodes and calculate the best routes after isolating different types of “bad” nodes. By periodically accumulating these simple local observations and approximating the nodes' battery lives, the BS draws a global view of the network, calculates three quality metrics—maliciousness, cooperation, and compatibility—and evaluates the Data Trust and Forwarding Trust values of each node. Based on these metrics, the BS isolates “bad”, “misbehaving” or malicious nodes for a certain period, and put some nodes on probation. CENTERA increases the node's bad/probation level with repeated “bad” behavior, and decreases it otherwise. Then it uses a very efficient method to distribute the routing information to “good” nodes. Based on its target environment, and if required, CENTERA uses an authentication scheme suitable for severely constrained nodes, ranging from the symmetric RC5 for safe environments under close administration, to pairing-based cryptography (PBC) for hostile environments with a strong attacker model. We simulate CENTERA using TOSSIM and verify its correctness and show some energy calculations. PMID:25648712

  2. CENTERA: a centralized trust-based efficient routing protocol with authentication for wireless sensor networks.

    PubMed

    Tajeddine, Ayman; Kayssi, Ayman; Chehab, Ali; Elhajj, Imad; Itani, Wassim

    2015-01-01

    In this paper, we present CENTERA, a CENtralized Trust-based Efficient Routing protocol with an appropriate authentication scheme for wireless sensor networks (WSN). CENTERA utilizes the more powerful base station (BS) to gather minimal neighbor trust information from nodes and calculate the best routes after isolating different types of "bad" nodes. By periodically accumulating these simple local observations and approximating the nodes' battery lives, the BS draws a global view of the network, calculates three quality metrics-maliciousness, cooperation, and compatibility-and evaluates the Data Trust and Forwarding Trust values of each node. Based on these metrics, the BS isolates "bad", "misbehaving" or malicious nodes for a certain period, and put some nodes on probation. CENTERA increases the node's bad/probation level with repeated "bad" behavior, and decreases it otherwise. Then it uses a very efficient method to distribute the routing information to "good" nodes. Based on its target environment, and if required, CENTERA uses an authentication scheme suitable for severely constrained nodes, ranging from the symmetric RC5 for safe environments under close administration, to pairing-based cryptography (PBC) for hostile environments with a strong attacker model. We simulate CENTERA using TOSSIM and verify its correctness and show some energy calculations. PMID:25648712

  3. Nonsurgical endodontic treatment of a maxillary lateral incisor with dens invaginatus type II: A case report

    PubMed Central

    Shadmehr, Elham; Kiaani, Sima; Mahdavian, Parinaz

    2015-01-01

    Dens invaginatus is a rare developmental anomaly of teeth with complex root canal system morphology. The present case describes a peg shape maxillary lateral incisor with dens invaginatus (Oehlers type II), necrotic pulp, and an associated large periradicular lesion. Nonsurgical endodontic treatment was performed with the aim of removing the blind sac with diamond bur under the use of operating surgical microscope. The root canal system was obturated with thermoplastic technique. Final restoration was done using composite. The 20-months clinical and radiological follow up revealed an asymptomatic tooth with healing of the periapical pathology; however, for complete healed periradicular lesion more follow up is needed. This case illustrated that a dens invaginatus malformed teeth with a large periradicular lesion can be managed successfully with nonsurgical root canal therapy (NSRCT). PMID:25878686

  4. The effects of spaceflight on the mineralization of rat incisor dentin

    NASA Technical Reports Server (NTRS)

    Simmons, D. J.; Rosenberg, G. D.

    1984-01-01

    Specific effects of space flight on dentin formation on the lower incisors of male rats were determined. Data were Fourier analyzed to determine the spectra of chemical growth rhythms. It was found that Calcium and P were more concentrated in the newly forming dentin of the Flight rats than in comparable regions of control tissues. There was no significant difference in the mean S-concentration between the two groups, but the pattern of S-distribution in the recently formed dentin from the Flight rats was different from that in the control group. Sulfur fluctuations in flight animals periodically peak above the irregular background fluctuations, but there are no comparable sulfur peaks across the dentin in the control. It is indicated that spaceflight has measurable effects on dentinogenesis, and may also bear on the problem of the regulatory role of proteoglycans in mineralization and the maturation of mineral and matrix moieties in skeletal tissue.

  5. Agenesis of maxillary lateral incisor in an Angle Class II, Division 1 malocclusion patient.

    PubMed

    Thiesen, Guilherme

    2015-10-01

    The present case report describes the orthodontic treatment of a patient with agenesis of maxillary left lateral incisor and Angle Class II, Division 1 malocclusion. The patient also presented with maxillary midline deviation and inclination of the occlusal plane in the anterior region. Treatment objectives were: correction of sagittal relationship between the maxilla and the mandible; correction of midline deviation, so as to cause maxillary and mandibular midlines to coincide; correction of overbite and leveling of the occlusal plane, so as to create ideal conditions for esthetic rehabilitation of anterior teeth. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:26560829

  6. Agenesis of maxillary lateral incisor in an Angle Class II, Division 1 malocclusion patient

    PubMed Central

    Thiesen, Guilherme

    2015-01-01

    The present case report describes the orthodontic treatment of a patient with agenesis of maxillary left lateral incisor and Angle Class II, Division 1 malocclusion. The patient also presented with maxillary midline deviation and inclination of the occlusal plane in the anterior region. Treatment objectives were: correction of sagittal relationship between the maxilla and the mandible; correction of midline deviation, so as to cause maxillary and mandibular midlines to coincide; correction of overbite and leveling of the occlusal plane, so as to create ideal conditions for esthetic rehabilitation of anterior teeth. This case was presented to the Brazilian Board of Orthodontics and Dentofacial Orthopedics (BBO) as a requirement for the title of certified by the BBO. PMID:26560829

  7. Palatogingival Groove: Recognizing and Managing the Hidden Tract in a Maxillary Incisor: A Case Report

    PubMed Central

    Sharma, Sarang; Deepak, Passi; Vivek, Sharma; Ranjan Dutta, Shubha

    2015-01-01

    Palatogingival grooves are developmental malformations quite notorious for precipitating endodontic - periodontal lesions. Owing to their inconspicuous occurrence, funnel-shaped morphology and variable extent on tooth root, they promote adherence of plaque and bacteria to levels significant for the development of pathology. Several treatment approaches have been recognized in literature for the management of this anomaly. Here in this report, a 25-year-old patient reported with the complaint of pain and swelling in maxillary right lateral incisor. Clinical examination confirmed an endodontic - periodontal lesion in relation to palatogingival groove. Endodontic treatment was instituted, followed by odontoplasty of the groove and restoration with newer calcium silicate cement, Biodentine. Combined endodontic - periodontal approach was successful in resolving the pathology with complete healing seen both clinically and radiographically. Timely diagnosis, prevention and management are highly recommended to prevent tooth loss due to complications arising secondary to their presence. PMID:26124612

  8. Very Large Inflammatory Odontogenic Cyst with Origin on a Single Long Time Traumatized Lower Incisor.

    PubMed

    Martins, Jorge N R; Freitas, Filipe; Andre, Saudade; Moreira, Andre; Carames, Joao

    2015-07-01

    One of the consequences of traumatic injuries is the chance of aseptic pulp necrosis to occur which in time may became infected and give origin to periapical pathosis. Although the apical granulomas and cysts are a common condition, there appearance as an extremely large radiolucent image is a rare finding. Differential diagnosis with other radiographic-like pathologies, such as keratocystic odontogenic tumour or unicystic ameloblastoma, is mandatory. The purpose of this paper is to report a very large radicular cyst caused by a single mandibular incisor traumatized long back, in a 60-year-old male. Medical and clinical histories were obtained, radiographic and cone beam CT examinations performed and an initial incisional biopsy was done. The final decision was to perform a surgical enucleation of a lesion, 51.4 mm in length. The enucleated tissue biopsy analysis was able to render the diagnosis as an inflammatory odontogenic cyst. A 2 year follow-up showed complete bone recovery. PMID:26393219

  9. Very Large Inflammatory Odontogenic Cyst with Origin on a Single Long Time Traumatized Lower Incisor

    PubMed Central

    Freitas, Filipe; Andre, Saudade; Moreira, Andre; Carames, Joao

    2015-01-01

    One of the consequences of traumatic injuries is the chance of aseptic pulp necrosis to occur which in time may became infected and give origin to periapical pathosis. Although the apical granulomas and cysts are a common condition, there appearance as an extremely large radiolucent image is a rare finding. Differential diagnosis with other radiographic-like pathologies, such as keratocystic odontogenic tumour or unicystic ameloblastoma, is mandatory. The purpose of this paper is to report a very large radicular cyst caused by a single mandibular incisor traumatized long back, in a 60-year-old male. Medical and clinical histories were obtained, radiographic and cone beam CT examinations performed and an initial incisional biopsy was done. The final decision was to perform a surgical enucleation of a lesion, 51.4 mm in length. The enucleated tissue biopsy analysis was able to render the diagnosis as an inflammatory odontogenic cyst. A 2 year follow-up showed complete bone recovery. PMID:26393219

  10. Comparison of Intrusion Effects on Maxillary Incisors Among Mini Implant Anchorage, J-Hook Headgear and Utility Arch

    PubMed Central

    Kumar, Sridhar Prem; Manjula, W.S.

    2014-01-01

    Background: Intrusion of maxillary incisors is one of the most important and difficult tooth movements to achieve as a part of orthodontic therapy. A variety of techniques were used in the past to intrude the maxillary incisors before the emergence of mini implants in Orthodontics. Mini implants are temporary anchorage devices used to produce various tooth movements. The research was carried out to evaluate and compare the efficiency of producing intrusion of maxillary incisors using mini implants, utility arch and j- hook headgear. Materials and Methods: The study was conducted on 30 subjects divided into 3 Groups equally. Group 1- mini implant anchorage, Group 2 - j- hooks headgear and Group 3- utility arch were used for intrusion of the maxillary incisors. Conventional lateral cephalograms were taken before treatment and at the end of intrusion. Five cephalometric parameters were used to measure the amount of intrusion attained in each Group. Intra Group comparisons were done using student t-test and inter Group comparisons were done using ANOVA The duration of intrusion was four months in all the three Groups. Results: In Group 1 the mean average intrusion attained was 2.1 mm, the mean average intrusion attained in Group 2 was 0.7 mm, and the mean average intrusion achieved in Group 3 was 1.4 mm with a side effect of 0.75 mm of molar extrusion. Conclusion: Although, both mini implants and utility arch can be used to attain significant amounts of incisor intrusion but using mini implants will produce true intrusion without any other side effects. PMID:25177631

  11. X-ray microtomographic study of mineral distribution in enamel of mandibular rat incisors.

    PubMed

    Wong, F S; Elliott, J C; Davis, G R; Anderson, P

    2000-04-01

    X-ray microtomography was used to study the mineral concentrations in sequential slices of enamel of 5 mandibular incisors which showed an increase from approximately 1.0 to approximately 2.7 g cm(-3) from the apex towards the incisal end. For points at the same distance from the apex, there were differences up to 0.6 g cm(-3) between the teeth. The change of mean concentrations in the slices with distance could be modelled as (different) saturating exponentials. Under the assumption of a uniform growth rate of a mandibular incisor of 0.6 mm per day and a common time origin for the start of maturation (taken as a mineral concentration of 1 g cm(-3)), the distances were transformed to a common time frame to give a pooled data set. A single saturating exponential could be fitted to this pooled transformed data; this was: Cm = 2.84-1.94exp (-0.18d) where Cm is the mean mineral concentration (g cm(-3)) and d the time (days) from the start of maturation. This gives an asymptotic concentration of 2.84 g cm(-3) towards the incisal end, with a time constant of 7.7 days. The mineral concentration distribution functions were found to be more positively skewed closer to the apex, but more negatively skewed towards the incisal end. The difference between the higher mineral concentration in the outer enamel and the enamel near the amelodentinal junction (ADJ) was approximately 3%. The direction of maximum increase in concentration from the outer enamel surface to the ADJ meets the boundary of the ADJ at approximately 80 degrees. Three dimensional surface rendering of isodensity contours showed that the previously described C-shaped pattern of mineralisation is not solely a surface phenomenon, but extends through the depth of the enamel. PMID:10853962

  12. Assessment of association between molar incisor hypomineralization and hypomineralized second primary molar

    PubMed Central

    Mittal, Rakesh; Chandak, Shweta; Chandwani, Manisha; Singh, Prabhat; Pimpale, Jitesh

    2016-01-01

    Background: The term molar incisor hypomineralization (MIH) has been described as a clinical entity of systemic origin affecting the enamel of one or all first permanent molars and also the incisors; less frequently the second primary molars have also been reported to develop hypomineralization of the enamel, along with MIH. Aim: To scrutinize the association between hypomineralized second primary molars (HSPMs) and MIH and their prevalence in schoolgoing pupils in Nagpur, Maharashtra, India and the associated severity of dental caries. Design: A sample of 1,109 pupils belonging to 3–12-year-old age group was included. The entire sample was then divided into Group I (3–5 years) and Group II (6–12 years). The scoring criteria proposed by the European Academy of Pediatric Dentistry for hypomineralization was used to score HSPM and MIH. The International Caries Detection and Assessment System II (ICDAS II) was used for appraising caries status in the hypomineralized molars. The examination was conducted by a single calibrated dentist in schools in daylight. The results, thus obtained, were statistically analyzed using Chi-square test and odds ratio. Result: Of the children examined, 10 in Group I (4.88%) had HSPM and 63 in Group II (7.11%) had MIH in at least one molar. In Group II, out of 63 subjects diagnosed with MIH, 30 subjects (48%) also had HSPM. Carious lesions with high severity were appreciated in hypomineralized molars. Conclusion: The prevalence of HSPM was 4.88% and of MIH was 7.11%. Approximately half of the affected first permanent molars were associated with HSPM. The likelihood of development of caries increased with the severity of hypomineralization defect. PMID:27011930

  13. Branch-Based Centralized Data Collection for Smart Grids Using Wireless Sensor Networks

    PubMed Central

    Kim, Kwangsoo; Jin, Seong-il

    2015-01-01

    A smart grid is one of the most important applications in smart cities. In a smart grid, a smart meter acts as a sensor node in a sensor network, and a central device collects power usage from every smart meter. This paper focuses on a centralized data collection problem of how to collect every power usage from every meter without collisions in an environment in which the time synchronization among smart meters is not guaranteed. To solve the problem, we divide a tree that a sensor network constructs into several branches. A conflict-free query schedule is generated based on the branches. Each power usage is collected according to the schedule. The proposed method has important features: shortening query processing time and avoiding collisions between a query and query responses. We evaluate this method using the ns-2 simulator. The experimental results show that this method can achieve both collision avoidance and fast query processing at the same time. The success rate of data collection at a sink node executing this method is 100%. Its running time is about 35 percent faster than that of the round-robin method, and its memory size is reduced to about 10% of that of the depth-first search method. PMID:26007734

  14. Branch-based centralized data collection for smart grids using wireless sensor networks.

    PubMed

    Kim, Kwangsoo; Jin, Seong-il

    2015-01-01

    A smart grid is one of the most important applications in smart cities. In a smart grid, a smart meter acts as a sensor node in a sensor network, and a central device collects power usage from every smart meter. This paper focuses on a centralized data collection problem of how to collect every power usage from every meter without collisions in an environment in which the time synchronization among smart meters is not guaranteed. To solve the problem, we divide a tree that a sensor network constructs into several branches. A conflict-free query schedule is generated based on the branches. Each power usage is collected according to the schedule. The proposed method has important features: shortening query processing time and avoiding collisions between a query and query responses. We evaluate this method using the ns-2 simulator. The experimental results show that this method can achieve both collision avoidance and fast query processing at the same time. The success rate of data collection at a sink node executing this method is 100%. Its running time is about 35 percent faster than that of the round-robin method, and its memory size is reduced to about 10% of that of the depth-first search method. PMID:26007734

  15. Efficient crop type mapping based on remote sensing in the Central Valley, California

    NASA Astrophysics Data System (ADS)

    Zhong, Liheng

    Most agricultural systems in California's Central Valley are purposely flexible and intentionally designed to meet the demands of dynamic markets. Agricultural land use is also impacted by climate change and urban development. As a result, crops change annually and semiannually, which makes estimating agricultural water use difficult, especially given the existing method by which agricultural land use is identified and mapped. A minor portion of agricultural land is surveyed annually for land-use type, and every 5 to 8 years the entire valley is completely evaluated. So far no effort has been made to effectively and efficiently identify specific crop types on an annual basis in this area. The potential of satellite imagery to map agricultural land cover and estimate water usage in the Central Valley is explored. Efforts are made to minimize the cost and reduce the time of production during the mapping process. The land use change analysis shows that a remote sensing based mapping method is the only means to map the frequent change of major crop types. The traditional maximum likelihood classification approach is first utilized to map crop types to test the classification capacity of existing algorithms. High accuracy is achieved with sufficient ground truth data for training, and crop maps of moderate quality can be timely produced to facilitate a near-real-time water use estimate. However, the large set of ground truth data required by this method results in high costs in data collection. It is difficult to reduce the cost because a trained classification algorithm is not transferable between different years or different regions. A phenology based classification (PBC) approach is developed which extracts phenological metrics from annual vegetation index profiles and identifies crop types based on these metrics using decision trees. According to the comparison with traditional maximum likelihood classification, this phenology-based approach shows great advantages when the size of the training set is limited by ground truth availability. Once developed, the classifier is able to be applied to different years and a vast area with only a few adjustments according to local agricultural and annual weather conditions. 250 m MODIS imagery is utilized as the main input to the PBC algorithm and displays promising capacity in crop identification in several counties in the Central Valley. A time series of Landsat TM/ETM+ images at a 30 m resolution is necessary in the crop mapping of counties with smaller land parcels, although the processing time is longer. Spectral characteristics are also employed to identify crops in PBC. Spectral signatures are associated with phenological stages instead of imaging dates, which highly increases the stability of the classifier performance and overcomes the problem of over-fitting. Moderate accuracies are achieved by PBC, with confusions mostly within the same crop categories. Based on a quantitative analysis, misclassification in PBC has very trivial impacts on the accuracy of agricultural water use estimate. The cost of the entire PBC procedure is controlled to a very low level, which will enable its usage in routine annual crop mapping in the Central Valley.

  16. Spatial and seasonal variability of base flow in the Verde Valley, central Arizona, 2007 and 2011

    USGS Publications Warehouse

    Garner, Bradley D.; Bills, Donald J.

    2012-01-01

    Synoptic base-flow surveys were conducted on streams in the Verde Valley, central Arizona, in June 2007 and February 2011 by the U.S. Geological Survey (USGS), in cooperation with the Verde River Basin Partnership, the Town of Clarkdale, and Yavapai County. These surveys, also known as seepage runs, measured streamflow under base-flow conditions at many locations over a short period of time. Surveys were conducted on a segment of the Verde River that flows through the Verde Valley, between USGS streamflow-gaging stations 09504000 and 09506000, a distance of 51 river miles. Data from the surveys were used to investigate the dominant controls on Verde River base flow, spatial variability in gaining and losing reaches, and the effects that human alterations have on base flow in the surface-water system. The most prominent human alterations in the Verde Valley are dozens of surface-water diversions from streams, including gravity-fed ditch diversions along the Verde River.Base flow that entered the Verde River from the tributary streams of Oak Creek, Beaver Creek, and West Clear Creek was found to be a major source of base flow in the Verde River. Groundwater discharge directly into the Verde River near these three confluences also was an important contributor of base flow to the Verde River, particularly near the confluence with Beaver Creek. An examination of individual reaches of the Verde River in the Verde Valley found three reaches (largely unaffected by ditch diversions) exhibiting a similar pattern: a small net groundwater discharge in February 2011 (12 cubic feet per second or less) and a small net streamflow loss in June 2007 (11 cubic feet per second or less). Two reaches heavily affected by ditch diversions were difficult to interpret because of the large number of confounding human factors. Possible lower and upper bounds of net groundwater flux were calculated for all reaches, including those heavily affected by ditches.

  17. [Study on the control of dynamic artificial limb ankle based on central pattern generator].

    PubMed

    Guo, Xin; Xu, Caiyu; Li, Mingyue; Su, Longtao

    2014-12-01

    In order to obtain the normal gait for the prosthesis-carrier with the change of external environment and gait, we designed a model of dynamic ankle prosthesis and control system and introduced the strategy of central pattern generator (CPG) about the moving trail of dynamic ankle prosthesis. The dynamic parts, which are incorporated in the model of dynamic ankle prosthesis, provide power in order to have anthropic function and character. The tool of Matlab/simulink was used to simulate the strategy. The simulation results showed that the strategy of CPG learn- ing control in this study was effective and could track the reference trail rapidly and fit the moving trail of a person's normal limb. It can make the prosthetic timely regulation and action, enhance the prosthetic intelligence. It has im- portant practical value for intelligent prosthesis development based on this analysis of technology. PMID:25868262

  18. The Exchange Data Communication System based on Centralized Database for the Meat Industry

    NASA Astrophysics Data System (ADS)

    Kobayashi, Yuichi; Taniguchi, Yoji; Terada, Shuji; Komoda, Norihisa

    We propose applying the EDI system that is based on centralized database and supports conversion of code data to the meat industry. This system makes it possible to share exchange data on beef between enterprises from producers to retailers by using Web EDI technology. In order to efficiently convert code direct conversion of a sender's code to a receiver's code using a code map is used. This system that mounted this function has been implemented in September 2004. Twelve enterprises including retailers, and processing traders, and wholesalers were using the system as of June 2005. In this system, the number of code maps relevant to the introductory cost of the code conversion function was lower than the theoretical value and were close to the case that a standard code is mediated.

  19. [The Development of Information Centralization and Management Integration System for Monitors Based on Wireless Sensor Network].

    PubMed

    Xu, Xiu; Zhang, Honglei; Li, Yiming; Li, Bin

    2015-07-01

    Developed the information centralization and management integration system for monitors of different brands and models with wireless sensor network technologies such as wireless location and wireless communication, based on the existing wireless network. With adaptive implementation and low cost, the system which possesses the advantages of real-time, efficiency and elaboration is able to collect status and data of the monitors, locate the monitors, and provide services with web server, video server and locating server via local network. Using an intranet computer, the clinical and device management staffs can access the status and parameters of monitors. Applications of this system provide convenience and save human resource for clinical departments, as well as promote the efficiency, accuracy and elaboration for the device management. The successful achievement of this system provides solution for integrated and elaborated management of the mobile devices including ventilator and infusion pump. PMID:26665944

  20. Measuring Long-Term Impact Based on Network Centrality: Unraveling Cinematic Citations

    PubMed Central

    Spitz, Andreas; Horvát, Emőke-Ágnes

    2014-01-01

    Traditional measures of success for film, such as box-office revenue and critical acclaim, lack the ability to quantify long-lasting impact and depend on factors that are largely external to the craft itself. With the growing number of films that are being created and large-scale data becoming available through crowd-sourced online platforms, an endogenous measure of success that is not reliant on manual appraisal is of increasing importance. In this article we propose such a ranking method based on a combination of centrality indices. We apply the method to a network that contains several types of citations between more than 40,000 international feature films. From this network we derive a list of milestone films, which can be considered to constitute the foundations of cinema. In a comparison to various existing lists of ‘greatest’ films, such as personal favourite lists, voting lists, lists of individual experts, and lists deduced from expert polls, the selection of milestone films is more diverse in terms of genres, actors, and main creators. Our results shed light on the potential of a systematic quantitative investigation based on cinematic influences in identifying the most inspiring creations in world cinema. In a broader perspective, we introduce a novel research question to large-scale citation analysis, one of the most intriguing topics that have been at the forefront of scientific enquiries for the past fifty years and have led to the development of various network analytic methods. In doing so, we transfer widely studied approaches from citation analysis to the the newly emerging field of quantification efforts in the arts. The specific contribution of this paper consists in modelling the multidimensional cinematic references as a growing multiplex network and in developing a methodology for the identification of central films in this network. PMID:25295877

  1. Situational Lightning Climatologies for Central Florida: Phase IV: Central Florida Flow Regime Based Climatologies of Lightning Probabilities

    NASA Technical Reports Server (NTRS)

    Bauman, William H., III

    2009-01-01

    The threat of lightning is a daily concern during the warm season in Florida. Research has revealed distinct spatial and temporal distributions of lightning occurrence that are strongly influenced by large-scale atmospheric flow regimes. Previously, the Applied Meteorology Unit (AMU) calculated the gridded lightning climatologies based on seven flow regimes over Florida for 1-, 3- and 6-hr intervals in 5-, 10-, 20-, and 30-NM diameter range rings around the Shuttle Landing Facility (SLF) and eight other airfields in the National Weather Service in Melbourne (NWS MLB) county warning area (CWA). In this update to the work, the AMU recalculated the lightning climatologies for using individual lightning strike data to improve the accuracy of the climatologies. The AMU included all data regardless of flow regime as one of the stratifications, added monthly stratifications, added three years of data to the period of record and used modified flow regimes based work from the AMU's Objective Lightning Probability Forecast Tool, Phase II. The AMU made changes so the 5- and 10-NM radius range rings are consistent with the aviation forecast requirements at NWS MLB, while the 20- and 30-NM radius range rings at the SLF assist the Spaceflight Meteorology Group in making forecasts for weather Flight Rule violations during Shuttle landings. The AMU also updated the graphical user interface with the new data.

  2. Estimation of Vulnerability of Coastal Regions Using the Central Pressure of Typhoon Based on Global Climate Change

    NASA Astrophysics Data System (ADS)

    Hashimura, R.

    2014-12-01

    Typhoons strike the Kyushu Island in the west of Japan a few times a year. Damage of the maritime structures by storm surges and wind waves induced by typhoon frequently occurs in the western prefectures, for example, Kumamoto Prefecture. The coastline in this prefecture is complex. It faces open and closed seas. The coastline is divided into 4 coastal regions in this paper. Each coast has different topographical characteristics. Using data on the damage of maritime structures caused by typhoons during past 25 years from 1980 to 2004 and the path and central pressure of typhoons during past 110 years from 1902 to 2011, damage of 4 regions along the coast line of Kumamoto Prefecture in Japan for 13 groups of typhoon with different paths is estimated. All typhoons had passed through an area delineated by a latitude of 30 N and 35 N and at a longitude of 127 E and 132 E. The improved Central Pressure (iCP) Method can be used to estimate the damage of maritime structures that will occur along the coast before typhoon strikes. The improved Central Pressure Method is developed based on the 25 years from 1980 to 2004. The estimation of the damage is done using the central pressure of typhoon at a latitude of 30 N. To develop the central pressure method considering the influence of global warming, the data of the central pressure of typhoons based on the 100 years more term is needed. The trend of the depression of central pressure due to the global warming is discussed using the central pressure based on the 110 years term typhoon data. Furthermore, the risk of each coastal regions in a future is estimated using the increasing or decreasing value of central pressure which is determined on this period data.

  3. Studying Geology of Central Texas through Web-Based Virtual Field Trips

    NASA Astrophysics Data System (ADS)

    Chan, C.; Khan, S. D.; Wellner, J. S.

    2007-12-01

    Each year over 2500 students, mainly non-science majors, take introductory geology classes at the University of Houston. Optional field trips to Central Texas for these classes provide a unique learning opportunity for students to experience geologic concepts in a real world context. The field trips visit Enchanted Rock, Inks Lake, Bee Cave Road, Lion Mountain, and Slaughter Gap. Unfortunately, only around 10% of our students participate in these field trips. We are developing a web-based virtual field trip for Central Texas to provide an additional effective learning experience for students in these classes. The module for Enchanted Rock is complete and consists of linked geological maps, satellite imagery, digital elevation models, 3-D photography, digital video, and 3-D virtual reality visualizations. The ten virtual stops focus on different geologic process and are accompanied by questions and answers. To test the efficacy of the virtual field trip, we developed a quiz to measure student learning and a survey to evaluate the website. The quiz consists of 10 questions paralleling each stop and information on student attendance on the Central Texas field trip and/or the virtual field trip. From the survey, the average time spent on the website was 26 minutes, and overall the ratings of the virtual field trip were positive. Most noticeably students responded that the information on the website was relevant to their class and that the pictures, figures, and animations were essential to the website. Although high correlation coefficients between responses were expected for some questions (i.e., 0.89 for "The content or text of the website was clear" and "The information on the website was easy to read"), some correlations were less expected: 0.77 for "The number of test questions was appropriate" and "The information on the website was easy to read," and 0.70 for "The test questions reinforced the material presented on the website" and "The information on the website is relevant to my class." These virtual field trips provide an alternative for students who cannot attend the actual field trips. They also allow transfer students to experience these sites before attending upper level field trips, which often return to study these sites in more detail. These modules provide a valuable supplementary experience for all students, as they emphasize skills for which we are presently unable to provide sufficient practice in lecture, fieldtrips, or laboratory. Public access to the field trips is available at: http://geoinfo.geosc.uh.edu/VR/

  4. Characteristics and composition of atmospheric aerosols in Phimai, central Thailand during BASE-ASIA

    NASA Astrophysics Data System (ADS)

    Li, Can; Tsay, Si-Chee; Hsu, N. Christina; Kim, Jin Young; Howell, Steven G.; Huebert, Barry J.; Ji, Qiang; Jeong, Myeong-Jae; Wang, Sheng-Hsiang; Hansell, Richard A.; Bell, Shaun W.

    2013-10-01

    Comprehensive measurements of atmospheric aerosols were made in Phimai, central Thailand (15.183N, 102.565E, elevation: 206 m) during the BASE-ASIA field experiment from late February to early May in 2006. The observed aerosol loading was sizable for this rural site (mean aerosol scattering: 108 64 Mm-1; absorption: 15 8 Mm-1; PM10 concentration: 33 17 ?g m-3), and dominated by submicron particles. Major aerosol compounds included carbonaceous (OC: 9.5 3.6 ?g m-3; EC: 2.0 2.3 ?g m-3) and secondary species (SO42-: 6.4 3.7 ?g m-3, NH4+: 2.2 1.3 ?g m-3). While the site was seldom under the direct influence of large forest fires to its north, agricultural fires were ubiquitous during the experiment, as suggested by the substantial concentration of K+ (0.56 0.33 ?g m-3). Besides biomass burning, aerosols in Phimai during the experiment were also strongly influenced by industrial and vehicular emissions from the Bangkok metropolitan region and long-range transport from southern China. High humidity played an important role in determining the aerosol composition and properties in the region. Sulfate was primarily formed via aqueous phase reactions, and hygroscopic growth could enhance the aerosol light scattering by up to 60%, at the typical morning RH level of 85%. The aerosol single scattering albedo demonstrated distinct diurnal variation, ranging from 0.86 0.04 in the evening to 0.92 0.02 in the morning. This experiment marks the first time such comprehensive characterization of aerosols was made for rural central Thailand. Our results indicate that aerosol pollution has developed into a regional problem for northern Indochina, and may become more severe as the region's population and economy continue to grow.

  5. Assessing the ecological base flow in an experimental watershed of Central Taiwan

    NASA Astrophysics Data System (ADS)

    Wei, Chiang; Yang, Ping-Shih; Tian, Pei-Ling

    2010-05-01

    The ecological base flow is crucial for the assessment and design for habitat rehabilitation and recovery. The amount of discharge affects the aquatic creatures and may damage the existence and balance of the community under extreme low conditions. Aquatic insect is selected as the target species in this study to evaluate the influence of the discharge and to estimate the ecological base flow. The distribution of the number of species and abundance (density) versus discharge is assessed to define the critical discharge. A stream located at the alpine area in central Taiwan is selected as the study area to evaluate the base flow. From the preliminary data (Aug 2008 to May 2009) collected from Creek C of Sitou watershed (area: 1.3 km^2) shows that the abundance of several species varies with the discharge. The dominate family and genus of aquatic insects is Baetidae (Order Ephemeroptera) and Baetis spp. that accounts for 26.3 and 17.2 %, respectively. The Hilsenhoff family biotic index (FBI) shows that the water quality is classified to "Excellent" and "Good" level while the EPT Index (Index of three orders: Ephemeroptera, Plecoptera, and Trichoptera) indicates that the stream is non-polluted. The discharge of base flow interpreted from the 90%, 95% and 96% curve of duration for the daily discharge is 0.1582, 0.0476 and 0.0378 cms; the threshold value evaluated by curve of abundance vs. discharge is 0.0154 cms. Consistent observations are yet to be collected to yield more accurate results.

  6. A centralized, computerized, and relational data base for student clinical placements.

    PubMed

    Lears, M K; Olsen, S J; Morrison, C; Vessey, J A

    1998-01-01

    Quality clinical experiences are a critical component of advanced practice nursing (APN) curricula. Historically, nursing instructors coordinated both the didactic and clinical components of a course. Increasingly, course coordinators organize the didactic component, and external preceptors working in the clinical setting function as practicum teachers. Both scenarios involve labor-intensive processes, and neither facilitate the scheduling of clinical experiences that build on progressive learning across the student's curriculum. A centralized, computerized, relational data base for efficient management of APN preceptors and students across the curriculum was designed. One master's-prepared clinical coordinator maintains the data base and performs all related functions. This system offers numerous benefits to students, preceptors, ] faculty, and nursing school, including balanced and progressively complex clinical learning experiences for students from competent preceptors: consistent interface with students and preceptors; faculty relief from time-consuming tasks; rapid generation of a variety of tables, rosters, and reports; consistent tracking of preceptor evaluations; timely acknowledgment of preceptor assistance; and efficient communication among students, preceptors, faculty, and school administration. PMID:9549212

  7. Slow Vertical Downwasting of Cold-Based Ice Sheets in the Rondane Area, Central Scandinavia

    NASA Astrophysics Data System (ADS)

    Dahl, S.; Linge, H.; Fabel, D.; Murray, A.

    2007-12-01

    The rate of ice-sheet downwasting following the Late Weichselian glacial maximum (LGM) c. 20 ka is crucial for estimating the vertical extent prior to and during the last deglaciation in central Scandinavia. The Scandinavian Ice Sheet was cold-based in this region, and air temperature is suggested to be the critical factor influencing the rate of downwasting until the final deglaciation took place close to 10 ka. Depending on when the deglaciation started, the rate of downwasting necessary to explain recent 'maximum' and 'minimum' estimates for ice-sheet thickness may differ by 1-2 orders of magnitude. Here we present figures for the rate of downwasting based on OSL-dated waterlain sediments exposed to daylight prior to deposition and 10Be exposure dates on erratic boulders and lateral meltwater channels cut into bedrock in different altitudes. The results indicate a very slow vertical downwasting until c. 15 ka, and a somewhat increase prior to c. 13 ka. After a stillstand related to the Younger Dryas (12.8-11.5 ka) the downwasting accelerated until all ice was gone close to 10 ka. The ice-sheet surface was locally lowered c. 120 m from the LGM to 13.8 ka, or about 2.4 cm/year on an average. The results imply that a much thinner continental ice sheet that hitherto suggested by ice-sheet modelling is necessary to explain field observations related to the last deglaciation in the Rondane area.

  8. Central Retinal Vein Occlusion: A Review of Current Evidence-based Treatment Options

    PubMed Central

    Patel, Amy; Nguyen, Christine; Lu, Stephanie

    2016-01-01

    A central retinal vein occlusion (CRVO) can induce an ischemic and hypoxic state with resulting sequelae of macular edema and neovascularization. Many treatment options have been studied. Our review aims to investigate the safety and efficacy of the multiple treatment options of CRVO. A PubMed and Cochrane literature search was performed. Well-controlled randomized clinical trials that demonstrated strong level 1 evidence-based on the rating scale developed by the British Centre for Evidence-Based Medicine were included. Seven clinical trials met inclusion criteria to be included in this review. These included studies that investigated the safety and efficacy of retinal photocoagulation (1 study), intravitreal steroid treatment (2 studies), and antivascular endothelial growth factor treatment (4 studies) for the treatment of CRVO. In addition, studies evaluating surgical treatment options for CRVO were also included. Many treatment modalities have been demonstrated to be safe and efficacious in the treatment of CRVO. These treatment options offer therapeutic benefits for patients and clinically superior visual acuity and perhaps the quality of life after suffering from a CRVO. PMID:26957838

  9. Precipitation frequency analysis based on regional climate simulations in Central Alberta

    NASA Astrophysics Data System (ADS)

    Kuo, Chun-Chao; Gan, Thian Yew; Hanrahan, Janel L.

    2014-03-01

    A Regional Climate Model (RCM), MM5 (the Fifth Generation Pennsylvania State University/National Center for Atmospheric Research mesoscale model), is used to simulate summer precipitation in Central Alberta. MM5 was set up with a one-way, three-domain nested framework, with domain resolutions of 27, 9, and 3 km, respectively, and forced with ERA-Interim reanalysis data of ECMWF (European Centre for Medium-Range Weather Forecasts). The objective is to develop high resolution, grid-based Intensity-Duration-Frequency (IDF) curves based on the simulated annual maximums of precipitation (AMP) data for durations ranging from 15-min to 24-h. The performance of MM5 was assessed in terms of simulated rainfall intensity, precipitable water, and 2-m air temperature. Next, the grid-based IDF curves derived from MM5 were compared to IDF curves derived from six RCMs of the North American Regional Climate Change Assessment Program (NARCCAP) set up with 50-km grids, driven with NCEP-DOE (National Centers for Environmental Prediction-Department of Energy) Reanalysis II data, and regional IDF curves derived from observed rain gauge data (RG-IDF). The analyzed results indicate that 6-h simulated precipitable water and 2-m temperature agree well with the ERA-Interim reanalysis data. However, compared to RG-IDF curves, IDF curves based on simulated precipitation data of MM5 are overestimated especially for IDF curves of 2-year return period. In contract, IDF curves developed from NARCCAP data suffer from under-estimation and differ more from RG-IDF curves than the MM5 IDF curves. The over-estimation of IDF curves of MM5 was corrected by a quantile-based, bias correction method. By dynamically downscale the ERA-Interim and after bias correction, it is possible to develop IDF curves useful for regions with limited or no rain gauge data. This estimation process can be further extended to predict future grid-based IDF curves subjected to possible climate change impacts based on climate change projections of GCMs (general circulation models) of IPCC (Intergovernmental Panel on Climate Change).

  10. Characteristics and Composition of Atmospheric Aerosols in Phimai, Central Thailand During BASE-ASIA

    NASA Technical Reports Server (NTRS)

    Li, Can; Tsay, Si-Chee; Hsu, N. Christina; Kim, Jin Young; Howell, Steven G.; Huebert, Barry J.; Ji, Qiang; Jeong, Myeong-Jae; Wang, Sheng-Hsiang; Hansell, Richard A.; Bell, Shaun W.

    2012-01-01

    Popular summary: Atmospheric aerosols play an important role in the Earth's climate system, and can also have adverse effects on air quality and human health. The environmental impacts of aerosols, on the other hand, are highly regional, since their temporal/spatial distribution is inhomogeneous and highly depends on the regional emission sources. To better understand the effects of aerosols, intensive field experiments are necessary to characterize the chemical and physical properties on a region-by-region basis. From late February to early May in 2006, NASA/GSFC's SMARTLabs facility was deployed at a rural site in central Thailand, Southeast Asia, to conduct a field experiment dubbed BASE-ASIA (Biomass-burning Aerosols in South East-Asia: Smoke Impact Assessment). The group was joined by scientists from the University of Hawaii and other regional institutes. Comprehensive measurements were made during the experiment, including aerosol chemical composition, optical and microphysical properties, as well as surface energetics and local . meteorology. This study analyzes part of the data from the BASE-ASIA experiment. It was found that, even for the relatively remote rural site, the aerosol loading was still substantial. Besides agricultural burning in the area, industrial pollution near the Bangkok metropolitan area, about 200 km southeast of the site, and even long-range transport from China, also contribute to the area's aerosol loading. The results indicate that aerosol pollution has developed into a regional problem for northern Indochina, and may become more severe as the region's population and economy continue to grow. Abstract: Comprehensive measurements of atmospheric aerosols were made in Phimai, central Thailand (15.l83 N, 102.565 E, elevation: 206 m) during the BASE-ASIA field experiment from late February to early May in 2006. The observed aerosol loading was sizable for this rural site (mean aerosol scattering: 108 +/- 64 Mm(exp -1); absorption: 15 +/- 8 Mm(exp -1); PM(sub 10) concentration: 33 +/- 17 miro-g/ cubic m and dominated by submicron particles. Major aerosol compounds included carbonaceous (OC: 9.5 +/- 3.6miro-g/ cubic m; EC: 2.0 2.3 miro-g/ cubic m and secondary species (SO4(2-): 6.4 +/- 3.7 miro-g/ cubic m, NH4(+): 2.2 +/- 1.3 miro-g/ cubic m). While the site was seldom under the direct influence of large forest fires to its north, agricultural fires were ubiquitous during the experiment, as suggested by the substantial concentration of K+ (0.56 +/- 0.33 micro-g/ cubic m). Besides biomass burning, aerosols in Phimai during the experiment were also strongly influenced by industrial and vehicular emissions from the Bangkok metropolitan region and long-range transport from southern China. High humidity played an important role in determining the aerosol composition and properties in the region. Sulfate was primarily formed via aqueous phase reactions, and hygroscopic growth could enhance the aerosol light scattering by up to 60%, at the typical morning RH level of 85%. The aerosol single scattering albedo demonstrated distinct diurnal variation, ranging from 0.86 +/- 0.04 in the evening to 0.92 +/- 0.02 in the morning. This experiment marks the first time such comprehensive characterization of aerosols was made for rural central Thailand. Our results indicate that aerosol pollution has developed into a regional problem for northern Indochina, and may become more severe as the region's population and economy continue to grow.

