Sample records for chemical biodynamics division

  1. Chemical Biodynamics Division. Annual report 1979

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1980-08-01

    The Chemical Biodynamics Division of LBL continues to conduct basic research on the dynamics of living cells and on the interaction of radiant energy with organic matter. Many aspects of this basic research are related to problems of environmental and health effects of fossil fuel combustion, solar energy conversion and chemical/ viral carcinogenesis.

  2. Chemical Biodynamics Division: Annual report, October 1, 1985-September 30, 1986

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1986-10-01

    The research in the Laboratory of Chemical Biodynamics is almost entirely fundamental research. The biological research component is strongly dominated by a long term interest in two main themes which make up our Structural Biology Program. The first interest has to do with understanding the molecular dynamics of photosynthesis. The Laboratory's investigators are studying the various components that make up the photosynthetic reaction center complexes in many different organisms. This work not only involves understanding the kinetics of energy transfer and storage in plants, but also includes studies to work out how photosynthetic cells regulate the expression of genes encodingmore » the photosynthetic apparatus. The second biological theme is a series of investigations into the relationship between structure and function in nucleic acids. Our basic mission in this program is to couple our chemical and biophysical expertise to understand how not only the primary structure of nucleic acids, but also higher levels of structure including interactions with proteins and other nucleic acids regulate the functional activity of genes. In the chemical sciences work in the Laboratory, our investigators are increasing our understanding of the fundamental chemistry of electronically excited molecules, a critical dimension of every photosynthetic energy storage process. We are developing approaches not only toward the utilization of sophisticated chemistry to store photon energy, but also to develop systems that can emulate the photosynthetic apparatus in the trapping and transfer of photosynthetic energy.« less

  3. Molecular Biodynamers: Dynamic Covalent Analogues of Biopolymers

    PubMed Central

    2017-01-01

    Conspectus Constitutional dynamic chemistry (CDC) features the use of reversible linkages at both molecular and supramolecular levels, including reversible covalent bonds (dynamic covalent chemistry, DCC) and noncovalent interactions (dynamic noncovalent chemistry, DNCC). Due to its inherent reversibility and stimuli-responsiveness, CDC has been widely utilized as a powerful tool for the screening of bioactive compounds, the exploitation of receptors or substrates driven by molecular recognition, and the fabrication of constitutionally dynamic materials. Implementation of CDC in biopolymer science leads to the generation of constitutionally dynamic analogues of biopolymers, biodynamers, at the molecular level (molecular biodynamers) through DCC or at the supramolecular level (supramolecular biodynamers) via DNCC. Therefore, biodynamers are prepared by reversible covalent polymerization or noncovalent polyassociation of biorelevant monomers. In particular, molecular biodynamers, biodynamers of the covalent type whose monomeric units are connected by reversible covalent bonds, are generated by reversible polymerization of bio-based monomers and can be seen as a combination of biopolymers with DCC. Owing to the reversible covalent bonds used in DCC, molecular biodynamers can undergo continuous and spontaneous constitutional modifications via incorporation/decorporation and exchange of biorelevant monomers in response to internal or external stimuli. As a result, they behave as adaptive materials with novel properties, such as self-healing, stimuli-responsiveness, and tunable mechanical and optical character. More specifically, molecular biodynamers combine the biorelevant characters (e.g., biocompatibility, biodegradability, biofunctionality) of bioactive monomers with the dynamic features of reversible covalent bonds (e.g., changeable, tunable, controllable, self-healing, and stimuli-responsive capacities), to realize synergistic properties in one system. In addition

  4. Recent advances in biodynamics of human hand-arm system.

    PubMed

    Dong, Ren G; Wu, John Z; Welcome, Daniel E

    2005-07-01

    The biodynamics of human hand-arm system is one of the most important foundations for the measurement, evaluation, and risk assessment of hand-transmitted vibration (HTV) exposure. This paper presents a new conceptual model relating factors influencing cause-effect relationships for HTV exposure, a new study strategy, and a comprehensive review of the recent advances in the biodynamics closely associated with HTV exposure. The review covers the following five aspects: theoretical modeling of biodynamic responses, vibration transmissibility, driving-point biodynamic responses, evaluation of anti-vibration gloves, and applied forces. This review finds that some significant advances in each of these aspects have been achieved in the recent years. Several important issues and problems in the biodynamic measurement have been identified and resolved, which has significantly helped improve the reliability and accuracy of the experimental data. The results reported in recent years suggest that, from the point of view of biodynamics, the frequency weighting specified in ISO 5349-1 (2001) overestimates the low frequency effect but underestimates the high frequency effect on the fingers and hand. The major problems, issues, and topics for further studies are also outlined in this paper. It is anticipated that the further studies of the biodynamics of the system will eventually lead to establishment of a robust vibration exposure theory. Although this review focuses on the biodynamics of the hand-arm system, the fundamental concepts and some methodologies reviewed in this paper may also be applicable for the study of whole-body vibration exposure.

  5. Problems in modeling man machine control behavior in biodynamic environments

    NASA Technical Reports Server (NTRS)

    Jex, H. R.

    1972-01-01

    Reviewed are some current problems in modeling man-machine control behavior in a biodynamic environment. It is given in two parts: (1) a review of the models which are appropriate for manual control behavior and the added elements necessary to deal with biodynamic interfaces; and (2) a review of some biodynamic interface pilot/vehicle problems which have occurred, been solved, or need to be solved.

  6. Growth, Yield and Fruit Quality of Grapevines under Organic and Biodynamic Management

    PubMed Central

    Döring, Johanna; Frisch, Matthias; Tittmann, Susanne; Stoll, Manfred; Kauer, Randolf

    2015-01-01

    The main objective of this study was to determine growth, yield and fruit quality of grapevines under organic and biodynamic management in relation to integrated viticultural practices. Furthermore, the mechanisms for the observed changes in growth, yield and fruit quality were investigated by determining nutrient status, physiological performance of the plants and disease incidence on bunches in three consecutive growing seasons. A field trial (Vitis vinifera L. cv. Riesling) was set up at Hochschule Geisenheim University, Germany. The integrated treatment was managed according to the code of good practice. Organic and biodynamic plots were managed according to Regulation (EC) No 834/2007 and Regulation (EC) No 889/2008 and according to ECOVIN- and Demeter-Standards, respectively. The growth and yield of the grapevines differed strongly among the different management systems, whereas fruit quality was not affected by the management system. The organic and the biodynamic treatments showed significantly lower growth and yield in comparison to the integrated treatment. The physiological performance was significantly lower in the organic and the biodynamic systems, which may account for differences in growth and cluster weight and might therefore induce lower yields of the respective treatments. Soil management and fertilization strategy could be responsible factors for these changes. Yields of the organic and the biodynamic treatments partially decreased due to higher disease incidence of downy mildew. The organic and the biodynamic plant protection strategies that exclude the use of synthetic fungicides are likely to induce higher disease incidence and might partially account for differences in the nutrient status of vines under organic and biodynamic management. Use of the biodynamic preparations had little influence on vine growth and yield. Due to the investigation of important parameters that induce changes especially in growth and yield of grapevines under

  7. Expectation or Sensorial Reality? An Empirical Investigation of the Biodynamic Calendar for Wine Drinkers

    PubMed Central

    Parr, Wendy V.; Valentin, Dominique; Reedman, Phil; Grose, Claire; Green, James A.

    2017-01-01

    The study’s aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors. Wine descriptors spanned a range of varietal-relevant aroma, taste, and mouthfeel characteristics, and were selected with the aim of elucidating both qualitative and quantitative aspects of each wine’s perceived aromatic, taste, and structural aspects including overall wine quality and liking. A post-experimental questionnaire was completed by each participant to determine their degree of knowledge about the purpose of the study, and their awareness of the existence of the biodynamic wine drinkers’ calendar. Basic wine physico-chemical parameters were determined for the wines tasted on each of a Fruit day and a Root day. Results demonstrated that the wines were judged differentially on all attributes measured although type of day as determined by the biodynamic calendar for wine drinkers did not influence systematically any of the wine characteristics evaluated. The findings highlight the importance of testing experimentally practices that are based on anecdotal evidence but that lend themselves to empirical investigation. PMID:28046047

  8. Expectation or Sensorial Reality? An Empirical Investigation of the Biodynamic Calendar for Wine Drinkers.

    PubMed

    Parr, Wendy V; Valentin, Dominique; Reedman, Phil; Grose, Claire; Green, James A

    2017-01-01

    The study's aim was to investigate a central tenet of biodynamic philosophy as applied to wine tasting, namely that wines taste different in systematic ways on days determined by the lunar cycle. Nineteen New Zealand wine professionals tasted blind 12 Pinot noir wines at times determined within the biodynamic calendar for wine drinkers as being favourable (Fruit day) and unfavourable (Root day) for wine tasting. Tasters rated each wine four times, twice on a Fruit day and twice on a Root day, using 20 experimenter-provided descriptors. Wine descriptors spanned a range of varietal-relevant aroma, taste, and mouthfeel characteristics, and were selected with the aim of elucidating both qualitative and quantitative aspects of each wine's perceived aromatic, taste, and structural aspects including overall wine quality and liking. A post-experimental questionnaire was completed by each participant to determine their degree of knowledge about the purpose of the study, and their awareness of the existence of the biodynamic wine drinkers' calendar. Basic wine physico-chemical parameters were determined for the wines tasted on each of a Fruit day and a Root day. Results demonstrated that the wines were judged differentially on all attributes measured although type of day as determined by the biodynamic calendar for wine drinkers did not influence systematically any of the wine characteristics evaluated. The findings highlight the importance of testing experimentally practices that are based on anecdotal evidence but that lend themselves to empirical investigation.

  9. Chemical and sensory characterisation of Sangiovese red wines: comparison between biodynamic and organic management.

    PubMed

    Parpinello, Giuseppina Paola; Rombolà, Adamo Domenico; Simoni, Marco; Versari, Andrea

    2015-01-15

    The effects of biodynamic production practices on composition and sensory attributes of Sangiovese wines were examined for 2 years (2009 and 2010) in a vineyard that was converted from organic (ORG) to biodynamic (BDN) viticulture. During the first year (2009), the BDN wines were characterised by low alcohol strength, colour intensity, total polyphenols, monomeric anthocyanins and catechin. Conversely, the second year BDN wines differed from the organic wines in terms of total polyphenols and phenolic compounds, including polymeric pigments, co-pigmentation, tannins and iron-reactive polyphenols. The effect of management practices, harvest and their interaction was analysed for each compound. Positive interaction was observed for total acidity, volatile acidity, cyanidin-3-glucoside, protocatechuic acid, (+)-catechin, quercetin and trans-resveratrol. ORG wine initially showed a more complex aroma profile; however, the differences were almost indistinguishable during the second year. Trained panellists highlighted differences in colour intensity between ORG and BDN wines although no preference was found by consumers. The concentrations of ochratoxin A and biogenic amines were far below the health-hazardous threshold. Copyright © 2014 Elsevier Ltd. All rights reserved.

  10. Chemical Engineering Division Activities

    ERIC Educational Resources Information Center

    Chemical Engineering Education, 1978

    1978-01-01

    The 1978 ASEE Chemical Engineering Division Lecturer was Theodore Vermeulen of the University of California at Berkeley. Other chemical engineers who received awards or special recognition at a recent ASEE annual conference are mentioned. (BB)

  11. Biodynamic Doppler imaging of subcellular motion inside 3D living tissue culture and biopsies (Conference Presentation)

    NASA Astrophysics Data System (ADS)

    Nolte, David D.

    2016-03-01

    Biodynamic imaging is an emerging 3D optical imaging technology that probes up to 1 mm deep inside three-dimensional living tissue using short-coherence dynamic light scattering to measure the intracellular motions of cells inside their natural microenvironments. Biodynamic imaging is label-free and non-invasive. The information content of biodynamic imaging is captured through tissue dynamics spectroscopy that displays the changes in the Doppler signatures from intracellular constituents in response to applied compounds. The affected dynamic intracellular mechanisms include organelle transport, membrane undulations, cytoskeletal restructuring, strain at cellular adhesions, cytokinesis, mitosis, exo- and endo-cytosis among others. The development of 3D high-content assays such as biodynamic profiling can become a critical new tool for assessing efficacy of drugs and the suitability of specific types of tissue growth for drug discovery and development. The use of biodynamic profiling to predict clinical outcome of living biopsies to cancer therapeutics can be developed into a phenotypic companion diagnostic, as well as a new tool for therapy selection in personalized medicine. This invited talk will present an overview of the optical, physical and physiological processes involved in biodynamic imaging. Several different biodynamic imaging modalities include motility contrast imaging (MCI), tissue-dynamics spectroscopy (TDS) and tissue-dynamics imaging (TDI). A wide range of potential applications will be described that include process monitoring for 3D tissue culture, drug discovery and development, cancer therapy selection, embryo assessment for in-vitro fertilization and artificial reproductive technologies, among others.

  12. (1)H NMR foodomics reveals that the biodynamic and the organic cultivation managements produce different grape berries (Vitis vinifera L. cv. Sangiovese).

    PubMed

    Picone, Gianfranco; Trimigno, Alessia; Tessarin, Paola; Donnini, Silvia; Rombolà, Adamo Domenico; Capozzi, Francesco

    2016-12-15

    The increasing demand for natural foods and beverages, i.e. prepared by excluding synthetic chemicals along the whole production chain, has boosted the adoption of organic and biodynamic cultivation methods which are based on protocols avoiding use of synthetic pesticides. This trend is striking in viticulture, since wine production is largely shaped by the varying drinking attitudes of environment-friendly consumers. Using (1)H NMR, the compositions of grape berries, collected at harvest in 2009 and 2011, in experimental plots cultivated either with biodynamic or organic methods, were compared. Although the analysis provides a comprehensive metabolic profile of berries, the resulting distinctive pattern consists of a few molecules. Lower content of sugars, coumaric and caffeic acids, as well as higher amount of γ-aminobutyric acid (GABA) were observed in biodynamic grapes. The (1)H NMR foodomics approach evidenced a diverse fruit metabolome that could be associated to a different physiological response of plants to the agronomic environment. Copyright © 2016 Elsevier Ltd. All rights reserved.

  13. Chemical composition and antifungal activity of plant extracts traditionally used in organic and biodynamic farming.

    PubMed

    Andreu, Vanessa; Levert, Annabel; Amiot, Anaïs; Cousin, Anaïs; Aveline, Nicolas; Bertrand, Cédric

    2018-03-07

    Five plant extracts traditionally used in organic and biodynamic farming for pest control and antifungal (downy mildew) disease management were selected after a farmer survey and analyzed for their chemical composition in LC-PDA-MS-MS and using adapted analytical method from food chemistry for determination of class of component (e.g., protein, sugar, lipids…). Their antifungal activity against Penicillium expansum, Botrytis cinerea, Botrytis allii, brown rot causing agents (Monilinia laxa and Monilinia fructigena), and grape downy mildew (Plasmopara viticola) was examined in vitro. White willow (Salix alba) and absinthe (Artemisia absinthium) ethanolic extracts were found to be the most effective in particular against Plasmopara viticola, with a total inhibition of spores germination when applied at 1000 mg/L. These extracts also showed a relatively low toxicity during preliminary ecotoxicological assays on Daphnia pulex. Extract from the bark of white willow contained some flavonoids, especially flavanones (eriodyctiol and derivates) and flavanols (catechins and derivates), as major compounds, whereas absinthe extract was rich in O-methylated flavanols and hydroxycinnamic acids. Thujone content in this extract was also determined by external calibration in GC-MS analysis, and its value was 0.004% dry extract.

  14. A potential non-invasive approach to evaluating blastocyst quality using biodynamic imaging

    NASA Astrophysics Data System (ADS)

    Li, Zhe; Ehmke, Natalie; Machaty, Zoltan; Nolte, David

    2018-02-01

    Biodynamic imaging (BDI) is capable of capturing the intracellular dynamics of blastocysts within a relatively short time. Spectroscopic signatures of embryos in the 0.01 Hz - 1 Hz range display responses to external factors before morphology changes take place. Viability evaluation is consistent with results from other non-invasive methods. Biodynamic imaging is a potential tool for selecting high quality embryos in clinical IVF practices.

  15. Multi-stimuli-responsive biohybrid nanoparticles with cross-linked albumin coronae self-assembled by a polymer-protein biodynamer.

    PubMed

    Wang, Lin; Liu, Li; Dong, Bingyang; Zhao, Hanying; Zhang, Mingming; Chen, Wenjuan; Hong, Yanhang

    2017-05-01

    . The prepared biodynamer can offer a potential platform for intracellular protein delivery. The multi-stimuli-responsive biohybrid nanoparticles containing disulfide functionalities are constructed by cross-linking albumin coronae of the biodynamer micelles. With the combination of a thermoresponsive polymer, protein and reversible covalent bonds, the biohybrid nanoparticles are endowed with highly biocompatible, environmentally responsive and adaptive features. These nanoparticles present the ability to undergo changes in their constitution, hydrodynamic size and nanostructure in response to physical, chemical and biological stimuli, which make them interesting candidates as vehicles for drug delivery application and a biomimetic platform to investigate the biological process in nature. Copyright © 2017 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.

  16. Biodynamic imaging of therapeutic efficacy for canine B-cell lymphoma: preclinical trial results

    NASA Astrophysics Data System (ADS)

    Choi, H.; Turek, J.; Li, Z.; Childress, M.; Nolte, D.

    2018-02-01

    Biodynamic imaging uses coherence-gated dynamic light scattering to create three dimensional maps of intracellular dynamics in living tissue biopsies. The technique is sensitive to changes in intracellular dynamics dependent on the mechanism of action (MoA) of therapeutics applied in vitro to the living samples. A preclinical trial in the assessment of chemotherapeutic response of dogs with B-cell lymphoma to the doxorubicin-based therapy CHOP has been completed using biodynamic imaging. The trial enrolled 19 canine patients presenting with non-Hodgkin's B-cell lymphoma. Biopsies were acquired through surgery or through needle cores. The time-varying power spectrum of scattered light after drugs are applied ex vivo to the biopsies represent biodynamic biomarkers that are used in machine learning algorithms to predict the patient clinical outcome. Two distinct phenotypes emerged from the analysis that correlate with patient drug resistance or sensitivity. Cross validation of the algorithms perform with an accuracy of 90% in the prediction of dogs that will respond to treatment. Biodynamic imaging has the potential to help select chemotherapy for personalized cancer care.

  17. A biodynamic feedthrough model based on neuromuscular principles.

    PubMed

    Venrooij, Joost; Abbink, David A; Mulder, Mark; van Paassen, Marinus M; Mulder, Max; van der Helm, Frans C T; Bulthoff, Heinrich H

    2014-07-01

    A biodynamic feedthrough (BDFT) model is proposed that describes how vehicle accelerations feed through the human body, causing involuntary limb motions and so involuntary control inputs. BDFT dynamics strongly depend on limb dynamics, which can vary between persons (between-subject variability), but also within one person over time, e.g., due to the control task performed (within-subject variability). The proposed BDFT model is based on physical neuromuscular principles and is derived from an established admittance model-describing limb dynamics-which was extended to include control device dynamics and account for acceleration effects. The resulting BDFT model serves primarily the purpose of increasing the understanding of the relationship between neuromuscular admittance and biodynamic feedthrough. An added advantage of the proposed model is that its parameters can be estimated using a two-stage approach, making the parameter estimation more robust, as the procedure is largely based on the well documented procedure required for the admittance model. To estimate the parameter values of the BDFT model, data are used from an experiment in which both neuromuscular admittance and biodynamic feedthrough are measured. The quality of the BDFT model is evaluated in the frequency and time domain. Results provide strong evidence that the BDFT model and the proposed method of parameter estimation put forward in this paper allows for accurate BDFT modeling across different subjects (accounting for between-subject variability) and across control tasks (accounting for within-subject variability).

  18. Hand-transmitted vibration and biodynamic response of the human hand-arm: a critical review.

    PubMed

    Dong, R G; Rakheja, S; Schopper, A W; Han, B; Smutz, W P

    2001-01-01

    Hand-arm vibration syndrome (HAVS) has been associated with prolonged exposure to vibration transmitted to the human hand-arm system from hand-held power tools, vibrating machines, or hand-held vibrating workpieces. The biodynamic response of the human hand and arm to hand transmitted vibration (HTV) forms an essential basis for effective evaluations of exposures, vibration-attenuation mechanisms, and potential injury mechanisms. The biodynamic response to HTV and its relationship to HAVS are critically reviewed and discussed to highlight the advances and the need for further research. In view of its strong dependence on the nature of HTV and the lack of general agreement on the characteristics of HTV, the reported studies are first reviewed to enhance an understanding of HTV and related issues. The characteristics of HTV and relevant unresolved issues are discussed on the basis of measured data, proposed standards, and measurement methods, while the need for further developments in measurement systems is emphasized. The studies on biodynamic response and their findings are grouped into four categories based on the methodology used and the objective. These include studies on (1) through-the-hand-arm response, expressed in terms of vibration transmissibility; (2) to-the-hand response, expressed in terms of the force-motion relationship of the hand-arm system; (3) to-the-hand biodynamic response function, expressed in terms of vibration energy absorption; and (4) computer modeling of the biodynamic response characteristics.

  19. Soil response to biodynamic farming practices in estevia -Stevia Rebaudiana- (Extremadura, Spain)

    NASA Astrophysics Data System (ADS)

    Labrador, Juana; Colmenares, Ricardo; Sánchez, Eduardo; Creus, Juan; García, Nieves; Blázquez, Jaime; Moreno, Marta M.

    2014-05-01

    The first results of the evolution of an organic-biodynamic cultivation of stevia (Stevia rebaudiana) in Extremadura (Spain) are shown here. The organic-biodynamic approach permits experimentally for a more holistic view of the crop development process what means the understanding and quantification of its evolution at different scales. The research methodology applied includes not only quantitative individual parameters of the crop development but also global parameters which make a contribution of very relevant information concerning unbalances between growth and differentiation processes, as well as other aspects linked to the product intrinsic quality. The crop cultivation has been done over a plot of 2.5 has, on acid soils (pH 5.18) and very poor organic matter content (0.5 %). On this first year of cultivation two cuts were given to the plant with an average total yield of 4,500 kg/ha without any supply of solid organic matter, only with the application of the biodynamic preparations. So far results regarding soil improvement and crop productivity, taking into consideration the practices used, let us introduce this pioneer crop in Extremadura, not only as an alternative crop to the current tobacco crop in this area, but also as a development resource for the rural environment of this region. Key words: Agroecology, Organic Biodynamic Agriculture, Stevia Rebaudiana

  20. Biodynamic profiling of three-dimensional tissue growth techniques

    NASA Astrophysics Data System (ADS)

    Sun, Hao; Merrill, Dan; Turek, John; Nolte, David

    2016-03-01

    Three-dimensional tissue culture presents a more biologically relevant environment in which to perform drug development than conventional two-dimensional cell culture. However, obtaining high-content information from inside three dimensional tissue has presented an obstacle to rapid adoption of 3D tissue culture for pharmaceutical applications. Biodynamic imaging is a high-content three-dimensional optical imaging technology based on low-coherence interferometry and digital holography that uses intracellular dynamics as high-content image contrast. In this paper, we use biodynamic imaging to compare pharmaceutical responses to Taxol of three-dimensional multicellular spheroids grown by three different growth techniques: rotating bioreactor, hanging-drop and plate-grown spheroids. The three growth techniques have systematic variations among tissue cohesiveness and intracellular activity and consequently display different pharmacodynamics under identical drug dose conditions. The in vitro tissue cultures are also compared to ex vivo living biopsies. These results demonstrate that three-dimensional tissue cultures are not equivalent, and that drug-response studies must take into account the growth method.

  1. American Chemical Society division of fuel chemistry Henry H. Storch award.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Chemistry

    American Chemical Society Division of Fuel Chemistry Henry H. Storch Award ... The purpose of the Henry H. Storch Award is to recognize distinguished contributions worldwide to fundamental or engineering research on the chemistry and utilization of all hydrocarbon fuels, with the exception of petroleum. ... The award was established in 1964 by the American Chemical Society Division of Fuel Chemistry and administered by the Division until 1985.

  2. Biodynamic digital holography of chemoresistance in a pre-clinical trial of canine B-cell lymphoma.

    PubMed

    Choi, Honggu; Li, Zhe; Sun, Hao; Merrill, Dan; Turek, John; Childress, Michael; Nolte, David

    2018-05-01

    Biodynamic digital holography was used to obtain phenotypic profiles of canine non-Hodgkin B-cell lymphoma biopsies treated with standard-of-care chemotherapy. Biodynamic signatures from the living 3D tissues were extracted using fluctuation spectroscopy from intracellular Doppler light scattering in response to the molecular mechanisms of action of therapeutic drugs that modify a range of internal cellular motions. The standard-of-care to treat B-cell lymphoma in both humans and dogs is a combination CHOP therapy that consists of doxorubicin, prednisolone, cyclophosphamide and vincristine. The proportion of dogs experiencing durable cancer remission following CHOP chemotherapy was 68%, with 13 out of 19 dogs responding favorably to therapy and 6 dogs failing to have progression-free survival times greater than 100 days. Biodynamic signatures were found that correlate with inferior survival times, and biomarker selection was optimized to identify specific Doppler signatures related to chemoresistance. A machine learning classifier was constructed based on feature vector correlations and linear separability in high-dimensional feature space. Hold-out validation predicted patient response to therapy with 84% accuracy. These results point to the potential for biodynamic profiling to contribute to personalized medicine by aiding the selection of chemotherapy for cancer patients.

  3. Frequency weightings based on biodynamics of fingers-hand-arm system.

    PubMed

    Dong, Ren G; Welcome, Daniel E; Wu, John Z

    2005-07-01

    The frequency weighting for assessing hand-transmitted vibration exposure is critical to obtaining a true dose-response relationship. Any valid weighting must have a solid theoretical foundation. The objectives of this study are to examine the biodynamic foundation for assessing the vibration exposure and to develop a set of biodynamic methods to formulate the frequency weightings for different anatomical locations of the fingers-hand-arm system. The vibration transmissibility measured on the fingers, hand, wrist, elbow, shoulder, and head was used to define the transmitted acceleration-based (TAB) frequency weighting. The apparent masses measured at the fingers and the palm of the hand were used to construct the biodynamic force-based (BFB) weightings. These weightings were compared with the ISO weighting specified in ISO 5349-1 (2001). The results of this study suggest that the frequency weightings for the vibration-induced problems at different anatomical locations of the hand-arm system can be basically divided into three groups: (a) the weighting for the fingers and hand, (b) the weighting for the wrist, elbow, and shoulder, and (c) the weighting for the head. The ISO weighting is highly correlated with the weighting for the second group but not with the first and third groups. The TAB and BFB finger weightings are quite different at frequencies lower than 100 Hz, but they show similar trends at higher frequencies. Both TAB and BFB finger weightings at frequencies higher than 20 Hz are greater than the ISO weighting.

  4. Biodynamics of deformable human body motion

    NASA Technical Reports Server (NTRS)

    Strauss, A. M.; Huston, R. L.

    1976-01-01

    The objective is to construct a framework wherein the various models of human biomaterials fit in order to describe the biodynamic response of the human body. The behavior of the human body in various situations, from low frequency, low amplitude vibrations to impact loadings in automobile and aircraft crashes, is very complicated with respect to all aspects of the problem: materials, geometry and dynamics. The materials problem is the primary concern, but the materials problem is intimately connected with geometry and dynamics.

  5. A method to quantify hand-transmitted vibration exposure based on the biodynamic stress concept.

    PubMed

    Dong, R G; Welcome, D E; Wu, J Z

    2007-11-01

    This study generally hypothesized that the vibration-induced biodynamic stress and number of its cycles in a substructure of the hand-arm system play an important role in the development of vibration-induced disorders in the substructure. As the first step to test this hypothesis, the specific aims of this study were to develop a practical method to quantify the biodynamic stress-cycle measure, to compare it with ISO-weighted and unweighted accelerations, and to assess its potential for applications. A mechanical-equivalent model of the system was established using reported experimental data. The model was used to estimate the average stresses in the fingers and palm. The frequency weightings of the stresses in these substructures were derived using the proposed stress-cycle measure. This study found the frequency dependence of the average stress distributed in the fingers is different from that in the palm. Therefore, this study predicted that the frequency dependencies of finger disorders could also be different from those of the disorders in the palm, wrist, and arms. If vibration-induced white finger (VWF) is correlated better with unweighted acceleration than with ISO-weighted acceleration, the biodynamic stress distributed in the fingers is likely to play a more important role in the development of VWF than is th e biodynamic stressdistributed in the other substructures of the hand-arm system. The results of this study also suggest that the ISO weighting underestimates the high-frequency effect on the finger disorder development but it may provide a reasonable risk assessment of the disorders in the wrist and arm.

  6. Why is metal bioaccumulation so variable? Biodynamics as a unifying concept

    USGS Publications Warehouse

    Luoma, Samuel N.; Rainbow, Philip S.

    2005-01-01

    Ecological risks from metal contaminants are difficult to document because responses differ among species, threats differ among metals, and environmental influences are complex. Unifying concepts are needed to better tie together such complexities. Here we suggest that a biologically based conceptualization, the biodynamic model, provides the necessary unification for a key aspect in risk:  metal bioaccumulation (internal exposure). The model is mechanistically based, but empirically considers geochemical influences, biological differences, and differences among metals. Forecasts from the model agree closely with observations from nature, validating its basic assumptions. The biodynamic metal bioaccumulation model combines targeted, high-quality geochemical analyses from a site of interest with parametrization of key physiological constants for a species from that site. The physiological parameters include metal influx rates from water, influx rates from food, rate constants of loss, and growth rates (when high). We compiled results from 15 publications that forecast species-specific bioaccumulation, and compare the forecasts to bioaccumulation data from the field. These data consider concentrations that cover 7 orders of magnitude. They include 7 metals and 14 species of animals from 3 phyla and 11 marine, estuarine, and freshwater environments. The coefficient of determination (R2) between forecasts and independently observed bioaccumulation from the field was 0.98. Most forecasts agreed with observations within 2-fold. The agreement suggests that the basic assumptions of the biodynamic model are tenable. A unified explanation of metal bioaccumulation sets the stage for a realistic understanding of toxicity and ecological effects of metals in nature.

  7. Naval Biodynamics Laboratory: 1989 and 1990 Command History

    DTIC Science & Technology

    1991-07-01

    T. G., "Naval Biodynamics Laboratory: Human Factors Research Capabilities and Programs." Presented at the Canal de Experiencias Hidrodinamicas de El...1990. Call, D. W., attended meetings at the Canal de Experiencias Hidrodinamicas de El Padro, Madrid, Spain, 24-26 April 1990. Call, D. W., attended the...LABORATORY Dobie, T. G., attended meetings at the Canal de Experiencias Hidrodinamicas de El Padro, Madrid, Spain, 24-26 April 1990. Dobie, T. G., attended

  8. 75 FR 9437 - Wacker Chemical Corporation Wacker Polymers Division a Subsidiary of Wacker Chemie AG Including...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-02

    ... Chemical Corporation Wacker Polymers Division a Subsidiary of Wacker Chemie AG Including On-Site Leased.... and Yoh Managed Staffing South Brunswick, NJ; Wacker Chemical Corporation Wacker Polymers Division a... of Wacker Chemical Corporation, Wacker Polymers Division, a subsidiary of Wacker Chemie AG, including...

  9. SU-E-J-31: Biodynamic Imaging of Cancer Tissue and Response to Chemotherapy

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Nolte, D; Turek, J; Childress, M

    2014-06-01

    Purpose: To measure intracellular motions inside three-dimensional living cancer tissue samples to establish a novel set of biodynamic biomarkers that assess tissue proliferative activity and sensitivity or resistance to chemotherapy. Methods: Biodynamic imaging (BDI) uses digital holography with low-coherence low-intensity light illumination to construct 3D holograms from depths up to a millimeter deep inside cancer tissue models that include multicellular tumor spheroids and ex vivo cancer biopsies from canine non-Hodgkins lymphoma and epithelial ovarian cancer (EOC) mouse explants. Intracellular motions modulate the holographic intensity with frequencies related to the Doppler effect caused by the motions of a wide variety ofmore » intracellular components. These motions are affected by applied therapeutic agents, and BDI produces unique fingerprints of the action of specific drugs on the motions in specific cell types. In this study, chemotherapeutic agents (doxorubicin for canine lymphoma and oxoplatin for ovarian) are applied to the living tissue models and monitored over 10 hours by BDI. Results: Multicellular spheroids and patient biopsies are categorized as either sensitive or insensitive to applied therapeutics depending on the intracellular Doppler signatures of chemotherapy response. For both lymphoma and EOC there is strong specificity to the two types of sensitivities, with sensitive cell lines and biopsies exhibiting a global cessation of proliferation and strong suppression of metabolic activity, while insensitive cell lines and biopsies show moderate activation of Doppler frequencies associated with membrane processes and possible membrane trafficking. Conclusion: This work supports the hypothesis that biodynamic biomarkers from three-dimensional living tumor tissue, that includes tissue heterogeneity and measured within 24 hours of surgery, is predictive of near-term patient response to therapy. Future work will correlate biodynamic biomarkers

  10. 77 FR 13352 - Exxonmobil Chemical Company Films Business Division Including on-Site Leased Workers From...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-06

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-74,325] Exxonmobil Chemical..., applicable to ExxonMobil Chemical Company, Films Business Division, including on-site leased workers from... Chemical Company, Films Business Division. The Department has determined that these workers were...

  11. A framework for biodynamic feedthrough analysis--part I: theoretical foundations.

    PubMed

    Venrooij, Joost; van Paassen, Marinus M; Mulder, Mark; Abbink, David A; Mulder, Max; van der Helm, Frans C T; Bulthoff, Heinrich H

    2014-09-01

    Biodynamic feedthrough (BDFT) is a complex phenomenon, which has been studied for several decades. However, there is little consensus on how to approach the BDFT problem in terms of definitions, nomenclature, and mathematical descriptions. In this paper, a framework for biodynamic feedthrough analysis is presented. The goal of this framework is two-fold. First, it provides some common ground between the seemingly large range of different approaches existing in the BDFT literature. Second, the framework itself allows for gaining new insights into BDFT phenomena. It will be shown how relevant signals can be obtained from measurement, how different BDFT dynamics can be derived from them, and how these different dynamics are related. Using the framework, BDFT can be dissected into several dynamical relationships, each relevant in understanding BDFT phenomena in more detail. The presentation of the BDFT framework is divided into two parts. This paper, Part I, addresses the theoretical foundations of the framework. Part II, which is also published in this issue, addresses the validation of the framework. The work is presented in two separate papers to allow for a detailed discussion of both the framework's theoretical background and its validation.

  12. Using biodynamic models to reconcile differences between laboratory toxicity tests and field biomonitoring with aquatic insects

    USGS Publications Warehouse

    Buchwalter, D.B.; Cain, D.J.; Clements, W.H.; Luoma, S.N.

    2007-01-01

    Aquatic insects often dominate lotic ecosystems, yet these organisms are under-represented in trace metal toxicity databases. Furthermore, toxicity data for aquatic insects do not appear to reflect their actual sensitivities to metals in nature, because the concentrations required to elicit toxicity in the laboratory are considerably higher than those found to impact insect communities in the field. New approaches are therefore needed to better understand how and why insects are differentially susceptible to metal exposures. Biodynamic modeling is a powerful tool for understanding interspecific differences in trace metal bioaccumulation. Because bioaccumulation alone does not necessarily correlate with toxicity, we combined biokinetic parameters associated with dissolved cadmium exposures with studies of the subcellular compartmentalization of accumulated Cd. This combination of physiological traits allowed us to make predictions of susceptibility differences to dissolved Cd in three aquatic insect taxa: Ephemerella excrucians, Rhithrogena morrisoni, and Rhyacophila sp. We compared these predictions with long-term field monitoring data and toxicity tests with closely related taxa: Ephemerella infrequens, Rhithrogena hageni, and Rhyacophila brunea. Kinetic parameters allowed us to estimate steady-state concentrations, the time required to reach steady state, and the concentrations of Cd projected to be in potentially toxic compartments for different species. Species-specific physiological traits identified using biodynamic models provided a means for better understanding why toxicity assays with insects have failed to provide meaningful estimates for metal concentrations that would be expected to be protective in nature. ?? 2007 American Chemical Society.

  13. Suppression of Biodynamic Interference by Adaptive Filtering

    NASA Technical Reports Server (NTRS)

    Velger, M.; Merhav, S. J.; Grunwald, A. J.

    1984-01-01

    Preliminary experimental results obtained in moving base simulator tests are presented. Both for pursuit and compensatory tracking tasks, a strong deterioration in tracking performance due to biodynamic interference is found. The use of adaptive filtering is shown to substantially alleviate these effects, resulting in a markedly improved tracking performance and reduction in task difficulty. The effect of simulator motion and of adaptive filtering on human operator describing functions is investigated. Adaptive filtering is found to substantially increase pilot gain and cross-over frequency, implying a more tight tracking behavior. The adaptive filter is found to be effective in particular for high-gain proportional dynamics, low display forcing function power and for pursuit tracking task configurations.

  14. Suppression of biodynamic interference in head-tracked teleoperation

    NASA Technical Reports Server (NTRS)

    Lifshitz, S.; Merhav, S. J.; Grunwald, A. J.; Tucker, G. E.; Tischler, M. B.

    1991-01-01

    The utility of helmet-tracked sights to provide pointing commands for teleoperation of cameras, lasers, or antennas in aircraft is degraded by the presence of uncommanded, involuntary heat motion, referred to as biodynamic interference. This interference limits the achievable precision required in pointing tasks. The noise contributions due to biodynamic interference consists of an additive component which is correlated with aircraft vibration and an uncorrelated, nonadditive component, referred to as remnant. An experimental simulation study is described which investigated the improvements achievable in pointing and tracking precision using dynamic display shifting in the helmet-mounted display. The experiment was conducted in a six degree of freedom motion base simulator with an emulated helmet-mounted display. Highly experienced pilot subjects performed precision head-pointing tasks while manually flying a visual flight-path tracking task. Four schemes using adaptive and low-pass filtering of the head motion were evaluated to determine their effects on task performance and pilot workload in the presence of whole-body vibration characteristic of helicopter flight. The results indicate that, for tracking tasks involving continuously moving targets, improvements of up to 70 percent can be achieved in percent on-target dwelling time and of up to 35 percent in rms tracking error, with the adaptive plus low-pass filter configuration. The results with the same filter configuration for the task of capturing randomly-positioned, stationary targets show an increase of up to 340 percent in the number of targets captured and an improvement of up to 24 percent in the average capture time. The adaptive plus low-pass filter combination was considered to exhibit the best overall display dynamics by each of the subjects.

  15. The ORNL Chemical Technology Division, 1950-1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jolley, R.L.; Genung, R.K.; McNeese, L.E.

    1994-10-01

    This document attempts to reconstruct the role played by the Chemical Technology Division (Chem Tech) of the Oak Ridge National Laboratory (ORNL) in the atomic era since the 1940`s related to the development and production of nuclear weapons and power reactors. Chem Tech`s early contributions were landmark pioneering studies. Unknown and dimly perceived problems like chemical hazards, radioactivity, and criticality had to be dealt with. New chemical concepts and processes had to be developed to test the new theories being developed by physicists. New engineering concepts had to be developed and demonstrated in order to build facilities and equipment thatmore » had never before been attempted. Chem Tech`s role was chemical separations, especially uranium and plutonium, and nuclear fuel reprocessing. With diversification of national and ORNL missions, Chem Tech undertook R&D studies in many areas including biotechnology; clinical and environmental chemistry; nuclear reactors; safety regulations; effective and safe waste management and disposal; computer modeling and informational databases; isotope production; and environmental control. The changing mission of Chem Tech are encapsulated in the evolving activities.« less

  16. Biodynamic feedback training to assure learning partial load bearing on forearm crutches.

    PubMed

    Krause, Daniel; Wünnemann, Martin; Erlmann, Andre; Hölzchen, Timo; Mull, Melanie; Olivier, Norbert; Jöllenbeck, Thomas

    2007-07-01

    To examine how biodynamic feedback training affects the learning of prescribed partial load bearing (200N). Three pre-post experiments. Biomechanics laboratory in a German university. A volunteer sample of 98 uninjured subjects who had not used crutches recently. There were 24 subjects in experiment 1 (mean age, 23.2y); 64 in experiment 2 (mean age, 43.6y); and 10 in experiment 3 (mean age, 40.3y), parallelized by arm force. Video instruction and feedback training: In experiment 1, 2 varied instruction videos and reduced feedback frequency; in experiment 2, varied frequencies of changing tasks (contextual interference); and in experiment 3, feedback training (walking) and transfer (stair tasks). Vertical ground reaction force. Absolute error of practiced tasks was significantly reduced for all samples (P<.050). Varied contextual interference conditions did not significantly affect retention (P=.798) or transfer (P=.897). Positive transfer between tasks was significant in experiment 2 (P<.001) and was contrary to findings in experiment 3 (P=.071). Biodynamic feedback training is applicable for learning prescribed partial load bearing. The frequency of changing tasks is irrelevant. Despite some support for transfer effects, additional practice in climbing and descending stairs might be beneficial.

  17. Chemical Technology Division, Annual technical report, 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-03-01

    Highlights of the Chemical Technology (CMT) Division`s activities during 1991 are presented. In this period, CMT conducted research and development in the following areas: (1) electrochemical technology, including advanced batteries and fuel cells; (2) technology for fluidized-bed combustion and coal-fired magnetohydrodynamics; (3) methods for treatment of hazardous and mixed hazardous/radioactive waste; (4) the reaction of nuclear waste glass and spent fuel under conditions expected for an unsaturated repository; (5) processes for separating and recovering transuranic elements from nuclear waste streams; (6) recovery processes for discharged fuel and the uranium blanket in the Integral Fast Reactor (IFR); (7) processes for removalmore » of actinides in spent fuel from commercial water-cooled nuclear reactors and burnup in IFRs; and (8) physical chemistry of selected materials in environments simulating those of fission and fusion energy systems. The Division also conducts basic research in catalytic chemistry associated with molecular energy resources; chemistry of superconducting oxides and other materials of interest with technological application; interfacial processes of importance to corrosion science, catalysis, and high-temperature superconductivity; and the geochemical processes involved in water-rock interactions occurring in active hydrothermal systems. In addition, the Analytical Chemistry Laboratory in CMT provides a broad range of analytical chemistry support services to the technical programs at Argonne National Laboratory (ANL).« less

  18. Construction of a biodynamic model for Cry protein production studies.

    PubMed

    Navarro-Mtz, Ana Karin; Pérez-Guevara, Fermín

    2014-12-01

    Mathematical models have been used from growth kinetic simulation to gen regulatory networks prediction for B. thuringiensis culture. However, this culture is a time dependent dynamic process where cells physiology suffers several changes depending on the changes in the cell environment. Therefore, through its culture, B. thuringiensis presents three phases related with the predominance of three major metabolic pathways: vegetative growth (Embded-Meyerhof-Parnas pathway), transition (γ-aminobutiric cycle) and sporulation (tricarboxylic acid cycle). There is not available a mathematical model that relates the different stages of cultivation with the metabolic pathway active on each one of them. Therefore, in the present study, and based on published data, a biodynamic model was generated to describe the dynamic of the three different phases based on their major metabolic pathways. The biodynamic model is used to study the interrelation between the different culture phases and their relationship with the Cry protein production. The model consists of three interconnected modules where each module represents one culture phase and its principal metabolic pathway. For model validation four new fermentations were done showing that the model constructed describes reasonably well the dynamic of the three phases. The main results of this model imply that poly-β-hydroxybutyrate is crucial for endospore and Cry protein production. According to the yields of dipicolinic acid and Cry from poly-β-hydroxybutyrate, calculated with the model, the endospore and Cry protein production are not just simultaneous and parallel processes they are also competitive processes.

  19. On 4-degree-of-freedom biodynamic models of seated occupants: Lumped-parameter modeling

    NASA Astrophysics Data System (ADS)

    Bai, Xian-Xu; Xu, Shi-Xu; Cheng, Wei; Qian, Li-Jun

    2017-08-01

    It is useful to develop an effective biodynamic model of seated human occupants to help understand the human vibration exposure to transportation vehicle vibrations and to help design and improve the anti-vibration devices and/or test dummies. This study proposed and demonstrated a methodology for systematically identifying the best configuration or structure of a 4-degree-of-freedom (4DOF) human vibration model and for its parameter identification. First, an equivalent simplification expression for the models was made. Second, all of the possible 23 structural configurations of the models were identified. Third, each of them was calibrated using the frequency response functions recommended in a biodynamic standard. An improved version of non-dominated sorting genetic algorithm (NSGA-II) based on Pareto optimization principle was used to determine the model parameters. Finally, a model evaluation criterion proposed in this study was used to assess the models and to identify the best one, which was based on both the goodness of curve fits and comprehensive goodness of the fits. The identified top configurations were better than those reported in the literature. This methodology may also be extended and used to develop the models with other DOFs.

