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1

Immunological Deregulation in Classic Hodgkin Lymphoma  

PubMed Central

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications. PMID:24959336

Romano, Alessandra; Vetro, Calogero; Caocci, Giovanni; Greco, Marianna; Parrinello, Nunziatina Laura; Di Raimondo, Francesco; La Nasa, Giorgio

2014-01-01

2

Immunological deregulation in classic hodgkin lymphoma.  

PubMed

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications. PMID:24959336

Romano, Alessandra; Vetro, Calogero; Caocci, Giovanni; Greco, Marianna; Parrinello, Nunziatina Laura; Di Raimondo, Francesco; La Nasa, Giorgio

2014-01-01

3

Classical Hodgkin’s lymphoma shows epigenetic features of abortive plasma cell differentiation  

PubMed Central

Background Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin’s lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin’s lymphoma and plasma cell myeloma, both of which share extinction of the gene expression program of mature B cells. Design and Methods Global histone H3 acetylation patterns were determined in cell lines derived from classical Hodgkin’s lymphoma, plasma cell myeloma and B-cell lymphoma by chromatin immunoprecipitation and subsequent hybridization onto promoter tiling arrays. H3K27 trimethylation was analyzed by chromatin immunoprecipitation and real-time DNA polymerase chain reaction for selected genes. Epigenetic modifications were compared to gene expression data. Results Characteristic B-cell genes were hypoacetylated in classical Hodgkin’s lymphoma and plasma cell myeloma cell lines as demonstrated by comparison of their histone H3 acetylation patterns to those of B-cell lines. However, the number of genes jointly hyperacetylated and expressed in classical Hodgkin’ lymphoma and plasma cell myeloma cell lines, such as IRF4/MUM1 and RYBP, is limited. Moreover, H3K27 trimethylation for selected characteristic B-cell genes revealed that this additional epigenetic silencing is much more prevalent in classical Hodgkin’s lymphoma than in plasma cell myeloma. Conclusions Our epigenetic data support the view that classical Hodgkin’s lymphoma is characterized by abortive plasma cell differentiation with a down-regulation of characteristic B-cell genes but without activation of most genes typical of plasma cells. PMID:21393330

Seitz, Volkhard; Thomas, Philippe E.; Zimmermann, Karin; Paul, Ulrike; Ehlers, Anke; Joosten, Maria; Dimitrova, Lora; Lenze, Dido; Sommerfeld, Anke; Oker, Elisabeth; Leser, Ulf; Stein, Harald; Hummel, Michael

2011-01-01

4

Targeted therapy in relapsed classical hodgkin lymphoma.  

PubMed

Although frontline treatment of advanced Hodgkin lymphoma (HL) produces high cure rates, disease either will not respond to or will relapse after initial therapy in approximately a quarter of patients. Many patients with disease relapse can be successfully salvaged with second-line chemotherapy followed by autologous stem cell transplantation (ASCT). Patients whose disease relapses after ASCT are rarely cured. A unique pathophysiologic feature of HL is that the malignant Reed-Sternberg (HRS) cell is rare and resides within a microenvironment of inflammatory and immune-related cells. The recent FDA approval of the anti-CD30 antibody-drug conjugate brentuximab vedotin (BV) for patients with either primary refractory HL or those whose disease relapses after ASCT represents a major advance in therapy. This article focuses on BV and other novel agents that target the HRS cell surface, intracellular signaling pathways, and tumor microenvironment. PMID:23946175

Dinner, Shira; Advani, Ranjana

2013-08-01

5

Immunohistochemical markers for tumor associated macrophages and survival in advanced classical Hodgkin’s lymphoma  

PubMed Central

A subset of patients with advanced classical Hodgkin’s lymphoma is refractory to standard therapies. Therefore, it is relevant to identify new biologically-based prognostic markers. Recently, tumor associated macrophages have been proposed as a factor that predicts survival, although contradictory results have also been reported. Here we analyzed four macrophage markers (CD68, CD163, LYZ, and STAT1) using immunohistochemistry and automated quantification, in two independent series of advanced classical Hodgkin’s lymphoma (n=266 and 103 patients, respectively). Our results did not confirm that specific macrophage immunohistochemical markers could be used as surrogates for gene expression profiling studies. Survival analyses did not show correlation between CD163, LYZ or STAT1 and either failure-free or disease-specific survival. There was an association between CD68 and disease-specific survival, but it was not consistent in both series. In conclusion, individual tumor associated macrophage markers cannot be used to predict outcome before technical standardization and prospective validation in independent series of patients with comparable stages and treatments. PMID:22315492

Sánchez-Espiridión, Beatriz; Martin-Moreno, Ana M.; Montalbán, Carlos; Medeiros, L. Jeffrey; Vega, Francisco; Younes, Anas; Piris, Miguel A.; Garcia, Juan F.

2012-01-01

6

Development of classical Hodgkin’s lymphoma in an adult with biallelic STXBP2 mutations  

PubMed Central

Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies. Here, we describe an Epstein-Barr virus-positive classical Hodgkin’s lymphoma in a patient harboring biallelic mutations in STXBP2, a gene required for exocytosis of perforin-containing lytic granules and associated with familial hemophagocytic lymphohistocytosis. Cytotoxic T lymphocytes were found infiltrating the tumor, and a high frequency of Epstein-Barr virus-specific cytotoxic T lymphocytes were detected in peripheral blood. However, lytic granule exocytosis and cytotoxicity by cytotoxic T lymphocytes, as well as natural killer cells, were severely impaired in the patient. Thus, the data suggest a link between defective lymphocyte exocytosis and development of lymphoma in STXBP2-deficient patients. Therefore, with regards to treatment of familial hemophagocytic lymphohistocytosis patients with mutations in genes required for lymphocyte exocytosis, it is important to consider both the risks of hemophagocytic lymphohistocytosis and malignancy. PMID:23100279

Machaczka, Maciej; Klimkowska, Monika; Chiang, Samuel C.C.; Meeths, Marie; Müller, Martha-Lena; Gustafsson, Britt; Henter, Jan-Inge; Bryceson, Yenan T.

2013-01-01

7

Novel treatment strategies for patients with relapsed classical Hodgkin lymphoma  

PubMed Central

The treatment of patients with relapsed and refractory Hodgkin lymphoma (HL), especially those who relapse after autologous stem cell transplantation, remains challenging. Patients with HL whose disease relapses after stem cell transplantation are rarely cured with current treatment modalities, and have a median survival is less than 3 years. With no new drugs have been approved by the FDA for HL in more than three decades, there is a clear unmet medical need for drug development for this patients population. New treatment strategies that are based on targeting oncogenic signaling pathways are currently explored. This review will focus on emerging new treatment modalities that are currently under investigation for patients with relapsed classical HL. PMID:20828898

Jona, Adam; Younes, Anas

2011-01-01

8

PROGNOSTIC SIGNIFICANCE OF PRETREATMENT SERUM CYTOKINES IN CLASSICAL HODGKIN LYMPHOMA  

PubMed Central

Purpose: While the International Prognostic Score (IPS) is the gold standard for risk-stratifying patients with classical Hodgkin lymphoma (cHL), these criteria do not accurately predict outcome. As cytokines are critically involved in driving cHL, we tested whether pretreatment serum cytokine levels could provide additional prognostic information. Experimental Design: Thirty cytokines were measured in pretreatment serum from 140 cHL patients and compared with 50 non-lymphoma controls. Patients were followed for event-free and overall survival, and Cox proportional hazards regression models were used to assess the association of individual cytokines and the cytokine profiles with outcome via unadjusted and IPS-adjusted hazard ratios (HR). Results: Twelve cytokines (EGF, FGFb, GCSF, HGF, IL-6, IL-8, IL-12, IL-2R, IP-10, MIG, TNFa and VEGF) were significantly (p<0.05) higher in cHL patients than controls; elevated levels of HGF, IL-6, IL-2R, IP-10 and MIG were all associated with poorer event-free survival (EFS). Only IL-2R (p=0.002) and IL-6 (p<0.001) were independently prognostic. Patients with increased IL-6 and IL-2R had a significantly higher risk of early relapse and death, a finding that remained significant even after IPS-based risk stratification. While elevated IL-6 and IL-2R correlated with the IPS, sCD30 and TARC levels, the 2-cytokine model remained independently predictive of prognosis. Conclusions: Elevated pretreatment serum cytokines are associated with increased disease relapse and inferior survival in cHL. Thus, the pretreatment cytokine profile, particularly serum levels of IL-6 and IL-2R, may be used to identify cHL patients at high risk for early disease relapse. PMID:24141626

Marri, Preethi Reddy; Hodge, Lucy S.; Maurer, Matthew J.; Ziesmer, Steven C.; Slager, Susan L.; Habermann, Thomas M.; Link, Brian K.; Cerhan, James R.; Novak, Anne J.; Ansell, Stephen M.

2013-01-01

9

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma  

PubMed Central

Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma. PMID:24086377

Campos, Antonio Hugo; Vassallo, Jose; Soares, Fernando Augusto

2013-01-01

10

Clinical features and treatment outcomes of Hodgkin's lymphoma in Hong Kong Chinese  

PubMed Central

Introduction Little information is available on the outcomes of Hodgkin's lymphoma in Chinese patients. We analyzed the clinical and histopathological characteristics, treatment types, clinical course and treatment outcomes of Hong Kong Chinese patients. Material and methods Patients with Hodgkin's lymphoma diagnosed from January 1991 to December 2010 were recruited. A retrospective analysis of these patients was performed. Results Sixty-seven Chinese patients (38 males and 29 females) were identified and the median age was 36 (range 16–80). Nodular sclerosis was the most common histology (54%), followed by mixed cellularity (36%). Twenty-four patients had early favorable, 20 patients had early unfavorable and 23 patients had advanced-stage diseases. The most common presentation was palpable lymph node or mass (85%) followed by fever, weight loss, night sweating and mediastinal mass. Ninety percent of patients received chemotherapy and 40% received radiotherapy as consolidation. Seven patients with stage I lymphoma received radiotherapy alone. ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) was the most commonly used chemotherapeutic regimen. Following treatment, 87% of patients achieved complete remission. Six patients relapsed after first remission and 3 achieved second remission after re-induction therapy. The 5-year overall survival of the entire cohort was 89% and the freedom from treatment failure (FFTF) at 5 years was 82%. The 5-year overall survival rate for early favorable, early unfavorable and advanced stages was 95.7%, 95.0% and 74.7%, respectively. Conclusions Despite the relatively low incidence of Hodgkin's lymphoma in Hong Kong Chinese, the treatment outcomes are comparable to Caucasian patients. PMID:25097580

Ng, Ting Ying; Chan, Hay Nun; Lai, Ho Kei; Ha, Chung Yin; Leung, Charlotte; Ng, Celia; Yeung, Yiu Ming; Yip, Sze Fai

2014-01-01

11

The body and its image in classical Chinese aesthetics  

Microsoft Academic Search

Richard Shusterman’s Pragmatist Aesthetics: Living Beauty, Rethinking Art was published in China in 2002. In the preface of the Chinese edition, the author claimed that his tentative idea of soma\\u000a esthetics was encouraged by Chinese philosophy and other ancient Asian philosophy. Shusterman’s background in pragmatist philosophy\\u000a greatly constrains his understanding of the body in classical Chinese aesthetics in that he

Chengji Liu

2008-01-01

12

Advanced-stage nodular lymphocyte predominant Hodgkin lymphoma compared with classical Hodgkin lymphoma: a matched pair outcome analysis.  

PubMed

Due to disease rarity, there is limited information regarding the optimal therapy and outcome for patients with advanced-stage nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL). Forty-two patients with NLPHL by the Revised European-American Lymphoma/World Health Organization classification with advanced-stage disease were identified and paired 1:2 with a matched control with classical Hodgkin lymphoma (CHL) matched by age, gender, stage, decade of diagnosis, and treatment received. The median follow-up was 11.3 years (range, 1.9 to 35.5 years) for NLPHL patients and 10.7 years (range, 1.6 to 26.3 years) for CHL patients. The majority received doxorubicin, bleomycin, vinblastine, and dacarbazine (ABVD)-like chemotherapy. Although the 10-year overall survival (OS) (P = .579) and HL freedom from treatment failure (HL-FFTF) were similar between NLPHL and CHL patients (75% vs 73%; P = .610), the time to progression (TTP), which also includes the development of secondary aggressive lymphoma, was inferior in NLPHL (10-year, 63% vs 73%; P = .040). Splenic involvement was associated with an inferior 10-year TTP in patients treated with ABVD (48% vs 71%; P = .049) and an increased cumulative incidence of secondary aggressive lymphoma (P = .014) providing a rationale for further evaluation of cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab in NLPHL. PMID:24713929

Xing, Katharine H; Connors, Joseph M; Lai, Anky; Al-Mansour, Mubarak; Sehn, Laurie H; Villa, Diego; Klasa, Richard; Shenkier, Tamara; Gascoyne, Randy D; Skinnider, Brian; Savage, Kerry J

2014-06-01

13

Incidence and spectrum of non-Hodgkin lymphoma in Chinese migrants to British Columbia.  

PubMed

The incidence and spectrum of non-Hodgkin lymphoma (NHL) differ between the Chinese and Caucasian populations. Using population-based registries, we studied the pattern of NHL in Chinese migrants to British Columbia (BC). The records of all NHL cases of Chinese descent diagnosed between 1980 and 1997 were retrieved. Age-standardized incidences were calculated by 5-year intervals in terms of age and calendar years and the relative rates were compared between the migrant, Hong Kong and BC populations. The histological distribution of NHL was compared with 4500 consecutive NHL cases diagnosed in the two populations. A total of 211 cases of migrant NHL were identified, with an age-standardized incidence rate of 7.11 per 100 000 per year, compared with the Hong Kong and BC rates of 7.91 [standardized incidence ratio (SIR) = 0.86, P = 0.01] and 11.88 (SIR = 0.56, P < 0.01). The standardized rates of follicular lymphoma remained low, but the incidence of gastric and nasal natural killer/T lymphomas in migrants were lower than expected. Genetic factors appeared to be stronger than environmental factors in governing the overall incidence of NHL in Chinese. However, certain subtypes of lymphoma may show decreased rates in migrants because of environmental factors. PMID:15755282

Au, W Y; Gascoyne, R D; Klasa, R D; Connors, J M; Gallagher, R P; Le, N D; Loong, F; Law, C K; Liang, R

2005-03-01

14

Infused autograft lymphocyte to monocyte ratio predicts survival in classical Hodgkin lymphoma  

PubMed Central

The infused autograft lymphocyte to monocyte ratio (A-LMR) as a surrogate marker of host immunity (ie, absolute lymphocyte count) and CD14+ HLA-DRlow/neg immunosuppressive monocytes (ie, absolute monocyte count) is a prognostic factor for patients with diffuse large B-cell lymphoma after autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if A-LMR can also affect survival post-APHSCT in classical Hodgkin lymphoma. From 1994 to 2012, 183 patients with classical Hodgkin lymphoma who underwent APHSCT were studied. The patients were randomly divided into a training set (n=122) and a validation set (n=61). The receiver operating characteristic and area under the curve identified an A-LMR ?1 as the best cut-off value and validated by the k-fold cross-validation in the training set. Multivariate analysis showed A-LMR to be an independent prognostic factor for survival in the training set. Patients with an A-LMR ?1.0 experienced a superior overall survival (OS) versus patients with an A-LMR <1.0 (median OS not reached versus 40.4 months, 5-year OS rates of 86% [95% CI 72–93] versus 43% [95% CI 28–58], P<0.0001, respectively) in the training set. In the validation set, an A-LMR ?1 showed a median OS of not reached versus 41.4 months for an A-LMR <1, 5-year OS rates of 90% (95% CI 73–97) versus 48% (95% CI 28–68; P<0.0001). A-LMR provides a platform to engineer an autograft versus tumor effect to improve clinical outcomes in patients with classical Hodgkin lymphoma undergoing APHSCT. PMID:25674021

Porrata, Luis F; Inwards, David J; Ansell, Stephen M; Micallef, Ivana N; Johnston, Patrick B; Hogan, William J; Markovic, Svetomir N

2015-01-01

15

Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors  

PubMed Central

Background Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL. Methods The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano staging system for gastrointestinal non-Hodgkin's lymphoma. Results The predominant pathologic subtype among Chinese patients with PGL in our study was diffuse large B cell lymphoma (DLBCL), followed by mucosa-associated lymphoid tissue (MALT) lymphoma. Among the 57 patients with gastric DLBCL, 20 patients (35.1%) were classified as the germinal center B cell-like (GCB) subtype and 37 patients (64.9%) as the non-GCB subtype. The 83 patients had a five-year overall survival (OS) and event-free survival (EFS) of 52% and 59%, respectively. Cox regression analysis showed that stage-modified international prognostic index (IPI) and performance status (PS) were independent predictors of survival. In the 67 B-cell lymphoma patients who received chemotherapy, 36 patients treated with rituximab (at least 3 cycles) had a mean OS of 72 months (95% CI 62-81) versus 62 months (95% CI 47-76) for patients without rituximab treatment (P = 0.021). Conclusion The proportion of Chinese gastric DLBCL cases with non-GCB subtype was higher than the GCB subtype. Stage-modified IPI and PS were effective prognostic factors in Chinese patients with PGL. Our data suggested that primary gastric B-cell lymphoma might have an improved outcome with rituximab in addition to chemotherapy. More studies are necessary, preferentially large prospective randomized clinical trials to obtain more information on the impact of the rituximab in the primary gastric B-cell lymphoma. PMID:20604963

2010-01-01

16

Classical Chinese Landscape Painting and the Aesthetic Appreciation of Nature  

ERIC Educational Resources Information Center

Recent theories of the aesthetic appreciation of nature or natural environments have done much to clarify what might be essential to such appreciation. Such accounts are incomplete, however, as they depend on a strict separation between works of art and nature itself. This paper shows how classical Chinese landscape painting offers a way to…

Turner, Matthew

2009-01-01

17

Long Ago and Far Away: On the Use of Classical Chinese Poetry in Poetry Therapy.  

ERIC Educational Resources Information Center

Examines four characteristics (brevity, straightforward diction, contemplative mood, and autobiographical content) of classical Chinese poetry, to show how classical Chinese poetry is appropriate for use in many poetry therapy contexts. Includes an 8-item annotated list of sources. (SR)

Rossiter, Charles

2001-01-01

18

FOXO1 repression contributes to block of plasma cell differentiation in classical Hodgkin lymphoma.  

PubMed

The survival of classical Hodgkin lymphoma (cHL) cells depends on activation of NF-?B, JAK/STAT, and IRF4. Whereas these factors typically induce the master regulator of plasma cell (PC) differentiation PRDM1/BLIMP-1, levels of PRDM1 remain low in cHL. FOXO1, playing a critical role in normal B-cell development, acts as a tumor suppressor in cHL, but has never been associated with induction of PC differentiation. Here we show that FOXO1 directly upregulates the full-length isoform PRDM1? in cHL cell lines. We also observed a positive correlation between FOXO1 and PRDM1 expression levels in primary Hodgkin-Reed-Sternberg cells. Further, we show that PRDM1? acts as a tumor suppressor in cHL at least partially by blocking MYC. Here we provide a link between FOXO1 repression and PRDM1? downregulation in cHL and identify PRDM1? as a tumor suppressor in cHL. The data support a potential role for FOXO transcription factors in normal PC differentiation. PMID:25232062

Vogel, Marion J; Xie, Linka; Guan, Hanfeng; Tooze, Reuben M; Maier, Thomas; Kostezka, Ulrike; Maier, Harald J; Holzmann, Karlheinz; Chan, Fong Chun; Steidl, Christian; Reichel, Jonathan B; Weitzer, Clarissa D; Gehringer, Franziska; Kick, Anita B; Cesarman, Ethel; Roshal, Mikhail; Gascoyne, Randy D; Möller, Peter; Wirth, Thomas; Ushmorov, Alexey

2014-11-13

19

On untranslatability of classical Chinese poetry: From the perspective of aesthetic function of language  

Microsoft Academic Search

The author analyzes the untranslatability of the classical Chinese poetry from the perspective of aesthetic function of language. The untranslatability lies firstly in the heterogeneity, indeterminism and the ambiguity of the Chinese language itself. Moreover, the classical Chinese poetry displays its unique features and beauty which can not be rendered into English in terms of aesthetic function of language.

LIANG Zhi-min

20

A study of quantum mechanical probabilities in the classical Hodgkin-Huxley model.  

PubMed

The Hodgkin-Huxley (HH) model is a powerful model to explain different aspects of spike generation in excitable cells. However, the HH model was proposed in 1952 when the real structure of the ion channel was unknown. It is now common knowledge that in many ion-channel proteins the flow of ions through the pore is governed by a gate, comprising a so-called "selectivity filter" inside the ion channel, which can be controlled by electrical interactions. The selectivity filter (SF) is believed to be responsible for the selection and fast conduction of particular ions across the membrane of an excitable cell. Other (generally larger) parts of the molecule such as the pore-domain gate control the access of ions to the channel protein. In fact, two types of gates are considered here for ion channels: the "external gate", which is the voltage sensitive gate, and the "internal gate" which is the selectivity filter gate (SFG). Some quantum effects are expected in the SFG due to its small dimensions, which may play an important role in the operation of an ion channel. Here, we examine parameters in a generalized model of HH to see whether any parameter affects the spike generation. Our results indicate that the previously suggested semi-quantum-classical equation proposed by Bernroider and Summhammer (BS) agrees strongly with the HH equation under different conditions and may even provide a better explanation in some cases. We conclude that the BS model can refine the classical HH model substantially. PMID:25483232

Moradi, N; Scholkmann, F; Salari, V

2014-12-01

21

Hodgkin-Reed-Sternberg Cells in Classical Hodgkin Lymphoma Show Alterations of Genes Encoding the NADPH Oxidase Complex and Impaired Reactive Oxygen Species Synthesis Capacity  

PubMed Central

The membrane bound NADPH oxidase involved in the synthesis of reactive oxygen species (ROS) is a multi-protein enzyme encoded by CYBA, CYBB, NCF1, NCF2 and NCF4 genes. Growing evidence suggests a role of ROS in the modulation of signaling pathways of non-phagocytic cells, including differentiation and proliferation of B-cell progenitors. Transcriptional downregulation of the CYBB gene has been previously reported in cell lines of the B-cell derived classical Hodgkin lymphoma (cHL). Thus, we explored functional consequences of CYBB downregulation on the NADPH complex. Using flow cytometry to detect and quantify superoxide anion synthesis in cHL cell lines we identified recurrent loss of superoxide anion production in all stimulated cHL cell lines in contrast to stimulated non-Hodgkin lymphoma cell lines. As CYBB loss proved to exert a deleterious effect on the NADPH oxidase complex in cHL cell lines, we analyzed the CYBB locus in Hodgkin and Reed-Sternberg (HRS) cells of primary cHL biopsies by in situ hybridisation and identified recurrent deletions of the gene in 8/18 cases. Immunohistochemical analysis to 14 of these cases revealed a complete lack of detectable CYBB protein expression in all HRS cells in all cases studied. Moreover, by microarray profiling of cHL cell lines we identified additional alterations of NADPH oxidase genes including CYBA copy number loss in 3/7 cell lines and a significant downregulation of the NCF1 transcription (p=0.006) compared to normal B-cell subsets. Besides, NCF1 protein was significantly downregulated (p<0.005) in cHL compared to other lymphoma cell lines. Together this findings show recurrent alterations of the NADPH oxidase encoding genes that result in functional inactivation of the enzyme and reduced production of superoxide anion in cHL. PMID:24376854

Sosna, Justyna; Döring, Claudia; Klapper, Wolfram; Küppers, Ralf; Böttcher, Sebastian; Adam, Dieter; Siebert, Reiner; Schütze, Stefan

2013-01-01

22

Hodgkin-Reed-Sternberg cells in classical Hodgkin lymphoma show alterations of genes encoding the NADPH oxidase complex and impaired reactive oxygen species synthesis capacity.  

PubMed

The membrane bound NADPH oxidase involved in the synthesis of reactive oxygen species (ROS) is a multi-protein enzyme encoded by CYBA, CYBB, NCF1, NCF2 and NCF4 genes. Growing evidence suggests a role of ROS in the modulation of signaling pathways of non-phagocytic cells, including differentiation and proliferation of B-cell progenitors. Transcriptional downregulation of the CYBB gene has been previously reported in cell lines of the B-cell derived classical Hodgkin lymphoma (cHL). Thus, we explored functional consequences of CYBB downregulation on the NADPH complex. Using flow cytometry to detect and quantify superoxide anion synthesis in cHL cell lines we identified recurrent loss of superoxide anion production in all stimulated cHL cell lines in contrast to stimulated non-Hodgkin lymphoma cell lines. As CYBB loss proved to exert a deleterious effect on the NADPH oxidase complex in cHL cell lines, we analyzed the CYBB locus in Hodgkin and Reed-Sternberg (HRS) cells of primary cHL biopsies by in situ hybridisation and identified recurrent deletions of the gene in 8/18 cases. Immunohistochemical analysis to 14 of these cases revealed a complete lack of detectable CYBB protein expression in all HRS cells in all cases studied. Moreover, by microarray profiling of cHL cell lines we identified additional alterations of NADPH oxidase genes including CYBA copy number loss in 3/7 cell lines and a significant downregulation of the NCF1 transcription (p=0.006) compared to normal B-cell subsets. Besides, NCF1 protein was significantly downregulated (p<0.005) in cHL compared to other lymphoma cell lines. Together this findings show recurrent alterations of the NADPH oxidase encoding genes that result in functional inactivation of the enzyme and reduced production of superoxide anion in cHL. PMID:24376854

Giefing, Maciej; Winoto-Morbach, Supandi; Sosna, Justyna; Döring, Claudia; Klapper, Wolfram; Küppers, Ralf; Böttcher, Sebastian; Adam, Dieter; Siebert, Reiner; Schütze, Stefan

2013-01-01

23

Macrophages and Dendritic Cells as Actors in the Immune Reaction of Classical Hodgkin Lymphoma  

PubMed Central

Background The inflammatory infiltrate plays a pivotal role in classical Hodgkin lymphoma (cHL). Here, we focussed on the role of macrophages (M?) and dendritic cells (DC). Methods M? and DC infiltration was investigated in 106 cHL specimens using immunohistochemistry and cytokine expression was analyzed in a subset by real-time PCR. Human peripheral blood-derived monocytes, DC, M? stimulated with GM-CSF (M?GM-CSF, pro-inflammatory M?-1-model) or M-CSF (M?M-CSF, immunomodulatory M?-2-model) were incubated with cHL cell line (L1236, HDLM2) supernatants (SN). DC maturation or M? polarization were investigated by flow cytometry. Furthermore, the impact of DC or M? on cHL cell proliferation was analyzed by BrdU/CFSE assay. Results In cHL tissues mature myeloid (m)DC and M? predominated. High numbers of CD83+ mDC and low numbers of CD163+ M? were associated with improved disease specific survival. In numerous cHL specimens increased levels of both pro- and anti-inflammatory cytokines and of IL13 and GM-CSF were observed compared to reactive lymphadenopathies. Maturation of DC and induction and maintenance of an immunomodulatory M? phenotype were promoted by SN derived from cHL cell lines. TNF? neutralization in SN resulted in a significant inhibition of mDC maturation. DC and pro-inflammatory M? inhibited the proliferation of cHL cells. Conclusion Adopting an immunomodulatory phenotype is a potential mechanism for how M? promote immune evasion in cHL. Mature DC, in contrast, might participate in antitumoral immunity. PMID:25470820

Tudor, Christiane Silke; Bruns, Heiko; Daniel, Christoph; Distel, Luitpold Valentin; Hartmann, Arndt; Gerbitz, Armin; Buettner, Maike Julia

2014-01-01

24

Insulin-Like Growth Factor 1 Receptor Is a Prognostic Factor in Classical Hodgkin Lymphoma  

PubMed Central

The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p?=?.029 and PFS 77%, p?=?.047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines. PMID:24489919

Liang, Zheng; Diepstra, Arjan; Xu, Chuanhui; van Imhoff, Gustaaf; Plattel, Wouter; Van Den Berg, Anke; Visser, Lydia

2014-01-01

25

Refractory Classical Hodgkin Lymphoma Presenting with Atypical Cutaneous Involvement and Diagnosis of ZZ Phenotype Alpha-1 Antitrypsin Deficiency  

PubMed Central

Cutaneous Hodgkin lymphoma is a rare condition. Specific neoplastic involvement can be primary (confined to the skin) or secondary to systemic involvement (metastatic). Cutaneous involvement by HL usually occurs late in the course and is associated with poor prognosis; however in some cases it can exhibit indolent behavior. Skin involvement with nonspecific cutaneous findings may represent a paraneoplastic syndrome. We describe a case of 46-year-old white male patient presented with rash and lymphadenopathy which led to the diagnosis of stage IVE mixed cellularity classical Hodgkin lymphoma with skin involvement. His disease was refractory to multiple lines of chemotherapy including (1) AVD (doxorubicin/bleomycin/dacarbazine), (2) brentuximab, and (3) bendamustine, he later achieved complete remission with (4) GCD (gemcitabine/carboplatin/dexamethasone) salvage regimen. Bleomycin was not given secondary to poor pulmonary function tests. His treatment was complicated after AVD with multiple pneumothoraces which unmasked the diagnosis of ZZ phenotype alpha-1 antitrypsin (ATT) deficiency. Simultaneous existence of Hodgkin lymphoma and ATT is rarely reported. PMID:24955265

Kraus, Teresa; Cherry, Mohamad

2014-01-01

26

How Is Hodgkin Disease Diagnosed?  

MedlinePLUS

... found in classic Hodgkin disease. Tests for other proteins may point to nodular lymphocyte predominant Hodgkin disease, to non-Hodgkin lymphoma rather than Hodgkin disease, or to other diseases entirely. Last Medical Review: 07/10/2014 Last Revised: 01/13/2015 Back to top »

27

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma  

PubMed Central

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific accessible chromatin by global mapping of DNaseI hypersensitive sites and analyzed enriched TF-binding motifs in these regions. Applying this unbiased approach to classical Hodgkin lymphoma (HL), a common B-cell–derived lymphoma with a complex pattern of deregulated TFs, we discovered interferon regulatory factor (IRF) sites among the top enriched motifs. High-level expression of the proinflammatory TF IRF5 was specific to HL cells and crucial for their survival. Furthermore, IRF5 initiated a regulatory cascade in human non-Hodgkin B-cell lines and primary murine B cells by inducing the TF AP-1 and cooperating with NF-?B to activate essential characteristic features of HL. Our strategy efficiently identified a lymphoma type-specific key regulator and uncovered a tumor promoting role of IRF5. PMID:25288773

Kreher, Stephan; Bouhlel, M. Amine; Cauchy, Pierre; Lamprecht, Björn; Li, Shuang; Grau, Michael; Hummel, Franziska; Köchert, Karl; Anagnostopoulos, Ioannis; Jöhrens, Korinna; Hummel, Michael; Hiscott, John; Wenzel, Sören-Sebastian; Lenz, Peter; Schneider, Markus; Küppers, Ralf; Scheidereit, Claus; Giefing, Maciej; Siebert, Reiner; Rajewsky, Klaus; Lenz, Georg; Cockerill, Peter N.; Janz, Martin; Dörken, Bernd; Bonifer, Constanze; Mathas, Stephan

2014-01-01

28

Relationship of intratumoural protein expression patterns to age and Epstein-Barr virus status in classical Hodgkin lymphoma.  

PubMed

In Western countries, the age distribution of Hodgkin lymphoma (HL) follows a characteristic bimodal curve showing an early and a late peak at approximately 35 and 70 yr, respectively. Furthermore, the presence of latent Epstein-Barr virus (EBV) genome in the Hodgkin Reed-Sternberg cells, the tumour cell population of classical HL (cHL), has been found to have adverse prognostic impact in elderly, but not in younger cHL patients. We have characterised the protein expression in tumour tissue samples from younger (?55 yr) and elderly (>55 yr) cHL patients and correlated the findings with EBV status. Differentially expressed proteins according to patients' age as well as tumoural EBV status belonged to different biological functional domains, such as apoptosis, cytoskeletal organisation, response to oxygen levels and regulation of catabolic/metabolic processes. The differential expression of selected proteins, cytosolic aminopeptidase, heterogeneous nuclear ribonucleoprotein K, serotransferrin and alpha-1-antitrypsin was further validated by Western blot analysis. Discovery-based proteomics characterising biological features distinctive for subsets of cHL patients may be useful for the identification of novel biomarkers with potential therapeutic relevance. An evaluation of the prognostic impact of protein expression pattern in general and individually expressed proteins in particular is warranted. PMID:25307790

Ludvigsen, Maja; Kamper, Peter; Hamilton-Dutroit, Stephen J; Bendix, Knud; Møller, Michael B; d'Amore, Francesco A; Honoré, Bent

2014-10-11

29

Why Chinese People Play Western Classical Music: Transcultural Roots of Music Philosophy  

ERIC Educational Resources Information Center

This paper addresses the complex relationship between Confucian values and music education in East Asia, particularly its history in China. How does one account for the present "cultural fever" of Western classical music that has infected more than 100 million Chinese practitioners? It is proposed that Western classical music finds transcultural…

Huang, Hao

2012-01-01

30

A Cognitive Stylistic Analysis of Classical Chinese Poetry Translation  

Microsoft Academic Search

This paper adopts the theoretical notion of construal elaborated in Langacker's Foundations of Cognitive Grammar, and conducts a fresh analysis of Chinese poetry translation in terms of construal operations. The paper discusses how different aspects of translation are related to construal: different translation choices, shifts and variations are live manifestations of the dynamic construal operations on the one hand, and

Tan Yesheng

2008-01-01

31

A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin  

PubMed Central

At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials, the response rate and complete remission rate of this drug were 73% and 40%, respectively, for relapsed and refractory HL. Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab. Before the treatment with brentuximab, the patient underwent chemotherapy, radiotherapy, and autologous stem cell transplantation. However, the disease continued to progress, affecting multiple organs and prompting symptoms such as persistent fever. After the treatment with brentuximab, the patient's condition improved. Body temperature returned to normal after 4 days. Lung nodules were reduced in size and number after a single course of treatment, and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment, respectively. The entire treatment process progressed smoothly, though the patient experienced some symptoms due to chemotherapy, including peripheral neuritis of the limbs, irritating dry cough, and mild increase in aminotransferase. No serious adverse effects were observed. The current general condition of the patient is good; the continuous complete remission has amounted to 6 months. PMID:23544448

Cao, Zhi-Gang; Zhou, Hong-Wei; Peng, Chao-Jin; Liu, Mo; Du, Yu; Yang, Qing-Ming

2013-01-01

32

A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin.  

PubMed

At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials, the response rate and complete remission rate of this drug were 73% and 40%, respectively, for relapsed and refractory HL. Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab. Before the treatment with brentuximab, the patient underwent chemotherapy, radiotherapy, and autologous stem cell transplantation. However, the disease continued to progress, affecting multiple organs and prompting symptoms such as persistent fever. After the treatment with brentuximab, the patient's condition improved. Body temperature returned to normal after 4 days. Lung nodules were reduced in size and number after a single course of treatment, and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment, respectively. The entire treatment process progressed smoothly, though the patient experienced some symptoms due to chemotherapy, including peripheral neuritis of the limbs, irritating dry cough, and mild increase in aminotransferase. No serious adverse effects were observed. The current general condition of the patient is good; the continuous complete remission has amounted to 6 months. PMID:23544448

Cao, Zhi-Gang; Zhou, Hong-Wei; Peng, Chao-Jin; Liu, Mo; Du, Yu; Yang, Qing-Ming

2013-09-01

33

Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial  

PubMed Central

Increased tumor-associated macrophages (TAMs) are reported to be associated with poor prognosis in classic Hodgkin lymphoma (CHL). We investigated the prognostic significance of TAMs in the E2496 Intergroup trial, a multicenter phase 3 randomized controlled trial comparing ABVD and Stanford V chemotherapy in locally extensive and advanced stage CHL. Tissue microarrays were constructed from formalin-fixed, paraffin-embedded tumor tissue and included 287 patients. Patients were randomly assigned into training (n = 143) and validation (n = 144) cohorts. Immunohistochemistry for CD68 and CD163, and in situ hybridization for EBV-encoded RNA were performed. CD68 and CD163 IHC were analyzed by computer image analysis; optimum thresholds for overall survival (OS) were determined in the training cohort and tested in the independent validation cohort. Increased CD68 and CD163 expression was significantly associated with inferior failure-free survival and OS in the validation cohort. Increased CD68 and CD163 expression was associated with increased age, EBV-encoded RNA positivity, and mixed cellularity subtype of CHL. Multivariate analysis in the validation cohort showed increased CD68 or CD163 expression to be significant independent predictors of inferior failure-free survival and OS. We demonstrate the prognostic significance of TAMs in locally extensive and advanced-stage CHL in a multicenter phase 3 randomized controlled clinical trial. PMID:22948049

Tan, King L.; Scott, David W.; Hong, Fangxin; Kahl, Brad S.; Fisher, Richard I.; Bartlett, Nancy L.; Advani, Ranjana H.; Buckstein, Rena; Rimsza, Lisa M.; Connors, Joseph M.; Steidl, Christian; Gordon, Leo I.; Horning, Sandra J.

2012-01-01

34

Peripheral blood absolute lymphocyte/monocyte ratio recovery during ABVD treatment cycles predicts clinical outcomes in classical Hodgkin lymphoma.  

PubMed

The peripheral blood absolute lymphocyte/monocyte count ratio at diagnosis (ALC/AMC-DX) predicts survival in classical Hodgkin lymphoma (cHL). However, a limitation of the ALC/AMC-DX is the inability to assess sequentially the host/tumor interaction during treatment. Therefore, we retrospectively examined the ALC/AMC ratio, as a surrogate marker of host immunity (ALC) and tumor microenvironment (AMC), at each adriamycin, bleomycin, vinblastine and dacarbazine treatment cycle as a predictor for clinical outcomes. From 1990 until 2008, 190 cHL patients were diagnosed, treated and followed at Mayo Clinic Rochester and qualified for the study. The ALC/AMC ratio at each treatment cycle was a predictor for overall survival (OS) and progression-free survival (PFS). An ALC/AMC ratio ?1.1 versus ALC/AMC <1.1 during treatment cycles was an independent predictor for OS (hazard ratio (HR)=0.14; 95% confidence interval (CI): 0.04-0.40; P<0.0002) and for PFS (HR=0.19; 95% CI: 0.05-0.82; P<0.03). The ALC/AMC ratio during treatment cycles is a predictor for survival and provides a platform to develop therapeutic modalities to manipulate the ALC/AMC ratio during chemotherapy to improve clinical outcomes in cHL. PMID:23599022

Porrata, L F; Ristow, K M; Habermann, T M; Macon, W R; Witzig, T E; Colgan, J P; Inwards, D J; Ansell, S M; Micallef, I N; Johnston, P B; Nowakowski, G; Thompson, C A; Markovic, S N

2013-01-01

35

Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"  

ERIC Educational Resources Information Center

This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it is impossible and undesirable…

Tan, Sor-Hoon

2011-01-01

36

Analysis of biological and technical variability in gene expression assays from formalin-fixed paraffin-embedded classical Hodgkin lymphomas.  

PubMed

Formalin-fixed paraffin-embedded (FFPE) tissues are invaluable sources of biological material for research and diagnostic purposes. In this study, we aimed to identify biological and technical variability in RT-qPCR TaqMan® assays performed with FFPE-RNA from lymph nodes of classical Hodgkin lymphoma samples. An ANOVA-nested 6-level design was employed to evaluate BCL2, CASP3, IRF4, LYZ and STAT1 gene expression. The most variable genes were CASP3 (low expression) and LYZ (high expression). Total variability decreased after normalization for all genes, except by LYZ. Genes with moderate and low expression were identified and suffered more the effects of the technical manipulation than high-expression genes. Pre-amplification was shown to introduce significant technical variability, which was partially alleviated by lowering to a half the amount of input RNA. Ct and Cy0 quantification methods, based on cycle-threshold and the kinetic of amplification curves, respectively, were compared. Cy0 method resulted in higher quantification values, leading to the decrease of total variability in CASP3 and LYZ genes. The mean individual noise was 0.45 (0.31 to 0.61 SD), indicating a variation of gene expression over ~1.5 folds from one case to another. We showed that total variability in RT-qPCR from FFPE-RNA is not higher than that reported for fresh complex tissues, and identified gene-, and expression level-sources of biological and technical variability, which can allow better strategies for designing RT-qPCR assays from highly degraded and inhibited samples. PMID:25236575

Vera-Lozada, Gabriela; Scholl, Vanesa; Barros, Mário Henrique M; Sisti, Davide; Guescini, Michele; Stocchi, Vilberto; Stefanoff, Claudio Gustavo; Hassan, Rocio

2014-12-01

37

Classical Hodgkin’s lymphoma in adults: guidelines of the Italian Society of Hematology, the Italian Society of Experimental Hematology, and the Italian Group for Bone Marrow Transplantation on initial work-up, management, and follow-up  

PubMed Central

The Italian Society of Hematology (SIE), the Italian Society of Experimental Haematology (SIES) and the Italian Group for Bone Marrow Transplantation (GITMO) commissioned a project to develop practice guidelines for the initial work-up, therapy and follow-up of classical Hodgkin’s lymphoma. Key questions to the clinical evaluation and treatment of this disease were formulated by an Advisory Committee, discussed and approved by an Expert Panel (EP) composed of senior hematologists and one radiotherapist. After a comprehensive and systematic literature review, the EP recommendations were graded according to their supporting evidence. An explicit approach to consensus methodologies was used for evidence interpretation and for producing recommendations in the absence of a strong evidence. The EP decided that the target domain of the guidelines should include only classical Hodgkin’s lymphoma, as defined by the WHO classification, and exclude lymphocyte predominant histology. Distinct recommendations were produced for initial work-up, first-line therapy of early and advanced stage disease, monitoring procedures and salvage therapy, including hemopoietic stem cell transplant. Separate recommendations were formulated for elderly patients. Pre-treatment volumetric CT scan of the neck, thorax, abdomen, and pelvis is mandatory, while FDG-PET is recommended. As to the therapy of early stage disease, a combined modality approach is still recommended with ABVD followed by involved-field radiotherapy; the number of courses of ABVD will depend on the patient risk category (favorable or unfavorable). Full-term chemotherapy with ABVD is recommended in advanced stage disease; adjuvant radiotherapy in patients without initial bulk who achieved a complete remission is not recommended. In the elderly, chemotherapy regimens more intensive than ABVD are not recommended. Early evaluation of response with FDG-PET scan is suggested. Relapsed or refractory patients should receive high-dose chemotherapy and autologous hemopoietic stem cells transplant. Allogeneic transplant is recommended in patients relapsing after autologous transplant. All fertile patients should be informed of the possible effects of therapy on gonadal function and fertility preservation measures should be taken before the initiation of therapy. PMID:19278966

Brusamolino, Ercole; Bacigalupo, Andrea; Barosi, Giovanni; Biti, Giampaolo; Gobbi, Paolo G.; Levis, Alessandro; Marchetti, Monia; Santoro, Armando; Zinzani, Pier Luigi; Tura, Sante

2009-01-01

38

Genome-Wide Association Study of Classical Hodgkin Lymphoma and Epstein–Barr Virus Status–Defined Subgroups  

PubMed Central

Background Accumulating evidence suggests that risk factors for classical Hodgkin lymphoma (cHL) differ by tumor Epstein–Barr virus (EBV) status. This potential etiological heterogeneity is not recognized in current disease classification. Methods We conducted a genome-wide association study of 1200 cHL patients and 6417 control subjects, with validation in an independent replication series, to identify common genetic variants associated with total cHL and subtypes defined by tumor EBV status. Multiple logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals (CIs) assuming a log-additive genetic model for the variants. All statistical tests were two-sided. Results Two novel loci associated with total cHL irrespective of EBV status were identified in the major histocompatibility complex region; one resides adjacent to MICB (rs2248462: OR = 0.61, 95% CI = 0.53 to 0.69, P = 1.3 × 10?13) and the other at HLA-DRA (rs2395185: OR = 0.56, 95% CI = 0.50 to 0.62, P = 8.3 × 10?25) with both results confirmed in an independent replication series. Consistent with previous reports, associations were found between EBV-positive cHL and genetic variants within the class I region (rs2734986, HLA-A: OR = 2.45, 95% CI = 2.00 to 3.00, P = 1.2 × 10?15; rs6904029, HCG9: OR = 0.46, 95% CI = 0.36 to 0.59, P = 5.5 × 10?10) and between EBV-negative cHL and rs6903608 within the class II region (rs6903608, HLA-DRA: OR = 2.08, 95% CI = 1.84 to 2.35, P = 6.1 × 10?31). The association between rs6903608 and EBV-negative cHL was confined to the nodular sclerosis histological subtype. Evidence for an association between EBV-negative cHL and rs20541 (5q31, IL13: OR = 1.53, 95% CI = 1.32 to 1.76, P = 5.4 x 10?9), a variant previously linked to psoriasis and asthma, was observed; however, the evidence for replication was less clear. Notably, one additional psoriasis-associated variant, rs27524 (5q15, ERAP1), showed evidence of an association with cHL in the genome-wide association study (OR = 1.21, 95% CI = 1.10 to 1.33, P = 1.5 × 10?4) and replication series (P = .03). Conclusion Overall, these results provide strong evidence that EBV status is an etiologically important classification of cHL and also suggest that some components of the pathological process are common to both EBV-positive and EBV-negative patients. PMID:22286212

Urayama, Kevin Y.; Jarrett, Ruth F.; Hjalgrim, Henrik; Diepstra, Arjan; Kamatani, Yoichiro; Chabrier, Amelie; Gaborieau, Valerie; Boland, Anne; Nieters, Alexandra; Becker, Nikolaus; Foretova, Lenka; Benavente, Yolanda; Maynadié, Marc; Staines, Anthony; Shield, Lesley; Lake, Annette; Montgomery, Dorothy; Taylor, Malcolm; Smedby, Karin Ekström; Amini, Rose-Marie; Adami, Hans-Olov; Glimelius, Bengt; Feenstra, Bjarke; Nolte, Ilja M.; Visser, Lydia; van Imhoff, Gustaaf W.; Lightfoot, Tracy; Cocco, Pierluigi; Kiemeney, Lambertus; Vermeulen, Sita H.; Holcatova, Ivana; Vatten, Lars; Macfarlane, Gary J.; Thomson, Peter; Conway, David I.; Benhamou, Simone; Agudo, Antonio; Healy, Claire M.; Overvad, Kim; Tjønneland, Anne; Melin, Beatrice; Canzian, Federico; Khaw, Kay-Tee; Travis, Ruth C.; Peeters, Petra H. M.; González, Carlos A.; Quirós, José Ramón; Sánchez, María-José; Huerta, José María; Ardanaz, Eva; Dorronsoro, Miren; Clavel-Chapelon, Françoise; Bueno-de-Mesquita, H. Bas; Riboli, Elio; Roman, Eve; Boffetta, Paolo; de Sanjosé, Silvia; Zelenika, Diana; Melbye, Mads; van den Berg, Anke; Lathrop, Mark; McKay, James D.

