Note: This page contains sample records for the topic chinese classical hodgkin from
While these samples are representative of the content of,
they are not comprehensive nor are they the most current set.
We encourage you to perform a real-time search of
to obtain the most current and comprehensive results.
Last update: August 15, 2014.

Treating Classic Hodgkin Disease, by Stage  


... nodular lymphocyte predominant Hodgkin disease (NLPHD) Treating classic Hodgkin disease, by stage This section sums up the ... antibody brentuximab vedotin may be another option. Resistant Hodgkin disease Treatment for HD should remove all traces ...


Immunological Deregulation in Classic Hodgkin Lymphoma  

PubMed Central

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications.

Romano, Alessandra; Vetro, Calogero; Caocci, Giovanni; Greco, Marianna; Parrinello, Nunziatina Laura; Di Raimondo, Francesco; La Nasa, Giorgio



Immunological deregulation in classic hodgkin lymphoma.  


Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications. PMID:24959336

Romano, Alessandra; Vetro, Calogero; Caocci, Giovanni; Greco, Marianna; Parrinello, Nunziatina Laura; Di Raimondo, Francesco; La Nasa, Giorgio



Classical Hodgkin’s Lymphoma: Molecular Evidence for Specific Alterations in Circulating T Lymphocytes  

Microsoft Academic Search

Objective: Impairment in cell-mediated immunity has long been recognized in classical Hodgkin’s lymphoma (cHL). The immunosuppressive environment at the tumor site and\\/or a primary T-cell defect may contribute to an ineffective immune clearance of Hodgkin\\/Reed-Sternberg (H\\/R-S) cells. Here, we analyzed whether circulating T lymphocytes of cHL patients show specific alterations in gene expression with possible impact on anti-tumor immunity. Material

Anke Franzke; Christian Koenecke; Robert Geffers; Wenji Piao; J. Katrin Hunger; Arnold Ganser; Jan Buer



Targetable oncogenic pathways in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma  

Microsoft Academic Search

Summary  Classical Hodgkin lymphoma is a lymphoid neoplasm consisting of mononuclear Hodgkin and multinuclear Reed-Sternberg cells,\\u000a mostly of B-cell origin, embedded in a non-neoplastic background. Most patients are cured with the current risk- and response\\u000a adapted therapy, albeit a portion of patients either will fail to respond or will relapse. An important drawback, considering\\u000a the healed individuals, is the increasing late

A. Tzankov



Classical Hodgkin's disease. Clinical impact of the immunophenotype.  

PubMed Central

Antibodies against CD15, -30, and -20 are often used to support morphological diagnosis of Hodgkin's Disease (HD). The classical HD, i.e., the non-lymphocyte-predominance types, are CD15+, CD30+, and CD20- in general. However, the results for CD15 are less clear-cut in many studies, showing up to 40% of classical HD that lack positivity for this maker. Little is currently known about the relevance of antigen expression in relation to clinical outcome in HD. Therefore, the three markers were analyzed in 1751 cases from the German Hodgkin Study Group, using micro-wave epitope retrieval to optimize staining sensitivity. Eighty-three percent of the cases showed a classical immunophenotype (CD15+, CD30+, CD20-), twelve percent lacked CD15 positivity (CD15-, CD30+, CD20-), and five percent showed other combinations. For 1286 cases, clinical follow-up was available, which revealed significant differences for freedom from treatment failure (P = 0.0022) and overall survival (P = 0.0001) between cases with classical immunophenotype and CD15 negativity (CD30+, CD20-). Multivariate Cox regression using the three markers, age, sex, histology, stage, B-symptoms (fever, sweats, weight loss > 10% of body weight), hemoglobin, and erythrocyte sedimentation rate as factors showed that lack of CD15 expression in classical HD is an independent negative prognostic factor for relapses (P = 0.022) and survival (P = 0.0035). In conclusion, immunohistochemistry is able to identify classical HD cases with unfavorable clinical outcome. Images Figure 5 Figure 6

von Wasielewski, R.; Mengel, M.; Fischer, R.; Hansmann, M. L.; Hubner, K.; Franklin, J.; Tesch, H.; Paulus, U.; Werner, M.; Diehl, V.; Georgii, A.



Predicting treatment outcome in classical Hodgkin lymphoma: genomic advances  

PubMed Central

Classical Hodgkin lymphoma is considered a highly curable disease; however, 20% of patients cannot be cured with standard first-line chemotherapy and have a dismal outcome. Current clinical parameters do not allow accurate risk stratification, and personalized therapies are lacking. In fact, Hodgkin lymphoma (HL) is often over- or undertreated because of this lack of accurate risk stratification. In recent years, the early detection of chemoresistance by fluorodeoxyglucose positron emission tomography has become the most important prognostic tool in the management of HL. However, to date, no prognostic scores or molecular markers are available for the early identification of patients at very high risk of failure of induction therapy. In the last decade, many important advances have been made in understanding the biology of HL. In particular, the development of new molecular profiling technologies, such as SNP arrays, comparative genomic hybridization, and gene-expression profiling, have allowed the identification of new prognostic factors that may be useful for risk stratification and predicting response to chemotherapy. In this review, we focus on the prognostic tools and biomarkers that are available for newly diagnosed HL, and we highlight recent advances in the genomic characterization of classical HL and potential targets for therapy.



Imbalances of chemokines, chemokine receptors and cytokines in Hodgkin lymphoma: classical Hodgkin lymphoma vs. Hodgkin-like ATLL.  


Classical Hodgkin lymphoma (HL) is characterized by the presence of Hodgkin and Reed-Sternberg cells (H&RS) and a prominent lymphocytic infiltration. We previously reported Hodgkin-like adult T-cell leukemia/lymphoma (HL-like ATLL) (new WHO classification). Various CXC and CC chemokines are expressed on H&RS cells and the relationships between chemokines and the chemokine receptor (R) are thought to be important for selectivity of local immunity of Th1 and Th2 T cells. To clarify the role of T-cell immunity in classical HL and Hodgkin-like ATLL, we performed gene expression profiling (chemokine, chemokine R and cytokine DNA chips) in 12 cases [classical HL, 8 cases [mixed cellularity (MC) type, 4; nodular sclerosis (NS) type, 4]; Hodgkin-like ATLL, 4 cases] and immunohistochemical staining in 29 cases (MC, 10; NS, 10; Hodgkin-like ATLL, 9). EBV-infected H&RS cells were detected in 9 of 10 cases of HL MC, 5 of 9 of HL-like ATLL and 2 of 10 HL NS. T-cell-directed chemokine thymus- and activation-regulated chemokine (TARC)- and/or macrophage-derived chemokine (MDC)-positive H&RS cells were detected in all 20 cases of HL MC and HL NS but only in 5 of 9 cases of HL-like ATLL. Interferon-gamma-inducible protein-10 (IP10)- and monokine induced by interferon-gamma (MIG)-positive H&RS cells were detected in all 10 HL MC but only in 5 of 10 cases of HL NS and 2 of 9 cases of HL-like ATLL. However, 2 of 5 cases of HL-like ATLL with EBV infection and 2 of 2 HL NS with EBV had IP10/MIG-positive H&RS cells. The chemokine expressions in H&RS cells seemed to be associated with EBV infection rather than histologic subtypes. In the DNA chip expression analysis, classical HL and HL-like ATLL had a mixed Th1/Th2-type profile, and HL MC (EBV-positive) and HL NS (EBV-negative) were differentially clustered. However, 2 cases of HL-like ATLL clustered with HL MS and the other 2 cases of HL-like ATLL clustered with HL NS. The former HL-like ATLL had EBV infection in H&RS cells, whereas the latter did not have EBV infection. This finding also suggests that EBV might influence local expression of chemokines rather than HL subtypes. Our results indicate that local immunologic disorder or imbalance appears to influence the formation of H&RS cells and that in HL-like ATLL, HTLV-1 infection might not be necessary for H&RS cell formation. PMID:12866030

Ohshima, Koichi; Karube, Kennosuke; Hamasaki, Makoto; Suefuji, Hiroaki; Tutiya, Takeshi; Yamaguchi, Takahiro; Suzumiya, Junji; Kikuchi, Masahiro



The FOXP1 Transcription Factor is Expressed in the Majority of Follicular Lymphomas but is Rarely Expressed in Classical and Lymphocyte Predominant Hodgkin’s Lymphoma  

Microsoft Academic Search

Summary  The expression of the FOXP1 forkhead\\/winged helix transcription factor has been investigated in normal and neoplastic lymphoid tissues using the FOXP1-specific\\u000a monoclonal antibody, JC12. Using single and double immunoenzymatic staining, FOXP1 expression has been studied in a series\\u000a of classical and lymphocyte predominant Hodgkin’s lymphomas, follicle centre lymphomas and Hodgkin’s lymphoma-derived cell\\u000a lines. Neoplastic cells in the majority of classical

Philip Brown; Teresa Marafioti; Rajko Kusec; Alison H. Banham



Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma  

PubMed Central

Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma.

Campos, Antonio Hugo; Vassallo, Jose; Soares, Fernando Augusto



Hodgkin Reed-Sternberg cells express 15-lipoxygenase-1 and are putative producers of eoxins in vivo: novel insight into the inflammatory features of classical Hodgkin lymphoma.  


Classical Hodgkin lymphoma has unique clinical and pathological features and tumour tissue is characterized by a minority of malignant Hodgkin Reed-Sternberg cells surrounded by inflammatory cells. In the present study, we report that the Hodgkin lymphoma-derived cell line L1236 has high expression of 15-lipoxygenase-1 and that these cells readily convert arachidonic acid to eoxin C(4), eoxin D(4) and eoxin E(4). These mediators were only recently discovered in human eosinophils and mast cells and found to be potent proinflammatory mediators. Western blot and immunocytochemistry analyses of L1236 cells demonstrated that 15-lipoxygenase-1 was present mainly in the cytosol and that the enzyme translocated to the membrane upon calcium challenge. By immunohistochemistry of Hodgkin lymphoma tumour tissue, 15-lipoxygenase-1 was found to be expressed in primary Hodgkin Reed-Sternberg cells in 17 of 20 (85%) investigated biopsies. The enzyme 15-lipoxygenase-1, however, was not expressed in any of 10 biopsies representing nine different subtypes of non-Hodgkin lymphoma. In essence, the expression of 15-lipoxygenase-1 and the putative formation of eoxins by Hodgkin Reed-Sternberg cells in vivo are likely to contribute to the inflammatory features of Hodgkin lymphoma. These findings may have important diagnostic and therapeutic implications in Hodgkin lymphoma. Furthermore, the discovery of the high 15-lipoxygenase-1 activity in L1236 cells demonstrates that this cell line comprises a useful model system to study the chemical and biological roles of 15-lipoxygenase-1. PMID:18647347

Claesson, Hans-Erik; Griffiths, William J; Brunnström, Asa; Schain, Frida; Andersson, Erik; Feltenmark, Stina; Johnson, Hélène A; Porwit, Anna; Sjöberg, Jan; Björkholm, Magnus



Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type  

PubMed Central

Background Classical Hodgkin’s lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin’s lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin’s lymphoma remain controversial. Design and Methods We investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin’s lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic molecule-negative Hodgkin’s lymphoma. Results The patients with cytotoxic molecule-positive Hodgkin’s lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin’s lymphoma had a prototypic immunophenotype of CD15+ CD30+ CD45RO? fascin+, with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin’s lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin’s lymphoma. Regarding prognosis, the survival of patients with cytotoxic molecule-positive Hodgkin’s lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin’s lymphoma (P=0.0003) but better than that of patients with cytotoxic molecule-positive peripheral T-cell lymphomas, not otherwise specified (P=0.002). Conclusions Cytotoxic molecule-positive Hodgkin’s lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin’s lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin’s lymphoma is clearly required.

Asano, Naoko; Kinoshita, Tomohiro; Tamaru, Jun-Ichi; Ohshima, Koichi; Yoshino, Tadashi; Niitsu, Nozomi; Tsukamoto, Norifumi; Hirabayashi, Kaoru; Izutsu, Koji; Taniwaki, Masafumi; Morishima, Yasuo; Nakamura, Shigeo



Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis.  


Due to disease rarity, there is limited information regarding the optimal therapy and outcome for patients with advanced-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Forty-two patients with NLPHL by the Revised European-American Lymphoma/World Health Organization classification with advanced-stage disease were identified and paired 1:2 with a matched control with classical Hodgkin lymphoma (CHL) matched by age, gender, stage, decade of diagnosis, and treatment received. The median follow-up was 11.3 years (range, 1.9 to 35.5 years) for NLPHL patients and 10.7 years (range, 1.6 to 26.3 years) for CHL patients. The majority received doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)-like chemotherapy. Although the 10-year overall survival (OS) (P = .579) and HL freedom from treatment failure (HL-FFTF) were similar between NLPHL and CHL patients (75% vs 73%; P = .610), the time to progression (TTP), which also includes the development of secondary aggressive lymphoma, was inferior in NLPHL (10-year, 63% vs 73%; P = .040). Splenic involvement was associated with an inferior 10-year TTP in patients treated with ABVD (48% vs 71%; P = .049) and an increased cumulative incidence of secondary aggressive lymphoma (P = .014) providing a rationale for further evaluation of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab in NLPHL. PMID:24713929

Xing, Katharine H; Connors, Joseph M; Lai, Anky; Al-Mansour, Mubarak; Sehn, Laurie H; Villa, Diego; Klasa, Richard; Shenkier, Tamara; Gascoyne, Randy D; Skinnider, Brian; Savage, Kerry J



Coexistence of marginal zone cutaneous B-cell lymphoma and classic Hodgkin disease: does a biological relationship exist?  


The coexistence of non-Hodgkin lymphoma (NHL) and Hodgkin disease (HD) in the same patient, although previously reported, is very unusual. This situation is extremely rare when the first diagnosis is a cutaneous B NHL, and exceptional if there is no personal background of cytostatic treatment. We report a 44-year-old man who developed cutaneous nodules over a period of two years. A marginal zone cutaneous B-cell lymphoma was diagnosed. On staging investigation a mass in the lingual tonsil was found and excision biopsy showed a classical Hodgkin lymphoma. PMID:23551363

Gallo, E; Pérez-Gala, S; Navarro, R; Fraga, J; Adrados, M; Arranz, R; García-Diez, A; Aragüés, M



Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas  

PubMed Central

We have shown previously that cancer/testis (CT) antigen, CT45, is expressed in various epithelial cancers at a frequency of <5% to ?35%. In this study, the protein expression of CT45 was examined in non-Hodgkin B-cell lymphomas and classical Hodgkin lymphoma by immunohistochemical analysis. Serological response to CT45 was also evaluated by ELISA using CT45 recombinant protein and sera from patients with Hodgkin lymphoma. None of the 80 low-grade B-cell lymphomas, including chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma, expressed CT45. In comparison, CT45 was expressed in 28 of 126 (22%) diffuse large B-cell lymphomas (DLBCL). A remarkably high percentage (42/72, 58%) of classical Hodgkin lymphoma contained CT45-positive Reed–Sternberg cells. Nodular sclerosis and mixed-cellularity subtypes had similar frequency of CT45 expression, but most EBV-positive cases were CT45 negative. Gray-zone lymphoma (cases with features of both DLBCL and classical Hodgkin lymphoma) also showed frequent (64%) CT45 expression. Evaluation of reactive lymphoid tissues showed scattered CT45-positive lymphocytes in a single case of florid follicular hyperplasia, raising the possibility that this case was an evolving malignancy. Despite frequent CT45 expression, only 1 of 67 Hodgkin lymphoma patients had detectable anti-CT45 antibodies in the serum, suggesting that the immune response to CT45 may be suppressed. In conclusion, classical Hodgkin lymphoma has the highest frequency of CT45 expression among all malignancies tested to date, the frequency of CT45 expression in DLBCL is similar to that seen in epithelial cancers, and low-grade non-Hodgkin B-cell lymphomas do not express CT45.

Chen, Yao-Tseng; Chadburn, Amy; Lee, Peishan; Hsu, Melinda; Ritter, Erika; Chiu, April; Gnjatic, Sacha; Pfreundschuh, Michael; Knowles, Daniel M.; Old, Lloyd J.



Expression of cancer testis antigen CT45 in classical Hodgkin lymphoma and other B-cell lymphomas.  


We have shown previously that cancer/testis (CT) antigen, CT45, is expressed in various epithelial cancers at a frequency of <5% to approximately 35%. In this study, the protein expression of CT45 was examined in non-Hodgkin B-cell lymphomas and classical Hodgkin lymphoma by immunohistochemical analysis. Serological response to CT45 was also evaluated by ELISA using CT45 recombinant protein and sera from patients with Hodgkin lymphoma. None of the 80 low-grade B-cell lymphomas, including chronic lymphocytic leukemia/small lymphocytic lymphoma, follicular lymphoma, and mantle cell lymphoma, expressed CT45. In comparison, CT45 was expressed in 28 of 126 (22%) diffuse large B-cell lymphomas (DLBCL). A remarkably high percentage (42/72, 58%) of classical Hodgkin lymphoma contained CT45-positive Reed-Sternberg cells. Nodular sclerosis and mixed-cellularity subtypes had similar frequency of CT45 expression, but most EBV-positive cases were CT45 negative. Gray-zone lymphoma (cases with features of both DLBCL and classical Hodgkin lymphoma) also showed frequent (64%) CT45 expression. Evaluation of reactive lymphoid tissues showed scattered CT45-positive lymphocytes in a single case of florid follicular hyperplasia, raising the possibility that this case was an evolving malignancy. Despite frequent CT45 expression, only 1 of 67 Hodgkin lymphoma patients had detectable anti-CT45 antibodies in the serum, suggesting that the immune response to CT45 may be suppressed. In conclusion, classical Hodgkin lymphoma has the highest frequency of CT45 expression among all malignancies tested to date, the frequency of CT45 expression in DLBCL is similar to that seen in epithelial cancers, and low-grade non-Hodgkin B-cell lymphomas do not express CT45. PMID:20133697

Chen, Yao-Tseng; Chadburn, Amy; Lee, Peishan; Hsu, Melinda; Ritter, Erika; Chiu, April; Gnjatic, Sacha; Pfreundschuh, Michael; Knowles, Daniel M; Old, Lloyd J



Therapy-related classical Hodgkin lymphoma after a primary haematological malignancy: a report on 13 cases.  


The risk of developing Hodgkin lymphoma (HL) is increased in immunodeficiencies or during the treatment of some autoimmune diseases. The development of new therapeutic agents has highlighted the risk of unusual lymphoid proliferations, particularly classical HL (cHL). We report the clinicopathological findings of 13 cHL arising in patients treated for a primary haematological malignancy. Eight patients had received an immunomodulator, protein tyrosine-kinase inhibitor or monoclonal antibody, which may have contributed to the cHL development. Most patients had disseminated disease with poor prognostic factors at cHL diagnosis. Despite the initial presentation, good outcomes were achieved with standard cHL chemotherapy. PMID:22734472

Cheminant, Morgane; Galicier, Lionel; Brière, Josette; Boutboul, David; Micléa, Jean-Michel; Venon, Marie-Dominique; Robin, Marie; Thieblemont, Catherine; Brice, Pauline



Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma  

PubMed Central

An association between classical Hodgkin lymphoma (cHL) and mycosis fungoides (MF) or lymphomatoid papulosis (LyP) has been reported in the literature. However, there can be considerable morphologic and immunophenotypic overlap between cHL and nodal involvement by CD30-positive T-cell lymphoproliferative disorders (T-LPD). To examine this potential association, biopsies from patients with a prior history of MF or primary cutaneous CD30-positive T-LPD and lymph node biopsies reported as either CD30-positive T-cell lymphoma (TCL) with Hodgkin-like cells or cHL were retrieved from the authors’ institution. Of 11 cases identified, 10 were considered CD30-positive TCL with Hodgkin-like cells, while one was confirmed as cHL upon review. Five cases originally diagnosed as cHL were revised as CD30-positive TCL. Cases of CD30-positive TCL with Hodgkin-like cells showed a male predominance (M:F, 4:1) with a median age of 53 years (range 44-72 years). Nearly all patients (9/10) initially presented with skin lesions. In 7/10 patients the draining lymph node was involved, whereas in 3 cases this could not be confirmed. Tumor cells morphologically resembled Hodgkin/Reed-Sternberg (HRS) cells; they were uniformly strongly positive for CD30 and CD15 was expressed in 9/10 (90%) of cases. A T-cell derivation was confirmed by T-cell antigen expression (7/10) and clonal rearrangement of T-cell receptor genes (9/10). In three cases a common T-cell clone was identified in skin and lymph node. B-cell markers (CD20/PAX5) were consistently negative. In one case the diagnosis of cHL followed by LyP was confirmed, with HRS-cells expressing PAX5, CD30 and CD15. In situ hybridization studies for EBV were negative. We show that cHL is less often associated with MF and primary cutaneous CD30-positive T-cell LPD than previously thought, and that the co-expression of CD30 and CD15 in these T-cell lymphomas may lead to a mistaken diagnosis of cHL.

Eberle, Franziska C.; Song, Joo Y.; Xi, Liqiang; Raffeld, Mark; Harris, Nancy Lee; Wilson, Wyndham H.; Pittaluga, Stefania; Jaffe, Elaine S.



Rare occurrence of classical Hodgkin's disease as a T cell lymphoma.  


Recent work identified Hodgkin and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease (cHD) as clonal progeny of mature B cells. Therefore, it is generally assumed that cHD homogenously represents a B cell lymphoma. In a subset of cHD, however, H/RS cells expressing T cell-associated proteins may be candidates for alternative lineage derivation. Single H/RS cells with cytotoxic T cell phenotype were micromanipulated from three cases of cHD and analyzed by single cell polymerase chain reaction for immunoglobulin heavy (IgH) and light chain (IgL) gene rearrangements, T cell receptor (TCR)-beta gene rearrangements, and germline configuration of the IgH and TCR-beta loci. H/RS cells from two cases of cHD harbored clonal, somatically mutated Ig gene rearrangements, whereas TCR-beta loci were in germline configuration. In contrast, H/RS cells from an additional case harbored clonal TCR-beta variable/diversity/joining (VDJ) and DJ gene rearrangements, whereas the IgH locus was in germline configuration on both alleles. Thus, in two cases of cHD with H/RS cells expressing cytotoxic T cell molecules, the tumor cells are derived from mature B cells that aberrantly express T cell markers. In a third case, however, H/RS cells were derived from a T cell, demonstrating that cHD can also occur as a T cell lymphoma. PMID:10637283

Müschen, M; Rajewsky, K; Bräuninger, A; Baur, A S; Oudejans, J J; Roers, A; Hansmann, M L; Küppers, R



Hodgkin’s Lymphoma  

Microsoft Academic Search

\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a An estimated 8,490 new cases of Hodgkin’s lymphoma were diagnosed in the USA in 2010.\\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Reed–Sternberg cells are the malignant cells in classical Hodgkin’s lymphoma (CD15+, CD30+, and CD45?). In nodular lymphocyte-predominant\\u000a Hodgkin’s lymphoma (NLPHL), these cells express B-cell markers (CD20+, CD79a+, and CD45+) and are CD15? and CD30?.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Common presentation is an asymptomatic lymph node enlargement

Maryse Bernard; Richard W. Tsang


Classical Hodgkin lymphoma is characterized by recurrent copy number gains of the short arm of chromosome 2  

Microsoft Academic Search

Hodgkin- and Reed-Sternberg (HRS) cells microdissected from 41 classical Hodgkin lymphomas (cHL) of 40 patients compris- ing 8 lymphocyte-rich (cHL-LR), 16 nodu- lar sclerosis (cHL-NS), 15 mixed-cellular- ity (cHL-MC), and 2 lymphocyte-depletion (cHL-LD) subtypes were analyzed by comparative genomic hybridization for recurrently imbalanced chromosomal subregions. Chromosomal gains most fre- quently involved chromosome 2p (54%), 12q (37%), 17p (27%), 9p and

Stefan Joos; Christiane K. Menz; Gunnar Wrobel; Reiner Siebert; Stefan Gesk; Sibylle Ohl; Gunhild Mechtersheimer; Lorenz Trumper; Peter Moller; Peter Lichter; Thomas F. E. Barth



Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells.  


CD4(+) T-helper cells (THs) dominate the classical Hodgkin lymphoma (CHL) microenvironment, but their role is poorly understood. Advances in flow cytometry and immunohistochemistry permit more detailed investigation of this aspect of CHL pathophysiology. To address the hypothesis that the TH-infiltrate, rather than being TH2-enriched, senescent and hypofunctional, is TH1 and activation marker-rich, cytokine-secretory and proliferative, we applied comprehensive flow cytometric immunophenotyping and functional assays of cytokine secretion/proliferation to TH cells from 18 CHL-derived single-cell suspensions (SCSs) compared to reactive lymph nodes (RLNs). CHL-derived TH cells express TH1-associated CXCR3/CCR5 and TNF?/IFN?/interleukin-2 (IL-2) and less TH2-associated CCR3/CCR4, with no IL-4/IL-13. They lack exhaustion-/suppression-associated PD1, CD57 and terminally differentiated effector memory cells, with more central memory cells, activation-associated partners of Hodgkin Reed Sternberg (HRS) cell-expressed CD30/OX40-L/ICOS-L, and other activation markers. TH cell lines established from CHL and RLN-derived SCSs remain cytokine-secretory. We confirmed and extended these studies using tissue microarray immunohistochemistry (TMA-IHC) from a large CHL tissue bank (n = 122) and demonstrate TH1-associated TBET is abundant in CHL, and TH2-associated CMAF/GATA3 and exhaustion-associated PD1 expressed at significantly lower levels. These molecular insights into the CHL-associated TH offer potential diagnostic, prognostic and pharmacologically modifiable therapeutic targets and do not support the established view of a TH2-enriched, senescent/exhausted, hypofunctional, hypoproliferative infiltrate. PMID:24004665

Greaves, Paul; Clear, Andrew; Owen, Andrew; Iqbal, Sameena; Lee, Abigail; Matthews, Janet; Wilson, Andrew; Calaminici, Maria; Gribben, John G



MicroRNA signatures and treatment response in patients with advanced classical Hodgkin lymphoma.  


Although specific microRNA (miRNA) signatures in classical Hodgkin lymphoma (cHL) have been proposed, their relationship with clinical outcome remains unclear. Despite treatment advances, a substantial subset of patients with advanced cHL are refractory to standard therapies based on adriamycin and its variants. Global miRNA expression data of 29 advanced cHL patients and five cHL-derived cell lines were used to identify profiles from Hodgkin-Reed-Sternberg (HRS) cells and their non-tumoural microenvironment. A cHL-miRNA signature was identified with 234 miRNAs differentially expressed. A subset of these miRNAs was associated with outcome and selected for study in an independent set of 168 cHL samples using quantitative reverse transcription polymerase chain reaction. Multivariate Cox regression analyses including cross-validation with failure-free survival (FFS) as clinical endpoint revealed a miRNA signature with MIR21, MIR30E, MIR30D and MIR92B* that identified two risk-groups with significant differences in 5-year FFS (81% vs. 35.7%; P < 0.001). Additionally, functional silencing of MIR21 and MIR30D in L428 cells showed increased sensitivity to doxorubicin-induced apoptosis, pointing towards abnormalities of mitochondrial intrinsic and TP53-CDKN1A pathways as related to miRNA deregulation in cHL. These results suggest that clinical outcome in cHL is associated with a specific miRNA signature. Moreover, functional analyses suggest a role for MIR21 and MIR30D in cHL pathogenesis and therapeutic resistance. PMID:23725219

Sánchez-Espiridión, Beatriz; Martín-Moreno, Ana M; Montalbán, Carlos; Figueroa, Vianihuini; Vega, Francisco; Younes, Anas; Medeiros, L Jeffrey; Alvés, Francisco J; Canales, Miguel; Estévez, Mónica; Menarguez, Javier; Sabín, Pilar; Ruiz-Marcellán, María C; Lopez, Andrés; Sánchez-Godoy, Pedro; Burgos, Fernando; Santonja, Carlos; López, José L; Piris, Miguel A; Garcia, Juan F



Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases.  


Iatrogenic immunodeficiency-associated lymphoproliferative disorders are rare. A small subset of these lesions resembles classical Hodgkin lymphoma (CHL), but there are few data in the literature about these lesions. We describe 10 patients with autoimmune diseases treated with immunomodulator therapeutic agents who developed CHL. The autoimmune diseases included rheumatoid arthritis (n=5), systemic lupus erythematosus (n=2), dermatomyositis (n=1), autoimmune hepatitis (n=1), and Crohn disease (n=1), and the immunomodulatory therapies were methotrexate, azathioprine, tumor necrosis factor-? inhibitors, and thalidomide alone or in various combinations. The study group included 9 women and 1 man with a median age of 50 years (range, 25 to 77 y). The histologic features supported CHL in all cases with Reed-Sternberg (RS) and Hodgkin (H) cells in an inflammatory cell background, although the neoplasm could only be subclassified in 3 patients: 2 nodular sclerosis and 1 mixed cellularity. Immunohistochemical analysis supported the diagnosis of CHL. In all cases the RS-H cells were CD30. Nine of 10 cases were CD15, whereas CD20 was expressed variably in 4/10 cases. CD45/LCA was negative in 8 cases assessed. In situ hybridization for Epstein-Barr virus-encoded RNA was positive in the RS-H cells in 8/10 cases. The microenvironment of these lesions depicted a predominance of T-regulatory cells and M2 histiocytes. Clinical follow-up data were available for 7 patients, with a median posttreatment period of 27 months (range, 12 mo to 7 y). In all 7 patients immunomodulatory drug therapy was discontinued, and chemotherapy for CHL was administered; 2 patients also received local radiation. All 7 patients achieved complete remission and are alive. We conclude that iatrogenic immunodeficiency-associated CHL is highly associated with Epstein-Barr virus infection, and patients usually have a good outcome after discontinuation of immunomodulatory agents and chemotherapy for CHL. PMID:23774171

Loo, Eric Y; Medeiros, L Jeffrey; Aladily, Tariq N; Hoehn, Daniela; Kanagal-Shamanna, Rashmi; Young, Ken H; Lin, Pei; Bueso-Ramos, Carlos E; Manning, John T; Patel, Keyur; Thomazy, Vilmos; Brynes, Russell K; Goswami, Maitrayee; Fayad, Luis E; Miranda, Roberto N



Minimal change nephrotic syndrome and classical Hodgkin's lymphoma: Report of 21 cases and review of the literature  

Microsoft Academic Search

Minimal change nephrotic syndrome (MCNS) is described as a paraneoplastic manifestation of classical Hodgkin's lymphoma (cHL). We reassessed the pathophysiological and clinical significance of this association. A retrospective study was performed to evaluate a cohort of adult patients who developed MCNS and cHL. Twenty-one patients recruited in 15 French centers were analyzed. cHL was associated with inflammatory and general symptoms

V Audard; F Larousserie; P Grimbert; M Abtahi; J-J Sotto; A Delmer; F Boue; D Nochy; N Brousse; R Delarue; P Remy; P Ronco; D Sahali; P Lang; O Hermine



Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma  

PubMed Central

In the present study, we evaluated the efficacy and safety of rituximab in combination with standard doxorubicin, bleomycin, vinblastine, and dacarbazine (RABVD) in patients with classical Hodgkin lymphoma (cHL). In this phase 2 study, patients with chemotherapy-naive, advanced-stage cHL were treated with rituximab 375 mg/m2 weekly for 6 weeks and standard ABVD for 6 cycles. The primary outcome was event-free survival (EFS) at 5 years. Eighty-five patients were enrolled, of whom 78 were eligible. With a median follow-up duration of 68 months (range, 26-110), and based on an intent-to-treat analysis, the 5-year EFS and overall survival rates were 83% and 96%, respectively. The 5-year EFS for patients with stage III/IV cHLwas 82%. Furthermore, the 5-year EFS for patients with an International Prognostic Score of 0-2 was 88% and for those with a score of > 2, it was 73%. The most frequent treatment-related grade 3 or 4 adverse events were neutropenia (23%), fatigue (9%), and nausea (8%). Our results demonstrate that the addition of rituximab to ABVD is safe and has a promising clinical activity in patients with advanced-stage cHL. These data are currently being confirmed in a multicenter randomized trial. This trial has been completed and is registered with as NCT00504504.

Oki, Yasuhiro; McLaughlin, Peter; Copeland, Amanda R.; Goy, Andre; Pro, Barbara; Feng, Lei; Yuan, Ying; Chuang, Hubert H.; Macapinlac, Homer A.; Hagemeister, Fredrick; Romaguera, Jorge; Samaniego, Felipe; Fanale, Michelle A.; Dabaja, Bouthaina Shbib; Rodriguez, Maria A.; Dang, Nam; Kwak, Larry W.; Neelapu, Sattva S.; Fayad, Luis E.



Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma.  


In the present study, we evaluated the efficacy and safety of rituximab in combination with standard doxorubicin, bleomycin, vinblastine, and dacarbazine (RABVD) in patients with classical Hodgkin lymphoma (cHL). In this phase 2 study, patients with chemotherapy-naive, advanced-stage cHL were treated with rituximab 375 mg/m(2) weekly for 6 weeks and standard ABVD for 6 cycles. The primary outcome was event-free survival (EFS) at 5 years. Eighty-five patients were enrolled, of whom 78 were eligible. With a median follow-up duration of 68 months (range, 26-110), and based on an intent-to-treat analysis, the 5-year EFS and overall survival rates were 83% and 96%, respectively. The 5-year EFS for patients with stage III/IV cHL was 82%. Furthermore, the 5-year EFS for patients with an International Prognostic Score of 0-2 was 88% and for those with a score of > 2, it was 73%. The most frequent treatment-related grade 3 or 4 adverse events were neutropenia (23%), fatigue (9%), and nausea (8%). Our results demonstrate that the addition of rituximab to ABVD is safe and has a promising clinical activity in patients with advanced-stage cHL. These data are currently being confirmed in a multicenter randomized trial. PMID:22371887

Younes, Anas; Oki, Yasuhiro; McLaughlin, Peter; Copeland, Amanda R; Goy, Andre; Pro, Barbara; Feng, Lei; Yuan, Ying; Chuang, Hubert H; Macapinlac, Homer A; Hagemeister, Fredrick; Romaguera, Jorge; Samaniego, Felipe; Fanale, Michelle A; Dabaja, Bouthaina Shbib; Rodriguez, Maria A; Dang, Nam; Kwak, Larry W; Neelapu, Sattva S; Fayad, Luis E



Galectin-1 serum levels reflect tumor burden and adverse clinical features in classical Hodgkin lymphoma.  


Galectin-1 (Gal1) is a member of a highly conserved family of carbohydrate-binding proteins. It modulates innate and adaptive immune responses and fosters tumor-immune escape. Hodgkin lymphoma (HL) Reed-Sternberg cells overexpress and secrete Gal1, which selectively kills T helper (Th)1 and Th17 cells and cytotoxic T cells and promotes the immunosuppressive Th2/regulatory T-cell-predominant HL microenvironment. We developed a sandwich enzyme-linked immunosorbent assay and assessed serum Gal1 levels in 293 newly diagnosed, previously untreated patients with classical HL (cHL) enrolled in 3 risk-adapted clinical trials. Serum Gal1 levels were significantly higher in patients with cHL than in normal controls (P < .0001). Gal1 serum levels also increased with Ann Arbor stage (P = .012), areas of nodal involvement (P < .0001), and the International Prognostic Score (2-7, P = .019). We conclude that Gal1 serum levels are significantly associated with tumor burden and related clinical features in newly diagnosed cHL patients. PMID:23444403

Ouyang, Jing; Plütschow, Annette; Pogge von Strandmann, Elke; Reiners, Katrin S; Ponader, Sabine; Rabinovich, Gabriel A; Neuberg, Donna; Engert, Andreas; Shipp, Margaret A



Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations.  


Epstein-Barr virus (EBV) is detected in the tumor cells of some but not all Hodgkin lymphoma (HL) patients, and evidence indicates that EBV-positive and -negative HL are distinct entities. Racial/ethnic variation in EBV-positive HL in international comparisons suggests etiologic roles for environmental and genetic factors, but these studies used clinical series and evaluated EBV presence by differing protocols. Therefore, we evaluated EBV presence in the tumors of a large (n = 1,032), racially and sociodemographically diverse series of California incident classical HL cases with uniform pathology re-review and EBV detection methods. Tumor EBV-positivity was associated with Hispanic and Asian/Pacific Islander (API) but not black race/ethnicity, irrespective of demographic and clinical factors. Complex race-specific associations were observed between EBV-positive HL and age, sex, histology, stage, neighborhood socioeconomic status (SES), and birth place. In Hispanics, EBV-positive HL was associated not only with young and older age, male sex, and mixed cellularity histology, but also with foreign birth and lower SES in females, suggesting immune function responses to correlates of early childhood experience and later environmental exposures, respectively, as well as of pregnancy. For APIs, a lack of association with birth place may reflect the higher SES of API than Hispanic immigrants. In blacks, EBV-positive HL was associated with later-stage disease, consistent with racial/ethnic variation in certain cytokine polymorphisms. The racial/ethnic variation in our findings suggests that EBV-positive HL results from an intricate interplay of early- and later-life environmental, hormonal, and genetic factors leading to depressed immune function and poorly controlled EBV infection. PMID:18646185

Glaser, Sally L; Gulley, Margaret L; Clarke, Christina A; Keegan, Theresa H; Chang, Ellen T; Shema, Sarah J; Craig, Fiona E; Digiuseppe, Joseph A; Dorfman, Ronald F; Mann, Risa B; Anton-Culver, Hoda; Ambinder, Richard F



Insulin-like growth factor 1 receptor is a prognostic factor in classical Hodgkin lymphoma.  


The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p =?.029 and PFS 77%, p =?.047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines. PMID:24489919

Liang, Zheng; Diepstra, Arjan; Xu, Chuanhui; van Imhoff, Gustaaf; Plattel, Wouter; Van Den Berg, Anke; Visser, Lydia



Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes  

PubMed Central

It is currently considered that idiopathic minimal change nephrotic syndrome (I-MCNS) is an immune-mediated glomerular disease. Its association with classical Hodgkin lymphoma (cHL-MCNS) suggests a molecular link between these two diseases, which remains to be elucidated. We analyzed the expression of c-mip (cmaf inducing protein) in lymphomatous tissues and kidney biopsies of patients with cHL-MCNS (n=8) and in lymphomatous tissues of isolated cHL (n=9). Because c-mip affects the regulatory loop involving Fyn, we investigated possible structural defects in this signaling pathway, using laser capture microdissection, RT-PCR and Western-blotting. We found that c-mip was selectively expressed in Hodgkin and Reed-Sternberg (HRS) cells and podocytes of patients with cHL-MCNS but is undetectable in patients with isolated cHL. We demonstrated that c-mip was specifically involved in the negative regulation of early proximal signaling through its interaction with PAG and Fyn. We showed that the upregulation of c-mip in cHL-MCNS was associated with a possible Fyn defect in HRS cells and podocytes, while Fyn was normally expressed in isolated cHL and normal podocytes. Moreover, we showed that c-mip was upregulated in Fyn-deficient podocytes. C-mip may be a useful marker of cHL-MCNS and its induction reflects the dysregulation of proximal signaling.

Audard, Vincent; Zhang, Shao-Yu; Copie-Bergman, Christiane; Rucker-Martin, Catherine; Ory, Virginie; Candelier, Marina; Baia, Maryse; Lang, Philippe; Pawlak, Andre; Sahali, Djillali



Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency  

PubMed Central

Cutaneous Hodgkin lymphoma is a rare condition. Specific neoplastic involvement can be primary (confined to the skin) or secondary to systemic involvement (metastatic). Cutaneous involvement by HL usually occurs late in the course and is associated with poor prognosis; however in some cases it can exhibit indolent behavior. Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome. We describe a case of 46-year-old white male patient presented with rash and lymphadenopathy which led to the diagnosis of stage IVE mixed cellularity classical Hodgkin lymphoma with skin involvement. His disease was refractory to multiple lines of chemotherapy including (1) AVD (doxorubicin/bleomycin/dacarbazine), (2) brentuximab, and (3) bendamustine, he later achieved complete remission with (4) GCD (gemcitabine/carboplatin/dexamethasone) salvage regimen. Bleomycin was not given secondary to poor pulmonary function tests. His treatment was complicated after AVD with multiple pneumothoraces which unmasked the diagnosis of ZZ phenotype alpha-1 antitrypsin (ATT) deficiency. Simultaneous existence of Hodgkin lymphoma and ATT is rarely reported.

Kraus, Teresa; Cherry, Mohamad



Why Chinese People Play Western Classical Music: Transcultural Roots of Music Philosophy  

ERIC Educational Resources Information Center

This paper addresses the complex relationship between Confucian values and music education in East Asia, particularly its history in China. How does one account for the present "cultural fever" of Western classical music that has infected more than 100 million Chinese practitioners? It is proposed that Western classical music finds transcultural…

Huang, Hao



Sphingosine-1-Phosphate Receptor 1 in Classical Hodgkin Lymphoma: Assessment of Expression and Role in Cell Migration  

PubMed Central

Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed Sternberg cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology, the factors which regulate the spread of lymphoma cells in CHL are poorly understood. Sphingosine-1-Phosphate (S1P), a bioactive sphingolipid present at high concentrations in plasma and lymphatic fluid, is known to play a critical role in regulating lymphocyte trafficking mainly through S1PR1. In this study, we explore the role of the S1P-S1PR1 axis in Hodgkin lymphoma cell migration and the expression of S1PR1 in CHL cell lines and clinical cases. We found that S1PR1 is present in the KM-H2 and SUP-HD1 Hodgkin lymphoma cell lines at the mRNA and protein level. In addition, functionally, S1P potently stimulated migration of both cell lines. S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116 and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2 specific antagonist, JTE013. We also determined that S1PR1 induced migration in the KM-H2 and SUP-HD1 cells via the heterotrimeric G protein Gi and the phosphatidylinositol-3-kinase (PI3K) pathway. Immunohistochemical assessment of tissue from CHL samples revealed that a subset of cases (7/57; 12%) show strong, membranous staining for S1PR1 in Hodgkin-Reed Sternberg cells. Altogether our data indicate that S1PR1 is a functional receptor on Hodgkin-Reed Sternberg cells which governs tumor cell migration and is expressed in a subset of CHL cases. Given the availability of S1PR1 antagonists, some of which are used clinically for modulation of the immune system, these results suggest that S1PR1 could be a future therapeutic target in the treatment of those cases of S1PR1-positive, refractory/recurrent CHL.

Kluk, Michael J.; Ryan, Kieran; Wang, Bonnie; Zhang, Guoqi; Rodig, Scott J.; Sanchez, Teresa



Paraneoplastic granulomatous vitritis and retinitis as a presentation of recurrent classical Hodgkin's lymphoma.  


We describe a unique case of a patient with an established diagnosis of Hodgkin's lymphoma in clinical remission who later presented with apparent vitreous inflammation. A vitreous biopsy (including fortuitously some peripheral retinal fragments) exhibited granulomatous inflammation. Since the latter can be a paraneoplastic phenomenon of active Hodgkin's lymphoma in distant organ sites, the haematologists were alerted to the possibility of recurrent lymphoma, despite the patient having no clinical symptoms. Repeat body imaging showed enlarged mediastinal lymph nodes, biopsy of which confirmed recurrent Hodgkin's lymphoma. The patient responded well to systemic chemotherapy with resolution of the visual symptoms. This case report illustrates the importance of vitreous biopsy in this clinical setting and how to interpret the significance of granulomas in this context, and outlines a unique vitreo-retinal paraneoplastic granulomatous presentation in the setting of recurrent Hodgkin's lymphoma and how this diagnosis triggered a prompt review of the patient who had no constitutional symptoms, with hopefully a favourable impact on prognosis given the early recurrent disease detection. PMID:20076991

Mudhar, Hardeep Singh; Fernando, Malee; Sheard, Richard; Rennie, Ian



HLA-A*02:07 Is a Protective Allele for EBV Negative and a Susceptibility Allele for EBV Positive Classical Hodgkin Lymphoma in China  

PubMed Central

HLA-A2 protects from EBV+ classical Hodgkin lymphoma (cHL) in Western Europe, but it is unknown whether this protective effect also exists in the Chinese population. We investigated the association of HLA-A2 and specific common and well documented HLA-A2 subtypes with EBV stratified cHL patients (n?=?161) from the northern part of China. Quantitative-PCR and sequence-based subtyping was performed to identify HLA-A2 positive samples and their subtypes. 67 (42%) of the cHL patients were EBV+. There were no significant differences in percentages of HLA-A2 positivity between cHL and controls (65% vs 66%) and between EBV+ and EBV? cHL patients (70% vs 61%). The frequency distribution of HLA-A2 subtypes was significantly different between EBV stratified cHL subgroups and controls. This difference was most striking for the HLA-A*02:07 type with a frequency of 38% in EBV+ cHL, 8% in EBV? cHL and 20% in controls. Significant differences were also observed for the HLA-A*02:07, HLA-A2 (non-02:07) and the A2-negative typings between EBV+ cHL vs controls (p?=?0.028), EBV? cHL vs controls (p?=?0.045) and EBV+ vs EBV? cHL cases (p?=?2×10?5). In conclusion, HLA-A*02:07 is a predisposing allele for EBV+ cHL and a protective allele for EBV? cHL in the northern Chinese population.

Huang, Xin; Hepkema, Bouke; Nolte, Ilja; Kushekhar, Kushi; Jongsma, Theo; Veenstra, Rianne; Poppema, Sibrand; Gao, Zifen; Visser, Lydia; Diepstra, Arjan; van den Berg, Anke



Composite diffuse large B-cell lymphoma and classical Hodgkin's lymphoma of the stomach: case report and literature review.  


The combination of classical Hodgkin's lymphoma (cHL) and non-Hodgkin lymphoma coexisting in the same patient is not common, especially in one extranodal location. Here we present a rare case of composite diffuse large B-cell lymphoma (DLBCL) and cHL occurring simultaneously in the stomach of a 53-year-old female who presented with upper abdominal discomfort and gas pain. Surgery was performed and the disease was diagnosed pathologically as composite lymphoma of DLBCL and cHL using hematoxylin-eosin and immunohistochemical staining. Epstein-Barr virus (EBV) infection was not detected by in situ hybridization for EBV-encoded RNA or immunohistochemistry for EBV latent membrane protein-1. Polymerase chain reaction analysis from the two distinct components of the tumor demonstrated clonal immunoglobulin ? light chain gene rearrangements. The patient died approximately 11 mo after diagnosis in spite of receiving eight courses of the CHOP and two courses of the rituximab-CHOP (RCHOP) chemotherapy regimen. This case report showed that the two distinct components, DLBCL and cHL, appeared to originate from the same clonal progenitor cell, and that EBV infection was not essential for transformation during the course of tumorigenesis. PMID:24115832

Wang, Hong-Wei; Yang, Wen; Wang, Lin; Lu, Yun-Long; Lu, Jiang-Yang



Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration.  


Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed-Sternberg (HRS) cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology, the factors that regulate the spread of lymphoma cells in CHL are poorly understood. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid present at high concentrations in the plasma and lymphatic fluid, is known to have a critical role in regulating lymphocyte trafficking mainly through sphingosine-1-phosphate receptor 1 (S1PR1). In this study, we explore the role of the S1P-S1PR1 axis in Hodgkin lymphoma cell migration and the expression of S1PR1 in CHL cell lines and clinical cases. We found that S1PR1 is present in the KM-H2 and SUP-HD1 Hodgkin lymphoma cell lines at the mRNA and protein level. In addition, functionally, S1P potently stimulated migration of both cell lines. S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116, and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2-specific antagonist, JTE013. We also determined that S1PR1 induced migration in the KM-H2 and SUP-HD1 cells via the heterotrimeric G-protein Gi and the phosphatidylinositol-3-kinase pathway. Immunohistochemical assessment of the tissue from CHL samples revealed that a subset of cases (7/57; 12%) show strong, membranous staining for S1PR1 in HRS cells. Altogether, our data indicate that S1PR1 is a functional receptor on HRS cells, which governs tumor cell migration and is expressed in a subset of CHL cases. Given the availability of S1PR1 antagonists, some of which are used clinically for modulation of the immune system, these results suggest that S1PR1 could be a future therapeutic target in the treatment of those cases of S1PR1-positive, refractory/recurrent CHL. PMID:23419711

Kluk, Michael J; Ryan, Kieran P; Wang, Bonnie; Zhang, Guoqi; Rodig, Scott J; Sanchez, Teresa



Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"  

ERIC Educational Resources Information Center

This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it is impossible and undesirable…

Tan, Sor-Hoon



Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial  

PubMed Central

Increased tumor-associated macrophages (TAMs) are reported to be associated with poor prognosis in classic Hodgkin lymphoma (CHL). We investigated the prognostic significance of TAMs in the E2496 Intergroup trial, a multicenter phase 3 randomized controlled trial comparing ABVD and Stanford V chemotherapy in locally extensive and advanced stage CHL. Tissue microarrays were constructed from formalin-fixed, paraffin-embedded tumor tissue and included 287 patients. Patients were randomly assigned into training (n = 143) and validation (n = 144) cohorts. Immunohistochemistry for CD68 and CD163, and in situ hybridization for EBV-encoded RNA were performed. CD68 and CD163 IHC were analyzed by computer image analysis; optimum thresholds for overall survival (OS) were determined in the training cohort and tested in the independent validation cohort. Increased CD68 and CD163 expression was significantly associated with inferior failure-free survival and OS in the validation cohort. Increased CD68 and CD163 expression was associated with increased age, EBV-encoded RNA positivity, and mixed cellularity subtype of CHL. Multivariate analysis in the validation cohort showed increased CD68 or CD163 expression to be significant independent predictors of inferior failure-free survival and OS. We demonstrate the prognostic significance of TAMs in locally extensive and advanced-stage CHL in a multicenter phase 3 randomized controlled clinical trial.

Tan, King L.; Scott, David W.; Hong, Fangxin; Kahl, Brad S.; Fisher, Richard I.; Bartlett, Nancy L.; Advani, Ranjana H.; Buckstein, Rena; Rimsza, Lisa M.; Connors, Joseph M.; Steidl, Christian; Gordon, Leo I.; Horning, Sandra J.



Mutations in a gene encoding a midbody kelch protein in familial and sporadic classical Hodgkin lymphoma lead to binucleated cells  

PubMed Central

Classical Hodgkin lymphoma (cHL) is a malignancy of B-cell origin in which the neoplastic cells, known as “Reed-Sternberg” (RS) cells, are characteristically binucleated. Here we describe a family where multiple individuals developing cHL have inherited a reciprocal translocation between chromosomes 2 and 3. The translocation disrupts KLHDC8B, an uncharacterized gene from a region (3p21.31) previously implicated in lymphoma and related malignancies, resulting in its loss of expression. We tested KLHDC8B as a candidate gene for cHL and found that a 5?-UTR polymorphism responsible for decreasing its translational expression is associated with cHL in probands from other families with cHL and segregates with disease in those pedigrees. In one of three informative sporadic cases of cHL, we detected loss of heterozygosity (LOH) for KLHDC8B in RS cells, but not reactive T lymphocytes, purified from a malignant lymph node. KLHDC8B encodes a protein predicted to contain seven kelch repeat domains. KLHDC8B is expressed during mitosis, where it localizes to the midbody structure connecting cells about to separate during cytokinesis, and it is degraded after cell division. Depletion of KLHDC8B through RNA interference leads to an increase in binucleated cells, implicating its reduced expression in the formation of cHL's signature RS cell.

Salipante, Stephen J.; Mealiffe, Matthew E.; Wechsler, Jeremy; Krem, Maxwell M.; Liu, Yajuan; Namkoong, Shinae; Bhagat, Govind; Kirchhoff, Tomas; Offit, Kenneth; Lynch, Henry; Wiernik, Peter H.; Roshal, Mikhail; McMaster, Mary Lou; Tucker, Margaret; Fromm, Jonathan R.; Goldin, Lynn R.; Horwitz, Marshall S.



Concurrent malignant melanoma and cutaneous involvement by classical hodgkin lymphoma (CHL) in a 63 year-old man  

PubMed Central

Abstract Classical Hodgkin lymphoma (CHL) is a lymphoproliferative disorder that has a bimodal age distribution, affecting young and elderly individuals, and is curable in more than 90% of patients. Here we report the coexistence of cutaneous CHL and malignant melanoma as the presentation of papules and a plaque, in an individual with remote history of systemic CHL. One of the biopsies showed a mononuclear cell infiltrate with Reed-Sternberg (RS) like cells that were positive for CD30 and CD15, but negative for CD45. A second concurrent biopsy showed an atypical melanocytic proliferation with significant pagetoid spreading and diffuse Melan-A staining. Based on morphology alone, it is almost impossible to distinguish CHL from other primary cutaneous lymphoproliferative disorders, such as CD30+ lymphoproliferative disorder (lymphomatoid papulosis (LyP) and primary cutaneous anaplastic large-cell lymphoma), or even tumor stage mycosis fungoides when the epidermotropism is minimal. Additionally, bizarre melanocytic cells can also appear similar to RS cells. Our case illustrates the first case report of malignant melanoma and CHL in a patient presenting simultaneously. Virtual slides The virtual slide(s) for this article can be found here:



Classical Hodgkin's lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant  

PubMed Central

The Hodgkin’s Lymphoma Committee of the Lymphoma Study Association (LYSA) gathered in 2012 to prepare guidelines on the management of transplant-eligible patients with relapsing or refractory Hodgkin’s lymphoma. The working group is made up of a multidisciplinary panel of experts with a significant background in Hodgkin’s lymphoma. Each member of the panel of experts provided an interpretation of the evidence and a systematic approach to obtain consensus was used. Grades of recommendation were not required since levels of evidence are mainly based on phase II trials or standard practice. Data arising from randomized trials are emphasized. The final version was endorsed by the scientific council of the LYSA. The expert panel recommends a risk-adapted strategy (conventional treatment, or single/double transplantation and/or radiotherapy) based on three risk factors at progression (primary refractory disease, remission duration < 1 year, stage III/IV), and an early evaluation of salvage chemosensitivity, including 18fluorodeoxy glucose-positron emission tomography interpreted according to the Deauville scoring system. Most relapsed or refractory Hodgkin’s lymphoma patients chemosensitive to salvage should receive high-dose therapy and autologous stem-cell transplantation as standard. Efforts should be made to increase the proportion of chemosensitive patients by alternating non-cross-resistant chemotherapy lines or exploring the role of novel drugs.

Van Den Neste, Eric; Casasnovas, Olivier; Andre, Marc; Touati, Mohamed; Senecal, Delphine; Edeline, Veronique; Stamatoullas, Aspasia; Fornecker, Luc; Deau, Benedicte; Gastinne, Thomas; Reman, Oumedaly; Gaillard, Isabelle; Borel, Cecile; Brice, Pauline; Ferme, Christophe



Expression of CCL28 by Reed-Sternberg Cells Defines a Major Subtype of Classical Hodgkin's Disease with Frequent Infiltration of Eosinophils and/or Plasma Cells  

PubMed Central

Classical Hodgkin’s disease (HD) is characterized by rare neoplastic Hodgkin and Reed-Sternberg (H-RS) cells within abundant reactive cellular backgrounds. In most cases, H-RS cells originate from the B-cell lineage, but their immunophenotypes are unusual. Here we newly found frequent expression of chemokine receptors CXCR6 and CCR10 and their respective ligands CXCL16 and CCL28 in HD-derived cell lines. CCR10 is known to be selectively expressed by plasma cells, whereas CCL28 attracts eosinophils via CCR3 and plasma cells via CCR10 and CCR3. Therefore, we examined their expression in HD tissues by immunohistochemistry. We found that H-RS cells in 15 of 19 cases were positive for CCL28. Among them, seven cases were also positive for CCR10, suggesting a potential autocrine effect. In situ hybridization confirmed the expression of CCL28 mRNA in H-RS cells. The CCL28 positivity in H-RS cells did not significantly correlate with that of LMP-1, CCL17, CCL22, or CCL11. However, it significantly correlated with the background accumulation of eosinophils, plasma cells, and CCR10+ cells. Thus, the production of CCL28 by H-RS cells may play a major role in tissue accumulation of eosinophils and/or plasma cells in classical HD. The frequent expression of CCR10 in H-RS cells themselves also supports their close relationship to plasma cells.

Hanamoto, Hitoshi; Nakayama, Takashi; Miyazato, Hajime; Takegawa, Sumio; Hieshima, Kunio; Tatsumi, Yoichi; Kanamaru, Akihisa; Yoshie, Osamu



Hodgkin lymphoma  


Lymphoma - Hodgkin; Hodgkin disease; Cancer - Hodgkin lymphoma ... The cause of Hodgkin lymphoma is not known. Hodgkin lymphoma is most common among people ages 15 to 35 and 50 to 70. Past infection ...


Peripheral blood CD4/CD19 cell ratio is an independent prognostic factor in classical Hodgkin lymphoma.  


Abstract Classical Hodgkin lymphoma (cHL) is characterized by the presence of tumoral cells in a rich background of T and B cells, macrophages and other inflammatory cells. The contribution of these non-tumoral cells to the pathogenesis of HL is still poorly understood. In our study we evaluated the prognostic significance of peripheral blood B, T and natural killer (NK) cells at diagnosis in 118 immunocompetent patients with cHL treated at our institution between January 2006 and December 2010. Fifty-four (46%) were male and 64 (54%) female. Median age at diagnosis was 33 years (range 15-82), and 71 patients (60%) presented an advanced stage (IIB-IV), 54 (46%) had bulky disease and 55 (47%) presented B symptoms. At the end of treatment, 94 patients (80%) had a complete response (CR) and 24 (20%) had a partial response. After a median follow-up of 54 months, 18 patients (15%) had relapsed. The variables that had a negative impact on progression-free survival (PFS) at univariate analysis were advanced stage, bone marrow involvement, International Prognostic Score (IPS) ? 3, positive interim positron emission tomography (int-PET), NK cells < 200/?L, CD19 cells < 85/?L, CD3/CD19 ratio ? 13 and CD4/CD19 ratio ? 10. At multivariate analysis, advanced stage, positive int-PET and CD4/CD19 ratio ? 10 were independent prognostic factors of PFS. New biological markers could be predictive of the response to treatment and survival in cHL. A CD4/CD19 ratio ? 10 seems to be associated with a worse outcome. PMID:24164533

Gaudio, Francesco; Perrone, Tommasina; Mestice, Anna; Curci, Paola; Giordano, Annamaria; Delia, Mario; Pastore, Domenico; Specchia, Giorgina



CD163 Expression Was Associated with Angiogenesis and Shortened Survival in Patients with Uniformly Treated Classical Hodgkin Lymphoma  

PubMed Central

Background Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Methods Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohistochemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel density (MVD). Results High CD163 expression (?35% of cellularity) correlated with VEGF expression (Pearson’s Chi-square test, P?=?0.008) and MVD (Spearman correlation coefficient 0.310, P<0.001). High CD163 expression was associated with inferior event-free survival (EFS, P?=?0.005) and overall survival (OS, P<0.001) in univariate analysis. In multivariate analysis, high CD163 expression was strongly associated with inferior EFS (P?=?0.043) and OS (P?=?0.008). Patients with high MVD had a lower OS than those with low MVD, but the difference was not significant (P?=?0.071, respectively). While high expression of CD68 was also associated with inferior EFS (P?=?0.007), it showed no correlation with VEGF or MVD. Conclusions Our data confirms that CD163 expression provides independent prognostic information in cHL. The correlation of CD163 with VEGF expression and MVD suggests the role of CD163-positive cells in tumor angiogenesis of cHL.

Koh, Young Wha; Park, Chan-Sik; Yoon, Dok Hyun; Suh, Cheolwon; Huh, Jooryung



Socioeconomic inequality in the use of rituximab therapy among non-Hodgkin lymphoma patients in Chinese public hospitals.  


Rituximab is a patient-paid effective monoclonal-antibody drug for non-Hodgkin lymphoma (NHL). Little is known in China, a country with unequal distribution of wealth and medical insurance systems, about the impact of socioeconomic status (SES) on selecting rituximab therapy in NHL patients. A total of 328 NHL inpatients in 2 public hospitals in Hangzhou were recruited and divided into 2 equal groups: with rituximab therapy and with no rituximab therapy group. Selection and frequency of rituximab therapy increased with duration of education and in urban citizens (P < .01). Officers and businessmen were more likely to use rituximab therapy compared with farmers (P < .01). Patients covered by Urban Employee Basic Medical Insurance were more likely to select rituximab therapy than those insured with Urban-Rural Residents Basic Medical Insurance (P < .01). There was an inequality in provision of rituximab therapy among Chinese NHL patients, and this was associated with differences in SES status. Effective measures are suggested to ameliorate the inequality issue. PMID:23162009

Yu-Wen, Huang; Mei-Bian, Zhang; Xiang, Xu; Xiao-Hua, Xu; Quan, Zhou; Le, Jian



A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin  

PubMed Central

At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials, the response rate and complete remission rate of this drug were 73% and 40%, respectively, for relapsed and refractory HL. Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab. Before the treatment with brentuximab, the patient underwent chemotherapy, radiotherapy, and autologous stem cell transplantation. However, the disease continued to progress, affecting multiple organs and prompting symptoms such as persistent fever. After the treatment with brentuximab, the patient's condition improved. Body temperature returned to normal after 4 days. Lung nodules were reduced in size and number after a single course of treatment, and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment, respectively. The entire treatment process progressed smoothly, though the patient experienced some symptoms due to chemotherapy, including peripheral neuritis of the limbs, irritating dry cough, and mild increase in aminotransferase. No serious adverse effects were observed. The current general condition of the patient is good; the continuous complete remission has amounted to 6 months.

Cao, Zhi-Gang; Zhou, Hong-Wei; Peng, Chao-Jin; Liu, Mo; Du, Yu; Yang, Qing-Ming



A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin.  


At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials, the response rate and complete remission rate of this drug were 73% and 40%, respectively, for relapsed and refractory HL. Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab. Before the treatment with brentuximab, the patient underwent chemotherapy, radiotherapy, and autologous stem cell transplantation. However, the disease continued to progress, affecting multiple organs and prompting symptoms such as persistent fever. After the treatment with brentuximab, the patient's condition improved. Body temperature returned to normal after 4 days. Lung nodules were reduced in size and number after a single course of treatment, and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment, respectively. The entire treatment process progressed smoothly, though the patient experienced some symptoms due to chemotherapy, including peripheral neuritis of the limbs, irritating dry cough, and mild increase in aminotransferase. No serious adverse effects were observed. The current general condition of the patient is good; the continuous complete remission has amounted to 6 months. PMID:23544448

Cao, Zhi-Gang; Zhou, Hong-Wei; Peng, Chao-Jin; Liu, Mo; Du, Yu; Yang, Qing-Ming



Nodular Lymphocyte Predominant Hodgkin's Lymphoma  

Microsoft Academic Search

Whereas it is estimated that 7800 new cases of Hodgkin’s lymphoma (HL) will be diagnosed in 2006, nodular lymphocyte predominant\\u000a Hodgkin lymphoma (NLPHL) will only account for 3–8% of newly diagnosed HL (1, 2). The majority of the incidence is accounted\\u000a for by the classical Hodgkin lymphoma (cHL) subtypes (nodular sclerosing, lymphocyte rich, lymphocyte depleted, and mixed\\u000a cellularity). There exists

Michelle A. Fanale; Anas Younes


Classical Hodgkin's lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant.  


The Hodgkin's Lymphoma Committee of the Lymphoma Study Association (LYSA) gathered in 2012 to prepare guidelines on the management of transplant-eligible patients with relapsing or refractory Hodgkin's lymphoma. The working group is made up of a multidisciplinary panel of experts with a significant background in Hodgkin's lymphoma. Each member of the panel of experts provided an interpretation of the evidence and a systematic approach to obtain consensus was used. Grades of recommendation were not required since levels of evidence are mainly based on phase II trials or standard practice. Data arising from randomized trials are emphasized. The final version was endorsed by the scientific council of the LYSA. The expert panel recommends a risk-adapted strategy (conventional treatment, or single/double transplantation and/or radiotherapy) based on three risk factors at progression (primary refractory disease, remission duration < 1 year, stage III/IV), and an early evaluation of salvage chemosensitivity, including (18)fluorodeoxy glucose-positron emission tomography interpreted according to the Deauville scoring system. Most relapsed or refractory Hodgkin's lymphoma patients chemosensitive to salvage should receive high-dose therapy and autologous stem-cell transplantation as standard. Efforts should be made to increase the proportion of chemosensitive patients by alternating non-cross-resistant chemotherapy lines or exploring the role of novel drugs. PMID:23904236

Van Den Neste, Eric; Casasnovas, Olivier; André, Marc; Touati, Mohamed; Senecal, Delphine; Edeline, Véronique; Stamatoullas, Aspasia; Fornecker, Luc; Deau, Bénédicte; Gastinne, Thomas; Reman, Oumédaly; Gaillard, Isabelle; Borel, Cécile; Brice, Pauline; Fermé, Christophe



Chinese herbs for memory disorders: a review and systematic analysis of classical herbal literature.  


Text mining and other literature-based investigations can assist in identifying natural products for experimental and clinical research. This article details a method for systematically analyzing data derived from the classical Chinese medical literature. We present the results of electronic searches of Zhong Hua Yi Dian ("Encyclopaedia of Traditional Chinese Medicine"), a CD of 1000 premodern (before 1950) medical books, for single herbs, and other natural products used for dementia, memory disorders, and memory improvement. This review explores how the terminology for these disorders has changed over time and which herbs have been used more or less frequently, and compares the results from the premodern literature with the herbs indexed for memory disorders in a modern pharmacopoeia. The searches located 731 citations deriving from 127 different books written between ca. 188 ad and ca. 1920. Of the 110 different natural products identified, those most frequently cited for forgetfulness were yuan zhi (Polygala tenuifolia), fu shen (Poria cocos), and chang pu (Acorus spp.), all of which have been cited repeatedly over the past 1800 years and appear among the 31 herbs indexed in a modern pharmacopoeia. By providing a complete, hierarchically organized list of herbs for a specific disorder, this approach can assist researchers in selecting herbs for research. PMID:23433049

May, Brian H; Lu, Chuanjian; Lu, Yubo; Zhang, Anthony L; Xue, Charlie C L



Genomic Alterations in Hodgkin’s Lymphoma  

Microsoft Academic Search

Cytogenetic analysis of Hodgkin’s lymphoma (HL) is hampered by the scarcity of neoplastic cells within a sea of reactive cells.\\u000a There is accumulating evidence that HL represents 2 disease entities, classic HL (cHL) with its morphologic variants and nodular\\u000a lymphocyte predominant HL (NLPHL). This subdivision, initially worked out in morphologic and immunohisto-chemical studies,\\u000a has been further substantiated by molecular cytogenetic

Marc A. Weniger; Thomas F. E. Barth; Peter Möller



Detection of ABCC1 expression in classical Hodgkin lymphoma is associated with increased risk of treatment failure using standard chemotherapy protocols  

PubMed Central

Background The mechanisms responsible for chemoresistance in patients with refractory classical Hodgkin lymphoma (CHL) are unknown. ATP-binding cassette (ABC) transporters confer multidrug resistance in various cancers and ABCC1 overexpression has been shown to contribute to drug resistance in the CHL cell line, KMH2. Findings We analyzed for expression of five ABC transporters ABCB1, ABCC1, ABCC2, ABCC3 and ABCG2 using immunohistochemistry in 103 pre-treatment tumor specimens obtained from patients with CHL. All patients received first-line standard chemotherapy with doxorubicin (Adriamycin®), bleomycin, vinblastine, and dacarbazine (ABVD) or equivalent regimens. ABCC1 was expressed in Hodgkin and Reed-Sternberg (HRS) cells in 16 of 82 cases (19.5%) and ABCG2 was expressed by HRS cells in 25 of 77 cases (32.5%). All tumors were negative for ABCB1, ABCC2 and ABCC3. ABCC1 expression was associated with refractory disease (p?=?0.01) and was marginally associated with poorer failure-free survival (p?=?0.06). Multivariate analysis after adjusting for hemoglobin and albumin levels and age showed that patients with CHL with HRS cells positive for ABCC1 had a higher risk of not responding to treatment (HR?=?2.84, 95%, CI: 1.12-7.19 p?=?0.028). Conclusions Expression of ABCC1 by HRS cells in CHL patients predicts a higher risk of treatment failure and is marginally associated with poorer failure-free survival using standard frontline chemotherapy regimens.



The NF-?B inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.  


The NF-?B inhibitor DHMEQ has shown preclinical activity in classical Hodgkin Lymphoma (cHL). Here we evaluated if DHMEQ could affect microenvironmental interactions and formation and improve the activity of drugs used in relapsed/refractory cHL. We demonstrated that DHMEQ down-regulated the NF-?B target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. Cytotoxicity, CD30 down-modulation and CD30 shedding by DHMEQ were prevented by ROS scavenger NAC. DHMEQ overcame stimuli from CD40 engagement and fibroblasts and enhanced doxorubicin, cisplatin and gemcitabine activity. Our results suggest that DHMEQ may be a promising agent for future therapeutic strategies in cHL. PMID:24704296

Celegato, Marta; Borghese, Cinzia; Umezawa, Kazuo; Casagrande, Naike; Colombatti, Alfonso; Carbone, Antonino; Aldinucci, Donatella



Aberrant T-cell antigen expression in classical Hodgkin lymphoma is associated with decreased event-free survival and overall survival  

PubMed Central

Hodgkin/Reed-Sternberg (HRS) cells of classical Hodgkin lymphoma (cHL) rarely express T-cell-associated antigens (TCA), but the clinical significance of this finding is uncertain. Fifty cHLs expressing any TCA on the HRS cells (TCA-cHL) were identified in two cohorts (National Cancer Institute, n = 38; Basel, n = 12). Diagnostic pathology data were examined in all cases with additional T-cell receptor ? rearrangements (TRG@) polymerase chain reaction (PCR) in a subset of cases. The outcome data were compared with a cohort of cHLs negative for TCA (n = 272). Primary end points examined were event-free survival (EFS) and overall survival (OS). The median age in the TCA-cHL group was 40 years (range, 10-85 years). Seventy percent presented in low stage (stage I/II) at presentation with nodular sclerosis (NS) histology predominating in 80% of cases. Among the TCA, CD4 and CD2 were most commonly expressed, seen in 80.4% and 77.4% of cases, respectively. TRG@ PCR was negative for clonal rearrangements in 29 of 31 cases. During a median follow up of 113 months, TCA expression predicted shorter OS (adjusted hazard ratio [HRadj] = 3.32 [95% confidence interval (CI): 1.61, 6.84]; P = .001) and EFS (HRadj = 2.55 [95% CI: 1.45, 4.49]; P = .001). TCA-cHL often display NS histology, lack T-cell genotype, and are independently associated with significantly shorter OS and EFS compared with TCA-negative cHLs.

Song, Joo Y.; Tzankov, Alexandar; Dirnhofer, Stephan; Heinze, Georg; Kohl, Maria; Traverse-Glehen, Alexandra; Eberle, Franziska C.; Hanson, Jeffrey C.; Raffeld, Mark A.; Pittaluga, Stefania; Jaffe, Elaine S.



Tumor Necrosis Factor-? Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study  

PubMed Central

Background Non-Hodgkin’s lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population. Method We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). Results We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR?=?3.03; 95% CI?=?1.68–5.45 for TT vs. CC and adjusted OR?=?2.03; 95% CI?=?1.53–2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40–60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin’s lymphoma was elevated for CT/TT genotypes (adjusted OR?=?1.95, 95% CI?=?1.41–2.70 for B cell NHL and adjusted OR?=?2.22, 95% CI?=?1.49–3.30 for T cell NHL), particularly for DLBCL (adjusted OR?=?2.01, 95%CI?=?1.41–2.85) and FL (adjusted OR?=?2.53, 95% CI?=?1.17–5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes. Conclusions The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results.

Zhang, Yan; Wang, Meng-Yun; He, Jing; Wang, Jiu-Cun; Yang, Ya-Jun; Jin, Li; Chen, Zhi-Yu; Ma, Xue-Jun; Sun, Meng-Hong; Xia, Kai-Qin; Hong, Xiao-Nan; Wei, Qing-Yi; Zhou, Xiao-Yan



A generic real-time TaqMan assay for specific detection of lapinized Chinese vaccines against classical swine fever.  


Classical swine fever (CSF) is a highly contagious disease, causing severe economic losses in the pig industry worldwide. Vaccination of pigs with lapinized Chinese vaccines is still practised in some regions of the world, where the virus is enzootic, in order to prevent and control the disease. However, a single real-time assay that can detect all lapinized Chinese vaccines used widely, namely, Lapinized Philippines Coronel (LPC), Hog Cholera Lapinized virus (HCLV) and the Riems C-strain is still lacking. This study describes a real-time RT-PCR assay, targeting the N(pro) gene region, for specific detection of these lapinized vaccine strains. The assay is highly sensitive, with a detection limit of 10 genome copies per reaction for HCLV and Riems C-strain and highly specific, as more than 100 strains of wild type CSFV representing all major genotypes were not detected. The assay is also highly repeatable: the coefficient of variation of Ct values in three runs was 2.77% for the detection of 10 copies of the vaccine viral RNA. This study provides a potentially useful tool for specific detection of the lapinized Chinese vaccines, HCLV and C-strain, and the differentiation of these vaccines from wild type CSFV. PMID:21600240

Liu, Lihong; Xia, Hongyan; Everett, Helen; Sosan, Olubukola; Crooke, Helen; Meindl-Böhmer, Alexandra; Qiu, Hua-Ji; Moennig, Volker; Belák, Sándor; Widén, Frederik



Doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy with interferon for advanced stage classic Hodgkin lymphoma: a 10-year follow-up study.  


Previous studies have shown that interferon-? (IFN-?) and chemotherapy is an effective treatment for patients with newly diagnosed follicular lymphoma. Therefore, we performed a phase II trial to determine the safety and effectiveness of IFN-? and standard doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy (IABVD) in these patients. Patients with newly diagnosed advanced stage classic Hodgkin lymphoma (HL) were enrolled between July 1997 and March 2000 on IABVD as initial therapy. This consisted of six cycles of ABVD with concurrent IFN-? followed by radiation therapy if indicated. IFN-? 6 million IU/m(2) was administered subcutaneously daily for 3 days and on day 4 patients received IFN-? with ABVD. Courses were repeated every 2 weeks for a maximum of 12 courses. IFN-? dose reduction was allowed for cytopenia. Outcome and baseline characteristics were reported. Thirty patients (median age, 30 years [range, 18-62 years]) were evaluable. Patients had Ann Arbor stage II (7%), III (30%) or IV (63%) disease, and 47% were at intermediate or high risk, as defined by the International Prognostic Score (? 2 vs. > 2). The 3-year event-free survival rate was 71% (95% confidence interval [CI], 56-90%), and the 3-year overall survival rate was 96% (95% CI, 89-100%). Treatment was well tolerated, with only three patients requiring IFN-? dose reduction or discontinuation because of cytopenia. IABVD is an effective regimen against advanced HL and is well tolerated. However, because of the emergence of effective new biologic agents, further development of this regimen is not warranted. PMID:22023528

Batty, Nicolas; Hagemeister, Fredrick B; Feng, Lei; Romaguera, Jorge E; Rodriguez, Maria A; McLaughlin, Peter; Samaniego, Felipe; Copeland, Amanda; Dabaja, Bouthaina S; Younes, Anas



Protective effects on myelosuppression mice treated by three different classic Chinese medicine formulae  

PubMed Central

Background: In order to observe the protective therapeutic action and mechanism of Liuwei Dihuang Decoction, Buzhong Yiqi Decoction, and Compound Danshen Decoction on Myelosuppression induced by cyclophosphamide. Materials and Methods: The mice model was established by intraperitoneal injected with 100 mg/kg cyclophosphamide by human and mice dose conversion on the 9th, 11th, 13th days during the experiment. Flow cytometry (FCM) was used for detecting the number of cells and investigating bone marrow cell cycles. Spleen was taken out and the mRNA expression level of thrombopoietin (TPO) and c-Mpl were detected by Q-PCR, and c-Mpl in spleen in order to discuss the mechanism of myelosuppression and the protective effects of traditional Chinese medicine. Results: Both Liuwei Dihuang Decoction Group and Buzhong Yiqi Decoction Group can accelerate bone marrow hematopoietic stem progenitor cells (HSPCs) in marrow-suppressed mice and enhance cell proliferation by promoting cell cycles from G0/G1 phase to access into S, G2/M phase. And at the same time these Chinese decoctions can increase the mRNA expression level of TPO and c-Mpl in spleen. Conclusion: Researched showed that Chinese formula take effect by affecting these genes on myelosuppressed mice.

Zhao, An-bin; YU, Bin; WU, Xian-Lin; Cao, Ke-Jian; LI, En-Qing; LI, Qing-Mei; Chen, Xiao-Yin



Hodgkin's disease  

SciTech Connect

The outlook for patients with Hodgkin's disease has improved dramatically over the past 20 years. The question is no longer whether cure is possible, but rather, how can cure be best achieved. With better understanding of the biology of Hodgkin's disease and with continued evolution of treatment approaches, the goal of curing all patients with Hodgkin's disease is clearly within reach. This article provides a summary of current concepts in the biology and management of Hodgkin's disease. Staging, treatment options, and complications of therapy are discussed.

Portlock, C.S.



Pathobiology of Hodgkin Lymphoma  

PubMed Central

Hodgkin’s lymphoma is a lymphoid tumour that represents about 1% of all de novo neoplasms occurring every year worldwide. Its diagnosis is based on the identification of characteristic neoplastic cells within an inflammatory milieu. Molecular studies have shown that most, if not all cases, belong to the same clonal population, which is derived from peripheral B-cells. The relevance of Epstein-Barr virus infection at least in a proportion of patients was also demonstrated. The REAL/WHO classification recognizes a basic distinction between nodular lymphocyte predominance HL (NLPHL) and classic HL (CHL), reflecting the differences in clinical presentation, behavior, morphology, phenotype, molecular features as well as in the composition of their cellular background. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, mixed cellularity and lymphocyte depleted. Despite its well known histological and clinical features, Hodgkin’s lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics and possible mechanisms of lymphomagenesis.

Agostinelli, Claudio; Pileri, Stefano



Hodgkin Lymphoma  


The Leukemia & Lymphoma Society (LLS) is the world's largest voluntary health agency dedicated to blood cancer. The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality ...


Focusing on the Classical or Contemporary? Chinese Science Teacher Educators' Conceptions of Nature of Science Content to Be Taught to Pre-service Science Teachers  

NASA Astrophysics Data System (ADS)

Drawing from the phenomenographic perspective, an exploratory study investigated Chinese teacher educators' conceptions of teaching Nature of Science (NOS) to pre-service science teachers through semi-structured interviews. Five key dimensions emerged from the data. This paper focuses on the dimension, NOS content to be taught to pre-service science teachers. A total of 20 NOS elements were considered by the Chinese science teacher educators to be important ideas to be taught. It was also found that among these educators, whether focusing on the classical or contemporary NOS elements in NOS instruction was a prominent controversy. After explaining the criteria for differentiating between classical and contemporary NOS elements, this paper reports the specific NOS elements suggested by Chinese science teacher educators in this study. Afterward, it describes how all educators in this study were categorized in term of NOS content taught by them to pre-service science teachers. In the end, it discusses three factors influencing the decision on NOS content to be taught, i.e., view of the concept of NOS itself, vision of teaching NOS, and belief in general philosophy.

Wan, Zhi Hong; Wong, Siu Ling; Wei, Bing; Zhan, Ying



Hodgkin Disease  


... Night sweats Weight loss Loss of appetite Itchy skin To diagnose Hodgkin disease, doctors use a physical exam and history, blood tests, and a biopsy. Treatment depends on how far the disease has spread. It often includes radiation therapy or chemotherapy. The earlier the disease is diagnosed, ...


Non-Hodgkin lymphoma  


Lymphoma - non-Hodgkin; Lymphocytic lymphoma; Histiocytic lymphoma; Lymphoblastic lymphoma; Cancer - non-Hodgkin lymphoma ... National Cancer Institute: PDQ Adult Non-Hodgkin Lymphoma ... Available at ...


Primary bony Hodgkin's lymphoma  

PubMed Central

Hodgkin’s lymphoma most commonly presents with progressive painless enlargement of peripheral lymph nodes, especially around the cervical region. At the time of diagnosis osseous involvement is uncommon and even in the late stages only 9–35% of cases have any bony involvement. Rarely Hodgkin’s lymphoma presents as an osseous lesion without involvement of lymph nodes, therefore the histological diagnosis of osseous Hodgkin’s lymphoma can be problematic. Here, the authors present a rare case of primary osseous Hodgkin’s lymphoma and a review of the literature.

Binesh, Fariba; Mirjalili, Mohammad Reza; Akhavan, Ali; Navabii, Hossein



Hodgkin lymphoma  

PubMed Central

Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In HL, the tumor cells — Hodgkin and Reed-Sternberg (HRS) cells — are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-?B and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies.

Kuppers, Ralf; Engert, Andreas; Hansmann, Martin-Leo



Expression profiling of transcription factors Pax5, Oct-1, Oct-2, BOB.1, and PU.1 in Hodgkin's and non-Hodgkin's lymphomas: a comparative study using high throughput tissue microarrays  

Microsoft Academic Search

Analysis of B-cell-specific transcription factors is useful in understanding of the differentiation-linked phenotype in Hodgkin's as well as in non-Hodgkin's lymphomas. We analyzed the expression profiling of transcription factors Pax-5, Oct-1, Oct-2, BOB.1, and PU.1 in 109 cases, including non-Hodgkin's lymphomas of B- and T-lineage, classical Hodgkin's lymphomas, and nodular lymphocyte predominant Hodgkin's lymphomas. Our study revealed that all transcription

Ryan C McCune; Sergei I Syrbu; Mohammad A Vasef



CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin's lymphoma  

PubMed Central

Background Advances in the understanding of Hodgkin's lymphoma (HL) show various functions of infiltrating immune cells and cytokines in relation to clinical outcomes. The expression of CD163 and c-Met has been suggested to have a role in lymphoid malignancy. Thus, we evaluated the expressions of CD163, c-Met, and serum free light chain (sFLC) in relation to the clinicopathological features of patients with advanced classical HL (cHL). Methods We assessed the expression of CD163 and c-Met in 34 patients with cHL through immunohistochemistry on the lymph node biopsy sections and the levels of pretreatment sFLC were estimated using ELISA. Results High CD163 expression correlated with increased age, B symptoms, International Prognostic Score (IPS) ?3, mixed cellularity subtype, and low response to treatment. Further, high c-Met expression correlated with increased age at diagnosis, leukocytosis, B symptoms, and lower chance to achieve complete remission. The sFLC levels correlated with increased age at diagnosis, lymphopenia, IPS ?3, B symptoms, and lower complete remission rates. Conclusion In advanced cHL, increased expression of CD163 and c-Met showed a significant association with adverse prognostic parameters and poor response to treatment. Pretreatment high sFLC level also correlated with poor risk factors, suggesting its use as a candidate prognostic marker. A comprehensive approach for prognostic markers might represent a step towards developing a tailored therapeutic approach for HL.

Bedewy, Magdy; El-Maghraby, Shereen



Lack of phylogenetic evidence that the Shimen strain is the parental strain of the lapinized Chinese strain (C-strain) vaccine against classical swine fever.  


The Chinese hog cholera lapinized virus (HCLV), also called the "Chinese strain" or "C-strain" of classical swine fever virus (CSFV), was developed in China in the 1950s. There are uncertainties about the genetic heterogeneity and origin of this vaccine virus. The objectives of this study were to investigate the genetic heterogeneity of the C-strain, for which nucleotide sequences have been submitted to GenBank from different laboratories, and to determine whether there is any evidence to support the hypothesis that the C-strain originated from the Shimen strain. Analysis of 150 nearly complete E2 gene sequences revealed that the C-strain clade includes several HCLV vaccine strains, cell-culture-adapted Riems strains, and viruses isolated from diseased pigs. The whole-genome phylogeny indicated that the ancestor of the C-strain was only distantly related to the Shimen strain. Therefore, there was no phylogenetic evidence to support the Shimen-origin hypothesis. PMID:21340740

Xia, Hongyan; Wahlberg, Niklas; Qiu, Hua-Ji; Widén, Frederik; Belák, Sándor; Liu, Lihong




PubMed Central

In the last few years, there has been a greater understanding of the spectrum and biology of Hodgkin lymphoma. In standard texts, Hodgkin lymphoma is classified as two distinct entities, namely nodular lymphocyte predominant Hodgkin lymphoma and classical Hodgkin lymphoma. However, recent evidence suggests that classical Hodgkin lymphoma is not a single disease. While the mixed cellularity and lymphocyte depleted subtypes may be part of a biologic continuum, the nodular sclerosis subtype has a distinct epidemiology, clinical presentation and histology. Nodular sclerosis Hodgkin lymphoma may also be related to primary mediastinal B-cell lymphoma and mediastinal grey zone lymphomas. We present an update on the pathobiology of Hodgkin lymphoma and discuss these biologic and clinical differences in this review.

Mani, Haresh; Jaffe, Elaine S.



Evaluation of a real-time RT-PCR assay using minor groove binding probe for specific detection of Chinese wild-type classical swine fever virus.  


A one-step real-time RT-PCR assay using a minor groove binding probe was developed for the specific detection of Chinese wild-type classical swine fever virus (CSFV). The assay detected wild-type CSFV strains representing different genotypes, but did not amplify viral RNA from the Hog Cholera Lipinized Virus (HCLV) vaccine-strain and other porcine viruses. The assay had a detection limit of 10 copies/reaction or 3.0 median tissue culture infective dose/reaction. In comparison to the sequencing nested RT-PCR assay, the sensitivity and specificity of the assay were 98.3% and 94.3%, respectively, when testing 515 veterinary samples. Wild-type CSFV RNA was detected in nasal swabs 2-4 days before detection in serum samples from pigs exposed to infection by contact, and 2-4 days prior to the onset of clinical disease. HCLV RNA remained undetectable in nasal swabs and serum samples from vaccinated pigs. In conclusion, the novel assay described in this study provides a rapid and sensitive method for differentiating between wild-type and the HCLV-strain of CSFV. It could be used for monitoring in CSF outbreak areas or as a screening method for CSFV eradication strategies. PMID:21723883

Wen, Guoyuan; Zhang, Tao; Yang, Jun; Luo, Qingping; Liao, Yonghong; Hu, Zhibin; Zhang, Rongrong; Wang, Hongling; Ai, Diyun; Luo, Ling; Song, Nianhua; Shao, Huabin



[Primary Hodgkin's lymphoma of the colon].  


Primary Hodgkin's lymphoma of the colon is exceedingly rare. We report on the case of a 74-year-old female patient presenting with weight loss and hematochezia. Proctocolonoscopy revealed a bleeding tumor localized in the right colonic flexure. Histological examination of initial mucosal biopsies could not verify malignancy; however, explorative surgery was decided in an interdisciplinary conference setting and right-sided hemicolectomy was performed. Macroscopically, a tumor measuring 5.5 cm in maximum diameter was found. By means of histology and immunohistochemistry the diagnosis of classic Hodgkin's lymphoma was made. Mesenteric lymph nodes were not affected and postoperative staging revealed no systemic spread. Therefore, the tumor fulfilled the criteria of a primary colonic Hodgkin's lymphoma. Diagnosis of primary colonic lymphoma can be difficult as clinical symptoms are typically unspecific and, as shown in this case, even primary biopsy histology can be falsely negative. PMID:23793289

Hansen, T; Hartmann, F; Hiller, W; Schütz, M; Oschlies, I



Chinese Herbalism  

PubMed Central

Chinese herbalism dates back to 2852 B.C. More than 2,600 herbs and thousands of herbal formulae are used to treat illness. Classical theories of Chinese medicine are integrated with the Taoist philosophy, whereby the universe is composed of two basic forces: a positive one called yang, and a negative one called yin. Illness is thought to occur when there is too much yang (tonification) or too much yin (sedation) in the body and herbal medicines are therefore intended either to tonify or to sedate the body so that balance is restored. Since 1954, some Chinese herbal remedies have been scientifically analyzed and tested. Several have been proven effective in treating a variety of diseases and conditions.

Cheng, Richard



Sarcoid Reactions after Chemotherapy for Hodgkin's Lymphoma  

PubMed Central

Introduction There is a reported association between sarcoidosis and malignancy. This is particularly true for lymphomas and is known as the sarcoidosis-lymphoma syndrome. Case report A 49 year old Caucasian female presented with mediastinal and axillary lymphadenopathy. An excisional axillary lymph node biopsy showed classical Hodgkin’s lymphoma, nodular sclerosis subtype. She received six cycles of conventional chemotherapy achieving a complete remission with no evidence of any lymphadenopathy on restaging imaging. However, one month after completion of chemotherapy, she developed new onset of progressive mediastinal lymphadenopathy. A mediastinoscopy and biopsy was performed showing noncaseating granulomata and the patient was diagnosed with a sarcoid reaction. Conclusion Sarcoidosis and sarcoid reactions must be considered in the differential diagnosis when assessing patients with persistent or enlargening masses after chemotherapy treatment for Hodgkin’s lymphoma, especially since this is associated with a better prognosis. A tissue biopsy is essential prior to starting chemotherapy for presumed relapsed malignancy or persistent disease so as to avoid inappropriate treatment.

Wirk, Baldeep



Radiation therapy for Hodgkin lymphoma.  


The long-term cardiac complications of radio(chemo)therapy for Hodgkin lymphoma include coronary artery disease, cardiac arrhythmias, valvular disease, pericardial disease, cardiomyopathy and heart failure. The extent of myocardial damage after radiotherapy is dependent on the dose, the volume and the technique of chest irradiation. Also, patient-specific factors, such as the age of the patient at the time of treatment and the presence of classical cardiac risk factors are supposed to be important. The relative risk of cardiovascular events is estimated to be 2 to 7 times higher than the general population. The patient's clinical picture can vary from asymptomatic to an acute presentation of end-stage coronary artery or valvular disease. PMID:24783474

Everaert, Bert R; Van den Heuvel, Paul



Determination of AntiTumor Constitute Mollugin from Traditional Chinese Medicine Rubia cordifolia: Comparative Study of Classical and Microwave Extraction Techniques  

Microsoft Academic Search

Rubia cordifolia is a common traditional Chinese medicine (TCM) used for centuries for the treatment of cough, inflammation of the joints, uterine hemorrhage, and uteritis. Mollugin is a major active component present in R. cordifolia and recognized as a potential anti-tumor compound. In this work, a microwave-assisted extraction (MAE) method has been developed for extracting mollugin from R. cordifolia. Several

Wenyan Ma; Yanbin Lu; Xiaojing Dai; Rui Liu; Ruilin Hu; Yuanjiang Pan



Vorinostat in Treating Patients With Relapsed or Refractory Advanced Hodgkin's Lymphoma

Adult Favorable Prognosis Hodgkin Lymphoma; Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Adult Unfavorable Prognosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma



Outcome of children and adolescents with recurrent/refractory classical Hodgkin lymphoma, a study from the Société Française de Lutte contre le Cancer des Enfants et des Adolescents (SFCE).  


There is little data available regarding children and adolescents with Hodgkin lymphoma (HL) who relapse after combined-modality treatment, even though they have a substantial chance of cure. The purpose of this national retrospective study was to evaluate the outcome of patients with recurrent/refractory HL and determine adverse prognostic factors. From 1990 to 2006, 70 patients (median age 13·9 years) with refractory (n = 31) or first relapse (n = 39) HL were identified. Median time from end of treatment to relapse was 6 months (3-56). Relapses occurred in irradiated areas in 43/70 patients. Salvage therapy consisted of chemotherapy and 50 patients received high-dose chemotherapy with autologous stem cell transplantation. Radiotherapy was performed in 29 cases, tandem autologous transplantation in five and allograft in three. With a median follow-up of 40 months (2-140), significant prognostic factors were time to progression/relapse and response to therapy before autograft. Event-free survival and overall survival in patients with refractory disease, early relapse and late relapse were 35 ± 9%, 67 ± 11%, 76 ± 10% and 48 ± 11%, 89 ± 7% and 80 ± 10%, respectively. As progression <3 months was a major adverse prognostic factor, novel therapeutic approaches are needed for this group of patients. By contrast, patients have substantial chance of long term second remission in case of relapse >3 months. PMID:22757721

Gorde-Grosjean, Stéphanie; Oberlin, Odile; Leblanc, Thierry; Pacquement, Hélène; Donadieu, Jean; Lambilliotte, Anne; Schell, Mathias; Dommange, Florence; Munzer, Martine; Paillard, Catherine; Schmitt, Claudine; Lutz, Patrick; Edan, Christine; Ansoborlo, Sophie; Stephan, Jean-Louis; Michel, Gérard; Thomas, Caroline; Perel, Yves; Robert, Alain; Landman-Parker, Judith



Hodgkin's disease in children.  


This study provides information about histological types of Hodgkin's disease (HD) among children of Pakistan. Hodgkins disease constitutes 12 per cent of all pediatric malignant tumours. The peak incidence is between 6 and 10 years. The male to female ratio is 5.25:1. The majority (78 per cent) present with cervical lymphadenopathy. Mixed cellularity (MC) is the commonest histological type. In the developed countries nodular sclerosis (NS) and lymphocyte predominant (LP) subtypes are more common, and which have better prognosis. The developing countries have a higher incidence of poor prognostic subtypes. Our study indicates a situation intermediate between the two. PMID:1527813

Ahmed, M; Khan, A H; Saleem, S; Mansoor, A



How Is Non-Hodgkin Lymphoma Staged?  


... for non-Hodgkin lymphoma How is non-Hodgkin lymphoma staged? Once non-Hodgkin lymphoma is diagnosed, tests ... A is added to the stage. Small lymphocytic lymphoma (SLL) /chronic lymphocytic leukemia (CLL) The Ann Arbor ...