  20. Experimental investigation of biodynamic human body models subjected to whole-body vibration during a vehicle ride.

    PubMed

    Taskin, Yener; Hacioglu, Yuksel; Ortes, Faruk; Karabulut, Derya; Arslan, Yunus Ziya

    2018-02-06

    In this study, responses of biodynamic human body models to whole-body vibration during a vehicle ride were investigated. Accelerations were acquired from three different body parts, such as the head, upper torso and lower torso, of 10 seated passengers during a car ride while two different road conditions were considered. The same multipurpose vehicle was used during all experiments. Additionally, by two widely used biodynamic models in the literature, a set of simulations were run to obtain theoretical accelerations of the models and were compared with those obtained experimentally. To sustain a quantified comparison between experimental and theoretical approaches, the root mean square acceleration and acceleration spectral density were calculated. Time and frequency responses of the models demonstrated that neither of the models showed the best prediction performance of the human body behaviour in all cases, indicating that further models are required for better prediction of the human body responses.

  1. Review and Evaluation of Hand-Arm Coordinate Systems for Measuring Vibration Exposure, Biodynamic Responses, and Hand Forces.

    PubMed

    Dong, Ren G; Sinsel, Erik W; Welcome, Daniel E; Warren, Christopher; Xu, Xueyan S; McDowell, Thomas W; Wu, John Z

    2015-09-01

    The hand coordinate systems for measuring vibration exposures and biodynamic responses have been standardized, but they are not actually used in many studies. This contradicts the purpose of the standardization. The objectives of this study were to identify the major sources of this problem, and to help define or identify better coordinate systems for the standardization. This study systematically reviewed the principles and definition methods, and evaluated typical hand coordinate systems. This study confirms that, as accelerometers remain the major technology for vibration measurement, it is reasonable to standardize two types of coordinate systems: a tool-based basicentric (BC) system and an anatomically based biodynamic (BD) system. However, these coordinate systems are not well defined in the current standard. Definition of the standard BC system is confusing, and it can be interpreted differently; as a result, it has been inconsistently applied in various standards and studies. The standard hand BD system is defined using the orientation of the third metacarpal bone. It is neither convenient nor defined based on important biological or biodynamic features. This explains why it is rarely used in practice. To resolve these inconsistencies and deficiencies, we proposed a revised method for defining the realistic handle BC system and an alternative method for defining the hand BD system. A fingertip-based BD system for measuring the principal grip force is also proposed based on an important feature of the grip force confirmed in this study.

  2. Review and Evaluation of Hand–Arm Coordinate Systems for Measuring Vibration Exposure, Biodynamic Responses, and Hand Forces

    PubMed Central

    Dong, Ren G.; Sinsel, Erik W.; Welcome, Daniel E.; Warren, Christopher; Xu, Xueyan S.; McDowell, Thomas W.; Wu, John Z.

    2015-01-01

    The hand coordinate systems for measuring vibration exposures and biodynamic responses have been standardized, but they are not actually used in many studies. This contradicts the purpose of the standardization. The objectives of this study were to identify the major sources of this problem, and to help define or identify better coordinate systems for the standardization. This study systematically reviewed the principles and definition methods, and evaluated typical hand coordinate systems. This study confirms that, as accelerometers remain the major technology for vibration measurement, it is reasonable to standardize two types of coordinate systems: a tool-based basicentric (BC) system and an anatomically based biodynamic (BD) system. However, these coordinate systems are not well defined in the current standard. Definition of the standard BC system is confusing, and it can be interpreted differently; as a result, it has been inconsistently applied in various standards and studies. The standard hand BD system is defined using the orientation of the third metacarpal bone. It is neither convenient nor defined based on important biological or biodynamic features. This explains why it is rarely used in practice. To resolve these inconsistencies and deficiencies, we proposed a revised method for defining the realistic handle BC system and an alternative method for defining the hand BD system. A fingertip-based BD system for measuring the principal grip force is also proposed based on an important feature of the grip force confirmed in this study. PMID:26929824

  3. Symposium introduction: the first joint American Chemical Society Agricultural and Food Chemistry Division and the American Chemical Society International Chemical Sciences Chapter in Thailand

    USDA-ARS?s Scientific Manuscript database

    The American Chemical Society (ACS) Agricultural and Food Chemistry Division (AGFD) and the ACS International Chemical Sciences Chapter in Thailand (ICSCT) worked together to stage the “1st Joint ACS AGFD - ACS ICSCT Symposium on Agricultural and Food Chemistry,” which was held in Bangkok, Thailand ...

  4. Biodynamic modelling of the accumulation of Ag, Cd and Zn by the deposit-feeding polychaete Nereis diversicolor: inter-population variability and a generalised predictive model.

    PubMed

    Kalman, J; Smith, B D; Riba, I; Blasco, J; Rainbow, P S

    2010-06-01

    Biodynamic parameters of the ragworm Nereis diversicolor from southern Spain and south England were experimentally derived to assess the inter-population variability of physiological parameters of the bioaccumulation of Ag, Cd and Zn from water and sediment. Although there were some limited variations, these were not consistent with the local metal bioavailability nor with temperature changes. Incorporating the biodynamic parameters into a defined biodynamic model, confirmed that sediment is the predominant source of Cd and Zn accumulated by the worms, accounting in each case for 99% of the overall accumulated metals, whereas the contribution of dissolved Ag to the total accumulated by the worm increased from about 27 to about 53% with increasing dissolved Ag concentration. Standardised values of metal-specific parameters were chosen to generate a generalised model to be extended to N. diversicolor populations across a wide geographical range from western Europe to North Africa. According to the assumptions of this model, predicted steady state concentrations of Cd and Zn in N. diversicolor were overestimated, those of Ag underestimated, but still comparable to independent field measurements. We conclude that species-specific physiological metal bioaccumulation parameters are relatively constant over large geographical distances, and a single generalised biodynamic model does have potential to predict accumulated Ag, Cd and Zn concentrations in this polychaete from a single sediment metal concentration.

  5. Hazardous Waste Cleanup: Fisher Scientific Chemical Division in Fair Lawn, New Jersey

    EPA Pesticide Factsheets

    Fisher Scientific Chemical Division occupies a 10-acre site at 1 Reagent Lane in the Fair Lawn Industrial Park, New Jersey. Since 1955, Fisher has formulated, distilled, repackaged and distributed high-purity, laboratory-grade reagents and solvents.

  6. Establishing the Biodynamics Data Resource (BDR): Human Volunteer Impact Acceleration Research Data in the BDR

    DTIC Science & Technology

    2009-10-01

    accelerations (+Z) were applied to HRVs in the supine position to mimic the acceleration of an ejection seat , while runs simulating aircraft crashes were...Naval Biodynamics Laboratory, 1985). The vertical testing provided a more authentic ejection seat simulation than was achievable using axial...impact acceleration exposures with hundreds of human research volunteers. The resulting volumes of kinematic and physiological data serve as a

  7. Proceedings of the frst joint american chemical society agricultural and food chemistry division – american chemical society international chemical sciences chapter in Thailand symposium on agricultural and food chemistry

    USDA-ARS?s Scientific Manuscript database

    This Proceedings is a compilation of papers from contributed oral and poster presentations presented at the first joint symposium organized by the American Chemical Society Agricultural and Food Chemistry Division and the American Chemical Society International Chemical Sciences Chapter in Thailand ...

  8. Chemical Technology Division, Annual technical report, 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-03-01

    Highlights of the Chemical Technology (CMT) Division's activities during 1991 are presented. In this period, CMT conducted research and development in the following areas: (1) electrochemical technology, including advanced batteries and fuel cells; (2) technology for fluidized-bed combustion and coal-fired magnetohydrodynamics; (3) methods for treatment of hazardous and mixed hazardous/radioactive waste; (4) the reaction of nuclear waste glass and spent fuel under conditions expected for an unsaturated repository; (5) processes for separating and recovering transuranic elements from nuclear waste streams; (6) recovery processes for discharged fuel and the uranium blanket in the Integral Fast Reactor (IFR); (7) processes for removalmore » of actinides in spent fuel from commercial water-cooled nuclear reactors and burnup in IFRs; and (8) physical chemistry of selected materials in environments simulating those of fission and fusion energy systems. The Division also conducts basic research in catalytic chemistry associated with molecular energy resources; chemistry of superconducting oxides and other materials of interest with technological application; interfacial processes of importance to corrosion science, catalysis, and high-temperature superconductivity; and the geochemical processes involved in water-rock interactions occurring in active hydrothermal systems. In addition, the Analytical Chemistry Laboratory in CMT provides a broad range of analytical chemistry support services to the technical programs at Argonne National Laboratory (ANL).« less

  9. Ernst Haeckel's biodynamics 1866 and the occult basis of organic farming

    PubMed Central

    Kutschera, Ulrich

    2016-01-01

    ABSTRACT One hundred and 50 years ago (Sept. 1866), Ernst Haeckel published a monograph entitled General Morphology of Organisms, wherein key terms, such as Protista, Monera, ontogeny, phylogeny, ecology and the ‘biogenetic law’ where introduced. In addition, Haeckel coined the word “biodynamics” as a synonym for “general physiology.” In contrast, Rudolf Steiner's “biodynamic agriculture,” which originated in 1924, and was promoted via Ehrenfried Pfeiffer's book of 1938 with the same title, is an occult pseudoscience still popular today. The misuse of Haeckel's term to legitimize disproven homeopathic principles and esoteric rules within the context of applied plant research is unacceptable. PMID:27322020

  10. The relationships between hand coupling force and vibration biodynamic responses of the hand-arm system.

    PubMed

    Pan, Daniel; Xu, Xueyan S; Welcome, Daniel E; McDowell, Thomas W; Warren, Christopher; Wu, John; Dong, Ren G

    2018-06-01

    This study conducted two series of experiments to investigate the relationships between hand coupling force and biodynamic responses of the hand-arm system. In the first experiment, the vibration transmissibility on the system was measured as a continuous function of grip force while the hand was subjected to discrete sinusoidal excitations. In the second experiment, the biodynamic responses of the system subjected to a broadband random vibration were measured under five levels of grip forces and a combination of grip and push forces. This study found that the transmissibility at each given frequency increased with the increase in the grip force before reaching a maximum level. The transmissibility then tended to plateau or decrease when the grip force was further increased. This threshold force increased with an increase in the vibration frequency. These relationships remained the same for both types of vibrations. The implications of the experimental results are discussed. Practitioner Summary: Shocks and vibrations transmitted to the hand-arm system may cause injuries and disorders of the system. How to take hand coupling force into account in the risk assessment of vibration exposure remains an important issue for further studies. This study is designed and conducted to help resolve this issue.

  11. 75 FR 879 - National Starch and Chemical Company Specialty Starches Division Including On-Site Leased Workers...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-06

    ... DEPARTMENT OF LABOR Employment and Training Administration [TA-W-62,282] National Starch and Chemical Company Specialty Starches Division Including On-Site Leased Workers From Page Employment, Island... Adjustment Assistance on December 13, 2007, applicable to workers of National Starch and Chemical Company...

  12. Subsurface high resolution definition of subsurface heterogeneity for understanding the biodynamics of natural field systems: Advancing the ability for scaling to field conditions. 1998 annual progress report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Majer, E.L.; Brockman, F.J.

    1998-06-01

    'This research is an integrated physical (geophysical and hydrologic) and microbial study using innovative geophysical imaging and microbial characterization methods to identify key scales of physical heterogeneities that affect the biodynamics of natural subsurface environments. Data from controlled laboratory and in-situ experiments at the INEEL Test Area North (TAN) site are being used to determine the dominant physical characteristics (lithologic, structural, and hydrologic) that can be imaged in-situ and correlated with microbial properties. The overall goal of this research is to contribute to the understanding of the interrelationships between transport properties and spatially varying physical, chemical, and microbiological heterogeneity. Themore » outcome will be an improved understanding of the relationship between physical and microbial heterogeneity, thus facilitating the design of bioremediation strategies in similar environments. This report summarizes work as of May 1998, the second year of the project. This work is an extension of basic research on natural heterogeneity first initiated within the DOE/OHER Subsurface Science Program (SSP) and is intended to be one of the building blocks of an integrated and collaborative approach with an INEEL/PNNL effort aimed at understanding the effect of physical heterogeneity on transport properties and biodynamics in natural systems. The work is closely integrated with other EMSP projects at INEEL (Rick Colwell et al.) and PNNL (Fred Brockman and Jim Fredrickson).'« less

  13. OFC: People, and a drum of know-how. [Oil Field Chemicals division of Exxon

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1978-01-01

    The Oil Field Chemicals (OFC) division of Exxon Chemical USA story is one more of people than products, more one of selling through experience than selling through persuasion. OFC sales representatives direct teams dedicated to solving problems in the oil field, pipelines, refineries, and petrochemical plants. The major enemy in oil production is water. When a reservoir is first produced the oil is fairly dry. In time, water comes and with it a host of problems: stable emulsions, corrosion that eats at pipes and equipment, scaling, and bacterial growth. This brings into play the know-how of OFC people and theirmore » ability to diagnose the problem and make the right recommendation. If their field evaluations are inconclusive they will call for help from technical specialists in the Chemical Specialties Technology division for specific situations. These specialists travel to the site, run tests, then quickly develop alternatives. Depending on the solution, the Houston Chemical Plant may be called on to manufacture blends in commercial quantities in a remarkably short period of time. How some of these field problems were solved are described.« less

  14. Experimentally fitted biodynamic models for pedestrian-structure interaction in walking situations

    NASA Astrophysics Data System (ADS)

    Toso, Marcelo André; Gomes, Herbert Martins; da Silva, Felipe Tavares; Pimentel, Roberto Leal

    2016-05-01

    The interaction between moving humans and structures usually occurs in slender structures in which the level of vibration is potentially high. Furthermore, there is the addition of mass to the structural system due to the presence of people and an increase in damping due to the human body´s ability to absorb vibrational energy. In this paper, a test campaign is presented to obtain parameters for a single degree of freedom (SDOF) biodynamic model that represents the action of a walking pedestrian in the vertical direction. The parameters of this model are the mass (m), damping (c) and stiffness (k). The measurements were performed on a force platform, and the inputs were the spectral acceleration amplitudes of the first three harmonics at the waist level of the test subjects and the corresponding amplitudes of the first three harmonics of the vertical ground reaction force. This leads to a system of nonlinear equations that is solved using a gradient-based optimization algorithm. A set of individuals took part in the tests to ensure inter-subject variability, and, regression expressions and an artificial neural network (ANN) were used to relate the biodynamic parameters to the pacing rate and the body mass of the pedestrians. The results showed some scatter in damping and stiffness that could not be precisely correlated with the masses and pacing rates of the subjects. The use of the ANN resulted in significant improvements in the parameter expressions with a low uncertainty. Finally, the measured vertical accelerations on a prototype footbridge show the adequacy of the numerical model for the representation of the effects of walking pedestrians on a structure. The results are consistent for many crowd densities.

  15. AN OVERVIEW OF PATHOGEN RESEARCH IN THE MICROBIOLOGICAL AND CHEMICAL EXPOSURE ASSESSMENT RESEARCH DIVISION

    EPA Science Inventory

    The Microbiological and Chemical Exposure Assessment Research Division of the EPA Office of Research and Development's National Exposure Research Laboratory has a robust in-house research program aimed at developing better occurrence and exposure methods for waterborne pathogens....

  16. Chemical Technology Division annual technical report, 1990

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1991-05-01

    Highlights of the Chemical Technology (CMT) Division's activities during 1990 are presented. In this period, CMT conducted research and development in the following areas: (1) electrochemical technology, including advanced batteries and fuel cells; (2) technology for coal- fired magnetohydrodynamics and fluidized-bed combustion; (3) methods for recovery of energy from municipal waste and techniques for treatment of hazardous organic waste; (4) the reaction of nuclear waste glass and spent fuel under conditions expected for a high-level waste repository; (5) processes for separating and recovering transuranic elements from nuclear waste streams, concentrating plutonium solids in pyrochemical residues by aqueous biphase extraction, andmore » treating natural and process waters contaminated by volatile organic compounds; (6) recovery processes for discharged fuel and the uranium blanket in the Integral Fast Reactor (IFR); (7) processes for removal of actinides in spent fuel from commercial water-cooled nuclear reactors and burnup in IFRs; and (8) physical chemistry of selected materials in environments simulating those of fission and fusion energy systems. The Division also has a program in basic chemistry research in the areas of fluid catalysis for converting small molecules to desired products; materials chemistry for superconducting oxides and associated and ordered solutions at high temperatures; interfacial processes of importance to corrosion science, high-temperature superconductivity, and catalysis; and the geochemical processes responsible for trace-element migration within the earth's crust. The Analytical Chemistry Laboratory in CMT provides a broad range of analytical chemistry support services to the scientific and engineering programs at Argonne National Laboratory (ANL). 66 refs., 69 figs., 6 tabs.« less

  17. Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division: July--September 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jubin, R.T.

    This report summarizes the major activities conducted in the Chemical and Energy Research Section of the Chemical Technology Division at Oak Ridge National Laboratory (ORNL) during the period July--September 1997. The section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within nine major areas of research: Hot Cell Operations, Process Chemistry and Thermodynamics, Molten Salt Reactor Experiment (MSRE) Remediation Studies, Chemistry Research, Biotechnology, Separations and Materials Synthesis, Fluid Structure and Properties, Biotechnologymore » Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.« less

  18. Human body modeling method to simulate the biodynamic characteristics of spine in vivo with different sitting postures.

    PubMed

    Dong, Rui-Chun; Guo, Li-Xin

    2017-11-01

    The aim of this study is to model the computational model of seated whole human body including skeleton, muscle, viscera, ligament, intervertebral disc, and skin to predict effect of the factors (sitting postures, muscle and skin, buttocks, viscera, arms, gravity, and boundary conditions) on the biodynamic characteristics of spine. Two finite element models of seated whole body and a large number of finite element models of different ligamentous motion segments were developed and validated. Static, modal, and transient dynamic analyses were performed. The predicted vertical resonant frequency of seated body model was in the range of vertical natural frequency of 4 to 7 Hz. Muscle, buttocks, viscera, and the boundary conditions of buttocks have influence on the vertical resonant frequency of spine. Muscle played a very important role in biodynamic response of spine. Compared with the vertical posture, the posture of lean forward or backward led to an increase in stress on anterior or lateral posterior of lumbar intervertebral discs. This indicated that keeping correct posture could reduce the injury of vibration on lumbar intervertebral disc under whole-body vibration. The driving posture not only reduced the load of spine but also increased the resonant frequency of spine. Copyright © 2017 John Wiley & Sons, Ltd.

  19. Common-path biodynamic imaging for dynamic fluctuation spectroscopy of 3D living tissue

    NASA Astrophysics Data System (ADS)

    Li, Zhe; Turek, John; Nolte, David D.

    2017-03-01

    Biodynamic imaging is a novel 3D optical imaging technology based on short-coherence digital holography that measures intracellular motions of cells inside their natural microenvironments. Here both common-path and Mach-Zehnder designs are presented. Biological tissues such as tumor spheroids and ex vivo biopsies are used as targets, and backscattered light is collected as signal. Drugs are applied to samples, and their effects are evaluated by identifying biomarkers that capture intracellular dynamics from the reconstructed holograms. Through digital holography and coherence gating, information from different depths of the samples can be extracted, enabling the deep-tissue measurement of the responses to drugs.

  20. Establishment of one-axis vibration test system for measurement of biodynamic response of human hand-arm system.

    PubMed

    Shibata, Nobuyuki; Hosoya, Naoki; Maeda, Setsuo

    2008-12-01

    Prolonged exposure to hand-arm vibration (HAV) due to use of hand-held power tools leads to an increased occurrence of symptoms of disorders in the vascular, neurological, and osteo-articular systems of the upper limbs called hand-arm vibration syndrome (HAVS). Biodynamic responses of the hand-arm system to vibration can be suggestive parameters that give us better assessment of exposure to HAV and fundamental data for design of low-vibration-exposure power tools. Recently, a single axis hand-arm vibration system has been installed in the Japan National Institute of Occupational Safety and Health (NIOSH). The aims of this study were to obtain the fundamental dynamic characteristics of an instrumented handle and to validate the performance and measurement accuracy of the system applied to dynamic response measurement. A pseudo-random vibration signal with a frequency range of 5-1,250 Hz and a power spectrum density of 1.0 (m/s2)2/Hz was used in this study. First the dynamic response of the instrumented handle without any weight was measured. After this measurement, the dynamic response measurement of the handle with weights mounted on the handle was performed. The apparent mass of a weight itself was obtained by using the mass cancellation method. The mass of the measuring cap on the instrumented handle was well compensated by using the mass cancellation method. Based on the 10% error tolerance, this handle can reliably measure the dynamic response represented by an apparent mass with a minimum weight of 2.0 g in a frequency range of 10.0 to 1,000 Hz. A marked increase in the AM magnitude of the weights of 15 g and 20 g in frequency ranges greater than 800 Hz is attributed not to the fundamental resonance frequency of the handle with weights, but to the fixation of the weight to the measuring cap. In this aspect, the peak of the AM magnitude can be reduced and hence should not be an obstacle to the biodynamic response measurement of the human hand-arm system. On the

  1. Are Epiphytic Microbial Communities in the Carposphere of Ripening Grape Clusters (Vitis vinifera L.) Different between Conventional, Organic, and Biodynamic Grapes?

    PubMed

    Kecskeméti, Elizabeth; Berkelmann-Löhnertz, Beate; Reineke, Annette

    2016-01-01

    Using barcoded pyrosequencing fungal and bacterial communities associated with grape berry clusters (Vitis vinifera L.) obtained from conventional, organic and biodynamic vineyard plots were investigated in two subsequent years at different stages during berry ripening. The four most abundant operational taxonomic units (OTUs) based on fungal ITS data were Botrytis cinerea, Cladosporium spp., Aureobasidium pullulans and Alternaria alternata which represented 57% and 47% of the total reads in 2010 and 2011, respectively. Members of the genera Sphingomonas, Gluconobacter, Pseudomonas, Erwinia, and Massilia constituted 67% of the total number of bacterial 16S DNA reads in 2010 samples and 78% in 2011 samples. Viticultural management system had no significant effect on abundance of fungi or bacteria in both years and at all three sampling dates. Exceptions were A. alternata and Pseudomonas spp. which were more abundant in the carposphere of conventional compared to biodynamic berries, as well as Sphingomonas spp. which was significantly less abundant on conventional compared to organic berries at an early ripening stage in 2011. In general, there were no significant differences in fungal and bacterial diversity indices or richness evident between management systems. No distinct fungal or bacterial communities were associated with the different maturation stages or management systems, respectively. An exception was the last stage of berry maturation in 2011, where the Simpson diversity index was significantly higher for fungal communities on biodynamic compared to conventional grapes. Our study highlights the existence of complex and dynamic microbial communities in the grape cluster carposphere including both phytopathogenic and potentially antagonistic microorganisms that can have a significant impact on grape production. Such knowledge is particularly relevant for development, selection and application of effective control measures against economically important

  2. Are Epiphytic Microbial Communities in the Carposphere of Ripening Grape Clusters (Vitis vinifera L.) Different between Conventional, Organic, and Biodynamic Grapes?

    PubMed Central

    Kecskeméti, Elizabeth; Berkelmann-Löhnertz, Beate; Reineke, Annette

    2016-01-01

    Using barcoded pyrosequencing fungal and bacterial communities associated with grape berry clusters (Vitis vinifera L.) obtained from conventional, organic and biodynamic vineyard plots were investigated in two subsequent years at different stages during berry ripening. The four most abundant operational taxonomic units (OTUs) based on fungal ITS data were Botrytis cinerea, Cladosporium spp., Aureobasidium pullulans and Alternaria alternata which represented 57% and 47% of the total reads in 2010 and 2011, respectively. Members of the genera Sphingomonas, Gluconobacter, Pseudomonas, Erwinia, and Massilia constituted 67% of the total number of bacterial 16S DNA reads in 2010 samples and 78% in 2011 samples. Viticultural management system had no significant effect on abundance of fungi or bacteria in both years and at all three sampling dates. Exceptions were A. alternata and Pseudomonas spp. which were more abundant in the carposphere of conventional compared to biodynamic berries, as well as Sphingomonas spp. which was significantly less abundant on conventional compared to organic berries at an early ripening stage in 2011. In general, there were no significant differences in fungal and bacterial diversity indices or richness evident between management systems. No distinct fungal or bacterial communities were associated with the different maturation stages or management systems, respectively. An exception was the last stage of berry maturation in 2011, where the Simpson diversity index was significantly higher for fungal communities on biodynamic compared to conventional grapes. Our study highlights the existence of complex and dynamic microbial communities in the grape cluster carposphere including both phytopathogenic and potentially antagonistic microorganisms that can have a significant impact on grape production. Such knowledge is particularly relevant for development, selection and application of effective control measures against economically important

  3. Program for the Division of Chemical Education: Chicago, March 25 29, 2007

    NASA Astrophysics Data System (ADS)

    Middlecamp, Catherine H.; Bodner, George M.; Jones, Wayne E., Jr.

    2007-03-01

    Program for the Division of Chemical Education March 2007 meeting in Chicago. All CHED technical sessions including the High School Program will be held in the McCormick Place Convention Complex North, 2301 South Lake Shore Drive. Exceptions are the Undergraduate Program (in the Westin Hotel Michigan Avenue), the Undergraduate Research Poster Sessions (in the Sheraton Chicago Hotel), and any evening programs. Unless otherwise noted, morning sessions begin at 8:30 a.m., afternoon sessions at 1:30 p.m.

  4. The past and future of chemical information - A report of the Chemical Information Division Session of the 200th Meeting of the American Chemical Society

    NASA Astrophysics Data System (ADS)

    Tokizane, Soichi

    At the historical meeting of the ACS CINF Division, the 1990 Herman Skolnik Award was presented to Dr. Ernst Meyer, who at BASF in Germany had developed a computer storage and retrieval system of chemical structures in 1960s. His and his colleagues' speeches in the award symposium were about the history of the development of chemical structure information in Germany. In the symposium of the Markush structure system, a hottest topic in this field, CAS's MARPAT and Markush-DARC co-developed by Questel, INPI, and Derwent were discussed by many papers. Other topics of this meeting were discussed, too.

  5. Chemical Technology Division: Progress report, January 1, 1987--June 30, 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1989-02-01

    This progress report summarizes the research and development efforts conducted in the Chemical Technology Division (Chem Tech) during the period January 1, 1987, to June 30, 1988. The following major areas are covered: waste management and environmental programs, radiochemical and reactor engineering programs, basic science and technology, Nuclear Regulatory Commission programs, and administrative resources and facilities. The Administrative Summary, an appendix, presents a comprehensive listing of publications, oral presentations, awards and recognitions, and patents of Chem Tech staff members during this period. A staffing level and financial summary and lists of seminars and Chem Tech consultants for the period aremore » also included.« less

  6. Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division: October-December 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jubin, R.T.

    This report summarizes the major activities conducted in the Chemical and Energy Research Section of the Chemical Technology Division at Oak Ridge National Laboratory (ORNL) during the period October--December 1997. The section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within six major areas of research: Hot Cell Operations, Process Chemistry and Thermodynamics, Separations and Materials Synthesis, Fluid Structure and Properties, Biotechnology Research, and Molecular Studies. The name of a technical contactmore » is included with each task described, and readers are encouraged to contact these individuals if they need additional information. Activities conducted within the area of Hot Cell Operations included efforts to optimize the processing conditions for Enhanced Sludge Washing of Hanford tank sludge, the testing of candidate absorbers and ion exchangers under continuous-flow conditions using actual supernatant from the Melton Valley Storage Tanks, and attempts to develop a cesium-specific spherical inorganic sorbent for the treatment of acidic high-salt waste solutions. Within the area of Process Chemistry and Thermodynamics, the problem of solids formation in process solutions from caustic treatment of Hanford sludge was addressed and experimental collaborative efforts with Russian scientists to determine the solidification conditions of yttrium barium, and copper oxides from their melts were completed.« less

  7. Biodynamic imaging for phenotypic profiling of three-dimensional tissue culture

    NASA Astrophysics Data System (ADS)

    Sun, Hao; Merrill, Daniel; An, Ran; Turek, John; Matei, Daniela; Nolte, David D.

    2017-01-01

    Three-dimensional (3-D) tissue culture represents a more biologically relevant environment for testing new drugs compared to conventional two-dimensional cancer cell culture models. Biodynamic imaging is a high-content 3-D optical imaging technology based on low-coherence interferometry and digital holography that uses dynamic speckle as high-content image contrast to probe deep inside 3-D tissue. Speckle contrast is shown to be a scaling function of the acquisition time relative to the persistence time of intracellular transport and hence provides a measure of cellular activity. Cellular responses of 3-D multicellular spheroids to paclitaxel are compared among three different growth techniques: rotating bioreactor (BR), hanging-drop (HD), and nonadherent (U-bottom, UB) plate spheroids, compared with ex vivo living tissues. HD spheroids have the most homogeneous tissue, whereas BR spheroids display large sample-to-sample variability as well as spatial heterogeneity. The responses of BR-grown tumor spheroids to paclitaxel are more similar to those of ex vivo biopsies than the responses of spheroids grown using HD or plate methods. The rate of mitosis inhibition by application of taxol is measured through tissue dynamics spectroscopic imaging, demonstrating the ability to monitor antimitotic chemotherapy. These results illustrate the potential use of low-coherence digital holography for 3-D pharmaceutical screening applications.

  8. Role of Prolactin in the Regulation of Bicarbonates Biodynamics in Female Rat Model of Cholestasis of Pregnancy.

    PubMed

    Bulaeva, O A; Abramicheva, P A; Balakina, T A; Smirnova, O V

    2017-03-01

    We studied possible involvement of prolactin in the regulation of bicarbonate biodynamics using female rat model of cholestasis of pregnancy induced by transplantation of the donor pituitary under the renal capsule of a recipient (hyperprolactinemia) and bile duct ligation (cholestasis). The concentration of bicarbonates in the bile and blood, their excretion, clearance, and reabsorption, as well as glomerular filtration rate and excretion of sodium ions were assessed. It was found that the main effect of prolactin was directed to the kidney-regulated pool of bicarbonates and consisted in stimulation of their clearance and inhibition of reabsorption, which led to a decrease in bicarbonate blood concentration. Parallel influence of prolactin on the clearance of bicarbonates and sodium ions was observed.

  9. Contacts in the Office of Pesticide Programs, Registration Division

    EPA Pesticide Factsheets

    The Registration Division (RD) is responsible product registrations, amendments, registrations, tolerances, experimental use permits, and emergency exemptions for conventional chemical pesticides. Find contacts in this division.

  10. Nonlinear dual-axis biodynamic response of the semi-supine human body during vertical whole-body vibration

    NASA Astrophysics Data System (ADS)

    Huang, Ya; Griffin, Michael J.

    2008-04-01

    Nonlinear biodynamic responses are evident in many studies of the apparent masses of sitting and standing subjects in static postures that require muscle activity for postural control. In the present study, 12 male subjects adopted a relaxed semi-supine posture assumed to involve less muscle activity than during static sitting and standing. The supine subjects were exposed to two types of vertical vibration (in the x-axis of the semi-supine body): (i) continuous random vibration (0.25-20 Hz) at five magnitudes (0.125, 0.25, 0.5, 0.75, and 1.0 m s -2 rms); (ii) intermittent random vibration (0.25-20 Hz) alternately at 0.25 and 1.0 m s -2 rms. With continuous random vibration, the dominant primary resonance frequency in the median normalised apparent mass decreased from 10.35 to 7.32 Hz as the vibration magnitude increased from 0.125 to 1.0 m s -2 rms. This nonlinear response was apparent in both the vertical ( x-axis) apparent mass and in the horizontal ( z-axis) cross-axis apparent mass. As the vibration magnitude increased from 0.25 to 1.0 m s -2 rms, the median resonance frequency of the apparent mass with intermittent random vibration decreased from 9.28 to 8.06 Hz whereas, over the same range of magnitudes with continuous random vibration, the resonance frequency decreased from 9.62 to 7.81 Hz. The median change in the resonance frequency (between 0.25 and 1.0 m s -2 rms) was 1.37 Hz with the intermittent random vibration and 1.71 with the continuous random vibration. With the intermittent vibration, the resonance frequency was higher at the high magnitude and lower at the low magnitude than with continuous vibration of the same magnitudes. The response was typical of thixotropy that may be a primary cause of the nonlinear biodynamic responses to whole-body vibration.

  11. Earth Sciences Division

    NASA Astrophysics Data System (ADS)

    1991-06-01

    This Annual Report presents summaries of selected representative research activities grouped according to the principal disciplines of the Earth Sciences Division: Reservoir Engineering and Hydrogeology, Geology and Geochemistry, and Geophysics and Geomechanics. Much of the Division's research deals with the physical and chemical properties and processes in the earth's crust, from the partially saturated, low-temperature near-surface environment to the high-temperature environments characteristic of regions where magmatic-hydrothermal processes are active. Strengths in laboratory and field instrumentation, numerical modeling, and in situ measurement allow study of the transport of mass and heat through geologic media -- studies that now include the appropriate chemical reactions and the hydraulic-mechanical complexities of fractured rock systems. Of particular note are three major Division efforts addressing problems in the discovery and recovery of petroleum, the application of isotope geochemistry to the study of geodynamic processes and earth history, and the development of borehole methods for high-resolution imaging of the subsurface using seismic and electromagnetic waves. In 1989, a major DOE-wide effort was launched in the areas of Environmental Restoration and Waste Management. Many of the methods previously developed for and applied to deeper regions of the earth will, in the coming years, be turned toward process definition and characterization of the very shallow subsurface, where man-induced contaminants now intrude and where remedial action is required.

  12. Biodynamic imaging for phenotypic profiling of three-dimensional tissue culture

    PubMed Central

    Sun, Hao; Merrill, Daniel; An, Ran; Turek, John; Matei, Daniela; Nolte, David D.

    2017-01-01

    Abstract. Three-dimensional (3-D) tissue culture represents a more biologically relevant environment for testing new drugs compared to conventional two-dimensional cancer cell culture models. Biodynamic imaging is a high-content 3-D optical imaging technology based on low-coherence interferometry and digital holography that uses dynamic speckle as high-content image contrast to probe deep inside 3-D tissue. Speckle contrast is shown to be a scaling function of the acquisition time relative to the persistence time of intracellular transport and hence provides a measure of cellular activity. Cellular responses of 3-D multicellular spheroids to paclitaxel are compared among three different growth techniques: rotating bioreactor (BR), hanging-drop (HD), and nonadherent (U-bottom, UB) plate spheroids, compared with ex vivo living tissues. HD spheroids have the most homogeneous tissue, whereas BR spheroids display large sample-to-sample variability as well as spatial heterogeneity. The responses of BR-grown tumor spheroids to paclitaxel are more similar to those of ex vivo biopsies than the responses of spheroids grown using HD or plate methods. The rate of mitosis inhibition by application of taxol is measured through tissue dynamics spectroscopic imaging, demonstrating the ability to monitor antimitotic chemotherapy. These results illustrate the potential use of low-coherence digital holography for 3-D pharmaceutical screening applications. PMID:28301634

  13. Biodynamic modeling of PCB uptake by Macoma balthica and Corbicula fluminea from sediment amended with activated carbon

    USGS Publications Warehouse

    McLeod, Pamela B.; Luoma, S.N.; Luthy, R.G.

    2008-01-01

    Activated carbon amendment was assessed in the laboratory as a remediation strategy for freshwater sediment contaminated with polychlorinated biphenyls (PCBs) from the Grasse River (near Massena, NY). Three end points were evaluated: aqueous equilibrium PCB concentration, uptake into semipermeable membrane devices (SPMDs), and 28-day bioaccumulation in the clam Corbicula fluminea. PCB uptake by water, SPMDs, and clams followed similar trends, with reductions increasing as a function of carbon dose. Average percent reductions in clam tissue PCBs were 67, 86, and 95% for activated carbon doses of 0.7, 1.3, and 2.5% dry wt, respectively. A biodynamic model that incorporates sediment geochemistry and dietary and aqueous uptake routes was found to agree well with observed uptake by C. fluminea in our laboratory test systems. Results from this study were compared to 28-day bioaccumulation experiments involving PCB-contaminated sediment from Hunters Point Naval Shipyard (San Francisco Bay, CA) and the clam Macoma balthica. Due to differences in feeding strategy, M. balthica deposit-feeds whereas C. fluminea filter-feeds, the relative importance of the aqueous uptake route is predicted to be much higher for C. fluminea than for M. balthica. Whereas M. balthica takes up approximately 90% of its body burden through sediment ingestion, C. fluminea only accumulates approximately 45% via this route. In both cases, results strongly suggest that it is the mass transfer of PCBs from native sediment to added carbon particles, not merely reductions in aqueous PCB concentrations, that effectively reduces PCB bioavailability and uptake by sediment-dwelling organisms. ?? 2008 American Chemical Society.

  14. Nonlinear dual-axis biodynamic response of the semi-supine human body during longitudinal horizontal whole-body vibration

    NASA Astrophysics Data System (ADS)

    Huang, Ya; Griffin, Michael J.

    2008-04-01

    The resonance frequencies in frequency response functions of the human body (e.g. apparent mass and transmissibility) decrease with increasing vibration magnitude. This nonlinear biodynamic response is found with various sitting and standing postures requiring postural control. The present study measured the apparent mass of the body in a relaxed semi-supine posture with two types of longitudinal horizontal vibration (in the z-axis of the semi-supine body): (i) continuous random excitation (0.25-20 Hz) at five magnitudes (0.125, 0.25, 0.5, 0.75 and 1.0 ms -2 rms); (ii) intermittent random excitation (0.25-20 Hz) alternately at 0.25 and 1.0 ms -2 rms. With continuous random vibration, the dominant primary resonance frequency in the median normalised apparent mass decreased from 3.7 to 2.4 Hz as the vibration magnitude increased from 0.125 to 1.0 ms -2 rms. A nonlinear response was apparent in both the horizontal ( z-axis) apparent mass and the vertical ( x-axis) cross-axis apparent mass. With intermittent random vibration, as the vibration magnitude increased from 0.25 to 1.0 ms -2 rms, the median resonance frequency of the apparent mass decreased from 3.2 to 2.5 Hz whereas, with continuous random vibration over the same range of magnitudes, the resonance frequency decreased from 3.4 to 2.4 Hz. The median change in the resonance frequency (between 0.25 and 1.0 ms -2 rms) was 0.6 Hz with the intermittent random vibration and 0.9 Hz with the continuous random vibration. With intermittent vibration, the resonance frequency was higher at the high magnitude and lower at the low magnitude than with continuous vibration at the same magnitudes. The responses were consistent with passive thixotropy being a primary cause of nonlinear biodynamic responses to whole-body vibration, although reflex activity of the muscles may also have an influence.

  15. Intracellular Doppler Signatures of Platinum Sensitivity Captured by Biodynamic Profiling in Ovarian Xenografts

    NASA Astrophysics Data System (ADS)

    Merrill, Daniel; An, Ran; Sun, Hao; Yakubov, Bakhtiyor; Matei, Daniela; Turek, John; Nolte, David

    2016-01-01

    Three-dimensional (3D) tissue cultures are replacing conventional two-dimensional (2D) cultures for applications in cancer drug development. However, direct comparisons of in vitro 3D models relative to in vivo models derived from the same cell lines have not been reported because of the lack of sensitive optical probes that can extract high-content information from deep inside living tissue. Here we report the use of biodynamic imaging (BDI) to measure response to platinum in 3D living tissue. BDI combines low-coherence digital holography with intracellular Doppler spectroscopy to study tumor drug response. Human ovarian cancer cell lines were grown either in vitro as 3D multicellular monoculture spheroids or as xenografts in nude mice. Fragments of xenografts grown in vivo in nude mice from a platinum-sensitive human ovarian cell line showed rapid and dramatic signatures of induced cell death when exposed to platinum ex vivo, while the corresponding 3D multicellular spheroids grown in vitro showed negligible response. The differences in drug response between in vivo and in vitro growth have important implications for predicting chemotherapeutic response using tumor biopsies from patients or patient-derived xenografts.

  16. Materials dispersion and biodynamics project research

    NASA Technical Reports Server (NTRS)

    Lewis, Marian L.

    1992-01-01

    The Materials Dispersion and Biodynamics Project (MDBP) focuses on dispersion and mixing of various biological materials and the dynamics of cell-to-cell communication and intracellular molecular trafficking in microgravity. Research activities encompass biomedical applications, basic cell biology, biotechnology (products from cells), protein crystal development, ecological life support systems (involving algae and bacteria), drug delivery (microencapsulation), biofilm deposition by living organisms, and hardware development to support living cells on Space Station Freedom (SSF). Project goals are to expand the existing microgravity science database through experiments on sounding rockets, the Shuttle, and COMET program orbiters and to evolve,through current database acquisition and feasibility testing, to more mature and larger-scale commercial operations on SSF. Maximized utilization of SSF for these science applications will mean that service companies will have a role in providing equipment for use by a number of different customers. An example of a potential forerunner of such a service for SSF is the Materials Dispersion Apparatus (MDA) 'mini lab' of Instrumentation Technology Associates, Inc. (ITA) in use on the Shuttle for the Commercial MDAITA Experiments (CMIX) Project. The MDA wells provide the capability for a number of investigators to perform mixing and bioprocessing experiments in space. In the area of human adaptation to microgravity, a significant database has been obtained over the past three decades. Some low-g effects are similar to Earth-based disorders (anemia, osteoporosis, neuromuscular diseases, and immune system disorders). As new information targets potential profit-making processes, services and products from microgravity, commercial space ventures are expected to expand accordingly. Cooperative CCDS research in the above mentioned areas is essential for maturing SSF biotechnology and to ensure U.S. leadership in space technology

  17. Quarterly Progress Report for the Chemical and Energy Research Section of the Chemical Technology Division: July-September 1999

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jubin, R.T.

    2001-04-16

    This report summarizes the major activities conducted in the Chemical and Energy Research Section of the Chemical Technology Division at Oak Ridge National Laboratory (ORNL) during the period July-September 1999. The section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within ten major areas of research: Hot Cell Operations, Process Chemistry, Molten Salt Reactor Experiment (MSRE) Remediation Studies, Chemistry Research, Physical Properties Research, Biochemical Engineering, Separations and Materials Synthesis, Fluid Structures andmore » Properties, Biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information. Activities conducted within the area of the Cell Operations involved the testing of two continuously stirred tank reactors in series to evaluate the Savannah River-developed process of small-tank tetraphenylborate precipitation to remove cesium, strontium and transuranics from supernatant. Within the area of Process Chemistry, various topics related to solids formation in process solutions from caustic treatment of Hanford sludge were addressed. Saltcake dissolution efforts continued, including the development of a predictive algorithm. New initiatives for the section included modeling activities centered on detection of hydrogen in {sup 233}U storage wells and wax formation in petroleum mixtures, as well as support for the Spallation Neutron Source (investigation of transmutation products formed during operation). Other activities involved in situ grouting and evaluation of options for use (i.e., as castable shapes) of depleted uranium. In a continuation of activities of the

  18. Application of biodynamic imaging for personalized chemotherapy in canine lymphoma

    NASA Astrophysics Data System (ADS)

    Custead, Michelle R.

    Biodynamic imaging (BDI) is a novel phenotypic cancer profiling technology which characterizes changes in cellular and subcellular motion in living tumor tissue samples following in vitro or ex vivo treatment with chemotherapeutics. The ability of BDI to predict clinical response to single-agent doxorubicin chemotherapy was tested in ten dogs with naturally-occurring non-Hodgkin's lymphomas (NHL). Pre-treatment tumor biopsy samples were obtained from all dogs and treated with doxorubicin (10 muM) ex vivo. BDI captured cellular and subcellular motility measures on all biopsy samples at baseline and at regular intervals for 9 hours following drug application. All dogs subsequently received treatment with a standard single-agent doxorubicin protocol. Objective response (OR) to doxorubicin and progression-free survival time (PFST) following chemotherapy were recorded for all dogs. The dynamic biomarkers measured by BDI were entered into a multivariate logistic model to determine the extent to which BDI predicted OR and PFST following doxorubicin therapy. The model showed that the sensitivity, specificity, and accuracy of BDI for predicting treatment outcome were 95%, 91%, and 93%, respectively. To account for possible over-fitting of data to the predictive model, cross-validation with a one-left-out analysis was performed, and the adjusted sensitivity, specificity, and accuracy following this analysis were 93%, 87%, and 91%, respectively. These findings suggest that BDI can predict, with high accuracy, treatment outcome following single-agent doxorubicin chemotherapy in a relevant spontaneous canine cancer model, and is a promising novel technology for advancing personalized cancer medicine.

  19. Earth Sciences Division annual report 1990

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1991-06-01

    This Annual Report presents summaries of selected representative research activities grouped according to the principal disciplines of the Earth Sciences Division: Reservoir Engineering and Hydrogeology, Geology and Geochemistry, and Geophysics and Geomechanics. Much of the Division`s research deals with the physical and chemical properties and processes in the earth`s crust, from the partially saturated, low-temperature near-surface environment to the high-temperature environments characteristic of regions where magmatic-hydrothermal processes are active. Strengths in laboratory and field instrumentation, numerical modeling, and in situ measurement allow study of the transport of mass and heat through geologic media -- studies that now include the appropriatemore » chemical reactions and the hydraulic-mechanical complexities of fractured rock systems. Of particular note are three major Division efforts addressing problems in the discovery and recovery of petroleum, the application of isotope geochemistry to the study of geodynamic processes and earth history, and the development of borehole methods for high-resolution imaging of the subsurface using seismic and electromagnetic waves. In 1989 a major DOE-wide effort was launched in the areas of Environmental Restoration and Waste Management. Many of the methods previously developed for and applied to deeper regions of the earth will in the coming years be turned toward process definition and characterization of the very shallow subsurface, where man-induced contaminants now intrude and where remedial action is required.« less

  20. AICD -- Advanced Industrial Concepts Division Biological and Chemical Technologies Research Program. 1993 Annual summary report

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Petersen, G.; Bair, K.; Ross, J.