2012-01-01

39

Epstein-Barr virus infection is inversely correlated with the expression of retinoblastoma protein in Reed-Sternberg cells in classic Hodgkin lymphoma  

PubMed Central

Classic Hodgkin lymphoma (cHL) is characterized by few neoplastic Hodgkin/Reed-Sternberg (H/RS) cells in a background of intense inflammatory infiltrate. Epstein-Barr virus (EBV) has been shown to affect cell cycle and regulation of apoptosis. In total, 82 cases of cHL were studied. Five- micrometer sections were prepared and stained with haematoxylin and eosin and immunohistochemical streptavidin-biotin methods for EBV-LMP-1, pRb, ki-67 and cleaved caspase-3. In-situ hybridization for EBV encoded RNA was used to confirm the detection of EBV in H/RS cells. There were 45 nodular sclerosis, 28 mixed cellularity, 4 lymphocyte-rich, and 5 lymphocyte depletion subtypes in this series of cases. EBV and pRb were detected in 55% (46/82) and 64% (50/82) of the cases respectively. EBV was detected in 78% (25/32) of pRb-negative cases and 81% (29/36) of EBV-negative cases are pRb-positive. A statistically significant inverse relationship was observed between the presence of EBV and expression of pRb (P = 0.001). In conclusion, EBV infection is inversely correlated with pRb in H/RS cells in cHL.

Al-Salam, Suhail; Awwad, Aktham; Alashari, Mouied

2014-01-01

40

The NF-?B inhibitor DHMEQ decreases survival factors, overcomes the protective activity of microenvironment and synergizes with chemotherapy agents in classical Hodgkin lymphoma.  

PubMed

The NF-?B inhibitor DHMEQ has shown preclinical activity in classical Hodgkin Lymphoma (cHL). Here we evaluated if DHMEQ could affect microenvironmental interactions and formation and improve the activity of drugs used in relapsed/refractory cHL. We demonstrated that DHMEQ down-regulated the NF-?B target genes IRF4 and CD40, the secretion of IL-6, CCL5, CCL17 and generated ROS. Cytotoxicity, CD30 down-modulation and CD30 shedding by DHMEQ were prevented by ROS scavenger NAC. DHMEQ overcame stimuli from CD40 engagement and fibroblasts and enhanced doxorubicin, cisplatin and gemcitabine activity. Our results suggest that DHMEQ may be a promising agent for future therapeutic strategies in cHL. PMID:24704296

Celegato, Marta; Borghese, Cinzia; Umezawa, Kazuo; Casagrande, Naike; Colombatti, Alfonso; Carbone, Antonino; Aldinucci, Donatella

2014-07-10

41

[Hodgkin lymphoma].  

PubMed

ABVD regimen has been established as a standard therapy for Hodgkin lymphoma, and over 70% of patients with Hodgkin lymphoma would be curable. But some refractory diseases still exist. Recent developments of molecular target agents have been expecting to improve the clinical outcomes of Hodgkin lymphoma. Anti CD30 antibody-drug conjugate, brentuximab vedotin, is a promising drug for relapsed and refractory Hodgkin lymphoma, and is also explored to be incorporated into first line therapy. Small molecules such as HDACIs and mTOR inhibitors have been proved as active agents for relapsed diseases. Standard care of Hodgkin lymphoma could be changed in next decade by these molecular targeting agents. PMID:25016811

Nagai, Hirokazu

2014-06-01

42

Hodgkin Lymphoma in Adults (Beyond the Basics)  

MedlinePLUS

... Radiation therapy — Radiation therapy (RT) involves using high-energy X-rays to stop the growth of cancer ... more Related articles Patient information: Bone ... adults Epidemiology, pathologic features, and diagnosis of classical Hodgkin ...

43

Classical risk factors of cardiovascular disease among Chinese male steel workers: a prospective cohort study for 20 years  

PubMed Central

Background Cardiovascular disease (CVD) constitutes a major public health problem in China and worldwide. We aimed to examine classical risk factors and their magnitudes for CVD in a Chinese cohort with over 20 years follow-up. Methods A cohort of 5092 male steelworkers recruited from 1974 to 1980 in Beijing of China was followed up for an average of 20.84 years. Cox proportional-hazards regression model were used to evaluate the risk of developing a first CVD event in the study participants who were free of CVD at the baseline. Results The multivariable-adjusted hazard ratio (HR) associated with every 20 mmHg rise in systolic blood pressure (SBP) was 1.63 in this Chinese male population, which was higher than in Caucasians. Compared to non-smokers, men who smoked not less than one-pack-a-day had a HR of 2.43 (95% confidence interval [CI], 1.75-3.38). The HR (95% CI) for every 20 mg/dl increase in total serum cholesterol (TC) and for every point rise in body mass index (BMI) was 1.13 (1.04-1.23) and 1.06 (1.02-1.09), respectively. Conclusions Our study documents that hypertension, smoking, overweight and hypercholesterolemia are major conventional risk factors of CVD in Chinese male adults. Continued strengthening programs for prevention and intervention on these risk factors are needed to reduce the incidence of CVD in China. PMID:21702967

2011-01-01

44

Non-Hodgkin lymphoma  

MedlinePLUS

Lymphoma - non-Hodgkin; Lymphocytic lymphoma; Histiocytic lymphoma; Lymphoblastic lymphoma; Cancer - non-Hodgkin lymphoma ... National Cancer Institute: PDQ Adult Non-Hodgkin Lymphoma ... Feb. 28, 2014. Available at http://www.cancer.gov/cancertopics/ ...

45

Jonathan Hodgkin.  

PubMed

Jonathan Hodgkin graduated from Oxford in 1971 and then did a PhD with Sydney Brenner at MRC LMB in Cambridge, studying behavioural genetics in the nematode Caenorhabditis elegans. Later, after a couple of years working with myxobacteria as a postdoc in Dale Kaiser's lab at Stanford, he returned to LMB as a staff member, where he remained for most of the subsequent two decades. In the year 2000, he moved to Oxford as Professor of Genetics in the Department of Biochemistry, switching his major research interests from developmental genetics and sex determination to the study of host-pathogen interactions in the worm. For the past ten years, he has acted as curator of the C. elegans genetic map and gene nomenclature, and he is currently President of the Genetics Society of Great Britain. PMID:15062112

Hodgkin, Jonathan

2004-04-01

46

Chinese Mathematics  

NSDL National Science Digital Library

The School of Mathematics and Statistics at the University of St. Andrews Scotland offers this website on the history of Chinese Mathematics. Key features highlighted in the overview include: a discussion of the Chinese version of Pythagoras's theorem, a famous Chinese mathematics book commonly known as the Nine Chapters on the Mathematical Art, and the work of several Chinese mathematicians. Visitors to the website can also browse a chronological listing of several Chinese mathematicians and read about their careers. Other features of the website include a section summarizing each chapter from the Nine Chapters on the Mathematical Art, a section highlighting ten other mathematical classics, a review of the Chinese numeral system, and a collection of Chinese problems, which are extracted from various articles in their archive.

47

CD68-positive tumor-associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assessment.  

PubMed

Finding new prognostic factors to identify patients with Hodgkin lymphoma (HL) at risk of treatment resistance or relapse remains challenging in daily practice. We evaluated the relationship between CD68 expression, interim positron emission tomography (iPET) results and outcome in 158 patients with HL diagnosed from February 1995 to July 2011. Immunohistochemistry (anti-CD68) gave two groups: low with ? 25% positive cells (121 patients) and high with > 25% (37 patients). Five-year overall survival was higher in the low group (88.4% vs. 63.2%, p = 0.0151), as was progression-free survival (74.5% vs. 40.7%, p = 0.0003). In 68 patients evaluable, iPET correlated with CD68: 13/52 patients (25%) in the low group had positive iPET as compared to 11/16 patients (68%) in the high group (p = 0.0016). This study confirms the prognostic value of CD68 in HL. We found a correlation between CD68 and iPET suggesting potential for a better stratification. PMID:24766492

Touati, Mohamed; Delage-Corre, Manuela; Monteil, Jacques; Abraham, Julie; Moreau, Stéphane; Remenieras, Liliane; Gourin, Marie-Pierre; Dmytruk, Nataliya; Olivrie, Agnès; Turlure, Pascal; Girault, Stéphane; Labrousse, François; Preux, Pierre-Marie; Jaccard, Arnaud; Bordessoule, Dominique

2014-06-27

48

Focusing on the Classical or Contemporary? Chinese Science Teacher Educators' Conceptions of Nature of Science Content to Be Taught to Pre-service Science Teachers  

NASA Astrophysics Data System (ADS)

Drawing from the phenomenographic perspective, an exploratory study investigated Chinese teacher educators' conceptions of teaching Nature of Science (NOS) to pre-service science teachers through semi-structured interviews. Five key dimensions emerged from the data. This paper focuses on the dimension, NOS content to be taught to pre-service science teachers. A total of 20 NOS elements were considered by the Chinese science teacher educators to be important ideas to be taught. It was also found that among these educators, whether focusing on the classical or contemporary NOS elements in NOS instruction was a prominent controversy. After explaining the criteria for differentiating between classical and contemporary NOS elements, this paper reports the specific NOS elements suggested by Chinese science teacher educators in this study. Afterward, it describes how all educators in this study were categorized in term of NOS content taught by them to pre-service science teachers. In the end, it discusses three factors influencing the decision on NOS content to be taught, i.e., view of the concept of NOS itself, vision of teaching NOS, and belief in general philosophy.

Wan, Zhi Hong; Wong, Siu Ling; Wei, Bing; Zhan, Ying

2013-12-01

49

Non-Hodgkins lymphoma of maxilla: A rare entity.  

PubMed

Non-Hodgkin's lymphomas are a group of neoplasms that originate from the cells of the lymphoreticular system. Forty percent of non-Hodgkin's lymphomas arise from extra nodal sites. Non-Hodgkin's lymphomas detected primarily in the bone are quite rare, but among jaw lesions, they are more frequently present in the maxilla than in the mandible. There are no classical characteristic clinical features of lymphomas involving the jaw bones. Swelling, ulcer or discomfort may be present in the region of the lymphoma, or it may mimic a periapical pathology or a benign condition. Extranodal non-Hodgkins lymphoma of the maxilla could present as one of the early manifestation of detrimental diseases. Clinically these types of lymphoma can mimic an inflammatory endo-periodontal lesion with symptoms of pain and local discomfort. The greater the delay in diagnosis subsequently worsens the prognosis. A case of maxillary non-Hodgkin's lymphoma with an unusual presentation is discussed. PMID:22639517

Agrawal, M G; Agrawal, S M; Kambalimath, Deepashri H

2011-07-01

50

The Interrelationship of Chinese Music and Poetry  

Microsoft Academic Search

Unlike its Western counterpart, Chinese poetry has a more important role in Chinese literary history, especially classical Chinese poetry, which dominated literature as well as art throughout history. However, when making an intratextual analysis of this genre, we find the generic roots of classical Chinese poetry have stemmed from music. The studies of the dichotomous nature of Chinese poetry and

YANPING WANG

51

Thomas Hodgkin: Social activist  

Microsoft Academic Search

Thomas Hodgkin's discovery of a lymphgl and disorder is merely one event in a life of unusually varied public activities in the social reform and humanitarian movements of the mid-19th century. He wrote pamphlets on medical care for the working-class poor, public health, housing, sanitation, and the relief of cold, hunger, and unemployment. Hodgkin wrote about the problems arising from

Louis Rosenfeld

2000-01-01

52

An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.  

PubMed

Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research. PMID:24063783

Jin, Rui; Lin, Zhi-jian; Xue, Chun-miao; Zhang, Bing

2013-09-01

53

Hodgkin Disease in Pregnancy  

MedlinePLUS

... effects on the unborn baby. But a few studies suggest that as long as very careful precautions are taken to aim the radiation precisely, limit the doses, and shield the baby, pregnant women with Hodgkin ...

54

Dorothy Crowfoot Hodgkin  

NASA Astrophysics Data System (ADS)

Born in 1910 in Cairo, Egypt, Dorothy Crowfoot Hodgkin would later be known as the third woman in history to win the Nobel Prize in Chemistry for her research on the structure of vitamin B-12. Her X-ray crystallography work also included discovering the molecular structure of penicillin and insulin. Dr. Hodgkin's work has aided in determining the structures of molecules for others to expand the technology necessary for today's medicine.

Montalvo, Jessica

2009-10-01

55

Hodgkin-like peripheral T-cell lymphoma (PTCL) with preserved Hodgkin-like lesions at autopsy: A case report with an interesting clinical course.  

PubMed

The presence of the so-called Hodgkin and Reed-Sternberg (H-RS) like cells may occur in T-cell non-Hodgkin lymphoma. Reported herein is the autopsy case of Hodgkin-like peripheral T-cell lymphoma (PTCL) in a 77-year-old male with gradual submandibular lymph node enlargement. The first biopsy showed Hodgkin-like PTCL, initially misdiagnosed as classical Hodgkin lymphoma. Although he was treated with a regimen of ABVD, his disease recurred with cervical lymph node enlargement. A second biopsy showed angioimmunoblastic T-cell lymphoma (AITL) and H-RS like cells became obscure. Despite treatment with the CHOP regimen, he died. An autopsy confirmed that only Hodgkin-like lesions preserved while the AITL component had disappeared. This clinical course is very interesting in that only the Hodgkin-like lesions were systematically exacerbated and became the main cause of death. There are no reports of Hodgkin-like PTCL following AITL and finally preserved Hodgkin-like lesions in autopsy. PMID:25434605

Mori, Daisuke; Matsuishi, Eijo; Akashi, Michiaki; Shibaki, Masami; Hirano, Takayuki; Ide, Mikiko; Tsutsumi, Yoko; Tsukiji, Hidenori; Gondo, Hisashi

2015-01-01

56

Vorinostat in Treating Patients With Relapsed or Refractory Advanced Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Favorable Prognosis Hodgkin Lymphoma; Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Adult Unfavorable Prognosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2014-05-07

57

Chinese Herbalism  

PubMed Central

Chinese herbalism dates back to 2852 B.C. More than 2,600 herbs and thousands of herbal formulae are used to treat illness. Classical theories of Chinese medicine are integrated with the Taoist philosophy, whereby the universe is composed of two basic forces: a positive one called yang, and a negative one called yin. Illness is thought to occur when there is too much yang (tonification) or too much yin (sedation) in the body and herbal medicines are therefore intended either to tonify or to sedate the body so that balance is restored. Since 1954, some Chinese herbal remedies have been scientifically analyzed and tested. Several have been proven effective in treating a variety of diseases and conditions. PMID:21283498

Cheng, Richard

1984-01-01

58

SGN-30 and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2014-09-30

59

Thomas Hodgkin: social activist.  

PubMed

Thomas Hodgkin's discovery of a lymph gland disorder is merely one event in a life of unusually varied public activities in the social reform and humanitarian movements of the mid-19th century. He wrote pamphlets on medical care for the working-class poor, public health, housing, sanitation, and the relief of cold, hunger, and unemployment. Hodgkin wrote about the problems arising from urban renewal and suburban development. His contributions to geographic explorations, anthropology, ethnology, and foreign affairs are virtually unknown today. Hodgkin's opposition to slavery and the slave trade involved him in the development of settlements in Africa for freed slaves and disputes with the abolitionists in America. He fought for social justice and human rights for native populations being oppressed by British foreign policy in South Africa and New Zealand. His criticism of the exploitation of Indians by the Hudson's Bay Company's fur trade contributed to a professional conflict in the highly politicized environment of Guy's Hospital and blocked advancement of his medical career. Closer to home he advocated reform of medical education and practice and sponsored adult education programs. As a member of its Senate, he helped in establishing London University, the first nonsectarian institution of higher learning in England. He lectured to working people on the means of preserving and promoting health and advocated prepaid medical care for the working poor. Concerned about unequal distribution of medical care, he opposed medical contracts to the lowest bidder and price-determined government plans for health care. He consistently maintained that the basic problems of the poor were not medical but socioeconomic. Since charity leaves nothing behind in exchange, Hodgkin was certain that greater benefits would result if charitable money was used to provide jobs. He denounced the evils of tobacco, practices of trade unions, and barbarous prize fights. On a trip to Jerusalem with Sir Moses Montefiore in 1866, Hodgkin contracted dysentery and died. He is buried in a protestant cemetery in Jaffa. His epitaph is fitting: "Nothing human was alien to him." PMID:10760325

Rosenfeld, L

2000-04-01

60

Alopecia areata as a paraneoplastic syndrome of Hodgkin’s lymphoma: A case report  

PubMed Central

Alopecia areata (AA) has been classically associated with several autoimmune disorders. However, AA as a paraneoplastic syndrome of Hodgkin’s lymphoma (HL) remains a rare entity and our understanding of this phenomenon is limited to a few case reports. This is the case report of a 46-year-old male patient who was diagnosed with AA several months prior to the onset of B symptoms and the diagnosis of stage IVB classical HL. The patient was subsequently treated with 6 cycles of adriamycin, bleomycin, vinblastine and dacarbazine and experienced a complete response and resolution of his AA. In our case, the onset of AA preceded the onset of systemic manifestations and diagnosis of HL, whereas in other cases AA was shown to occur concurrently with the clinical manifestations of HL. In all the cases, however, treatment of the HL subsequently led to resolution of the AA. The present case report highlights the significance of AA as a herald of underlying malignancy, although AA in classical HL remains poorly characterized in the literature. PMID:24940502

GONG, JUN; LIM, STEPHEN W.

2014-01-01

61

Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin's lymphoma: the  

E-print Network

1 Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non history, cancer, children, acute leukemia, Hodgkin's lymphoma, non- Hodgkin's lymphoma Abbreviations used: AL, acute leukemia; ALL, acute lymphoblastic leukemia; AML, acute myeloblastic leukemia; HL, Hodgkin

Paris-Sud XI, Université de

62

Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma  

ClinicalTrials.gov

Childhood Favorable Prognosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma

2013-10-24

63

Primary spinal epidural Hodgkin's lymphoma  

PubMed Central

Primary spinal epidural Hodgkin's lymphoma is very rare. We will discuss the clinical features and treatment of primary spinal epidural Hodgkin's lymphoma. In this paper, a 30-year-old male patient who presented with spinal epidural tumor at the T9–11 level is reported. Subtotal resection of the tumor was performed and the histological examination of the tumor specimen revealed Hodgkin's lymphoma. All other examinations were negative for an occult disease. Six courses of chemotheraphy containing adriamycin, bleomycin, vinblastine and dacarbazine were given to the patient. Surgery is the first therapeutic approach in malignancies compressing the spinal cord. Hodgkin's lymphoma is a very chemo- and radio-sensitive tumor. The indications for surgery were reduced and limited to laminectomy or even biopsy only, leaving the major role to chemo- and radiotheraphy. PMID:24964329

Yaman, Onur; Özdemir, Nail; Sevin, ?smail Ertan; Özer, Füsun Demirçivi; Ünlüo?lu, Saime

2013-01-01

64

[Thomas Hodgkin and his disease].  

PubMed

Thomas Hodgkin (1798-1866), born into a family of Quakers, would remain faithful all his life to the principles and rules of the 'Society of Friends'. He studied pharmacy and medicine in London, Edinburgh and Paris. As curator for the museum of pathological anatomy of Guy's Hospital (1825-1837) he introduced modern, organ-based, medicine in England, together with the clinicians Richard Bright and Thomas Addison. In 1832 Hodgkin reported autopsy findings of seven patients who had shown swollen lymph glands and an enlarged spleen, without evidence of tuberculosis, purulent inflammation or cancer. Later the diagnosis 'Hodgkin's disease' would be restricted to lymphomas with giant, multinucleated Reed-Sternberg cells on microscopic examination. Especially in his later years, Hodgkin devoted much time and effort to the emancipation of oppressed or destitute minorities, especially abroad. He died of dysentery on a journey to Palestine and lies buried in Jaffa. PMID:22495009

van Gijn, Jan; Gijselhart, Joost P

2012-01-01

65

Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma

2014-09-08

66

Familial Hodgkin's lymphoma in Scandinavia.  

PubMed

From 2005 to 2010, eight families with clustering of Hodgkin's lymphoma and other lymphoproliferative disorders were found: Hodgkin's lymphoma 9 cases, chronic lymphocytic leukemia 8, non-Hodgkin's lymphoma 3, and multiple myeloma 1 case. Seven cases of Hodgkin's lymphoma, all males, were seen in pleiotropic pairs of affected family members from two successive generations; two patients were sisters. Five of the seven pairs showed sign of anticipation. The 7 males with Hodgkin's lymphoma were found in 5 patrilineal pairs and 2 matrilineal pairs; 6 parent-offspring pairs and 1 uncle-nephew pair. In contrast to the matrilineal pairs, all patrilineal pairs, apart from one family with an only child, had healthy older siblings in accordance with a birth-order effect. The association among Hodgkin's lymphoma, males, and other lymphoproliferative disorders undoubtedly reflects genotypic traits of the susceptibility. A non-Mendelian segregation is discussed comprising genomic parental imprinting and incomplete penetrance susceptibility in both familial and solitary cases. PMID:21576419

Jønsson, Viggo; Awan, Haneef; Nyquist, Emil; Maisenhølder, Martin; Johannesen, Tom B; Ly, Bernt; Tjønnfjord, Geir E

2011-01-01

67

Clinical and Pathologic Studies in Non-Hodgkin's Lymphoma Patients Receiving Antibody Treatment  

ClinicalTrials.gov

Lymphoma, Non-Hodgkin; Lymphomas: Non-Hodgkin; Lymphomas: Non-Hodgkin Cutaneous Lymphoma; Lymphomas: Non-Hodgkin Diffuse Large B-Cell; Lymphomas: Non-Hodgkin Follicular / Indolent B-Cell; Lymphomas: Non-Hodgkin Mantle Cell; Lymphomas: Non-Hodgkin Marginal Zone; Lymphomas: Non-Hodgkin Peripheral T-Cell; Lymphomas: Non-Hodgkin Waldenstr Macroglobulinemia

2011-05-31

68

Brentuximab Vedotin Treatment for Primary Refractory Hodgkin Lymphoma  

PubMed Central

Up to 40% of patients with advanced Hodgkin lymphoma (HL) become refractory or relapsed after current standard chemotherapy, among which primary refractory HL confers a particularly poor outcome. With intensive salvage chemotherapy and autologous stem cell transplantation, the long-term remission rate for these patients was only 30%, but more selective treatments with higher therapeutic index are needed. We report the experience of using a new anti-CD30 immunotoxin, brentuximab vedotin, in salvage treatment of a 30-year-old woman with primary refractory Hodgkin lymphoma. The patient presented with SVC syndrome due to the bulky mediastinal tumor and was confirmed to have classical Hodgkin lymphoma, nodular sclerosis type, stage IIIA. The tumor responded to induction chemotherapy transiently, but local progression was noted during subsequent cycles of treatment. Salvage radiotherapy to the mediastinal tumor, obtained no remission but was followed by rapid in-field progression and then lung metastasis. She declined stem cell transplantation and received salvage brentuximab vedotin (BV) therapy, which induced dramatic shrinkage of tumor without significant side effects. Serial followup of PET/CT imaging confirmed a rapid and continuous complete remission for 12 months. Although durability of the remission needs further observation, this case illustrates the excellent efficacy of brentuximab vedotin in primary refractory Hodgkin lymphoma. PMID:24198983

Yeh, Shyh-An; Chen, Huei-Yung

2013-01-01

69

Focusing on the Classical or Contemporary? Chinese Science Teacher Educators' Conceptions of Nature of Science Content to Be Taught to Pre-Service Science Teachers  

ERIC Educational Resources Information Center

Drawing from the phenomenographic perspective, an exploratory study investigated Chinese teacher educators' conceptions of teaching Nature of Science (NOS) to pre-service science teachers through semi-structured interviews. Five key dimensions emerged from the data. This paper focuses on the dimension, "NOS content to be taught to…

Wan, Zhi Hong; Wong, Siu Ling; Wei, Bing; Zhan, Ying

2013-01-01

70

Asthma combined with Hodgkin’s lymphoma: a case report and review of the literature  

PubMed Central

Both asthma and hematological malignancies are influenced by genetic and environmental factors. The previous studies have revealed lymphoma were found among atopic men and women. However, the relationship between asthma and Hodgkin’s lymphoma has not been well recognized. We present here, a case of a 53-year-old male patient suffered asthma and then Hodgkin’s lymphoma. PMID:24416525

Gu, Shuyi; Guo, Yi; Wan, Huanying

2013-01-01

71

Peripheral T Cell Non-Hodgkin's Lymphoma following Treatment of Hodgkin's Lymphoma  

PubMed Central

Previous reports have suggested that non-Hodgkin's lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that occurred in a patient metachronously. Peripheral T cell lymphoma (PTCL) of the patient was found about 2 years after treatment of classical HL. When the patient was diagnosed with HL, biopsy revealed typical RS cells, presenting positive for CD30 and CD15 and negative for CD79a and CD3 in immunohistochemistry. And PCR analysis showed IgH gene rearrangement; however, T cell receptor gene rearrangement and Epstein-Barr virus (EBV) were not detected on PCR analysis. After 2 years of treatment of HL, colonoscopic biopsy and lymph node biopsy showed CD3 positive atypical cells intermixed with small reactive lymphoid cells and plasma cells, indicating T cell lymphoma. PCR analysis demonstrated T cell receptor gene rearrangement and did not detect EBV. Although it is rare, synchronous or metachronous HL and NHL may occur. Therefore, we may need to ensure pathological confirmation, especially in case of lymphoma that did not respond to chemotherapy.

Chang, Sun Hee; Lee, Hye Ran

2015-01-01

72

Drugs Approved for Non-Hodgkin Lymphoma  

MedlinePLUS

... Cancer Terms NCI Drug Dictionary Drugs Approved for Non-Hodgkin Lymphoma This page lists cancer drugs approved ... Zolinza (Vorinostat) Zydelig (Idelalisib) Drug Combinations Used in Non-Hodgkin Lymphoma CHOP COPP CVP EPOCH Hyper-CVAD ...

73

Primary extra nodal Hodgkin disease: Bone presentation  

PubMed Central

Summary Background Extra nodal and extra lymphatic propagation of Hodgkin’s disease is a characteristic of the fourth stage of disease when the organs are affected. Primary appearances of the disease outside the lymph node is a rare event. Therefore, it makes diagnostic problem. Skeletal system is possible localization of primary extra nodal Hodgkin’s disease. Case Report Women, 42-years-old, was admitted to hospital because of swelling and pain in the right shoulder. After imaging and histological examination diagnosed Hodgkin’s nodular sclerosing histological subtype disease has been established. The patient starts to receive chemotherapy. Conclusions Primary extra nodal Hodgkin’s disease of bone is manifested with painful swelling in geared area. Imaging method shows destruction of the affected bone, with swelling of the soft tissues. Propagation in soft tissue is not accompanied by their destruction, but rather manifested swelling of the surrounding soft tissue. PMID:24808935

Nikolica, Goran; Badnjar, Zorka; Cadjenovic, Tanja; Raceta-Masic, Dijana

2014-01-01

74

Hodgkin lymphoma in pregnancy.  

PubMed

The peak incidence of Hodgkin lymphoma (HL) coincides with reproductive years, and as many as 3 % of all HL patients present with concurrent pregnancy. The management of a pregnant patient with HL requires a multidisciplinary approach combining expertise in medical oncology, high-risk obstetrics, and neonatology, as well as effective communication with the patient and her family. The goal is to optimize the mother's chance of a cure while allowing for delivery of a healthy child. A pregnant patient with HL should be staged by clinical examination and judicious use of non-radiation imaging such as ultrasound, balancing the need for accurate disease assessment with the need to minimize invasive procedures. The treatment strategy is individualized to the symptoms, lymphoma stage, gestational age and the patients' wishes. Therapeutic options include treatment deferral or single-agent vinblastine with reservation of multi-agent chemotherapy until the second or third trimester for the small minority of patients with aggressive clinical presentation. PMID:23749243

Bachanova, Veronika; Connors, Joseph M

2013-09-01

75

Fluorine18 fluorodeoxyglucose positron emission tomography, gallium-67 scintigraphy, and conventional staging for Hodgkin’s disease and non-Hodgkin’s lymphoma  

Microsoft Academic Search

PurposeTo compare fluorine-18 fluorodeoxyglucose positron emission tomography (PET) and gallium scanning with each other and with conventional staging, for patients with Hodgkin’s disease or non-Hodgkin’s lymphoma.

Andrew Wirth; John F Seymour; Rodney J Hicks; Robert Ware; Richard Fisher; Miles Prince; Michael P MacManus; Gail Ryan; Henry Januszewicz; Max Wolf

2002-01-01

76

Hodgkin's Lymphoma Presenting as Alopecia  

PubMed Central

Alopecia is a rare manifestation of Hodgkin's disease. It may be due to follicular destruction due to direct infiltration by the disease, or it may be a secondary or paraneoplastic manifestation. In this patient, hair loss, diffuse yperpigmentation, and generalized itching preceded other manifestations of the disease. The pattern of hair loss was diffuse and generalized in nature involving scalp, eyebrows, axilla, and groin. Subsequently, the patient was diagnosed to be a case of Hodgkin's lymphoma, based on clinical and histopathological features. Earlier reports on alopecia accompanying Hodgkin's disease have also been discussed. This case highlights the importance of keeping a high suspicion of an underlying malignancy in patients presenting with such cutaneous manifestations. PMID:23180928

Garg, Sunny; Mishra, Sourav; Tondon, Ravi; Tripathi, Kamlakar

2012-01-01

77

5-Year Relative Survival, Detailed Hodgkin Lymphoma Subtypes, Both Sexes  

Cancer.gov

Lymphoid Neoplasm 169,687 68.1 ( 67.8 , 68.4) 89.0 ( 88.3 , 89.7) 75.8 ( 75.4 , 76.1 ) 57.4 ( 56.9 , 57.9) 1 Hodgkin Lymphoma 14,949 85.3 ( 84.6 , 86.0) 96.4 ( 95.3 , 97.3) 89.4 ( 88.7 , 90.1 ) 52.8 ( 49.9 , 55.6) 1(a) Classical Hodgkin lymphoma 14,242 84.8 ( 84.1 , 85.5) 96.2 ( 95.0 , 97.1) 89.0 ( 88.3 , 89.7 ) 51.6 ( 48.5 , 54.6) 1(a)1.

78

Traditional Chinese medicine  

Microsoft Academic Search

The classical Chinese pharmacopoeia describes a large number of herbal formulations that are used for the treatment of a wide variety of diseases. This therapeutic approach is ignored by many and considered to be an alternative to conventional medicine by others. The scientific proof and clinical validation of these herbal formulations require a rigorous approach that includes chemical standardization, biological

Robert Yuan; Yuan Lin

2000-01-01

79

Chinese Americans.  

ERIC Educational Resources Information Center

This book on the Chinese Americans focuses on such aspects of intergroup relations, community characteristics, social problems, acculturation, racial and social discrimination, and economic opportunities for the ethnic group as: the Chinese diaspora; forerunners of overseas Chinese community organization; Chinese community organization in the…

Lyman, Stanford M.

80

Drugs Approved for Hodgkin Lymphoma  

Cancer.gov

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

81

What You Need to Know about Non-Hodgkin Lymphoma  

MedlinePLUS

... Groups Español What You Need To Know About™ Non-Hodgkin Lymphoma This booklet is about non-Hodgkin lymphoma, a cancer that starts in the immune system. Non-Hodgkin lymphoma is also called NHL. Booklet Date: ...

82

What Are the Key Statistics about Non-Hodgkin Lymphoma?  

MedlinePLUS

... for non-Hodgkin lymphoma? What are the key statistics about non-Hodgkin lymphoma? Non-Hodgkin lymphoma (NHL) ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...

83

Bortezomib, Ifosfamide, and Vinorelbine Tartrate in Treating Young Patients With Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Therapy  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Lymphocyte Predominant Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma

2014-06-18

84

Dorothy Reed and Hodgkin’s disease: a reflection after a century  

Microsoft Academic Search

It has now been 100 years since Dorothy Reed, at the age of 28, wrote her paper on Hodgkin’s disease. Her biography reveals the difficult lives of women entering the hitherto male-dominated field of medicine, let alone medical research. Her historic paper on Hodgkin’s disease is remarkable for its brilliant observations and concise scientific reasoning. Nevertheless, she was told that

Matjaz Zwitter; Joel R Cohen; Ann Barrett; Elizabeth D Robinton

2002-01-01

85

Chinese Literature  

ERIC Educational Resources Information Center

The earliest recorded Chinese literature that has survived consists of folk songs mixed with verses and rhymes. Two factors determined the general pattern of subsequent development in Chinese literature: the nature of the written Chinese language and the establishment of the Confucian school as the orthodoxy in literary criticism. By 1800 there…

Hsu, Kai-yu

86

Staging laparotomy in Hodgkin's disease.  

PubMed

Staging laparotomy (multiple liver and lymph node biopsies and splenectomy) was performed at the North Carolina Baptist Hospital in 123 patients with Hodgkin's disease. There were no deaths. Wound, pulmonary, intra-abdominal or urinary tract complications developed in 17 patients. Of those complications, one case each of pelvic abscess, subphrenic abscess, small bowel obstruction, staphylococcal peritonitis and subphrenic hematoma required a major intra-abdominal operation. The patients were classified on the basis of histopathology; nodular sclerosis--40, mixed cellularity--44, lymphocyte predominant--24, lymphocyte depleted--13, and undetermined--2. The pathological stage following laparotomy was unchanged from the clinical stage in 62%, reduced in 15%, and advanced in 23%. Subsequent therapy, therefore, was altered in 38% of the patients. Lymphangiography, done in 108 patients, showed lymph node involvement in 46 patients and no involvement in 62 patients. Of those lymphangiographic findings, 79% were confirmed histopathologically, 19% were falsely positive, and 1.8% were falsely negative. There were positive findings of Hodgkin's disease in the spleen in 42% of patients. The staging laparotomy continues to be a valuable tool in the staging and treatment of Hodgkin's disease. PMID:7369820

Sterchi, J M; Myers, R T

1980-05-01

87

Staging laparotomy in Hodgkin's disease.  

PubMed Central

Staging laparotomy (multiple liver and lymph node biopsies and splenectomy) was performed at the North Carolina Baptist Hospital in 123 patients with Hodgkin's disease. There were no deaths. Wound, pulmonary, intra-abdominal or urinary tract complications developed in 17 patients. Of those complications, one case each of pelvic abscess, subphrenic abscess, small bowel obstruction, staphylococcal peritonitis and subphrenic hematoma required a major intra-abdominal operation. The patients were classified on the basis of histopathology; nodular sclerosis--40, mixed cellularity--44, lymphocyte predominant--24, lymphocyte depleted--13, and undetermined--2. The pathological stage following laparotomy was unchanged from the clinical stage in 62%, reduced in 15%, and advanced in 23%. Subsequent therapy, therefore, was altered in 38% of the patients. Lymphangiography, done in 108 patients, showed lymph node involvement in 46 patients and no involvement in 62 patients. Of those lymphangiographic findings, 79% were confirmed histopathologically, 19% were falsely positive, and 1.8% were falsely negative. There were positive findings of Hodgkin's disease in the spleen in 42% of patients. The staging laparotomy continues to be a valuable tool in the staging and treatment of Hodgkin's disease. PMID:7369820

Sterchi, J M; Myers, R T

1980-01-01

88

The Pathology and Nomenclature of Hodgkin's Disease  

Microsoft Academic Search

Summary The diverse morphologic expressions of Hodgkin's disease have been reviewed and compared to the numerous histologie terms in the literature and the author's recently proposed histologie types. The relationship of the histologie findings to the clinical stages and survival has also been analyzed. The histologie ex pressions of the Hodgkin's disease process appear to be reparable into the following

ROBERT J. LUKES; JAMES J. BUTLER

89

Rovac is the possible ancestor of the Russian lapinized vaccines LK-VNIVViM and CS strains but not the Chinese strain (C-strain) vaccine against classical swine fever.  

PubMed

Classical swine fever (CSF), or hog cholera, is a highly contagious disease that emerged in the first half of the nineteenth century. To fight against the disease and protect pigs, different vaccines were developed, including early generation of lapinized Rovac strain and the later development of the “Chinese” strain (C-strain). However, details of the development of these vaccines are lost in history. In order to investigate the phylogenetic relationship between the Rovac and other lapinized vaccines, this study determined the genome sequence of the Rovac, which comprised 12,304 nucleotides, notably with the 3?untranslated region (3?UTR) containing a 13-nucleotide insertion. The near-complete genome of Russian vaccine strain LK-VNIVViM was determined by next-generation sequencing on Illumina MiSeq platform. Whole genome phylogenetic analysis revealed a closer relationship of the Rovac strain with the Russian LK-VNIVViM, CS strain and its derivative RUCSFPLUM (genotype 1.2), rather than with the C-strain (genotype 1.1). In addition, it demonstrated an ancestry role of the LK-VNIVViM in relation to the CS strain and RUCSFPLUM. The study suggested that the Rovac vaccine is the possible ancestor of the Russian vaccine strains but not the C-strain vaccine. PMID:25306909

Zhou, Weiguang; Gao, Shandian; Podgórska, Katarzyna; Stadejek, Tomasz; Qiu, Hua-Ji; Yin, Hong; Drew, Trevor; Liu, Lihong

2014-11-20

90

Hodgkin's Lymphoma: A Review of Neurologic Complications.  

PubMed

Hodgkin's lymphoma is a hematolymphoid neoplasm, primarily of B cell lineage, that has unique histologic, immunophenotypic, and clinical features. Neurologic complications of Hodgkin's Lymphoma can be separated into those that result directly from the disease, indirectly from the disease, or from its treatment. Direct neurologic dysfunction from Hodgkin's Lymphoma results from metastatic intracranial spinal disease, epidural metastases causing spinal cord/cauda equina compression, leptomeningeal metastases, or intradural intramedullary spinal cord metastases. Indirect neurologic dysfunction may be caused by paraneoplastic disorders (such as paraneoplastic cerebellar degeneration or limbic encephalitis) and primary angiitis of the central nervous system. Hodgkin's lymphoma treatment typically includes chemotherapy or radiotherapy with potential treatment-related complications affecting the nervous system. Neurologic complications resulting from mantle-field radiotherapy include the "dropped head syndrome," acute brachial plexopathy, and transient ischemic attacks/cerebral infarcts. Chemotherapy for Hodgkin's lymphoma may cause cerebral infarction (due to emboli from anthracycline-induced cardiomyopathy) and peripheral neuropathy. PMID:20975772

Grimm, Sean; Chamberlain, Marc

2011-01-01

91

Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-? peptide (1–42-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway  

PubMed Central

Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. However, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with A?1–42 (10 µmol/L) significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN (2 µL/mL), specifically by the component geniposide (26 µmol/L), but not ginsenoside Rg1 (2.5 µmol/L). The estrogen receptor inhibitor, ICI182780 (1 µmol/L), did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under A?1–42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002 (50 µmol/L) or U0126 (10 µmol/L), respectively blocked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results suggest that the non-classical estrogen pathway (i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against A?1–42-mediated cell death in primary cultured hippocampal neurons. PMID:25206841

Li, Jiao; Wang, Feng; Ding, Haimin; Jin, Chunyan; Chen, Jinyan; Zhao, Yanan; Li, Xiaojing; Chen, Wenju; Sun, Ping; Tan, Yan; Zhang, Qi; Wang, Xu; Fan, Angran; Hua, Qian

2014-01-01

92

Simultaneous Detection and Differentiation of Highly Virulent and Classical Chinese-Type Isolation of PRRSV by Real-Time RT-PCR  

PubMed Central

Porcine reproductive and respiratory syndrome (PRRS) is a leading disease in pig industry worldwide and can result in serious economic losses each year. The PRRS epidemic situation in China has been very complicated since the unprecedented large-scale highly pathogenic PRRS (HP-PRRS) outbreaks in 2006. And now the HP-PRRS virus (HP-PRRSV) and classical North American type PRRSV strains have coexisted in China. Rapid differential detection of the two strains of PRRSV is very important for effective PRRS control. The real-time RT-PCR for simultaneous detection and differentiation of HP-PRRSV and PRRSV by using both SYBR Green and TaqMan probes was developed and validated. Both assays can be used for rapid detection and strain-specific identification of HP-PRRSV and PRRSV. However, the TaqMan probe method had the highest detection rate whereas the conventional RT-PCR was the lowest. The real-time RT-PCR developed based on SYBR Green and TaqMan probe could be used for simultaneous detection and differentiation of HP-PRRSV and PRRSV in China, which will benefit much the PRRS control and research. PMID:25114934

Xiao, Shuqi; Chen, Yaosheng; Wang, Liangliang; Gao, Jintao; Mo, Delin; He, Zuyong; Liu, Xiaohong

2014-01-01

93

On the mathematical aesthetic in traditional Chinese art  

Microsoft Academic Search

The mathematical rhythm is a worldwide artistic language. In this study, many Mathematical rhythms existing in traditional Chinese art are analysed, including lines, proportion, symmetry, infinity, cycle and numbers. The integration of classical Chinese art and mathematical rhythms makes the art presents a unique beauty-the mathematical aesthetic, which reveals the rational and scientific thinking of Chinese ancestors. This may lead

Wei Huang; Jinsheng Zhang; Yingxin Zhao

2009-01-01

94

Hodgkin disease of the trachea.  