Lymphocyte-Predominant Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Lymphocyte-predominant Hodgkin lymphoma (LPHL) was first described in 1944 by Jackson and Parker as nodular paragranuloma\\u000a [1]. Other synonyms used were lymphocytic predominant Hodgkin disease, lymphocytic and histiocytic (L&H) predominant Hodgkindisease,\\u000a nodular lymphocyte-predominant Hodgkin disease, and nodular LPHL [2–5]. This term has become the one that is currently being\\u000a used. LPHL represents 5% of all HL cases and is a

Andreas Engert; Anas Younes



Microsoft Academic Search

Background. There is strong evidence that Reed-Sternberg cells have a lymphoid phenotype, but clonally rearranged genes for B-cell and T-cell antigen receptors have not been demonstrable in tumor tissue from most patients with Hodgkin's disease. To elucidate this issue, we assayed single Reed-Sternberg cells from 12 patients with classic Hodgkin's disease of a B-cell im- munophenotype to detect rearranged immunoglobulin




Anti-CD30 Antibodies for Hodgkin Lymphoma  

Microsoft Academic Search

Treatment of refractory or relapsed classical Hodgkin lymphoma (HL) remains challenging, but targeted immunotherapy has recently\\u000a emerged as a potential treatment option for these patients. Although first-generation monoclonal anti-CD30 antibodies proved\\u000a disappointing, current efforts to modify anti-CD30 antibodies to improve binding of effector cells and enhance activity appears\\u000a more promising, as does the development of novel antibody-drug conjugates (ADCs). ADCs

Kelley V. Foyil; Nancy L. Bartlett



Fumanjian, a Classic Chinese Herbal Formula, Can Ameliorate the Impairment of Spatial Learning and Memory through Apoptotic Signaling Pathway in the Hippocampus of Rats with A?1–40-Induced Alzheimer's Disease  

PubMed Central

Alzheimer's disease (AD) is the most common form of dementia and lacks disease-altering treatments. Fumanjian (FMJ), a famous classic Chinese herbal prescription for dementia, was first recorded in the Complete Works of Jingyue during the Ming Dynasty. This study aimed to investigate whether FMJ could prevent cognitive deficit and take neuroprotective effects in A?1–40-induced rat model through apoptotic signaling pathway. AD model was established by bilateral injection of A?1–40 into hippocampus in rat. All rats were tested for their capabilities of spatial navigation and memorization by Morris water maze. Apoptosis was tested using TUNEL staining in hippocampus neuronal cells; RT-PCR tested expression of Bcl-2 and Bax mRNA; western blotting tested protein level of cleaved caspase-3. After 14 days of treatment, FMJ significantly improved the escape latency and enhanced platform-cross number compared with the A?1–40-injected group (P < 0.05 or P < 0.01). FMJ also significantly decreased number of TUNEL-positive neuronal apoptosis and the expressions of Bax and cleaved Caspase-3 and increased the expression of Bcl-2 (P < 0.01) compared with AD model group. In conclusion, FMJ exerts a protective effect against A?1–40-induced learning and memory deficits and neuronal apoptosis, suggesting that FMJ could be used as a potential therapeutic formula for AD.

Hu, Hai-yan; Cui, Zhi-hui; Li, Hui-qin; Wang, Yi-ru; Chen, Xiang; Li, Ji-huang; Xv, Dong-mei



Classical antiparticles.  

National Technical Information Service (NTIS)

We review how antiparticles may be introduced in classical relativistic mechanics, and emphasize that many of their paradoxical properties can be more transparently understood in the classical than in the quantum domain. (authors) . 13 refs., 1 tab.

J. P. Costella B. H. J. McKellar A. A. Rawlinson



What You Need to Know about Non-Hodgkin Lymphoma  


What You Need To Know About™ Non-Hodgkin Lymphoma In English En español Posted: 02/12/2008 ... Trials NCI Publications Español What Is Non-Hodgkin Lymphoma? Non-Hodgkin Lymphoma Cells Non-Hodgkin lymphoma is ...


How Is Non-Hodgkin Lymphoma Staged in Children?  


... Hodgkin lymphoma treated in children? How is non-Hodgkin lymphoma staged in children? Once non-Hodgkin lymphoma ( ... instead of lymphoma.) Survival rates for childhood non-Hodgkin lymphoma Advances in treatment have increased the overall ...


Hodgkin-Huxley Model  

NSDL National Science Digital Library

The Hodgkin Huxley Model shows the neuron voltage within the cell of a squid giant axon. This voltage is due to the currents flowing into the neuron and charging the capacitance of the lipid bilayer cell wall. Currents into the neuron are based on sodium and potassium ions flowing into and out of the neuron based on voltage-gates channels in the cell wall. The flow of these ions is determined by dimensionless variables that represent the probability a potassium, sodium activation, or sodium inactivation gate is opened, respectively. This model allows these parameters to be set by the user. The Hodgkin Huxley Model was developed using the Easy Java Simulations (EJS) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the jar file will run the program if Java is installed. You can modify this simulation if you have EJS installed by right-clicking within the map and selecting "Open Ejs Model" from the pop-up menu item.

Thomson, Colin F.



Recurrent somatic mutations of PTPN1 in primary mediastinal B cell lymphoma and Hodgkin lymphoma.  


Classical Hodgkin lymphoma and primary mediastinal B cell lymphoma (PMBCL) are related lymphomas sharing pathological, molecular and clinical characteristics. Here we discovered by whole-genome and whole-transcriptome sequencing recurrent somatic coding-sequence mutations in the PTPN1 gene. Mutations were found in 6 of 30 (20%) Hodgkin lymphoma cases, in 6 of 9 (67%) Hodgkin lymphoma-derived cell lines, in 17 of 77 (22%) PMBCL cases and in 1 of 3 (33%) PMBCL-derived cell lines, consisting of nonsense, missense and frameshift mutations. We demonstrate that PTPN1 mutations lead to reduced phosphatase activity and increased phosphorylation of JAK-STAT pathway members. Moreover, silencing of PTPN1 by RNA interference in Hodgkin lymphoma cell line KM-H2 resulted in hyperphosphorylation and overexpression of downstream oncogenic targets. Our data establish PTPN1 mutations as new drivers in lymphomagenesis. PMID:24531327

Gunawardana, Jay; Chan, Fong Chun; Telenius, Adèle; Woolcock, Bruce; Kridel, Robert; Tan, King L; Ben-Neriah, Susana; Mottok, Anja; Lim, Raymond S; Boyle, Merrill; Rogic, Sanja; Rimsza, Lisa M; Guiter, Chrystelle; Leroy, Karen; Gaulard, Philippe; Haioun, Corinne; Marra, Marco A; Savage, Kerry J; Connors, Joseph M; Shah, Sohrab P; Gascoyne, Randy D; Steidl, Christian



Gemcitabine and Bendamustine in Patients With Relapsed or Refractory Hodgkin's Lymphoma

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma



A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma



Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma

Childhood Favorable Prognosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma



Treatment of Advanced Stage Hodgkin’s Disease  

Microsoft Academic Search

Hodgkin’s disease remains one of the few malignant diseases which can be cured by modern chemotherapy in most cases even in advanced stages. Adriamycin-containing chemotherapy regimens are considered as the standard therapy which induce long-term remission in about 60–70% of patients. The ABVD scheme, developed by Bonadonna and colleagues in Milan, has a favorable toxicity profile and causes less myelotoxicity,

H. Tesch; M. Sieber; V. Diehl



Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma  

PubMed Central

Up to 40% of patients with advanced Hodgkin lymphoma (HL) become refractory or relapsed after current standard chemotherapy, among which primary refractory HL confers a particularly poor outcome. With intensive salvage chemotherapy and autologous stem cell transplantation, the long-term remission rate for these patients was only 30%, but more selective treatments with higher therapeutic index are needed. We report the experience of using a new anti-CD30 immunotoxin, brentuximab vedotin, in salvage treatment of a 30-year-old woman with primary refractory Hodgkin lymphoma. The patient presented with SVC syndrome due to the bulky mediastinal tumor and was confirmed to have classical Hodgkin lymphoma, nodular sclerosis type, stage IIIA. The tumor responded to induction chemotherapy transiently, but local progression was noted during subsequent cycles of treatment. Salvage radiotherapy to the mediastinal tumor, obtained no remission but was followed by rapid in-field progression and then lung metastasis. She declined stem cell transplantation and received salvage brentuximab vedotin (BV) therapy, which induced dramatic shrinkage of tumor without significant side effects. Serial followup of PET/CT imaging confirmed a rapid and continuous complete remission for 12 months. Although durability of the remission needs further observation, this case illustrates the excellent efficacy of brentuximab vedotin in primary refractory Hodgkin lymphoma.

Yeh, Shyh-An; Chen, Huei-Yung



Encéphalite limbique révélatrice d’une maladie de Hodgkin  

Microsoft Academic Search

Introduction. – Malignancy is a possible cause of unexplained encephalitis.Exegesis. – We describe a 59-years-old woman with limbic encephalitis, not explained by other causes, preceding diagnosis of Hodgkin’s disease. Successful treatment of Hodgkin’s disease was effective against neurological disturbance.Conclusion. – This case provides evidence that Hodgkin’s disease can be uncovered by paraneoplastic limbic encephalitis.

P Bernard; S Vinzio; F Talarmin; A Kadouri; F Flocard



How Is Hodgkin Disease Diagnosed?  


... be being tired all the time. Cough, trouble breathing, chest pain If Hodgkin disease affects lymph nodes ... and make you cough or even have trouble breathing, especially when lying down. Some people may have ...


Stages of Adult Hodgkin Lymphoma  


... level (below 10.5). Having a high white blood cell count (15,000 or higher). Having a low lymphocyte ... 600 or less than 8% of the white blood cell count). Advanced Unfavorable Advanced unfavorable Hodgkin lymphoma is stage ...


Primary spinal epidural Hodgkin's lymphoma  

PubMed Central

Primary spinal epidural Hodgkin's lymphoma is very rare. We will discuss the clinical features and treatment of primary spinal epidural Hodgkin's lymphoma. In this paper, a 30-year-old male patient who presented with spinal epidural tumor at the T9–11 level is reported. Subtotal resection of the tumor was performed and the histological examination of the tumor specimen revealed Hodgkin's lymphoma. All other examinations were negative for an occult disease. Six courses of chemotheraphy containing adriamycin, bleomycin, vinblastine and dacarbazine were given to the patient. Surgery is the first therapeutic approach in malignancies compressing the spinal cord. Hodgkin's lymphoma is a very chemo- and radio-sensitive tumor. The indications for surgery were reduced and limited to laminectomy or even biopsy only, leaving the major role to chemo- and radiotheraphy.

Yaman, Onur; Ozdemir, Nail; Sevin, Ismail Ertan; Ozer, Fusun Demircivi; Unluoglu, Saime



Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma



Familial Hodgkin's lymphoma in Scandinavia.  


From 2005 to 2010, eight families with clustering of Hodgkin's lymphoma and other lymphoproliferative disorders were found: Hodgkin's lymphoma 9 cases, chronic lymphocytic leukemia 8, non-Hodgkin's lymphoma 3, and multiple myeloma 1 case. Seven cases of Hodgkin's lymphoma, all males, were seen in pleiotropic pairs of affected family members from two successive generations; two patients were sisters. Five of the seven pairs showed sign of anticipation. The 7 males with Hodgkin's lymphoma were found in 5 patrilineal pairs and 2 matrilineal pairs; 6 parent-offspring pairs and 1 uncle-nephew pair. In contrast to the matrilineal pairs, all patrilineal pairs, apart from one family with an only child, had healthy older siblings in accordance with a birth-order effect. The association among Hodgkin's lymphoma, males, and other lymphoproliferative disorders undoubtedly reflects genotypic traits of the susceptibility. A non-Mendelian segregation is discussed comprising genomic parental imprinting and incomplete penetrance susceptibility in both familial and solitary cases. PMID:21576419

Jønsson, Viggo; Awan, Haneef; Nyquist, Emil; Maisenhølder, Martin; Johannesen, Tom B; Ly, Bernt; Tjønnfjord, Geir E



[Particularities of Hodgkin's lymphoma].  


A risk-adapted strategy for adult patients with Hodgkin's lymphoma is based on risk factors at diagnosis. First line chemotherapy with the gold standard ABVD regimen, with 3 or 4 courses for patients without or with risk factors, respectively, followed by radiation therapy targeting the initially affected areas (involved-field RT), at a dose of 30 Gy, is the treatment of choice for all early-stage supradiaphragmatic disease. Treatment for disseminated disease is based on chemotherapy alone. According to prognostic index, 8 cycles of ABVD or more intensive regimen like BEACOP are indicated. At the present time, clinical trials including PET scans to evaluate early response to chemotherapy, aim to treat early stages with chemotherapy alone and modern radiation techniques are being developed to restrict the target volume to initially involved nodes only. For advanced stages, PET scan may help to define optimal treatment and primary failures from first line chemotherapy. PMID:20222316

Mounier, Nicolas; Fermé, Christophe



Primary extra nodal Hodgkin disease: Bone presentation  

PubMed Central

Summary Background Extra nodal and extra lymphatic propagation of Hodgkin’s disease is a characteristic of the fourth stage of disease when the organs are affected. Primary appearances of the disease outside the lymph node is a rare event. Therefore, it makes diagnostic problem. Skeletal system is possible localization of primary extra nodal Hodgkin’s disease. Case Report Women, 42-years-old, was admitted to hospital because of swelling and pain in the right shoulder. After imaging and histological examination diagnosed Hodgkin’s nodular sclerosing histological subtype disease has been established. The patient starts to receive chemotherapy. Conclusions Primary extra nodal Hodgkin’s disease of bone is manifested with painful swelling in geared area. Imaging method shows destruction of the affected bone, with swelling of the soft tissues. Propagation in soft tissue is not accompanied by their destruction, but rather manifested swelling of the surrounding soft tissue.

Nikolica, Goran; Badnjar, Zorka; Cadjenovic, Tanja; Raceta-Masic, Dijana



Hodgkin Lymphoma in Adults (Beyond the Basics)  


... hodgkin ) American Society of Clinical Oncology ( ) Literature review current through: May ... connected by lymph vessels. Graphic 63854 Version 4.0 Cotswolds staging classification for Hodgkin lymphoma Stage I - ...


Autoimmune hemolytic anaemia in Hodgkin's lymphoma.  


Autoimmune hemolytic anaemia is a rare presentation of Hodgkin's lymphoma though its association with Non- Hodgkin's lymphoma is well known. It is usually detected at the time of diagnosis when it accompanies Hodgkin's and rarely precedes it. It is a warm immune hemolytic anemia which is responsive to steroids and rituximab. We hereby report a case of advanced Hodgkin's disease who presented as AIHA. PMID:24772757

Shah, Mihir B; Nanjapp, Veena; Devaraj, H S; Sindhu, K S



Classical Tachyons.  

National Technical Information Service (NTIS)

A review of tachyons, with particular attention to their classical theory, is presented. The extension of Special Relativity to tachyons in two dimensions is first presented; an elegant model-theory which also allows a better understanding of ordinary phy...

E. Recami



Chinese Literature  

ERIC Educational Resources Information Center

The earliest recorded Chinese literature that has survived consists of folk songs mixed with verses and rhymes. Two factors determined the general pattern of subsequent development in Chinese literature: the nature of the written Chinese language and the establishment of the Confucian school as the orthodoxy in literary criticism. By 1800 there…

Hsu, Kai-yu


Things Chinese.  

ERIC Educational Resources Information Center

Presented in this booklet are brief descriptions of items and activities that are symbolic of Chinese culture. Some of the items and activities described include a traditional Chinese child's outfit, dolls, sandalwood fans, writing and printing materials and techniques, toys and crafts, a Chinese abacus, and eating utensils. Several recipes for…

Law, Yip Wang


Hodgkin's Lymphoma Presenting as Alopecia.  


Alopecia is a rare manifestation of Hodgkin's disease. It may be due to follicular destruction due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. In this patient, hair loss, diffuse yperpigmentation, and generalized itching preceded other manifestations of the disease. The pattern of hair loss was diffuse and generalized in nature involving scalp, eyebrows, axilla, and groin. Subsequently, the patient was diagnosed to be a case of Hodgkin's lymphoma, based on clinical and histopathological features. Earlier reports on alopecia accompanying Hodgkin's disease have also been discussed. This case highlights the importance of keeping a high suspicion of an underlying malignancy in patients presenting with such cutaneous manifestations. PMID:23180928

Garg, Sunny; Mishra, Sourav; Tondon, Ravi; Tripathi, Kamlakar



Hodgkin's Lymphoma Presenting as Alopecia  

PubMed Central

Alopecia is a rare manifestation of Hodgkin's disease. It may be due to follicular destruction due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. In this patient, hair loss, diffuse yperpigmentation, and generalized itching preceded other manifestations of the disease. The pattern of hair loss was diffuse and generalized in nature involving scalp, eyebrows, axilla, and groin. Subsequently, the patient was diagnosed to be a case of Hodgkin's lymphoma, based on clinical and histopathological features. Earlier reports on alopecia accompanying Hodgkin's disease have also been discussed. This case highlights the importance of keeping a high suspicion of an underlying malignancy in patients presenting with such cutaneous manifestations.

Garg, Sunny; Mishra, Sourav; Tondon, Ravi; Tripathi, Kamlakar



Lymphocyte-predominant Hodgkin's disease. An immunohistochemical analysis of 208 reviewed Hodgkin's disease cases from the German Hodgkin Study Group.  

PubMed Central

There is wide consensus that lymphocyte predominance Hodgkin's disease (LPHD) represents a distinct clinicopathological entity of B-cell origin. However, inconsistent results of immunophenotyping studies and low confirmation rates among multi-center trials pose the question of whether LPHD really expresses heterogeneous marker profiles or whether it represents a mixture of morphologically similar entities. Among 2,836 cases reviewed by the German Hodgkin Study Group, immunophenotyping was performed on 1) cases classified or confirmed as LPHD by the reference panel (n = 104) or 2) cases not confirmed as LPHD but classified as classical HD (cHD) within the reference study trial (n = 104). In most cases, immunohistochemistry revealed a phenotype either LPHD-like (CD20+, CD15-, CD30-, CD45+) or cHD-like (CD15+, CD30+, CD20-, CD45-). In 27 cases, the immunophenotype was not fully conclusive. Additional markers for Epstein-Barr virus and CD57 and in situ hybridization for mRNA light chains allowed for a more clear-cut distinction between LPHD and cHD. However, in 25 of 104 cases, immunohistochemistry disproved the morphological diagnosis of LPHD of the panel experts, whereas 13 cases originally not confirmed as LPHD showed a LPHD-like immunopattern. Immunohistochemically confirmed LPHD cases showed a significantly better freedom from treatment failure (P = 0.033) than cHD; this was not observed in the original study classification based only on morphology (P > 0.05). Significantly better survival for LPHD cases improved from P = 0.047 (original study classification) to P = 0.0071 when classified by immunohistochemistry. Our results show that LPHD is a more immunohistochemical rather than a purely morphological diagnosis. Immunophenotyping of HD biopsies suspected of being LPHD is mandatory when a modified therapy protocol, that is, one different from those used in cHD, is discussed. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5

von Wasielewski, R.; Werner, M.; Fischer, R.; Hansmann, M. L.; Hubner, K.; Hasenclever, D.; Franklin, J.; Sextro, M.; Diehl, V.; Georgii, A.



Classical Novae  

NASA Astrophysics Data System (ADS)

Preface; 1. Novae - a historical perspective Hilmar W. Duerbeck; 2. Properties of novae: an overview Brian Warner; 3. The evolution of nova-producing binary stars Icko Iben, Jr and Masayuki Y. Fujimoto; 4. Thermonuclear processes S. Starrfield, C. Iliadis and W. R. Hix; 5. Nova atmospheres and winds P. H. Hauschildt; 6. Observational mysteries and theoretical challenges Jordi Jose and Steven N. Shore; 7. Radio emission from novae E. R. Seaquist and M. F. Bode; 8. Infrared studies of classical novae Robert D. Gehrz; 9. Optical and ultraviolet evolution Steven N. Shore; 10. X-ray emission from classical novae in outburst Joachim Krautter; 11. Gamma-rays from classical novae Margarita Hernanz; 12. Resolved nova remnants T. J. O'Brien and M. F. Bode; 13. Dust and molecules in nova environments A. Evans and J. M. C. Rawlings; 14. Extragalactic novae Allen Shafter; Index.

Bode, Michael F.; Evans, Aneurin



How Is Hodgkin Disease Staged?  


... could cause problems if you have this infection Bone marrow aspiration and biopsy If Hodgkin disease has been diagnosed, these tests ... if it is in the bone marrow. The bone marrow aspiration and biopsy are usually done at the same time. The ...


Pregnancy complicated by Hodgkin's disease.  


Hodgkin's disease (HD) in association with pregnancy is rarely reported. Thus, the data in the management of pregnancy complicated by HD is limited. We report here the management of advanced HD in pregnancy that was treated successfully with chemotherapy. PMID:17240590

Fadilah, S A W; Leong, C F; Jamil, M Y M A; Cheong, S K; Rozilaila, R



Drugs Approved for Hodgkin Lymphoma

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.


Bortezomib, Ifosfamide, and Vinorelbine Tartrate in Treating Young Patients With Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Therapy

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Lymphocyte Predominant Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma



What Are the Key Statistics about Non-Hodgkin Lymphoma?  


... for non-Hodgkin lymphoma? What are the key statistics about non-Hodgkin lymphoma? Non-Hodgkin lymphoma (NHL) ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...


What's New in Non-Hodgkin Lymphoma Research and Treatment?  


... Topic Additional resources for non-Hodgkin lymphoma What’s new in non-Hodgkin lymphoma research and treatment? Research ... non-Hodgkin lymphoma is focused on looking at new and better ways to treat this disease. Chemotherapy ...


The Role of Chemotherapy in Hodgkin's Lymphoma  

PubMed Central

The development of curative chemotherapy regimens for the treatment of Hodgkin’s lymphoma is one of the true success stories in oncology. Most patients diagnosed with Hodgkin’s lymphoma today can be cured. The major task remaining before us is curing as many patients as possible with their initial therapeutic approach while minimizing the acute toxicities and limiting the lifetime risks of important secondary events such as cardiovascular complications and secondary malignancies. In the 40 years since DeVita and colleagues developed the MOPP (Mechlorethamine, Vincristine, Procarbazine, Prednisone) chemotherapy regimen, we have learned a great deal about risk stratification to minimize treatment-related toxicity. Positron-emission tomography may further assist us in reducing radiation treatment without compromising cures. This review will discuss the development of the chemotherapy regimens used in the management of early and advanced stage Hodgkin’s lymphoma and the advantages and disadvantages of their use in combination with radiation therapy.

Seam, Pamela; Janik, John E.; Longo, Dan L.; DeVita, Vincent T.



RAND Classics  

NSDL National Science Digital Library

The RAND Corporation has recently added selections from the writings of Albert Wohlstetter to its well known RAND Classics site. Wohlstetter "was a mathematical logician and senior staff member at RAND in the 1950s and 1960s.... His studies led to the 'second-strike' and 'Fail-Safe' concepts for deterring nuclear war. These and other methods reduced the probability of accidental war." At present, 24 selections are available, ranging from 1952 to 1970. More are forthcoming. In addition to Wohlstetter's writings, RAND Classics contains eleven of Paul Baran et al's twelve volume On Distributed Communications (1968), RAND's A Million Random Digits with 100,000 Normal Deviates (1955), and Toward an Ethics and Etiquette for Electronic Mail (1985), by Norman Z. Shapiro and Robert H. Anderson.



Constitutive overexpression of a novel 21 kDa protein by Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphomas  

PubMed Central

Background CD30, a 120 kDa surface phosphorylated protein is a member of tumour necrosis/nerve growth factor receptor (TNF/NGFR) family and constitutively expressed by Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) and the neoplastic cells of Anaplastic Large Cell Lymphoma (ALCL). A disease-specific protein marker is yet to be identified in Hodgkin lymphoma cells. In order to define HL-specific biomarkers, novel murine monoclonal antibodies were developed in our laboratory. Results Murine monoclonal antibodies (mabs) were raised against the B3 sub clone of HL-derived cell line KM-H2. Two of these mabs (clone R23.1 mab and clone R24.1 mab) are IgG1 class antibodies that recognize a 21 kDa protein present at the cell membrane and in the cytoplasm in HL-derived cell lines. Clone R24.1 mab recognizes a formalin-resistant epitope and labels HRS cells in tissue samples from patients with HL of the classical type, ALCL, and subsets of T and B cell aggressive Non-Hodgkin Lymphomas (NHL). The antigen recognized by the clone R23.1 mab and clone R24.1 mab does not share epitopes with CD30 cluster regions A, B, or C, and, unlike CD30, is not expressed by phytohemagglutinin (PHA) activated T cells. Conclusion The 21 kDa protein detected by clone R23.1 and clone R24.1 mabs is a novel membrane-associated protein that may be a potential marker for the diagnosis and targeted therapy of HL and aggressive T and B cell NHL.

Zhou, Minglong; Fadlelmola, Faisal M; Cohn, Jason B; Skinnider, Brian; Gascoyne, Randy D; Banerjee, Diponkar



Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma  

PubMed Central

In classical Hodgkin’s lymphoma (HL) the malignant mononuclear Hodgkin (H) and multinuclear, diagnostic Reed-Sternberg (RS) cells are rare and generally make up <3% of the total cellular mass of the affected lymph nodes. During recent years, the introduction of laser micro-dissection techniques at the single cell level has substantially improved our understanding of the molecular pathogenesis of HL. Gene expression profiling, comparative genomic hybridization analysis, micro-RNA expression profiling and viral oncogene sequencing have deepened our knowledge of numerous facets of H- and RS-cell gene expression deregulation. The question remains whether disturbed signaling pathways and deregulated transcription factors are at the origin of refractory/relapsing Hodgkin’s lymphoma or whether these hallmarks are at least partially related to another major factor. We recently showed that the 3D nuclear organization of telomeres and chromosomes marked the transition from H- to RS-cells in HL cell lines. This transition is associated with progression of telomere dysfunction, shelterin disruption and progression of complex chromosomal rearrangements. We reported analogous findings in refractory/relapsing HL and identified the shelterin proteins TRF1, TRF2 and POT1 as targets of the LMP1 oncogene in post-germinal center B-cells. Here we summarize our findings, including data not previously published, and propose a model in which progressive disruption of nuclear integrity, a form of genomic instability, is the key-player in refractory/relapsing HL. Therapeutic approaches should take these findings into account.

Knecht, Hans; Righolt, Christiaan; Mai, Sabine



Chinese Cooking.  

ERIC Educational Resources Information Center

This unit, intended for secondary level students, is a general introduction to Chinese cooking. It is meant to inform students about the origins of Chinese cooking styles in their various regional manifestations, and it can be used to discuss how and why different cultures develop different styles of cooking. The first part of the unit, adapted…

Kane, Tony


Primary multifocal osseous Hodgkin's lymphoma  

PubMed Central

Background Hodgkin's disease (HD) most commonly presents with progressive painless enlargement of peripheral lymph nodes, especially around the cervical region. A few children have systemic symptoms and weight loss. At the time of diagnosis, osseous involvement is uncommon Case presentation A case is described of Primary Multifocal Osseous Hodgkin's Lymphoma in a seven-year-old boy. He presented with a painful swelling in the sternum, and further investigations revealed deposits in his L1 vertebra, the left sacro-iliac joint and the right acetabulum. Conclusion The clinical, radiological and histological features of this disease can mimic other medical conditions, including Tuberculosis, making the diagnosis difficult and often leading to delays in treatment. This is a very rare condition and we believe this to be the youngest reported case in the literature.

Langley, Clare R; Garrett, Simon JW; Urand, Jill; Kohler, Janice; Clarke, Nick MP



Simultaneous presentation of relapsing Hodgkin's disease and treatment-related non-Hodgkin's lymphoma  

SciTech Connect

A 55-year-old white man was diagnosed in 1975 with Hodgkin's disease stage IIA, mixed cellularity. He was treated with 4,500 rads to an inverted-Y field followed by six cycles of MOPP and remained in complete remission. In 1983 a right axillary lymph node biopsy showed recurrent Hodgkin's disease, mixed cellularity. While receiving his initial chemotherapy he developed persistent epigastric distress. Endoscopic gastric biopsy demonstrated a diffuse large-cell non-Hodgkin's lymphoma. Surface marker studies confirmed the separate identity of these two malignant lymphoproliferative processes. This represents the first reported simultaneous occurrence of relapsing Hodgkin's disease with treatment-related non-Hodgkin's lymphoma.

Perri, R.T.; Allen, J.I.; Oken, M.M.; Limas, C.; Kay, N.E.



Salvage Therapy in Hodgkin's Lymphoma  

Microsoft Academic Search

Hodgkin's disease is a rare malignancy that affects ap- proximately 7,500 patients per year in the U.S., leading to anestimated1,400deaths.Therelapserateforthisdisease varies from around 5% for early-stage disease to 35% for patients with advanced disease. Patients who relapse after chemotherapy have about a 20% cure rate with conven- tional salvage chemotherapy. Two randomized phase III studies have shown an improved failure-free



Treatment of Pediatric Hodgkin Lymphoma  

Microsoft Academic Search

Opinion statement  We are increasingly successful in the treatment of Hodgkin lymphoma. Current risk adapted trials seek to maintain the excellent\\u000a efficacy of older therapies, while simultaneously limiting their late toxicities. Current management of early stage\\/favorable\\u000a disease involves the use of two to four cycles of tailored chemotherapy, often followed by low-dose, involved field radiation.\\u000a Those with intermediate and advanced stage

Michael R. Olson; Sarah S. Donaldson



Staging laparotomy in Hodgkin's disease.  

PubMed Central

Staging laparotomy (multiple liver and lymph node biopsies and splenectomy) was performed at the North Carolina Baptist Hospital in 123 patients with Hodgkin's disease. There were no deaths. Wound, pulmonary, intra-abdominal or urinary tract complications developed in 17 patients. Of those complications, one case each of pelvic abscess, subphrenic abscess, small bowel obstruction, staphylococcal peritonitis and subphrenic hematoma required a major intra-abdominal operation. The patients were classified on the basis of histopathology; nodular sclerosis--40, mixed cellularity--44, lymphocyte predominant--24, lymphocyte depleted--13, and undetermined--2. The pathological stage following laparotomy was unchanged from the clinical stage in 62%, reduced in 15%, and advanced in 23%. Subsequent therapy, therefore, was altered in 38% of the patients. Lymphangiography, done in 108 patients, showed lymph node involvement in 46 patients and no involvement in 62 patients. Of those lymphangiographic findings, 79% were confirmed histopathologically, 19% were falsely positive, and 1.8% were falsely negative. There were positive findings of Hodgkin's disease in the spleen in 42% of patients. The staging laparotomy continues to be a valuable tool in the staging and treatment of Hodgkin's disease.

Sterchi, J M; Myers, R T



Mediastinal Choriocarcinoma Masquerading as Relapsed Hodgkin Lymphoma  

PubMed Central

Primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy. We describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for Hodgkin lymphoma (HL). A 25-year-old man with classic HL, nodular sclerosis subtype, underwent treatment with splenectomy followed by radiation therapy. Unfortunately, his disease relapsed with a paraspinal mass, and he was subsequently treated with MOPP (mechlorethamine, Oncovin, procarbazine, and prednisone) alternating with ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine). He achieved a complete remission after 6 cycles. Ten years after treatment, the patient presented with a persistent cough, haemoptysis, right supraclavicular lymphadenopathy, and weight loss. His chest X-ray showed opacification of the lower right hemithorax with a widened mediastinum. Given unresponsiveness to several antibiotics and lack of evidence for lung volume loss, there were concerns over lung infiltration with relapsed lymphoma. Transbronchial fine needle aspiration biopsy suggested recurrence of his HL. MOPP alternating with ABVD was again given. Due to disease progression, brachytherapy as well as a cocktail of dexamethasone, cytarabine, and cisplatin were also tried. However, on a subsequent excisional lymph node biopsy, it turned out that the tumour was in fact choriocarcinoma and not relapsed HL. Unfortunately, despite aggressive therapy, the patient's disease rapidly progressed, and he died within 2 weeks.

Lam, Selay; Rizkalla, Kamilia; Hsia, Cyrus C.



Favorable early-stage Hodgkin lymphoma.  


The category of favorable early-stage Hodgkin lymphoma (HL) includes patients with Ann Arbor stages I or II disease with no bulky disease or B symptoms. The precise definition of favorable versus unfavorable early-stage disease may vary among American and European cooperative groups. The overall 10-year survival rate of patients with favorable early-stage HL exceeds 90%. Indeed, effective treatments for this group of patients have been available for more than 4 decades. However, treatment strategies have radically changed over the past 15 years and focus now on maintaining the high cure rate while reducing the risk of treatment-related long-term morbidity. The optimal treatment is still evolving, and more recently, reduction in the total amount of chemotherapy and in radiation field and dose has shown excellent results. Combined modality therapy is the preferred treatment for patients with classical favorable early-stage HL (nodular sclerosis or mixed cellularity histology). Patients with early-stage lymphocyte predominance HL are highly curable using involved-field radiation therapy (IFRT) alone and do not require chemotherapy. Classical favorable HL is also curable with radiotherapy alone or with chemotherapy alone, but larger fields and higher-dose radiation or longer chemotherapy is required compared with combined modality. The freedom from treatment failure rate is significantly better with a combination of short chemotherapy and IFRT than with either chemotherapy or radiotherapy alone. Although combined modality is the standard preferred treatment for favorable disease, radiation therapy alone or chemotherapy alone could be considered under special circumstances or as part of an investigational protocol. PMID:16507270

Yahalom, Joachim



Paraneoplastic cerebellar degeneration associated with Hodgkin's disease  

Microsoft Academic Search

A case of paraneoplastic cerebellar degeneration (PCD) associated with Hodgkin's disease is presented. The features that make this case particularly interesting are the simultaneous occurrence of PCD with a relapse of Hodgkin's disease, which has been present for 17 years, and the arrested progression of cerebellar dysfunction after a subacute onset. Cerebellar atrophy was revealed by computed tomography and magnetic

K. Wessel; H. C. Diener; G. Schroth; J. Dichgans



The Pathology and Nomenclature of Hodgkin's Disease  

Microsoft Academic Search

Summary The diverse morphologic expressions of Hodgkin's disease have been reviewed and compared to the numerous histologie terms in the literature and the author's recently proposed histologie types. The relationship of the histologie findings to the clinical stages and survival has also been analyzed. The histologie ex pressions of the Hodgkin's disease process appear to be reparable into the following



Classics Unveiled  

NSDL National Science Digital Library

Classics Unveiled was developed by Neil Jenkins, Sumair Mirza and Jason Tang as a way to teach the web-browsing public about the various aspects of the ancient world, ranging from the massive world of Greek and Roman mythology, Roman history, Roman culture, and the Latin language and its pervasive influence on English. The site is divided into four primary areas, and visitors may opt to browse through any of them and their accompanying features, which include primary extended essays and informative games and quizzes. In Rome Exposed for example, users will learn about Roman residences, entertainment, attire, cuisine, and several other aspects of Roman culture and mores. In MythNET visitors can learn about the twelve Olympian gods, read about the Trojan War, and explore genealogical charts that trace the various relationships between the pantheon of Rome and Greece.

Jenkins, Neil; Mirza, Sumair; Tang, Jason


Prevalence of human endogenous retroviral element associates with Hodgkin's lymphoma incidence rates?  

PubMed Central

Human endogenous retrovirus-H (HERV-H) is implicated in leukaemias and lymphomas, but the precise molecular mechanism underlying HERV-mediated carcinogenesis remains unknown. We determined the prevalence of HERV-H in a cross-section of the Singapore population and explored the relationship between HERV-H positivity and incidence rates for Hodgkin's lymphoma in three major ethnic groups of Singapore. We observed that Malays were 1.11 times likely (95% CI=1.05–1.17; P<0.01), and Indians 1.12 times likely (95% CI=1.07–1.18; P<0.01) to be HERV-H positive when compared to Chinese. Interestingly, the incidence rates of Hodgkin's lymphoma for the three races positively correlated to the respective prevalence rate for HERV-H positivity (r=0.9921 for male; r=0.9801 for female), suggesting that viral inheritance in human may predispose certain racial origin unfavourably to malignancy.

Woo, Wee Hong; Shen, Liang; Leong, Sai Mun; Koay, Evelyn Siew-Chuan



Changing Patterns in the Clinical Pathological Features of Hodgkin Lymphoma: A Report from Debrecen, Hungary  

PubMed Central

Introduction. Hodgkin lymphoma shows a well-known geographic pattern, but temporal changes have been found recently as well. Patients and Methods. 439 Hodgkin lymphoma patients' clinicopathological and treatment data were processed in calendar periods of approximately ten years. The patients were treated at our department from 1980 until the end of 2008. Results. The first period (1980–89) contained 177 patients, the second (1990–99) 147, and the third (2000–08) 115 Hodgkin lymphoma patients. The mean age of the patients was 40.1, 35.9, and 36.8 years in order. The male/female ratio: 1.42, 1.45, 1.05 in order. Contrary-wise a unimodal age group pattern could have been seen with an incidence peak between 30 and 39 in the past decades. The incidence of classical mixed cellularity histological subtype is decreasing (43.7%, 58.23%, 42.6%, P = 0.0098 (it is only significant in the second period)); classical nodular sclerosis shows an increasing tendency (25%, 27.32%, 34.78%, P = 0.1734). The first incidence peak is predominantly created by classical nodular sclerosis, meanwhile the second peak by classical mixed cellularity. The number of early-stage patients (59.12%) is beyond the advanced stage (40%) in the last decade. Meanwhile, the number of second-stage patients was increasing (25.8%, 26.35%, 49.56%??P < 0.0001) and of patients in third stage was decreasing (53.4 %, 50.67%, 20%??P < 0.0001). The 5- and 10-year overall survival data were progressing: 59.7 %, 77.4 %, and 90.5 % and 44.1 %, 70.6 % and 90.5 % (expected survival) in the last decade. Conclusions. Changes can be explained by the altered nature of Hodgkin lymphoma, the changes in socioeconomic status and the development of diagnostic and therapy methods.

Miltenyi, Zsofia; Simon, Zsofia; Payer, Edit; Varoczy, Laszlo; Gergely, Lajos; Jona, Adam; Illes, Arpad



Hodgkin's Disease: Treatment and Prognosis  

PubMed Central

The prognosis of Hodgkin's disease (HD) has improved impressively in the past decade. Presently, no stage of disease is beyond cure or expectancy of a long disease-free survival. The extent of disease involvement governs the choice of therapy. The treatment of choice for localized disease is irradiation, although the techniques used vary considerably among different centres. Combination chemotherapy is recommended for stages 3B and 4. The management of stage 3A and some high-risk subsets of HD remains controversial. In specific situations, combined treatments are indicated. Therapy associated complications, immediate or delayed, deserve greater attention. Ironically, their impact upon the improved survivors might be morbid and devastating.

Ing, V. W.



The tangible and intangible value of the Suzhou Classical Gardens  

Microsoft Academic Search

The comment of United Nations Educational, Scientific and Cultural Organization to the Classical Gardens of Suzhou is that Classical Chinese garden design, which seeks to recreate natural landscapes in miniature, is nowhere better illustrated than in the nine gardens in the historic urban of Suzhou. They are generally acknowledged to be masterpieces of the genre. Dating from the 11th-19th century,

YI Xueling


Vaccinology of classical swine fever: from lab to field  

Microsoft Academic Search

There are two types of classical swine fever vaccines available: the classical live and the recently developed E2 subunit vaccines. The live Chinese strain vaccine is the most widely used. After a single vaccination, it confers solid immunity within a few days that appears to persist lifelong. The E2 subunit vaccine induces immunity from approximately 10¿14 days after a single

Oirschot van J. T



Vaccinology of classical swine fever: from lab to field  

Microsoft Academic Search

There are two types of classical swine fever vaccines available: the classical live and the recently developed E2 subunit vaccines. The live Chinese strain vaccine is the most widely used. After a single vaccination, it confers solid immunity within a few days that appears to persist lifelong. The E2 subunit vaccine induces immunity from approximately 10–14 days after a single

J. T van Oirschot



[News in hodgkin lymphoma therapy].  


Hodgkin lymphoma is a well-known clinico-pathological entity with a stable incidence among time accounting for 1200 new cases each year in France. The disease is one of the most curable cancer and occurs often in young patients with a median age at 33 years, the major clinical symptoms are lymph nodes mostly above the diaphragm (mediastinal and supra-clavicular). The diagnosis should be suggested with non-specific symptoms such as fever, night sweats, pruritus, weight-loss, lymph node, cough.. leading to prescribe routine exams like blood test with leucocyte count, erythrocyte sedimentation rate and chest Xray. Treatments always include chemotherapy and radiotherapy in localized disease and at a low dose only in involved fields. The usually good prognostic of Hodgkin lymphoma may not let us forget that there are still deaths in patients with refractory or early relapse of the disease. There is still an unmet need is these patients and the search for new drugs is essential. PMID:24445772

Brice, Pauline



Telemedical database of Hodgkin's disease.  


The creation of a complex telemedical system oriented towards childhood Hodgkin's disease has been undertaken at the Department of Bioinformatics and Telemedicine of the Jagiellonian University Medical College in cooperation with the Department of Oncology and Pediatric Hematology of the Polish-American Institute of Pediatrics, JU MC. Data collecting, data processing and data transmission is aimed to aid and/or supervise surgical and drug treatment. The Tele-Database of Childhood Hodgkin's Disease (TDCHD) is not a simple Internet database project. A few hundred data items are presented in each patient's record, covering the complete medical treatment period. Efficient management and proper data protection are necessary for a medical database. Therefore, the interface for entering data has been divided into several parts. Each part is subjected to separate editing and transfer. A double-layer debugging system has been applied in the program: the first pass occurs on the client side (programmed in JavaScript and XML), the second - on the server side (programmed in PHP). Strict authorization is requested for all participants. Clinical data collected according to management standards and information governance (data quality, security and confidentiality) is organized in a way that facilitates practical and scientific use. PMID:15718594

Walecki, Piotr; Sarapata, Krzysztof; Laso?, Wojciech; Pyrczak, Wies?aw; Roterman-Konieczna, Irena; Balwierz, Walentyna



Profiling of Hodgkin's Lymphoma Cell Line L1236 and Germinal Center B Cells: Identification of Hodgkin's Lymphoma-specific Genes  

PubMed Central

The malignant cells of classical Hodgkin’s lymphoma (cHL), Hodgkin and Reed-Sternberg (HRS) cells, appear to be derived from germinal center (GC) B cells in most cases of the disease. Apart from recent findings of constitutive activation of some transcription factors and autocrine stimulation by cytokine receptors, the mechanisms of malignant transformation in cHL still remain poorly understood. We performed a large scale gene expression study using serial analysis of gene expression (SAGE), comparing the cHL cell line L1236 and human GC B cells. Semiquantitative RT-PCR was used to confirm results from the SAGE and to analyze gene expression in 3 additional cHL cell lines. To investigate expression of some genes in cHL cases, we applied RT-PCR on microdissected HRS cells. In total, 464 genes showed a change in expression level of 5-fold or higher. For 12 genes (out of 177) identified as upregulated in L1236 cells, RT-PCR confirmed the SAGE results and also showed elevated expression in 3 other cHL cell lines. For 3 of the upregulated genes, expression by HRS cells in the tissue also was confirmed. Several of the differentially expressed genes may play a role in the pathogenesis of cHL because they represent potential oncogenes, such as rhoC, L-myc, and PTP4A, or transcription factors, such as ATF-5, ATBF1, and p21SNFT. The genes that showed significantly deregulated expression in HRS cells should be helpful not only for the identification of genes involved in the pathogenesis of cHL but also for discovering potential prognostic markers or therapeutic targets.

Schwering, Ines; Brauninger, Andreas; Distler, Verena; Jesdinsky, Julia; Diehl, Volker; Hansmann, Martin-Leo; Rajewsky, Klaus; Kuppers, Ralf



Memristor, Hodgkin-Huxley, and edge of chaos.  


From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm's law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of 'pinched' hysteresis loops in the v-i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin-Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin-Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling 'Goldilocks zone', dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors. PMID:23999613

Chua, Leon



Shedding light on UVR and Hodgkin lymphoma.  


In this issue of Blood, Monnereau and colleagues pool 4 retrospective (case-control), observational epidemiologic studies to demonstrate an inverse association between UV radiation (UVR) exposure and risk of developing Hodgkin lymphoma (HL). PMID:24235128

Morton, Lindsay M; Freedman, D Michal



Treatment Options for Childhood Hodgkin Lymphoma  


... Drugs Approved for Hodgkin Lymphoma for more information. Radiation therapy Radiation therapy is a cancer treatment that uses ... available from the NCI Web site . Proton beam radiation therapy Proton-beam therapy is a type of high- ...


General Information about Adult Hodgkin Lymphoma  


... of body tissues called a sonogram . There are three ways that cancer spreads in the body. Cancer ... term health of patients treated for Hodgkin lymphoma. Three types of standard treatment are used: Chemotherapy Chemotherapy ...


Adult Non-Hodgkin Lymphoma (PDQ): Treatment  


... trials is available from the NCI Web site . Aggressive, Stage I and Contiguous Stage II Adult Non- ... trials is available from the NCI Web site . Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin ...


Treatment Options for Non-Hodgkin Lymphoma  


... trials is available from the NCI Web site . Aggressive, Stage I and Contiguous Stage II Adult Non- ... trials is available from the NCI Web site . Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin ...


Hodgkin Lymphoma and Nephrotic Syndrome in Childhood  

Microsoft Academic Search

An association between nephrotic syndrome and extrarenal neoplasia was described for the first time in 1922. Since then a\\u000a large number of cases have been published, few of them describing the link between Hodgkin disease (HD) and nephrotic syndrome\\u000a (NS). It shows that the incidence of nephrotic syndrome in Hodgkin lymphoma is less than 1%. Till date, to the best

Piero Farruggia; Antonino Trizzino; Silvio Maringhini; Antonella Grigoli; Chiara Sapia; Mariella D’Alessandro; Serena Tropia; Paolo D’Angelo



Population Encoding With Hodgkin-Huxley Neurons  

PubMed Central

The recovery of (weak) stimuli encoded with a population of Hodgkin–Huxley neurons is investigated. In the absence of a stimulus, the Hodgkin–Huxley neurons are assumed to be tonically spiking. The methodology employed calls for 1) finding an input–output (I/O) equivalent description of the Hodgkin–Huxley neuron and 2) devising a recovery algorithm for stimuli encoded with the I/O equivalent neuron(s). A Hodgkin–Huxley neuron with multiplicative coupling is I/O equivalent with an Integrate-and-Fire neuron with a variable threshold sequence. For bandlimited stimuli a perfect recovery of the stimulus can be achieved provided that a Nyquist-type rate condition is satisfied. A Hodgkin–Huxley neuron with additive coupling and deterministic conductances is first-order I/O equivalent with a Project-Integrate-and-Fire neuron that integrates a projection of the stimulus on the phase response curve. The stimulus recovery is formulated as a spline interpolation problem in the space of finite length bounded energy signals. A Hodgkin–Huxley neuron with additive coupling and stochastic conductances is shown to be first-order I/O equivalent with a Project-Integrate-and-Fire neuron with random thresholds. For stimuli modeled as elements of Sobolev spaces the reconstruction algorithm minimizes a regularized quadratic optimality criterion. Finally, all previous recovery results of stimuli encoded with Hodgkin–Huxley neurons with multiplicative and additive coupling, and deterministic and stochastic conductances are extended to stimuli encoded with a population of Hodgkin–Huxley neurons.