    1994-03-01

    The annual summary report presents the fiscal year (FY) 1993 research activities and accomplishments for the United States Department of Energy (DOE) Biological and Chemical Technologies Research (BCTR) Program of the Advanced Industrial Concepts Division (AICD). This AICD program resides within the Office of Industrial Technologies (OIT) of the Office of Energy Efficiency and Renewable Energy (EE). The annual summary report for 1993 (ASR 93) contains the following: A program description (including BCTR program mission statement, historical background, relevance, goals and objectives), program structure and organization, selected technical and programmatic highlights for 1993, detailed descriptions of individual projects, a listingmore » of program output, including a bibliography of published work, patents, and awards arising from work supported by BCTR.« less

  1. Website for the Space Science Division

    NASA Technical Reports Server (NTRS)

    Schilling, James; DeVincenzi, Donald (Technical Monitor)

    2002-01-01

    The Space Science Division at NASA Ames Research Center is dedicated to research in astrophysics, exobiology, advanced life support technologies, and planetary science. These research programs are structured around Astrobiology (the study of life in the universe and the chemical and physical forces and adaptions that influence life's origin, evolution, and destiny), and address some of the most fundamental questions pursued by science. These questions examine the origin of life and our place in the universe. Ames is recognized as a world leader in Astrobiology. In pursuing our mission in Astrobiology, Space Science Division scientists perform pioneering basic research and technology development.

  2. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of complete EHS0470, General Employee Radiation Safety (on-line course). Escort is required for visitors who Safety (on-line course) ii. EHS0348 Chemical Hygiene and Safety (on-line course) iii. EHS0470 General

  3. Analytical Chemistry Division annual progress report for period ending December 31, 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    The Analytical Chemistry Division of Oak Ridge National Laboratory (ORNL) is a large and diversified organization. As such, it serves a multitude of functions for a clientele that exists both in and outside of ORNL. These functions fall into the following general categories: (1) Analytical Research, Development, and Implementation. The division maintains a program to conceptualize, investigate, develop, assess, improve, and implement advanced technology for chemical and physicochemical measurements. Emphasis is on problems and needs identified with ORNL and Department of Energy (DOE) programs; however, attention is also given to advancing the analytical sciences themselves. (2) Programmatic Research, Development, andmore » Utilization. The division carries out a wide variety of chemical work that typically involves analytical research and/or development plus the utilization of analytical capabilities to expedite programmatic interests. (3) Technical Support. The division performs chemical and physicochemical analyses of virtually all types. The Analytical Chemistry Division is organized into four major sections, each of which may carry out any of the three types of work mentioned above. Chapters 1 through 4 of this report highlight progress within the four sections during the period January 1 to December 31, 1988. A brief discussion of the division's role in an especially important environmental program is given in Chapter 5. Information about quality assurance, safety, and training programs is presented in Chapter 6, along with a tabulation of analyses rendered. Publications, oral presentations, professional activities, educational programs, and seminars are cited in Chapters 7 and 8.« less

  4. Biodynamic response at the palm of the human hand subjected to a random vibration.

    PubMed

    Dong, Ren G; McDowell, Thomas W; Welcome, Daniel E

    2005-01-01

    This study investigated the biodynamic response (BR) distributed at the palm of the hand subjected to a random vibration. Twelve male subjects were used in the experiment. Each subject applied three coupling actions (grip-only, push-only, and combined grip and push) on a simulated tool handle at three different levels (50, 75, and 100 N) of palm force. This study found that the hand-arm system resonated mostly in the frequency range of 20 to 50 Hz, depending on the specific test treatment and individual characteristics. The maximum vibration power transmission through the palm occurred at the resonant frequency. Increasing the effective palm force generally increased the BR magnitude and resonant frequency. The apparent stiffness measured at the middle frequencies (80-100 Hz) is correlated to the BR in almost the entire frequency range (20-1,000 Hz). Under the same palm force, the push-only action corresponded to the highest BR values while the grip-only action generally produced the lowest values. Since the resonant frequency range matches the dominant vibration frequency range of many percussive tools, it is anticipated that the palm BR and vibration power transmission may have an association with vibration-induced injuries or disorders in the wrist-arm system among the workers using these tools.

  5. U.S. Army Chemical Corps Historical Studies, Gas Warfare in World War I: The 5th Division Captures Frapelle, August 1918

    DTIC Science & Technology

    1958-03-01

    U. S . ARMY CHEMICAL CORPS HISTORICAL STUDIES GAS WARFARE IN WORLD WAR I THE 5t1h DIVISION CAPTURES FRAPELLF, 00 August 1918 CTD Offce t e Chef Ch mal...j JNSPECrrr / D~iJ f ; t t] GA o WARFARE IN WORLD WAR I By - --------- St ixdy Number 7 t:a . • ’ I : : . .. s U.S. ARMY CHEIICAL CORPS [ist...Analysi s Concerning the Weight of Shell . . . . . . . ... . 38 The Cost of Frapelle . . . . . . . . . . . .. 41 Medical Department Comments

  6. The Position and Mobility of the Shoulder, Spinal Column and Pelvis in Seated Subjects.

    DTIC Science & Technology

    1985-02-01

    Wright-Patterson AFB acted as contract monitor; and Ints Kaleps, * Ph.D., Chief, Modeling and Analysis Branch, Biodynamics and Bioengineering Division...lumbar flexion and luibar extension motion series. Fewer motion segments are available for shoulder abduction motion analysis . These data are reported in...the measurements of this cadaver, samples of muscle and tendon were examined histologically to 12 attachments to trolley and arm cuff so that it

  7. Simulation of Thrust-Vectored Aircraft Maneuvers on a Human Centrifuge: Model Validation and Design for the Dynamic Environment Simulator

    DTIC Science & Technology

    1998-09-01

    reviewed and is approved for publication. FOR THE DIRECTOR ROGER L. STORK , Colonel, USAF, BSC Chief, Biodynamics and Protection Division Air Force Research...possible disorienting stimuli. Short radius yaw rotational movements that occur in helicopter flight and vertical take off and landing (VTOL) fixed wing ... wing flight. Aeronautical terms and thought has evolved. Tactical concepts, once thought inviolate, are changing. New terms are emerging and the very

  8. 41. JL photographer, summer 1978, view of chemical mixer from ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    41. JL photographer, summer 1978, view of chemical mixer from atop chemical spray nozzels. - Division Avenue Pumping Station & Filtration Plant, West 45th Street and Division Avenue, Cleveland, Cuyahoga County, OH

  9. Modeling of biodynamic responses distributed at the fingers and the palm of the human hand-arm system.

    PubMed

    Dong, Ren G; Dong, Jennie H; Wu, John Z; Rakheja, Subhash

    2007-01-01

    The objective of this study is to develop analytical models for simulating driving-point biodynamic responses distributed at the fingers and palm of the hand under vibration along the forearm direction (z(h)-axis). Two different clamp-like model structures are formulated to analyze the distributed responses at the fingers-handle and palm-handle interfaces, as opposed to the single driving point invariably considered in the reported models. The parameters of the proposed four- and five degrees-of-freedom models are identified through minimization of an rms error function of the model and measured responses under different hand actions, namely, fingers pull, push only, grip only, and combined push and grip. The results show that the responses predicted from both models agree reasonably well with the measured data in terms of distributed as well total impedance magnitude and phase. The variations in the identified model parameters under different hand actions are further discussed in view of the biological system behavior. The proposed models are considered to serve as useful tools for design and assessment of vibration isolation methods, and for developing a hand-arm simulator for vibration analysis of power tools.

  10. Harold Seifried, PhD | Division of Cancer Prevention

    Cancer.gov

    Dr. Harold Seifried is a member of the American Chemical Society Biological Chemistry Division; American College of Toxicology Industrial Toxicology Subcommittee; American Industrial Hygiene Association; Society of Toxicology; International Society for the Study of Xenobiotics; Diplomate of the American Board of Toxicology since 1980; American Board of Industrial Hygiene,

  11. Evaluation on subcellular partitioning and biodynamics of pulse copper toxicity in tilapia reveals impacts of a major environmental disturbance.

    PubMed

    Ju, Yun-Ru; Yang, Ying-Fei; Tsai, Jeng-Wei; Cheng, Yi-Hsien; Chen, Wei-Yu; Liao, Chung-Min

    2017-07-01

    Fluctuation exposure of trace metal copper (Cu) is ubiquitous in aquatic environments. The purpose of this study was to investigate the impacts of chronically pulsed exposure on biodynamics and subcellular partitioning of Cu in freshwater tilapia (Oreochromis mossambicus). Long-term 28-day pulsed Cu exposure experiments were performed to explore subcellular partitioning and toxicokinetics/toxicodynamics of Cu in tilapia. Subcellular partitioning linking with a metal influx scheme was used to estimate detoxification and elimination rates. A biotic ligand model-based damage assessment model was used to take into account environmental effects and biological mechanisms of Cu toxicity. We demonstrated that the probability causing 50% of susceptibility risk in response to pulse Cu exposure in generic Taiwan aquaculture ponds was ~33% of Cu in adverse physiologically associated, metabolically active pool, implicating no significant susceptibility risk for tilapia. We suggest that our integrated ecotoxicological models linking chronic exposure measurements with subcellular partitioning can facilitate a risk assessment framework that provides a predictive tool for preventive susceptibility reduction strategies for freshwater fish exposed to pulse metal stressors.

  12. Publications - GMC 1 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Surveys Home Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications GMC 1 main content Itkillik #1 well Authors: Amerada Hess Corporation, and Chemical and Geological Laboratories of Alaska

  13. 49 CFR 177.841 - Division 6.1 and Division 2.3 materials.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Division 6.1 and Division 2.3 materials. 177.841... PUBLIC HIGHWAY Loading and Unloading § 177.841 Division 6.1 and Division 2.3 materials. (See also § 177...) or Division 6.1 (poisonous) materials. The transportation of a Division 2.3 (poisonous gas) or...

  14. Summaries of FY 1979 research in the chemical sciences

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1980-05-01

    The purpose of this report is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. Chemists, physicists, chemical engineers and others who are considering the possibility of proposing research for support by this Division wll find the booklet useful for gauging the scope of the program in basic research, and the relationship of their interests to the overall program. These smmaries are intended to provide a rapid means for becoming acquainted with the Chemicalmore » Sciences program for members of the scientific and technological public, and interested persons in the Legislative and Executive Branches of the Government, in order to indicate the areas of research supported by the Division and energy technologies which may be advanced by use of basic knowledge discovered in this program. Scientific excellence is a major criterion applied in the selection of research supported by Chemical Sciences. Another important consideration is the identifying of chemical, physical and chemical engineering subdisciplines which are advancing in ways which produce new information related to energy, needed data, or new ideas.« less

  15. 33 CFR 274.6 - Division/district pest control programs.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ..., DEPARTMENT OF DEFENSE PEST CONTROL PROGRAM FOR CIVIL WORKS PROJECTS Project Operation § 274.6 Division... from time to time, will be used as guides in selecting the type of chemicals and the method of application in the control of vegetation and pests at civil works projects. (b) Responsibilities and reports...

  16. Summaries of FY 1982 research in the chemical sciences

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1982-09-01

    The purpose of this booklet is to help those interested in research supported by the Department of Energy's Division of Chemical Sciences, which is one of six Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries are intended to provide a rapid means for becoming acquainted with the Chemical Sciences program to members of the scientific and technological public and interested persons in the Legislative and Executive Branches of the Government. Areas of research supported by the Division are to be seen in the section headings, the index and the summaries themselves. Energymore » technologies which may be advanced by use of the basic knowledge discovered in this program can be seen in the index and again (by reference) in the summaries. The table of contents lists the following: photochemical and radiation sciences; chemical physics; atomic physics; chemical energy; separation and analysis; chemical engineering sciences; offsite contracts; equipment funds; special facilities; topical index; institutional index for offsite contracts; investigator index.« less

  17. To Predict the Body’s Strength

    DTIC Science & Technology

    1988-11-01

    requests to Henning E. Von Gierke, Dr. Eng., T"rector, Biodynamics & Bioengineering Division, Wright-Patterson Fig. 1. The anatomy of the human neck ...aircraft emerged. This idea generated the 0 8.O- 0 question, "How much acceleration in the buttocks- 4 0 to- head direction is tolerable in ejecting a...determine that the required 10-12 G head - 0 . JJwards acceleration would be tolerable for I second (21). 01O c 0 0And that was the criteria for the first

  18. Autonomous model protocell division driven by molecular replication.

    PubMed

    Taylor, J W; Eghtesadi, S A; Points, L J; Liu, T; Cronin, L

    2017-08-10

    The coupling of compartmentalisation with molecular replication is thought to be crucial for the emergence of the first evolvable chemical systems. Minimal artificial replicators have been designed based on molecular recognition, inspired by the template copying of DNA, but none yet have been coupled to compartmentalisation. Here, we present an oil-in-water droplet system comprising an amphiphilic imine dissolved in chloroform that catalyses its own formation by bringing together a hydrophilic and a hydrophobic precursor, which leads to repeated droplet division. We demonstrate that the presence of the amphiphilic replicator, by lowering the interfacial tension between droplets of the reaction mixture and the aqueous phase, causes them to divide. Periodic sampling by a droplet-robot demonstrates that the extent of fission is increased as the reaction progresses, producing more compartments with increased self-replication. This bridges a divide, showing how replication at the molecular level can be used to drive macroscale droplet fission.Coupling compartmentalisation and molecular replication is essential for the development of evolving chemical systems. Here the authors show an oil-in-water droplet containing a self-replicating amphiphilic imine that can undergo repeated droplet division.

  19. Chemical Technology Division annual technical report, 1992

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Battles, J.E.; Myles, K.M.; Laidler, J.J.

    1993-06-01

    In this period, CMT conducted research and development in the following areas: (1) electrochemical technology, including advanced batteries and fuel cells; (2) technology for fluidized-bed combustion and coal-fired magnetohydrodynamics; (3) methods for treatment of hazardous waste, mixed hazardous/radioactive waste, and municipal solid waste; (4) the reaction of nuclear waste glass and spent fuel under conditions expected for an unsaturated repository; (5) processes for separating and recovering transuranic elements from nuclear waste streams, treating water contaminated with volatile organics, and concentrating radioactive waste streams; (6) recovery processes for discharged fuel and the uranium blanket in the Integral Fast Reactor (EFR); (7)more » processes for removal of actinides in spent fuel from commercial water-cooled nuclear reactors and burnup in IFRs; and (8) physical chemistry of selected materials (corium; Fe-U-Zr, tritium in LiAlO{sub 2} in environments simulating those of fission and fusion energy systems. The Division also conducts basic research in catalytic chemistry associated with molecular energy resources and novel` ceramic precursors; materials chemistry of superconducting oxides, electrified metal/solution interfaces, and molecular sieve structures; and the geochemical processes involved in water-rock interactions occurring in active hydrothermal systems. In addition, the Analytical Chemistry Laboratory in CMT provides a broad range of analytical chemistry support services to the technical programs at Argonne National Laboratory (ANL).« less

  20. Health physics division annual progress report for period ending June 30, 1977

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1978-07-01

    This annual progress report follows, as in the past, the organizational structure of the Health Physics Division. Each part is a report of work done by a section of the division: Assessment and Technology Section (Part I), headed by H.W. Dickson; Biological and Radiation Physics Section (Part II), H.A. Wright; Chemical Physics and Spectroscopy Section (Part III), W.R. Garrett; Emergency Technology Section (Part IV), C.V. Chester, Medical Physics and Internal Dosimetry Section (Part V), K.E. Cowser; and the Analytic Dosimetry and Education Group (Part VI), J.E. Turner.

  1. Organic Addict. And Why Not?

    ERIC Educational Resources Information Center

    Pilliaud, Denis

    1993-01-01

    Discusses the practice of organic farming as used in Japan. Defines the biodynamic agricultural method based on the principle of the dynamics that control life on earth from the cosmos. Argues that organic farming does not benefit from chemicals used on neighboring farms. (MDH)

  2. Multiple-division of self-propelled oil droplets through acetal formation.

    PubMed

    Banno, Taisuke; Kuroha, Rie; Miura, Shingo; Toyota, Taro

    2015-02-28

    We demonstrate a novel system that exhibits both self-propelled motion and division of micrometer-sized oil droplets induced by chemical conversion of the system components. Such unique dynamics were observed in an oil-in-water emulsion of a benzaldehyde derivative, an alkanol and a cationic surfactant at a low pH.

  3. Jo Ann Rinaudo, PhD | Division of Cancer Prevention

    Cancer.gov

    Dr. Jo Ann Rinaudo is a Program Director in the Cancer Biomarkers Research Group in the Division of Cancer Prevention at the National Cancer Institute. She received a doctoral degree from the University of Toronto, where she studied chemical carcinogenesis in the liver. She was in the pathology department and has a broad background in human disease. Post-graduate training

  4. Lipid Cell Biology: A Focus on Lipids in Cell Division.

    PubMed

    Storck, Elisabeth M; Özbalci, Cagakan; Eggert, Ulrike S

    2018-06-20

    Cells depend on hugely diverse lipidomes for many functions. The actions and structural integrity of the plasma membrane and most organelles also critically depend on membranes and their lipid components. Despite the biological importance of lipids, our understanding of lipid engagement, especially the roles of lipid hydrophobic alkyl side chains, in key cellular processes is still developing. Emerging research has begun to dissect the importance of lipids in intricate events such as cell division. This review discusses how these structurally diverse biomolecules are spatially and temporally regulated during cell division, with a focus on cytokinesis. We analyze how lipids facilitate changes in cellular morphology during division and how they participate in key signaling events. We identify which cytokinesis proteins are associated with membranes, suggesting lipid interactions. More broadly, we highlight key unaddressed questions in lipid cell biology and techniques, including mass spectrometry, advanced imaging, and chemical biology, which will help us gain insights into the functional roles of lipids.

  5. Arabidopsis plants perform arithmetic division to prevent starvation at night

    PubMed Central

    Scialdone, Antonio; Mugford, Sam T; Feike, Doreen; Skeffington, Alastair; Borrill, Philippa; Graf, Alexander; Smith, Alison M; Howard, Martin

    2013-01-01

    Photosynthetic starch reserves that accumulate in Arabidopsis leaves during the day decrease approximately linearly with time at night to support metabolism and growth. We find that the rate of decrease is adjusted to accommodate variation in the time of onset of darkness and starch content, such that reserves last almost precisely until dawn. Generation of these dynamics therefore requires an arithmetic division computation between the starch content and expected time to dawn. We introduce two novel chemical kinetic models capable of implementing analog arithmetic division. Predictions from the models are successfully tested in plants perturbed by a night-time light period or by mutations in starch degradation pathways. Our experiments indicate which components of the starch degradation apparatus may be important for appropriate arithmetic division. Our results are potentially relevant for any biological system dependent on a food reserve for survival over a predictable time period. DOI: http://dx.doi.org/10.7554/eLife.00669.001 PMID:23805380

  6. Materials and Chemical Sciences Division annual report, 1987

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1988-07-01

    Research programs from Lawrence Berkeley Laboratory in materials science, chemical science, nuclear science, fossil energy, energy storage, health and environmental sciences, program development funds, and work for others is briefly described. (CBS)

  7. Biology Division progress report for period of October 1, 1988--September 30, 1989

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1990-02-01

    The Biology Division of the Oak Ridge National Laboratory is one component of the Department of Energy's intramural program in life sciences. With respect to experimental biology, the congressionally mandated mission of this Office is to study adverse health effects of energy production and utilization. Within this stated broad mission, common themes among the research programs of the Biology Division are interactions of animals, cells, and molecules with their respective environments. Investigations focus on genetic and somatic effects of radiation and chemicals. Goals include identification and quantification of these effects, elucidation of pathways by which the effects are expressed, assessmentmore » of risks associated with radiation and chemical exposures, and establishment of strategies for extrapolation of risk data from animals to humans. Concurrent basic studies in genetics, biochemistry, molecular biology, and cell biology illuminate normal life processes as prerequisites to comprehending mutagenic and carcinogenic effects of environmental agents. This Progress Report is intended to provide both broad perspectives of the Division's research programs and synopses of recent achievements. Readers are invited to contact individual principal investigators for more detailed information, including reprints of publications. 120 refs.« less

  8. Energy and Environment Division annual report, 1978

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Camp, J.A.

    1978-01-01

    Research activities of this Division are reported under nine separate programs, namely: Energy Analysis; Solar Energy; Energy-Efficient Buildings; Chemical Process Research and Development; Environmental Research; Atmospheric Aerosol Research; Oil Shale Research; Instrumentation Development; and Combustion Research. A separate abstract was prepared for each of the nine programs, each of which contained several individual research summaries, with responsible researchers listed. All of the abstracts will appear in Energy Research Abstracts (ERA), and five will appear in Energy Abstracts for Policy Analysis (EAPA).

  9. Film processing investigation. [improved chemical mixing system

    NASA Technical Reports Server (NTRS)

    Kelly, J. L.

    1972-01-01

    The present operational chemical mixing system for the Photographic Technology Division is evaluated, and the limitations are defined in terms of meeting the present and programmed chemical supply and delivery requirements. A major redesign of the entire chemical mixing, storage, analysis, and supply system is recommended. Other requirements for immediate and future implementations are presented.

  10. Engineering physics and mathematics division

    NASA Astrophysics Data System (ADS)

    Sincovec, R. F.

    1995-07-01

    This report provides a record of the research activities of the Engineering Physics and Mathematics Division for the period 1 Jan. 1993 - 31 Dec. 1994. This report is the final archival record of the EPM Division. On 1 Oct. 1994, ORELA was transferred to Physics Division and on 1 Jan. 1995, the Engineering Physics and Mathematics Division and the Computer Applications Division reorganized to form the Computer Science and Mathematics Division and the Computational Physics and Engineering Division. Earlier reports in this series are identified on the previous pages, along with the progress reports describing ORNL's research in the mathematical sciences prior to 1984 when those activities moved into the Engineering Physics and Mathematics Division.

  11. Chemistry Division. Quarterly progress report for period ending June 30, 1949

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1949-09-14

    Progress reports are presented for the following tasks: (1) nuclear and chemical properties of heavy elements (solution chemistry, phase rule studies); (2) nuclear and chemical properties of elements in the fission product region; (3) general nuclear chemistry; (4) radio-organic chemistry; (5) chemistry of separations processes; (6) physical chemistry and chemical physics; (7) radiation chemistry; (8) physical measurements and instrumentation; and (9) analytical chemistry. The program of the chemistry division is divided into two efforts of approximately equal weight with respect to number of personnel, chemical research, and analytical service for the Laboratory. The various research problems fall into the followingmore » classifications: (1) chemical separation processes for isolation and recovery of fissionable material, production of radioisotopes, and military applications; (2) reactor development; and (3) fundamental research.« less

  12. 75 FR 16843 - Core Manufacturing, Multi-Plastics, Inc., Division, Sipco, Inc., Division, Including Leased...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-02

    ... Manufacturing, Multi-Plastics, Inc., Division, Sipco, Inc., Division, Including Leased Workers of M-Ploy... Manufacturing, Multi-Plastics, Inc., Division and Sipco, Inc., Division, including leased workers of M-Ploy... applicable to TA-W-70,457 is hereby issued as follows: ``All workers of Core Manufacturing, Multi-Plastics...

  13. Chemistry Division annual progress report for period ending April 30, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Poutsma, M.L.; Ferris, L.M.; Mesmer, R.E.

    1993-08-01

    The Chemistry Division conducts basic and applied chemical research on projects important to DOE`s missions in sciences, energy technologies, advanced materials, and waste management/environmental restoration; it also conducts complementary research for other sponsors. The research are arranged according to: coal chemistry, aqueous chemistry at high temperatures and pressures, geochemistry, chemistry of advanced inorganic materials, structure and dynamics of advanced polymeric materials, chemistry of transuranium elements and compounds, chemical and structural principles in solvent extraction, surface science related to heterogeneous catalysis, photolytic transformations of hazardous organics, DNA sequencing and mapping, and special topics.

  14. Cell Division Synchronization

    DTIC Science & Technology

    The report summarizes the progress in the design and construction of automatic equipment for synchronizing cell division in culture by periodic...Concurrent experiments in hypothermic synchronization of algal cell division are reported.

  15. The complexity of divisibility.

    PubMed

    Bausch, Johannes; Cubitt, Toby

    2016-09-01

    We address two sets of long-standing open questions in linear algebra and probability theory, from a computational complexity perspective: stochastic matrix divisibility, and divisibility and decomposability of probability distributions. We prove that finite divisibility of stochastic matrices is an NP-complete problem, and extend this result to nonnegative matrices, and completely-positive trace-preserving maps, i.e. the quantum analogue of stochastic matrices. We further prove a complexity hierarchy for the divisibility and decomposability of probability distributions, showing that finite distribution divisibility is in P, but decomposability is NP-hard. For the former, we give an explicit polynomial-time algorithm. All results on distributions extend to weak-membership formulations, proving that the complexity of these problems is robust to perturbations.

  16. Deconstructing Calculation Methods, Part 4: Division

    ERIC Educational Resources Information Center

    Thompson, Ian

    2008-01-01

    In the final article of a series of four, the author deconstructs the primary national strategy's approach to written division. The approach to division is divided into five stages: (1) mental division using partition; (2) short division of TU / U; (3) "expanded" method for HTU / U; (4) short division of HTU / U; and (5) long division.…

  17. Chemicals from coal - The Eastman experience. [Anhydride

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Larkins, T.H.

    1986-03-01

    Tennessee Eastman Company is a major producer of chemicals, fibers and plastics. It is located in Kingsport, Tennessee, headquarters for the Eastman Chemicals Division of Eastman Kodak Company. Eastman Companies employ a total of 12,250 people in Kingsport. Other domestic Eastman Chemicals Division plants are located in Texas, South Carolina, Arkansas and New York. The authors began to witness a flow of products from one of the most highly technical and sophisticated chemical processes in operation in the world. The Eastman ''Chemicals-from-Coal'' facility is not a sunfuel plant. To be sure, we are producing syngas from coal, but the syngasmore » is used to produce acetic anhydride. Acetic anhydride is very important to Eastman. This chemical intermediate eventually finds its way into such diverse products as aspirin, cigarette filters, tool handles, and photographic film. It also is used to make other chemical intermediates such as cellulose esters, anhydrides, triacetin, and acetate ester solvents, all of which have a variety of end uses. The chemicals-from-coal project had its inception in the late 1960's when Eastman stepped up its program of energy conservation and began a search for lower cost chemical feedstocks. Our concern started before the national concern caused by a ten-fold increase in petroleum prices during the past decade.« less

  18. 2000 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

    EPA Science Inventory

    The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD)produces and publishes highly specialized technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment resear...

  19. 1997 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

    EPA Science Inventory

    The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

  20. 1996 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

    EPA Science Inventory

    The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific articles relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The rese...

  1. 1998 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

    EPA Science Inventory

    The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

  2. 1999 JOURNAL ARTICLES FROM LRPCD (TREATMENT AND DESTRUCTION BRANCH, LAND REMEDIATION AND POLLUTION CONTROL DIVISION, NRMRL)

    EPA Science Inventory

    The Treatment and Destruction Branch (TDB) of NRMRL's Land Remediation and Pollution Control Division (LRPCD) produces and publishes highly technical and scientific documents relating to TDB's research. TDB conducts bioremediation and physical/chemical treatment research. The res...

  3. Research in the chemical sciences. Summaries of FY 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-09-01

    This summary book is published annually to provide information on research supported by the Department of Energy`s Division of Chemical Sciences, which is one of four Divisions of the Office of Basic Energy Sciences in the Office of Energy Research. These summaries provide the scientific and technical public, as well as the legislative and executive branches of the Government, information, either generally or in some depth, about the Chemical Sciences program. Scientists interested in proposing research for support will find the publication useful for gauging the scope of the present basic research program and it`s relationship to their interests. Proposalsmore » that expand this scope may also be considered or directed to more appropriate offices. The primary goal of the research summarized here is to add significantly to the knowledge base in which existing and future efficient and safe energy technologies can evolve. As a result, scientific excellence is a major criterion applied in the selection of research supported by the Division of Chemical Sciences, but another important consideration is emphasis on science that is advancing in ways that will produce new information related to energy.« less

  4. Biorepositories | Division of Cancer Prevention

    Cancer.gov

    Carefully collected and controlled high-quality human biospecimens, annotated with clinical data and properly consented for investigational use, are available through the Division of Cancer Prevention Biorepositories listed in the charts below. Biorepositories Managed by the Division of Cancer Prevention Biorepositories Supported by the Division of Cancer Prevention Related

  5. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Postdoc Forum Research Highlights Awards Publications Database Events Calendar Newsletter Archive People ; Finance Templates Travel One-Stop Investigators Division Staff Facilities and Centers Staff Jobs People Division, please use the links here. An outline of the Division structure is available at the Organization

  6. Division G Commission 35: Stellar Constitution

    NASA Astrophysics Data System (ADS)

    Limongi, Marco; Lattanzio, John C.; Charbonnel, Corinne; Dominguez, Inma; Isern, Jordi; Karakas, Amanda; Leitherer, Claus; Marconi, Marcella; Shaviv, Giora; van Loon, Jacco

    2016-04-01

    Commission 35 (C35), ``Stellar Constitution'', consists of members of the International Astronomical Union whose research spans many aspects of theoretical and observational stellar physics and it is mainly focused on the comprehension of the properties of stars, stellar populations and galaxies. The number of members of C35 increased progressively over the last ten years and currently C35 comprises about 400 members. C35 was part of Division IV (Stars) until 2014 and then became part of Division G (Stars and Stellar Physics), after the main IAU reorganisation in 2015. Four Working Groups have been created over the years under Division IV, initially, and Division G later: WG on Active B Stars, WG on Massive Stars, WG on Abundances in Red Giant and WG on Chemically Peculiar and Related Stars. In the last decade the Commission had 4 presidents, Wojciech Dziembowski (2003-2006), Francesca D'Antona (2006-2009), Corinne Charbonnel (2009-2012) and Marco Limongi (2012-2015), who were assisted by an Organizing Committee (OC), usually composed of about 10 members, all of them elected by the C35 members and holding their positions for three years. The C35 webpage (http://iau-c35.stsci.edu) has been designed and continuously maintained by Claus Leitherer from the Space Telescope Institute, who deserves our special thanks. In addition to the various general information on the Commission structure and activities, it contains links to various resources, of interest for the members, such as stellar models, evolutionary tracks and isochrones, synthetic stellar populations, stellar yields and input physics (equation of state, nuclear cross sections, opacity tables), provided by various groups. The main activity of the C35 OC is that of evaluating, ranking and eventually supporting the proposals for IAU sponsored meetings. In the last decade the Commission has supported several meetings focused on topics more or less relevant to C35. Since the primary aim of this document is to

  7. 49 CFR 175.630 - Special requirements for Division 6.1 (poisonous) material and Division 6.2 (infectious...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Special requirements for Division 6.1 (poisonous) material and Division 6.2 (infectious substances) materials. 175.630 Section 175.630 Transportation Other... Classification of Material § 175.630 Special requirements for Division 6.1 (poisonous) material and Division 6.2...

  8. Division Quilts: A Measurement Model

    ERIC Educational Resources Information Center

    Pratt, Sarah S.; Lupton, Tina M.; Richardson, Kerri

    2015-01-01

    As teachers seek activities to assist students in understanding division as more than just the algorithm, they find many examples of division as fair sharing. However, teachers have few activities to engage students in a quotative (measurement) model of division. Efraim Fischbein and his colleagues (1985) defined two types of whole-number…

  9. From the Beginning: The "Journal of Chemical Education" and Secondary School Chemistry

    ERIC Educational Resources Information Center

    Lagowski, Joseph J.

    2014-01-01

    The people, events, and issues that were involved in the beginning and the evolution of the "Journal of Chemical Education" and the Division of Chemical Education (DivCHED) are traced and discussed. The constitution of the American Chemical Society incorporates the roots of chemical education as an area of interest to the Society. Both…

  10. Comparison of Concussion Rates Between NCAA Division I and Division III Men's and Women's Ice Hockey Players.

    PubMed

    Rosene, John M; Raksnis, Bryan; Silva, Brie; Woefel, Tyler; Visich, Paul S; Dompier, Thomas P; Kerr, Zachary Y

    2017-09-01

    Examinations related to divisional differences in the incidence of sports-related concussions (SRC) in collegiate ice hockey are limited. To compare the epidemiologic patterns of concussion in National Collegiate Athletic Association (NCAA) ice hockey by sex and division. Descriptive epidemiology study. A convenience sample of men's and women's ice hockey teams in Divisions I and III provided SRC data via the NCAA Injury Surveillance Program during the 2009-2010 to 2014-2015 academic years. Concussion counts, rates, and distributions were examined by factors including injury activity and position. Injury rate ratios (IRRs) and injury proportion ratios (IPRs) with 95% confidence intervals (CIs) were used to compare concussion rates and distributions, respectively. Overall, 415 concussions were reported for men's and women's ice hockey combined. The highest concussion rate was found in Division I men (0.83 per 1000 athlete-exposures [AEs]), followed by Division III women (0.78/1000 AEs), Division I women (0.65/1000 AEs), and Division III men (0.64/1000 AEs). However, the only significant IRR was that the concussion rate was higher in Division I men than Division III men (IRR = 1.29; 95% CI, 1.02-1.65). The proportion of concussions from checking was higher in men than women (28.5% vs 9.4%; IPR = 3.02; 95% CI, 1.63-5.59); however, this proportion was higher in Division I women than Division III women (18.4% vs 1.8%; IPR = 10.47; 95% CI, 1.37-79.75). The proportion of concussions sustained by goalkeepers was higher in women than men (14.2% vs 2.9%; IPR = 4.86; 95% CI, 2.19-10.77), with findings consistent within each division. Concussion rates did not vary by sex but differed by division among men. Checking-related concussions were less common in women than men overall but more common in Division I women than Division III women. Findings highlight the need to better understand the reasons underlying divisional differences within men's and women's ice hockey and the

  11. Soil microbiota respond to green manure in organic vineyards.

    PubMed

    Longa, C M O; Nicola, L; Antonielli, L; Mescalchin, E; Zanzotti, R; Turco, E; Pertot, I

    2017-12-01

    The aim of this work was to investigate the effects of biodynamic management with and without the addition of green manure, in comparison with organic management, on the microbiota in vineyards soil. High throughput sequencing was used to compare the taxonomic structure of the soil bacterial and fungal communities from vineyards managed with different methods (organic, biodynamic or biodynamic with green manure). Our results showed that microbial communities associated with biodynamic and organic farming systems were very similar, while green manure was the greatest source of soil microbial biodiversity and significantly changed microbial richness and community composition compared with other soils. Green manure also significantly enriched bacterial taxa involved in the soil nitrogen cycle (e.g. Microvirga sp., Pontibacter sp. and Nitrospira sp.). Our results showed that the diversity and composition of the microbial communities associated with biodynamic and organic farming systems were similar, indicating that the use of biodynamic preparations 500 and 501 did not cause any significant detectable changes to the soil microbial community in the short term, while the effects of green manure were significant in soil microbiota. The microbiological richness and structure of soil are used as a sensitive indicator of soil quality. The extension of organic/biodynamic farming, associated with green manure application, could contribute to increase the abundance of functional groups of biological and agronomical relevance and maintaining microbial biodiversity in vineyard soils. © 2017 The Society for Applied Microbiology.

  12. Solid State Division progress report for period ending September 30, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Green, P.H.; Hinton, L.W.

    1994-08-01

    This report covers research progress in the Solid State Division from April 1, 1992, to September 30, 1993. During this period, the division conducted a broad, interdisciplinary materials research program with emphasis on theoretical solid state physics, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. This research effort was enhanced by new capabilities in atomic-scale materials characterization, new emphasis on the synthesis and processing of materials, and increased partnering with industry and universities. The theoretical effort included a broad range of analytical studies, as well as a new emphasismore » on numerical simulation stimulated by advances in high-performance computing and by strong interest in related division experimental programs. Superconductivity research continued to advance on a broad front from fundamental mechanisms of high-temperature superconductivity to the development of new materials and processing techniques. The Neutron Scattering Program was characterized by a strong scientific user program and growing diversity represented by new initiatives in complex fluids and residual stress. The national emphasis on materials synthesis and processing was mirrored in division research programs in thin-film processing, surface modification, and crystal growth. Research on advanced processing techniques such as laser ablation, ion implantation, and plasma processing was complemented by strong programs in the characterization of materials and surfaces including ultrahigh resolution scanning transmission electron microscopy, atomic-resolution chemical analysis, synchrotron x-ray research, and scanning tunneling microscopy.« less

  13. Polarized Cell Division of Chlamydia trachomatis

    PubMed Central

    Abdelrahman, Yasser; Ouellette, Scot P.; Belland, Robert J.; Cox, John V.

    2016-01-01

    Bacterial cell division predominantly occurs by a highly conserved process, termed binary fission, that requires the bacterial homologue of tubulin, FtsZ. Other mechanisms of bacterial cell division that are independent of FtsZ are rare. Although the obligate intracellular human pathogen Chlamydia trachomatis, the leading bacterial cause of sexually transmitted infections and trachoma, lacks FtsZ, it has been assumed to divide by binary fission. We show here that Chlamydia divides by a polarized cell division process similar to the budding process of a subset of the Planctomycetes that also lack FtsZ. Prior to cell division, the major outer-membrane protein of Chlamydia is restricted to one pole of the cell, and the nascent daughter cell emerges from this pole by an asymmetric expansion of the membrane. Components of the chlamydial cell division machinery accumulate at the site of polar growth prior to the initiation of asymmetric membrane expansion and inhibitors that disrupt the polarity of C. trachomatis prevent cell division. The polarized cell division of C. trachomatis is the result of the unipolar growth and FtsZ-independent fission of this coccoid organism. This mechanism of cell division has not been documented in other human bacterial pathogens suggesting the potential for developing Chlamydia-specific therapeutic treatments. PMID:27505160

  14. Division of Environmental Health

    Science.gov Websites

    Environmental Conservation Alaska Department of Environmental Conservation Division of Environmental Health Pesticides Applicator Certification & Training Product Registration Pesticide-Use Permits Factsheets & You are here: DEC / Division of Environmental Health All DEC offices will be closed to the public on

  15. Division of Forestry Information

    Science.gov Websites

    Natural Resources / Division of Forestry Division of Forestry Information Fire Information Links Menu Fire Home Fire Overview Burn Permits Current Fire Information Become an Alaskan Firewise Community Fire Department of Natural Resources - Public Information Center DNR Media Releases Public Information Center

  16. Quarterly progress report for the Chemical and Energy Research Section of the Chemical Technology Division, April--June 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Jubin, R.T.

    The Chemical and Energy Research Section conducts basic and applied research and development in chemical engineering, applied chemistry, and bioprocessing, with an emphasis on energy-driven technologies and advanced chemical separations for nuclear and waste applications. The report describes the various tasks performed within six major areas of research: Hot Cell Operations, Process Chemistry and thermodynamics, Separations and Materials Synthesis, Solution Thermodynamics, biotechnology Research, and Molecular Studies. The name of a technical contact is included with each task described, and readers are encouraged to contact these individuals if they need additional information.

  17. 49 CFR 173.244 - Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3...

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 49 Transportation 2 2014-10-01 2014-10-01 false Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards...), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards (Division 6.1...

  18. 49 CFR 173.244 - Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards...), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards (Division 6.1...

  19. 49 CFR 173.244 - Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3...

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 49 Transportation 2 2013-10-01 2013-10-01 false Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards...), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards (Division 6.1...

  20. 49 CFR 173.244 - Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3...

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 49 Transportation 2 2012-10-01 2012-10-01 false Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards...), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards (Division 6.1...

  1. 49 CFR 173.244 - Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Bulk packaging for certain pyrophoric liquids (Division 4.2), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards...), dangerous when wet (Division 4.3) materials, and poisonous liquids with inhalation hazards (Division 6.1...

  2. Novel division level bacterial diversity in a Yellowstone hot spring.

    PubMed

    Hugenholtz, P; Pitulle, C; Hershberger, K L; Pace, N R

    1998-01-01

    A culture-independent molecular phylogenetic survey was carried out for the bacterial community in Obsidian Pool (OP), a Yellowstone National Park hot spring previously shown to contain remarkable archaeal diversity (S. M. Barns, R. E. Fundyga, M. W. Jeffries, and N. R. Page, Proc. Natl. Acad. Sci. USA 91:1609-1613, 1994). Small-subunit rRNA genes (rDNA) were amplified directly from OP sediment DNA by PCR with universally conserved or Bacteria-specific rDNA primers and cloned. Unique rDNA types among > 300 clones were identified by restriction fragment length polymorphism, and 122 representative rDNA sequences were determined. These were found to represent 54 distinct bacterial sequence types or clusters (> or = 98% identity) of sequences. A majority (70%) of the sequence types were affiliated with 14 previously recognized bacterial divisions (main phyla; kingdoms); 30% were unaffiliated with recognized bacterial divisions. The unaffiliated sequence types (represented by 38 sequences) nominally comprise 12 novel, division level lineages termed candidate divisions. Several OP sequences were nearly identical to those of cultivated chemolithotrophic thermophiles, including the hydrogen-oxidizing Calderobacterium and the sulfate reducers Thermodesulfovibrio and Thermodesulfobacterium, or belonged to monophyletic assemblages recognized for a particular type of metabolism, such as the hydrogen-oxidizing Aquificales and the sulfate-reducing delta-Proteobacteria. The occurrence of such organisms is consistent with the chemical composition of OP (high in reduced iron and sulfur) and suggests a lithotrophic base for primary productivity in this hot spring, through hydrogen oxidation and sulfate reduction. Unexpectedly, no archaeal sequences were encountered in OP clone libraries made with universal primers. Hybridization analysis of amplified OP DNA with domain-specific probes confirmed that the analyzed community rDNA from OP sediment was predominantly bacterial. These

  3. 49 CFR 1242.03 - Made by accounting divisions.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 9 2010-10-01 2010-10-01 false Made by accounting divisions. 1242.03 Section 1242... accounting divisions. The separation shall be made by accounting divisions, where such divisions are maintained, and the aggregate of the accounting divisions reported for the quarter and for the year. ...

  4. HUMAN HEALTH IMPACT OF ENVIRONMENTAL ESTROGENIC CHEMICALS

    EPA Science Inventory

    HUMAN HEALTH IMPACT OF ENVIRONMENTAL ESTROGENIC CHEMICALS.

    Robert J. Kavlock, Reproductive Toxicology Division, NHEERL, ORD, US Environmental Protection Agency, Research Triangle Park, NC USA.

    Over the past several decades a hypothesis has been put forth that a numb...

  5. 2017 T Division Lightning Talks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ramsey, Marilyn Leann; Abeywardhana, Jayalath AMM; Adams, Colin Mackenzie

    All members of the T Division Community, students, staff members, group leaders, division management, and other interested individuals are invited to come and support the following student(s) as they present their Lightning Talks.

  6. Division: The Sleeping Dragon

    ERIC Educational Resources Information Center

    Watson, Anne

    2012-01-01

    Of the four mathematical operators, division seems to not sit easily for many learners. Division is often described as "the odd one out". Pupils develop coping strategies that enable them to "get away with it". So, problems, misunderstandings, and misconceptions go unresolved perhaps for a lifetime. Why is this? Is it a case of "out of sight out…

  7. Fostering Remainder Understanding in Fraction Division

    ERIC Educational Resources Information Center

    Zembat, Ismail O.

    2017-01-01

    Most students can follow this simple procedure for division of fractions: "Ours is not to reason why, just invert and multiply." But how many really understand what division of fractions means--especially fraction division with respect to the meaning of the remainder. The purpose of this article is to provide an instructional method as a…

  8. Environmental/chemical thesaurus

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shriner, C.R.; Dailey, N.S.; Jordan, A.C.

    The Environmental/Chemical Thesaurus approaches scientific language control problems from a multidisciplinary view. The Environmental/Biomedical Terminology Index (EBTI) was used as a base for the present thesaurus. The Environmental/Chemical Thesaurus, funded by the Environmental Protection Agency, used as its source of new terms those major terms found in 13 Environmental Protection Agency data bases. The scope of this thesaurus includes not only environmental and biomedical sciences, but also the physical sciences with emphasis placed on chemistry. Specific chemical compounds are not included; only classes of chemicals are given. To adhere to this level of classification, drugs and pesticides are identified bymore » class rather than by specific chemical name. An attempt was also made to expand the areas of sociology and economics. Terminology dealing with law, demography, and geography was expanded. Proper names of languages and races were excluded. Geographic terms were expanded to include proper names for oceans, continents, major lakes, rivers, and islands. Political divisions were added to allow for proper names of countries and states. With such a broad scope, terminology for specific sciences does not provide for indexing to the lowest levels in plant, animal, or chemical classifications.« less

  9. 75 FR 1024 - Proposed Significant New Use Rules on Certain Chemical Substances; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-01-08

    ... information contact: Jim Alwood, Chemical Control Division (7405M), Office of Pollution Prevention and Toxics..., 2009. Barbara A. Cunningham, Acting Director, Office of Pollution Prevention and Toxics. [FR Doc. 2010...: Colby Lintner, Regulatory Coordinator, Environmental Assistance Division (7408M), Office of Pollution...