  11. Double talon cusps on supernumerary tooth fused to maxillary central incisor: Review of literature and report of case

    PubMed Central

    2014-01-01

    Human tooth development is a continuous process begin at the sixth weeks in utero and extends to about sixth months after birth for the primary dentition and from sixteenth week in utero to late adolescence for permanent dentition. There is no other organ of the human body which takes so long to attain its ultimate morphology as dentition. Several physiologic growth processes participate in the progressive development of the teeth including: initiation, proliferation, histodifferentiation, morphodifferentiation, apposition, calcification, and eruption. Aberrations in different stages of tooth development can result in unique manifestations both in primary and permanent dentitions. The fact that premaxilla is the predilection site for the occurrence of supernumerary teeth, talon cusp, dens invaginatus, and geminated teeth may suggest that the embryological development of premaxilla differ from other sites of the jaws. The dental abnormalities presented in this review are of great concern to dentist and parents because they create clinical, pathological and esthetic problems. Dental practitioner should be aware of the clinical sign, associated problems and treatment options for a given case. Key words:Double talon cusps, fusion, supernumerary, case report. PMID:25593664

  12. Retrieval of Iatrogenically Pushed Pulp Stone From Middle Third of Root Canal in Permanent Maxillary Central Incisor: A Case Report

    PubMed Central

    Juneja, Suruchi; Randhawa, Sohajpreet; Dhebar, Tejal Malay; Raheja, Anupama

    2015-01-01

    The pulp stones are the discrete nodular calcified masses commonly existing in coronal and occasionally in radicular pulp, placed freely, attached or embedded into the dentine. The present case report revealed the iatrogenic pushing of pulp stone and blockage of root canal that caused endodontic failure. The case enlightens the proper use of ultrasonic instruments with irrigating solutions to manage the calcifications in root canal for successful endodontic therapy. PMID:26266224

  13. Autotransplantation combined with orthodontic treatment: a case involving the maxillary central incisors with root resorption after traumatic injury

    PubMed Central

    Ferreira, Hugo M.; Botelho, Filomena; Carrilho, Eunice

    2015-01-01

    Traumatic dental injury can result in avulsion of anterior teeth. In young patients, it is a challenge to the dental professional because after replantation, late complications such as ankylosis require tooth extraction. Although prosthetic and orthodontic treatment, and implant placement have been described as the options for intervention, autogenous tooth transplantation could be an effective procedure in growing patients if there is a suitable donor tooth available. This case presents the treatment of a patient who suffered a traumatic injury at 9 years old with avulsion of tooth 21, which had been replanted, and intrusion of tooth 11. Both teeth ankylosed; thus they were removed and autotransplantation of premolars was carried out. After transplantation, the tooth underwent root canal treatment because of pulpal necrosis. Orthodontic treatment began 3 months after transplantation and during 7 years' follow-up the aesthetics and function were maintained without signs of resorption. PMID:26295028

  14. Status and future transition of rapid urbanizing landscape in central Western Ghats - CA based approach

    NASA Astrophysics Data System (ADS)

    Bharath, S..; Rajan, K. S.; Ramachandra, T. V.

    2014-11-01

    The land use changes in forested landscape are highly complex and dynamic, affected by the natural, socio-economic, cultural, political and other factors. The remote sensing (RS) and geographical information system (GIS) techniques coupled with multi-criteria evaluation functions such as Markov-cellular automata (CA-Markov) model helps in analysing intensity, extent and future forecasting of human activities affecting the terrestrial biosphere. Karwar taluk of Central Western Ghats in Karnataka state, India has seen rapid transitions in its forest cover due to various anthropogenic activities, primarily driven by major industrial activities. A study based on Landsat and IRS derived data along with CA-Markov method has helped in characterizing the patterns and trends of land use changes over a period of 2004-2013, expected transitions was predicted for a set of scenarios through 2013-2022. The analysis reveals the loss of pristine forest cover from 75.51% to 67.36% (1973 to 2013) and increase in agriculture land as well as built-up area of 8.65% (2013), causing impact on local flora and fauna. The other factors driving these changes are the aggregated level of demand for land, local and regional effects of land use activities such as deforestation, improper practices in expansion of agriculture and infrastructure development, deteriorating natural resources availability. The spatio temporal models helped in visualizing on-going changes apart from prediction of likely changes. The CA-Markov based analysis provides us insights into the localized changes impacting these regions and can be useful in developing appropriate mitigation management approaches based on the modelled future impacts. This necessitates immediate measures for minimizing the future impacts.

  15. Structural analysis of the central Columbia Plateau utilizing radar, digital topography, and magnetic data bases

    SciTech Connect

    Thiessen, R.L.; Eliason, J.R.; Johnson, L.K.; Brougher, C.W.; Foley, M.G.; Beaver, D.E.

    1988-01-01

    The geology of the central Columbia Plateau is characterized by subdued topography and limited outcrop, with most of the exposure concentrated in localized folded/faulted mountains (the Yakima folds) and along river canyons. In order to efficiently compare lineament data bases, we have written an automated computer routine that correlates lineaments that are within a user specified distance of each other. The angle between their trends has to be less than an input maximum separation angle. If more than two lineament maps exist for the area, the analyst may also specify the minimum number of times each structure must be seen. The lineament correlation routine was applied to data bases of all aeromagnetic linears as well as lineaments seen on radar and a digital elevation model image. Due to their topographic expression and associated deformation, the Yakima folds are detected by nearly all of the studies. Other features that do not correspond to known structures are detected in a number of the above data types and so are likely to have a strong structural control. Previously mapped small faults that obliquely cross the Yakima folds were identified a multiple number of times. These structures align with a set of three-dimensional planar structures identified with our unique Geologic Spatial Analysis (GSA) system. The GSA analysis is based upon computer automated detection of valley bottoms as defined by a DEM. Valley vectors which are coplanar may be controlled by a planar geologic structure whose three-dimensional orientation can be calculated by GSA routines. 58 refs., 7 figs.

  16. Fiber-reinforced framework in conjunction with porcelain veneers for the esthetic replacement of a congenitally missing maxillary lateral incisor: a case study.

    PubMed

    Benito, P P; Trushkowsky, R D; Magid, K S; David, S B

    2012-01-01

    This article presents a case of a congenitally missing right maxillary lateral incisor and the contralateral incisor with discolored composite resin restorations. The technique of fiber reinforcement in conjunction with porcelain veneers was used to provide a satisfactory outcome for the patient. The key learning points of the article are the following: proper diagnosis, treatment plan and appropriate utilization of materials are mandatory for a successful result. PMID:22621164

  17. A new species of Docosia Winnertz from Central Europe, with DNA barcoding based on four gene markers (Diptera, Mycetophilidae)

    PubMed Central

    Ševčík, Jan; Kaspřák, David; Rulik, Björn

    2016-01-01

    Abstract A new species of Docosia Winnertz, Docosia dentata sp. n., is described and illustrated, based on a single male specimen collected in Muránska planina National Park in Central Slovakia. DNA sequences (COI, COII, CytB, and ITS2) are included and compared for 13 species of Docosia. There was found only little congruence between the molecular results and previous scarce data about interspecific relationships based on morphology. The COI and CytB gene markers showed the highest interspecific gene distances while ITS2 showed the lowest ones. An updated key to the 23 Central European species of Docosia is also presented. PMID:26843833

  18. Is the notion of central fatigue based on a solid foundation?

    PubMed

    Contessa, Paola; Puleo, Alessio; De Luca, Carlo J

    2016-02-01

    Exercise-induced muscle fatigue has been shown to be the consequence of peripheral factors that impair muscle fiber contractile mechanisms. Central factors arising within the central nervous system have also been hypothesized to induce muscle fatigue, but no direct empirical evidence that is causally associated to reduction of muscle force-generating capability has yet been reported. We developed a simulation model to investigate whether peripheral factors of muscle fatigue are sufficient to explain the muscle force behavior observed during empirical studies of fatiguing voluntary contractions, which is commonly attributed to central factors. Peripheral factors of muscle fatigue were included in the model as a time-dependent decrease in the amplitude of the motor unit force twitches. Our simulation study indicated that the force behavior commonly attributed to central fatigue could be explained solely by peripheral factors during simulated fatiguing submaximal voluntary contractions. It also revealed important flaws regarding the use of the interpolated twitch response from electrical stimulation of the muscle as a means for assessing central fatigue. Our analysis does not directly refute the concept of central fatigue. However, it raises important concerns about the manner in which it is measured and about the interpretation of the commonly accepted causes of central fatigue and questions the very need for the existence of central fatigue. PMID:26655823

  19. Replacement of missing lateral incisors with lithium disilicate glass-ceramic veneer-fixed dental prostheses: a clinical report

    PubMed Central

    Bissasu, Sami M; Al-houri, Nabil A

    2014-01-01

    Key Clinical Message This report describes the use of lithium disilicate glass-ceramic veneer-fixed dental prostheses in replacing congenitally missing maxillary lateral incisors. This kind of prosthesis has an advantage over a lingual-retainer resin-bonded fixed dental prosthesis in its capability of changing the color and shape of the abutment teeth. The prostheses provided an acceptable esthetics and comfort for the patient. PMID:25356269

  20. Conservative Treatment of an Invaginated Maxillary Lateral Incisor with a C-shaped Canal Using Cone-Beam Computed Tomography.

    PubMed

    Forghani, Maryam; Moghim Farooji, Elaheh; Abuchenari, Javad; Bidar, Maryam; Eslami, Neda

    2015-01-01

    This report describes the non-surgical treatment of an invaginated maxillary lateral incisor with two fused roots. The mesial root had a C-shaped canal, while the distal one had a type III dens invagination. Cone-beam computed tomography (CBCT) was used to help with the diagnosis and treatment decision making. Clinical and radiographic follow-up revealed satisfactory periapical repair and absence of symptoms after 15 months. PMID:26576164

  1. The contribution of a central pattern generator in a reflex-based neuromuscular model

    PubMed Central

    Dzeladini, Florin; van den Kieboom, Jesse; Ijspeert, Auke

    2014-01-01

    Although the concept of central pattern generators (CPGs) controlling locomotion in vertebrates is widely accepted, the presence of specialized CPGs in human locomotion is still a matter of debate. An interesting numerical model developed in the 90s demonstrated the important role CPGs could play in human locomotion, both in terms of stability against perturbations, and in terms of speed control. Recently, a reflex-based neuro-musculo-skeletal model has been proposed, showing a level of stability to perturbations similar to the previous model, without any CPG components. Although exhibiting striking similarities with human gaits, the lack of CPG makes the control of speed/step length in the model difficult. In this paper, we hypothesize that a CPG component will offer a meaningful way of controlling the locomotion speed. After introducing the CPG component in the reflex model, and taking advantage of the resulting properties, a simple model for gait modulation is presented. The results highlight the advantages of a CPG as feedforward component in terms of gait modulation. PMID:25018712

  2. CrisprGE: a central hub of CRISPR/Cas-based genome editing

    PubMed Central

    Kaur, Karambir; Tandon, Himani; Gupta, Amit Kumar; Kumar, Manoj

    2015-01-01

    CRISPR system is a powerful defense mechanism in bacteria and archaea to provide immunity against viruses. Recently, this process found a new application in intended targeting of the genomes. CRISPR-mediated genome editing is performed by two main components namely single guide RNA and Cas9 protein. Despite the enormous data generated in this area, there is a dearth of high throughput resource. Therefore, we have developed CrisprGE, a central hub of CRISPR/Cas-based genome editing. Presently, this database holds a total of 4680 entries of 223 unique genes from 32 model and other organisms. It encompasses information about the organism, gene, target gene sequences, genetic modification, modifications length, genome editing efficiency, cell line, assay, etc. This depository is developed using the open source LAMP (Linux Apache MYSQL PHP) server. User-friendly browsing, searching facility is integrated for easy data retrieval. It also includes useful tools like BLAST CrisprGE, BLAST NTdb and CRISPR Mapper. Considering potential utilities of CRISPR in the vast area of biology and therapeutics, we foresee this platform as an assistance to accelerate research in the burgeoning field of genome engineering. Database URL: http://crdd.osdd.net/servers/crisprge/. PMID:26120138

  3. CrisprGE: a central hub of CRISPR/Cas-based genome editing.

    PubMed

    Kaur, Karambir; Tandon, Himani; Gupta, Amit Kumar; Kumar, Manoj

    2015-01-01

    CRISPR system is a powerful defense mechanism in bacteria and archaea to provide immunity against viruses. Recently, this process found a new application in intended targeting of the genomes. CRISPR-mediated genome editing is performed by two main components namely single guide RNA and Cas9 protein. Despite the enormous data generated in this area, there is a dearth of high throughput resource. Therefore, we have developed CrisprGE, a central hub of CRISPR/Cas-based genome editing. Presently, this database holds a total of 4680 entries of 223 unique genes from 32 model and other organisms. It encompasses information about the organism, gene, target gene sequences, genetic modification, modifications length, genome editing efficiency, cell line, assay, etc. This depository is developed using the open source LAMP (Linux Apache MYSQL PHP) server. User-friendly browsing, searching facility is integrated for easy data retrieval. It also includes useful tools like BLAST CrisprGE, BLAST NTdb and CRISPR Mapper. Considering potential utilities of CRISPR in the vast area of biology and therapeutics, we foresee this platform as an assistance to accelerate research in the burgeoning field of genome engineering. PMID:26120138

  4. Coal-based stratigraphy for upper Fort Union Group (Paleocene), west-central North Dakota

    SciTech Connect

    Groenewold, G.; Hemish, L.; Daly, D.J.; Schmit, C.

    1986-08-01

    On the basis of an evaluation of lithologic and geophysical logs from 2500 shallow drill holes and information from a limited number of natural outcrops and mine highwalls, a detailed stratigraphic framework was constructed for the Paleocene strata of the Sentinel Butte and upper Bullion Creek formations (upper Fort Union Group) in the Knife River area in west-central North Dakota. The study sequence was found to be characterized by at least seven major coals continuous over the 8000 km/sup 2/ (3089 mi/sup 2/) of the study area instead of a large number of locally persistent coals, as interpreted by previous investigations of surface sections. A series of geologic cross sections demonstrates the correlation of the lignite beds in the upper Bullion Creek and Sentinel Butte formations and together provide a three-dimensional picture of coal distribution in the study area. Each major lignite bed has been named and assigned both type and reference test holes. The recognition of coals continuous over the study area provides a means of correlating this complex terrestrial section. The resulting framework in turn provides a basis for (1) the development of a chronostratigraphy and biostratigraphy, (2) a more accurate evaluation of the magnitude and distribution of coal resources, and (3) an appraisal of depositional setting and history. The recognition of widespread coals in the upper Fort Union strata in other portions of the basin suggests the potential for establishing a basinwide stratigraphic framework based on these coals.

  5. The Relationship between Palatal Displacement of Upper Canines and Incisors Widths in a Syrian Sample of Patients with Uncrowded Arches.

    PubMed

    Mahaini, Luai

    2015-01-01

    The aim of this study investigates mesiodistal crown size of the maxillary and mandibular incisors of patients with palatally impacted canines (PDC). Pretreatment dental casts of orthodontic patients with PDC of one or both maxillary canines (N: 33) were collected. This PDC sample was matched according to age and sex with pretreatment dental casts from unaffected orthodontic patients. For the PDC and matched control samples, maximum mesiodistal crown diameters were recorded for the four incisors on the right side only. The results showed that, on average, the mesiodistal crown diameters for the maxillary and mandibular incisors measured smaller in the PDC sample than in the control sample. These findings of statistically significant tooth-size reductions associated with PDC occurrence indicate a generalized pattern of reduced tooth size as a characteristic associated with the PDC anomaly. Further, the presence of generalized tooth-size reduction in cases with palatally displaced canines help explain why most orthodontic treatment plans for PDC patients are of the nonextraction type. PMID:26718294

  6. Base of Principal Aquifer for the Elkhorn-Loup Model Area, North-Central Nebraska

    USGS Publications Warehouse

    McGuire, V.L.; Peterson, Sean M.

    2008-01-01

    In Nebraska, the water managers in the Natural Resources Districts and the Nebraska Department of Natural Resources are concerned with the effect of ground-water withdrawal on the availability of surface water and the long-term effects of ground-water withdrawal on ground- and surface-water resources. In north-central Nebraska, in the Elkhorn and Loup River Basins, ground water is used for irrigation, domestic supply, and public supply; surface water is used in this area for irrigation, recreation, and hydropower production. In recognition of these sometimes competing ground- and surface-water uses in the Elkhorn and Loup River Basins, the U.S. Geological Survey, the Lewis and Clark Natural Resources District, the Lower Elkhorn Natural Resources District, the Lower Loup Natural Resources District, the Lower Niobrara Natural Resources District, the Lower Platte North Natural Resources District, the Middle Niobrara Natural Resources District, the Upper Elkhorn Natural Resources District, and the Upper Loup Natural Resources District agreed to cooperatively study water resources in the Elkhorn and Loup River Basins. The goals of the overall study were to construct and calibrate a regional ground-water flow model of the area and to use that flow model as a tool to assess current and future effects of ground-water irrigation on stream base flow and to help develop long-term water-resource management strategies for this area, hereafter referred to as the Elkhorn-Loup model area. The Elkhorn-Loup model area covers approximately 30,800 square miles, and extends from the Niobrara River in the north to the Platte River in the south. The western boundary of the Elkhorn-Loup model area coincides with the western boundary of the Middle Niobrara, Twin Platte, and Upper Loup Natural Resources Districts; the eastern boundary coincides with the approximate location of the western extent of glacial till in eastern Nebraska. The principal aquifer in most of the Elkhorn-Loup model area is the High Plains aquifer; the principal aquifer in the remaining part of the Elkhorn-Loup model area is an unnamed alluvial aquifer. The upper surface of the geologic units that directly underlie the aquifer is called the 'base of aquifer' in this report. The geologic unit that forms the base of aquifer in the Elkhorn-Loup model area varies by location. The Tertiary-age Brule Formation generally is the base of aquifer in the west; the Cretaceous-age Pierre Shale generally is the base of aquifer in the east. The purpose of this report is to update the altitude and configuration of the base of the principal aquifer in the Elkhorn-Loup model area and a 2-mile buffer area around the Elkhorn-Loup model area, using base-of-aquifer data from test holes, registered water wells, and oil and gas wells within the Elkhorn-Loup model area and a 20-mile buffer area around the Elkhorn-Loup model area that have become available since the publication of earlier maps of the base of aquifer for this area. The base-of-aquifer map is important for the Elkhorn-Loup ground-water flow model because it defines the model's lower boundary. The accuracy of the Elkhorn-Loup ground-water flow model and the accuracy of the model's predictions about the effects of ground-water irrigation on stream base flow are directly related to the accuracy of the model's lower boundary.

  7. The adipocyte component of bone marrow in heterotopic bone induced by demineralized incisor grafts.

    PubMed

    W?odarski, Krzysztof H; Galus, Ryszard; Brodzikowska, Aniela; W?odarski, Pawe? K

    2012-01-01

    The relative proportion of adipocytes to hematopoietic elements in the marrow of heterotopically induced bone evaluated 4-42 weeks post implantation of demineralized murine incisors was estimated by histological analysis of hematoxylin-eosin stained tissue sections. Using computerized image analysis of microphotographs,the proportion of nuclear cells vs. adipocytes was ascertained. The percentage of adipocytes in marrow increases over time. Such an effect, the replacement of myelopoietic marrow by adipogenic (yellow) marrow and the resorption of induced bone, is observed in human osteoporosis. A decline in the non-adipogenic cell compartments of bone marrow accompanying induced bone begins in the fourth week of induction, gradually progresses until the 26th week, and does not change after that. The luminosity, a parameter used in image analysis and proportional to the number of nuclear cells, was 124 3 in hematopoietic femoral bone marrow, and that of bone marrow of the induced bone was of a similar value (117 8) in the fourth week. An evident decline in luminosity of bone marrow filling the foci of heterotopic bone was observed in samples taken at nine weeks (82 20). This process progressed until the 26th week, reaching a luminosity of 70 21. At the 42nd week, the luminosity remained at the same level (71 27). This indicates that the replacement of hematopoietic bone marrow of heterotopically induced bone by unilocular adipocytes begins relatively early (the fourth week) and is persistent. PMID:23042277

  8. Endodontic Management of a Maxillary Lateral Incisor with 4 Root Canals and a Dens Invaginatus Tract.

    PubMed

    Nosrat, Ali; Schneider, S Craig

    2015-07-01

    Dens invaginatus (DI) is associated with complex internal anatomy. This article represents a maxillary lateral incisor with 5 root canals including DI. The treatment was planned and performed using cone-beam computed tomographic (CBCT) imaging. After clinical and radiographic evaluations, tooth #7 was diagnosed with DI and pulp necrosis with symptomatic apical periodontitis. Periapical radiographs of the tooth showed 2 roots and complex internal anatomy. CBCT evaluation revealed tooth #7 had 5 separate canals (4 root canals and 1 DI canal extending through the root to the periodontal ligament), communication between DI and the root canal system, and severe and multiple curvatures of the palatal canals. Root canal treatment was completed in 2 visits. Modified access openings were required to safely treat the dilacerated palatal canals. At the 6-month re-evaluation, the patient reported he had remained asymptomatic and his tooth had remained functional since the treatment was completed. Clinical examination showed tooth #7 had no sensitivity to percussion or palpation, probe depths within normal limits (?3 mm), and no mobility. Radiographic assessment of the tooth showed significant osseous healing of the preoperative lesion. Three-dimensional imaging is a valuable tool for endodontic management of teeth with complex internal anatomy. Three-dimensional imaging is recommended for evaluating and treatment planning cases with DI. PMID:25799535

  9. A river based stable isotope record of orographic precipitation: Taurus Mountains, south central Turkey

    NASA Astrophysics Data System (ADS)

    Schemmel, Fabian; Mulch, Andreas; Mikes, Tamás.; Schildgen, Taylor

    2010-05-01

    Reconstructing continental precipitation and vegetation patterns has become one of the most rapidly growing fields in terrestrial paleoclimate research. Furthermore, stable isotopes in precipitation within continental plateau regions represent an increasingly important tool for reconstructing the various effects of uplift related climate change within the world's largest plateau regions. With peak elevations of more than 3,000 m the Taurus Mountains represent the southern margin of the central Anatolian plateau and must have played a pivotal role in controlling the drainage and sedimentation patterns within the plateau interior. However, their surface uplift history remains largely elusive. We sampled a series of tributaries and rivers along the Ermenek valley that crosscuts the Taurus Mountains in Southern Turkey. The aim of this study is to quantify the modern effect of orographic rainout of the Taurus Mountains on the d18O and dD values of river and spring waters and to compare these values to the d18O and dD of recent precipitation gathered by the Global Network of Isotopes in Precipitation (GNIP). Further we try to study the trends of the recent d18O and dD isotopic composition of local rivers and precipitation in the area to create a set of isotopic data that is comparable to isotopic studies on paleosoils and can therefore be used in future paleoaltimetry and paleoclimate studies. We sampled 6 individual rivers during the fall season 2008 to capture mostly groundwater runoff in the south central Taurus Mountains. All sampled rivers belong to the same local drainage system which drains into the Mediterranean Sea. The total elevation difference within the sampling area exceeds 2,000 m and we were able to collect samples over almost 1,800 m of elevation. Our measurements show that both d18O and dD values follow the same basic trend. d18O and dD values decrease systematically with increasing elevation. The lapse rate of d18O is about -2.2 per mil/km, whereas the lapse rate of dD is about -20 per mil/km. Select samples have higher d18O and dD values than expected for their respective elevations due to strong evaporative effects at the sampling sites. In areas of very steep topography (waterfalls, valley gorges) the d18O and dD values of water samples are biased towards values lower than expected for their respective elevations. However, such irregularities can be accounted for by plotting the measured isotopic compositions against the hypsometric mean elevations instead of the actual sampling elevations. Comparison with data gathered by the GNIP network at four neighboring stations (Adana, Antalya, Güzeloluk, and Kocebeyli) shows that the longer-term (1 to 18 years) isotopic composition of precipitation agrees very well with the data collected in this study. Collectively, the data presented here may serve as a modern template against which late Neogene proxy-based records of paleoprecipitation along the southern margin of the central Anatolian plateau may be calibrated.

  10. Basement structure based on gravity anomaly in the northern Noto peninsula, Central Japan

    NASA Astrophysics Data System (ADS)

    Mizubayashi, T.; Sawada, A.; Hamada, M.; Hiramatsu, Y.; Honda, R.

    2012-12-01

    Upper crustal block structures are usually defined by using surface information, such as geological and morphological data. The northern Noto Peninsula, central Japan, is divided into four geological block structures from tectonic geomorphologic perspectives (Ota and Hirakawa, 1979). This division is based on the surface crustal movement. To image the geological blocks three-dimensionally, it is necessary to construct a subsurface structure model. Gravity survey can clarify the detailed subsurface structure with dense gravity measurement. From the detailed Bouguer anomalies in the northwestern Noto Peninsula, Honda et al. (2008) suggested that the rupture size of the 2007 Noto Hanto earthquake was constrained by the geological block structures. Hiramatsu et al. (2008) also suggested the active faults on the seafloor, such as the source fault of the 2007 Noto Hanto earthquake plays a major role for the formation of the geological block structures. In this study, we analyze subsurface density structure based on the Bouguer anomaly and estimate the distribution of basement depth in the northern Noto Peninsula. We focus the relationship among the basement depth, the block structures and the active faults on the seafloor and discuss the block movement in the northern Noto Peninsula. We compiled the data measured and published previously (Gravity Database of Southwest Japan, 2001; Geological survey of Japan, 2004; Geographical survey institute of Japan, 2006; The Gravity Research Group in Southwest Japan, 2001; Komazawa and Okuma, 2010; Hokuriku electric power Co. Ltd., undisclosed) and calculated Bouguer anomaly in the northern Noto Peninsula. Based on this Bouguer anomaly, we analyzed subsurface density structures along 13 northeastern-southwestern profiles and 35 northwestern-southeastern profiles with the interval of 2 km using the two dimensional Talwani's method (Talwani et al., 1959). In the analysis, we assumed a density structure with four layers: basement (density is 2670kg/m3), Neocene volcanic rock (density is 2400kg/m3, or 2550kg/m3), Neocene sedimentary rock (density is 2200kg/m3), and Quaternary sedimentary rock (density is 1800kg/m3, or 1500kg/m3) (Honda et al., 2008). To compare our basement model to the geological block structures, we focus on a transition zone of the basement depth. We recognize that two of three geological block boundaries correspond to the transition zones. These boundaries also correspond to the boundary of active fault segments on the seafloor. Therefore, based on the relationship between the source fault of the 2007 Noto Hanto earthquake and the geological block, we suggest that the movement of those geological blocks is possibly controlled by the corresponding active fault segments. However, we find that the other block boundary doesn't correspond to the transition zone.

  11. Improvement of the Heisenberg and Fisher-information-based uncertainty relations for D-dimensional central potentials

    NASA Astrophysics Data System (ADS)

    Snchez-Moreno, P.; Gonzlez-Frez, R.; Dehesa, J. S.

    2006-12-01

    The Heisenberg and Fisher-information-based uncertainty relations are improved for stationary states of single-particle systems in a D-dimensional central potential. The improvement increases with the squared orbital hyperangular quantum number. The new uncertainty relations saturate for the isotropic harmonic oscillator wavefunction.

  12. The Most Proficient Enzyme as the Central Theme in an Integrated, Research-based Biochemistry Laboratory Course

    ERIC Educational Resources Information Center

    Smiley, Jeffrey A.

    2002-01-01

    The enzyme orotidine-5'-monophosphate decarboxylase is an attractive choice for the central theme of an integrated, research-based biochemistry laboratory course. A series of laboratory exercises common to most instructional laboratories, including enzyme assays, protein purification, enzymatic characterization, elementary kinetics, and

  13. New Reforms in the Management of the University: Transition from Centralized to Decentralized (University-Based Management) in Iran

    ERIC Educational Resources Information Center

    Mehralizadeh, Y.

    2005-01-01

    This article focuses on new reforms in Iran's higher education management system--Transition from centralized to decentralized (University-Based management--UBM). This is an important subject since Iran's Ministry of Science, Research, and Technology (MSRT) has begun to introduce new reforms for the improvement and the enhancement of Iranian

  14. An EO-Based Approach to Modelling Ecosystem Health in Response to Wildfire in Central Greece

    NASA Astrophysics Data System (ADS)

    Evans, Aaron; Petropoulos, George P.

    2014-05-01

    Assessment of ecosystem health is becoming more relevant in a world where ecosystems are being used unsustainably and have been showing increased signs of stress and dysfunction. Therefore, this research has set out to establish an Earth Observation (EO) based methodology in conjunction with Geographical Information Systems (GIS) to establish and monitor the indicators of ecosystem health in a region affected by wildfire in Central Greece. A further goal has been to assess the responses of ecosystem health to wildfire and urban expansion in the studied region. The methodology integrated GIS software and EO data to assess ecosystem characteristics including: vigour, organisation and resilience. The characteristics were quantified using remote sensing techniques focusing on Normalised Difference Vegetation Index (NDVI) images derived from Landsat imagery from 1999-2011. Topographic features including slope and aspect were extracted from a digital elevation model (DEM). These elements were then assigned weightings based upon research and combined in a model to produce a map of ecosystem health. The map of ecosystem health was validated against a compound topographic index that was produced for the study region, completed by overlaying the layers in Google Earth. This software allowed for a direct comparison of each layer. The results of the model have demonstrated correlations with past wildfires and the associated recovery. The findings are in agreement with the hypothesis that ecosystem health maps can illustrate the effect wildfires have on ecosystem health, thus providing useful information to land managers and policy makers who manage wildfire. The results further demonstrate that the resolution of Landsat imagery is excellent for obtaining a general overview of ecosystem health mapping. The methods described in this study could provide more detailed information if applied to high resolution imagery such as Worldview or IKONOS data. Results could be further enhanced with hyperspectral sensors due to the possibility of detecting chemical processes associated with ecosystem process. The method is robust enough to be transferable to other regions, with some minor changes based on a specified climate for a given location. The launch of Landsat 8 will ensure the continued acquisition and availability of Landsat data as well as provide high quality images, also making it possible to develop this method to potentially contribute to an operational estimation of ecosystem health recovery after wildfire.

  15. Epidemiology of Idiopathic Central Serous Chorioretinopathy in Taiwan, 20012006: A Population-based Study

    PubMed Central

    Tsai, Der-Chong; Chen, Shih-Jen; Huang, Chin-Chou; Chou, Pesus; Chung, Chia-Min; Huang, Po-Hsun; Lin, Shing-Jong; Chen, Jaw-Wen; Chen, Tseng-Ji

    2013-01-01

    Objectives The epidemiology of idiopathic central serous chorioretinopathy (CSCR) is not well understood in an Asian population. The present study aimed to investigate the incidence and risk factors for corticosteroid-unrelated CSCR using Taiwans National Health Insurance Research Database. Methods and Results From 2001 to 2006, a total of 786 patients (500 [63.6%] males) who were newly diagnosed with CSCR, aged from 20 to 64 years and had no history of corticosteroid prescription were identified as incident cases of idiopathic CSCR. 3606 age-, gender-, and enrollment time-matched subjects were randomly selected as the control group. The mean annual incidence was 0.21 (0.27 for males, and 0.15 for females; P<0.001), with a male/female ratio of 1.74. The peak incidence was in the 35- to 39-year-old age group (0.30), followed by the 40- to 44-year-old age group (0.26). Males had a significantly higher mean annual incidence than female only in the middle age groups. Conditional logistic regression was used to estimate the odds ratios (ORs) for potential risk factors of idiopathic CSCR. Only exposure to anti-anxiety drugs (OR, 1.63; 95% confidence interval, 1.092.44) was found to be independently associated with idiopathic CSCR among males. No risk factors of idiopathic CSCR were found for females. Conclusions This study provides the nationwide, population-based data on the incidence of idiopathic CSCR in adult Asians, and suggests that exposure to anti-anxiety drugs is an independent risk factor for idiopathic CSCR among males. PMID:23826160

  16. Remote Sensing Based Biophysical Characterization of Tropical Deciduous Forest in Central India

    NASA Astrophysics Data System (ADS)

    Singh, R. P.; Goroshi, S.; Sharma, N. K.; Bairagi, G. D.; Sharma, R.; Jalil, P.; Jain, A.; Sonakia, A.; Parihar, J. S.

    2011-09-01

    The paper reports the measurements of biophysical parameters using field and satellite data over a tropical deciduous forest Kanha National Park (KNP), central India. Field measurement (GBH, LAI, litter, soil moisture) was carried out over ten quadrates of 0.1ha in KNP for characterization of biophysical parameters with specified measurement protocol and sampling. Satellite based remote sensing analysis (LAI, Phenology, and NPP) was carried out using multi date observations of IRS-LISS-III, IMS-1MX, SPOT-VEGETATION and EOS-MODIS instruments. Rank correlation analysis using field data collected in the selected quadrates at KNP showed Sal (Shorea robusta) is dominant forest species followed by Lendia, Jamun (Syzygium cumini), Saja, Harra and Dhawda etc. Field measurement of Sal showed GBH range from 20 cm to 170 cm. Different forest classes such as Sal; Sal mixed with Jamun, Bamboo (Dendrocalamus strictus) etc, including grasslands/scrubland were classified with overall accuracy of 85.56 percent using March, May and October multi spectral data. Sal has distinct growth characteristics (low vegetation growth/ leaf fall in March instead of May) as compared to other vegetation species. As per the Leaf Area Index (LAI) measurement using hemispherical photographs, Sal showed the highest LAI (6.95 m2/m2) during September and lowest LAI (2.63 m2/m2) during March. Overall good agreement (r= 0.79) was found between the LAI generated from LISS-III and MODIS data product. It was observed from SPOT-VEGETATION analysis that NPP varied from 8.4 tC/ha/year (dry deciduous forest) to 14.25 tC/ha/year (Moist deciduous forest) in KNP.

  17. Classification of fast flows in central plasma sheet: Superposed epoch analysis based on THEMIS observations

    NASA Astrophysics Data System (ADS)

    Li, H.; Wang, C.; Fu, S. Y.

    2014-09-01

    A statistical survey of 560 fast flows in midnight central plasma sheet is performed based on Time History of Events and Macroscale Interactions during Substorms (THEMIS) observations during its first two tail phases. From superposed epoch analysis, no significant substorm activities are found to be associated with the occurrence of fast flows beyond X=-15 Re. Considering the associations with substorm activities, the fast flows inside of X=-15 Re can be classified into two obvious classes: short duration (< 2.0 min) and long duration (> 4.0 min). Substorm breakups are shown to be more closely correlated to short-duration fast flows. Furthermore, the onset of short-duration fast flows in the dipolarization region (X=-9 to -11 Re) is almost simultaneous with the onset of substorm breakups and dipolarizations. On the other hand, time delays of 2-4 min are both found in the near-Earth region (X=-7 to -9 Re) and in the near-tail region (X=-11 to -15 Re). Assuming that short-duration fast flows are generated by the force imbalance caused by cross-tail current disruption, these features are consistent with the predictions made by the cowling electrojet current loop and the cross-tail current disruption substorm models. In comparison, although more magnetic flux is transported toward Earth for long-duration fast flows, no clear substorm breakup is closely associated with them. The analysis of 2-D ion velocity distribution further shows some differences. For short-duration fast flows, multiple crescent-shaped ion populations are found. However, for long-duration fast flows, there exists only a single crescent-shaped ion population. The difference may be an important signature for distinguishing these two classes of fast flows.

  18. Attenuation Tomography Based on Strong Motion Data: Case Study of Central Honshu Region, Japan

    NASA Astrophysics Data System (ADS)

    Kumar, Parveen; Joshi, A.; Verma, O. P.

    2013-12-01

    Three-dimensional frequency dependent S-wave quality factor (Qβ(f)) value for the central Honshu region of Japan has been determined in this paper using an algorithm based on inversion of strong motion data. The method of inversion for determination of three-dimensional attenuation coefficients is proposed by H ashida and S himazaki (J Phys Earth. 32, 299-316, 1984) and has been used and modified by J oshi (Curr Sci. 90, 581-585, 2006; Nat Hazards. 43, 129-146, 2007) and J oshi et al. (J. Seismol. 14, 247-272, 2010). Twenty-one earthquakes digitally recorded on strong motion stations of Kik-net network have been used in this work. The magnitude of these earthquake ranges from 3.1 to 4.2 and depth ranging from 5 to 20 km, respectively. The borehole data having high signal to noise ratio and minimum site effect is used in the present work. The attenuation structure is determined by dividing the entire area into twenty-five three-dimensional blocks of uniform thickness having different frequency-dependent shear wave quality factor. Shear wave quality factor values have been determined at frequencies of 2.5, 7.0 and 10 Hz from record in a rectangular grid defined by 35.4°N to 36.4°N and 137.2°E to 138.2°E. The obtained attenuation structure is compared with the available geological features in the region and comparison shows that the obtained structure is capable of resolving important tectonic features present in the area. The proposed attenuation structure is compared with the probabilistic seismic hazard map of the region and shows that it bears some remarkable similarity in the patterns seen in seismic hazard map.

  19. Elevated Serum 25(OH)-Vitamin D Levels Are Negatively Correlated with Molar-Incisor Hypomineralization

    PubMed Central

    Thiering, E.; Kratzsch, J.; Heinrich-Weltzien, R.; Hickel, R.; Heinrich, J.; Wichmann, HE; Heinrich, J

    2015-01-01

    To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS > 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol/l (standard deviation 22.0 nmol/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television/personal computer (TV/PC) viewing hours, a 10 nmol/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters. PMID:25503610

  20. Intracanal bisphosphonate does not inhibit replacement resorption associated with delayed replantation of monkey incisors.