Lazar, Aurel A.



CD40 expression in Hodgkin's disease.  

PubMed Central

CD40 is a transmembrane protein that belongs to a superfamily of proteins related to nerve growth factor receptor. CD40 is expressed on B cells and some B cell malignancies. It appears to be involved in B cell proliferation and the prevention of apoptosis in germinal center cells, which is accompanied by expression of bcl-2. Its expression is up-regulated by the EBV protein latent membrane protein-1 and cytokines interleukin-4 and interferon-gamma. The expression of CD40 in 37 cases of Hodgkin's disease and 23 cases of non-Hodgkin's lymphoma (11 T cell lymphomas and 12 B cell lymphomas) was examined by paraffin section immunohistochemistry using the BB-20 monoclonal antibody. In 26 of 37 cases of Hodgkin's disease the Reed-Sternberg cells showed strong membrane or cytoplasmic expression of CD40. Only 3 of 23 non-Hodgkin's lymphomas showed any expression of CD40 and then only weakly. There was no correlation between expression of bcl-2 or latent membrane protein-1 with CD40 expression. These results show that there is probable hyperexpression of CD40 in Hodgkin's disease and suggest that dysregulation of CD40 expression may play a role in the pathogenesis of Hodgkin's disease. Images Figure 1

O'Grady, J. T.; Stewart, S.; Lowrey, J.; Howie, S. E.; Krajewski, A. S.



Chinese Connections  

ERIC Educational Resources Information Center

When L. Brooks Patterson, the executive of Oakland County, Michigan, publicly called for the county to become the first in America to teach Mandarin Chinese in every public school district, the Oxford Community Schools responded immediately. Over the past four years, the school district of 5,030 students in southeastern Michigan has elevated the…

Skilling, William C.



[Non-Hodgkin's lymphoma in a patient after many years of remission of Hodgkin's disease].  


Authors present 38-years old woman with 11-years lasting complete remission of Hodgkin's disease who was recognized to have non-Hodgkin's lymphoma of the base of the tongue and also of stomach three months later. After polychemotherapy complete remission was achieved. PMID:8525778

Ka?mierczak, M; Komarnicki, M; Kroll, R



Immunoglobulins in Familial Hodgkin’s Disease and Immunodeficiency in Newfoundland  

Microsoft Academic Search

A familial aggregate of 7 cases of Hodgkin’s disease, 3 of common variable immunodeficiency, 8 of other lymphoreticular malignancies, and 4 of embryonic tumours is being studied in a multidiscipline fashion to search for clues to aetiology. Part of the investigation was to examine immunoglobulin concentrations in the whole population, both in family members and in other members of the

L. S. Salimonu; D. G. Bryant; S. K. Buehler; R. K. Chandra; J. Crumley; W. H. Marshall



Chinese Geography through Chinese Cuisine  

ERIC Educational Resources Information Center

China has the world's largest population, now over 1.3 billion, but its land area (much of it high mountains or desert) is about the same as that of the United States, which has less than one-fourth as many people. So Chinese farmers have learned to use every inch of their fertile land intensively. Pressure on the land has required extremely…

Lipman, Jonathan



What Are the Key Statistics for Hodgkin Disease?  


... factors for Hodgkin disease? What are the key statistics about Hodgkin disease? The American Cancer Society’s estimates ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...


Tracheoesophageal fistula as the presenting manifestation of Hodgkin's lymphoma.  

PubMed Central

We present a patient with tracheoesophageal fistula as the initial manifestation of Hodgkin's disease with oesophageal involvement. To our knowledge, this has not been previously reported. The diagnosis of Hodgkin's lymphoma was made at autopsy. Images Figure 1

Alba, D.; Lobato, S. D.; Alvarez-Sala, R.; Villasante, C.; Echevarria, C.



What's New in Hodgkin Disease Research and Treatment?  


... Next Topic Additional resources for Hodgkin disease What’s new in Hodgkin disease research and treatment? Important research ... yet still cure as many patients as possible. New chemotherapy combinations of as many as 10 different ...


Omental caking in Hodgkin's disease. Computed tomography findings.  


Neoplastic infiltration of the greater omentum is most commonly caused by metastatic ovarian, gastric, colonic, or pancreatic carcinoma. Because the omentum lacks lymphoid elements, lymphomatous infiltration is uncommon. To date, omental involvement by lymphoma has been reported exclusively in patients with non-Hodgkin's lymphomas. In this report, the computed tomography findings of omental caking caused by Hodgkin's lymphoma are described. Although rare, both Hodgkin's and non-Hodgkin's lymphomas should be included in the differential diagnosis of omental caking. PMID:8959363

Jacobs, J E; Salhany, K E; Fox, K R; Birnbaum, B A



Disparate survival and risk of secondary non-Hodgkin lymphoma in histologic subtypes of Hodgkin lymphoma: a population-based study.  


Abstract We compared survival outcomes and rates of secondary non-Hodgkin lymphoma (NHL) in 28 323 patients with nodular lymphocyte predominant (NLPHL) and classical Hodgkin lymphoma (HL) from the Surveillance, Epidemiology and End Results database, diagnosed between 1995 and 2010. In a multivariate analysis NLPHL demonstrated a significantly better relative survival (5-year risk of lymphoma-related death 5.7%, hazard ratio [HR] 0.46, p < 0.0001) than the reference nodular sclerosis (NSHL) subtype (5-year risk 12.7%). Lymphocyte-rich classical HL had outcomes comparable to NSHL (5-year risk 14.3%, HR 0.84, p = 0.11). Exceptionally poor outcomes were observed in lymphocyte depleted HL (5-year risk 48.8%, HR 2.26, p < 0.0001). The risk of secondary NHL was increased in NLPHL (HR 2.81, p < 0.001) and lymphocyte-rich classical HL (HR 2.27, p = 0.002), but not in other subtypes compared with NSHL. In conclusion, the histologic classification retains a significant prognostic value in HL and the disparities between the subtypes warrant customized treatment and surveillance strategies. PMID:24067135

Ali, Shihab; Olszewski, Adam J



Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review  

PubMed Central

Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persistent cough, pruritus, and ten-pound weight lost during this time. The CBC revealed hemoglobin of 5.9?gm/dL, and direct Coomb's test detected multiple nonspecific antibodies consistent with the diagnosis of AIHA. Chest, abdomen, and pelvic CT scan showed mediastinal lymphadenopathy and splenomegaly. Lymph node biopsy revealed classic LRHL. AIHA resolved after completion of the first cycle of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD); after six cycles, he went into complete remission. Although infrequent, AIHA can be responsible for the presenting symptoms of HL.

Hurtado-Cordovi, Jorge M.; Verma, Vaibhav; Gotlieb, Vladimir; Frieri, Marianne



Primary Hodgkin lymphoma of the central nervous system.  


Primary involvement of the central nervous system by Hodgkin lymphoma is rare; most cases represent metastases. We report a primary Hodgkin lymphoma presenting in the cerebellum of a 77-year-old man and review the literature on primary Hodgkin lymphoma of the central nervous system. PMID:24589557

Sharaf, Nematullah; Lobo, Bjorn; Lee, Joung; Prayson, Richard A



Paraneoplastic neurological syndromes in Hodgkin and non-Hodgkin lymphomas.  


Paraneoplastic neurological syndromes (PNSs) rarely associate with Hodgkin lymphoma (HL) and non-HLs (NHLs). Except for paraneoplastic cerebellar degeneration (PCD) in HL and dermato/ polymyositis in both HL and NHL, other PNSs are uncommon and have only been reported as isolated case reports or short series. There are several important differences in PNSs when occurring in association with HL and NHL compared with those associated with solid tumors. First, some PNSs such as sensory neuronopathy or Lambert-Eaton myasthenic syndrome rarely occur in lymphomas, whereas others, such as granulomatous angiitis, are only described in HL. Second, onconeural antibodies are absent in most PNSs associated with lymphomas with the exceptions of Tr (?/notch-like epidermal growth factor-related receptor) in PCD and mGluR5 in limbic encephalitis (LE). The antigens recognized by these antibodies are not expressed in lymphoma cells, suggesting the tumor itself does not trigger the PNS. Third, unlike patients with solid tumors in patients with lymphoma, the PNSs often develops at advanced stages of the disease. Furthermore, the type and frequency of PNSs are different between HL and NHL; whereas LE and PCD occur almost exclusively in patients with HL, sensorimotor neuropathies and dermatomyositis are more frequent in NHL. PMID:24705493

Graus, Francesc; Ariño, Helena; Dalmau, Josep



Chinese Culture and Leadership.  

ERIC Educational Resources Information Center

Describes essential characteristics of Chinese philosophical tradition; Discusses Western perspectives on value leadership in education, particularly moral leadership. Discuses moral leadership from a Chinese philosophical perspective, especially Confucianism. Draws implications for using Chinese cultural and philosophical traditions to develop…

Wong, Kam-Cheung



Intrinsic inhibition of transcription factor E2A by HLH proteins ABF1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma  

Microsoft Academic Search

B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell–specific transcription factor

Martin Janz; Franziska Hummel; Michael Hummel; Brigitte Wollert-Wulf; Simone Lusatis; Ioannis Anagnostopoulos; Andreas Lietz; Mikael Sigvardsson; Franziska Jundt; Korinna Jöhrens; Kurt Bommert; Harald Stein; Bernd Dörken; Stephan Mathas



Postradiation sarcoma of bone in Hodgkin disease.  


We report 16 cases seen in the Memorial Sloan-Kettering Cancer Center (MSKCC) during the past 50 years. These patients had been treated with external radiation for Hodgkin disease and had developed sarcomas in the field 4-31 years after the diagnosis of Hodgkin disease. Most of the tumors (12 of 16) occurred in the chest wall. There were three tumors of the pelvis and an unusual osteosarcoma of the femur following treatment for a primary Hodgkin disease of the femur. The tumors were predominantly osteosarcomas (9). In addition, there were five malignant fibrous histiocytomas, one fibrosarcoma, and one chondrosarcoma. Prognosis was poor; the mean survival was 12 months. Survival of patients with other primary cancers who developed radiation sarcomas was not significantly different from that of patients with Hodgkin disease. Hodgkin disease is now the most common tumor among radiation-induced sarcomas in previously normal bone and has surpassed breast cancer, which was previously the most common original tumor. PMID:2827314

Smith, J



Hodgkin’s disease: A disorder of dysregulated cellular cross-talk  

Microsoft Academic Search

Hodgkin’s disease (HD) is a peculiar type of human malignant lymphoma characterized by a very low frequency of tumor cells,\\u000a the so called Hodgkin and Reed-Sternberg (H-RS) cells, embedded in a hyperplastic background of non-neoplastic (reactive)\\u000a cells recruited and activated by H-RS cells-derived cytokines. H-RS cells can be functionally regarded as antigen-presenting\\u000a cells (APC) able to elicit an intense, but

Antonio Pinto; Valter Gattei I; Vittorina Zagonel; Donatella Aldinucci I; Massimo Degan; Angela De Iuliis; Francesca Maria Rossi; Francesca Tassan Mazzocco; Cristiana Godeas I; Maurizio Rupolo; Dalisa Poletto; Annunziata Gloghini; Antonino Carbone; Hans-Jtirgen Gruss



Prognostic Factors in Hodgkin Lymphoma  

PubMed Central

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise.

Cuccaro, Annarosa; Bartolomei, Francesca; Cupelli, Elisa; Galli, Eugenio; Giachelia, Manuela; Hohaus, Stefan



Hodgkin's disease associated with sarcoidosis: case report.  


Coexistence of true systemic sarcoidosis and Hodgkin's disease has been reported as a very exceptional occurrence. In this paper a case observed at the Institute of Radiology of Florence is described of which the most interesting features were 1) sarcoidosis appeared 5 years earlier than Hodgkin's disease; 2) at staging lymphography the paraortic nodes appeared extensively enlarged and showed multiple filling defects; 3) at laparotomy the nodes removed were histologically affected by sarcoidosis only; 4) multiple foci of sarcoidosis were found also in the spleen and liver; 5) this feature led us to refrain from irradiating the abdomen; 6) one year later a further enlargement of paraortic nodes was observed; 7) a second laparotomy revealed Hodgkin's infiltration in the removed nodes; 8) irradiation of the inverted "y" field was followed by complete regression of the nodes and the patient is alive and well 2.5 years after the relapse. PMID:7245354

Ponticelli, P; Arganini, L; Cionini, L



Ptosis: a rare presentation of Hodgkin lymphoma.  


Lymphomas predominantly affect the lymph nodes but can present at unusual sites, which are termed as extranodal lymphomas. Involvement of the ocular adnexa is an extremely uncommon occurrence, which is usually seen in patients with non-Hodgkin lymphoma. We report herewith an unusual case of a 5-year-old child with Hodgkin lymphoma and involvement of extraocular muscle leading to ptosis. The child was managed by alternating cycles of cyclophosphamide, vincristine, procarbazine and prednisolone and adriamycin, bleomycin, vinblastine, and dacarbazine. He had complete response to chemotherapy with resolution of ptosis. PMID:23528905

Gupta, Vineeta; Kumar, Mohan; Gupta, Sanjeev K



Hodgkin lymphoma and nephrotic syndrome in childhood.  


An association between nephrotic syndrome and extrarenal neoplasia was described for the first time in 1922. Since then a large number of cases have been published, few of them describing the link between Hodgkin disease (HD) and nephrotic syndrome (NS). It shows that the incidence of nephrotic syndrome in Hodgkin lymphoma is less than 1%. Till date, to the best of author's knowledge, there are about 50 pediatric cases published, no one among Italian children. In the present paper, the authors report 2 cases observed in their department in the 7 yrs period. PMID:20872097

Farruggia, Piero; Trizzino, Antonino; Maringhini, Silvio; Grigoli, Antonella; Sapia, Chiara; D'Alessandro, Mariella; Tropia, Serena; D'Angelo, Paolo



Late complications of Hodgkin's disease management  

SciTech Connect

In the past several decades, Hodgkin's disease has been transformed from a uniformly fatal illness to one that can be treated with the expectation of long-term remission or cure in the majority of patients. Because patients now survive for long periods after curative intervention, various complications have been identified. The spectrum of complications following curative therapy is quite diverse and includes immunologic, cardiovascular, pulmonary, thyroid, and gonadal dysfunction. In addition, second malignant neoplasms in the form of acute leukemia as well as secondary solid tumors have now been documented to occur with increased frequency in patients cured of Hodgkin's disease. 80 references.

Young, R.C.; Bookman, M.A.; Longo, D.L. (Fox Chase Cancer Center, Philadelphia, PA (USA))



Incomplete cytokinesis and re-fusion of small mononucleated Hodgkin cells lead to giant multinucleated Reed-Sternberg cells.  


Multinucleated Reed-Sternberg (RS) cells are pathognomonic for classical Hodgkin lymphoma (HL), and their presence is essential for diagnosis. How these giant tumor cells develop is controversial, however. It has been postulated that RS cells arise from mononucleated Hodgkin cells via endomitosis. Conversely, continuous single-cell tracking of HL cell lines by long-term time-lapse microscopy has identified cell fusion as the main route of RS cell formation. In contrast to growth-induced formation of giant Hodgkin cells, fusion of small mononuclear cells followed by a size increase gives rise to giant RS cells. Of note, fusion of cells originating from the same ancestor, termed re-fusion, is seen nearly exclusively. In the majority of cases, re-fusion of daughter cells is preceded by incomplete cytokinesis, as demonstrated by microtubule bonds among the cells. We confirm at the level of individual tracked cells that giant Hodgkin and RS cells have little proliferative capacity, further supporting small mononuclear Hodgkin cells as the proliferative compartment of the HL tumor clone. In addition, sister cells show a shared propensity for re-fusion, providing evidence of early RS cell fate commitment. Thus, RS cell generation is related neither to cell fusion of unrelated Hodgkin cells nor to endomitosis, but rather is mediated by re-fusion of daughter cells that underwent mitosis. This surprising finding supports the existence of a unique mechanism for the generation of multinuclear RS cells that may have implications beyond HL, given that RS-like cells are frequently observed in several other lymphoproliferative diseases as well. PMID:24302766

Rengstl, Benjamin; Newrzela, Sebastian; Heinrich, Tim; Weiser, Christian; Thalheimer, Frederic B; Schmid, Frederike; Warner, Kathrin; Hartmann, Sylvia; Schroeder, Timm; Küppers, Ralf; Rieger, Michael A; Hansmann, Martin-Leo



Current Strategies and New Approaches in the Treatment of Hodgkin’s Lymphoma  

Microsoft Academic Search

As a result of continuous improvement in therapeutic options and their verification by large multicenter trials, Hodgkin’s lymphoma (HL) has become one of the best curable cancers in adults. Nowadays, about 80–90% of patients in all stages achieve long-term survival. Nevertheless, these good results are threatened by treatment-associated toxicities such as infertility, cardiopulmonary toxicity and secondary malignancies. It is therefore

Michael Fuchs; Volker Diehl; Daniel Re



Immunohistochemical detection of ZAP70 in 341 cases of non-Hodgkin and Hodgkin lymphoma  

Microsoft Academic Search

Using immunohistochemical methods, we evaluated zeta-associated protein (ZAP)-70 expression in 341 cases of non-Hodgkin and Hodgkin lymphoma. In B-cell NHL, ZAP-70 was positive in five of six (83%) precursor B-lymphoblastic lymphoma, 11 of 37 (30%) chronic lymphocytic leukemia\\/small lymphocytic lymphoma (CLL\\/SLL), five of 39 (13%) mantle cell lymphoma, one of 12 (8%) Burkitt lymphoma, and one of 12 (8%) nodal

Joan H Admirand; George Z Rassidakis; Lynne V Abruzzo; Jose R Valbuena; Dan Jones; L Jeffrey Medeiros



Peripancreatic lymph node enlargement in Hodgkin's disease, non-Hodgkin's lymphoma, and pancreatic carcinoma.  


The distribution of enlarged lymph nodes in the upper abdomen and retroperitoneum were classified according to their relationship to the pancreas in 47 patients with non-Hodgkin's lymphoma; in nine patients with Hodgkin's disease; and in 40 patients with pancreatic carcinoma. Four patterns of lymph node enlargement were evident: (1) preaortic retropancreatic lymphadenopathy; (2) pancreaticosplenic lymphadenopathy; (3) isolated celiac and/or portal lymphadenopathy; and (4) diffuse extensive lymphadenopathy. Features differentiating lymphoma from primary pancreatic neoplasm are discussed. PMID:6362986

Costello, P; Duszlak, E J; Kane, R A; Lee, R G; Clouse, M E



SEOM clinical guidelines for the treatment of Hodgkin’s lymphoma  

Microsoft Academic Search

Hodgkin’s lymphoma is a malignant disease with an incidence of 2.2 cases\\/100,000. The main goals of staging are to measure\\u000a the extent of disease and associated prognostic factors. Distinct recommendations were produced for initial work-up, first-line\\u000a therapy of early and advanced stage disease and treatment of relapsed or resistant patients.

Cristina Quero Blanco; Ramón García Arroyo; Mariano Provencio Pulla; Antonio Rueda Domínguez



State-of-the-art Issues in Hodgkin’s Lymphoma Survivorship  

Microsoft Academic Search

The prognosis of Hodgkin’s lymphoma (HL) has markedly improved as management strategies evolved. In the modern era, less than\\u000a 15% of patients with early-stage, non-bulky HL will relapse, and less than one third of those with advanced disease will relapse.\\u000a As therapy for HL intensified, and as disease-related outcomes improved, the impact of the late effects of therapy has become

Shrujal S. Baxi; Matthew J. Matasar



T-cell non-Hodgkin's lymphoma after radiotherapy and chemotherapy for Hodgkin's disease  

SciTech Connect

A rapidly fatal T-cell lymphoma developed in a 25-year-old man who, over a period of seven years, had been treated with radiotherapy and combination chemotherapy for Hodgkin's disease (HD). Non-Hodgkin's lymphoma (NHL) is increasingly being recognized as a late sequel of therapy for HD, but this is the first case in which NHL of T-cell type has been identified in such circumstances.

Lowenthal, R.M.; Harlow, R.W.H.; Mead, A.E.; Tuck, D.; Challis, D.R.



Mycosis fungoides. Demonstration of a variant simulating Hodgkin’s disease  

Microsoft Academic Search

Summary  In a patient exhibiting features of both mycosis fungoides and Hodgkin’s disease a cytomorphological analysis indicated that\\u000a only one type of abnormal cell was involved. This cell was part of a population of otherwise characteristic mycosis fungoides\\u000a cells which, however, showed a marked tendency to bi- and multinucleation, thus resembling Sternberg-Reed cells.\\u000a \\u000a Histopathological and cytomorphological discriminants between the two diseases

S. C. J. van der Putte; J. Toonstra; D. M. D. S. Go; J. A. M. van Unnik



Alopecia areata as a paraneoplastic syndrome of Hodgkin's lymphoma: A case report  

PubMed Central

Alopecia areata (AA) has been classically associated with several autoimmune disorders. However, AA as a paraneoplastic syndrome of Hodgkin’s lymphoma (HL) remains a rare entity and our understanding of this phenomenon is limited to a few case reports. This is the case report of a 46-year-old male patient who was diagnosed with AA several months prior to the onset of B symptoms and the diagnosis of stage IVB classical HL. The patient was subsequently treated with 6 cycles of adriamycin, bleomycin, vinblastine and dacarbazine and experienced a complete response and resolution of his AA. In our case, the onset of AA preceded the onset of systemic manifestations and diagnosis of HL, whereas in other cases AA was shown to occur concurrently with the clinical manifestations of HL. In all the cases, however, treatment of the HL subsequently led to resolution of the AA. The present case report highlights the significance of AA as a herald of underlying malignancy, although AA in classical HL remains poorly characterized in the literature.




Acute dysautonomia associated with Hodgkin's disease.  

PubMed Central

A patient is described with acute dysautonomia associated with Hodgkin's disease. Testing of cardiovascular reflex control showed that this patient had a rare manifestation of autonomic cardiovascular neuropathy, namely intact parasympathetic heart rate control in combination with a sympathetic postganglionic lesion affecting the control of the vascular tree.

van Lieshout, J J; Wieling, W; van Montfrans, G A; Settels, J J; Speelman, J D; Endert, E; Karemaker, J M



Non-Hodgkin's lymphoma in the elderly  

Microsoft Academic Search

With rising age the incidence of non-Hodgkin's lymphoma (NHL), together with the fact that the proportion of people older than 65 years in Western populations will double during the next 40 years, poses the challenge to adequately meet the needs of elderly patients. After a general introduction on cancer in the elderly, a review is given concerning aspects of epidemiology and prognostic

E. Maartense; H. C. Kluin-Nelemans; E. M. Noordijk



Non-Hodgkin's lymphoma--clinicopathological pattern.  


A study of histopathological and clinical features of non-Hodgkin's lymphoma in 495 consecutive cases, diagnosed at AFIP during 1984-1989 is presented. Children below the age of 15 years were not included in this study. The relative frequency of non-Hodgkin's lymphoma was 4.29% in our material. Non-Hodgkin's lymphoma was more frequent than Hodgkin's disease, ratio being 2.44:1. Lymphadenopathy (78.78%), fever (33.08%), weight loss (31.62%) and anemia (30.14%) were the main presenting features. New working formulation was used for morphological characterisation. Follicular lymphoma constituted 8.08% of all cases. Follicular lymphoma was seen only in older age whereas diffuse lymphoma occurred in all age groups. Intermediate and high grade lymphoma represented 73.54% of all NHL. Small lymphocytic lymphoma was common in low grade tumours (13.13%). Extra nodal lymphoma was encountered in a significant proportion (21.22%), gastrointestinal tract being the most frequent site. This study outlines certain interesting features of NHL in Pakistan. PMID:1433803

Ahmad, M; Khan, A H; Mansoor, A; Khan, M A; Saeed, S



ACR Appropriateness Criteria Pediatric Hodgkin Lymphoma.  


Pediatric Hodgkin lymphoma is a highly curable malignancy and potential long-term effects of therapy need to be considered in optimizing clinical care. An expert panel was convened to reach consensus on the most appropriate approach to evaluation and treatment of pediatric Hodgkin lymphoma. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 2 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances where evidence is lacking or not definitive, expert opinion may be used to recommend imaging or treatment. Four clinical variants were developed to assess common clinical scenarios and render recommendations for evaluation and treatment approaches to pediatric Hodgkin lymphoma. We provide a summary of the literature as well as numerical ratings with commentary. By combining available data in published literature and expert medical opinion, we present a consensus to the approach for management of pediatric Hodgkin lymphoma. PMID:24616347

Terezakis, Stephanie A; Metzger, Monika L; Hodgson, David C; Schwartz, Cindy L; Advani, Ranjana; Flowers, Christopher R; Hoppe, Bradford S; Ng, Andrea; Roberts, Kenneth B; Shapiro, Ronald; Wilder, Richard B; Yunes, Michael J; Constine, Louis S



Autoimmune Hemolytic Anemia and Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Rare Association  

PubMed Central

Autoimmune hemolytic anemia (AIHA) has been associated with chronic lymphocytic leukemia, non-Hodgkin lymphoma, and classical Hodgkin lymphoma, but to the best of our knowledge, the association of AIHA and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has not been reported previously. A 20-year-old woman presented with conjunctival jaundice, fever, asthenia, and hemoglobin 9.2?g/dL revealing IgG-mediated warm antibody AIHA. Computed tomography (CT) scan and positron-emission tomography (PET) scan showed mediastinal and axillary lymph nodes with increased [18F]-fluorodeoxyglucose uptake. A mediastinal lymph node was biopsied during mediastinoscopy, and NLPHL was diagnosed by an expert hematopathologist. The hemoglobin level declined to 4.6?g/dL. The treatment consisted of four 28-day cycles of R-ABVD (rituximab 375?mg/m2 IV, adriamycin 25?mg/m2 IV, bleomycin 10?mg/m2 IV, vinblastine 6?mg/m2 IV, and dacarbazine 375?mg/m2 IV, each on days 1 and 15). Prednisone was progressively tapered over 10 weeks. After the first chemotherapy cycle, the hemoglobin level rose to 12?g/dL. After the four cycles, PET and CT scans showed complete remission (CR). At the last followup (4 years), AIHA and NLPHL were in sustained CR.

Salmeron, Geraldine; Molina, Thierry Jo; Fieschi, Claire; Zagdanski, Anne-Marie; Brice, Pauline



Hodgkin's lymphoma rectosigmoid in a patient with ulcerative colitis on long-term azathioprine therapy.  


Hodgkin's lymphoma complicating chronic ulcerative colitis is extremely rare. We report a case of extranodal Hodgkin's lymphoma involving rectosigmoid in a patient of chronic ulcerative colitis on long-term azathioprine. A 67-year-old man presented with extensive ulcerative colitis, on follow-up since September 2005. He received long-term steroids, mesalamine and azathioprine. Serial surveillance colonoscopic examinations and colonic biopsies were performed. Surveillance colonoscopy performed 8?years after the onset of disease showed multiple deep ulcers and nodular masses involving the rectum and sigmoid colon. Histological examination of rectosigmoid biopsies showed classic Hodgkin's disease. Azathioprine was withdrawn. He received mechlorethamine, vincristine, procarbazine and prednisone (MOPP) chemotherapy protocol and was planned for total colectomy in follow-up. We believe patients with ulcerative colitis on long-term azathioprine should be on vigil for development of lymphomas by protocol surveillance colonoscopic examinations and biopsies. The risk of lymphoma in such patients is small and outweighs the benefits of long-term azathioprine therapy. PMID:24849639

Khuroo, Mehnaaz S



Autoimmune hemolytic anemia and nodular lymphocyte-predominant hodgkin lymphoma: a rare association.  


Autoimmune hemolytic anemia (AIHA) has been associated with chronic lymphocytic leukemia, non-Hodgkin lymphoma, and classical Hodgkin lymphoma, but to the best of our knowledge, the association of AIHA and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has not been reported previously. A 20-year-old woman presented with conjunctival jaundice, fever, asthenia, and hemoglobin 9.2?g/dL revealing IgG-mediated warm antibody AIHA. Computed tomography (CT) scan and positron-emission tomography (PET) scan showed mediastinal and axillary lymph nodes with increased [(18)F]-fluorodeoxyglucose uptake. A mediastinal lymph node was biopsied during mediastinoscopy, and NLPHL was diagnosed by an expert hematopathologist. The hemoglobin level declined to 4.6?g/dL. The treatment consisted of four 28-day cycles of R-ABVD (rituximab 375?mg/m(2) IV, adriamycin 25?mg/m(2) IV, bleomycin 10?mg/m(2) IV, vinblastine 6?mg/m(2) IV, and dacarbazine 375?mg/m(2) IV, each on days 1 and 15). Prednisone was progressively tapered over 10 weeks. After the first chemotherapy cycle, the hemoglobin level rose to 12?g/dL. After the four cycles, PET and CT scans showed complete remission (CR). At the last followup (4 years), AIHA and NLPHL were in sustained CR. PMID:23710384

Salmeron, Géraldine; Molina, Thierry Jo; Fieschi, Claire; Zagdanski, Anne-Marie; Brice, Pauline; Sibon, David



Role of brentuximab vedotin in the treatment of relapsed or refractory Hodgkin lymphoma  

PubMed Central

Brentuximab vedotin (BV) is an antibody-drug conjugate that targets CD30-positive malignancies via an anti-CD30 monoclonal antibody linked to monomethyl auristatin E, a microtubule-disrupting agent, by a protease-cleavable linker. BV has received accelerated approval from the US Food and Drug Administration for the treatment of classical Hodgkin lymphoma that has relapsed either after autologous stem cell transplantation (ASCT) or after two lines of combination chemotherapy in patients ineligible for ASCT, and in systemic anaplastic large cell lymphoma after failure of at least one line of multiagent chemotherapy. Phase I studies in CD30-positive lymphomas have determined the maximum tolerated dose to be 1.8 mg/kg intravenously every 21 days. In relapsed/refractory Hodgkin lymphoma, a pivotal Phase II study of single-agent BV showed an overall response rate of 75%, with 34% complete responses and a median remission duration of 20 months for complete responders. BV has a modest toxicity profile, with peripheral neuropathy as one of the most clinically significant side effects, and this is largely reversible. Therefore, BV is the treatment of choice for patients with relapsed/refractory Hodgkin lymphoma after ASCT or two standard regimens. Ongoing trials are evaluating the role of BV as salvage therapy prior to ASCT and for maintenance after ASCT for patients with relapsed/refractory disease.

Siddiqi, Tanya; Thomas, Sandra H; Chen, Robert



The Internet Classics Archive  

NSDL National Science Digital Library

The Internet Classics Archive has recently been extensively updated and more than doubled in size. This premier classical literature resource now offers 375 works by 30 classical authors, in English translation. The complete body of work is attractively and logically formatted for easy and swift browsing. It is supported by a newly improved search engine. The Tech Classics Archive is a non-commercial, student-created World-Wide Web site that will be one year old in October.



What Are the Key Statistics for Non-Hodgkin Lymphoma in Children?  


... Hodgkin lymphoma in children? What are the key statistics for non-Hodgkin lymphoma in children? Non-Hodgkin ... but is uncommon in children younger than 3. Statistics on survival can be found in the section “ ...


The Classical Vacuum.  

ERIC Educational Resources Information Center

The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Boyer, Timothy H.



Non-Hodgkin's Lymphomas in U.S. Navy Personnel  

Microsoft Academic Search

Non-Hodgkin's lymphomas are one of the most commonly occurring cancers in the age groups heavily represented in the U.S. Navy. The Navy has a wide range of potential occupational exposures. This study was initiated to identify any occupational associations of non-Hodgkin's lymphomas that may adversely affect naval readiness. The objective of this study was to compare the incidence of non-Hodgkin's

Frank C. Garland; Edward D. Gorham; Cedric F. Garland; Jay A. Ferns



Molecular single-cell analysis of Hodgkin- and Reed-Sternberg cells harboring unmutated immunoglobulin variable region genes.  


Hodgkin- and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease of the B lineage are the clonal progeny of antigen-experienced B cells harboring highly mutated immunoglobulin variable (V) region genes. Based on the detection of obviously destructive somatic mutations in a fraction of cases, we speculated that H/RS cells may be derived from a pre-apoptotic germinal center B cell. Seemingly contradicting this speculation, we present here the first case of classical Hodgkin's disease with H/RS cells harboring unmutated, potentially functional V region genes, which may indicate the derivation of the H/RS clone from a naive B cell. However, germinal center founder cells, which have not yet acquired somatic mutations, already have the intrinsic propensity to die by apoptosis. Thus, the rare occurrence of H/RS cells with unmutated V genes is expected if the H/RS cells are derived from the pool of pre-apoptotic germinal center B cells. PMID:11310822

Müschen, M; Küppers, R; Spieker, T; Bräuninger, A; Rajewsky, K; Hansmann, M L



Paraneoplastic cerebellar degeneration in Hodgkin's lymphoma.  


Paraneoplastic cerebellar degeneration (PCD) is a rare disorder presenting typically with acute or subacute severe cerebellar ataxia. PCD is most commonly associated with small cell lung cancer followed by adenocarcinoma of breast and ovary, and Hogdkin's lymphoma. We report a case of a 54-year-old male with acute-onset pancerebellar syndrome with underlying Hodgkin's lymphoma. A high index of suspicion of PCD resulted in arriving at an early diagnosis of underlying Hodgkin's disease. The patient was managed with six cycles of chemotherapy, which resulted in clinical stabilization and reversal of magnetic resonance imaging abnormalities. Antitumor therapy appears to have a significant impact on reversing PCD and hence early diagnosis and intervention for the primary remains the corner stone in stabilizing the neurological condition. PMID:22919195

Suri, Vinit; Khan, Nadeem I; Jadhao, Nilesh; Gupta, Rohan



Klinefelter Syndrome and Non-Hodgkin Lymphoma  

Microsoft Academic Search

Patients with a 47,XXYkaryotype (Klinefelter syndrome) appear to have on increased risk of developing cancer, especially male breast cancer and germ cell tumors, but rarely malignant hematologic disorders. We report a patient with a low grade B-cell non-Hodgkin lymphoma with a 47,XXY karyotype in both the tumor and constitutional cells. This is only the 13th reported case of malignant lymphoma

Mervyn Humphreys; Philip Lavery; Curly Morris; Norman Nevin



Histone deacetylase inhibitors in Hodgkin lymphoma  

Microsoft Academic Search

Summary  Although Hodgkin lymphoma (HL) is considered one of the most curable human cancers, the treatment of patients with relapsed\\u000a and refractory disease, especially those who relapse after autologous stem cell transplantation, remains challenging. Furthermore,\\u000a because of the young age of these patients, the impact of early mortality on the number of years lost from productive life\\u000a is remarkable. Patients with

Daniela Buglio; Anas Younes



Principles of Radiation Techniques in Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Radiation therapy (RT) is a major component of the current successful treatment of Hodgkin lymphoma (HL). For decades, radiation\\u000a was used alone to cure the majority of patients with HL; RT is still the most effective single agent in the the oncologic\\u000a armamentarium for this disease, and it remains the treatment of choice for patients with early-stage lymphocye predominance\\u000a HL

Joachim Yahalom; Richard T. Hoppe


Treatment of Early Favorable Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Most research groups define favorable early Hodgkin lymphoma (HL) as stage I–II disease without risk factors. The vast majority\\u000a of these patients can be cured with chemotherapy, radiotherapy, or with combined modality approaches. Before the introduction\\u000a of combined modality approaches, large-field radiotherapy had resulted in very good tumor control, but relapses occurred in\\u000a approximately 30% of patients, with most recurrences

Elly Lugtenburg; Anton Hagenbeek


Non-Hodgkin Lymphoma: Diagnosis and Treatment  

Microsoft Academic Search

Non-Hodgkin lymphomas are a heterogeneous group of malignan- cies of the lymphoid system. Based on the World Health Organiza- tion classification of hematological and lymphoid tumors, these diseases have been classified as B-cell and T-cell neoplasms. B- cell lymphomas account for approximately 90% of all lymphomas, and the 2 most common histological disease entities are follicular lymphoma and diffuse large




Extensions of Classical Hydrodynamics  

NASA Astrophysics Data System (ADS)

An abstract dynamical system is formulated from three features extracted from classical hydrodynamics. One its particular realization is then the classical hydrodynamics, other possible realizations are extensions of the classical hydrodynamics. The three features entering the formulation of the abstract dynamical system are the conservation laws, the compatibility with equilibrium thermodynamics, and the compatibility with classical mechanics in the limit of no dissipation. The particular extensions on which we illustrate the process of constructing different realizations are those arising when dealing with fluids in the vicinity of gas-liquid phase transitions (i.e. fluids involving large spatial inhomogeneities and large fluctuations).

Grmela, Miroslav



Prevalence of human endogenous retroviral element associates with Hodgkin's lymphoma incidence rates.  


Human endogenous retrovirus-H (HERV-H) is implicated in leukaemias and lymphomas, but the precise molecular mechanism underlying HERV-mediated carcinogenesis remains unknown. We determined the prevalence of HERV-H in a cross-section of the Singapore population and explored the relationship between HERV-H positivity and incidence rates for Hodgkin's lymphoma in three major ethnic groups of Singapore. We observed that Malays were 1.11 times likely (95% CI=1.05-1.17; P<0.01), and Indians 1.12 times likely (95% CI=1.07-1.18; P<0.01) to be HERV-H positive when compared to Chinese. Interestingly, the incidence rates of Hodgkin's lymphoma for the three races positively correlated to the respective prevalence rate for HERV-H positivity (r=0.9921 for male; r=0.9801 for female), suggesting that viral inheritance in human may predispose certain racial origin unfavourably to malignancy. PMID:24596672

Woo, Wee Hong; Shen, Liang; Leong, Sai Mun; Koay, Evelyn Siew-Chuan



Levamisole in the treatment of Hodgkin's disease.  


In vitro and in vivo action of levamisole has been studied in patients with Hodgkin's disease. In vitro levamisole significantly increased the active T cell count of 35 untreated active patients, of those being in complete remission after treatment and of 19 healthy controls; it significantly raised the total T cell count of patients. However, levamisole could not further improve the considerably increased active and total spontaneous rosette formation resulting from in vivo levamisole treatment. Twenty patients with Hodgkin's disease, being in complete remission, were given levamisole for 3 or 6 months, according to 2 different schedules. Levamisole (150 mg) given on 3 consecutive days of every second week for 3 months considerably increased the number of positive skin tests (from 8/60 to 29/60), the numbers of active and total T cells with unchanged absolute lymphocyte count, and decreased the quantity of circulating immune complex. Continuation of treatment for another 3 months resulted in slight, but consistent, decline in all the above parameters; the ratio of active T cells significantly decreased. This decline was even more pronounced if a raised larger dosage of levamisole was administered for 6 months. In the course of the treatment no side-effect or complication was observed. Levamisole is able to improve the weak cellular immune reactivity of patients with Hodgkin's disease, it can, however, result in undesired suppression in the case of too long treatment with high dose. PMID:317549

Berényi, E; Kávai, M; Szabolcsi, M; Szegedi, G



Treatment Outcome of Limited Stage Hodgkin's Disease  

PubMed Central

Purpose The 10-year overall survival rate following conventional treatments for patients with limited-stage Hodgkin's disease (HD) exceeds 90%. However, the clinical features and treatment outcome of HD in Korea have not been extensively characterized due to its low incidence. In this study, we attempted to analyze the treatment outcome of different modalities in limited stage HD patients. Materials and Methods Twenty one Hodgkin's disease patients, referred to the Samsung Medical Center between January 1997 and December 2003, were enrolled in this study. Limited stage Hodgkin's disease was subdivided into low and high risk groups. All evaluable patients received treatment. Results There were 13 and 8 patients in the low and high risk groups, respectively. Eighteen patients (86%) obtained complete response (CR) and 3 patients (14%) achieved an undetermined complete response (CRu). Fourteen (67%), 4 (19%) and 3 (14%) cases received combination chemotherapy, radiotherapy alone and chemotherapy alone, respectively. Four cases relapsed and 2 obtained a second CR. The 5-year overall and disease-free survival rates were 90 and 72%, respectively, for all patients. The median follow-up duration was 31 months. There was no difference in disease free survival (DFS) between the low and high risk groups. Although 12 cases had neutropenia greater than grade III, none experienced neutropenic fever. Conclusion The treatment outcome of limited-stage HD was excellent, regardless to the initial treatment modality.

Kang, Jung Hun; Ahn, Yong Chan; Kim, Won Seog



Lenalidomide induced good clinical response in a patient with multiple relapsed and refractory Hodgkin's lymphoma  

PubMed Central

Background A 24-year-old female patient was diagnosed with classic Hodgkin's lymphoma in clinical stage II, and combination chemotherapy followed by radiotherapy was initiated. During the following 5 years, the disease progressed despite several standard therapeutic approaches, including autologous and allogeneic stem cell transplantation. Methods Lenalidomide (25 mg daily) treatment was then initiated in a continuous dosing schedule. Positron emission tomography scans were performed before and during lenalidomide treatment. Hematologic and laboratory values, as well as physical condition were also assessed before and during lenalidomide treatment. Results Four months after continuous lenalidomide treatment, tumor load was significantly reduced, B symptoms had resolved, and the patient's physical condition had improved, allowing her to resume normal daily-living activities. Evaluations after 15 months of lenalidomide treatment indicated limited disease progression. Nevertheless, the patient was feeling well and maintaining a normal active life. Treatment was well tolerated, allowing the patient to remain on continuous dosing, which has now been maintained for 18 months. Conclusion Daily, long-term lenalidomide treatment provided clinical benefit and was well tolerated in a patient with relapsed, advanced classic Hodgkin's lymphoma.



Primary bone marrow B-cell non-Hodgkin's lymphoma successfully treated with R-CHOP.  


Primary isolated bone marrow disease as a presenting feature of lymphoma is very rare. We describe the case of a Chinese with isolated bone marrow small B-cell lymphoma as a first manifestation. A 55-year old woman was admitted to our hospital with fever. Her peripheral blood smear and laboratory findings were suggestive of bicytopenia. Bone marrow specimen showed diffusely distributed small-sized lymphocytes. Combined with immunophenotypic and chromosomal analysis, a diagnosis of primary bone marrow B-cell non-Hodgkin's lymphoma was made. The patient was treated with R-CHOP (rituximab and cyclophosphamide, epirubicin, vindesine, and prednisone) regimen for six cycles. She had complete remission and is still alive without relapse. We concluded that primary bone marrow mature small B-cell lymphoma is a rare but distinctive subtype of lymphoma. The prognosis for this entity is poor but rituximab-based treatment is promising for improving its outcomes. PMID:24171336

Qian, Liren; Zhang, Zhi; Shen, Jianliang; Liu, Yi



Chinese Folktales for Children.  

ERIC Educational Resources Information Center

This bilingual text contains ten traditional Chinese folktales which have been rewritten for children. Each story deals with interpersonal relationships and/or stresses the Chinese way of life. Each page of text is given first in English and then in Chinese and is illustrated with a full-page drawing. The titles of the folktales are: (1) "One…

Kwok, Irene


An update on emerging drugs for Hodgkin lymphoma.  


Introduction: Most patients with Hodgkin lymphoma (HL) are cured with modern combined modality first-line treatments. Even ? 50% of patients with relapsed/refractory HL can be cured with high-dose chemotherapy (HDCT) and autologous stem cell transplantation. However, chemotherapy and radiotherapy cause significant acute and long-term side effects and patients relapsing after HDCT have a dismal prognosis. New drugs are therefore needed to reduce the toxicity of first-line treatments and to increase the efficacy of relapse treatments. Moreover, new drugs are needed for the treatment of older patients with HL because results with current treatments are disappointing. Areas covered: This article discusses promising new drugs for the treatment of classical HL that have been evaluated in the last years. There is a focus on the antibody drug conjugate brentuximab vedotin and its potential for the future treatment of HL. Moreover, data on the histone deacetylase inhibitors panobinostat and mocetinostat, the mammalian target of rapamycin inhibitor everolimus, the Janus kinase 2 inhibitor SB1518 and the immunomodulatory agent lenalidomide are summarized. Expert opinion: Besides improving the prognosis of relapsed patients, new drugs should be used to replace the most toxic compounds in first-line therapy to reduce acute and long-term toxicities of the treatment. PMID:24749769

von Tresckow, Bastian; Diehl, Volker



Neighborhood socioeconomic status and Hodgkin's lymphoma incidence in California.  


Hodgkin's lymphoma occurrence has long been noted to associate with higher socioeconomic status (SES). However, the Hodgkin's lymphoma-SES association has not been examined recently or across important, possibly etiologically distinct, patient subgroups. In approximately 150 million person-years of observation in the multiethnic population of California, we examined the association of Hodgkin's lymphoma incidence with a composite measure of neighborhood-level SES in patient subgroups defined by age, sex, race/ethnicity, and Hodgkin's lymphoma histologic subtype. Using population-based cancer registry data on 3,794 Hodgkin's lymphoma patients diagnosed 1988 to 1992 and 1990 census data, we assigned a previously validated, multidimensional SES index to census block groups of patient residence. We then calculated neighborhood SES-specific incidence rates and estimated rate ratios using Poisson regression. Positive neighborhood SES gradients in Hodgkin's lymphoma incidence were observed only in young adults (ages 15-44 years at diagnosis) with nodular sclerosis Hodgkin's lymphoma and older adult (ages > or =45 years) White and Hispanic males with mixed cellularity Hodgkin's lymphoma. For young adults, associations were marked in Hispanic and Asian women, weaker in Hispanic and White men and White women, and subtle to nonexistent in Blacks and Asian men. Neighborhood SES gradients in Hodgkin's lymphoma incidence varied by age, sex, race/ethnicity, and histologic subtype, underscoring etiologic complexity in Hodgkin's lymphoma. Racial/ethnic gradients were not entirely explained by neighborhood SES. In California, etiologically relevant exposures for young adult Hodgkin's lymphoma, the most common form, could associate more with race/ethnicity or foreign birthplace than neighborhood SES and may be modified by reproductive or other sex-specific factors. PMID:15941953

Clarke, Christina A; Glaser, Sally L; Keegan, Theresa H M; Stroup, Antoinette



Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia



Autonomic dysfunction in Hodgkin and non-Hodgkin lymphoma. A paraneoplastic syndrome?  