  10. Podcast: The Electronic Crimes Division

    EPA Pesticide Factsheets

    Sept 26, 2016. Chris Lukas, the Special Agent in Charge of the Electronic Crimes Division within the OIG's Office of Investigations talks about computer forensics, cybercrime in the EPA and his division's role in criminal investigations.

  11. 2016 T Division Lightning Talks

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ramsey, Marilyn Leann; Adams, Luke Clyde; Ferre, Gregoire Robing

    These are the slides for all of the 2016 T Division lightning talks. There are 350 pages worth of slides from different presentations, all of which cover different topics within the theoretical division at Los Alamos National Laboratory (LANL).

  12. Structures and Acoustics Division

    NASA Technical Reports Server (NTRS)

    Acquaviva, Cynthia S.

    1999-01-01

    The Structures and Acoustics Division of NASA Glenn Research Center is an international leader in rotating structures, mechanical components, fatigue and fracture, and structural aeroacoustics. Included are disciplines related to life prediction and reliability, nondestructive evaluation, and mechanical drive systems. Reported are a synopsis of the work and accomplishments reported by the Division during the 1996 calendar year. A bibliography containing 42 citations is provided.

  13. Lightning Talks 2015: Theoretical Division

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Shlachter, Jack S.

    2015-11-25

    This document is a compilation of slides from a number of student presentations given to LANL Theoretical Division members. The subjects cover the range of activities of the Division, including plasma physics, environmental issues, materials research, bacterial resistance to antibiotics, and computational methods.

  14. CHEMICAL ENGINEERING DIVISION SUMMARY REPORT, OCTOBER, NOVEMBER, DECEMBER 1960

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    None

    1961-03-01

    Chemical-metallurgical processing studies were made of pyrometallurgical development snd research, and fuel processing facilities for EBR-II. Fuel-cycle applications of fluidization and volatility techniques included laboratory investigations of fluoride volatility processes, engineeringscale development, and conversion of UF/sub 6/ to UO/sub 2/. Reactor safety studies consisted of metal oxidation and ignition kinetics, and metal-water reactions. Reactor chemistry investigations were conducted to determine nuclear constants and suitable reactor decontamination methods. Routine operations are summarized for the high-level gammairradiation facillty and waste processing. (B.O.G.)

  15. Chemical carcinogenesis: Too many rodent carcinogens

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ames, B.N.; Gold, L.S.

    1990-10-01

    The administration of chemicals at the maximum tolerated dose (MTD) in standard animal cancer tests is postulated to increase cell division (mitogenesis), which in turn increases rates of mutagenesis and thus carcinogenesis. The animal data are consistent with this mechanism, because a high proportion{endash}about half{endash}of all chemicals tested (whether natural or synthetic) are indeed rodent carcinogens. The authors conclude that at the low doses of most human exposures, where cell killing does not occur, the hazards to humans of rodent carcinogens may be much lower than is commonly assumed.

  16. [Chemical and biological evaluation of the effect of plant extracts against Plasmodium berghei].

    PubMed

    Castro, O; Barrios, M; Chinchilla, M; Guerrero, O

    1996-08-01

    Extracts from thirteen species of plants were evaluated by "in vivo" antimalarial test against plasmodium berghei effects. Significant activities were observed in the ethyl acetate and aqueous extracts, elaborated of Cedrela tonduzii leaves, Trichilia havanensis and Trichilia americana barks, Neurolaena lobata and Gliricidia sepium leaves and Duranta repens fruits. Compounds identified include flavanoids, coumarins, mellilotic acid and iridoids which some kind of biodynamic activity has previously been reported. The flavone quercetin 1 purified from C. tonduzii gave strong antimalarial activity, however, its respective glucosides (quercetin 3-glucoside 2 y robinine 7) showed little significant activity.

  17. Anticrossproducts and cross divisions.

    PubMed

    de Leva, Paolo

    2008-01-01

    This paper defines, in the context of conventional vector algebra, the concept of anticrossproduct and a family of simple operations called cross or vector divisions. It is impossible to solve for a or b the equation axb=c, where a and b are three-dimensional space vectors, and axb is their cross product. However, the problem becomes solvable if some "knowledge about the unknown" (a or b) is available, consisting of one of its components, or the angle it forms with the other operand of the cross product. Independently of the selected reference frame orientation, the known component of a may be parallel to b, or vice versa. The cross divisions provide a compact and insightful symbolic representation of a family of algorithms specifically designed to solve problems of such kind. A generalized algorithm was also defined, incorporating the rules for selecting the appropriate kind of cross division, based on the type of input data. Four examples of practical application were provided, including the computation of the point of application of a force and the angular velocity of a rigid body. The definition and geometrical interpretation of the cross divisions stemmed from the concept of anticrossproduct. The "anticrossproducts of axb" were defined as the infinitely many vectors x(i) such that x(i)xb=axb.

  18. Structures and Acoustics Division

    NASA Technical Reports Server (NTRS)

    Acquaviva, Cynthia S.

    2001-01-01

    The Structures and Acoustics Division of the NASA Glenn Research Center is an international leader in rotating structures, mechanical components, fatigue and fracture, and structural aeroacoustics. Included in this report are disciplines related to life prediction and reliability, nondestructive evaluation, and mechanical drive systems. Reported is a synopsis of the work and accomplishments completed by the Division during the 1997, 1998, and 1999 calendar years. A bibliography containing 93 citations is provided.

  19. Physics division annual report 2006.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Glover, J.; Physics

    2008-02-28

    This report highlights the activities of the Physics Division of Argonne National Laboratory in 2006. The Division's programs include the operation as a national user facility of ATLAS, the Argonne Tandem Linear Accelerator System, research in nuclear structure and reactions, nuclear astrophysics, nuclear theory, investigations in medium-energy nuclear physics as well as research and development in accelerator technology. The mission of nuclear physics is to understand the origin, evolution and structure of baryonic matter in the universe--the core of matter, the fuel of stars, and the basic constituent of life itself. The Division's research focuses on innovative new ways tomore » address this mission.« less

  20. Cell growth, division, and death in cohesive tissues: A thermodynamic approach

    NASA Astrophysics Data System (ADS)

    Yabunaka, Shunsuke; Marcq, Philippe

    2017-08-01

    Cell growth, division, and death are defining features of biological tissues that contribute to morphogenesis. In hydrodynamic descriptions of cohesive tissues, their occurrence implies a nonzero rate of variation of cell density. We show how linear nonequilibrium thermodynamics allows us to express this rate as a combination of relevant thermodynamic forces: chemical potential, velocity divergence, and activity. We illustrate the resulting effects of the nonconservation of cell density on simple examples inspired by recent experiments on cell monolayers, considering first the velocity of a spreading front, and second an instability leading to mechanical waves.

  1. 78 FR 66279 - Significant New Use Rules on Certain Chemical Substances; Removal of Significant New Use Rules

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-05

    ....gov or at the Office of Pollution Prevention and Toxics Docket (OPPT Docket), Environmental Protection... information contact: Kenneth Moss, Chemical Control Division (7405M), Office of Pollution Prevention and... Division, Office of Pollution Prevention and Toxics. Therefore, 40 CFR parts 9 and 721 are amended as...

  2. Fuel management in the Subtropical and Savanna divisions

    Treesearch

    Kenneth W. Outcalt

    2012-01-01

    The Subtropical Division (230) and Savanna Division (410), both based on Bailey’s (1996) ecoregions, are found in the Southern United States (http://www.na.fs.fed.us/fire/cwedocs/map%20new_divisions.pdf). The Subtropical Division occupies the southern Atlantic and Gulf coastal areas. It is characterized by a humid subtropical climate with hot humid summers (chapter 3...

  3. Concerted control of Escherichia coli cell division

    PubMed Central

    Osella, Matteo; Nugent, Eileen; Cosentino Lagomarsino, Marco

    2014-01-01

    The coordination of cell growth and division is a long-standing problem in biology. Focusing on Escherichia coli in steady growth, we quantify cell division control using a stochastic model, by inferring the division rate as a function of the observable parameters from large empirical datasets of dividing cells. We find that (i) cells have mechanisms to control their size, (ii) size control is effected by changes in the doubling time, rather than in the single-cell elongation rate, (iii) the division rate increases steeply with cell size for small cells, and saturates for larger cells. Importantly, (iv) the current size is not the only variable controlling cell division, but the time spent in the cell cycle appears to play a role, and (v) common tests of cell size control may fail when such concerted control is in place. Our analysis illustrates the mechanisms of cell division control in E. coli. The phenomenological framework presented is sufficiently general to be widely applicable and opens the way for rigorous tests of molecular cell-cycle models. PMID:24550446

  4. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of ? Click Here! Commitment to Safety at MSD In the Materials Sciences Division, our mission is to do world -class science in a safe environment. We proudly support a strong safety culture in which all staff and

  5. An examination of the stretching practices of Division I and Division III college football programs in the midwestern United States.

    PubMed

    Judge, Lawrence W; Craig, Bruce; Baudendistal, Steve; Bodey, Kimberly J

    2009-07-01

    Research supports the use of preactivity warm-up and stretching, and the purpose of this study was to determine whether college football programs follow these guidelines. Questionnaires designed to gather demographic, professional, and educational information, as well as specific pre- and postactivity practices, were distributed via e-mail to midwestern collegiate programs from NCAA Division I and III conferences. Twenty-three male coaches (12 from Division IA schools and 11 from Division III schools) participated in the study. Division I schools employed certified strength coaches (CSCS; 100%), whereas Division III schools used mainly strength coordinators (73%), with only 25% CSCS. All programs used preactivity warm-up, with the majority employing 2-5 minutes of sport-specific jogging/running drills. Pre stretching (5-10 minutes) was performed in 19 programs (91%), with 2 (9%) performing no pre stretching. Thirteen respondents used a combination of static/proprioceptive neuromuscular facilitation/ballistic and dynamic flexibility, 5 used only dynamic flexibility, and 1 used only static stretching. All 12 Division I coaches used stretching, whereas only 9 of the 11 Division III coaches did (p = 0.22). The results indicate that younger coaches did not use pre stretching (p = 0.30). The majority of the coaches indicated that they did use post stretching, with 11 of the 12 Division I coaches using stretching, whereas only 5 of the 11 Division III coaches used stretching postactivity (p = 0.027). Divisional results show that the majority of Division I coaches use static-style stretching (p = 0.049). The results of this study indicate that divisional status, age, and certification may influence how well research guidelines are followed. Further research is needed to delineate how these factors affect coaching decisions.

  6. Overview of the Applied Aerodynamics Division

    NASA Technical Reports Server (NTRS)

    1991-01-01

    A major reorganization of the Aeronautics Directorate of the Langley Research Center occurred in early 1989. As a result of this reorganization, the scope of research in the Applied Aeronautics Division is now quite different than that in the past. An overview of the current organization, mission, and facilities of this division is presented. A summary of current research programs and sample highlights of recent research are also presented. This is intended to provide a general view of the scope and capabilities of the division.

  7. Gravity and the orientation of cell division

    NASA Technical Reports Server (NTRS)

    Helmstetter, C. E.

    1997-01-01

    A novel culture system for mammalian cells was used to investigate division orientations in populations of Chinese hamster ovary cells and the influence of gravity on the positioning of division axes. The cells were tethered to adhesive sites, smaller in diameter than a newborn cell, distributed over a nonadhesive substrate positioned vertically. The cells grew and divided while attached to the sites, and the angles and directions of elongation during anaphase, projected in the vertical plane, were found to be random with respect to gravity. However, consecutive divisions of individual cells were generally along the same axis or at 90 degrees to the previous division, with equal probability. Thus, successive divisions were restricted to orthogonal planes, but the choice of plane appeared to be random, unlike the ordered sequence of cleavage orientations seen during early embryo development.

  8. Chemical Agent Detector Kits

    DTIC Science & Technology

    1989-04-28

    camera, and document test events and recorder procedures Thermometer +20C Psychrometer +5% 4 April 1989 TOP 8-2-555 Rough handling test and As specifie...not covered in AMC Regulation 385-131 will be performed iAW p oposals made by the Chemical Laboratory Division and approved by the Safety ¶ffice. 4.3...the packaged detector kit to higher and lower temperatures than it is expected to experience in actual packaged storage. Coordination should be made

  9. History of the Fluids Engineering Division

    DOE PAGES

    Cooper, Paul; Martin, C. Samuel; O'Hern, Timothy J.

    2016-08-03

    The 90th Anniversary of the Fluids Engineering Division (FED) of ASME will be celebrated on July 10–14, 2016 in Washington, DC. The venue is ASME's Summer Heat Transfer Conference (SHTC), Fluids Engineering Division Summer Meeting (FEDSM), and International Conference on Nanochannels and Microchannels (ICNMM). The occasion is an opportune time to celebrate and reflect on the origin of FED and its predecessor—the Hydraulic Division (HYD), which existed from 1926–1963. Furthermore, the FED Executive Committee decided that it would be appropriate to publish concurrently a history of the HYD/FED.

  10. History of the Fluids Engineering Division

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cooper, Paul; Martin, C. Samuel; O'Hern, Timothy J.

    The 90th Anniversary of the Fluids Engineering Division (FED) of ASME will be celebrated on July 10–14, 2016 in Washington, DC. The venue is ASME's Summer Heat Transfer Conference (SHTC), Fluids Engineering Division Summer Meeting (FEDSM), and International Conference on Nanochannels and Microchannels (ICNMM). The occasion is an opportune time to celebrate and reflect on the origin of FED and its predecessor—the Hydraulic Division (HYD), which existed from 1926–1963. Furthermore, the FED Executive Committee decided that it would be appropriate to publish concurrently a history of the HYD/FED.

  11. About DCP | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) is the division of the National Cancer Institute (NCI) devoted to cancer prevention research. DCP provides funding and administrative support to clinical and laboratory researchers, community and multidisciplinary teams, and collaborative scientific networks. |

  12. Adaptive magnetorheological seat suspension for shock mitigation

    NASA Astrophysics Data System (ADS)

    Singh, Harinder Jit

    This research focuses on theoretical and experimental analysis of an adaptive seat suspension employing magnetorheological energy absorber with the objective of minimizing injury potential to seated occupant of different weights subjected to broader crash intensities. The research was segmented into three tasks: (1) development of magnetorheological energy absorber, (2) biodynamic modeling of a seated occupant, and (3) control schemes for shock mitigation. A linear stroking semi-active magnetorheological energy absorber (MREA) was designed, fabricated and tested for intense impact conditions with piston velocities up to 8 m/s. MREA design was optimized on the basis of Bingham-plastic model (BPM model) in order to maximize the energy absorption capabilities at high impact velocities. Computational fluid dynamics and magnetic FE analysis were conducted to validate MREA performance. Subsequently, low-speed cyclic testing (0-2 Hz subjected to 0-5.5 A) and high-speed drop testing (0-4.5 m/s at 0 A) were conducted for quantitative comparison with the numerical simulations. Later, a nonlinear four degrees-of-freedom biodynamic model representing a seated 50th percentile male occupant was developed on the basis of experiments conducted on Hybrid II 50th percentile male anthropomorphic test device. The response of proposed biodynamic model was compared quantitatively against two different biodynamic models from the literature that are heavily implemented for obtaining biodynamic response under impact conditions. The proposed biodynamic model accurately predicts peak magnitude, overall shape and the duration of the biodynamic transient response, with minimal phase shift. The biodynamic model was further validated against 16 impact tests conducted on horizontal accelerator facility at NAVAIR for two different shock intensities. Compliance effects of human body were also investigated on the performance of adaptive seat suspension by comparing the proposed biodynamic model

  13. 78 FR 67141 - Antimony Trioxide (ATO) TSCA Chemical Risk Assessment; Notice of Public Meetings and Opportunity...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-11-08

    ... Chemical Risk Assessment; Notice of Public Meetings and Opportunity To Comment AGENCY: Environmental... Barone, Jr., Risk Assessment Division (7403M), Office of Pollution Prevention and Toxics, Environmental.... List of Subjects Environmental protection, ATO, Chemicals, Flame retardant synergist. Peer review, Risk...

  14. Molecular coordination of Staphylococcus aureus cell division

    PubMed Central

    Cotterell, Bryony E; Walther, Christa G; Fenn, Samuel J; Grein, Fabian; Wollman, Adam JM; Leake, Mark C; Olivier, Nicolas; Cadby, Ashley; Mesnage, Stéphane; Jones, Simon

    2018-01-01

    The bacterial cell wall is essential for viability, but despite its ability to withstand internal turgor must remain dynamic to permit growth and division. Peptidoglycan is the major cell wall structural polymer, whose synthesis requires multiple interacting components. The human pathogen Staphylococcus aureus is a prolate spheroid that divides in three orthogonal planes. Here, we have integrated cellular morphology during division with molecular level resolution imaging of peptidoglycan synthesis and the components responsible. Synthesis occurs across the developing septal surface in a diffuse pattern, a necessity of the observed septal geometry, that is matched by variegated division component distribution. Synthesis continues after septal annulus completion, where the core division component FtsZ remains. The novel molecular level information requires re-evaluation of the growth and division processes leading to a new conceptual model, whereby the cell cycle is expedited by a set of functionally connected but not regularly distributed components. PMID:29465397

  15. About Us | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    Division of Geological & Geophysical Surveys (DGGS) 3354 College Road, Fairbanks, AK 99709 Phone: (907 Division also administers the 11-member Alaska Seismic Hazards Safety Commission. Accomplishments The . Department of Natural Resources, Division of Geological & Geophysical Surveys (DGGS) 3354 College Road

  16. Chemically Initiated Electron-Exchange Luminescence.

    DTIC Science & Technology

    1980-11-14

    CONTROLLING OFFICE NAME AND ADDRESS IQ. REPORT DATE Chemistry Program, raterials Science Division, November 14, 1980 Office of Naval Research, 800 N. Quincy...A./IHorn Prepared for Publication in9 z Chemi- and Bio-Energized Processes School of Chemical Sciences University of Illinois Urbana, Illinois 61801...National Science Foundation and in part by the Office of Naval Research. GBS is a Fellow of the Alfred P. Sloan Foundation (1977-79) and The Dreyfus

  17. Cognitive and Neural Sciences Division 1991 Programs

    DTIC Science & Technology

    1991-08-01

    FUNDING NUMBERS Cognitive and Neural Sciences Division 1991 Programs PE 61153N 6. AUTHOR(S) Edited by Willard S. Vaughan 7. PERFORMING ORGANIZATION...NAME(S) AND ADDRESS(ES) 8. PERFORMING ORGANIZATION REPORT NUMBER Office of Naval Research 0CNR !1491-19 Cognitive and Neural Sciences Division Code 1142...NOTES iN This is a compilation of abstracts representing R&D sponsored by the ONR Cognitive and Neural Sciences Division. 12a. DISTRIBUTION

  18. Teaching Cell Division: Basics and Recommendations.

    ERIC Educational Resources Information Center

    Smith, Mike U.; Kindfield, Ann C. H.

    1999-01-01

    Presents a concise overview of cell division that includes only the essential concepts necessary for understanding genetics and evolution. Makes recommendations based on published research and teaching experiences that can be used to judge the merits of potential activities and materials for teaching cell division. Makes suggestions regarding the…

  19. Environmental Sciences Division annual progress report for period ending September 30, 1990

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1991-04-01

    The Environmental Sciences Division (ESD) of Oak Ridge National Laboratory (ORNL) conducts research on the environmental aspects of existing and emerging energy systems and applies this information to ensure that technology development and energy use are consistent with national environmental health and safety goals. Offering an interdisciplinary resource of staff and facilities to address complex environmental problems, the division is currently providing technical leadership for major environmental issues of national concern: (1) acidic deposition and related environmental effects, (2) effects of increasing concentrations of atmospheric CO{sub 2} and the resulting climatic changes to ecosystems and natural and physical resources, (3)more » hazardous chemical and radioactive waste disposal and remediation research and development, and (4) development of commercial biomass energy production systems. This progress report outlines ESD's accomplishments in these and other areas in FY 1990. Individual reports are processed separately for the data bases in the following areas: ecosystem studies; environmental analyses; environmental toxicology; geosciences; technical and administrative support; biofuels feedstock development program; carbon dioxide information analysis and research program; and environmental waste program.« less

  20. Exploring Divisibility and Summability of 'Photon' Wave Packets in Nonlinear Optical Phenomena

    NASA Technical Reports Server (NTRS)

    Prasad, Narasimha; Roychoudhuri, Chandrasekhar

    2009-01-01

    Formulations for second and higher harmonic frequency up and down conversions, as well as multi photon processes directly assume summability and divisibility of photons. Quantum mechanical (QM) interpretations are completely congruent with these assumptions. However, for linear optical phenomena (interference, diffraction, refraction, material dispersion, spectral dispersion, etc.), we have a profound dichotomy. Most optical engineers innovate and analyze all optical instruments by propagating pure classical electromagnetic (EM) fields using Maxwell s equations and gives only lip-service to the concept "indivisible light quanta". Further, irrespective of linearity or nonlinearity of the phenomena, the final results are always registered through some photo-electric or photo-chemical effects. This is mathematically well modeled by a quadratic action (energy absorption) relation. Since QM does not preclude divisibility or summability of photons in nonlinear & multi-photon effects, it cannot have any foundational reason against these same possibilities in linear optical phenomena. It implies that we must carefully revisit the fundamental roots behind all light-matter interaction processes and understand the common origin of "graininess" and "discreteness" of light energy.

  1. Reconciling Divisions in the Field of Authentic Education

    ERIC Educational Resources Information Center

    Sarid, Ariel

    2015-01-01

    The aim of this article is twofold: first, to identify and address three central divisions in the field of authentic education that introduce ambiguity and at times inconsistencies within the field of authentic education. These divisions concern a) the relationship between autonomy and authenticity; b) the division between the two basic attitudes…

  2. Chromosome segregation drives division site selection in Streptococcus pneumoniae.

    PubMed

    van Raaphorst, Renske; Kjos, Morten; Veening, Jan-Willem

    2017-07-18

    Accurate spatial and temporal positioning of the tubulin-like protein FtsZ is key for proper bacterial cell division. Streptococcus pneumoniae (pneumococcus) is an oval-shaped, symmetrically dividing opportunistic human pathogen lacking the canonical systems for division site control (nucleoid occlusion and the Min-system). Recently, the early division protein MapZ was identified and implicated in pneumococcal division site selection. We show that MapZ is important for proper division plane selection; thus, the question remains as to what drives pneumococcal division site selection. By mapping the cell cycle in detail, we show that directly after replication both chromosomal origin regions localize to the future cell division sites, before FtsZ. Interestingly, Z-ring formation occurs coincidently with initiation of DNA replication. Perturbing the longitudinal chromosomal organization by mutating the condensin SMC, by CRISPR/Cas9-mediated chromosome cutting, or by poisoning DNA decatenation resulted in mistiming of MapZ and FtsZ positioning and subsequent cell elongation. Together, we demonstrate an intimate relationship between DNA replication, chromosome segregation, and division site selection in the pneumococcus, providing a simple way to ensure equally sized daughter cells.

  3. 1. Oblique view of 215 Division Street, looking southwest, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    1. Oblique view of 215 Division Street, looking southwest, showing front (east) facade and north side, 213 Division Street is visible at left and 217 Division Street appears at right - 215 Division Street (House), Rome, Floyd County, GA

  4. Publications - AR 2010 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical DGGS AR 2010 Publication Details Title: Alaska Division of Geological & Geophysical Surveys Annual Report Authors: DGGS Staff Publication Date: Jan 2011 Publisher: Alaska Division of Geological &

  5. Atmospheric and Geophysical Sciences Division Program Report, 1988--1989

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1990-06-01

    In 1990, the Atmospheric and Geophysical Sciences Division begins its 17th year as a division. As the Division has grown over the years, its modeling capabilities have expanded to include a broad range of time and space scales ranging from hours to decades and from local to global. Our modeling is now reaching out from its atmospheric focus to treat linkages with the oceans and the land. In this report, we describe the Division's goal and organizational structure. We also provide tables and appendices describing the Division's budget, personnel, models, and publications. 2 figs., 1 tab.

  6. 25 CFR 227.19 - Division orders.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 25 Indians 1 2012-04-01 2011-04-01 true Division orders. 227.19 Section 227.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a...

  7. 25 CFR 227.19 - Division orders.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 25 Indians 1 2013-04-01 2013-04-01 false Division orders. 227.19 Section 227.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a...

  8. 25 CFR 227.19 - Division orders.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 25 Indians 1 2014-04-01 2014-04-01 false Division orders. 227.19 Section 227.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a...

  9. Criminal Division - Alaska Department of Law

    Science.gov Websites

    Criminal Division The Criminal Division works to assure safe and healthy communities by prosecuting and live in safe and healthy communities. The day-to-day prosecution services are carried out by the implicated in environmental crimes from further operations that damage the environment. The ECU is partially

  10. 25 CFR 227.19 - Division orders.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 25 Indians 1 2010-04-01 2010-04-01 false Division orders. 227.19 Section 227.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a...

  11. 25 CFR 227.19 - Division orders.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 25 Indians 1 2011-04-01 2011-04-01 false Division orders. 227.19 Section 227.19 Indians BUREAU OF INDIAN AFFAIRS, DEPARTMENT OF THE INTERIOR ENERGY AND MINERALS LEASING OF CERTAIN LANDS IN WIND RIVER INDIAN RESERVATION, WYOMING, FOR OIL AND GAS MINING Rents and Royalties § 227.19 Division orders. (a...

  12. Investigation of chemically-reacting supersonic internal flows

    NASA Technical Reports Server (NTRS)

    Chitsomboon, T.; Tiwari, S. N.

    1985-01-01

    This report covers work done on the research project Analysis and Computation of Internal Flow Field in a Scramjet Engine. The work is supported by the NASA Langley Research Center (Computational Methods Branch of the High-Speed Aerodynamics Division) through research grant NAG1-423. The governing equations of two-dimensional chemically-reacting flows are presented together with the global two-step chemistry model. The finite-difference algorithm used is illustrated and the method of circumventing the stiffness is discussed. The computer program developed is used to solve two model problems of a premixed chemically-reacting flow. The results obtained are physically reasonable.

  13. The stem cell division theory of cancer.

    PubMed

    López-Lázaro, Miguel

    2018-03-01

    All cancer registries constantly show striking differences in cancer incidence by age and among tissues. For example, lung cancer is diagnosed hundreds of times more often at age 70 than at age 20, and lung cancer in nonsmokers occurs thousands of times more frequently than heart cancer in smokers. An analysis of these differences using basic concepts in cell biology indicates that cancer is the end-result of the accumulation of cell divisions in stem cells. In other words, the main determinant of carcinogenesis is the number of cell divisions that the DNA of a stem cell has accumulated in any type of cell from the zygote. Cell division, process by which a cell copies and separates its cellular components to finally split into two cells, is necessary to produce the large number of cells required for living. However, cell division can lead to a variety of cancer-promoting errors, such as mutations and epigenetic mistakes occurring during DNA replication, chromosome aberrations arising during mitosis, errors in the distribution of cell-fate determinants between the daughter cells, and failures to restore physical interactions with other tissue components. Some of these errors are spontaneous, others are promoted by endogenous DNA damage occurring during quiescence, and others are influenced by pathological and environmental factors. The cell divisions required for carcinogenesis are primarily caused by multiple local and systemic physiological signals rather than by errors in the DNA of the cells. As carcinogenesis progresses, the accumulation of DNA errors promotes cell division and eventually triggers cell division under permissive extracellular environments. The accumulation of cell divisions in stem cells drives not only the accumulation of the DNA alterations required for carcinogenesis, but also the formation and growth of the abnormal cell populations that characterize the disease. This model of carcinogenesis provides a new framework for understanding the

  14. Couples' Attitudes, Childbirth, and the Division of Labor

    ERIC Educational Resources Information Center

    Jansen, Miranda; Liefbroer, Aart C.

    2006-01-01

    In this article, the authors examine effects of partners' attitudes on the timing of the birth of a first child, the division of domestic labor, the division of child care, and the division of paid labor of couples. They use data from the Panel Study of Social Integration in the Netherlands, which includes independent measures of both partners'…

  15. Physics division annual report 2000.

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Thayer, K., ed.

    2001-10-04

    This report summarizes the research performed in 2000 in the Physics Division of Argonne National Laboratory. The Division's programs include operation of ATLAS as a national user facility, nuclear structure and reaction research, nuclear theory and medium energy physics research, and accelerator research and development. As the Nuclear Science Advisory Committee and the nuclear science community create a new long range plan for the field in 2001, it is clear that the research of the Division is closely aligned with and continues to help define the national goals of our field. The NSAC 2001 Long Range Plan recommends as themore » highest priority for major new construction the Rare Isotope Accelerator (RIA), a bold step forward for nuclear structure and nuclear astrophysics. The accelerator R&D in the Physics Division has made major contributions to almost all aspects of the RIA design concept and the community was convinced that this project is ready to move forward. 2000 saw the end of the first Gammasphere epoch at ATLAS, One hundred Gammasphere experiments were completed between January 1998 and March 2000, 60% of which used the Fragment Mass Analyzer to provide mass identification in the reaction. The experimental program at ATLAS then shifted to other important research avenues including proton radioactivity, mass measurements with the Canadian Penning Trap and measurements of high energy gamma-rays in nuclear reactions with the MSU/ORNL/Texas A&M BaF{sub 2} array. ATLAS provided 5460 beam-research hours for user experiments and maintained an operational reliability of 95%. Radioactive beams accounted for 7% of the beam time. ATLAS also provided a crucial test of a key RIA concept, the ability to accelerate multiple charge states in a superconducting heavy-ion linac. This new capability was immediately used to increase the performance for a scheduled experiment. The medium energy program continued to make strides in examining how the quark-gluon structure

  16. Biology Division progress report, October 1, 1991--September 30, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Hartman, F.C.; Cook, J.S.

    This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1991, through September 30, 1993. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report.

  17. Division of Biological and Medical Research annual technical report, 1981

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenthal, M.W.

    1982-06-01

    This report summarizes research during 1981 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Low Level Radiation include comparison of lifetime effects in mice of low level neutron and gamma irradiation, delineation of the responses of dogs to continuous low level gamma irradiation, elucidation of mechanisms of radiation damage and repair in mammalian cells, and study of the genetic effects of high LET radiations. Carcinogenesis research addresses mechanisms of tumor initiation and promotion in rat liver, chemical carcinogenesis in cultured mammalian cells, and molecular and genetic mechanisms of chemical and ultraviolet mutagenesis in bacteria. Researchmore » in Toxicology uses a variety of cellular, whole animal, and chronobiological end points, chemical separations, and statistical models to evaluate the hazards and mechanisms of actions of metals, coal gasification by products, and other energy-related pollutants. Human Protein Index studies develop two-dimensional electrophoresis systems for diagnosis and detection of cancer and other disease. Biophysics research includes fundamental structural and biophysical investigations of immunoglobulins and key biological molecules using NMR, crystallographic, and x-ray and neutron small-angle scattering techniques. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.« less

  18. PREFACE: 14th General Conference of the Condensed Matter Division

    NASA Astrophysics Data System (ADS)

    de Segovia, José L.; Flores, F.; García-Moliner, F.

    1994-01-01

    This volume contains the proceedings of the 14th General Conference of the Condensed Matter Division, GCCMD-14, held on 28-31 March 1994, at the Faculty of Civil Engineering of the Polytechnical University of Madrid. The publication contains the Plenary and Invited Lectures of those authors who agreed to publish their presentations. The meeting was organized by the Spanish Vacuum Society, ASEVA, under the auspices of the Condensed Matter Division of the European Physical Society, CMD-EPS. The Conference was attended by 466 participants mostly from Europe. The emphasis of the Conference was mainly on: Semiconductors and Insulators Surfaces and Interfaces Liquids and Statistical Mechanics Magnetism and Metals Macromolecules and Chemical Physics The 554 contributions were presented as 6 plenary lectures, 67 invited lectures, 140 oral presentation and 341 poster presentation, in five parallel sessions. The guest Editors are grateful to those authors who sent their contribution for the publication, to the Organizing Committee, to the International Advisory and Programme Committee and to the Local Committee for their excellent work. We also wish to thank those colleagues who took on the hard task of helping in refereeing the papers. It is also a pleasure to thank the Physica Scripta Editor and Editorial Board of Physica Scripta.

  19. Parallel optoelectronic trinary signed-digit division

    NASA Astrophysics Data System (ADS)

    Alam, Mohammad S.

    1999-03-01

    The trinary signed-digit (TSD) number system has been found to be very useful for parallel addition and subtraction of any arbitrary length operands in constant time. Using the TSD addition and multiplication modules as the basic building blocks, we develop an efficient algorithm for performing parallel TSD division in constant time. The proposed division technique uses one TSD subtraction and two TSD multiplication steps. An optoelectronic correlator based architecture is suggested for implementation of the proposed TSD division algorithm, which fully exploits the parallelism and high processing speed of optics. An efficient spatial encoding scheme is used to ensure better utilization of space bandwidth product of the spatial light modulators used in the optoelectronic implementation.

  20. The representation of multiplication and division facts in memory.

    PubMed

    De Brauwer, Jolien; Fias, Wim

    2011-01-01

    Recently, using a training paradigm, Campbell and Agnew (2009) observed cross-operation response time savings with nonidentical elements (e.g., practice 3 + 2, test 5 - 2) for addition and subtraction, showing that a single memory representation underlies addition and subtraction performance. Evidence for cross-operation savings between multiplication and division have been described frequently (e.g., Campbell, Fuchs-Lacelle, & Phenix, 2006) but they have always been attributed to a mediation strategy (reformulating a division problem as a multiplication problem, e.g., Campbell et al., 2006). Campbell and Agnew (2009) therefore concluded that there exists a fundamental difference between addition and subtraction on the one hand and multiplication and division on the other hand. However, our results suggest that retrieval savings between inverse multiplication and division problems can be observed. Even for small problems (solved by direct retrieval) practicing a division problem facilitated the corresponding multiplication problem and vice versa. These findings indicate that shared memory representations underlie multiplication and division retrieval. Hence, memory and learning processes do not seem to differ fundamentally between addition-subtraction and multiplication-division.

  1. Chemical Expertise: Chemistry in the Royal Prussian Porcelain Manufactory.

    PubMed

    Klein, Ursula

    2014-01-01

    Eighteenth-century chemists defined chemistry as both a "science and an art." By "chemical art" they meant not merely experimentation but also parts of certain arts and crafts. This raises the question of how to identify the "chemical parts" of the arts and crafts in eighteenth-century Europe. In this essay I tackle this question with respect to porcelain manufacture. My essay begins with a brief discussion of historiographical problems related to this question. It then analyzes practices involved in porcelain manufacture that can be reasonably identified as chemical practices or a chemical art. My analysis yields evidence for the argument that chemical experts and expertise fulfilled distinct technical functions in porcelain manufacture and, by extension, in eighteenth-century "big industry," along with its system of division of labor.

  2. An Analysis of Vertebral Stress and BMD During +Gz Impact Accelerations

    DTIC Science & Technology

    2007-04-01

    Responses During Laboratory Frontal –Gx Axis Impact Tests. AFRL Technical Report AFRL-HE-WP-TR-2001-0022. 9) Buhrman, J.R., Plaga , J.A., Cheng, H...University of Munich. Naval Biodynamics Laboratory, New Orleans, LA. 4) Buhrman, J.R., Plaga , J.A., Cheng, H., Mosher, S.E. (2001) The AFRL Biodynamics

  3. Friday's Agenda | Division of Cancer Prevention

    Cancer.gov

    TimeAgenda8:00 am - 8:10 amWelcome and Opening RemarksLeslie Ford, MDAssociate Director for Clinical ResearchDivision of Cancer Prevention, NCIEva Szabo, MD Chief, Lung and Upper Aerodigestive Cancer Research GroupDivision of Cancer Prevention, NCI8:10 am - 8:40 amClinical Trials Statistical Concepts for Non-StatisticiansKevin Dodd, PhD |

  4. Animating the biodynamics of soil thickness using process vector analysis: A dynamic denudation approach to soil formation

    USGS Publications Warehouse

    Johnson, D.L.; Domier, J.E.J.; Johnson, D.N.

    2005-01-01

    This paper expands the dynamic denudation framework of landscape evolution by providing new process insights and details on how soil and its signature morphological feature, the biomantle, form and function in the environment. We examine soils and their biomantles from disparate parts of the world, from the tropics through midlatitudes and hyperarid through perhumid, a range that exhibits varying environments for, and of, life. We then explicate the process pathways that cause soils to thicken and thin, and to even disappear, then reform. We do this by examining thickness relationships, where soil thickness stand biomantle thickness bt are functions of upbuilding u and deepening d minus removal r processes, hence st/bt=f(u+d-r). Upbuilding has two subsets, u1, which includes all exogenous (allochthonous-outside) mineral and/or organic inputs to the soil system, and u2, which includes all endogenous (autochthonous-in situ) processes and productions, including weathering. Exogenous u1 inputs include eolian and slopewash inputs (sedimentations) of mineral and organic materials, mass wasting accumulations and the like. Endogenous u2 processes and productions include the sum of in situ bioturbations, biosynthetic productions, organic accumulations, biovoid productions, weathering and volume increases caused by their sum. Endogenous upbuildings, which dominantly occur in the biomantle, are basically biodynamic bd processes and productions, hence u2=bd. Therefore, if exogenous upbuildings u1 are minimal or zero, then biomantle thickness bt is expressed by bt=f(u2-r) or bt=f(bd-r). Drawing on these relationships, we employ a graphic-conceptual device called process vector analysis in a digital animation (see supplementary materials or cf. https://netfiles.uiuc.edu/jdomier/www/temp/ biomantle.html) that illustrates the main pathways that form both Earth's soil and its unique epidermis, the biomantle. We then discuss the main elements of the animation using still frames that

  5. Physics division. Progress report, January 1, 1995--December 31, 1996

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Stewart, M.; Bacon, D.S.; Aine, C.J.

    1997-10-01

    This issue of the Physics Division Progress Report describes progress and achievements in Physics Division research during the period January 1, 1995-December 31, 1996. The report covers the five main areas of experimental research and development in which Physics Division serves the needs of Los Alamos National Laboratory and the nation in applied and basic sciences: (1) biophysics, (2) hydrodynamic physics, (3) neutron science and technology, (4) plasma physics, and (5) subatomic physics. Included in this report are a message from the Division Director, the Physics Division mission statement, an organizational chart, descriptions of the research areas of the fivemore » groups in the Division, selected research highlights, project descriptions, the Division staffing and funding levels for FY95-FY97, and a list of publications and presentations.« less

  6. 2008 Joint Chemical Biological, Radiological and Nuclear (CBRN) Conference and Exhibition

    DTIC Science & Technology

    2008-06-26

    Untitled Document 2008cbrn.html[5/16/ 2016 10:15:46 AM] 2008 Joint Chemical Biological, Radiological and Nuclear (CBRN) Conference & Exhibition... 2016 10:15:46 AM] Mr. Fred Crowson, Chief, Physical Science and Technology Division, Joint Science & Technology Office for Chemical and Biological... analysis Detect and measure alpha, beta, gamma, neutron, and x-ray emissions Levels A, B, and C capable Level A Level B 2-Jul-08 10 Extract Capabilities

  7. Lead from the center. How to manage divisions dynamically.

    PubMed

    Raynor, M E; Bower, J L

    2001-05-01

    Conventional wisdom holds that a company's divisions should be given almost total autonomy--especially under conditions of uncertainty--because they are closer to emerging technologies, customers, and competitors than corporate headquarters could ever be. But research from Michael Raynor and Joseph Bower suggests that the corporate office should be more, not less, directive in turbulent markets. Rapid changes in an industry make it difficult to predict where and when synergies among divisions might emerge. With so many possibilities and such uncertainty, companies can't afford to sacrifice their ability to flexibly execute business strategy. Corporate headquarters must play an active role in defining the scope of division-level strategy, the authors say, so that divisions do not act in ways that undermine opportunities to collaborate in the future. But neither can companies afford to sacrifice the competitiveness of their divisions as stand-alone businesses. In creating corporate-level strategic flexibility, a corporate office must balance the need for divisional autonomy now with the potential need for cooperation in the future. Through an examination of four corporations--Sprint, WPP, Teradyne, and Viacom--the authors challenge traditional approaches to diversification in which a company's divisions are either related (they share resources and collaborate) or unrelated (they compete for resources and operate as stand-alone businesses). They argue that companies should adopt a dynamic approach to cooperation among divisions, enabling varying degrees of relatedness between divisions depending on strategic circumstances. The authors offer four tactics to help executives manage divisions dynamically.

  8. 24 CFR 4.36 - Action by the Ethics Law Division.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 24 Housing and Urban Development 1 2011-04-01 2011-04-01 false Action by the Ethics Law Division... the Ethics Law Division. (a) After review of the Inspector General's report, the Ethics Law Division... that a violation of Section 103 or this subpart B has occurred. (b) If the Ethics Law Division...

  9. 24 CFR 4.36 - Action by the Ethics Law Division.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 24 Housing and Urban Development 1 2010-04-01 2010-04-01 false Action by the Ethics Law Division... the Ethics Law Division. (a) After review of the Inspector General's report, the Ethics Law Division... that a violation of Section 103 or this subpart B has occurred. (b) If the Ethics Law Division...

  10. 24 CFR 4.36 - Action by the Ethics Law Division.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 24 Housing and Urban Development 1 2013-04-01 2013-04-01 false Action by the Ethics Law Division... the Ethics Law Division. (a) After review of the Inspector General's report, the Ethics Law Division... that a violation of Section 103 or this subpart B has occurred. (b) If the Ethics Law Division...

  11. 24 CFR 4.36 - Action by the Ethics Law Division.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 24 Housing and Urban Development 1 2014-04-01 2014-04-01 false Action by the Ethics Law Division... the Ethics Law Division. (a) After review of the Inspector General's report, the Ethics Law Division... that a violation of Section 103 or this subpart B has occurred. (b) If the Ethics Law Division...

  12. 24 CFR 4.36 - Action by the Ethics Law Division.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 24 Housing and Urban Development 1 2012-04-01 2012-04-01 false Action by the Ethics Law Division... the Ethics Law Division. (a) After review of the Inspector General's report, the Ethics Law Division... that a violation of Section 103 or this subpart B has occurred. (b) If the Ethics Law Division...

  13. Cell division is dispensable but not irrelevant in Streptomyces.

    PubMed

    McCormick, Joseph R

    2009-12-01

    In part, members of the genus Streptomyces have been studied because they produce many important secondary metabolites with antibiotic activity and for the interest in their relatively elaborate life cycle. These sporulating filamentous bacteria are remarkably synchronous for division and genome segregation in specialized aerial hyphae. Streptomycetes share some, but not all, of the division genes identified in the historic model rod-shaped organisms. Curiously, normally essential cell division genes are dispensable for growth and viability of Streptomyces coelicolor. Mainly, cell division plays a more important role in the developmental phase of life than during vegetative growth. Dispensability provides an advantageous genetic system to probe the mechanisms of division proteins, especially those with functions that are poorly understood.

  14. 28 CFR 3.2 - Assistant Attorney General, Criminal Division.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 28 Judicial Administration 1 2011-07-01 2011-07-01 false Assistant Attorney General, Criminal Division. 3.2 Section 3.2 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.2 Assistant Attorney General, Criminal Division. The Assistant Attorney General, Criminal Division, is authorized to...

  15. 28 CFR 3.2 - Assistant Attorney General, Criminal Division.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 28 Judicial Administration 1 2012-07-01 2012-07-01 false Assistant Attorney General, Criminal Division. 3.2 Section 3.2 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.2 Assistant Attorney General, Criminal Division. The Assistant Attorney General, Criminal Division, is authorized to...

  16. 28 CFR 3.2 - Assistant Attorney General, Criminal Division.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 28 Judicial Administration 1 2013-07-01 2013-07-01 false Assistant Attorney General, Criminal Division. 3.2 Section 3.2 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.2 Assistant Attorney General, Criminal Division. The Assistant Attorney General, Criminal Division, is authorized to...

  17. 28 CFR 3.2 - Assistant Attorney General, Criminal Division.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 28 Judicial Administration 1 2014-07-01 2014-07-01 false Assistant Attorney General, Criminal Division. 3.2 Section 3.2 Judicial Administration DEPARTMENT OF JUSTICE GAMBLING DEVICES § 3.2 Assistant Attorney General, Criminal Division. The Assistant Attorney General, Criminal Division, is authorized to...