    PubMed

    Thong, Yo Len; Messer, Harold H; Zain, Rosnah Binti; Saw, Lip Hean; Yoong, Lai Thong

    2009-08-01

    Progressive replacement resorption following delayed replantation of avulsed teeth has proved to be an intractable clinical problem. A wide variety of therapeutic approaches have failed to result in the predictable arrest of resorption, with a good long-term prognosis for tooth survival. Bisphosphonates are used in the medical management of a range of bone disorders and topically applied bisphosphonate has been reported to inhibit root resorption in dogs. This study evaluated the effectiveness of a bisphosphonate (etidronate disodium) as an intracanal medicament in the root canals of avulsed monkey teeth, placed before replantation after 1 h of extraoral dry storage. Incisors of six Macaca fascicularis monkeys were extracted and stored dry for 1 h. Teeth were then replanted after canal contamination with dental plaque (negative control) or after root canal debridement and placement of etidronate sealed in the canal space. A positive control of calcium hydroxide placed 8-9 days after replantation was also included. All monkeys were sacrificed 8 weeks later and block sections were prepared for histomorphometric assessment of root resorption and periodontal ligament status. Untreated teeth showed the greatest extent of root resorption (46% of the root surface), which was predominantly inflammatory in nature. Calcium hydroxide treated teeth showed the lowest overall level of resorption (<30% of the root surface), while the bisphosphonate-treated group was intermediate (39%). Ankylosis, defined as the extent of the root surface demonstrating direct bony union to both intact and resorbed root surface, was the lowest in the untreated control group (15% of the root surface), intermediate in the calcium hydroxide group (27%) and the highest in the bisphosphonate group (41%). Bony attachment to the tooth root was divided approximately equally between attachment to intact cementum and to previously resorbed dentin. Overall, bisphosphonate resulted in a worse outcome than calcium hydroxide in terms of both root resorption and ankylosis. PMID:19459923

  1. Elevated serum 25(OH)-vitamin D levels are negatively correlated with molar-incisor hypomineralization.

    PubMed

    Khnisch, J; Thiering, E; Kratzsch, J; Heinrich-Weltzien, R; Hickel, R; Heinrich, J

    2015-02-01

    To date, the precise etiology of molar-incisor hypomineralization (MIH) is uncertain. Vitamin D plays a key role in hard tissue formation. Therefore, this study aimed to analyze the relationship between serum 25-hydroxy-vitamin D (25(OH)D) status and dental health data obtained from 1,048 children in a 10-year follow-up of the Munich GINIplus and LISAplus birth cohorts. The dental examination included the diagnosis of MIH and recording of (non-)cavitated caries lesions in primary and permanent teeth. Serum 25(OH)D concentrations were taken from blood samples of the 10-year investigation and measured with a fully automated, modular system. Different logistic regression and Poisson hurdle models were calculated. MIH was diagnosed in 13.6% of the study population. Approximately 16.4% of the children demonstrated caries-related defects (D3-4MFS > 0). The mean season-adjusted concentration of 25(OH)D was 75.8 nmol/l (standard deviation 22.0 nmol/l). After adjusting for sex, age, body mass index, parental education, equivalent income, and television/personal computer (TV/PC) viewing hours, a 10 nmol/l increase in serum 25(OH)D concentrations was significantly associated with a lower odds ratio of having MIH (OR = 0.89; P = 0.006). Furthermore, higher 25(OH)D values were associated with a lower number of caries-affected permanent teeth. It is concluded that elevated serum 25(OH)D concentrations were associated with better dental health parameters. PMID:25503610

  2. Prenatal factors associated with the neonatal line thickness in human deciduous incisors.

    PubMed

    Kurek, M; ??dzi?ska, E; Sitek, A; Borowska-Strugi?ska, B; Rosset, I; Lorkiewicz, W

    2015-06-01

    The neonatal line (NNL) is used to distinguish developmental events observed in enamel which occurred before and after birth. However, there are few studies reporting relationship between the characteristics of the NNL and factors affecting prenatal conditions. The aim of the study was to determine prenatal factors that may influence the NNL thickness in human deciduous teeth. The material consisted of longitudinal ground sections of 60 modern human deciduous incisors obtained from full-term healthy children with reported birth histories and prenatal factors. All teeth were sectioned in the labio-lingual plane using diamond blade (Buechler IsoMet 1000). Final specimens were observed using scanning electron microscopy at magnifications 320. For each tooth, linear measurements of the NNL thickness were taken on its labial surface at the three levels from the cemento-enamel junction. The difference in the neonatal line thickness between tooth types and between males and females was statistically significant. A multiple regression analyses confirmed influence of two variables on the NNL thickness standardised on tooth type and the children's sex (z-score values). These variables are the taking of an antispasmodic medicine by the mother during pregnancy and the season of the child's birth. These two variables together explain nearly 17% of the variability of the NNL. Children of mothers taking a spasmolytic medicine during pregnancy were characterised by a thinner NNL compared with children whose mothers did not take such medication. Children born in summer and spring had a thinner NNL than children born in winter. These results indicate that the prenatal environment significantly contributes to the thickness of the NNL influencing the pace of reaching the post-delivery homeostasis by the newborn's organism. PMID:25618810

  3. Direct evidence of central European forest refugia during the last glacial period based on mollusc fossils

    NASA Astrophysics Data System (ADS)

    Juřičková, Lucie; Horáčková, Jitka; Ložek, Vojen

    2014-07-01

    Although there is evidence from molecular studies for the existence of central European last glacial refugia for temperate species, there is still a great lack of direct fossil records to confirm this theory. Here we bring such evidence in the form of fossil shells from twenty strictly forest land snail species, which were recorded in radiocarbon-dated late glacial or older mollusc assemblages of nine non-interrupted mollusc successions situated in the Western Carpathians, and one in the Bohemian Massif. We proposed that molluscs survived the last glacial period in central Europe in isolated small patches of broadleaf forest, which we unequivocally demonstrate for two sites of last glacial maximum age.

  4. Geodiversity of the Umbria region (central Italy): a GIS-based quantitative index

    NASA Astrophysics Data System (ADS)

    Melelli, Laura; Pica, Alessia; Del Monte, Maurizio

    2014-05-01

    The measure of natural range related to geological bedrock, landforms and geomorphological processes is the necessary starting point to geodiversity evaluation. Geodiversity plays a strategic role in landscape management. Whereas geotourism and geosites are identified as a driving power for the scientific and economic promotion of an area, the geodiversity knowledge is required for a complete and accurate research. For example, high values of this abiotic parameter identify and support the foundation of geoparks. According to this perspective, the geodiversity is the unifying factor for these areas of interest. While a subjective and qualitative approach may be adequate for geosites definition, identification and cultural promotion, the geodiversity concept needs a different evaluation method. A quantitative procedure allows achieving an objective and repeatable process exportable in different geographic units. Geographical Information Systems and spatial analysis techniques are the base to quantitative evaluation involving topographic, geological and geomorphological data. Therefore, the assessment of a numerical index derived from the overlay of spatial parameters can be conveniently computed in GIS environment. In this study, a geodiversity index is proposed where geological, geomorphological and landcover factors deriving mainly from maps and field survey; topographic ones are employed from DEM and remote sensed data. Each abiotic parameter is modelled in a grid format; focal functions do provide neighbourhood analysis and computing variety statistics. A particular extent is dedicated to topographic information and terrain roughness, that are strictly related to efficiency of geomorphological processes and generally corresponding to the abiotic components variability. The study area is located in central Italy and is characterized by a well known natural heritage. Thirty-seven geosites are detected in the Umbria region, where seven regional and one natural parks are present. All the area shows a strong correlation between the geological setting and the relief energy associated to topography assessment. Three main outcrop complexes are present: a fluvial lacustrine, where the lowest slope values and plain area are widespread; a terrigenous one, with a medium slope value; and a calcareous complex corresponding to the mountain areas and the highest amplitude of relief. This partition matches different geomorphological processes and landforms, ensuring a widespread distribution of geodiversity. The final map is a digital data that localizes areas with, respectively, null or minimum, medium, and high geodiversity values. The highest class overlaps to geosites areas, to high values of amplitude of relief and where the geomorphological processes are more effective and various. This confirms the method accuracy. The results obtained represent an important advancement in geodiversity research and a significant instrument for economic development and conservation management.

  5. Estimation of Evapotranspiration of Almond orchards using Remote Sensing based SEBAL model in Central Valley, California

    NASA Astrophysics Data System (ADS)

    Roy, S.; Ustin, S.; Kefauver, S. C.

    2009-12-01

    Evapotranspiration is one of the main components of the hydrologic cycle and its impact to hydrology, agriculture,forestry and environmental studies is very crucial. SEBAL (Surface Energy Balance Algorithm for Land) is an image-processing model comprised of twenty-five computational sub-models that computes actual evapotranspiration (ETa) and other energy exchanges as a component of energy balance which is used to derive the surface radiation balance equation for the net surface radiation flux (Rn) on a pixel-by-pixel basis. For this study, SEBAL method is applied to Level 1B dataset of visible, near-infrared and thermal infrared radiation channels of MASTER instrument on-board NASA-DC 8 flight. This paper uses the SEBAL method to (1) investigate the spatial distribution property of land surface temperature (Ls), NDVI, and ETa over the San Joaquin valley. (2) Estimate actual evapotranspiration of almond class on pixel-by-pixel basis in the Central valley, California. (3) Comparison of actual Evapotranspiration obtained from SEBAL model with reference evapotranspiration (Eto) using Penman Monteiths method based on the procedures and available data from California Irrigation Management Information System (CIMIS) stations. The results of the regression between extracted land surface temperature, NDVI and, evapotranspiration show negative (-) correlation. On the other hand Ls possessed a slightly stronger negative correlation with the ETa than with NDVI for Almond class. The correlation coefficient of actual ETa estimates from remote sensing with Reference ETo from Penmann Monteith are 0.8571. ETa estimated for almond crop from SEBAL were found to be almost same with the CIMIS_Penman Monteith method with bias of 0.77 mm and mean percentage difference is 0.10%. These results indicate that combination of MASTER data with surface meteorological data could provide an efficient tool for the estimation of regional actual ET used for water resources and irrigation scheduling and management. Keywords: Evapotranspiration, Hydrologic cycle, SEBAL, net surface radiation flux, MASTER, NDVI, Penman Monteith, CIMIS, Surface Temperature

  6. Sexual Precocity - Genetic Bases of Central Precocious Puberty and Autonomous Gonadal Activation.

    PubMed

    Macedo, Delanie Bulco; Silveira, Letcia Ferreira Gontijo; Bessa, Danielle Souza; Brito, Vinicius Nahime; Latronico, Ana Claudia

    2016-01-01

    Precocious puberty has been classically defined as the onset of sexual secondary characteristics in girls younger than 8 years and in boys younger than 9 years. The discovery of potential factors which trigger human puberty is one of the central mysteries of reproductive biology. Several approaches, including mutational analysis of candidate genes, large-scale genome-wide association studies, and (more recently) whole-exome sequencing, have been performed in attempt to identify novel genetic factors that modulate the human hypothalamic-pituitary-gonadal axis, resulting in premature sexual development. In the last two decades, it has been well established that autonomous gonadal activation can be caused by somatic (GNAS) or germline (LHCGR)-activating mutations of genes that encode essential elements for signal transduction of G protein-coupled receptors, resulting in peripheral precocious puberty in McCune-Albright syndrome and testotoxicosis, respectively. More recently, dominant activating and inactivating mutations of excitatory (KISS1/KISS1R) and inhibitory (MKRN3) modulators of gonadotropin-releasing hormone secretion, respectively, were associated with central precocious puberty phenotype. Indeed, loss-of-function mutations of MKRN3, a maternal imprinted gene located at chromosome 15q, currently represent a frequent cause of central precocious puberty diagnosed in families from distinct geographic origins. Here, we review the known genetic defects in central and peripheral precocious puberty. PMID:26680572

  7. A Centralized, Computerized, and Relational Data Base for Student Clinical Placements.

    ERIC Educational Resources Information Center

    Lears, Mary Kathleen; Olsen, Sharon J.; Morrison, Candis; Vessey, Judith A.

    1998-01-01

    A centralized relational database is used to manage information on advanced practice nursing students and their preceptors at Johns Hopkins University. The system relieves faculty of time-consuming tasks and enables rapid report generation, consistent tracking, and timely communications. (SK)

  8. Sensor-based mapping of soil quality on degraded claypan landscapes of the central United States

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Claypan soils (Epiaqualfs) in the central USA have experienced severe erosion as a result of tillage practices of the late 1800s and 1900s. Because of the site-specific nature of erosion processes within claypan fields, research is needed to achieve cost-effective sensing and mapping of soil and lan...

  9. Associations of central and brachial blood pressure with cognitive function: a population-based study.

    PubMed

    Nilsson, E D; Elmsthl, S; Minthon, L; Nilsson, P M; Pihlsgrd, M; Ngga, K

    2016-02-01

    Previous observational studies on the association between brachial blood pressure (BP) and cognition have reported conflicting results. Central BP has been hypothesized to be more strongly related to cognition than brachial BP. The aim of this study was to assess the association between brachial as well as central BP and cognitive function, both cross-sectionally and with brachial BP measured 17 years before cognitive testing. The study population comprised 2548 individuals aged 61-85 years at follow-up (61.4% women). The cognitive tests administered were A Quick Test of cognitive speed and the Mini Mental State Examination. In fully adjusted linear regressions, small but significant cross-sectional associations were found between higher BP (systolic, diastolic and pulse pressure) and worse results on both of the cognitive tests (P-values <0.05). No significant prospective associations were found. Central BP did not show a stronger association than brachial BP did. After stratification, significant results were mainly found in the group taking BP-lowering drugs at follow-up. In summary, these findings add to existing evidence on the relationship between BP and cognition, but they do not support a superior role of central compared with brachial BP in the elderly. PMID:25880593

  10. Geodynamics of Central Europe Based On Observations of The GPS Euref Stations

    NASA Astrophysics Data System (ADS)

    Schenk, V.

    When azimuths of the horizontal movement vectors processed from GPS data mon- itored during several campaigns on regional networks situated in the Central Europe (the East Sudeten, the West Alps, the Trans-Alpen area) were compared, they dis- played remarkable changed in their values evaluated from two sequential campaigns with respect to next ones. As adopted, the GPS data processed of one campaign are ordinarily linked to a close EUREF station (or stations) to be joined to an Interna- tional Terrestrial Reference Frame (ITRF). Even though the interconnection to the ITRF, the vector azimuths for one site evaluated from different campaigns can still show changes. To eliminate this effect, available movements of the Central European EUREF stations were analysed with respect to geological structural units in that rela- tively coincident character of geodynamic movements are expected. Several "geody- namic" units were identified and delineated for an area of the Central Europe. Then, directions of the horizontal vector azimuths of network sites were incorporated into the unit scheme above mentioned. The paper will present data analysis of the EU- REF stations, the geodynamic unit scheme for the Central Europe and comparisons of geodynamic horizontal movements of the EUREF stations and the network sites. Fur- ther, an assessment of interrelated movements among the individual structural units was estimated. The geodynamic pattern of Central European unit movements brings more transparent understanding of mutual relations between EUREF stations and the regional GPS networks observations. The data analyse of GPS observations were sup- ported by the program of Ministry of Education, Youth and Sport 'Research Centre', No. LN00A005, and by the project of the Grant Agency of the Czech Republic, No. 205/01/0480.

  11. Prediction of extreme floods in the eastern Central Andes based on a complex networks approach

    NASA Astrophysics Data System (ADS)

    Boers, N.; Bookhagen, B.; Barbosa, H. M. J.; Marwan, N.; Kurths, J.; Marengo, J. A.

    2014-10-01

    Changing climatic conditions have led to a significant increase in the magnitude and frequency of extreme rainfall events in the Central Andes of South America. These events are spatially extensive and often result in substantial natural hazards for population, economy and ecology. Here we develop a general framework to predict extreme events by introducing the concept of network divergence on directed networks derived from a non-linear synchronization measure. We apply our method to real-time satellite-derived rainfall data and predict more than 60% (90% during El Nio conditions) of rainfall events above the 99th percentile in the Central Andes. In addition to the societal benefits of predicting natural hazards, our study reveals a linkage between polar and tropical regimes as the responsible mechanism: the interplay of northward migrating frontal systems and a low-level wind channel from the western Amazon to the subtropics.

  12. Prediction of extreme floods in the eastern Central Andes based on a complex networks approach.

    PubMed

    Boers, N; Bookhagen, B; Barbosa, H M J; Marwan, N; Kurths, J; Marengo, J A

    2014-01-01

    Changing climatic conditions have led to a significant increase in the magnitude and frequency of extreme rainfall events in the Central Andes of South America. These events are spatially extensive and often result in substantial natural hazards for population, economy and ecology. Here we develop a general framework to predict extreme events by introducing the concept of network divergence on directed networks derived from a non-linear synchronization measure. We apply our method to real-time satellite-derived rainfall data and predict more than 60% (90% during El Nio conditions) of rainfall events above the 99th percentile in the Central Andes. In addition to the societal benefits of predicting natural hazards, our study reveals a linkage between polar and tropical regimes as the responsible mechanism: the interplay of northward migrating frontal systems and a low-level wind channel from the western Amazon to the subtropics. PMID:25310906

  13. Mineral Deposit Data for Epigenetic Base- and Precious-metal and Uranium-thorium Deposits in South-central and Southwestern Montana and Southern and Central Idaho

    USGS Publications Warehouse

    Klein, T.L.

    2004-01-01

    Metal deposits spatially associated with the Cretaceous Boulder and Idaho batholiths of southwestern Montana and southern and central Idaho have been exploited since the early 1860s. Au was first discovered in placer deposits; exploitation of vein deposits in bedrock soon followed. In 1865, high-grade Ag vein deposits were discovered and remained economically important until the 1890s. Early high-grade deposits of Au, Ag and Pb were found in the weathered portions of the veins systems. As mining progressed to deeper levels, Ag and Pb grades diminished. Exploration for and development of these vein deposits in this area have continued until the present. A majority of these base- and precious-metal vein deposits are classified as polymetallic veins (PMV) and polymetallic carbonate-replacement (PMR) deposits in this compilation. Porphyry Cu and Mo, epithermal (Au, Ag, Hg and Sb), base- and precious-metal and W skarn, W vein, and U and Th vein deposits are also common in this area. The world-class Butte Cu porphyry and the Butte high-sulfidation Cu vein deposits are in this study area. PMV and PMR deposits are the most numerous in the region and constitute about 85% of the deposit records compiled. Several types of syngenetic/diagenetic sulfide mineral deposits in rocks of the Belt Supergroup or their equivalents are common in the region and they have been the source of a substantial metal production over the last century. These syngenetic deposits and their metamorphosed/structurally remobilized equivalents were not included in this database; therefore, deposits in the Idaho portion of the Coeur d'Alene district and the Idaho Cobalt belt, for example, have not been included because many of them are believed to be of this type.

  14. Feasibility study for establishing a centralized geothermal data base for New Mexico. Final report, June 1, 1979-October 15, 1979

    SciTech Connect

    Klimowicz, G.; Martin, N.

    1980-01-01

    The purpose of this work is to catalog the information available and to make recommendations toward improving its accessibility. Existing computerized and non-computerized data sources are identified at both the state and national level. The content and accessibility of each such data base are investigated, as well as its suitability for aiding geothermal development. A catalog of such information is provided for each of the following data sources: GEOTHERM, WATSORE, STORIT, RPPM, GRID, HISS, EID air quality, and EID water quality. The available computing facilities within the state are evaluated for their appropriateness as a central storage facility for the many data sources. Recommendations are made for the establishment of a centralized geothermal/environmental data base. Included are recommendations for the computing facilities to be used by such a data base. How to obtain access to a given data base is described. This includes whether the data base is accessible from within New Mexico, necessary agreements, and contact persons. A glossary of computer-related terms and a brief description of knowledge-based problem-solving are included. (MHR)

  15. The design of future central receiver power plants based on lessons learned from the Solar One Pilot Plant

    SciTech Connect

    Kolb, G.J.

    1991-01-01

    The 10-MW{sub e} Solar One Pilot Plant was the world's largest solar central receiver power plant. During its power production years it delivered over 37,000 MWhrs (net) to the utility grid. In this type of electric power generating plant, large sun-tracking mirrors called heliostats reflect and concentrate sunlight onto a receiver mounted on top a of a tower. The receiver transforms the solar energy into thermal energy that heats water, turning it into superheated steam that drives a turbine to generate electricity. The Solar One Pilot Plant successfully demonstrated the feasibility of generating electricity with a solar central receiver power plant. During the initial 2 years the plant was tested and 4 years the plant was operated as a power plant, a great deal of data was collected relating to the efficiency and reliability of the plant's various systems. This paper summarizes these statistics and compares them to goals developed by the US Department of Energy. Based on this comparison, improvements in the design and operation of future central receiver plants are recommended. Research at Sandia National Laboratories and the US utility industry suggests that the next generation of central receiver power plants will use a molten salt heat transfer fluid rather than water/steam. Sandia has recently completed the development of the hardware needed in a molten salt power plant. Use of this new technology is expected to solve many of the performance problems encountered at Solar One. Projections for the energy costs from these future central receiver plants are also presented. For reference, these projections are compared to the current energy costs from the SEGS parabolic trough plants now operating in Southern California.

  16. Headset Bluetooth and cell phone based continuous central body temperature measurement system.

    PubMed

    Sanches, J Miguel; Pereira, Bruno; Paiva, Teresa

    2010-01-01

    The accurate measure of the central temperature is a very important physiologic indicator in several clinical applications, namely, in the characterization and diagnosis of sleep disorders. In this paper a simple system is described to continuously measure the body temperature at the ear. An electronic temperature sensor is coupled to the microphone of a common commercial auricular Bluetooth device that sends the temperature measurements to a mobile phone to which is paired. The measurements are stored at the mobile phone and periodically sent to a medical facility by email or SMS (short messaging service). PMID:21095713

  17. Comparative investigation of the traumatic injuries' prevalence of primary and permanent incisors at children aged 3 to 14.

    PubMed

    Belcheva, Anni B; Ilieva, Emilia L; Veleganova, Vania Kr

    2003-01-01

    Traumatic injures distribution of children's teeth is determined of different factors at different ages: beginning to walk, games, sport, orthodontic anomalies. The aim of this investigation is to compare tooth traumatic injures distribution of temporary and permanent incisors at children aged 3 to 14. Object of investigation are 1825 children aged 3 to 14 from the town of Plovdiv. A clinical dental examination has been carried out and had been registrated: expulsio dentis, fractura coronae dentis involving only the enamel, involving and the dentin, exposing the pulp. There also has been pointed out if the fracture is treated or not. The data received has been statistically processed. The results show that tooth traumatic injures distribution at primary teeth is 31-40 per cent of boys and 16-30 per cent of girls and at permanent teeth is 12-33 per cent of boys and 4-19 per cent of girls. There is a statistical significance of differences between tooth traumatic injures of primary and permanent incisors. PMID:12943058

  18. Temperature changes on the root surfaces of mandibular incisors after an 810-nm high-intensity intracanal diode laser irradiation

    NASA Astrophysics Data System (ADS)

    da Fonseca Alvarez, Andrea; Moura-Netto, Cacio; Daliberto Frugoli, Alexandre; Fernando, Casemiro; Correa Aranha, Ana Cecilia; Davidowicz, Harry

    2012-01-01

    Temperature changes caused by laser irradiation can promote damage to the surrounding dental tissues. In this study, we evaluated the temperature changes of recently extracted human mandibular incisors during intracanal irradiation with an 810-nm diode laser at different settings. Fifty mandibular incisors were enlarged up to an apical size of ISO No. 40 file. After the final rinse with 17% ethylenediaminetetraacetic acid, 0.2% lauryl sodium sulfate biologic detergent, and sterile water, samples were irradiated with circular movements from apex to crown through five different settings of output power (1.5, 2.0, 2.5, 3.0, and 3.5 W) in continuous mode. The temperature changes were measured on both sides of the apical and middle root thirds using two thermopar devices. A temperature increase of 7 C was considered acceptable as a safe threshold when applying the diode laser. Results: The results showed that only 3.5-W output power increased the outer surface temperature above the critical value. Conclusion: The recommended output power can be stipulated as equal to or less than 3 W to avoid overheating during diode laser irradiation on thin dentin walls.

  19. Fracture resistance of cementum-extended composite fillings in severely damaged deciduous incisors: An in vitro study

    PubMed Central

    Seraj, Bahman; Ehsani, Sara; Taravati, Shirin; Ghadimi, Sara; Fatemi, Mostafa; Safa, Sahar

    2014-01-01

    Objective: The aim of this study was to comparatively assess the fracture resistance of the cementum-extended and conventional composite fillings with or without intracanal composite posts in severely damaged deciduous incisors. Materials and Methods: This in vitro study was performed on 60 extracted deciduous maxillary incisors that were randomly divided into four groups: Group 1: Composite filling (CF); Group 2: Composite filling with composite posts (CF + CP); Group 3: Composite filling extended 0.5 mm to cementum (ceCF); Group 4: Composite filling extended 0.5 mm to cementum with composite posts (ceCF + CP). The fracture resistance was assessed by exerting a progressively increasing load with a cross-head speed of 0.5 mm/min in a Universal Testing Machine. Statistical Analysis: Data were analyzed by SPSS-18 using one-way analysis of variance at ? < 0.05. Results: The mean fracture resistance (MFR) values of the experimental groups were 410.57 139.44 N, 564.44 92.63 N, 507.5 76.37 N and 601.08 96.04 N. A significant difference was found between the MFR of Groups 1 and 2, Groups 1 and 4 and Groups 3 and 4 (P < 0.05). Conclusion: A superior outcome was achieved by intracanal composite posts in both conventional and cementum-extended composite fillings. PMID:25512722

  20. An Immature Type II Dens Invaginatus in a Mandibular Lateral Incisor with Talon's Cusp: A Clinical Dilemma to Confront

    PubMed Central

    Singal, Deepa; Giri, K. Y.; Keerthi, S. Sruthi

    2014-01-01

    Dens invaginatus (DI) is a malformation of teeth probably resulting from an infolding of the dental papilla during tooth development. DI is classified as type I, II, and III by Oehlers depending on the severity of malformation. The maxillary lateral incisor is the most commonly affected tooth. Structural defects do exist in the depth of the invagination pits, and as a consequence, the early development of caries and the subsequent necrosis of the dental pulp, as well as abscess and cyst formation are clinical implications associated with DI. Occasionally, we can see more than one developmental anomaly occurring in a single tooth. In such cases it becomes important to identify the anomalies and initiate a proper treatment plan for good prognosis. In this paper, an unusual case of DI which clinically presented as a huge talons cusp affecting a mandibular lateral incisor tooth is described. This case report illustrates grinding of the talons cusp followed by nonsurgical endodontic management of dens invaginatus type II with an immature apex and periapical lesions, in which Mineral Trioxide Aggregate (MTA) shows a complete periapical healing with bone formation at the site of the lesions. PMID:24660071

  1. Endodontic and periodontal management of a severely affected maxillary lateral incisor having combined mucosal fenestration and palatogingival groove

    PubMed Central

    Sharma, Sarang; Srivastava, Dhirendra; Sood, Vishal; Yadav, Priya

    2015-01-01

    Mucosal fenestrations, wherein the tooth root apices are clinically discernible in the oral cavity subsequent to loss of overlying alveolar bone and mucosa, are rare pathologic entities. Palato gingival grooves- anatomic aberrations are also infrequent occurrences that notoriously predispose to periodontal pathologies of varying extent. Both conditions independently are known to popularly affect maxillary lateral incisors. Coexistent fenestration defect and palato gingival groove in the same tooth is extremely rare and undoubtedly is a perfect combination to precipitate severe endodontic-periodontal consequences. In this report, a 34-year-old patient presented to the dental department with complaint of esthetics in relation to exposed root of right maxillary lateral incisor. On closer inspection, a palato gingival groove in addition to fenestration defect was evident on the root surface along with a periodontal pocket of >5 mm. An interdisciplinary treatment was instituted which included endodontic treatment followed by root end resection, osseous bone graft placement and guided tissue regeneration procedures for repair of mucosal fenestration defect. Debridement of the palatal pocket, with saucerization of the groove and restoration with glass ionomer cement were simultaneously employed to correct the palatal defect. PMID:26229283

  2. Effect of Ligation Method on Maxillary Arch Force/Moment Systems for a Simulated Lingual Incisor Malalignment

    PubMed Central

    Seru, Surbhi; Romanyk, Dan L; Toogood, Roger W; Carey, Jason P; Major, Paul W

    2014-01-01

    Introduction: The objectives of this study were to determine whether there is a difference in the magnitude of forces and moments produced by elastic ligation when compared to passive ligation, and whether these forces and moments propagate differently along the arch for the two ligation types. A lingual incisor malalignment was used in this study. Methods: The Orthodontic Simulator (OSIM) was used to quantify the three-dimensional forces and moments applied on the teeth given a lingually displaced incisor. A repeated measures MANOVA was performed to statistically analyze the data. Results: The interaction factor illustrated convincing evidence that there is a difference in maximum force and moment values for all outcome variables between ligation types considering all tooth positions along the arch. The mean differences for FX and FY between ligation types were found to be clinically significant, with values for elastic ligation consistently higher than passive ligation. Conclusion: It was found that the maximum forces and moments produced by elastic ligation are greater than those produced by passive ligation and that the magnitude of this difference for the mesiodistal and buccolingual forces is clinically relevant. Additionally, it was determined that elastic ligation causes forces and moments to propagate further along the arch than passive ligation for all outcome variables. PMID:25400715

  3. An Immature Type II Dens Invaginatus in a Mandibular Lateral Incisor with Talon's Cusp: A Clinical Dilemma to Confront.

    PubMed

    Gangwar, Anshul; Singal, Deepa; Giri, K Y; Agarwal, Anshita; Keerthi, S Sruthi

    2014-01-01

    Dens invaginatus (DI) is a malformation of teeth probably resulting from an infolding of the dental papilla during tooth development. DI is classified as type I, II, and III by Oehlers depending on the severity of malformation. The maxillary lateral incisor is the most commonly affected tooth. Structural defects do exist in the depth of the invagination pits, and as a consequence, the early development of caries and the subsequent necrosis of the dental pulp, as well as abscess and cyst formation are clinical implications associated with DI. Occasionally, we can see more than one developmental anomaly occurring in a single tooth. In such cases it becomes important to identify the anomalies and initiate a proper treatment plan for good prognosis. In this paper, an unusual case of DI which clinically presented as a huge talons cusp affecting a mandibular lateral incisor tooth is described. This case report illustrates grinding of the talons cusp followed by nonsurgical endodontic management of dens invaginatus type II with an immature apex and periapical lesions, in which Mineral Trioxide Aggregate (MTA) shows a complete periapical healing with bone formation at the site of the lesions. PMID:24660071

  4. Unusual orthodontic approach to a maxillary canine-premolar transposition and a missing lateral incisor with long-term follow-up.

    PubMed

    Farret, Milton Meri Benitez; Farret, Marcel Marchiori; Farret, Alessandro Marchiori; Hollweg, Henrique

    2012-11-01

    In this case report, we present an unusual approach that was used to treat a 14-year-old patient with a bilateral canine-premolar transposition and a missing maxillary lateral incisor. The orthodontic treatment involved maintaining the transposition and creating a space for lateral incisor replacement. Toward the end of the treatment, accentuated buccal root torque was performed, and lateral group function was established to improve the treatment outcome. Finally, an ideal esthetic and functional occlusion was achieved. The 8-year posttreatment follow-up records show the stability of this treatment. PMID:23116510

  5. Polytropic index of central plasma sheet ions based on MHD Bernoulli integral

    NASA Astrophysics Data System (ADS)

    Pang, Xuexia; Cao, Jinbin; Liu, Wenlong; Ma, Yuduan; Lu, Haoyu; Yang, Junying; Li, Liuyuan; Liu, Xu; Wang, Jing; Wang, Tieyan; Yu, Jiang

    2015-06-01

    This paper uses the data of Cluster from 2001 to 2009 to study the polytropic processes of central plasma sheet (CPS) ions. We first adopt the approach of MHD Bernoulli integral (MBI) to identify homogeneous streamflow tubes (quasi-invariant MBI regions) and then calculate the polytropic index of ions for those streamflow tubes whose outward electromagnetic energy ratios δ < 0.05. The central plasma sheet is actually a complicated system, which comprises many streamflow tubes with different polytropic relations and the transition layers in between. The polytropic indexes of the CPS ions range from 0.1 to 1.8 and have a quasi-Gaussian distribution. The median polytropic index is 0.93 for AE < 200 nT and 0.91 for AE ≥ 200 nT. Thus, there is no obvious difference between the polytropic indexes of the quiet time and the substorm time CPS ions, which suggests that the thinning and thickening processes of plasma sheet during substorm times do not change obviously the polytropic relation of the CPS ions. The statistical analysis using different δ (δ < 0.05, 0.025, and 0.01) shows that the outward emission of electromagnetic energy is an effective cooling mechanism and can make the polytropic index to decrease and shift toward isobaric. It is inferred that the CPS ions as a whole much likely behave in a way between isobaric and isothermal.

  6. How long has the central-northern Greenland Ice Sheet been melting at the base?

    NASA Astrophysics Data System (ADS)

    Rogozhina, Irina; Petrunin, Alexey G.; Johnson, Jesse V.; Vaughan, Alan P. M.

    2014-05-01

    Ice-penetrating radar studies (Fahnestock et al., 2001) and the deep ice core project NGRIP (Anderson et al., 2004) have identified extensive areas of rapid basal melt under the central-northern Greenland Ice Sheet (GIS). Our new reconstruction of the lithosphere structure in Greenland reveal that strong anomalies in geothermal heat flux are responsible for much of the estimated ice loss through basal melt. We use our coupled lithosphere-GIS model to study the history of basal ice conditions since the Pliocene period and find that the anomalous heat flow has been maintaining basal ice melt throughout the history of Greenland glaciation. Persistence of basal melt water over the course of ~3.5 million years and periodic development of paleo ice streams originating at the anomaly have likely caused considerable erosion of the subglacial bedrock. The erosion is revealed by ice-penetrating radar measurements, and now exerts a geometric control on ice sheet streaming in the eroded region, and possibly the overall geometry of the GIS. Anderson, K. K., et al. (2004), High-resolution record of Northern Hemisphere climate extending into the last interglacial period, Nature, 431(7005), 147-151 Fahnestock, M., W. Abdalati, I. Joughin, J. Brozena, and P. Gogineni (2001), High geothermal heat flow, basal melt, and the origin of rapid ice flow in central Greenland, Science, 294, 2338-2342

  7. The use of web-based learning for simulation-based education and training of central venous catheterization in novice learners.

    PubMed

    Cheung, Jeffrey J H; Koh, Jansen; Mackinnon, Kim; Brett, Clare; Bgli, Darius; Kapralos, Bill; Dubrowski, Adam

    2013-01-01

    Both simulation-based education and training (SBET) and Web-based Learning (WBL) are increasingly used in medical education. We developed a Web-based learning course on "Observational Practice and Educational Networking" (OPEN), to augment SBET for central venous catheterization (CVC), a complex clinical skill, for novice learners. This pilot study aimed to firstly, understand the perspectives of novice learners on using WBL in preparation for SBET for a psychomotor skill and secondly, to observe how learners use the OPEN courseware to learn more about how to perform this skill. PMID:23400133

  8. Conservation action based on threatened species capture taxonomic and phylogenetic richness in breeding and wintering populations of Central Asian birds.

    PubMed

    Schweizer, Manuel; Ay, Raffael; Kashkarov, Roman; Roth, Tobias

    2014-01-01

    Although phylogenetic diversity has been suggested to be relevant from a conservation point of view, its role is still limited in applied nature conservation. Recently, the practice of investing conservation resources based on threatened species was identified as a reason for the slow integration of phylogenetic diversity in nature conservation planning. One of the main arguments is based on the observation that threatened species are not evenly distributed over the phylogenetic tree. However this argument seems to dismiss the fact that conservation action is a spatially explicit process, and even if threatened species are not evenly distributed over the phylogenetic tree, the occurrence of threatened species could still indicate areas with above average phylogenetic diversity and consequently could protect phylogenetic diversity. Here we aim to study the selection of important bird areas in Central Asia, which were nominated largely based on the presence of threatened bird species. We show that although threatened species occurring in Central Asia do not capture phylogenetically more distinct species than expected by chance, the current spatially explicit conservation approach of selecting important bird areas covers above average taxonomic and phylogenetic diversity of breeding and wintering birds. We conclude that the spatially explicit processes of conservation actions need to be considered in the current discussion of whether new prioritization methods are needed to complement conservation action based on threatened species. PMID:25337861

  9. Conservation Action Based on Threatened Species Capture Taxonomic and Phylogenetic Richness in Breeding and Wintering Populations of Central Asian Birds

    PubMed Central

    Schweizer, Manuel; Ayé, Raffael; Kashkarov, Roman; Roth, Tobias

    2014-01-01

    Although phylogenetic diversity has been suggested to be relevant from a conservation point of view, its role is still limited in applied nature conservation. Recently, the practice of investing conservation resources based on threatened species was identified as a reason for the slow integration of phylogenetic diversity in nature conservation planning. One of the main arguments is based on the observation that threatened species are not evenly distributed over the phylogenetic tree. However this argument seems to dismiss the fact that conservation action is a spatially explicit process, and even if threatened species are not evenly distributed over the phylogenetic tree, the occurrence of threatened species could still indicate areas with above average phylogenetic diversity and consequently could protect phylogenetic diversity. Here we aim to study the selection of important bird areas in Central Asia, which were nominated largely based on the presence of threatened bird species. We show that although threatened species occurring in Central Asia do not capture phylogenetically more distinct species than expected by chance, the current spatially explicit conservation approach of selecting important bird areas covers above average taxonomic and phylogenetic diversity of breeding and wintering birds. We conclude that the spatially explicit processes of conservation actions need to be considered in the current discussion of whether new prioritization methods are needed to complement conservation action based on threatened species. PMID:25337861

  10. Peripherally inserted central catheter: compliance with evidence-based indications for insertion in an inpatient setting.

    PubMed

    Wojnar, Danuta G; Beaman, Margaret L

    2013-01-01

    A randomized, retrospective chart review was conducted at a medium-sized community hospital to verify appropriateness of peripherally inserted central catheter (PICC) use in 49 inpatient patients. Study results support the Infusion Nurses Society recommendation to use PICCs to facilitate either short- or long-term intravenous therapy of vesicants, irritants, and any medications with a pH less than 5 or greater than 9 and osmolarity greater than 600 mOsm/L. All PICC insertion criteria recommended by the Centers for Disease Control and Prevention were met except one--the intended duration of intravenous therapy of more than 6 days. Identical PICC selection criteria are needed to standardize clinical practice. PMID:23823005

  11. Unnatural base pair systems toward the expansion of the genetic alphabet in the central dogma.

    PubMed

    Hirao, Ichiro; Kimoto, Michiko

    2012-01-01

    Toward the expansion of the genetic alphabet of DNA, several artificial third base pairs (unnatural base pairs) have been created. Synthetic DNAs containing the unnatural base pairs can be amplified faithfully by PCR, along with the natural A-T and G-C pairs, and transcribed into RNA. The unnatural base pair systems now have high potential to open the door to next generation biotechnology. The creation of unnatural base pairs is a consequence of repeating "proof of concept" experiments. In the process, initially designed base pairs were modified to address their weak points. Some of them were artificially evolved to ones with higher efficiency and selectivity in polymerase reactions, while others were eliminated from the analysis. Here, we describe the process of unnatural base pair development, as well as the tests of their applications. PMID:22850726

  12. Sustainability and Cost of a Community-Based Strategy Against Aedes aegypti in Northern and Central Vietnam

    PubMed Central

    Kay, Brian H.; Tuyet Hanh, Tran T.; Le, Nguyen Hoang; Quy, Tran Minh; Nam, Vu Sinh; Hang, Phan V. D.; Yen, Nguyen Thi; Hill, Peter S.; Vos, Theo; Ryan, Peter A.

    2010-01-01

    We previously reported a new community-based mosquito control that resulted in the elimination of Aedes aegypti in 40 of 46 communes in northern and central Vietnam. During 2007 and 2008, we revisited Nam Dinh and Khanh Hoa provinces in northern and central Vietnam, respectively, to evaluate whether or not these programs were still being maintained 7 years and 4.5 years after formal project activities had ceased, respectively. Using a previously published sustainability framework, we compared 13 criteria from Tho Nghiep commune in Nam Dinh where the local community had adopted our community-based project model using Mesocyclops from 2001. These data were compared against a formal project commune, Xuan Phong, where our successful intervention activities had ceased in 2000 and four communes operating under the National Dengue Control Program with data available. In Khanh Hoa province, we compared 2008 data at Ninh Xuan commune with data at project completion in 2003 and benchmarked these, where possible, against an untreated control commune, Ninh Binh, where few control activities had been undertaken. The three communes where the above community-based strategy had been adopted were rated as well-sustained with annual recurrent total costs (direct and indirect) of $0.280.89 international dollars per person. PMID:20439962

  13. A new map of the vegetation of central European Russia based on high-resolution satellite data.

    PubMed

    Ershov, D V; Gavrilyuk, E A; Karpukhina, D A; Kovganko, K A

    2015-09-01

    The scientific basis of and approaches to regional thematic mapping of vegetation based on high-resolution satellite data have been elaborated. A vegetation map of central European Russia has been compiled. The map includes 12 thematic classes, six of which pertain to forest ecosystems. The map has been compared to the data of the GFC project (University of Maryland, United States) and the official data of the Rosstat Federal Service of State Statistics (Russia). The new vegetation map is currently used in the information system of the remote monitoring of forest fires in Russia. PMID:26530069

  14. Exploring a type of central pattern generator based on Hindmarsh-Rose model: from theory to application.

    PubMed

    Zhang, Dingguo; Zhang, Qing; Zhu, Xiangyang

    2015-02-01

    This paper proposes the idea that Hindmarsh-Rose (HR) neuronal model can be used to develop a new type of central pattern generator (CPG). Some key properties of HR model are studied and proved to meet the requirements of CPG. Pros and cons of HR model are provided. A CPG network based on HR model is developed and the related properties are investigated. We explore the bipedal primary gaits generated by the CPG network. The preliminary applications of HR model are tested on humanoid locomotion model and functional electrical stimulation (FES) walking system. The positive results of stimulation and experiment show the feasibility of HR model as a valid CPG. PMID:25146328

  15. Soil erosion history in central Tanzania based on OSL dating of colluvial and alluvial hillslope deposits

    NASA Astrophysics Data System (ADS)

    Eriksson, M. G.; Olley, J. M.; Payton, R. W.