PubMed

Endobronchial Hodgkin disease (HD) is very rare. We report the case of a women who presented with life-threatening airway obstruction. She was diagnosed with HD 4 years earlier and was in remission after treatment with a combination of chemotherapy and radiation. Bronchoscopy showed a polypoid mass obstructing the tracheal lumen almost completely. The mass was resected using an electrocautery snare loop, providing immediate relief of symptoms. Pathology and staging investigations revealed HD isolated to the trachea. This presentation and treatment is extremely unique for HD. PMID:23207461

Boujaoude, Ziad; Malin, Jessica; Abouzgheib, Wissam

2012-07-01

95

Unusual primary osseous Hodgkin’s lymphoma: A case report  

PubMed Central

Hodgkin’s lymphoma (HL) is one of the few adult malignancies that most frequently presents with a progressive, painless enlargement of the peripheral lymph nodes. A primary osseous presentation of HL, without lymph node involvement, is extremely rare. The present study describes a case of primary multifocal osseous HL in a 22-year-old female. The patient presented with pain in the lumbar-sacral-pelvic area and a prolonged fever. Pathological examination led to a diagnosis of primary multifocal osseous lymphoma, and the patient was subsequently prescribed a course of Adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy. Following this, the patient recovered with no pain or fever, and computed tomography identified no further progression. The clinical, radiological and histological features of HL are similar to those of other medical conditions, such as tuberculosis and eosinophilic granuloma. Furthermore, in rare cases, HL may even occur in combination with multiple myeloma. This makes it difficult to diagnose the condition, which often leads to a delay in treatment. Clinicians should not ignore HL when it manifests in the unusual primary osseous form.

LUO, WEI; ZHANG, FANGJIE; SUN, JINPENG; HE, HONGBO

2015-01-01

96

Non-Hodgkin's lymphomas following radiation therapy alone for Hodgkin's disease.  

PubMed

We have recently treated three patients who developed a non-Hodgkin's lymphoma after therapy with radiation alone for Hodgkin's disease. The secondary non-Hodgkin's lymphomas occurred 4 years (two patients) and 11.5 years after receiving irradiation. Thirteen additional cases have been reported and are reviewed with attention to the subsequent histology and response to treatment of these secondary non-Hodgkin's lymphomas. The pathogenesis is unknown, but, may be therapy-related or part of the natural history of the lymphocyte predominance subtype of Hodgkin's disease. Possible mechanisms will be discussed. A subset of the patients with secondary lymphomas following radiation therapy alone are curable with chemotherapy. New sites of disease after apparent control of Hodgkin's disease require pathology for confirmation of the disease process and appropriate therapy. PMID:3749524

Trenkner, D A; Brownell, M; Wasserman, T H

1986-07-01

97

Classical Conditioning  

NSDL National Science Digital Library

!!Classical Conditioning!! Classical conditioning is the use of Pavlovian conditioning procedures where a neutral stimulus becomes capable of evoking a response through pairing with an unconditioned stimulus. Click the link below to get an introduction into classical conditioning. Introduction to Classical Conditioning Now that you\\'ve been introduced to classical conditioning, view the clip at the link below, ...

Mrs. Palacios, Miss Miller, Mr. Rowser

2008-04-01

98

Hodgkin’s Lymphoma in Older Patients: an Orphan Disease?  

PubMed Central

Hodgkin Lymphoma HL can be cured in the large majority of younger patients, but prognosis for older patients, especially those with advanced-stage disease, has not improved substantially. The percentage of HL patients aged over 60 ranges between 15% and 35%. A minority of them is enrolled into clinical trials. HL in the elderly have some specificities: more frequent male sex, B-symptoms, advanced stage, sub diaphragmatic presentation, higher percentage of mixed cellularity, up to 50% of advanced cases associated to EBV. Very old age (>70) and comorbidities are factor of further worsening prognosis. Like in younger patients, ABVD is the most used protocol, but treatment outcome remains much inferior with more frequent, severe and sometimes specific toxicities. Few prospective studies with specific protocols are available. The main data have been published by the Italian Lymphoma Group with the VEPEMB schedule and the German Hodgkin Study Group with the PVAG regimen. Recently, the Scotland and Newcastle Lymphoma Study Group published the SHIELD program associating a prospective phase 2 trial with VEPEMB and a prospective registration of others patients. Patients over 60y with early-stage disease received three cycles plus radiotherapy and had 81% of 3-year overall survival (OS). Those with advanced-stage disease received six cycles, with 3-year OS of 66%. The role of geriatric and comorbidity assessment in the treatment’s choice for HL in the elderly is a major challenge. The combination of loss of activities of daily living combined with the age stratification more or less 70y has been shown as a simple and effective survival model. Hopes come from promising new agents like brentuximab-vedotin (BV) a novel antibody-drug conjugate. The use of TEP to adapt the combination of chemotherapy and radiotherapy according to the metabolic response could also be way for prospective studies. PMID:25045458

Thyss, Antoine; Saada, Esma; Gastaud, Lauris; Peyrade, Frédéric; Re, Daniel

2014-01-01

99

An Unusual Presentation of Endobronchial Hodgkin's Lymphoma.  

PubMed

Endobronchial involvement of Hodgkin's lymphoma is a rare presentation of the disease. However, it needs to be considered in patients presenting with non-resolving pneumonia in the setting of Hodgkin's disease. In such cases, clinicians need to ensure adequate and multiple biopsies as patients may have co-existent pulmonary infection and disease involvement. A 16 years old patient reported with a history of relapsed Hodgkin's disease, with bilateral pulmonary infiltrates, that failed to resolve after empiric antibiotic therapy. Positron Emission Tomography (PET) scan was performed demonstrating equivocal uptake in left upper lobe. Bronchoscopy revealed a necrotic endobronchial mass. Initial biopsy only revealed necrotic inflammatory debris, however, since the patient continued to lose weight, repeat biopsy was performed which demonstrated CD 30 positive Hodgkin's lymphoma cells. PMID:25518781

Awan, Shazia; Wahla, Ali Saeed

2014-11-01

100

Differentiation between sarcoidosis and Hodgkin’s lymphoma based on mediastinal lymph node involvement pattern: Evaluation using spiral CT scan  

PubMed Central

Summary Background: The purpose of this study was to determine the specific and detailed anatomic sites and morphologic characteristics of mediastinal lymph nodes on spiral computed tomography for the purpose of differentiation between sarcoidosis and Hodgkin’s lymphoma. Material/Methods: Anatomical distribution of mediastinal lymph nodes on spiral CT was reviewed in 39 patients with sarcoidosis and 37 patients with Hodgkin’s lymphoma using the International Association for the Study of Lung Cancer (IASLC) lymph node map. Other morphologic features such as lymph node calcification or coalescence of adjacent lymph nodes were also compared. Results: Zone 10 was involved more often in sarcoidosis than in Hodgkin’s lymphoma. On the other hand, there was a higher tendency for presence of zone 1 and 3 as well as retrocrural and internal mammary lymphadenopathy in Hodgkin’s lymphoma than in sarcoidosis. Sarcoidosis presented with intranodal calcifications more often than Hodgkin’s lymphoma. Coalescence, pressure effect on adjacent structures and central cavitations were significantly more common in Hodgkin’s lymphoma. Conclusions: Findings of the present study indicate that specific anatomical distribution and morphological patterns of mediastinal lymph nodes, as demonstrated on spiral CT, can be useful in differentiating sarcoidosis from Hodgkin’s lymphoma. PMID:24115955

Mehrian, Payam; Ebrahimzadeh, Seyed Amir

2013-01-01

101

Memristor, Hodgkin-Huxley, and Edge of Chaos  

NASA Astrophysics Data System (ADS)

From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm’s law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of ‘pinched’ hysteresis loops in the v-i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin-Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin-Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling ‘Goldilocks zone’, dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors.

Chua, Leon

2013-09-01

102

Memristor, Hodgkin-Huxley, and edge of chaos.  

PubMed

From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm's law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of 'pinched' hysteresis loops in the v-i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin-Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin-Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling 'Goldilocks zone', dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors. PMID:23999613

Chua, Leon

2013-09-27

103

[Changes in the breast in Hodgkin's and non-Hodgkin's lymphoma].  

PubMed

The results of mammography, infrared thermography, cytology and histology are compared for 13 patients with secondary Hodgkin's disease and for 4 patients with primary and 9 with secondary Non-Hodgkin lymphoma. It was found, that an accurate diagnosis can be achieved only by cytology and histology PMID:2710928

Hérics, I; Péter, I; Semjonow, I; Szántó, I

1989-01-01

104

What You Need to Know about Hodgkin Lymphoma  

MedlinePLUS

... a doctor visit. This booklet is not about non-Hodgkin lymphoma. Non-Hodgkin lymphoma is a different disease with different treatments options. For the latest information about non-Hodgkin lymphoma, visit: http://www.cancer.gov/cancertopics/types/non- ...

105

[Granulocyte turnover in advanced Hodgkin's disease].  

PubMed

In 30 adult patients with III and IV Hodgkin's disease the studies of granulocytic turnover were performed. Bone marrow storage pool was measured by hydrocortisone test. Total blood granulocyte pool was judged by the estimation of muramidase activity and serum unsaturated vitamin B12 binding capacity. The epinephrine test was used for the marginated granulocyte pool determination. The circulating granulocyte pool was calculated from the count of granulocytes in the samples of venous blood. The tissue mobilization of granulocytes was measured by Senn's et al. method. After hydrocortisone application the releasing of the mature granulocytes from the bone-marrow was significantly lower in patients with Hodgkin's disease than in controls. The circulating and marginated pools of granulocytes in Hodgkin's disease did not differ from the normal persons. The tissue migration of granulocytes was decreased in patients with Hodgkin's disease. It is concluded that these abnormalities of granulocytic turnover in advanced Hodgkin's disease may be considered to be an additional cause of the defence mechanism in this disease. PMID:7314751

Prazmowska-Owczarek, B; Hansz, J

1981-09-15

106

AIDS related systemic non-Hodgkin's lymphoma  

PubMed Central

Objective: To review the current literature on HIV associated non-Hodgkin's lymphoma. Methods: A comprehensive Medline/Pubmed search of articles pertaining to HIV associated non-Hodgkin's lymphoma as well as personal experience from the treatment of over 200 patients at the Chelsea and Westminster Hospital, one of the largest centres for the management of HIV disease in Europe. Conclusion: High grade B cell non-Hodgkin's lymphoma is the second commonest tumour affecting people with HIV. The incidence of this tumour is not declining following the introduction of highly active antiretroviral therapy. Chemotherapy has been employed with modest success in this group of patients; however, the prognosis remains worse than for immunocompetent patients. Advances in molecular genetics and virology have led to a greater understanding of the biology of these tumours. However, these advances have yet to be translated into improvements in the clinical management of patients with AIDS associated non-Hodgkin's lymphoma. Key Words: AIDS; HIV; non-Hodgkin's lymphoma PMID:11141847

Powles, T.; Matthews, G.; Bower, M.

2000-01-01

107

Novel therapy for Hodgkin lymphoma.  

PubMed

The treatment of Hodgkin lymphoma (HL) relies on multimodality treatment with standard chemotherapy, radiation therapy, and autologous or allogeneic stem cell transplantation in cases of relapsed disease. Genomic advances in HL provided insights into deregulation of key nodal signaling pathways, including the PI3K, NF-?B, and JAK/STAT pathways, which are amenable to small-molecule targeting. Understanding how HL cells interact and depend on their microenvironment for survival signals and immune protection may uncover other such pathways. Small-molecule targeting has the potential to dramatically improve treatment outcomes, especially in patients with highly refractory disease and those with poor tolerance to existing chemotherapies. As novel therapies continue to be developed for HL, the challenge will be to address the needs of high-risk groups, reduce long-term therapy-related morbidity, position current established treatments with novel therapies, and concurrently develop biomarkers to aid in patient selection. Brentuximab vedotin, which was approved in 2011, is already shifting the treatment paradigm of HL. Undoubtedly, other novel therapeutics in the pipeline will affect positively the landscape of treatment in HL. PMID:24319210

Batlevi, Connie Lee; Younes, Anas

2013-01-01

108

Prognostic Factors in Hodgkin Lymphoma  

PubMed Central

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise. PMID:25045461

Cuccaro, Annarosa; Bartolomei, Francesca; Cupelli, Elisa; Galli, Eugenio; Giachelia, Manuela; Hohaus, Stefan

2014-01-01

109

Non-Hodgkin Lymphoma (NHL) in Pakistan  

PubMed Central

Lymphomas are classified as Hodgkin’s and Non-Hodgkin’s lymphomas (HL; NHL); NHL being further sub-divided into B, T and Null cell categories on the basis of WHO classification. With a few exceptions worldwide, B-NHL are more common, accounting approximately 80-85% of all cases of NHL compared to T-NHL, which accounts for about 10-15% of all NHL cases. The incidence of NHL has shown a steady increase and attention is being focused on the possible causes of this increase. Epidemiologic studies indicate that environmental factors do play a role in the causation of NHL, such as drugs, pesticides, solvents, hair dyes, viruses (EBV, HTLV-1, Hepatitic C and HIV) and Helicobacter pylori. Hence many different environmental factors of risk acting on large segments of the population can contribute for increase of NHL. PMID:24551760

Pervez, Shahid

2012-01-01

110

Late complications of Hodgkin's disease management  

SciTech Connect

In the past several decades, Hodgkin's disease has been transformed from a uniformly fatal illness to one that can be treated with the expectation of long-term remission or cure in the majority of patients. Because patients now survive for long periods after curative intervention, various complications have been identified. The spectrum of complications following curative therapy is quite diverse and includes immunologic, cardiovascular, pulmonary, thyroid, and gonadal dysfunction. In addition, second malignant neoplasms in the form of acute leukemia as well as secondary solid tumors have now been documented to occur with increased frequency in patients cured of Hodgkin's disease. 80 references.

Young, R.C.; Bookman, M.A.; Longo, D.L. (Fox Chase Cancer Center, Philadelphia, PA (USA))

1990-01-01

111

Mandarin Chinese Dictionary: English-Chinese.  

ERIC Educational Resources Information Center

This dictionary is a companion volume to the "Mandarin Chinese Dictionary (Chinese-English)" published in 1967 by Seton Hall University. The purpose of the dictionary is to help English-speaking students produce Chinese sentences in certain cultural situations by looking up the English expressions. Natural, spoken Chinese expressions within the…

Wang, Fred Fangyu

112

Aneuploidy in sperm of Hodgkin`s disease patients receiving NOVP chemotherapy  

SciTech Connect

Induction of genetic damage in germ cells of young patients receiving chemo- or radiotherapy for cancers with probable cure, such as Hodgkin`s disease, is cause for concern. These young patients may someday desire children, and germ cell alterations presenting as numerical chromosomal abnormalities in sperm may place their future offspring at risk. To address this concern, we measured aneuploidy in sperm from eight young Hodgkin`s disease patients: four pre-treatment, four during treatment, and three over a 45 month period following treatment with NOVP (Novantrone, Oncovin, Vinblastine and Prednisone). Patients ranged in stage of disease from IA-IIEB and none had received prior radiation or chemotherapy. Using multi-chromosome sperm FISH with repetitive sequence probes specific for chromosomes X, Y and 8, we found a significant 2-4 fold increase in particular numerical chromosomal abnormalities during treatment which were limited in persistence post-treatment. Additionally, pre-treatment Hodgkin`s disease patients showed elevations in some numerical chromosomal abnormalities when compared to a healthy reference group. In several men, the fraction of aneuploid sperm did not return to healthy reference group levels even after completion of therapy. These results show that elevated sperm aneuploidy occurs in germ cells of young cancer patients during chemotherapy and suggest caution to prevent conceptions during this period. The elevated sperm aneuploidy appears transient, but in some cases never returns to healthy reference group levels.

Robbins, W.A.; Cassel, M.J.; Wyrobek, A.J. [Lawrence Livermore National Lab., CA (United States)] [and others

1994-09-01

113

Chinese Connections  

ERIC Educational Resources Information Center

When L. Brooks Patterson, the executive of Oakland County, Michigan, publicly called for the county to become the first in America to teach Mandarin Chinese in every public school district, the Oxford Community Schools responded immediately. Over the past four years, the school district of 5,030 students in southeastern Michigan has elevated the…

Skilling, William C.

2012-01-01

114

Intrinsic inhibition of transcription factor E2A by HLH proteins ABF1 and Id2 mediates reprogramming of neoplastic B cells in Hodgkin lymphoma  

Microsoft Academic Search

B cell differentiation is controlled by a complex network of lineage-restricted transcription factors. How perturbations to this network alter B cell fate remains poorly understood. Here we show that classical Hodgkin lymphoma tumor cells, which originate from mature B cells, have lost the B cell phenotype as a result of aberrant expression of transcriptional regulators. The B cell–specific transcription factor

Martin Janz; Franziska Hummel; Michael Hummel; Brigitte Wollert-Wulf; Simone Lusatis; Ioannis Anagnostopoulos; Andreas Lietz; Mikael Sigvardsson; Franziska Jundt; Korinna Jöhrens; Kurt Bommert; Harald Stein; Bernd Dörken; Stephan Mathas

2005-01-01

115

Bilateral breast cancer after cured Hodgkin's disease  

Microsoft Academic Search

Three patients developed bilateral breast cancer at 10 to 24 years after mantle irradiation for locally or systemically advanced Hodgkin's disease (HD). Four of the six cancers in the three patients were detected only by mammography. Pathologically, five of the cancers were intraductal carcinomas (four with an invasive component) with one being a lobular carcinoma. Five of the six lesions

Norwood Anderson; Jacob Lokich

1990-01-01

116

MVPP chemotherapy regimen for advanced Hodgkin's disease  

Microsoft Academic Search

During January 1968 to December 1972, 133 patients with advanced Hodgkin's disease (HD) were admitted to hospital for combination chemotherapy with mustine, vinblastine, procarbazine, and prednisolone (MVPP regimen). Remission rates were 76% among 49 untreated patients and 90% among 42 patients who had relapsed after radiotherapy. The corresponding five-year survival rates were 65% and 86% respectively. Provided the observed yearly

S B Sutcliffe; P F M Wrigley; J Peto; T A Lister; A G Stansfeld; J M A Whitehouse; D Crowther; J S Malpas

1978-01-01

117

Chinese Geography through Chinese Cuisine  

ERIC Educational Resources Information Center

China has the world's largest population, now over 1.3 billion, but its land area (much of it high mountains or desert) is about the same as that of the United States, which has less than one-fourth as many people. So Chinese farmers have learned to use every inch of their fertile land intensively. Pressure on the land has required extremely…

Lipman, Jonathan

2010-01-01

118

What Are the Key Statistics for Non-Hodgkin Lymphoma in Children?  

MedlinePLUS

... Hodgkin lymphoma in children? What are the key statistics for non-Hodgkin lymphoma in children? Non-Hodgkin ... but is uncommon in children younger than 3. Statistics on survival can be found in the section “ ...

119

Clinical characteristics of 26 patients with primary extranodal Hodgkin lymphoma  

PubMed Central

Background: Most Hodgkin lymphoma (HL) patients present with disease in nodal regions. However, in a small subset, disease develops extranodal sites primarily, such as lung and liver. This study aims to identify the characteristics and outcomes of patients with primary extranodal HL. Methods: A retrospective analysis of patients with HL from 1998 to 2012 was enrolled. We selected 26 HL patients with primary extranodal involvement from 251 previously untreated HL patients. All data analyses were performed with SPSS software version 17.0 and GraphPad Prism 5. Results: We identified 26 patients with primary extranodal HL. Results in the series of young patients, male predominated. Pathologically, the major pathologic types were nodular sclerosis classical HL (NSCHL, 46.2%) and mixed cellularity classical HL (MCCHL, 38.5%). Thirteen patients had early stage (I or II stage). The most commonly primarily extranodal sites were the lung and the stomach and intestine, followed by the liver and bones. Fifteen of 26 received chemotherapy alone and 11 received combination therapy. Finally, primary extranodal HLs in our study have a favorable survival. Furthermore, there was no significant association between the international prognostic score (IPS) and survival in patients with extranodal HL. Conclusion: Our retrospective data in part reflect clinical characteristics of primary extranodal HL in China, and form the basis for further concerning researches. PMID:25197377

Ma, Jing; Wang, Yafei; Zhao, Haifeng; Liu, Su; li, Qian; Lin, Li; Yue, Yuanfang; Wang, Xiaofang; Zhao, Zhigang; Yu, Yong; Zhang, Yizhuo

2014-01-01

120

Chinese Dinosaurs  

NSDL National Science Digital Library

What's "Jurassic Park" in Mandarin? That isn't easy to say, but if you're interested in Chinese dinosaurs, then you will love the new online (and real) exhibit hosted by the Australian Museum in Sydney. A vast land containing many of the world's best-preserved dinosaur specimens, China offers remnants of many species not commonly available in Western exhibits. With lots to explore, the site features a readily accessible list of dinosaurs, each arranged under its Chinese-derived species name. Not like anything most of us have ever heard, many of the specimens look and seem familiar, at least as members of the dinosaur family. While generally well-executed, particularly worthy of note is the site's presentation of China's celebrated feathered dinosaurs, Caudipteryx zoui and Protarchaeopteryx, two curious figures believed to represent part of the great reptilian leap from land to air.

2002-01-01

121

Chinese Culture and Leadership.  

ERIC Educational Resources Information Center

Describes essential characteristics of Chinese philosophical tradition; Discusses Western perspectives on value leadership in education, particularly moral leadership. Discuses moral leadership from a Chinese philosophical perspective, especially Confucianism. Draws implications for using Chinese cultural and philosophical traditions to develop…

Wong, Kam-Cheung

2001-01-01

122

Role of brentuximab vedotin in the treatment of relapsed or refractory Hodgkin lymphoma.  

PubMed

Brentuximab vedotin (BV) is an antibody-drug conjugate that targets CD30-positive malignancies via an anti-CD30 monoclonal antibody linked to monomethyl auristatin E, a microtubule-disrupting agent, by a protease-cleavable linker. BV has received accelerated approval from the US Food and Drug Administration for the treatment of classical Hodgkin lymphoma that has relapsed either after autologous stem cell transplantation (ASCT) or after two lines of combination chemotherapy in patients ineligible for ASCT, and in systemic anaplastic large cell lymphoma after failure of at least one line of multiagent chemotherapy. Phase I studies in CD30-positive lymphomas have determined the maximum tolerated dose to be 1.8 mg/kg intravenously every 21 days. In relapsed/refractory Hodgkin lymphoma, a pivotal Phase II study of single-agent BV showed an overall response rate of 75%, with 34% complete responses and a median remission duration of 20 months for complete responders. BV has a modest toxicity profile, with peripheral neuropathy as one of the most clinically significant side effects, and this is largely reversible. Therefore, BV is the treatment of choice for patients with relapsed/refractory Hodgkin lymphoma after ASCT or two standard regimens. Ongoing trials are evaluating the role of BV as salvage therapy prior to ASCT and for maintenance after ASCT for patients with relapsed/refractory disease. PMID:24672256

Siddiqi, Tanya; Thomas, Sandra H; Chen, Robert

2014-01-01

123

Role of brentuximab vedotin in the treatment of relapsed or refractory Hodgkin lymphoma  

PubMed Central

Brentuximab vedotin (BV) is an antibody-drug conjugate that targets CD30-positive malignancies via an anti-CD30 monoclonal antibody linked to monomethyl auristatin E, a microtubule-disrupting agent, by a protease-cleavable linker. BV has received accelerated approval from the US Food and Drug Administration for the treatment of classical Hodgkin lymphoma that has relapsed either after autologous stem cell transplantation (ASCT) or after two lines of combination chemotherapy in patients ineligible for ASCT, and in systemic anaplastic large cell lymphoma after failure of at least one line of multiagent chemotherapy. Phase I studies in CD30-positive lymphomas have determined the maximum tolerated dose to be 1.8 mg/kg intravenously every 21 days. In relapsed/refractory Hodgkin lymphoma, a pivotal Phase II study of single-agent BV showed an overall response rate of 75%, with 34% complete responses and a median remission duration of 20 months for complete responders. BV has a modest toxicity profile, with peripheral neuropathy as one of the most clinically significant side effects, and this is largely reversible. Therefore, BV is the treatment of choice for patients with relapsed/refractory Hodgkin lymphoma after ASCT or two standard regimens. Ongoing trials are evaluating the role of BV as salvage therapy prior to ASCT and for maintenance after ASCT for patients with relapsed/refractory disease. PMID:24672256

Siddiqi, Tanya; Thomas, Sandra H; Chen, Robert

2014-01-01

124

Brentuximab vedotin for relapsed or refractory Hodgkin lymphoma: experience in Turkey.  

PubMed

Current treatment modalities can cure up to 70-80 % of patients with classical Hodgkin lymphoma. Approximately, 20-30 % of patients require further treatment options. Brentuximab vedotin has been approved for the treatment of relapsed and refractory Hodgkin lymphoma. In the present study, we report the experience with brentuximab vedotin as single agent in 58 patients with relapsed or refractory Hodgkin lymphoma. The objective response rate was 63.5 % with 13 complete responders (26.5 %) among 49 patients evaluated at the early phase of treatment (2-5 cycles). Upon treatment prolongation (?6 cycles), 37 patients achieved a final objective response rate of 32.4 % with 21.6 % of complete and 10.8 % of partial response. Overall survival at 12 months was 70.6 %, and progression-free survival at 12 months was 32.8 %. Median overall survival could not be reached and median progression-free survival was 7 months. While the median duration of response was 9 months in the whole cohort, it was 11.5 months in the complete responders. Complete response rates in patients treated with >3 chemotherapy regimens before brentuximab vedotin were significantly lower (p?=?0.016). Fourteen patients were subsequently transplanted. In conclusion, brentuximab vedotin provided a bridge to transplantation in approximately one quarter of the patients. The declining response rates during the course of treatment suggest that transplantation should be implemented early during brentuximab vedotin treatment. PMID:25231929

Salihoglu, A; Elverdi, T; Karadogan, I; Paydas, S; Ozdemir, E; Erdem, G; Karadurmus, N; Akyol, G; Kaynar, L; Yegin, Za; Sucak, G; Ozkocaman, V; Topcuoglu, P; Ozcan, M; Birtas, E; Goker, H; Baslar, Z; Ferhanoglu, B

2015-03-01

125

Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant.  

PubMed

Primary cutaneous follicle center lymphoma (PCFCL) is the most frequent cutaneous B-cell lymphoma. A 62-year-old man presented with a solitary indolent subcutaneous nodule for 3 years duration, without other abnormalities. Histological examination showed lymphoproliferation with a nodular growth pattern characterized by fibrous collagen bands surrounding nodules. The nodules were composed of medium-sized centrocytes admixed with many large multilobulated and lacunar cells without eosinophils or granulomatous aspect. Hodgkin-like cells were CD30+, CD15+, PAX5+, OCT2+, BOB1+, MUM1+, Ki67+, Bcl6+ and focally CD20+ and EMA-, CD79a-, Bcl2- and CD10-. The medium-sized cells were CD20+, CD79a+, Bcl2+, Bcl6+ and CD10+, enmeshed in a network of CD21-positive follicular dendritic cells. Epstein-Barr virus detection was negative. Interphase fluorescence in situ hybridization showed the absence of BCL2 or BCL6 rearrangement. In such a case, the presence of Hodgkin-like cells intermixed with the tumor population may result in a pitfall diagnosis of classical Hodgkin lymphoma (CHL). Differential diagnoses to be ruled out are secondary or primary skin localization of rather CHL, or systemic follicular lymphoma. Several clinical, radiological, histological, immunohistochemical and molecular arguments indicated the diagnosis of PCFCL. To our knowledge, this is the first report of PCFCL with Hodgkin-like cells. PMID:25099172

Marie, Dilly; Houda, Ben-Rejeb; Béatrice, Vergier; Matthieu, Feldis; Louis, Toty; Olivier, Nohra; Marie, Beylot-Barry; Audrey, Gros; Jean-Philippe, Merlio; Marie, Parrens

2014-10-01

126

Non-Hodgkin Lymphoma (NHL) in Pakistan.  

PubMed

Lymphomas are classified as Hodgkin's and Non-Hodgkin's lymphomas (HL; NHL); NHL being further sub-divided into B, T and Null cell categories on the basis of WHO classification. With a few exceptions worldwide, B-NHL are more common, accounting approximately 80-85% of all cases of NHL compared to T-NHL, which accounts for about 10-15% of all NHL cases. The incidence of NHL has shown a steady increase and attention is being focused on the possible causes of this increase. Epidemiologic studies indicate that environmental factors do play a role in the causation of NHL, such as drugs, pesticides, solvents, hair dyes, viruses (EBV, HTLV-1, Hepatitic C and HIV) and Helicobacter pylori. Hence many different environmental factors of risk acting on large segments of the population can contribute for increase of NHL. PMID:24551760

Pervez, Shahid

2012-01-01

127

Treatment of refractory Hodgkin’s disease with an anti-CD16\\/CD30 bispecific antibody  

Microsoft Academic Search

A group of 15 patients with refractory Hodgkin?s disease were treated in a phase I\\/II trial with the natural-killer (NK)-cell-activating\\u000a bispecific monoclonal antibody HRS-3\\/A9, which is directed against the Fc? receptor III (CD16 antigen) and the Hodgkin’s associated\\u000a CD30 antigen. The antibody was given four times every 3?–?4 days, starting with 1 mg\\/m2. The treatment was well tolerated and the

Cristoph Renner; Frank Hartmann; Michael Pfreundschuh

1997-01-01

128

Radiation-induced Spinal Cord Glioma Subsequent to Treatment of Hodgkin’s Disease: Case Report and Review  

Microsoft Academic Search

Summary  Radiation-induced neoplasms of the central nervous system generally present as meningioma or sarcoma. Spinal cord glioma after\\u000a radiation therapy is rare and half of the cases documented occurred after treatment of Hodgkin’s disease.\\u000a \\u000a A 39-year-old male presented with a 1-month history of gradually worsening neck ache and paraparesis. The patient had been\\u000a treated for stage IB Hodgkin’s disease 9 years previously

Laurent Riffaud; Marc Bernard; Thierry Lesimple; Xavier Morandi

2006-01-01

129

Late cardiotoxicity after treatment for Hodgkin lymphoma  

Microsoft Academic Search

We assessed cardiovascular disease (CVD) incidence in 1474 survivors of Hodgkin lymphoma (HL) younger than 41 years at treatment (1965-1995). Multivariable Cox regression and competing risk analyses were used to quantify treatment effects on CVD risk. After a median follow-up of 18.7 years, risks of myocardial infarction (MI) and congestive heart failure (CHF) were strongly increased compared with the general

Berthe M. P. Aleman; Belt-Dusebout van den A. W; Bruin de M. L; Veer van't M. B; Margreet H. A. Baaijens; Boer de J. P; Augustinus A. M. Hart; Willem J. Klokman; Marianne A. Kuenen; Gabey M. Ouwens; Harry Bartelink; Leeuwen van F. E

2007-01-01

130

Chinese Calendar and Chinese Telegraphic Code.  

ERIC Educational Resources Information Center

This manual contains: (1) Chinese calendars for the hundred years from 1881 to 1980; and (2) the Chinese telegraphic code. Each page in Part One presents the calendar for each year in both Chinese and English. There are 97 charts in Part Two representing the telegraphic code. (AMH)

Defense Language Inst., Monterey, CA.

131

Hodgkin's lymphoma preceded by haemophagocytic lymphohistiocytosis.  

PubMed

A 71-year-old woman was admitted because of persistent fever for 2 weeks. A diagnosis of haemophagocytic lymphohistiocytosis (HLH) was made on the basis of persistent high fever, pancytopoenia, hyperferritinaemia, increased soluble interleukin-2 receptor (sIL-2R) levels and histiocytosis and hemophagocytosis in the bone marrow. CT showed neither infection nor lymphadenopathy. After administration of prednisolone, haematological findings improved and the fever resolved; however, the patient developed persistent fever after 6 months. In addition, levels of lactate dehydrogenase and sIL-2R increased again. CT scans revealed diffuse lymphadenopathy, and Hodgkin's lymphoma was diagnosed by lymph node biopsy. Progression of pancytopenia was observed, and bone marrow examination showed a relapse of HLH. After six courses of chemotherapy were given for Hodgkin's lymphoma, complete remission was achieved with no evidence of pancytopenia. Hodgkin's lymphoma may be the underlying cause in HLH cases of unknown aetiology. Hence, the clinical course should be carefully monitored even in the absence of lymphadenopathy. PMID:23761512

Morita, Yoshinori; Kenzaka, Tsuneaki; Yoshimoto, Hideyuki; Ohno, Nobuhito

2013-01-01

132

Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease  

ClinicalTrials.gov

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

2013-01-22

133

The Evolving Role of Radiotherapy in Early Stage Hodgkin’s Lymphoma  

PubMed Central

Radiation therapy has a key role in the combined modality treatment of early-stage Hodgkin’s Lymphoma (HL). Nevertheless, late toxicity still remains an issue. A modern approach in HL radiotherapy includes lower doses and smaller fields, together with the implementation of sophisticated and dedicated delivery techniques. Aim of the present review is to discuss the current role of radiotherapy and its potential future developments, with a focus on major clinical trials, technological advances and their repercussion in the clinical management of HL patients. PMID:24959332

Ricardi, Umberto; Filippi, Andrea Riccardo; Piva, Cristina; Franco, Pierfrancesco

2014-01-01

134

Short Communication Risk of NonHodgkin Lymphoma Associated with  

E-print Network

. (Cancer Epidemiol Biomarkers Prev 2005;14(12):2999­3003) Introduction Non­Hodgkin lymphoma (NHL Institute of Cancer Research and Royal Marsden NHS Trust, Department of Haemato-Oncology, Surrey, United in the pathogenesis of lymphoproliferative dis- orders such as non­Hodgkin lymphoma (NHL). DNA synthesis

California at Berkeley, University of

135

Unusual thoracic radiographic findings in children treated for Hodgkin's disease  

Microsoft Academic Search

Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients,

M. S. Jochelson; N. J. Tarbell; H. J. Weinstein

1986-01-01

136

Identification of stromal proteins overexpressed in nodular sclerosis Hodgkin lymphoma  

PubMed Central

Hodgkin lymphoma (HL) represents a category of lymphoid neoplasms with unique features, notably the usual scarcity of tumour cells in involved tissues. The most common subtype of classical HL, nodular sclerosis HL, characteristically comprises abundant fibrous tissue stroma. Little information is available about the protein composition of the stromal environment from HL. Moreover, the identification of valid protein targets, specifically and abundantly expressed in HL, would be of utmost importance for targeted therapies and imaging, yet the biomarkers must necessarily be accessible from the bloodstream. To characterize HL stroma and to identify potentially accessible proteins, we used a chemical proteomic approach, consisting in the labelling of accessible proteins and their subsequent purification and identification by mass spectrometry. We performed an analysis of potentially accessible proteins in lymph node biopsies from HL and reactive lymphoid tissues, and in total, more than 1400 proteins were identified in 7 samples. We have identified several extracellular matrix proteins overexpressed in HL, such as versican, fibulin-1, periostin, and other proteins such as S100-A8. These proteins were validated by immunohistochemistry on a larger series of biopsy samples, and bear the potential to become targets for antibody-based anti-cancer therapies. PMID:21975223

2011-01-01

137

Non-Hodgkin’s Lymphoma in Buccal Vestibule -Case Report  

PubMed Central

Lymphomas are malignant neoplasms arising from lymphocytes B cell or T cell that affects mainly lymph nodes, spleen and other non hematopoietic tissues. They are classified as Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin’s lymphomas and frequently involves extranodal sites. In the oral soft tissues lesions can occur as hard and diffuse tumors involving oral vestibule, gums and posterior region of the hard palate. Most lymphomas, including DLBL arise from B cells are characterized by diffuse population of large cells with cleaved or non cleaved oval nuclei. Both histopathlogical and immunohistochemical (IHC) analysis were strongly advisable for proper management and prognosis. We hereby report a rare case of Diffuse large B-cell variant of non-Hodgkin’s lymphoma in a male patient of age 50yrs in left upper buccal vestibule. PMID:25302245

G, Sreenath; Reddy Y, Raghavendra; Prakash A, Ravi; T R, Swathi

2014-01-01

138

CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia

2014-10-31

139

Chinese Posters  

NSDL National Science Digital Library

This fascinating site, brought to fruition by Dutch Sinologist Stefan R. Landsberger, seeks to provide âÂÂa visual chronicle of the history of modern Chinaâ through the exhibition of over 5,000 PeopleâÂÂs Republic of China propaganda posters. Viewers may want to start with the Gallery of Chinese Propaganda Posters â an overview of 200 highlights from the collection. A visit to Our Most Visited Theme Pages and Recently Added Posters also pays intellectual dividends (Iron Women and Foxy Ladies is an especially great find). But perhaps the true gem of the site is the 200 theme presentations found under the Themes link, where readers can explore categories such as Before the PeopleâÂÂs Republic, Campaigns â 1949-1965, Models and Martyrs, and Mao Zedong.

140

Classic Problems  

NSDL National Science Digital Library

Classic problems from the Ask Dr. Math FAQ (Frequently Asked Questions) files, including: age word problems, birthday probability, boy or girl?, camel and bananas, coin problems, doubling pennies, grazing animals, liars and truthtellers, the missing dollar, Monty Hall (three doors), three houses three utilities, the Tower of Hanoi, two trains, two trains and a fly, and working together.

Forum, Math; Math Forum; Ask Dr. Math FAQ

2002-01-01

141

Fatal measles pneumonitis during Hodgkin's lymphoma.  

PubMed

The treatment of measles pneumonitis in immunocompromised adults is not established. We describe a patient with Hodgkin's lymphoma who developed acute pneumonia during a measles infection. On day 13, intravenous ribavirin and immunoglobulins were administrated. On day 18, the patient developed acute respiratory failure. An examination of transbronchial pulmonary biopsies showed Warthin-Finkeldey giant cells that are pathognomonic of measles pneumonitis. The patient died despite aggressive supportive care. Our case and a review of literature show that measles pneumonitis is routinely fatal in patients with cancer. We suggest that antiviral drugs should be considered as soon as the diagnosis has been established. PMID:24105383

Wyplosz, Benjamin; Lafarge, Marion; Escaut, Lélia; Stern, Jean-Baptiste

2013-01-01

142

Combination chemoradiotherapy in early Hodgkin lymphoma.  

PubMed

Combination chemoradiotherapy achieves excellent results for the treatment of localized Hodgkin lymphoma. However, late toxic effects occur, mostly related to the radiotherapy administered after the standard adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy. The most serious sequelae are radiation-induced secondary cancers. Reducing radiotherapy has not yet prevented late malignancies. However, when radiotherapy was omitted, tumor control was inferior, with more relapses necessitating rescue treatment including high-dose chemotherapy with stem cell support. Early fluorodeoxyglucose positron emission tomography performed after a few cycles of ABVD is evaluated in several randomized trials to identify patients who might be safely treated with chemotherapy alone. PMID:24287066

André, Marc P E

2014-02-01

143

Happy (Chinese) New Year!  

ERIC Educational Resources Information Center

Suggestions are made for a classroom celebration of Chinese New Year, including discussion of the Chinese calendar and customs, a short list of appropriate children's stories, and food ideas, including a recipe for fortune cookies. (SJL)

Johnson, Georgia G.

1979-01-01

144

Morphologic changes in the thyroid after irradiation for Hodgkin's and non-Hodgkin's lymphoma  

SciTech Connect

Four cases of thyroidectomy for suspected thyroid carcinoma after previous irradiation for Hodgkin's or non-Hodgkin's lymphoma are reviewed. The patients ranged in age from 18 to 33 years at the time of thyroid surgery with an average latency period of 12 years (range, 8-20 years) from radiation therapy to thyroidectomy. All patients had a clinically palpable thyroid nodule, and pathologically showed a pattern of multiple adenomatous nodules with cytologic atypia. The microscopic changes were sufficiently striking to cause the primary pathologist to request consultation to rule out thyroid carcinoma in each case. Fine-needle aspiration was performed in one case and suggested a thyroid neoplasm. The pathologic findings are reviewed and distinction of this lesion from thyroid carcinoma is discussed.

Carr, R.F.; LiVolsi, V.A.

1989-08-15

145

Hodgkin’s lymphoma coexisting with liver failure secondary to acute on chronic hepatitis B  

PubMed Central

Acute on chronic liver failure (ACLF) is rarely the initial manifestation of a malignant process or precipitated by the initiation of anti-viral treatment with a nucleoside or nucleotide agent. We report an unusual case of ACLF temporally associated with initiation of Entecavir for treatment of chronic hepatitis B. Early Hodgkin’s lymphoma (HL) was unmasked with initiation of the anti-viral treatment which may have exacerbated ACLF. To the best of our knowledge, this has not been described in the literature. In reviewing our patients clinical course and liver autopsy, he developed a severe acute exacerbation of his chronic hepatitis B virus coinciding with the institution of antiviral therapy and the underlying HL perhaps modulating the overall degree of hepatic injury. PMID:24303460

Palta, Renee; McClune, Amy; Esrason, Karl

2013-01-01

146

Classical isometrodynamics  

SciTech Connect

A generalization of non-Abelian gauge theories of compact Lie groups is developed by gauging the noncompact group of volume-preserving diffeomorphisms of a D-dimensional space R{sup D}. This group is represented on the space of fields defined on M{sup 4}xR{sup D}. As usual the gauging requires the introduction of a covariant derivative, a gauge field, and a field strength operator. An invariant and minimal gauge field Lagrangian is derived. The classical field dynamics and the conservation laws of the new gauge theory are developed. Finally, the theory's Hamiltonian in the axial gauge and its Hamiltonian field dynamics are derived.

Wiesendanger, C

2009-07-15

147

Chinese Business Law Postgraduate  

E-print Network

development in China · Principles of Chinese law · Legal institutional framework · Dispute settlement Chinese) · Consumer protection · Due diligence · Product quality legislation · Foreign trade regulations · Entry modes law 4 2 · Customs law & Regulations · Foreign trade law Chinese environmental law 3 2 · Environmental

Einmahl, Uwe

148

Chinese Folktales for Children.  

ERIC Educational Resources Information Center

This bilingual text contains ten traditional Chinese folktales which have been rewritten for children. Each story deals with interpersonal relationships and/or stresses the Chinese way of life. Each page of text is given first in English and then in Chinese and is illustrated with a full-page drawing. The titles of the folktales are: (1) "One…

Kwok, Irene

149

Non-Hodgkin's Lymphoma in Buccal Vestibule -Case Report.  