  18. Bibliography of Research Reports and Publications Issued by the Biodynamics and Bioengineering Division, 1944-1984.

    DTIC Science & Technology

    1985-04-01

    Ratino, R.K.H. Geber , A.A. Karl, D.R. Nelson, "OPTO Electronic Methodology Suitable for Electroretinographic Investigations During Environmental Stess...R.K.H. Geber , A.A. Karl, D.R. Nelson, "OPTO Electronic Methodology Suitable for Electroretinographic Investigations During Environmental Stess...6 Section M -Page 167 Author Index Gaudio, R. L-62, 67 Gawain,G.C.V. A-12 Geber ,R.K.H. G-42,H-22 Geer,R.L. F-92 Gehrich,J.L. A-273 Gell,C.F. D-33,F-97

  19. Division of labour in the yeast: Saccharomyces cerevisiae.

    PubMed

    Wloch-Salamon, Dominika M; Fisher, Roberta M; Regenberg, Birgitte

    2017-10-01

    Division of labour between different specialized cell types is a central part of how we describe complexity in multicellular organisms. However, it is increasingly being recognized that division of labour also plays an important role in the lives of predominantly unicellular organisms. Saccharomyces cerevisiae displays several phenotypes that could be considered a division of labour, including quiescence, apoptosis and biofilm formation, but they have not been explicitly treated as such. We discuss each of these examples, using a definition of division of labour that involves phenotypic variation between cells within a population, cooperation between cells performing different tasks and maximization of the inclusive fitness of all cells involved. We then propose future research directions and possible experimental tests using S. cerevisiae as a model organism for understanding the genetic mechanisms and selective pressures that can lead to the evolution of the very first stages of a division of labour. Copyright © 2017 John Wiley & Sons, Ltd. Copyright © 2017 John Wiley & Sons, Ltd.

  20. The distinctive cell division interactome of Neisseria gonorrhoeae.

    PubMed

    Zou, Yinan; Li, Yan; Dillon, Jo-Anne R

    2017-12-12

    Bacterial cell division is an essential process driven by the formation of a Z-ring structure, as a cytoskeletal scaffold at the mid-cell, followed by the recruitment of various proteins which form the divisome. The cell division interactome reflects the complement of different interactions between all divisome proteins. To date, only two cell division interactomes have been characterized, in Escherichia coli and in Streptococcus pneumoniae. The cell divison proteins encoded by Neisseria gonorrhoeae include FtsZ, FtsA, ZipA, FtsK, FtsQ, FtsI, FtsW, and FtsN. The purpose of the present study was to characterize the cell division interactome of N. gonorrhoeae using several different methods to identify protein-protein interactions. We also characterized the specific subdomains of FtsA implicated in interactions with FtsZ, FtsQ, FtsN and FtsW. Using a combination of bacterial two-hybrid (B2H), glutathione S-transferase (GST) pull-down assays, and surface plasmon resonance (SPR), nine interactions were observed among the eight gonococcal cell division proteins tested. ZipA did not interact with any other cell division proteins. Comparisons of the N. gonorrhoeae cell division interactome with the published interactomes from E. coli and S. pneumoniae indicated that FtsA-FtsZ and FtsZ-FtsK interactions were common to all three species. FtsA-FtsW and FtsK-FtsN interactions were only present in N. gonorrhoeae. The 2A and 2B subdomains of FtsA Ng were involved in interactions with FtsQ, FtsZ, and FtsN, and the 2A subdomain was involved in interaction with FtsW. Results from this research indicate that N. gonorrhoeae has a distinctive cell division interactome as compared with other microorganisms.

  1. Estimating division and death rates from CFSE data

    NASA Astrophysics Data System (ADS)

    de Boer, Rob J.; Perelson, Alan S.

    2005-12-01

    The division tracking dye, carboxyfluorescin diacetate succinimidyl ester (CFSE) is currently the most informative labeling technique for characterizing the division history of cells in the immune system. Gett and Hodgkin (Nat. Immunol. 1 (2000) 239-244) have proposed to normalize CFSE data by the 2-fold expansion that is associated with each division, and have argued that the mean of the normalized data increases linearly with time, t, with a slope reflecting the division rate p. We develop a number of mathematical models for the clonal expansion of quiescent cells after stimulation and show, within the context of these models, under which conditions this approach is valid. We compare three means of the distribution of cells over the CFSE profile at time t: the mean, [mu](t), the mean of the normalized distribution, [mu]2(t), and the mean of the normalized distribution excluding nondivided cells, .In the simplest models, which deal with homogeneous populations of cells with constant division and death rates, the normalized frequency distribution of the cells over the respective division numbers is a Poisson distribution with mean [mu]2(t)=pt, where p is the division rate. The fact that in the data these distributions seem Gaussian is therefore insufficient to establish that the times at which cells are recruited into the first division have a Gaussian variation because the Poisson distribution approaches the Gaussian distribution for large pt. Excluding nondivided cells complicates the data analysis because , and only approaches a slope p after an initial transient.In models where the first division of the quiescent cells takes longer than later divisions, all three means have an initial transient before they approach an asymptotic regime, which is the expected [mu](t)=2pt and . Such a transient markedly complicates the data analysis. After the same initial transients, the normalized cell numbers tend to decrease at a rate e-dt, where d is the death rate

  2. Quantitative regulation of B cell division destiny by signal strength.

    PubMed

    Turner, Marian L; Hawkins, Edwin D; Hodgkin, Philip D

    2008-07-01

    Differentiation to Ab secreting and isotype-switched effector cells is tightly linked to cell division and therefore the degree of proliferation strongly influences the nature of the immune response. The maximum number of divisions reached, termed the population division destiny, is stochastically distributed in the population and is an important parameter in the quantitative outcome of lymphocyte responses. In this study, we further assessed the variables that regulate B cell division destiny in vitro in response to T cell- and TLR-dependent stimuli. Both the concentration and duration of stimulation were able to regulate the average maximum number of divisions undergone for each stimulus. Notably, a maximum division destiny was reached during provision of repeated saturating stimulation, revealing that an intrinsic limit to proliferation exists even under these conditions. This limit was linked directly to division number rather than time of exposure to stimulation and operated independently of the survival regulation of the cells. These results demonstrate that a B cell population's division destiny is regulable by the stimulatory conditions up to an inherent maximum value. Division destiny is a crucial parameter in regulating the extent of B cell responses and thereby also the nature of the immune response mounted.

  3. Structures Division

    NASA Technical Reports Server (NTRS)

    1997-01-01

    The NASA Lewis Research Center Structures Division is an international leader and pioneer in developing new structural analysis, life prediction, and failure analysis related to rotating machinery and more specifically to hot section components in air-breathing aircraft engines and spacecraft propulsion systems. The research consists of both deterministic and probabilistic methodology. Studies include, but are not limited to, high-cycle and low-cycle fatigue as well as material creep. Studies of structural failure are at both the micro- and macrolevels. Nondestructive evaluation methods related to structural reliability are developed, applied, and evaluated. Materials from which structural components are made, studied, and tested are monolithics and metal-matrix, polymer-matrix, and ceramic-matrix composites. Aeroelastic models are developed and used to determine the cyclic loading and life of fan and turbine blades. Life models are developed and tested for bearings, seals, and other mechanical components, such as magnetic suspensions. Results of these studies are published in NASA technical papers and reference publication as well as in technical society journal articles. The results of the work of the Structures Division and the bibliography of its publications for calendar year 1995 are presented.

  4. Biology Division progress report, October 1, 1993--September 30, 1995

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1995-10-01

    This Progress Report summarizes the research endeavors of the Biology Division of the Oak Ridge National Laboratory during the period October 1, 1993, through September 30, 1995. The report is structured to provide descriptions of current activities and accomplishments in each of the Division`s major organizational units. Lists of information to convey the entire scope of the Division`s activities are compiled at the end of the report. Attention is focused on the following research activities: molecular, cellular, and cancer biology; mammalian genetics and development; genome mapping program; and educational activities.

  5. Parkin suppresses Drp1-independent mitochondrial division.

    PubMed

    Roy, Madhuparna; Itoh, Kie; Iijima, Miho; Sesaki, Hiromi

    2016-07-01

    The cycle of mitochondrial division and fusion disconnect and reconnect individual mitochondria in cells to remodel this energy-producing organelle. Although dynamin-related protein 1 (Drp1) plays a major role in mitochondrial division in cells, a reduced level of mitochondrial division still persists even in the absence of Drp1. It is unknown how much Drp1-mediated mitochondrial division accounts for the connectivity of mitochondria. The role of a Parkinson's disease-associated protein-parkin, which biochemically and genetically interacts with Drp1-in mitochondrial connectivity also remains poorly understood. Here, we quantified the number and connectivity of mitochondria using mitochondria-targeted photoactivatable GFP in cells. We show that the loss of Drp1 increases the connectivity of mitochondria by 15-fold in mouse embryonic fibroblasts (MEFs). While a single loss of parkin does not affect the connectivity of mitochondria, the connectivity of mitochondria significantly decreased compared with a single loss of Drp1 when parkin was lost in the absence of Drp1. Furthermore, the loss of parkin decreased the frequency of depolarization of the mitochondrial inner membrane that is caused by increased mitochondrial connectivity in Drp1-knockout MEFs. Therefore, our data suggest that parkin negatively regulates Drp1-indendent mitochondrial division. Copyright © 2016 Elsevier Inc. All rights reserved.

  6. Division V: Commission 42: Close Binaries

    NASA Astrophysics Data System (ADS)

    Ribas, Ignasi; Richards, Mercedes T.; Rucinski, Slavek; Bradstreet, David H.; Harmanec, Petr; Kaluzny, Janusz; Mikolajewska, Joanna; Munari, Ulisse; Niarchos, Panagiotis; Olah, Katalin; Pribulla, Theodor; Scarfe, Colin D.; Torres, Guillermo

    2015-08-01

    Commission 42 (C42) co-organized, together with Commission 27 (C27) and Division V (Div V) as a whole, a full day of science and business sessions that were held on 24 August 2012. The program included time slots for discussion of business matters related to Div V, C27 and C42, and two sessions of 2 hours each devoted to science talks of interest to both C42 and C27. In addition, we had a joint session between Div IV and Div V motivated by the proposal to reformulate the division structure of the IAU and the possible merger of the two divisions into a new Div G. The current report gives an account of the matters discussed during the business session of C42.

  7. Exploratory Research and Development Fund, FY 1990. Report on Lawrence Berkeley Laboratory

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R&D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R&D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicine and radiationmore » biophysics.« less

  8. Exploratory Research and Development Fund, FY 1990

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-05-01

    The Lawrence Berkeley Laboratory Exploratory R D Fund FY 1990 report is compiled from annual reports submitted by principal investigators following the close of the fiscal year. This report describes the projects supported and summarizes their accomplishments. It constitutes a part of an Exploratory R D Fund (ERF) planning and documentation process that includes an annual planning cycle, projection selection, implementation, and review. The research areas covered in this report are: Accelerator and fusion research; applied science; cell and molecular biology; chemical biodynamics; chemical sciences; earth sciences; engineering; information and computing sciences; materials sciences; nuclear science; physics and research medicinemore » and radiation biophysics.« less

  9. Cognitive and Neural Sciences Division, 1991 Programs.

    ERIC Educational Resources Information Center

    Vaughan, Willard S., Ed.

    This report documents research and development performed under the sponsorship of the Cognitive and Neural Sciences Division of the Office of Naval Research in fiscal year 1991. It provides abstracts (title, principal investigator, project code, objective, approach, progress, and related reports) of projects of three program divisions (cognitive…

  10. Imaging mycobacterial growth and division with a fluorogenic probe.

    PubMed

    Hodges, Heather L; Brown, Robert A; Crooks, John A; Weibel, Douglas B; Kiessling, Laura L

    2018-05-15

    Control and manipulation of bacterial populations requires an understanding of the factors that govern growth, division, and antibiotic action. Fluorescent and chemically reactive small molecule probes of cell envelope components can visualize these processes and advance our knowledge of cell envelope biosynthesis (e.g., peptidoglycan production). Still, fundamental gaps remain in our understanding of the spatial and temporal dynamics of cell envelope assembly. Previously described reporters require steps that limit their use to static imaging. Probes that can be used for real-time imaging would advance our understanding of cell envelope construction. To this end, we synthesized a fluorogenic probe that enables continuous live cell imaging in mycobacteria and related genera. This probe reports on the mycolyltransferases that assemble the mycolic acid membrane. This peptidoglycan-anchored bilayer-like assembly functions to protect these cells from antibiotics and host defenses. Our probe, quencher-trehalose-fluorophore (QTF), is an analog of the natural mycolyltransferase substrate. Mycolyltransferases process QTF by diverting their normal transesterification activity to hydrolysis, a process that unleashes fluorescence. QTF enables high contrast continuous imaging and the visualization of mycolyltransferase activity in cells. QTF revealed that mycolyltransferase activity is augmented before cell division and localized to the septa and cell poles, especially at the old pole. This observed localization suggests that mycolyltransferases are components of extracellular cell envelope assemblies, in analogy to the intracellular divisomes and polar elongation complexes. We anticipate QTF can be exploited to detect and monitor mycobacteria in physiologically relevant environments.

  11. Space Science Division cumulative bibliography: 1989-1994

    NASA Technical Reports Server (NTRS)

    Morrison, D.

    1995-01-01

    The Space Science Division at NASA's Ames Research Center is dedicated to research in astrophysics, exobiology, and planetary science. These research programs are structured around the study of origins and evolution of stars, planets, planetary atmospheres, and life, and address some of the most fundamental questions pursued by science; questions that examine the origin of life and of our place in the universe. This bibliography is the accumulation of peer-reviewed publications authored by Division scientists for the years 1989 through 1994. The list includes 777 papers published in over 5 dozen scientific journals representing the high productivity and interdisciplinary nature of the Space Science Division.

  12. Division Planes Alternate in Spherical Cells of Escherichia coli

    PubMed Central

    Begg, K. J.; Donachie, W. D.

    1998-01-01

    In the spherical cells of Escherichia coli rodA mutants, division is initiated at a single point, from which a furrow extends progressively around the cell. Using “giant” rodA ftsA cells, we confirmed that each new division furrow is initiated at the midpoint of the previous division plane and runs perpendicular to it. PMID:9573213

  13. Research Networks Map | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States. Seven Major Programs' sites are shown on this map. | The Division of Cancer Prevention supports major scientific collaborations and research networks at more than 100 sites across the United States.

  14. Cognitive and Neural Sciences Division 1990 Programs.

    ERIC Educational Resources Information Center

    Vaughan, Willard S., Jr., Ed.

    Research and development efforts carried out under sponsorship of the Cognitive and Neural Sciences Division of the Office of Naval Research during fiscal year 1990 are described in this compilation of project description summaries. The Division's research is organized in three types of programs: (1) Cognitive Science (the human learner--cognitive…

  15. The Changing Nature of Division III Athletics

    ERIC Educational Resources Information Center

    Beaver, William

    2014-01-01

    Non-selective Division III institutions often face challenges in meeting their enrollment goals. To ensure their continued viability, these schools recruit large numbers of student athletes. As a result, when compared to FBS (Football Bowl Division) institutions these schools have a much higher percentage of student athletes on campus and a…

  16. Understanding Division of Fractions: An Alternative View

    ERIC Educational Resources Information Center

    Fredua-Kwarteng, E.; Ahia, Francis

    2006-01-01

    The purpose of this paper is to offer three alternatives to patterns or visualization used to justify division of fraction "algorithm" invert and multiply". The three main approaches are historical, similar denominators and algebraic, that teachers could use to justify the standard algorithm of division of fraction. The historical approach uses…

  17. 3. Oblique view of 215 Division Street, looking southeast, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Oblique view of 215 Division Street, looking southeast, showing rear (west) facade and north side, Fairbanks Company appears at left and 215 Division Street is visible at right - 215 Division Street (House), Rome, Floyd County, GA

  18. 2. Oblique view of 215 Division Street, looking northeast, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    2. Oblique view of 215 Division Street, looking northeast, showing rear (west) facade and south side, 217 Division Street is visible at left and Fairbanks Company appears at right - 215 Division Street (House), Rome, Floyd County, GA

  19. 3. Oblique view of 213 Division Street, looking northeast, showing ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Oblique view of 213 Division Street, looking northeast, showing rear (west) facade and south side, 215 Division Street is visible at left and Fairbanks Company appears at right - 213 Division Street (House), Rome, Floyd County, GA

  20. The Impact of Reclassification from Division II to DI-AA and from Division I-AA to I-A on NCAA Member Institutions from 1993 to 2003

    ERIC Educational Resources Information Center

    Frieder, Laura L., Comp.; Fulks, Daniel L., Comp.

    2007-01-01

    Recent years have seen a number of National Collegiate Athletic Association (NCAA) Division II institutions seeking reclassification to Division I-AA and Division I-AA institutions moving to Division I-A. Yet, other schools that seem like natural candidates to reclassify have resisted. The purpose of this study is to investigate the impact of the…

  1. Division of Agriculture

    Science.gov Websites

    Department of Natural Resources logo, color scheme Department of Natural Resources Division of Agriculture Search Search DNR's site DNR State of Alaska Toggle main menu visibility Agriculture Home Programs Asset Disposals Alaska Caps Progam Board of Agriculture & Conservation Farm To School Program Grants

  2. 6. Contextual view of Fairbanks Company, looking south along Division ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    6. Contextual view of Fairbanks Company, looking south along Division Street, showing relationship of factory to surrounding area, 213, 215, & 217 Division Street appear on right side of street - Fairbanks Company, 202 Division Street, Rome, Floyd County, GA

  3. Publications - GMC 244 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Ridge Unit #1 well Authors: DGSI, Inc. Publication Date: 1995 Publisher: Alaska Division of Geological Union Oil Company of California Trail Ridge Unit #1 well: Alaska Division of Geological &

  4. JTF CapMed Warrior Transition Division

    DTIC Science & Technology

    2011-01-25

    The Quadruple Aim: Working Together, Achieving Success 2011 Military Health System Conference JTF CapMed Warrior Transition Division 25 January 2011...Colonel Julia Adams 1 Military Health System Conference Joint Task Force National Capital Region Medical (JTF CapMed ) Report Documentation Page Form...DATES COVERED 00-00-2011 to 00-00-2011 4. TITLE AND SUBTITLE JTF CapMed Warrior Transition Division 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c

  5. Publications - STATEMAP Project | Alaska Division of Geological &

    Science.gov Websites

    ., 2008, Surficial-geologic map of the Salcha River-Pogo area, Big Delta Quadrangle, Alaska: Alaska , Engineering - geologic map, Alaska Highway corridor, Delta Junction to Dot Lake, Alaska: Alaska Division of geologic map of the Salcha River-Pogo area, Big Delta Quadrangle, Alaska: Alaska Division of Geological

  6. Using Texas Instruments Emulators as Teaching Tools in Quantitative Chemical Analysis

    ERIC Educational Resources Information Center

    Young, Vaneica Y.

    2011-01-01

    This technology report alerts upper-division undergraduate chemistry faculty and lecturers to the use of Texas Instruments emulators as virtual graphing calculators. These may be used in multimedia lectures to instruct students on the use of their graphing calculators to obtain solutions to complex chemical problems. (Contains 1 figure.)

  7. Predicting Chemical Toxicity from Proteomics and Computational Chemistry

    DTIC Science & Technology

    2008-07-30

    similarity spaces, BD Gute and SC Basak, SAR QSAR Environ. Res., 17, 37-51 (2006). Predicting pharmacological and toxicological activity of heterocyclic...affinity of dibenzofurans: a hierarchical QSAR approach, authored jointly by Basak and Mills; Division of Chemical Toxicology iii. Prediction of blood...biodescriptors vis-ä-vis chemodescriptors in predictive toxicology e) Development of integrated QSTR models using the combined set of chemodescriptors and

  8. History of Division 29, 1993-2013: another 20 years of psychotherapy.

    PubMed

    Williams, Elizabeth Nutt; Barnett, Jeffrey E; Canter, Mathilda B

    2013-03-01

    The history of Division 29 (Psychotherapy) of the American Psychological Association (APA) from 1993 to 2013 is reviewed. The 20 years of history can be traced via the Division's primary publications (the journal Psychotherapy and its newsletter Psychotherapy Bulletin) as well as the history of those who have served leadership roles in the Division and have won Divisional awards. Several recurring themes emerge related to the Division's articulations of its own identity, the Division's advocacy efforts vis-à-vis the profession and the APA, and the work of the Division on behalf of major social issues (such as disaster relief and the nation's health care).

  9. PHOTOCOPY OF DRAWING NO. F860, DIVISION AVENUE STATION, EAST ELEVATION ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    PHOTOCOPY OF DRAWING NO. F-860, DIVISION AVENUE STATION, EAST ELEVATION AND DETAILS, DRAWN BY W.H.C., MAR. 22, 1915. COURTESY OF THE DEPARTMENT OF PUBLIC UTILITIES, DIVISION OF WATER, CITY OF CLEVELAND. - Division Avenue Pumping Station & Filtration Plant, West 45th Street and Division Avenue, Cleveland, Cuyahoga County, OH

  10. Division of Forestry

    Science.gov Websites

    . In 2011, the Alaska State Legislature added 23,181 acres of commercial forest lands to the existing Southeast State Forest. The Division conducts personal use, commercial timber, and fuel-wood sales. It Commercial Timber Sales General Firewood Permit Firewood Information Forestry GIS Website Reforestation

  11. ADP Analysis project for the Human Resources Management Division

    NASA Technical Reports Server (NTRS)

    Tureman, Robert L., Jr.

    1993-01-01

    The ADP (Automated Data Processing) Analysis Project was conducted for the Human Resources Management Division (HRMD) of NASA's Langley Research Center. The three major areas of work in the project were computer support, automated inventory analysis, and an ADP study for the Division. The goal of the computer support work was to determine automation needs of Division personnel and help them solve computing problems. The goal of automated inventory analysis was to find a way to analyze installed software and usage on a Macintosh. Finally, the ADP functional systems study for the Division was designed to assess future HRMD needs concerning ADP organization and activities.

  12. Engineering Research Division publication report, calendar year 1980

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Miller, E.K.; Livingston, P.L.; Rae, D.C.

    Each year the Engineering Research Division of the Electronics Engineering Department at Lawrence Livermore Laboratory has issued an internal report listing all formal publications produced by the Division during the calendar year. Abstracts of 1980 reports are presented.

  13. Publications - GMC 138 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    . OCS Y-0211-1 (Yakutat #1) well Authors: Unknown Publication Date: 1989 Publisher: Alaska Division of of cuttings from the Arco Alaska Inc. OCS Y-0211-1 (Yakutat #1) well: Alaska Division of Geological

  14. Cell-Division Behavior in a Heterogeneous Swarm Environment.

    PubMed

    Erskine, Adam; Herrmann, J Michael

    2015-01-01

    We present a system of virtual particles that interact using simple kinetic rules. It is known that heterogeneous mixtures of particles can produce particularly interesting behaviors. Here we present a two-species three-dimensional swarm in which a behavior emerges that resembles cell division. We show that the dividing behavior exists across a narrow but finite band of parameters and for a wide range of population sizes. When executed in a two-dimensional environment the swarm's characteristics and dynamism manifest differently. In further experiments we show that repeated divisions can occur if the system is extended by a biased equilibrium process to control the split of populations. We propose that this repeated division behavior provides a simple model for cell-division mechanisms and is of interest for the formation of morphological structure and to swarm robotics.

  15. Universal rule for the symmetric division of plant cells

    PubMed Central

    Besson, Sébastien; Dumais, Jacques

    2011-01-01

    The division of eukaryotic cells involves the assembly of complex cytoskeletal structures to exert the forces required for chromosome segregation and cytokinesis. In plants, empirical evidence suggests that tensional forces within the cytoskeleton cause cells to divide along the plane that minimizes the surface area of the cell plate (Errera’s rule) while creating daughter cells of equal size. However, exceptions to Errera’s rule cast doubt on whether a broadly applicable rule can be formulated for plant cell division. Here, we show that the selection of the plane of division involves a competition between alternative configurations whose geometries represent local area minima. We find that the probability of observing a particular division configuration increases inversely with its relative area according to an exponential probability distribution known as the Gibbs measure. Moreover, a comparison across land plants and their most recent algal ancestors confirms that the probability distribution is widely conserved and independent of cell shape and size. Using a maximum entropy formulation, we show that this empirical division rule is predicted by the dynamics of the tense cytoskeletal elements that lead to the positioning of the preprophase band. Based on the fact that the division plane is selected from the sole interaction of the cytoskeleton with cell shape, we posit that the new rule represents the default mechanism for plant cell division when internal or external cues are absent. PMID:21383128

  16. Towers of generalized divisible quantum codes

    NASA Astrophysics Data System (ADS)

    Haah, Jeongwan

    2018-04-01

    A divisible binary classical code is one in which every code word has weight divisible by a fixed integer. If the divisor is 2ν for a positive integer ν , then one can construct a Calderbank-Shor-Steane (CSS) code, where X -stabilizer space is the divisible classical code, that admits a transversal gate in the ν th level of Clifford hierarchy. We consider a generalization of the divisibility by allowing a coefficient vector of odd integers with which every code word has zero dot product modulo the divisor. In this generalized sense, we construct a CSS code with divisor 2ν +1 and code distance d from any CSS code of code distance d and divisor 2ν where the transversal X is a nontrivial logical operator. The encoding rate of the new code is approximately d times smaller than that of the old code. In particular, for large d and ν ≥2 , our construction yields a CSS code of parameters [[O (dν -1) ,Ω (d ) ,d ] ] admitting a transversal gate at the ν th level of Clifford hierarchy. For our construction we introduce a conversion from magic state distillation protocols based on Clifford measurements to those based on codes with transversal T gates. Our tower contains, as a subclass, generalized triply even CSS codes that have appeared in so-called gauge fixing or code switching methods.

  17. Peptidoglycan architecture can specify division planes in Staphylococcus aureus.

    PubMed

    Turner, Robert D; Ratcliffe, Emma C; Wheeler, Richard; Golestanian, Ramin; Hobbs, Jamie K; Foster, Simon J

    2010-06-15

    Division in Staphylococci occurs equatorially and on specific sequentially orthogonal planes in three dimensions, resulting, after incomplete cell separation, in the 'bunch of grapes' cluster organization that defines the genus. The shape of Staphylococci is principally maintained by peptidoglycan. In this study, we use Atomic Force Microscopy (AFM) and fluorescence microscopy with vancomycin labelling to examine purified peptidoglycan architecture and its dynamics in Staphylococcus aureus and correlate these with the cell cycle. At the presumptive septum, cells were found to form a large belt of peptidoglycan in the division plane before the centripetal formation of the septal disc; this often had a 'piecrust' texture. After division, the structures remain as orthogonal ribs, encoding the location of past division planes in the cell wall. We propose that this epigenetic information is used to enable S. aureus to divide in sequentially orthogonal planes, explaining how a spherical organism can maintain division plane localization with fidelity over many generations.

  18. CELL DIVISION IN A SPECIES OF ERWINIA. III. REVERSAL OF INHIBITION OF CELL DIVISION CAUSED BY D-AMINO ACIDS, PENICILLIN, AND ULTRA-VIOLET LIGHT

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Grula, E.A.; Grula, M.M.

    Inhibition of cell division in an Erwinia sp. occurs in the presence of any of six D-amino acids, penicillin, or ultraviolet light. Cell-division inhibition caused by D-amino acids is pH-dependent; however, elongation caused by penicillin occurs over a wide range of pH. Bulging and spheroplast formation in the presence of penicillin occurs only at pH values below 7.6; however, division continues to be inhibited at higher pH levels. Reversal of cell-division inhibition caused by two D-amino acids (phenylalanine and histidine) can be partially overcome by their respective L-isomers. Divalent cations (Zn, Ca, Mn) cause varying amounts of reversal of divisionmore » inhibition in all systems studied; each system appears to have an individual requirement. All induced division inhibitions, including that caused by penicillin, can be reversed by pantoyl lactone or omega methylpantoyl lactone. Evidence is presented and discussed concerning the possible importance of pantoyl lactone and divalent cations in terminal steps of the cell-division process in this organism. (auth)« less

  19. FMC: Expanding its chemical universe

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wood, A.

    1992-12-23

    With a portfolio ranging from defense systems to gold to food machinery - the source of its name - FMC Corp. (Chicago) ranks as a diversified conglomerate. The company's industrial chemicals operation consists of alkali chemicals, chiefly soda ash and derivatives: peroxygen chemicals, made up of hydrogen peroxide and other peroxygens; and phosphorus chemicals. FMC has about a 30% market share in each of these three. It also includes the Foret (Barcelona) division, part of FMC Europe. Moving lithium into FMC's specialties group reflects the R D-intensive nature of many lithium compounds, explains F. Wyman Morgan, director/group technology for themore » chemical product and specialty chemicals groups. FMC is also involved in collaborative research programs to develop lithium-based batteries and fuel cells. We have a decentralized business-oriented R D focus, Morgan says. The main thrusts in lithium are in developing organolithiums for drug synthesis. FMC also has a major industrial lithium business; it recently added a new butyl lithium unit in Texas and is looking to expand production through the development of lithium deposits in Latin America. But lithium is growing fastest in the downstream areas, says W. Reginald Hall, v.p. and group manager/specialty chemicals group. It has an unbelievable range of uses, he says, including catalytic applications in the pharmaceuticals industry. We are working on lithium compounds that allow you to drop a functional organic group into a molecule in a reliable way.« less

  20. A case study in pollution prevention at the Northrop Grumman B-2 division

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Haltmeyer, T.

    1995-12-31

    In 1990, Northrop Grumman Corporation outlined a pollution prevention program to be jointly chartered by all operating elements. This concept was expanded by the B-2 Division, to become a comprehensive industrial multimedia program known as Zero 2000. The Zero 2000 program mandates the elimination of releases of hazardous materials to air, land and water by 2000. Northrop Grumman B-2 Division has effectively identified and defined environmental needs associated with the operations and is meeting or exceeding pollution prevention goals to affect measurable improvements to the quality of air, land and water. Through the Zero 2000 program, they have achieved amore » reduction of over 85% in hazardous waste generated and a reduction of ozone-depleting chemical emissions by 90%. In addition, they have reduced mobile air pollution by approximately 280 tons per year; reduced water usage by an average of 34%; and, have reduced solid waste disposal by 55%. Their environmental needs were defined through a grass roots assessment by environmental staff members and other professionals. This evaluation emerged from a basic Northrop Grumman philosophy to find innovative solutions to technological problems.« less

  1. 49 CFR 176.605 - Care following leakage or sifting of Division 2.3 (poisonous gas) and Division 6.1 (poisonous...

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 49 Transportation 2 2010-10-01 2010-10-01 false Care following leakage or sifting of Division 2.3... Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF... (Poisonous Gas) and Division 6.1 (Poisonous) Materials § 176.605 Care following leakage or sifting of...

  2. 49 CFR 176.605 - Care following leakage or sifting of Division 2.3 (poisonous gas) and Division 6.1 (poisonous...

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 49 Transportation 2 2011-10-01 2011-10-01 false Care following leakage or sifting of Division 2.3... Regulations Relating to Transportation PIPELINE AND HAZARDOUS MATERIALS SAFETY ADMINISTRATION, DEPARTMENT OF... (Poisonous Gas) and Division 6.1 (Poisonous) Materials § 176.605 Care following leakage or sifting of...

  3. Oriented cell division: new roles in guiding skin wound repair and regeneration

    PubMed Central

    Yang, Shaowei; Ma, Kui; Geng, Zhijun; Sun, Xiaoyan; Fu, Xiaobing

    2015-01-01

    Tissue morphogenesis depends on precise regulation and timely co-ordination of cell division and also on the control of the direction of cell division. Establishment of polarity division axis, correct alignment of the mitotic spindle, segregation of fate determinants equally or unequally between daughter cells, are essential for the realization of oriented cell division. Furthermore, oriented cell division is regulated by intrinsic cues, extrinsic cues and other cues, such as cell geometry and polarity. However, dysregulation of cell division orientation could lead to abnormal tissue development and function. In the present study, we review recent studies on the molecular mechanism of cell division orientation and explain their new roles in skin repair and regeneration. PMID:26582817

  4. THE WESTERN ECOLOGY DIVISION STUDENT INTERN PROGRAM VIDEO

    EPA Science Inventory

    The Western Ecology Division of the National Health & Environmental Effects Research Laboratory has produced a 15 minute video documenting the internship program at the Division. The video highlights various CWEST student interns reporting on their experiences at an end-of-the-s...

  5. "American Gothic" and the Division of Labor.

    ERIC Educational Resources Information Center

    Saunders, Robert J.

    1987-01-01

    Provides historical review of gender-based division of labor. Argues that gender-based division of labor served a purpose in survival of tribal communities but has lost meaning today and may be a handicap to full use of human talent and ability in the arts. There is nothing in various art forms which make them more appropriate for males or…

  6. Division and dynamic morphology of plastids.

    PubMed

    Osteryoung, Katherine W; Pyke, Kevin A

    2014-01-01

    Plastid division is fundamental to the biology of plant cells. Division by binary fission entails the coordinated assembly and constriction of four concentric rings, two internal and two external to the organelle. The internal FtsZ ring and external dynamin-like ARC5/DRP5B ring are connected across the two envelopes by the membrane proteins ARC6, PARC6, PDV1, and PDV2. Assembly-stimulated GTPase activity drives constriction of the FtsZ and ARC5/DRP5B rings, which together with the plastid-dividing rings pull and squeeze the envelope membranes until the two daughter plastids are formed, with the final separation requiring additional proteins. The positioning of the division machinery is controlled by the chloroplast Min system, which confines FtsZ-ring formation to the plastid midpoint. The dynamic morphology of plastids, especially nongreen plastids, is also considered here, particularly in relation to the production of stromules and plastid-derived vesicles and their possible roles in cellular communication and plastid functionality.

  7. Cadmium ecophysiology in seven stonefly (Plecoptera) species: Delineating sources and estimating susceptibility

    USGS Publications Warehouse

    Martin, C.A.; Luoma, S.N.; Cain, D.J.; Buchwalter, D.B.

    2007-01-01

    A major challenge in ecotoxicology lies in generating data under experimental conditions that are relevant to understanding contaminant effects in nature. Biodynamic modeling combines species-specific physiological traits to make predictions of metal bioaccumulation that fare well when tested in the field. We generated biodynamic models for seven predatory stonefly (Plecoptera) species representing the families Perlidae (5) and Perlodidae (2). Each taxon was exposed to cadmium independently via diet and via solution. Species varied approximately 2.6 fold in predicted steady-state cadmium concentrations. Diet was the predominant source of accumulated cadmium in five of the seven species and averaged 53.2 ?? 9.6% and 90.2 ?? 3.7% of net Cd accumulation in perlids and perlodids, respectively. Differences in Cd bioaccumulation between the two families were largely driven by differences in dissolved accumulation rates, which were considerably slower in perlodids than in perlids. We further examined the subcellular compartmentalization of Cd accumulated from independent aqueous and dietary exposures. Predicted steady-state concentrations were modified to only consider Cd accumulated in metal-sensitive subcellular compartments. These values ranged 5.3 fold. We discuss this variability within a phylogenetic context and its implications for bioassessment. ?? 2007 American Chemical Society.

  8. Measurement and modeling of polychlorinated biphenyl bioaccumulation from sediment for the marine polychaete neanthes arenaceodentata and response to sorbent amendment

    USGS Publications Warehouse

    Janssen, E.M.-L.; Croteau, M.-N.; Luoma, S.N.; Luthy, R.G.

    2010-01-01

    Bioaccumulation rates of polychlorinated biphenyls (PCBs) for the marine polychaete Neanthes arenaceodentata were characterized, including PCB uptake rates from water and sediment, and the effect of sorbent amendment to the sediment on PCB bioavailability, organism growth, and lipid content. Physiological parameters were incorporated into a biodynamic model to predict contaminant uptake. The results indicate rapid PCB uptake from contaminated sediment and significant organism growth dilution during time-series exposure studies. PCB uptake from the aqueous phase accounted for less than 3% of the total uptake for this deposit-feeder. Proportional increase of gut residence time and assimilation efficiency as a consequence of the organism's growth was assessed by PCB uptake and a reactor theory model of gut architecture. Pulse-chase feeding and multilabeled stable isotope tracing techniques proved high sediment ingestion rates (i.e., 6?10 times of dry body weight per day) indicating that such deposit-feeders are promising biological indicators for sediment risk assessment. Activated carbon amendment reduced PCB uptake by 95% in laboratory experiments with no observed adverse growth effects on the marine polychaete. Biodynamic modeling explained the observed PCB body burdens for N. arenaceodentata, with and without sorbent amendment. ?? 2009 American Chemical Society.

  9. Cell division plane orientation based on tensile stress in Arabidopsis thaliana

    PubMed Central

    Louveaux, Marion; Julien, Jean-Daniel; Mirabet, Vincent; Boudaoud, Arezki; Hamant, Olivier

    2016-01-01

    Cell geometry has long been proposed to play a key role in the orientation of symmetric cell division planes. In particular, the recently proposed Besson–Dumais rule generalizes Errera’s rule and predicts that cells divide along one of the local minima of plane area. However, this rule has been tested only on tissues with rather local spherical shape and homogeneous growth. Here, we tested the application of the Besson–Dumais rule to the divisions occurring in the Arabidopsis shoot apex, which contains domains with anisotropic curvature and differential growth. We found that the Besson–Dumais rule works well in the central part of the apex, but fails to account for cell division planes in the saddle-shaped boundary region. Because curvature anisotropy and differential growth prescribe directional tensile stress in that region, we tested the putative contribution of anisotropic stress fields to cell division plane orientation at the shoot apex. To do so, we compared two division rules: geometrical (new plane along the shortest path) and mechanical (new plane along maximal tension). The mechanical division rule reproduced the enrichment of long planes observed in the boundary region. Experimental perturbation of mechanical stress pattern further supported a contribution of anisotropic tensile stress in division plane orientation. Importantly, simulations of tissues growing in an isotropic stress field, and dividing along maximal tension, provided division plane distributions comparable to those obtained with the geometrical rule. We thus propose that division plane orientation by tensile stress offers a general rule for symmetric cell division in plants. PMID:27436908

  10. Publications - AR 2005 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Publications Geologic Materials Center General Information Inventory Monthly Report Hours and Location Policy Report Authors: DGGS Staff Publication Date: Feb 2006 Publisher: Alaska Division of Geological & Geological & Geophysical Surveys Annual Report: Alaska Division of Geological & Geophysical Surveys

  11. Publications - AR 2009 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Publications Geologic Materials Center General Information Inventory Monthly Report Hours and Location Policy Report Authors: DGGS Staff Publication Date: Jan 2010 Publisher: Alaska Division of Geological & Geological & Geophysical Surveys Annual Report: Alaska Division of Geological & Geophysical Surveys

  12. Evolutionary dynamics of division of labor games with selfish agents

    NASA Astrophysics Data System (ADS)

    Zhang, Jianlei; Li, Qiaoyu; Zhang, Chunyan

    2017-11-01

    The division of labor is one of the most basic and widely studied aspects of collective behavior in natural systems. Studies of division of labor are concerned with the integration of the individual worker behavior into a colony level task organization and with the question of how the regulation of the division of labor may contribute to the colony efficiency. This paper investigates the evolution of the division of labor with three strategies by employing the evolutionary game theory. Thus, these available strategies are, respectively, strategy A (performing task A), strategy B (performing task B), and strategy D (not performing any task but only free riding others' contributions). And, two typical networks (i.e., BA scale-free network and lattice network) are employed here for describing the interaction structure among agents. The theoretical analysis together with simulation results reveal that the division of labor can evolve and leads to players that differ in their tendency to take on a given task. The conditions under which the division of labor evolves depend on the costs for performing the task, the benefits led by performing the task, and the interaction structures among the players who are involved with division of labor games.

  13. 75 FR 36067 - Agency Information Collection Activities; Proposed Collection; Comment Request; Chemical-Specific...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-06-24

    ... section 8(a) to evaluate the potential for adverse human health and environmental effects caused by the... Office (7407M), Office of Pollution Prevention and Toxics (OPPT), Environmental Protection Agency, 1200... technical information contact: Karen Chu, Chemical Control Division (7405M), Office of Pollution Prevention...

  14. The Effect of Microplastic on the Uptake of Chemicals by the Lugworm Arenicola marina (L.) under Environmentally Relevant Exposure Conditions

    PubMed Central

    2017-01-01

    It has been hypothesized that ingestion of microplastic increases exposure of aquatic organisms to hydrophobic contaminants. To date, most laboratory studies investigated chemical transfer from ingested microplastic without taking other exposure pathways into account. Therefore, we studied the effect of polyethylene (PE) microplastic in sediment on PCB uptake by Arenicola marina as a model species, quantifying uptake fluxes from all natural exposure pathways. PCB concentrations in sediment, biota lipids (Clip) and porewater measured with passive samplers were used to derive lipid-normalized bioaccumulation metrics Clip, Biota sediment accumulation factor (BSAF), Bioaccumulation factor (BAF) and the Biota plastic accumulation factor (BPAF). Small effects of PE addition were detected suggesting slightly increased or decreased bioaccumulation. However, the differences decreased in magnitude dependent on the metric used to assess bioaccumulation, in the order: Clip > BSAF > BPAF > BAF, and were nonsignificant for BAF. The fact that BAF, that is, normalization of Clip on porewater concentration, largely removed all effects of PE, shows that PE did not act as a measurable vector of PCBs. Biodynamic model analysis confirmed that PE ingestion contributed marginally to bioaccumulation. This work confirmed model-based predictions on the limited relevance of microplastic for bioaccumulation under environmentally realistic conditions, and illustrated the importance of assessing exposure through all media in microplastic bioaccumulation studies. PMID:28682597

  15. Life Sciences Division annual report, 1988

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Marrone, B.L.; Cram, L.S.

    1989-04-01

    This report summarizes the research and development activities of Los Alamos National Laboratory's Life Sciences Division for the calendar year 1988. Technical reports related to the current status of projects are presented in sufficient detail to permit the informed reader to assess their scope and significance. Summaries useful to the casual reader desiring general information have been prepared by the Group Leaders and appear in each group overview. Investigators on the staff of the Life Sciences Division will be pleased to provide further information.

  16. Publications - AR 2006 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2006 main content DGGS AR 2006 Publication Details Title: Alaska Division of Geological & Geophysical Surveys Annual

  17. Publications - AR 2000 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2000 main content DGGS AR 2000 Publication Details Title: Alaska Division of Geological & Geophysical Surveys Annual

  18. Publications - AR 2003 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2003 main content DGGS AR 2003 Publication Details Title: Alaska Division of Geological & Geophysical Surveys Annual

  19. Publications - AR 2004 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2004 main content DGGS AR 2004 Publication Details Title: Alaska Division of Geological & Geophysical Surveys Annual

  20. Publications - GMC 267 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a well materials Authors: Unknown Publication Date: 1996 Publisher: Alaska Division of Geological & Alaska North Slope well materials: Alaska Division of Geological & Geophysical Surveys Geologic

  1. 78 FR 49111 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-13

    ... Airworthiness Directives; Pratt & Whitney Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA... & Whitney Division (PW) turbofan engine model PW4074, PW4074D, PW4077, PW4077D, PW4084D, PW4090, and PW4090...) Applicability This AD applies to all Pratt & Whitney Division (PW) turbofan engine models PW4074, PW4074D...

  2. Fighting Divisions

    DTIC Science & Technology

    1945-12-01

    secure several passes in the Vosges Mountains. It hadn’t been committed to battle long before it learned a severe lesson in what war can be like at its...for the first time enough material on every one of our divisions to give the average citizen a brief idea of where each has been and what each has...considered both the advisability and desirability of immediately releasing accounts of impressive battle achievements to Ameri- can citizens at home so

  3. Cell Division and Evolution of Biological Tissues

    NASA Astrophysics Data System (ADS)

    Rivier, Nicolas; Arcenegui-Siemens, Xavier; Schliecker, Gudrun

    A tissue is a geometrical, space-filling, random cellular network; it remains in this steady state while individual cells divide. Cell division (fragmentation) is a local, elementary topological transformation which establishes statistical equilibrium of the structure. Statistical equilibrium is characterized by observable relations (Lewis, Aboav) between cell shapes, sizes and those of their neighbours, obtained through maximum entropy and topological correlation extending to nearest neighbours only, i.e. maximal randomness. For a two-dimensional tissue (epithelium), the distribution of cell shapes and that of mother and daughter cells can be obtained from elementary geometrical and physical arguments, except for an exponential factor favouring division of larger cells, and exponential and combinatorial factors encouraging a most symmetric division. The resulting distributions are very narrow, and stationarity severely restricts the range of an adjustable structural parameter

  4. Actor Networks and the Division of Knowledge in the University.

    ERIC Educational Resources Information Center

    Busch, Lawrence

    This paper discusses the current division of knowledge at the college and university level, its historical roots, and the application of Actor Network Theory (ANT) to arrive at an explanation of the permanence of the current division of knowledge as well as what form a new division of knowledge might take. It finds fragmentation and disintegration…

  5. Division of labour and the evolution of extreme specialization.

    PubMed

    Cooper, Guy A; West, Stuart A

    2018-05-28

    Division of labour is a common feature of social groups, from biofilms to complex animal societies. However, we lack a theoretical framework that can explain why division of labour has evolved on certain branches of the tree of life but not others. Here, we model the division of labour over a cooperative behaviour, considering both when it should evolve and the extent to which the different types should become specialized. We found that: (1) division of labour is usually-but not always-favoured by high efficiency benefits to specialization and low within-group conflict; and (2) natural selection favours extreme specialization, where some individuals are completely dependent on the helping behaviour of others. We make a number of predictions, several of which are supported by the existing empirical data, from microbes and animals, while others suggest novel directions for empirical work. More generally, we show how division of labour can lead to mutual dependence between different individuals and hence drive major evolutionary transitions, such as those to multicellularity and eusociality.