PubMed Central

We wanted to determine whether autonomic dysfunction in patients with lymphoma is related to chemotherapy or represent a paraneoplastic syndrome. 40 patients with current or cured Hodgkin or non-Hodgkin lymphoma and 40 healthy controls, matched for age, gender, hypertension and diabetes mellitus underwent autonomic evaluation (Deep Breath, Valsalva Maneuver, Hand Grip, Lying to Standing, Tilt Test). Current patients also suffering from diabetes or hypertension, or still on chemotherapy revealed autonomic changes, while cured or healthy subjects did not. Autonomic dysfunction in lymphoma is a transient manifestation of a paraneoplastic syndrome.

Bilora, Franca; Veronese, Francesco; Zancan, Alice; Biasiolo, Michela; Pomerri, Fabio; Muzzio, Pier Carlo



The Classics, Con Brio  

ERIC Educational Resources Information Center

Sponsored by a consortium of 30 American universities, Rome's Intercollegiate Center for Classical Studies offers a year of study to American undergraduate classics majors. Instructors are also American and normally stay only a year; teaching assistants are always ex-students of the center. Extensive field trips are an important part of the…

Hansen, James



Teaching the Classics.  

ERIC Educational Resources Information Center

Outlines strategies for effectively teaching classic works of sociological theory to undergraduate sociology majors. Suggests placing a heightened emphasis on writing, opening the class to as much discussion as possible, and forming student reading groups. Selects classic works to be read and an order in which to teach them. (DB)

Segady, Thomas W.



Immunocytological diagnosis of primary cerebral non-Hodgkin's lymphoma  

Microsoft Academic Search

Four men with primary cerebral non-Hodgkin's lymphoma diagnosed by immunocytological analysis of cerebrospinal fluid (CSF) presented with cranial nerve palsies. All had CSF lymphocytoses and low CSF glucose. The cell phenotypes were two T cell tumours, one B cell, and one null. A review of 13 previously recorded cases of immunocytologically diagnosed CNS non-Hodgkin's lymphoma showed that there were 10

A P Lai; A S Wierzbicki; P M Norman



What You Need To Know About™ Hodgkin Lymphoma

What You Need To Know About™ Hodgkin Lymphoma Describes treatment options, types of cancer doctors, second opinion, follow-up care, and sources of support for someone recently diagnosed with Hodgkin lymphoma. For Kindle | For Other E-readers E-Books Collection


Neuralgic amyotrophy in association with radiation therapy for Hodgkin's disease  

SciTech Connect

We describe 4 patients with Hodgkin's disease who developed neuralgic amyotrophy in the setting of radiation therapy. In contrast to tumor progression or radiation plexopathy, the symptom onset was abrupt and occurred within days to weeks of receiving radiation treatments. There is an association between Hodgkin's disease, radiation therapy, and neuralgic amyotrophy.

Malow, B.A.; Dawson, D.M. (Brigham and Women's Hospital, Boston, MA (USA))



Hodgkin's disease of the prostate: a detailed case report  

SciTech Connect

Malignant lymphoma of the prostate is an unusual entity, and nonHodgkin's lymphoma constitutes most reported cases. We report a well documented case of Hodgkin's lymphoma, initially involving the gastrointestinal tract and spleen, which recurred in the prostate following initial remission with chemotherapy. Treatment with external beam radiotherapy resulted in a rapid complete response that has been sustained for 18 months.

Klotz, L.H.; Herr, H.W.



Asthma combined with Hodgkin's lymphoma: a case report and review of the literature  

PubMed Central

Both asthma and hematological malignancies are influenced by genetic and environmental factors. The previous studies have revealed lymphoma were found among atopic men and women. However, the relationship between asthma and Hodgkin’s lymphoma has not been well recognized. We present here, a case of a 53-year-old male patient suffered asthma and then Hodgkin’s lymphoma.

Gu, Shuyi; Guo, Yi; Wan, Huanying



3D Guqin: Digital Playground to Explore Music that Embodies Chinese Culture and Philosophy  

Microsoft Academic Search

This media art installation aims to digitally reconstruct a traditional Chinese Guqin string instrument using physical sensing techniques, to invite bodily interpretation of the classical instrument. Guqin has a unique place in the Chinese history, as a symbol of the high culture of the nobles and intellectuals (Junzi, Superior Man). It's also seen as the vessel for pursuing harmony. Guqin

Eng Tat Khoo; Roshan Lalintha Peiris; Matthias Rauterberg



The Hodgkin-Huxley Heritage: From Channels to Circuits  

PubMed Central

The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin’s and Huxley’s ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost.

Catterall, William A.; Raman, Indira M.; Robinson, Hugh P. C.; Sejnowski, Terrence J.; Paulsen, Ole



Use of Leu M1 and antiepithelial membrane antigen monoclonal antibodies for diagnosing Hodgkin's disease.  

PubMed Central

Biopsies of 82 patients diagnosed as having Hodgkin's disease were reviewed. Seventeen were reclassified histologically as non-Hodgkin's lymphoma or reactive lymphoid hyperplasia. A substantial number of cases of Hodgkin's disease were negative when stained with Leu M1. Staining for Leu M1 was not found in the cases of non-Hodgkin's lymphoma or reactive lymphoid hyperplasia. With the exception of the lymphocyte predominant nodular subtype of Hodgkin's disease, epithelial membrane antigen staining was seen in a few cases of Hodgkin's disease and non-Hodgkin's lymphomas. This was not a useful discriminating feature. Images

Jack, A S; Cunningham, D; Soukop, M; Liddle, C N; Lee, F D



Thalidomide for the Control of Severe Paraneoplastic Pruritus Associated With Hodgkin’s Disease  

Microsoft Academic Search

A 22-year-old woman with nodular sclerosis type II Hodgkin lymphoma diagnosed in June 2001. She initially underwent chemotherapy with 6 cycles of ABVD (adriamycin, bleomycin, vincristine, dacarbazine) regimen, leading to clinical remission. As it relapsed, she was again treated with 2 different chemotherapy regimens. In November 2003, she underwent bone marrow autotransplantation, but it relapsed after 2 months. After that,

Ferraz Gonçalves



CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia



Solid tumors in patients treated for Hodgkin's disease: a report from the German Hodgkin Lymphoma Study Group  

Microsoft Academic Search

Background: Long-term survivors of successfully treated Hodgkin's disease (HD) are at risk for late complications. Among these, secondary solid tumors are most serious because they are often fatal. The aim of this retrospective analysis was to assess the incidence, relative risk and risk factors of secondary solid tumors in HD patients registered in the database of the German Hodgkin Lym-

K. Behringer; A. Josting; P. Schiller; H. T. Eich; H. Bredenfeld; V. Diehl; A. Engert



Prognostic factors and treatment outcome in primary progressive Hodgkin lymphoma: a report from the German Hodgkin Lymphoma Study Group  

Microsoft Academic Search

To determine prognostic factors and treat- ment outcome, patients with primary pro- gressive Hodgkin lymphoma (HD) regis- tered in the database of the German Hodgkin Lymphoma Study Group (GHSG) were analyzed retrospectively. Detailed records from randomized prospective multicenter trials performed between 1988 and 1998 of 3807 patients recruited in these trials were reviewed. The median age of the 206 patients

Andreas Josting; Ulrich Rueffer; Jeremy Franklin; Markus Sieber; Volker Diehl; Andreas Engert



Precipitable immune complexes in Hodgkin's disease.  


Sera from 28 untreated patients with Hodgkin's disease and from 120 healthy controls were investigated for the presence of circulating immune complexes using a modified 3% polyethylene glycol precipitation method with subsequent quantification of the precipitated protein. Elevated levels of precipitable protein were found in 79% (p less than 0.005) of Hodgkin's disease sera. The degree of elevation was associated with disease activity including the presence of B-symptoms. Constant and pronounced increase of precipitable protein was found in six patients with stage-III B nodular sclerosis subtype, thus exceeding the average amount of precipitable protein in healthy controls by a factor of 3-4. The erythrocyte sedimentation rate in 20 patients correlated with the amount of precipitable protein (r = 0.79). Additionally, partial component analysis of the precipitates was carried out by laser nephelometry. Immunoglobulins and complement components were identified as being major components of the precipitated material in sera both from patients and healthy controls, thus confirming the probability of the immune complex nature of the precipitates. Significant differences between patients and healthy controls concerned the amount of precipitable components. Elevation of precipitable IgM was found to be the most sensitive parameter (86% above means + 2 SD of normal controls, p less than 0.005). Increased amounts of precipitable IgG, C4, and Clq were found in 57-46% of patients' sera. Elevation of precipitable IgA and C3c were identified less often. The results suggest the quantification of precipitable immune complexes and their components to be of value as adjuncts in determining disease activity in Hodgkin's disease. PMID:6618706

Euler, H H; Béress, R; Moldenhauer, I; Löffler, H



A Classical Science Transformed.  

ERIC Educational Resources Information Center

Describes how satellites and other tools of space technology have transformed classical geodesy into the science of space geodynamics. The establishment and the activities of the French Center for Geodynamic and Astronomical Research Studies (CERGA) are also included. (HM)

Kovalevsky, Jean



English-Chinese, Chinese-English Nuclear Security Glossary.  

National Technical Information Service (NTIS)

The U.S. National Academies Committee on International Security and Arms Control (CISAC) and the Chinese Scientists Group on Arms Control (CSGAC) of the Chinese People's Association for Peace and Disarmament have jointly produced a Chinese - English Engli...



Combination chemoradiotherapy in early Hodgkin lymphoma.  


Combination chemoradiotherapy achieves excellent results for the treatment of localized Hodgkin lymphoma. However, late toxic effects occur, mostly related to the radiotherapy administered after the standard adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. The most serious sequelae are radiation-induced secondary cancers. Reducing radiotherapy has not yet prevented late malignancies. However, when radiotherapy was omitted, tumor control was inferior, with more relapses necessitating rescue treatment including high-dose chemotherapy with stem cell support. Early fluorodeoxyglucose positron emission tomography performed after a few cycles of ABVD is evaluated in several randomized trials to identify patients who might be safely treated with chemotherapy alone. PMID:24287066

André, Marc P E



Recognizing unusual manifestations of Hodgkin lymphoma.  


Hodgkin lymphoma (HL) is a rare malignancy of the lymphatic system that is curable in at least 80 % of patients. Although patients usually present with painless lymphadenopathy, a variety of systemic and organ-specific syndromes may also exist in relation to HL. These syndromes may develop before, during, or after the diagnosis of HL and may also indicate disease relapse. Most of these unusual disorders resolve with successful HL treatment but some may require adjunctive supportive therapies before a response is achieved. Oncologists should be familiar with these syndromes because early recognition may result in a more timely diagnosis of HL which may lead to improved outcomes. PMID:22777500

Barber, Nicholas A; Bierman, Philip J



Pathology Case Study: History of Hodgkin's Disease  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 37-year-old man, previously diagnosed with stage III nodular sclerosing Hodgkin's Disease has recently had a brief episode of syncope. Visitors are given the gross descriptions and radiology, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in neuropathology.

Brown, Henry G.; Fox, Karl R.; Prostko, E. R.; Whiting, Donald M.; Zhang, Jin



Subnuclear realm: classical in quantum and quantum in classical  

SciTech Connect

Exact solutions in the classical Yang-Mills-Wong theory enable explaining a number of enigmatic classical features of subnuclear realm. Moreover, they reveal some unexpected quantum features of this classical treatment.

Kosyakov, B. P. [Theoretical Division, Russian Federal Nuclear Center, Sarov 607190 (Russian Federation)



Learn Chinese Characters  

NSDL National Science Digital Library is a valuable online resource for individuals just beginning to learn Chinese, as well as those who want to learn more. The site contains the complete on line text of "Chinese Character: A Genealogy and Dictionary". All the Chinese characters are hyperlinked so that users of the site can quickly decipher new and unfamiliar characters in English. Additionally, the site has readings about Chinese culture written in Chinese such as the "Art of War" and "Mao Sayings". Finally, for those who may just have basic questions about the Chinese language there is a frequently asked questions section that addresses common questions such as "Why are characters so complicated?" and "Are they pictures?"

Harbaugh, Rick



Long-term gonadal toxicity after therapy for Hodgkin's and non-Hodgkin's lymphoma.  


With the increasing cure rate of patients treated for Hodgkin's and non-Hodgkin's lymphoma, the evaluation of late effects on gonadal function remains an important issue. The gonadal function of relapse-free long-term survivors with high-grade non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (HD) were studied; 24 of 119 patients with NHL treated between 1980 and 1990 and 66 of 364 patients with HD treated between 1975 and 1990 at Hannover University Medical School, who were younger than 45 years of age and in complete remission at the time of evaluation for at least 24 months after completion of therapy, were included into the analysis. Of 24 patients with NHL, 1/10 women (10%) and only 3/14 men (21%) showed signs of gonadal dysfunction. Three of these four patients had been treated with combined modality therapy followed by maintenance COP chemotherapy, resulting in high cumulative doses of cyclophosphamide (range: 12-43 g). In comparison, 13/26 (50%) women with HD suffered from premature ovarian failure, and 26/40 (65%) men showed signs of gonadal dysfunction with significant FSH elevations. No significant difference in the incidence of gonadal toxicity existed in patients treated with combined modality who received irradiation to either supra- or infradiaphragmatic radiation fields in combination with chemotherapy (70% versus 62%). A comparison of the chemotherapy regimens used in patients with NHL or HD shows that patients from both groups had received comparable median cumulative doses of cyclophosphamide, vincristine, and adriamycin, but only patients with HD had additionally received a median cumulative dose of 13.3 g of procarbazine per patient. A tendency towards a higher incidence of gonadal toxicity with higher cumulative doses of procarbazine received was found in patients with HD. The frequency of gonadal dysfunctions is markedly lower in patients treated for non-Hodgkin's lymphoma than in patients treated for Hodgkin's disease, approximately half of whom will be affected by long-term gonadal toxicity. Although the use of more intensive radiotherapy in patients with HD compared with NHL patients makes the evaluation of the influence of radiotherapy on gonadal toxicity more difficult, the current retrospective analysis raises the concern that, in addition to infradiaphragmatic radiotherapy, the use of procarbazine in regimens for the treatment of HD, like COPP or MOPP, may be a possible explanation for the differences in gonadal toxicity observed between patients with HD and those with NHL. Regimens including procarbazine should be avoided in patients wanting to preserve fertility since alternative chemotherapies with at least equal efficacy are available. PMID:8167175

Bokemeyer, C; Schmoll, H J; van Rhee, J; Kuczyk, M; Schuppert, F; Poliwoda, H



Second cancers following non-Hodgkin's lymphoma  

SciTech Connect

The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed/expected (O/E) = 1.18; O = 1231). The O/E ratio increased significantly with time to reach 1.77 in 10-year survivors. Significant excesses were noted for acute nonlymphocytic leukemia (O/E = 2.88), cancers of the bladder (O/E = 1.30), kidney (O/E = 1.47), and lung (O/E = 1.57), malignant melanoma (O/E = 2.44), and Hodgkin's disease (O/E = 4.16). Chemotherapy appeared related to subsequent acute nonlymphocytic leukemia (ANLL) and bladder cancer. Radiation therapy was associated with ANLL and possibly cancers of the lung, bladder, and bone. Malignant melanoma was not clearly related to initial NHL treatment.

Travis, L.B.; Curtis, R.E.; Boice, J.D. Jr.; Hankey, B.F.; Fraumeni, J.F. Jr. (National Cancer Institute, Bethesda, MD (USA))



The molecular pathogenesis of Hodgkin lymphoma.  


Hodgkin lymphoma (HL) is an unusual malignancy in that the tumour cells, the Hodgkin and Reed-Sternberg (HRS) cells, are a minor component of the tumour mass, the bulk of which is a mixed cellular infiltrate. There is compelling evidence that HRS cells are clonal B cells that have lost their B cell phenotype. Mature B cells lacking B cell receptors would normally die by apoptosis, and therefore HRS cells must have developed mechanisms to facilitate survival. The escape from apoptosis and transcriptional reprogramming of HRS cells are interlinked and appear central to disease pathogenesis. Epstein-Barr virus (EBV) is present in the HRS cells of a proportion of cases and expresses genes with a plausible oncogenic function. It is likely that EBV plays a role in reprogramming and survival through dysregulation of several signalling networks and transcription factors, including nuclear factor (NF)-?B. Activation of NF-?B is a feature of all HRS cells and gene mutations affecting this pathway appear common in EBV-negative HL. The HRS cell furthers its own survival by attracting a supportive microenvironment of immune and stromal cells, and suppressing local immune responsiveness. Although many questions remain unanswered, the last two decades have witnessed a considerable increase in our knowledge of this complex disease. PMID:21261680

Farrell, Katrina; Jarrett, Ruth F



The treatment of stage IIIA Hodgkin's disease  

SciTech Connect

Sixty consecutive previously untreated adults with surgically confirmed stage IIIA Hodgkin's disease (39 stage IIIA1, 21 stage IIIA2) began therapy at St. Bartholomew's Hospital between 1969 and 1981. Prior to 1973, treatment consisted of total nodal irradiation (TNI). From 1973 until 1978 patients were randomly allocated to receive either TNI or cyclic combination chemotherapy of mustine, vinblastine, prednisolone, and procarbazine (MVPP) as part of a Medical Research Council Trial. Since 1978 treatment has been allocated according to substage, those with stage IIIA1 receiving TNI and those with stage IIIA2 receiving MVPP. Seven patients received ''non protocol'' therapy (extended mantle radiotherapy in three patients, mantle and MVPP in four patients), and have been excluded from the study. Complete remission was achieved in 48 of 53 patients regardless of substage or therapy. Seven have relapsed, one after MVPP and six after TNI. The predicted freedom-from-relapse after MVPP was 96% compared with 60% after TNI, both at 10 years (p less than 0.01). The relapse pattern was the same for both substages in the group receiving TNI. Although overall survival of patients receiving TNI was identical to that of those receiving MVPP, TNI must be considered inappropriate therapy for stage IIIA Hodgkin's disease if permanent freedom-from-recurrence is the goal.

Lister, T.A.; Dorreen, M.S.; Faux, M.; Jones, A.E.; Wrigley, P.F.



Thymic cysts following radiation therapy for Hodgkin disease  

SciTech Connect

In 3 patients, benign thymic cycsts developed following radiation therapy for Hodgkin disease. Autopsy or surgical specimens provided a diagnosis in all 3 cases; computed tomographic (CT) scans obtained in two of the patients provided a preoperative diagnosis. The etiology of these cysts is uncertain; they may arise following successful radiation treatment of Hodgkin disease involving the thymus. When an anterior mediastinal mass develops in a patient with Hodgkin disease following radiation therapy, careful evaluation to exclude a benign process is indicated prior to initiating additional therapy.

Baron, R.L.; Sagel, S.S.; Baglan, R.J.



Hyperhomocysteinaemia and premature coronary artery disease in the Chinese  

Microsoft Academic Search

OBJECTIVES: To examine the prevalence of hyperhomocysteinaemia and compare it with the classic risk factors and vitamin status in Hong Kong Chinese patients with premature atherosclerotic coronary artery disease. DESIGN: Case-control study. SETTING: General hospital and community. SUBJECTS: Forty five patients (39 males) with significant coronary artery disease confirmed by angiography (32 post myocardial infarction) and 23 healthy volunteers (17

Y. I. Lolin; J. E. Sanderson; S. K. Cheng; C. F. Chan; C. P. Pang; K. S. Woo; J. R. Masarei



Morphologic changes in the thyroid after irradiation for Hodgkin's and non-Hodgkin's lymphoma  

SciTech Connect

Four cases of thyroidectomy for suspected thyroid carcinoma after previous irradiation for Hodgkin's or non-Hodgkin's lymphoma are reviewed. The patients ranged in age from 18 to 33 years at the time of thyroid surgery with an average latency period of 12 years (range, 8-20 years) from radiation therapy to thyroidectomy. All patients had a clinically palpable thyroid nodule, and pathologically showed a pattern of multiple adenomatous nodules with cytologic atypia. The microscopic changes were sufficiently striking to cause the primary pathologist to request consultation to rule out thyroid carcinoma in each case. Fine-needle aspiration was performed in one case and suggested a thyroid neoplasm. The pathologic findings are reviewed and distinction of this lesion from thyroid carcinoma is discussed.

Carr, R.F.; LiVolsi, V.A.



Somatic mutations of the CD95 gene in Hodgkin and Reed-Sternberg cells.  


Hodgkin and Reed-Sternberg (H/RS) cells in classical Hodgkin's disease (cHD) are thought to be derived from preapoptotic germinal center B cells. However, little is known about the transforming events rescuing the precursor of the H/RS cells from apoptosis. Given the importance of CD95 (Apo-1/Fas)-mediated apoptosis for negative selection within the germinal center, single micromanipulated H/RS cells from 10 cases of cHD were analyzed for somatic mutations within the CD95 gene. Three clonal mutations within the 5' regions were amplified from single H/RS cells in one case. From H/RS cells of another case, two mutations within the last exon coding for the death domain were detected. About half of these H/RS cells carried a monoallelic stop-codon; the remaining tumor cells harbored a monoallelic replacement mutation. Both mutations likely impair CD95 function. Because all these H/RS cells also bear clonal mutations inactivating the IkappaB alpha gene, the IkappaB alpha mutations occurred earlier than those of the CD95 gene in the sequence of transforming events leading to cHD. In conclusion, somatic mutations of the CD95 gene occur in a fraction of cHD cases and may favor the escape of the precursor of the H/RS clone from apoptosis. PMID:11059754

Müschen, M; Re, D; Bräuninger, A; Wolf, J; Hansmann, M L; Diehl, V; Küppers, R; Rajewsky, K



Classical New England  

NSDL National Science Digital Library

Classical New England is a public service provided by WGBH in Boston with affiliate stations in Nantucket and Providence, Rhode Island. The cornucopia of music here can be explored via the Topics section on the right-hand side of the page. Here visitors can look through programs like "The Bach Hour" and "Classical Music With Cathy Fuller." Not surprisingly, there's an entire section dedicated to Tanglewood, which is the summer home of the Boston Symphony Orchestra (BSO) in western Massachusetts. One notable feature here is the last interview with celebrated music director and conductor Erich Leinsdorf, in which he ruminates on his time working with the BSO. Additionally, users can look over the Most Popular list to learn about what other classical music fans are enjoying. Finally, the site also includes videos of various performances from around New England and beyond.



Hodgkin's disease, work, and the environment. A review.  


Hodgkin's disease (HD), a lymphoma with an annual incidence in the United States of approximately 7500 cases, primarily affects the lymph nodes, spleen, and liver. The point of this article is to critically review the literature regarding the purported relationships between HD, certain occupations, and exposure to chemical agents. Attention will also be focused on recent advances in molecular genetics in the etiology of this ailment. A MEDLINE search was conducted to assess case-control and mortality evaluations that investigated links between HD and certain occupations and exposure to designated hazards. A review of citations in the Silver Platter Occupational and Environmental Medicine CD-ROM database was also conducted to ensure that all pertinent reports were obtained. Of the industries evaluated, woodworking showed the most consistent link between an increased risk of HD (relative risk, 1.8 to 7.2), but not all studies conducted showed positive associations. Although certain chemicals (ie, chlorophenols, pesticides) were reported as risks, no chemical was consistently and unambiguously linked with HD. Recent investigative work, however, points to a major etiological role for the Epstein-Barr virus (EBV), genetic fragments of which have been noted in Reed-Sternberg cells, the classic malignant cells of HD. The occupation most consistently associated with HD appears to be woodworking, although no specific chemical has been consistently linked with this lymphoma. The most persuasive evidence regarding the cause of HD arises from recent studies, including epidemiological, clinical, and genetic studies, that point to a major role by the EBV. PMID:9924719

McCunney, R J



Acoustical study of classical Peking Opera singing.  


Acoustic characteristics of classical opera singing differ considerably between the Western and the Chinese cultures. Singers in the classical Peking opera tradition specialize on one out of a limited number of standard roles. Audio and electroglottograph signals were recorded for four performers of the Old Man role and three performers of the Colorful Face role. Recordings were made of the singers' speech and when they sang recitatives and songs from their roles. Sound pressure level, fundamental frequency, and spectrum characteristics were analyzed. Histograms showing the distribution of fundamental frequency showed marked peaks for the songs, suggesting a scale tone structure. Some of the intervals between these peaks were similar to those used in Western music. Vibrato rate was about 3.5Hz, that is, considerably slower than in Western classical singing. Spectra of vibrato-free tones contained unbroken series of harmonic partials sometimes reaching up to 17 000Hz. Long-term-average spectrum (LTAS) curves showed no trace of a singer's formant cluster. However, the Colorful Face role singers' LTAS showed a marked peak near 3300Hz, somewhat similar to that found in Western pop music singers. The mean LTAS spectrum slope between 700 and 6000Hz decreased by about 0.2dB/octave per dB of equivalent sound level. PMID:21621380

Sundberg, Johan; Gu, Lide; Huang, Qiang; Huang, Ping



Diagnosis and Treatment of Non-Hodgkin's Lymphomas.  

National Technical Information Service (NTIS)

The Cancergram focuses on lymphomas including Hodgkin's disease. Abstracts are included which concern all clinical aspects of the various forms of lymphoma, such as diagnosis and staging, supportive care, evaluation, and therapy. Animal models, tissue cul...



General Information about Childhood Non-Hodgkin Lymphoma  


... children. Signs of childhood non-Hodgkin lymphoma include breathing problems and swollen lymph nodes. These and other ... your child has any of the following: Trouble breathing. Wheezing. Coughing. High-pitched breathing sounds. Swelling of ...


Primary non-Hodgkin's lymphoma of the ovaries: imaging findings.  


Primary ovarian lymphoma is very rare. We report a case of primary ovarian Burkitt-type non-Hodgkin's lymphoma, describing the imaging appearance on ultrasound, CT and MRI, and review the literature. PMID:17762045

Crawshaw, J; Sohaib, S A; Wotherspoon, A; Shepherd, J H



Diagnosis and Treatment of Non-Hodgkin's Lymphomas.  

National Technical Information Service (NTIS)

The Cancergram focuses on a group of lymphomas which includes adenolymphoma, Burkitt's lymphoma, lymphosarcoma, lymphoblastoma, lymphocytoma, reticulum cell sarcoma, mycosis fungoides, and any not otherwise specified lymphoma with the exception of Hodgkin...



Chinese Children's Songs.  

ERIC Educational Resources Information Center

Singing can be an enjoyable and effective way to motivate children to learn a second language. This booklet consists of contemporary and folk songs that are related to Chinese festivals, transportation, the family, seasons, Christmas and other topics. Each page gives the music to a song with the words in Chinese and in English. The songs are…

Kwok, Irene, Comp.


Predicate Movements in Chinese  

ERIC Educational Resources Information Center

The movements of such higher predicates as time, locative, and complementation verbs are studied, and Tai's Predicate Placement Constraint is rejected as an incorrect account of predicate movements in Chinese. It is proposed, on the other hand, that there is only leftward movement involving predicates in Chinese. (Author)

Shou-hsin, Teng



Chinese by Choice  

ERIC Educational Resources Information Center

A 2004 College Board survey revealed that school districts around America wanted to offer Chinese, but finding qualified teachers was a problem, says Selena Cantor, director of Chinese Language and Culture Initiatives for the College Board. So last year, a new College Board program brought guest teachers from China to school districts in 31…

Beem, Kate



Classical communication and non-classical fidelity of quantum teleportation  

NASA Astrophysics Data System (ADS)

In quantum teleportation, the role of entanglement has been much discussed. It is known that entanglement is necessary for achieving non-classical teleportation fidelity. Here we focus on the amount of classical communication that is necessary to obtain non-classical fidelity in teleportation. We quantify the amount of classical communication that is sufficient for achieving non-classical fidelity for two independent 1-bit and single 2-bits noisy classical channels. It is shown that on average 0.208 bits of classical communication is sufficient to get non-classical fidelity. We also find the necessary amount of classical communication in case of isotropic transformation. Finally we study how the amount of sufficient classical communication increases with weakening of entanglement used in the teleportation process.

Banik, Manik; Gazi, Md. Rajjak



Growing Up the Chinese Way: Chinese Child and Adolescent Development.  

ERIC Educational Resources Information Center

This volume is a collection of current research by noted scholars on Chinese child development. The volume re-examines long-held beliefs and preconceptions about Chinese culture, draws forth incompatible pictures and contradictory facts about Chinese children, and draws attention to new problems of the modern Chinese family. The chapters of the…

Lau, Sing, Ed.


Pancoast syndrome: A rare presentation of non-Hodgkin's lymphoma.  


Pancoast syndrome is a common presentation of bronchogenic carcinoma, but other malignancies are rarely cited as its cause. Pancoast syndrome due to non-Hodgkin's lymphoma is rarely described in the literature. Here, we report a case of Pancoast syndrome due to non-Hodgkin's lymphoma to increase the awareness of the clinicians regarding essentiality of tissue diagnosis of Pancoast tumor before starting the treatment. PMID:24049257

Sarkar, Anirban; Das, Anirban; Basuthakur, Sumitra; Pandit, Sudipta; Das, Sibes K; Choudhury, Sabyasachi



Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma  

Microsoft Academic Search

Sun exposure has been suggested to increase the risk of non-Hodgkin's lymphoma. The authors analyzed data from a population-based, case-control study of Connecticut women between 1996 and 2000 to study the hypoth- esis. Women who reported having had a suntan experienced an increased risk of non-Hodgkin's lymphoma with increasing duration (ptrend ¼ 0.0062) compared with women who reported never having

Yawei Zhang; Theodore R. Holford; Brian Leaderer; Peter Boyle; Yong Zhu; Rong Wang; Kaiyong Zou; Bing Zhang; John Pierce Wise; Qin Qin; Briseis Kilfoy; Jiali Han; Tongzhang Zheng


Primary non-Hodgkin's lymphoma of the mediastinum  

Microsoft Academic Search

Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6%) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extrathoracic disease at presentation. Eleven of the 12 patients presented with extensive contiguous extranodal disease (Stage II\\/sub E\\/)

Lee J. Levitt; Alan C. Aisenberg; Nancy L. Harris; Rita M. Linggood; Sibrand Poppema



Hypercalcaemia in Hodgkin's disease related to prostaglandin synthesis  

Microsoft Academic Search

A case of paraneoplastic hypercalcaemic syndrome is reported in a patient with Hodgkin's disease. This was detected eight months before widespread lymphadenopathy became apparent. Lymphocyte depleted Hodgkin's disease was diagnosed. PTH (parathyroid hormone) activity was suppressed and PTHRP (PTH related protein) was less than 5 pmol\\/l. 1,25(OH)2D3 was in the normal range. Plasma calcium values returned to normal after the

J B Laforga; J Vierna; F I Aranda



Thermodynamics and Classical Relativity  

Microsoft Academic Search

The classical principle of relativity (invariance of the laws of motion to a Galilean transformation of coordinates) with its change of viewpoint from one coordinate system to another rarely comes into question in the routine sort of thermodynamic analysis. By analysis of the Joule-Thomson porous-plug experiment under various conditions, it is shown that the standard formalism of thermodynamics is consistent

Ralph J. Tykodi



Careers in the Classics  

ERIC Educational Resources Information Center

America's few Black classics professors have overcome contempt and criticism to contribute a unique perspective to the study of the ancient world. Dr. Patrice Rankine, an associate professor from Purdue University, has grown used to the irony. As one of the few Black classicists teaching at an American university, he has drawn plenty of skepticism…

Lum, Lydia



Classical Mythology. Fourth Edition.  

ERIC Educational Resources Information Center

Designed for students with little or no background in classical literature, this book introduces the Greek and Roman myths of creation, myths of the gods, Greek sagas and local legends, and presents contemporary theories about the myths. Drawing on Homer, Hesiod, Pindar, Vergil, and others, the book provides many translations and paraphrases of…

Morford, Mark P. O.; Lenardon, Robert J.


The Classical Cake Problem  

ERIC Educational Resources Information Center

Discussed are techniques of presentation and solution of the Classical Cake Problem. A frosted cake with a square base is to be cut into n pieces with the volume of cake and frosting the same for each piece. Needed are minimal geometric concepts and the formula for the volume of a prism. (JP)

Nelson, Norman N.; Fisch, Forest N.



Is Electroweak Baryogenesis Classical?  

Microsoft Academic Search

In this lecture first I present a brief genesis of the ideas on the electroweak baryogenesis and then I focus on a mechanism in which the source of $CP$ violation is a $CP$-violating field condensate which could occur, for example, in multi-higgs extensions of the Standard Model. In the limit of a thick bubble wall one finds a classical force

Tomislav Prokopec



Effective classical partition functions  

NASA Astrophysics Data System (ADS)

We present a method by which a quantum-mechanical partition function can be approximated from below by an effective classical partition function. The associated potential is obtained by a simple smearing procedure. For a strongly anharmonic oscillator and a double-well potential, the lowest approximation gives a free energy which is accurate to a few percent, even at zero temperature.

Feynman, R. P.; Kleinert, H.



Classics in What Sense?  

ERIC Educational Resources Information Center

They seem the perfect bookends for the social psychologist's collection of "classics" of the field. Two volumes, nearly identical in shape and weight and exactly a century old in 2008--each professing to usher "social psychology" into the world as they both place the hybrid expression square in their titles but then proceed to stake out the field…

Camic, Charles



Renewing Literary Classics.  

ERIC Educational Resources Information Center

The articles in this journal issue suggest techniques for classroom use of literature that has "withstood the test of time." The titles of the articles and their authors are as follows: (1) "The Storytelling Connection for the Classics" (Mary Ellen Martin); (2) "Elizabeth Bennet: A Liberated Woman" (Geneva Marking); (3) "Hawthorne: A Study in…

Karolides, Nicholas J., Ed.



Hodgkin's Disease and Other Malignant Lymphomas  

PubMed Central

Systematic studies of the patterns of anatomic distribution, pathways of probable spread, and prognosis of the malignant lymphomas have been greatly aided by the development of new histopathologic classifications and the introduction of more sophisticated and precise diagnostic techniques, such as lymphangiography and laparotomy with splenectomy and retroperitoneal node biopsy. Concomitantly, megavoltage radiotherapy apparatus has made total-lymphoid radiotherapy feasible and practical, and the availability of a widening spectrum of chemotherapeutic agents has ushered in a new era of combination chemotherapy. Collectively, these diagnostic and therapeutic advances have already begun to yield a dramatic improvement in the prognosis of Hodgkin's disease and the other malignant lymphomas. ImagesFigure 1.Figure 2.Figure 3.Figure 4.Figure 5.Figure 6.Figure 7.

Rosenberg, Saul A.; Kaplan, Henry S.



Biomarkers in childhood non-Hodgkin's lymphomas.  


Pediatric non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of malignancies with distinct clinical, pathological, immunological and genetic characteristics. More than 90% of pediatric NHLs belong to one of three major histological subtypes: mature B-cell neoplasms, lymphoblastic lymphomas and anaplastic large-cell lymphomas. The recognition that different subtypes require different treatment regimens resulted in therapeutic strategies leading to over 80% of patients being cured. On the other hand, patients with resistant or relapsed disease have a poor prognosis. Prognostic biomarkers have not yet been identified for all pediatric NHLs and, although some are very important for diagnosis and prognosis, others may be of questionable value. Discovery of new biomarkers suitable for clinical application may aid the diagnosis and classification of lymphomas, which should, in turn, lead to better patient stratification. Consequent development of new treatment and follow-up approaches should lead to more efficient and less toxic treatment in children with NHL. PMID:24044571

Dokmanovic, Lidija



Heuristics for the Hodgkin-Huxley system.  


Hodgkin and Huxley (HH) discovered that voltages control ionic currents in nerve membranes. This led them to describe electrical activity in a neuronal membrane patch in terms of an electronic circuit whose characteristics were determined using empirical data. Due to the complexity of this model, a variety of heuristics, including relaxation oscillator circuits and integrate-and-fire models, have been used to investigate activity in neurons, and these simpler models have been successful in suggesting experiments and explaining observations. Connections between most of the simpler models had not been made clear until recently. Shown here are connections between these heuristics and the full HH model. In particular, we study a new model (Type III circuit): It includes the van der Pol-based models; it can be approximated by a simple integrate-and-fire model; and it creates voltages and currents that correspond, respectively, to the h and V components of the HH system. PMID:23219574

Hoppensteadt, Frank



Widespread granuloma annulare and Hodgkin's disease.  


The presence of coexistent disseminated granuloma annulare (GA) and Hodgkin's disease (HD) is rare, with only six reported patients to date. We describe a patient with HD who had limited GA 2 years before the diagnosis of HD; widespread GA appeared after first-line treatment and heralded disease relapse. GA lesions showed hypermetabolic images on positron emission tomography, an interesting finding of unknown significance. We suggest a new pathophysiological mechanism for this association, i.e. that the reactive T-lymphocyte population in HD may contribute to granuloma formation through the secretion of cytokines and the subsequent upregulation of certain metalloproteinases. Diffuse cutaneous GA should raise the possibility of underlying systemic lymphoma or HD. PMID:18462441

Dadban, A; Slama, B; Azzedine, A; Lepeu, G



ALK-Negative Anaplastic Large Cell Lymphoma and Hodgkin’s Disease of Nodular Sclerosing Type in 2 Siblings  

Microsoft Academic Search

Familial clustering of Hodgkin’s disease (HD) and increased risk of developing the disease among the siblings of affected patients suggest that both environmental and genetic factors may play an important role in its pathogenesis. An association between Epstein-Barr virus (EBV) and HD has been widely demonstrated. Recently, latent membrane protein of EBV has also been detected in CD30-positive anaplastic large

Franca Moccia; Elisabetta Tognoni; Piero Boccaccio



GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers  

PubMed Central

Background Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin lymphoma (HL), the aim of this study was to investigate the expression of proteins involved in the regulation of glucose metabolism in the different HL subtypes and their impact on clinical outcome. Methods Lymph node biopsies from 54 HL cases and reactive lymphoid tissue were stained for glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA) and lactate exporter proteins MCT1 and MCT4. In a second series, samples from additional 153 HL cases with available clinical data were stained for GLUT1 and LDHA. Results Membrane bound GLUT1 expression was frequently observed in the tumor cells of HL (49% of all cases) but showed a broad variety between the different Hodgkin lymphoma subtypes: Nodular sclerosing HL subtype displayed a membrane bound GLUT1 expression in the Hodgkin-and Reed-Sternberg cells in 56% of the cases. However, membrane bound GLUT1 expression was more rarely observed in tumor cells of lymphocyte rich classical HL subtype (30%) or nodular lymphocyte predominant HL subtype (15%). Interestingly, in both of these lymphocyte rich HL subtypes as well as in progressively transformed germinal centers, reactive B cells displayed strong expression of GLUT1. LDHA, acting downstream of glycolysis, was also expressed in 44% of all cases. We evaluated the prognostic value of different GLUT1 and LDHA expression patterns; however, no significant differences in progression free or overall survival were found between patients exhibiting different GLUT1 or LDHA expression patterns. There was no correlation between GLUT1 expression in HRS cells and PET standard uptake values. Conclusions In a large number of cases, HRS cells in classical HL express high levels of GLUT1 and LDHA indicating glycolytic activity in the tumor cells. Although interim-PET is an important prognostic tool, a predictive value of GLUT1 or LDHA staining of the primary diagnostic biopsy could not be demonstrated. However, we observed GLUT1 expression in progressively transformed germinal centers and hyperplastic follicles, explaining false positive results in PET. Therefore, PET findings suggestive of HL relapse should always be confirmed by histology.



Classical Language Instruction Project  

NSDL National Science Digital Library

Developed by Christian Wildberg at Princeton University, the Classical Language Instruction Project is designed to function as a resource for college undergraduates hoping to gain some insight into the pronunciation and elocution of ancient Greek and Latin. As the rationale for the Project states on the site: "There may be considerable debate among scholars about the most 'authentic' way to pronounce Greek or Latin; yet it is certain that the texts from the ancient world reflect a vivid and complex spoken language, not a lifeless code." With that in mind, the site features different classical scholars reading passages by a number of writers, including Homer, Plato, Virgil, Horace, Ovid, and Seneca. As the scholars read, students can follow along, view the passage in English, and pause the recording in order to develop an understanding of the text and its pronunciation. Finally, the site also includes a brief essay on rhythm and meter in Greek and Latin.


Classical direct interstring action  

Microsoft Academic Search

We generalize the classical action-at-a-distance theory between point particles to include one-dimensionally extended objects (strings) in space-time. We build parametrization-invariant couplings which lead to equations of motion for strings in each others' influence. The direct coupling of the area elements of the world sheets of the strings is considered in detail, from which we define an antisymmetric adjunct field. We

Michael Kalb; P. Ramond



Revisiting a Classic  

ERIC Educational Resources Information Center

As a 26-year-old English teacher in 1958, Chinua Achebe had no idea that the book he was writing would become a literary classic, not only in Africa but also throughout the world. He could only try to articulate the feelings he had for his countrymen and women. Achebe had a burning desire to tell the true story of Africa and African humanity. The…

Rogers, Ibram



What's New in Research and Treatment of Non-Hodgkin Lymphoma in Children?  


... resources for non-Hodgkin lymphoma in children What’s new in research and treatment of non-Hodgkin lymphoma ... further treatment is not given. Clinical trials of new treatments Most children with NHL are treated at ...


IMP3 as a supplemental diagnostic marker for Hodgkin lymphoma.  


Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is ubiquitously expressed in embryos, mediating organogenesis, RNA trafficking, and cell growth, and is generally down-regulated in adult tissue. However, IMP3 has recently been shown to be overexpressed in some malignant epithelial neoplasms and to be a useful diagnostic and/or prognostic biomarker for several carcinomas. To determine whether IMP3 might also be an accurate biomarker of Hodgkin lymphoma, we examined 81 Hodgkin lymphomas for immunoreactivity to IMP3 as compared to commonly used markers such as CD30, CD15, PAX5, and MUM1. Consequently, in 98.8% (80/81) of Hodgkin lymphomas, the malignant Hodgkin and Reed-Sternberg cells were selectively reactive for IMP3, with 72.8% (59/81) of the tumors showing strong, diffuse cytoplasmic staining. Positive staining of the Hodgkin lymphomas was also seen for CD30 (82.7%, 67/81), CD15 (65.4%, 53/81), PAX5 (84.0%, 68/81), and MUM1 85.2% (69/81), but significantly fewer cells showed strong staining intensity for CD30 (32.1%, 26/81), CD15 (17.3%, 14/81), PAX5 (12.3%, 10/81), and MUM1 (29.6%, 24/81). Furthermore, the IMP3 staining was selectively restricted to Hodgkin and Reed-Sternberg cells, with a clearly negative background, and complementary to CD30 staining. Our findings show that IMP3 may be a useful diagnostic marker of Hodgkin lymphoma, helping to improve diagnostic accuracy for this malignancy. PMID:23845468

Tang, Hongping; Wei, Qingzhu; Ge, Juan; Jian, Wenjing; Liu, Jiangchuan; Zhong, Lin; Fu, Bo; Zhao, Tong



Automated parameter estimation of the Hodgkin-Huxley model using the differential evolution algorithm: application to neuromimetic analog integrated circuits.  


We propose a new estimation method for the characterization of the Hodgkin-Huxley formalism. This method is an alternative technique to the classical estimation methods associated with voltage clamp measurements. It uses voltage clamp type recordings, but is based on the differential evolution algorithm. The parameters of an ionic channel are estimated simultaneously, such that the usual approximations of classical methods are avoided and all the parameters of the model, including the time constant, can be correctly optimized. In a second step, this new estimation technique is applied to the automated tuning of neuromimetic analog integrated circuits designed by our research group. We present a tuning example of a fast spiking neuron, which reproduces the frequency-current characteristics of the reference data, as well as the membrane voltage behavior. The final goal of this tuning is to interconnect neuromimetic chips as neural networks, with specific cellular properties, for future theoretical studies in neuroscience. PMID:21671785

Buhry, Laure; Grassia, Filippo; Giremus, Audrey; Grivel, Eric; Renaud, Sylvie; Saïghi, Sylvain



Clinical Significance of Soluble CD30 Antigen in the Sera of Patients With Untreated Hodgkin's Disease  

Microsoft Academic Search

The soluble form of the CD30 antigen (sCD30). an 88-Kd glycoprotein that is released by Hodgkin's-derived cell lines in vitro, can be detected in patients with Hodgkin's lym- phoma, adult (HTLV-1') T-cell leukemia, rare cases of non- Hodgkin's lymphoma, and acute infectious mononucleosis (anti-EBV-IgM'). In a prospective study of 90 consecutive untreated patients with newly diagnosed Hodgkin's disease who were

Angela Gause; Christoph Pohl; Astrid Tschiersch; Ligia Da Costa; Wolfram Jung; Volker Diehl; Dirk Hasenclever; Michael Pfreundschuh


Whole-body FDG-PET imaging for staging of Hodgkin`s disease and lymphoma  

SciTech Connect

Accurate staging of Hodgkin`s disease (HD) and non-Hodgkin`s lymphoma (NHL) is important for treatment management. In this study, the utility of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) wholebody PET was evaluated as an imaging modality for initial staging or restaging of 7 HD and 11 NHL patients. Whole-body PET-based staging results were compared to the patient`s clinical stage based on conventional staging studies, which included combinations of CT of the chest, abdomen and pelvis, MRI scans, gallium scans, lymphangiograms, staging laparatomies and bone scans. Accurate staging was performed in 17 of 18 patients using a whole-body PET-based staging algorithm compared to the conventional staging algorithm in 15 of 18 patients. In 5 of 18 patients, whole-body PET-based staging showed additional lesions not detected by conventional staging modalities, whereas conventional staging demonstrated additional lesions in 4 of 18 patients not detected by whole-body PET. The total cost of conventional staging was $66,292 for 16 CT chest scans, 16 CT abdominal/pelvis scans, three limited MRI scans, four bone scans, give gallium scans, two laparotomies and one lymphangiogram. In contrast, scans cost $36,250 for 18 whole-body PET studies and additional selected correlative studies: one plain film radiograph, one limited CT, one bone marrow san, one upper GI and one endoscopy. A whole-body FDG-PET-based staging algorithm may be an accurate and cost-effective method for staging or restaging HD and NHL. 10 refs., 7 figs., 2 tabs.

Hoh, C.K.; Glaspy, J.; Rosen, P. [Crump Institute of Biological Imaging, Los Angeles, CA (United States)] [and others



Circulating tumor cells in Hodgkin's lymphoma - a review of the spread of HL tumor cells or their putative precursors by lymphatic and hematogenous means, and their prognostic significance.  


About 15% of patients diagnosed with classical Hodgkin's lymphoma (cHL) are considered high risk with unfavorable prognosis. The biology of the disease bears a direct relationship to its clinical course. However, some aspects of the disease are still being debated. Related topics include origin of neoplastic cells as circulating precursor versus germinal center B cell, and disease metastasis via hematogenous routes and the effect of HL circulation on relapse potential and further spread of the disease. The terminally differentiated giant neoplastic Hodgkin Reed-Sternberg (HRS) cells (HRSC) have limited proliferation and lack mobility. Therefore, they are unable to penetrate epithelium. Thus, the clinical aggressiveness of HRSCs that disseminate via both lymphatic and hematogenous may be determined by their molecular composition. This review discusses in detail the historical perspectives on scientific and clinical evidences of precursors of circulating HL cells and the prognostic importance of these circulating cells for predicting outcome. PMID:24176672

Gharbaran, Rajendra; Park, Jongwhan; Kim, Chris; Goy, A; Suh, K Stephen



Chinese Air Quality  

Chinese Air Quality Project Title:  GTE Discipline:  ... Aerosols Platform:  Ground based Instrument:  in situ Location:  North Western Pacific ... Web Access:  Data Pool Parameters:  Air Pollution Index Order Data:  Data Pool:  Order Data ...