    2000-12-01

    The Irangi Hills in Kondoa District, central Tanzania, are severely degraded by sheet, rill and gully erosion. Using recently developed optically stimulated luminescence (OSL) dating techniques, and a detailed study of the hillslope stratigraphy and soils, we have determined the sequence of events that gave rise to this highly degraded landscape. Two major colluvial deposits have been identified on the slopes. The oldest colluvium gave OSL deposition dates of 14,7001600, 14,2001500 and 11,4001300 years ago. These dates coincide with the climatic change from dry to wet conditions, which took place during the Late Pleistocene. It is possible that the erosion and deposition of the old colluvium occurred as a response to this change. This phase of erosion and deposition was followed by a long phase of stability and pedogenetic alteration of the old colluvium. A phase of accelerated soil erosion began not later than 900 years ago, as indicated by a dated alluvial fan, the presence of which indicates that some deeper gullies already existed on upper pediment slopes at that time. The second, more recent colluvial deposit gave OSL dates of 46040, 59070 and 66050 years. A major period of gully formation and incision, with subsequent fan development, occurred sometime between 600 and 300 years ago. The recent phase of erosion (<1000 years), which is still continuing, is probably a result of the introduction and/or intensification of agriculture, livestock husbandry and iron smelting practices in the Irangi Hills.

  16. Kinematics of the New Madrid seismic zone, central United States, based on stepover models

    USGS Publications Warehouse

    Pratt, Thomas L.

    2012-01-01

    Seismicity in the New Madrid seismic zone (NMSZ) of the central United States is generally attributed to a stepover structure in which the Reelfoot thrust fault transfers slip between parallel strike-slip faults. However, some arms of the seismic zone do not fit this simple model. Comparison of the NMSZ with an analog sandbox model of a restraining stepover structure explains all of the arms of seismicity as only part of the extensive pattern of faults that characterizes stepover structures. Computer models show that the stepover structure may form because differences in the trends of lower crustal shearing and inherited upper crustal faults make a step between en echelon fault segments the easiest path for slip in the upper crust. The models predict that the modern seismicity occurs only on a subset of the faults in the New Madrid stepover structure, that only the southern part of the stepover structure ruptured in the A.D. 18111812 earthquakes, and that the stepover formed because the trends of older faults are not the same as the current direction of shearing.

  17. An observationally based evaluation of WRF seasonal simulations over the Central and Eastern Pacific

    NASA Astrophysics Data System (ADS)

    Wu, Longtao; Li, J.-L. F.; Pi, Chia-Jung; Yu, Jia-Yuh; Chen, Jen-Ping

    2015-10-01

    This study uses multiple satellite data sets to evaluate seasonal simulations of the Weather Research and Forecasting (WRF) model over Central and Eastern Pacific. Experiments with five different convective parameterizations all show reasonably good performance for precipitation simulations. However, large discrepancies exist in the model-simulated ice clouds compared to CloudSat observations. Underestimations of ice clouds, mainly snow and graupel, are present in the Intertropical Convergence Zone (ITCZ) in all the experiments compared to CloudSat. In the ITCZ, all the experiments show a systematic overestimation of outgoing longwave radiation at the top of the atmosphere and downward shortwave radiation at the surface, along with biased cloud cooling in the middle and upper troposphere and biased cloud warming in the lower troposphere. Vertical motion is enhanced in the ITCZ compared to reanalysis. A weaker low-level circulation over the midlatitude oceans is evidenced in all simulations with an eastward overextension of the South Pacific Convergence Zone and overestimated moisture over the Southern Hemisphere oceans when compared to Special Sensor Microwave/Imager observations. Sensitivity experiment demonstrates that doubling the radiative effect of snow can reduce high biases in vertical motion within the ITCZ and improve the large-scale circulation and moisture over the midlatitude oceans.

  18. Centralized Monitoring of the Microsoft Windows-based computers of the LHC Experiment Control Systems

    NASA Astrophysics Data System (ADS)

    Varela Rodriguez, F.

    2011-12-01

    The control system of each of the four major Experiments at the CERN Large Hadron Collider (LHC) is distributed over up to 160 computers running either Linux or Microsoft Windows. A quick response to abnormal situations of the computer infrastructure is crucial to maximize the physics usage. For this reason, a tool was developed to supervise, identify errors and troubleshoot such a large system. Although the monitoring of the performance of the Linux computers and their processes was available since the first versions of the tool, it is only recently that the software package has been extended to provide similar functionality for the nodes running Microsoft Windows as this platform is the most commonly used in the LHC detector control systems. In this paper, the architecture and the functionality of the Windows Management Instrumentation (WMI) client developed to provide centralized monitoring of the nodes running different flavour of the Microsoft platform, as well as the interface to the SCADA software of the control systems are presented. The tool is currently being commissioned by the Experiments and it has already proven to be very efficient optimize the running systems and to detect misbehaving processes or nodes.

  19. The beaver Anchitheriomys from the Miocene of Central Europe

    SciTech Connect

    Stefen, C.; Mors, T.

    2008-09-15

    New finds of teeth and mandibles of Anchitheriomys from the Hambach opencast lignite mine in Northwest Germany and the first detailed descriptions of other mandibles from South Germany and Switzerland allow a review of the Central European specimens of this rare beaver genus. The metric variation of cheek teeth and especially the great differences in dimensions of incisors can be much better assessed. The observed range in size can be attributed to ontogenetic changes, and all material is assigned to Anchitheriomys suevicus. Stratigraphically, this species is restricted to the early middle Miocene, European Mammalian Neogene biozones MN 5-6.

  20. Combined use of miniscrews and continuous arch for intrusive root movement of incisors in Class II division 2 with gummy smile.

    PubMed

    Kim, Sung-Jin; Kim, Jin-Wook; Choi, Tae-Hyun; Lee, Kee-Joon

    2014-09-01

    Adequate intrusion and torque control of the retroclined maxillary incisors are critical for the treatment of Class II division 2 (div2) malocclusion. In addition, anterior retraction via lingual root movement can be challenging. This case report demonstrates a combined use of miniscrews and continuous arch with additional torque for intrusion, retraction, and torque control of maxillary incisors in the Class II div2 with gummy smile. A 20-year-old woman presented with multiple issues, including impacted canine, lip protrusion, prolonged retained mandibular primary molar, and two missing maxillary premolars. In order to improve her facial profile and eliminate the need for prosthetic work, the mandibular primary molar and contralateral premolar were extracted. Two miniscrews were placed at the maxillary buccal alveolar bone to apply the posterosuperior force for retraction of anterior teeth, with additional labial crown torque on the arch wire. The results were the intrusion (4 mm) and lingual root movement (17) of the maxillary incisors without anchorage loss of maxillary molars, flattening of the Curve of Spee, and Class I molar relation that were maintained after 50 months of retention period. The combined use of miniscrews and continuous arch could be a reliable and effective treatment modality for torque control and intrusion of retroclined maxillary incisors in the Class II div2 patient. PMID:24512532

  1. Indoor Mobile Robot Navigation by Central Following Based on Monocular Vision

    NASA Astrophysics Data System (ADS)

    Saitoh, Takeshi; Tada, Naoya; Konishi, Ryosuke

    This paper develops the indoor mobile robot navigation by center following based on monocular vision. In our method, based on the frontal image, two boundary lines between the wall and baseboard are detected. Then, the appearance based obstacle detection is applied. When the obstacle exists, the avoidance or stop movement is worked according to the size and position of the obstacle, and when the obstacle does not exist, the robot moves at the center of the corridor. We developed the wheelchair based mobile robot. We estimated the accuracy of the boundary line detection, and obtained fast processing speed and high detection accuracy. We demonstrate the effectiveness of our mobile robot by the stopping experiments with various obstacles and moving experiments.

  2. Maxillary fixed prosthesis design based on the preoperative physical examination.

    PubMed

    Block, Michael S

    2015-05-01

    The purpose of this article is to illustrate the use of physical examination findings that can be used to determine the design characteristics of a full arch restoration in the maxilla. These anatomic findings include 1) the resting and 2) smile line exposures of the central incisor; 3) the vertical position of the edentulous ridge when smiling; 4) the anteroposterior relation of the teeth to the edentulous ridge; 5) the presence of bone posterior to the premolar region; 6) the anterior height of the alveolar bone in relation to the floor of the nose; and 7) the planned inclination of the maxillary teeth. Based on these physical findings, the final prosthetic plan can be established before surgery. Determination of the final restorative plan determines the surgical procedures to be performed. PMID:25659360

  3. The central role of chloride in the metabolic acid-base changes in canine parvoviral enteritis.

    PubMed

    Burchell, Richard K; Schoeman, Johan P; Leisewitz, Andrew L

    2014-04-01

    The acid-base disturbances in canine parvoviral (CPV) enteritis are not well described. In addition, the mechanisms causing these perturbations have not been fully elucidated. The purpose of the present study was to assess acid-base changes in puppies suffering from CPV enteritis, using a modified strong ion model (SIM). The hypothesis of the study was that severe acid-base disturbances would be present and that the SIM would provide insights into pathological mechanisms, which have not been fully appreciated by the Henderson-Hasselbalch model. The study analysed retrospective data, obtained from 42 puppies with confirmed CPV enteritis and 10 healthy control dogs. The CPV-enteritis group had been allocated a clinical score, to allow classification of the data according to clinical severity. The effects of changes in free water, chloride, l-lactate, albumin and phosphate were calculated, using a modification of the base excess algorithm. When the data were summated for each patient, and correlated to each individual component, the most important contributor to the metabolic acid-base changes, according to the SIM, was chloride (P<0.001). Severely-affected animals tended to demonstrate hypochloraemic alkalosis, whereas mildly-affected puppies had a hyperchloraemic acidosis (P=0.007). In conclusion, the acid-base disturbances in CPV enteritis are multifactorial and complex, with the SIM providing information in terms of the origin of these changes. PMID:24613416

  4. Imaging central skull base neural tumor spread from paranasal sinus malignancies: a critical factor in treatment planning.

    PubMed

    Som, P M; Costantino, P D; Silvers, A R

    1999-01-01

    Eight cases of paranasal sinus tumors with central skull base disease are presented. Each patient had coned down noncontrast and contrast-enhanced magnetic resonance imaging (MRI) studies to evaluate the tumor margins and any potential tumor spread into the cavernous sinuses, V2 and the Vidian nerve. Two patients had tumors that extended up to the face of the sphenoid bone and one had a tumor in the ventral cavernous sinus. These three patients had a complete tumor resection with postoperative irradiation. Two more patients had extensive tumor invasion of the central skull base, one was treated with only irradiation, one refused treatment. Three more patients had tumors that involved the ventral portion of the sphenoid bone with limited neural tumor extension. Two of these patients had surgery with cavernous sinus dissections followed by irradiation. One patient delayed treatment for 2 months and when he returned he had a more extensive tumor and was considered incurable by surgery. He refused further treatment. The technique of the focused MR examination and its impact on treatment planning is discussed. PMID:17171077

  5. How central and connected am I in my family? Family-based social capital of individuals with intellectual disability.

    PubMed

    Widmer, E D; Kempf-Constantin, N; Robert-Tissot, C; Lanzi, F; Carminati, G Galli

    2008-01-01

    Using social network methods, this article explores the ways in which individuals with intellectual disability (ID) perceive their family contexts and the social capital that they provide. Based on a subsample of 24 individuals with ID, a subsample of 24 individuals with ID and psychiatric disorders, and a control sample of 24 pre-graduate and postgraduate students matched to the clinical respondents for age and sex, we found that family networks of clinical individuals are distinct both in terms of composition and in terms of social capital made available to them by their family ties. Individuals with ID perceive themselves as less central in their own family; their family networks are perceived as less dense, less centralized, and more disconnected. Individuals with intellectual disabilities and psychiatric disorders have less family-based social capital than individuals with intellectual disabilities only. The composition of their family is also distinct as spouses or partners and children are missing. We discuss the importance of those findings for research on family relationships of individuals with ID. PMID:17383854

  6. The regime of aerosol optical depth over Central Asia based on MODIS Aqua Deep Blue data

    NASA Astrophysics Data System (ADS)

    Floutsi, Athina; KorrasCarraca, Marios; Matsoukas, Christos; Biskos, George

    2015-04-01

    Atmospheric aerosols, both natural and anthropogenic, can affect the regional and global climate through their direct, indirect, and semi-direct effects on the radiative energy budget of the Earth-atmosphere system. To quantify these effects it is therefore important to determine the aerosol load, and an effective way to do that is by measuring the aerosol optical depth (AOD). In this study we investigate the spatial and temporal variability of the AOD over the climatically sensitive region of Central Asia (36° N - 50° N, 46° E - 75° E), which has significant sources of both natural and anthropogenic particles. The primary source of anthropogenic particles is fossil fuel combustion occurring mainly at oil refineries in the Caspian Sea basin. Natural particles originate mostly from the two deserts in the region (namely Kara-Kum and Kyzyl-Kum), where persistent dust activity is observed. Another source is the Aral Sea region, which due to its phenomenal desertification also drives an intense salt and dust transport from the exposed sea-bed to the surrounding regions. This transport is of particular interest because of health-hazardous materials contained in the Aral Sea sea-bed. For our analysis we use Level-3 daily MODIS - Aqua Dark Target - Deep Blue combined product, from the latest MODIS collection (006), available in 1° x 1° resolution (about 100 km x 100 km) over the period 2002-2014.Our first results indicate a significant spatial variability of the aerosol load over the study region. The data also show a clear seasonal cycle, with large aerosol load being associated with strong dust activity during spring and summer (AOD up to 0.5), and low during autumn and winter (AOD up to 0.4). In spring and summer significant aerosol load is observed in the Garabogazköl basin, Northeast and South-southeast Caspian Sea (offshore North Iran and Azerbaijan), as well as southwest of the Aral Sea. In the later region, the high AOD values can be explained by export of dust from the exposed sea-bed under strong northerly and north-easterly winds, and was found to be slightly larger during summer. From this analysis we have excluded the Aral Sea, over which the AOD values were extreme (up to 2.1 and 1.3 during July and January, respectively). The AOD exhibits statistically-significant increasing trend, with an ~40% mean regional relative change. The changes over are more pronounced over and around the Aral Sea, and are stronger during the warm period of the year (April to September). Our results suggest that these trends are associated with increased dust transport from the exposed Aral Sea sea-bed during the study period, which will be examined with the trends of the frequency and strength of aerosol events over central Asia, as well as their association with the Aral Sea desertification.

  7. Paleoecology and Paleoclimate of Tanjung Formation Deposition, Based on Palynological Data From Siung Malopot, Central Borneo

    NASA Astrophysics Data System (ADS)

    Kristyarin, D. A.; Rahardjo, A. T.; Bambang, P.

    2016-01-01

    The northern part of Barito basin is exposed around Siung Malopot area (Central Kalimantan), showing the late cretaceous basement of andesite lavas and granite intrusion. The basement is unconformably overlied by the rocks of Tanjung formation at middle to late Eocene age. Compressive phase during Miocene and Plio-Pleistocene folded and uplifted all existing rocks, made the rocks become relatively north-south structurally oriented. The exposed Tanjung formation consists of sandstone, mudstone, siltstone with intercalation of coals and thin layers of limestone. These lithologies may represent the upper parts of Tanjung formation. Palynology quantitative study is an approach to identify the palaeoclimate and palaeoecology of a certain sedimentation system. Analyses from 18 samples taken from lithologies of Tanjung formation show the presence of palinomorph fossils associated in Proxapertites operculatus zonation indicating the P18-P20 age intervals, or late eocene age. The ratio of spore and non-spore percentage, as well as the comparison between arboreal pollen (AP) and non-arboreal pollen (NAP) show the significant change of environment from time to time during the deposition of the Tanjung formation, also indicating the climate humidity that became more stabile to the younger ages. From 52 observed taxa in the samples, the ratio of marine versus non-marine taxon indicates the influence of sea-water influx in the sedimentation system, explaining the possible presence of thin limestone intercalations at the upper parts of Tanjung formation. Palynology quantitative study on Tanjung Formation indicates the sedimentation of this formation was in backmangrove environment that tends to become more influenced by marine conditions.

  8. Landslide observation and volume estimation in central Georgia based on L-band InSAR

    NASA Astrophysics Data System (ADS)

    Nikolaeva, E.; Walter, T. R.; Shirzaei, M.; Zschau, J.

    2014-03-01

    The republic of Georgia is a mountainous and tectonically active area that is vulnerable to landslides. Because landslides are one of the most devastating natural hazards, their detection and monitoring is of great importance. In this study we report on a previously unknown landslide in central Georgia near the town of Sachkhere. We used a set of Advanced Land Observation Satellite (ALOS) Phased Array type L-band Synthetic Aperture Radar (PALSAR) data to generate displacement maps using interferometric synthetic aperture radar (InSAR). We detected a sliding zone of dimensions 2 km north-south by 0.6 km east-west that threatens four villages. We estimated surface displacement of up to ∼30 cm/yr over the sliding body in the satellite line-of-sight (LOS) direction, with the largest displacement occurring after a local tectonic earthquake. We mapped the morphology of the landslide mass by aerial photography and field surveying. We found a complex set of interacting processes, including surface fracturing, shear and normal faults at both the headwall and the sides of the landslide, local landslide velocity changes, earthquake-induced velocity peaks, and loss in toe support due to mining activity. Important implications that are applicable elsewhere can be drawn from this study of coupled processes. We used inverse dislocation modelling to find a possible dislocation plane resembling the landslide basal décollement, and we used that plane to calculate the volume of the landslide. The results suggest a décollement at ∼120 m depth, dipping at ∼10° sub-parallel to the surface, which is indicative of a translational-type landslide.

  9. The Generation of Antiphase Oscillations and Synchrony by a Rebound-Based Vertebrate Central Pattern Generator

    PubMed Central

    Merrison-Hort, Robert; Zhang, Hong-Yan; Borisyuk, Roman

    2014-01-01

    Many neural circuits are capable of generating multiple stereotyped outputs after different sensory inputs or neuromodulation. We have previously identified the central pattern generator (CPG) for Xenopus tadpole swimming that involves antiphase oscillations of activity between the left and right sides. Here we analyze the cellular basis for spontaneous left–right motor synchrony characterized by simultaneous bursting on both sides at twice the swimming frequency. Spontaneous synchrony bouts are rare in most tadpoles, and they instantly emerge from and switch back to swimming, most frequently within the first second after skin stimulation. Analyses show that only neurons that are active during swimming fire action potentials in synchrony, suggesting both output patterns derive from the same neural circuit. The firing of excitatory descending interneurons (dINs) leads that of other types of neurons in synchrony as it does in swimming. During synchrony, the time window between phasic excitation and inhibition is 7.9 ± 1 ms, shorter than that in swimming (41 ± 2.3 ms). The occasional, extra midcycle firing of dINs during swimming may initiate synchrony, and mismatches of timing in the left and right activity can switch synchrony back to swimming. Computer modeling supports these findings by showing that the same neural network, in which reciprocal inhibition mediates rebound firing, can generate both swimming and synchrony without circuit reconfiguration. Modeling also shows that lengthening the time window between phasic excitation and inhibition by increasing dIN synaptic/conduction delay can improve the stability of synchrony. PMID:24760866

  10. Magmatic occurrences in the Central Arava (southern Israel) based on Geology and Magnetometry

    NASA Astrophysics Data System (ADS)

    Hanan, Ginat; Michael, Rybakov; Boris, Shirman; Michael, Lazar

    2014-05-01

    The Eshet Ridge is located in the Central Arava near Wadi Paran. Geological data were collected using ground magnetic surveys and petrophysical measurements (magnetic susceptibility and density). The goal was to reveal the structure and nature of a concealed magmatic body under the ridge. Integrated gravity and magnetic interpretation together with seismic reflection data (including 2 modeling) indicated the presence of a deep-seated basic magmatic intrusion. Occurrence of Fe-mineralized rocks along the ridge supports subsurface data. The magmatic body was intruded in the hard Turonian rocks of the Eshet Ridge. Basic magmatic exposures dating from the Early Miocene were evident along Wadi Ashosh (in the eastern Negev) and its margins 18 km. to the north of the ridge. A new outcrop of basic magmatic intrusion was found southwest of the Tzukim settlement. Magnetic measurements indicated a similarity between their magnetic pattern and the Ashosh basic magmatics, which were dated to 20.4 0.7 Ma. Volcanoclastic tuff pebbles (magnetic susceptibility of around 2-7 * 10-3 SI) surrounded by conglomerate were discovered at two sites in Wadi Demma and Wadi Menuha (streams that drain near the Eshet Ridge and 2 km south of it, respectively). The conglomerates contained mostly limestone, chalk and chert fragments; not more than 5% of which were volcanic pebbles. Two pebbles were dated to 24.4 0.7and 21.5 0.5 Ma. The magmatic outcrops in Wadi Ashosh, the magmatic dyke near Tzukim and the volcanic purple and black pebbles near Wadi Menuha were all dated to the very Late Oligocene-Early Miocene. The magmatic body identified in this study under the Eshet Ridge was termed the Eshet Intrusion and is connected to, and even the source of, all these phenomena.

  11. Response of the incisor tooth to 2,3,7,8-tetrachlorodibenzo-p-dioxin in a dioxin-resistant and a dioxin-sensitive rat strain.

    PubMed

    Kiukkonen, Anu; Viluksela, Matti; Sahlberg, Carin; Alaluusua, Satu; Tuomisto, Jouni T; Tuomisto, Jouko; Lukinmaa, Pirjo-Liisa

    2002-10-01

    Dioxins are ubiquitous environmental pollutants that afflict developing teeth. To find out if the effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on the continuously erupting rat incisor is associated with the sensitivity to TCDD acute lethality and to see the histological basis for any macroscopic findings, we exposed 25 resistant Han/Wistar (Kuopio; H/W) and 20 sensitive Long-Evans (Turku/AB; L-E) female rats to total doses of 0.17, 1.7, 17, and 170 (only H/W rats) micro g/kg TCDD. Each dose group comprised five animals. The treatment was started when the rats were 10 weeks old and continued for 20 weeks. The exposure time covered two life cycles of the incisor. Stereomicroscopic examination of the dissected mandibles showed color defects and pulpal perforation of the lower incisors at 17 and 170 micro g/kg TCDD. Tissue sections revealed odontoblastic and pulpal cell death and the consequent arrest of dentin formation at the incisal tooth end at the same doses. H/W rat incisors were affected closer to the germinative tooth end at 170 than at 17 micro g/kg TCDD, resulting in a larger perforation. In accordance with the enamel discoloration, the postsecretory enamel organ underwent, albeit inconsistently, precocious squamous metaplasia with pronounced proliferation. Thus, both the mesenchymal and, to a lesser extent, epithelial elements of the forming tooth were affected dose-dependently at relatively high doses of TCDD. Similar responses in both strains implied that the impaired formation of the incisor tooth, at least of its mesenchymal elements, is not associated with the differential resistance of H/W and L-E rats to TCDD acute lethality. PMID:12377997

  12. A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streams (Final Report)

    EPA Science Inventory

    Cover of the Field-<span class=Based Aquatic Life Benchmark for Conductivity ...

  13. PROPERLY MANAGED FORAGE-BASED COW-CALF OPERATIONS IN SOUTH CENTRAL FLORIDA ARE ENVIRONMENTALLY FRIENDLY

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soil P levels in subtropical forage-based beef cattle pastures with BG and RP-G declined from 1988 to 2004. During the past 15 years, there was no build up of Mehlich-1 extractable soil P and other crop nutrients despite annual N and P fertilization. Soil testing of pastures in the subtropics is vi...

  14. A Field-Based Aquatic Life Benchmark for Conductivity in Central Appalachian Streams (Final Report)

    EPA Science Inventory

    Cover of the Field-<span class=Based Aquatic Life Benchmark for Conductivity ...

  15. Spatial point analysis based on dengue surveys at household level in central Brazil

    PubMed Central

    Siqueira-Junior, Joo B; Maciel, Ivan J; Barcellos, Christovam; Souza, Wayner V; Carvalho, Marilia S; Nascimento, Nazareth E; Oliveira, Renato M; Morais-Neto, Otaliba; Martelli, Celina MT

    2008-01-01

    Background Dengue virus (DENV) affects nonimunne human populations in tropical and subtropical regions. In the Americas, dengue has drastically increased in the last two decades and Brazil is considered one of the most affected countries. The high frequency of asymptomatic infection makes difficult to estimate prevalence of infection using registered cases and to locate high risk intra-urban area at population level. The goal of this spatial point analysis was to identify potential high-risk intra-urban areas of dengue, using data collected at household level from surveys. Methods Two household surveys took place in the city of Goiania (~1.1 million population), Central Brazil in the year 2001 and 2002. First survey screened 1,586 asymptomatic individuals older than 5 years of age. Second survey 2,906 asymptomatic volunteers, same age-groups, were selected by multistage sampling (census tracts; blocks; households) using available digital maps. Sera from participants were tested by dengue virus-specific IgM/IgG by EIA. A Generalized Additive Model (GAM) was used to detect the spatial varying risk over the region. Initially without any fixed covariates, to depict the overall risk map, followed by a model including the main covariates and the year, where the resulting maps show the risk associated with living place, controlled for the individual risk factors. This method has the advantage to generate smoothed risk factors maps, adjusted by socio-demographic covariates. Results The prevalence of antibody against dengue infection was 37.3% (95%CI [35.539.1]) in the year 2002; 7.8% increase in one-year interval. The spatial variation in risk of dengue infection significantly changed when comparing 2001 with 2002, (ORadjusted = 1.35; p < 0.001), while controlling for potential confounders using GAM model. Also increasing age and low education levels were associated with dengue infection. Conclusion This study showed spatial heterogeneity in the risk areas of dengue when using a spatial multivariate approach in a short time interval. Data from household surveys pointed out that low prevalence areas in 2001 surveys shifted to high-risk area in consecutive year. This mapping of dengue risks should give insights for control interventions in urban areas. PMID:18937868

  16. Knowledge-Based, Central Nervous System (CNS) Lead Selection and Lead Optimization for CNS Drug Discovery

    PubMed Central

    2011-01-01

    The central nervous system (CNS) is the major area that is affected by aging. Alzheimers disease (AD), Parkinsons disease (PD), brain cancer, and stroke are the CNS diseases that will cost trillions of dollars for their treatment. Achievement of appropriate bloodbrain barrier (BBB) penetration is often considered a significant hurdle in the CNS drug discovery process. On the other hand, BBB penetration may be a liability for many of the non-CNS drug targets, and a clear understanding of the physicochemical and structural differences between CNS and non-CNS drugs may assist both research areas. Because of the numerous and challenging issues in CNS drug discovery and the low success rates, pharmaceutical companies are beginning to deprioritize their drug discovery efforts in the CNS arena. Prompted by these challenges and to aid in the design of high-quality, efficacious CNS compounds, we analyzed the physicochemical property and the chemical structural profiles of 317 CNS and 626 non-CNS oral drugs. The conclusions derived provide an ideal property profile for lead selection and the property modification strategy during the lead optimization process. A list of substructural units that may be useful for CNS drug design was also provided here. A classification tree was also developed to differentiate between CNS drugs and non-CNS oral drugs. The combined analysis provided the following guidelines for designing high-quality CNS drugs: (i) topological molecular polar surface area of <76 2 (2560 2), (ii) at least one (one or two, including one aliphatic amine) nitrogen, (iii) fewer than seven (two to four) linear chains outside of rings, (iv) fewer than three (zero or one) polar hydrogen atoms, (v) volume of 740970 3, (vi) solvent accessible surface area of 460580 2, and (vii) positive QikProp parameter CNS. The ranges within parentheses may be used during lead optimization. One violation to this proposed profile may be acceptable. The chemoinformatics approaches for graphically analyzing multiple properties efficiently are presented. PMID:22267984

  17. Provenance of the Subinal Formation, Central Guatemala, Based on Point-Counting of Pebbles in Conglomerates

    NASA Astrophysics Data System (ADS)

    Gutierrez, A.; Martens, U.

    2007-05-01

    The continental Subinal Formation of Central Guatemala is composed of red conglomerates and sandstones that outcrop in the Motagua valley between the San Agustn and Cabaas fault, and in the southeastern corner of Guatemala. Stratigraphic position implies a post-Cretaceous depositional age, which has not been accurately established. Point counts of pebbles in conglomerates were performed in localities distributed along the Motagua valley from Granados to Los Amates, and in the Jocotn-Esquipulas area near the border with Honduras. Pebble types contained in conglomerates in the Motagua area are very diverse, and include sandstones, limestones, chert, milky quartz, phyllite, marble, chlorite schist, quartz-muscovite schist, amphibolite, eclogite, gneiss, granite, gabbro/diorite, volcanic rocks, and abundant serpentinite. Schist and gneiss resembles rocks of the Chuacs complex. Serpentinite, gabbro, amphibolite, and eclogite clasts are similar to oceanic lithosphere from the Motagua suture. Abundant white mica in interbedded sandstones is ubiquitous, suggesting derivation from the mica-rich Chuacs complex. Unfoliated granites and volcanic clasts were probably derived from the northern edge of the Chortis block or an unknown terrane, as no unmetamorphosed igneous rocks are known from the southern edge of the Maya block. The relative abundance of some clast groups correlates with the rock units exposed immediately adjacent to the north across the San Agustn fault. Serpentinite in conglomerate is most abundant near Juan de Paz; eclogite, amphibolite and gneiss are most abundant in the Granados area; and white mica is most abundant where Chuacs complex schists are most pelitic. This suggests that the Cabaas fault accommodated most of the strike-slip movement of the Motagua fault system. In contrast, conglomerates in southeastern Guatemala are more homogeneous, containing chiefly clasts of volcanic origin, with minor limestone, graphitic phyllite, chert, and milky quartz. Pebbles were probably derived from the underlying Padre Miguel volcanics that occur within the Chortis block, not from rock units in the Motagua suture zone. Pebbles contained in red beds in the Motagua valley were derived from rock units of the Motagua suture and the southern margin of the Maya block, but provenance from rock of the Chortis block is not clear. These findings suggest that red-bed-bearing basins in the Motagua valley and in the southeast of Guatemala were not connected, and may have formed at disparate times.

  18. Proxy-based reconstructions of earthquakes and tsunamis over the past millennia, Quidico, central Chile

    NASA Astrophysics Data System (ADS)

    Hong, I.; Ely, L. L.; Horton, B.; Dura, T.; Cisternas, M.

    2013-12-01

    We utilized geomorphic, sedimentological, and stratigraphic methods to describe the relative magnitude of historic tsunamis and better understand the paleoseismic history at Quidico, Chile (38.1 S, 73.2 W). The study site lies within the transition zone between two major subduction-zone earthquake events during the observational period: the great 1960 Mw 9.5 earthquake to the south and the 2010 Mw 8.8 Maule earthquake to the north. Despite Chile's growing need to continue to refine earthquake and tsunami hazards, there are few studies aimed at quantifying the geologic impact of earthquake-rupture overlap through time in this region. A combination of pits, cores, and riverbank exposures provide stratigraphic evidence of 5, laterally-continuous sand layers within the Quidico River floodplain. The sand units display landward thinning and disappear completely from the stratigraphy approximately 1 km inland from the coast, characteristic of tsunami deposits. All of the sand units have similar grain-size distribution, ranging from 70-120 ?m, which contrasts with the broader, bimodal distribution of grain size (10-450 ?m) from an eolian dune at the site and the coarser grain size (155-430 ?m) of the local beach sand. Intervening sediment layers consists of organic-rich silts and peat. AMS radiocarbon dates of Scirpus seeds found in peat directly below each sand layer indicate deposition of the sand layers has occurred within the past 800 years. The surficial sand layer (? 2 cm thick) is identified as the deposit from the 2010 tsunami. 137Cs measurements taken above, within, and below the second sand unit (4-7 cm) confirmed 14C results that this layer was deposited by the 1960 tsunami. Preliminary microfossil analysis indicates a slightly more marine diatom assemblage in the 1960 sand layer than in the organic-rich silt units above and below it, indicating a marine incursion. Lithology of the sand layers will further constrain their provenance. Comparison of the chronology of these deposits with the 500-year record of historical earthquakes in this region of Chile will be used to identify which tsunami events are preserved in the stratigraphy at Quidico. This information will help characterize the relative magnitude, preservation pattern, and history of past tsunamis within this transition zone. Correlating this record with additional geologic studies and historic accounts of earthquakes and tsunamis throughout the region will collectively advance our understanding of potential seismic hazards in south-central Chile.

  19. The influence of central neuropathic pain in paraplegic patients on performance of a motor imagery based Brain Computer Interface☆

    PubMed Central

    Vuckovic, A.; Hasan, M.A.; Osuagwu, B.; Fraser, M.; Allan, D.B.; Conway, B.A.; Nasseroleslami, B.

    2015-01-01

    Objective The aim of this study was to test how the presence of central neuropathic pain (CNP) influences the performance of a motor imagery based Brain Computer Interface (BCI). Methods In this electroencephalography (EEG) based study, we tested BCI classification accuracy and analysed event related desynchronisation (ERD) in 3 groups of volunteers during imagined movements of their arms and legs. The groups comprised of nine able-bodied people, ten paraplegic patients with CNP (lower abdomen and legs) and nine paraplegic patients without CNP. We tested two types of classifiers: a 3 channel bipolar montage and classifiers based on common spatial patterns (CSPs), with varying number of channels and CSPs. Results Paraplegic patients with CNP achieved higher classification accuracy and had stronger ERD than paraplegic patients with no pain for all classifier configurations. Highest 2-class classification accuracy was achieved for CSP classifier covering wider cortical area: 82 ± 7% for patients with CNP, 82 ± 4% for able-bodied and 78 ± 5% for patients with no pain. Conclusion Presence of CNP improves BCI classification accuracy due to stronger and more distinct ERD. Significance Results of the study show that CNP is an important confounding factor influencing the performance of motor imagery based BCI based on ERD. PMID:25698307

  20. Evidence-based evaluation of information: the centrality and limitations of systematic reviews.

    PubMed

    Jrvholm, Bengt; Bohlin, Ingemar

    2014-03-01

    This introductory paper considers the value and limitations of the methodology of systematic reviews especially according to the evidence-based movement. It explains some terms and organisations producing systematic reviews. It also discusses controversies. The first concerns the criteria by which the quality of individual studies is assessed, the second the possible effects of the affiliation of some reviewers, and the third the value of formalisation of procedure (i.e. the tensions between formal tools and professional judgments). The article contrasts the evidence-based formalism with other formalisms as those by the Intergovernmental Panel on Climate Change and the International Agency for Research on Cancer. It discusses systematic reviews in social science where interventions are complex, difficult to blind, and depend on context. Systematic reviews in working life research are often focusing on prevention. The formal evidence-based process may devaluate or disregard findings from mechanistic and observational studies. Hence such reviews may falsely conclude that existing knowledge about the risk of the factor is limited or nonexistent. PMID:24553849

  1. GIS-based seismic shaking slope vulnerability map of Sicily (Central Mediterranean)

    NASA Astrophysics Data System (ADS)

    Nigro, Fabrizio; Arisco, Giuseppe; Perricone, Marcella; Renda, Pietro; Favara, Rocco

    2010-05-01

    Earthquakes often represent very dangerouses natural events in terms of human life and economic losses and their damage effects are amplified by the synchronous occurrence of seismically-induced ground-shaking failures in wide regions around the seismogenic source. In fact, the shaking associated with big earthquakes triggers extensive landsliding, sometimes at distances of more than 100 km from the epicenter. The active tectonics and the geomorphic/morphodinamic pattern of the regions affected by earthquakes contribute to the slopes instability tendency. In fact, earthquake-induced groun-motion loading determines inertial forces activation within slopes that, combined with the intrinsic pre-existing static forces, reduces the slope stability towards its failure. Basically, under zero-shear stress reversals conditions, a catastrophic failure will take place if the earthquake-induced shear displacement exceeds the critical level of undrained shear strength to a value equal to the gravitational shear stress. However, seismic stability analyses carried out for various infinite slopes by using the existing Newmark-like methods reveal that estimated permanent displacements smaller than the critical value should also be regarded as dangerous for the post-earthquake slope safety, in terms of human activities use. Earthquake-induced (often high-speed) landslides are among the most destructive phenomena related to slopes failure during earthquakes. In fact, damage from earthquake-induced landslides (and other ground-failures), sometimes exceeds the buildings/infrastructures damage directly related to ground-shaking for fault breaking. For this matter, several hearthquakes-related slope failures methods have been developed, for the evaluation of the combined hazard types represented by seismically ground-motion landslides. The methodologies of analysis of the engineering seismic risk related to the slopes instability processes is often achieved through the evaluation of the permanent displacement potentially induced by an seismic scenario. Such methodologies found on the consideration that the conditions of seismic stability and the post-seismic functionality of engineering structures are tightly related to the entity of the permanent deformations that an earthquake can induce. Regarding the existing simplified procedures among slope stability models, Newmark's model is often used to derive indications about slope instabilities due to earthquakes. In this way, we have evaluated the seismically-induced landslides hazard in Sicily (Central Mediterranean) using the Newmark-like model. In order to determine the map distribution of the seismic ground-acceleration from an earthquake scenario, the attenuation-law of Sabetta & Pugliese has been used, analyzing some seismic recordings occurred in Italy. Also, by evaluating permanent displacements, the correlation of Ambraseys & Menu has been assumed. The seismic shaking slope vulnerability map of Sicily has been carried out using GIS application, also considering max seismic ground-acceleration peak distribution (in terms of exceedance probability for fixed time), slope acclivity, cohesion/angle of internal friction of outcropping rocks, allowing the zoning of the unstable slopes under seismic forces.

  2. Aetiologies of Central Nervous System Infection in Viet Nam: A Prospective Provincial Hospital-Based Descriptive Surveillance Study

    PubMed Central

    Ho Dang Trung, Nghia; Le Thi Phuong, Tu; Wolbers, Marcel; Nguyen Van Minh, Hoang; Nguyen Thanh, Vinh; Van, Minh Pham; Thieu, Nga Tran Vu; Le Van, Tan; Song, Diep To; Le Thi, Phuong; Thi Phuong, Thao Nguyen; Van, Cong Bui; Tang, Vu; Ngoc Anh, Tuan Hoang; Nguyen, Dong; Trung, Tien Phan; Thi Nam, Lien Nguyen; Kiem, Hao Tran; Thi Thanh, Tam Nguyen; Campbell, James; Caws, Maxine; Day, Jeremy; de Jong, Menno D.; Van Vinh, Chau Nguyen; Van Doorn, H. Rogier; Tinh, Hien Tran; Farrar, Jeremy; Schultsz, Constance

    2012-01-01

    Background Infectious diseases of the central nervous system (CNS) remain common and life-threatening, especially in developing countries. Knowledge of the aetiological agents responsible for these infections is essential to guide empiric therapy and develop a rational public health policy. To date most data has come from patients admitted to tertiary referral hospitals in Asia and there is limited aetiological data at the provincial hospital level where most patients are seen. Methods We conducted a prospective Provincial Hospital-based descriptive surveillance study in adults and children at thirteen hospitals in central and southern Viet Nam between August 2007 April 2010. The pathogens of CNS infection were confirmed in CSF and blood samples by using classical microbiology, molecular diagnostics and serology. Results We recruited 1241 patients with clinically suspected infection of the CNS. An aetiological agent was identified in 640/1241 (52%) of the patients. The most common pathogens were Streptococcus suis serotype 2 in patients older than 14 years of age (147/617, 24%) and Japanese encephalitis virus in patients less than 14 years old (142/624, 23%). Mycobacterium tuberculosis was confirmed in 34/617 (6%) adult patients and 11/624 (2%) paediatric patients. The acute case fatality rate (CFR) during hospital admission was 73/617 (12%) in adults and to 42/624 (7%) in children. Conclusions Zoonotic bacterial and viral pathogens are the most common causes of CNS infection in adults and children in Viet Nam. PMID:22662232

  3. Successful Implementation of a Unit-based Quality Nurse to Reduce Central Line-associated Bloodstream Infections

    PubMed Central

    Thom, Kerri A.; Li, Shanshan; Custer, Melissa; Preas, Michael Anne; Rew, Cindy D.; Cafeo, Christina; Leekha, Surbhi; Caffo, Brian S.; Scalea, Thomas M.; Lissauer, Matthew E.