  6. Publications - GMC 87 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    : Unknown Publication Date: 1988 Publisher: Alaska Division of Geological & Geophysical Surveys Total . Bibliographic Reference Unknown, 1988, Capillary pressure test data for 14 North Slope wells: Alaska Division of

  7. Publications - GMC 119 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a (Corona) well Authors: Unknown Publication Date: 1989 Publisher: Alaska Division of Geological & from OCS Y-0871-1 (Corona) well: Alaska Division of Geological & Geophysical Surveys Geologic

  8. A novel cell division factor from tobacco 2B-13 cells that induced cell division in auxin-starved tobacco BY-2 cells

    NASA Astrophysics Data System (ADS)

    Shimizu, Takashi; Eguchi, Kentaro; Nishida, Ikuo; Laukens, Kris; Witters, Erwin; van Onckelen, Harry; Nagata, Toshiyuki

    2006-06-01

    Effects of auxin as plant hormones are widespread; in fact in almost all aspects of plant growth and development auxin plays a pivotal role. Although auxin is required for propagating cell division in plant cells, its effect upon cell division is least understood. If auxin is depleted from the culture medium, cultured cells cease to divide. It has been demonstrated in this context that the addition of auxin to auxin-starved nondividing tobacco BY-2 cells induced semisynchronous cell division. On the other hand, there are some cell lines, named habituated cells, that can grow without auxin. The cause and reason for the habituated cells have not been clarified. A habituated cell line named 2B-13 is derived from the tobacco BY-2 cell line, which has been most intensively studied among plant cell lines. When we tried to find the difference between two cell lines of BY-2 and 2B-13 cells, we found that the addition of culture filtrated from the auxin-habituated 2B-13 cells induced semisynchronous cell division in auxin-starved BY-2 cells. The cell division factor (CDF) that is responsible for inducing cell division in auxin-starved BY-2 cells was purified to near-homogeneity by sequential passage through a hydroxyapatite column, a ConA Sepharose column and a Sephadex gel filtration column. The resulting purified fraction appeared as a single band of high molecular weight on sodium dodecyl sulfate-polyacrylamide gel electrophoresis gels by silver staining and was able to induce cell division in auxin-starved BY-2 cells. Identification of the protein by MALD-TOF-MS/MS revealed that it is structurally related to P-glycoprotein from Gossypioides kirkii, which belongs to ATP-binding cassette (ABC)-transporters. The significance of CDF as a possible ABC-transporter is discussed in relationship to auxin-autotrophic growth and auxin-signaling pathway.

  9. What Does Division Mean?

    ERIC Educational Resources Information Center

    Burton, Grace M.; Knifong, J. Dan

    1983-01-01

    Models for division are discussed: counting, repeated subtraction, inverse of multiplication, sets, number line, balance beam, arrays, and cross product of sets. Expressing the remainder using various models is then presented, followed by comments on why all the models should be taught. (MNS)

  10. Alaska Department of Revenue - Tax Division - Charitable Gaming Page

    Science.gov Websites

    Alaska Web Site? Tax State of Alaska Tax Types Forms Reports Online Services About Tax Alaska Department of Revenue - Tax Division Department of Revenue > Tax Division > Tax Types > Charitable

  11. A biodynamic understanding of dietborne and waterborne Ag uptake from Ag NPs in the sediment-dwelling oligochaete, Tubifex tubifex

    USGS Publications Warehouse

    Tangaa, Stine Rosendal; Winther-Nielsen, Margrethe; Selck, Henriette; Croteau, Marie-Noele

    2018-01-01

    Metal nanoparticles (Me-NPs) are increasingly used in various products, such as inks and cosmetics, enhancing the likelihood of their release into aquatic environments. An understanding of the mechanisms controlling their bioaccumulation and ecotoxicity in aquatic biota will help support environmental risk assessment. Here we characterized unidirectional parameters for uptake and elimination of silver (Ag) in the sediment-dwelling oligochaete Tubifex tubifex after waterborne (0.01–47 nmol Ag/L) and dietborne (0.4–482 nmol Ag/g dw sed.) exposures to Ag NPs and AgNO3, respectively. Worms accumulated Ag from AgNO3more efficiently than from Ag NPs during waterborne exposure. The Ag uptake rate constants from water were 8.2 L/g/d for AgNO3 and 0.34 L/g/d for Ag NPs. Silver accumulated from both forms was efficiently retained in tissues, as no significant loss of Ag was detected after up to 20 days of depuration in clean media. High mortality (~50%) during depuration (i.e. after 17 days) was only observed for worms exposed to waterborne AgNO3 (3 nmol/L). Sediment exposures to both Ag forms resulted in low accumulation, i.e., the uptake rate constants were 0.002 and 0.005 g/g/d for AgNO3 and Ag NPs, respectively. Avoidance was only observed for worms exposed to sediment amended with AgNO3. Incorporation of the estimated rate constants into a biodynamic model predicted that sediment is likely the most important route of uptake for Ag in both forms in ecologically relevant aquatic environments. However, inference of bioavailability from our estimations of Ag assimilation efficiencies (AE) suggests that Ag (AE: 3–12% for AgNO3 and 0.1–0.8% for Ag NPs) is weakly bioavailable from sediment for this species. Thus, Ag amended to sediment as NPs might not pose greater problems than 'conventional' Ag for benthic organisms such as T. tubifex.

  12. BYSTANDER EFFECTS GENOMIC INSTABILITY, ADAPTIVE RESPONSE AND CANCER RISK ASSESSMENT FOR RADIAION AND CHEMICAL EXPOSURES

    EPA Science Inventory

    BYSTANDER EFFECTS, GENOMIC INSTABILITY, ADAPTIVE RESPONSE AND CANCER RISK ASSESSMENT FOR RADIATION AND CHEMICAL EXPOSURES

    R. Julian Preston
    Environmental Carcinogenesis Division, U.S. Environmental Protection Agency, Research Triangle Park, N.C. 27711, USA

    There ...

  13. Linking performance benchmarking of refinery process chemicals to refinery key performance indicators

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Cook, J.M.; Nieman, L.D.

    In 1977 Solomon Associates, Inc. issued its first study of refining in the US entitled, Comparative Performance Analysis for Fuel Product Refineries, most commonly referred to as the Solomon Study, or the Fuels Study. In late 1993, both the Water and Waste Water Management, and Petroleum Divisions of Nalco Chemical Company came to the same conclusion; that they must have a better understanding of the Solomon Study process, and have some input to this system of measurement. The authors first approached Solomon Associates with the idea that a specific study should be done of specialty chemicals used in the refinery.more » They felt that this would result in two studies, one for water treatment applications, and one for process. The water treatment study came first, and was completed in 1993 with the United States Petroleum Refineries Water Treatment Performance Analysis for Operating Year 1993. The process study, entitled United States Petroleum Refinery Process Treatment Performance Analysis for Operating Years 1994--95 will be issued in the 2nd quarter of this year by Nalco/Exxon Energy Chemicals, L.P, which includes the combined resources of the former Petroleum Division of Nalco Chemical Company (including the petroleum related portions of most of its overseas companies), and the petroleum related specialty chemical operations of Exxon Chemical on a global basis. What follows is a recap of the process study focus, some examples of output, and comment on both the linkage to key refinery operating indicators, as well as the perception of the effect of such measurement on the supplier relationship of the future.« less

  14. Publications - GMC 162 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a Unit Zappa #1 well Authors: Unknown Publication Date: 1990 Publisher: Alaska Division of Geological the Alaska Consolidated Oil Iniskin Unit Zappa #1 well: Alaska Division of Geological &

  15. Alaska Department of Revenue - Tax Division - License Search Page

    Science.gov Websites

    Alaska Web Site? Tax State of Alaska Tax Types Forms Reports Online Services About Tax Alaska Department of Revenue - Tax Division Department of Revenue > Tax Division > Tax Types > Search Permits

  16. A Survey of Industrial Organic Chemists: Understanding the Chemical Industry's Needs of Current Bachelor-Level Graduates

    ERIC Educational Resources Information Center

    Fair, Justin D.; Kleist, Elyse M.; Stoy, Dylan M.

    2014-01-01

    A survey was conducted of companies from the chemical industry with an emphasis on the organic division. The data include results from 377 respondents from more than 100 different companies. More than half of all undergraduates gain fulltime work in the chemical industry or government after graduating with a bachelor's degree in chemistry.…

  17. Perspectives on communicating risks of chemicals.

    PubMed

    Armbrust, Kevin; Burns, Mitchell; Crossan, Angus N; Fischhoff, David A; Hammond, Larry E; Johnston, John J; Kennedy, Ivan; Rose, Michael T; Seiber, James N; Solomon, Keith

    2013-05-22

    The Agrochemicals Division symposium "Perfecting Communication of Chemical Risk", held at the 244th National Meeting and Exposition of the American Chemical Society in Philadelphia, PA, August 19-23, 2012, is summarized. The symposium, organized by James Seiber, Kevin Armbrust, John Johnston, Ivan Kennedy, Thomas Potter, and Keith Solomon, included discussion of better techniques for communicating risks, lessons from past experiences, and case studies, together with proposals to improve these techniques and their communication to the public as effective information. The case studies included risks of agricultural biotechnology, an organoarsenical (Roxarsone) in animal feed, petroleum spill-derived contamination of seafood, role of biomonitoring and other exposure assessment techniques, soil fumigants, implications of listing endosulfan as a persistant organic pollutant (POP), and diuron herbicide in runoff, including use of catchment basins to limit runoff to coastal ecozones and the Great Barrier Reef. The symposium attracted chemical risk managers including ecotoxicologists, environmental chemists, agrochemists, ecosystem managers, and regulators needing better techniques that could feed into better communication of chemical risks. Policy issues related to regulation of chemical safety as well as the role of international conventions were also presented. The symposium was broadcast via webinar to an audience outside the ACS Meeting venue.

  18. The Astrophysics Science Division Annual Report 2008

    NASA Technical Reports Server (NTRS)

    Oegerle, William; Reddy, Francis; Tyler, Pat

    2009-01-01

    The Astrophysics Science Division (ASD) at Goddard Space Flight Center (GSFC) is one of the largest and most diverse astrophysical organizations in the world, with activities spanning a broad range of topics in theory, observation, and mission and technology development. Scientific research is carried out over the entire electromagnetic spectrum from gamma rays to radio wavelengths as well as particle physics and gravitational radiation. Members of ASD also provide the scientific operations for three orbiting astrophysics missions WMAP, RXTE, and Swift, as well as the Science Support Center for the Fermi Gamma-ray Space Telescope. A number of key technologies for future missions are also under development in the Division, including X-ray mirrors, and new detectors operating at gamma-ray, X-ray, ultraviolet, infrared, and radio wavelengths. This report includes the Division's activities during 2008.

  19. Publications - SR 64 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    , L.A., and Hughes, R.A. Publication Date: Dec 2010 Publisher: Alaska Division of Geological & ., Harbo, L.A., and Hughes, R.A., 2010, Alaska's mineral industry 2009: Alaska Division of Geological &

  20. Publications - GMC 239 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a Conoco Inc. Sequoia #1 well Authors: Unknown Publication Date: 1994 Publisher: Alaska Division of from cuttings (1,700-8,190') of the Conoco Inc. Sequoia #1 well: Alaska Division of Geological &

  1. Publications - GMC 132 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a . Kustatan River #1 well Authors: Edison, T.A. Publication Date: 1989 Publisher: Alaska Division of data of cuttings from the Shell Oil Co. Kustatan River #1 well: Alaska Division of Geological &

  2. Publications - GMC 258 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ARCO Alaska Inc. Kuukpik #3 well Authors: Unknown Publication Date: 1995 Publisher: Alaska Division of from cuttings (3,220-6,570') of the ARCO Alaska Inc. Kuukpik #3 well: Alaska Division of Geological

  3. Division of Public Health

    Science.gov Websites

    State Employees Public Health DHSS State of Alaska Home Divisions and Agencies Alaska Pioneer Homes Behavioral Health Office of Children's Services Office of the Commissioner Office of Substance Misuse and Addiction Prevention Finance & Management Services Health Care Services Juvenile Justice Public

  4. Wavefront division digital holography

    NASA Astrophysics Data System (ADS)

    Zhang, Wenhui; Cao, Liangcai; Li, Rujia; Zhang, Hua; Zhang, Hao; Jiang, Qiang; Jin, Guofan

    2018-05-01

    Digital holography (DH), mostly Mach-Zehnder configuration based, belongs to non-common path amplitude splitting interference imaging whose stability and fringe contrast are environmental sensitive. This paper presents a wavefront division DH configuration with both high stability and high-contrast fringes benefitting from quasi common path wavefront-splitting interference. In our proposal, two spherical waves with similar curvature coming from the same wavefront are used, which makes full use of the physical sampling capacity of the detectors. The interference fringe spacing can be adjusted flexibly for both in-line and off-axis mode due to the independent modulation to these two waves. Only a few optical elements, including the mirror-beam splitter interference component, are used without strict alignments, which makes it robust and easy-to-implement. The proposed wavefront division DH promotes interference imaging physics into the practical and miniaturized a step forward. The feasibility of this method is proved by the imaging of a resolution target and a water flea.

  5. Division of Biological and Medical Research annual technical report 1982

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rosenthal, M.W.

    1983-05-01

    This report summarizes research during 1982 in the Division of Biological and Medical Research, Argonne National Laboratory. Studies in Carcinogenesis address mechanisms of chemical and radiation carcinogenesis including the processes of tumor initiation and promotion. The studies employ rat liver and mouse skin models as well as human rodent cell culture systems. The use of liposomes for metal mobilization is also explored. Low Level Radiation studies include delineation of the hematopoietic and other responses of dogs to continuous low level gamma irradiation, comparison of lifetime effects in mice of low level neutron and gamma irradiation, and study of the geneticmore » effects of high LET radiation. Molecular Biology research develops two-dimensional electrophoresis systems for diagnosis and detection of cancer and other diseases. Fundamental structural and biophysical investigations of immunoglobulins and other key proteins are included, as are studies of cell growth, and of molecular and cellular effects of solar uv light. Research in Toxicology uses cellular, physiological, whole animal, and chronobiological end points and chemical separations to elucidate mechanisms and evaluate hazards of coal conversion by-products, actinides, and toxic metals. The final sections cover support facilities, educational activities, seminars, staff talks, staff, and funding agencies.« less

  6. 9 CFR 112.4 - Subsidiaries, divisions, distributors, and permittees.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... relationship of the division or marketing unit to the licensee shall appear prominently on the label by use of... distribution by a division or marketing unit of the licensee shall be submitted in accordance with § 112.5. The...

  7. Publications - GMC 254 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ARCO Alaska Inc. Cirque #2 well Authors: Unknown Publication Date: 1995 Publisher: Alaska Division of from cuttings (2,200-7,660') of the ARCO Alaska Inc. Cirque #2 well: Alaska Division of Geological &

  8. Publications - GMC 139 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a . OCS Y-0113-1 (Ibis #1) well Authors: Unknown Publication Date: 1989 Publisher: Alaska Division of of cuttings from the Arco Alaska Inc. OCS Y-0113-1 (Ibis #1) well: Alaska Division of Geological &

  9. Publications - GMC 255 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ARCO Alaska Inc. Rock Flour #1 well Authors: Unknown Publication Date: 1995 Publisher: Alaska Division reflectance data from cuttings (1,600-7,170') of the ARCO Alaska Inc. Rock Flour #1 well: Alaska Division of

  10. Publications - GMC 238 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ARCO Alaska Inc. Fiord #1 well Authors: Unknown Publication Date: 1994 Publisher: Alaska Division of from cuttings (1,250-10,250') of the ARCO Alaska Inc. Fiord #1 well: Alaska Division of Geological &

  11. Publications - GMC 177 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a . Navy Umiat Test Well #11 Authors: Bujak Davies Group Publication Date: 1990 Publisher: Alaska Division , Palynological analysis of core (342.9'-1037') from the U.S. Navy Umiat Test Well #11: Alaska Division of

  12. Publications - GMC 410 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    ) Keywords Geochemistry; Rare Earth Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  13. Publications - GMC 409 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    ) Keywords Geochemistry; Rare Earth Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  14. Publications - GMC 397 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    : Apache Corp., Alaska Division of Oil and Gas, and Weatherford Laboratories Publication Date: Nov 2011 Apache Corp., Alaska Division of Oil and Gas, and Weatherford Laboratories, 2011, Porosity and Files gmc397.pdf (2.8 M) gmc397.zip (24.2 M) Keywords Cook Inlet Basin; Oil and Gas; Permeability

  15. Joy Osborne, MS, MPA | Division of Cancer Prevention

    Cancer.gov

    Joy Osborne is the ARC Director for the Division of Cancer Prevention and the Division of Cancer Control and Population Sciences. The ARC (Administrative Resource Center) provides services to DCP in the areas of budget, contracts, grants, human resources, travel, space and facilities, and other administrative areas. Joy came to NCI in 1992 as a Presidential Management Intern

  16. Mentorship programs for faculty development in academic general pediatric divisions.

    PubMed

    Takagishi, Jennifer; Dabrow, Sharon

    2011-01-01

    Introduction. Mentoring relationships have been shown to support academicians in areas of research, work/life balance, and promotion. Methods. General pediatric division chiefs accessed an electronic survey asking about mentorship relationships, their ability to create a mentorship program, and resources needed. Results. Dyadic mentorship programs were available at 53% of divisions. Peer mentorship programs were available at 27% of divisions. Overall, 84% of chiefs believed that dyadic mentorship would benefit their faculty. 91% of chiefs believed that peer mentorship would benefit their faculty. Chiefs were interested in starting peer (57%) or dyadic (55%) mentorship programs. Few divisions had a peer mentorship program available, whereas 24% already had a dyadic program. 43% of chiefs felt that they had the tools to start a program. Many tools are needed to create a program. Discussion. General pediatric division chiefs acknowledge the benefits of mentoring relationships, and some have programs in place. Many need tools to create them. Pediatric societies could facilitate this critical area of professional development.

  17. Stationary Size Distributions of Growing Cells with Binary and Multiple Cell Division

    NASA Astrophysics Data System (ADS)

    Rading, M. M.; Engel, T. A.; Lipowsky, R.; Valleriani, A.

    2011-10-01

    Populations of unicellular organisms that grow under constant environmental conditions are considered theoretically. The size distribution of these cells is calculated analytically, both for the usual process of binary division, in which one mother cell produces always two daughter cells, and for the more complex process of multiple division, in which one mother cell can produce 2 n daughter cells with n=1,2,3,… . The latter mode of division is inspired by the unicellular algae Chlamydomonas reinhardtii. The uniform response of the whole population to different environmental conditions is encoded in the individual rates of growth and division of the cells. The analytical treatment of the problem is based on size-dependent rules for cell growth and stochastic transition processes for cell division. The comparison between binary and multiple division shows that these different division processes lead to qualitatively different results for the size distribution and the population growth rates.

  18. Mechanical stretch triggers rapid epithelial cell division through Piezo1.

    PubMed

    Gudipaty, S A; Lindblom, J; Loftus, P D; Redd, M J; Edes, K; Davey, C F; Krishnegowda, V; Rosenblatt, J

    2017-03-02

    Despite acting as a barrier for the organs they encase, epithelial cells turn over at some of the fastest rates in the body. However, epithelial cell division must be tightly linked to cell death to preserve barrier function and prevent tumour formation. How does the number of dying cells match those dividing to maintain constant numbers? When epithelial cells become too crowded, they activate the stretch-activated channel Piezo1 to trigger extrusion of cells that later die. However, it is unclear how epithelial cell division is controlled to balance cell death at the steady state. Here we show that mammalian epithelial cell division occurs in regions of low cell density where cells are stretched. By experimentally stretching epithelia, we find that mechanical stretch itself rapidly stimulates cell division through activation of the Piezo1 channel. To stimulate cell division, stretch triggers cells that are paused in early G2 phase to activate calcium-dependent phosphorylation of ERK1/2, thereby activating the cyclin B transcription that is necessary to drive cells into mitosis. Although both epithelial cell division and cell extrusion require Piezo1 at the steady state, the type of mechanical force controls the outcome: stretch induces cell division, whereas crowding induces extrusion. How Piezo1-dependent calcium transients activate two opposing processes may depend on where and how Piezo1 is activated, as it accumulates in different subcellular sites with increasing cell density. In sparse epithelial regions in which cells divide, Piezo1 localizes to the plasma membrane and cytoplasm, whereas in dense regions in which cells extrude, it forms large cytoplasmic aggregates. Because Piezo1 senses both mechanical crowding and stretch, it may act as a homeostatic sensor to control epithelial cell numbers, triggering extrusion and apoptosis in crowded regions and cell division in sparse regions.

  19. Investigation into constant envelope orthogonal frequency division multiplexing for polarization-division multiplexing coherent optical communication

    NASA Astrophysics Data System (ADS)

    Li, Yupeng; Ding, Ding

    2017-09-01

    Benefiting from the high spectral efficiency and low peak-to-average power ratio, constant envelope orthogonal frequency division multiplexing (OFDM) is a promising technique in coherent optical communication. Polarization-division multiplexing (PDM) has been employed as an effective way to double the transmission capacity in the commercial 100 Gb/s PDM-QPSK system. We investigated constant envelope OFDM together with PDM. Simulation results show that the acceptable maximum launch power into the fiber improves 10 and 6 dB for 80- and 320-km transmission, respectively (compared with the conventional PDM OFDM system). The maximum reachable distance of the constant envelope OFDM system is able to reach 800 km, and even 1200 km is reachable if an ideal erbium doped fiber amplifier is employed.

  20. Meiotic Divisions: No Place for Gender Equality.

    PubMed

    El Yakoubi, Warif; Wassmann, Katja

    2017-01-01

    In multicellular organisms the fusion of two gametes with a haploid set of chromosomes leads to the formation of the zygote, the first cell of the embryo. Accurate execution of the meiotic cell division to generate a female and a male gamete is required for the generation of healthy offspring harboring the correct number of chromosomes. Unfortunately, meiosis is error prone. This has severe consequences for fertility and under certain circumstances, health of the offspring. In humans, female meiosis is extremely error prone. In this chapter we will compare male and female meiosis in humans to illustrate why and at which frequency errors occur, and describe how this affects pregnancy outcome and health of the individual. We will first introduce key notions of cell division in meiosis and how they differ from mitosis, followed by a detailed description of the events that are prone to errors during the meiotic divisions.

  1. Family division in China’s transitional economy

    PubMed Central

    Chen, Feinian

    2009-01-01

    Using a longitudinal data-set (the China Health and Nutrition Survey) we explored the effect of various economic factors, including household wealth, employment sector, and involvement in a household business on the division of extended families in China’s transitional economy. Results from event history analyses suggest that these economic factors act as either a dividing or a unifying force on the extended family. Household wealth reduces the risk of family division, but the effect is weaker for families in which parents have upper secondary education. In addition, an extended family is more likely to divide when married children work in the state sector. Further, the probability of family division is higher in families where daughters-in-law work in the state sector than in those with sons in this sector. Finally, involvement in a household business for married children increases family stability. PMID:19184721

  2. 3. Perspective view of Express Building looking northeast, with Division ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    3. Perspective view of Express Building looking northeast, with Division Street in foreground - American Railway Express Company Freight Building, 1060 Northeast Division Street, Bend, Deschutes County, OR

  3. Ploidy-Dependent Unreductional Meiotic Cell Division in Polyploid Wheat

    USDA-ARS?s Scientific Manuscript database

    Meiosis includes one round of DNA replication and two successive nuclear divisions, i.e. meiosis I (reductional) and meiosis II (equational). This specialized cell division reduces chromosomes in half and generates haploid gametes in sexual reproduction of eukaryotes. It ensures faithful transmiss...

  4. Fire prevention in the California Division of Forestry. . .personnel and practices

    Treesearch

    Adam Sarapata; William S. Folkman

    1970-01-01

    A sample of California Division of Forestry employees whose jobs include some contact with the public were queried about job satisfaction and employee motivations, and their responses were related to the Division's fire prevention program. Most respondents felt that Division management considered the program less important than fire suppression and detection. They...

  5. HEP Division Argonne National Laboratory

    Science.gov Websites

    Design Neutrino Physics Theoretical Physics Seminars HEP Division Seminar HEP Lunch Seminar HEP Theory administrators theory users trice users HEP webmaster U.S. Department of Energy Office of Science | UChicago

  6. The 4th Armored Division in the Encirclement of Nancy.

    DTIC Science & Technology

    1986-04-01

    Germans to bar the way. The Germans sent two depleted but still dangerous mechanized infantry divi- sions, the 3d and 15th Panzergrenadier, from Italy...when the 3d Panzergrenadier Division handily repulsed a crossing of the Moselle mounted by the 80th Infantry Division on 5 September. Having been...deceived for long. At 0100 on 13 September, the 3d Panzergrenadier Division hit the Dieulouard bridgehead with a strong counterattack, causing the corps

  7. Cell division cycle 45 promotes papillary thyroid cancer progression via regulating cell cycle.

    PubMed

    Sun, Jing; Shi, Run; Zhao, Sha; Li, Xiaona; Lu, Shan; Bu, Hemei; Ma, Xianghua

    2017-05-01

    Cell division cycle 45 was reported to be overexpressed in some cancer-derived cell lines and was predicted to be a candidate oncogene in cervical cancer. However, the clinical and biological significance of cell division cycle 45 in papillary thyroid cancer has never been investigated. We determined the expression level and clinical significance of cell division cycle 45 using The Cancer Genome Atlas, quantitative real-time polymerase chain reaction, and immunohistochemistry. A great upregulation of cell division cycle 45 was observed in papillary thyroid cancer tissues compared with adjacent normal tissues. Furthermore, overexpression of cell division cycle 45 positively correlates with more advanced clinical characteristics. Silence of cell division cycle 45 suppressed proliferation of papillary thyroid cancer cells via G1-phase arrest and inducing apoptosis. The oncogenic activity of cell division cycle 45 was also confirmed in vivo. In conclusion, cell division cycle 45 may serve as a novel biomarker and a potential therapeutic target for papillary thyroid cancer.

  8. Publications - GMC 370 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    (249.0 K) Keywords Rare Earth Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  9. Developing predictions of in vivo developmental toxicity of ToxCast chemicals using mouse embryonic stem cells.

    EPA Science Inventory

    Developing predictions of in vivo developmental toxicity of ToxCast chemicals using mouse embryonic stem cells S. Hunter, M. Rosen, M. Hoopes, H. Nichols, S. Jeffay, K. Chandler1, Integrated Systems Toxicology Division, National Health and Environmental Effects Research Labor...

  10. 7. Contextual view of Fairbanks Company, looking north along Division ...

    Library of Congress Historic Buildings Survey, Historic Engineering Record, Historic Landscapes Survey

    7. Contextual view of Fairbanks Company, looking north along Division Street, showing relationship of factory to surrounding buildings and railroad - Fairbanks Company, 202 Division Street, Rome, Floyd County, GA

  11. 28 CFR 50.6 - Antitrust Division business review procedure.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 2 2010-07-01 2010-07-01 false Antitrust Division business review procedure. 50.6 Section 50.6 Judicial Administration DEPARTMENT OF JUSTICE (CONTINUED) STATEMENTS OF POLICY § 50.6 Antitrust Division business review procedure. Although the Department of Justice is not...

  12. Division 1137 property control system

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Pastor, D.J.

    1982-01-01

    An automated data processing property control system was developed by Mobile and Remote Range Division 1137. This report describes the operation of the system and examines ways of using it in operational planning and control.

  13. 75 FR 45151 - National Security Division; Agency Information Collection Activities: Proposed Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... DEPARTMENT OF JUSTICE [OMB Number 1124-0006] National Security Division; Agency Information...), National Security Division (NSD), will be submitting the following information collection request to the..., 10th & Constitution Avenue, NW., National Security Division, Counterespionage Section/Registration Unit...

  14. FtsZ ring: the eubacterial division apparatus conserved in archaebacteria.

    PubMed

    Wang, X; Lutkenhaus, J

    1996-07-01

    FtsZ is a tubulin-like protein that is essential for cell division in eubacteria. It functions by forming a ring at the division site that directs septation. The archaebacteria constitute a kingdom of life separate from eubacteria and eukaryotes. Like eubacteria, archaebacteria are prokaryotes, although they are phylogenetically closer to eukaryotes. Here it is shown that archaebacteria also possess FtsZ and that it is biochemically similar to eubacterial FtsZs. Significantly, FtsZ from the archaebacterium Haloferax volcanii is a GTPase that is localized to a ring that coincides with the division constriction. These results indicate that the FtsZ ring was part of the division apparatus of a common prokaryotic ancestor that was retained by both eubacteria and archaebacteria.

  15. Kinetics of cell division in epidermal maintenance

    NASA Astrophysics Data System (ADS)

    Klein, Allon M.; Doupé, David P.; Jones, Phillip H.; Simons, Benjamin D.

    2007-08-01

    The rules governing cell division and differentiation are central to understanding the mechanisms of development, aging, and cancer. By utilizing inducible genetic labeling, recent studies have shown that the clonal population in transgenic mouse epidermis can be tracked in vivo. Drawing on these results, we explain how clonal fate data may be used to infer the rules of cell division and differentiation underlying the maintenance of adult murine tail-skin. We show that the rates of cell division and differentiation may be evaluated by considering the long-time and short-time clone fate data, and that the data is consistent with cells dividing independently rather than synchronously. Motivated by these findings, we consider a mechanism for cancer onset based closely on the model for normal adult skin. By analyzing the expected changes to clonal fate in cancer emerging from a simple two-stage mutation, we propose that clonal fate data may provide a novel method for studying the earliest stages of the disease.

  16. On the interrelation of multiplication and division in secondary school children

    PubMed Central

    Huber, Stefan; Fischer, Ursula; Moeller, Korbinian; Nuerk, Hans-Christoph

    2013-01-01

    Multiplication and division are conceptually inversely related: Each division problem can be transformed into as a multiplication problem and vice versa. Recent research has indicated strong developmental parallels between multiplication and division in primary school children. In this study, we were interested in (i) whether these developmental parallels persist into secondary school, (ii) whether similar developmental parallels can be observed for simple and complex problems, (iii) whether skill level modulates this relationship, and (iv) whether the correlations are specific and not driven by general cognitive or arithmetic abilities. Therefore, we assessed performance of 5th and 6th graders attending two secondary school types of the German educational system in simple and complex multiplication as well as division while controlling for non-verbal intelligence, short-term memory, and other arithmetic abilities. Accordingly, we collected data from students differing in skills levels due to either age (5th < 6th grade) or school type (general < intermediate secondary school). We observed moderate to strong bivariate and partial correlations between multiplication and division with correlations being higher for simple tasks but nevertheless reliable for complex tasks. Moreover, the association between simple multiplication and division depended on students' skill levels as reflected by school types, but not by age. Partial correlations were higher for intermediate than for general secondary school children. In sum, these findings emphasize the importance of the inverse relationship between multiplication and division which persists into later developmental stages. However, evidence for skill-related differences in the relationship between multiplication and division was restricted to the differences for school types. PMID:24133476

  17. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Search MSD Go MSD - Materials Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of

  18. 75 FR 45153 - National Security Division; Agency Information Collection Activities: Proposed Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... DEPARTMENT OF JUSTICE [OMB Number 1124-0001] National Security Division; Agency Information..., 10th & Constitution Avenue, NW., National Security Division, Counterespionage Section/Registration Unit... Justice sponsoring the collection: Form Number: NSD- 1. National Security Division, U.S. Department of...

  19. | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  20. Division of Finance Homepage

    Science.gov Websites

    Search the Division of Finance site DOF State of Alaska Finance Home Content Area Accounting Charge Cards IRIS HRM Login LearnAlaska SFOA SharePoint Site Vendor Self Service (VSS) Content Area Accounting Dunayski, Accounting Services Lead Danielle Meier, State E-Travel Manager Stephanie Church, IRIS Financial

  1. The Problem with Division

    ERIC Educational Resources Information Center

    Pope, Sue

    2012-01-01

    Of the "big four", division is likely to regarded by many learners as "the odd one out", "the difficult one", "the one that is complicated", or "the scary one". It seems to have been that way "for ever", in the perception of many who have trodden the learning pathways through the world of…

  2. Publications - IC 17 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    DGGS IC 17 Publication Details Title: Coal resources of Alaska Authors: Alaska Division of Geological Statewide Bibliographic Reference Alaska Division of Geological & Geophysical Surveys, 1983, Coal Alaska Statewide Maps; Coal; Healy; Resource Assessment; Usibelli Mine Top of Page Department of Natural

  3. 1986 Division 17 Presidential Address: Crossroads for Counseling Psychology.

    ERIC Educational Resources Information Center

    Gazda, George M.

    1987-01-01

    Addresses the American Psychological Association (APA) reorganization plans developed by the Task Force on the Structure of APA, and their impact on Division 17, the Division of Counseling Psychology. Discusses accreditation, specialization, model guidelines for state licensure and graduate education. Expresses concern regarding the Assemblies'…

  4. 33 CFR 274.6 - Division/district pest control programs.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Division/district pest control..., DEPARTMENT OF DEFENSE PEST CONTROL PROGRAM FOR CIVIL WORKS PROJECTS Project Operation § 274.6 Division/district pest control programs. (a) Guides. Referenced technical manuals, and Engineer Circulars issued...

  5. 33 CFR 274.6 - Division/district pest control programs.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Division/district pest control..., DEPARTMENT OF DEFENSE PEST CONTROL PROGRAM FOR CIVIL WORKS PROJECTS Project Operation § 274.6 Division/district pest control programs. (a) Guides. Referenced technical manuals, and Engineer Circulars issued...

  6. 33 CFR 274.6 - Division/district pest control programs.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Division/district pest control..., DEPARTMENT OF DEFENSE PEST CONTROL PROGRAM FOR CIVIL WORKS PROJECTS Project Operation § 274.6 Division/district pest control programs. (a) Guides. Referenced technical manuals, and Engineer Circulars issued...

  7. 33 CFR 274.6 - Division/district pest control programs.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Division/district pest control..., DEPARTMENT OF DEFENSE PEST CONTROL PROGRAM FOR CIVIL WORKS PROJECTS Project Operation § 274.6 Division/district pest control programs. (a) Guides. Referenced technical manuals, and Engineer Circulars issued...

  8. Publications - GMC 85 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ) well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of Geological & Geophysical (Orion) well: Alaska Division of Geological & Geophysical Surveys Geologic Materials Center Data

  9. Publications - GMC 89 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a ) well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of Geological & Geophysical (Mars) well: Alaska Division of Geological & Geophysical Surveys Geologic Materials Center Data

  10. 28 CFR 3.2 - Assistant Attorney General, Criminal Division.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 28 Judicial Administration 1 2010-07-01 2010-07-01 false Assistant Attorney General, Criminal... Attorney General, Criminal Division. The Assistant Attorney General, Criminal Division, is authorized to exercise the power and authority of and to perform the functions vested in the Attorney General by the Act...

  11. Major Programs | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention supports major scientific collaborations, research networks, investigator-initiated grants, postdoctoral training, and specialized resources across the United States. |

  12. Cyclin D regulation of a sexually dimorphic asymmetric cell division

    PubMed Central

    Tilmann, Christopher; Kimble, Judith

    2006-01-01

    SUMMARY The C. elegans somatic gonadal precursor cell (SGP) divides asymmetrically to establish gonad-specific coordinates in both sexes. In addition, the SGP division is sexually dimorphic and initiates sex-specific programs of gonadogenesis. Wnt/MAPK signaling determines the gonadal axes, and the FKH-6 transcription factor specifies the male mode of SGP division. In this paper, we demonstrate that C. elegans cyclin D controls POP-1/TCF asymmetry in the SGP daughters as well as fkh-6 and rnr expression in the SGPs. Although cyclin D mutants have delayed SGP divisions, the cyclin D defects are not mimicked by other methods of retarding the SGP division. We find that EFL-1/E2F has an antagonistic effect on fkh-6 expression and gonadogenesis, which is relieved by cyclin D activity. We propose that cyclin D and other canonical regulators of the G1/S transition coordinate key regulators of axis formation and sex determination with cell cycle progression to achieve the sexually dimorphic SGP asymmetric division. PMID:16198291

  13. 75 FR 45152 - National Security Division: Agency Information Collection Activities: Proposed Collection...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... DEPARTMENT OF JUSTICE [OMB Number 1124-0004] National Security Division: Agency Information...), National Security Division (NSD), will be submitting the following information collection request to the... write to U.S. Department of Justice, 10th & Constitution Avenue, NW., National Security Division...

  14. Publications - GMC 395 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    investigations of the diatom stratigraphy of Borehole TA8, Portage Alaska: Alaska Division of Geological & Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical DGGS GMC 395 Publication Details Title: Preliminary investigations of the diatom stratigraphy of

  15. Division and Brigade Stationing System: Installation Data Book.

    DTIC Science & Technology

    1988-04-01

    8217Division and Brigade Stationing Study: An Analysis of Environmental and Socioeconomic Effects (ESC, September 1987); Division and Brigade Stationing Study...composed of 0 partly decomposed moss, leaves , and twigs, matted together with many fine rootlets. In permafrost areas, destruction of this mat...maritime effect is seldom interrupted by drier and cooler continental air. Although rainfall averages about 48 inches a year, Y annual variation is large

  16. Materials Safety Data Sheets: the basis for control of toxic chemicals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ketchen, E.E.; Porter, W.E.

    1979-09-01

    The Material Safety Data Sheets contained in this volume are the basis for the Toxic Chemical Control Program developed by the Industrial Hygiene Department, Health Division, ORNL. The three volumes are the update and expansion of ORNL/TM-5721 and ORNL/TM-5722 Material Safety Data Sheets: The Basis for Control of Toxic Chemicals, Volume I and Volume II. As such, they are a valuable adjunct to the data cards issued with specific chemicals. The chemicals are identified by name, stores catalog number where appropriate, and sequence numbers from the NIOSH Registry of Toxic Effects of Chemical Substances, 1977 Edition, if available. The datamore » sheets were developed and compiled to aid in apprising the employees of hazards peculiar to the handling and/or use of specific toxic chemicals. Space limitation necessitate the use of descriptive medical terms and toxicological abbreviations. A glossary and an abbreviation list were developed to define some of those sometimes unfamiliar terms and abbreviations. The page numbers are keyed to the catalog number in the chemical stores at ORNL.« less

  17. Materials Safety Data Sheets: the basis for control of toxic chemicals

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Ketchen, E.E.; Porter, W.E.

    The Material Safety Data Sheets contained in this volume are the basis for the Toxic Chemical Control Program developed by the Industrial Hygiene Department, Health Division, ORNL. The three volumes are the update and expansion of ORNL/TM-5721 and ORNL/TM-5722 Material Safety Data Sheets: The Basis for Control of Toxic Chemicals, Volume I and Volume II. As such, they are a valuable adjunct to the data cards issued with specific chemicals. The chemicals are identified by name, stores catalog number where appropriate, and sequence numbers from the NIOSH Registry of Toxic Effects of Chemical Substances, 1977 Edition, if available. The datamore » sheets were developed and compiled to aid in apprising the employees of hazards peculiar to the handling and/or use of specific toxic chemicals. Space limitation necessitate the use of descriptive medical terms and toxicological abbreviations. A glossary and an abbreviation list were developed to define some of those sometimes unfamiliar terms and abbreviations. The page numbers are keyed to the catalog number in the chemical stores at ORNL.« less

  18. Publications - AR 2011-F | Alaska Division of Geological & Geophysical

    Science.gov Websites

    project descriptions, in DGGS Staff, Alaska Division of Geological & Geophysical Surveys Annual Report Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2011-F main

  19. Publications - AR 2011-E | Alaska Division of Geological & Geophysical

    Science.gov Websites

    , Geologic Communications FY12 project descriptions, in DGGS Staff, Alaska Division of Geological & Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2011-E main

  20. Publications - AR 2010-E | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Communications FY11 project descriptions, in DGGS Staff, Alaska Division of Geological & Geophysical Surveys Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2010-E main

  1. Publications - AR 2010-A | Alaska Division of Geological & Geophysical

    Science.gov Websites

    FY11 project descriptions, in DGGS Staff, Alaska Division of Geological & Geophysical Surveys Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2010-A main

  2. Publications - AR 2010-F | Alaska Division of Geological & Geophysical

    Science.gov Websites

    project descriptions, in DGGS Staff, Alaska Division of Geological & Geophysical Surveys Annual Report Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical Facebook DGGS News Natural Resources Geological & Geophysical Surveys Publications AR 2010-F main

  3. 5 CFR 831.641 - Division of a survivor annuity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Division of a survivor annuity. 831.641... REGULATIONS (CONTINUED) RETIREMENT Survivor Annuities Eligibility § 831.641 Division of a survivor annuity. (a... annuities (not including any benefits based on an election of an insurable interest annuity) payable based...

  4. 5 CFR 842.613 - Division of a survivor annuity.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 5 Administrative Personnel 2 2010-01-01 2010-01-01 false Division of a survivor annuity. 842.613... REGULATIONS (CONTINUED) FEDERAL EMPLOYEES RETIREMENT SYSTEM-BASIC ANNUITY Survivor Elections § 842.613 Division of a survivor annuity. (a) The maximum combined total of all current and former spouse annuities...

  5. Staff - Susan S. Seitz | Alaska Division of Geological & Geophysical

    Science.gov Websites

    , 2017, Geologic Photos of Alaska: Alaska Division of Geological & Geophysical Surveys Digital Data ., Seitz, S.S., and Mulliken, K.M., 2016, Digital compilation of geochemical data for historical samples (presentation): Digital Mapping Techniques Workshop, Champaign, Illinois, May 20-23, 2012: Alaska Division of

  6. Order Division Automated System.

    ERIC Educational Resources Information Center

    Kniemeyer, Justin M.; And Others

    This publication was prepared by the Order Division Automation Project staff to fulfill the Library of Congress' requirement to document all automation efforts. The report was originally intended for internal use only and not for distribution outside the Library. It is now felt that the library community at-large may have an interest in the…

  7. [Starting with camphor--the progress of Nippon Fine Chemical].

    PubMed

    Kimura, Osamu

    2010-01-01

    In 1918, Nippon Fine Chemical Co., Ltd. (NFC) was founded under the name, Nippon Camphor Co., Ltd. for the purpose of unifying the camphor business throughout Japan. The company manufactured purified camphor as a government-monopolized good. Camphor was used as a plasticizer for nitrocellulose, as a moth repellent, as an antimicrobial substance, as a rust inhibitor, and as an active ingredient in medicine. It was also a very important good exported in order to obtain foreign currency. Later on, after World War II and the abolition of the camphor monopoly, the company started manufacturing products related to oils and fats, including higher fatty acids, and expanded its business by developing a new field of chemical industry. In 1971 the company changed its name to Nippon Fine Chemical Co., Ltd., and made a new start as a diversified fine chemicals company. Recently, the fine chemicals division of NFC has concentrated on rather complex molecules, such as active pharmaceutical ingredients, and other chemicals. Since 2000, NFC have started to supply "Presome", precursors of liposome DDS drugs. NFC is strengthening marketing strategies in foreign countries with unique technologies and products.

  8. Long-range ordered vorticity patterns in living tissue induced by cell division

    NASA Astrophysics Data System (ADS)

    Rossen, Ninna S.; Tarp, Jens M.; Mathiesen, Joachim; Jensen, Mogens H.; Oddershede, Lene B.

    2014-12-01

    In healthy blood vessels with a laminar blood flow, the endothelial cell division rate is low, only sufficient to replace apoptotic cells. The division rate significantly increases during embryonic development and under halted or turbulent flow. Cells in barrier tissue are connected and their motility is highly correlated. Here we investigate the long-range dynamics induced by cell division in an endothelial monolayer under non-flow conditions, mimicking the conditions during vessel formation or around blood clots. Cell divisions induce long-range, well-ordered vortex patterns extending several cell diameters away from the division site, in spite of the system’s low Reynolds number. Our experimental results are reproduced by a hydrodynamic continuum model simulating division as a local pressure increase corresponding to a local tension decrease. Such long-range physical communication may be crucial for embryonic development and for healing tissue, for instance around blood clots.

  9. Biology Division. Progress report, August 1, 1982-September 30, 1983

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1984-01-01

    The Biology Division is the component of the Oak Ridge National Laboratory that investigates the potential adverse health effects of energy-related substances. The body of this report provides summaries of the aims, scope and progress of the research of groups of investigators in the Division during the period of August 1, 1982, through September 30, 1983. At the end of each summary is a list of publications covering the same period (published or accepted for publication). For convenience, the summaries are assembled under Sections in accordance with the current organizational structure of the Biology Division; each Section begins with anmore » overview. It will be apparent, however, that currents run throughout the Division and that the various programs support and interact with each other.« less

  10. Phytoplankton division rates in light-limited environments: two adaptations

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Rivkin, R.B.; Voytek, M.A.; Seliger, H.H.