PubMed

Lymphomas are malignant neoplasms arising from lymphocytes B cell or T cell that affects mainly lymph nodes, spleen and other non hematopoietic tissues. They are classified as Hodgkin's lymphoma (HL) and non-Hodgkin's lymphoma (NHL). Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin's lymphomas and frequently involves extranodal sites. In the oral soft tissues lesions can occur as hard and diffuse tumors involving oral vestibule, gums and posterior region of the hard palate. Most lymphomas, including DLBL arise from B cells are characterized by diffuse population of large cells with cleaved or non cleaved oval nuclei. Both histopathlogical and immunohistochemical (IHC) analysis were strongly advisable for proper management and prognosis. We hereby report a rare case of Diffuse large B-cell variant of non-Hodgkin's lymphoma in a male patient of age 50yrs in left upper buccal vestibule. PMID:25302245

Reddy, Indira; G, Sreenath; Reddy Y, Raghavendra; Prakash A, Ravi; T R, Swathi

2014-08-01

150

E-rosette inhibiting substance in Hodgkin's disease spleen extracts.  

PubMed Central

Patients with Hodgkin's disease often manifest impairment of cell-mediated immune responses in both in vivo and in vitro tests, as well as a markedly decreased percentage of E rosette-forming (T) lymphocytes in the peripheral blood. This report describes the inhibition of E-rosette formation by normal peripheral blood lymphocytes after incubation with extracts prepared from the spleens of patients with Hodgkin's disease. Such extracts also depressed E-rosette formation by the peripheral blood lymphocytes of patients with Hodgkin's disease after those cells had been restored to normal function by prior incubation in foetal calf serum. Similarly prepared extracts from the spleens of normal donors had no immunodepressive effect. The E-rosette inhibitory substance in the Hodgkin's disease spleen extracts was found to be a complex containing beta-lipoprotein, C-reactive protein, and C1q. PMID:201408

Bieber, M M; Fuks, Z; Kaplan, H S

1977-01-01

151

Prelymphomatous presentation of T-cell non-Hodgkin lymphomas  

Microsoft Academic Search

We report a retrospective study of 11 patients suffering from T-cell non-Hodgkin lymphomas preceded by immunological disorders including two chronic granulomatous diseases, one midline granuloma, four autoimmune hematologic disorders, one hypereosinophilic syndrome, two chronic lymphadenopathies, and one chronic angioedema. In the follow-up of these 11 patients, T-cell non-Hodgkin lymphomas were diagnosed. Even if we cannot exclude a fortuitous association, we

Brigitte Granel; Réda Bouabdallah; Jacques Serratrice; Laure Swiader; Véronique Veit; Nicole Horschowski; Luc Xerri; Patrick Disdier; Pierre-Jean Weiller

2001-01-01

152

Tumeur phyllode maligne du sein après maladie de Hodgkin  

PubMed Central

Le traitement par radiochimiothérapie de la maladie d'Hodgkin a permis une amélioration spectaculaire de son pronostic. Cependant, les néoplasies secondaires à ce type de traitement sont fréquentes et représentent un sérieux problème. Nous rapportons un cas de tumeur phyllode maligne du sein, diagnostiquée 15 ans après le traitement d'une maladie d'Hodgkin, en discutant ses différentes particularités diagnostiques et thérapeutiques, ainsi que les stratégies de suivi et de surveillance optimales. PMID:23396310

Mohamed, El Hfid; Loubna, Mezouar; Tijani, El Harroudi

2012-01-01

153

Bilateral adrenal non-Hodgkin's lymphoma with adrenal insufficiency  

PubMed Central

A 74 year old women presented with lethargy and weight loss and was found to have profound adrenal insufficiency and bilateral adrenal mass lesions. Histological examination revealed non-Hodgkin's lymphoma. There was no evidence of lymphoma outside the adrenal glands. Isolated bilateral adrenal masses may rarely be due to primary adrenal non-Hodgkin's lymphoma, which is often associated with adrenal insufficiency.???Keywords: lymphoma; adrenal insufficiency PMID:10908383

Ellis, R; Read, D

2000-01-01

154

Classics Unveiled  

NSDL National Science Digital Library

Classics Unveiled was developed by Neil Jenkins, Sumair Mirza and Jason Tang as a way to teach the web-browsing public about the various aspects of the ancient world, ranging from the massive world of Greek and Roman mythology, Roman history, Roman culture, and the Latin language and its pervasive influence on English. The site is divided into four primary areas, and visitors may opt to browse through any of them and their accompanying features, which include primary extended essays and informative games and quizzes. In Rome Exposed for example, users will learn about Roman residences, entertainment, attire, cuisine, and several other aspects of Roman culture and mores. In MythNET visitors can learn about the twelve Olympian gods, read about the Trojan War, and explore genealogical charts that trace the various relationships between the pantheon of Rome and Greece.

Jenkins, Neil; Mirza, Sumair; Tang, Jason

155

PD-1 Blockade with Nivolumab in Relapsed or Refractory Hodgkin's Lymphoma.  

PubMed

Background Preclinical studies suggest that Reed-Sternberg cells exploit the programmed death 1 (PD-1) pathway to evade immune detection. In classic Hodgkin's lymphoma, alterations in chromosome 9p24.1 increase the abundance of the PD-1 ligands, PD-L1 and PD-L2, and promote their induction through Janus kinase (JAK)-signal transducer and activator of transcription (STAT) signaling. We hypothesized that nivolumab, a PD-1-blocking antibody, could inhibit tumor immune evasion in patients with relapsed or refractory Hodgkin's lymphoma. Methods In this ongoing study, 23 patients with relapsed or refractory Hodgkin's lymphoma that had already been heavily treated received nivolumab (at a dose of 3 mg per kilogram of body weight) every 2 weeks until they had a complete response, tumor progression, or excessive toxic effects. Study objectives were measurement of safety and efficacy and assessment of the PDL1 and PDL2 (also called CD274 and PDCD1LG2, respectively) loci and PD-L1 and PD-L2 protein expression. Results Of the 23 study patients, 78% were enrolled in the study after a relapse following autologous stem-cell transplantation and 78% after a relapse following the receipt of brentuximab vedotin. Drug-related adverse events of any grade and of grade 3 occurred in 78% and 22% of patients, respectively. An objective response was reported in 20 patients (87%), including 17% with a complete response and 70% with a partial response; the remaining 3 patients (13%) had stable disease. The rate of progression-free survival at 24 weeks was 86%; 11 patients were continuing to participate in the study. Reasons for discontinuation included stem-cell transplantation (in 6 patients), disease progression (in 4 patients), and drug toxicity (in 2 patients). Analyses of pretreatment tumor specimens from 10 patients revealed copy-number gains in PDL1 and PDL2 and increased expression of these ligands. Reed-Sternberg cells showed nuclear positivity of phosphorylated STAT3, indicative of active JAK-STAT signaling. Conclusions Nivolumab had substantial therapeutic activity and an acceptable safety profile in patients with previously heavily treated relapsed or refractory Hodgkin's lymphoma. (Funded by Bristol-Myers Squibb and others; ClinicalTrials.gov number, NCT01592370 .). PMID:25482239

Ansell, Stephen M; Lesokhin, Alexander M; Borrello, Ivan; Halwani, Ahmad; Scott, Emma C; Gutierrez, Martin; Schuster, Stephen J; Millenson, Michael M; Cattry, Deepika; Freeman, Gordon J; Rodig, Scott J; Chapuy, Bjoern; Ligon, Azra H; Zhu, Lili; Grosso, Joseph F; Kim, Su Young; Timmerman, John M; Shipp, Margaret A; Armand, Philippe

2014-12-01

156

[The impact of the study of contemporary and Confucian comments on the classic Neijing (Internal Classic) and its commentary and subcommentary].  

PubMed

The argumentation between the contemporary and old Confucian classics schools had a profound and lasting impact on the Traditional Chinese Academy, so as to evolve into two kinds of attitude towards the scholarship which influenced TCM which was based on traditional Chinese culture. These impacts reflected in the following three aspects: first, the differences between the words of different versions of Neijing (Internal Classic); second, the formation of some theories of Neijing (Internal Classic) such as the attachment of five zang-organs and five phases; third, the annotated methods for (Neijing (Internal Classic) of the physicians of past generations. PMID:20973276

Zhou, Qi; Liu, Chang-hua

2010-03-01

157

Clinical Significance of Soluble CD30 Antigen in the Sera of Patients With Untreated Hodgkin's Disease  

Microsoft Academic Search

The soluble form of the CD30 antigen (sCD30). an 88-Kd glycoprotein that is released by Hodgkin's-derived cell lines in vitro, can be detected in patients with Hodgkin's lym- phoma, adult (HTLV-1') T-cell leukemia, rare cases of non- Hodgkin's lymphoma, and acute infectious mononucleosis (anti-EBV-IgM'). In a prospective study of 90 consecutive untreated patients with newly diagnosed Hodgkin's disease who were

Angela Gause; Christoph Pohl; Astrid Tschiersch; Ligia Da Costa; Wolfram Jung; Volker Diehl; Dirk Hasenclever; Michael Pfreundschuh

158

Prolonged hemophagocytic lymphohistiocytosis syndrome as an initial presentation of Hodgkin lymphoma: a case report  

PubMed Central

Introduction Hemophagocytic lymphohistiocytosis is an immune-mediated syndrome that typically has a rapidly progressive course that can result in pancytopenia, coagulopathy, multi-system organ failure and death. Case presentation A 57-year-old Caucasian woman was referred in fulminant hemophagocytic lymphohistiocytosis, with fever, pancytopenia, splenomegaly, mental status changes and respiratory failure. She was found to have stage IV classical Hodgkin lymphoma, in addition to Epstein-Barr virus and cytomegalovirus viremia. Her presentation was preceded by a 3-year prodrome consisting of cytopenia and fever that were partially controlled by steroids and azathioprine. Conclusion Fulminant hemophagocytic lymphohistiocytosis may follow a prodromal phase that possesses features suggestive of a chronic form of hemophagocytic lymphohistiocytosis, but which may also resemble immune cytopenias of other causes. A diagnosis of hemophagocytic lymphohistiocytosis should be considered in the setting of chronic pancytopenia. PMID:19055804

Chan, Kathryn; Behling, Eric; Strayer, David S; Kocher, William S; Dessain, Scott K

2008-01-01

159

Peony transplanted: Pai Hsien-yung and the preservation of Chinese Kunqu   

E-print Network

This dissertation examines the preservation of Chinese kunqu, one of China’s indigenous operatic genres, in recent years with a special focus on renowned writer Pai Hsien-yung’s new adaptation of classic kunqu play The ...

Wei, Zhou

2011-11-22

160

Learn Chinese Characters  

NSDL National Science Digital Library

Zhongwen.com is a valuable online resource for individuals just beginning to learn Chinese, as well as those who want to learn more. The site contains the complete on line text of "Chinese Character: A Genealogy and Dictionary". All the Chinese characters are hyperlinked so that users of the site can quickly decipher new and unfamiliar characters in English. Additionally, the site has readings about Chinese culture written in Chinese such as the "Art of War" and "Mao Sayings". Finally, for those who may just have basic questions about the Chinese language there is a frequently asked questions section that addresses common questions such as "Why are characters so complicated?" and "Are they pictures?"

Harbaugh, Rick

2007-02-04

161

Incidence of non-Hodgkin's lymphoma in patients treated for Hodgkin's disease.  

PubMed

The purpose of this study was to evaluate the incidence of non-Hodgkin's lymphoma (NHL) as a second tumor in patients treated for Hodgkin's disease (HD), as well as to establish the role of different variables in its appearance. Between January 1973 and June 1988, 101 patients with HD were treated according to the stage, with chemotherapy and/or radiotherapy. Complete remission was obtained in 87 patients. Five patients developed secondary NHL between the 77th and 124th month of complete remission. The median follow up was 73 months (range 3-227 months). The incidence of second NHL in our series was, 0%, 4.6% (CI 0-11%) and 17% (CI 4-32%) at 5, 10 and 15 years respectively. Cox's stepwise regression analysis performed with all initial and treatment covariates (sex, age, splenectomy, histology, stage and treatment modality) showed that the only statistically significant variable was the treatment received (p < 0.01). Cumulative incidence of NHL at 15 years, ranged from 0% for patients treated with radiotherapy or chemotherapy alone to 39.6% for those who received combined therapy (p = 0.002). We can conclude that the use of chemotherapy plus radiotherapy for treatment of HD increases the risk for the development of second NHL. PMID:8180608

Prósper, F; Robledo, C; Cuesta, B; Rifón, J; Borbolla, J R; Pardo, J; Rocha, E

1994-02-01

162

Management of coexisting Hodgkin's disease and pregnancy  

SciTech Connect

The management of pregnant women with active Hodgkin's disease (H.D.) should be individualized depending on the stage, the presence of infradiaphragmatic involvement, and age of gestation. Seventeen women aged 16-31 years with coexisting H.D. and pregnancy were followed between 1969 and 1982. H.D. was diagnosed during pregnancy in 15 patients and two became pregnant while on treatment. Seven women whose pregnancies were allowed to proceed uninterrupted were irradiated to supradiaphragmatic sites to doses of 1500-2000 rad during the second or third trimester; all had full term spontaneous normal deliveries and normal infants. Fetal doses ranged from 2-50 rad. Two patients treated with Vinblastine throughout three pregnancies delivered normal full term infants. Pregnancy was interrupted in six patients at 6-20 weeks of gestation for various reasons. In spite of several months delay in initiation of definitive therapy, the outcome of H.D. was not adversely affected in the majority of uninterrupted pregnancies as evidenced by long term disease-free survivals of 6-11 years in four of seven patients who were irradiated; the children now aged 6-11 years are also alive and reported normal.

Nisce, L.Z.; Tome, M.A.; He, S.; Lee, B.J. III; Kutcher, G.J.

1986-04-01

163

Radioimmunotherapy for Non-Hodgkin’s Lymphoma  

PubMed Central

Non-Hodgkin’s lymphoma (NHL) is the most common hematological malignancy in the United States with a rapidly increasing incidence. Most follicular NHL is indolent but incurable, whereas the more aggressive varieties do respond to therapy. Most patients with follicular NHL who transform to an aggressive NHL are very difficult to treat successfully. Treatment options have included chemotherapy, radiation, immunotherapy with monoclonal antibodies, alone or in combination, and hematopoietic stem cell transplantation. The efficacy of monoclonal antibodies is augmented when they are combined with a radioisotope like iodine-131 or yttrium-90. There have been a number of studies done in recent years studying the efficacy of this form of therapy, i.e., radioimmunotherapy (RIT) in patients with NHL. This review attempts to integrate the information from the various clinical trials done using RIT in patients with relapsed/refractory or newly diagnosed NHL and in hematopoietic stem cell transplantation. It also includes updates on the use of RIT in elderly patients and in patients with significant bone marrow involvement among other recent advances made in this field. PMID:16160070

Rao, Arati V.; Akabani, Gamal; Rizzieri, David A.

2005-01-01

164

Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-Cell Lymphoma; AIDS-Related Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Post-Transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2015-02-18

165

Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-Cell Lymphoma; AIDS-Related Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Post-Transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2014-12-19

166

Hodgkin's Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child.  

PubMed

Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin's lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin's lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin's lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children. PMID:25328742

Benmiloud, Sarra; Hbibi, Mohamed; Chaouki, Sana; Abourazzak, Sana; Hida, Moustapha

2014-01-01

167

Hodgkin's Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child  

PubMed Central

Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin's lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin's lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin's lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children. PMID:25328742

Benmiloud, Sarra; Hbibi, Mohamed; Chaouki, Sana; Abourazzak, Sana; Hida, Moustapha

2014-01-01

168

Female reproductive potential after treatment for Hodgkin's disease  

SciTech Connect

The probability of maintaining ovarian function, becoming pregnant, and delivering a normal child is important to young women anticipating successful therapy for Hodgkin's disease. In this study, reproductive function was retrospectively examined in 103 women 40 years old or younger who had undergone treatment for Hodgkin's disease with total-lymphoid irradiation (TLI) alone, combination chemotherapy, or combined TLI and chemotherapy. Infertility was directly related to gonadal exposure to therapy and to age at treatment. Twenty women became pregnant after receiving total-nodal irradiation or combination chemotherapy or both. No fetal wastage occurred, and no birth defects were seen in the 24 infants born to these women. Even after intensive treatment programs, women successfully treated for Hodgkin's disease have become pregnant and delivered phenotypically normal children.

Horning, S.J.; Hoppe, R.T.; Kaplan, H.S.; Rosenberg, S.A.

1981-06-01

169

Hodgkin's lymphoma presenting with heart failure: a case report  

PubMed Central

Introduction Cardiac involvement in malignant lymphoma is one of the least investigated subjects in oncology. This article reports a case of cardiac involvement in Hodgkin's lymphoma which presented as heart failure. Case presentation We report the case of an 8-year-old Afghan girl with Hodgkin's lymphoma. The disease presented with systemic signs and symptoms, including abdominal distension, weakness, pallor, chills, fever, generalized edema, hepatosplenomegaly and generalized lymphadenopathy, as well as signs of heart failure. Test results showed a rare form of heart metastasis. Conclusion We report a case of Hodgkin's lymphoma with metastasis to the heart, detected premortem. Although the involvement of the heart in a malignancy is relatively common, premortem detection is unusual and only few studies have reported it in the literature. PMID:20205760

2010-01-01

170

[Hodgkin's lymphoma in nuclear medicine: diagnostic and therapeutic aspects].  

PubMed

Today, diagnostic and therapeutic strategies of Hodgkin lymphoma (HL) with positron emission tomography and radioimmunotherapy include state-of-the-art nuclear medicine which require the cooperation between oncology and nuclear medicine. The benefit of FDG-PET in HL patients with residual tumor masses consists of its high negative predictive value in the therapy control of the disease. The concept of waitful watching in patients with PET-negative residual masses after BEACOPP-chemotherapy will be evaluated in a large multicenter trial of the GHSG (German Hodgkin Study Group). Radioimmunotherapy has been performed in patients with CD20-positive Non-Hodgkin lymphoma for 10 years with promising results. HL is also an excellent target for immunotherapy due to the expression of antigens such as CD25 and CD30. Thus, a new radioimmunoconstruct consisting of the murine anti-CD30 antibody Ki-4 labeled with iodine-131 was developed for patients with relapsed or refractory HL. PMID:12601450

Staak, J O; Dietlein, M; Engert, A; Weihrauch, M R; Schomäcker, K; Fischer, Th; Eschner, W; Borchmann, P; Diehl, V; Schicha, H; Schnell, R

2003-02-01

171

Breast Cancer After Treatment of Hodgkin's Lymphoma: General Review  

SciTech Connect

The improved survival rates among patients with Hodgkin's lymphoma over the past few decades have come with increased incidence of second malignancies. One of the major concerns among female survivors is the significantly elevated risk of breast cancer that appears with extended follow-up. In this review, we include the published literature regarding the risk of breast cancer after irradiation for Hodgkin's lymphoma. We also present the possible long-term surveillance strategies and the optimal time to start screening these women. This could potentially help in early detection of secondary breast cancers and consequently improve outcomes. Furthermore, because of prior radiotherapy, the management of the breast cancer among this unique population has been controversial. We discuss the characteristics of breast cancer that occurs after Hodgkin's lymphoma and also treatment options that could be implemented.

Alm El-Din, Mohamed A. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Department of Radiation Oncology, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta (Egypt); El-Badawy, Samy A. [Department of Radiation Oncology, National Cancer Institute, Cairo University, Cairo (Egypt); Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)], E-mail: ataghian@partners.org

2008-12-01

172

Chinese Children's Songs.  

ERIC Educational Resources Information Center

Singing can be an enjoyable and effective way to motivate children to learn a second language. This booklet consists of contemporary and folk songs that are related to Chinese festivals, transportation, the family, seasons, Christmas and other topics. Each page gives the music to a song with the words in Chinese and in English. The songs are…

Kwok, Irene, Comp.

173

Chinese by Choice  

ERIC Educational Resources Information Center

A 2004 College Board survey revealed that school districts around America wanted to offer Chinese, but finding qualified teachers was a problem, says Selena Cantor, director of Chinese Language and Culture Initiatives for the College Board. So last year, a new College Board program brought guest teachers from China to school districts in 31…

Beem, Kate

2008-01-01

174

ZU CHONGZHI CHINESE CALENDAR  

E-print Network

ZU CHONGZHI AND THE CHINESE CALENDAR REFORM OF 462 AD A GEM1506K PROJECT BY: LIM NYEK FONG ELAYNE: AN OVERVIEW OF CHINESE CALENDARS AND ASTRONOMY UP TO ZU CHONGZHI'S TIME SECTION 4: ASPECTS OF THE DAMING CALENDAR REFORM SECTION 5: THE ZU CHONGZHI ­ DAI FAXING DEBATE SECTION 6: HOW EFFECTIVE WAS THE DAMING

Aslaksen, Helmer

175

The Chinese Calendars  

Microsoft Academic Search

In this article we try to answer the question how and why did Chinese ancient astronomy came into being and how did one lonesome and original calendar system on the very end of the world develop. At the beginning, Chinese people distinguished time of the year by the annual cycles of plants and animals, but soon began to determine seasons

N. Kostic; S. Segan

2009-01-01

176

The Chinese Calendars  

NASA Astrophysics Data System (ADS)

In this article we try to answer the question how and why did Chinese ancient astronomy came into being and how did one lonesome and original calendar system on the very end of the world develop. At the beginning, Chinese people distinguished time of the year by the annual cycles of plants and animals, but soon began to determine seasons by observing celestial bodies. Early successful measuring of tropical year and synodic month made possible for Chinese people to issue first calendars very early. Spring and Autumn (Chunqiu) period (770 - 476 BC) brought forward first official calendars. Further improvement of calendars is due to the development of new astronomical instruments. Chinese calendars also originate from the metaphysical concepts of Qi, Yin-Yang and 5 elements. 5 elements were connected with Chinese 5 seasons of the year and this was the first form of solar calendar. Later, it developed into solar calendar with 10 months. In the next phase, Chinese calendar turned into lunisolar calendar which also has its evolution. Chinese people invented Calendar "with division by four" (the name of this calendar). They also added 24 solar terms to make calendar harmonize with natural cycles. Li Chunfeng rearranged intercalations and used month without main solar term and divided months into short and long months. Sexagesimal system of time measuring refers to the system of Chinese 10 Heavenly Stems and 12 Earthly Branches. Its purpose is to measure time and define years, months, days and hours.

Kostic, N.; Segan, S.

2009-09-01

177

Ancient Chinese Kitchens  

E-print Network

Broadcast Transcript: Few people don't love Chinese food: The delicate flavors; the bite size pieces; the flavorful sauces; the healthful spices. Well, here's at least one reason why Chinese food is so good: they've been cooking it for about 3...

Hacker, Randi

2012-06-04

178

QUESTIONS IN CHINESE.  

ERIC Educational Resources Information Center

THIS ARTICLE, BASED ON A CONTRASTIVE ANALYSIS OF AMERICAN ENGLISH AND CHINESE, IS DESIGNED TO BE USED IN THE PREPARATION OF INSTRUCTIONAL MATERIALS FOR THE PRESENTATION OF QUESTIONS IN THE TEACHING OF CHINESE. QUESTIONS CAN BE CLASSIFIED INTO THREE CATEGORIES, ACCORDING TO THEIR FUNCTIONS--(1) PURE QUESTIONS, (2) RHETORICAL QUESTIONS, AND (3)…

TSAO, WEN YEN

179

Ancient Chinese mathematics  

NSDL National Science Digital Library

This website contains a timeline and examples of early Chinese mathematics. Included are the Chinese version of the Pythagorean Theorem, a method of solving a system of linear equations, Pascals triangle, permutations and combinations, rule of false position, rule of three, magic squares, and puzzles. Other terms: fractions, algebra, negative numbers, scholars. (Includes 11 references)

Tommasina Tripodi,Joint Creator

2007-12-12

180

Growing Up the Chinese Way: Chinese Child and Adolescent Development.  

ERIC Educational Resources Information Center

This volume is a collection of current research by noted scholars on Chinese child development. The volume re-examines long-held beliefs and preconceptions about Chinese culture, draws forth incompatible pictures and contradictory facts about Chinese children, and draws attention to new problems of the modern Chinese family. The chapters of the…

Lau, Sing, Ed.

181

Chinese paternalistic leadership and non-Chinese subordinates' psychological health  

Microsoft Academic Search

Past research on Chinese leadership, a style which is different from that practiced in the West, has demonstrated that paternalistic leadership within Chinese society is significantly related to employees' psychological health. This research contributes to the literature by providing results from the interaction between Chinese and non-Chinese society and examining the moderating role played by the cultural value of uncertainty

Hao-Yi Chen; Henry Shang-Ren Kao

2009-01-01

182

Non-Hodgkin's Malignant Lymphoma with Aggressive Development  

PubMed Central

ABSTRACT Non-Hodgkin's malignant lymphoma is a hematologic malignant disease which usually responds to the polychemotherapy. We present a clinical case report of a 50 years old patient who develops an aggressive type of lymphoma. Patient develops a nodal Non-Hodgkin's malignant lymphoma who present at hospital admission as a huge tumor at the right side of the neck. Any type of treatment was a failure, the patient having a particularly aggressive form of lymphoma, resistant to all three chemotherapy regimens tested. Death occurs quickly, about one year after diagnosis and initiation of therapy. PMID:25553129

DANCIU, Cezara Elisabeta; HEROIU (CATALOIU), Adriana-Daniela; POPESCU, Cristian Radu

2014-01-01

183

Current strategies of antibody-based treatment in Hodgkin's disease.  

PubMed

Many new approaches involving antibody-based agents have given promising results in experimental Hodgkin's disease (HD) models. Clinical trials with monoclonal antibodies, immunotoxins, bispecific constructs and radioimmunoconjugates have demonstrated some clinical efficacy in patients with advanced refractory HD. Although it seems unlikely that resistant patients with larger tumor masses will be cured by either of these approaches, it might be feasible to treat bulky disease by conventional therapy and then administer biological agents to kill residual Hodgkin and Reed-Sternberg cells. Future phase III trials will have to prove a possible superior effect of this combined immunochemotherapy. Currently, the evaluation of the most promising approaches continues. PMID:12078905

Schnell, R; Borchmann, P; Schulz, H; Engert, A

2002-01-01

184

Hodgkin's disease of the thymus: a rare mediastinal cystic mass.  

PubMed

We report a 14-year-old patient referred to us because of chest pain. A huge upper anterior mediastinal mass with several cystic spaces within it was found and resected. Pathologic diagnosis was nodular sclerosis Hodgkin's disease of the thymus. Radiotherapy was started after accurate surgical staging, and the patient remains free of disease 24 months later. Cavitation of the gland in Hodgkin's disease of the thymus should be taken into consideration when dealing with upper anterior mediastinal cystic masses in children. Surgery is probably unavoidable in this group of patients and, interestingly, can account in part for the relatively good prognosis in this localized form of the disease. PMID:3323456

Nogués, A; Tovar, J A; Suñol, M; Palacio, M; Albisu, J

1987-11-01

185

Non-Hodgkins Lymphoma presenting as Garcin's Syndrome.  

PubMed

An 80 year old man presented with a twelve month history of progressive multiple unilateral cranial nerve palsies. A gadolinium enhanced MRI scan of his head and neck was performed. This showed an extra-axial enhancing lesion, which enveloped the hemi-mandible at the level of the left inferior alveolar nerve, and a dumbbell shaped lesion within the cerebellopontine angle. An incisional biopsy was performed to gain a tissue diagnosis, which demonstrated a Non-Hodgkin's Lymphoma. The combination of signs, symptoms and radiological findings enabled a diagnosis of Garcin's Syndrome secondary to Non-Hodgkin's Lymphoma. PMID:24950551

Hammond, D; Rehman, K; Grew, N

2011-01-01

186

Four Proofs of the Converse of the Chinese Remainder Theorem  

ERIC Educational Resources Information Center

Four proofs, designed for classroom use in varying levels of courses on abstract algebra, are given for the converse of the classical Chinese Remainder Theorem over the integers. In other words, it is proved that if m and n are integers greater than 1 such that the abelian groups [double-struck z][subscript m] [direct sum] [double-struck…

Dobbs, D. E.

2008-01-01

187

Modern Chinese: History and Sociolinguistics.  

ERIC Educational Resources Information Center

This book presents a comprehensive and up-to-date account of the development of modern Chinese from the late 19th century up to the 1990s, concentrating on three major aspects: modern spoken Chinese, modern written Chinese, and the modern Chinese writing system. It describes and analyzes in detail, from historical and sociolinguistic perspectives,…

Chen, Ping

188

Jesuit Interpretations of the Yijing (Classic of Changes) in  

E-print Network

There Are Regions, Culture Areas, and National States: A Review Article," Journal of Southeast Asian Studies 33 for a series of scholarly studies on the Yijing (I Ching or Classic of Changes),1 argues 1 The first volume Perspectives," Journal of Chinese Philoso- 1 #12;Jesuit Interpretations of the Yijing that the use

Fiebig, Peter

189

Season of birth and risk of Hodgkin and non-Hodgkin lymphoma.  

PubMed

Infectious etiologies have been hypothesized for Hodgkin and non-Hodgkin lymphoma (HL and NHL) in early life, but findings to date for specific lymphomas and periods of susceptibility are conflicting. We conducted the first national cohort study to examine whether season of birth, a proxy for infectious exposures in the first few months of life, is associated with HL or NHL in childhood through young adulthood. A total of 3,571,574 persons born in Sweden in 1973-2008 were followed up through 2009 to examine the association between season of birth and incidence of HL (943 cases) or NHL (936 cases). We found a sinusoidal pattern in NHL risk by season of birth (p?=?0.04), with peak risk occurring among birthdates in April. Relative to persons born in fall (September-November), odds ratios for NHL by season of birth were 1.25 [95% confidence interval (CI), 1.04-1.50; p?=?0.02] for spring (March-May), 1.22 (95% CI, 1.01-1.48; p?=?0.04) for summer (June-August) and 1.11 (95% CI, 0.91-1.35; p?=?0.29) for winter (December-February). These findings did not vary by sex, age at diagnosis or major subtypes. In contrast, there was no seasonal association between birthdate and risk of HL (p?=?0.78). In this large cohort study, birth in spring or summer was associated with increased risk of NHL (but not HL) in childhood through young adulthood, possibly related to immunologic effects of delayed infectious exposures compared with fall or winter birth. These findings suggest that immunologic responses in early infancy may play an important role in the development of NHL. PMID:24752499

Crump, Casey; Sundquist, Jan; Sieh, Weiva; Winkleby, Marilyn A; Sundquist, Kristina

2014-12-01

190

Novel Drug Effectively Shrinks Tumors in Hodgkin Lymphoma  

Cancer.gov

An investigational drug composed of a monoclonal antibody linked to a potent chemotherapy agent led to complete or substantial tumor shrinkage in nearly 40 percent of patients with Hodgkin lymphoma in a phase I clinical trial, researchers reported November 4, 2010, in the New England Journal of Medicine.

191

Acute toxoplasmosis-etiological factor for development of Hodgkin's lymphoma?  

PubMed

The case of an HIV-positive man treated for acute toxoplasmosis with no traces of malignancy is reported. A second lymph node extirpation was performed after 5 months, which identified the presence of Hodgkin and Reed-Sternberg (HRS) cells. This case suggests that toxoplasmosis may cause changes in the regulation of surrounding cells and induce neoplastic proliferation. PMID:23848412

Snopkova, Svatava; Pohanka, Miroslav; Polak, Pavel; Havlickova, Katerina; Jarkovsky, Ji?i; Moulis, Mojmir; Stroblova, Hana; Husa, Petr

2013-12-01

192

Bendamustine in the treatment of non-Hodgkin’s lymphomas  

PubMed Central

Purpose: To review available data using bendamustine alone and in combination with other chemotherapeutic agents in treatment of patients with non-Hodgkin’s lymphomas. Methods: Internet database searches and literature review. Results: Bendamustine was approved in March 2008 by the United States Food and Drug Administration for the treatment of patients with chronic lymphocytic leukemia. Many trials have been performed over the last decade using bendamustine not only as monotherapy, but also in combination with other agents including rituximab, vincristine, mitoxantrone, fludarabine, and other agents as therapy for patients with relapsed non-Hodgkin’s lymphomas, and recently was approved for use in therapy of patients with relapsed indolent lymphomas considered refractory to rituximab therapy. As monotherapy, bendamustine induces good responses with only minor side effects. In combination with other agents, efficacy improves, especially when given in combination with rituximab. The drug has also been studied in combination with rituximab as initial therapy for indolent lymphomas, and has excellent activity with less toxicity than R-CHOP (rituximab – cyclophosphamide, hydroxydaunorubicin [Adriamycin], Oncovin [vincristine], and prednisone/prednisolone). Conclusion: Overall, bendamustine has demonstrated promising results as therapy for non-Hodgkin’s lymphomas and should be included in the armamentarium of agents used to treat relapsed indolent non-Hodgkin’s lymphomas and may prove valuable as initial therapy for these diseases. Further studies are being conducted to demonstrate the efficacy of this drug in combination with other agents. PMID:20616914

Hagemeister, Fredrick; Manoukian, George

2009-01-01

193

Primary non-Hodgkin's lymphoma of the sinonasal tract  

Microsoft Academic Search

ObjectivesWe sought to review the records of patients seen at the Chaim Sheba Medical Center (Tel Hashomer, Israel) during a 10-year period with respect to the presenting features, management, and outcome of extranodal non-Hodgkin's lymphoma (NHL) of the sinonasal region.

Izhar Shohat; Miriam Berkowicz; Shai Dori; Zeev Horowitz; Michael Wolf; Shlomo Taicher; Yoav P Talmi

2004-01-01

194

Radiographic appearance of the chest following therapy for Hodgkin disease  

Microsoft Academic Search

This study was carried out to define the post-treatment appearance of the chest radiographs in 44 consecutive patients with Hodgkin disease who received mantle irradiation with or without chemotherapy and to determine how the incidence and severity of post-treatment abnormalities relate to the radiation parameters and chemotherapeutic regimens. Radiographs of the chest in 44 patients, computed tomograms of the chest

Evelyne Loyer; Lillian Fuller; Herman I Libshitz; J. Lynn Palmer

2000-01-01

195

Trial Suggests New Treatment Option for Hodgkin Lymphoma  

Cancer.gov

Intermediate results from a phase II clinical trial presented at the 2010 American Society of Hematology annual meeting indicate that an investigational agent called brentuximab vedotin may be an effective alternative for some patients with Hodgkin lymphoma who have few viable treatment options.

196

Non-Hodgkin lymphoma originating from the frontal sinus.  

PubMed

Primary lymphoma of the paranasal sinuses is a rare entity. Most cases are reported to occur in the maxillary and ethmoid sinuses as well as the nasal cavity. Primary involvement of the frontal sinus is very rare. We report a 68-year-old man with a diagnosis of B-cell lymphoma (non-Hodgkin lymphoma) originating from his frontal sinus. PMID:25006942

Haksever, Mehmet; Gündo?du, Ercan; Akduman, Davut; Haksever, Hülya; Karaca, Kemal; Ekici, Mehmet Ali; Solmaz, Fevzi

2014-07-01

197

Role of the gallium scan in Hodgkin's disease  

Microsoft Academic Search

The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patients studied. There were no significant differences in overall results between newer

Fredrick B. Hagemeister; Susan M. Fesus; Lamk M. Lamki; Thomas P. Haynie

1990-01-01

198

The ancient Chinese notes on hydrogeology  

NASA Astrophysics Data System (ADS)

The ancient Chinese notes on hydrogeology are summarized and interpreted, along with records of some related matters, like groundwater exploration and utilization, karst springs, water circulation, water conservation and saline-land transformation, mine drainage, and environmental hydrogeology. The report focuses only on the earliest recorded notes, mostly up until the Han Dynasty (206 BC - AD 25). Besides the references cited, the discussion in this report is based mainly on archaeological material, the preserved written classic literature, and some assumptions and/or conclusions that have been handed down in legends to later ages. Although most material relates to ancient China, the lessons learned may have practical significance worldwide. Compared to other contemporary parts of the world, ancient China, without doubt, took the lead in the field of groundwater hydrology. The great achievements and experience of the Chinese ancestors should provide motivation and inspiration for hydrogeologists to carry out their scientific research and exploration passionately and actively.

Zhou, Yu; Zwahlen, François; Wang, Yanxin

2011-08-01

199

Spotlight on Confucius: Chinese Classics and Cultural Values. Updated.  

ERIC Educational Resources Information Center

This updated set of lesson plans focuses on Confucius and Confucian thought, especially Confucian ethics. The lesson plans are divided into the following chapters: (1) "How do the Analects embody the ethical framework of Confucian thought?"; (2) "How does Confucianism affect behavior, attitudes and beliefs?"; (3) "How did other belief systems…

Arkin, Linda, Ed.

200

Inconsistency in Classical Electrodynamics?  

Microsoft Academic Search

In a recent issue of this journal, M. Frisch claims to have proven that classical elec- trodynamics is an inconsistent physical theory. We argue that he has applied classical electrodynamics inconsistently. Frisch also claims that all other classical theories of electromagnetic phenomena, when consistent and in some sense an approximation of classical electrodynamics, are haunted by \\

F. A. Muller

2007-01-01

201

Association between simian virus 40 and non-Hodgkin lymphoma  

NASA Technical Reports Server (NTRS)

BACKGROUND: Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma. METHODS: We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses. FINDINGS: Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas. INTERPRETATION: SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

Vilchez, Regis A.; Madden, Charles R.; Kozinetz, Claudia A.; Halvorson, Steven J.; White, Zoe S.; Jorgensen, Jeffrey L.; Finch, Chris J.; Butel, Janet S.

2002-01-01

202

Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I AIDS-related Lymphoma; Stage II AIDS-related Lymphoma; Stage III AIDS-related Lymphoma; Stage IV AIDS-related Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

2014-12-15

203

Image database analysis of Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma (HL) is a special type of B cell lymphoma, arising from germinal center B-cells. Morphological and immunohistochemical features of HL as well as the spatial distribution of malignant cells differ from other lymphoma and cancer types. Sophisticated protocols for immunostaining and the acquisition of high-resolution images become routine in pathological labs. Large and daily growing databases of high-resolution digital images are currently emerging. A systematic tissue image analysis and computer-aided exploration may provide new insights into HL pathology. The automated analysis of high resolution images, however, is a hard task in terms of required computing time and memory. Special concepts and pipelines for analyzing high-resolution images can boost the exploration of image databases. In this paper, we report an analysis of digital color images recorded in high-resolution of HL tissue slides. Applying a protocol of CD30 immunostaining to identify malignant cells, we implement a pipeline to handle and explore image data of stained HL tissue images. To the best of our knowledge, this is the first systematic application of image analysis to HL tissue slides. To illustrate the concept and methods we analyze images of two different HL types, nodular sclerosis and mixed cellularity as the most common forms and reactive lymphoid tissue for comparison. We implemented a pipeline which is adapted to the special requirements of whole slide images of HL tissue and identifies relevant regions that contain malignant cells. Using a preprocessing approach, we separate the relevant tissue region from the background. We assign pixels in the images to one of the six predefined classes: Hematoxylin(+), CD30(+), Nonspecific red, Unstained, Background, and Low intensity, applying a supervised recognition method. Local areas with pixels assigned to the class CD30(+) identify regions of interest. As expected, an increased amount of CD30(+) pixels is a characteristic feature of nodular sclerosis, and the non-lymphoma cases show a characteristically low amount of CD30(+) stain. Images of mixed cellularity samples include cases of high CD30(+) coloring as well as cases of low CD30(+) coloring. PMID:23764526

Schäfer, Tim; Schäfer, Hendrik; Schmitz, Alexander; Ackermann, Jörg; Dichter, Norbert; Döring, Claudia; Hartmann, Sylvia; Hansmann, Martin-Leo; Koch, Ina

2013-10-01

204

Subthreshold Oscillatory Responses of the Hodgkin-Huxley Cable Model for the Squid Giant Axon  

PubMed Central

The classical cable equation, in which membrane conductance is considered constant, is modified by including the linearized effect of membrane potential on sodium and potassium ionic currents, as formulated in the Hodgkin-Huxley equations for the squid giant axon. The resulting partial differential equation is solved by numerical inversion of the Laplace transform of the voltage response to current and voltage inputs. The voltage response is computed for voltage step, current step, and current pulse inputs, and the effect of temperature on the response to a current step input is also calculated. The validity of the linearized approximation is examined by comparing the linearized response to a current step input with the solution of the nonlinear partial differential cable equation for various subthreshold current step inputs. All the computed responses for the squid giant axon show oscillatory behavior and depart significantly from what is predicted on the basis of the classical cable equation. The linearization procedure, coupled with numerical inversion of the Laplace transform, proves to be a convenient approach which predicts at least qualitatively the subthreshold behavior of the nonlinear system. PMID:5824410

Sabah, N. H.; Leibovic, K. N.

1969-01-01

205

Clustering of cancer among families of cases with Hodgkin Lymphoma (HL), Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), Soft Tissue Sarcoma (STS) and control subjects  

Microsoft Academic Search

BACKGROUND: A positive family history of chronic diseases including cancer can be used as an index of genetic and shared environmental influences. The tumours studied have several putative risk factors in common including occupational exposure to certain pesticides and a positive family history of cancer. METHODS: We conducted population-based studies of Hodgkin lymphoma (HL), Multiple Myeloma (MM), non-Hodgkin's Lymphoma (NHL),

Helen H McDuffie; Punam Pahwa; Chandima P Karunanayake; John J Spinelli; James A Dosman

2009-01-01

206

Stage IV and age over 45 years are the only prognostic factors of the International Prognostic Score for the outcome of advanced Hodgkin lymphoma in the Spanish Hodgkin Lymphoma Study Group series.  

PubMed

The International Prognostic Score (IPS) is the most widely used system to date for identifying risk groups for the outcome of patients with advanced Hodgkin lymphoma, although important limitations have been recognized. We analyzed the value of the IPS in a series of 311 patients with advanced classical Hodgkin lymphoma (cHL) (Ann Arbor stage III, IV or stage II with B symptoms and/or bulky masses) treated with first-line chemotherapy including adriamycin (adriamycin, bleomycin, vinblastine, dacarbazine [ABVD] or equivalent variants). In univariate and multivariate analyses, stage IV disease and age ? 45 years were the only factors with independent predictive significance for overall survival (OS) (p = 0.002 and p < 0.001, respectively). Stage IV was still significant for freedom from progression (FFP) (p = 0.001) and age ? 45 years was borderline significant (p = 0.058). IPS separates prognostic groups, as in the original publication, but this is mainly due to the high statistical significance of stage IV and age ? 45 years. Moreover, the combination of these two factors enables a simpler system to be constructed that separates groups with different FFP and OS. In conclusion, in our series, stage IV and age ? 45 years are the key prognostic factors for the outcome of advanced cHL. PMID:22185637

Guisado-Vasco, Pablo; Arranz-Saez, Reyes; Canales, Miguel; Cánovas, Araceli; Garcia-Laraña, José; García-Sanz, Ramón; Lopez, Andrés; López, José Luis; Llanos, Marta; Moraleda, José Maria; Rodriguez, José; Rayón, Consuelo; Sabin, Pilar; Salar, Antonio; Marín-Niebla, Ana; Morente, Manuel; Sánchez-Godoy, Pedro; Tomás, José Francisco; Muriel, Alfonso; Abraira, Victor; Piris, Miguel A; Garcia, Juán F; Montalban, Carlos

2012-05-01

207

Chinese health beliefs of older Chinese in Canada.  