    2013-01-01

    Background Central line-associated bloodstream infections (CLABSI) are an important cause of patient morbidity and mortality. Novel strategies to prevent CLABSI are needed. Methods We described a quasi-experimental study to examine the effect of the presence of a unit-based quality nurse (UQN), dedicated to perform patient safety and infection control activities with a focus on CLABSI reduction, on CLABSI rates in a surgical intensive care unit (SICU). Results From July 2008 to March 2012 there were 3257 SICU admissions; central line (CL) utilization ratio was 0.74 (18,193 CL days/24,576 patient days). The UQN program began in July 2010; the nurse was present for 30% (193/518) of the days of the intervention period of July 2010 to March 2012. The average CLABSI rate was 5.0 per 1000 CL days before the intervention and 1.5 after the intervention; and decreased by 5.1% (p = 0.005) for each additional 1% of days of the month that the UQN was present, even after adjusting for CLABSI rates in other adult ICUs, time, severity of illness, and On the CUSP participation (5.1%, p = 0.004). Approximately 11.4 CLABSIs were prevented. Conclusions The presence of a UQN dedicated to perform infection control activities may be an effective strategy for CLABSI reduction. PMID:24360354

  4. Configuring calendar variation based on time series regression method for forecasting of monthly currency inflow and outflow in Central Java

    NASA Astrophysics Data System (ADS)

    Setiawan, Suhartono, Ahmad, Imam Safawi; Rahmawati, Noorgam Ika

    2015-12-01

    Bank Indonesia (BI) as the central bank of Republic Indonesiahas a single overarching objective to establish and maintain rupiah stability. This objective could be achieved by monitoring traffic of inflow and outflow money currency. Inflow and outflow are related to stock and distribution of money currency around Indonesia territory. It will effect of economic activities. Economic activities of Indonesia,as one of Moslem country, absolutely related to Islamic Calendar (lunar calendar), that different with Gregorian calendar. This research aims to forecast the inflow and outflow money currency of Representative Office (RO) of BI Semarang Central Java region. The results of the analysis shows that the characteristics of inflow and outflow money currency influenced by the effects of the calendar variations, that is the day of Eid al-Fitr (moslem holyday) as well as seasonal patterns. In addition, the period of a certain week during Eid al-Fitr also affect the increase of inflow and outflow money currency. The best model based on the value of the smallestRoot Mean Square Error (RMSE) for inflow data is ARIMA model. While the best model for predicting the outflow data in RO of BI Semarang is ARIMAX model or Time Series Regression, because both of them have the same model. The results forecast in a period of 2015 shows an increase of inflow money currency happened in August, while the increase in outflow money currency happened in July.

  5. Healthcare information exchange system based on a hybrid central/federated model.

    PubMed

    Ghane, Kamran

    2014-01-01

    The quality of care can be significantly enhanced and healthcare cost can be substantially reduced if healthcare providers can have access to patient records that are scattered among several paper and electronic based systems. Major challenges of Healthcare Information Exchange result from patient's medical records being kept in several healthcare provider offices, clinics and hospitals in different formats. There are two major problems with healthcare information retrieval. The first problem is lack of visibility and knowledge as to where patient's medical records reside. The second problem is lack of access to information and also incompatibility of data formats. A considerable coverage of Electronic Information Exchange among Electronic Health Record (EHR) systems remains to be implemented despite extensive standardization efforts toward providing solutions. The adoption pace of available standards and solutions has been slow with the exception of some public/government entities. This paper describes a comprehensive and practical solution based on a distributed system with independent subsystems that control and manage processes and data flow of information exchange. The Registrar Subsystem creates a directory of healthcare providers and patients. The Security Subsystem provides authentication and authorization services across all subsystems. The Locators address patient and medical location lookup. The Agents act on behalf of healthcare providers to communicate with other subsystems. The Mediators facilitate information retrieval. The Solution comprises of three levels of participation that allows healthcare providers to join the system easily by starting from basic semi-manual information exchange level and then migrating to a fully electronic and automated information exchange. The Solution is modeled based on variety of standards and protocols used in Internet and other application fields as well as healthcare specific standards and proposals. PMID:25570220

  6. Geoid determination in Central Europe based on terrestrial data and GOCE observations

    NASA Astrophysics Data System (ADS)

    Rlke, A.; Liebsch, G.; Schfer, U.; Schirmer, U.; Ihde, J.

    2012-04-01

    The Federal Agency for Cartography and Geodesy (BKG) in Germany is in charge of the German quasigeoid as a reference surface for the German height system. A new quasigeoid GCG2011 for Germany was developed in collaboration with the colleagues from Institut fr Erdmessung (IfE), Hannover university. GCG2011 is based on an extensive database of terrestrial gravity data. The case-study presented here refers to the BKG gravity solution of GCG2011. This approach is based on a point mass representation in combination with remove-compute-restore-technique for the determination of the geoid. The dense spatial resolution of terrestrial observation data allows a reliable estimation of the short wavelengths of the gravity field. However, the longer wavelengths are more insecure. Here, recent gravity field missions, such as GOCE and GRACE, can help to improve the longer wavelength part. Our approach combines the benefits of the terrestrial and GOCE satellite observations in terms of accuracy and spatial resolution. The approach is introduced in detail and the results are discussed and evaluated.

  7. Object based change detection of Central Asian Tugai vegetation with very high spatial resolution satellite imagery

    NASA Astrophysics Data System (ADS)

    Gärtner, Philipp; Förster, Michael; Kurban, Alishir; Kleinschmit, Birgit

    2014-09-01

    Ecological restoration of degraded riparian Tugai forests in north-western China is a key driver to combat desertification in this region. Recent restoration efforts attempt to recover the forest along with its most dominant tree species, Populus euphratica. The present research observed the response of natural vegetation using an object based change detection method on QuickBird (2005) and WorldView2 (2011) data. We applied the region growing approach to derived Normalized Difference Vegetation Index (NDVI) values in order to identify single P. euphratica trees, delineate tree crown areas and quantify crown diameter changes. Results were compared to 59 reference trees. The findings confirmed a positive tree crown growth and suggest a crown diameter increase of 1.14 m, on average. On a single tree basis, tree crown diameters of larger crowns were generally underestimated. Small crowns were slightly underestimated in QuickBird and overestimated in Worldview2 images. The results of the automated tree crown delineation show a moderate relation to field reference data with R20052: 0.36 and R20112: 0.48. The object based image analysis (OBIA) method proved to be applicable in sparse riparian Tugai forests and showed great suitability to evaluate ecological restoration efforts in an endangered ecosystem.

  8. Wetlands Maps of Central Canada based on L-band SAR Imagery

    NASA Astrophysics Data System (ADS)

    Whitcomb, J.; Moghaddam, M.; Clewley, D.; McDonald, K. C.; Podest, E.; Chapman, B. D.

    2013-12-01

    Many boreal wetlands appear to be evolving into significant sources of greenhouse gases. The ability to accurately quantify the locations, types, and extents of northern wetlands is important to understanding their role in the global carbon cycle and responses to changes in climate. However, due to the extent of boreal wetlands and their inaccessibility, there have been few maps produced of this important ecosystem. To address this need, we have been constructing high-resolution (100 m) thematic maps of North American boreal wetlands. The maps are developed using space-based synthetic aperture radar (SAR), which is capable of efficiently providing high-resolution imagery of vast and often inaccessible regions. Unlike optical imagery, space-based SAR imagery is unaffected by cloud cover. Additionally, L-band SAR is able to sense vegetation structure and moisture content, as well as ground and surface water characteristics (even under vegetation canopies), thereby providing information unobtainable from optical sensors. Space-based L-band SAR thus constitutes an excellent tool for mapping boreal wetlands. One wetlands map is based on HH-polarized L-band SAR imagery from the Japanese Earth Resources Satellite (JERS-1), collected for both summer and winter in the late 1990s. A second map is based on dual-polarized (HH and HV) imagery from the Phased Array L-band SAR (PALSAR) sensor, collected in the summer of 2007. Prior to classification, a sequence of preprocessing steps are executed, including filtering, mosaicking, resampling, reprojection, co-registration, and the formation of supplementary data layers such as image texture, topographic slope, and proximity to water. This preprocessing is implemented by a semi-automated software suite specifically designed to handle the large volumes of data involved in the project. Training/testing data needed in the classification process are formed by merging national wetland inventory and land cover databases. Finally, a 'Random Forests' decision tree classifier takes in the processed SAR and other data layers, along with the training/testing data, and uses them to produce a thematic wetlands map. The accuracy of the resulting classification product is quantified by calculating producer and user error statistics for all validation pixels within the mapped region. Thematic change maps are generated from the SAR-derived maps, thereby allowing decadal changes in wetland extent and type to be identified. These change maps provide information on wetland dynamics and responses to anthropogenic and climatic influences over a large spatial area. This work was done in part within the ALOS Kyoto & Carbon Initiative, with portions carried out at the University of Southern California and at the Jet Propulsion Laboratory under contract to National Aeronautics and Space Administration. PALSAR data were provided by JAXA/EORC and the Alaska Satellite Facility.

  9. Central odontogenic fibroma of the maxilla

    PubMed Central

    El Harti, Karima; Oujilal, Abdelilah; El Wady, Wafaa

    2015-01-01

    Central odontogenic fibroma (COF) is an uncommon tumor that accounts for 0.1% of all odontogenic tumors; it has been defined as a benign neoplasm of the jaw. Clinically, the lesion grows slowly and leads to cortical expansion. Radiologically, the most common finding is multilocular radiolucency. The lesions are associated with the crown of an unerupted molar, premolar, or incisor tooth and in some cases, with root resorption or displacement. Histologically, the lesion is characterized by mature collagen fibers and numerous fibroblasts. COF responds well to surgical enucleation with no tendency for malignancy or recurrence. We report a case of a 15-year-old female patient presented with painless swelling of the left side of the maxilla since her childhood. Radiographs revealed an expanding ill-defined radiolucency with a displacement of the adjacent tooth. The impacted tooth was pushed posteriorly. The lesion was removed surgically. There were no postoperative complications. PMID:26752885

  10. Improving depth imaging of legacy seismic data using curvelet-based gather conditioning: A case study from Central Poland

    NASA Astrophysics Data System (ADS)

    Grszczyk, A.; Cyz, M.; Malinowski, M.

    2015-06-01

    In presented work we test the ray-based pre-stack depth migration (PreSDM) and tomographic velocity model building (VMB) workflow applied to vintage seismic data, acquired in the 70s and 80s, in the area affected by intense salt tectonics in Central Poland. We demonstrate that the key for successful VMB is the consistency of the input residual moveouts (RMO) picks, which we obtain by developing proper gather conditioning workflow. It is based on the 2D discrete curvelet transform (DCT). DCT-based conditioning algorithm is run in a two-step mode on the common offset sections and on the depth-slices, improving the performance of the autopicker and thus providing a more reliable input to a grid tomography. Additionally, in the case of the legacy data, such conditioning acts as a trace regularization. Taking into account limitations associated with low fold and low signal-to-noise ratio, obtained results are satisfactory, providing depth sections and velocity models for verifying structural interpretation of the study area. In the case when the grid-based tomography is applied to vintage data, we strongly recommend to devote some time for proper data conditioning aimed at signal coherency improvement before running the RMO autopicker.

  11. A conodont-based standard reference section in central Nevada for the lower Middle Ordovician Whiterockian Series

    USGS Publications Warehouse

    Sweet, W.C.; Ethington, Raymond L.; Harris, A.G.

    2005-01-01

    Ranges of conodonts in stratigraphic sections at five localities in the Monitor and Antelope ranges of central Nevada are used graphically to assemble a standard reference section for the lower Middle Ordovician Whiterockian Series. The base of the series is officially 0.3 m above the base of the Antelope Valley Limestone in the stratotype in Whiterock Canyon (Monitor Range). The top is the level at which Baltoniodus gerdae makes a brief appearance in an exposure of the Copenhagen Formation on the flanks of Hill 8308 in the western Antelope Range. Graphic compilation of the sections considered in this report also indicates that a level correlative with the base of the Whiterockian Series in the stratotype section is 66 m above the base of the Antelope Valley Limestone in its de facto type section on Martin Ridge in the eastern part of the Monitor Range. Ranges, diversity, and the composition of the conodont faunas differ markedly in lithofacies adjacent to the basal boundary of the series; hence we are unable to identify a single conodont species, in a credible developmental sequence, to serve as biological marker of that boundary.

  12. Simulation of a rubber plantation productivity in central Cambodia using the individual-based dynamic vegetation model SEIB-DGVM

    NASA Astrophysics Data System (ADS)

    Kumagai, T.; SATO, H.; Shinjiro, Ph. D., F.

    2013-12-01

    To provide a useful tool for building strategy of forest plantation management, we developed the Spatially Explicit Individual-Based (SEIB) Dynamic Global Vegetation Model (DGVM) applicable to simulate productivity of tree plantations (SEIB-PP). Rubber (Hevea brasiliensis Mll. Arg.) plantations, which are rapidly expanding into both climatically optimal and sub-optimal environments throughout mainland Southeast Asia, potentially change the partitioning of water, energy, and carbon at multiple scales, compared with traditional land covers that are being replaced. Describing both primary and latex productivities in rubber plantations via SEIB-PP is, therefore, important to understanding the climatic impacts on productive processes. Model results are compared with measurements collected at a field site in central Cambodia, and here, we show some examples of projections: the rubber plantation production under future climate change conditions.

  13. Centrally controlled self-healing wavelength division multiplexing passive optical network based on optical carrier suppression technique

    NASA Astrophysics Data System (ADS)

    Zhu, Min; Zhang, Jiao; Sun, Xiaohan

    2015-12-01

    We proposed and demonstrated a centrally controlled and self-healing wavelength division multiplexing passive optical network with colorless optical network units (ONUs) based on optical carrier suppression technique. By switching the affected data in the OCS signal sideband to an alternate protection path, only one optical switch is provisioned at the optical line terminal, which is controlled by a logic control circuit upon monitoring of power outage on the working path. The proposed scheme can reliably protect against both distribution and feeder fiber failures. Moreover, gain-saturated reflective semiconductor optical amplifiers are used as colorless transmitters in ONUs. The protection scheme feasibility and system performances are experimentally verified with 10 Gb/s downstream and 1.25 Gb/s upstream data in both working and protection modes. The protection switching time was measured to be around 1 ms.

  14. A new species of Centropages (Copepoda: Calanoida: Centropagidae) from the central Red Sea based on morphological and molecular evidence.

    PubMed

    El-Sherbiny, Mohsen M; Al-Aidaroos, Ali M

    2015-01-01

    Centropages mohamedi sp. nov. (Copepoda: Calanoida) is described from specimens collected in zooplankton samples off Obhur Creek on the Saudi Arabian coast of the central Red Sea. The new species is most closely related to C. orsinii Giesbrecht, 1889, a species described from the Red Sea and widely distributed in the neritic waters of the Indo-West Pacific region. The new species is mainly distinguished by the female genital double somite, male antennules, male leg 4, and leg 5 of both sexes. DNA sequences of the mitochondrial cytochrome C oxidase subunit one (mtCOI) of the two species differ by 20.8%, supporting their morphology-based identification as distinct species.  PMID:25661620

  15. Effect of central mode on the dielectric tunability of ferroelectrics near room temperature: a first-principle-based study.

    PubMed

    Weerasinghe, Jeevaka; Wang, Dawei; Bellaiche, L

    2013-06-26

    First-principles-based effective Hamiltonian molecular dynamics simulations are performed to investigate GHz-THz dynamical properties of bulk and epitaxially strained film made of SrTiO3 near room temperature. Our simulations confirm the huge dielectric tunability recently observed in films. Moreover, universal phenomenological laws, with bulk-like parameters, are found to describe reasonably well the dielectric tunability-versus-dc electric field curves in both systems at low and high electric fields, except for the sole case of the STO film in the low-field regime. Such deviation originates from the presence of a central mode in this low-dimensional system. A revised equation, arising from an original analysis of the simulations, is proposed for modeling this latter situation. PMID:23719129

  16. A high-order vertex-based central ENO finite-volume scheme for three-dimensional compressible flows

    DOE PAGESBeta

    Charest, Marc R.J.; Canfield, Thomas R.; Morgan, Nathaniel R.; Waltz, Jacob; Wohlbier, John G.

    2015-03-11

    High-order discretization methods offer the potential to reduce the computational cost associated with modeling compressible flows. However, it is difficult to obtain accurate high-order discretizations of conservation laws that do not produce spurious oscillations near discontinuities, especially on multi-dimensional unstructured meshes. A novel, high-order, central essentially non-oscillatory (CENO) finite-volume method that does not have these difficulties is proposed for tetrahedral meshes. The proposed unstructured method is vertex-based, which differs from existing cell-based CENO formulations, and uses a hybrid reconstruction procedure that switches between two different solution representations. It applies a high-order k-exact reconstruction in smooth regions and a limited linearmore » reconstruction when discontinuities are encountered. Both reconstructions use a single, central stencil for all variables, making the application of CENO to arbitrary unstructured meshes relatively straightforward. The new approach was applied to the conservation equations governing compressible flows and assessed in terms of accuracy and computational cost. For all problems considered, which included various function reconstructions and idealized flows, CENO demonstrated excellent reliability and robustness. Up to fifth-order accuracy was achieved in smooth regions and essentially non-oscillatory solutions were obtained near discontinuities. The high-order schemes were also more computationally efficient for high-accuracy solutions, i.e., they took less wall time than the lower-order schemes to achieve a desired level of error. In one particular case, it took a factor of 24 less wall-time to obtain a given level of error with the fourth-order CENO scheme than to obtain the same error with the second-order scheme.« less

  17. A high-order vertex-based central ENO finite-volume scheme for three-dimensional compressible flows

    SciTech Connect

    Charest, Marc R.J.; Canfield, Thomas R.; Morgan, Nathaniel R.; Waltz, Jacob; Wohlbier, John G.

    2015-03-11

    High-order discretization methods offer the potential to reduce the computational cost associated with modeling compressible flows. However, it is difficult to obtain accurate high-order discretizations of conservation laws that do not produce spurious oscillations near discontinuities, especially on multi-dimensional unstructured meshes. A novel, high-order, central essentially non-oscillatory (CENO) finite-volume method that does not have these difficulties is proposed for tetrahedral meshes. The proposed unstructured method is vertex-based, which differs from existing cell-based CENO formulations, and uses a hybrid reconstruction procedure that switches between two different solution representations. It applies a high-order k-exact reconstruction in smooth regions and a limited linear reconstruction when discontinuities are encountered. Both reconstructions use a single, central stencil for all variables, making the application of CENO to arbitrary unstructured meshes relatively straightforward. The new approach was applied to the conservation equations governing compressible flows and assessed in terms of accuracy and computational cost. For all problems considered, which included various function reconstructions and idealized flows, CENO demonstrated excellent reliability and robustness. Up to fifth-order accuracy was achieved in smooth regions and essentially non-oscillatory solutions were obtained near discontinuities. The high-order schemes were also more computationally efficient for high-accuracy solutions, i.e., they took less wall time than the lower-order schemes to achieve a desired level of error. In one particular case, it took a factor of 24 less wall-time to obtain a given level of error with the fourth-order CENO scheme than to obtain the same error with the second-order scheme.

  18. Are Physiologically Based Pharmacokinetic Models Reporting the Right C(max)? Central Venous Versus Peripheral Sampling Site.

    PubMed

    Musther, Helen; Gill, Katherine L; Chetty, Manoranjenni; Rostami-Hodjegan, Amin; Rowland, Malcolm; Jamei, Masoud

    2015-09-01

    Physiologically based pharmacokinetic (PBPK) models can over-predict maximum plasma concentrations (C(max)) following intravenous administration. A proposed explanation is that invariably PBPK models report the concentration in the central venous compartment, rather than the site where the samples are drawn. The purpose of this study was to identify and validate potential corrective models based on anatomy and physiology governing the blood supply at the site of sampling and incorporate them into a PBPK platform. Four models were developed and scrutinised for their corrective potential. All assumed the peripheral sampling site concentration could be described by contributions from surrounding tissues and utilised tissue-specific concentration-time profiles reported from the full-PBPK model within the Simcyp Simulator. Predicted concentrations for the peripheral site were compared to the observed C(max). The models results were compared to clinical data for 15 studies over seven compounds (alprazolam, imipramine, metoprolol, midazolam, omeprazole, rosiglitazone and theophylline). The final model utilised tissue concentrations from adipose, skin, muscle and a contribution from artery. Predicted C(max) values considering the central venous compartment can over-predict the observed values up to 10-fold whereas the new sampling site predictions were within 2-fold of observed values. The model was particularly relevant for studies where traditional PBPK models over-predict early time point concentrations. A successful corrective model for C(max) prediction has been developed, subject to further validation. These models can be enrolled as built-up modules into PBPK platforms and potentially account for factors that may affect the initial mixing of the blood at the site of sampling. PMID:26100012

  19. Energy-based Location and Wavefield Polarization Analysis of Tectonic Tremors in Central Mexico

    NASA Astrophysics Data System (ADS)

    Cruz-Atienza, V. M.; Husker, A. L.; Legrand, D.; Kostoglodov, V.

    2013-05-01

    We have designed a location technique based on non-volcanic tremor (NVT) energy measurements and their spatial derivatives in the three ground motion components. By means of a source-scanning grid search and a large database of theoretical Green's functions (i.e. more than 45,000 functions from rake-variable horizontal point dislocations) accounting for both intrinsic attenuation and layered media, the algorithm looks for the hypocentral locations that minimize an error function between observed and synthetic spatial-energy distributions. However, since the energy has little information about the footprint of the source-radiation-pattern on the wavefield polarization we have introduced, into the location algorithm, a particle-motion polarization analysis. The analysis is based on the eigendecomposition of the covariance matrix determined from the three ground motion components, and provides the algorithm with much better control of both NVT location and source mechanism (i.e. dislocation rake angle). Preliminary locations of the NVT catalogue by Husker et al. (2010) for the Guerrero province confirmed the coastward spreading of the NVT activity during the 2006 Slow Slip Event, recently reported. Although the horizontal NVT-energy distribution changes along the one-dimensional MASE array from downdip to updip locations, our results show that this variation may be explained, for all NVT's, with approximately the same rake angle, which differs from the plate convergence direction by 15 to 20 degrees clockwise. Moreover, although a few NVT foci are located within the deep continental crust (i.e. between 30 and 40 km depth), most of the NVT activity is embedded within the subducted slab, below the 40 km depth Moho. Most of the intraslab activity lies between 200 and 240 km from the trench (region called the 'Sweet Spot' by Husker et al., 2012) with 40 to 50 km depth. By superimposing the NVT hypocentral cross-section locations over the state of pore pressure (Pp) computationally modeled within the slab due to the strain field induced by previous Slow Slip Events in the region (Cruz-Atienza et al., 2011), a surprisingly good spatial correlation appears between a low pore-pressure slab segment toward which fluids diffuse and the 'Sweet Spot', where most of the NVT bursts are systematically located.

  20. Wetland Maps of Central Canada based on L-band SAR Imagery

    NASA Astrophysics Data System (ADS)

    Whitcomb, J.; Clewley, D.; Moghaddam, M.; McDonald, K. C.

    2014-12-01

    Northern wetlands have the potential to become major sources of greenhouse gases. Detailed and accurate maps of the locations, types, and extents of these wetlands are therefore essential to the development of accurate carbon budgets. However, due to their vast extent and inaccessibility, most northern wetlands remain unmapped. We have been constructing high-resolution (100 m) thematic maps of boreal wetlands, with current focus on Canadian wetlands. The maps are developed using spaceborne synthetic aperture radar (SAR), which efficiently collects high-resolution imagery over extensive regions and, unlike optical sensors, is unimpaired by clouds or lack of sunlight. Spaceborne L-band (~1.3 GHz) SAR, in particular, records scene characteristics imperceptible to optical sensors such as vegetation structure and moisture content, soil moisture and roughness, and canopy-obscured surface waters. These attributes make it the best single tool for mapping boreal wetlands. Two L-band SAR-based wetland maps are being assembled: one using HH-polarized imagery from the JERS-1 satellite collected in the winter and summer of 1997-1998, and a second using dual-polarized (HH and HV) imagery from the PALSAR sensor of the ALOS satellite collected in the summer of 2008. Ancillary data layers such as image texture, topographic slope, and proximity to water are also generated, and a training/testing data layer is formed by merging polygons from the Canadian Wetland Inventory (CWI) with other land cover databases. A Random Forests decision tree classifier takes as input the SAR, ancillary, and training/testing data layers and uses them to produce thematic wetland maps. The accuracy of each map is quantified via producer and user error statistics. Finally, the SAR-based wetland maps are compared to form a 1998-2008 wetlands change map. Recent advances include a powerful new software suite developed to handle huge volumes of data and much-improved JERS-1 registration. Challenges, including non-GIS-ready CWI data and nonstructural CWI class definitions, are being addressed. This work was carried out in part within the ALOS Kyoto & Carbon Initiative at the University of Southern California and Jet Propulsion Laboratory (JPL) under contract to NASA. JERS-1 mosaics were generated by JPL. PALSAR mosaics were provided by JAXA/EORC.

  1. Stem and progenitor cell-based therapy of the human central nervous system.

    PubMed

    Goldman, Steve

    2005-07-01

    Multipotent neural stem cells, capable of giving rise to both neurons and glia, line the cerebral ventricles of all adult animals, including humans. In addition, distinct populations of nominally glial progenitor cells, which also have the capacity to generate several cell types, are dispersed throughout the subcortical white matter and cortex. A number of approaches have evolved for using neural progenitor cells in cell therapy. Four strategies are especially attractive for clinical translation: first, transplantation of oligodendrocyte progenitor cells as a means of treating the disorders of myelin; second, transplantation of phenotypically restricted neuronal progenitor cells to treat diseases of discrete loss of a single neuronal phenotype, such as Parkinson disease; third, implantation of mixed progenitor pools to treat diseases characterized by the loss of several discrete phenotypes, such as spinal cord injury; and fourth, mobilization of endogenous neural progenitor cells to restore neurons lost as a result of neurodegenerative diseases, in particular Huntington disease. Together, these may present the most compelling strategies and near-term disease targets for cell-based neurological therapy. PMID:16003375

  2. Beyond the Central Dogma: Model-Based Learning of How Genes Determine Phenotypes

    PubMed Central

    Reinagel, Adam; Bray Speth, Elena

    2016-01-01

    In an introductory biology course, we implemented a learner-centered, model-based pedagogy that frequently engaged students in building conceptual models to explain how genes determine phenotypes. Model-building tasks were incorporated within case studies and aimed at eliciting students’ understanding of 1) the origin of variation in a population and 2) how genes/alleles determine phenotypes. Guided by theory on hierarchical development of systems-thinking skills, we scaffolded instruction and assessment so that students would first focus on articulating isolated relationships between pairs of molecular genetics structures and then integrate these relationships into an explanatory network. We analyzed models students generated on two exams to assess whether students’ learning of molecular genetics progressed along the theoretical hierarchical sequence of systems-thinking skills acquisition. With repeated practice, peer discussion, and instructor feedback over the course of the semester, students’ models became more accurate, better contextualized, and more meaningful. At the end of the semester, however, more than 25% of students still struggled to describe phenotype as an output of protein function. We therefore recommend that 1) practices like modeling, which require connecting genes to phenotypes; and 2) well-developed case studies highlighting proteins and their functions, take center stage in molecular genetics instruction. PMID:26903496

  3. A probe-density-based analysis method for array CGH data: simulation, normalization and centralization

    PubMed Central

    Chen, Hung-I Harry; Hsu, Fang-Han; Jiang, Yuan; Tsai, Mong-Hsun; Yang, Pan-Chyr; Meltzer, Paul S.; Chuang, Eric Y.; Chen, Yidong

    2008-01-01

    Motivation: Genomic instability is one of the fundamental factors in tumorigenesis and tumor progression. Many studies have shown that copy-number abnormalities at the DNA level are important in the pathogenesis of cancer. Array comparative genomic hybridization (aCGH), developed based on expression microarray technology, can reveal the chromosomal aberrations in segmental copies at a high resolution. However, due to the nature of aCGH, many standard expression data processing tools, such as data normalization, often fail to yield satisfactory results. Results: We demonstrated a novel aCGH normalization algorithm, which provides an accurate aCGH data normalization by utilizing the dependency of neighboring probe measurements in aCGH experiments. To facilitate the study, we have developed a hidden Markov model (HMM) to simulate a series of aCGH experiments with random DNA copy number alterations that are used to validate the performance of our normalization. In addition, we applied the proposed normalization algorithm to an aCGH study of lung cancer cell lines. By using the proposed algorithm, data quality and the reliability of experimental results are significantly improved, and the distinct patterns of DNA copy number alternations are observed among those lung cancer cell lines. Contact: chuangey@ntu.edu.tw Supplementary information: Source codes and.gures may be found at http://ntumaps.cgm.ntu.edu.tw/aCGH_supplementary PMID:18603568

  4. Treatment of a molasses based distillery effluent in a constructed wetland in central India.

    PubMed

    Billore, S K; Singh, N; Ram, H K; Sharma, J K; Singh, V P; Nelson, R M; Dass, P

    2001-01-01

    A field-scale 4-celled, horizontal subsurface constructed wetland (CW) was installed to evaluate removal efficiencies of wastewater constituents in an industrial distillery effluent. Total and dissolved solids, NH4-N, TKN, P and COD were measured. This CW design provides four serial cells with synthetic liners and a river gravel base. The first two unplanted cells provide preliminary treatment. Specific gravel depths and ensuing biofilm growth provides anaerobic treatment in Cell 1 and anaerobic treatment in Cell 2. Cell 3 was planted with Typha latifolia with an inserted layer of brick rubble (for phosphorus removal). Locally grown reed, Phragmites karka was planted in Cell 4. COD was reduced from 8420 mg/l 3000 from Cell 1 to the outlet of Cell 4. Likewise other parameters: total and dissolved solids, ammonium and total nitrogen, and total P, indicated declining trends at the 4-celled CW effluent. This study reveals how high strength distillery wastewater strongly impacts morphology, aeration anatomy in the chiseled plant tissues, reed growth; and composition of the biofilm in the specialized substratum. The reliability of a CW for organic and nutrients reduction, in association with a poorly performing conventional system is discussed. There is an immense potential for appropriately designed constructed wetlands to improve high strength wastewaters in India. PMID:11804132

  5. Beyond the Central Dogma: Model-Based Learning of How Genes Determine Phenotypes.

    PubMed

    Reinagel, Adam; Bray Speth, Elena

    2016-01-01

    In an introductory biology course, we implemented a learner-centered, model-based pedagogy that frequently engaged students in building conceptual models to explain how genes determine phenotypes. Model-building tasks were incorporated within case studies and aimed at eliciting students' understanding of 1) the origin of variation in a population and 2) how genes/alleles determine phenotypes. Guided by theory on hierarchical development of systems-thinking skills, we scaffolded instruction and assessment so that students would first focus on articulating isolated relationships between pairs of molecular genetics structures and then integrate these relationships into an explanatory network. We analyzed models students generated on two exams to assess whether students' learning of molecular genetics progressed along the theoretical hierarchical sequence of systems-thinking skills acquisition. With repeated practice, peer discussion, and instructor feedback over the course of the semester, students' models became more accurate, better contextualized, and more meaningful. At the end of the semester, however, more than 25% of students still struggled to describe phenotype as an output of protein function. We therefore recommend that 1) practices like modeling, which require connecting genes to phenotypes; and 2) well-developed case studies highlighting proteins and their functions, take center stage in molecular genetics instruction. PMID:26903496

  6. Association between Dental Erosion and Diet in Brazilian Adolescents Aged from 15 to 19: A Population-Based Study

    PubMed Central

    Aguiar, Yêska Paola Costa; dos Santos, Fábio Gomes; Moura, Eline Freitas de Farias; da Costa, Fernanda Clotilde Mariz; Auad, Sheyla Marcia; de Paiva, Saul Martins; Cavalcanti, Alessandro Leite

    2014-01-01

    Dental erosion is a pathological condition resulting from the irreversible dissolution of the mineralized portion of the teeth, being recognized in modern society as an important cause of loss of tooth structure. The aim of this study was to assess the prevalence and its association with diet in Brazilian adolescents of Campina Grande, PB, Brazil. A population-based study was conducted on a stratified sample of 675 adolescents aged from 15 to 19 of both sexes using the index proposed by O'Sullivan. Dental examinations were performed by two calibrated dentists (kappa = 0.82). The significance level adopted was 5%. The prevalence of dental erosion was 21%, and the upper central incisors and lateral incisors were the most affected elements, with 50.5% and 40.2%, respectively. The buccal surface showed greater impairment (51.4%) and 67.8% of teeth with dental erosion had more than half of the surface of affected area. Most damage was on the enamel (93.5%). There were no statistically significant differences between the occurrence of dental erosion and gender, age, socioeconomic status, self-reported ethnicity, and diet. There was high prevalence of dental erosion in its early stages among adolescents and there were no significant differences in the frequency of the consumption of foods and beverages and the presence of dental erosion. PMID:24695943

  7. Using trait-based approaches to study phytoplankton seasonal succession in a subtropical reservoir in arid central western Argentina.

    PubMed

    Beamud, S G; Len, J G; Kruk, C; Pedrozo, F; Diaz, M

    2015-05-01

    The application of trait-based approaches has become a widely applied tool to analyse community assembly processes and dynamics in phytoplankton communities. Its advantages include summarizing information of many species without losing essentials of the main driving processes. Here, we used trait-based approaches to study phytoplankton temporal succession in a subtropical reservoir. We applied a combined approach including morphological traits (i.e. volume, surface) and functional clustering of species (morphology-based functional groups (MBFG) and Reynolds' groups) and related the clustering of species with the environment. We found that this reservoir is characterized by a low richness and a bimodal distribution of phytoplankton biomass. Taxonomic and functional classifications were coincident, and the dominant species and groups biomasses were explained by the same group of variables. For instance, group X?, MBFG V and Carteria sp. biomasses were explained by: pH, Secchi disk depth, N-NH?; while group B, MBFG VI and Cyclotella ocellata biomasses were explained by stability of the water column, incident solar radiation, Secchi disk depth and N-NH4. From our results, we state that functional and taxonomic classifications are complementary rather than opposed approaches, and their specific uses depend exclusively on the aim of the study and the characteristics of the environment under evaluation. Our work is the first description of phytoplankton dynamics in a reservoir in the arid central western Argentina (Cuyo region). PMID:25893768

  8. A Role for Fragment-Based Drug Design in Developing Novel Lead Compounds for Central Nervous System Targets

    PubMed Central

    Wasko, Michael J.; Pellegrene, Kendy A.; Madura, Jeffry D.; Surratt, Christopher K.

    2015-01-01

    Hundreds of millions of U.S. dollars are invested in the research and development of a single drug. Lead compound development is an area ripe for new design strategies. Therapeutic lead candidates have been traditionally found using high-throughput in vitro pharmacological screening, a costly method for assaying thousands of compounds. This approach has recently been augmented by virtual screening (VS), which employs computer models of the target protein to narrow the search for possible leads. A variant of VS is fragment-based drug design (FBDD), an emerging in silico lead discovery method that introduces low-molecular weight fragments, rather than intact compounds, into the binding pocket of the receptor model. These fragments serve as starting points for “growing” the lead candidate. Current efforts in virtual FBDD within central nervous system (CNS) targets are reviewed, as is a recent rule-based optimization strategy in which new molecules are generated within a 3D receptor-binding pocket using the fragment as a scaffold. This process not only places special emphasis on creating synthesizable molecules but also exposes computational questions worth addressing. Fragment-based methods provide a viable, relatively low-cost alternative for therapeutic lead discovery and optimization that can be applied to CNS targets to augment current design strategies. PMID:26441817

  9. A 2000 year varve-based climate record from the central Brooks Range, Alaska

    SciTech Connect

    Bird, BW; Abbott, MB; Finney, BP; Kutchko, B

    2009-01-01

    Varved minerogenic sediments from glacial-fed Blue Lake, northern Alaska, are used to investigate late Holocene climate variability. Varve-thickness measurements track summer temperature recorded at Atigun Pass, located 41 km east at a similar elevation (r (2) = 0.31, P = 0.08). Results indicate that climate in the Brooks Range from 10 to 730 AD (varve year) was warm with precipitation inferred to be higher than during the twentieth century. The varvetemperature relationship for this period was likely compromised and not used in our temperature reconstruction because the glacier was greatly reduced, or absent, exposing sub-glacial sediments to erosion from enhanced precipitation. Varve-inferred summer temperatures and precipitation decreased after 730 AD, averaging 0.4A degrees C above the last millennial average (LMA = 4.2A degrees C) from 730 to 850 AD, and 0.1A degrees C above the LMA from 850 to 980 AD. Cooling culminated between 980 and 1030 AD with temperatures 0.7A degrees C below the LMA. Varve-inferred summer temperatures increased between 1030 and 1620 AD to the LMA, though the period between 1260 and 1350 AD was 0.2A degrees C below the LMA. Although there is no equivalent to the European Medieval Warm Period in the Blue Lake record, two warm intervals occurred from 1350 to 1450 AD and 1500 to 1620 AD (0.4 and 0.3A degrees C above the LMA, respectively). During the Little Ice Age (LIA; 1620 to 1880 AD), inferred summer temperature averaged 0.2A degrees C below the LMA. After 1880 AD, inferred summer temperature increased to 0.8A degrees C above the LMA, glaciers retreated, but aridity persisted based on a number of regional paleoclimate records. Despite warming and glacial retreat, varve thicknesses have not achieved pre-730 AD levels. This reflects limited sediment availability and transport due to a less extensive retreat compared to the first millennium, and continued relative aridity. Overall, the Blue Lake record is similar to varve records from the eastern Canadian Arctic that document a cool LIA and twentieth century warming. However, the occurrence and timing of events, such as the LIA and Medieval Warm Period, varies considerably among records, suggesting heterogeneous climatic patterns across the North American Arctic.

  10. Two takes on the ecosystem impacts of climate change and fishing: Comparing a size-based and a species-based ecosystem model in the central North Pacific

    NASA Astrophysics Data System (ADS)

    Woodworth-Jefcoats, Phoebe A.; Polovina, Jeffrey J.; Howell, Evan A.; Blanchard, Julia L.

    2015-11-01

    We compare two ecosystem model projections of 21st century climate change and fishing impacts in the central North Pacific. Both a species-based and a size-based ecosystem modeling approach are examined. While both models project a decline in biomass across all sizes in response to climate change and a decline in large fish biomass in response to increased fishing mortality, the models vary significantly in their handling of climate and fishing scenarios. For example, based on the same climate forcing the species-based model projects a 15% decline in catch by the end of the century while the size-based model projects a 30% decline. Disparities in the models' output highlight the limitations of each approach by showing the influence model structure can have on model output. The aspects of bottom-up change to which each model is most sensitive appear linked to model structure, as does the propagation of interannual variability through the food web and the relative impact of combined top-down and bottom-up change. Incorporating integrated size- and species-based ecosystem modeling approaches into future ensemble studies may help separate the influence of model structure from robust projections of ecosystem change.

  11. Treatment of Dens Invagination in a Maxillary Lateral Incisor: A Case Report

    PubMed Central

    Heydari, Azar; Rahmani, Mona

    2015-01-01

    Dens invagination is a developmental anomaly requiring specific treatment approaches. Oehler's Type III dens in dente, extends into the root and perforates at the apical area or lateral surface of the root. In this case endodontic treatment of the invaginated tooth was carried out through the central lumen of the invagination with calcium hydroxide without manipulation of the main pulp canal, thereby leaving the tooth vital. The 18-month follow-up examinations were indicative of treatment success; the periapical lesion resolved completely and the tooth remained vital. Conclusion: Information about the three dimensional anatomy of the teeth especially those with an abnormality is necessary for a successful treatment. PMID:26213545

  12. Effects of guanine bases at the central loop on stabilization of the quadruplex DNAs and their interactions with Meso-tetrakis(N-methylpyridium-4-yl)porphyrin.

    PubMed

    Jeon, Sun Hee; Moon, Jihye; Lee, Myung Won; Kim, Seog K

    2015-10-01

    The thermal stability of the G-quadruplex formed from the thrombin-binding aptamer, 5'G2T2G2TGTG2T2G2, in which the guanine (G) base at the central loop was replaced with an adenine (A) or inosine (I) base, was examined to determine the role of the central G base in stabilizing the quadruplex. Replacement of the central G base by the I base resulted in a slight decrease in thermal stability. On the other hand, the stability of the G-quadruplex decreased to a significant extent when it was replaced with the A base. The optimized structure of the G-quadruplex, which was obtained by a molecular dynamic simulation, showed that the carbonyl group of the C5 position of the central G base could form hydrogen bonds with the G1 amine group at the C7 position on the upper G-quartet. This formation of a hydrogen bond contributes to the stability of the G-quadruplex. The spectral property of meso-tetrakis(N-methylpyridium-4yl)porphyrin (TMPyP) associated with the G-quadruplex was characterized by a moderate red shift and hypochromism in the absorption spectrum, a positive CD signal, and two emission maxima in the fluorescence emission spectrum, suggesting that TMPyP binds at the exterior of the G-quadruplex. Spectral properties were slightly altered when the G base at the central loop was replaced with A or I, while the fluorescence decay times of TMPyP associated with the G-quadruplex were identical. Observed spectral properties removes the possibility of intercalation binding mode for TMPyP. TMPyP binds at the exterior of the quadruplex. Whether it stacks on the central loop or binds at the side of the quadruplex is unclear at this stage. PMID:26057195

  13. Structural interpretation and physical property estimates based on COAST 2012 seismic reflection profiles offshore central Washington, Cascadia subduction zone

    NASA Astrophysics Data System (ADS)

    Webb, S. I.; Tobin, H. J.; Everson, E. D.; Fortin, W.; Holbrook, W. S.; Kent, G.; Keranen, K. M.