    1982-02-26

    Red tide-forming dinoflagellates maximize cell numbers during periods of low light intensities in two ways. For short-term exposures to suboptimal light intensities such as might occur during recirculation in frontal convergences, cell division rates can be maintained at the expense of stored carbon for up to two generation times. During longer periods, corresponding to subsurface transport below a pycnocline, cell division rates eventually decrease as a portion of the fixed carbon is diverted to replenishing stored carbon. As a result, maximum rates of cell division can be resumed rapidly upon advection into surface waters where light intensities are optimal formore » growth.« less

  11. Publications - SR 46 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    , R.C., Wood, J.E., and Clough, A.H. Publication Date: 1991 Publisher: Alaska Division of Geological , R.C., Wood, J.E., and Clough, A.H., 1991, Alaska's mineral industry 1991: Alaska Division of ; Beryllium; Bismuth; Ceramics; Chromium; Coal; Cobalt; Construction Materials; Copper; Cultural Resources

  12. Publications - GMC 81 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a Company Long Island #1 well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of for the Sohio Alaska Petroleum Company Long Island #1 well: Alaska Division of Geological &

  13. Publications - GMC 77 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a California Leffingwell #1 well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of for the Union Oil Company of California Leffingwell #1 well: Alaska Division of Geological &

  14. Publications - GMC 90 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a -1 (Hammerhead) well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of Geological for the Union Oil Company OCS-Y-0849-1 (Hammerhead) well: Alaska Division of Geological &

  15. An Exploration of Challenges Facing Division III Athletic Directors

    ERIC Educational Resources Information Center

    Engbers, Jeffrey L.

    2011-01-01

    The purpose of this study was to establish a basic understanding of the challenges associated with directing athletic programs at NCAA Division III Institutions. Specifically, this study identified the frequency, intensity, and time allocated to common challenges facing the position of the NCAA Division III AD. The challenges were examined using…

  16. Women of the Solar Physics Division

    NASA Astrophysics Data System (ADS)

    Dupree, Andrea K.

    2007-05-01

    In 1970, when the Solar Physics Division was established, the invitation to become a founding member of the Division was extended by the Organizing Committee to a group of 61 solar scientists of which 4 were women (6.6%). At the first SPD meeting in Huntsville AL (1970), 11% of the papers were given by women. Near that time (1973), women accounted for 8% of all AAS members. The representation of women in the SPD has more than doubled in percentage since the first years. Currently, women comprise about 15.5% of SPD members which, however, is less than the percentage in the AAS general membership (18%) in March 2007. In the 37 years that the SPD has existed, women have frequently held the office of Treasurer and Secretary of the Division and made notable contributions. Elske V.P. Smith was elected the first Treasurer of the SPD and that began a long tradition. Women appear to be considered exceptionally trustworthy since they have been reelected and occupied the position of Treasurer for 75% of the available terms. The Office of SPD Secretary has seen a woman for 13% of the terms. Yet women are practically absent among those in the top leadership positions and in the lists of prize winners of the SPD. Among the 21 SPD Chairs, only 1 woman, Judith T. Karpen, has held that office. The Hale Prize has been awarded 19 times in almost 3 decades, and all of the awardees have been men. Several aspects of the participation of women and their contributions to the Solar Physics Division of the AAS will be reviewed, and compared to that of the AAS and astronomy in general.

  17. The Office of the Materials Division

    NASA Technical Reports Server (NTRS)

    Ramsey, amanda J.

    2004-01-01

    I was assigned to the Materials Division, which consists of the following branches; the Advanced Metallics Branch/5120-RMM, Ceramics Branch/5130-RMC, Polymers Branch/5150-RMP, and the Durability and Protective Coatings Branch/5160-RMD. Mrs. Pamela Spinosi is my assigned mentor. She was assisted by Ms.Raysa Rodriguez/5100-RM and Mrs.Denise Prestien/5100-RM, who are both employed by InDyne, Inc. My primary assignment this past summer was working directly with Ms. Rodriguez, assisting her with setting up the Integrated Financial Management Program (IFMP) 5130-RMC/Branch procedures and logs. These duties consisted of creating various spreadsheets for each individual branch member, which were updated daily. It was not hard to familiarize myself with these duties since this is my second summer working with Ms Rodriguez at NASA Glenn Research Center. RMC ordering laboratory, supplies and equipment for the Basic Materials Laboratory (Building 106) using the IF'MP/Purchase Card (P-card), a NASA-wide software program. I entered into the IFMP/Travel and Requisitions System, new Travel Authorizations for the 5130-RMC Civil Servant Branch Members. I also entered and completed Travel Vouchers for the 5130-RMC Ceramics Branch. I assisted in the Division Office creating new Emergency Contact list for the Materials Division. I worked with Dr. Hugh Gray, the Division Chief, and Dr. Ajay Misra, the 5130-RMC Branch Chief, on priority action items, with a close deadline, for a large NASA Proposal. Another project was working closely with Ms. Rodriguez in organizing and preparing for Dr. Ajay K. Misra's SESCDP (two year detail). This consisted of organizing files, file folders, personal information, and recording all data material onto CD's and printing all presentations for display in binders. I attended numerous Branch meetings, and observed many changes in the Branch Management organization.

  18. Evolution of division of labor: emergence of different activities among group members.

    PubMed

    Nakahashi, Wataru; Feldman, Marcus W

    2014-05-07

    The division of labor is an important component of the organization of human society. However, why this division evolved in hominids requires further investigation. Archeological evidence suggests that it appeared after the emergence of Homo sapiens and contributed to the great success of our species. We develop a mathematical model to investigate under what conditions division of labor should evolve. We assume two types of resources the acquisition of which demands different skills, and study the evolution of the strategy that an individual should use to divide its lifetime into learning and using each skill. We show that division of labor likely evolves when group size is large, skill learning is important for acquiring resources, and there is food sharing within a group. We also investigate division of labor by gender under the assumption that the genders have different efficiencies in acquiring each resource. We show that division of labor by gender likely evolves when skill learning is important and the difference in efficiencies between genders in acquiring resources is large. We discuss how the results of our analysis might apply to the evolution of division of labor in hominids. Copyright © 2014 Elsevier Ltd. All rights reserved.

  19. Automated cell tracking identifies mechanically oriented cell divisions during Drosophila axis elongation.

    PubMed

    Wang, Michael F Z; Hunter, Miranda V; Wang, Gang; McFaul, Christopher; Yip, Christopher M; Fernandez-Gonzalez, Rodrigo

    2017-04-01

    Embryos extend their anterior-posterior (AP) axis in a conserved process known as axis elongation. Drosophila axis elongation occurs in an epithelial monolayer, the germband, and is driven by cell intercalation, cell shape changes, and oriented cell divisions at the posterior germband. Anterior germband cells also divide during axis elongation. We developed image analysis and pattern-recognition methods to track dividing cells from confocal microscopy movies in a generally applicable approach. Mesectoderm cells, forming the ventral midline, divided parallel to the AP axis, while lateral cells displayed a uniform distribution of division orientations. Mesectoderm cells did not intercalate and sustained increased AP strain before cell division. After division, mesectoderm cell density increased along the AP axis, thus relieving strain. We used laser ablation to isolate mesectoderm cells from the influence of other tissues. Uncoupling the mesectoderm from intercalating cells did not affect cell division orientation. Conversely, separating the mesectoderm from the anterior and posterior poles of the embryo resulted in uniformly oriented divisions. Our data suggest that mesectoderm cells align their division angle to reduce strain caused by mechanical forces along the AP axis of the embryo. © 2017. Published by The Company of Biologists Ltd.

  20. Annual Report, Reservoir Control Center, Southwestern Division (1989)

    DTIC Science & Technology

    1990-01-01

    Division in the water quality field . This provides for water quality objectives being included as an effective part of our total water management...WES) selected Canyon Lake as a research field site for developing techniques to evaluate the impacts associated with installation of hydropower at Corps...term continuous goals of this Division, and consequently the Water Management Branch, in the water quality field . (1) To obtain sufficient water

  1. HEP Division Argonne National Laboratory

    Science.gov Websites

    Argonne National Laboratory Environmental Safety & Health DOE Logo Home Division ES&H ... Search Argonne Home >High Energy Physics> Environmental Safety & Health Environmental Safety & Health New Employee Training */ ?> Office Safety: Checklist (Submitted Checklists) Submitted

  2. Publications - GMC 79 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a Island #A-3) well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of Geological & Western BF-57 #1 (Seal Island #A-3) well: Alaska Division of Geological & Geophysical Surveys Geologic

  3. Publications - GMC 76 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a -1 (Antares #1) well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of Geological for the Exxon corporation OCS-Y-0280-1 (Antares #1) well: Alaska Division of Geological &

  4. Publications - GMC 80 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a California Tungak Creek #1 well Authors: Unknown Publication Date: 1988 Publisher: Alaska Division of for the Union Oil Company of California Tungak Creek #1 well: Alaska Division of Geological &

  5. Publications - RDF 2015-8 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    from the Tonsina area, Valdez Quadrangle, Alaska: Alaska Division of Geological & Geophysical Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  6. Unmanned Aerial Vehicle Non Line of Sight Chemical Detection Final Report

    DTIC Science & Technology

    2016-12-01

    aircraft system that is used to perform point detection of chemical warfare agents and collection of vapor, liquid, and solid samples. A modular payload...Standoff Quadcopter Unmanned aircraft system Modular payload 16. SECURITY CLASSIFICATION OF: 17. LIMITATION OF ABSTRACT 18. NUMBER OF...Manufacturing Division, modular payloads are being developed to perform point detection and CBRNE sampling. The available UAS is a quadcopter capable of

  7. Images multiplexing by code division technique

    NASA Astrophysics Data System (ADS)

    Kuo, Chung J.; Rigas, Harriett

    Spread Spectrum System (SSS) or Code Division Multiple Access System (CDMAS) has been studied for a long time, but most of the attention was focused on the transmission problems. In this paper, we study the results when the code division technique is applied to the image at the source stage. The idea is to convolve the N different images with the corresponding m-sequence to obtain the encrypted image. The superimposed image (summation of the encrypted images) is then stored or transmitted. The benefit of this is that no one knows what is stored or transmitted unless the m-sequence is known. The recovery of the original image is recovered by correlating the superimposed image with corresponding m-sequence. Two cases are studied in this paper. First, the two-dimensional image is treated as a long one-dimensional vector and the m-sequence is employed to obtain the results. Secondly, the two-dimensional quasi m-array is proposed and used for the code division multiplexing. It is shown that quasi m-array is faster when the image size is 256 x 256. The important features of the proposed technique are not only the image security but also the data compactness. The compression ratio depends on how many images are superimposed.

  8. Images Multiplexing By Code Division Technique

    NASA Astrophysics Data System (ADS)

    Kuo, Chung Jung; Rigas, Harriett B.

    1990-01-01

    Spread Spectrum System (SSS) or Code Division Multiple Access System (CDMAS) has been studied for a long time, but most of the attention was focused on the transmission problems. In this paper, we study the results when the code division technique is applied to the image at the source stage. The idea is to convolve the N different images with the corresponding m-sequence to obtain the encrypted image. The superimposed image (summation of the encrypted images) is then stored or transmitted. The benefit of this is that no one knows what is stored or transmitted unless the m-sequence is known. The recovery of the original image is recovered by correlating the superimposed image with corresponding m-sequence. Two cases are studied in this paper. First, the 2-D image is treated as a long 1-D vector and the m-sequence is employed to obtained the results. Secondly, the 2-D quasi m-array is proposed and used for the code division multiplexing. It is showed that quasi m-array is faster when the image size is 256x256. The important features of the proposed technique are not only the image security but also the data compactness. The compression ratio depends on how many images are superimposed.

  9. Characterization of dependencies between growth and division in budding yeast

    PubMed Central

    Iversen, Edwin S.; Hartemink, Alexander J.

    2017-01-01

    Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding yeast Saccharomyces cerevisiae, this coordination or ‘size control’ appears as an inverse correlation between cell size and the rate of cell-cycle progression, routinely observed in G1 prior to cell division commitment. Beyond this point, cells are presumed to complete S/G2/M at similar rates and in a size-independent manner. As such, studies of dependence between growth and division have focused on G1. Moreover, in unicellular organisms, coordination between growth and division has commonly been analysed within the cycle of a single cell without accounting for correlations in growth and division characteristics between cycles of related cells. In a comprehensive analysis of three published time-lapse microscopy datasets, we analyse both intra- and inter-cycle dependencies between growth and division, revisiting assumptions about the coordination between these two processes. Interestingly, we find evidence (i) that S/G2/M durations are systematically longer in daughters than in mothers, (ii) of dependencies between S/G2/M and size at budding that echo the classical G1 dependencies, and (iii) in contrast with recent bacterial studies, of negative dependencies between size at birth and size accumulated during the cell cycle. In addition, we develop a novel hierarchical model to uncover inter-cycle dependencies, and we find evidence for such dependencies in cells growing in sugar-poor environments. Our analysis highlights the need for experimentalists and modellers to account for new sources of cell-to-cell variation in growth and division, and our model provides a formal statistical framework for the continued study of dependencies between biological processes. PMID:28228543

  10. Characterization of dependencies between growth and division in budding yeast.

    PubMed

    Mayhew, Michael B; Iversen, Edwin S; Hartemink, Alexander J

    2017-02-01

    Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding yeast Saccharomyces cerevisiae , this coordination or 'size control' appears as an inverse correlation between cell size and the rate of cell-cycle progression, routinely observed in G 1 prior to cell division commitment. Beyond this point, cells are presumed to complete S/G 2 /M at similar rates and in a size-independent manner. As such, studies of dependence between growth and division have focused on G 1 Moreover, in unicellular organisms, coordination between growth and division has commonly been analysed within the cycle of a single cell without accounting for correlations in growth and division characteristics between cycles of related cells. In a comprehensive analysis of three published time-lapse microscopy datasets, we analyse both intra- and inter-cycle dependencies between growth and division, revisiting assumptions about the coordination between these two processes. Interestingly, we find evidence (i) that S/G 2 /M durations are systematically longer in daughters than in mothers, (ii) of dependencies between S/G 2 /M and size at budding that echo the classical G 1 dependencies, and (iii) in contrast with recent bacterial studies, of negative dependencies between size at birth and size accumulated during the cell cycle. In addition, we develop a novel hierarchical model to uncover inter-cycle dependencies, and we find evidence for such dependencies in cells growing in sugar-poor environments. Our analysis highlights the need for experimentalists and modellers to account for new sources of cell-to-cell variation in growth and division, and our model provides a formal statistical framework for the continued study of dependencies between biological processes. © 2017 The Author(s).

  11. Characterization of dependencies between growth and division in budding yeast

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Mayhew, Michael B.; Iversen, Edwin S.; Hartemink, Alexander J.

    Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding yeast Saccharomyces cerevisiae, this coordination or ‘size control’ appears as an inverse correlation between cell size and the rate of cell-cycle progression, routinely observed in G1 prior to cell division commitment. Beyond this point, cells are presumed to complete S/G 2/M at similar rates and in a size-independent manner. As such, studies of dependence between growth and division have focused on G1. Moreover, in unicellular organisms, coordination betweenmore » growth and division has commonly been analyzed within the cycle of a single cell without accounting for correlations in growth and division characteristics between cycles of related cells. In a comprehensive analysis of three published time-lapse microscopy datasets, we analyze both intra- and inter-cycle dependencies between growth and division, revisiting assumptions about the coordination between these two processes. Interestingly, we find evidence (1) that S/G 2/M durations are systematically longer in daughters than in mothers, (2) of dependencies between S/G2/M and size at budding that echo the classical G1 dependencies, and, (3) in contrast with recent bacterial studies, of negative dependencies between size at birth and size accumulated during the cell cycle. In addition, we develop a novel hierarchical model to uncover inter-cycle dependencies, and we find evidence for such dependencies in cells growing in sugar-poor environments. Our analysis highlights the need for experimentalists and modelers to account for new sources of cell-to-cell variation in growth and division, and our model provides a formal statistical framework for the continued study of dependencies between biological processes.« less

  12. Characterization of dependencies between growth and division in budding yeast

    DOE PAGES

    Mayhew, Michael B.; Iversen, Edwin S.; Hartemink, Alexander J.

    2017-02-01

    Cell growth and division are processes vital to the proliferation and development of life. Coordination between these two processes has been recognized for decades in a variety of organisms. In the budding yeast Saccharomyces cerevisiae, this coordination or ‘size control’ appears as an inverse correlation between cell size and the rate of cell-cycle progression, routinely observed in G1 prior to cell division commitment. Beyond this point, cells are presumed to complete S/G 2/M at similar rates and in a size-independent manner. As such, studies of dependence between growth and division have focused on G1. Moreover, in unicellular organisms, coordination betweenmore » growth and division has commonly been analyzed within the cycle of a single cell without accounting for correlations in growth and division characteristics between cycles of related cells. In a comprehensive analysis of three published time-lapse microscopy datasets, we analyze both intra- and inter-cycle dependencies between growth and division, revisiting assumptions about the coordination between these two processes. Interestingly, we find evidence (1) that S/G 2/M durations are systematically longer in daughters than in mothers, (2) of dependencies between S/G2/M and size at budding that echo the classical G1 dependencies, and, (3) in contrast with recent bacterial studies, of negative dependencies between size at birth and size accumulated during the cell cycle. In addition, we develop a novel hierarchical model to uncover inter-cycle dependencies, and we find evidence for such dependencies in cells growing in sugar-poor environments. Our analysis highlights the need for experimentalists and modelers to account for new sources of cell-to-cell variation in growth and division, and our model provides a formal statistical framework for the continued study of dependencies between biological processes.« less

  13. Review of travel data issues in VDOT's Transportation Planning Division.

    DOT National Transportation Integrated Search

    1991-01-01

    The Transportation Planning Division (TPD) of the Virginia Department of Transportation uses an extensive amount of travel data in both its routine planning activities and its provision of data forecasts to other divisions. Travel data consist of suc...

  14. 75 FR 45154 - National Security Division; Agency Information Collection Activities:

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-02

    ... DEPARTMENT OF JUSTICE [OMB Number 1124-0003] National Security Division; Agency Information Collection Activities: Proposed Collection; Comments Requested ACTION: 60-Day Notice of Information...), National Security Division (NSD), will be submitting the following information collection request to the...

  15. Influence of growing system on nitrate accumulation in two varieties of lettuce and red radicchio of Treviso.

    PubMed

    Lucarini, Massimo; D'Evoli, Laura; Tufi, Sara; Gabrielli, Paolo; Paoletti, Sara; Di Ferdinando, Sandra; Lombardi-Boccia, Ginevra

    2012-11-01

    Green leafy vegetables contribute greatly to the total intake of nitrates from the daily diet. This study evaluates the influence of different cultivation systems on nitrate accumulation in leafy vegetables. Two varieties of lettuce (Lactuca sativa L.) (Lattuga Romana, Foglia di Quercia) and two varieties of red radicchio of Treviso (Cychorium intibus L.) (Early, Late) were selected. Lettuce varieties were both organically and biodynamically grown; red radicchio varieties were conventionally grown both in the field and in spring water. Both lettuce varieties biodynamically grown accumulated 1.3-2 times less nitrate than the respective organically grown plants. The two lettuce varieties showed differences in nitrate accumulating capacity: Foglia di Quercia was almost three times richer in nitrate than Lattuga Romana. The traditional growing systems applied to the red radicchio of Treviso varieties strongly influenced nitrate accumulation in leaves, the Early variety having up to 15 times higher nitrate than the Late variety. Our findings on nitrate levels in both lettuce and red radicchio of Treviso varieties suggest that both genetic factors and cultivation systems strongly affect the nitrate accumulation capacity. This study also highlights how the cultivation strategy can reduce nitrate levels in leafy vegetables, suggesting the possibility of modulating the N supply along the harvesting time. Copyright © 2011 Society of Chemical Industry.

  16. The Effect of Microplastic on the Uptake of Chemicals by the Lugworm Arenicola marina (L.) under Environmentally Relevant Exposure Conditions.

    PubMed

    Besseling, Ellen; Foekema, Edwin M; van den Heuvel-Greve, Martine J; Koelmans, Albert A

    2017-08-01

    It has been hypothesized that ingestion of microplastic increases exposure of aquatic organisms to hydrophobic contaminants. To date, most laboratory studies investigated chemical transfer from ingested microplastic without taking other exposure pathways into account. Therefore, we studied the effect of polyethylene (PE) microplastic in sediment on PCB uptake by Arenicola marina as a model species, quantifying uptake fluxes from all natural exposure pathways. PCB concentrations in sediment, biota lipids (C lip ) and porewater measured with passive samplers were used to derive lipid-normalized bioaccumulation metrics C lip , Biota sediment accumulation factor (BSAF), Bioaccumulation factor (BAF) and the Biota plastic accumulation factor (BPAF). Small effects of PE addition were detected suggesting slightly increased or decreased bioaccumulation. However, the differences decreased in magnitude dependent on the metric used to assess bioaccumulation, in the order: C lip > BSAF > BPAF > BAF, and were nonsignificant for BAF. The fact that BAF, that is, normalization of C lip on porewater concentration, largely removed all effects of PE, shows that PE did not act as a measurable vector of PCBs. Biodynamic model analysis confirmed that PE ingestion contributed marginally to bioaccumulation. This work confirmed model-based predictions on the limited relevance of microplastic for bioaccumulation under environmentally realistic conditions, and illustrated the importance of assessing exposure through all media in microplastic bioaccumulation studies.

  17. Oriented cell division shapes carnivorous pitcher leaves of Sarracenia purpurea.

    PubMed

    Fukushima, Kenji; Fujita, Hironori; Yamaguchi, Takahiro; Kawaguchi, Masayoshi; Tsukaya, Hirokazu; Hasebe, Mitsuyasu

    2015-03-16

    Complex morphology is an evolutionary outcome of phenotypic diversification. In some carnivorous plants, the ancestral planar leaf has been modified to form a pitcher shape. However, how leaf development was altered during evolution remains unknown. Here we show that the pitcher leaves of Sarracenia purpurea develop through cell division patterns of adaxial tissues that are distinct from those in bifacial and peltate leaves, subsequent to standard expression of adaxial and abaxial marker genes. Differences in the orientation of cell divisions in the adaxial domain cause bifacial growth in the distal region and adaxial ridge protrusion in the middle region. These different growth patterns establish pitcher morphology. A computer simulation suggests that the cell division plane is critical for the pitcher morphogenesis. Our results imply that tissue-specific changes in the orientation of cell division underlie the development of a morphologically complex leaf.

  18. Alignment of cell division axes in directed epithelial cell migration

    NASA Astrophysics Data System (ADS)

    Marel, Anna-Kristina; Podewitz, Nils; Zorn, Matthias; Oskar Rädler, Joachim; Elgeti, Jens

    2014-11-01

    Cell division is an essential dynamic event in tissue remodeling during wound healing, cancer and embryogenesis. In collective migration, tensile stresses affect cell shape and polarity, hence, the orientation of the cell division axis is expected to depend on cellular flow patterns. Here, we study the degree of orientation of cell division axes in migrating and resting epithelial cell sheets. We use microstructured channels to create a defined scenario of directed cell invasion and compare this situation to resting but proliferating cell monolayers. In experiments, we find a strong alignment of the axis due to directed flow while resting sheets show very weak global order, but local flow gradients still correlate strongly with the cell division axis. We compare experimental results with a previously published mesoscopic particle based simulation model. Most of the observed effects are reproduced by the simulations.

  19. Publications - GMC 97 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a Inlet Unit A-2 well Authors: Core Laboratories Publication Date: 1988 Publisher: Alaska Division of of the Phillips Petroleum Company North Cook Inlet Unit A-2 well: Alaska Division of Geological &

  20. Publications - RDF 2015-16 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    rocks collected in 2015 in the Wrangellia mineral assessment area, Alaska: Alaska Division of Geological Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  1. Publications - RDF 2015-9 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    samples from the Zane Hills, Hughes and Shungnak quadrangles, Alaska: Alaska Division of Geological & Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  2. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    MSD Support Human Resources Facilities & Space Planning Procurement and Property Proposals & ; Finance Templates Travel One-Stop Acknowledging MSD Support Human Resources Facilities & Space Operations For information regarding Human Resources, procedures for acknowledging MSD support, division

  3. Synthetic Division and Matrix Factorization

    ERIC Educational Resources Information Center

    Barabe, Samuel; Dubeau, Franc

    2007-01-01

    Synthetic division is viewed as a change of basis for polynomials written under the Newton form. Then, the transition matrices obtained from a sequence of changes of basis are used to factorize the inverse of a bidiagonal matrix or a block bidiagonal matrix.

  4. PDV2 has a dosage effect on chloroplast division in Arabidopsis.

    PubMed

    Chang, Ning; Sun, Qingqing; Li, Yiqiong; Mu, Yajuan; Hu, Jinglei; Feng, Yue; Liu, Xiaomin; Gao, Hongbo

    2017-03-01

    PDV2 has a dosage effect on chloroplast division in Arabidopsis thaliana , but this effect may vary in different plants. Chloroplasts have to be divided as plants grow to maintain an optimized number in the cell. Chloroplasts are divided by protein complexes across the double membranes from the stroma side to the cytosolic side. PDV2 is a chloroplast division protein on the chloroplast outer membrane. It recruits the dynamin-related GTPase ARC5 to the division site. The C-terminus of PDV2 and the C-terminus of ARC6 interact in the intermembrane space, which is important for the localization of PDV2. Previously, it was shown that overexpression of PDV2 can increase the division of chloroplasts in Arabidopsis and moss, so the authors concluded that PDV2 determines the rate of chloroplast division in land plants. PDV2 was also shown to inhibit the GTPase activity of ARC5 by in vitro experiment. These results look to be contradictory. Here, we identified a null allele of PDV2 in Arabidopsis and studied plants with different levels of PDV2. Our results suggested that the chloroplast division phenotype in Arabidopsis is sensitive to the level of PDV2, while this is not the case for ARC6. The level of PDV2 protein is reduced sharply in fast-growing leaves, while the level of ARC6 is not. The levels of PDV2 and ARC6 in several other plant species at different developmental stages were also investigated. The results indicated that their expression pattern varies in different species. Thus, PDV2 is an important positive factor of chloroplast division with an apparent dosage effect in Arabidopsis, but this effect for different chloroplast division proteins in different plants may vary.

  5. Z ring as executor of bacterial cell division.

    PubMed

    Dajkovic, Alex; Lutkenhaus, Joe

    2006-01-01

    It has become apparent that bacteria possess ancestors of the major eukaryotic cytoskeletal proteins. FtsZ, the ancestral homologue of tubulin, assembles into a cytoskeletal structure associated with cell division, designated the Z ring. Formation of the Z ring represents a major point of both spatial and temporal regulation of cell division. Here we discuss findings concerning the structure and the formation of the ring as well as its spatial and temporal regulation.

  6. Fielding a Division Staff in the Modern Day

    DTIC Science & Technology

    2016-06-10

    FIELDING A DIVISION STAFF IN THE MODERN DAY A thesis presented to the Faculty of the U.S. Army Command and General Staff ...TITLE AND SUBTITLE Fielding a Division Staff in the Modern Day 5a. CONTRACT NUMBER 5b. GRANT NUMBER 5c. PROGRAM ELEMENT NUMBER 6...ADDRESS(ES) U.S. Army Command and General Staff College ATTN: ATZL-SWD-GD Fort Leavenworth, KS 66027-2301 8. PERFORMING ORG REPORT NUMBER 9

  7. A Balancing Act: Division III Student-Athletes Time Demands and Life Roles

    ERIC Educational Resources Information Center

    Hoover, Daniel R., Jr.

    2012-01-01

    A majority of the research on student-athletes occurs at the Division I level, acid less is known about Division III student-athletes. The scant research addressing the experiences of Division III students-athletes focused on academics, campus involvement, development, and athletic identity (Griffith & Johnson, 2002; Heuser & Gray, 2009;…

  8. CHEMISTRY FOR THE SAFETY MAN. SAFETY IN INDUSTRY--ENVIRONMENTAL AND CHEMICAL HAZARDS SERVICES.

    ERIC Educational Resources Information Center

    CESTRONE, PATRICK F.

    THIS BULLETIN, ONE OF A SERIES ON SAFETY IN INDUSTRY, IS INTENDED TO PROVIDE THE BACKGROUND WHICH WILL ENABLE THE SAFETY MAN TO UNDERSTAND SOME OF THE PRINCIPLES APPLIED IN CONTROLLING CHEMICAL HAZARDS. IT WAS PREPARED IN THE OFFICE OF OCCUPATIONAL SAFETY, DIVISION OF PROGRAMING AND RESEARCH, BUREAU OF LABOR STANDARDS. TOPICS INCLUDE (1) WHAT IS…

  9. Health, Safety, and Environment Division

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Wade, C

    1992-01-01

    The primary responsibility of the Health, Safety, and Environmental (HSE) Division at the Los Alamos National Laboratory is to provide comprehensive occupational health and safety programs, waste processing, and environmental protection. These activities are designed to protect the worker, the public, and the environment. Meeting these responsibilities requires expertise in many disciplines, including radiation protection, industrial hygiene, safety, occupational medicine, environmental science and engineering, analytical chemistry, epidemiology, and waste management. New and challenging health, safety, and environmental problems occasionally arise from the diverse research and development work of the Laboratory, and research programs in HSE Division often stem from thesemore » applied needs. These programs continue but are also extended, as needed, to study specific problems for the Department of Energy. The results of these programs help develop better practices in occupational health and safety, radiation protection, and environmental science.« less

  10. Positive effects, side effects, and adverse events of clinical holistic medicine. A review of Gerda Boyesen's nonpharmaceutical mind-body medicine (biodynamic body-psychotherapy) at two centers in the United Kingdom and Germany.

    PubMed

    Allmer, Charlotte; Ventegodt, Søren; Kandel, Isack; Merrick, Joav

    2009-01-01

    To review adverse events of intensive, clinical holistic medicine (CHM) as it is practiced in holistic body-psychotherapy in England and Germany. Gerda Boyesen's "biodynamic body-psychotherapy" (BBP) is an intensive type of holistic mind-body medicine used by Boyesen at two centers. About 13,500 patients were treated during 1985-2005 period and studied for side effects and adverse events. The first author worked closely with Boyesen 1995-2005 with full insight in all aspects of the therapy and provided the data on side-effects. Therapy helped chronic patients with physical, psychological, sexual, psychiatric and existential problems to improve health, ability, and quality of life (NNT (number needed to treat) = 1-3). Effective in the treatment of mentally ill patients (schizophrenia, anxiety, poor mental health, low general ability). For retraumatization, brief reactive psychosis, depression, depersonalization and derealization, implanted memories, side effects from manipulations of the body, suicide/suicide attempts, hospitalization for physical and mental health problem during or 90 days after treatment, NNH (number needed to harm) > 13,500. Intensive, holistic non-drug medicine is helpful for physical, sexual, psychological, psychiatric and existential problems and is completely safe for the patient. The therapeutic value TV = NNH/NNT > 5,000. Altogether about 18,000 patients treated with different subtypes of CHM in four different countries have now been evaluated for effects, side effects and adverse events, with similar results.

  11. 77 FR 57007 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-17

    ... Airworthiness Directives; Pratt & Whitney Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA... turbofan engines. That AD currently requires initial and repetitive fluorescent penetrant inspections (FPI... applies to the following Pratt & Whitney Division (Pratt & Whitney) turbofan engines: (1) PW4000-94...

  12. Publications - NL 2002-1 | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical 2002 Publisher: Alaska Division of Geological & Geophysical Surveys Ordering Info: Download below Reference DGGS Staff, and Werdon, M.B., 2002, Alaska GeoSurvey News - Geologic Investigations in the Salcha

  13. Pancreatic Cancer Chemoprevention Translational Workshop | Division of Cancer Prevention

    Cancer.gov

    Thursday, September 10th (6:00 to 9:30 PM) Welcome Barnett Kramer, MD, MPH (6:00 to 6:10 PM) Director of the Division of Cancer Prevention, NCI Introduction – Goals of the Workshop: ABCs of Cancer Prevention (Agents, Biomarkers, Cohorts) Mark Miller, PhD (6:10 to 6:25 PM) Program Director Division of Cancer Prevention, NCI |

  14. Publications - SR 47 | Alaska Division of Geological & Geophysical Surveys

    Science.gov Websites

    and Facilities Staff Seismic and Well Data Data Reports Contact Us Frequently Asked Questions Ask a , T.K., Clough, A.H., Hansen, E.W., and Nelson, M.G. Publication Date: 1993 Publisher: Alaska Division ., Clough, A.H., Hansen, E.W., and Nelson, M.G., 1993, Alaska's mineral industry 1992: Alaska Division of

  15. Asymmetric cell division of stem cells in the lung and other systems

    PubMed Central

    Berika, Mohamed; Elgayyar, Marwa E.; El-Hashash, Ahmed H. K.

    2014-01-01

    New insights have been added to identification, behavior and cellular properties of embryonic and tissue-specific stem cells over the last few years. The modes of stem cell division, asymmetric vs. symmetric, are tightly regulated during development and regeneration. The proper choice of a stem cell to divide asymmetrically or symmetrically has great consequences for development and disease because inappropriate asymmetric division disrupts organ morphogenesis, whereas uncontrolled symmetric division induces tumorigenesis. Therefore, understanding the behavior of lung stem cells could identify innovative solutions for restoring normal morphogenesis and/or regeneration of different organs. In this concise review, we describe recent studies in our laboratory about the mode of division of lung epithelial stem cells. We also compare asymmetric cell division (ACD) in the lung stem cells with other tissues in different organisms. PMID:25364740

  16. Metals and Ceramics Division progress report for period ending December 31, 1993

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Craig, D.F.; Bradley, R.A.; Weir, J.R. Jr.

    1994-07-01

    This report provides an overview of activities and accomplishsments of the division from October 1992 through December 1993; the division is organized to provide technical support, mainly in the area of high-temperature materials, for technologies being developed by DOE. Activities span the range from basic research to industrial interactions (cooperative research and technology transfer). Sections 1-5 describe the different functional groups (engineering materials, high-temperature materials, materials science, ceramics, nuclear fuel materials). Sect. 6 provides an alternative view of the division in terms of the major programs, most of which cross group lines. Sect. 7 summarizes external interactions including cooperative Rmore » and D programs and technology transfer functions. Finally, Sect. 8 briefly describes the division`s involvement in educational activities. Several organizational changes were effected during this period.« less

  17. Genome organization during the cell cycle: unity in division.

    PubMed

    Golloshi, Rosela; Sanders, Jacob T; McCord, Rachel Patton

    2017-09-01

    During the cell cycle, the genome must undergo dramatic changes in structure, from a decondensed, yet highly organized interphase structure to a condensed, generic mitotic chromosome and then back again. For faithful cell division, the genome must be replicated and chromosomes and sister chromatids physically segregated from one another. Throughout these processes, there is feedback and tension between the information-storing role and the physical properties of chromosomes. With a combination of recent techniques in fluorescence microscopy, chromosome conformation capture (Hi-C), biophysical experiments, and computational modeling, we can now attribute mechanisms to many long-observed features of chromosome structure changes during cell division. Apparent conflicts that arise when integrating the concepts from these different proposed mechanisms emphasize that orchestrating chromosome organization during cell division requires a complex system of factors rather than a simple pathway. Cell division is both essential for and threatening to proper genome organization. As interphase three-dimensional (3D) genome structure is quite static at a global level, cell division provides an important window of opportunity to make substantial changes in 3D genome organization in daughter cells, allowing for proper differentiation and development. Mistakes in the process of chromosome condensation or rebuilding the structure after mitosis can lead to diseases such as cancer, premature aging, and neurodegeneration. WIREs Syst Biol Med 2017, 9:e1389. doi: 10.1002/wsbm.1389 For further resources related to this article, please visit the WIREs website. © 2017 Wiley Periodicals, Inc.

  18. 77 FR 4947 - Proposed Significant New Use Rules on Certain Chemical Substances; Reopening of Comment Period

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-01

    ...), Office of Pollution Prevention and Toxics, Environmental Protection Agency, 1200 Pennsylvania Ave. NW... requirements. Dated: January 24, 2012. Maria J. Doa, Director, Chemical Control Division, Office of Pollution Prevention and Toxics. [FR Doc. 2012-2200 Filed 1-31-12; 8:45 am] BILLING CODE 6560-50-P ...

  19. On the interrelation of multiplication and division in secondary school children.

    PubMed

    Huber, Stefan; Fischer, Ursula; Moeller, Korbinian; Nuerk, Hans-Christoph

    2013-01-01

    Each division problem can be transformed into as a multiplication problem and vice versa. Recent research has indicated strong developmental parallels between multiplication and division in primary school children. In this study, we were interested in (i) whether these developmental parallels persist into secondary school, (ii) whether similar developmental parallels can be observed for simple and complex problems, (iii) whether skill level modulates this relationship, and (iv) whether the correlations are specific and not driven by general cognitive or arithmetic abilities. Therefore, we assessed performance of 5th and 6th graders attending two secondary school types of the German educational system in simple and complex multiplication as well as division while controlling for non-verbal intelligence, short-term memory, and other arithmetic abilities. Accordingly, we collected data from students differing in skills levels due to either age (5th < 6th grade) or school type (general < intermediate secondary school). We observed moderate to strong bivariate and partial correlations between multiplication and division with correlations being higher for simple tasks but nevertheless reliable for complex tasks. Moreover, the association between simple multiplication and division depended on students' skill levels as reflected by school types, but not by age. Partial correlations were higher for intermediate than for general secondary school children. In sum, these findings emphasize the importance of the inverse relationship between multiplication and division which persists into later developmental stages. However, evidence for skill-related differences in the relationship between multiplication and division was restricted to the differences for school types.

  20. Quantum internet using code division multiple access

    PubMed Central

    Zhang, Jing; Liu, Yu-xi; Özdemir, Şahin Kaya; Wu, Re-Bing; Gao, Feifei; Wang, Xiang-Bin; Yang, Lan; Nori, Franco

    2013-01-01

    A crucial open problem inS large-scale quantum networks is how to efficiently transmit quantum data among many pairs of users via a common data-transmission medium. We propose a solution by developing a quantum code division multiple access (q-CDMA) approach in which quantum information is chaotically encoded to spread its spectral content, and then decoded via chaos synchronization to separate different sender-receiver pairs. In comparison to other existing approaches, such as frequency division multiple access (FDMA), the proposed q-CDMA can greatly increase the information rates per channel used, especially for very noisy quantum channels. PMID:23860488

  1. Oriented cell division shapes carnivorous pitcher leaves of Sarracenia purpurea

    PubMed Central

    Fukushima, Kenji; Fujita, Hironori; Yamaguchi, Takahiro; Kawaguchi, Masayoshi; Tsukaya, Hirokazu; Hasebe, Mitsuyasu

    2015-01-01

    Complex morphology is an evolutionary outcome of phenotypic diversification. In some carnivorous plants, the ancestral planar leaf has been modified to form a pitcher shape. However, how leaf development was altered during evolution remains unknown. Here we show that the pitcher leaves of Sarracenia purpurea develop through cell division patterns of adaxial tissues that are distinct from those in bifacial and peltate leaves, subsequent to standard expression of adaxial and abaxial marker genes. Differences in the orientation of cell divisions in the adaxial domain cause bifacial growth in the distal region and adaxial ridge protrusion in the middle region. These different growth patterns establish pitcher morphology. A computer simulation suggests that the cell division plane is critical for the pitcher morphogenesis. Our results imply that tissue-specific changes in the orientation of cell division underlie the development of a morphologically complex leaf. PMID:25774486

  2. Mechanical Forces Program the Orientation of Cell Division during Airway Tube Morphogenesis.

    PubMed

    Tang, Zan; Hu, Yucheng; Wang, Zheng; Jiang, Kewu; Zhan, Cheng; Marshall, Wallace F; Tang, Nan

    2018-02-05

    Oriented cell division plays a key role in controlling organogenesis. The mechanisms for regulating division orientation at the whole-organ level are only starting to become understood. By combining 3D time-lapse imaging, mouse genetics, and mathematical modeling, we find that global orientation of cell division is the result of a combination of two types of spindles with distinct spindle dynamic behaviors in the developing airway epithelium. Fixed spindles follow the classic long-axis rule and establish their division orientation before metaphase. In contrast, rotating spindles do not strictly follow the long-axis rule and determine their division orientation during metaphase. By using both a cell-based mechanical model and stretching-lung-explant experiments, we showed that mechanical force can function as a regulatory signal in maintaining the stable ratio between fixed spindles and rotating spindles. Our findings demonstrate that mechanical forces, cell geometry, and oriented cell division function together in a highly coordinated manner to ensure normal airway tube morphogenesis. Copyright © 2017 Elsevier Inc. All rights reserved.

  3. Luis de Florez and the Special Devices Division

    NASA Astrophysics Data System (ADS)

    Dawson, Paul Louis

    This Dissertation presents the life of Luis de Florez and the World War II history of the Special Devices Division (SDD) of the U.S. Navy's Bureau of Aeronautics. Luis de Florez was a well known consulting engineer, aviation fuel expert, private pilot and reserve Naval officer. While on active duty in 1940, he received the assignment to improve the Navy's flight training methods. To accomplish this objective, he promoted the concept of synthetic training, the use of simulators and other non-operational equipment, to provide training for Navy flight personnel such as pilots, gunners, navigators, flight engineers, radio operators and others as well as for ground based people like mechanics. He founded the Special Devices Division to design the tools and equipment needed for this type of training. The success of synthetic training and the devices developed by the SDD received recognition by the awarding of the Collier Trophy to de Florez in December 1944. This trophy is awarded annually for the most significant aeronautical achievement of the previous year (1943). De Florez received the award for the strategic accomplishment of training thousands of American airmen in 1943. The work of the Division also had other important technical, social, financial and operational impacts on the prosecution of WW II by the Allies. The work of the Division also had impacts on American society as a whole that persist to the present day. These impacts are discussed in detail. The Dissertation presents details of the devices and their use in aviation training as well as a history of the Division during the war. After the war, de Florez led an advisory board for the CIA. These activities and some of both the positive and negative results of the work of this board are discussed. This discussion includes de Florez' involvement in the CIA's drug experiments and the unfortunate Frank Olsen affair.

  4. 49 CFR 176.410 - Division 1.5 materials, ammonium nitrate and ammonium nitrate mixtures.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... (Oxidizers and Organic Peroxides), and Division 1.5 Materials § 176.410 Division 1.5 materials, ammonium...) Ammonium nitrate, Division 5.1 (oxidizer), UN1942. (3) Ammonium nitrate fertilizer, Division 5.1 (oxidizer), UN 2067. (b) This section does not apply to Ammonium nitrate fertilizer, Class 9, UN 2071 or to any...

  5. Fighting blind: why US Army Divisions Need a Dedicated Reconnaissance and Security Force

    DTIC Science & Technology

    2017-05-25

    dedicated reconnaissance and security force. By the 2003 invasion of Iraq, 3d Infantry Division employed a division cavalry squadron that integrated...26 1 Introduction 3-7 Cavalry conducted reconnaissance and security tasks ahead of and on the flank of 3d Infantry Division as the...division led Vth Corp’s attack from Kuwait to Baghdad in 2003. 3-7 Cavalry’s movements confused the enemy about 3d Infantry Division’s location and intent

  6. The mechanisms of labor division from the perspective of individual optimization

    NASA Astrophysics Data System (ADS)

    Zhu, Lirong; Chen, Jiawei; Di, Zengru; Chen, Liujun; Liu, Yan; Stanley, H. Eugene

    2017-12-01

    Although the tools of complexity research have been applied to the phenomenon of labor division, its underlying mechanisms are still unclear. Researchers have used evolutionary models to study labor division in terms of global optimization, but focusing on individual optimization is a more realistic, real-world approach. We do this by first developing a multi-agent model that takes into account information-sharing and learning-by-doing and by using simulations to demonstrate the emergence of labor division. We then use a master equation method and find that the computational results are consistent with the results of the simulation. Finally we find that the core underlying mechanisms that cause labor division are learning-by-doing, information cost, and random fluctuation.

  7. Dynamic self-organisation of haematopoiesis and (a)symmetric cell division.

    PubMed

    Måløy, Marthe; Måløy, Frode; Jakobsen, Per; Olav Brandsdal, Bjørn

    2017-02-07

    A model of haematopoiesis that links self-organisation with symmetric and asymmetric cell division is presented in this paper. It is assumed that all cell divisions are completely random events, and that the daughter cells resulting from symmetric and asymmetric stem cell divisions are, in general, phenotypically identical, and still, the haematopoietic system has the flexibility to self-renew, produce mature cells by differentiation, and regenerate undifferentiated and differentiated cells when necessary, due to self-organisation. As far as we know, no previous model implements symmetric and asymmetric division as the result of self-organisation. The model presented in this paper is inspired by experiments on the Drosophila germline stem cell, which imply that under normal conditions, the stem cells typically divide asymmetrically, whereas during regeneration, the rate of symmetric division increases. Moreover, the model can reproduce several of the results from experiments on female Safari cats. In particular, the model can explain why significant fluctuation in the phenotypes of haematopoietic cells was observed in some cats, when the haematopoietic system had reached normal population level after regeneration. To our knowledge, no previous model of haematopoiesis in Safari cats has captured this phenomenon. Copyright © 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.