PubMed

Objectives. This study examines the cultural health beliefs held by older Chinese in Canada. Methods. Chinese surnames are randomly selected from the local Chinese telephone directories. Telephone screening is then conducted to identify eligible Chinese people 55 years of age or older to take part in a face-to-face interview to complete a structured survey questionnaire. Results. The results of exploratory factor analysis indicate that the health beliefs of the older Chinese are loaded onto three factors related to beliefs about traditional health practices, beliefs about traditional Chinese medicine, and beliefs about preventive diet. Education, religion, country of origin, length of residency in Canada, and city of residency are the major correlates of the various Chinese health beliefs scales. Discussion. The findings support the previous prescriptive knowledge about Chinese health beliefs and illustrate the intragroup sociocultural diversity that health practitioners should acknowledge in their practice. PMID:19144968

Lai, Daniel W L; Surood, Shireen

2009-02-01

208

Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin's disease  

SciTech Connect

Sideroblastic anemia after treatment for Hodgkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. This was followed in both by the development of myelomonoblastic leukemia. No evidence of recurrent Hodgkin's disease was present in either patient. Our observation suggests that development of sideroblastic anemia in patients previously treated for Hodgkin's disease is probably secondary to the treatment and is a preleukemic event.

Kitahara, M.; Cosgriff, T.M.; Eyre, H.J.

1980-05-01

209

Flow-sorting and exome sequencing reveals the oncogenome of primary Hodgkin and Reed-Sternberg cells.  

PubMed

Classical Hodgkin lymphoma (cHL) is characterized by sparsely distributed Hodgkin and Reed-Sternberg (HRS) cells amidst reactive host background, complicating the acquisition of neoplastic DNA without extensive background contamination. We overcame this limitation using flow-sorted HRS and intra-tumor T cells and optimized low-input exome sequencing of ten patient samples to reveal alterations in genes involved in antigen presentation, chromosome integrity, transcriptional regulation, and ubiquitination. Beta-2-microglobulin (B2M) is the most commonly altered gene in HRS cells with 7/10 of the cases having inactivating mutations that lead to loss of MHC class I expression. Enforced wild type B2M expression in a cHL cell line restored MHC class I expression. In an extended cohort of 145 patients, the absence of B2M protein in the HRS cells was associated with lower stage of disease, younger age at diagnosis, and better overall and progression-free survival. B2M deficient cases encompassed most cases of the nodular sclerosis subtype and only a minority of mixed cellularity cases, suggesting that B2M deficiency determines the tumor microenvironment and may define a major subset of cHL with more uniform clinical and morphologic features. In addition, we report previously unknown genetic alterations that may render selected cases sensitive to specific targeted therapies. PMID:25488972

Reichel, Jonathan; Chadburn, Amy; Rubinstein, Paul G; Giulino-Roth, Lisa; Tam, Wayne; Liu, Yifang; Gaiolla, Rafael; Eng, Kenneth; Brody, Joshua; Inghirami, Giorgio; Carlo-Stella, Carmelo; Santoro, Armando; Rahal, Daoud; Totonchy, Jennifer; Elemento, Olivier; Cesarman, Ethel; Roshal, Mikhail

2014-12-01

210

Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage

2014-08-08

211

Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage

2015-01-29

212

Ixazomib Citrate in Treating Patients With Untreated B-cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

B-Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Small Lymphocytic Lymphoma; Waldenstrom Macroglobulinemia

2015-01-12

213

Teaching Chinese Negotiating Style through Examination of Key Chinese Categories.  

ERIC Educational Resources Information Center

This study examined different shades of meaning that a single word may have in Chinese in an effort to better understand the relationship between language and culture. An understanding of the exact meaning of Chinese words and expressions can greatly assist non-Chinese in understanding both the language and the society as a whole. A total of 102…

Myers, Dan

214

The Early Chinese Canadians  

NSDL National Science Digital Library

This bilingual website offered by the Library and Archives of Canada (LAC) explores Canada's early Chinese immigrants, covering the period 1858 to 1947. To learn why the Chinese immigrated to Canada, visitors should click on "The History" on the far left side of the page. Once there, visitors can choose from several specific sections to read about, including "Working in B.C.: Gold, Railway, Mining and Salmon", "Racism and Law in Society", and "Communities for Canada and China". Additionally, each contains suggestions for further reading on the subject for both adults and children. Visitors who desire to browse photos and documents can click on "Historical Photographs and Documents" on the far left side of the page. There are three sections, "Research Guide", "Gallery of Documents", and "Gallery of Photographs". The Research Guide provides a thorough explanation on how to research the "photographs, artwork, published books, personal archives, and, in particular, government records" of Chinese Canadians, which are dispersed throughout the LAC collection. The documents and photographs galleries allow visitors to view, and even order, a print or digital copy of the historic materials. Finally, the "Head Tax Records" link located on the far left side of the page, allows visitors to search for Chinese immigrants to Canada that were recorded in the General Registers of Chinese Immigration. Visitors can search these registers online by the person's name, arrival year, or certificate number. [KMG

215

Ancient Chinese Astronomical Technologies  

NASA Astrophysics Data System (ADS)

I am interested in the astronomical advances of the Ancient Chinese in measuring the solar day. Their development of gnomon & ruler, sundial, and water clock apparatuses enabled Chinese astronomers to measure the annual solar orbit and solar day more precisely than their contemporaries. I have built one of each of these devices to use in collecting data from Olympia, Washington. I will measure the solar day in the Pacific Northwest following the methodology of the ancient Chinese. I will compare with my data, the available historical Chinese astronomical records and current records from the United States Naval Observatory Master Clock. I seek to understand how ancient Chinese investigations into solar patterns enabled them to make accurate predictions about the movement of the celestial sphere and planets, and to develop analytic tests of their theories. Mayall, R. Newton; Sundials: their construction and use. Dover Publications 2000 North, John; The Norton History of Astronomy and Cosmology W.W. Norton& Co. 1995 Zhentao Xu, David W. Pankenier, Yaotiao Jiang; East Asian archaeoastronomy : historical records of astronomical observations of China, Japan and Korea Published on behalf of the Earth Space Institute by Gordon and Breach Science Publishers, c2000

Walsh, Jennifer Robin

2004-05-01

216

Hypereosinophilic syndrome with Hodgkin's-like lymphoma in a ferret.  

PubMed

Hodgkin's-like lymphoma involving the lung, mediastinum, liver, kidneys and mesenteric lymph nodes was diagnosed in a ferret. The diagnosis was based on the presence of an admixture of CD3+ small lymphocytes with smaller numbers of macrophages, eosinophils, and large, pleomorphic, frequently multinucleated, Reed-Sternberg-like cells which were immunoreactive to BLA.36 monoclonal antibody. In addition, the liver, pancreas, small intestine and lungs were infiltrated with moderate to large numbers of eosinophils, forming eosinophilic granulomas with occasional deposition of Splendore-Hoeppli material, supporting a diagnosis of hypereosinophilic syndrome. The concurrent diagnosis of hypereosinophilic syndrome and Hodgkin's-like lymphoma in this ferret provides further support to the concept that, in animals, multisystemic eosinophilic infiltrates may be caused by the abnormal proliferation of T lymphocytes, as has been demonstrated in man. PMID:10087494

Blomme, E A; Foy, S H; Chappell, K H; La Perle, K M

1999-02-01

217

Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin's lymphoma.  

PubMed

Recurrent cerebral venous thrombosis (CVT), as a manifestation of paraneoplastic angiitis and revealing of nodular lymphocyte predominant Hodgkin's disease (NLPHD), is an extremely rare condition. We herein report a 55-year-old man who developed recurrent CVT despite efficacious anticoagulant therapy and subsequent stenting of the superior longitudinal sinus. Progressive neurological deterioration ensued and a body scan revealed axillary lymph nodes. Pathological analysis led to a diagnosis of NLPHD. Conventional angiography showed CVT and multiple arterial narrowings. A paraneoplastic primary cerebral angiitis with prominent venous structure involvement was suspected. Immunotherapy using rituximab and steroids provided a dramatic recovery. This case of CVT due to paraneoplastic cerebral angiitis is a rare condition and represents a new, very rare manifestation of nodular lymphocyte predominant Hodgkin's disease. PMID:18461283

Roggerone, Stephanie; Traverse-Glehen, Alexandra; Derex, Laurent; Honnorat, Jerome; Berger, Francoise; Salles, Gilles; Rousset, Hugues; Trouillas, Paul; Nighoghossian, Norbert

2008-09-01

218

Unusual thoracic radiographic findings in children treated for Hodgkin's disease  

SciTech Connect

Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

1986-06-01

219

Diagnosis and treatment of Hodgkin's lymphoma: at times a challenge.  

PubMed

Hodgkin's lymphoma has been traditionally defined as a hematopoietic neoplasm composed of diagnostic Reed-Sternberg cells. More than 70% of the cases involve cervical or supraclavicular lymph nodes. Isolated sub-diaphragmatic lymphadenopathy or organ involvement is rare. We present the case of Hodgkin's lymphoma in a 51 years old female, who presented with obstructive jaundice and lymphadenopathy, empirically treated previously as a case of tuberculosis. Chemotherapy with modified ABVD protocol was given with dose modification according to LFT's. Her liver functions returned to normal levels after the first cycle. The main purpose of reporting the case is to stress definitive diagnosis of the disease before initiating treatment and the modified chemotherapy regimen used in this infrequent presentation of the disease. PMID:24112267

Abbasi, Nadeem Zia; Jalal-ud-Din, Mir; Zahur, Zainab; Khan, Amjad Aziz; Sheikh, Abdul Samad; Ali, Furqan; Memon, Khalid Hussain

2013-10-01

220

The Internet Classics Archive  

NSDL National Science Digital Library

The Internet Classics Archive has recently been extensively updated and more than doubled in size. This premier classical literature resource now offers 375 works by 30 classical authors, in English translation. The complete body of work is attractively and logically formatted for easy and swift browsing. It is supported by a newly improved search engine. The Tech Classics Archive is a non-commercial, student-created World-Wide Web site that will be one year old in October.

1998-01-01

221

Tracking and control of neuronal Hodgkin-Huxley dynamics  

PubMed Central

Nonlinear ensemble state estimation offers a paradigm-shifting improvement in our ability to observe, predict, and control the state of spiking neuronal systems. We use an ensemble Kalman filter to predict hidden states and future trajectories in the Hodgkin-Huxley equations, reconstruct ion dynamics, control neuronal activity including a strategy for dynamic conductance clamping, and show the feasibility of controlling pathological cellular activity such as seizures. PMID:19518166

Ullah, Ghanim; Schiff, Steven J.

2009-01-01

222

Non-Hodgkin's lymphoma causing extrinsic pulmonary artery compression  

Microsoft Academic Search

Acquired pulmonary stenosis in adults is rare and is usually caused by extrinsic compression from a mediastinal tumour. We present the case of a patient with high grade non-Hodgkin's lymphoma who presented with progressive exertional dyspnoea. Compression of the right pulmonary artery was diag- nosed by transthoracic echocardiography. A previously healthy 23-year-old panel beater present with a 3-month history of

Timothy Robinson; Jane Lynch; Ever Grech

223

Acute nonlymphocytic leukemia: onset after treatment for Hodgkin's disease  

Microsoft Academic Search

This study was undertaken to examine the influence of various factors on the occurrence of acute nonlymphocytic leukemia\\u000a (ANLL) in a group of long-term survivors of Hodgkin's disease (HD). From 1972 to 1992, 1045 patients with HD were assessed\\u000a and treated at the Department of Radiation Oncology, the Institute of Radiology, and the Department of Human Biopathology,\\u000a Hematology Section, University

R. Maurizi Enrici; A. P. Anselmo; M. F. Osti; M. Santoro; S. Sbarbati; V. Tombolini; F. Mandelli; E. D'Arcangelo; C. Biagini

1997-01-01

224

The Classical Vacuum.  

ERIC Educational Resources Information Center

The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Boyer, Timothy H.

1985-01-01

225

Directory of Chinese American Librarians.  

ERIC Educational Resources Information Center

This directory was compiled by the Chinese American Librarians Association based on replies to questionnaires sent to more than 500 Chinese American librarians in the United States and research based on secondary sources. Information provided on each person includes: name, name in Chinese, position/title, institution, institution's address, field…

Chinese American Librarians Association, River Forest, IL.

226

When Is Chinese New Year?  

Microsoft Academic Search

Chinese New Year is the main holiday for more than one quarter of the world's population; very few people, however, know how to compute the date. People who are knowledgeable about science often feel that the Chinese calendar is back-wards, while people who care about Chinese culture usually lack the scientific knowledge to understand how it works. For many years,

Helmer Aslaksen

227

Thymic involvement in Hodgkin disease: CT and sonographic findings.  

PubMed

To evaluate the morphologic characteristics and frequency of thymic enlargement in Hodgkin disease, the initial and follow-up computed tomographic (CT) scans of 43 patients with newly diagnosed Hodgkin lymphoma were retrospectively analyzed. Sonograms of the thymic region in 21 patients were also available and were compared with the CT scans. Initial CT scans showed thymic enlargement in 17 of the 43 patients, no evidence of thymic enlargement in 15 patients, and equivocal findings in 11 patients. Analysis of follow-up CT scans indicated that seven of the 11 patients with initially equivocal findings had had thymic enlargement. In all seven patients, the anterior mediastinal tumor shrank with therapy and adopted a typical tongue-shaped thymic configuration. In nine of the 24 patients with thymic enlargement, the thymus remained enlarged after therapy and full clinical remission. The comparison of sonograms and CT scans showed that sonography could not help differentiate the normal-size thymus from surrounding fatty tissue. All thymic glands that were considered diseased because of enlargement at CT were sonographically visible due to an abnormal, hypoechoic structure. The results of the study show that thymic enlargement presumed to be due to involvement by Hodgkin disease seems to occur more frequently than previously reported. PMID:1924775

Wernecke, K; Vassallo, P; Rutsch, F; Peters, P E; Potter, R

1991-11-01

228

Primary non-Hodgkin's lymphoma of the mediastinum  

SciTech Connect

Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6%) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extrathoracic disease at presentation. Eleven of the 12 patients presented with extensive contiguous extranodal disease (Stage II/sub E/) with involvement of either the pericardium, sternum, chest wall, pulmonary parenchyma or, in four cases, with superior venacaval obstruction. Diffuse large cell lymphoma (eight cases) and diffuse poorly differentiated lymphocytic lymphoma (four cases) were the prevalent histologic subtypes; no instances of lymphoblastic lymphoma without extra-thoracic spread were encountered. None of four lymphomas studied could be characterized as either B- or T-cell tumors utilizing conventional surface marker techniques. Ten of the 12 patients achieved complete remissions, either after treatment with combination chemotherapy alone (three patients) or after both chemotherapy and mediastinal irradiation (seven patients). Two of these ten have subsequently relapsed, but median survival has not been reached after a mean period of observation of 28 months. Primary nonlymphoblastic non-Hodgkin's lymphoma of the mediastinum is more common than previously realized, displays aggressive contiguous spread within the chest and responds well to combination chemotherapy with or without adjuvant mediastinal irradiation.

Levitt, L.J.; Aisenberg, A.C.; Harris, N.L.; Linggood, R.M.; Poppema, S.

1982-12-01

229

Bibliographies for Chinese Studies  

NSDL National Science Digital Library

Professor Dr. Barend ter Haar, an instructor in the social and economic history of China at the Sinologisches Seminar (Sinological Institute) at Heidelberg University, offers this collection of regularly updated (with one exception) bibliographies on various aspects of Chinese culture and history. Topics include violence in Chinese culture, literacy, writing and education, the study of Yao religion, Shamanism in China, and religious culture in China. Each bibliography varies in length, but most are prefaced by some helpful remarks on the field and/or the secondary literature. Suggestions are welcome.

230

A single institution experience on 314 newly diagnosed advanced Hodgkin lymphoma patients: the role of ABVD in daily practice.  

PubMed

Based on the results of clinical trials, there is no global consensus on the optimal first-line therapy for patients with advanced Hodgkin lymphoma (HL) with both ABVD and BEACOPP currently being used. However, the results of clinical trials are usually better than those in daily practice. We thus describe here our experience on 314 advanced classical HL patients treated with ABVD at the Clinical Center of Serbia and associated centers between 1997 and 2008. The median follow-up for all patients was 91 months; the estimated 5-yr event-free survival was 62% and the 5-yr overall survival (OS) 76%. Multivariate Cox regression analysis revealed that patients with IPS ? 3 and extranodal disease involving more than one site have a poorer outcome. The data presented here show on overall improvement in outcome as compared to more previous data and illustrate the problems of treating advanced stage HL outside the setting of a clinical trial. PMID:24797378

Andjelic, Bosko; Antic, Darko; Jakovic, Ljubomir; Todorovic, Milena; Bogdanovic, Andrija; Djurasinovic, Vladislava; Bila, Jelena; Mihaljevic, Biljana

2014-11-01

231

Reduced intensity conditioning allogeneic stem cell transplantation for Hodgkin’s lymphoma: identification of prognostic factors predicting outcome  

PubMed Central

Background The role of reduced intensity conditioning allogeneic stem transplantation (RICalloSCT) in the management of patients with Hodgkin’s lymphoma remains controversial. Design and Methods To further define its role we have conducted a retrospective analysis of 285 patients with HL who underwent a RICalloSCT in order to identify prognostic factors that predict outcome. Eighty percent of patients had undergone a prior autologous stem cell transplantation and 25% had refractory disease at transplant. Results Non-relapse mortality was associated with chemorefractory disease, poor performance status, age >45 and transplantation before 2002. For patients with no risk factors the 3-year non-relapse mortality rate was 12.5% compared to 46.2% for patients with 2 or more risk factors. The use of an unrelated donor had no adverse effect on the non-relapse mortality. Acute graft versus host disease (aGVHD) grades II–IV developed in 30% and chronic GVHD in 42%. The development of cGVHD was associated with a lower relapse rate. The disease progression rate at one and five years was 41% and 58.7% respectively and was associated with chemorefractory disease and extent of prior therapy. Donor lymphocyte infusions were administered to 64 patients for active disease of whom 32% showed a clinical response. Eight out of 18 patients receiving donor lymphocyte infusions alone had clinical responses. Progression-free and overall survival were both associated with performance status and disease status at transplant. Patients with neither risk factor had a 3-year PFS and overall survival of 42% and 56% respectively compared to 8% and 25% for patients with one or more risk factors. Relapse within six months of a prior autologous transplant was associated with a higher relapse rate and a lower progression-free. Conclusions This analysis identifies important clinical parameters that may be useful in predicting the outcome of RICaIICalloSCT in Hodgkin’s lymphoma. PMID:19066328

Robinson, Stephen P.; Sureda, Anna; Canals, Carmen; Russell, Nigel; Caballero, Dolores; Bacigalupo, Andrea; Iriondo, Arturo; Cook, Gordon; Pettitt, Andrew; Socie, Gerard; Bonifazi, Francesca; Bosi, Alberto; Michallet, Mauricette; Liakopoulou, Effie; Maertens, Johan; Passweg, Jakob; Clarke, Fiona; Martino, Rodrigo; Schmitz, Norbert

2009-01-01

232

Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome

2014-09-16

233

Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2010-12-08

234

Principles of diet therapy in ancient Chinese medicine: 'Huang Di Nei Jing'.  

PubMed

Huang Di Nei Jing, the first systematic Chinese medical book, was compiled from the observations of imperial herbal doctors in the Qin and Han periods (221 BC - 220 AD). From this classic traditional source may be derived the concept of a balanced and complete diet and probably the world's first dietary guidelines. Basic to the tradition are han, re, wen and bu foods, respectively 'cold', 'hot', 'neutral', 'strengthening'. Basic to Chinese cuisine are jan and tsai- 'cereal' (the rice staple and main meal) and 'dishes' to accompany the rice. Chinese traditional medicine, as in Huang Di Nei Jing, considers the nourishment of body and mind. It also emphasises that herbal medicine and food have the same origin. Diet was essential to the prevention of disease which a glossary of Chinese terms is given at the end of the paper in the Chinese tradition, was superior to treatment. PMID:24352105

Ho, Z C

1993-06-01

235

Chinese VLBI Network Project  

NASA Astrophysics Data System (ADS)

The Chinese VLBI Network (CVN) project was proposed early in 1979, and since then VLBI research has been actively developed in Shanghai Observatory. However, only recently the whole project was accepted by the Astronomy Committee, Division of Mathematics and Physics, Academia Sinica.

Wan, T. S.; Qian, Z.

236

The Chinese Way.  

ERIC Educational Resources Information Center

The article describes the active network of workers' education in China. Topics discussed include the broad range of disciplines available; school calendars; the use of guest teachers, televised programs, and self-study; and the new Chinese workers' audiovisual center. (CH)

Rongshu, Chen

1987-01-01

237

Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Hepatosplenic T-Cell Lymphoma; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma

2015-01-23

238

Striated pattern on scrotal ultrasonography: A marker for Non-hodgkins lymphoma of testis.  

PubMed

We present a case of 52 year old man who presented with bilateral painless testicular swelling. On evaluation with high resolution ultrasonography of the scrotum, typical "striated pattern" which is highly suggestive of Non Hodgkins lymphoma of the testis was seen. The patient underwent bilateral inguinal orchidectomy and the histopathological examination confirmed the diagnosis of Non Hodgkins lymphoma. PMID:24497696

Bhat, Suresh; Sachin, Joseph; Ramaprasad; Job, Suma

2014-01-01

239

Striated pattern on scrotal ultrasonography: A marker for Non-hodgkins lymphoma of testis  

PubMed Central

We present a case of 52 year old man who presented with bilateral painless testicular swelling. On evaluation with high resolution ultrasonography of the scrotum, typical “striated pattern” which is highly suggestive of Non Hodgkins lymphoma of the testis was seen. The patient underwent bilateral inguinal orchidectomy and the histopathological examination confirmed the diagnosis of Non Hodgkins lymphoma. PMID:24497696

Bhat, Suresh; Sachin, Joseph; Ramaprasad; Job, Suma

2014-01-01

240

FDA Expands Approved Use of Imbruvica for Rare Form of Non-Hodgkin Lymphoma  

MedlinePLUS

... approved use of Imbruvica for rare form of non-Hodgkin lymphoma First drug approved to treat Waldenström’s macroglobulinemia For ... therapy designation for this use. A type of non-Hodgkin lymphoma, WM usually gets worse slowly over time and ...

241

Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Hepatosplenic T-Cell Lymphoma; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma

2014-12-19

242

SURVIVAL AFTER CHILDHOOD ACUTE LEUKEMIA AND NON-HODGKIN'S LYMPHOMA IN FRANCE, 1990-2000.  

E-print Network

1/19 SURVIVAL AFTER CHILDHOOD ACUTE LEUKEMIA AND NON-HODGKIN'S LYMPHOMA IN FRANCE, 1990 describes the survival after childhood acute leukemia (AL) and non- Hodgkin's lymphoma (NHL) of the French population aged less than 15 years. The French National Registry of Childhood Leukemia and Lymphoma recorded

Paris-Sud XI, Université de

243

Proton therapy to the subdiaphragmatic region in the management of patients with Hodgkin lymphoma.  

PubMed

Twelve consecutive patients with classical Hodgkin lymphoma (HL) involving diaphragmatic or subdiaphragmatic regions were treated on an institutional review board-approved outcomes tracking protocol. All patients underwent treatment with proton therapy following chemotherapy and had comparative three-dimensional conformal photon radiotherapy (3DCRT) and intensity-modulated radiotherapy (IMRT) plans to evaluate differences in dose to organs at risk (OARs). Among the cohort, stomach doses with 3DCRT, IMRT and proton therapy were 21 Gy (median), 14 Gy and 6 Gy, respectively. Median dose reductions with proton therapy compared with 3DCRT and IMRT were 13 Gy (p = 0.0022) and 8 Gy (p = 0.0022) for the stomach. Additionally, there was significant dose reduction using proton therapy for the liver, pancreas, bowel, left kidney and right kidney. Proton therapy reduces the dose to the stomach, liver, pancreas, small bowel and kidneys compared with 3DCRT or IMRT in patients with HL requiring abdominal radiotherapy. These dose reductions are expected to translate into lower risks of secondary cancers and other late toxicities in survivors of HL. PMID:25315071

Sachsman, Suzanne; Hoppe, Bradford S; Mendenhall, Nancy P; Holtzman, Adam; Li, Zuofeng; Slayton, William; Joyce, Mike; Sandler, Eric; Flampouri, Stella

2014-11-19

244

Sacral pain as the initial symptom in primary Hodgkin's lymphoma of bone.  

PubMed

Progressive painless enlargement of peripheral lymph nodes is the most common presentation of Hodgkin's lymphoma. The bone involvement is seen particularly in the later stages, but very rarely in early stages of the disease. Primary osseous Hodgkin lymphoma is exceedingly rare. Here, we report a case of Primary osseous Hodgkin lymphoma in a 35-year-old male presenting with osteolytic lesions of iliac and sacral bone without other symptoms. Histopathology examination revealed Hodgkin's disease. All other investigations (including computed tomography of the chest, abdomen and pelvis, bone marrow aspiration) were negative for occult disease. Polychemotherapy was started and the symptoms resolved. The case report highlights the importance of clinical suspicion of primary Hodgkin lymphoma of the bone, especially those involving the pelvis bones. PMID:24125995

Ha-ou-nou, Fatima Zahra; Benjilali, Laila; Essaadouni, Lamiaa

2013-01-01

245

Detection of Hodgkin Transformation in a Case of Chronic Lymphocytic Leukemia by PET/CT  

PubMed Central

Richter’s transformation (RT) represents the development of high grade lymphoma, most commonly diffuse large B-cell lymphoma, in patients with chronic lymphocytic leukemia or small lymphocytic lymphoma (CLL/SLL). CLL/SLL may convert also to Hodgkin’s lymphoma, the so-called Hodgkin’s variant of Richter transformation. Histopathological proof is needed to confirm a definitive diagnosis. Patients with RT generally have a poor prognosis, with prompt recognition optimise clinical management. Whole-body PET scan with 18F-FDG can be used for detection of RT of CLL/SLL. We describe the case of 64-year-old woman with CLL/SLL who developed Hodgkin lymphoma detected with PET/CT. PMID:24963449

Y?lmaz, Sabire; Özhan, Meftune; Asa, Sertaç; Sa?er, M. Sait; Biricik, Fatih Selçuk; Halaç, Metin; Sönmezo?lu, Kerim

2014-01-01

246

Prognostic significance of serum beta-2 microglobulin level in Hodgkin lymphoma treated with ABVD-based therapy.  

PubMed

The levels of serum beta-2 microglobulin (?2MG) are determined mainly from lymphoid tissue. To examine its prognostic value in Hodgkin lymphoma (HL), we conducted a retrospective analysis. We analyzed 67 patients with HL diagnosed and treated at seven institutes of the Yokohama City University Hematology Group between 1998 and 2011. The patients included 40 males and 27 females with a median age of 41 years (range 16-81 years). The HL subtypes were nodular sclerosis classical HL in 37 patients, mixed cellular classical HL in 23, lymphocyte-rich classical HL in 6, and nodular lymphocyte-predominant HL in 1. The 4-year overall survival (OS) rate of all 67 patients was 89 %. Patients with ?2MG levels ? 2.5 mg/L (n = 18) showed inferior progression-free survival (PFS; 4-year PFS rate, 42 %) and inferior OS (4-year OS rate, 60 %) compared to patients who had ?2MG levels <2.5 mg/L (n = 49; 4-year PFS rate, 87 %; 4-year OS rate, 98 %; P < 0.001). In multivariate analysis, only a serum ?2MG level ? 2.5 mg/L was a significant adverse prognostic factor in regard to PFS (P = 0.04; relative risk 3.57). However, it was not significant prognostic factor for OS (P = 0.16) in the multivariate analysis. The serum ?2MG level at diagnosis is a useful prognostic marker in patients with HL. PMID:25142947

Nakajima, Yuki; Tomita, Naoto; Watanabe, Reina; Ishiyama, Yasufumi; Yamamoto, Eri; Ishibashi, Daisuke; Itabashi, Megumi; Koyama, Satoshi; Takahashi, Hiroyuki; Numata, Ayumi; Takasaki, Hirotaka; Kawasaki, Rika; Kuwabara, Hideyuki; Tanaka, Masatsugu; Hashimoto, Chizuko; Fujimaki, Katsumichi; Sakai, Rika; Motomura, Shigeki; Ishigatsubo, Yoshiaki

2014-09-01

247

Classical QGP : IV. Thermodynamics  

E-print Network

We construct the equation of a state of the classical QGP valid for all values of Gamma=V/K, the ratio of the mean Coulomb to kinetic energy. By enforcing the Gibbs relations, we derive the pertinent pressure and entropy densities for all Gamma. For the case of an SU(2) classical gluonic plasma our results compare well with lattice simulations. We show that the strongly coupled component of the classical QGP contributes significantly to the bulk thermodynamics across T_c.

Sungtae Cho; Ismail Zahed

2008-12-09

248

Comparison of whole-body diffusion-weighted magnetic resonance and FDG-PET/CT in the assessment of Hodgkin’s lymphoma for staging and treatment response  

PubMed Central

Computed tomography (CT), 18F-fluorodeoxyglucose positron emission tomography (FDG-PET), and hybrid FDG-PET/CT are the most commonly used diagnostic tools for the initial staging and treatment response assessment of lymphomas [1]. The aim of this report is to compare the correlations between functional imaging markers derived from FDG-PET/CT and whole-body, diffusion-weighted magnetic resonance imaging (DW-MRI) in a young patient affected by Hodgkin’s lymphoma (HL). PMID:24963346

Montoro, Juan; Laszlo, Daniele; Zing, Natalia Pin Chuen; Petralia, Giuseppe; Conte, Giorgio; Colandrea, Marzia; Martinelli, Giovanni; Preda, Lorenzo

2014-01-01

249

Expanding the Classical in Classical Sociology  

Microsoft Academic Search

If it is to become a more widely used resource at the present time, when the demand is growing for explanations of the predicament of modern western society in the wake of the events of 11 September 2001 and various similar subsequent events around the globe, classical sociology might pay more attention than it usually does to a particular set

Gary Wickham

2007-01-01

250

A clinicopathological study of nodular sclerosing Hodgkin's disease  

PubMed Central

The clinicopathological features of 29 patients with nodular sclerosing Hodgkin's disease are described. The histological appearances are those of a nodular pattern due to thick fibrous bands which encircle areas of abnormal lymphoid tissue in which a particular form of abnormal reticulum cell can be recognized. They can be further subdivided into well differentiated and poorly differentiated types; the median survival time from onset in the well differentiated type was approximately nine years and in the poorly differentiated type two years. The outstanding clinical feature of patients with the well differentiated histological pattern was repeated enlargements of various groups of lymph glands over long periods of time. Images PMID:5699072

Cross, R. M.

1968-01-01

251

Brentuximab vedotin for the treatment of patients with Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma (HL) is a relatively rare but highly curable human cancer. Because very few patients relapse and will require subsequent therapy, new drug development for HL has not been seen as a high priority by the pharmaceutical industry. Brentuximab vedotin, an antibody-drug conjugate that targets CD30 receptors, became the first drug to be approved by regulatory agencies for the treatment of HL in more than 30 years. This review summarizes the current and future directions of incorporating brentuximab vedotin in the management of patients with HL. PMID:24287065

Younes, Anas

2014-02-01

252

Esophageal obstruction 14 years after treatment for Hodgkin's disease  

SciTech Connect

The incidence of late radiation injury of the esophagus is not precisely determined but, overall, the occurrence of clinically apparent damage is infrequent. The authors report a complete esophageal obstruction in a 21-year-old man, 14 years after chemo-radiation therapy for Hodgkin's lymphoma. Although endoscopy failed to demonstrate a gross morphologic abnormality, an esophagogram detected abnormal peristalsis and stricture, and esophageal manometry coupled with dynamic isotopic study clearly demonstrated a multilevel secondary neuronal damage. Data in the literature suggest that alteration in motility is by far the most frequent radiologic manifestation. Further prospective studies will probably clarify the actual incidence of late esophageal damage after chemo-radiation therapy.

Kaplinsky, C.; Kornreich, L.; Tiomny, E.; Cohen, I.J.; Loven, D.; Zaizov, R. (Beilinson Medical Center, Petah Tiqva (Israel))

1991-08-15

253

Customized Targeted Therapy in Hodgkin Lymphoma: Hype or Hope?  

PubMed Central

Synopsis Although the majority of patients with Hodgkin lymphoma (HL) are cured with primary therapy, patients with primary refractory disease or relapse after initial treatment have poor outcomes and represent an unmet medical need. Recent advances in unraveling the biology of HL have yielded a plethora of novel targeted therapies. This review provides an overview of the data behind the hype generated by these advances and addresses the question of whether or not clinically these targeted therapies offer hope for patients with HL. PMID:24287071

Diefenbach, Catherine; Advani, Ranjana

2014-01-01

254

[Follicular non-Hodgkin lymphomas and minimal residual disease].  

PubMed

Follicular lymphomas constitute 40% of non-Hodgkin lymphomas (NHL). Most of them (85%) present the t14:18 translocation with altered expression of BCL2. The lack of clinical prognostic factors able to separate a group of patients with poor outcome have shifted the interest to the assessment of t14:18 as a molecular marker for clinical response. Moreover, the translocation site is being studied as a prognostic variable. New therapeutic modalities aimed to affect BCL2 such as the antiidiotype vaccines or antisense oligonucleotides against BCL2 have motivated great expectancy. PMID:11188937

Bruno, S

2000-01-01

255

Immunoglobulin abnormalities in malignant non-Hodgkin's lymphoma.  

PubMed

The association of monoclonal gammopathy and lymphoma was investigated in 100 consecutive, untreated cases of chronic lymphocytic leukaemia (CLL) and non-Hodgkin's lymphoma (NHL) of B-cell type, classified according to the criteria of Lukes & Collins (9). The overall incidence of monoclonal immunoglobulins (Ig) was 24%. The highest incidence (57%) was seen in plasmacytoid lymphocytic lymphoma and the lowest (7.9%) in cases of CLL. IgM was the predominant class of monoclonal Ig. It is concluded that the presence of monoclonal gammopathy in NHL reflects the stage of differentiation and maturation of the malignant B-cell clone. PMID:6433436

Economidou, J; Terzoglou, K; Anagnostou, D; Nikiforakis, E M; Papajannis, A

1984-08-01

256

Early intensification treatment approach in advanced-stage Hodgkin lymphoma.  

PubMed

The key question in advanced-stage Hodgkin lymphoma for many years now has been, should intensified chemotherapy be applied upfront or be reserved for relapsing patients. The early intensification approach with BEACOPP(escalated) (bleomycin, etoposide, doxorubicin, cyclophosphamide, vincristine, procarbazine, prednisone) aims at curing patients with first-line chemotherapy definitely. The added toxicity of this approach as compared to less intensive regimens as ABDV (doxorubicin, bleomycin, dacarbazine, vinblastine) is mainly restricted to acute haematotoxicity and gonadal damage. However, regarding efficacy, there is a meaningful survival-benefit over ABVD (10% at 5years) and the intensified first-line treatment strategy is thus rightly regarded as standard of care. PMID:24287068

Borchmann, Peter

2014-02-01

257

Chinese Biographical Database  

NSDL National Science Digital Library

Maintained by Marilyn A. Levine, Professor of Asian History at Lewis-Clark State College, this site is an effort to develop new ways to access historical database materials via the Internet. Visitors can query the database of better and lesser-known historical Chinese figures using 22 searches for specific or aggregate data questions. General search areas are: Biographical Information, Birth Year, Career, and Origin Searches; Alternate Names, Education, Family, and Youth Searches; Affiliations, Positions, and Historical Events Searches. More detailed information on individuals is available in the Reports section, which includes nine forms: Biographical Information and Career Report; Sources Report; Alternate Names Report, Education Report, Family Report, Youth Activities Report, Affiliations Report, Positions Report, and Historical Events Report. Instructions for using the site in Chinese are also provided.

1998-01-01

258

The Classics, Con Brio  

ERIC Educational Resources Information Center

Sponsored by a consortium of 30 American universities, Rome's Intercollegiate Center for Classical Studies offers a year of study to American undergraduate classics majors. Instructors are also American and normally stay only a year; teaching assistants are always ex-students of the center. Extensive field trips are an important part of the…

Hansen, James

1978-01-01

259

Revolution Coffees Classic Coffees  

E-print Network

not add a flavour to your coffee? 60p Revolution Favourites are hazelnut, vanilla, caramel, amarettoRevolution Coffees Classic Coffees All Classic Coffees are made with our bespoke blend of Fairtrade Cafetiere Coffees 1 Person Cafetiere £2.10 Pure Colombian A milder coffee with nutty undertones Costa Rica

Oakley, Jeremy

260

Classic-Ada(TM)  

NASA Technical Reports Server (NTRS)

The SPS product, Classic-Ada, is a software tool that supports object-oriented Ada programming with powerful inheritance and dynamic binding. Object Oriented Design (OOD) is an easy, natural development paradigm, but it is not supported by Ada. Following the DOD Ada mandate, SPS developed Classic-Ada to provide a tool which supports OOD and implements code in Ada. It consists of a design language, a code generator and a toolset. As a design language, Classic-Ada supports the object-oriented principles of information hiding, data abstraction, dynamic binding, and inheritance. It also supports natural reuse and incremental development through inheritance, code factoring, and Ada, Classic-Ada, dynamic binding and static binding in the same program. Only nine new constructs were added to Ada to provide object-oriented design capabilities. The Classic-Ada code generator translates user application code into fully compliant, ready-to-run, standard Ada. The Classic-Ada toolset is fully supported by SPS and consists of an object generator, a builder, a dictionary manager, and a reporter. Demonstrations of Classic-Ada and the Classic-Ada Browser were given at the workshop.

Valley, Lois

1989-01-01

261

POST?CLASSICAL NARRATION  

Microsoft Academic Search

The existence or not of a post?classical cinema has been a highly contested issue among film theorists for a very long time. This paper uses historical poetics as a method and conceptual artillery to delineate the basic principles of a new historical mode of narration that justifies the use of the term ‘post?classical’. With the help of the close textual

Eleftheria Thanouli

2006-01-01

262

Polymorphisms in methylenetetrahydrofolate reductase gene and risk of non-Hodgkin lymphoma in a multi-ethnic population.  

PubMed

An imbalance in folate metabolism can adversely affect DNA synthesis and methylation systems which can lead to susceptibility to non-Hodgkin lymphoma (NHL). Whether single nucleotide polymorphisms (SNPs) and their haplotypes in the methylenetetrahydrofolate reductase (MTHFR) are associated with NHL, remain inconclusive. We investigated the association between MTHFR C677T and A1298C SNPs and NHL risk in a population which is made up of Malay, Chinese and Indian ethnic subgroups. A total of 372 NHL patients and 722 controls were genotyped using the Sequenom MassARRAY platform. Our results of the pooled subjects failed to demonstrate significant association between the MTHFR C677T and A1298C SNPs with NHL and its subtypes. The results were in agreement with the previous meta-analyses. In the Indian ethnic subgroup however, single locus analysis of MTHFR A1298C appears to confer risk to NHL (Odds ratio (OR) 1.91, 95% confidence interval (95% CI) 1.22-3.00, P=0.006). The risk is almost doubled in homozygous carrier of MTHFR 1298CC (OR 4.03, 95% CI 1.56-10.43, P=0.004). Haplotype analysis revealed higher frequency of CC in the Indian NHL patients compared with controls (OR 1.86, 95% CI 1.18-2.93, P=0.007). There is lack of evidence to suggest an association between MTHFR C677T and A1298C with the risk of NHL in the Malays and Chinese. In the Indians however, the MTHFR A1298C confers risk to NHL. This study suggests ethnicity modifies the relationship between polymorphisms in the folate-metabolizing gene and NHL. PMID:24646728

Suthandiram, Sujatha; Gan, Gin Gin; Zain, Shamsul Mohd; Haerian, Batoul Sadat; Bee, Ping Chong; Lian, Lay Hoong; Chang, Kian Meng; Ong, Tee Chuan; Mohamed, Zahurin

2014-05-01

263

Singapore Chinese Health Study  

Cancer.gov

The current research project continues support for a residential cohort of 63,257 middle-aged and older (45 to 74 years of age) Singapore Chinese men and women accrued between 1993 and 1998. At recruitment, each study participant was interviewed in person by a trained interviewer using a structured questionnaire that emphasized current diet assessed via a validated, 165-item food frequency questionnaire.

264

Chinese foot binding.  

PubMed

Chinese foot binding embraced several modern principles of brace treatment. It was initiated in childhood while the foot was cartilaginous and moldable. Culturally, the practice attempted to shape the foot into a pointed lotus flower. The resultant cavus foot deformity was dysfunctional and crippling. This curious custom, outlawed by the Communist party, is ironically analogous in some ways to high-heel shoe wear. PMID:7567086

Berg, E E

1995-01-01

265

Chinese Space Program  

NSDL National Science Digital Library

China will soon make history by sending the first Chinese man to space. Scheduled for sometime in 2003, it will be the first step toward China's highly ambitious plans for space exploration.The China National Space Administration Web site (1) has a detailed description of the country's space policy. Aerospace China, a journal published online by the administration, has information on space development plans and other issues. The history of China's space program is recounted by the online Encyclopedia Astronautica (2). Several influential scientists and their contributions to Chinese rocketry and satellite technology are highlighted. The China Academy of Launch Vehicle Technology (3) sent the first Chinese satellite into space. Its home page showcases eight launch vehicles and offers an extensive technical description of the LM-3C model. The work of various research groups at the Shanghai Astronomical Observatory (4) deals with topics ranging from satellite dynamics to stellar astronomy. Some of the groups have details of their projects and facilities online. Another observatory studies molecular clouds and star formation (5). A large collection of its research papers are provided on its Web site. A news article from Space.com (6) discusses the forthcoming launch of the Shenzhou IV spacecraft, scheduled for later this year. It is generating considerable interest, since it is said to be identical to China's first manned spacecraft, expected to launch in 2003. Another article (7) considers China's rapidly developing space program. With the tremendous effort and lofty goals for moon bases and Mars missions, the author argues that China could eventually rival the US. Many more news stories about the Chinese space program can be found on the Dragon Space Web site (8).

Leske, Cavin.

2002-01-01

266

Indian and Chinese cosmologies reconsidered.  

PubMed

Indian and Chinese cosmic elements are five. They originate from a common source, Bralrma in Indian and Thai-chi in Chinese. The first created element is Mu = Tree, not wood, and life-form itself, immovable but moves everything else = Akaska in Indian cosmology. Dryness = Metal in Chinese, Moisture = Earth. Fire as Heat and Water as Cold, are common to both systems. PMID:3895884

Mahdihassan, S

1985-01-01

267

Computer-Mediated Materials for Chinese Character Learning.  

ERIC Educational Resources Information Center

Reviews four sets of computer-mediated materials for Chinese character learning. These include the following: Write Chinese, Chinese Characters Primer, Animated Chinese Characters, and USC Chinese Character Page. (Author/VWL)

Hsu, Hui-Mei; Gao, Liwei

2002-01-01

268

Chinese demand drives global deforestation Chinese demand drives global deforestation  

E-print Network

Chinese demand drives global deforestation Chinese demand drives global deforestation By Tansa Musa. Evidence of rampant deforestation around the globe points in one direction: booming demand in China, where buy from Amazon. com. POPULAR PAGES Rainforests Rain forests Amazon deforestation Deforestation

269

Coexistent non-Hodgkins lymphoma and ductal carcinoma breast: diagnosis on fine needle aspiration cytology.  