    2014-12-01

    The Cascadia subduction zone has a history of large magnitude earthquakes, but a near-total lack of plate interface seismicity, making the updip limit of the seismogenic zone difficult to locate. In addition, the central Cascadia accretionary prism is characterized by an extremely low wedge taper angle, landward vergent initial thrusting, and a flat midslope terrace between the inner and outer wedges, unlike most other accretionary prisms (e.g. the Nankai Trough, Japan). The Cascadia Open Access Seismic Transect (COAST) lines were shot by R/V Marcus Langseth in July of 2012 off central Washington to image this subduction zone. Two trench-parallel and nine trench-perpendicular lines were collected. In this study, we present detailed seismic interpretation of both time- and depth-migrated stacked profiles, focused on elucidating the deposition and deformation of both pre- and syn-tectonic sediment in the trench and slope. Distribution and timing of sediments and their deformation is used to unravel the evolution of the wedge through time. Initially, interpretation of the time-sections is carried out to support the building of tomographic velocity models to aid in the pre-stack depth migration (PSDM) of selected lines. In turn, we use PSDM velocity models to estimate porosity and pore pressure conditions at the base of the wedge and across the basal plate interface décollement where possible, using established velocity-porosity transforms. Interpretation in this way incorporates both accurate structural relationships and robust porosity models to document wedge development and present-day stress state, in particular regions of potential overpressure. Results shed light on the origin and evolution of the mid-slope terrace and the low taper angle for the forearc wedge. This work may shed light ultimately on the position of the potential updip limit of the seismogenic zone beneath the wedge.

  14. A Descriptive Comparison of Ultrasound Guided Central Venous Cannulation of the Internal Jugular to Landmark Based Subclavian Vein Cannulation

    PubMed Central

    Theodoro, Daniel; Bausano, Brian; Lewis, Lawrence; Evanoff, Bradley; Kollef, Marin

    2013-01-01

    The safest site for central venous cannulation (CVC) remains debated. Many emergency medicine physicians advocate the ultrasound guided internal jugular approach (USIJ) because of data supporting its efficiency. However, a number of physicians prefer, and are most comfortable with, the subclavian vein approach. The purpose of this study was to describe adverse event rates among operators using the USIJ approach and the landmark subclavian vein approach without ultrasound (SC). Methods This was a prospective observational trial of patients undergoing CVC of the subclavian or internal jugular veins in the Emergency Department (ED). Physicians performing the procedures did not undergo standardized training in either technique. The primary outcome was a composite of adverse events defined as hematoma, arterial cannulation, pneumothorax, and failure to cannulate. Physicians recorded the anatomical site of cannulation, ultrasound assistance, indications and acute complications. Variables of interest were collected from the pharmacy and ED record. Physician experience was based on a self-reported survey. We followed outcomes of central line insertion until device removal or patient discharge. Results Physicians attempted 236 USIJ and 132 SC cannulations on 333 patients. The overall adverse event rate was 22% with failure to cannulate being the most common. Adverse events occurred in 19% of USIJ attempts compared to 29% of non-ultrasound guided subclavian attempts. Among highly experienced operators CVCs placed at the subclavian site resulted in more adverse events than those performed using USIJ (RR=1.89, 95%CI 1.05 to 3.39). Conclusions While limited by observational design, our results suggest that the USIJ technique may result in fewer adverse events compared to the landmark SC approach. PMID:20370781

  15. Future trends of precipitation-related extremes in Central/Eastern Europe based on regional climate model simulations

    NASA Astrophysics Data System (ADS)

    Pongracz, Rita; Bartholy, Judit; Kis, Anna

    2013-04-01

    For building adequate regional adaptation and mitigation strategies, global climate model (GCM) simulation results must be downscaled. Local-scale analysis requires regional climate models (RCMs) embedded in GCMs providing finer spatial and temporal resolutions, which can better serve end-users' needs. This is especially important in case of precipitation due to the large temporal and spatial variability. Furthermore, the high potential risks of drought events on agricultural production and the possible flood events in the Central/Eastern European area also highlight the importance of this issue. On the base of evaluating raw RCM precipitation outputs of ENSEMBLES model experiments for 1951-2000, simulated values usually significantly overestimate the observations in Central/Eastern Europe, except in summer when mostly underestimations were found. These biases of the raw RCM outputs are corrected using quantile matching technique when the monthly empirical distribution functions of each grid point are fitted to the observed distribution (represented by gridded E-OBS data). Then, the calculated bias correcting factors are applied to the outputs of RCM experiments for the future 2000-2100 period taking into account the SRES A1B emission scenario, according to which CO2 concentration by 2100 is estimated to exceed 700 ppm, i.e., more than twice of the preindustrial level. In order to assess precipitation tendencies in the region, several precipitation-related indices (including the number of wet days using several threshold values, e.g. 5 mm, 10 mm, 20 mm; CDD - the maximum number of consecutive dry days; RX1 - the highest 1-day precipitation amount; RX5 - the greatest 5-day rainfall total; etc.) are analyzed both on annual and seasonal scales. The results clearly suggest that consecutive dry periods in the region are likely to lengthen in the future, especially in summer. Furthermore, extreme precipitation is projected to increase in winter and autumn, especially in the northern part of the selected domain.

  16. Nanoparticle-based drug delivery to improve the efficacy of antiretroviral therapy in the central nervous system

    PubMed Central

    Gomes, Maria João; Neves, José das; Sarmento, Bruno

    2014-01-01

    Antiretroviral drug therapy plays a cornerstone role in the treatment of human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome patients. Despite obvious advances over the past 3 decades, new approaches toward improved management of infected individuals are still required. Drug distribution to the central nervous system (CNS) is required in order to limit and control viral infection, but the presence of natural barrier structures, in particular the blood–brain barrier, strongly limits the perfusion of anti-HIV compounds into this anatomical site. Nanotechnology-based approaches may help providing solutions for antiretroviral drug delivery to the CNS by potentially prolonging systemic drug circulation, increasing the crossing and reducing the efflux of active compounds at the blood–brain barrier, and providing cell/tissue-targeting and intracellular drug delivery. After an initial overview on the basic features of HIV infection of the CNS and barriers to active compound delivery to this anatomical site, this review focuses on recent strategies based on antiretroviral drug-loaded solid nanoparticles and drug nanosuspensions for the potential management of HIV infection of the CNS. PMID:24741312

  17. A Central Support System Can Facilitate Implementation and Sustainability of a Classroom-Based Undergraduate Research Experience (CURE) in Genomics

    PubMed Central

    Lopatto, David; Hauser, Charles; Jones, Christopher J.; Paetkau, Don; Chandrasekaran, Vidya; Dunbar, David; MacKinnon, Christy; Stamm, Joyce; Alvarez, Consuelo; Barnard, Daron; Bedard, James E. J.; Bednarski, April E.; Bhalla, Satish; Braverman, John M.; Burg, Martin; Chung, Hui-Min; DeJong, Randall J.; DiAngelo, Justin R.; Du, Chunguang; Eckdahl, Todd T.; Emerson, Julia; Frary, Amy; Frohlich, Donald; Goodman, Anya L.; Gosser, Yuying; Govind, Shubha; Haberman, Adam; Hark, Amy T.; Hoogewerf, Arlene; Johnson, Diana; Kadlec, Lisa; Kaehler, Marian; Key, S. Catherine Silver; Kokan, Nighat P.; Kopp, Olga R.; Kuleck, Gary A.; Lopilato, Jane; Martinez-Cruzado, Juan C.; McNeil, Gerard; Mel, Stephanie; Nagengast, Alexis; Overvoorde, Paul J.; Parrish, Susan; Preuss, Mary L.; Reed, Laura D.; Regisford, E. Gloria; Revie, Dennis; Robic, Srebrenka; Roecklien-Canfield, Jennifer A.; Rosenwald, Anne G.; Rubin, Michael R.; Saville, Kenneth; Schroeder, Stephanie; Sharif, Karim A.; Shaw, Mary; Skuse, Gary; Smith, Christopher D.; Smith, Mary; Smith, Sheryl T.; Spana, Eric P.; Spratt, Mary; Sreenivasan, Aparna; Thompson, Jeffrey S.; Wawersik, Matthew; Wolyniak, Michael J.; Youngblom, James; Zhou, Leming; Buhler, Jeremy; Mardis, Elaine; Leung, Wilson; Threlfall, Jennifer; Elgin, Sarah C. R.

    2014-01-01

    In their 2012 report, the President's Council of Advisors on Science and Technology advocated “replacing standard science laboratory courses with discovery-based research courses”—a challenging proposition that presents practical and pedagogical difficulties. In this paper, we describe our collective experiences working with the Genomics Education Partnership, a nationwide faculty consortium that aims to provide undergraduates with a research experience in genomics through a scheduled course (a classroom-based undergraduate research experience, or CURE). We examine the common barriers encountered in implementing a CURE, program elements of most value to faculty, ways in which a shared core support system can help, and the incentives for and rewards of establishing a CURE on our diverse campuses. While some of the barriers and rewards are specific to a research project utilizing a genomics approach, other lessons learned should be broadly applicable. We find that a central system that supports a shared investigation can mitigate some shortfalls in campus infrastructure (such as time for new curriculum development, availability of IT services) and provides collegial support for change. Our findings should be useful for designing similar supportive programs to facilitate change in the way we teach science for undergraduates. PMID:25452493

  18. A central support system can facilitate implementation and sustainability of a Classroom-based Undergraduate Research Experience (CURE) in Genomics.

    PubMed

    Lopatto, David; Hauser, Charles; Jones, Christopher J; Paetkau, Don; Chandrasekaran, Vidya; Dunbar, David; MacKinnon, Christy; Stamm, Joyce; Alvarez, Consuelo; Barnard, Daron; Bedard, James E J; Bednarski, April E; Bhalla, Satish; Braverman, John M; Burg, Martin; Chung, Hui-Min; DeJong, Randall J; DiAngelo, Justin R; Du, Chunguang; Eckdahl, Todd T; Emerson, Julia; Frary, Amy; Frohlich, Donald; Goodman, Anya L; Gosser, Yuying; Govind, Shubha; Haberman, Adam; Hark, Amy T; Hoogewerf, Arlene; Johnson, Diana; Kadlec, Lisa; Kaehler, Marian; Key, S Catherine Silver; Kokan, Nighat P; Kopp, Olga R; Kuleck, Gary A; Lopilato, Jane; Martinez-Cruzado, Juan C; McNeil, Gerard; Mel, Stephanie; Nagengast, Alexis; Overvoorde, Paul J; Parrish, Susan; Preuss, Mary L; Reed, Laura D; Regisford, E Gloria; Revie, Dennis; Robic, Srebrenka; Roecklien-Canfield, Jennifer A; Rosenwald, Anne G; Rubin, Michael R; Saville, Kenneth; Schroeder, Stephanie; Sharif, Karim A; Shaw, Mary; Skuse, Gary; Smith, Christopher D; Smith, Mary; Smith, Sheryl T; Spana, Eric P; Spratt, Mary; Sreenivasan, Aparna; Thompson, Jeffrey S; Wawersik, Matthew; Wolyniak, Michael J; Youngblom, James; Zhou, Leming; Buhler, Jeremy; Mardis, Elaine; Leung, Wilson; Shaffer, Christopher D; Threlfall, Jennifer; Elgin, Sarah C R

    2014-01-01

    In their 2012 report, the President's Council of Advisors on Science and Technology advocated "replacing standard science laboratory courses with discovery-based research courses"-a challenging proposition that presents practical and pedagogical difficulties. In this paper, we describe our collective experiences working with the Genomics Education Partnership, a nationwide faculty consortium that aims to provide undergraduates with a research experience in genomics through a scheduled course (a classroom-based undergraduate research experience, or CURE). We examine the common barriers encountered in implementing a CURE, program elements of most value to faculty, ways in which a shared core support system can help, and the incentives for and rewards of establishing a CURE on our diverse campuses. While some of the barriers and rewards are specific to a research project utilizing a genomics approach, other lessons learned should be broadly applicable. We find that a central system that supports a shared investigation can mitigate some shortfalls in campus infrastructure (such as time for new curriculum development, availability of IT services) and provides collegial support for change. Our findings should be useful for designing similar supportive programs to facilitate change in the way we teach science for undergraduates. PMID:25452493

  19. Aetiologies of Central Nervous System infections in adults in Kathmandu, Nepal: A prospective hospital-based study

    PubMed Central

    Giri, Abhishek; Arjyal, Amit; Koirala, Samir; Karkey, Abhilasha; Dongol, Sabina; Thapa, Sudeep Dhoj; Shilpakar, Olita; Shrestha, Rishav; van Tan, Le; Thi Thuy Chinh, Bkrong Nguyen; Krishna K. C., Radheshyam; Pathak, Kamal Raj; Shakya, Mila; Farrar, Jeremy; Van Doorn, H. Rogier; Basnyat, Buddha

    2013-01-01

    We conducted a prospective hospital based study from February 2009-April 2011 to identify the possible pathogens of central nervous system (CNS) infections in adults admitted to a tertiary referral hospital (Patan Hospital) in Kathmandu, Nepal. The pathogens of CNS infections were confirmed in cerebrospinal fluid (CSF) using molecular diagnostics, culture (bacteria) and serology. 87 patients were recruited for the study and the etiological diagnosis was established in 38% (n = 33). The bacterial pathogens identified were Neisseria meningitidis (n = 6); Streptococcus pneumoniae (n = 5) and Staphylococcus aureus (n = 2) in 13/87(14%). Enteroviruses were found in 12/87 (13%); Herpes Simplex virus (HSV) in 2/87(2%). IgM against Japanese encephalitis virus (JEV) was detected in the CSF of 11/73 (15%) tested samples. This is the first prospective molecular and serology based CSF analysis in adults with CNS infections in Kathmandu, Nepal. JEV and enteroviruses were the most commonly detected pathogens in this setting. PMID:23924886

  20. Impurity of Stem Cell Graft by Murine Embryonic Fibroblasts Implications for Cell-Based Therapy of the Central Nervous System

    PubMed Central

    Molcanyi, Marek; Mehrjardi, Narges Zare; Schfer, Ute; Haj-Yasein, Nadia Nabil; Brockmann, Michael; Penner, Marina; Riess, Peter; Reinshagen, Clemens; Rieger, Bernhard; Hannes, Tobias; Hescheler, Jrgen; Bosche, Bert

    2014-01-01

    Stem cells have been demonstrated to possess a therapeutic potential in experimental models of various central nervous system disorders, including stroke. The types of implanted cells appear to play a crucial role. Previously, groups of the stem cell network NRW implemented a feeder-based cell line within the scope of their projects, examining the implantation of stem cells after ischemic stroke and traumatic brain injury. Retrospective evaluation indicated the presence of spindle-shaped cells in several grafts implanted in injured animals, which indicated potential contamination by co-cultured feeder cells (murine embryonic fibroblasts MEFs). Because feeder-based cell lines have been previously exposed to a justified criticism with regard to contamination by animal glycans, we aimed to evaluate the effects of stem cell/MEF co-transplantation. MEFs accounted for 5.3??2.8% of all cells in the primary FACS-evaluated co-culture. Depending on the culture conditions and subsequent purification procedure, the MEF-fraction ranged from 0.9 to 9.9% of the cell suspensions in vitro. MEF survival and related formation of extracellular substances in vivo were observed after implantation into the uninjured rat brain. Impurity of the stem cell graft by MEFs interferes with translational strategies, which represents a threat to the potential recipient and may affect the graft microenvironment. The implications of these findings are critically discussed. PMID:25249934

  1. Localization of transcriptional co-activator CBP in the ameloblasts and the other enamel organ-derived cells of the rat incisor.

    PubMed

    Nishikawa, Sumio

    2002-11-01

    CREB-binding protein (CBP) was examined in ameloblasts and in other enamel organ-derived cells of the rat incisor, using Western blotting analysis and immunocytochemistry by specific antibodies. Western blotting of labial tissues, including ameloblasts of the incisors, detected a single band with a molecular weight equivalent to the reported value of CBP. In immunocytochemistry, CBP was localized in ameloblast nuclei in the maturation zone but not in the secretion and transition zones. The nuclei of the other enamel organ-derived cells were also positive. Because this protein is suggested to take part in c-Jun-mediated transcription, the present study and the results of a previous report showing c-Jun localization in the nuclei of enamel organ-derived cells suggest that the enamel organ-derived cells, including maturation ameloblasts, undergo active transcriptional regulation. PMID:12417610

  2. Late Quaternary ostracode-based paleoenvironmental reconstructions from Lake Petn Itz, Guatemala and Lake Chalco, central Mexico

    NASA Astrophysics Data System (ADS)

    Perez, L.; Lozano, S.; Caballero, M.; Brenner, M.; Schwalb, A.

    2013-05-01

    Modern and fossil ostracodes in lakes from central Mexico (Chalco) to lowland Guatemala (Petn Itz) were used to infer paleoenvironmental conditions during the last 45 ka. Ostracode-based paleoenvironmental reconstruction from sediment cores in Lake Petn Itz was based on a modern calibration data set from 63 water bodies in Guatemala, Mexico (Yucatn Peninsula) which provided information on the modern ecological preferences of 29 ostracode species. Statistical analysis indicated that lake water conductivity and chemical composition determine ostracode distributions on the Yucatn Peninsula and that lake level is a strong determinant of species distribution in Lake Petn Itz. Transfer functions were applied to fossil species assemblages in long sediment cores from Lake Petn Itz to infer past conductivity and lake level. Over the past 45 ka, ostracodes in Lake Petn Itz were sensitive to fluctuations in lake water chemical composition and lake stage. Relative abundances of ostracode taxa and stable isotope values in their shells indicate large environmental changes from the LGM to deglaciation, and into the Holocene. The LGM was characterized by low species richness (n=4), dominance of benthic taxa, cold conditions and moderate to high lake levels. The deglaciation displayed higher species richness (n=6), dominance of nektobenthic taxa, and alternating dry and wet conditions, with low to relatively high lake levels. The Holocene was dominated by the deep-water ostracode Physocypria globula, indicating warmer temperatures and higher lake levels. Preliminary results from Lake Chalco sediment cores indicate ostracodes were scarce during the LGM and deglacial, but displayed higher abundances in older deposits. Ostracodes identified in the sediment record include Limnocythere sp., Candona patzcuaro and Darwinula stevensoni. The only species in common with the Lake Petn Itz record is D. stevensoni. Deglacial species richness in Chalco (n=3) was lower than in Lake Petn Itz (n=6). Because the species in Lake Chalco cores differ from those in the Petn Itz record, a training set specifically for central Mexico was developed, using 28 water bodies. About 15 ostracode species have been identified and transfer functions to infer environmental variables will be developed. We will compare stable oxygen and carbon isotope records, measured on fossil ostracode remains in dated cores from Lakes Chalco and Petn Itz, to infer past regional climate conditions.

  3. Causes and prevalence of traumatic injuries to the permanent incisors of school children aged 10-14 years in Maseru, Lesotho.

    PubMed

    Lin, H; Naidoo, Sudeshni

    2008-04-01

    Traumatic dental injuries are widespread in the population and the prevalence of traumatic dental injuries among school children in different parts of the world varies from about 3% to 45%. Most injuries involve the anterior teeth, which may lead to eating restrictions, changes in physical appearance, speech defects and psychological impacts that affect the child's quality of life. A cross-sectional survey was carried out to investigate the prevalence, aetiology and types of injuries to permanent incisors among schoolchildren aged 10-14 years from Maseru, Lesotho. Upper and lower permanent incisors were examined for dental injuries. The prevalence of traumatic injuries to the permanent incisor teeth was 9.3% (13.3% boys and 6.3% girls). Significantly more boys than girls suffered injury. The most common type of injury was enamel fractures and most common cause was falls. Health promotion policies should aim to create an appropriate and safe environment for children. Soft playground surfaces, school-crossing patrols, marked zebra crossings and bicycle lanes would help create a safe environment. Speed limits for cars and the use of seat belts, air bags, special car seats for children and bicycle helmets should be enforced. Mouth guards should be used when playing sport, in particular contact sports. Education regarding the epidemiology of dental injuries and their prevention through health promotion may play a major role in reducing the prevalence of dental injury and avoiding the financial costs of treatment, especially in developing countries. PMID:18689347

  4. Distribution of non-collagenous dentin matrix proteins and proteoglycans, and their relation to calcium accumulation in bisphosphonate-affected rat incisors.

    PubMed

    Ohma, N; Takagi, Y; Takano, Y

    2000-06-01

    It has been reported that multiple injections of 1-hydroxyethylidene- 1,1-bisphosphonate (HEBP) to rats prevent mineralization of incisor dentin, thereby revealing high concentrations of calcium in the non-mineralized matrix of circumpulpal dentin. To identify the molecules responsible for calcium accumulation in circumpulpal dentin matrix, rats were injected daily with HEBP (8 mg P/kg) for 7 d, and the incisors processed for various histochemical and immunohistochemical staining of non-collagenous matrices of dentin. Cuprolinic blue reactions for proteoglycans (PGs) were equally distributed in non-mineralized matrix of mantle and circumpulpal dentin layers. Dentin sialoprotein (DSP) and osteopontin (OPN) immunoreactions were found in non-mineralized circumpulpal dentin matrix, but not in mantle dentin. In normal incisors, however, predentin matrix showing significant DSP immunoreactivity was negative for Ca-GBHA reactions. HEBP-affected, non-mineralized OPN immunopositive bone matrix was also non-reactive for calcium. From these observations, neither PGs, OPN nor DSP appear to be responsible for calcium accumulation in HEBP-affected circumpulpal dentin. Stains-all reactive component, possibly dentin phosphoprotein (DPP), only showed the same distribution as that of Ca-GBHA in both HEBP-affected and normal dentin matrix, implicating a possible contribution of DPP to calcium accumulation in circumpulpal dentin and, hence, to appositional mineralization of dentin. PMID:10872993

  5. The effect of different full-coverage crown systems on fracture resistance and failure pattern of endodontically treated maxillary incisors restored with and without glass fiber posts.

    PubMed

    Salameh, Ziad; Sorrentino, Roberto; Ounsi, Hani F; Sadig, Walid; Atiyeh, Fadi; Ferrari, Marco

    2008-07-01

    The aim of this study was to compare the fracture resistance and failure pattern of endodontically treated maxillary incisors restored using composite resin with or without fiber-reinforced composite (FRC) posts under different types of full-coverage crowns. The null hypothesis tested was that fracture resistance and the failure pattern of these teeth were not affected by the use of FRC posts or by the type of full-coverage crown. One hundred twenty maxillary incisors were endodontically treated and divided into 4 groups of 30 each. Each group was divided into two subgroups: restoration with or without fiber post. PFM crowns were placed in group 1, Empress II crowns in group 2, SR Adoro crowns in group 3, and Cercon crowns in group 4. Fracture tests were performed by loading specimens to fracture. Data were analyzed with two-way analysis of variance (alpha = 0.05). The type of crown was not a significant factor affecting fracture resistance (p = 0.4), whereas the presence of a post was (p = 0.001). Both the presence of post and the type of crown had a significant influence on the proportion of restorable versus unrestorable fractures. Although prosthodontics textbooks do not generally advocate the placement of fiber posts in endodontically treated incisors, the results of this study indicate that the use of fiber posts in such teeth increases their resistance to fracture and improves the prognosis in case of fracture. PMID:18570992

  6. A comparative analysis between site-based and centralized ratings and patient self-ratings in a clinical trial of Major Depressive Disorder.

    PubMed

    Targum, Steven D; Wedel, Pamela C; Robinson, Jill; Daniel, David G; Busner, Joan; Bleicher, Leo S; Rauh, Philip; Barlow, Carrolee

    2013-07-01

    We compared scores from three different ratings methods in a clinical trial of patients with Major Depressive Disorder (MDD). The Quick Inventory of Depressive Symptoms (QIDS-SR16) was compared to site-based clinician and centralized (site-independent) ratings of the Inventory of Depressive Symptoms (IDSc30). An extracted QIDSc16 was used for a matched comparison with the QIDS-SR16. Patient self-ratings were more depressed at baseline than either site-based ratings (p=0.131) or centralized ratings (p=0.005), but significantly less depressed at the end of double-blind treatment than either site-based (p=0.006) or centralized ratings (p=0.014), and after 12 weeks (site-based ratings: p=0.048; centralized ratings: p=0.004). The matched comparisons with patient self-ratings revealed ICC of r=0.55 (site-based raters) and r=0.49 (centralized raters) at baseline. After baseline, the correlations between the two different clinician ratings and patient self-ratings improved to r-values between 0.78 and 0.89. At the end of double-blind treatment, site-based raters separated the combination treatment from placebo on the IDSc30 (p=0.030) whereas neither centralized ratings nor patient self-ratings achieved statistical significance. Alternatively, patient self-ratings separated the combination treatment from buspirone (p=0.030) whereas neither clinician rating method achieved significance. A"dual" scoring concordance range reduced the placebo response rate and increased the drug effect between the combination treatment and placebo. These findings reveal scoring variability between each of the three ratings methods and challenge the reliability of any single method to accurately assess symptom severity scores, particularly at baseline. The use of "dual" scoring criteria may help to confirm symptom severity scores and improve ratings precision, particularly prior to enrolling subjects into CNStrials. PMID:23562150

  7. Base surge deposits, eruption history, and depositional processes of a wet phreatomagmatic volcano in Central Anatolia (Cora Maar)

    NASA Astrophysics Data System (ADS)

    Genalio?lu-Ku?cu, Gonca; Atilla, Cneyt; Cas, Ray A. F.; Ku?cu, ?lkay

    2007-01-01

    Cora Maar is a Quaternary volcano located to the 20 km northwest of Mount Erciyes, the largest of the 19 polygenetic volcanic complexes of the Cappadocian Volcanic Province in central Anatolia. Cora Maar is a typical example of a maar-diatreme volcano with a nearly circular crater with a mean diameter of c.1.2 km, and a well-bedded base surge-dominated maar rim tephra sequence up to 40 m in thickness. Having a diameter/depth ratio ( D/ d) of 12, Cora is a relatively "mature" maar compared to recent maar craters in the world. Cora crater is excavated within the andesitic lava flows of Quaternary age. The tephra sequence is not indurated, and consists of juvenile clasts up to 70 cm, non-juvenile clasts up to 130 cm, accretionary lapilli up to 1.2 cm in diameter, and ash to lapilli-sized tephra. Base surge layers display well-developed antidune structures indicating the direction of the transport. Both progressive and regressive dune structures are present within the tephra sequence. Wavelength values increase with increasing wave height, and with large wavelength and height values. Cora tephra display similarities to Taal and Laacher See base surge deposits. Impact sags and small channel structures are also common. Lateral and vertical facies changes are observed for the dune bedded and planar bedsets. According to granulometric analyses, Cora Maar tephra samples display a bimodal distribution with a wide range of Md ? values, characteristic for the surge deposits. Very poorly sorted, bimodal ash deposits generally vary from coarse tail to fine tail grading depending on the grain size distribution while very poorly sorted lapilli and block-rich deposits display a positive skewness due to fine tail grading.

  8. Application of a process-based shallow landslide hazard model over a broad area in Central Italy

    USGS Publications Warehouse

    Gioia, Eleonora; Speranza, Gabriella; Ferretti, Maurizio; Godt, Jonathan W.; Baum, Rex L.; Marincioni, Fausto

    2015-01-01

    Process-based models are widely used for rainfall-induced shallow landslide forecasting. Previous studies have successfully applied the U.S. Geological Survey’s Transient Rainfall Infiltration and Grid-Based Regional Slope-Stability (TRIGRS) model (Baum et al. 2002) to compute infiltration-driven changes in the hillslopes’ factor of safety on small scales (i.e., tens of square kilometers). Soil data input for such models are difficult to obtain across larger regions. This work describes a novel methodology for the application of TRIGRS over broad areas with relatively uniform hydrogeological properties. The study area is a 550-km2 region in Central Italy covered by post-orogenic Quaternary sediments. Due to the lack of field data, we assigned mechanical and hydrological property values through a statistical analysis based on literature review of soils matching the local lithologies. We calibrated the model using rainfall data from 25 historical rainfall events that triggered landslides. We compared the variation of pressure head and factor of safety with the landslide occurrence to identify the best fitting input conditions. Using calibrated inputs and a soil depth model, we ran TRIGRS for the study area. Receiver operating characteristic (ROC) analysis, comparing the model’s output with a shallow landslide inventory, shows that TRIGRS effectively simulated the instability conditions in the post-orogenic complex during historical rainfall scenarios. The implication of this work is that rainfall-induced landslides over large regions may be predicted by a deterministic model, even where data on geotechnical and hydraulic properties as well as temporal changes in topography or subsurface conditions are not available.

  9. Localization of Core Planar Cell Polarity Proteins, PRICKLEs, in Ameloblasts of Rat Incisors: Possible Regulation of Enamel Rod Decussation

    PubMed Central

    Nishikawa, Sumio; Kawamoto, Tadafumi

    2015-01-01

    To confirm the possible involvement of planar cell polarity proteins in odontogenesis, one group of core proteins, PRICKLE1, PRICKLE2, PRICKLE3, and PRICKLE4, was examined in enamel epithelial cells and ameloblasts by immunofluorescence microscopy. PRICKLE1 and PRICKLE2 showed similar localization in the proliferation and secretory zones of the incisor. Immunoreactive dots and short rods in ameloblasts and stratum intermedium cells were evident in the proliferation to differentiation zone, but in the secretion zone, cytoplasmic dots decreased and the distal terminal web was positive for PRICKLE1 and PRICKLE2. PRICKLE3 and PRICKLE4 showed cytoplasmic labeling in ameloblasts and other enamel epithelial cells. Double labeling of PRICKLE2 with VANGL1, which is another planar cell polarity protein, showed partial co-localization. To examine the transport route of PRICKLE proteins, PRICKLE1 localization was examined after injection of a microtubule-disrupting reagent, colchicine, and was compared with CX43, which is a membrane protein transported as vesicles via microtubules. The results confirmed the retention of immunoreactive dots for PRICKLE1 in the cytoplasm of secretory ameloblasts of colchicine-injected animals, but fewer dots were observed in control animals. These results suggest that PRICKLE1 and PRICKLE2 are transported as vesicles to the junctional area, and are involved in pattern formation of distal junctional complexes and terminal webs of ameloblasts, further implying a role in the formed enamel rod arrangement. PMID:26175546

  10. Effect of intermediate fiber layer on the fracture load and failure mode of maxillary incisors restored with laminate veneers.

    PubMed

    Turkaslan, Suha; Tezvergil-Mutluay, Arzu; Bagis, Bora; Shinya, Akikazu; Vallittu, Pekka K; Lassila, Lippo V

    2008-01-01

    This study evaluated the fracture load and failure mode of various veneer materials cemented with or without the addition of a fiber-reinforced composite (FRC) layer at the adhesive interface. Sixty intact incisors were randomly divided into three groups. Group 1 was fabricated with the heat-press technique (IPS Empress 2); Group 2 with the copy milling technique (ZirkonZahn); and Group 3 with the direct or indirect composite technique (Z250)--and specimens were cemented either with or without FRC at the adhesive interface. The specimens were thermocycled and tested with a universal testing machine. No significant differences in fracture load (p>0.05) were found among the various veneer materials. The addition of FRC at the adhesive layer did not lead to significant differences in the fracture load (p>0.05) but resulted in differences in the failure mode. Laminate veneers made of composite, zirconia, and Empress 2 showed comparable mean fracture loads. However, the use of FRC at the interface changed their failure modes. PMID:18309613

  11. Migrating Ignimbrite Flares in the Central Andes, Implications for Crustal Evolution Based on Chemical, Isotopic, Geochronological, and GIS-Based Volumetric Data

    NASA Astrophysics Data System (ADS)

    Worner, G.; Brandmeier, M.; Freymuth, H.; Heistek, R. M.

    2014-12-01

    Temporal and compositional patterns of Neogene ignimbrites in the Central Andes were analysed using GIS and geostatistical modelling based on 203 digitized ignimbrite sheets for which geochronological, geochemical, and Sr-Nd-Pb-isotopic data on pumices as well as Sr-O isotopes on minerals from selected samples were compiled and compared to compositional and isotopic data from andesite lavas. Composition, timing, volumes and sources of erupted ignimbrite deposits are thus constrained and magma volumes through space and time are calculated. The total erupted ignimbrite magma volume of 31,000 km3 (minimum value) in the past 30 Ma indicate an average magmatic addition of 20-30 km3*Ma/km, similar to the basaltic "base"-flux for arc magmatism. Ignimbrite flare-ups are, however, rather punctuated, short-lived events well separated in space and time. There is a clear N-S "younging" of ignimbrite pulses from N to S at 19-24 Ma, 13-14 Ma, 6-10 Ma and 3-6 Ma. Ignimbrite eruptions occurred in the wake of subduction of the Juan-Fernandez ridge on the Nazca Plate passing below the Central Andes from N to S. Low angle subduction caused compression and fluid release is followed by massive inflow and melting of asthenospheric mantle when the slab steepened again after the passing of the ridge. This in turn caused massive melting within the crust aided by advective heat transport. Differences in chemical and isotopic composition of the large-volume ignimbrites are related to changes in crustal thickness, and different "preconditioning" during the Andean orogeny at a given space in time. Isotope data and whole rock compositional data suggest a higher degree of crustal assimilation for the younger Altiplano ignimbrites in the S (c. 50%) compared to the older (22-19 Ma) ignimbrites in the N were the crustal component is significantly less (20%). REE compositions reflect changes in crustal thickness with a "transition" at c. 13-9 Ma that can be related to accelerated crustal shortening and lower crustal heating at that time. There is no "single" ignimbrite flare up, we suggest a more dynamic scenario, with "flares" moving from N to S across the Central Andes during the past 25 Ma. Our database yield volumes of mantle and crustal magmas produced through time and space and should aid to constrain numerical models of Andean geodynamic processes.

  12. Knowledge-based soil inference modeling for estimating soil productivity and grain yield in north-central Missouri

    Technology Transfer Automated Retrieval System (TEKTRAN)

    We used ArcSIE (Soil Inference Engine) software to model soils resembling those mapped by NRCS soil survey, for eight 12-digit watersheds in the Central Claypan (MLRA113) in north-central Missouri. Our source data for modeling was the 10m USGS Digital Elevation Model. Environmental Covariates used i...

  13. Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli

    PubMed Central

    Wu, Junjun; Du, Guocheng; Chen, Jian; Zhou, Jingwen

    2015-01-01

    The limited supply of intracellular malonyl-CoA in Escherichia coli impedes the biological synthesis of polyketides, flavonoids and biofuels. Here, a clustered regularly interspaced short palindromic repeats (CRISPR) interference system was constructed for fine-tuning central metabolic pathways to efficiently channel carbon flux toward malonyl-CoA. Using synthetic sgRNA to silence candidate genes, genes that could increase the intracellular malonyl-CoA level by over 223% were used as target genes. The efficiencies of repression of these genes were tuned to achieve appropriate levels so that the intracellular malonyl-CoA level was enhanced without significantly altering final biomass accumulation (the final OD600 decreased by less than 10%). Based on the results, multiple gene repressing was successful in approaching the limit of the amount of malonyl-CoA needed to produce the plant-specific secondary metabolite (2S)-naringenin. By coupling the genetic modifications to cell growth, the combined effects of these genetic perturbations increased the final (2S)-naringenin titer to 421.6?mg/L, which was 7.4-fold higher than the control strain. The strategy described here could be used to characterize genes that are essential for cell growth and to develop E. coli as a well-organized cell factory for producing other important products that require malonyl-CoA as a precursor. PMID:26323217

  14. A parameter-free community detection method based on centrality and dispersion of nodes in complex networks

    NASA Astrophysics Data System (ADS)

    Li, Yafang; Jia, Caiyan; Yu, Jian

    2015-11-01

    K-means is a simple and efficient clustering algorithm to detect communities in networks. However, it may suffer from a bad choice of initial seeds (also called centers) that seriously affect the clustering accuracy and the convergence rate. Additionally, in K-means, the number of communities should be specified in advance. Till now, it is still an open problem on how to select initial seeds and how to determine the number of communities. In this study, a new parameter-free community detection method (named K-rank-D) was proposed. First, based on the fact that good initial seeds usually have high importance and are dispersedly located in a network, we proposed a modified PageRank centrality to evaluate the importance of a node, and drew a decision graph to depict the importance and the dispersion of nodes. Then, the initial seeds and the number of communities were selected from the decision graph actively and intuitively as the 'start' parameter of K-means. Experimental results on synthetic and real-world networks demonstrate the superior performance of our approach over competing methods for community detection.

  15. TRMM Based Studies of MJO Convection over the Central Indian Ocean, Maritime Continent, and Western Pacific Warm Pool

    NASA Astrophysics Data System (ADS)

    Rutledge, S. A.; Xu, W.

    2014-12-01

    The structure and organization of precipitating cloud populations related to the initiation and evolution of several MJO events have been fully investigated using data collected from the 2011-2012 DYNAMO field campaign over the Central Indian Ocean (CIO). Since DYNMO monitored the MJO behavior for only a few months, it is important to know how the DYNAMO-recorded characteristics compare to the long-term climatology, such as viewed by TRMM satellite measurements. TRMM observations are also capable of providing the regional variability of the convection as the MJO envelope propagates eastward. The objective of this study is to quantify MJO convective characteristics using 15 years of TRMM satellite measurements over three specific regions affected by the MJO including the CIO, Maritime Continent (MC), and Western Pacific (WP). TRMM data are used to quantify not only the precipitating cloud population categorized by radar echo tops and feature size (as have been previously documented), but also their convective intensity, lightning activity, precipitation structures, bulk microphysical properties, and rainfall contributions. Specifically, the radar, ice scattering (microwave), and lightning observations from TRMM are analyzed for the convective spectrum as a function of MJO stage and geographical location. Furthermore, radar characteristics of MJO events based on TRMM PR are quantitatively compared to that of the shipborne radars deployed during TOGA COARE over the WP and DYNAMO over the CIO.

  16. A MODIS- Based Approach for Crop Yield Prediction in Irrigation Regions of Central Asia Using Light Use Efficiency Modeling

    NASA Astrophysics Data System (ADS)

    Fritsch, Sebastian; Conrad, Christopher, Dech, Stefan

    2010-12-01

    This study describes a MODIS-driven light-use efficiency (LUE) model for irrigated agriculture in a test area of arid Central Asia where there is a high demand for solutions to widespread environmental and economic problems. The model was applied to cotton, winter-wheat and rice and is based on MODIS FPAR time-series, crop maps, meteorological data (temperature, relative humidity, PAR) and crop-specific parameters (growing season, maximum LUE and harvest index). To increase spatial accuracy the MODIS FPAR product was downscaled from 1km to 250m by applying crop-specific linear regressions between NDVI and FPAR. Actual crop production was derived via temperature and water stress terms calculated from meteorological data. Results were compared to official statistics for accuracy assessment. They indicate that the model overestimates crop yields on the regional scale, which is due to scaling issues caused by MODIS data. It is shown that the incorporation of sub-pixel information can account for this drawback.

  17. Anterolateral corridor approach to the infratemporal fossa and central skull base in maxillectomy: rationale and technical aspects.