Chinese Medical Literature.  

National Technical Information Service (NTIS)

Contents: High tibial osteotomy; An investigation of digoxin radioimmunoassay; Comparative studies on the absorption, distribution and excretion of 14C-gossypol in 4 animal species; Maldimelsu antimicrobial activities; Pharmacognostic study of the Chinese...



Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia



Psychiatry and Chinese Culture  

PubMed Central

When we examine the cultural characteristics that influence mental disorders and related behavior among the Chinese, no major differences are found between Chinese and other groups in the range of disorders or in overall prevalence. Several cultural factors influence the recognition and treatment of mental illness, among which are attitudes toward emotional display, somatic as opposed to psychogenic disorders and features of the traditional medical belief system in Chinese culture. The Chinese have a relatively favorable prognosis of schizophrenia, low rates of depressive illness, a strong tendency towards somatization and the presence of several unique culture-bound syndromes. From studying Chinese in Vancouver, it was found that they have a characteristic way of dealing with mental illness in the family, in that there is first a protracted period of intrafamilial coping with serious psychiatric illness, followed by recourse to friends, elders and neighbors in the community; third, consultation with traditional specialists, religious healers or general physicians; fourth, outpatient or inpatient treatment from specialists, and, finally, a process of rejection and scapegoating of the patient. The efficacy of Western psychiatric treatment of Chinese patients has yet to be objectively assessed.

Lin, Tsung-Yi



Classical Nernst engine  

NASA Astrophysics Data System (ADS)

We introduce a simple model for an engine based on the Nernst effect. In the presence of a magnetic field, a vertical heat current can drive a horizontal particle current against a chemical potential. For a microscopic model invoking classical particle trajectories subject to the Lorentz force, we prove a universal bound 3-2?2 ?0.172 for the ratio between the maximum efficiency and the Carnot efficiency. This bound, as the slightly lower one 1/6 for efficiency at maximum power, can indeed be saturated for a large magnetic field and small fugacity.

Stark, Julian; Brandner, Kay; Saito, Keiji; Seifert, Udo



Classic Slide Rule  

NSDL National Science Digital Library

In this activity, students construct classic slide rules and use them like calculators. Students use the slide rules to read scales, determine significant figures, and estimate decimal places.  This is activity D3 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure, compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi.


Hodgkin's Lymphoma Therapy: Past, Present, and Future  

PubMed Central

Importance of the field The treatment of Hodgkin lymphoma (HL) with the use of radiotherapy and systemic chemotherapy has been one of the success stories of modern oncology. HL therapy has been the paradigm for the systematic evaluation of different curative modalities resulting in cure for the majority of patients. The current focus is on designing initial therapeutic strategies which retain efficacy and minimize long-term toxicity. Appropriate use of pathologic, clinical, biologic and radiologic prognostic factors in identification of aggressive HL is paramount in designing a successful therapeutic strategy. Areas covered in this review This review addresses the current and future use of prognostic tools, including PET scanning and other biomarkers, in identifying patients with aggressive HL with reference to publications from the last two decades. The current standard approaches with the use of combined modality therapy and systemic chemotherapy as well as the promising role of future response-adapted strategies is reviewed. What the reader will gain The reader will obtain a comprehensive review of risk assessment strategies as well as current and investigational therapeutic approaches in the management of HL. Take home message In HL, appropriate utilization of risk assessment strategies is required to maximize therapeutic outcomes while minimizing toxicity, especially long-term toxicity. Response-adapted therapy utilizing PET has the potential to profoundly improve the therapeutic landscape in HL.

Kadin, M; Rathore, B



Fertility preservation after chemotherapy for Hodgkin lymphoma.  


Treatment for Hodgkin lymphoma can negatively affect fertility. This review summarizes data on fertility after chemotherapy in adult patients. Alkylating chemotherapy, especially if containing procarbazine and/or cyclophosphamide, is most harmful to gonadal functioning. Alkylating regimens cause prolonged azoospermia in 90-100% of men and ovarian failure in 5-25% of women under the age of 30. Non-alkylating chemotherapy, like ABVD, is much less harmful: one-third of male patients develop transient azoospermia, and almost no female patients experience ovarian failure. Age is an important factor for women: females over 30 years have a much higher risk of acute ovarian failure. However, with long-term follow-up the cumulative risk of menopause before the age of 40 becomes the same irrespective of treatment age. In males, semen cryopreservation before start of treatment should be offered to all (post)pubertal patients. For females with a partner, IVF followed by embryo cryopreservation is a widely available method, but this necessitates postponement of lymphoma therapy for at least a month. Oocyte cryopreservation and ovarian tissue cryopreservation are experimental techniques showing great promise. GnRH-analogues are being investigated as possible means to preserve fertility in women, but effectiveness has not yet been proven conclusively. PMID:20232475

van der Kaaij, Marleen A E; van Echten-Arends, Jannie; Simons, Arnold H M; Kluin-Nelemans, Hanneke C



Autologous bone marrow transplantation in Hodgkin's disease.  


The outcome of advanced Hodgkin's disease has improved since the use of MOPP and ABVD. However 50% of these patients will relapse. Conventional salvage therapy can yield a complete response rate of 50%. However, only 5 to 30 percent can expect to be cured. Autologous bone marrow (ABMT) in reported publications can reach 50 to 80% remission rate in refractory patients with a disease free survival of 40 to 80%. Adverse prognostic factors are: tumor burden, number of prior chemotherapies, response to latest therapy and performance status. At the present time, ABMT is discussed in relapse of poor prognosis with initially stage I to IIIA. Twenty-six patients underwent ABMT at Saint-Louis Hospital. Fifteen were sensitive relapses of poor prognosis, 11 initially refractory disease. After ABMT, 19 were in complete remission including 14 relapses. Disease free survival was 80% for relapsing patients, again 50% for refractory patients (P = 0.001). ABMT should be a tool for refractory patients and relapses of poor prognosis. PMID:2190180

Gisselbrecht, C; Brice, P; Lepage, E; Brichon, P; Gerota, J; Boiron, M



Advances in the treatment of Hodgkin lymphoma.  


In the past decades, Hodgkin lymphoma (HL) has turned from an incurable disease to one with the most favorable prognosis among adult malignancies. This is due to the introduction of effective multi-agent chemotherapy and the optimization of radiation techniques. At present, 80-90 % of patients achieve long-term remission when receiving appropriate first-line treatment. Even in case of relapse, up to 50 % can be successfully salvaged with high-dose chemotherapy and autologous stem cell transplantation. Thus, current studies do not necessarily aim at increasing treatment efficacy but rather focus on a possible reduction of acute and late toxicity by decreasing treatment intensity if possible. One promising strategy to spare therapy in good-risk patients is early response-adapted treatment stratification according to the result of interim positron emission tomography. The evaluation of novel drugs and the optimization of treatment for elderly HL patients and those with nodular lymphocyte-predominant HL are further aspects that are currently being addressed in ongoing trials. This review will give an overview on more recent clinical trials and discuss possible future strategies for the treatment of HL. PMID:23054655

Eichenauer, Dennis A; Engert, Andreas



Paraneoplastic autoimmune cytopenias in Hodgkin lymphoma.  


Autoimmune cytopenias are typical paraneoplastic phenomena in malignant lymphomas. We assessed the occurrence, clinical, and laboratory features as well as the response to treatment of autoimmune hemolytic anemia, autoimmune thrombocytopenia, and neutropenia in published cases of Hodgkin lymphomas (HL). We identified 34 cases of an association between HL and autoimmune hemolytic anemia and 48 cases of an association of autoimmune thrombocytopenia (AITP) and HL. The autoimmune cytopenias (AIC) may occur prior to, concurrent with, at the time of recurrence of lymphoma or in complete remission after treatment. Almost all autoimmune hemolytic anemias were caused by warm antibodies. Patients with HL with AIC are more commonly males and are more likely to have mixed cellularity (MC) HL. HL is the only lymphoma which may be associated with autoimmune neutropenia. In contrast to AIC in diffuse large B-cell lymphoma (DLBCL), early stage is less common in patients with HL with AIC. AIC in HL respond better to antilymphoma treatment than to steroids, with the exception of post-treatment AITP in CR of HL which responds easily and durably to steroids. PMID:20141438

Lechner, Klaus; Chen, Yen-An



Diet and non-Hodgkin's lymphoma risk  

PubMed Central

Background The role of dietary factors in the epidemiology of Non-Hodgkin's lymphoma (NHL) remains largely undefined. Dietary habits may play a role in the etiology of NHL by influencing the immune system. Methods Dietary patterns and the risk of NHL were analyzed in a case control study; including 170 NHL cases and 190 controls. All subjects completed a validated food-frequency questionnaire. The dietary pattern was investigated separately and in nine nutritional groups. Crosstab tables were used to estimate the odds ratios (OR), and Ptrend. Results Consumption of highest versus lowest quartile of proteins (OR, 8.088 Ptrend=0.000), fats (OR, 6.17 Ptrend=0.000) and sweets (OR, 8.806 Ptrend=0.000) were associated with a significantly increased NHL risk. The inverse association was found for fresh fruits (OR, 0.117 Ptrend=0.000) and vegetables (OR, 0.461 Ptrend=0.010). Conclusion An association between dietary intake and the risk of NHL is biologically plausible due to immunosuppressive effects of fat and animal proteins, and antioxidant properties of vegetables and fruits.

Mozaheb, Zahra; Aledavood, Amir; Farzad, Farzaneh



Aurora B kinase in Hodgkin lymphoma: immunohistochemical pattern of expression in neoplastic Hodgkin and Reed-Sternberg cells.  


Aurora B is a member of the chromosomal passenger complex, which is essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge there are extremely limited studies investigating the immunohistochemical expression of Aurora B in tumor specimens of Hodgkin lymphoma. Our purpose was to characterize the expression of Aurora B in biopsies of Hodgkin lymphomas, and to evaluate the pattern of immunoreactivity in neoplastic Hodgkin and Reed-Sternberg cells (RS cells). We examined Aurora B immunoreactivity in paraffin sections of 15 samples of Hodgkin lymphomas, obtained from 15 patients, 8 men and 7 women. Ten were of nodular sclerosis type and five were of mixed cellularity. Our results showed immunoexpression of Aurora B in mononuclear lymphoid cells as well as in bi- and multinucleated RS cells. In addition, positive neoplastic cells in mitosis were observed, whereas a subpopulation without evidence of immunoreaction was also detected in each case. Taken together our results point to a possible association between Aurora B expression and mitotic deregulation in Hodgkin lymphoma, which may provide novel targets for treatment. PMID:24366835

Ioannou, M; Kouvaras, E; Stathakis, E; Samara, M; Koukoulis, G K



Role of Radiotherapy in Modern Treatment of Hodgkin's Lymphoma  

PubMed Central

Hodgkin's Lymphoma was incurable until the advent of effective therapeutic radiation around the first half of the 20th century. As survival rates improved, the long-term toxicities from radiotherapy began to emerge. This together with the availability of effective chemotherapy has encouraged a combined modality approach for early-staged disease and the omission of radiotherapy in advanced-staged disease. The differing toxicities of radiotherapy and chemotherapy has promoted ongoing research to identify the utility of each of these modalities in the modern management of Hodgkin's Lymphoma. This article will provide a critical review of the developments and indications for modern radiotherapy, in context with advances in chemotherapy, for the treatment of Hodgkin's Lymphoma.

Yeoh, Kheng-Wei; Mikhaeel, N. George



Analysis of antigen receptor genes in Hodgkin's disease.  

PubMed Central

AIM--To analyse the configuration of the antigen receptor genes in Hodgkin's disease. METHODS--DNA extracted from 45 samples of Hodgkin's disease was analysed using Southern blotting and DNA hybridisation, using probes to the joining region of the immunoglobulin heavy chain gene, the constant region of kappa immunoglobulin light chain gene, and the constant region of the beta chain of the T cell receptor gene. RESULTS--A single case of nodular sclerosing disease showed clonal rearrangement of the immunoglobulin heavy and light chain genes, all other samples having germline immunoglobulin genes. The nature of the clonal population in the diseased tissue is uncertain, because the intensity of the rearranged bands did not correlate with the percentage of Reed-Sternberg cells present. The T cell receptor genes were in germline configuration in all the samples. CONCLUSIONS--Antigen receptor gene rearrangement is a rare finding in unselected cases of Hodgkin's disease. Images

Angel, C A; Pringle, J H; Naylor, J; West, K P; Lauder, I



Hodgkin lymphoma untreated for six years presenting with tracheoesophageal fistula.  


Hodgkin lymphoma is a highly curable cancer with modern therapy, with five-year survival rates in excess of 80%. However, the natural history of the untreated disease is largely unknown. We present the case of a patient with Hodgkin lymphoma who went untreated for over 5 years due to patient choice. Eventually, the patient developed hypoxemia, significant weight loss, and a tracheoesophageal fistula. After a placement of a gastrostomy tube and tracheal stent, treatment with standard chemotherapy was initiated. The patient achieved an excellent response, the fistula closed without further intervention, and there is no evidence of relapse six years later. Even in a patient with significant Hodgkin-lymphoma-related sequelae, standard therapy can result in excellent long-term outcomes. PMID:22811723

Westin, Jason R; Gibbs, Amye; Mills, Keith R; Neelapu, Sattva S



Primary non-Hodgkin's lymphoma of the gall bladder.  


Primary non-Hodgkin lymphoma of the gallbladder is a very rare location of extranodal non-Hodgkin lymphomas. A patient with a primary non-Hodgkin lymphoma of the gallbladder is reported and in addition, the English literature is reviewed. Clinical presentation, diagnostic evaluation, histopathologic findings, treatment modalities and prognosis of primary gallbladder lymphomas reported up to date are reviewed and discussed. Our patient was diagnosed as a T-cell lymphoblastic lymphoma, after cholecystectomy, and had no evidence of disease elsewhere. She was treated with combination chemotherapy and complete remission was achieved. She remains free of disease 9 years later. Review of the literature over a 30-year period revealed only 12 cases of well-documented primary non-Hodgkin lymphoma involvement of the gallbladder, including the present case. Patients present clinically with symptoms and signs indicating either biliary tract pathology or a gastrointestinal tumor. Diagnostic investigation included ultrasound of the upper abdomen, computed tomography of the abdomen and pelvis, oral cholecystography, percutaneous cholangiography and endoscopic retrograde cholangiopangreatography. Preoperative diagnosis was established in none of the patients. Treatment modalities included surgery and postoperative chemotherapy and irradiation. The prognosis is overall poor and only 2 patients are alive after 1 and 9 years respectively, the latter being our case. Here we document the first reported case of a patient with primary T-cell lymphoblastic non-Hodgkin lymphoma of the gallbladder. Review of the literature shows the existence of non-Hodgkin lymphoma of the gallbladder, its rarity and its general dismal prognosis. PMID:11426613

Mitropoulos, F A; Angelopoulou, M K; Siakantaris, M P; Rassidakis, G; Vayiopoulos, G A; Papalampros, E; Kalovidouris, A; Pangalis, G A



Is it Harder to Parse Chinese, or the Chinese Treebank?  

Microsoft Academic Search

We present a detailed investigation of the challenges posed when applying parsing models developed against English corpora to Chinese. We develop a factored-model statistical parser for the Penn Chinese Treebank, showing the implications of gross statistical differences between WSJ and Chinese Tree-banks for the most general methods of parser adaptation. We then provide a detailed analysis of the major sources

Roger Levy; Christopher D. Manning



Classical versus quantum coherence.  


Quantum dots are structures engineered to have desirable quantum-mechanical properties. Much of their potential usefulness stems from the ability to design such structures so that their passive properties can be exploited. However, there are many plans to use dots as the basis of a more active quantum engineering, in which the detailed quantum states of the dot's components are manipulated by externally imposed fields. This leads to a new requirement: our ability to model the time development of individual driven quantum systems. I shall discuss some of the problems which arise when single systems, rather than ensembles, are considered and give examples which illustrate the effects of classical and quantum incoherences. I propose a new classification of incoherent processes, based on their effect on individual wave functions. PMID:12639390

Greenland, P T



Access Excellence Classic Collection  

NSDL National Science Digital Library

Another good resource from is the Activities Exchange Classic Collection Web site. The page presents links that focus on a single person or event by putting it into historical context and relating it to current science. Each contains a set of references, classroom activities, graphics, background information, and more. Some of the titles of the activities include The Discovery Of Radioactivity: The Dawn of the Nuclear Age; Radioactivity: Historical Figures; How We See: The First Steps of Human Vision; Discovery, Chance, and the Scientific Method; DNA Structure; and Development of Polio Vaccines. The pages and activities are well designed and offer educators some interesting and unique lessons for their students.


Lymphome de Hodgkin: traitement des stades localisés sus-diaphragmatiques  

Microsoft Academic Search

\\u000a Abstract  The risk-adapted therapeutic strategy used for adult patients with Hodgkin’s lymphoma is defined taking into account their\\u000a risk factors and includes standard first-line ABVD chemotherapy. In early-stage supradiaphragmatic disease, 3 chemotherapeutic\\u000a courses are applied for patients without risk factors while 4 courses are used for patients with risk factors, followed by\\u000a a radiation therapy targeting initially involved fields (IFRT) at

C. Fermé



Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma  

PubMed Central

A combination of Adriamycin (a.k.a. Doxorubicin), Bleomycin, Vinblastine, and Dacarbazine (ABVD) is the most commonly used chemotherapy regime for Hodgkin lymphoma. This highly effective treatment is associated with a significant risk of neutropenia. Various strategies are adopted to counter this commonly encountered problem, including dose modification, use of colony stimulating factors, and prophylactic or therapeutic use of antibiotics. Data to support these approaches is somewhat controversial, and in keeping with the paucity of definitive evidence, there is a wide disparity in the management of neutropenia in patients receiving ABVD chemotherapy. This paper summarizes the evidence for managing ABVD-related neutropenia during the treatment of Hodgkin lymphoma.

Vakkalanka, Bhanu; Link, Brian K.



Hodgkin's disease with hypercalcemia detected by thallium-201 scintigraphy  

SciTech Connect

A 53-yr-old man with hypercalcemia was referred after an unsuccessful operative attempt to find a parathyroid adenoma. Metabolic evaluation showed relatively suppressed levels of parathyroid hormone with an elevation of serum 1,25-dihydroxyvitamin D. Thallium-technetium dual isotope imaging revealed localized mediastinal thallium uptake. A vascular mediastinal lesion was then demonstrated by arteriography, with subsequent surgical removal of a mass that proved to be lymphocyte predominant Hodgkin's disease. This case is noteworthy for the finding of isolated lymphocyte predominant Hodgkin's disease in the chest, the association of elevated serum 1,25-dihydroxyvitamin D with hypercalcemia that resolved postoperatively, and the uptake of thallium by the tumor.

Linde, R.; Basso, L.



The Evolving Role of Radiotherapy in Early Stage Hodgkin's Lymphoma  

PubMed Central

Radiation therapy has a key role in the combined modality treatment of early-stage Hodgkin’s Lymphoma (HL). Nevertheless, late toxicity still remains an issue. A modern approach in HL radiotherapy includes lower doses and smaller fields, together with the implementation of sophisticated and dedicated delivery techniques. Aim of the present review is to discuss the current role of radiotherapy and its potential future developments, with a focus on major clinical trials, technological advances and their repercussion in the clinical management of HL patients.

Ricardi, Umberto; Filippi, Andrea Riccardo; Piva, Cristina; Franco, Pierfrancesco



Ancient Chinese Astronomical Technologies  

NASA Astrophysics Data System (ADS)

I am interested in the astronomical advances of the Ancient Chinese in measuring the solar day. Their development of gnomon & ruler, sundial, and water clock apparatuses enabled Chinese astronomers to measure the annual solar orbit and solar day more precisely than their contemporaries. I have built one of each of these devices to use in collecting data from Olympia, Washington. I will measure the solar day in the Pacific Northwest following the methodology of the ancient Chinese. I will compare with my data, the available historical Chinese astronomical records and current records from the United States Naval Observatory Master Clock. I seek to understand how ancient Chinese investigations into solar patterns enabled them to make accurate predictions about the movement of the celestial sphere and planets, and to develop analytic tests of their theories. Mayall, R. Newton; Sundials: their construction and use. Dover Publications 2000 North, John; The Norton History of Astronomy and Cosmology W.W. Norton& Co. 1995 Zhentao Xu, David W. Pankenier, Yaotiao Jiang; East Asian archaeoastronomy : historical records of astronomical observations of China, Japan and Korea Published on behalf of the Earth Space Institute by Gordon and Breach Science Publishers, c2000

Walsh, Jennifer Robin



Fibroblast growth factor receptor 4 polymorphisms and the prognosis of non-Hodgkin lymphoma.  


Fibroblast growth factors and their receptors (FGFRs) play important roles in blood system. FGFR4 rs351855 (Gly388Arg) polymorphism has shown to be a risk factor for many diseases. The aim of this study was to investigate the association between FGFR4 polymorphisms and the susceptibility to non-Hodgkin lymphoma (NHL) in the Chinese population. We identified two polymorphisms in the FGFR4 gene, rs351855G/A (Gly388Arg), and rs147603016G/A, by polymerase chain reaction-restriction fragment length polymorphism in 412 NHL cases and 476 healthy controls. Results showed that frequencies of AA genotype and A allele in rs351855 (Gly388Arg) polymorphism were significantly higher in patients than in controls (odds ratio (OR) 2.12, 95 % confidence intervals (CI) 1.99-3.48, P < 0.0001; OR 1.45, 95 % CI 1.21-1.88, P < 0.0001, respectively; data were adjusted for age and sex). The rs147603016G/A polymorphism did not show any correlation with NHL. When analyzing the survival time of NHL patients with FGFR4 rs351855G/A polymorphism, cases with AA genotype had significantly shorter survival time compared to the patients with GG and GA genotypes (P = 0.002). These results suggested polymorphism in FGFR4 gene was associated with increased susceptibility to NHL and could be used as a prognostic marker for this malignancy. PMID:24381107

Cha, Zhanshan; Zang, Yan; Guo, Huijun; Gu, Haihui; Tu, Xiaohua; Song, Haihan; Qian, Baohua



Quantum Computing's Classical Problem, Classical Computing's Quantum Problem  

NASA Astrophysics Data System (ADS)

Tasked with the challenge to build better and better computers, quantum computing and classical computing face the same conundrum: the success of classical computing systems. Small quantum computing systems have been demonstrated, and intermediate-scale systems are on the horizon, capable of calculating numeric results or simulating physical systems far beyond what humans can do by hand. However, to be commercially viable, they must surpass what our wildly successful, highly advanced classical computers can already do. At the same time, those classical computers continue to advance, but those advances are now constrained by thermodynamics, and will soon be limited by the discrete nature of atomic matter and ultimately quantum effects. Technological advances benefit both quantum and classical machinery, altering the competitive landscape. Can we build quantum computing systems that out-compute classical systems capable of some 10^{30} logic gates per month? This article will discuss the interplay in these competing and cooperating technological trends.

Van Meter, Rodney



Three cases demonstrating the role of gallium scanning in relapsing Hodgkin's disease and non-Hodgkin lymphoma  

SciTech Connect

Restaging of Hodgkin's disease and non-Hodgkin lymphoma for chemotherapy traditionally requires chest radiograph and abdominal computerized tomogram (CT) for routine follow-up examination. Although gallium scanning has had a poor record in the past, recent studies suggest that improved techniques have given this method high sensitivity. We present three cases in which gallium correctly staged lymphoma that had been missed or misinterpreted by chest radiographs and abdominal CT. Gallium imaging is useful in follow-up of lymphoma patients especially when the CT scan is difficult to interpret.

Zollars, L.E.; Nagel, J.S.; Tumeh, S.S.



Health Information in Chinese - Simplified (????): MedlinePlus  


... ???? (Chinese - Simplified) Bilingual PDF Health Information Translations Female Exam and Pap Smear ????????? - ???? (Chinese - Simplified) ... PDF Chinese Community Health Resource Center Urine Sample -- Female (Clean Catch) ??-??(?????) - ???? (Chinese - Simplified) ...


RS3PE revealing recurrent non-Hodgkin's lymphoma.  


A patient meeting published criteria for remitting seronegative symmetrical synovitis with pitting edema (RS3PE) was found to have a synchronous recurrence of non-Hodgkin's malignant lymphoma. Reported cases of RS3PE associated with hematological malignancies and other forms of cancer are reviewed. PMID:15474395

Gisserot, Olivier; Crémades, Serge; Landais, Cécile; Leyral, Guénaelle; Bernard, Philippe; de Jauréguiberry, Jean-Pierre



RS3PE revealing recurrent non-Hodgkin’s lymphoma  

Microsoft Academic Search

A patient meeting published criteria for remitting seronegative symmetrical synovitis with pitting edema (RS3PE) was found to have a synchronous recurrence of non-Hodgkin’s malignant lymphoma. Reported cases of RS3PE associated with hematological malignancies and other forms of cancer are reviewed.

Olivier Gisserot; Serge Crémades; Cécile Landais; Guénaelle Leyral; Philippe Bernard; Jean-Pierre de Jauréguiberry



Novel Drug Effectively Shrinks Tumors in Hodgkin Lymphoma

An investigational drug composed of a monoclonal antibody linked to a potent chemotherapy agent led to complete or substantial tumor shrinkage in nearly 40 percent of patients with Hodgkin lymphoma in a phase I clinical trial, researchers reported November 4, 2010, in the New England Journal of Medicine.


Trial Suggests New Treatment Option for Hodgkin Lymphoma

Intermediate results from a phase II clinical trial presented at the 2010 American Society of Hematology annual meeting indicate that an investigational agent called brentuximab vedotin may be an effective alternative for some patients with Hodgkin lymphoma who have few viable treatment options.


Histopathology and clinical problems in non-hodgkin lymphomas  

Microsoft Academic Search

Even though there is still no definitive evidence for the nature of the neoplastic cells in Hodgkin's disease, recent years have shown considerable progress in the management of patients with this condition. These advances are largely due to the worldwide acceptance of a histopathological classification and a clinical staging scheme based on the characteristics of disease extension which made possible

G. Brittinger



Incidence of homogeneously staining regions in non-Hodgkin lymphomas  

Microsoft Academic Search

We report a series of 86 non-Hodgkin's lymphomas (NHL) studied cytogenetically in which two cases with a homogeneously staining region (HSR) located on chromosome 19 and on chromosome 1, respectively, were observed. The low incidence detected (2.3%) suggests that HSR are rare events in NHL. An oncogenetic amplification study was performed with probes for genes that are currently known to

E. Arranz; M. Robledo; B. Martínez; J. Gallego; A. Román; C. Rivas; J. Benítez



Survivors of Hodgkin Lymphoma May Face Increased Risk of Stroke

Patients who receive radiation therapy for Hodgkin lymphoma may be at increased risk of a stroke or transient ischemic attack (TIA), also called a "mini stroke," later in life, according to a report in the July 1, 2009, Journal of the National Cancer Institute.


Bendamustine in the treatment of non-Hodgkin's lymphomas  

PubMed Central

Purpose: To review available data using bendamustine alone and in combination with other chemotherapeutic agents in treatment of patients with non-Hodgkin’s lymphomas. Methods: Internet database searches and literature review. Results: Bendamustine was approved in March 2008 by the United States Food and Drug Administration for the treatment of patients with chronic lymphocytic leukemia. Many trials have been performed over the last decade using bendamustine not only as monotherapy, but also in combination with other agents including rituximab, vincristine, mitoxantrone, fludarabine, and other agents as therapy for patients with relapsed non-Hodgkin’s lymphomas, and recently was approved for use in therapy of patients with relapsed indolent lymphomas considered refractory to rituximab therapy. As monotherapy, bendamustine induces good responses with only minor side effects. In combination with other agents, efficacy improves, especially when given in combination with rituximab. The drug has also been studied in combination with rituximab as initial therapy for indolent lymphomas, and has excellent activity with less toxicity than R-CHOP (rituximab – cyclophosphamide, hydroxydaunorubicin [Adriamycin], Oncovin [vincristine], and prednisone/prednisolone). Conclusion: Overall, bendamustine has demonstrated promising results as therapy for non-Hodgkin’s lymphomas and should be included in the armamentarium of agents used to treat relapsed indolent non-Hodgkin’s lymphomas and may prove valuable as initial therapy for these diseases. Further studies are being conducted to demonstrate the efficacy of this drug in combination with other agents.

Hagemeister, Fredrick; Manoukian, George



Chorea as a paraneoplastic complication of Hodgkin's disease  

Microsoft Academic Search

Neurologic complications of Hodgkin's disease (HD) include both metastatic and non-metastatic involvement of the nervous system. There are at least five paraneoplastic syndromes associated with HD but chorea has not been described. We report the first choreiform disorder as a paraneoplastic complication of HD and only the second case of paraneoplastic chorea in the literature.

T. T. Batchelor; M. Platten; D. E. Palmer-Toy; G. J. Hunter; M. H. Lev; J. Dalmau; F. H. Hochberg



Subacute cutaneous lupus erythematosus associated with Hodgkin's disease  

Microsoft Academic Search

Summary Simultaneous occurrence of subacute cutaneous lupus erythematosus and malignancy has rarely been reported. We report the first case of subacute cutaneous lupus erythematosus associated with Hodgkin's disease. Although our case doesnot fulfill the criteria of paraneoplastic process, a relationship between the two disorders might be suggested by their simultaneous occurrence and in view of the cases of disseminated lupus

J. Castanet; B. Taillan; J. P. Lacour; G. Garnier; C. Perrin; J. P. Ortonne



The association of non-Hodgkin's lymphoma with glomerulonephritis  

Microsoft Academic Search

Paraneoplastic glomerulonephritis is an infrequent complication in the course of non-Hodgkin's lymphoma (21 cases to date). We report a modality not previously described: mesangioproliferative glomerulonephritis and mixed lymphocytic lymphoma, and review the literature on the subject. The onset of the two processes was simultaneous. Antitumour treatment induced simultaneous remission of the lymphoma and glomerulonephritis.

J. A. Girón González; M. Yebra Bango; F. Merino Morales; J. L. Menéndez Caro; F. J. Diego Marín; A. Durántez Martínez



Paraneoplastic syndrome in the course of Hodgkin disease. Case report  

Microsoft Academic Search

A woman with Hodgkin disease presented a neoplastic syndrome of unusual magnitude affecting both the CNS and PNS. The severity of the clinical pattern contrasted strongly with the paucity of neuropathological findings. The report is followed by a brief discussion of the etiological and clinical problems of paraneoplastic syndromes affecting the nervous system.

F. Maggioni; F. Zanchin; F. Vecchio; R. Giordano; L. De Zanche



Pulmonary asbestosis associated to pleural non-Hodgkin lymphoma.  


We describe herein a case report of a patient affected by pulmonary asbestosis who developed a non-Hodgkin lymphoma originating in the pleura. The case is unusual for the uncommon site and because the chronic antigenic stimulation by asbestos bodies may have locally promoted an immunologic derangement. PMID:10228504

Parisio, E; Bianchi, C; Rovej, R; Sparacio, F; Ferrari, A; Scanni, A



Thresholds and Plateaus in the Hodgkin-Huxley Nerve Equations  

Microsoft Academic Search

ABS TR ncT Phase space methods and an analog computer are used to analyze the Hodgkin-Huxley non-linear differential equations for the squid giant axon membrane. V is the membrane potential, m the Na + activation, h the Na + inactivation, and n the K + activation. V and m change rapidly, relative to h and n. The (11, m) phase




Phase dynamics for weakly coupled Hodgkin-Huxley neurons  

Microsoft Academic Search

Hodgkin-Huxley model neurons coupled by weak excitatory interactions are studied by a phase reduction technique. All the information about the coupling between the neurons and their synchronization is then contained in an effective interaction between their phases. One shows analytically that an excitatory coupling can result in an effective inhibition between the neurons reducing their firing rates. Systems of two

D. Hansel; G. Mato; C. Meunier



Non-Hodgkin's Lymphomas in U.S. Navy Personnel.  

National Technical Information Service (NTIS)

Incidence of non-Hodgkin's lymphomas was examined in a prospective study of all white U.S. Navy enlisted men during 1974-83 to test for existence of any short-term risk possibly related to occupation. A total of 103 cases were detected during active servi...

F. C. Garland E. D. Gorham C. F. Garland J. A. Ferns



Presternal soft tissue calcifications following mediastinal radiotherapy for Hodgkin's disease  

SciTech Connect

A patient is described in whom dense calcifications developed in the presternal soft tissues of the chest four years after mediastinal radiotherapy. This is believed to represent dystrophic calcification in previously normal but incidentally radiated tissues following standard dose radiotherapy to the mediastinum for stage IIA Hodgkin's disease.

Vainright, J.R.; Diaconis, J.N.; Haney, P.J.



Primary gastric non-Hodgkin's lymphoma stage IE and IIE  

Microsoft Academic Search

The aim of this study was to evaluate retrospectively the different treatment approaches and outcome of patients with stage IE and IIE gastric non-Hodgkin's lymphoma in a cancer registry. Between 1982 and 1992, the Comprehensive Cancer Centre South (CCCS), Eastern Section, The Netherlands, registered, in a population of 1 million people, a total of 81 cases of gastric lymphoma stage

M. L. M. Lybeert; W. De Neve; L. W. Vrints; V. Coen; J. W. W. Coebergh



Bifurcation control of the Hodgkin–Huxley equations  

Microsoft Academic Search

The Hodgkin–Huxley equations (HH) are parameterized by a number of parameters and show a variety of qualitatively different behaviors. This paper finds that when the externally applied current Iext varies the bifurcation would occur in the HH equations. The HH model’s Hopf bifurcation is controlled by permanent or interval Washout filters (WF), which can transform the subcritical bifurcations into supercritical

Jiang Wang; Liangquan Chen; Xianyang Fei



Granulomatous angiitis of the CNS revealing a Hodgkin lymphoma.  


Apart from the iatrogenic effects of treatment, neurologic complications of Hodgkin lymphoma (HL) can be divided into direct (meningeal or intracranial/spinal localization) and indirect (paraneoplastic/immune complications).(1) Here, we present a patient with granulomatous angiitis of the CNS (GANS) associated with HL that dramatically improved after the treatment of the angiitis by cyclophosphamide, methylprednisolone, and specific chemotherapy. PMID:23269593

Le Guennec, Loïc; Roos-Weil, Damien; Mokhtari, Karima; Chauvet, Dorian; Psimaras, Dimitri; Reiner, Peggy; Demeret, Sophie; Bolgert, Francis; Choquet, Sylvain; Weiss, Nicolas



Lymphomatoid papulosis and Hodgkin's disease: Are they related?  

Microsoft Academic Search

Two different characteristic types of lymphomatoid papulosis (type A and type B) can be histologically distinguished, that represent the ends of a spectrum. In the present report, two patients are described. One patient with both lymphomatoid papulosis type A and type B lesions for more than 25 years developed Hodgkin's disease (nodular sclerosing type) in the para-aortic and para-iliac lymph

R. Willemze; E. Scheffer; W. A. Van Vloten; C. J. L. M. Meijer



Dynamics of unitarization by classicalization  

NASA Astrophysics Data System (ADS)

We study dynamics of the classicalization phenomenon suggested in G. Dvali et al. [1], according to which a class of non-renormalizable theories self-unitarizes at very high-energies via creation of classical configurations (classicalons). We study this phenomenon in an explicit model of derivatively-self-coupled scalar that serves as a prototype for a Nambu-Goldstone-Stückelberg field. We prepare the initial state in form of a collapsing wave-packet of a small occupation number but of very high energy, and observe that the classical configuration indeed develops. Our results confirm the previous estimates, showing that because of self-sourcing the wave-packet forms a classicalon configuration with radius that increases with center of mass energy. Thus, classicalization takes place before the waves get any chance of probing short-distances. The self-sourcing by energy is the crucial point, which makes classicalization phenomenon different from the ordinary dispersion of the wave-packets in other interacting theories. Thanks to this, unlike solitons or other non-perturbative objects, the production of classicalons is not only unsuppressed, but in fact dominates the high-energy scattering. In order to make the difference between classicalizing and non-classicalizing theories clear, we use a language in which the scattering cross section in a generic theory can be universally understood as a geometric cross section set by a classical radius down to which waves can propagate freely, before being scattered. We then show, that in non-classicalizing examples this radius shrinks with increasing energy and becomes microscopic, whereas in classicalizing theories expands and becomes macroscopic. We study analogous scattering in a Galileon system and discover that classicalization also takes place there, although somewhat differently. We thus observe, that classicalization is source-sensitive and that Goldstones pass the first test.

Dvali, Gia; Pirtskhalava, David



The classic: Bone morphogenetic protein.  


This Classic Article is a reprint of the original work by Marshall R. Urist and Basil S. Strates, Bone Morphogenetic Protein. An accompanying biographical sketch of Marshall R. Urist, MD is available at DOI 10.1007/s11999-009-1067-4; a second Classic Article is available at DOI 10.1007/s11999-009-1069-2; and a third Classic Article is available at DOI 10.1007/s11999-009-1070-9. The Classic Article is copyright 1971 by Sage Publications Inc. Journals and is reprinted with permission from Urist MR, Strates BS. Bone morphogenetic protein. J Dent Res. 1971;50:1392-1406. PMID:19727989

Urist, Marshall R; Strates, Basil S



Radiation-induced malignant tumors of bone in patients with Hodgkin's disease  

SciTech Connect

Sixteen cases of radiogenic malignant bone tumors which developed in patients 4 to 31 y after they had received radiation therapy for Hodgkin's disease are compared with 70 similar cases occurring after radiation exposure for other causes. No significant differences in age at irradiation, latent period, histology of tumors or radiographic characteristics were found between the Hodgkin's cases and those of the comparison series. Fourteen of the 16 tumors in Hodgkin's patients, or 87%, were diagnosed in the 15-y period between 1971 and 1985 in contrast to only 34% of the larger non-Hodgkin's series. This difference appears significant and is associated with a doubling of the proportion of Hodgkin's patients who are now living past the minimum latent period for such tumors. The median dose in the Hodgkin's patients, 4000 cGy, is less than the 5100-cGy median in the other patients, and the range and protraction of the total doses are much less. In Hodgkin's patients who have received total nodal irradiation, the volume of osseous tissue which is exposed may reach 25% of the total in the body. This is much greater than in most other treatment plans. Six of the Hodgkin's patients received chemotherapy within a few months of irradiation; only three of 70 non-Hodgkin's patients did so. All of the last factors may have modified the risk of radiation carcinogenesis in the Hodgkin's patients but the data are not yet adequate for quantitation of the effect.

Woodard, H.Q.; Huvos, A.G.; Smith, J.



Chinese Festivals and Customs.  

ERIC Educational Resources Information Center

Traditional festivals and customs of the Chinese people are described in this publication which can be used with secondary level students. In the margins of the text are numbers which indicate slides and cultural objects that relate to the text. The text, however, can be used without the slides and objects. The following festivals are described:…

Green, Sandra Aili


Chinese "Magic" Mirrors.  

ERIC Educational Resources Information Center

Chinese "magic" mirrors are made from bronze with the front side a mirror and the reverse side a molded image. When light is reflected from the mirror,the image on the reverse side appears. Discusses reflections of conventional mirrors, possible explanations for the magic mirror phenomenon, and applications of the phenomenon to semiconductor…

Swinson, Derek B.



Awareness in Chinese Medicine  

Microsoft Academic Search

Awareness - awakening -- is the single most important quality of life to healing and growth in all therapeutics, religion, and philosophy, since the beginning of recorded history. It is central to the changes we must contemplate in terms of healing for both patient and practitioner. Chinese medicine has a great deal to offer through its diagnostic and treatment modalities

Leon Hammer


Chinese New Year Dragons.  

ERIC Educational Resources Information Center

Presents an art project, used in a culturally diverse curriculum, in which second grade students create Chinese New Year dragons. Describes the process of creating the dragons, from the two-week construction of the head to the accordion-folded bodies. (CMK)

Balgemann, Linda



Chinese Drywall Liability  

Microsoft Academic Search

This article presents an overview of the defective Chinese drywall product liability including a timeline starting when complaints were received by the Florida Department of Health in June 2008. The overview of the rapidly evolving product liability also discusses the factors that contributed to drywall demand and the production of synthetic gypsum as well as the common allegations that have

John S. Wyckoff; Robert Martin



Tumor Necrosis Factor ? and Lymphotoxin Production in Hodgkin's Disease  

PubMed Central

It is likely that the characteristic histologic features of Hodgkin's disease reflect cytokine production by the tumor cell population. Tumor necrosis factor ? (TNF-?) and lymphotoxin (tumor necrosis factor beta [TNF-?]) are important inflammatory mediators with wide-ranging effects within the lymphoreticular system. The aim of the present study was to investigate TNF-? and lymphotoxin production in the Hodgkin's disease-derived cell lines L428 and L540. At the product level, both cytokines could be demonstrated by immunostaining with specific monoclonal antibodies. TNF-? could be demonstrated by means of an enzyme-linked immunosorbent assay in culture supernatants from both cell lines as well as in cell lysates of L428 and L540 cells. Cytotoxic activity could be achieved only in L428 supernatants. This cytotoxic activity could not be blocked by the addition of a polyclonal antibody against TNF-?, but was partially inhibited with the monoclonal antibody against lymphotoxin. Synthesis of TNF-? and lymphotoxin in both L428 and L540 was confirmed by demonstrating the intracellular-specific messenger RNA (mRNA) using specific cDNA clones in Northern blot analysis. In situ hybridization studies with the TNF-? cDNA probe gave positive hybridization signals in L428 and in L540. These results demonstrate the transcription, translation, and export of TNF-? and lymphotoxin in cultured Hodgkin's disease-derived cell lines. In addition, results of preliminary experiments are presented in which we demonstrate Reed-Sternberg cells positive for TNF-? protein and mRNA in different Hodgkin's disease tissue biopsies, indicating that, at least for TNF-?, our cell line data are relevant to the neoplastic population present in Hodgkin's disease tissue. ImagesFigure 1Figure 2Figure 3Figure 4

Kretschmer, Claudia; Jones, David B.; Morrison, Kendall; Schluter, Carsten; Feist, Werner; Ulmer, Artur J.; Arnoldi, Jorg; Matthes, Jesco; Diamantstein, Tibor; Flad, Hans-D.; Gerdes, Johannes



Association between simian virus 40 and non-Hodgkin lymphoma  

NASA Technical Reports Server (NTRS)

BACKGROUND: Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma. METHODS: We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses. FINDINGS: Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas. INTERPRETATION: SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

Vilchez, Regis A.; Madden, Charles R.; Kozinetz, Claudia A.; Halvorson, Steven J.; White, Zoe S.; Jorgensen, Jeffrey L.; Finch, Chris J.; Butel, Janet S.



Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenström Macroglobulinemia



Progressive disease following autologous transplantation in patients with chemosensitive relapsed or primary refractory Hodgkin's disease or aggressive non-Hodgkin's lymphoma  

Microsoft Academic Search

To determine the outcome of patients with chemosensitive relapsed or primary refractory Hodgkin's disease (HD) or aggressive non-Hodgkin's lymphoma (NHL) whose disease progresses after autologous stem cell transplantation (ASCT), we reviewed the records of 82 patients with HD and 139 patients with NHL transplanted between 1993 and 2000. Disease progression occurred in 25 patients with HD and 66 patients with

T Kewalramani; S D Nimer; A D Zelenetz; S Malhotra; J Qin; J Yahalom; C H Moskowitz



Classic African American Children's Literature  

ERIC Educational Resources Information Center

The purpose of this article is to assert that there are classic African American children's books and to identify a sampling of them. The author presents multiple definitions of the term classic based on the responses of children's literature experts and relevant scholarship. Next, the manner in which data were collected and analyzed in regard to…

McNair, Jonda C.



Dynamical Symmetries in Classical Mechanics  

ERIC Educational Resources Information Center

We show how symmetries of a classical dynamical system can be described in terms of operators that act on the state space for the system. We illustrate our results by considering a number of possible symmetries that a classical dynamical system might have, and for each symmetry we give examples of dynamical systems that do and do not possess that…

Boozer, A. D.



High incidence of Epstein-Barr virus genomes in Hodgkin's disease.  

PubMed Central

Tissue specimens from 198 cases of Hodgkin's disease and 151 non-Hodgkin lymphomas, as well as 34 nonmalignant lymph node biopsies were examined for the presence of Epstein-Barr virus (EBV) DNA by polymerase chain reaction. Epstein-Barr virus-specific DNA sequences were detected in DNA extracts from frozen and/or paraffin-embedded tissues of 58% of Hodgkin's disease cases. High and low grade non-Hodgkin lymphomas as well as chronic lymphocytic leukemia biopsies contained EBV DNA in 26%, 14%, and 7% of the cases, respectively. Ten percent of the control lymph nodes with normal histology were EBV positive. In Hodgkin's disease biopsies, subsequent in situ hybridization revealed an exclusive localization of the viral DNA in the tumor cells. These findings suggest an involvement of EBV in the pathogenesis of Hodgkin's disease in a substantial proportion of cases. Images Figure 1 Figure 2

Herbst, H.; Niedobitek, G.; Kneba, M.; Hummel, M.; Finn, T.; Anagnostopoulos, I.; Bergholz, M.; Krieger, G.; Stein, H.



Effects of radiation therapy for Hodgkin's disease in a child with ataxia telangiectasia: a clinical, biological and pathologic study  

SciTech Connect

Stage I lymphocyte-predominant Hodgkin's disease was diagnosed in a 44-month-old girl. Although immune deficiency was suspected and IgA deficiency demonstrated, the diagnosis of an ataxia-telangiectasia (AT)-like syndrome was not confirmed until eight weeks later when results of studies on the radiosensitivity of cultured skin fibroblasts were available. The child had none of the usual physical stigmata of AT. Severe acute radiation damage followed the treatment of this child with standard doses of radiation therapy. Clinical, pathologic, and radiobiologic correlations are drawn. The diagnosis of a malignant lymphoma disorder in children under the age of five should alert clinicians to the possibility of immune deficiency and, even in the absence of classical physical signs, to AT in particular. Suggestions for the management of future similar cases are put forward.

Pritchard, J.; Sandland, M.R.; Breatnach, F.B.; Pincott, J.R.; Cox, R.; Husband, P.



Recent Advances in the Pathobiology of Hodgkin's Lymphoma: Potential Impact on Diagnostic, Predictive, and Therapeutic Strategies  

PubMed Central

From its first description by Thomas Hodgkin in 1832, Hodgkin's disease, now called Hodgkin's lymphoma, has continued to be a fascinating neoplasm even to this day. In this review, historical aspects, epidemiology, diagnosis, tumor biology, new observations related to host-microenvironment interactions, gene copy number variation, and gene expression profiling in this complex neoplasm are described, with an exploration of chemoresistance mechanisms and potential novel therapies for refractory disease.