PubMed

Synchronous occurrance of multiple neoplastic processes is not very common, and the relationship between breast cancer with lymphoproliferative diseases is unusual as well. Furthermore, breast involvement by non-Hodgkins lymphoma is a rare event and primary breast non-Hodgkins lymphoma is even rarer. The authors take this opportunity to report a case of primary B-cell non-Hodgkins lymphoma breast occurring in association with invasive ductal carcinoma in a 47-year-old female for its rare synchronous association. PMID:21919216

Siddiqui, Farhan Asif; Maheshwari, Veena; Alam, Kiran; Jain, Anshu

2011-10-01

270

GR Classical Exploding Program  

NSDL National Science Digital Library

The GR Classical Exploding program uses Newtonian mechanics to simulate the orbits of objects that explode near a central massive object. It also shows the effective potential of the orbiting particle. The default configuration is an explosion located at r = 1. GR Classical Exploding is part of a suite of Open Source Physics programs that model aspects of General Relativity. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the gr_classical_exploding.jar file will run the program if Java is installed. Other programs provide additional visualizations. They can be found by searching ComPADRE for Open Source Physics, OSP, or General Relativity.

Christian, Wolfgang; Belloni, Mario; Cox, Anne

2008-05-27

271

Classical Mythology Directory  

NSDL National Science Digital Library

Created by Dr. Robin Mitchell-Boyask, Professor in the Department of Greek, Hebrew, and Roman Classics at Temple University, this site is primarily intended for students enrolled in the Dr. Mitchell-Boyask's summer or fall 2002 Classical Mythology course. However, the site provides a host of information on classical mythology and would be useful to anyone studying and/or interested in this area of specialization. Not only does the site contain study guides, which could be valuable material for English teachers, but it also contains information on the myths of Rome and Athens, numerous paintings and sculptures, as well as many links to other relevant sites.

Mitchell-Boyask, Robin, 1961-.

1998-01-01

272

GR Classical Program  

NSDL National Science Digital Library

The GR Classical program simulates orbits of objects around a central mass using Newtonian mechanics. It also displays a plot of the effective potential well in which the orbiting particle resides. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the gr_classical.jar file will run the program if Java is installed. GR Classical is part of a suite of Open Source Physics programs that model aspects of General Relativity. Other programs provide additional visualizations. They can be found by searching ComPADRE for Open Source Physics, OSP, or General Relativity.

Christian, Wolfgang; Belloni, Mario; Cox, Anne

2008-05-02

273

Illustrating the Classical Experiment.  

ERIC Educational Resources Information Center

Describes an activity that (1) illustrates the classical experiment as a research tool; (2) demonstrates the interplay among hypotheses, methods, and data; and (3) nurtures the excitement of a method of study. (BSR)

Zeller, Richard A.

1988-01-01

274

The Classical Bloch Equations  

E-print Network

Coherent control of a quantum mechanical two-level system is at the heart of magnetic resonance imaging, quantum information processing, and quantum optics. Among the most prominent phenomena in quantum coherent control are Rabi oscillations, Ramsey fringes and Hahn echoes. We demonstrate that these phenomena can be derived classically by use of a simple coupled harmonic oscillator model. The classical problem can be cast in a form that is formally equivalent to the quantum mechanical Bloch equations with the exception that the longitudinal and the transverse relaxation times ($T_1$ and $T_2$) are equal. The classical analysis is intuitive and well suited for familiarizing students with the basic concepts of quantum coherent control, while at the same time highlighting the fundamental differences between classical and quantum theories.

Martin Frimmer; Lukas Novotny

2014-09-26

275

Romantic / classical Science play  

E-print Network

Romantic / classical Science play Space/time [Brechtian theater] Epic theater Didactic Alienation/modernity Sex Time dilation and length contraction Historical Galileo/fictional Galileo (interpretation Shakespeare Brecht Einstein Stoppard Films Pictures Music Graphs #12;

276

Hasbun Classical Mechanics Package  

NSDL National Science Digital Library

The Hasbun Classical Mechanics Package is a self-contained Java package of OSP programs in support of the textbook: Classical Mechanics with MATLAB Applications. Classical Mechanics with MATLAB Applications is a resource for the advanced undergraduate taking introduction to classical mechanics. Filled with comprehensive examples and thorough descriptions, this text guides students through the complex topics of rigid body motion, moving coordinate systems, Lagrange's equations, small vibrations, the Euler algorithm, and much more. Step-by-step illustrations, examples and computational physics tools further enhance learning and understanding by demonstrating accessible ways of obtaining mathematical solutions. In addition to the numerous examples throughout, each chapter contains a section of MATLAB code to introduce the topic of programming scripts and their modification for the reproduction of graphs and simulations.

Hasbun, Javier

2008-06-23

277

A Classical Science Transformed.  

ERIC Educational Resources Information Center

Describes how satellites and other tools of space technology have transformed classical geodesy into the science of space geodynamics. The establishment and the activities of the French Center for Geodynamic and Astronomical Research Studies (CERGA) are also included. (HM)

Kovalevsky, Jean

1979-01-01

278

Classical gauge gravitation theory  

E-print Network

Classical gravitation theory is formulated as gauge theory on natural bundles where gauge symmetries are general covariant transformations and a gravitational field is a Higgs field responsible for their spontaneous symmetry breaking.

G. Sardanashvily

2011-10-06

279

Neuroanatomical Markers of Speaking Chinese  

PubMed Central

The aim of this study was to identify regional structural differences in the brains of native speakers of a tonal language (Chinese) compared to nontonal (European) language speakers. Our expectation was that there would be differences in regions implicated in pitch perception and production. We therefore compared structural brain images in three groups of participants: 31 who were native Chinese speakers; 7 who were native English speakers who had learnt Chinese in adulthood; and 21 European multilinguals who did not speak Chinese. The results identified two brain regions in the vicinity of the right anterior temporal lobe and the left insula where speakers of Chinese had significantly greater gray and white matter density compared with those who did not speak Chinese. Importantly, the effects were found in both native Chinese speakers and European subjects who learnt Chinese as a non-native language, illustrating that they were language related and not ethnicity effects. On the basis of prior studies, we suggest that the locations of these gray and white matter changes in speakers of a tonal language are consistent with a role in linking the pitch of words to their meaning. Hum Brain Mapp, 2009. © 2009 Wiley-Liss, Inc. PMID:19530216

Crinion, Jenny T; Green, David W; Chung, Rita; Ali, Nliufa; Grogan, Alice; Price, Gavin R; Mechelli, Andrea; Price, Cathy J

2009-01-01

280

Enliven corporate brands in Chinese  

Microsoft Academic Search

Purpose – Although the concept of branding has been considered extensively in products and services, branding in Chinese is a relatively emerging phenomenon. This paper aims to present the enlivenment of branding in Chinese within the cross-strait markets of Taiwan and Mainland China, which underlies various ideologies. Design\\/methodology\\/approach – This study primarily reviews literatures of brand and brand name translation,

Yi-Long Jaw; Ru-Yu Wang; Carol Ying-Yu Hsu

2011-01-01

281

An Introduction to Chinese Literature.  

ERIC Educational Resources Information Center

This unit will introduce secondary level students to Chinese literature. The first part of the unit discusses poetry which has always been the most highly prized form of Chinese literature. The discussion examines the "Complete Tang Poems," the "Book of Songs" compiled by Confucius, the "Songs of Chu," and the "Li Sao." Students learn about the…

Kane, Tony

282

Modelling ancient Chinese time ontology  

Microsoft Academic Search

Temporal information is one of the essential components in many domains, especially those related to history. Up until the twentieth century, the Chinese used a lunisolar calendar with the title of an Emperor and a reign period to express temporal information. When describing a historical event in Chinese history, it is inadequate to use existing time ontologies as presented in

Qing Zou; Eun G. Park

2011-01-01

283

Classical and quantum plasmas  

Microsoft Academic Search

A brief survey is given of the different theoretical approaches to the study of the low-density, high-temperature `classical' plasma and of the high-density, low-temperature `quantum' plasma. The random phase approximation, collective-variables method is shown to yield the same result as the collisionless Boltzmann equation combined with the self-consistent field method. Dynamic behaviour is studied in the classical plasma, with particular

D. Pines

1961-01-01

284

Classical-quantum semigroups  

NASA Astrophysics Data System (ADS)

An intriguing and deep analogy between classical and quantum states is revealed using the notion of positive definite function. By Bochner's theorem, (classical) positive definite functions on phase space can be obtained by taking the Fourier transform of probability measures; similarly, quantum positive definite functions are the image via the Fourier-Plancherel operator of Wigner quasi-probability distributions. Considering the basic properties of positive definite functions — classical and quantum — one is led to define a class of semigroups of operators, the so-called classical-quantum semigroups. It is then natural to wonder whether they have any physical meaning. It turns out that the classical-quantum semigroups can also be obtained by dequantizing a certain class of quantum dynamical semigroups, namely, the classical noise semigroups. This correspondence fits in a more general group-theoretical framework in which a larger class of quantum dynamical semigroups, the twirling semigroups, can be suitably dequantized. Connections with quantum information science will be briefly discussed.

Aniello, Paolo

2014-11-01

285

Obatoclax and Bortezomib in Treating Patients With Aggressive Relapsed or Recurrent Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Non-Hodgkin Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma

2013-05-01

286

Stanford study identifies early-life risk factors for non-Hodgkin lymphoma  

Cancer.gov

Factors influencing early life non-Hodgkin lymphoma (NHL) incidence include family characteristics, high fetal growth, older maternal age, low birth order, and male gender, according to a study published May 22 in the Journal of the National Cancer Institute.

287

Immune recruitment by bispecific antibodies for the treatment of Hodgkin disease  

Microsoft Academic Search

For the treatment of Hodgkin lymphoma, bispecific monoclonal antibodies (bi-mAbs) were established which recognize the Hodgkin-associated CD30 antigen with one arm and the CD3 or CD28 antigen on T lymphocytes or the CD16 antigen on natural killer (NK) cells with the second arm. The NK cell-activating !-CD16\\/CD30 antibody was able to retarget human NK cells toward CD30+ target cells and

Ligia da Costa; Christoph Renner; Frank Hartmann; Michael Pfreundschuh

2000-01-01

288

Prognostic importance of DNA flow cytometry in non-Hodgkin's lymphomas  

Microsoft Academic Search

Eighty one cases of non-Hodgkin's lymphoma were examined by DNA flow cytometry, using fixed embedded histological tissue. The frequency of detection of DNA aneuploidy and the values for S phase fractions depended on the histological subtype and grade of lymphoma. Twenty two of the patients with low grade centroblastic\\/centrocytic non-Hodgkin's lymphoma had repeat biopsies. Eleven of these patients remained histologically

J C Macartney; R S Camplejohn; J Alder; M G Stone; G Powell

1986-01-01

289

Cigarette Smoking and Risk of Hodgkin's Disease: A Population-based Case-Control Study  

Microsoft Academic Search

Previous reports offer limited support for an association between cigarette smoking and Hodgkin's disease. The authors investigated dose-response effects for smoking in relation to the risk of Hodgkin's disease using data from the Selected Cancers Study. Cases (n = 343) were men aged 32-60 years identified from eight US population-based cancer registries in 1984-1988. Controls (n = 1,910) were men

Nathaniel C. Briggs; H. Irene Hall; Edward A. Brann; Cynthia J. Moriarty; Robert S. Levine

290

Antidepressant Medication Use and Non-Hodgkin's Lymphoma Risk: No Association  

Microsoft Academic Search

Animal and human studies have suggested that antidepressant medications may be associated with several cancers. The authors evaluated the association between antidepressant medication use and the risk of non- Hodgkin's lymphoma using a Canadian population-based case-control study, the National Enhanced Cancer Surveillance Study. Non-Hodgkin's lymphoma cases (n = 638) diagnosed in 1995-1996 were identified using the Ontario Cancer Registry, and

Saira Bahl; Michelle Cotterchio; Nancy Kreiger; Neil Klar

291

Is Chinese Software Engineering Professionalizing or Not?: Specialization of Knowledge, Subjective Identification and Professionalization  

ERIC Educational Resources Information Center

Purpose: This paper aims to discuss the challenge for the classical idea of professionalism in understanding the Chinese software engineering industry after giving a close insight into the development of this industry as well as individual engineers with a psycho-societal perspective. Design/methodology/approach: The study starts with the general…

Yang, Yan

2012-01-01

292

Computerized image analysis of sister chromatid exchanges in Chinese hamster ovary cells  

Microsoft Academic Search

In this paper we show that sister chromatid exchanges (SCE) can be analysed by computer-supported determination of areas and shapes of darkly stained chromatid sections. In combination with appropriate statistical analyses, our method leads to measurements of SCE frequencies in neocarzinostatin-treated Chinese hamster ovary cells which are nearly as precise as the ones obtained by classical microscopical analyses. We discuss

C Schunck; G Obe

1997-01-01

293

What Should American-Born Chinese Children Learn?  

ERIC Educational Resources Information Center

This paper discusses the teaching of Chinese to both students with Chinese background and students with non-Chinese background. It is suggested that students with a Chinese background be separated from those without a Chinese background in order not to discourage the latter group from studying Chinese. Chinese background students should be taught…

Chang, Shirley

294

Coming This Fall: Common Chinese Medicinal Plants  

E-print Network

. In addition, the knowledge of traditional Chinese medicine and Herb uses, systems and methods for Chinese;2 2. To introduce students the philosophy of Traditional Chinese Medicine and herbal uses. 3Coming This Fall: Common Chinese Medicinal Plants Identification, Classification and Application

Weiblen, George D

295

Biotech's Chinese connection  

SciTech Connect

Hong Kong last month opened the Hong Kong Institute of Biotechnology (HKIB), a nonprofit R and D center. By combining Chinese expertise in medicinal compounds and cell culturing with Western technical and marketing skills, the institute hopes to develop products that could be licensed to Hong Kong or Western films. The institute is also developing experimental cell lines and making genetically engineered versions of promising compounds, taking advantage of the cell-culturing and cloning skills that are highly developed on the mainland. The Shanghai contingent is already involved in one of the institute's projects, an effort to transfer human genes into mouse fibroblasts to create cell lines for research on the molecular mechanisms of learning and memory. Other Chinese researchers are taking part in HKIB's joint venture with Syntex, which was signed last April. The mainland researchers extract candidate medicinal compounds from plants and microorganisms. In Hong Kong, the compounds are tested for their effects on neurotransmitter receptors, while Syntex scientists in Palo Alto study how the same compounds affect enzyme activity and whole cells.

Hodgson, G.

1992-03-27

296

Chinese Armillary Spheres  

NASA Astrophysics Data System (ADS)

The armillary sphere was perhaps the most important type of astronomical instrument in ancient China. It was first invented by Luoxia Hong in the first century BC. After Han times, the structure of the armillary sphere became increasingly sophisticated by including more and more rings representing various celestial movements as recognized by the Chinese astronomers. By the eighth century, the Chinese armillary sphere consisted of three concentric sets of rings revolving on the south-north polar axis. The relative position of the rings could be adjusted to reflect the precession of the equinoxes and the regression of the Moon's nodes along the ecliptic. To counterbalance the defect caused by too many rings, Guo Shoujing from the late thirteenth century constructed the Simplified Instruments which reorganized the rings of the armillary sphere into separate instruments for measuring equatorial coordinates and horizontal coordinates. The armillary sphere was still preserved because it was a good illustration of celestial movements. A fifteenth-century replica of Guo Shoujing's armillary sphere still exists today.

Sun, Xiaochun

297

Disseminated toxoplasmosis in a patient with non-Hodgkin lymphoma.  

PubMed

Toxoplasmosis is a well-recognized opportunistic disease in HIV-infected individuals that is caused by the reactivation of a previous infection, primarily in the central nervous system, during profound immunodeficiency. Toxoplasmosis has been described more rarely in patients with cancer and chemotherapy. We report a case of a patient with a history of chemotherapy for non-Hodgkin lymphoma who developed pain and progressive paresthesia of the right arm 6 weeks after remission. Relapsing lymphoma was suspected, and steroid and radiation treatment were initiated, but the patient died 5 days later due to multiple organ failure. Autopsy revealed disseminated toxoplasmosis. This case illustrates that toxoplasmosis should be suspected in patients with neoplastic disease, especially lymphomas, who present with unexplained neurologic, pulmonary, or febrile symptoms during or after chemotherapy. PMID:19499181

Herold, M A; Kühne, R; Vosberg, M; Ostheeren-Michaelis, S; Vogt, P; Karrer, U

2009-12-01

298

Rituximab in the treatment of non-Hodgkin’s lymphoma  

PubMed Central

Besides traditional cytostatic drugs the introduction of monoclonal antibodies has substantially influenced current treatment concepts of non-Hodgkin’s lymphoma (NHL). Rituximab, a monoclonal anti-CD20 chimeric antibody, now has been widely evaluated in the various B-cell lymphatic neoplasms. Large phase III studies helped to prove the value of this drug in follicular lymphoma as part of induction or relapse treatment as well as maintenance treatment. The addition of rituximab to the well established CHOP regimens has increased achievable cure rates in diffuse large cell lymphoma, and this combination is now accepted worldwide as standard of care. Although conflicting results are available, rituximab is widely used for the treatment of mantle cell lymphoma. For the less frequent lymphoma entities phase 2 studies show a considerable efficiency for most of these B-NHL variants. Current research focuses on combined chemoimmunotherapy approaches, optimization of dosing regimens, and combination with novel agents. PMID:19707443

Hauptrock, Beate; Hess, Georg

2008-01-01

299

[Molecular target therapy for non-Hodgkin lymphoma].  

PubMed

Non-Hodgkin lymphomas(NHL) encompass various types of lymphoid neoplasms with different biological behavior. Comprehensive genomic analysis identifies novel mutation and signaling pathways in various tumors, which leads to rational approaches in cancer therapy. Molecular target therapy is a new approach focusing on specific protein or signaling pathways. Molecules of signaling pathways of B-cell receptor, PI3K/Akt/mTOR and NF-kappaB are rational target, and many new drugs targeting the pathways are developing in various subtypes of lymphoma. Monoclonal and novel conjugated antibodies for cell surface proteins, epigenetic modulators and immunomodulatory agents also show promising clinical activities. This review will focus on the new molecular target drugs and their activity in NHL. PMID:25016812

Kato, Harumi; Kinoshita, Tomohiro

2014-06-01

300

Brentuximab vedotin: first-line agent for advanced Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma (HL) is characterized by malignant Reed-Sternberg cells which express CD30. Current National Comprehensive Cancer Network guidelines for patients with advanced HL (stage III/IV disease) recommend adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD), or escalated bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine, procarbazine, and prednisone (BEACOPP) as first-line regimens. ABVD appears to be as effective, with fewer side effects, as escalated BEACOPP. Escalated BEACOPP leads to a greater progression-free survival but no difference in overall survival. Recent advancements in technology have enabled an exciting shift to molecular-targeted cancer therapy. Brentuximab vedotin, a CD30-directed antibody conjugate, specifically targets malignant HL cells. It is approved by the Food and Drug Administration for the treatment of systemic anaplastic large-cell lymphoma and refractory HL that has progressed after autologous stem cell transplant, or after two prior multiagent chemotherapy regimens among patients ineligible to receive a transplant. PMID:24023323

Cao, Huynh; Yamamoto, Kenneth; Yang, Li-Xi; Weber, Robert

2013-09-01

301

Primary colorectal non-Hodgkin's lymphoma in a retropositive patient.  

PubMed

A 43-year-old man known case of retropositive illness presented with abdomen pain of 15 days and loose stools for 10 days. Loose stools were foul smelling and blood stained. The patient was a known case of type 2 diabetes and retroviral illness on highly active antiretroviral therapy (HAART). General physical examination was normal. On examination an irregular mass was palpable in the right iliac fossa and right flank. The mass was hard in nature; irregular with restricted mobility. There was no palpable liver or spleen. CT of the abdomen and pelvis revealed a well-defined heterogeneously enhancing hypodense mass lesion measuring 16 × 11.7 × 12 cm involving the ileocaecal region and extending medially and inferiorly to sigmoid colon and rectum. A colonoscopy showed a proliferative highly vascular mass 15 cm from anal verge at the rectosigmoid junction. Histopathology revealed sheets of neoplastic lymphoid cells in rectal wall suggestive of non-Hodgkins lymphoma. PMID:24014336

Sadhu, Sakshi; Prabhu, Raghunath; Natarajan, Arjun; Vaidya, Kuldeep

2013-01-01

302

Hodgkin Disease—An Ever-Evolving Therapy  

PubMed Central

Therapy of Hodgkin lymphoma (HL) is a rapidly changing field due to plenty of currently emerging data. Treatment approaches are currently based on tailoring of therapy in order to achieve a maximal response with minimal toxicity. Since the median age of HL patients is 33 years and their prospective life expectancy of another half a century, a major emphasis needs to be put on dramatic reduction of later toxicity. The assessment of the treatment effect should be based not only on progression-free survival, but should include evaluation of cardiac toxicity, secondary neoplasms, and fertility in the long-term follow-up. The ancient principle “first do no harm” should be central in HL therapy. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. PMID:25386345

Dann, Eldad J.

2014-01-01

303

Non-Hodgkin's lymphomas, version 4.2014.  

PubMed

Non-Hodgkin's lymphomas (NHL) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Mantle cell lymphoma (MCL) accounts for approximately 6% of all newly diagnosed NHL cases. Radiation therapy with or without systemic therapy is a reasonable approach for the few patients who present with early-stage disease. Rituximab-based chemoimmunotherapy followed by high-dose therapy and autologous stem cell rescue (HDT/ASCR) is recommended for patients presenting with advanced-stage disease. Induction therapy followed by rituximab maintenance may provide extended disease control for those who are not candidates for HDT/ASCR. Ibrutinib, a Bruton tyrosine kinase inhibitor, was recently approved for the treatment of relapsed or refractory disease. This manuscript discusses the recommendations outlined in the NCCN Guidelines for NHL regarding the diagnosis and management of patients with MCL. PMID:25190696

Zelenetz, Andrew D; Gordon, Leo I; Wierda, William G; Abramson, Jeremy S; Advani, Ranjana H; Andreadis, C Babis; Bartlett, Nancy; Byrd, John C; Czuczman, Myron S; Fayad, Luis E; Fisher, Richard I; Glenn, Martha J; Harris, Nancy Lee; Hoppe, Richard T; Horwitz, Steven M; Kelsey, Christopher R; Kim, Youn H; Krivacic, Susan; LaCasce, Ann S; Nademanee, Auayporn; Porcu, Pierluigi; Press, Oliver; Rabinovitch, Rachel; Reddy, Nishitha; Reid, Erin; Saad, Ayman A; Sokol, Lubomir; Swinnen, Lode J; Tsien, Christina; Vose, Julie M; Yahalom, Joachim; Zafar, Nadeem; Dwyer, Mary; Sundar, Hema

2014-09-01

304

Non-Hodgkin's lymphomas, version 2.2014.  

PubMed

Non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of lymphoproliferative disorders originating in B lymphocytes, T lymphocytes, or natural killer cells. Follicular lymphoma (FL) is the most common subtype of indolent NHL, accounting for approximately 22% of all newly diagnosed cases of NHL. The incorporation of rituximab to chemotherapy regimens has become a widely accepted standard of care for first-line therapy for patients with FL. Maintenance and consolidation therapy with rituximab and radioimmunotherapy have also been associated with improved progression-free survival in patients experiencing response to first-line therapy. Despite therapeutic advances that have improved outcomes, FL is generally considered a chronic disease characterized by multiple recurrences with current therapies. This manuscript discusses the recommendations outlined in the NCCN Guidelines for the diagnosis and management of patients with FL. PMID:24925202

Zelenetz, Andrew D; Gordon, Leo I; Wierda, William G; Abramson, Jeremy S; Advani, Ranjana H; Andreadis, C Babis; Bartlett, Nancy; Bellam, Naresh; Byrd, John C; Czuczman, Myron S; Fayad, Luis E; Fisher, Richard I; Glenn, Martha J; Harris, Nancy Lee; Hoppe, Richard T; Horwitz, Steven M; Kelsey, Christopher R; Kim, Youn H; Krivacic, Susan; LaCasce, Ann S; Nademanee, Auayporn; Porcu, Pierluigi; Press, Oliver; Rabinovitch, Rachel; Reddy, Nishitha; Reid, Erin; Sokol, Lubomir; Swinnen, Lode J; Tsien, Christina; Vose, Julie M; Yahalom, Joachim; Zafar, Nadeem; Dwyer, Mary; Sundar, Hema

2014-06-01

305

Bone marrow necrosis in a girl with Hodgkin's disease.  

PubMed

Bone marrow necrosis (BMN) is a rare finding in children with malignancy occurring most commonly in children with acute lymphoblastic leukemia. This article describes the first case of a girl who developed BMN during treatment for Hodgkin's disease. During the second cycle of chemotherapy, she experienced sudden profound bone pain in the lumbosacral region associated with elevated levels of lactate dehydrogenase (LDH), fibrin degradation products (D-Dimer), and alkaline phosphatase as well as pancytopenia and leukoerythroblastosis. MRI studies showed multiple confluent areas with low signal intensity and rim contrast enhancement in all vertebral bodies. Bone marrow biopsy revealed focal necrosis within hypocellular bone marrow. The patient responded quickly to symptomatic treatment with analgetics and heparin; however, elevations of LDH and D-Dimer persisted for 1.5 and 8 months, respectively. Clinicians should be aware of this rare condition to establish the diagnosis and to continue oncologic treatment as early as possible. PMID:22773298

Lackner, Herwig; Strenger, Volker; Sovinz, Petra; Beham-Schmid, Christine; Pilhatsch, Alexander; Benesch, Martin; Schwinger, Wolfgang; Ulreich, Raphael; Schmidt, Sandrin; Urban, Christian

2012-09-01

306

Advances and application of radioimmunotherapy in non-Hodgkin lymphoma  

PubMed Central

The activity of radio-immuno conjugate in Non-Hodgkin Lymphoma (NHL) has resulted in FDA approval of two antibodies, Y90 Ibritumomab tiuxetan and I131 tositumomab. Both these agents target CD20, a receptor widely expressed in B-Cell NHL. These immunoconjugates deliver their radioactive payload to the malignant clone in the bone marrow and lymph node. Their use has been associated with modest improvement in survival end points among several lymphoma histologies. The promising effect on disease control as well as their efficacy in disease relapse is encouraging in low grade lymphoma. Radioimmunotherapy (RIT) is increasingly being explored in the setting of consolidation as well as conditioning regimens prior to stem cell transplantation. Here, we summarize the clinical use, complications and future applications of RIT in NHL. PMID:22762027

Stevens, Patrick L; Oluwole, Olalekan; Reddy, Nishitha

2012-01-01

307

Hodgkin disease-an ever-evolving therapy.  

PubMed

Therapy of Hodgkin lymphoma (HL) is a rapidly changing field due to plenty of currently emerging data. Treatment approaches are currently based on tailoring of therapy in order to achieve a maximal response with minimal toxicity. Since the median age of HL patients is 33 years and their prospective life expectancy of another half a century, a major emphasis needs to be put on dramatic reduction of later toxicity. The assessment of the treatment effect should be based not only on progression-free survival, but should include evaluation of cardiac toxicity, secondary neoplasms, and fertility in the long-term follow-up. The ancient principle "first do no harm" should be central in HL therapy. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. PMID:25386345

Dann, Eldad J

2014-10-01

308

Advanced hodgkin lymphoma: a new era of therapy.  

PubMed

Therapy of advanced Hodgkin lymphoma (HL) is a rapidly changing field due to a lot of currently emerging data. Treatment approaches are presently based on either the Kairos principle of giving aggressive therapy upfront and considering de-escalation of therapy if the interim PET/CT is negative or the Chronos principle of starting with ABVD followed by escalation of therapy for patients with positive interim PET/CT. The International Prognostic Score (IPS) is still valid for decision-making regarding the type of initial therapy, since patients with a high score do have an inferior progression free survival (PFS) with ABVD compared to those with a low score. Escalated BEACOPP administered upfront improves PFS; however, increase in the overall survival (OS) has not been confirmed yet, and this therapy is accompanied by elevated toxicity and fertility impairment. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. PMID:25237476

Dann, Eldad J

2014-01-01

309

An adult patient with Nijmegen Breakage Syndrome and Hodgkin's Lymphoma  

PubMed Central

Background Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder characterized by immune deficiency, microcephaly, mental retardation and a disposition for the development of hematological malignancies. So far, mostly pediatric patients have been described, since the underlying condition is often fatal before adulthood. Many patients diagnosed with Hodgkin lymphoma (HL) due to this DNA repair defect receive reduced treatment followed by early progression and fatal outcome. Case presentation We describe here a 26-year old male caucasian patient with NBS who presented with multi organ failure due to HL. Immediate intensive chemotherapy lead to complete remission and reversed organ failure. Conclusion We show that application of standard chemotherapy can lead to long-term disease free survival in patients with a DNA repair disorder. Furthermore, we describe here, to the best of our knowledge, the first adult patient with NBS and HL. PMID:24428841

2014-01-01

310

Expression of CD95 antigen and Bcl-2 protein in non-Hodgkin's lymphomas and Hodgkin's disease.  

PubMed Central

CD95 (APO-1/Fas) is a member of the superfamily that includes the nerve growth factor and tumor necrosis factor receptors, OX40, CD27, CD30, and CD40. Present on a minority of resting blood lymphocytes, CD95 expression is upregulated on activated T and B lymphocytes and natural killer cells, where binding of the antigen by anti-Fas and anti-APO-1 antibodies has been shown to induce apoptosis. This CD95-mediated apoptosis is at least partially inhibited by expression of the Bcl-2 protooncogene. To evaluate possible roles of CD95 and Bcl-2 in growth regulation of lymphoid neoplasms, we studied by immunohistochemistry the expression of CD95 and Bcl-2 in 67 B- and 5 T-cell lymphomas, and 10 cases of Hodgkin's disease. In all, 29 B and 2 T cell lymphomas, and 9 cases of Hodgkin's disease expressed CD95. Compared with diffuse large B-cell and Burkitt-like lymphomas, lowgrade B-cell lymphomas more frequently expressed CD95 (52% versus 26%; P < .005). None of the B-cell small lymphocytic lymphomas or mantle cell lymphomas expressed CD95, whereas the majority of follicle center lymphomas, extranodal marginal zone B-cell lymphomas, and immunocytomas were CD95+. Of the 29 CD95+ B-cell lymphomas, only 33% of the high-grade group coexpressed Bcl-2, compared with 87% of the low-grade group (P < .04). Two of three peripheral T-cell lymphomas--including one anaplastic large cell lymphoma--expressed CD95. Staining for CD95 was seen in 9 of 10 cases of Hodgkin's disease. The infrequent expression of CD95 in high-grade B-cell lymphomas suggests an association between loss of CD95 expression/function and a more aggressive tumor grade. Whereas frequent coexpression of Bcl-2 with CD95 may protect low-grade B-cell lymphomas against CD95-mediated apoptosis, in the high-grade group such coexpression is infrequent, and other regulators besides Bcl-2 may be involved in modulating the apoptosis signal delivered by CD95. Images Figure 1 Figure 2 PMID:8774139

Nguyen, P. L.; Harris, N. L.; Ritz, J.; Robertson, M. J.

1996-01-01

311

Hodgkin's Lymphoma in Older Patients: an Orphan Disease?  

PubMed

Hodgkin Lymphoma HL can be cured in the large majority of younger patients, but prognosis for older patients, especially those with advanced-stage disease, has not improved substantially. The percentage of HL patients aged over 60 ranges between 15% and 35%. A minority of them is enrolled into clinical trials. HL in the elderly have some specificities: more frequent male sex, B-symptoms, advanced stage, sub diaphragmatic presentation, higher percentage of mixed cellularity, up to 50% of advanced cases associated to EBV. Very old age (>70) and comorbidities are factor of further worsening prognosis. Like in younger patients, ABVD is the most used protocol, but treatment outcome remains much inferior with more frequent, severe and sometimes specific toxicities. Few prospective studies with specific protocols are available. The main data have been published by the Italian Lymphoma Group with the VEPEMB schedule and the German Hodgkin Study Group with the PVAG regimen. Recently, the Scotland and Newcastle Lymphoma Study Group published the SHIELD program associating a prospective phase 2 trial with VEPEMB and a prospective registration of others patients. Patients over 60y with early-stage disease received three cycles plus radiotherapy and had 81% of 3-year overall survival (OS). Those with advanced-stage disease received six cycles, with 3-year OS of 66%. The role of geriatric and comorbidity assessment in the treatment's choice for HL in the elderly is a major challenge. The combination of loss of activities of daily living combined with the age stratification more or less 70y has been shown as a simple and effective survival model. Hopes come from promising new agents like brentuximab-vedotin (BV) a novel antibody-drug conjugate. The use of TEP to adapt the combination of chemotherapy and radiotherapy according to the metabolic response could also be way for prospective studies. PMID:25045458

Thyss, Antoine; Saada, Esma; Gastaud, Lauris; Peyrade, Frédéric; Re, Daniel

2014-01-01

312

Classical Dynamical Localization  

NASA Astrophysics Data System (ADS)

We consider classical models of the kicked rotor type, with piecewise linear kicking potentials designed so that momentum changes only by multiples of a given constant. Their dynamics display quasilocalization of momentum, or quadratic growth of energy, depending on the arithmetic nature of the constant. Such purely classical features mimic paradigmatic features of the quantum kicked rotor, notably dynamical localization in momentum, or quantum resonances. We present a heuristic explanation, based on a classical phase space generalization of a well-known argument, that maps the quantum kicked rotor on a tight-binding model with disorder. Such results suggest reconsideration of generally accepted views that dynamical localization and quantum resonances are a pure result of quantum coherence.

Guarneri, Italo; Casati, Giulio; Karle, Volker

2014-10-01

313

Classical dynamical localization.  

PubMed

We consider classical models of the kicked rotor type, with piecewise linear kicking potentials designed so that momentum changes only by multiples of a given constant. Their dynamics display quasilocalization of momentum, or quadratic growth of energy, depending on the arithmetic nature of the constant. Such purely classical features mimic paradigmatic features of the quantum kicked rotor, notably dynamical localization in momentum, or quantum resonances. We present a heuristic explanation, based on a classical phase space generalization of a well-known argument, that maps the quantum kicked rotor on a tight-binding model with disorder. Such results suggest reconsideration of generally accepted views that dynamical localization and quantum resonances are a pure result of quantum coherence. PMID:25379918

Guarneri, Italo; Casati, Giulio; Karle, Volker

2014-10-24

314

Variant t(2;11)(p11;q13) associated with the IgK-CCND1 rearrangement is a recurrent translocation in leukemic small-cell B-non-Hodgkin lymphoma  

Microsoft Academic Search

Classical t(11;14)(q13;q32) involving IGH-CCND1 is typically associated with aggressive CD5-positive mantle cell lymphoma (MCL). Recently, we identified the IGK variant of this translocation, t(2;11)(p11;q13), in three patients with a leukemic small-cell B-non-Hodgkin lymphoma. In all cases, rearrangements of the IGK and CCND1 genes were demonstrated by fluorescence in situ hybridization. Moreover, we mapped the 11q13 breakpoint of this variant translocation

I Wlodarska; P Meeus; M Stul; L Thienpont; E Wouters; L Marcelis; H Demuynck; J-L Rummens; V Madoe; A Hagemeijer

2004-01-01

315

Nitrogen in Chinese coals  

USGS Publications Warehouse

Three hundred and six coal samples were taken from main coal mines of twenty-six provinces, autonomous regions, and municipalities in China, according to the resource distribution and coal-forming periods as well as the coal ranks and coal yields. Nitrogen was determined by using the Kjeldahl method at U. S. Geological Survey (USGS), which exhibit a normal frequency distribution. The nitrogen contents of over 90% Chinese coal vary from 0.52% to 1.41% and the average nitrogen content is recommended to be 0.98%. Nitrogen in coal exists primarily in organic form. There is a slight positive relationship between nitrogen content and coal ranking. ?? 2011 Science Press, Institute of Geochemistry, CAS and Springer Berlin Heidelberg.

Wu, D.; Lei, J.; Zheng, B.; Tang, X.; Wang, M.; Hu, J.; Li, S.; Wang, B.; Finkelman, R.B.

2011-01-01

316

Chinese Historical Society  

NSDL National Science Digital Library

Archaeological digs can tell us much about ancient civilizations, but what about more recent periods of human habitation? This fine collection from the USC Digital Library presents over 1,100 images of artifacts excavated from two sites in Southern California. The Chinatown section features 1,040 color images of artifacts from the original Los Angeles Chinatown. These items were recovered during the construction of the Metro Rail Red Line by the Los Angeles County Metropolitan Transportation Authority. The online collection includes photos of wine bowls, ink stone boxes, and other fragments of items from daily household life. The second segment includes items excavated in 1992 from an old adobe structure in Santa Barbara that housed a Chinese laundry from the mid 1880s to 1905. The collection can be searched via keyword, and it is quite a resource for historians, archaeologists, and others.

2012-02-03

317

Recommendations for initial evaluation, staging, and response assessment of Hodgkin and non-Hodgkin lymphoma: the Lugano classification.  

PubMed

The purpose of this work was to modernize recommendations for evaluation, staging, and response assessment of patients with Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL). A workshop was held at the 11th International Conference on Malignant Lymphoma in Lugano, Switzerland, in June 2011, that included leading hematologists, oncologists, radiation oncologists, pathologists, radiologists, and nuclear medicine physicians, representing major international lymphoma clinical trials groups and cancer centers. Clinical and imaging subcommittees presented their conclusions at a subsequent workshop at the 12th International Conference on Malignant Lymphoma, leading to revised criteria for staging and of the International Working Group Guidelines of 2007 for response. As a result, fluorodeoxyglucose (FDG) positron emission tomography (PET)–computed tomography (CT) was formally incorporated into standard staging for FDG-avid lymphomas. A modification of the Ann Arbor descriptive terminology will be used for anatomic distribution of disease extent, but the suffixes A or B for symptoms will only be included for HL. A bone marrow biopsy is no longer indicated for the routine staging of HL and most diffuse large B-cell lymphomas. However, regardless of stage, general practice is to treat patients based on limited (stages I and II, nonbulky) or advanced (stage III or IV) disease, with stage II bulky disease considered as limited or advanced disease based on histology and a number of prognostic factors. PET-CT will be used to assess response in FDG-avid histologies using the 5-point scale. The product of the perpendicular diameters of a single node can be used to identify progressive disease. Routine surveillance scans are discouraged. These recommendations should improve evaluation of patients with lymphoma and enhance the ability to compare outcomes of clinical trials. PMID:25113753

Cheson, Bruce D; Fisher, Richard I; Barrington, Sally F; Cavalli, Franco; Schwartz, Lawrence H; Lister, T Andrew

2014-09-20

318

Careers in the Classics  

ERIC Educational Resources Information Center

America's few Black classics professors have overcome contempt and criticism to contribute a unique perspective to the study of the ancient world. Dr. Patrice Rankine, an associate professor from Purdue University, has grown used to the irony. As one of the few Black classicists teaching at an American university, he has drawn plenty of skepticism…

Lum, Lydia

2005-01-01

319

Classics and the Future.  

ERIC Educational Resources Information Center

This paper attempts to show the need for Classicists currently in the field to begin long-range planning for the field of Classics. Classicists have been unable or unwilling to plan solid actions, waiting instead to react, or respond, to educational trends and problems. While the entire junior and community colleges movement was growing,…

Wolverton, Robert E.

320

Classical Dark Matter  

E-print Network

Classical particle-like solutions of field equations such as general relativity, could account for dark matter. Such particles would not interact quantum mechanically and would have negligible interactions apart from gravitation. As a relic from the big bang, they would be a candidate for cold dark matter consistent with observations.

Mark J Hadley

2007-01-17

321

The Classics as Humanities  

ERIC Educational Resources Information Center

Classics may be taught as humanities to help students understand both the ancient and modern worlds. Literature taught in translation can acquaint students with these works and illuminate modern literature. Visual aids such as slides, photos, post cards, sculpture reproductions and maps may awaken student interest. (CK)

Norton, Mary E.

1975-01-01

322

Classical Mythology. Fourth Edition.  

ERIC Educational Resources Information Center

Designed for students with little or no background in classical literature, this book introduces the Greek and Roman myths of creation, myths of the gods, Greek sagas and local legends, and presents contemporary theories about the myths. Drawing on Homer, Hesiod, Pindar, Vergil, and others, the book provides many translations and paraphrases of…

Morford, Mark P. O.; Lenardon, Robert J.

323

Extended symmetrical classical electrodynamics  

Microsoft Academic Search

In this paper, we discuss a modification of classical electrodynamics in which ``ordinary'' point charges are absent. The modified equations contain additional terms describing the induced charges and currents. The densities of the induced charges and currents depend on the vector k and the vectors of the electromagnetic field, E and B . It is shown that the vectors E

A. V. Fedorov; E. G. Kalashnikov

2008-01-01

324

Introduction Classical Field Theory  

E-print Network

Introduction Classical Field Theory Locally Covariant Quantum Field Theory Renormalization Time evolution Conclusions and outlook Locality and Algebraic Structures in Field Theory Klaus Fredenhagen II¨utsch and Pedro Lauridsen Ribeiro) Klaus Fredenhagen Locality and Algebraic Structures in Field Theory #12

Baer, Christian

325

Classicism and Romanticism.  

ERIC Educational Resources Information Center

Describes one teacher's methods for introducing to secondary English students the concepts of Classicism and Romanticism in relation to pictures of gardens, architecture, music, and literary works. Outlines how the unit leads to a writing assignment based on collected responses over time. (HB)

Huddleston, Gregory H.

1993-01-01

326

Classics in What Sense?  

ERIC Educational Resources Information Center

They seem the perfect bookends for the social psychologist's collection of "classics" of the field. Two volumes, nearly identical in shape and weight and exactly a century old in 2008--each professing to usher "social psychology" into the world as they both place the hybrid expression square in their titles but then proceed to stake out the field…

Camic, Charles

2008-01-01

327

Classics in Translation.  

ERIC Educational Resources Information Center

Increasing interest over the last twenty years in quality Greek and Latin translations seems to be primarily a reflection of the "paperback revolution." Figures and trend reports from various publishers illustrate the burgeoning numbers of classical works in translation. This new availability has enabled students of literature, history, political…

Norton, Mary E.

1968-01-01

328

Chinese Constellations and Star Maps  

NASA Astrophysics Data System (ADS)

Star observations can be traced back to as early as the twenty-third century BC in ancient China. By the fifth century BC, the Chinese had named the 28 asterisms that formed the basic reference points for the Chinese equatorial coordinate system. By the first century BC, the Chinese had developed a unique system of constellations that reflected Chinese cosmological ideas with the central theme of the correlation between Heaven and Man. Star charts have been discovered on tomb ceilings dating back to Han times. But most of them are illustrative in their presentation of stars. The Dunhuang star maps from the ninth century, the star maps in the Xin yixiang fa yao of the eleventh century, and the Suzhou Astronomical Planisphere of the thirteenth century are examples of precise star maps from ancient China.

Sun, Xiaochun

329

Mathematics of the Chinese Calendar  

NSDL National Science Digital Library

A mathematics professor from UC Berkeley, currently on sabbatical and at the National University of Singapore, has posted this information about the Mathematics of the Chinese Calendar. Professor Helmer Aslaksen gives some background on why he has developed this webpage, noting that "Chinese New Year is the main holiday of the year for more than one quarter of the world's population; very few people, however, know how to compute its date." Having little success in finding any information on the rules of the Chinese Calendar, he decided to work it out himself. Posted here are some of his papers on the Mathematics of the Chinese Calendar, along with an overall explanation of his method of calculation and several astronomical Java Applets and Animations to help explain the motion of the Earth and the Sun. His website on Heavenly Mathematics provides further ideas on ways to teach astronomy in a cultural context.