  8. Division of Behavioral Health: FAQ

    Science.gov Websites

    State Employees Behavioral Health DHSS State of Alaska Home Divisions and Agencies Alaska Pioneer Homes Behavioral Health Office of Children's Services Office of the Commissioner Office of Substance Misuse and Addiction Prevention Finance & Management Services Health Care Services Juvenile Justice Public

  9. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    sponsors. Distinguish by scope/specific aspects of research; or by institution; or by individual. Example Sciences Division About Organization Contact Research Core Programs Materials Discovery, Design and Postdoc Forum Research Highlights Awards Publications Database Events Calendar Newsletter Archive People

  10. Activities of the Structures Division, Lewis Research Center

    NASA Technical Reports Server (NTRS)

    1990-01-01

    The purpose of the NASA Lewis Research Center, Structures Division's 1990 Annual Report is to give a brief, but comprehensive, review of the technical accomplishments of the Division during the past calendar year. The report is organized topically to match the Center's Strategic Plan. Over the years, the Structures Division has developed the technology base necessary for improving the future of aeronautical and space propulsion systems. In the future, propulsion systems will need to be lighter, to operate at higher temperatures and to be more reliable in order to achieve higher performance. Achieving these goals is complex and challenging. Our approach has been to work cooperatively with both industry and universities to develop the technology necessary for state-of-the-art advancement in aeronautical and space propulsion systems. The Structures Division consists of four branches: Structural Mechanics, Fatigue and Fracture, Structural Dynamics, and Structural Integrity. This publication describes the work of the four branches by three topic areas of Research: (1) Basic Discipline; (2) Aeropropulsion; and (3) Space Propulsion. Each topic area is further divided into the following: (1) Materials; (2) Structural Mechanics; (3) Life Prediction; (4) Instruments, Controls, and Testing Techniques; and (5) Mechanisms. The publication covers 78 separate topics with a bibliography containing 159 citations. We hope you will find the publication interesting as well as useful.

  11. 78 FR 48466 - Hewlett Packard Company, Printing & Personal System Americas Division, Marketing Services...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-08

    ..., Printing & Personal System Americas Division, Marketing Services, Houston, Texas; Notice of Investigation... Division, Marketing Services, Houston, Texas. On January 25, 2013, the Department issued a Notice of... & Personal System Americas Division, Marketing Services, Houston, Texas) to be filed. Because the later-filed...

  12. Environmental Sciences Division annual progress report for period ending September 30, 1991

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Not Available

    1992-04-01

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division of Oak Ridge National Laboratory during the period October 1, 1990, through September 30, 1991. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units is a section devoted to lists of information necessary to convey the scope of the work in the division. The Environmental Sciences Division (ESD) at Oak Ridge National Laboratory (ORNL) conducts environmental research and analyses associated with both energy technology development and themore » interactions between people and the environment. The division engages in basic and applied research for a diverse list of sponsors. While the US Department of Energy (DOE) is the primary sponsor ESD staff also perform research for other federal agencies, state agencies, and private industry. The division works collaboratively with federal agencies, universities, and private organizations in achieving its research objectives and hosts a large number of visiting investigators from these organizations. Given the diverse interdisciplinary specialization of its staff, ESD provides technical expertise on complex environmental problems and renders technical leadership for major environmental issues of national and local concern. This progress report highlights many of ESD`s accomplishment in these and other areas in FY 1991.« less

  13. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except those...

  14. 77 FR 23637 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-20

    ... Airworthiness Directives; Pratt & Whitney Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA... directive (AD) for certain Pratt & Whitney Division PW4000-94'' and PW4000-100'' turbofan engines having a...-flight engine shutdowns, in certain PW4000-94'' and PW4000-100'' turbofan engines. Pratt & Whitney's...

  15. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except those...

  16. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except those...

  17. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Corporation Finance. 200.18 Section 200.18 Commodity and Securities Exchanges SECURITIES AND EXCHANGE... General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of Corporation Finance is responsible to the Commission for the administration of all matters (except those...

  18. MAMMALIAN SCREENING ASSAYS FOR THE DETECTION OF POTENTIAL ENDOCRINE DISRUPTING CHEMICALS WITH AN EMPHASIS ON MALES

    EPA Science Inventory

    MAMMALIAN SCREENING ASSAYS FOR THE DETECTION OF POTENTIAL
    ENDOCRINE DISRUPTING CHEMICALS WITH AN EMPHASIS ON MALES.
    Authors: L E Gray 1 , J Furr 1 , M G Price 2 , C J Wolf 3 and J S Ostby 1
    Institutions: 1. Endocrinology Branch, Reproductive Toxicology Division, NH...

  19. Asymmetric cell division requires specific mechanisms for adjusting global transcription.

    PubMed

    Mena, Adriana; Medina, Daniel A; García-Martínez, José; Begley, Victoria; Singh, Abhyudai; Chávez, Sebastián; Muñoz-Centeno, Mari C; Pérez-Ortín, José E

    2017-12-01

    Most cells divide symmetrically into two approximately identical cells. There are many examples, however, of asymmetric cell division that can generate sibling cell size differences. Whereas physical asymmetric division mechanisms and cell fate consequences have been investigated, the specific problem caused by asymmetric division at the transcription level has not yet been addressed. In symmetrically dividing cells the nascent transcription rate increases in parallel to cell volume to compensate it by keeping the actual mRNA synthesis rate constant. This cannot apply to the yeast Saccharomyces cerevisiae, where this mechanism would provoke a never-ending increasing mRNA synthesis rate in smaller daughter cells. We show here that, contrarily to other eukaryotes with symmetric division, budding yeast keeps the nascent transcription rates of its RNA polymerases constant and increases mRNA stability. This control on RNA pol II-dependent transcription rate is obtained by controlling the cellular concentration of this enzyme. © The Author(s) 2017. Published by Oxford University Press on behalf of Nucleic Acids Research.

  20. Cell and plastid division are coordinated through the prereplication factor AtCDT1

    PubMed Central

    Raynaud, Cécile; Perennes, Claudette; Reuzeau, Christophe; Catrice, Olivier; Brown, Spencer; Bergounioux, Catherine

    2005-01-01

    The cell division cycle involves nuclear and cytoplasmic events, namely organelle multiplication and distribution between the daughter cells. Until now, plastid and plant cell division have been considered as independent processes because they can be uncoupled. Here, down-regulation of AtCDT1a and AtCDT1b, members of the prereplication complex, is shown to alter both nuclear DNA replication and plastid division in Arabidopsis thaliana. These data constitute molecular evidence for relationships between the cell-cycle and plastid division. Moreover, the severe developmental defects observed in AtCDT1-RNA interference (RNAi) plants underline the importance of coordinated cell and organelle division for plant growth and morphogenesis. PMID:15928083

  1. Solid State Division progress report for period ending March 31, 1997

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Green, P.H.; Hinton, L.W.

    1997-12-01

    This report covers research progress in the Solid State Division from April 1, 1995, through March 31, 1997. During this period, the division conducted a broad, interdisciplinary materials research program in support of Department of Energy science and technology missions. The report includes brief summaries of research activities in condensed matter theory, neutron scattering, synthesis and characterization of materials, ion beam and laser processing, and the structure of solids and surfaces. An addendum includes listings of division publications and professional activities.

  2. Advanced Code-Division Multiplexers for Superconducting Detector Arrays

    NASA Astrophysics Data System (ADS)

    Irwin, K. D.; Cho, H. M.; Doriese, W. B.; Fowler, J. W.; Hilton, G. C.; Niemack, M. D.; Reintsema, C. D.; Schmidt, D. R.; Ullom, J. N.; Vale, L. R.

    2012-06-01

    Multiplexers based on the modulation of superconducting quantum interference devices are now regularly used in multi-kilopixel arrays of superconducting detectors for astrophysics, cosmology, and materials analysis. Over the next decade, much larger arrays will be needed. These larger arrays require new modulation techniques and compact multiplexer elements that fit within each pixel. We present a new in-focal-plane code-division multiplexer that provides multiplexing elements with the required scalability. This code-division multiplexer uses compact lithographic modulation elements that simultaneously multiplex both signal outputs and superconducting transition-edge sensor (TES) detector bias voltages. It eliminates the shunt resistor used to voltage bias TES detectors, greatly reduces power dissipation, allows different dc bias voltages for each TES, and makes all elements sufficiently compact to fit inside the detector pixel area. These in-focal plane code-division multiplexers can be combined with multi-GHz readout based on superconducting microresonators to scale to even larger arrays.

  3. Cell division and endoreduplication: doubtful engines of vegetative growth.

    PubMed

    John, Peter C L; Qi, Ruhu

    2008-03-01

    Currently, there is little information to indicate whether plant cell division and development is the collective effect of individual cell programming (cell-based) or is determined by organ-wide growth (organismal). Modulation of cell division does not confirm cell autonomous programming of cell expansion; instead, final cell size seems to be determined by the balance between cells formed and subsequent tissue growth. Control of growth in regions of the plant therefore has great importance in determining cell, organ and plant development. Here, we question the view that formation of new cells and their programmed expansion is the driving force of growth. We believe there is evidence that division does not drive, but requires, cell growth and a similar requirement for growth is detected in the modified cycle termed endoreduplication.

  4. Divisions of geologic time-major chronostratigraphic and geochronologic units

    USGS Publications Warehouse

    ,

    2010-01-01

    Effective communication in the geosciences requires consistent uses of stratigraphic nomenclature, especially divisions of geologic time. A geologic time scale is composed of standard stratigraphic divisions based on rock sequences and is calibrated in years. Over the years, the development of new dating methods and the refinement of previous methods have stimulated revisions to geologic time scales. Advances in stratigraphy and geochronology require that any time scale be periodically updated. Therefore, Divisions of Geologic Time, which shows the major chronostratigraphic (position) and geochronologic (time) units, is intended to be a dynamic resource that will be modified to include accepted changes of unit names and boundary age estimates. This fact sheet is a modification of USGS Fact Sheet 2007-3015 by the U.S. Geological Survey Geologic Names Committee.

  5. The Armored and Mechanized Division Armored Cavalry Squadron

    DTIC Science & Technology

    1977-06-10

    not. You might think some of the historians were speaking today. This review will also attempt to provide a base for further research. HISTORY It is... historians believe the Chinese first used horse mounted soldiers as early as 2b00 B,C, The fighting at the siege of Troy had warrior chiefs called...34 moto -mechanized" divisions, "mobile" divisions, the "Panzer Corps," etc. It seems to be the fashio- of the times to apply a mechanical name to

  6. DOLWD Division of Workers' Compensation

    Science.gov Websites

    ' Compensation Act (Act). The Act provides for the payment by employers or their insurance carriers of medical -related medical and disability benefits. Workers' Compensation also requires the payment of benefits to Workforce Development, Workers' Compensation Division, Medical Services Review Committee will meet June 15

  7. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Synthesis Condensed Matter and Materials Physics Scattering and Instrumentation Science Centers Center for Berkeley Lab Berkeley Lab A-Z Index Phone Book Jobs Search DOE Search MSD Go MSD - Materials Sciences Division About Organization Contact Research Core Programs Materials Discovery, Design and

  8. 77 FR 51459 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-24

    ... Airworthiness Directives; Pratt & Whitney Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA..., PW4460, PW4462, PW4164, PW4164C, PW4164C/B, PW4168, and PW4168A turbofan engines with certain high... ADs None. (c) Applicability This AD applies to the following Pratt & Whitney Division turbofan engines...

  9. Noise and Epigenetic Inheritance of Single-Cell Division Times Influence Population Fitness.

    PubMed

    Cerulus, Bram; New, Aaron M; Pougach, Ksenia; Verstrepen, Kevin J

    2016-05-09

    The fitness effect of biological noise remains unclear. For example, even within clonal microbial populations, individual cells grow at different speeds. Although it is known that the individuals' mean growth speed can affect population-level fitness, it is unclear how or whether growth speed heterogeneity itself is subject to natural selection. Here, we show that noisy single-cell division times can significantly affect population-level growth rate. Using time-lapse microscopy to measure the division times of thousands of individual S. cerevisiae cells across different genetic and environmental backgrounds, we find that the length of individual cells' division times can vary substantially between clonal individuals and that sublineages often show epigenetic inheritance of division times. By combining these experimental measurements with mathematical modeling, we find that, for a given mean division time, increasing heterogeneity and epigenetic inheritance of division times increases the population growth rate. Furthermore, we demonstrate that the heterogeneity and epigenetic inheritance of single-cell division times can be linked with variation in the expression of catabolic genes. Taken together, our results reveal how a change in noisy single-cell behaviors can directly influence fitness through dynamics that operate independently of effects caused by changes to the mean. These results not only allow a better understanding of microbial fitness but also help to more accurately predict fitness in other clonal populations, such as tumors. Copyright © 2016 Elsevier Ltd. All rights reserved.

  10. PROFILE OF THE GULF ECOLOGY DIVISION, UNITED STATES ENVIRONMENTAL PROTECTION AGENCY

    EPA Science Inventory

    A history of the man-made island on which the Gulf Ecology Division is located,from its origin in 1876 to the present day (2007). Contains a synopsis of current research and future plans of the division.

  11. 46 CFR 108.173 - Class I, Division 2 locations.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... m (10 ft.) of a possible source of gas release; or (3) Within 1.5 m (5 ft.) of the boundaries of any...) Within 1.5 m (5 ft.) of a semi-enclosed Class I, Division 1 location indicated in § 108.171(b); or (2) Within 1.5 m (5 ft.) of a Class I, Division 1 space indicated in § 108.171(e). (d) A semi-enclosed area...

  12. 46 CFR 108.173 - Class I, Division 2 locations.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... m (10 ft.) of a possible source of gas release; or (3) Within 1.5 m (5 ft.) of the boundaries of any...) Within 1.5 m (5 ft.) of a semi-enclosed Class I, Division 1 location indicated in § 108.171(b); or (2) Within 1.5 m (5 ft.) of a Class I, Division 1 space indicated in § 108.171(e). (d) A semi-enclosed area...

  13. 46 CFR 108.173 - Class I, Division 2 locations.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... m (10 ft.) of a possible source of gas release; or (3) Within 1.5 m (5 ft.) of the boundaries of any...) Within 1.5 m (5 ft.) of a semi-enclosed Class I, Division 1 location indicated in § 108.171(b); or (2) Within 1.5 m (5 ft.) of a Class I, Division 1 space indicated in § 108.171(e). (d) A semi-enclosed area...

  14. 46 CFR 108.173 - Class I, Division 2 locations.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... m (10 ft.) of a possible source of gas release; or (3) Within 1.5 m (5 ft.) of the boundaries of any...) Within 1.5 m (5 ft.) of a semi-enclosed Class I, Division 1 location indicated in § 108.171(b); or (2) Within 1.5 m (5 ft.) of a Class I, Division 1 space indicated in § 108.171(e). (d) A semi-enclosed area...

  15. 17 CFR 200.18 - Director of Division of Corporation Finance.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Organization and Program Management General Organization § 200.18 Director of Division of Corporation Finance. The Director of the Division of... information statements filed pursuant to section 14(c) of the Act (15 U.S.C. 78n(a), 78n(c)). (4) The...

  16. 77 FR 16967 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-23

    ... Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed..., PW4164C, PW4164C/B, PW4168, and PW4168A turbofan engines with certain high- pressure turbine (HPT) stage 1...) Applicability This AD applies to the following Pratt & Whitney Division turbofan engines: (1) PW4052, PW4152...

  17. 77 FR 54791 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-06

    ... Airworthiness Directives; Pratt & Whitney Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA... & Whitney Division PW4000-94'' and PW4000-100'' turbofan engines having a 1st stage high-pressure turbine... AD will affect 446 P&W PW4000-94'' and PW4000-100'' turbofan engines installed on airplanes of U.S...

  18. First real-time observation of transverse division in azooxanthellate scleractinian corals

    NASA Astrophysics Data System (ADS)

    Tokuda, Yuki; Haraguchi, Hiroko; Ezaki, Yoichi

    2017-02-01

    Asexual reproduction is one of the most important traits in the evolutionary history of corals. No real-time observations of asexual reproduction in azooxanthellate solitary scleractinian corals have been conducted to date. Here, we describe previously unknown aspects of asexual reproduction by using Truncatoflabellum spheniscus (Family Flabellidae) based on observations of transverse division conducted over 1200 days. The findings revealed that (1) transverse division was caused by decalcification; (2) compared to the anthocyathus (upper part of the divided corallum), the soft parts of the anthocaulus (lower part of the divided corallum) were severely damaged and injured during division; (3) these injuries were repaired rapidly; and (4) the anthocaulus regrew and repeatedly produced anthocyathi by means of transverse division. Differences in the patterns of soft-part regeneration and repair, as well as differences in skeletal growth rates between the anthocaulus and the anthocyathus imply that the ecological requirements and reproductive success are different from each other immediately after division. The findings provide important clues for unravelling why asexual reproduction appeared frequently in free-living corals, and the extent to which those modes of reproduction has affected the adaptive and evolutionary success of scleractinian corals throughout the Phanerozoic.

  19. Functional redundancy of division specific penicillin-binding proteins in Bacillus subtilis.

    PubMed

    Sassine, Jad; Xu, Meizhu; Sidiq, Karzan R; Emmins, Robyn; Errington, Jeff; Daniel, Richard A

    2017-10-01

    Bacterial cell division involves the dynamic assembly of a diverse set of proteins that coordinate the invagination of the cell membrane and synthesis of cell wall material to create the new cell poles of the separated daughter cells. Penicillin-binding protein PBP 2B is a key cell division protein in Bacillus subtilis proposed to have a specific catalytic role in septal wall synthesis. Unexpectedly, we find that a catalytically inactive mutant of PBP 2B supports cell division, but in this background the normally dispensable PBP 3 becomes essential. Phenotypic analysis of pbpC mutants (encoding PBP 3) shows that PBP 2B has a crucial structural role in assembly of the division complex, independent of catalysis, and that its biochemical activity in septum formation can be provided by PBP 3. Bioinformatic analysis revealed a close sequence relationship between PBP 3 and Staphylococcus aureus PBP 2A, which is responsible for methicillin resistance. These findings suggest that mechanisms for rescuing cell division when the biochemical activity of PBP 2B is perturbed evolved prior to the clinical use of β-lactams. © 2017 The Authors. Molecular Microbiology published by John Wiley & Sons Ltd.

  20. First real-time observation of transverse division in azooxanthellate scleractinian corals

    PubMed Central

    Tokuda, Yuki; Haraguchi, Hiroko; Ezaki, Yoichi

    2017-01-01

    Asexual reproduction is one of the most important traits in the evolutionary history of corals. No real-time observations of asexual reproduction in azooxanthellate solitary scleractinian corals have been conducted to date. Here, we describe previously unknown aspects of asexual reproduction by using Truncatoflabellum spheniscus (Family Flabellidae) based on observations of transverse division conducted over 1200 days. The findings revealed that (1) transverse division was caused by decalcification; (2) compared to the anthocyathus (upper part of the divided corallum), the soft parts of the anthocaulus (lower part of the divided corallum) were severely damaged and injured during division; (3) these injuries were repaired rapidly; and (4) the anthocaulus regrew and repeatedly produced anthocyathi by means of transverse division. Differences in the patterns of soft-part regeneration and repair, as well as differences in skeletal growth rates between the anthocaulus and the anthocyathus imply that the ecological requirements and reproductive success are different from each other immediately after division. The findings provide important clues for unravelling why asexual reproduction appeared frequently in free-living corals, and the extent to which those modes of reproduction has affected the adaptive and evolutionary success of scleractinian corals throughout the Phanerozoic. PMID:28150745

  1. Home | Division of Cancer Prevention

    Cancer.gov

    Our Research The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into cancer. |

  2. Divisions of geologic time (Bookmark)

    USGS Publications Warehouse

    ,

    2012-05-03

    DescriptionThis bookmark, designed for use with U.S. Geological Survey activities at the second USA Science and Engineering Festival (April 26–29, 2012), is adapted from the more detailed Fact Sheet 2010–3059 "Divisions of Geologic Time." The information that it presents is widely sought by educators and students.

  3. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of Materials Safety Bulletins Archive September 2016 - Hazardous Waste [PDF] July 2016 - When Should You Report - Include Safety Training in On-The-Job Training [PDF] July 2009 - Eye Injury from Corrosive Organic Solvent

  4. Psychological Sciences Division: 1985 Programs.

    ERIC Educational Resources Information Center

    Office of Naval Research, Washington, DC. Psychological Sciences Div.

    This booklet describes research carried out under sponsorship of the Psychological Sciences Division of the U.S. Office of Naval Research during Fiscal Year 1985. The booklet is divided into three programmatic research areas: (1) Engineering Psychology; (2) Personnel and Training; and (3) Group Psychology. Each program is described by an overview…

  5. newsletter | Division of Cancer Prevention

    Cancer.gov

    The Division of Cancer Prevention (DCP) conducts and supports research to determine a person's risk of cancer and to find ways to reduce the risk. This knowledge is critical to making progress against cancer because risk varies over the lifespan as genetic and epigenetic changes can transform healthy tissue into invasive cancer.

  6. Cell cycles and cell division in the archaea.

    PubMed

    Samson, Rachel Y; Bell, Stephen D

    2011-06-01

    Until recently little was known about the cell cycle parameters and division mechanisms of archaeal organisms. Although this is still the case for the majority of archaea, significant advances have been made in some model species. The information that has been gleaned thus far points to a remarkable degree of diversity within the archaeal domain of life. More specifically, members of distinct phyla have very different chromosome copy numbers, replication control systems and even employ distinct machineries for cell division. Copyright © 2011 Elsevier Ltd. All rights reserved.

  7. A crucial step in cell division identified | Center for Cancer Research

    Cancer.gov

    When cell division doesn’t go according to plan, the resulting daughter cells can become unstable or even cancerous. A team of CCR investigators has now discovered a crucial step required for normal cell division to occur. Read more...

  8. GENE ARRAYS FOR ELUCIDATING MECHANISTIC DATA FROM MODELS OF MALE INFERTILITY AND CHEMICAL EXPOSURE IN MICE, RATS AND HUMANS

    EPA Science Inventory

    Gene arrays for elucidating mechanistic data from models of male infertility and chemical exposure in mice, rats and humans
    John C. Rockett and David J. Dix
    Gamete and Early Embryo Biology Branch, Reproductive Toxicology Division, National Health and Environmental Effects ...

  9. Hurricane Research Division of AOML/NOAA

    Science.gov Websites

    Statement The mission of NOAA's Hurricane Research Division (HRD) is to advance the understanding and Learn More. What's New Links of Interest Hurricane Field Program Current Hurricane Data Hurricane FAQ

  10. Symmetric vs. Asymmetric Stem Cell Divisions: An Adaptation against Cancer?

    PubMed Central

    Shahriyari, Leili; Komarova, Natalia L.

    2013-01-01

    Traditionally, it has been held that a central characteristic of stem cells is their ability to divide asymmetrically. Recent advances in inducible genetic labeling provided ample evidence that symmetric stem cell divisions play an important role in adult mammalian homeostasis. It is well understood that the two types of cell divisions differ in terms of the stem cells' flexibility to expand when needed. On the contrary, the implications of symmetric and asymmetric divisions for mutation accumulation are still poorly understood. In this paper we study a stochastic model of a renewing tissue, and address the optimization problem of tissue architecture in the context of mutant production. Specifically, we study the process of tumor suppressor gene inactivation which usually takes place as a consequence of two “hits”, and which is one of the most common patterns in carcinogenesis. We compare and contrast symmetric and asymmetric (and mixed) stem cell divisions, and focus on the rate at which double-hit mutants are generated. It turns out that symmetrically-dividing cells generate such mutants at a rate which is significantly lower than that of asymmetrically-dividing cells. This result holds whether single-hit (intermediate) mutants are disadvantageous, neutral, or advantageous. It is also independent on whether the carcinogenic double-hit mutants are produced only among the stem cells or also among more specialized cells. We argue that symmetric stem cell divisions in mammals could be an adaptation which helps delay the onset of cancers. We further investigate the question of the optimal fraction of stem cells in the tissue, and quantify the contribution of non-stem cells in mutant production. Our work provides a hypothesis to explain the observation that in mammalian cells, symmetric patterns of stem cell division seem to be very common. PMID:24204602

  11. A Description and Comparison of the Perceptions of NCAA Division II and Division III College Presidents Regarding the Impacts of Intercollegiate Athletics at Their Institutions

    ERIC Educational Resources Information Center

    Huffman, Aaron C.

    2013-01-01

    The purpose of this study was to describe and compare the perceptions of NCAA Division II and NCAA Division III college and university presidents regarding the impacts of intercollegiate athletics at their institutions. The data were collected with an anonymous online survey instrument developed by the researcher and sent via email using…

  12. Annual Report: Alaska Division of Vocational Rehabilitation--Fiscal Year 1989.

    ERIC Educational Resources Information Center

    Alaska State Dept. of Education, Juneau. Div. of Vocational Rehabilitation.

    This annual report states the goal of the Alaska Division of Vocational Rehabilitation, which is to provide assistance to those who are vocationally disabled so they can secure and maintain suitable employment. The Director of the Division of Vocational Rehabilitation of the Alaska Department of Education offers an overview of fiscal year 1989…

  13. A genetic screen for temperature-sensitive cell-division mutants of Caenorhabditis elegans.

    PubMed Central

    O'Connell, K F; Leys, C M; White, J G

    1998-01-01

    A novel screen to isolate conditional cell-division mutants in Caenorhabditis elegans has been developed. The screen is based on the phenotypes associated with existing cell-division mutations: some disrupt postembryonic divisions and affect formation of the gonad and ventral nerve cord-resulting in sterile, uncoordinated animals-while others affect embryonic divisions and result in lethality. We obtained 19 conditional mutants that displayed these phenotypes when shifted to the restrictive temperature at the appropriate developmental stage. Eighteen of these mutations have been mapped; 17 proved to be single alleles of newly identified genes, while 1 proved to be an allele of a previously identified gene. Genetic tests on the embryonic lethal phenotypes indicated that for 13 genes, embryogenesis required maternal expression, while for 6, zygotic expression could suffice. In all cases, maternal expression of wild-type activity was found to be largely sufficient for embryogenesis. Cytological analysis revealed that 10 mutants possessed embryonic cell-division defects, including failure to properly segregate DNA, failure to assemble a mitotic spindle, late cytokinesis defects, prolonged cell cycles, and improperly oriented mitotic spindles. We conclude that this approach can be used to identify mutations that affect various aspects of the cell-division cycle. PMID:9649522

  14. 75 FR 11918 - Hewlett Pachard Company, Business Critical Systems, Mission Critical Business Software Division...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-12

    ... Pachard Company, Business Critical Systems, Mission Critical Business Software Division, Openvms Operating... Business Software Division, Openvms Operating System Development Group, Including an Employee Operating Out... Company, Business Critical Systems, Mission Critical Business Software Division, OpenVMS Operating System...

  15. 75 FR 41896 - Colville Indian Precision Pine, Colville Tribal Enterprise Corporation, Wood Products Division...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-19

    ... Pine, Colville Tribal Enterprise Corporation, Wood Products Division, Including On-Site Contract... Tribal Enterprise Corporation Wood Products Division, Omak, Washington. The notice was published in the... Colville Indian Precision Pine, Colville Tribal Enterprise Corporation, Wood Products Division. The...

  16. The DuPont Conference: Implications for the Chemical Technology Curriculum

    NASA Astrophysics Data System (ADS)

    Kenkel, John; Rutledge, Sue; Kelter, Paul B.

    1998-05-01

    Southeast Community College (SCC) hosted the first DuPont Conference for Chemical Technology Education at its Lincoln, Nebraska campus October 4-6, 1997. The conference brought together fourteen practicing chemists and chemistry technicians and five college and university faculty members for the express purpose of suggesting new laboratory activities that would help relate the real world of work to the education of chemical laboratory technicians in community colleges. Participants included seven men and seven women from DuPont, Procter & Gamble, Eastman Chemical, Eastman Kodak, Dow Chemical, Air Products and Chemicals, Monsanto, Union Carbide, the Nebraska Agriculture Laboratory, and the University of Nebraska Biological Process Development Facility, Department of Food Science. The conference, sponsored by the E. I. DuPont DeNemours & Company through a grant awarded to SCC in June 1997, was intended to help further the goals of the two major projects underway at SCC, funded by the National Science Foundation's Advanced Technological Education Program. These projects, dubbed "Assignment: Chemical Technology I and II", or ACT-I and ACT-II, are curriculum and materials development projects. The invited scientists had between 2 and 32 years of experience that ranged from bench work to management levels. Many are or have been active on the national scene as members and officers of the American Chemical Society's Division of Chemical Technicians and the ACS Committee on Technician Activities.

  17. 76 FR 30974 - Jason Incorporated, Janesville Accoustics Division, Subsidiary of Jason Partners Holdings LLC...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-27

    ... of Jason Incorporated, Janesville Acoustics Division, Subsidiary of Jason Partners Holdings LLC... Incorporated, Janesville Acoustics Division, Subsidiary of Jason Partners Holdings LLC to be considered leased... Incorporated, Janesville Acoustics Division, Subsidiary of Jason Partners Holdings LLC. The amended notice...

  18. 76 FR 10394 - Hewlett Packard Company, Enterprise Business Division, Technical Services America, Global Parts...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-24

    ... Packard Company, Enterprise Business Division, Technical Services America, Global Parts Supply Chain Group... Business Division, Technical Services America, Global Parts Supply Chain Group, Including Leased Workers... Packard Company, Enterprise Business Division, Technical Services America, Global Parts Supply Chain Group...

  19. Evaluation of Corrective Action Team (CAT) Leader Training in Aeronautical Systems Division

    DTIC Science & Technology

    1991-09-01

    00A DI EVALUATION OF CORRECTIVE ACTION TEAM ( CAT ) LEADER TRAINING IN AERONAUTICAL SYSTEMS DIVISION CA THESIS Kirk J. Streitrater, Captain, USAF AFIT...EVALUATION OF CORRECTIVE ACTION TEAM ( CAT ) LEADER TRAINING IN AERONAUTICAL SYSTEMS DIVISION THESIS Kirk J. Streitmater, Captain, USAF AFIT/GSM/LSR/91S-25...8217, , C- s :C AFIT/GSM/LSR/91S-25 EVALUATION OF CORRECTIVE ACTION TEAM ( CAT ) LEADER TRAINING IN AERONAUTICAL SYSTEMS DIVISION THESIS Presented to the

  20. NEN Division Funding Gap Analysis

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    Esch, Ernst I.; Goettee, Jeffrey D.; Desimone, David J.

    The work in NEN Division revolves around proliferation detection. The sponsor funding model seems to have shifted over the last decades. For the past three lustra, sponsors are mainly interested in funding ideas and detection systems that are already at a technical readiness level 6 (TRL 6 -- one step below an industrial prototype) or higher. Once this level is reached, the sponsoring agency is willing to fund the commercialization, implementation, and training for the systems (TRL 8, 9). These sponsors are looking for a fast turnaround (1-2 years) technology development efforts to implement technology. To support the critical nationalmore » and international needs for nonprolifertion solutions, we have to maintain a fluent stream of subject matter expertise from the fundamental principals of radiation detection through prototype development all the way to the implementation and training of others. NEN Division has large funding gaps in the Valley of Death region. In the current competitive climate for nuclear nonproliferation projects, it is imminent to increase our lead in this field.« less

  1. Language and Literature Division, Faculty of Education, Hong Kong University

    ERIC Educational Resources Information Center

    Qin, Xie; Andrews, Stephen

    2010-01-01

    The Language and Literature Division (LLD) is the largest of the six divisions of the Faculty of Education, University of Hong Kong (HKU). It is currently home to 34 academic staff, who specialize either in the fields of Chinese Language, English Language and/or Literature Education, and to 60 full-time and 28 part-time doctoral students, who are…

  2. Publications - PDF 98-36A | Alaska Division of Geological & Geophysical

    Science.gov Websites

    Oxides; Rocks; STATEMAP Project; Trace Elements Top of Page Department of Natural Resources, Division of Surveys Skip to content State of Alaska myAlaska My Government Resident Business in Alaska Visiting Alaska State Employees DGGS State of Alaska search Alaska Division of Geological & Geophysical

  3. 76 FR 81986 - Honeywell International, Inc., Automation and Control Solutions Division, Including On-Site...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-29

    ..., Inc., Automation and Control Solutions Division, Including On-Site Leased Workers From Manpower... International, Inc., Automation and Control Solutions Division, Rock Island, Illinois. The notice was published...., Automation and Control Solutions Division. The Department has determined that these workers were sufficiently...

  4. 75 FR 5146 - Hewlett Packard Company Business Critical Systems, Mission Critical Business Software Division...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-02-01

    ... Packard Company Business Critical Systems, Mission Critical Business Software Division, OpenVMS Operating... Software Division, OpenVMS Operating System Development Group, Including an Employee Operating Out of the..., Mission Critical Business Software Division, OpenVMS Operating System Development Group, including...

  5. Examining Middle School Pre-Service Teachers' Knowledge of Fraction Division Interpretations

    ERIC Educational Resources Information Center

    Alenazi, Ali

    2016-01-01

    This study investigated 11 pre-service middle school teachers' solution strategies for exploring their knowledge of fraction division interpretations. Each participant solved six fraction division problems. The problems were organized into two sets: symbolic problems (involving numbers only) and contextual problems (involving measurement…

  6. Polarization division multiplexing for optical data communications

    NASA Astrophysics Data System (ADS)

    Ivanovich, Darko; Powell, Samuel B.; Gruev, Viktor; Chamberlain, Roger D.

    2018-02-01

    Multiple parallel channels are ubiquitous in optical communications, with spatial division multiplexing (separate physical paths) and wavelength division multiplexing (separate optical wavelengths) being the most common forms. Here, we investigate the viability of polarization division multiplexing, the separation of distinct parallel optical communication channels through the polarization properties of light. Two or more linearly polarized optical signals (at different polarization angles) are transmitted through a common medium, filtered using aluminum nanowire optical filters fabricated on-chip, and received using individual silicon photodetectors (one per channel). The entire receiver (including optics) is compatible with standard CMOS fabrication processes. The filter model is based upon an input optical signal formed as the sum of the Stokes vectors for each individual channel, transformed by the Mueller matrix that models the filter proper, resulting in an output optical signal that impinges on each photodiode. The results show that two- and three-channel systems can operate with a fixed-threshold comparator in the receiver circuit, but four-channel systems (and larger) will require channel coding of some form. For example, in the four-channel system, 10 of 16 distinct bit patterns are separable by the receiver. The model supports investigation of the range of variability tolerable in the fabrication of the on-chip polarization filters.

  7. U.S. Army Chemical Corps Historical Studies, Gas Warfare in World War I: The 78th Division at the Kriemhilde Stellung, October 1918

    DTIC Science & Technology

    1957-07-01

    on 2 November, the 155th Brigade moved out of the Bois des Loges, by noon had passed through Beffu et le Horthomme, and by 5«30 porno had taken...ammunition was found, also many deserted dugouts and a few wagon oartso We arrived back at 4tl5 porno ™ The next day, the Division Gas Officer, In

  8. Division Artillery: Linking Strategy to Tactics

    DTIC Science & Technology

    2017-05-25

    operational artist, while within modularity , there is no advocate for ensuring that subordinate field artillery units are getting the manning...adaptability, and synchronization. The division artillery is the operational artist, while within modularity , there is no advocate for ensuring...30 Modularization

  9. OVERVIEW -- SUBSURFACE PROTECTION AND REMEDIATION DIVISION

    EPA Science Inventory

    NRMRL's Subsurface Protection and Remediation Division located in Ada, Oklahoma, conducts EPA-investigator led laboratory and field research to provide the scientific basis to support the development of strategies and technologies to protect and restore ground and surface water q...

  10. Fractions division knowledge of elementary school student: The case of Lala

    NASA Astrophysics Data System (ADS)

    Purnomo, Yoppy Wahyu; Widowati, Chairunnisa; Aziz, Tian Abdul; Pramudiani, Puri

    2017-08-01

    Division of fractions is often acknowledged by mysterious rule which is not based on conceptual knowledge. The purpose of the study was to explore elementary school student's knowledge of division fractions. For this purpose, a case study was conducted. The participant of the study was Lala (pseudonym) who enrolled at one elementary school in East Jakarta. The data were collected by administering written test and semi-structured interview respectively. The findings of the study indicated that Lala was able to describe strategy of division fractions as inverse of repeated addition flexibly. She also had basic understanding of fractions division concept as equal sharing, but when she was challenged with advance problems, she performed poorly. Lala also encountered difficulty when dealing with dividing fraction by fraction problem in which she interpreted it as subtraction problem. In this case, her procedural knowledge was likely to be more salient than her conceptual knowledge.

  11. Mentoring for population health in general practice divisions.

    PubMed

    Moss, John R; Mickan, Sharon M; Fuller, Jeffrey D; Procter, Nicholas G; Waters, Barb A; O'Rourke, Peter K

    2006-02-01

    This paper describes the implementation and evaluation of a three-way model of service development mentoring. This population health mentoring program was funded by the Commonwealth Department of Health and Ageing to enable staff from eight Divisions of General Practice in South Australia to gain a sound understanding of population health concepts relevant to their workplace. The distinguishing features of service development mentoring were that the learning was grounded within an individual's work setting and experience; there was an identified population health problem or issue confronting the Division of General Practice; and there was an expectation of enhanced organisational performance. A formal evaluation found a consensus among all learners that mentoring was a positive and worthwhile experience, where they had achieved what they had set out to do. Mentors found the model of learning agreeable and effective. Division executive officers recognised enhanced skills among their "learner" colleagues, and commented positively on the benefits to their organisations through the development of well researched and relevant projects, with the potential to improve the efficiency of their population health activities.

  12. Cell division and the ESCRT complex: A surprise from the archaea.

    PubMed

    Ettema, Thijs Jg; Bernander, Rolf

    2009-01-01

    The Archaea constitute the third domain of life, a separate evolutionary lineage together with the Bacteria and the Eukarya.1 Species belonging to the Archaea contain a surprising mix of bacterial (metabolism, life style, genomic organization) and eukaryotic (replication, transcription, translation) features.2 The archaeal kingdom comprises two main phyla, the Crenarchaeota and the Euryarchaeota. Regarding the cell division process in archaeal species (reviewed in ref. 3), members of the Euryarchaeota rely on an FtsZ-based cell division mechanism4 whereas, previously, no division genes had been detected in the crenarchaea. However, we recently reported the discovery of the elusive cell division machinery in crenarchaea from the genus Sulfolobus.5 The minimal machinery consists of three genes, which we designated cdvA, B and C (for cell division), organized into an operon that is widely conserved among crenarchaea. The gene products polymerize between segregating nucleoids at the early mitotic stage, forming a complex that remains associated with the leading edge of constriction throughout cytokinesis. Interestingly, CdvB and CdvC were shown to be related to the eukaryotic ESCRT-III protein sorting machinery (reviewed in ref. 6), indicating shared common ancestry and mechanistic similarities to endosomal vesicle formation and viral (HIV) budding in eukaryotes. We also demonstrated that the cdv operon is subject to checkpoint-like regulation, and that the genes display a complementary phylogenetic distribution within the Archaea domain relative to FtsZ-dependent division systems.5 Here, the findings are further explored and discussed, and topics for further investigation are suggested.

  13. Environmental Sciences Division annual progress report for period ending September 30, 1994

    DOE Office of Scientific and Technical Information (OSTI.GOV)

    NONE

    1994-12-31

    This progress report summarizes the research and development activities conducted in the Environmental Sciences Division (ESD) of Oak Ridge National Laboratory during fiscal year (FY) 1994, which extended from October 1, 1993, through September 30, 1994. The report is structured to provide descriptions of current activities and accomplishments in each of the division`s major organizational units. Following the sections describing the organizational units are sections highlighting ESD Scientific, Technical, and Administrative Achievement awards and listing information necessary to covey the scope of the work in the division. An organizational chart of staff and long-term guests who wee in ESD atmore » the end of FY 1994 is located in the final section of the report.« less

  14. Combination of Synthetic Chemistry and Live-Cell Imaging Identified a Rapid Cell Division Inhibitor in Tobacco and Arabidopsis thaliana.

    PubMed

    Nambo, Masakazu; Kurihara, Daisuke; Yamada, Tomomi; Nishiwaki-Ohkawa, Taeko; Kadofusa, Naoya; Kimata, Yusuke; Kuwata, Keiko; Umeda, Masaaki; Ueda, Minako

    2016-11-01

    Cell proliferation is crucial to the growth of multicellular organisms, and thus the proper control of cell division is important to prevent developmental arrest or overgrowth. Nevertheless, tools for controlling cell proliferation are still poor in plant. To develop novel tools, we focused on a specific compound family, triarylmethanes, whose members show various antiproliferative activities in animals. By combining organic chemistry to create novel and diverse compounds containing the triarylmethyl moiety and biological screens based on live-cell imaging of a fluorescently labeled tobacco Bright Yellow-2 (BY-2) culture cell line (Nicotiana tabacum), we isolated (3-furyl)diphenylmethane as a strong but partially reversible inhibitor of plant cell division. We also found that this agent had efficient antiproliferative activity in developing organs of Arabidopsis thaliana without causing secondary defects in cell morphology, and induced rapid cell division arrest independent of the cell cycle stage. Given that (3-furyl)diphenylmethane did not affect the growth of a human cell line (HeLa) and a budding yeast (Saccharomyces cerevisiae), it should act specifically on plants. Taking our results together, we propose that the combination of desired chemical synthesis and detailed biological analysis is an effective tool to create novel drugs, and that (3-furyl)diphenylmethane is a specific antiproliferative agent for plants. © The Author 2016. Published by Oxford University Press on behalf of Japanese Society of Plant Physiologists. All rights reserved. For permissions, please email: journals.permissions@oup.com.

  15. Berkeley Lab - Materials Sciences Division

    Science.gov Websites

    Investigators Division Staff Facilities and Centers Staff Jobs Safety Personnel Resources Committees In Case of ? Click Here! Personnel Safety Personnel MSD EH&S Manager Martin Neitzel 66-242 ext. 6169 MLNeitzel Schwartz 66-250E ext. 4957 nischwartz@lbl.gov Lab Safety Advisory Committee Rep Robert Kaindl 2-354 ext

  16. 78 FR 775 - Goodman Networks, Inc. Core Network Engineering (Deployment Engineering) Division Alpharetta, GA...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-04

    ...,846B; TA-W-81,846C; TA-W-81,846D] Goodman Networks, Inc. Core Network Engineering (Deployment Engineering) Division Alpharetta, GA; Goodman Networks, Inc. Core Network Engineering (Deployment Engineering) Division Hunt Valley, MD; Goodman Networks, Inc. Core Network Engineering (Deployment Engineering) Division...

  17. Tissue damage-induced intestinal stem cell division in Drosophila

    PubMed Central

    Amcheslavsky, Alla; Jiang, Jin; Ip, Y. Tony

    2009-01-01

    SUMMARY Stem cell division is essential for tissue integrity during growth, aging, and pathogenic assaults. Adult gastrointestinal tract encounters numerous stimulations and impaired tissue regeneration may lead to inflammatory diseases and cancer. Intestinal stem cells in adult Drosophila have recently been identified and shown to replenish the various cell types within the midgut. However, it is not known whether these intestinal stem cells can respond to environmental challenges. By feeding dextran sulfate sodium and bleomycin to flies and by expressing apoptotic proteins, we show that Drosophila intestinal stem cells can increase the rate of division in response to tissue damage. Moreover, if tissue damage results in epithelial cell loss, the newly formed enteroblasts can differentiate into mature epithelial cells. By using this newly established system of intestinal stem cell proliferation and tissue regeneration, we find that the insulin receptor signaling pathway is required for intestinal stem cell division. PMID:19128792

  18. Thursday's Agenda | Division of Cancer Prevention

    Cancer.gov

    TimeAgenda8:30 am - 8:50 amRegistration - Networking8:50 am - 8:55 amWelcome and Opening RemarksLeslie Ford, MDAssociate Director for Clinical ResearchDivision of Cancer Prevention, NCIEva Szabo, MD Chief, Lung and Upper Aerodigestive Cancer Research Group |

  19. 78 FR 16620 - Airworthiness Directives; Pratt & Whitney Division Turbofan Engines

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-18

    ... Division Turbofan Engines AGENCY: Federal Aviation Administration (FAA), DOT. ACTION: Notice of proposed... Division (PW) turbofan engine models PW4074, PW4074D, PW4077, PW4077D, PW4084D, PW4090, and PW4090-3 with a... proposed AD. Discussion We propose to adopt a new AD for all PW turbofan engine models PW4074, PW4074D...

  20. 46 CFR 42.09-5 - All vessels-division into types.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 2 2010-10-01 2010-10-01 false All vessels-division into types. 42.09-5 Section 42.09-5... BY SEA Load Line Assignments and Surveys-General Requirements § 42.09-5 All vessels—division into types. (a) For the purposes of this part, each vessel to which this part applies is either a Type “A” or...