Banerjee, Diponkar



Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin's disease  

SciTech Connect

Sideroblastic anemia after treatment for Hodgkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. This was followed in both by the development of myelomonoblastic leukemia. No evidence of recurrent Hodgkin's disease was present in either patient. Our observation suggests that development of sideroblastic anemia in patients previously treated for Hodgkin's disease is probably secondary to the treatment and is a preleukemic event.

Kitahara, M.; Cosgriff, T.M.; Eyre, H.J.



Blood Transfusion and Risk of Non-Hodgkin's Lymphoma in Connecticut Women  

Microsoft Academic Search

The incidence and mortality rates of non-Hodgkin's lymphoma have been increasing worldwide. Allogeneic blood transfusion has been suggested as a risk factor for non-Hodgkin's lymphoma, but the results from epidemiologic studies have been inconsistent. Data from a population-based case-control study of Connecticut women were analyzed to evaluate this relation. A total of 601 histologically confirmed, non-Hodgkin's lymphoma incident cases identified

Yawei Zhang; Theodore R. Holford; Brian Leaderer; Peter Boyle; Shelia Hoar Zahm; Patricia H. Owens; Lindsay M. Morton; Bing Zhang; Kaiyong Zou; Stuart Flynn


Increased serum IgD concentrations in patients with Hodgkin's disease.  

PubMed Central

Serum IgD concentrations have been determined in twenty-one patients with Hodgkin's disease, in eight patients with non-Hodgkin's lymphomas and in twenty-eight normal (control) individuals by both a solidphase radio-immuno-assay and radial-immunodiffusion. Fourteen of the Hodgkin's patients displayed three to forty-five-fold increased serum IgD levels as compared to control individuals, while in the remaining seven patients IgD concentrations were practically normal. Patients with non-Hodgkin's lymphomas had decreased IgD concentrations.

Corte, G; Ferrarini, M; Tonda, P; Bargellesi, A



Chinese Spacesuit Analysis  

NASA Technical Reports Server (NTRS)

In 2008, China became only the 3rd nation to perform an Extravehicular Activity (EVA) from a spacecraft. An overview of the Chinese spacesuit and life support system were assessed from video downlinks during their EVA; from those assessments, spacesuit characteristics were identified. The spacesuits were compared against the Russian Orlan Spacesuit and the U.S. Extravehicular Mobility Unit (EMU). China's plans for future missions also were presented.

Croog, Lewis



Dermatoglyphs of Chinese Children with Down's Syndrome.  

National Technical Information Service (NTIS)

A dermatoglyphic study of a group of 314 Chinese controls and 53 Chinese patients with the clinical and cytogenetic diagnosis of Down's syndrome has been presented, and results compared with other studies of European groups. The Chinese patient group had ...

J. I. Bryant I. Emanuel S. W. Huang R. Kronmal J. Lo



Chinese herb nephropathy  

PubMed Central

In 1994, a 44-year-old woman progressed from normal renal function to advanced renal failure and end-stage renal disease within 8 months. Biopsy revealed extensive interstitial fibrosis with focal lymphocytic infiltration. She received a cadaveric renal transplant in January 1996 and had an uneventful posttransplant course. As a result of a minor motor vehicle accident, the patient had received acupuncture and Chinese herbal medicine for pain relief approximately 5 months before the onset of renal symptoms. After the transplant, analysis of the herbal remedies clearly indicated the presence of aristolochic acid in 2 of the 6 Chinese herbs ingested. Ingestion of aristolochic acid has been linked to a newly defined entity, Chinese herb nephropathy (CHN). This article discusses the history of CHN and its implication in the current case and in other recent similar cases and makes recommendations to avoid future problems caused by unregulated use of herbal medicines. This is the first reported case of CHN in the USA.



BEACOPP: a new regimen for advanced Hodgkin's disease. German Hodgkin's Lymphoma Study Group.  


The BEACOPP chemotherapy regimen for advanced Hodgkin's disease employs a rearranged schedule permitting a shortened three-week cycle. With haematological growth factor support, the dosages of cyclophosphamide, etoposide and adriamycin could be moderately escalated. The 3-armed multicentre HD9 trial (recruitment 1993-1998; 1300 patients randomised) aimed to compare BEACOPP with the standard COPP/ABVD chemotherapy and to detect and measure the gain in efficacy, if any, due to moderate dose escalation of BEACOPP. Eight cycles were given, followed by local irradiation. The most recent interim analysis, with 689 evaluable patients, circa 40% of all expected events and a median observation time of 27 months, showed significant differences in progression rate (P) and in two-year freedom from treatment failure (F) between the treatment arms, with escalated BEACOPP (P = 2%, F = 89%) better than baseline BEACOPP (P = 9%, F = 81%) better than COPP/ABVD (P = 13%, F = 72%). Survival was not significantly different. Acute toxicity was more severe due to dose escalation, but remained manageable. These preliminary results suggest that BEACOPP improves efficacy. Moderate dose escalation is feasible with G-CSF support and appears likely to make a worthwhile improvement in the cure rate. The results must await confirmation (or otherwise) by the final analysis including all randomised patients and sufficiently mature data. PMID:9926240

Diehl, V; Franklin, J; Hasenclever, D; Tesch, H; Pfreundschuh, M; Lathan, B; Paulus, U; Sieber, M; Rüffer, J U; Sextro, M; Engert, A; Wolf, J; Hermann, R; Holmer, L; Stappert-Jahn, U; Winnerlein-Trump, E; Wulf, G; Krause, S; Glunz, A; von Kalle, K; Bischoff, H; Haedicke, C; Dühmke, E; Georgii, A; Loeffler, M



A structural basis for the Hodgkin and Huxley relation  

NASA Astrophysics Data System (ADS)

Neural channel transport was analyzed using a previously reported relation for charged particle transport in two energy-type gradients: the electric field and here a water/strucural deformation energy. Neural channels are lined with ?-helix structures filled with water vapor and sequestered hydrophobic amino acids arranged to present minimum water vapor and water-hydrophobic interface. Cation point charges generate enormous electric fields on sub-nanometer distances. Electrostatic energy reduction is characterized by dielectric water being pulled toward the transporting ion deforming the neural channel. An ion-water-structure coupling energy is induced by changes in channel diameter width. The resultant two energy gradient relation for cation transport: reduces to the Hodgkin-Huxley relation [A. L. Hodgkin and A. F. Huxley, J. Physiol. (London) 116, 449 (1952)], explains channel selectivity and environmental sensitivity, predicts fast non-dispersive transport under a narrow range of conditions, and produces current-voltage characteristics consistent with observation.

Kang, Yeona; Fortmann, C. M.



[Relation of HLA antigens to prognosis in Hodgkin's disease].  


The prognostic value of HLA antigens in Hodgkin's disease was assessed by multivariate regression analyses. A significantly adverse prognostic impact for achieving complete remission by primary treatment and for its persistence was proved in four antigens locus B (B18, B5, B27 and B15). Five-year survival without signs of the disease, i.e. survival without relapse is significantly lower in subjects with antigen B5, as compared with the group of patients where the antigen was not detected (42% vs. 58%, p = 0.05). An independent prognostic impact of the selected HLA antigens was confirmed in models incl. also formerly tested risk factors for the relapse of Hodgkin's disease. PMID:1771812

Prazák, J; Chytrý, P; Hermanská, Z



Study of HLA antigens in patients with Hodgkin's disease.  


This paper studies relations of 21 HLA antigens of the A and B loci to selected characteristics in a group of patients with Hodgkin's disease. The investigated characteristics are age, sex, histological patterns, clinical stage and symptomatology. The considered group consists of 68 patients, 37 males and 31 females aged from 19 to 66 years and from 26 to 63 yr, respectively. A comparison between antigen frequencies for patients and controls (301 unrelated blood donors) is carried out. The results confirm that there is no relation between HLA antigens and Hodgkin's disease. A significant increase of A11 is found for females under 40 yr. Certain HLA antigens show significant correlation neither with the patient age nor with clinical or histological stages. A significant increase of B5 is observed for 16 relapsed patients. For them, significant test characteristics are found in the presence of cross-reacting HLA-B5, B35. PMID:2788584

Prazák, J; Hermanská, Z



Unusual thoracic radiographic findings in children treated for Hodgkin's disease  

SciTech Connect

Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.



Malignant mesothelioma after radiation treatment for Hodgkin lymphoma.  


Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the disease may be associated with radiation exposure. Recently, increased risks for second primary mesothelioma after radiation for lymphoma have been reported. Because these findings are based on small numbers of patients, they need to be confirmed. We examined mesothelioma risk in 2567 5-year survivors of Hodgkin lymphoma. The risk was almost 30-fold increased in Hodgkin lymphoma patients treated with irradiation compared with the general population. Although histology and survival of the mesothelioma cases were comparable with cases from the general population, asbestos exposure and the proportion of males were lower than expected. The evidence for radiotherapy as cause for mesothelioma independent of exposure to asbestos is expanding, and the diagnosis of mesothelioma should be kept in mind whenever related symptoms arise in patients who had previous irradiation. PMID:19234144

De Bruin, Marie L; Burgers, Jacobus A; Baas, Paul; van 't Veer, Mars B; Noordijk, Evert M; Louwman, Marieke W J; Zijlstra, Josée M; van den Berg, Hendrik; Aleman, Berthe M P; van Leeuwen, Flora E



[Secondary neoplasms in two children with Hodgkin's disease].  


In two out of 59 children with Hodgkin's disease treated with MVPP regimen combined with local irradiation and followed up over 10 years the secondary neoplasms were detected, i.e. in 3.4% with persisting remission of the underlying disease. Chondrosarcoma was diagnosed in one patient in the field of irradiation (after 13 years). This patient died. In the second patient two different tumors (squamous epithelioma and fibrosarcoma) developed after 7 and 9 years following irradiation of two different areas. Actually, there are not any symptoms in this female patients (working). To decrease the incidence of these serious complications of Hodgkin's disease treatment regimens introduced by the Polish Pediatric Leukemia Study Group since 1988, the use of alkylating agents in limited, and the dose of local irradiation is decreased. PMID:1845716

Balwierz, W; Armata, J; Moryl-Bujakowska, A; Miezy?ski, W; Depowska, T; Tredowska, D


Thyroid neoplasia following radiation therapy for Hodgkin's lymphoma  

SciTech Connect

The question of thyroid neoplasia following high-dose radiation treatment to the neck and mediastinum for malignant neoplasms such as Hodgkin's lymphoma in children and young adults has been raised recently. Five patients, 19 to 39 years old, were operated on for thyroid neoplasms that developed following cervical and mediastinal radiation therapy for Hodgkin's lymphoma. Three patients had papillary carcinomas and two had follicular adenomas. The latency period between radiation exposure and the diagnosis of thyroid neoplasm ranged from eight to 16 years. This limited series provided strong support for the recommendation that children and young adults who are to receive high-dose radiation therapy to the head, neck, and mediastinum should receive suppressive doses of thyroxine prior to radiation therapy in order to suppress thyrotropin (thyroid-stimulating hormone) and then be maintained on a regimen of suppression permanently.

McHenry, C.; Jarosz, H.; Calandra, D.; McCall, A.; Lawrence, A.M.; Paloyan, E.



Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease  

SciTech Connect

The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.

Jacobson, D.R.; Fleming, B.J.



Development of Graves' disease following radiation therapy in Hodgkin's disease  

SciTech Connect

Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.



Intermittent hypercalcaemia and vitamin D sensitivity in Hodgkin's disease.  

PubMed Central

A patient with Hodgkin's disease spontaneously developed steroid-responsive hypercalcaemia during two consecutive summers. Administration of 3000 U/day of vitamin D, while he was normocalcaemic, caused a sharp increase in serum 1,25(OH)2D3 (from 59 pg/ml to 142 pg/ml) and subsequently hypercalcaemia while serum 25(OH)D3 rose moderately within the normal range (from 2.8 ng/ml to 10 ng/ml). During a spontaneous episode of hypercalcaemia which was accompanied by increased circulating 1,25(OH)2D3 concentrations, administration of hydrocortisone decreased serum 1,25(OH)2D3 rapidly (from 115 pg/ml to 62 pg/ml) and eventually led to normocalcaemia while serum 25(OH)D3 remained unchanged. Thus the disturbances of mineral metabolism found in this patient with Hodgkin's disease are very similar to those previously described in sarcoidosis.

Karmali, R.; Barker, S.; Hewison, M.; Fraher, L.; Katz, D. R.; O'Riordan, J. L.



A case of concomitant Hodgkin's lymphoma with tuberculosis  

PubMed Central

Tuberculosis (TB) presenting with Hodgkin's Lymphoma is a rare and difficult clinical situation for any physician to identify and to manage because of very similar clinical presentation. Herein we report a case of 29 year old woman who presented with enlarged lymph nodes, diagnosed and initiated on therapy for TB, based on the cervical node biopsy that showed granulomatous lymphadenitis suggestive of TB. Despite being on regular isoniazid, rifampicin, pyrazinamide and ethambutol regimen, she did not improve but worsened clinically! After an extensive work up that included endobronchial ultrasound (EBUS) and mediastinoscopy, a diagnosis of Hodgkin's disease of nodular sclerosis type was made. She was treated with chemotherapy and radiotherapy along with her TB therapy. Patient showed significant improvement following therapy.

Reddy, Ramanjula C.; Mathew, Meghena; Parameswaran, Ashok; Narasimhan, R.



[Non Hodgkin's lymphomas: a major breakthrough with immunotherapy].  


Non hodgkin's lymphomas are a group of haematological malignancies in which spectacular progress has been made over the last ten years thanks to immunotherapy. Furthermore, the new WHO classification, based upon tumour immunology, the degree of tumour differentiation and cytogenetic abnormalities, has finally improved identification of each lymphoma and has enabled comparison of homogeneous populations between different clinical studies. The increase in the incidence of non hodgkin's lymphoma is related to the aging of the population and to other factors that are yet to be elucidated--a real challenge for the future. We have tried to offer an overview of the latest therapeutic advances, with a focus on (radio-) immunotherapy and haemopoietic stem cell transplantation. PMID:21688592

Firescu, R; Muylle, K; Roelandts, M; de Wind, A; Moerman, C; Lemort, M; Kentos, A; Meuleman, N; Bron, D



Classical Foundations: Leah Rochel Johnson  

ERIC Educational Resources Information Center

This article discusses the accomplishments of Leah Rochel Johnson, Assistant Professor of Classics and Ancient Mediterranean Studies and History, Pennsylvania State University. It provides insight into her values and beliefs and testimony from those who work most closely with her.

Lum, Lydia



Quantum Proofs for Classical Theorems  

Microsoft Academic Search

Alongside the development of quantum algorithms and quantum complexity theory in recent years, quantum techniques have also proved instrumental in obtaining results in classical (non- quantum) areas. In this paper we survey these results and the quantum toolbox they use.

Andrew Drucker; Ronald De Wolf



New Perspective on Classical Electromagnetism.  

National Technical Information Service (NTIS)

The fallacies associated with the gauge concept in electromagnetism are illustrated. A clearer and more valid formulation of the basics of classical electromagnetism is provided by recognizing a previously overlooked law of induction as well as the physic...

M. Johnson P. Cote



Etiologic heterogeneity among non-Hodgkin lymphoma subtypes  

Microsoft Academic Search

Understanding patterns of etiologic com- monality and heterogeneity for non- Hodgkin lymphomas may illuminate lym- phomagenesis. We present the first systematic comparison of risks by lym- phoma subtype for a broad range of puta- tive risk factors in a population-based case-control study, including diffuse large B-cell (DLBCL; N 416), follicular (N 318), and marginal zone lymphomas (N 106), and chronic

Lindsay M. Morton; Sophia S. Wang; Wendy Cozen; Martha S. Linet; Nilanjan Chatterjee; Scott Davis; Richard K. Severson; Joanne S. Colt; Mohammad A. Vasef; Nathaniel Rothman; Aaron Blair; Leslie Bernstein; Amanda J. Cross; Anneclaire J. De Roos; Eric A. Engels; David W. Hein; Deirdre A. Hill; Linda E. Kelemen; Unhee Lim; Charles F. Lynch; Maryjean Schenk; Sholom Wacholder; Mary H. Ward; Shelia Hoar Zahm; Stephen J. Chanock; James R. Cerhan; Patricia Hartge


Non-Hodgkin lymphoma response evaluation with MRI texture classification  

Microsoft Academic Search

BACKGROUND: To show magnetic resonance imaging (MRI) texture appearance change in non-Hodgkin lymphoma (NHL) during treatment with response controlled by quantitative volume analysis. METHODS: A total of 19 patients having NHL with an evaluable lymphoma lesion were scanned at three imaging timepoints with 1.5T device during clinical treatment evaluation. Texture characteristics of images were analyzed and classified with MaZda application

Lara CV Harrison; Tiina Luukkaala; Hannu Pertovaara; Tuomas O Saarinen; Tomi T Heinonen; Ritva Järvenpää; Seppo Soimakallio; Pirkko-Liisa I Kellokumpu-Lehtinen; Hannu J Eskola; Prasun Dastidar



Analysis of Aurora B kinase in non-Hodgkin lymphoma  

Microsoft Academic Search

This study explored the levels of Aurora B, a key regulator of mitosis, in 71 lymph nodes and tumor specimens excised operatively from individuals with various types of non-Hodgkin lymphoma (NHLs). Immunohistochemical examination found that diffuse large B-cell lymphoma (10\\/21, 48%) and Burkitt lymphoma (BL) (6\\/7, 86%) cells highly (percentage of positive cells, >20%) expressed Aurora B in their nuclei.

Takayuki Ikezoe; Tamotsu Takeuchi; Jing Yang; Yoshihiro Adachi; Chie Nishioka; Mutsuo Furihata; H Phillip Koeffler; Akihito Yokoyama



Autologous stem cell transplantation in follicular non-Hodgkin's lymphoma  

Microsoft Academic Search

The failure of conventional chemotherapy to improve overall survival rates in follicular non-Hodgkin's lymphoma (NHL) has led to the development of alternative treatment regimens. One such regimen is high-dose chemotherapy (HDT) with autologous stem cell transplantation (ASCT). In ASCT stem cells, harvested predominantly from peripheral blood, are used to repopulate the haemopoietic system after high-dose chemotherapy. Comparison of failure-free survival

R Pettengell



Hodgkin's lymphoma initially presenting with polymyalgic symptoms: a case report  

Microsoft Academic Search

The association of polymyalgic symptoms and lymphoma is a rare event whose pathogenesis remains to be clarified. Here, we\\u000a describe a case of a 75-year old man with Hodgkin's lymphoma, who had presented with polymyalgic symptoms suggesting polymyalgia\\u000a rheumatica. An intensive investigation with respect to malignancy was initially negative. Corticosteroid treatment was administered\\u000a first and a dramatic clinical improvement was

Mehmet Sahin; Guchan Alanoglu; Oguzhan Aksu; Sevket Ercan Tunc; N?lgun Kapucuoglu; Mahmut Yener



A sinister itch: prurigo nodularis in Hodgkin lymphoma.  


A 24 year old lady presented with pruritis and lichenified nodular skin lesions for 1 year. She also had clinical features to suggest a superior venacaval syndrome (SVC) with large rubbery cervical lymph nodes. She was subsequently diagnosed to have Hodgkin lymphoma on lymph node biopsy. Skin changes in lymphoma can precede other clinical symptoms by months. High clinical suspicion and thorough systemic examination would help in excluding a sinister problem in patients with chronic dermatosis. PMID:20329432

Seshadri, Pratibha; Rajan, Sudha Jasmine; George, Ige Abraham; George, Renu



Pleural mesothelioma associated with non-Hodgkin's lymphoma.  


Occupational exposure to asbestos has been associated with an increased incidence of lung and gastric cancers, mesotheliomas, and myelolymphoid malignancies. A new observation of a patient with indirect exposure to asbestos who developed mesothelioma and plasmacytoid lymphocytic non-Hodgkin's lymphoma is described. This report and the previously described stimulation of B lymphocytes by asbestos suggests that the association of mesothelioma with lymphoid and plasma cell malignancies is not merely a coincidence. PMID:7878567

Tondini, M; Rocco, G; Travaglini, M; Rossi, G; Buscemi, A; de Fazio, L



Scientometric portrait of nobel laureate Dorothy Crowfoot Hodgkin  

Microsoft Academic Search

Dorothy Crowfoot Hodgkin (1910–1994), the renowned crystallographer and the Nobel prize winner in Chemistry (1964) was responsible\\u000a for developing the X-ray diffraction method of finding the exact structure of large and complicated molecules, such as Penicillin,\\u000a Vitamin B-12, Insulin, etc. Her 180 publications during 1932–1988 were analyzed by domains, authorship pattern, publication\\u000a productivity, scattering of publications and the keywords used

B. S. Kademani; V. L. Kalyane; Suresh Jange



Does radiotherapy still have a place in Hodgkin lymphoma?  

Microsoft Academic Search

Over half a century, radiation therapy (RT) for Hodgkin lymphoma has been transformed from a radical, extensive, high-dose\\u000a therapy (which alone cured most patients) into an essential component of a comprehensive combined-modality program. RT is\\u000a now used in a “mini” version that encompasses only the clinically involved sites following chemotherapy and is administered\\u000a in a markedly reduced dose. This change

Joachim Yahalom



Treatment of Hodgkin lymphoma: the past, present, and future  

Microsoft Academic Search

Significant advances in the biology and treatment of Hodgkin lymphoma (HL) have been accomplished over the past decades. In a landmark study, DeVita and colleagues showed that half of patients with advanced-stage HL experienced long-term disease-free survival following treatment with a four-drug chemotherapy regimen. Subsequent reports and randomized clinical trials conducted over the past 40 years have defined prognostic categories

Martin Hutchings; Volker Diehl; Andrew M Evens



Spleen in Hodgkin disease: diagnostic value of CT  

SciTech Connect

Findings of CT of the spleen were compared with those of histologic examination in 35 patients who had Hodgkin disease. CT provides a simple way to calculate splenic size. This index is also of value in the assessment of the histologic state of the spleen. An accuracy rate of 91%, specificity of 94%, and a sensitivity of 89% in diagnosing splenic localization of lymphoma was found in this study.

Strijk, S.P.; Wagener, D.J.T.; Bogman, M.J.J.T.; de Pauw, B.E.; Wobbes, T.



Tratamiento de la enfermedad de Hodgkin, esquema MOPP\\/ABV  

Microsoft Academic Search

Resumen  El propósito del presente estudio fue determinar la eficacia de un régimen híbrido de 7 fármacos en pacientes con enfermedad\\u000a de Hodgkin (EH) en estadios avanzados y en estadios tempranos IIB con factores pronósticos desfavorables, y evaluar su toxicidad\\u000a aguda y tardía.\\u000a \\u000a Entre enero del 1988 y diciembre del 1998 fueron tratados 126 pacientes, 70 hombres, promedio de edad de

Greta Corrales; Rosa Somoza Núñez; Jean Desenne Labonardier; Aixa Müller; María Alejandra Torres; Elsa Tovar; Nelson Urdaneta Laffe; Alicia Páez; Mercedes León; Carlos de Jongh García; Esther Arbona; Oswaldo Travieso Travieso



Unusual myeloid leukaemia in patient with Hodgkin's disease.  

PubMed Central

An unusual case of leukaemia in a patient with Hodgkin's disease is described. The leukaemic blast cell population was typified by the presence of a substantial proportion of binucleate and multinucleate cells, many of which had the morphological features of Sternberg-Reed cells. The circulating and bone marrow blast cells were shown by immunophenotyping to be of myeloid origin. Images Fig 1 Fig 2

Horton, M A; Barnett, M J; Goff, L; Czepulkowski, B; Amess, J A; Stansfeld, A G; Lister, T A



Non-Hodgkin's lymphomas and occupation in Sweden  

Microsoft Academic Search

Objectives: To investigate whether there is a risk excess of non-Hodgkin's lymphoma among Swedish workers associated with particular\\u000a occupations. Methods: The base population was made up of Swedish men (1,779,646) and women (1,101,669) who were gainfully employed at the time\\u000a of the 1970 census, had also been present in the 1960 census and were still alive and older than 24?years

María Isabel Cano; Marina Pollán



Second malignancies after Hodgkin's disease: the Munich experience  

Microsoft Academic Search

The occurrence of second malignancies (SM) is an important late event following the treatment of Hodgkin's disease (HD).\\u000a We sought to determine the incidence, the risk factors, and the prognosis of SM in our population of patients with HD. A total\\u000a of 1120 patients diagnosed with HD were registered at six participating institutions in Munich (calendar period 1974–1994).\\u000a The mean

R. Munker; S. Grützner; E. Hiller; Ü. Aydemir; W. Enne; H. Dietzfelbinger; M. Busch; R. Haas; B. Emmerich; M. Schmidt; E. Dühmke; D. Hölzel; W. Wilmanns



Classical theory of radiating strings  

NASA Technical Reports Server (NTRS)

The divergent part of the self force of a radiating string coupled to gravity, an antisymmetric tensor and a dilaton in four dimensions are calculated to first order in classical perturbation theory. While this divergence can be absorbed into a renormalization of the string tension, demanding that both it and the divergence in the energy momentum tensor vanish forces the string to have the couplings of compactified N = 1 D = 10 supergravity. In effect, supersymmetry cures the classical infinities.

Copeland, Edmund J.; Haws, D.; Hindmarsh, M.



Classical and Quantum Mechanical Waves  

NSDL National Science Digital Library

This web site consists of lecture notes in classical and quantum mechanical waves. The notes include the basics of classical waves including connections to mechanical oscillators, wave packets, and acoustic and electromagnetic waves. The final section outlines the key concepts of the quantum mechanical wave equation including probability and current, free and bound states, time dependent perturbation theory, and radiation. Visual Python and Maple animations are included for download.

Riley, Lewis



Role of the gallium scan in Hodgkin's disease  

SciTech Connect

The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patients studied. There were no significant differences in overall results between newer and older gallium scanning techniques. For untreated patients, the overall sensitivity was only 64%, but the overall specificity was 98%. For untreated patients and for patients with relapsing disease, the presence of gallium concentration in a specific site was highly predictive of active Hodgkin's disease at that site. However, for routine follow-up of treated patients, 95% of unsuspected relapses were missed by the scan, indicating the limited usefulness of negative scan results in this setting. For patients with residual abnormalities after therapy, demonstrated by other radiographic means, increased uptake of gallium in abdominal or peripheral lymph nodes also indicated active disease, although lack of uptake was reliable only in the mediastinum. Based on these results, it appears that the higher doses used in this study have not substantially improved the role of gallium scanning in this disease. Although it is potentially useful in providing confirmatory data at diagnosis or in patients with new or residual objective abnormalities after treatment, routine use of gallium scanning in Hodgkin's disease is not recommended.

Hagemeister, F.B.; Fesus, S.M.; Lamki, L.M.; Haynie, T.P. (Univ. of Texas, M.D. Anderson Cancer Center, Houston (USA))



Chinese Treasure Chest: An Integrated Exploratory Chinese Language & Culture Program.  

ERIC Educational Resources Information Center

This publication describes the Chinese Treasure Chest project, an exploratory Chinese language and culture program developed by two elementary school teachers in the Aleutians East Borough (Alaska) School District. The project centers on the use of a large box of materials and a program plan designed to introduce elementary students in…

Jensen, Inge-Lise; Verg-in, Yen-ti


Hodgkin Disease: Hodgkin and Reed-Sternberg Cells Picked from Histological Sections Show Clonal Immunoglobulin Gene Rearrangements and Appear to be Derived from B Cells at Various Stages of Development  

Microsoft Academic Search

Hodgkin disease (HD) is characterized by a small number of putative malignant cells [Hodgkin and Reed-Sternberg (HRS) cells] among a background of lymphocytes and histiocytes. The lineage of HRS cells is still elusive and a clonal origin of these rare cells has not formally been demonstrated. We isolated HRS cells by micromanipulation from histological sections of three cases of Hodgkin

Ralf Kuppers; Klaus Rajewsky; Min Zhao; Gunther Simons; Ralf Laumann; Robert Fischer; Martin-Leo Hansmann



Disparities in survival after Hodgkin lymphoma: a population-based study.  


Survival after Hodgkin lymphoma (HL) is generally favorable, but may vary by patient demographic characteristics. The authors examined HL survival according to race/ethnicity and neighborhood socioeconomic status (SES), determined from residential census-block group at diagnosis. For 12,492 classical HL patients ? 15 years diagnosed in California during 1988-2006 and followed through 2007, we determined risk of overall and HL-specific death using Cox proportional hazards regression; analyses were stratified by age and Ann Arbor stage. Irrespective of disease stage, patients with lower neighborhood SES had worse overall and HL-specific survival than patients with higher SES. Patients with the lowest quintile of neighborhood SES had a 64% (patients aged 15-44 years) and 36% (? 45 years) increased risk of HL-death compared to patients with the highest quintile of SES; SES results were similar for overall survival. Even after adjustment for neighborhood SES, blacks and Hispanics had increased risks of HL-death 74% and 43% (15-44 years) and 40% and 17% (? 45 years), respectively, higher than white patients. The racial/ethnic differences in survival were evident for all stages of disease. These data provide evidence for substantial, and probably remediable, racial/ethnic and neighborhood SES disparities in HL outcomes. PMID:19557531

Keegan, Theresa H M; Clarke, Christina A; Chang, Ellen T; Shema, Sarah J; Glaser, Sally L



[Primary non-Hodgkin lymphoma of the liver: case report and review of the literature].  


Purpose was to describe the clinical, radiological and therapeutic features in primary liver lymphoma. We report the case of a 54-year-old patient, who is followed since the age of 20 years for neutropenia associated with mediastinal adenopathy. Systematical ultrasound find a mass of the left liver confirmed by Computed tomography (CT). Histological examination of laparoscopic liver biopsy specimens confirmed diffuse large-cell non-Hodgkin's lymphoma. The disease was confined to the liver without any evidence of extrahepatic involvement. The serology of Epstein Barr virus was highly positive. PET-scan show increased FDG uptake at the site of hepatic lesion and the mediastin. The patient received chemotherapy followed by radiation therapy of the left liver at the dose of 31 Gy. The patient was alive and free of disease 20 months after the diagnosis of primary liver lymphoma. The primary hepatic lymphoma is a rare malignancy, which classically affects 50-year-old patients with a male preponderance. The incidence is increased in immunosuppressed patients and some authors have suggested an association with hepatitis B or C infection, and with the Epstein Barr virus. The imaging studies including ultrasound, CT, magnetic resonance imaging (MRI) and now PET-scan help to establish the diagnosis and to the following. Treatment options are surgery, radiation, chemotherapy, or a combination. PMID:17137818

Nasr Ben Ammar, C; Chaari, N; Kochbati, L; Besbes, M; Maalej, M



Quality control of involved-field radiotherapy in patients with advanced Hodgkin’s lymphoma (EORTC 20884)  

Microsoft Academic Search

PURPOSE: To evaluate the impact of the quality of involved-field radiotherapy (IFRT) on clinical outcome in patients with advanced Hodgkin's lymphoma (HL) in complete remission (CR) after six to eight cycles of mechlorethamine, vincristine, procarbazine, prednisone-doxorubicin, bleomycin, and vinblastine (MOPP-ABV) chemotherapy. METHODS AND MATERIALS: A retrospective review of clinical and radiologic data, radiation charts, simulator films, and megavoltage (MV) photographs

Berthe M. P. Aleman; Théodore Girinsky; Richard W. M. van der Maazen; Simon Strijk; Paul Meijnders; Roberto Bortolus; Manouk J. J. Olofsen-van Acht; Marnix L. M. Lybeert; Yolande Lievens; Houchingue Eghbali; Evert M. Noordijk; Radka Tomši?; Jacobus H. Meerwaldt; Philip M. P. Poortmans; Wilma G. J. M. Smit; Antonella Pinna; Michel Henry-Amar; John M. M. Raemaekers



Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma

Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome



Induction of autotaxin by the Epstein-Barr virus promotes the growth and survival of Hodgkin lymphoma cells  

Microsoft Academic Search

A proportion of patients with Hodgkin lymphoma carry Epstein-Barr virus (EBV), an oncogenic herpesvirus, in their tumor cells. Although it is generally assumed that EBV contributes to the malignant phenotype of Hodgkin lymphoma cells, direct evidence in support of this is lack- ing. Here we show that EBV infection of Hodgkin lymphoma cells results in the induction of autotaxin, a

Karl R. N. Baumforth; Joanne R. Flavell; Gary M. Reynolds; Gillian Davies; Trevor R. Pettit; Wenbin Wei; Susan Morgan; Tanya Stankovic; Yasuhiro Kishi; Hiroyuki Arai; Marketa Nowakova; Guy Pratt; Junken Aoki; Michael J. O. Wakelam; Lawrence S. Young; Paul G. Murray



Hodgkin lymphoma: 2014 update on diagnosis, risk-stratification, and management.  


Disease overview: Hodgkin lymphoma (HL) is an uncommon B-cell lymphoid malignancy affecting 9,200 new patients annually and representing approximately 11.5% of all lymphomas in the United States. Diagnosis: HL is composed of two distinct disease entities; the more commonly diagnosed classical HL and the rare nodular lymphocyte-predominant HL. Nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich HL are subgroups under the designation of classical HL. Risk stratification: An accurate assessment of the stage of disease in patients with HL is critical for the selection of the appropriate therapy. Prognostic models that identify patients at low or high risk for recurrence, as well as the response to therapy as determined by positron emission tomography scan, are used to optimize therapy. Risk-adapted therapy: Initial therapy for HL patients is based on the histology of the disease, the anatomical stage, and the presence of poor prognostic features. Patients with early stage disease are treated with combined modality strategies using abbreviated courses of combination chemotherapy followed by involved-field radiation therapy, while those with advanced stage disease receive a longer course of chemotherapy often without radiation therapy. Management of relapsed/refractory disease: High-dose chemotherapy (HDCT) followed by an autologous stem cell transplant (ASCT) is the standard of care for most patients who relapse following initial therapy. For patients who fail HDCT with ASCT, brentuximab vedotin, palliative chemotherapy, nonmyeloablative allogeneic transplant, or participation in a clinical trial should be considered. Am. J. Hematol. 89:772-779, 2014. © 2014 Wiley Periodicals, Inc. PMID:24953862

Ansell, Stephen M



Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia



Teaching Chinese as Tomorrow's Language  

ERIC Educational Resources Information Center

Relatively few public school students are currently learning the Chinese language, but experts predict the number of K-12 schools offering such instruction will soon soar. With China poised to become the next global economic superpower, policymakers say it is essential that American schools expand their Chinese studies. Here, the author discusses…

Chmelynski, Carol




ERIC Educational Resources Information Center




An Introduction to Chinese Literature.  

ERIC Educational Resources Information Center

This unit will introduce secondary level students to Chinese literature. The first part of the unit discusses poetry which has always been the most highly prized form of Chinese literature. The discussion examines the "Complete Tang Poems," the "Book of Songs" compiled by Confucius, the "Songs of Chu," and the "Li Sao." Students learn about the…

Kane, Tony


Sexual quality of life in Hodgkin Lymphoma: a longitudinal analysis by the German Hodgkin Study Group  

PubMed Central

Background: Health-related quality of life (HRQoL) comprises different domains of physical, mental, and social well-being. In this analysis, we focus on sexual quality of life in Hodgkin Lymphoma (HL) patients. Methods: Four-thousand one-hundred and sixty patients enroled in the HD10–HD12 trials underwent HRQoL assessment. Instruments included the Quality of Life Questionnaire for survivors (QLQ-S), combining the European Organisation for Research and Treatment of Cancer QLQ-C30, Multidimensional fatigue (FA) inventory (MFI-20) and an additional sexual functioning (SX) scale. We describe SX up to 27 months after therapy and analyse relationship to stage, age, gender, FA, social functioning, and therapy. Statistical methods range from descriptive statistics to a classification of SX courses, and a longitudinal structural equations model with full information maximum likelihood estimation of missing data. In the analysis, a score below 50 was used to describe severe sexual dysfunction. Results: Three-thousand two-hundred and eight patients provided data on SX. Patients in advanced stages reported lower SX than patients in early stages both, before and after the treatment. During follow-up, an improvement of SX compared with baseline was detected, except for those ?50 years. Patients in early stages reached normal SX, whereas advanced-stage patients remained below the reference value for healthy controls. Sexual functioning during follow-up was significantly and strongly related to previous SX, other HRQoL measures, age, and stage, and to lesser degree with gender and chemotherapy. Conclusion: Overall, HL patients have a decreased sexual quality of life at baseline, which improves after therapy and normalises in early-stage patients. Importantly, long-term SX is more closely related to patient characteristics and SX at baseline than to the intensity of treatment.

Behringer, K; Muller, H; Gorgen, H; Flechtner, H-H; Brillant, C; Halbsguth, T V; Thielen, I; Eichenauer, D A; Schober, T; Nisters-Backes, H; Fuchs, M; Engert, A; Borchmann, P



Striated pattern on scrotal ultrasonography: A marker for Non-hodgkins lymphoma of testis  

PubMed Central

We present a case of 52 year old man who presented with bilateral painless testicular swelling. On evaluation with high resolution ultrasonography of the scrotum, typical “striated pattern” which is highly suggestive of Non Hodgkins lymphoma of the testis was seen. The patient underwent bilateral inguinal orchidectomy and the histopathological examination confirmed the diagnosis of Non Hodgkins lymphoma.

Bhat, Suresh; Sachin, Joseph; Ramaprasad; Job, Suma



Bortezomib down-modulates the survival factor interferon regulatory factor 4 in Hodgkin lymphoma cell lines and decreases the protective activity of Hodgkin lymphoma-associated fibroblasts.  


Bortezomib is a proteasome inhibitor active in classical Hodgkin lymphoma (cHL) cell lines, but poorly active in the clinic when used as a single agent, suggesting that the microenvironment could protect from drug efficacy. Therefore, we investigated the effects of bortezomib activity in the presence of HL-associated fibroblasts (HL-AFs) and sCD40L. We found that co-cultivation with human HL-AFs or the addition of sCD40L during bortezomib treatment protected cHL cells from apoptosis and cytotoxicity and rescued the down-regulation of the survival factor interferon regulatory factor 4 (IRF4). In contrast, bortezomib treatment before co-cultivation with HL-AFs inhibited in a dose-dependent manner cHL cell adhesion to HL-AFs and completely overcame HL-AF protection against drug activity. Consistently, we found that bortezomib treatment down-regulated the surface expression of CD49d and CD44, which mediate the adhesion of cHL cells to HL-AFs, and of CD54 and CD40, which mediate the adhesion to CD40L+ rosetting T-cells. These preclinical findings suggest that the low in vivo activity of bortezomib as a single agent may be due to a protective influence of the microenvironment. However, inclusion of bortezomib in the cHL drug regimen, by reducing IRF4 expression and interactions with the microenvironment, could increase the efficacy of current chemotherapeutic treatment of relapsed/refractory cHL. PMID:23647062

Celegato, Marta; Borghese, Cinzia; Casagrande, Naike; Carbone, Antonino; Colombatti, Alfonso; Aldinucci, Donatella



Classical approach in atomic physics  

NASA Astrophysics Data System (ADS)

The application of a classical approach to various quantum problems - the secular perturbation approach to quantization of a hydrogen atom in external fields and a helium atom, the adiabatic switching method for calculation of a semiclassical spectrum of a hydrogen atom in crossed electric and magnetic fields, a spontaneous decay of excited states of a hydrogen atom, Gutzwiller's approach to Stark problem, long-lived excited states of a helium atom discovered with the help of Poincaré section, inelastic transitions in slow and fast electron-atom and ion-atom collisions - is reviewed. Further, a classical representation in quantum theory is discussed. In this representation the quantum states are treated as an ensemble of classical states. This approach opens the way to an accurate description of the initial and final states in classical trajectory Monte Carlo (CTMC) method and a purely classical explanation of tunneling phenomenon. The general aspects of the structure of the semiclassical series such as renormgroup symmetry, criterion of accuracy and so on are reviewed as well.

Solov'ev, E. A.



Detection of Hodgkin Transformation in a Case of Chronic Lymphocytic Leukemia by PET/CT  

PubMed Central

Richter’s transformation (RT) represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). CLL/SLL may convert also to Hodgkin’s lymphoma, the so-called Hodgkin’s variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients with RT generally have a poor prognosis, with prompt recognition optimise clinical management. Whole-body PET scan with 18F-FDG can be used for detection of RT of CLL/SLL. We describe the case of 64-year-old woman with CLL/SLL who developed Hodgkin lymphoma detected with PET/CT.

Y?lmaz, Sabire; Ozhan, Meftune; Asa, Sertac; Sager, M. Sait; Biricik, Fatih Selcuk; Halac, Metin; Sonmezoglu, Kerim



From classical to quantum criticality  

NASA Astrophysics Data System (ADS)

We study the crossover from classical to quantum phase transitions at zero temperature within the framework of ?4 theory. The classical transition at zero temperature can be described by the Landau theory, turning into a quantum Ising transition with the addition of quantum fluctuations. We perform a calculation of the transition line in the regime where the quantum fluctuations are weak. The calculation is based on a renormalization group analysis of the crossover between classical and quantum transitions, and is well controlled even for space-time dimensionality D below 4. In particular, for D =2 we obtain an analytic expression for the transition line which is valid for a wide range of parameters, as confirmed by numerical calculations based on the density matrix renormalization group. This behavior could be tested by measuring the phase diagram of the linear-zigzag instability in systems of trapped ions or repulsively interacting dipoles.

Podolsky, Daniel; Shimshoni, Efrat; Silvi, Pietro; Montangero, Simone; Calarco, Tommaso; Morigi, Giovanna; Fishman, Shmuel



Optimum Onager: The Classical Mechanics of a Classical Siege Engine  

ERIC Educational Resources Information Center

The onager is a throwing weapon of classical antiquity, familiar to both the ancient Greeks and Romans. Here we analyze the dynamics of onager operation and derive the optimum angle for launching a projectile to its maximum range. There is plenty of scope for further considerations about increasing onager range, and so by thinking about how this…

Denny, Mark



Chinese Children's Attitudes Toward Mental Retardation  

Microsoft Academic Search

The present study aimed to: (1) examine Chinese children's attitudes toward mental retardation, (2) investigate cross-cultural similarities or differences in these attitudes, and (3) extend the use of Western-attitude questionnaires to Chinese samples. The present study included 489 Chinese children (265 boys and 224 girls), aged from 4 to 15 years. Results showed that Chinese children demonstrated favorable attitudes toward

Catherine So-kum Tang; Cindy Davis; Anize Wu; Christopher Oliver



What Should American-Born Chinese Children Learn?  

ERIC Educational Resources Information Center

This paper discusses the teaching of Chinese to both students with Chinese background and students with non-Chinese background. It is suggested that students with a Chinese background be separated from those without a Chinese background in order not to discourage the latter group from studying Chinese. Chinese background students should be taught…

Chang, Shirley


Classical hadrodynamics for extended nucleons  

SciTech Connect

We discuss a new approach to relativistic nucleus-nucleus collisions based on classical hadrodynamics for extended nucleons, corresponding to nucleons of finite size interacting with massive meson fields. This theory provides a natural covariant microscopic approach to relativistic nucleus-nucleus collisions that includes automatically spacetime nonlocality and retardation, nonequilibrium phenomena, interactions among all nucleons, and particle production. Inclusion of the finite nucleon size cures the difficulties with preacceleration and runaway solutions that have plagued the classical theory of self-interacting point particles.

Bush, B.W.; Nix, J.R.



Epstein–Barr virus expression in Hodgkin’s disease in relation to patient characteristics, serum factors and blood lymphocyte function  

Microsoft Academic Search

Epstein–Barr virus (EBV) expression was investigated by immunohistochemistry (latent membrane protein 1 [LMP-1]) and in situ hybridization (EBV encoded RNA [EBER]) in biopsies from 95 patients with untreated Hodgkin’s disease (HD). Tumour EBV status was related to EBV antibody titres, spontaneous and concanavallin A induced blood lymphocyte DNA synthesis, serum levels of soluble (s) CD4, sCD8, sCD25, sCD30, sCD54, ?2-microglobulin,

U Axdorph; A Porwit-MacDonald; J Sjöberg; G Grimfors; M Ekman; W Wang; P Biberfeld; M Björkholm



Analysis of in-field control and late toxicity for adults with early-stage hodgkin’s disease treated with chemotherapy followed by radiotherapy  

Microsoft Academic Search

Purpose: We analyzed in-field (IF) control in adults with early-stage Hodgkin’s disease who received chemotherapy followed by radiotherapy (RT) in terms of the (1) chemotherapeutic regimen used and number of cycles delivered, (2) response to chemotherapy, and (3) initial tumor size. Cardiac toxicity and second malignancies, particularly the incidence of solid tumors in terms of the RT field size treated,

Gregory M Chronowski; Richard B Wilder; Susan L Tucker; Chul S Ha; Anas Younes; Luis Fayad; Maria A Rodriguez; Fredrick B Hagemeister; Ibrahim Barista; Fernando Cabanillas; James D Cox



795. The Use of Autologous LMP2Specific Cytotoxic T Lymphocytes for the Treatment of Relapsed EBV +ve Hodgkin Disease and Non-Hodgkin Lymphoma  

Microsoft Academic Search

EBV-associated Hodgkin's Disease (HD) and some non-Hodgkins lymphoma (NHL) show type II latency expressing the subdominant EBV antigens EBNA1, LMP1 and LMP2, which may serve as targets for immunotherapy approaches. In previous studies, we used polyclonal EBV-specific CTL in patients with relapsed EBV +ve HD and saw 2 complete and 1 partial response in 11 patients. Analyses of EBV-CTL lines

Catherine M. Bollard; Stephen Gottschalk; Elizabeth Buza; Helen Huls; Vicky Gresik; George Carrum; Malcolm K. Brenner; Cliona M. Rooney; Helen E. Heslop



The role of routine imaging procedures in the detection of relapse of patients with Hodgkin lymphoma and aggressive non-Hodgkin lymphoma  

Microsoft Academic Search

Despite improved initial therapies, a subgroup of patients with aggressive non-Hodgkin (A-NHL) and Hodgkin lymphomas (HL)\\u000a will relapse after first remission. The optimal follow-up strategy for the detection of relapse has not been clarified and\\u000a periodic imaging is not recommended in most written guidelines. We identified 125 patients with HL and A-NHL diagnosed between\\u000a January 1993 and September 2008 who

Neta Goldschmidt; Omer; Martine Klein; Bella Savitsky; Ora Paltiel



Rituximab in relapsed lymphocyte-predominant Hodgkin lymphoma: long-term results of a phase 2 trial by the German Hodgkin Lymphoma Study Group (GHSG)  

Microsoft Academic Search

Because nodular lymphocyte-predomi- nant Hodgkin lymphoma (NLPHL) ex- press CD20, rituximab may be used as a nonmutagenic treatment option to avoid late toxicities in this rather indolent en- tity. Between 1999 and 2004, the German Hodgkin Study Group (GHSG) investi- gated the activity of rituximab (375 mg\\/m2 in 4 doses) in a phase 2 trial in 21 relapsed or refractory

Holger Schulz; Ute Rehwald; Franck Morschhauser; Thomas Elter; Christoph Driessen; Thomas Rudiger; Peter Borchmann; Roland Schnell; Volker Diehl; Andreas Engert; Marcel Reiser



Breast cancer after mantle irradiation for Hodgkin’s disease: correlation of clinical, pathologic, and molecular features including loss of heterozygosity at BRCA1 and BRCA2  

Microsoft Academic Search

Purpose: Hodgkin’s disease patients who receive mantle irradiation have an age-dependent increased risk of developing breast cancer. To determine if genetic factors predispose these patients to develop breast cancer, we evaluated breast cancer specimens for loss of heterozygosity (LOH) at regions where BRCA1 and BRCA2, two breast cancer tumor suppressor genes, are located. We also evaluated whether breast cancers in

David K Gaffney; John Hemmersmeier; Joseph Holden; Jay Marshall; Lynn M Smith; Vilija Avizonis; Thao Tran; Susan L Neuhausen



Comparison between hybrid MOPPABV and ABVD chemotherapy protocols for Hodgkin’s lymphoma in public hospitals of the largest South American city—a retrospective 14-year study  

Microsoft Academic Search

The behavior of Hodgkin’s lymphoma (HL) is different in developing countries, perhaps due to differences in epidemiology and\\u000a population access to health care. We performed a retrospective study comparing the efficacy of mechlorethamine, vincristine,\\u000a procarbazine, prednisone, doxorubicin, bleomycin, and vinblastine (MOPPABV) versus adriamycin, bleomycin, vinblastine, and\\u000a dacarbazine (ABVD) chemotherapy protocols as first-line therapy for HL in a Brazilian population. A

E. M. Souza; O. C. G. Baiocchi; M. A. Zanichelli; A. C. Alves; J. S. R. Oliveira



High-dose therapy and autologous stem cell rescue for patients with Hodgkin’s disease in first relapse after chemotherapy: results from the EBMT  

Microsoft Academic Search

The purpose of this study was to investigate the results of high-dose therapy and autologous stem cell transplantation in adult patients with Hodgkin’s disease in first relapse after chemotherapy, to determine the overall and progression-free survival, identify prognostic factors for outcome, and to define the role of conventional dose salvage therapy given prior to the high dose regimen. A retrospective

JW Sweetenham; G Taghipour; D Milligan; AK Blystad; D Caballero; A Fassas; AH Goldstone



Paternal origins of Chinese cattle.  