330

Quantum particles from classical statistics  

E-print Network

Quantum particles and classical particles are described in a common setting of classical statistical physics. The property of a particle being "classical" or "quantum" ceases to be a basic conceptual difference. The dynamics differs, however, between quantum and classical particles. We describe position, motion and correlations of a quantum particle in terms of observables in a classical statistical ensemble. On the other side, we also construct explicitly the quantum formalism with wave function and Hamiltonian for classical particles. For a suitable time evolution of the classical probabilities and a suitable choice of observables all features of a quantum particle in a potential can be derived from classical statistics, including interference and tunneling. Besides conceptual advances, the treatment of classical and quantum particles in a common formalism could lead to interesting cross-fertilization between classical statistics and quantum physics.

C. Wetterich

2010-02-11

331

Alisertib in Combination With Vorinostat in Treating Patients With Relapsed or Recurrent Hodgkin Lymphoma, B-Cell Non-Hodgkin Lymphoma, or Peripheral T-Cell Lymphoma  

ClinicalTrials.gov

Adult B Acute Lymphoblastic Leukemia; Adult T Acute Lymphoblastic Leukemia; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Chronic Lymphocytic Leukemia; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; T-Cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2015-01-23

332

The classical geometrization electromagnetism  

E-print Network

Following the line of the history, if by one side the electromagnetic theory was consolidated on the 19th century, the emergence of the special and the general relativity theories on the 20th century opened possibilities of further developments, with the search for the unification of the gravitation and the electromagnetism on a single unified theory. Some attempts to the geometrization of the electromagnetism emerged in this context, where these first models resided strictly on a classical basis. Posteriorly, they were followed by more complete and embracing quantum field theories. The present work reconsiders the classical viewpoint, with the purpose of showing that in a first order of approximation the electromagnetism constitutes a geometric structure aside other phenomena as gravitation. Even though being limited, the model is consistent and offers the possibility of an experimental test of validity.

C. A. Duarte

2015-02-11

333

Classical Language Instruction Project  

NSDL National Science Digital Library

Developed by Christian Wildberg at Princeton University, the Classical Language Instruction Project is designed to function as a resource for college undergraduates hoping to gain some insight into the pronunciation and elocution of ancient Greek and Latin. As the rationale for the Project states on the site: "There may be considerable debate among scholars about the most 'authentic' way to pronounce Greek or Latin; yet it is certain that the texts from the ancient world reflect a vivid and complex spoken language, not a lifeless code." With that in mind, the site features different classical scholars reading passages by a number of writers, including Homer, Plato, Virgil, Horace, Ovid, and Seneca. As the scholars read, students can follow along, view the passage in English, and pause the recording in order to develop an understanding of the text and its pronunciation. Finally, the site also includes a brief essay on rhythm and meter in Greek and Latin.

334

Classically isospinning Skyrmion solutions  

NASA Astrophysics Data System (ADS)

We investigate how isospin affects the geometrical shape and energy of classical soliton solutions of topological charges B =1 - 4 ,8 in the Skyrme model. The novel approach in our work is that we study classically isospinning Skyrmions beyond the rigid-body approximation; that is, we explicitly allow the soliton solutions to deform and to break the symmetries of the static configurations. Our fully three-dimensional relaxation calculations reveal that the symmetries of isospinning Skyrme solitons can differ significantly from the ones of the static configurations. In particular, isospinning Skyrmion solutions can break up into lower-charge Skyrmions, can deform into new solution types that do not exist at vanishing angular frequency ? or energy degeneracy can be removed. These types of deformations have been largely ignored in previous work on modeling nuclei by quantized Skyrmion solutions.

Battye, Richard A.; Haberichter, Mareike; Krusch, Steffen

2014-12-01

335

Nucleosynthesis in classical novae  

E-print Network

A general review of the relevance of classical novae for the chemical evolution of the Galaxy, as well as for Galactic radioactivity is presented. A special emphasis is put on the pioneering work done by Jim Truran in this field of research. The impact of recent developments in nuclear astrophysics on nova nucleosynthesis, together with the prospects for observability of novae radioactivities with the INTEGRAL satellite are discussed.

M. Hernanz; J. Jose; A. Coc

2001-01-19

336

Classical pathway evaluation.  

PubMed

This unit describes several assay methods that can be used to determine the functional status of the classical pathway of complement and to quantitate its component proteins. The classical pathway includes C1qrs, C2, C4, C3, C5, C6, C7, C8, and C9, listed in the order in which they interact. Two CH(50) assay procedures are presented that test total classical pathway function; one is carried out in test tubes, whereas the alternate protocol describes a variation that is carried out in 96-well microtiter plates. Three support protocols describe preparing serum and erythrocyte-antibody complexes (EA) for use in CH(50) assays,and titrating of hemolysin for use in EA preparation. As an alternative to functional assays, radial immunodiffusion (RID) methods are also presented. These can be used to measure the concentrations of most circulating complement proteins and to evaluate the functional status of C1-esterase inhibitor. A fourth support protocol provides a method to determine antibody concentrations for RID assays. PMID:18432714

Giclas, P C

2001-05-01

337

Poor correlation between clonal immunoglobulin gene rearrangement and immunoglobulin gene transcription in Hodgkin's disease.  

PubMed Central

It recently has been suggested that some cases of Hodgkin's disease (HD) are derived from B lymphocytes. We therefore examined immunoglobulin heavy chain gene rearrangement and transcription by polymerase chain reaction in 30 cases of HD and compared them with 25 cases of non-Hodgkin's B-cell lymphoma. Clonal VDJ gene rearrangements were observed in 6 cases of HD. Of these 6 cases, clonal VDJ gene transcription was found by RNA-dependent polymerase chain reaction in only 2 cases. One of these 2 cases histologically showed composite lymphoma of HD and diffuse large B cell lymphoma. We performed in situ hybridization with a clonal VDJ gene probe in this case to determine the localization of the genetic clonality. The large lymphoma cells reacted positively, but Hodgkin's and Reed-Sternberg cells showed only nonspecific staining. No discrepancy between immunoglobulin gene rearrangement and transcription was observed in 24 of the 25 cases of non-Hodgkin's B-cell lymphoma. The discordance between clonal gene rearrangement and transcription in HD contrasts sharply with the high correlation of those processes in non-Hodgkin's B-cell lymphoma. Images Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 Figure 6 PMID:8863682

Yatabe, Y.; Oka, K.; Asai, J.; Mori, N.

1996-01-01

338

Aberrant expression of the dendritic cell marker TNFAIP2 by the malignant cells of Hodgkin lymphoma and primary mediastinal large B cell lymphoma distinguishes these tumor types from morphologically and phenotypically similar lymphomas  

PubMed Central

TNFAIP2 is a protein upregulated in response to TNF signaling but its cellular expression and function in normal and neoplastic tissues remains largely unknown. Here we use standard immunohistochemical techniques to demonstrate that TNFAIP2 is normally expressed by follicular dendritic cells, interdigitating dendritic cells, and macrophages but not by lymphoid cells in secondary lymphoid tissues. Consistent with this expression pattern, we found strong TNFAIP2 staining of tumor cells in 4/4 cases (100%) of follicular dendritic cell sarcoma and in 3/3 cases (100%) of histiocytic sarcoma. Although TNFAIP2 is not expressed by the small and intermediate-size neoplastic B-cells comprising follicular lymphoma, small lymphocytic lymphoma, mantle cell lymphoma, or marginal zone lymphoma, we observed strong TNFAIP2 staining of the large, neoplastic cells, in 31/31 cases (100%) of classical Hodgkin lymphoma, 12/12 cases (100%) of nodular lymphocyte predominant Hodgkin lymphoma, and 27/31 cases (87%) of primary mediastinal (thymic) large B cell lymphoma. In contrast, TNFAIP2 was expressed by the malignant cells in only 2/45 cases (4%) of diffuse large B cell lymphoma, not otherwise specified, 2/18 cases (11%) of Burkitt lymphoma, and 1/19 cases (5%) of anaplastic large cell lymphoma. Further analysis indicates that TNFAIP2, as a single diagnostic marker, is more sensitive (sensitivity= 87%) and specific (specificity= 96%) than TRAF1, nuclear cRel, or CD23 for distinguishing the malignant B-cells of primary mediastinal (thymic) large B cell lymphoma from those of its morphologic and immunophenotypic mimic, diffuse large B cell lymphoma, not otherwise specified. Thus, TNFAIP2 may serve as a useful new marker of dendritic and histiocytic sarcomas whose aberrant expression in the malignant cells of classical Hodgkin lymphoma and primary mediastinal (thymic) large B cell lymphoma serves to distinguish these tumors from other large cell lymphomas in routine clinical practice. PMID:21921781

Kondratiev, Svetlana; Duraisamy, Sekhar; Unitt, Christine L.; Green, Michael R.; Pinkus, Geraldine; Shipp, Margaret A.; Kutok, Jeffery L.; Drapkin, Ronny I.; Rodig, Scott J.

2011-01-01

339

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs  

PubMed Central

The classical Hodgkin-Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied by the resistance of the ion channels, and by the gating time constants. We study slow dynamics in an extended HH framework that includes time-dependent ion concentrations, pumps, and buffers. Fluxes across the neuronal membrane change intra- and extracellular ion concentrations, whereby the latter can also change through contact to reservoirs in the surroundings. Ion gain and loss of the system is identified as a bifurcation parameter whose essential importance was not realized in earlier studies. Our systematic study of the bifurcation structure and thus the phase space structure helps to understand activation and inhibition of a new excitability in ion homeostasis which emerges in such extended models. Also modulatory mechanisms that regulate the spiking rate can be explained by bifurcations. The dynamics on three distinct slow times scales is determined by the cell volume-to-surface-area ratio and the membrane permeability (seconds), the buffer time constants (tens of seconds), and the slower backward buffering (minutes to hours). The modulatory dynamics and the newly emerging excitable dynamics corresponds to pathological conditions observed in epileptiform burst activity, and spreading depression in migraine aura and stroke, respectively. PMID:25474648

Hübel, Niklas; Dahlem, Markus A.

2014-01-01

340

Fine-needle aspiration cytology diagnosis of non-Hodgkins lymphoma in a resource-challenged environment.  

PubMed

To establish the role of fine-needle aspiration cytology (FNAC) as a diagnostic tool for non-Hodgkins lymphoma in a resource challenged environment. This study was conducted on patients with lymphadenopathy, attending various clinics over a period of 18 months. FNAC of the enlarged lymph nodes was performed and biopsy, special stains and immunohistochemical staining was done in selected cases. Out of the total 275 cases, 42 cases (16%) were primary lymphoproliferative disorders. Non-Hodgkin lymphoma comprised of 32 cases (76.2% of all lymphomas), Hodgkin lymphoma-10 cases and the rest were metastatic carcinoma. The diagnostic accuracy for non-Hodgkin Lymphoma was 93.3%, sensitivity 95.4%, and specificity 87.5%. FNAC is a rapid, safe, easy, and nonexpensive diagnostic technique which can be used for early diagnosis of non-Hodgkins lymphoma. PMID:20857396

Alam, Kiran; Jain, Anshu; Maheshwari, Veena; Siddiqui, Farhan Asif; Haider, Nazima; Khan, Arshad Hafiz

2011-06-01

341

Writing Chinese and Mathematics Achievement: A Study with Chinese-American Undergraduates.  

ERIC Educational Resources Information Center

Indicates that writing Chinese is correlated to Chinese-American (CA) students' spatial skills and investigates whether writing Chinese would have the same relationship to mathematics skills. Suggested a strong correlation between writing Chinese and success on SAT-Math. Supports the cultural relativity theory of gender difference on SAT-Math.…

Li, Chieh; Nuttall, Ronald

2001-01-01

342

The ISI distribution of the stochastic Hodgkin-Huxley neuron.  

PubMed

The simulation of ion-channel noise has an important role in computational neuroscience. In recent years several approximate methods of carrying out this simulation have been published, based on stochastic differential equations, and all giving slightly different results. The obvious, and essential, question is: which method is the most accurate and which is most computationally efficient? Here we make a contribution to the answer. We compare interspike interval histograms from simulated data using four different approximate stochastic differential equation (SDE) models of the stochastic Hodgkin-Huxley neuron, as well as the exact Markov chain model simulated by the Gillespie algorithm. One of the recent SDE models is the same as the Kurtz approximation first published in 1978. All the models considered give similar ISI histograms over a wide range of deterministic and stochastic input. Three features of these histograms are an initial peak, followed by one or more bumps, and then an exponential tail. We explore how these features depend on deterministic input and on level of channel noise, and explain the results using the stochastic dynamics of the model. We conclude with a rough ranking of the four SDE models with respect to the similarity of their ISI histograms to the histogram of the exact Markov chain model. PMID:25339894

Rowat, Peter F; Greenwood, Priscilla E

2014-01-01

343

New immunohistochemistry for B-cell lymphoma and hodgkin lymphoma.  

PubMed

Context .- B-cell non-Hodgkin lymphoma is a heterogeneous group of lymphoproliferative malignancies with different clinical behaviors and treatments. It is important to differentiate individual B-cell lymphoma to apply the best treatment and management. Morphology and immunohistochemistry are the primary tools used for diagnosing lymphoma. There is a characteristic pattern of expression with immunohistochemical antibodies in most well-defined B-cell lymphomas. Some cases of B-cell lymphoma, however, show unusual morphologic and immunophenotypic features. The new and sometimes more specific antibodies have been developed recently, which may further define those lymphomas. Only with use of the antibodies over time does their true nature and specificity become evident. Objectives .- To present new antibodies for B-cell lymphoma that enhance the probability for diagnosis or can act as alternate markers in unusual cases, in which a B-cell lymphoma does not present with characteristic immunohistochemical staining, and to present prognostic markers that allow for better management of patients with specific B-cell lymphomas. Data Sources .- Data were obtained from literature review and figures from slides in personal practice. Conclusions .- The immunohistochemical antibodies presented in this article increase our ability to understand, diagnosis, and manage patients with B-cell lymphoma. PMID:25427044

Zhang, Xiaohong Mary; Aguilera, Nadine

2014-12-01

344

An evaluation of space-time clustering in Hodgkin's disease.  

PubMed

A survey in Greater Boston identified 1577 new cases of histologically-confirmed Hodgkin's disease (HD) diagnosed from 1959 to 1973. The spatial position of each case was taken as the place of residence at diagnosis, and the temporal position as the month and year of diagnosis. Sufficient data for analysis were available for 1398 cases (89%). Space-time clustering was evaluated by three different methods: (a) Knox, (b) David and Barton and (c) Ederer, Myers and Mantel. When all HD cases were considered, none of these methods revealed statistically significant clustering. When stratification by risk factors was done, each of the techniques found significant clustering for various subgroups. Young adult cases (age 16-45 yr) tended to cluster more than older cases (age 46-70) and Catholics more than Jewish or Protestant cases. Rather than suggesting clustering at the time of HD diagnosis, the sporadic and inconsistently positive findings of this study may reflect case aggregation at the time of shared etiologic exposures, particularly if HD has a long and/or variable latent period. PMID:6826690

Greenberg, R S; Grufferman, S; Cole, P

1983-01-01

345

Thyroid dysfunction after radiotherapy in children with Hodgkin's disease  

SciTech Connect

Thyroid function was measured in 119 children, 16 years of age or less, after radiotherapy (XRT) for Hodgkin's disease. Thyroid abnormalities developed in 4 of 24 children (17%) who received 2600 rad or less, and in 74 of 95 children (78%) who received greater than 2600 rad to the cervical area, including the thyroid. The abnormality in all but three (one with hyperthyroidism and two with thyroid nodules) included the development of elevated levels of thyroid stimulating hormone (TSH). Age, sex, and administration of chemotherapy were not significant factors in the development of thyroid dysfunction. All children had lymphangiograms (LAG) and no time relationship was noted between thyroid dysfunction and LAG-XRT interval. The mean interval from radiotherapy to documented thyroid dysfunction was 18 months in the low-dose group and 31 months in the high-dose group, with most patients becoming abnormal within 3 to 5 years. Of interest was a spontaneous return of TSH to within normal limits in 20 children and substantial improvement in another 7. This study confirms the occurrence of dose-related occult hypothyroidism in children following external irradiation of the neck.

Constine, L.S.; Donaldson, S.S.; McDougall, I.R.; Cox, R.S.; Link, M.P.; Kaplan, H.S.

1984-02-15

346

Blind Deconvolution of Hodgkin-Huxley neuronal model.  

PubMed

Neuron transforms information via a complex interaction between its previous states, its intrinsic properties, and the synaptic input it receives from other neurons. Inferring synaptic input of a neuron only from its membrane potential (output) that contains both sub-threshold and action potentials can effectively elucidate the information processing mechanism of a neuron. The term coined blind deconvolution of Hodgkin-Huxley (HH) neuronal model is defined, for the first time in this paper, to address the problem of reconstructing the hidden dynamics and synaptic input of a single neuron modeled by the HH model as well as estimating its intrinsic parameters only from single trace of noisy membrane potential. The blind deconvolution is accomplished via a recursive algorithm whose iterations contain running an extended Kalman filtering followed by the expectation maximization (EM) algorithm. The accuracy and robustness of the proposed algorithm have been demonstrated by our simulations. The capability of the proposed algorithm makes it particularly useful to understand the neural coding mechanism of a neuron. PMID:24110594

Lankarany, M; Zhu, W-P; Swamy, M N S; Toyoizumi, Taro

2013-01-01

347

Non-hodgkin's lymphomas in Saskatchewan: a clinicopathologic study.  

PubMed

In a retrospective clinical study of 208 previously untreated persons with non-Hodgkin's lymphomas the disorders were classified and staged according to the histopathologic criteria of Rappaport, Winter and Hicks and the Ann Arbor clinical staging classification.Nodular types constituted 22% and diffuse types 78% of the lymphomas. The nodular lymphomas were slightly more common in females and were clustered in the age range 30 to 90 years. The diffuse lymphomas were slightly more common in males; the age distribution was bimodal, with one peak in the age range 10 to 19 years and the other in the age range 60 to 69 years, but when the age distribution of the general population in which the lymphomas occurred was taken into account, the incidence of these lymphomas was found to be significantly higher (P < 0.001) in persons more than 69 years of age than in those 40 to 69 years of age.SURVIVAL CORRELATED WITH HISTOPATHOLOGIC TYPE: persons with nodular (follicular) lymphomas and diffuse lymphocytic well differentiated lymphomas had a significantly greater survival (P < 0.05) than those with other diffuse lymphomas. No significant difference in survival was noticed between persons with nodal and extranodal lymphomas.While Rappaport and colleagues' criteria are still very useful, it is important to recognize the nodular lymphoma as a specific entity requiring generally different management from diffuse lymphomas. Appreciation of the different biologic behaviour of the various lymphomas is important to clinicians planning therapy. PMID:356951

Cherian, T; Skinnider, L F; Wright, J L; Komjathy, G

1978-09-01

348

Organochlorines and risk of non-Hodgkin lymphoma.  

PubMed

Organochlorine chemicals and polychlorinated biphenyls (PCBs) have been suspected as possible risk factors for non-Hodgkin lymphoma (NHL). We investigated PCBs and organochlorine pesticides and risk of NHL in a population-based case-control study in British Columbia, Canada. Congeners of PCBs (including dioxinlike congeners) and pesticides or pesticide metabolites were measured in plasma of 422 pretreatment cases and 460 control subjects. This is so far the largest study to examine organochlorines in plasma to date. Several dioxin-like PCB congeners were associated with increased risk of NHL, including dioxin-like PCB nos. 118 and 156 with odds ratios (OR) for the highest versus lowest quartile between 1.6 and 1.8. Several non-dioxin-like congeners also showed significant associations. The PCB congener with the strongest association was no. 180 with an OR for the highest versus the lowest quartile of 1.83 (95% confidence interval = 1.18-2.84). Six pesticide analytes also showed a significant association with NHL; beta-hexachlorocyclohexane, p,p'-DDE, hexachlorobenzene, mirex, oxychlordane and trans-nonachlor. The strongest association was found for oxychlordane, a metabolite of the pesticide chlordane (highest vs. lowest quartile OR = 2.68, 95% confidence interval = 1.69-4.24). Our results provide further evidence that organochlorines contribute to NHL risk. PMID:17722095

Spinelli, John J; Ng, Carmen H; Weber, Jean-Philippe; Connors, Joseph M; Gascoyne, Randy D; Lai, Agnes S; Brooks-Wilson, Angela R; Le, Nhu D; Berry, Brian R; Gallagher, Richard P

2007-12-15

349

Advances in the Treatment of Relapsed or Refractory Hodgkin's Lymphoma  

PubMed Central

Hodgkin's lymphoma (HL) is diagnosed in 20,000 men and women annually in North America and Europe. Despite treatment advancements for HL resulting in an overall survival rate of 80%, patients with advanced stage disease continue to have suboptimal outcomes, with relapse rates of 30%–40%. An additional 10%–15% of patients present with primary refractory disease. For patients who relapse after initial treatment, salvage chemotherapy followed by autologous stem cell transplant in those with chemotherapy-sensitive disease is the standard of care. Patients who relapse after second-line therapy have a median survival time in the range of 6–36 months, and the optimal management of these patients remains unclear. Unfortunately, there have been no new agents approved for relapsed HL treatment since the 1970s. Consequently, clinical decision making in this population is difficult. Recently however, several agents have emerged that have shown clinical promise in this poor-risk population. This review discusses the management of these patients and also discusses several newer agents showing clinical promise in the treatment of HL. PMID:22387318

2012-01-01

350

Isolated III cranial nerve palsy: a Hodgkin's lymphoma?  

PubMed

A 69-year-old woman developed ptosis and diplopia due to an isolated pupil-involving left oculomotor nerve palsy. General examination was unremarkable. Initial workup showed a mild increase in cerebrospinal fluid proteins. Imaging studies were remarkable for a left oculomotor nerve enhancement in brain MRI and hyperfixation along the nerve's pathway in full body single-photon emission CT. Assuming the possible diagnosis of neurosarcoidosis, the patient was started on high-dose methylprednisolone. Three months later she developed pancytopenia. A bone marrow biopsy was performed and histopathology revealed infiltration by Hodgkin's lymphoma. Adriamycin, bleomycin, vinblastine, dacarbazine protocol chemotherapy was started and full haematological remission obtained after four cycles, despite mild oculomotor nerve palsy persisted. Isolated oculomotor palsy as the first presenting manifestation of a lymphoma is rare and alternative differential diagnosis must be considered in the absence of other lymphoma manifestations. In this case as with many rare initial manifestations of common diseases watchful waiting was crucial to the correct diagnosis and treatment strategy. PMID:24759607

Meireles, Joana; Garrett, Maria Carolina; Abreu, Pedro

2014-01-01

351

Increasing treatment options in indolent non-Hodgkin's lymphoma.  

PubMed

There is currently no standard first-line treatment for indolent non-Hodgkin's lymphoma (NHL) because there is no curative treatment. In asymptomatic patients, treatment with chemotherapy does not improve survival compared with a "watch and wait" approach. Improved treatment strategies, with curative intent, are thus required for indolent NHL. Rituximab is effective and well tolerated in the treatment of indolent NHL and can be considered for asymptomatic patients, where the side effects of chemotherapy may outweigh the benefits. In addition, rituximab does not compromise the use of subsequent chemotherapy in patients who relapse. A study of rituximab monotherapy in patients with low-tumor-burden follicular lymphoma has shown high rates of both clinical remission and molecular remission (clearance of bcl-2-positive cells from blood and/or bone marrow). After 2 years, half the patients relapsed, indicating that improved strategies are still required. Efforts to improve the efficacy of rituximab have included repeated administrations of the antibody and combined administration with chemotherapy or interferon-alpha2a. The optimal role of rituximab in first-line therapy for indolent NHL will be determined through randomized clinical trials. PMID:12040527

Solal-Céligny, Philippe

2002-04-01

352

[Hepatic involvement in patients with non-Hodgkins lymphoma].  

PubMed

Non-Hodgkins lymphoma (NHL) represent the most frequent hematological malignancy with frequent extranodal involvement. We have identified 79 pts (4.6%) out of 1,712 patients with NHL, who were diagnosed in our center between 1999-2010. Five cases were primary extranodal lymphomas and we have observed one primary hepatic lymphoma (0.015%). The most frequent (61.3%) NHL subtype in our cohort was diffuse large B-cell lymphoma. B-NHL formed 92.4% of all lymphomas. We have observed high number of HBsAg positive patients (10%). The whole group have poor prognostic features with high number of patients (85%) with intermediate-high and high risk according to international prognostic index. The patients were treated with chemotherapy in 95%, B-NHL patients recieved immunochemotherapy with rituximab in 77%. The median progression free survival, resp. overall survival 4.6, resp. 8.4 years in the whole group and 1.4, resp. 8.4 years in diffuse large B-cell lymphoma were observed with median follow-up 4.5 years. The outcome of T-NHL patients was significantly worse with overall survival median 1.2 vs 8.4 years (p < 0.033). The patients with B-NHL treated by immunochemoterapy with rituximab had significant death risk reduction (HR 0.44, p = 0.03) compared to the patients treated with chemotherapy. PMID:23909267

Trn?ný, M; Sálková, J; Dlouhá, J; St?íteský, J

2013-07-01

353

Morphometric characterisation of 52 B cell non-Hodgkin's lymphomas.  

PubMed Central

Fifty-two B cell non-Hodgkin's lymphomas, in which the diagnosis was based on immunological, cytochemical, and ultrastructural studies, were characterised by morphometry on plastic-embedded tissue sections. Parameters studied were: nuclear size, cytoplasmic area, cytoplasm to nucleus ratio, nuclear contour index, nucleolar size, location of nucleoli within the nucleus, as expressed by relative nucleolar eccentricity, and the mean number of nucleoli per nuclear cross-section. The results of the measurements and subsequent statistical analysis show that the different types of lymphoma can be distinguished from each other, even though the differences were small. Small cell lymphomas (chronic lymphocytic leukaemia, lymphoplasmacytoid and polymorphic immunocytoma, centrocytic, centroblastic/centrocytic and intermediate lymphocytic lymphomas) could be separated from each other by the standard error of mean (SEM) of nuclear area, the cytoplasm to nucleus ratio, and nuclear contour index. Large cell lymphomas (centroblastic and B immunoblastic lymphomas) could be differentiated with cytoplasm to nucleus ratio and nucleolar parameters (relative nucleolar eccentricity and number of nucleoli per nuclear cross-section). The morphometric parameters of lymphoblastic lymphomas fell in the range of the large cell lymphomas, but lower SEM indicate these lymphomas were more monomorphic. These morphometric data underline the concept of the Kiel classification and establish the usefulness of morphometry as an additional technique in diagnosis. PMID:6600749

van der Valk, P; Mosch, A; Kurver, P J; Meijer, C J

1983-01-01

354

Late effects of treatment for early-stage Hodgkin's disease.  

PubMed Central

A comprehensive survey of late effects (physical, social and reproductive) following treatment at a single institution for early stage Hodgkin's disease (HD) was performed. A total of 611 patients with stage I and II HD treated between 1973 and 1984 were reviewed; 460 were alive and were mailed a self-reported questionnaire. A total of 363 (79%) replies were received. Twenty patients died of second malignancy, 14 of heart disease and nine from respiratory disease. There were 37 cases of second malignancy [relative risk (RR) 2.2, absolute excess risk (AR) 35.8]. The 15-year incidence of heart disease was 11% and there were nine myocardial infarction deaths (RR 1.55, AR 5.4). Twenty-eight (8%) respondents stated that their career had been greatly interfered with, 53 (14.5%) perceived financial loss. Sexual activity was disrupted in 25.8%. In total, 56 men had fathered 112 pregnancies. Of 171 women, 40.3% became pregnant, resulting in 92 live births. A total of 43 men and 16 women had sought medical advice with regard to infertility. PMID:9579837

Brierley, J. D.; Rathmell, A. J.; Gospodarowicz, M. K.; Sutcliffe, S. B.; Munro, A.; Tsang, R.; Pintilie, M.

1998-01-01

355

Parametric Model of Combination Therapy for Non-Hodgkin Lymphoma  

PubMed Central

The development and clinical testing of drug combinations for the treatment of Non-Hodgkin Lymphoma (NHL) and other cancers has recently shown great promise. However, determining the optimum combination and its associated dosages for maximum efficacy and minimum side effects is still a challenge. This paper describes a parametric analysis of the dynamics of malignant B-cells and the effects of an anti-sense oligonucleotide targeted to BCL-2 (as-bcl-2), anti-CD-20 (rituximab) and their combination, for a SCID mouse human lymphoma xenograft model of NHL. Our parametric model is straightforward. Several mechanisms of malignant B-cell birth and death in the nodal micro-environment are simulated. Cell death is accelerated by hypoxia and starvation induced by tumor scale, by modification of anti-apoptosis with as-bcl-2, and by direct kill effects of rituximab (cell kill by cytotoxic immune cells is not included, due to the absence of an immune system in the corresponding experiments). We show that the cell population dynamics in the control animals are primarily determined by K*, the ratio of rate constants for malignant cell death, Kd, and cell birth, Kb. Tumor growth with independent treatments is reproduced by the model, and is used to predict their effect when administered in combination. Malignant cell lifetimes are derived to provide a quantitative comparison of the efficacy of these treatments. Future experimental and clinical applications of the model are discussed. PMID:23272153

Weiss, Robert F.; Miller, Merlin G.; Cronin, John F.; Hensley, Harvey H.; Joshi, Indira D.; Smith, Mitchell R.

2012-01-01

356

Pharmacogenetic analysis in the treatment of Hodgkin lymphoma.  

PubMed

About 15-20% of patients with Hodgkin lymphoma (HL) treated with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy ± radiotherapy still die following relapse or progressive disease. The outcome might be influenced by gene polymorphisms influencing chemotherapy metabolism. We studied 126 patients with HL treated with the ABVD regimen. We analyzed glutathione S-transferases (GSTT1, GSTM1 and GSTP1), cytochromes P450 (CYP3A4 and CYP2D6), UGT1A1 and BLMH gene polymorphisms and their association with clinical and outcome variables. Patients with a GSTM1 genotype associated with extensive or ultrahigh activity had a probability of 93.8% to achieve a complete response, while the remainder of the patients had a probability of 82.3% (p = 0.04). This variable maintained its statistical significance in multivariate analysis (hazard ratio 3.7, 95% confidence interval 1-13, p = 0.05). Patients with an extensive or ultrahigh GSTM1 genotype had better prognostic factors than those with poor or intermediate genotypes (hemoglobin level, p = 0.003; serum albumin, p = 0.05; and International Prognostic Score, p = 0.038). Thus, in the treatment of HL, clinical determinants might be more relevant than the pharmacogenetic parameters analyzed to date. PMID:23323945

Altés, Albert; Paré, Laia; Esquirol, Albert; Xicoy, Blanca; Rámila, Elena; Vicente, Laura; López, Rosario; Orriols, Jaume; Vall-llovera, Ferran; Sánchez-González, Blanca; del Río, Elisabeth; Sureda, Anna; Páez, David; Baiget, Montserrat

2013-08-01

357

Chinese herbal medicines for hypercholesterolemia  

PubMed Central

Background Hypercholesterolemia is an important key contributory factor for ischemic heart disease and is associated with age, high blood pressure, a family history of hypercholesterolemia, and diabetes. Chinese herbal medicines have been used for a long time as lipid-lowering agents. Objectives To assess the effects of Chinese herbal medicines on hypercholesterolemia. Search strategy We searched the following databases: The Cochrane Library (issue 8, 2010), MEDLINE (until July 2010), EMBASE (until July 2010), Chinese BioMedical Database (until July 2010), Traditional Chinese Medical Literature Analysis and Retrieval System (until July 2010), China National Knowledge Infrastructure (until July 2010), Chinese VIP Information (until July 2010), Chinese Academic Conference Papers Database and Chinese Dissertation Database (until July 2010), and Allied and Complementary Medicine Database (until July 2010). Selection criteria We considered randomized controlled clinical trials in hypercholesterolemic participants comparing Chinese herbal medicines with placebo, no treatment, and pharmacological or non-pharmacological interventions. Data collection and analysis Two review authors independently extracted data and assessed the risk of bias. We resolved any disagreements with this assessment through discussion and a decision was achieved based by consensus. We assessed trials for the risk of bias against key criteria: random sequence generation, allocation concealment, blinding of participants, incomplete outcome data, selective outcome reporting and other sources of bias. Main results We included 22 randomized trials (2130 participants). The mean treatment duration was 2.3 ± 1.3 months (ranging from one to six months). Twenty trials were conducted in China and 18 trials were published in Chinese. Overall, the risk of bias of included trials was high or unclear. Five different herbal medicines were evaluated in the included trials, which compared herbs with conventional medicine in six comparisons (20 trials), or placebo (two trials). There were no outcome data in any of the trials on cardiovascular events and death from any cause. One trial each reported well-being (no significant differences) and economic costs. No serious adverse events were observed. Xuezhikang was the most commonly used herbal formula investigated. A significant effect on total cholesterol (two trial, 254 participants) was shown in favor of Xuezhikang when compared with inositol nicotinate (mean difference (MD) ?0.90 mmol/L, 95% confidence interval (CI) ?1.13 to ?0.68) . Authors’ conclusions Some herbal medicines may have cholesterol-lowering effects. Our findings have to be interpreted with caution due to high or unclear risk of bias of the included trials. PMID:21735427

Liu, Zhao Lan; Liu, Jian Ping; Zhang, Anthony Lin; Wu, Qiong; Ruan, Yao; Lewith, George; Visconte, Denise

2011-01-01

358

Chinese immigrant entrepreneurs in New England area  

E-print Network

More and more Chinese immigrants came to the U.S. to start a whole new life. Some of them became entrepreneurs. This study focused on Chinese new immigrant entrepreneurs in New England area, and analyzed what factors have ...

Zhou, Joe Xiongwei

2008-01-01

359

Developing classification indices for Chinese pulse diagnosis  

E-print Network

Aim: To develop classification criteria for Chinese pulse diagnosis and to objectify the ancient diagnostic technique. Methods: Chinese pulse curves are treated as wave signals. Multidimensional variable analysis is performed to provide the best curve fit between the recorded Chinese pulse waveforms and the collective Gamma density functions. Results: Chinese pulses can be recognized quantitatively by the newly-developed four classification indices, that is, the wave length, the relative phase difference, the rate parameter, and the peak ratio. The new quantitative classification not only reduces the dependency of pulse diagnosis on Chinese physician's experience, but also is able to interpret pathological wrist-pulse waveforms more precisely. Conclusions: Traditionally, Chinese physicians use fingertips to feel the wrist-pulses of patients in order to determine their health conditions. The qualitative theory of the Chinese pulse diagnosis is based on the experience of Chinese physicians for thousands of year...

Shu, Jian-Jun

2014-01-01

360

Two computational approaches for creating Chinese painting  

E-print Network

In this thesis two computational approaches for creating Chinese painting are developed. The first approach uses an expressive paint tool that enables anyone to paint 2D Chinese paintings in real-time. The realistic rendering of paint strokes...

Chan, Ching

2012-06-07

361

Iconicity of simple Chinese characters.  

PubMed

The iconicity of a Chinese character, or the degree to which it looks like the concept that it represents, has been suggested as affecting the learning and processing of the character. However, previous studies have not provided good empirical information on the iconicity of specific characters. To fill this gap, 40 U.S. adults with no knowledge of Chinese were given an English word or short phrase together with two Chinese characters and were asked which character matched the meaning of the English word. The right and wrong answers had the same number of strokes, and different wrong answers were used for different participants. We examined all 213 simple-structure Chinese characters that occur in textbooks for elementary school children. The overall percentage of correct responses was 53.6%, slightly but significantly higher than would be expected by chance. Using a false discovery rate procedure, we found that 15 of the 213 characters were guessed at a level higher than chance. The proportion of correct responses to each character, which can be taken as an indicator of its degree of iconicity, should be useful to researchers studying Chinese character reading and writing. The full database, showing the proportion of correct guesses and other psycholinguistic variables for each character, can be downloaded from http://brm.psychonomic-journals.org/content/supplemental . PMID:22399244

Xiao, Wen; Treiman, Rebecca

2012-12-01

362

Quantum emulation of classical dynamics  

E-print Network

In statistical mechanics, it is well known that finite-state classical lattice models can be recast as quantum models, with distinct classical configurations identified with orthogonal basis states. This mapping makes classical statistical mechanics on a lattice a special case of quantum statistical mechanics, and classical combinatorial entropy a special case of quantum entropy. In a similar manner, finite-state classical dynamics can be recast as finite-energy quantum dynamics. This mapping translates continuous quantities, concepts and machinery of quantum mechanics into a simplified finite-state context in which they have a purely classical and combinatorial interpretation. For example, in this mapping quantum average energy becomes the classical update rate. Interpolation theory and communication theory help explain the truce achieved here between perfect classical determinism and quantum uncertainty, and between discrete and continuous dynamics.

Norman Margolus

2011-09-23

363

Late effects of radiation therapy in the treatment of Hodgkin's disease  

SciTech Connect

In the last two decades, a considerable amount of clinical and experimental animal data has been accumulated regarding the tolerance of the major normal tissues and organs traversed by the radiation beams in treating Hodgkin's disease. Typically, the tolerance of several tissues and organs must be considered in designing the very large radiation portals such as the mantle. Today, sophisticated machinery such as computerized tomography scanners, simulators, computers, and linear accelerators are available to improve the radiation planning and treatment of Hodgkin's disease. In this paper, researchers discuss the late effects of radiation therapy to the lung, heart, thyroid, kidney, gastrointestinal tract, and the gonads of adults with Hodgkin's disease. Emphasis is placed on our recommendations for modifications of radiation technique to improve the complication-free cure rate.

Kinsella, T.J.; Fraass, B.A.; Glatstein, E.

1982-04-01

364

Extranodal large B-cell type aggressive non-Hodgkin's lymphoma  

PubMed Central

Non-Hodgkin's lymphomas belong to a group of neoplasm originating from the cells of the lymphoreticular system that show diversity in their manner of presentation, response to therapy and prognosis. Non-Hodgkin's lymphoma accounts for 80–90% of all lymphomas. Although primary intraoral lesions in non-Hodgkin's lymphoma are uncommon, it is important to be aware of them as intraoral manifestations are a presenting symptom in these patients. A 72-year-old Indian male presented with a complaint of asymptomatic swelling in the left side of the face since 1.5 months. A careful clinical evaluation supported by radiologic, histopathologic and immunohistochemical investigations will help in identifying the disease at an early stage, which will result in better prognosis. PMID:25565759

Batra, Ranmeet; Kaur, Harshaminder; Jindal, Sachin

2014-01-01

365

Thoracic CT scanning for mediastinal Hodgkin's disease: results and therapeutic implications  

SciTech Connect

Thoracic CT scans were performed on 42 newly diagnosed patients with Hodgkin's disease. Five of 10 patients with negative chest X ray (CXR) had abnormal thoracic CT scans. Among the remaining 32 patients with mediastinal Hodgkin's disease (MHD) on CXR, pericardial (Ep) and chest wall invasion (Ec) were the two most common sites of involvement which were detectable by CT scan alone. Ep and Ec accounted for 16 of 19 of the changes in treatment portal or philosophy based on CT scan findings. Because of the high risk of cardiac or pulmonary radiation toxicity in Ep or Ec, radiation treatment alone may be inadequate. Treatment of mediastinal Hodgkin's disease is reviewed here. The use of CT scans for identification of Ep, Ec, and other abnormalities will allow for more precise treatment, further define the use of conventional radiotherapy, combined modality therapy or whole lung irradiation, and allow more accurate analysis of treatment results.

Rostock, R.A.; Siegelman, S.S.; Lenhard, R.E.; Wharam, M.D.; Order, S.E.

1983-10-01

366

Emerging non-transplant-based strategies in treating pediatric non-Hodgkin's lymphoma.  

PubMed

Lymphomas represent the third most common cancer in children and adolescents. The non-Hodgkin's lymphomas comprise a heterogeneous group of tumors, with distinct clinical and pathologic features. Although intensive multi-agent chemotherapy has made non-Hodgkin's lymphoma one of the most curable malignancies in children and young adults, there is room for improvement in treatment, particularly for those with advanced-stage disease and those who relapse after conventional therapy. New approaches are now attempting to reduce the burden of treatment, to focus on novel and more specific biologic targets, and to improve outcomes for patients with advanced-stage disease while reducing the potential for late effects. A comprehensive review of all potential agents is beyond the scope of this review, which will focus on some of the newer strategies for treating non-Hodgkin's lymphoma that are coming into clinical use today. PMID:20640605

Gore, Lia; Trippett, Tanya M

2010-10-01

367

Classic Slide Rule  

NSDL National Science Digital Library

In this activity, students construct classic slide rules and use them like calculators. Students use the slide rules to read scales, determine significant figures, and estimate decimal places.  This is activity D3 in the "Far Out Math" educator's guide. Lessons in the guide include activities in which students measure, compare quantities as orders of magnitude, become familiar with scientific notation, and develop an understanding of exponents and logarithms using examples from NASA's GLAST mission. These are skills needed to understand the very large and very small quantities characteristic of astronomical observations. Note: In 2008, GLAST was renamed Fermi, for the physicist Enrico Fermi.

368

Classical Trajectories and Quantum Spectra  

NASA Technical Reports Server (NTRS)

A classical model of the Schrodinger's wave packet is considered. The problem of finding the energy levels corresponds to a classical manipulation game. It leads to an approximate but non-perturbative method of finding the eigenvalues, exploring the bifurcations of classical trajectories. The role of squeezing turns out decisive in the generation of the discrete spectra.

Mielnik, Bogdan; Reyes, Marco A.

1996-01-01

369

Fano Interference in Classical Oscillators  

ERIC Educational Resources Information Center

We seek to illustrate Fano interference in a classical coupled oscillator by using classical analogues of the atom-laser interaction. We present an analogy between the dressed state picture of coherent atom-laser interaction and a classical coupled oscillator. The Autler-Townes splitting due to the atom-laser interaction is analogous to the…

Satpathy, S.; Roy, A.; Mohapatra, A.

2012-01-01

370

Dual Coding Theory and Chinese: Recall of Concrete and Abstract Sentences in Chinese-English Bilinguals  

E-print Network

DUAL CODING THEORY AND CHINESE: RECALL OF CONCRETE AND ABSTRACT SENTENCES IN CHINESE-ENGLISH BILINGUALS A Dissertation by TSUEI-FEN CHEN Submitted to the Office of Graduate Studies of Texas A&M University in partial... in Chinese-English Bilinguals Copyright August 2010 Tsuei-Fen Chen DUAL CODING THEORY AND CHINESE: RECALL OF CONCRETE AND ABSTRACT SENTENCES IN CHINESE-ENGLISH BILINGUALS A Dissertation by TSUEI-FEN CHEN Submitted to the Office...

Chen, Tsuei-Fen

2010-10-12

371

Fenretinide and Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Stage II Marginal Zone Lymphoma; Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia

2014-09-30

372

Understanding the high profitability of Chinese banks  

Microsoft Academic Search

The big Chinese state-owned banks came as winners out of the global financial crisis. According to the Banker ranking, Chinese banks led the global banking profitability ranking through the years from 2008 to 2010 and contributed one fifth of global banking profits in 2010. The Chinese banking sector, which was deemed as wholly insolvent ten years ago, was reborn like

Horst Löchel; Helena Xiang Li

2011-01-01

373

International Curriculum for Chinese Language Education  

ERIC Educational Resources Information Center

The International Curriculum for Chinese Language Education (ICCLE) represents a significant initiative by the Office of Chinese Language Council International (Hanban) to organise and describe objectives and content for a standardised Chinese language curriculum around the world. It aims to provide a reference curriculum for planning, a framework…

Scrimgeour, Andrew; Wilson, Philip

2009-01-01

374

Chinese Number Words, Culture, and Mathematics Learning  

ERIC Educational Resources Information Center

This review evaluates the role of language--specifically, the Chinese-based system of number words and the simplicity of Chinese mathematical terms--in explaining the relatively superior performance of Chinese and other East Asian students in cross-national studies of mathematics achievement. Relevant research is critically reviewed focusing on…

Ng, Sharon Sui Ngan; Rao, Nirmala

2010-01-01

375

Animals of the Chinese Zodiac. [Lesson Plan].  