    PubMed

    McMahon, Jeremy D; Crowther, John; Taylor, William M; Wong, Ling Siew; Paterson, Tom; Devine, John; Wales, Craig; MacIver, Colin

    2015-11-01

    We describe the technical aspects and report our clinical experience of a surgical approach to the infratemporal fossa that aims to reduce local recurrence after operations for cancer of the posterior maxilla. We tested the technique by operating on 3 cadavers and then used the approach in 16 patients who had posterolateral maxillectomy for disease that arose on the maxillary alveolus or junction of the hard and soft palate (maxillary group), and in 19 who had resection of the masticatory compartment and central skull base for advanced sinonasal cancer (sinonasal group). Early proximal ligation of the maxillary artery was achieved in all but one of the 35 patients. Access to the infratemporal fossa enabled division of the pterygoid muscles and pterygoid processes under direct vision in all cases. No patient in the maxillary group had local recurrence at median follow up of 36 months. Four patients (21%) in the sinonasal group had local recurrence at median follow up of 27 months. Secondary haemorrhage from the cavernous segment of the internal carotid artery resulted in the only perioperative death. The anterolateral corridor approach enables controlled resection of tumours that extend into the masticatory compartment. PMID:26212419

  18. Determinants of Cervical Cancer Screening Uptake among Women in Ilorin, North Central Nigeria: A Community-Based Study

    PubMed Central

    Idowu, Ajibola; Olowookere, Samuel Anu; Fagbemi, Aderonke Tolulope; Ogunlaja, Olumuyiwa Ayotunde

    2016-01-01

    Introduction. Cancer of the cervix is the leading cause of cancer deaths among women in developing countries. Screening is one of the most cost effective control strategies for the disease. This study assessed the determinants of cervical cancer screening uptake among Nigerian women. Methodology. This cross-sectional study was conducted using multistage sampling technique among 338 participants in Ilorin, North Central Nigeria. A pretested questionnaire was used for data collection and data analysis was done using SPSS version 21. Chi-square test was used for bivariate analysis while binary logistic regression was used for multivariate analysis. Statistical significance was set at p < 0.05. Results. Only 8.0% of the respondents had ever been screened for cancer of the cervix. The proportion of women who had ever been screened was significantly higher among those who demonstrated positive attitude to screening (81.5%, p = 0.001), respondents who were aware of the disease (100.0%, p = 0.001), and those who were aware of cervical cancer screening (88.9%, p = 0.001). Respondents who had negative attitude had 63% lesser odds of being screened compared to those who had positive attitudes towards screening (AOR; 0.37, 95% CI; 0.01–0.28). Conclusion. There is urgent need to improve the knowledge base and attitude of Nigerian women to enhance cervical cancer screening uptake among them. PMID:26880916

  19. A computer and video display based system for training eccentric viewing in macular degeneration with an absolute central scotoma.

    PubMed

    Frennesson, C; Jakobsson, P; Nilsson, U L

    1995-01-01

    A new approach designed to establish the most suitable area for eccentric viewing and to teach and train patients with severe age-related macular degeneration (AMD) to use the eccentric viewing technique is described. Using a computer and video display based system, as well as software written specifically for this purpose, we investigated and trained ten consecutive patients with AMD. The patients were 80.1 + or - 5.6 years old, on average. All of them had an absolute central scotoma. Mean visual acuity was 0.035 + or - 0.016. After 30 min of testing, instruction and reading on the screen, followed by 2.6 + or - 0.69 one-hour training sessions, on average, with the low vision therapist, reading newspaper and book texts with the aid of hyperoculars or aplanatic systems and a very short reading distance, the patients achieved a reading speed of 58.9 + or - 19.7 words/min, significantly (p<0.001) higher than the initial speed when reading on the screen, 11.5 + or - 4.5 words/min. PMID:8861632

  20. Feasibility study of date (Phoenix dactylifera L.) fruit syrup-based natural jelly using central composite design.

    PubMed

    Benali, Sonia; Benamara, Salem; Bigan, Muriel; Madani, Khodir

    2015-08-01

    A feasibility study of natural fruit jelly from three Algerian raw materials, namely date (Phoenix dactylifera l.) fruit syrup and suspension of orange albedo powder (OAP) in lemon juice (LJ) was performed by response surface methodology (RSM) based on central composite design (CCD). The textural properties of the final jelly were investigated through two dependent variables: hardness and stickiness. The cooking temperature (X1), corresponding to that of thermo stated oil bath, and cooking time (X 2), taken for heating the initial fruit mixture in the oil bath (from ambient temperature without fixing however, the final temperature), were found to be the most influent factors, compared to Brix of date syrup (X3) and temperature (X4) of the cooling stage following the cooking process. Results have also shown that the second-degree polynomial models correctly fit experimental data (R(2), adjusted R(2) (R(2) adj) and cross-validation (Q(2))???1). Considering textural properties of commercial jellies as a reference, it was found that the cooking temperature of 155C for 10min gave a jelly with suitable textural properties. On the other hand, FT-IR spectra revealed that the structure of such jelly was partially close to that of pectin molecules. Finally, the color analysis in the CIELab system of the fruit mixture over the cooking process showed that both lightness (L(*)) and a*/b* ratio were not affected by the experienced temperature range (80-155C). PMID:26243917

  1. Comparative gene expression supports the origin of the incisor and molar process from a single endite in the mandible of the red flour beetle Tribolium castaneum

    PubMed Central

    2013-01-01

    Background The biting edge of the primitive arthropod mandible consists of a biting incisor process and a crushing molar process. These structures are thought to be derived from a structure known as an endite but the precise details of this are not understood. Various hypotheses concerning the number of endites present in the arthropod mandible have been proposed. In the developing embryo, the mandible has an inner and outer lobe that are likely to develop into the incisor and molar processes of the larval mandible; these two lobes are commonly held to be derived from separate endites and to be serially homologous to the galea and lacinia endites of the maxillary appendage respectively (Machida). Results We undertook a study of the development of the embryonic mandible of the beetle Tribolium castaneum using the expression of developmental genes as markers of the developing endites in the mandible and maxilla. The Tribolium ortholog of paired (Tc-prd) has expression domains in the developing maxillary and labial endites as well as the inner and outer lobes of the mandible. Following the expression of Tc-prd in the developing mandible through to late stage embryos shows that the molar and incisor process develop from the inner and outer lobes respectively. In addition to Tc-prd, we compared the expression of genes in the endites of the maxilla to the mandible to draw conclusions about the number of endites in the mandible. Homologs of dachshund are typically expressed in the endites of mandibulate gnathal appendages. Comparison of the expression of Tc-prd, Tribolium dachshund (Tc-dac) and Tribolium wingless (Tc-wg) between the endites of the maxilla and the mandible suggest that, while there are two endites in the maxilla only a single endite is present in the mandible. Conclusions Comparative gene expression suggests that the Tribolium mandible has a single endite from which both mandible lobes are derived. Our results do not support Machida’s hypothesis homologising the incisor and molar processes of the mandible to the galea and lacinia endites of the maxilla. We propose, instead, that both incisor and molar processes are derived from a single endite serially homologous to the lacinia of the maxilla. PMID:23280103

  2. Ocular biometry in the adult population in rural central China: a population-based, cross-sectional study

    PubMed Central

    Fu, Ting; Song, Yin-Wei; Chen, Zhi-Qi; He, Jun-Wen; Qiao, Kun; Sun, Xu-Fang; Zhang, Hong; Wang, Jun-Ming

    2015-01-01

    AIM To describe the distribution and determinants of ocular biometric parameters and to ascertain the relative importance of these determinants in a large population of adults in rural central China. METHODS A population-based, cross-sectional study performed in rural central China included 1721 participants aged 40 or more years. Ocular biometrical parameters including axial length (AL), anterior chamber depth (ACD), radius of corneal curvature (K) and horizontal corneal diameter [white-to-white (WTW) distance] were measured using non-contact partial coherence interferometry [intraocular lens (IOL)-Master]. RESULTS Ocular biometric data on 1721 participants with a average age of 57.0±8.7y were analyzed at last. The general mean AL, ACD, mean corneal curvature radius (MCR), WTW were 22.80±1.12, 2.96±0.36, 7.56±0.26 and 11.75±0.40 mm, respectively. The mean values of each parameter in 40 to 49, 50 to 59, 60 to 69, and 70 to 91 years age groups were as follows: AL, 22.77±0.87, 22.76±1.06, 22.89±1.41, 22.92±0.80 mm; ACD, 3.10±0.32, 2.98±0.34, 2.86±0.36, 2.77±0.35 mm; MCR, 7.58±0.25, 7.54±0.26, 7.55±0.26, 7.49±0.28 mm; WTW, 11.79±0.38, 11.75±0.40, 11.72±0.41, 11.67±0.41 mm. The AL, ACD, MCR and WTW were correlated with age and the AL was correlated with height and weight. CONCLUSION Our findings can serve as an important normative reference for multiple purposes and may help to improve the quality of rural eye care. PMID:26309884

  3. A GIS-based Spatial Analysis of Volcanoes in the Central Andes: Insights Into Factors Controlling Volcano Spacing.

    NASA Astrophysics Data System (ADS)

    Savant, S. S.; de Silva, S. L.

    2005-12-01

    Volcano spacing has received little attention since the mid-70's when studies undertaken by Vogt (1974; EPSL) and then Marsh (1979; J Geol) suggested a regular spacing of volcanoes in arcs that ranged from 50 to 75 km for different arcs. The spacing was thought to be influenced by the thickness of the lithosphere or gravitational (Rayleigh-Taylor) instabilities related to source layer thickness and viscosity respectively. We have revisited these ideas through a detailed study of volcano distribution in the Central Volcanic Zone (CVZ) of the Andes where volcano spacing was thought to be around 70 km. The CVZ was selected as it is the type example of continental arc volcanism, built on an extremely thick crust of up to 70 km. The availability of a comprehensive dataset describing the relative age, location, and geomorphic characteristics of each volcano (Volcanoes of the Central Andes, de Silva and Francis, 1990, Springer Verlag) made this a compelling case study. The ready availability of ARC GIS Geographic Information Systems software and the geospatial analysis tools therein, allowed a comprehensive spatial analysis of the volcanoes to be conducted. Of the 1,118 volcanoes of ages from 23Ma to active in the CVZ, we focused on the 106 active and potentially active large composite volcanoes that define the modern arc. These volcanoes are related in time and thus to a consistent set of tectonic factors. The frequency distribution of inter-volcano distances shows a peak frequency in the 10 - 30 km range (71%) with subordinate between 40-80 km (19%) and 80 - 120 km (10%). The characteristic spacing is thus much smaller than the characteristic spacing of 70 km found previously and is consistent with Baker (1974; EPSL). The primary cause appears to be clustering of volcanoes into groups. The density of volcanoes is variable along the arc with regularly spaced clusters of two to three volcanoes in northern and southern parts of the arc (13 r°S to 19 r°S and 24 r° to 27 r°S). The central part of the arc between 22 r° and 24 r°S shows the highest density of volcanoes. An interpolated continuous raster grid of volcano base elevation revealed a strong positive correlation with the density of volcanoes. Interestingly, the spacing of the peaks in density is fairly regular at about 75 to 110 km. We interpret the different orders of spacing as reflecting control by different levels within the plumbing system for the arc. The spacing of density peaks (clusters) is likely the primary spacing of diapirs rising from the source layer into the lithosphere. The dominant 10 to 30 km spacing of individual volcanoes probably reflects the influence of intra-crustal regions superimposed on the primary spacing. These regions may be mid-crustal, low-velocity, high-conductivity zones that have been imaged geophysically and/or the influence of older upper crustal batholiths that may have been emplaced into the thickest crust between 22 r° and 24 r°S.

  4. Central Odontogenic Fibroma of the Gingiva: A Case Report

    PubMed Central

    Soolari, Ahmad; Khan, Asghar

    2015-01-01

    In this paper, we present a case of an uncommon and slow-growing tumor known as a central odontogenic fibroma (COF). The patient in question is a 53-year-old African-American man who was referred for periodontal evaluation of asymptomatic space formation between the mandibular central incisors. Clinical and radiological evaluations disclosed tumor-like tissue expanding the alveolar ridge in the buccolingual dimension, along with thinning of the cortical plates. Surgical excision was performed, and the specimen was sent for histopathology, which later confirmed that the lesion was a COF. Periodontal regenerative therapy was performed to rebuild the hard and soft tissue that had been compromised as a result of tumor expansion. The site was grafted, with excellent results. PMID:25646136

  5. Preliminary Results of the Active Source Portion of the Bighorns Array Seismic Experiment (BASE), North-Central Wyoming, USA

    NASA Astrophysics Data System (ADS)

    Terbush, B. R.; Worthington, L. L.; Miller, K. C.; Harder, S. H.; Erslev, E.; Anderson, M. L.; Siddoway, C. S.

    2010-12-01

    The Bighorn Arch Seismic Experiment (BASE), is designed to image the Bighorn Arch in North Central Wyoming using active and passive seismic methods. The Bighorn Mountains formed as a basement involved foreland arch during the Laramide Orogeny. Whereas such arches are major features of both modern and ancient contractional orogens, the manifestation of arch shortening at depth has been highly contested due to the absence of detailed geophysical imaging of crust and mantle beneath the arches. BASE is a component of an integrated geological-geophysical program, the Bighorns Project, focused on discovering the nature of features that accommodate shortening at depth in such orogens. The active component of BASE was conducted in two deployments during the summer of 2010 and was designed to image the crust and upper mantle of the region. During the first deployment, ca. 1800 single channel Texan seismographs were deployed at 100 and 500 m spacings along a north-south profile located on the west flank of the Bighorn Mountains and along an east-west profile that extended across the arch from near Cody, Wyoming to north of Gillette, Wyoming. The seismograph array recorded blasts at 16 locations over two nights. The second deployment recorded 8 shots on ~800 Texan seismographs deployed at 200 and 1000 m spacings along the same north-south and east-west profiles. These shots were also recorded by ~400 additional Texans seismographs with 1 km spacing on a larger grid that encompassed the entire arch. Preliminary review of the data shows that shot energy propagated to offsets as great as 270 km and that large delays and advances in first arrival times correlate with the location of basins and exposed basement rocks respectively. Early one-dimensional velocity models show that the crystalline crust has velocities of 6.1 to 6.5 km/s to depths of ca 22 km, below which velocities increase from 6.8 to 7.0 km/s Crustal thickness appears to vary between 35 and 45 km. Future work includes developing velocity models from seismic tomography that will show what type of basement structures exist beneath the mountains, and, after integration with other datasets, how their geometries change in two- and three-dimensions.

  6. Mapping hydrological environments in central Amazonia: ground validation and surface model based on SRTM DEM data corrected for deforestation

    NASA Astrophysics Data System (ADS)

    Moulatlet, G. M.; Rennó, C. D.; Costa, F. R. C.; Emilio, T.; Schietti, J.

    2015-03-01

    One of the most important freely available digital elevation models (DEMs) for Amazonia is the one obtained by the Shuttle Radar Topography Mission (SRTM). However, since SRTM tends to represent the vegetation surface instead of the ground surface, the broad use of SRTM DEM as a framework for terrain description in Amazonia is hampered by the presence of deforested areas. We present here two data sets: (1) a deforestation-corrected SRTM DEM for the interfluve between the Purus and Madeira rivers, in central Amazonia, which passed through a careful identification of different environments and has deforestation features corrected by a new method of increasing pixel values of the DEM (Rennó, 2009); and (2) a set of 18 hydrological-topographic descriptors based on the corrected SRTM DEM. Deforestation features are related with the opening of an 800 km road in the central part of the interfluve and occupancy of its vicinity. We used topographic profiles from the pristine forest to the deforested feature to evaluate the recovery of the original canopy coverage by minimizing canopy height variation (corrections ranged from 1 to 38 m). The hydrological-topographic description was obtained by the Height Above the Nearest Drainage (HAND) algorithm, which normalizes the terrain elevation (above sea level) by the elevation of the nearest hydrologically connected drainage. The validation of the HAND data set was done by in situ hydrological description of 110 km of walking trails also available in this data set. The new SRTM DEM expands the applicability of SRTM data for landscape modelling; the data sets of hydrological features based on topographic modelling are undoubtedly appropriate for ecological modelling and an important contribution to environmental mapping of Amazonia. The deforestation-corrected SRTM DEM is available at http://ppbio.inpa.gov.br/knb/metacat/naman.318.3/ppbio; the polygons selected for deforestation correction are available at http://ppbio.inpa.gov.br/knb/metacat/naman.317.3/ppbio; the set of hydrological-topographic descriptors is available at http://ppbio.inpa.gov.br/knb/metacat/naman.544.2/ppbio; the environmental description of access trails is available at http://ppbio.inpa.gov.br/knb/metacat/naman.541.2/ppbio; and the limits of deforestation corrections and drainage validation are available at http://ppbio.inpa.gov.br/knb/metacat/liliandias.38.1/ppbio.

  7. Detection of planets in extremely weak central perturbation microlensing events via next-generation ground-based surveys

    SciTech Connect

    Chung, Sun-Ju; Lee, Chung-Uk; Koo, Jae-Rim E-mail: leecu@kasi.re.kr

    2014-04-20

    Even though the recently discovered high-magnification event MOA-2010-BLG-311 had complete coverage over its peak, confident planet detection did not happen due to extremely weak central perturbations (EWCPs, fractional deviations of ≲ 2%). For confident detection of planets in EWCP events, it is necessary to have both high cadence monitoring and high photometric accuracy better than those of current follow-up observation systems. The next-generation ground-based observation project, Korea Microlensing Telescope Network (KMTNet), satisfies these conditions. We estimate the probability of occurrence of EWCP events with fractional deviations of ≤2% in high-magnification events and the efficiency of detecting planets in the EWCP events using the KMTNet. From this study, we find that the EWCP events occur with a frequency of >50% in the case of ≲ 100 M {sub E} planets with separations of 0.2 AU ≲ d ≲ 20 AU. We find that for main-sequence and sub-giant source stars, ≳ 1 M {sub E} planets in EWCP events with deviations ≤2% can be detected with frequency >50% in a certain range that changes with the planet mass. However, it is difficult to detect planets in EWCP events of bright stars like giant stars because it is easy for KMTNet to be saturated around the peak of the events because of its constant exposure time. EWCP events are caused by close, intermediate, and wide planetary systems with low-mass planets and close and wide planetary systems with massive planets. Therefore, we expect that a much greater variety of planetary systems than those already detected, which are mostly intermediate planetary systems, regardless of the planet mass, will be significantly detected in the near future.

  8. Airborne pollen-climate relationship based on discriminant analysis in Nam Co, Central Tibet and its palaeoenvironmental significance

    NASA Astrophysics Data System (ADS)

    Lyu, X.; Zhu, L.; Ma, Q.; Li, Q.

    2014-12-01

    Based on the airborne pollen data collected using a Burkard pollen trap, discriminant analysis were conducted to evaluate the relationship between two different atmospheric circulation systems, the Asia summer monsoon (ASM) and the Westerlies, in Nam Co basin, central Tibet. The whole year's samples could be classified into two groups using cluster analysis: one group was from May to September, another group was from October to April of next year, corresponding to monsoon period and non-monsoon period, respectively. The classification represents two different atmospheric circulation systems, ASM in monsoon period and the Westerlies in non-monsoon period. Discriminant analysis was performed. First, the whole year samples were divided into two a priori groups, group A is monsoon period (May-Sep.) and group B is non-monsoon period (Oct.-Apr.). Then percentage data of major pollen taxa were used to establish the discriminant functions, and then the samples were classified into predicted groups. The results of discriminant analysis show that 78.6% of the samples were cross-validated grouped correctly. Thus, airborne pollen assemblages can distinguish two different climate systems: monsoon period and non-monsoon period. According to the discriminant score, the group centroids of group A and group B were negative and positive, respectively. Therefore, we created the discriminant score as a new monsoon index (PDI, Pollen Discriminant Index), small PDI values represented enhanced summer monsoon climate. Using above result, we calculated the PDI of Nam Co NCL core, the PDI values can be coincided with Dryness (moisture indicator) and A/Cy ratio (temperature indicator).

  9. Modelling soil moisture spatial-temporal variability with 3-D physically-based hdrological model in central Italy

    NASA Astrophysics Data System (ADS)

    Formetta, Giuseppe; Brocca, Luca; Camici, Stefania; Capparelli, Giovanna; Rigon, Riccardo

    2015-04-01

    Soil water content (SWC) evolution in space and in time influences many hydrological processes such as infiltration and run-off production, surface energy exchanges, floods and drought generation and propagation, triggering of shallow landslide. Modeling SWC is a complex task influenced by heterogeneity in precipitation, soil parameters, topography, and vegetation. In order to consider these different factors we used a three-dimensional process based hydrological model that solves the 3-D Richard equations, coupled with atmospheric energy exchanges, considering the radiative and turbulent fluxes. For the purposes of this study we modeled the surface SWC dynamics (of top 10-15 cm of soil) in a 60 km watershed located in central Italy (Vallaccia catchment). In the basin were available: i) SWC measured continuously at hourly time step for 3-years (2002-2005), and ii) 35 daily SWC measures carried out within one year (from Nov-2006 to Nov-2007) in seven different fields consisting in a regular grid configuration of five by six nodes (grid-step of 10 m). Two were the objectives of the study. Firstly, the calibration of model parameters (hydraulic conductivity and van Genuchten parameters) in order to simulate long term SWC dynamics in time. The two long-term SWC time-series were split in two and used for model calibration and verification, respectively. Model performances reaches values of Kling-Gupta Efficiency of 0.85 in calibration and 0.78 in verification period, giving confidence of reliability for the estimation of the ungauged points. The second objective was the reproduction of SWC patterns in space in the seven different fields where measurements were collected. For each field, modeled and measured statistical moments (from the first to the fourth: mean, variance, skewness and kurtosis) were presented in the form of scatterplots and influence of the variability of the hydraulic conductivity in space on the overall SWC distribution was investigated by generation of different random-fields correlated in space.

  10. Structure-based functional characterization of repressor of toxin (Rot), a central regulator of staphylococcus aureus virulence

    DOE PAGESBeta

    Killikelly, April; Jakoncic, Jean; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Spurrier, Brett; Torres, Victoer J.; Kong, Xian -Peng

    2014-10-20

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure ofmore » Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. As a result, this work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus.« less

  11. Field based measurements of albedo for two candidate perennial cellulosic feedstocks and row crops in Central Illinois

    NASA Astrophysics Data System (ADS)

    Miller, J. N.; VanLoocke, A.; Bernacchi, C. J.

    2012-12-01

    The production of perennial cellulosic feedstocks for bioenergy present the potential to diversify regional economies and the national energy supply, while also serving as a climate 'regulators' due to a number of biogeochemical and biophysical differences relative to row crops. Numerous observationally and modeling based approaches, including life cycle analyses have investigated biogeochemical tradeoffs, such as increased carbon sequestration and biophysical increased water use, associated with growing cellulosic feedstocks. A less understood aspect is the biophysical changes associated with the difference in albedo, which will alter the local energy balance and could cause a local to regional cooling several times larger than that associated with offsetting carbon. To address this factor an experiment consisting of paired fields of Miscanthus and Switchgrass, two of the leading perennial cellulosic feedstock candidates, and traditional row crops was established in central Illinois. Data from the first two growing seasons indicate that this effect is most pronounced during the spring and fall as perennial biofuel crops green up earlier and senesce later than common annual row crops. The albedo of the perennials converges to that of the row crops during the growing season as the canopies develop. During the early winter, before the perennial crops are harvested, the albedo over fallow soybean and maize fields can vary greatly depending on snowfall and, to a lesser extent, soil moisture, whereas perennials show less variation. Thus, perennial biofuel crops also have the potential to buffer the local environment against short-term variations in climate. These factors should be considered when evaluating the tradeoffs and climate-regulation services associated with large-scale planting of bioenergy crops.

  12. Structure-Based Functional Characterization of Repressor of Toxin (Rot), a Central Regulator of Staphylococcus aureus Virulence

    PubMed Central

    Killikelly, April; Benson, Meredith A.; Ohneck, Elizabeth A.; Sampson, Jared M.; Jakoncic, Jean; Spurrier, Brett

    2014-01-01

    Staphylococcus aureus is responsible for a large number of diverse infections worldwide. In order to support its pathogenic lifestyle, S. aureus has to regulate the expression of virulence factors in a coordinated fashion. One of the central regulators of the S. aureus virulence regulatory networks is the transcription factor repressor of toxin (Rot). Rot plays a key role in regulating S. aureus virulence through activation or repression of promoters that control expression of a large number of critical virulence factors. However, the mechanism by which Rot mediates gene regulation has remained elusive. Here, we have determined the crystal structure of Rot and used this information to probe the contribution made by specific residues to Rot function. Rot was found to form a dimer, with each monomer harboring a winged helix-turn-helix (WHTH) DNA-binding motif. Despite an overall acidic pI, the asymmetric electrostatic charge profile suggests that Rot can orient the WHTH domain to bind DNA. Structure-based site-directed mutagenesis studies demonstrated that R91, at the tip of the wing, plays an important role in DNA binding, likely through interaction with the minor groove. We also found that Y66, predicted to bind within the major groove, contributes to Rot interaction with target promoters. Evaluation of Rot binding to different activated and repressed promoters revealed that certain mutations on Rot exhibit promoter-specific effects, suggesting for the first time that Rot differentially interacts with target promoters. This work provides insight into a precise mechanism by which Rot controls virulence factor regulation in S. aureus. PMID:25331435

  13. The Lilongwe Central Hospital Patient Management Information System: A Success in Computer-Based Order Entry Where One Might Least Expect It

    PubMed Central

    GP, Douglas; RA, Deula; SE, Connor

    2003-01-01

    Computer-based order entry is a powerful tool for enhancing patient care. A pilot project in the pediatric department of the Lilongwe Central Hospital (LCH) in Malawi, Africa has demonstrated that computer-based order entry (COE): 1) can be successfully deployed and adopted in resource-poor settings, 2) can be built, deployed and sustained at relatively low cost and with local resources, and 3) has a greater potential to improve patient care in developing than in developed countries. PMID:14728338

  14. Effects of CO2 laser irradiation in vivo on rat alveolar bone and incisor enamel, dentin, and pulp.

    PubMed

    McKee, M D

    1993-10-01

    Previous studies have shown that a surgical 'window' can be drilled in alveolar bone for experimental manipulation of the underlying enamel organ and enamel. To determine whether similar and/or improved access could be obtained by use of the surgical capabilities of laser optics, and to note the effects of laser irradiation in vivo on the extracellular matrices and cells of bone, enamel, and dentin, tissue responses to laser-created lesions were examined histologically. Briefly, samples were prepared in which the alveolar bone along the inferior mandibular border of Wistar rats was exposed, and a continuous-wave CO2 laser equipped with a custom-made micromanipulator was used to penetrate the bone and to create lesions within the lower incisor. Animals were perfusion-fixed at either 10 min or 10 days post-treatment, and affected tissues were processed for light and transmission electron microscopy. At 10 min, all lesions consisted of a void of ablated tissue containing some organic debris. Tissues immediately surrounding the lesion were generally intact, but showed some damage, presumably resulting from elevated temperature effects. At 10 days, lesions in the bone, dentin, odontoblast layer, or pulp showed morphological evidence of tissue repair represented by the presence of cell infiltrates, new bone, or reparative dentin. In lesions that were created during the secretory stage of amelogenesis that had moved into the maturation stage, there was evidence of delayed or incomplete maturation of enamel (i.e., retention of organic matrix normally lost during maturation) related to the enamel organ affected by the laser treatment. In the bone lesion at 10 days, new bone formation was observed, while bone fragments originally created at the time of lasing were surrounded by mononuclear and large multinucleated giant cells. It is thus concluded that the application of this laser system is an alternative method for exposing unerupted dental tissues for experimental manipulation, and that laser irradiation may also be useful for the study of mineralized tissue repair. PMID:8408883

  15. Mapping hydrological environments in central Amazonia: ground validation and surface model based on SRTM DEM data corrected for deforestation

    NASA Astrophysics Data System (ADS)

    Moulatlet, G. M.; Rennó, C. D.; Costa, F. R. C.; Emilio, T.; Schietti, J.

    2014-07-01

    One of the most important freely available digital elevation models (DEMs) for Amazonia is the one obtained by the Shuttle Radar Topography Mission (SRTM). However, since SRTM tends to represent the vegetation surface instead of the ground surface, the broad use of SRTM DEM as a framework for terrain description in Amazonia is hampered by the presence of deforested areas. We present here two datasets: (1) a deforestation-corrected SRTM DEM for the interfluve between the Purus and Madeira rivers, in central Amazonia, which passed through a careful identification of different environments and has deforestation features corrected by a new method of increasing pixel values of the DEM; and (2) a set of eighteen hydrological-topographic descriptors based on the corrected SRTM DEM. The hydrological-topographic description was generated by the Height Above the Nearest Drainage (HAND) algorithm, which normalizes the terrain elevation (a.s.l.) by the elevation of the nearest hydrologically connected drainage. The validation of the HAND dataset was done by in situ hydrological description of 110 km of walking trails also available in this dataset. The new SRTM DEM expands the applicability of SRTM data for landscape modelling; and the datasets of hydrological features based on topographic modelling is undoubtedly appropriate for ecological modelling and an important contribution for environmental mapping of Amazonia. The deforestation-corrected SRTM DEM is available at http://ppbio.inpa.gov.br/knb/metacat/naman.318.3/ppbio; the polygons selected for deforestation correction are available at http://ppbio.inpa.gov.br/knb/metacat/naman.317.3/ppbio; the set of hydrological-topographic descriptors is available at http://ppbio.inpa.gov.br/knb/metacat/naman.544.2/ppbio; and the environmental description of access trails is available at http://ppbio.inpa.gov.br/knb/metacat/naman.541.2/ppbio.

  16. ScienceCentral: open access full-text archive of scientific journals based on Journal Article Tag Suite regardless of their languages.

    PubMed

    Huh, Sun

    2013-01-01

    ScienceCentral, a free or open access, full-text archive of scientific journal literature at the Korean Federation of Science and Technology Societies, was under test in September 2013. Since it is a Journal Article Tag Suite-based full text database, extensible markup language files of all languages can be presented, according to Unicode Transformation Format 8-bit encoding. It is comparable to PubMed Central: however, there are two distinct differences. First, its scope comprises all science fields; second, it accepts all language journals. Launching ScienceCentral is the first step for free access or open access academic scientific journals of all languages to leap to the world, including scientific journals from Croatia. PMID:24266292

  17. ScienceCentral: open access full-text archive of scientific journals based on Journal Article Tag Suite regardless of their languages

    PubMed Central

    Huh, Sun

    2013-01-01

    ScienceCentral, a free or open access, full-text archive of scientific journal literature at the Korean Federation of Science and Technology Societies, was under test in September 2013. Since it is a Journal Article Tag Suite-based full text database, extensible markup language files of all languages can be presented, according to Unicode Transformation Format 8-bit encoding. It is comparable to PubMed Central: however, there are two distinct differences. First, its scope comprises all science fields; second, it accepts all language journals. Launching ScienceCentral is the first step for free access or open access academic scientific journals of all languages to leap to the world, including scientific journals from Croatia. PMID:24266292

  18. Central line complications

    PubMed Central

    Kornbau, Craig; Lee, Kathryn C; Hughes, Gwendolyn D; Firstenberg, Michael S

    2015-01-01

    Central venous access is a common procedure performed in many clinical settings for a variety of indications. Central lines are not without risk, and there are a multitude of complications that are associated with their placement. Complications can present in an immediate or delayed fashion and vary based on type of central venous access. Significant morbidity and mortality can result from complications related to central venous access. These complications can cause a significant healthcare burden in cost, hospital days, and patient quality of life. Advances in imaging, access technique, and medical devices have reduced and altered the types of complications encountered in clinical practice; but most complications still center around vascular injury, infection, and misplacement. Recognition and management of central line complications is important when caring for patients with vascular access, but prevention is the ultimate goal. This article discusses common and rare complications associated with central venous access, as well as techniques to recognize, manage, and prevent complications. PMID:26557487

  19. Neuroarchitecture and neuroanatomy of the Drosophila central complex: A GAL4-based dissection of protocerebral bridge neurons and circuits

    PubMed Central

    Wolff, Tanya; Iyer, Nirmala A; Rubin, Gerald M

    2015-01-01

    Insects exhibit an elaborate repertoire of behaviors in response to environmental stimuli. The central complex plays a key role in combining various modalities of sensory information with an insect's internal state and past experience to select appropriate responses. Progress has been made in understanding the broad spectrum of outputs from the central complex neuropils and circuits involved in numerous behaviors. Many resident neurons have also been identified. However, the specific roles of these intricate structures and the functional connections between them remain largely obscure. Significant gains rely on obtaining a comprehensive catalog of the neurons and associated GAL4 lines that arborize within these brain regions, and on mapping neuronal pathways connecting these structures. To this end, small populations of neurons in the Drosophila melanogaster central complex were stochastically labeled using the multicolor flip-out technique and a catalog was created of the neurons, their morphologies, trajectories, relative arrangements, and corresponding GAL4 lines. This report focuses on one structure of the central complex, the protocerebral bridge, and identifies just 17 morphologically distinct cell types that arborize in this structure. This work also provides new insights into the anatomical structure of the four components of the central complex and its accessory neuropils. Most strikingly, we found that the protocerebral bridge contains 18 glomeruli, not 16, as previously believed. Revised wiring diagrams that take into account this updated architectural design are presented. This updated map of the Drosophila central complex will facilitate a deeper behavioral and physiological dissection of this sophisticated set of structures. J. Comp. Neurol. 523:9971037, 2015. 2014 Wiley Periodicals, Inc. PMID:25380328

  20. Focal Image Plane Detection Based on Central Coordinate Point Spectral Value in Off-Axis Digital Particle Holography

    NASA Astrophysics Data System (ADS)

    Qiu, Peizhen; Deng, Lijun; Lu, Wenhui

    2015-12-01

    A method to detect the focal image plane from a single off-axis digital particle hologram is proposed. This method utilizes the central coordinate point spectral value of the reconstructed particle image as focusing criterion to detect the focal image plane. It is found that the central coordinate point spectral values come into maximum when the reconstruction distance is equal to the actual distance that was used in experiment of hologram acquisition. Numerical simulations are given to validate the feasibility and effectiveness of the proposed method. The proposed method is a potential and better option for studying three dimensional particles by using digital holography.

  1. The atyid shrimps from Lake Lindu, Central Sulawesi, Indonesia with description of two new species (Crustacea: Decapoda: Caridea).

    PubMed

    Annawaty; Wowor, Daisy

    2015-01-01

    The atyid shrimp Caridina linduensis Roux, 1904, has not been reported since its description more than a century ago. We here redescribe and figure this poorly known species based on new material from its type locality, Lake Lindu, Central Sulawesi, Indonesia. Two new species, C. dali sp. nov. and C. kaili sp. nov. are also found in this lake and they are described and illustrated. Compared to C. linduensis, C. dali sp. nov. is distinguished by its relatively shorter rostrum which only overreaches the end of basal segment of antennular peduncle and the fewer teeth on the incisor process of the mandible. Caridina kaili sp. nov. can be separated from C. linduensis by its extremely short rostrum, which reaches almost or just reaches the end of the basal segment of the antennular peduncle, proportionately stouter second pereiopod and larger egg size. The two new species also prefer different habitats; C. linduensis is a true lake inhabitant, C. dali sp. nov. can be found both in the lake itself and associated streams while C. kaili sp. nov. is an obligate stream species. PMID:26249092

  2. Adapting to Climate Variability and Change: Experiences from Cereal-Based Farming in the Central Rift and Kobo Valleys, Ethiopia

    NASA Astrophysics Data System (ADS)

    Kassie, Belay Tseganeh; Hengsdijk, Huib; Rötter, Reimund; Kahiluoto, Helena; Asseng, Senthold; Van Ittersum, Martin

    2013-11-01

    Small-holder farmers in Ethiopia are facing several climate related hazards, in particular highly variable rainfall with severe droughts which can have devastating effects on their livelihoods. Projected changes in climate are expected to aggravate the existing challenges. This study examines farmer perceptions on current climate variability and long-term changes, current adaptive strategies, and potential barriers for successful further adaptation in two case study regions—the Central Rift Valley (CRV) and Kobo Valley. The study was based on a household questionnaire, interviews with key stakeholders, and focus group discussions. The result revealed that about 99 % of the respondents at the CRV and 96 % at the Kobo Valley perceived an increase in temperature and 94 % at CRV and 91 % at the Kobo Valley perceived a decrease in rainfall over the last 20-30 years. Inter-annual and intraseasonal rainfall variability also has increased according to the farmers. The observed climate data (1977-2009) also showed an increasing trend in temperature and high inter-annual and intra-seasonal rainfall variability. In contrast to farmers’ perceptions of a decrease in rainfall totals, observed rainfall data showed no statistically significant decline. The interaction among various bio-physical and socio-economic factors, changes in rainfall intensity and reduced water available to crops due to increased hot spells, may have influenced the perception of farmers with respect to rainfall trends. In recent decades, farmers in both the CRV and Kobo have changed farming practices to adapt to perceived climate change and variability, for example, through crop and variety choice, adjustment of cropping calendar, and in situ moisture conservation. These relatively low-cost changes in farm practices were within the limited adaptation capacity of farmers, which may be insufficient to deal with the impacts of future climate change. Anticipated climate change is expected to impose new risks outside the range of current experiences. To enable farmers to adapt to these impacts critical technological, institutional, and market-access constraints need to be removed. Inconsistencies between farmers’ perceptions and observed climate trends (e.g., decrease in annual rainfall) could lead to sub-optimal or counterproductive adaptations, and therefore must be removed by better communication and capacity building, for example through Climate Field Schools. Enabling strategies, which are among others targeted at agricultural inputs, credit supply, market access, and strengthening of local knowledge and information services need to become integral part of government policies to assist farmers to adapt to the impacts of current and future climate change.

  3. PROGNOSTIC FACTORS FOR PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMAS TREATED WITH HIGH-DOSE METHOTREXATE-BASED CHEMO-RADIOTHERAPY

    PubMed Central

    Nagane, Motoo; Lee, Jeunghun; Shishido-Hara, Yukiko; Suzuki, Kaori; Shimizu, Saki; Umino, Michiru; Kobayashi, Keiichi; Shiokawa, Yoshiaki

    2014-01-01

    BACKGROUND: Chemotherapy with high-dose methotrexate (HD-MTX) followed by whole brain radiotherapy (WBRT) is a conventional approach to treat primary central nervous system lymphomas (PCNSL), but some tumors relapse early leading to unfavorable outcome. Several biomarkers have been identified as prognostic factors in PCNSL, however, the correlation of both clinical factors including those related to MTX metabolism and B-cell differentiation and oncogenic biomarkers with response to and outcome by therapy is yet unclear. METHODS: We investigated 32 immunocompetent patients (19 males, 13 females) with PCNSL (all diffuse large B-cell type) treated with HD-MTX based therapy with or without WBRT since 2000 in our institution. Paraffin-embedded formalin-fixed tumor tissue sections were stained immunohistochemically with antibodies against following factors: B-cell differentiation markers (CD10, Bcl-6, Mum-1, CD138); MTX metabolism-related (MRP family, LRP, DHFR); cell cycle-related (p27KIP1, MIB-1); drug resistance-related (MGMT, MLH1, MSH2, MSH6, PMS2); and oncogenes (Myc, Bcl-2). Correlation between positivity of these factors and clinical outcomes were evaluated using logrank test and cox regression analysis. RESULTS: Among these factors, complete response to HD-MTX was significantly associated with longer progression-free survival (PFS)(P = 0.0012), while Bcl-6 expression as well as histological subtype (non-germinal center B-cell, non-GCB) was closely correlated with shorter PFS. Age (>60) (P = 0.006) and MSH2 expression (P = 0.017) were found to be better predictor for overall survival (OS), but in multivariate analysis, they were no longer significant. Other factors involved in MTX metabolism, DNA repair enzymes, and oncogenes did not affect outcome. CONCLUSIONS: Non-GCB subtype and Bcl-6 expression may be associated with worse outcome in patients with PCNSL treated with HD-MTX, while MTX-metabolism related factors did not influence prognosis. Further investigation is needed to assess Bcl-6 as a potential prognostic factor in PCNSL. SECONDARY CATEGORY: Clinical Neuro-Oncology.

  4. The carpenter fork bed, a new - and older - Black-shale unit at the base of the New Albany shale in central Kentucky: Characterization and significance

    USGS Publications Warehouse

    Barnett, S.F.; Ettensohn, F.R.; Norby, R.D.

    1996-01-01

    Black shales previously interpreted to be Late Devonian cave-fill or slide deposits are shown to be much older Middle Devonian black shales only preserved locally in Middle Devonian grabens and structural lows in central Kentucky. This newly recognized - and older -black-shale unit occurs at the base of the New Albany Shale and is named the Carpenter Fork Bed of the Portwood Member of the New Albany Shale after its only known exposure on Carpenter Fork in Boyle County, central Kentucky; two other occurrences are known from core holes in east-central Kentucky. Based on stratigraphic position and conodont biostratigraphy, the unit is Middle Devonian (Givetian: probably Middle to Upper P. varcus Zone) in age and occurs at a position represented by an unconformity atop the Middle Devonian Boyle Dolostone and its equivalents elsewhere on the outcrop belt. Based on its presence as isolated clasts in the overlying Duffin Bed of the Portwood Member, the former distribution of the unit was probably much more widespread - perhaps occurring throughout western parts of the Rome trough. Carpenter Fork black shales apparently represent an episode of subsidence or sea-level rise coincident with inception of the third tectophase of the Acadian orogeny. Deposition, however, was soon interrupted by reactivation of several fault zones in central Kentucky, perhaps in response to bulge migration accompanying start of the tectophase. As a result, much of central Kentucky was uplifted and tilted, and the Carpenter Fork Bed was largely eroded from the top of the Boyle, except in a few structural lows like the Carpenter Fork graben where a nearly complete record of Middle to early Late Devonian deposition is preserved.