To determine the genetic diversity and paternal origin of Chinese cattle, 302 males from 16 Chinese native cattle breeds as well as 30 Holstein males and four Burma males as controls were analysed using four Y-SNPs and two Y-STRs. In Chinese bulls, the taurine Y1 and Y2 haplogroups and indicine Y3 haplogroup were detected in seven, 172 and 123 individuals respectively, and these frequencies varied among the Chinese cattle breeds examined. Y2 dominates in northern China (91.4%), and Y3 dominates in southern China (90.8%). Central China is an admixture zone, although Y2 predominates overall (72.0%). The geographical distributions of the Y2 and Y3 haplogroup frequencies revealed a pattern of male indicine introgression from south to north China. The three Y haplogroups were further classified into one Y1 haplotype, five Y2 haplotypes and one Y3 haplotype in Chinese native bulls. Due to the interplay between taurine and indicine types, Chinese cattle represent an extensive reservoir of genetic diversity. The Y haplotype distribution of Chinese cattle exhibited a clear geographical structure, which is consistent with mtDNA, historical and geographical information. PMID:23347145

Li, R; Zhang, X M; Campana, M G; Huang, J P; Chang, Z H; Qi, X B; Shi, H; Su, B; Zhang, R F; Lan, X Y; Chen, H; Lei, C Z



Polymorphisms in methylenetetrahydrofolate reductase gene and risk of non-Hodgkin lymphoma in a multi-ethnic population.  


An imbalance in folate metabolism can adversely affect DNA synthesis and methylation systems which can lead to susceptibility to non-Hodgkin lymphoma (NHL). Whether single nucleotide polymorphisms (SNPs) and their haplotypes in the methylenetetrahydrofolate reductase (MTHFR) are associated with NHL, remain inconclusive. We investigated the association between MTHFR C677T and A1298C SNPs and NHL risk in a population which is made up of Malay, Chinese and Indian ethnic subgroups. A total of 372 NHL patients and 722 controls were genotyped using the Sequenom MassARRAY platform. Our results of the pooled subjects failed to demonstrate significant association between the MTHFR C677T and A1298C SNPs with NHL and its subtypes. The results were in agreement with the previous meta-analyses. In the Indian ethnic subgroup however, single locus analysis of MTHFR A1298C appears to confer risk to NHL (Odds ratio (OR) 1.91, 95% confidence interval (95% CI) 1.22-3.00, P=0.006). The risk is almost doubled in homozygous carrier of MTHFR 1298CC (OR 4.03, 95% CI 1.56-10.43, P=0.004). Haplotype analysis revealed higher frequency of CC in the Indian NHL patients compared with controls (OR 1.86, 95% CI 1.18-2.93, P=0.007). There is lack of evidence to suggest an association between MTHFR C677T and A1298C with the risk of NHL in the Malays and Chinese. In the Indians however, the MTHFR A1298C confers risk to NHL. This study suggests ethnicity modifies the relationship between polymorphisms in the folate-metabolizing gene and NHL. PMID:24646728

Suthandiram, Sujatha; Gan, Gin Gin; Zain, Shamsul Mohd; Haerian, Batoul Sadat; Bee, Ping Chong; Lian, Lay Hoong; Chang, Kian Meng; Ong, Tee Chuan; Mohamed, Zahurin



Probability in Classical Statistical Mechanics  

Microsoft Academic Search

How can probabilistic statements be understood in the deterministic theory of classical statistical mechanics? Are they epistemic, i.e. do they reflect our ignorance of the exact state of a system, or objective, in the sense that they represent relative frequencies of some sort? Are there perhaps other options? These questions are central in Guttmann's book. The core of the book

Janneke van Lith


Classical analogues of quantum paradoxes  

Microsoft Academic Search

In this note we discuss a few simple classical (as opposed to quantum) prediction problems. The thrust of this work is to examine the predictive role of probability theory and we shall see that some situations are not re- ally paradoxical. In particular we want to separate the role of probability as a predictive tool from one of the basic

Henryk Gzyl



Instantaneous fields in classical electrodynamics  

Microsoft Academic Search

In this paper we express the retarded fields of Maxwell's theory in terms of the instantaneous fields of a Galilei-invariant electromagnetic and we find the vector function L whose spatial and temporal derivatives transform the Euclidean fields into the retarded ones. We conclude that the instantaneous fields can formally be introduced as unphysical objects into classical electrodynamics which can be

Jose A. Heras



Classical simulation of entangled states  

NASA Astrophysics Data System (ADS)

Characterization of nonclassicality or quantumness of a state is fundamental to foundations of quantum mechanics and quantum information. At the heart of the problem is the question whether there exist classical systems—howsoever complicated—that can mimic a given quantum state. Whilst this has been traditionally addressed through the violation of Bell inequality or nonseparability, we show that it is possible to go beyond them, by introducing the concept of classical simulation. Focusing on the two-qubit case, we show that, while for pure states, classical simulability is equivalent to existence of a local hidden variable (LHV) model, the conditions for simulability can be weaker for mixed states, demanding what we call only a generalized LHV description. Consequently, quantum states which defy a classical simulation—which we call exceptional—may require conditions which are more stringent than violation of Bell inequalities. We illustrate these features with a number of representative examples and discuss the underlying reasons, by employing fairly simple arguments.

Bharath, H. M.; Ravishankar, V.



Finger Microcirculation in Classical Migraine  

Microsoft Academic Search

We assessed microcirculation in nailfold capillaries of 22 patients with classical migraine and 22 normal subjects matched for age and sex using video-microscopy. Blood flow measurements were performed under standardized room temperature, after a 3-min warm water bath and after local cooling. Under standardized conditions, skin temperature at the fingertip was significantly lower in patients with migraine. Morphological differences, however,

P. Gasser; O. Meienberg



Measurement-based classical computation.  


Measurement-based quantum computation (MBQC) is a model of quantum computation, in which computation proceeds via adaptive single qubit measurements on a multiqubit quantum state. It is computationally equivalent to the circuit model. Unlike the circuit model, however, its classical analog is little studied. Here we present a classical analog of MBQC whose computational complexity presents a rich structure. To do so, we identify uniform families of quantum computations [refining the circuits introduced by Bremner Proc. R. Soc. A 467, 459 (2010)] whose output is likely hard to exactly simulate (sample) classically. We demonstrate that these circuit families can be efficiently implemented in the MBQC model without adaptive measurement and, thus, can be achieved in a classical analog of MBQC whose resource state is a probability distribution which has been created quantum mechanically. Such states (by definition) violate no Bell inequality, but, if widely held beliefs about computational complexity are true, they, nevertheless, exhibit nonclassicality when used as a computational resource—an imprint of their quantum origin. PMID:24765935

Hoban, Matty J; Wallman, Joel J; Anwar, Hussain; Usher, Naïri; Raussendorf, Robert; Browne, Dan E



Classical energy confinement in Alcator  

Microsoft Academic Search

Nearly classical behaviour, from the viewpoint of energy confinement, is observed in the Alcator tokamak. A study of the energy balance of the central core of the plasma has been carried out in the regime 1014 cm-3 <=n¯e <= 6 × 1014 cm-3, 130 kA <= IP <= 160 kA and BT = 6 T. At the higheet densities the

A. Gondhalekar; D. Overskei; R. R. Parker



Quantization of Inequivalent Classical Hamiltonians.  

ERIC Educational Resources Information Center

Shows how the quantization of a Hamiltonian which is not canonically related to the energy is ambiguous and thereby results in conflicting physical interpretations. Concludes that only the Hamiltonian corresponding to the total energy of a classical system or one canonically related to it is suitable for consistent quantization. (GA)

Edwards, Ian K.



Teaching Cognitive Science as Classics  

Microsoft Academic Search

Cognitive science is usually taught as a postgraduate course, or as a relevant group of under- graduate units brought together as a major course of study in cognitive science. This paper argues that more basic units can be taught somewhat as classics used to be, aiming to incor- porate quite basic but essential learning into undergraduate degrees, and should even

Neville Holmes


Measurement-Based Classical Computation  

NASA Astrophysics Data System (ADS)

Measurement-based quantum computation (MBQC) is a model of quantum computation, in which computation proceeds via adaptive single qubit measurements on a multiqubit quantum state. It is computationally equivalent to the circuit model. Unlike the circuit model, however, its classical analog is little studied. Here we present a classical analog of MBQC whose computational complexity presents a rich structure. To do so, we identify uniform families of quantum computations [refining the circuits introduced by Bremner et al. Proc. R. Soc. A 467, 459 (2010)] whose output is likely hard to exactly simulate (sample) classically. We demonstrate that these circuit families can be efficiently implemented in the MBQC model without adaptive measurement and, thus, can be achieved in a classical analog of MBQC whose resource state is a probability distribution which has been created quantum mechanically. Such states (by definition) violate no Bell inequality, but, if widely held beliefs about computational complexity are true, they, nevertheless, exhibit nonclassicality when used as a computational resource—an imprint of their quantum origin.

Hoban, Matty J.; Wallman, Joel J.; Anwar, Hussain; Usher, Naïri; Raussendorf, Robert; Browne, Dan E.



Teaching Classical Mechanics Using Smartphones  

ERIC Educational Resources Information Center

A number of articles published in this column have dealt with topics in classical mechanics. This note describes some additional examples employing a smartphone and the new software iMecaProf. Steve Jobs presented the iPhone as "perfect for gaming." Thanks to its microsensors connected in real time to the numerical world, physics…

Chevrier, Joel; Madani, Laya; Ledenmat, Simon; Bsiesy, Ahmad



State-dependent classical potentials  

NASA Astrophysics Data System (ADS)

Since the inception of quantum mechanics, the classical limit has been an area of unease. Explanations proposed on this matter include the usage of Plank's constant, the decoherence parameter of the master's equation, or the quantum potential of Bohm's theory. An equally obscure related topic is the mixing of classical and quantum quantities in the dynamical equations. In this thesis, the subject of classical-quantum mixing will be studied. A method will be explored which will demonstrate one of several candidate methods whereby mixing may be removed and replaced by fully quantum non-relativistic equations. Through use of the quantum potential concept and the Feynman path integral, state-dependent forms of the classical scalar and vector potentials will be derived by assuming the existence of separate component wave functions for the particle and potential. The specific wave component psi e attributed to the potential, will hold the effects of an environment. The resulting equations are devoid of classical potentials and can therefore be considered as purely quantum---no mixing takes place. The standard classical potentials emerge from the state-dependent equations by a condition which will be referred to as state-dependence reduction (SDR). Through SDR, the semi-quantum and purely quantum equations are qualitatively and quantitatively equivalent. The new purely quantum equations will be used both to interpret gauge symmetry and to clarify the reasoning behind the Aharonov-Bohm effect. It will be argued that the freedom of gauge is related to the freedom to choose from many different and distinct environments which reproduce the same experimental outcome. Likewise, the AB-effect is understood through the environment from which the topological structure of the electromagnetic field is represented. Several aspects of the environment responsible for the effective potentials will be calculated numerically for well-known physical situations including one-dimensional scattering, two-dimensional double-slit setup, two-dimensional Aharonov-Bohm effect, and the two-dimensional Dirac equation. The proposal of using state-dependent potentials to replace the semi-quantum equation represents a consistent generalization and unification of the quantum and classical potentials, and may offer some experimental results yet untapped.

D'Amico, Mario


Treatment of patients with minimal stage IIIA Hodgkin's disease  

SciTech Connect

Treatment recommendations for patients with upper abdominal Stage IIIA Hodgkin's (III1A) disease have varied widely. The current study reports on a combined institutional retrospective review of 85 patients with surgically staged III1A Hodgkin's disease. Twenty-two patients received combined modality therapy (CMT), 36 patients were treated initially with total nodal irradiation (TNI), and 27 with mantle and para-aortic radiotherapy (MPA). Patients treated with CMT had an actuarial 8-year freedom from relapse (FFR) of 96% as compared to a FFR of 51% in TNI treated patients (p = 0.002), and a FFR of 54% in MPA treated patients (p = 0.004). Of the 11 relapses in MPA treated patients, 7 had a component of their failure in the untreated pelvic or inguinal nodes. The patients treated with CMT had an 8-year actuarial survival of 100% as compared to 79% in TNI treated patients (p = 0.055) and 78% in patients treated with MPA (p = 0.025). Histology and the number of splenic nodules were the most important prognostic variables. Patients with MC/LD histology and greater than or equal to 5 splenic nodules have a high risk of relapse (10/13) when treated with radiation alone (TNI or MPA). We recommend CMT for this group of patients. Patients with NS/LP histology and 1-4 splenic nodules represent a favorable subset of Stage III1A patients. Only 4/21 patients have relapsed and all 21 patients are currently alive without disease regardless of treatment. We currently feel that patients with Stage III1A Hodgkin's disease with NS/LP histology and splenic disease limited to 1-4 nodules are good candidates for MPA as an alternative to TNI or CMT.

Powlis, W.D.; Mauch, P.; Goffman, T.; Goodman, R.L.



FPA micro spectral imaging of non-Hodgkin lymphomas  

NASA Astrophysics Data System (ADS)

A FT-IR microspectroscopy study on reactive lymph nodes and non-Hodgkin lymphomas is reported. Mid infrared absorption spectra collected at diffraction limit spatial resolution from reactive and neoplastic lymph nodes resulted sufficiently different once analysed by multivariate pattern recognition analysis to distinguish tumoral from non tumoral samples. The potential of infrared spectroscopy as a post-operative screening is gained by the use of a multielement Focal Plane Array detector. Spectral differences between normal and malignant spectra were mainly in the methyl stretching and in the low frequency region.

Burattini, E.; Malvezzi-Campeggi, F.; Chilosi, M.; Conti, C.; Ferraris, P.; Monti, F.; Sabbatini, S.; Tosi, G.; Zamò, A.



Obesity and risk of non-Hodgkin lymphoma (United States)  

Microsoft Academic Search

Objective  Few studies have explored the potential association between body mass index (BMI) and non-Hodgkin lymphoma (NHL) according\\u000a to histologic subtypes, or have evaluated BMI at different periods in the subject’s life, and the results of these studies\\u000a have been inconsistent.\\u000a \\u000a \\u000a \\u000a Subjects  A population-based, case–control study of 387 patients with NHL and 535 controls conducted in Nebraska between 1999 and 2002.\\u000a \\u000a \\u000a \\u000a Methods  Information

Brian C.-H. Chiu; Lori Soni; Susan M. Gapstur; Angela J. Fought; Andrew M. Evens; Dennis D. Weisenburger



Alcohol consumption and non-Hodgkin lymphoma survival  

Microsoft Academic Search

Introduction  Epidemiological studies have shown that moderate alcohol drinkers have a lower death rate for all causes. Alcohol drinking\\u000a has also been associated with reduced risk of non-Hodgkin lymphoma (NHL). Here, we examined the role of alcohol consumption\\u000a on NHL survival by type of alcohol consumed and NHL subtype.\\u000a \\u000a \\u000a \\u000a \\u000a Methods  A cohort of 575 female NHL incident cases diagnosed during 1996–2000 in

Xuesong Han; Tongzhang Zheng; Francine M. Foss; Shuangge Ma; Theodore R. Holford; Peter Boyle; Brian Leaderer; Ping Zhao; Min Dai; Yawei Zhang



Ileocolic intussusception secondary to Hodgkin's lymphoma. Report of a case.  


Intussusception is a rare condition in adults and represents 1% to 5% of the total cases of intestinal obstruction. Preoperative diagnosis occurs only in a few patients and most of the cases are diagnosed during surgery. A demonstrable etiology is found in 70% to 90% of cases in adult intussusceptions, and approximately 40% of them are caused by primary or secondary malignant tumors. We report the case of a 32 year old male patient with an ileocolic intussusception secondary to Hodgkin's lymphoma, as well as the surgical treatment, and outcome. PMID:21592909

Luque-de-León, E; Sánchez-Pérez, M A; Muñoz-Juárez, M; Cordera-González de Cosío, F; Moreno-Paquentin, E; Toledo-Valdovinos, S



Early intensification treatment approach in advanced-stage Hodgkin lymphoma.  


The key question in advanced-stage Hodgkin lymphoma for many years now has been, should intensified chemotherapy be applied upfront or be reserved for relapsing patients. The early intensification approach with BEACOPP(escalated) (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) aims at curing patients with first-line chemotherapy definitely. The added toxicity of this approach as compared to less intensive regimens as ABDV (doxorubicin, bleomycin, dacarbazine, vinblastine) is mainly restricted to acute haematotoxicity and gonadal damage. However, regarding efficacy, there is a meaningful survival-benefit over ABVD (10% at 5years) and the intensified first-line treatment strategy is thus rightly regarded as standard of care. PMID:24287068

Borchmann, Peter



[Malignant pleural mesothelioma after radiation treatment for Hodgkin lymphoma].  


Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the role of ionizing radiation is more controversial. We report the case of a 41-year-old male who developed pleural mesothelioma. He had both, a prior short asbestos exposure and a thoracic radiotherapy for Hodgkin's disease 26years before. The evidence for radiotherapy as cause for mesothelioma is expanding and the diagnosis of mesothelioma in patients who had previous irradiation should be kept in mind. PMID:23796498

Vandenbos, F; Figueredo, M; Dumon-Gubeno, M-C; Nicolle, I; Tarhini, A; Butori, C; Mouroux, J



Pediatric Hodgkin Lymphoma, the Rationale for Radiation Therapy  

Microsoft Academic Search

\\u000a The challenge in pediatric Hodgkin lymphoma (HL) is to continue progress in its curability while diminishing the risk for\\u000a delayed toxicities that has undermined this progress. Pediatric HL is highly curable, with a 10-year actuarial survival rate\\u000a of 85–97% in early-stage disease, and 70–90% in advanced-stage disease. The most profound morbidities that prompted trials\\u000a of combined chemotherapy and low-dose radiation

David C. Hodgson; Melissa M. Hudson; Louis S. Constine


Anterior visual system involvement in non-Hodgkin's lymphoma.  

PubMed Central

Non-Hodgkin's lymphoma may have ocular involvement but optic nerve and chiasmal disease is unusual. Determining the cause of the neuropathy in this group of patients presents major difficulties despite modern neuroimaging and immunocytochemistry. Two patients with NHL are presented; one had an anterior chiasmal syndrome and the other bilateral optic nerve involvement. The first patient was thought to have lymphomatous infiltration and the second a concomitant infection (progressive multifocal leucoencephalopathy). Toxic effects of therapy were considered but finally rejected. The importance of modern neuroimaging and the role of optic nerve biopsy are discussed. Images

Zaman, A G; Graham, E M; Sanders, M D



Chinese Historical Society  

NSDL National Science Digital Library

Archaeological digs can tell us much about ancient civilizations, but what about more recent periods of human habitation? This fine collection from the USC Digital Library presents over 1,100 images of artifacts excavated from two sites in Southern California. The Chinatown section features 1,040 color images of artifacts from the original Los Angeles Chinatown. These items were recovered during the construction of the Metro Rail Red Line by the Los Angeles County Metropolitan Transportation Authority. The online collection includes photos of wine bowls, ink stone boxes, and other fragments of items from daily household life. The second segment includes items excavated in 1992 from an old adobe structure in Santa Barbara that housed a Chinese laundry from the mid 1880s to 1905. The collection can be searched via keyword, and it is quite a resource for historians, archaeologists, and others.



Use of Traditional Chinese Medicine by older Chinese immigrants in Canada  

Microsoft Academic Search

Results. The response rate was 77%. Over two-thirds of the older Chinese immigrants reported using TCM in combination with WHS. About half (50.3%) of the older Chinese immigrants used Chinese herbs, 48.7% used Chinese herbal formulas, and 23.8% consulted a Chinese herbalist. Although separate analysis was conducted, similar predictors were identified. Country of origin, Chinese health beliefs, social support, city

Daniel Lai


Writing Chinese and mathematics achievement: A study with Chinese-American undergraduates  

Microsoft Academic Search

Two recent studies indicated that writing Chinese is correlated to Chinese-American (CA) students’ spatial skills. The current\\u000a study investigated whether writing Chinese would have the same relationship to mathematics skills. The Scholastic Assessment\\u000a Test—Mathematics (SAT-Math) scores were analysed for 150 CA undergraduates: 42 writers of Chinese and 108 non-writers of Chinese.\\u000a The results suggested a strong correlation between writing Chinese

Chieh Li; Ronald Nuttall



Chinese Nonwovens Filter Media Market  

Microsoft Academic Search

Here, Dr Wang Yanxi, chairman of the China Nonwovens Technical Association (CNTA) talks about the Chinese nonwovens filter media industry, its history, development, applications and growth potential over the next 5–10 years.

Wang Yanxi



Atypical prediagnosis Epstein-Barr virus serology restricted to EBV-positive Hodgkin lymphoma  

PubMed Central

An altered anti–Epstein-Barr virus (EBV) serologic profile preceding diagnosis is associated with an increased risk of Hodgkin lymphoma. It is unknown whether this atypical pattern predicts Hodgkin lymphoma risk further subdivided by determination of EBV in tumor cells. A nested case-control study of 128 incident Hodgkin lymphoma cases and 368 matched controls from active-duty military personnel with archived serum in the US Department of Defense Serum Repository was conducted to determine whether a panel of anti-EBV antibody titers differed in EBV+ and EBV? Hodgkin lymphoma. Among 40 EBV+ Hodgkin lymphoma cases and matched controls, statistically significant increased risks were associated with elevated anti-EBV VCA IgG antibody titers (relative risk = 3.1; 95% confidence interval [CI], 1.1-8.7), and an anti–EBNA-1/anti–EBNA-2 antibody ratio ? 1.0 versus > 1.0 (relative risk = 4.7; 95% CI, 1.6-13.8). In contrast, no significant associations were found among 88 EBV? Hodgkin lymphoma cases relative to their matched controls. In case-case analysis, EBV+ disease was significantly associated with a low anti–EBNA-1/anti–EBNA-2 antibody ratio. This distinc-tive serologic response to EBV latent antigens, indicative of immune dysfunction in other clinical settings, is associated with an increased risk of developing EBV+ but not EBV? Hodgkin lymphoma.

Chang, Ellen T.; Ambinder, Richard F.; Lennette, Evelyne T.; Rubertone, Mark V.; Mann, Risa B.; Borowitz, Michael; Weir, Edward G.; Abbondanzo, Susan L.; Mueller, Nancy E.



Bulimia nervosa in the Chinese.  


Typical DSM-III-R bulimia nervosa with self-induced vomiting was found in 2 women of Hong Kong Chinese origin and a Chinese man from Malaysia. All 3 cases had a family history of obesity. In 2 of the cases a period of weight gain and in the third case frank obesity preceded the onset of the eating disorder. Cultural transition seemed to play an important part in the onset and maintenance of the eating disorder. PMID:8293034

Schmidt, U



Serum IgA to Epstein-Barr virus Early Antigen-Diffuse identifies Hodgkin's lymphoma.  


Hodgkin's lymphoma is associated with immune dysregulation. Immune impairment often results in aberrant immune responses and lytic reactivation of ubiquitous Herpesviruses, such as Epstein-Barr virus (EBV) in mucosal tissues. Accordingly, the specificity of IgA to EBV early lytic antigens, which are important for reactivation, was evaluated to determine Hodgkin's lymphoma-specific sero-reactive patterns. Sera from 42 patients with Hodgkin's lymphoma were compared to sera from 17 patients with infectious mononucleosis (IM), another EBV-related condition that often presents in a similar manner; and to sera from 15 healthy EBV-seropositive subjects. Flow cytometry analysis demonstrated that like IM sera, most Hodgkin's lymphoma sera contained IgA that labeled cells expressing EBV early lytic antigens whereas healthy EBV-seropositive sera did not. Further evaluation to distinguish Hodgkin's lymphoma from IM showed that IgA in most Hodgkin's lymphoma, irrespective of the presence of EBV in primary tumors, detected only modified forms of EBV lytic Early Antigen-Diffuse (EA-D) while IM sera detected the un-modified form as well, further supporting the presence of immune dysregulation in Hodgkin's lymphoma patients. This IgA pattern distinguished Hodgkin's lymphoma from IM sera with a sensitivity of 92.9%, specificity 100%, positive predictive value 100%, and negative predictive value 85%. Our findings lay the groundwork for additional scientific and clinical investigation, particularly into the potential for developing Hodgkin's lymphoma-associated diagnostic and prognostic biomarkers. J. Med. Virol. 86:1621-1628, 2014. © 2013 Wiley Periodicals, Inc. PMID:24122847

McAllister, Shane C; Shedd, Duane; Mueller, Nancy E; Chang, Ellen T; Miller, George; Bhaduri-McIntosh, Sumita



Human Herpes Viruses Are Associated with Classic Fever of Unknown Origin (FUO) in Beijing Patients  

PubMed Central

Background Few reports have examined the viral aetiology of fever of unknown origin (FUO). Objective This study determined the prevalence of human herpes virus (HHV) DNA in blood of Chinese patients with classic FUO using the polymerase chain reaction (PCR) and explored the possible role of HHV. Study design Blood samples were collected from 186 patients (151 children, 35 adults) with classic FUO and 143 normal individuals in Beijing during the years 2009–2012. The HHV DNA, including Herpes simplex virus (HSV)-1/2, Varicella zoster virus (VZV), Cytomegalovirus (CMV), Epstein–Barr virus (EBV), and Human herpes virus (HHV)-6 and -7, was detected by multiplex PCR. The epidemiological and clinical features were also analysed. Results HHV DNA was detected in 63 (33.9%) of the FUO patients, and the prevalence of EBV and HHV-6 was significantly higher than in the normal cohort. HHV co-infection was also frequent (10.2%) in the patients with FUO. The majority of patients with HHV infection present with a fever only. Our data also revealed that EBV infection was associated with hepatitis and abnormal blood indices, HHV-6 was associated with a cough, and HHV-7 was associated with hepatitis. Conclusions HHVs are associated with Chinese patients (especially for children) with classic FUO. Our study adds perspective to the aetiological and clinical characteristics of classic FUO in beijing patients.

Zhou, Weimin; Tan, Xinyi; Li, Yamin; Tan, Wenjie



Conversion Of Classical Orbital Elements  

NASA Technical Reports Server (NTRS)

OSMEAN is sophisticated program that converts between osculating and mean classical orbital elements. Enables engineer to exploit advantages of each approach for design and planning or orbital trajectories and maneuvers. Converts mean elements to osculating elements or vice-versa. Conversion based on mathematical modeling of all first-order aspherical terrestrial, lunar, and solar gravitational perturbations plus second-order aspherical term based on second-degree central-body zonal perturbation. Written in FORTRAN 77.

Guinn, Joseph R.; Bhat, Ramachand S.; Vincent, Mark A.; Konopliv, Alexander S.



Invariants from classical field theory  

SciTech Connect

We introduce a method that generates invariant functions from perturbative classical field theories depending on external parameters. By applying our methods to several field theories such as Abelian BF, Chern-Simons, and two-dimensional Yang-Mills theory, we obtain, respectively, the linking number for embedded submanifolds in compact varieties, the Gauss' and the second Milnor's invariant for links in S{sup 3}, and invariants under area-preserving diffeomorphisms for configurations of immersed planar curves.

Diaz, Rafael [Grupo de Fisica-Matematica, Universidad Experimental Politecnica de las Fuerzas Armadas, Caracas 1010 (Venezuela); Leal, Lorenzo [Centro de Fisica Teorica y Computacional, Universidad Central de Venezuela, Caracas 1041-A (Venezuela)



DW3 Classical Music Resources  

NSDL National Science Digital Library

This site, hosted by the Duke University Music Library, is a sizable and well-organized metasite for classical music resources. Sections include Composer Homepages, Chronologies and Necrologies, National and Regionally Oriented Pages, Organizations and Centers for Scholarly Research, Electronic Journals and Newsletters, Genre-Specific Pages, and Databases (over 40). With the exception of the Chronologies and Necrologies and Databases sections, the featured links are not annotated. An internal search engine is also provided.


Applications of classical detonation theory  

SciTech Connect

Classical detonation theory is the basis for almost all calculations of explosive systems. One common type of calculation is of the detailed behavior of inert parts driven by explosive, predicting pressures, velocities, positions, densities, energies, etc as functions of time. Another common application of the theory is predicting the detonation state and expansion isentrope of a new explosive or mixtures, perhaps an explosive that has not yet been made. Both types of calculations are discussed.

Davis, W.C.



Quantum fields with classical perturbations  

NASA Astrophysics Data System (ADS)

The main purpose of these notes is a review of various models of Quantum Field Theory (QFT) involving quadratic Lagrangians. We discuss scalar and vector bosons, spin 1/2 fermions, both neutral and charged. Beside free theories, we study their interactions with classical perturbations, called, depending on the context, an external linear source, mass-like term, current or electromagnetic potential. The notes may serve as a first introduction to QFT.

Derezi?ski, Jan



Classical foundations of quantum logic  

Microsoft Academic Search

We construct a languageL for a classical first-order predicate calculus with monadic predicates only, extended by means of a family of statistical quantifiers. Then, a formal semantic model\\u000a$$\\\\mathfrak{M}$$\\u000a is put forward forL which is compatible with a physical interpretation and embodies a truth theory which provides the statistical quantifiers with properties that fit their interpretation; in this framework, the

Claudio Garola



Tumor lysis syndrome in children with non-Hodgkin lymphoma.  


This study was designed to evaluate the incidence of tumor lysis syndrome (TLS) among children with non-Hodgkin lymphoma and to define whether renal involvement can be associated with higher incidence of TLS after chemotherapy. Medical charts of 59 patients were reviewed. TLS was diagnosed using laboratory and clinical criteria. Renal involvement was diagnosed based on ultrasound and CT scan findings. Laboratory TLS occurred in 7 patients (11.85%) and clinical TLS was observed in 7 patients (11.85%) as well. In 5 out of 14 TLS patients, hemodialysis was required to correct electrolyte abnormalities and TLS related death was reported overall in 3 patients. Sex, age, pretreatment LDH, and initial WBC count were not associated with higher incidence of TLS after chemotherapy, but a significant correlation was found between pretreatment renal involvement at imaging studies and development of TLS after chemotherapy (p = .027). The results indicate that despite all preventive measures, tumor lysis syndrome still occurs in children with non-Hodgkin lymphoma following chemotherapy. Patients who have evidence of renal involvement at imaging studies are more likely to develop TLS after chemotherapy. PMID:16326415

Alavi, Samin; Arzanian, Mohammad Taghi; Abbasian, Mohammad Reza; Ashena, Zahra



Plasma Biomarkers for Detecting Hodgkin's Lymphoma in HIV Patients  

SciTech Connect

The lifespan of AIDS patients has increased as a result of aggressive antiretroviral therapy, and the incidences of the AIDS-defining cancers, Hodgkin's lymphoma and Kaposi sarcoma, are declining, Still, the increased longevity of AIDS patients is now associated with increased incidence of other cancers, including Hodgkin's lymphoma (HL). In order to determine if we could identify biomarkers for the early detection of HL, we undertook an accurate mass and elution time tag proteomics analysis of individual plasma samples from AIDS patients without HL (n=14) and with HL (n=22). This analysis identified 33 proteins, included C-reactive protein and three serum amyloid proteins, that were statistically (p<0.05) altered by at least 1.5-fold between the two groups. At least three of these proteins have previously been reported to be altered in the blood of HL patients. Ingenuity Pathway Analysis software identified 'inflammatory response' and 'cancer' as the top two, biological functions commonly associated with these proteins. The clear association of these proteins with cancer and inflammation suggests that they are truly associated with HL and that they would be useful in the detection of this disease.

Varnum, Susan M.; Webb-Robertson, Bobbie-Jo M.; Hessol, Nancey; Smith, Richard D.; Zangar, Richard C.



Electron microscopy in the non-Hodgkin's lymphomata.  

PubMed Central

The component cells of peripheral lymphoid tissue have been divided into the lymphocyte and plasma cell lines, mononuclear phagocytic cells, dendritic "reticular cells", the reticular (supporting) cells and endothelial cells, and it is suggested that this system of cells should collectively be referred to as the lymphoreticular monoclear phagocyte system or LRMPS. Seventeen tumours of the LRMPS (excluding Hodgkin's disease) have been studied at ultrastructural level. Of these 17 non-Hodgkin lymphomata 5 were follicular lymphomata and 12 diffuse. It is concluded that electron microscopy plays a valuable role in the diagnosis of this group of tumours. Not only does it allow rejection of a diagnosis of lymphoma in certain anaplastic tumours, but it also enables a more precise identification of the cellular components of a lymphoma as well as indicating the degree of differentiation of the cell line involved. Additional advantages are the visualization of subcellular structures useful as markers, and by means of specialized immunoelectron microscopic techniques the identification of antigens and antibody formation within a given tumour. Two other results of this ultrastructural study are the indication that the dendritic cells of lymphoid follicles are derived from capillary endothelium, and the identification of certain anomalous formations derived from rough endoplasmic reticulum in the case of tumours showing plasmacytoid differentiation. Images Fig. 1 Fig. 2 Fig. 3 Fig. 4 Fig. 5 Fig. 6 Fig. 7 Fig. 8 Fig. 9 Fig. 10 Fig. 11 Fig. 12 Fig. 13 Fig. 14 Fig. 15

Henry, K.



Vitamin D3 receptor is highly expressed in Hodgkin's lymphoma  

PubMed Central

Background Hodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as a possible diagnostic marker and potential therapeutic target in HL as well as in B-cell derived non-Hodgkin lymphoma (B-NHL). Methods We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of HL and 138 cases on several B-NHL entities. Results Vitamin D receptor is strongly expressed in tumor cells of HL, regardless of the sub entity with an overall positivity of 80% of all HL cases. In contrast, only about 17% of the analyzed origin-NHL showed positivity for vitamin D receptor. The detection of nuclear localization of vitamin D receptor in the tumor cells of HL suggests activated status of the vitamin D receptor. Conclusions Our study suggests VDR as a specific marker for tumor cells of HL, but not of B-NHL subtypes. Further, the observed nuclear localization suggests an activated receptor status in tumor cells of HL. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in HL.



Pericarditis and myocardial infarctions after Hodgkin's disease therapy  

SciTech Connect

From 1971 to 1984, 499 patients with all stages of Hodgkin's disease received mediastinal irradiation at the Institut Gustave-Roussy by 25 MV photons from a linear accelerator. Thirty-five pericarditis (10-year cumulative incidence rate of 9.5%) and 13 myocardial infarctions (MI) (10-year cumulative incidence rate of 3.9%) were observed. In contrast, no cases were diagnosed in a parallel series of 138 Hodgkin's disease patients treated without mediastinal irradiation during the same period of time (p less than 0.005 for pericarditis, p less than 0.05 for MI). By multivariate analysis, the role of total radiation dose given to the mediastinum and that of fraction size were evaluated, adjusting for age, sex, mediastinal involvement, and type of chemotherapy. The pericarditis risk was significantly increased with total dose greater than or equal to 41 Gy (relative risk (RR) = 3.25, p = 0.006) and with dose per fraction greater than or equal to 3.0 Gy (RR = 2.0, p = 0.06). The myocardial infarction risk was not found to be related to total dose nor to fraction size in this series, possibly because of the small number of events.

Cosset, J.M.; Henry-Amar, M.; Pellae-Cosset, B.; Carde, P.; Girinski, T.; Tubiana, M.; Hayat, M. (Department of Radiation Oncology, Institut Gustave-Roussy, Villejuif (France))



Rituximab as potential therapy for paraneoplastic cerebellar degeneration in pediatric Hodgkin disease.  


Paraneoplastic cerebellar degeneration (PCD) is a rare neurological syndrome associated with lung cancer, breast adenocarcinoma,ovarian adenocarcinoma, and Hodgkin disease. It is rarely seen in pediatrics. We report a case of a 10-year-old boy with a 2-year prodrome that led to a diagnosis of PCD in association with stage IV Hodgkin disease. He received radiation and chemotherapy for his Hodgkin disease with resolution of his lymphoma. Based on promising data in adults on the efficacy of rituximab over other immuno suppressive agents in paraneoplastic disorders, he was treated with rituximab with marked improvement of the cerebellar syndrome. PMID:22532986

Yeo, Kee Kiat; Walter, Andrew W; Miller, Robin E; Dalmau, Josep



Entanglement in the classical limit: Quantum correlations from classical probabilities  

SciTech Connect

We investigate entanglement for a composite closed system endowed with a scaling property which allows the dynamics to be kept invariant while the effective Planck constant ({Dirac_h}/2{pi}){sub eff} of the system is varied. Entanglement increases as ({Dirac_h}/2{pi}){sub eff}{yields}0. Moreover, for sufficiently low ({Dirac_h}/2{pi}){sub eff} the evolution of the quantum correlations, encapsulated, for example, in the quantum discord, can be obtained from the mutual information of the corresponding classical system. We show this behavior is due to the local suppression of path interferences in the interaction that generates the entanglement.

Matzkin, A. [LPTM (CNRS Unite 8089), Universite de Cergy-Pontoise, F-95302 Cergy-Pontoise Cedex (France)



Three-dimensional Telomere Signatures of Hodgkin- and Reed-Sternberg Cells at Diagnosis Identify Patients with Poor Response to Conventional Chemotherapy1  

PubMed Central

In classic Hodgkin lymphoma (HL) the malignant mononuclear Hodgkin (H) and multinuclear Reed-Sternberg (RS) cells are characterized by a distinct three-dimensional nuclear telomere organization with shortening of the telomere length and the formation of telomeric aggregates. We asked if the severity of these telomere changes correlates with the clinical behavior of the disease. We retrospectively evaluated three-dimensional telomere organization by quantitative fluorescent in situ hybridization (Q-FISH) of diagnostic biopsies from 16 patients who were good responders and compared them with 16 diagnostic biopsies of 10 patients with refractory or relapsing HL (eight initial biopsies, four confirming progressions, and four confirming relapses). The H cells from patients with refractory/relapsing disease contained a significantly higher percentage of very small telomeres (P = .027) and telomere aggregates (P = .032) compared with H cells of patients entering rapid remission. These differences were even more significant (P = .002 and P = .013, respectively) when comparing the eight initial diagnostic biopsies of refractory/relapsing HL with diagnostic biopsies of eight patients with ongoing long-lasting remission (mean of 47 months). This specific three-dimensional telomere Q-FISH signature identifies these highly aggressive mononuclear H cells at the first diagnostic biopsy and thus may offer a new molecular marker to optimize initial treatment.

Knecht, Hans; Kongruttanachok, Narisorn; Sawan, Bassem; Brossard, Josee; Prevost, Sylvain; Turcotte, Eric; Lichtensztejn, Zelda; Lichtensztejn, Daniel; Mai, Sabine



SB-715992 in Treating Patients With Metastatic or Unresectable Solid Tumors or Hodgkin's or Non-Hodgkin's Lymphoma

Adult Grade III Lymphomatoid Granulomatosis; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia



Polymorphic variation in NFKB1 and other aspirin-related genes and risk of Hodgkin lymphoma.  


We found that regular use of aspirin may reduce the risk of Hodgkin lymphoma (HL), a common cancer of adolescents and young adults in the United States. To explore possible biological mechanisms underlying this association, we investigated whether polymorphic variation in genes involved in nuclear factor-kappaB (NF-kappaB) activation and inhibition, other inflammatory pathways, and aspirin metabolism influences HL risk. Twenty single nucleotide polymorphisms (SNP) in seven genes were genotyped in DNA from 473 classical HL cases and 373 controls enrolled between 1997 and 2000 in a population-based case-control study in the Boston, Massachusetts, metropolitan area and the state of Connecticut. We selected target genes and SNPs primarily using a candidate-SNP approach and estimated haplotypes using the expectation-maximization algorithm. We used multivariable logistic regression to estimate odds ratios (OR) for associations with HL risk. HL risk was significantly associated with rs1585215 in NFKB1 (AG versus AA: OR, 2.1; 95% confidence interval, 1.5-2.9; GG versus AA: OR, 3.5; 95% confidence interval, 2.2-5.7, Ptrend=1.7x10(-8)) and with NFKB1 haplotypes (Pglobal=6.0x10(-21)). Similar associations were apparent across categories of age, sex, tumor EBV status, tumor histology, and regular aspirin use, although statistical power was limited for stratified analyses. Nominally significant associations with HL risk were detected for SNPs in NFKBIA and CYP2C9. HL risk was not associated with SNPs in IKKA/CHUK, PTGS2/COX2, UDP1A6, or LTC4S. In conclusion, genetic variation in the NF-kappaB pathway seems to influence risk of HL. Pooled studies are needed to detect any heterogeneity in the association with NF-kappaB across HL subgroups, including aspirin users and nonusers. PMID:19223558

Chang, Ellen T; Birmann, Brenda M; Kasperzyk, Julie L; Conti, David V; Kraft, Peter; Ambinder, Richard F; Zheng, Tongzhang; Mueller, Nancy E



Epstein-Barr virus-positive nodular lymphocyte predominant Hodgkin lymphoma.  


Hodgkin lymphoma (HL) is classified into 2 largely distinct subgroups, namely nodular lymphocyte predominant HL (NLPHL) and classic HL (CHL). CHL is further divided into nodular sclerosis, lymphocyte-rich, mixed cellularity (MCCHL) and lymphocyte-depleted (LDCHL) subtypes. In industrialized nations, Epstein-Barr virus (EBV) has been associated with all types of CHL, especially the MCCHL and LDCHL subtypes, but is rare in NLPHL. We report 8 cases of EBV-positive NLPHL occurring in patients in the United States. All 8 patients have no history of immunosuppression and presented with localized or systemic lymphadenopathy. Histologically, 6 cases had a vaguely nodular pattern and 2 cases had a nodular and diffuse pattern. In all cases, lymphocyte predominant (LP) cells were observed in a background of small lymphocytes and histiocytes. Immunohistochemical analysis showed that the LP cells in all cases were positive for CD20, CD79a, PAX5, OCT2, and CD45 and were negative for CD15. CD30 was expressed variably in 7 cases. EBV encoded RNA was present in all LP cells in 5 cases and in a subset of LP cells in 3 cases. One patient was treated with radiation therapy and 7 patients received chemotherapy, including 4 of 7 patients who underwent autologous stem cell transplantation. EBV infection is a rare primary or secondary event in NLPHL that correlates with poorer prognosis and often requires more aggressive therapy. The variable expression of CD30 in most of these cases could be the result of EBV infection. PMID:24852241

Wang, Shi; Medeiros, L Jeffrey; Xu-Monette, Zijun Y; Zhang, Shanxiang; O'Malley, Dennis P; Orazi, Attilio; Zuo, Zhuang; Bueso-Ramos, Carlos E; Yin, Cameron C; Liu, Zhiyu; Miranda, Roberto N; Young, Ken H



Three approaches to classical thermal field theory  

SciTech Connect

Research Highlights: > Classical thermal field theory admits three equivalent path integral formulations. > Classical Feynman rules can be derived for all three formulations. > Quantum Feynman rules reduce to classical ones at high temperatures. > Classical Feynman rules become much simpler when superfields are introduced. - Abstract: In this paper we study three different functional approaches to classical thermal field theory, which turn out to be the classical counterparts of three well-known different formulations of quantum thermal field theory: the closed-time path (CTP) formalism, the thermofield dynamics (TFD) and the Matsubara approach.

Gozzi, E., E-mail: [Department of Physics, University of Trieste, Strada Costiera 11, Miramare - Grignano, 34151 Trieste (Italy); INFN, Sezione di Trieste (Italy); Penco, R., E-mail: [Department of Physics, Syracuse University, Syracuse, NY 13244-1130 (United States)



Chinese Ischemic Stroke Subclassification  

PubMed Central

Accurate classification of stroke has significant impact on patient care and conduction of stroke clinical trials. The current systems such as TOAST, SSS-TOAST, Korean TOAST, and A–S–C–O have limitations. With the advent of new imaging technology, there is a need to have a more accurate stroke subclassification system. Chinese ischemic stroke subclassification (CISS) system is a new two step system aims at the etiology and then underlying mechanism of a stroke. The first step classify stroke into five categories: large artery atherosclerosis (LAA), including atherosclerosis of aortic arch and intra-/extracranial large arteries, cardiogenic stroke, penetrating artery disease, other etiology, and undetermined etiology. The second step is to further classify the underlying mechanism of ischemic stroke from the intracranial and extracranial LAA into the parent artery (plaque or thrombosis) occluding penetrating artery, artery-to-artery embolism, hypoperfusion/impaired emboli clearance, and multiple mechanisms. Although clinical validation of CISS is being planned, CISS is an innovative system that offers much more detailed information on the pathophysiology of a stroke.

Gao, S.; Wang, Y. J.; Xu, A. D.; Li, Y. S.; Wang, D. Z.