  5. Primary failure of eruption combined with bilateral transmigration of mandibular canines, transposition, torus palatinus, and class III incisor relationship: A rare case report

    PubMed Central

    Elhag, Salma Babiker Idris; Abdulghani, Ashraf Sidig Idris

    2015-01-01

    Eruption disorders are numerous varying from delayed to complete failure of eruption. Primary failure of eruption (PFE) is a rare condition that involves arrested eruption of teeth with the absence of local or general contributory factors. Another rare and clinically challenging phenomenon is canine transmigration which is the intra-osseous movement of impacted canines across the midline. This report presents the first case of combined failure of eruption of multiple teeth with bilateral mandibular canine transmigration, transposition of upper canine and the first premolar, torus palatinus, and class III incisor relationship in a 33-year-old asymptomatic and nonsyndromic female patient.

  6. Ankylosed maxillary incisor with severe root resorption treated with a single-tooth dento-osseous osteotomy, vertical alveolar distraction osteogenesis, and mini-implant anchorage.

    PubMed

    Sen???k, Neslihan Ebru; Koer, Glperi; Kaya, Bulem reyen

    2014-09-01

    Dentoalveolar ankylosis interferes with the vertical growth of the alveolar process, which can lead to an open bite, an unesthetic smile, and occlusal disharmony. This case report presents a new treatment protocol for an ankylosed tooth with severe root resorption using a combined surgical orthodontic management protocol involving a single-tooth dento-osseous osteotomy and vertical alveolar distraction osteogenesis with intraoral elastics and mini-implant anchorage. After distraction and active orthodontic treatment, the patient's anterior open bite was corrected. A Class I dental relationship was achieved, overjet was decreased, and a normal incisor relationship was obtained. PMID:25172260

  7. Primary failure of eruption combined with bilateral transmigration of mandibular canines, transposition, torus palatinus, and class III incisor relationship: A rare case report.

    PubMed

    Elhag, Salma Babiker Idris; Abdulghani, Ashraf Sidig Idris

    2015-01-01

    Eruption disorders are numerous varying from delayed to complete failure of eruption. Primary failure of eruption (PFE) is a rare condition that involves arrested eruption of teeth with the absence of local or general contributory factors. Another rare and clinically challenging phenomenon is canine transmigration which is the intra-osseous movement of impacted canines across the midline. This report presents the first case of combined failure of eruption of multiple teeth with bilateral mandibular canine transmigration, transposition of upper canine and the first premolar, torus palatinus, and class III incisor relationship in a 33-year-old asymptomatic and nonsyndromic female patient. PMID:26929701

  8. The case of diagnostics of invasive pulmonary aspergillosis by in vivo probe-based confocal laser endomicroscopy of central and distal airways

    PubMed Central

    Danilevskaya, Olesya; Averyanov, Alexander; Klimko, Nikolay; Lesnyak, Viktor; Sorokina, Anastasia; Sazonov, Dmitry; Zabozlaev, Fedor

    2014-01-01

    We present a case of 41-year-old patient with invasive pulmonary aspergillosis (IPA) in which probe-based confocal laser endomicroscopy (pCLE) imaging of central and distal airways was first performed in vivo. pCLE imaging showed the signs of complete or partial destruction of elastin network of alveolar wall with fibrillar branching fluorescent structures in the zone with typical IPA changes on HRCT. PMID:25180153

  9. Analysis of bacterial core communities in the central Baltic by comparative RNA–DNA-based fingerprinting provides links to structure–function relationships

    PubMed Central

    Brettar, Ingrid; Christen, Richard; Höfle, Manfred G

    2012-01-01

    Understanding structure–function links of microbial communities is a central theme of microbial ecology since its beginning. To this end, we studied the spatial variability of the bacterioplankton community structure and composition across the central Baltic Sea at four stations, which were up to 450 km apart and at a depth profile representative for the central part (Gotland Deep, 235 m). Bacterial community structure was followed by 16S ribosomal RNA (rRNA)- and 16S rRNA gene-based fingerprints using single-strand conformation polymorphism (SSCP) electrophoresis. Species composition was determined by sequence analysis of SSCP bands. High similarities of the bacterioplankton communities across several hundred kilometers were observed in the surface water using RNA- and DNA-based fingerprints. In these surface communities, the RNA- and DNA-based fingerprints resulted in very different pattern, presumably indicating large difference between the active members of the community as represented by RNA-based fingerprints and the present members represented by the DNA-based fingerprints. This large discrepancy changed gradually over depth, resulting in highly similar RNA- and DNA-based fingerprints in the anoxic part of the water column below 130 m depth. A conceivable mechanism explaining this high similarity could be the reduced oxidative stress in the anoxic zone. The stable communities on the surface and in the anoxic zone indicate the strong influence of the hydrography on the bacterioplankton community structure. Comparative analysis of RNA- and DNA-based community structure provided criteria for the identification of the core community, its key members and their links to biogeochemical functions. PMID:21697960

  10. Discovery of a series of efficient, centrally efficacious BACE1 inhibitors through structure-based drug design.

    PubMed

    Butler, Christopher R; Brodney, Michael A; Beck, Elizabeth M; Barreiro, Gabriela; Nolan, Charles E; Pan, Feng; Vajdos, Felix; Parris, Kevin; Varghese, Alison H; Helal, Christopher J; Lira, Ricardo; Doran, Shawn D; Riddell, David R; Buzon, Leanne M; Dutra, Jason K; Martinez-Alsina, Luis A; Ogilvie, Kevin; Murray, John C; Young, Joseph M; Atchison, Kevin; Robshaw, Ashley; Gonzales, Cathleen; Wang, Jinlong; Zhang, Yong; O'Neill, Brian T

    2015-03-26

    The identification of centrally efficacious ?-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease (AD) has historically been thwarted by an inability to maintain alignment of potency, brain availability, and desired absorption, distribution, metabolism, and excretion (ADME) properties. In this paper, we describe a series of truncated, fused thioamidines that are efficiently selective in garnering BACE1 activity without simultaneously inhibiting the closely related cathepsin D or negatively impacting brain penetration and ADME alignment, as exemplified by 36. Upon oral administration, these inhibitors exhibit robust brain availability and are efficacious in lowering central Amyloid ? (A?) levels in mouse and dog. In addition, chronic treatment in aged PS1/APP mice effects a decrease in the number and size of A?-derived plaques. Most importantly, evaluation of 36 in a 2-week exploratory toxicology study revealed no accumulation of autofluorescent material in retinal pigment epithelium or histology findings in the eye, issues observed with earlier BACE1 inhibitors. PMID:25695670

  11. TrajGraph: A Graph-Based Visual Analytics Approach to Studying Urban Network Centralities Using Taxi Trajectory Data.

    PubMed

    Huang, Xiaoke; Zhao, Ye; Yang, Jing; Zhang, Chong; Ma, Chao; Ye, Xinyue

    2016-01-01

    We propose TrajGraph, a new visual analytics method, for studying urban mobility patterns by integrating graph modeling and visual analysis with taxi trajectory data. A special graph is created to store and manifest real traffic information recorded by taxi trajectories over city streets. It conveys urban transportation dynamics which can be discovered by applying graph analysis algorithms. To support interactive, multiscale visual analytics, a graph partitioning algorithm is applied to create region-level graphs which have smaller size than the original street-level graph. Graph centralities, including Pagerank and betweenness, are computed to characterize the time-varying importance of different urban regions. The centralities are visualized by three coordinated views including a node-link graph view, a map view and a temporal information view. Users can interactively examine the importance of streets to discover and assess city traffic patterns. We have implemented a fully working prototype of this approach and evaluated it using massive taxi trajectories of Shenzhen, China. TrajGraph's capability in revealing the importance of city streets was evaluated by comparing the calculated centralities with the subjective evaluations from a group of drivers in Shenzhen. Feedback from a domain expert was collected. The effectiveness of the visual interface was evaluated through a formal user study. We also present several examples and a case study to demonstrate the usefulness of TrajGraph in urban transportation analysis. PMID:26529696

  12. Circulation of HIV-1 CRF02_AG among MSM Population in Central Italy: A Molecular Epidemiology-Based Study

    PubMed Central

    Giuliani, Massimo; Santoro, Maria M.; Lo Presti, Alessandra; Cella, Eleonora; Scognamiglio, Paola; Lai, Alessia; Latini, Alessandra; Fabeni, Lavinia; Gori, Caterina; Pinnetti, Carmela; Girardi, Enrico; Perno, Carlo F.; Zehender, Gianguglielmo; Ciccozzi, Massimo

    2013-01-01

    Introduction. The evolutionary and demographic history of the circular recombinant form CRF02_AG in a selected retrospective group of HIV-1 infected men who have sex with men (MSM) resident in Central Italy was investigated. Methods. A total of 55 HIV-1 subtype CRF02_AG pol sequences were analyzed using Bayesian methods and a relaxed molecular clock to reconstruct their dated phylogeny and estimate population dynamics. Results. Dated phylogeny indicated that the HIV-1 CRF02_AG strains currently circulating in Central Italy originated in the early 90's. Bayesian phylogenetic analysis revealed the existence of a main HIV-1 CRF02_AG clade, introduced in the area of Rome before 2000 and subsequently differentiated in two different subclades with a different date of introduction (2000 versus 2005). All the sequences within clusters were interspersed, indicating that the MSM analyzed form a close and restricted network where the individuals, also moving within different clinical centers, attend the same places to meet and exchange sex. Conclusions. It was suggested that the HIV-1 CRF02_AG epidemic entered central Italy in the early 1990s, with a similar trend observed in western Europe. PMID:24369538

  13. ecological geological maps: GIS-based evaluation of the Geo-Ecological Quality Index (GEQUI) in Sicily (Central Mediterranean)

    NASA Astrophysics Data System (ADS)

    Nigro, Fabrizio; Arisco, Giuseppe; Perricone, Marcella; Renda, Pietro; Favara, Rocco

    2010-05-01

    The condition of landscapes and the ecological communities within them is strongly related to levels of human activity. As a consequence, determining status and trends in the pattern of human-dominated landscapes can be useful for understanding the overall conditions of geo-ecological resources. Ecological geological maps are recent tools providing useful informations about a-biotic and biotic features worldwide. These maps represents a new generation of geological maps and depict the lithospheric components conditions on surface, where ecological dynamics (functions and properties) and human activities develop. Thus, these maps are too a fundamental political tool to plan the human activities management in relationship to the territorial/environmental patterns of a date region. Different types of ecological geological maps can be develop regarding the: conditions (situations), zoning, prognosis and recommendations. The ecological geological conditions maps reflects the complex of parameters or individual characteristics of lithosphere, which characterized the opportunity of the influence of lithosphere components on the biota (man, fauna, flora, and ecosystem). The ecological geological zoning maps are foundamental basis for prognosis estimation and nature defenses measures. Estimation from the position of comfort and safety of human life and function of ecosystem is given on these maps. The ecological geological prognosis maps reflect the spatial-temporary prognoses of ecological geological conditions changing during the natural dynamic of natural surrounding and the main-during the economic mastering of territory and natural technical systems. Finally, the ecological geological recommendation maps are based on the ecological geological and social-economical informations, aiming the regulation of territory by the regulation of economic activities and the defense of bio- and socio-sphere extents. Each of these maps may also be computed or in analytic or in synthetic way. The first, characterized or estimated, prognosticated one or several indexes of geological ecological conditions. In the second type of maps, the whole complex is reflected, which defined the modern or prognosticable ecological geological situation. Regarding the ecological geological zoning maps, the contemporary state of ecological geological conditions may be evaluated by a range of parameters into classes of conditions and, on the basis of these informations, the estimation from the position of comfort and safety of human life and function of ecosystem is given. Otherwise, the concept of geoecological land evaluation has become established in the study of landscape/environmental plannings in recent years. It requires different thematic data-sets, deriving from the natural-, social- and amenity-environmental resources analysis, that may be translate in environmental (vulnerability/quality) indexes. There have been some attempts to develop integrated indices related to various aspects of the environment within the framework of sustainable development (e.g.: United Nations Commission on Sustainable Development, World Economic Forum, Advisory Board on Indicators of Sustainable Development of the International Institute for Sustainable Development, Living Planet Index established by the World Wide Fund for Nature, etc.). So, the ecological geological maps represent the basic tool for the geoecological land evaluation policies and may be computed in terms of index-maps. On these basis, a GIS application for assessing the ecological geological zoning is presented for Sicily (Central Mediterranean). The Geo-Ecological Quality Index (GEQUI) map was computed by considering a lot of variables. Ten variables (lithology, climate, landslide distribution, erosion rate, soil type, land cover, habitat, groundwater pollution, roads density and buildings density) generated from available data, were used in the model, in which weighting values to each informative layer were assigned. An overlay analysis was carried out, allowing to classify the region into five classes

  14. Organizational centralization in radiology.

    PubMed

    Aas, I H Monrad

    2006-01-01

    Traditionally, hospitals have a radiology department, where images are taken and interpretation occurs. Teleradiology makes it possible to capture images in one location and transmit them elsewhere for interpretation. Organizational centralization of radiology interpretations is therefore of interest. Empirical data have been collected in qualitative interviews of 26 resource persons with substantial experience with picture archiving and communication systems and teleradiology, from 12 departments of radiology in Norway. The response rate was 90%. A total of 21 theoretically possible types of centralization of image interpretation were identified, representing combinations of three categories of geographical centralization, and seven categories of centralization according to function. Various advantages and disadvantages of centralization were identified. Organizational changes may be decisive for the future of teleradiology, but it may be wise to plan for change in small steps, since we know little about how broad future organizational changes based on teleradiology will be, or what will decide how far particular organizations will go. PMID:16438776

  15. The macroscopic appearance and associated histological changes in the enamel organ of hypoplastic lesions of sheep incisor teeth resulting from induced parasitism.

    PubMed

    Suckling, G; Elliott, D C; Thurley, D C

    1986-01-01

    Twenty-one penned female sheep were infected with a high dose of nematodes (200,000 Trichostrongylus vitrinus and 25,000 Ostertagia circumcincta) during first incisor development when aged 7-8 months. Three sheep were infected with 200,000 T. vitrinus only; 10 sheep were untreated. Anorexia, lassitude and severe diarrhoea were seen in 14 of the infected sheep after 21-26 days. Anthelmintic was given to sheep showing undue distress to end the infection and to all remaining sheep on day 33. Animals were killed at 3 stages: during the infection, at intervals during later tooth development, and at the time of eruption of the incisor teeth, 7-8 months after the parasites were given. Hypoplasia of the labial enamel of 15 out of 19 teeth from sheep killed after recovery from the infection was classified according to the extent and depth as pits, grooves or larger areas of missing enamel with ledge-formation cervically. The amount of missing enamel related to the severity of the systemic disturbance which affected the secretory ameloblasts. During the period of active infection, some secretory ameloblasts showed vacuolization or were shorter than in controls; some cells were no longer adjacent to the organic matrix; some continued to function but abnormally and later became separated from the retained organic matrix by connective tissue. Cervically-placed ledges resulted either from the recovery and resumption of activity of some ameloblasts or from differentiation of new secretory cells after the infection ended. PMID:3467666

  16. Congenitally Missing Maxillary Lateral Incisors: Functional and Periodontal Aspects in Patients Treated with Implants or Space Closure and Tooth Re-Contouring

    PubMed Central

    Marchi, Luciana Manzotti De; Pini, Nbia Inocencya Pavesi; Hayacibara, Roberto Massayuki; Silva, Rafael Santos; Pascotto, Renata Corra

    2012-01-01

    To evaluate functional and periodontal aspects in patients with unilateral or bilateral congenitally missing maxillary lateral incisors, treated with either implants or space closure and tooth re-contouring. The sample consisted of 68 volunteers, divided into 3 groups: SCR - space closure and tooth re-contouring with composite resin (n = 26); SOI implants placed in the area of agenesis (n = 20); and CG - control group (n = 22). A modified Helkimo questionnaire and the Research Diagnostic Criteria for Temporomandibular Disorders were used by a single, previously calibrated evaluator to assess signs and symptoms of temporomandibular joint disorder. The periodontal assessment involved the following aspects: plaque index, bleeding upon probing, pocket depth greater than 3 mm, gingival recession, abfraction, periodontal biotype and papilla index. The data were analyzed using Fisher's exact test and the nonparametric Mann-Whitney and Kruskal-Wallis tests (?=.05). No differences in periodontal status were found between treatments. None of the groups were associated with signs and symptoms of temporomandibular joint disorder. Both treatment alternatives for patients with congenitally missing maxillary lateral incisors were satisfactory and achieved functional and periodontal results similar to those of the control group. PMID:23346262

  17. A Peripheral Dentinogenic Ghost Cell Tumor With Immunohistochemical Investigations and a Literature Review-Based Clinicopathological Comparison Between Peripheral and Central Variants.

    PubMed

    Jayasooriya, Primali Rukmal; Mendis, Balapuwaduge Ranjit Rigorbert Nihal; Lombardi, Tommaso

    2015-09-01

    The aim of the study was to present a peripheral dentinogenic ghost cell tumor (DGCT) and to describe clinicopathological differences between peripheral and central variants of the tumor using a selected literature review. The case report is based on a swelling present on the alveolar ridge of a 74-year-old edentulous denture wearer. The lesion was diagnosed as a peripheral DGCT after excluding the presence of a central lesion. Immunohistochemical investigations revealed similar cytokeratin expression pattern, with CK14 and MNF116 positivity in both the tumor and the surrounding surface epithelium. However, in contrast, CK19 expression was restricted to less than 5% of the tumor cells. A clinicopathological comparison was compiled using 30 cases of peripheral DGCTs (including the present lesion) and 16 cases of central DGCTs published over a period of 40 years. Accordingly, peripheral lesions were more often found in elderly denture wearers, in relation to mandibular gingiva and alveolar mucosa. None of the lesions had recurred after excision. In contrast, majority of the central lesions were common in younger individuals and showed a striking male predilection. It occurred equally on both jaws, while approximately 50% of the lesions gave rise to recurrences. In conclusion, similar cytokeratin expression in both the tumor and surface epithelium can be used to support oral surface epithelial origin, while CK14 positivity confirms the odontogenic derivation of the peripheral DGCT described in the report. In contrast to central DGCT, the peripheral DGCT is a distinct lesion with characteristic clinicopathological profile and nonaggressive behavior. PMID:26162397

  18. Estimation of recurrence interval of large earthquakes on the central Longmen Shan fault zone based on seismic moment accumulation/release model.

    PubMed

    Ren, Junjie; Zhang, Shimin

    2013-01-01

    Recurrence interval of large earthquake on an active fault zone is an important parameter in assessing seismic hazard. The 2008 Wenchuan earthquake (Mw 7.9) occurred on the central Longmen Shan fault zone and ruptured the Yingxiu-Beichuan fault (YBF) and the Guanxian-Jiangyou fault (GJF). However, there is a considerable discrepancy among recurrence intervals of large earthquake in preseismic and postseismic estimates based on slip rate and paleoseismologic results. Post-seismic trenches showed that the central Longmen Shan fault zone probably undertakes an event similar to the 2008 quake, suggesting a characteristic earthquake model. In this paper, we use the published seismogenic model of the 2008 earthquake based on Global Positioning System (GPS) and Interferometric Synthetic Aperture Radar (InSAR) data and construct a characteristic seismic moment accumulation/release model to estimate recurrence interval of large earthquakes on the central Longmen Shan fault zone. Our results show that the seismogenic zone accommodates a moment rate of (2.7??0.3)??10??N?m/yr, and a recurrence interval of 3900??400?yrs is necessary for accumulation of strain energy equivalent to the 2008 earthquake. This study provides a preferred interval estimation of large earthquakes for seismic hazard analysis in the Longmen Shan region. PMID:23878524

  19. Estimation of Recurrence Interval of Large Earthquakes on the Central Longmen Shan Fault Zone Based on Seismic Moment Accumulation/Release Model

    PubMed Central

    Zhang, Shimin

    2013-01-01

    Recurrence interval of large earthquake on an active fault zone is an important parameter in assessing seismic hazard. The 2008 Wenchuan earthquake (Mw 7.9) occurred on the central Longmen Shan fault zone and ruptured the Yingxiu-Beichuan fault (YBF) and the Guanxian-Jiangyou fault (GJF). However, there is a considerable discrepancy among recurrence intervals of large earthquake in preseismic and postseismic estimates based on slip rate and paleoseismologic results. Post-seismic trenches showed that the central Longmen Shan fault zone probably undertakes an event similar to the 2008 quake, suggesting a characteristic earthquake model. In this paper, we use the published seismogenic model of the 2008 earthquake based on Global Positioning System (GPS) and Interferometric Synthetic Aperture Radar (InSAR) data and construct a characteristic seismic moment accumulation/release model to estimate recurrence interval of large earthquakes on the central Longmen Shan fault zone. Our results show that the seismogenic zone accommodates a moment rate of (2.7??0.3)??1017?N?m/yr, and a recurrence interval of 3900??400?yrs is necessary for accumulation of strain energy equivalent to the 2008 earthquake. This study provides a preferred interval estimation of large earthquakes for seismic hazard analysis in the Longmen Shan region. PMID:23878524

  20. Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex.

    PubMed

    Kudalkar, Emily M; Scarborough, Emily A; Umbreit, Neil T; Zelter, Alex; Gestaut, Daniel R; Riffle, Michael; Johnson, Richard S; MacCoss, Michael J; Asbury, Charles L; Davis, Trisha N

    2015-10-13

    Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochore-microtubule attachment, but the mechanism remains unclear. Here, we find that the conserved Mis12/MIND (Mtw1, Nsl1, Nnf1, Dsn1) and Ndc80 (Ndc80, Nuf2, Spc24, Spc25) complexes are connected by an extensive network of contacts, each essential for viability in cells, and collectively able to withstand substantial tensile load. Using a single-molecule approach, we demonstrate that an individual MIND complex enhances the microtubule-binding affinity of a single Ndc80 complex by fourfold. MIND itself does not bind microtubules. Instead, MIND binds Ndc80 complex far from the microtubule-binding domain and confers increased microtubule interaction of the complex. In addition, MIND activation is redundant with the effects of a mutation in Ndc80 that might alter its ability to adopt a folded conformation. Together, our results suggest a previously unidentified mechanism for regulating microtubule binding of an outer kinetochore component by a central kinetochore complex. PMID:26430240

  1. Regulation of outer kinetochore Ndc80 complex-based microtubule attachments by the central kinetochore Mis12/MIND complex

    PubMed Central

    Kudalkar, Emily M.; Scarborough, Emily A.; Umbreit, Neil T.; Zelter, Alex; Gestaut, Daniel R.; Riffle, Michael; Johnson, Richard S.; MacCoss, Michael J.; Asbury, Charles L.; Davis, Trisha N.

    2015-01-01

    Multiple protein subcomplexes of the kinetochore cooperate as a cohesive molecular unit that forms load-bearing microtubule attachments that drive mitotic chromosome movements. There is intriguing evidence suggesting that central kinetochore components influence kinetochoremicrotubule attachment, but the mechanism remains unclear. Here, we find that the conserved Mis12/MIND (Mtw1, Nsl1, Nnf1, Dsn1) and Ndc80 (Ndc80, Nuf2, Spc24, Spc25) complexes are connected by an extensive network of contacts, each essential for viability in cells, and collectively able to withstand substantial tensile load. Using a single-molecule approach, we demonstrate that an individual MIND complex enhances the microtubule-binding affinity of a single Ndc80 complex by fourfold. MIND itself does not bind microtubules. Instead, MIND binds Ndc80 complex far from the microtubule-binding domain and confers increased microtubule interaction of the complex. In addition, MIND activation is redundant with the effects of a mutation in Ndc80 that might alter its ability to adopt a folded conformation. Together, our results suggest a previously unidentified mechanism for regulating microtubule binding of an outer kinetochore component by a central kinetochore complex. PMID:26430240

  2. In silico Neuropeptidome of Female Macrobrachium rosenbergii Based on Transcriptome and Peptide Mining of Eyestalk, Central Nervous System and Ovary

    PubMed Central

    Wang, Tianfang; Zhao, Min; Elizur, Abigail; Sretarugsa, Prapee; Cummins, Scott F.; Sobhon, Prasert

    2015-01-01

    Macrobrachium rosenbergii is the most economically important of the cultured freshwater crustacean species, yet there is currently a deficiency in genomic and transcriptomic information for research requirements. In this study, we present an in silico analysis of neuropeptide genes within the female M. rosenbergii eyestalk, central nervous system, and ovary. We could confidently predict 37 preproneuropeptide transcripts, including those that encode bursicons, crustacean cardioactive peptide, crustacean hyperglycemic hormones, eclosion hormone, pigment-dispersing hormones, diuretic hormones, neuropeptide F, neuroparsins, SIFamide, and sulfakinin. These transcripts are most prominent within the eyestalk and central nervous system. Transcript tissue distribution as determined by reverse transcription-polymerase chain reaction revealed the presence of selected neuropeptide genes of interest mainly in the nervous tissues while others were additionally present in the non-nervous tissues. Liquid chromatography-mass spectrometry analysis of eyestalk peptides confirmed the presence of the crustacean hyperglycemic hormone precursor. This data set provides a strong foundation for further studies into the functional roles of neuropeptides in M. rosenbergii, and will be especially helpful for developing methods to improve crustacean aquaculture. PMID:26023789

  3. Dynamics of water mass in the Central Siberia permafrost zone based on gravity survey from the grace satellites

    NASA Astrophysics Data System (ADS)

    Im, S. T.; Kharuk, V. I.

    2015-12-01

    The GRACE gravimetric survey is applied to analyze the equivalent water mass anomalies (EWMAs) in the permafrost zone of Central Siberia. Variations in EWMAs are related to precipitation, air temperature, potential evapotranspiration, and soil composition (drainage conditions). The EWMA dynamics demonstrates two periods. The period of 2003-2008 is characterized by a positive trend. The one of 2008-2012 shows a decrease in the trend with a simultaneous increase by 30-70% of EWMA dispersion in the background of growth (up to 40%) of precipitation variability. The rate of water mass increment demonstrates a positive correlation with the sand and gravel contents in soil ( r = 0.72) and a negative one with clay content ( r =-0.69 to-0.77). For Taimyr Peninsula, there is a deficit of residual water mass (~250 mm for the period of 2012-2013) indicating the deeper thawing of permafrost soils. In the Central Siberian Plateau, the indicator of more intensive permafrost thawing (and that of an increase in active layer thickness) is a considerable trend of water mass increase (2003-2008). The increasing trend of the largest Siberian rivers (Yenisei and Lena) is revealed in the period of 2003-2012.

  4. In silico Neuropeptidome of Female Macrobrachium rosenbergii Based on Transcriptome and Peptide Mining of Eyestalk, Central Nervous System and Ovary.

    PubMed

    Suwansa-Ard, Saowaros; Thongbuakaew, Tipsuda; Wang, Tianfang; Zhao, Min; Elizur, Abigail; Hanna, Peter J; Sretarugsa, Prapee; Cummins, Scott F; Sobhon, Prasert

    2015-01-01

    Macrobrachium rosenbergii is the most economically important of the cultured freshwater crustacean species, yet there is currently a deficiency in genomic and transcriptomic information for research requirements. In this study, we present an in silico analysis of neuropeptide genes within the female M. rosenbergii eyestalk, central nervous system, and ovary. We could confidently predict 37 preproneuropeptide transcripts, including those that encode bursicons, crustacean cardioactive peptide, crustacean hyperglycemic hormones, eclosion hormone, pigment-dispersing hormones, diuretic hormones, neuropeptide F, neuroparsins, SIFamide, and sulfakinin. These transcripts are most prominent within the eyestalk and central nervous system. Transcript tissue distribution as determined by reverse transcription-polymerase chain reaction revealed the presence of selected neuropeptide genes of interest mainly in the nervous tissues while others were additionally present in the non-nervous tissues. Liquid chromatography-mass spectrometry analysis of eyestalk peptides confirmed the presence of the crustacean hyperglycemic hormone precursor. This data set provides a strong foundation for further studies into the functional roles of neuropeptides in M. rosenbergii, and will be especially helpful for developing methods to improve crustacean aquaculture. PMID:26023789

  5. Evolutionary Relationships of the Triatoma matogrossensis Subcomplex, the Endemic Triatoma in Central-Western Brazil, Based on Mitochondrial DNA Sequences

    PubMed Central

    Gardim, Sueli; Rocha, Cludia S.; Almeida, Carlos E.; Takiya, Daniela M.; da Silva, Marco T. A.; Ambrsio, Daniela L.; Cicarelli, Regina M. B.; da Rosa, Joo A.

    2013-01-01

    The phylogenetic relationships among species of Triatoma matogrossensis subcomplex ( T. baratai, T. guazu, T. matogrossensis, T. sordida, T. vandae, and T. williami) was addressed by using fragments of cytochrome oxidase I (COI), 16S rDNA (16S), and cytochrome b (Cytb) through Bayesian and parsimony analyses. We did not recover a monophyletic T. matogrossensis subcomplex, and their members were found clustered in three strongly supported clades, as follows: i) T. jurbergi + T. matogrossensis + T. vandae + T. garciabesi + T. sordida; ii) with T. guasayana as the sister group of clade (i); and iii) T. williami + T. guazu, however not closely related to the clade formed by the previously mentioned species. The other two endemic species from Central-Western Brazil, T. baratai and T. costalimai, were not recovered with strong clade support as related to other members of this subcomplex. Results call for a further revision in the classification of the subcomplexes within the genus Triatoma. PMID:24002487

  6. Ten Years Evidence-based High-Tech Acupuncture–A Short Review of Centrally Measured Effects* (Part II)

    PubMed Central

    2009-01-01

    The assessment of acupuncture-induced effects on brain function is crucial. Ultrasound-assisted brain function monitoring and bioelectrical methods as well as near infrared spectroscopic procedures and functional magnetic resonance investigations form the basis for the latest scientific examination methods for acupuncture research. The laserneedle acupuncture, which was examined scientifically for the first time in Graz, represents a new painless and non-invasive acupuncture method. In this way, individual combinations of acupuncture points can be stimulated simultaneously according to traditional Chinese medicine. In the context of double-blind studies, effects in the brain could be demonstrated in a reproducible manner for the first time. This second part of the short review article summarizes some of the centrally measured effects of acupuncture obtained at the Medical University of Graz within the last 10 years. PMID:18955280

  7. Remote sensing and hydrological measurement based irrigation performance assessments in the upper Amu Darya Delta, Central Asia

    NASA Astrophysics Data System (ADS)

    Conrad, C.; Dech, S. W.; Hafeez, M.; Lamers, J. P. A.; Tischbein, B.

    In the Aral Sea Basin, where the Central Asian countries compete for limited water resources, reliable information on the actual water use for eight million ha of irrigated land are rare. In this study, spatially distributed land use data, seasonal actual evapotranspiration, and reference evapotranspiration derived from multitemporal MODIS data were combined with in situ water flow measurements for irrigation performance assessments in the upper Amu Darya Delta. The functioning of the major irrigation and drainage which supplies an agricultural area of 270,000 ha in the Uzbek province Khorezm was analysed using water balancing and adequacy indicators of irrigation water use. An average relative evapotranspiration of 95% indicated fulfilled water demands and partly over-irrigation, whereas values below 75% disclosed inadequate water supply in distant parts of the irrigation system. On the other hand, immense water withdrawals of approximately 24,000 m3 ha-1 recorded at the system boundaries between April and September 2005 clearly exceeded the field water demands for cotton cultivation. Only 46% of the total irrigation amounts were consumed for crop production at field level. Throughout the vegetation period, approximately 58% of the total available water left the region as drainage water. Monthly observations of the depleted fraction and the drainage ratio highlighted drainage problems and rising groundwater levels at regional scale. In the most distant downstream subsystem, a high risk of groundwater and soil salinity during the main irrigation phase was found. A combination of high conveyance losses, hydraulic problems, direct linkages between irrigation and drainage, and low field application efficiencies were identified as major reasons for underperforming irrigation. The findings underlined the necessity of water saving and of reconsidering water distribution in Khorezm. The remote sensing approach was concluded as a reliable data basis for regular performance assessments for all irrigation systems in Central Asia.

  8. Model-Based Radiation Dose Correction for Yttrium-90 Microsphere Treatment of Liver Tumors With Central Necrosis

    SciTech Connect

    Liu, Ching-Sheng; Lin, Ko-Han; Lee, Rheun-Chuan; Tseng, Hsiou-Shan; Wang, Ling-Wei; Huang, Pin-I; Chao, Liung-Sheau; Chang, Cheng-Yen; Yen, Sang-Hue; Tung, Chuan-Jong; Wang, Syh-Jen; Oliver Wong, Ching-yee

    2011-11-01

    Purpose: The objectives of this study were to model and calculate the absorbed fraction {phi} of energy emitted from yttrium-90 ({sup 90}Y) microsphere treatment of necrotic liver tumors. Methods and Materials: The tumor necrosis model was proposed for the calculation of {phi} over the spherical shell region. Two approaches, the semianalytic method and the probabilistic method, were adopted. In the former method, the range--energy relationship and the sampling of electron paths were applied to calculate the energy deposition within the target region, using the straight-ahead and continuous-slowing-down approximation (CSDA) method. In the latter method, the Monte Carlo PENELOPE code was used to verify results from the first method. Results: The fraction of energy, {phi}, absorbed from {sup 90}Y by 1-cm thickness of tumor shell from microsphere distribution by CSDA with complete beta spectrum was 0.832 {+-} 0.001 and 0.833 {+-} 0.001 for smaller (r{sub T} = 5 cm) and larger (r{sub T} = 10 cm) tumors (where r is the radii of the tumor [T] and necrosis [N]). The fraction absorbed depended mainly on the thickness of the tumor necrosis configuration, rather than on tumor necrosis size. The maximal absorbed fraction {phi} that occurred in tumors without central necrosis for each size of tumor was different: 0.950 {+-} 0.000, and 0.975 {+-} 0.000 for smaller (r{sub T} = 5 cm) and larger (r{sub T} = 10 cm) tumors, respectively (p < 0.0001). Conclusions: The tumor necrosis model was developed for dose calculation of {sup 90}Y microsphere treatment of hepatic tumors with central necrosis. With this model, important information is provided regarding the absorbed fraction applicable to clinical {sup 90}Y microsphere treatment.

  9. On the accuracy of calculation of the mean residence time of drug in the body and its volumes of distribution based on the assumption of central elimination.

    PubMed

    Berezhkovskiy, Leonid M

    2016-06-01

    1. The steady state and terminal volumes of distribution, as well as the mean residence time of drug in the body (Vss, Vβ, and MRT) are the common pharmacokinetic parameters calculated using the drug plasma concentration-time profile (Cp(t)) following intravenous (iv bolus or constant rate infusion) drug administration. 2. These traditional calculations are valid for the linear pharmacokinetic system with central elimination (i.e. elimination rate being proportional to drug concentration in plasma). The assumption of central elimination is not valid in general, so that the accuracy of the traditional calculation of these parameters is uncertain. 3. The comparison of Vss, Vβ, and MRT calculated by the derived exact equations and by the commonly used ones was made considering a physiological model. It turned out that the difference between the exact and simplified calculations does not exceed 2%. 4. Thus the calculations of Vss, Vβ, and MRT, which are based on the assumption of central elimination, may be considered as quite accurate. Consequently it can be used as the standard for comparisons with kinetic and in silico models. PMID:26406808

  10. Glacial-eustatic sea-level fluctuation curve for Carboniferous-Permian boundary strata based on outcrops in the North American Midcontinent and North-Central Texas

    SciTech Connect

    Boardman, D.R. . School of Geology)

    1993-02-01

    Based on lithologic and faunal analysis of uppermost Carboniferous through Lower Permian strata (Wabaunsee through lower Chase groups) exposed from southeastern Nebraska through north-central Oklahoma, a preliminary glacial-eustatic sea-level fluctuation curve is presented herein. In addition to the sea-level curve presented for the Midcontinent region, one for coeval outcropping strata (middle and upper Cisco Group) of the Eastern Shelf of the Midland Basin is also presented based on similar criteria. This sea-level curve is derived from new field studies as well as a refinement of earlier curves presented by Harrison (1973), and Boardman and Malinky (1985). The conclusion on the nature of the Carboniferous-Permian boundary strata cyclothems in the Midcontinent is mirrored by the results of that from North-Central Texas. Each of the primary biostratigraphically-based picks for the Carboniferous-Permian boundary coincide with either intermediate of major cycles in both study areas. Utilization of a glacial-eustatic maximum transgressive event for the Carboniferous-Permian boundary should result in a more correlatable level for intercontinental correlation.

  11. A mathematical model to design a lignocellulosic biofuel supply chain system with a case study based on a region in Central Texas.

    PubMed

    An, Heungjo; Wilhelm, Wilbert E; Searcy, Stephen W

    2011-09-01

    This study formulates a model to maximize the profit of a lignocellulosic biofuel supply chain ranging from feedstock suppliers to biofuel customers. The model deals with a time-staged, multi-commodity, production/distribution system, prescribing facility locations and capacities, technologies, and material flows. A case study based on a region in Central Texas demonstrates application of the proposed model to design the most profitable biofuel supply chain under each of several scenarios. A sensitivity analysis identifies that ethanol (ETOH) price is the most significant factor in the economic viability of a lignocellulosic biofuel supply chain. PMID:21724388

  12. Numerical and experimental study on silicon microresonators based on phononic crystal slabs with reduced central-hole radii

    NASA Astrophysics Data System (ADS)

    Wang, Nan; Hsiao, Fu-Li; Tsai, J. M.; Palaniapan, Moorthi; Kwong, Dim-Lee; Lee, Chengkuo

    2013-06-01

    In this paper, we report the numerical and experimental study on micromechanical resonators which are made by introducing defects on an otherwise perfect two-dimensional (2D) silicon phononic crystal (PnC) slab. The 2D PnC slab is made by etching a square array of cylindrical air holes in a free-standing silicon plate with a thickness of 10 m, while the defects are created by reducing the radii of three rows of air holes at the centre of the 2D PnC slab. Three resonators with different values of reduced radii, i.e., 2 m, 4 m and 6 m, are included in this study. The finite-element-modelling method is used to calculate the band structure of the perfect 2D PnC slab and to analyse the different mode shapes of the structure. The design, numerical modelling, fabrication process, as well as characterization results and discussions of the three PnC resonators are also included. Due to its CMOS-compatibility, aluminium nitride is chosen to be the piezoelectric material of the inter-digital transducers, which are used to generate and detect acoustic waves. Testing is done to characterize the resonant frequency (f), quality factor (Q), as well as insertion loss of each of the three microfabricated PnC resonators and the results are discussed by analysing the simulated transmission spectra, the defected band structures, and the steady-state displacement profiles of the structures at their respective resonant frequencies. The experimental results show that the designed PnC resonators with reduced central-hole radii have higher resonant frequency and higher quality factors as compared to their normal Fabry-Perot counterpart, thanks to the higher-frequency modes supported within the cavity and slow sound effect in the lateral direction introduced by the central holes with reduced radii, respectively. As a result, the achieved (f-Q) product can be as high as 2.96 1011, which is among the highest for silicon resonators operating in air.

  13. Rapid immunocytochemistry based on alternating current electric field using squash smear preparation of central nervous system tumors.

    PubMed

    Moriya, Jun; Tanino, Mishie Ann; Takenami, Tomoko; Endoh, Tomoko; Urushido, Masana; Kato, Yasutaka; Wang, Lei; Kimura, Taichi; Tsuda, Masumi; Nishihara, Hiroshi; Tanaka, Shinya

    2016-01-01

    The role of intraoperative pathological diagnosis for central nervous system (CNS) tumors is crucial for neurosurgery when determining the surgical procedure. Especially, treatment of carmustine (BCNU) wafers requires a conclusive diagnosis of high-grade glioma proven by intraoperative diagnosis. Recently, we demonstrated the usefulness of rapid immunohistochemistry (R-IHC) that facilitates antigen-antibody reaction under alternative current (AC) electric field in the intraoperative diagnosis of CNS tumors; however, a higher proportion of water and lipid in the brain parenchyma sometimes leads to freezing artifacts, resulting in poor quality of frozen sections. On the ot