ERIC Educational Resources Information Center

The Chinese lunar calendar dates back to the second millennium BC. Unlike the western calendar, which numbers the years progressively from the birth of Jesus Christ, the Chinese calendar is cyclical. Each cycle is made up of 12 years--after the 12th year, the cycle is repeated. The Chinese associate each year of a 12-year cycle with an animal, and…

2002

376

Factors Influencing the Learning of Chinese Characters  

ERIC Educational Resources Information Center

This survey study, which involved 108 language learners enrolled in first-year Chinese as a foreign language classrooms in the United States, intended to address the research questions, "What types of Chinese-character learning strategies do US learners use?" and "Do US learners' Chinese-character learning strategy use differ based on the…

Sung, Ko-Yin; Wu, Hsiao-Ping

2011-01-01

377

The Emerging Chinese economy & its Global Impacts  

E-print Network

in China: How it could affect the Chinese economy and the World Dr. Le-Yin Zhang, UCL 12 MarchThe Emerging Chinese economy & its Global Impacts Department of Geography & IDS University of Sussex 5 February: The Emerging Chinese Economy & its Global Impacts + Decoding the Harmonious Socialist

Sussex, University of

378

Saving Chinese-Language Education in Singapore  

ERIC Educational Resources Information Center

Three-quarters of Singapore's population consists of ethnic Chinese, and yet, learning Chinese (Mandarin) has been a headache for many Singapore students. Recently, many scholars have argued that the rhetoric of language planning for Mandarin Chinese should be shifted from emphasizing its cultural value to stressing its economic value since…

Lee, Cher Leng

2012-01-01

379

Subsyllabic Unit Preference in Young Chinese Children  

ERIC Educational Resources Information Center

We reported three experiments investigating subsyllabic unit preference in young Chinese children. In Experiment 1, a Chinese sound similarity judgment task was designed in which 48 pair of stimuli varied in terms of shared subsyllabic units (i.e., vowel, body, rime, onset-coda). Grade 1 Chinese-speaking monolingual children judged pairs with…

Wang, Min; Cheng, Chenxi

2008-01-01

380

Chinese-English Machine Translation System.  

ERIC Educational Resources Information Center

The report documents results of a two-year R&D effort directed at the completion of a prototype system for Chinese-English machine translation of S&T literature. The system, designated QUINCE, accepts Chinese input exactly as printed, with no pre-editing of any kind, and produces English output on experimental basis. Coding of Chinese text via…

Wang, William S-Y; And Others

381

BIBLIOGRAPHY AND GLOSSARY FOR CHINESE GRAMMAR.  

ERIC Educational Resources Information Center

THIS BIBLIOGRAPHY LISTS 937 TITLES IN THE FIELD OF CHINESE GRAMMAR FROM AMERICAN AND FOREIGN BOOKS, MAGAZINES, AND JOURNALS. THE AUTHORS AND TITLES ARE LISTED IN PINYIN SYSTEM TRANSCRIPTION WITH A TRANSLATION OF THE TITLE IN ENGLISH AND WITH CHINESE LOGOGRAPHS AFTER THE SOURCE CITATION FOR THOSE ENTRIES ORGINALLY WRITTEN IN CHINESE. ENTRIES ARE…

LIU, LILLIAN; WANG, W. S-Y

382

Flash Cards: Common Chinese-Cantonese Characters.  

ERIC Educational Resources Information Center

This set of flash cards is designed to accompany the Defense Language Institute's instructional programs in Cantonese Chinese. Each card displays six Chinese characters, for a total of 1500 characters. Each character is printed two inches tall. Above each character are transcriptions of the Chinese words represented by the character (marked for…

Defense Language Inst., Monterey, CA.

383

Symmetry in Chinese Arts Yip Lixia, Sabrina  

E-print Network

scales and the structure of the music itself. #12;5 Symmetry in Chinese Literature Symmetry has Cuttings · Symmetry in Chinese buildings · Chinese Music · Conclusion · Bibliography #12;3 Introduction influence in the arts is pervasive. In music, we hear the symmetry of exposition and recapitulation

Aslaksen, Helmer

384

Managerial Success Factors: A Chinese Profile  

ERIC Educational Resources Information Center

This article reports on an exploratory study conducted in the People's Republic of China (PRC) to identify the managerial success factors perceived by Chinese managers to be important in their market economy. The study also looked at how these factors are exhibited by recent graduates of Chinese universities now working in Chinese firms.…

Stivers, Bonnie P.; Adams, Janet S.; Liu, Bin

2007-01-01

385

Chinese Checker Versions of the Pythagorean Theorem  

Microsoft Academic Search

In this paper, we give Chinese checker versions of the Pythagorean Theorem, and show that the converses of these Chinese checker versions of the Pythagorean Theorem are not true. Finally, we give a necessary and sufficient condition for a triangle in the Chinese checker plane to have a right angle. Mathematics Subject Classification: 51K05, 51K99

Rustem Kaya

386

Methotrexate-induced Hodgkin disease in a patient with systemic lupus erythematosus.  

PubMed

Methotrexate sodium use in the management of various immunologic disorders has increased--as have the number of reported adverse effects associated with this therapy. While methotrexate has helped combat various autoimmune and cancerous disorders, the paradoxical risk of causing an often fatal malignancy may still occur as a result of the drug's effect on suppressing immune function. We present a case of methotrexate-induced Hodgkin disease in a 48-year-old man with a history of systemic lupus erythematosus (SLE). Discontinuation of methotrexate facilitated Hodgkin disease reversal. In addition, we review other lymphoproliferative hematologic malignancies caused by methotrexate. PMID:19556391

Sliesoraitis, Sarunas; Khan, Rizwan; Rothman, Jan

2009-06-01

387

Drug-antibody pair has promising activity in non-Hodgkin lymphoma  

Cancer.gov

A toxin linked to a targeted monoclonal antibody has shown "compelling" antitumor activity in patients with non-Hodgkin lymphomas who were no longer responding to treatment, according to a report from Dana-Farber Cancer Institute. The ongoing open-label phase 2 study presented at the American Society of Hematology (ASH) meeting was designed to test the activity of brentuximab vedotin (Adcetris) in relapsed or refractory non-Hodgkin lymphoma (NHL) including B-cell cancers such as diffuse large B cell lymphoma (DLBCL).

388

The Glory of Chinese Printing  

NSDL National Science Digital Library

This online exhibit from the Printing Museum of China examines the development, types, techniques, and artistry of Chinese printing with an emphasis on materials from ancient times. Different sections discuss the advent of standardized characters; character-carving skills; paper, writing brushes, and ink; the invention of printing; printing in the Mid- and Late-Tang, the Yuan, Ming, Song, Qing and Five dynasties; and more. Sections feature graphic elements with explanatory text (captions are provided in Chinese and English). The exhibit is supported by the Hong Kong Printers Association, the Graphic Arts Association of Hong Kong, and the Hong Kong Printing Industry Workers Union.

389

Perspective: Quantum or classical coherence?  

PubMed

Some coherence effects in chemical dynamics are described correctly by classical mechanics, while others only appear in a quantum treatment--and when these are observed experimentally it is not always immediately obvious whether their origin is classical or quantum. Semiclassical theory provides a systematic way of adding quantum coherence to classical molecular dynamics and thus provides a useful way to distinguish between classical and quantum coherence. Several examples are discussed which illustrate both cases. Particularly interesting is the situation with electronically non-adiabatic processes, where sometimes whether the coherence effects are classical or quantum depends on what specific aspects of the process are observed. PMID:22697519

Miller, William H

2012-06-01

390

Quantum models of classical systems  

E-print Network

Quantum statistical methods that are commonly used for the derivation of classical thermodynamic properties are extended to classical mechanical properties. The usual assumption that every real motion of a classical mechanical system is represented by a sharp trajectory is not testable and is replaced by a class of fuzzy models, the so-called maximum entropy (ME) packets. The fuzzier are the compared classical and quantum ME packets, the better seems to be the match between their dynamical trajectories. Classical and quantum models of a stiff rod will be constructed to illustrate the resulting unified quantum theory of thermodynamic and mechanical properties.

Petr Hajicek

2014-12-12

391

151Classics /Computer Science Classics 295 (3)--Topics in Classical Civilization  

E-print Network

151Classics /Computer Science Classics 295 (3)--Topics in Classical Civilization Selected subject-3)--Honors Thesis Prerequisite:Honorscandidacy. Fall-Winter CompuTeR SCIenCe (CSCI) PROFESSORS LAmBeRT, WHALEY ASSOCIATE PROFESSOR NECAISE ASSISTANT PROFESSOR LEVY MAJORS A major in computer science leading

Dresden, Gregory

392

The Chinese Brand: Soft Power with Chinese Characteristics  

Microsoft Academic Search

Following the Chinese Communist Party?s violent reaction to the 1989 Tiananmen Square protests, the People?s Republic of China experienced a diplomatic nightmare through international condemnation and economic sanctions. In the decades since the Tiananmen massacre, the CCP has focused on promoting itself as a ?responsible? power to the international community through a variety of soft power initiatives. Soft power, a

Nicholas Young

2011-01-01

393

Chinese Character Acquisition and Visual Skills in Two Chinese Scripts  

ERIC Educational Resources Information Center

Three different visual skills, along with Chinese character recognition, vocabulary, speeded naming, and syllable deletion skills were tested twice over one school year among 118 Hong Kong and 96 Xiangtan, China kindergartners. Results revealed that a task of Visual Spatial Relationships [Gardner, M. F. (1996). "Test of visual-perceptual skills…

Mcbride-Chang, Catherine; Chow, Bonnie W. Y.; Zhong, Yiping; Burgess, Stephen; Hayward, William G.

2005-01-01

394

Quantum Logic as Classical Logic  

E-print Network

We propose a semantic representation of the standard quantum logic QL within a classical, normal modal logic, and this via a lattice-embedding of orthomodular lattices into Boolean algebras with one modal operator. Thus our classical logic is a completion of the quantum logic QL. In other words, we refute Birkhoff and von Neumann's classic thesis that the logic (the formal character) of Quantum Mechanics would be non-classical as well as Putnam's thesis that quantum logic (of his kind) would be the correct logic for propositional inference in general. The propositional logic of Quantum Mechanics is modal but classical, and the correct logic for propositional inference need not have an extroverted quantum character. One normal necessity modality suffices to capture the subjectivity of observation in quantum experiments, and this thanks to its failure to distribute over classical disjunction. The key to our result is the translation of quantum negation as classical negation of observability.

Simon Kramer

2014-06-13

395

Was Pythagoras Chinese? An Examination of Right Triangle Theory in Ancient China. The Pennsylvania State University Studies No. 40.  

ERIC Educational Resources Information Center

This book is primarily a scholarly monograph on ancient Chinese theory and application concerning the right triangle, based on evidence contained in classical mathematics texts and scrolls. It is also the first complete English translation of the ninth chapter of the Chiu chang suan chu, the richest source of problems from antiquity dealing with…

Swetz, Frank J.; Kao, T. I.

396

Autologous stem cell transplantation in aggressive non-Hodgkin's lymphoma.  

PubMed

High dose therapy with autologous stem cell transplantation (ASCT) has been widely used in the past decade for treating aggressive non-Hodgkin's lymphoma in situations in which conventional therapy was not likely to cure patients. In patients achieving complete remission, ASCT has been proposed for consolidation in a group of lymphoma patients sharing adverse prognostic factors with a high risk of relapse. Results from pilot studies were encouraging. Analysis of the large randomized LNH87 trial, showed an increased survival and disease free survival advantage for ASCT performed after CR when compared to conventional chemotherapy if patients with 2 or more adverse factors were included. For patients who do not achieve CR after conventional treatment, but who are still sensitive to chemotherapy, ASCT may improve results. Pilot studies as well as randomized studies offer support for this approach. Intensive treatment with ASCT has been reported in thousands of relapsing lymphoma patients. For those remaining sensitive to salvage chemotherapy at 5 years, a 40% probability of disease free survival has been uniformly noted. Moreover, these results were confirmed by the randomized PARMA study testing ASCT vs conventional chemotherapy. ASCT is accepted by most centers as the treatment of choice for relapsing lymphoma. For lymphoblastic lymphoma and Burkitt's lymphoma, the role of ASCT in first CR is not well defined, although results from pilot studies and the analysis of registry data support the use of ASCT in lymphoblastic lymphoma with adverse prognostic factors. In conclusion, data supporting the use of ASCT in lymphoma in different settings has been provided by numerous non randomized trials. Completed randomized studies clearly demonstrate a benefit for ASCT in most relapsing patients as well as a subset of patients with poor prognosis. Socio-economic implications of such results must be evaluated, especially since the development of peripheral hematopoietic stem cells will reduce both toxicity and cost. PMID:8891721

Gisselbrecht, C

1996-08-01

397

Radioimmunotherapy of B-Cell Non-Hodgkin’s Lymphoma  

PubMed Central

This manuscript reviews current advances in the use of radioimmunotherapy (RIT) for the treatment of B-cell non-Hodgkin’s lymphoma (NHL). RIT has been in use for more than 20?years and has progressed significantly with the discovery of new molecular targets, the development of new stable chelates, the humanization of monoclonal antibodies (MAbs), and the use of pretargeting techniques. Today, two products targeting the CD20 antigen are approved: 131I-tositumomab (Bexxar®), and 90Y-ibritumomab tiuxetan (Zevalin®). 131I-tositumomab is available in the United States, and 90Y-ibritumumab tiuxetan in Europe, the United States, Asia, and Africa. RIT can be integrated in clinical practice using non-ablative activities for treatment of patients with relapsed or refractory follicular lymphoma (FL) or as consolidation after induction chemotherapy in front-line treatment in FL patients. Despite the lack of phase III studies to clearly define the efficacy of RIT in the management of B lymphoma in the era of rituximab-based therapy, RIT efficacy in NHL has been demonstrated. In relapsing refractory FL and transformed NHL, RIT as a monotherapy induces around 30% complete response with a possibility of durable remissions. RIT consolidation after induction therapy significantly improves the quality of the response. Dose-limiting toxicity of RIT is hematological, depending on bone marrow involvement and prior treatment. Non-hematological toxicity is generally low. Different studies have been published assessing innovative protocols of RIT or new indications, in particular treatment in patients with aggressive lymphomas. High-dose treatment, RIT as consolidation after different therapeutic induction modalities, RIT in first-line treatment or fractionated RIT showed promising results. New MAbs, in particular humanized MAbs, or combinations of naked and radiolabeled MAbs, also appear promising. Personalized dosimetry protocols should be developed to determine injected activity. PMID:23875170

Bodet-Milin, Caroline; Ferrer, Ludovic; Pallardy, Amandine; Eugène, Thomas; Rauscher, Aurore; Alain Faivre-Chauvet; Barbet, Jacques; Kraeber-Bodéré, Françoise

2013-01-01

398

Transcriptional deregulation of homeobox gene ZHX2 in Hodgkin lymphoma.  

PubMed

Recently, we identified a novel chromosomal rearrangement in Hodgkin lymphoma (HL), t(4;8)(q27;q24), which targets homeobox gene ZHX2 at the recurrent breakpoint 8q24. This aberration deletes the far upstream region of ZHX2 and results in silenced transcription pinpointing loss of activatory elements. Here, we have looked for potential binding sites within this deleted region to analyze the transcriptional deregulation of this tumor suppressor gene in B-cell malignancies. SiRNA-mediated knockdown and reporter gene analyses identified two transcription factors, homeodomain protein MSX1 and bZIP protein XBP1, directly regulating ZHX2 expression. Furthermore, MSX1-cofactor histone H1C mediated repression of ZHX2 and showed enhanced expression levels in cell line L-1236. As demonstrated by fluorescence in situ hybridization and genomic array analysis, the gene loci of MSX1 at 4p16 and H1C at 6p22 were rearranged in several HL cell lines, correlating with their altered expression activity. The expression of XBP1 was reduced in 6/7 HL cell lines as compared to primary hematopoietic cells. Taken together, our results demonstrate multiple mechanisms decreasing expression of tumor suppressor gene ZHX2 in HL cell lines: loss of enhancing binding sites, reduced expression of activators MSX1 and XBP1, and overexpression of MSX1-corepressor H1C. Moreover, chromosomal deregulations of genes involved in this regulative network highlight their role in development and malignancy of B-cells. PMID:22078940

Nagel, Stefan; Schneider, Björn; Meyer, Corinna; Kaufmann, Maren; Drexler, Hans G; Macleod, Roderick A F

2012-05-01

399

Serum YKL-40 and IL-6 Levels in Hodgkin Lymphoma  

PubMed Central

Purpose Serum levels of the inflammatory markers YKL-40 and IL-6 are increased in many conditions, including cancers. We examined serum YKL-40 and IL-6 levels in patients with Hodgkin lymphoma (HL), a tumor with strong immunologic reaction to relatively few tumor cells, especially in nodular sclerosis HL. Experimental Design We analyzed Danish and Swedish patients with incident HL (N=470) and population controls from Denmark (N= 245 for YKL-40; N= 348 for IL-6). Serum YKL-40 and IL-6 levels were determined by ELISA, and log-transformed data were analysed by linear regression, adjusting for age and sex. Results Serum levels of YKL-40 and IL-6 were increased in HL patients compared to controls (YKL-40: 3.6-fold, IL-6: 8.3-fold; both p<0.0001). In samples from pre-treatment HL patients (N=176), levels were correlated with more advanced stages (ptrend 0.0001 for YKL-40 and 0.013 for IL-6) and in those with B symptoms, but levels were similar in nodular sclerosis and mixed cellularity subtypes, by EBV status, and in younger (<45 years old) and older patients. Patients tested soon after treatment onset had significantly lower levels than pre-treatment patients, but even >6 months after treatment onset, serum YKL-40 and IL-6 levels remained significantly increased, compared to controls. In patients who died (N=12), pre-treatment levels for both YKL-40 and IL-6 were higher than in survivors, although not statistically significantly. Conclusions Serum YKL-40 and IL-6 levels were increased in untreated HL patients and those with more advanced stages but did not differ significantly by HL histology. Following treatment, serum levels were significantly lower. PMID:18980992

Biggar, Robert J.; Johansen, Julia S.; Smedby, Karin Ekström; Rostgaard, Klaus; Chang, Ellen T.; Adami, Hans-Olov; Glimelius, Bengt; Molin, Daniel; Hamilton-Dutoit, Stephen; Melbye, Mads; Hjalgrim, Henrik

2008-01-01

400

Epidemiological Overview of Hodgkin Lymphoma across the Mediterranean Basin  

PubMed Central

The epidemiology of Hodgkin lymphoma (HL) has always been a source of fascination to researchers due to its heterogeneous characteristics of presentation. HL is an uncommon neoplasm of B-cell origin with an incidence that varies significantly by age, sex, ethnicity, geographic location and socioeconomic status. This complex pattern was also found to be replicated among Mediterranean basin populations. HL incidence rates progressively decreased from industrialized European countries such as France (ASR=2.61) and Italy (ASR=2.39) to less developed nations such as Albania (ASR=1.34) and Bosnia Herzegovina (ASR=1.1). Regarding HL mortality we have found that countries with the lowest incidence rates show the highest number of deaths from this cancer and viceversa. Finally, a wide gap in terms of survival was showed across the Mediterranean basin with survival rates ranged from 82.3% and 85.1% among Italian men and women, to 53.3 % and 59.3% among Libyan men and women, respectively. Factors such as the degree of socio-economic development, the exposure to risk factors westernization-related, the availability of diagnostic practices along with different genetic susceptibilities to HL may explain its variation across Mediterranean countries. Furthermore, the lack of health resources decisively contribute to the poor prognosis recorded in less developed region. In the future, the introduction of appropriate and accessible treatment facilities along with an adequate number of clinical specialists in the treatment of HL and other cancers are warranted in order to improve the outcomes of affected patients and treat a largely curable type of cancer in disadvantaged regions. PMID:25045456

Salati, Massimiliano; Cesaretti, Marina; Macchia, Matteo; Mistiri, Mufid El; Federico, Massimo

2014-01-01

401

Phytanic acid and the risk of non-Hodgkin lymphoma  

PubMed Central

Greater consumption of red meat, processed meat and dairy products has been associated with an increased risk of non-Hodgkin lymphoma (NHL) in several previous reports. Phytanic acid, a saturated fatty acid obtained primarily through the consumption of ruminant meat and dairy products, may offer a potential underlying mechanism for these associations. In a population-based case–control study of 336 cases and 460 controls conducted in Nebraska during 1999–2002, we examined whether phytanic acid-containing foods or total phytanic acid intake, estimated from a food frequency questionnaire and the published phytanic acid values of 151 food items, were associated with increased NHL risk. Unconditional logistic regression was used to calculate odds ratios (ORs) and 95% confidence intervals for overall NHL and the common NHL histologic subtypes. In multivariable models, higher intakes of density-adjusted beef [ORT3 vs. T1 = 1.5 (1.1–2.2); Ptrend = 0.02], total dairy products [OR = 1.5 (1.1–2.2); Ptrend = 0.02) and milk [OR = 1.6 (1.1–2.3); Ptrend = 0.01] were associated with an increased risk of NHL. Intake of total phytanic acid was positively associated with NHL risk [OR = 1.5 (1.0–2.1); Ptrend = 0.04]. In analyses stratified by NHL subtype, greater consumption of beef was associated with an increased risk of diffuse large B-cell lymphoma, and greater consumption of milk was associated with an increased risk of follicular lymphoma (FL). Total phytanic acid intake was associated with an increased risk of FL and small lymphocytic lymphoma/chronic lymphocytic leukemia. Our results provide support that total phytanic acid and phytanic acid-containing foods may increase NHL risk. PMID:23042099

Ollberding, Nicholas J.

2013-01-01

402

Rituximab: an innovative therapy for non-Hodgkin's lymphoma.  

PubMed

The epidemiology, etiology, classification, and treatment of non-Hodgkin's lymphoma (NHL) are reviewed, and rituximab, a newly available therapy, is discussed. NHL comprises a group of lymphoproliferative disorders the frequency of which continues to rise. Although many classification systems exist for identifying specific histological subtypes, NHL is generally divided into indolent (low-grade) and aggressive (intermediate- and high-grade) forms. Low-grade NHL is characterized by a slowly progressive, continually relapsing course, with eventual transformation to a more rapidly progressive form that is usually fatal. Several options are available for the management of indolent NHL; none is curative. Rituximab, a human-mouse monoclonal antibody that targets the CD20 antigen expressed in over 90% of B-cell NHLs, provides an alternative to conventional chemotherapy that is relatively safe and effective. In a Phase III trial involving 166 patients with relapsed or refractory low-grade B-cell NHL, rituximab produced an overall response of 48%, with 20 of 80 responders still in remission more than 36 months after treatment. Study results in patients with bulky disease and those requiring retreatment have also been encouraging. Most adverse effects associated with rituximab are mild to moderate. Infusion-related reactions occur more commonly during initial infusions and in patients with evidence of increased tumor burden but can be effectively managed with premedication, supportive care, and adjusted infusion rates. Hematologic effects are generally mild and transient, and adverse immune responses are rare. Rituximab is an alternative to conventional chemotherapy for the treatment of relapsed or refractory low-grade or follicular CD20-positive B-cell NHL. PMID:11217177

Wood, A M

2001-02-01

403

Rituximab therapy for indolent non-Hodgkin's lymphoma.  

PubMed

Indolent non-Hodgkin's lymphomas (NHLs) are essentially incurable with current treatments. Rituximab is a specific anti-CD20 chimeric monoclonal antibody against the CD20 antigen, which is stably expressed on most B-cells (from the pre-B-cell stage). Compared with chemotherapy, rituximab has an excellent tolerability profile, making it a good therapeutic option for patients with indolent NHL. In the pivotal study for rituximab, patients with relapsed or refractory indolent or follicular lymphoma (FL) had an overall response rate of 50%. There is evidence that first-line rituximab therapy may be associated with better response rates; in previously untreated FL with a low tumor burden, rituximab monotherapy has produced an overall response rate of 73%. Attempts to improve response rates to rituximab by increasing the dose or frequency of dosing showed that the addition of four extra infusions of rituximab (in addition to the standard treatment schedule) resulted in an overall response rate of 76% in patients with FL. Augmenting rituximab with cytokines is also an option for increasing response rates in patients with indolent NHL. In a trial by the Nordic Lymphoma Study Group in patients with previously untreated or first-relapse indolent NHL, who had stable disease or a partial response after four doses of rituximab, 48% of the patients treated with rituximab plus interferon-alpha2a achieved a complete response. A further option is to combine rituximab with chemotherapy. Interim analyses from the East German Study Group have shown that rituximab plus mitoxantrone, chlorambucil and prednisolone (MCP) resulted in overall response rates of 89% in patients with untreated indolent lymphoma. Rituximab is therefore an excellent treatment option both as first-line and as salvage therapy for patients with indolent NHL. PMID:12710586

Hagenbeek, Anton; Czuczman, Myron S; Ghielmini, Michele; Herold, Michael; Kimby, Eva; Solal-Céligny, Philippe; Unterhalt, Michael

2002-11-01

404

ACR appropriateness criteria follow-up of Hodgkin lymphoma.  

PubMed

The main objectives of follow-up studies after completion of treatment for Hodgkin lymphoma are detection of recurrence for salvage therapy and monitoring for sequelae of treatment. The focus of the follow-up shifts, with time after treatment, from detection of recurrence to long-term sequelae. A majority of recurrence is detected by history and physical examination. The yield for routine imaging studies and blood tests is low. Although routine surveillance CT scan can detect recurrence not detected by history and physical examination, its benefit in ultimate survival and cost-effectiveness is not well defined. Although PET scan is a useful tool in assessing response to treatment, its routine use for follow-up is not recommended. Long-term sequelae of treatment include secondary malignancy, cardiovascular disease, pneumonitis, reproductive dysfunction, and hypothyroidism. Follow-up strategies for these sequelae need to be individualized, as their risks in general depend on the dose and volume of radiation to these organs, chemotherapy, age at treatment, and predisposing factors for each sequela. The ACR Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed every 3 years by a multidisciplinary expert panel. The guideline development and review include an extensive analysis of current medical literature from peer-reviewed journals and the application of a well-established consensus methodology (modified Delphi) to rate the appropriateness of imaging and treatment procedures by the panel. In those instances in which evidence is either lacking or not definitive, expert opinion may be used to recommend imaging or treatment. PMID:25278496

Ha, Chul S; Hodgson, David C; Advani, Ranjana; Dabaja, Bouthaina S; Dhakal, Sughosh; Flowers, Christopher R; Hoppe, Bradford S; Mendenhall, Nancy P; Metzger, Monika L; Plastaras, John P; Roberts, Kenneth B; Shapiro, Ronald; Smith, Sonali; Terezakis, Stephanie A; Winkfield, Karen M; Younes, Anas; Constine, Louis S

2014-11-01

405

Stomach Cancer Risk After Treatment for Hodgkin Lymphoma  

PubMed Central

Purpose Treatment-related stomach cancer is an important cause of morbidity and mortality among the growing number of Hodgkin lymphoma (HL) survivors, but risks associated with specific HL treatments are unclear. Patients and Methods We conducted an international case-control study of stomach cancer nested in a cohort of 19,882 HL survivors diagnosed from 1953 to 2003, including 89 cases and 190 matched controls. For each patient, we quantified cumulative doses of specific alkylating agents (AAs) and reconstructed radiation dose to the stomach tumor location. Results Stomach cancer risk increased with increasing radiation dose to the stomach (Ptrend < .001) and with increasing number of AA-containing chemotherapy cycles (Ptrend = .02). Patients who received both radiation to the stomach ? 25 Gy and high-dose procarbazine (? 5,600 mg/m2) had strikingly elevated stomach cancer risk (25 cases, two controls; odds ratio [OR], 77.5; 95% CI, 14.7 to 1452) compared with those who received radiation < 25 Gy and procarbazine < 5,600 mg/m2 (Pinteraction < .001). Risk was also elevated (OR, 2.8; 95% CI, 1.3 to 6.4) among patients who received radiation to the stomach ? 25 Gy but procarbazine < 5,600 mg/m2; however, no procarbazine-related risk was evident with radiation < 25 Gy. Treatment with dacarbazine also increased stomach cancer risk (12 cases, nine controls; OR, 8.8; 95% CI, 2.1 to 46.6), after adjustment for radiation and procarbazine doses. Conclusion Patients with HL who received subdiaphragmatic radiotherapy had dose-dependent increased risk of stomach cancer, with marked risks for patients who also received chemotherapy containing high-dose procarbazine. For current patients, risks and benefits of exposure to both procarbazine and subdiaphragmatic radiotherapy should be weighed carefully. For patients treated previously, GI symptoms should be evaluated promptly. PMID:23980092

Morton, Lindsay M.; Dores, Graça M.; Curtis, Rochelle E.; Lynch, Charles F.; Stovall, Marilyn; Hall, Per; Gilbert, Ethel S.; Hodgson, David C.; Storm, Hans H.; Johannesen, Tom Børge; Smith, Susan A.; Weathers, Rita E.; Andersson, Michael; Fossa, Sophie D.; Hauptmann, Michael; Holowaty, Eric J.; Joensuu, Heikki; Kaijser, Magnus; Kleinerman, Ruth A.; Langmark, Frøydis; Pukkala, Eero; Vaalavirta, Leila; van den Belt-Dusebout, Alexandra W.; Fraumeni, Joseph F.; Travis, Lois B.; Aleman, Berthe M.; van Leeuwen, Flora E.

2013-01-01

406

Access Excellence Classic Collection  

NSDL National Science Digital Library

Another good resource from AccessExcellence.org is the Activities Exchange Classic Collection Web site. The page presents links that focus on a single person or event by putting it into historical context and relating it to current science. Each contains a set of references, classroom activities, graphics, background information, and more. Some of the titles of the activities include The Discovery Of Radioactivity: The Dawn of the Nuclear Age; Radioactivity: Historical Figures; How We See: The First Steps of Human Vision; Discovery, Chance, and the Scientific Method; DNA Structure; and Development of Polio Vaccines. The pages and activities are well designed and offer educators some interesting and unique lessons for their students.

407

Classically isospinning Hopf solitons  

NASA Astrophysics Data System (ADS)

We perform full three-dimensional numerical relaxations of isospinning Hopf solitons with Hopf charge up to 8 in the Skyrme-Faddeev model with mass terms included. We explicitly allow the soliton solution to deform and to break the symmetries of the static configuration. It turns out that the model with its rich spectrum of soliton solutions, often of similar energy, allows for transmutations, formation of new solution types, and the rearrangement of the spectrum of minimal-energy solitons in a given topological sector when isospin is added. We observe that the shape of isospinning Hopf solitons can differ qualitatively from that of the static solution. In particular, the solution type of the lowest energy soliton can change. Our numerical results are of relevance for the quantization of the classical soliton solutions.

Battye, Richard A.; Haberichter, Mareike

2013-05-01

408

Classical and quantum ghosts  

NASA Astrophysics Data System (ADS)

The aim of these notes is to provide a self-contained review of why it is generically a problem when a solution of a theory possesses ghost fields among the perturbation modes. We define what a ghost field is and we show that its presence is associated with a classical instability whenever the ghost field interacts with standard fields. We then show that the instability is more severe at quantum level, and that perturbative ghosts can exist only in low energy effective theories. However, if we do not consider very ad hoc choices, compatibility with observational constraints implies that low energy effective ghosts can exist only at the price of giving up Lorentz invariance or locality above the cut-off, in which case the cut-off has to be much lower that the energy scales we currently probe in particle colliders. We also comment on the possible role of extra degrees of freedom which break Lorentz invariance spontaneously.

Sbisà, Fulvio

2015-01-01

409

Hodgkin and Reed-Sternberg cells in Hodgkin's disease represent the outgrowth of a dominant tumor clone derived from (crippled) germinal center B cells  

PubMed Central

In Hodgkin's disease (HD), the Hodgkin and Reed-Sternberg (HRS) cells represent only a minute population in the diseased tissue. The investigation of lineage derivation and clonal origin of these cells has yielded conflicting results. We have analyzed HRS cells micromanipulated from infiltrated tissue sections of 10 primary HD patients for rearranged V genes, extending a previous study. Clonally related rearrangements were found in nine cases, indicating that HRS cells represent a dominant clone of B lineage-derived cells in at least a large fraction of cases of HD. Rearranged VH genes from HRS cells carried a high load of somatic mutation, indicating that HRS cells are derived from germinal center (GC) cells or their progeny. Stop codons in some in-frame V gene rearrangements suggest that the HRS cell precursors reside inside GCs, have acquired crippling mutations that prevent antigenic selection, but escape apoptosis through some transforming event. PMID:8879220

1996-01-01

410

A Case of Primary Bone Marrow B-Cell Non Hodgkin’s Lymphoma with Severe Thrombocytopenia: Case Report and A Review of the Literature  

Microsoft Academic Search

A 78-year-old man presented with persistent gingival bleeding. He had low platelet count of 1.0 × 109\\/L without any lymphadenopathy. Bone marrow specimen showed diffusely distributed small-sized lymphocytes. Combined with immunophenotypic\\u000a analysis, a diagnosis of primary bone marrow B-cell non-Hodgkin’s lymphoma was made. Thrombocytopenia was considered to be\\u000a caused by autoimmune destruction of platelets.

Yuki Kagoya; Naohi Sahara; Takashi Matsunaga; Toshimasa Uekusa; Seiji Irie; Kazuhito Hatanaka

2010-01-01

411

Understanding Chinese-American Relations.  

ERIC Educational Resources Information Center

This three-part unit on the history of Chinese-American relations is intended for use with secondary students. Each of the three segments of the program requires about one hour of teaching time. Objectives of the unit are to help students: (1) become aware of the problems of cultural barriers and cultural stereotypes as illustrated through the…

Wilkinson, Mark

412

The Revolution in Chinese Education  

ERIC Educational Resources Information Center

Evaluates the extent to which the "revolution in education" in China has succeeded in integrating communist theory with practice. Concludes that the pre-1975 emphasis on political indoctrination has been tempered by efforts to raise the cultural and technical levels of the Chinese people. (Author/DB)

Seifman, Eli

1978-01-01

413

Progress in traditional Chinese medicine  

Microsoft Academic Search

Recently, traditional Chinese medicine (TCM) natural products have been used to produce impressive responses in atopic eczema and related dermatological disorders that have proved resistant to orthodox treatments. The increasing popularity of TCM natural products has also produced fear about their toxicity and uncertainty about their ingredients. In the western world, very little is known of the efficacy and safety

K. Chan

1995-01-01

414

Superoxide and traditional Chinese medicines  

Microsoft Academic Search

In traditional Chinese medicinal practices, herbs are classified as ‘cold’, ‘neutral’, or ‘hot’. Fluorometric analysis of herbs with ‘cold’ properties revealed that these herbs produce large amounts of superoxide. In contrast, herbs with ‘hot’ properties have scavenging activities. We believe that this electron transfer to form superoxide and the scavenging of superoxide may elucidate the phenomena of the ‘yin’ (represented

W. S. Lin; W. C. L. Chan; C. S. Hew

1995-01-01

415

Chinese Children's Explanations for Illness  

ERIC Educational Resources Information Center

The study explored how Chinese children spontaneously explained the causes of illness. Two groups of 3-, 4-, and 5-year-old children from different socioeconomic status (SES) backgrounds were recruited, with 30 children in each age group. A group of 30 college students were also recruited and their responses compared to those produced by the…

Zhu, Liqi; Liu, Guangyi; Tardif, Twila

2009-01-01

416

Eye Movements during Chinese Reading  

ERIC Educational Resources Information Center

respects, and for this reason, interest in the nature of the cognitive processes underlying Chinese reading has flourished over recent years. A number of researchers have used eye movement methodology as a measure of on-line processing to understand more about…

Liversedge, Simon P; Hyona, Jukka; Rayner, Keith

2013-01-01

417

Play Chinese Games. 1987, Revised.  

ERIC Educational Resources Information Center

This document, designed to introduce all ages to a selection of popular Chinese games, describes these games and provides instructions and materials for making the items needed to play most of them. Section 1 suggests class activities that can be related to some of the games. Section 2 presents instructions for the physical or outdoor games of:…

White, Caryn

418

Quantifying Affinity among Chinese Dialects.  

ERIC Educational Resources Information Center

A study of the relationships between Chinese dialects based on a quantitative measure of dialect affinity is summarized. First, tone values in all the dialect localities available in the early 1970s were used to calculate the dialectal differences in terms of tone height with respect to the "yin and yang" split. In the late 1970s, calculations of…

Cheng, Chin-Chuan

419

Bertrand Russell on Chinese Education  

ERIC Educational Resources Information Center

The visit of Bertrand Russell to China during 1920 to 1921 was one of the most significant events in May Fourth Movement, and Russell pointed out that education was the most important thing for Chinese reconstruction. The author argues that we should interpret Russell's educational idea of China from a theoretic and practical point of view. The…

Zheng, Wei-ping

2008-01-01

420

Residential and occupational exposure to sunlight and mortality from non-Hodgkin's lymphoma: composite (threefold) case-control study.  

PubMed Central

OBJECTIVE: To determine whether non-Hodgkin's lymphoma mortality is associated with sunlight exposure. DESIGN: Three case-control studies based on death certificates of non-Hodgkin's lymphoma, melanoma, and skin cancer mortality examining associations with potential sunlight exposure from residence and occupation. SETTING: 24 states in the United States. SUBJECTS: All cases were deaths from non-Hodgkin's lymphoma, melanoma, and non-melanotic skin cancer between 1984 and 1991. Two age, sex, and race frequency matched controls per case were selected from non-cancer deaths. MAIN OUTCOME MEASURES: Odds ratios for non-Hodgkin's lymphoma, melanoma, and skin cancer from residential and occupational sunlight exposure adjusted for age, sex, race, socioeconomic status, and farming occupation. RESULTS: Non-Hodgkin's lymphoma mortality was not positively associated with sunlight exposure based on residence. Both melanoma and skin cancer were positively associated with residential sunlight exposure. Adjusted odds ratios for residing in states with the highest sunlight exposure were 0.83 (95% confidence interval 0.81 to 0.86) for non-Hodgkin's lymphoma, 1.12 (1.06 to 1.19) for melanoma, and 1.30 (1.18 to 1.43) for skin cancer. In addition, non-Hodgkin's lymphoma mortality was not positively associated with occupational sunlight exposure (odds ratio 0.88; 0.81 to 0.96). Skin cancer was slightly positively associated with occupational sunlight exposure (1.14; 0.96 to 1.36). CONCLUSIONS: Unlike skin cancer and to some extent melanoma, non-Hodgkin's lymphoma mortality was not positively associated with exposure to sunlight. The findings do not therefore support the hypothesis that sunlight exposure contributes to the rising rates of non-Hodgkin's lymphoma. PMID:9167561

Freedman, D. M.; Zahm, S. H.; Dosemeci, M.

1997-01-01

421

Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

2014-08-26

422

Iodine I 131 Monoclonal Antibody BC8 Before Autologous Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; B-cell Chronic Lymphocytic Leukemia; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

2015-02-02

423

Adding Radiation to Chemotherapy May Improve Outcomes in Early-Stage Hodgkin Lymphoma  

Cancer.gov

Adding radiation therapy to chemotherapy may improve outcomes in patients with early-stage Hodgkin lymphoma, according to a paper published in the Cochrane Database of Systematic Reviews in February 2011, but the long-term effects of this regimen are not known.

424

Primary non Hodgkin's lymphoma of talus in a child-a rare presentation.  

PubMed

We report a rare case of primary non-Hodgkin's lymphoma of bone which presented with an osteolytic lesion of the head of the right talus which to the best of our knowledge is the first case to be reported in the paediatric age group. Early and accurate identification is necessary as it has a good prognosis. PMID:25277950

Patel, Sandeep; Sudesh, Pebam; John, Rakesh; Gupta, Parikshaa

2014-12-01

425

Diagnostic and therapeutic quandaries in primary manifestation of Hodgkin's disease in the central nervous system  

Microsoft Academic Search

. We report the case of a 23-year-old female with severe neurologic dysfunction without a clear cause at the time of initial presentation. The search for an underlying malignancy revealed a slightly enlarged cervical lymph node with Hodgkin's disease (HD). There was no evidence of a brain tumor despite nonspecific bright changes in proton density in the basal ganglia of

E. Kalinka; T. Robak; A. Wrzesien-Kus; E. Krykowski; K. Warzocha

2002-01-01

426

Central nervous system complications of non-Hodgkin's lymphoma. The potential role for prophylactic therapy  

Microsoft Academic Search

In 38 patients with non-Hodgkin's lymphoma, involvement of the central nervous system (CNS) by malignant lymphoma developed during an eight year period. All patients had lymphomatous meningitis; clinical involvement of the spinal nerves or cranial nerves suggested the diagnosis. Spinal fluid was abnormal in 97% of the patients although a positive cytology could be documented in only 67% by lumbar

Robert C. Young; Dianne M. Howser; Tom Anderson; Richard I. Fisher; Elaine Jaffe; Vincent T. DeVita Jr.

1979-01-01

427

Central nervous system involvement following diagnosis of non-Hodgkin's lymphoma: a risk model  

Microsoft Academic Search

Background: To determine the incidence and risk factors for central nervous system (CNS) relapse in patients with non-Hodgkin's lymphoma (NHL). Patients and methods: Patient records were registered prospectively in successive patients with NHL admitted to the Norwegian Radium Hospital from 1980 to 1996. A total of 2514 patients had no CNS involvement at diagnosis and were treated according to standard

A. Hollender; S. Kvaloy; O. Nome; E. Skovlund; K. Lote; H. Holte

2002-01-01

428

Kinetics of indium-III labelled lymphocytes in normal subjects and patients with Hodgkin's disease  

Microsoft Academic Search

The distribution in the body and the circulation in the blood of autologous lymphocytes labelled with indium-III were studied in two normal subjects and two patients with Hodgkin's disease. Four hours after injection radioactivity was identified in the spleen, liver, and bone marrow. Radioactivity, followed by imaging and whole body scanning, began to appear in the lymph nodes four to

J P Lavender; J M Goldman; R N Arnot; M L Thakur

1977-01-01

429

Heterogeneous malignant non Hodgkin's lymphomas as a causative disorder in lethal midline granuloma  

Microsoft Academic Search

The present report describes the results of a combined morphological, enzyme- and immunohistochemical analysis of nine cases of malignant non Hodgkin's lymphomas (NHL) clinically presenting as lethal midline granuloma. In a previous report written before antibodies directed against B and T lymphocytes were available, a histiocytic origin of such neoplasms had been suggested. A panel of antibodies reactive with most

R. Hubert Laeng; Heinz A. Gerber; Thomas Schaffner; Kurt H. Bürki

1989-01-01

430

Polymorphisms in Ghrelin and Neuropeptide Y Genes Are Associated with Non-Hodgkin Lymphoma  

E-print Network

in energy- regulating genes affect risk of NHL. (Cancer Epidemiol Biomarkers Prev 2005), and some cancers (3), including non- Hodgkin lymphoma (NHL). However, the mechanism under- lying with 19 different cancers, observed a 46% increased risk for NHL in people with a body mass index (BMI

California at Berkeley, University of

431

Body Mass Index, Leptin and Leptin Receptor Polymorphisms, and Non-Hodgkin Lymphoma  

E-print Network

of NHL in devel- oped countries. (Cancer Epidemiol Biomarkers Prev 2004;13(5):779­86) Introduction.S. and other industrialized countries, making NHL one of the most commonly diagnosed cancers in the Western ratios (ORs) for non-Hodgkin lymphoma (NHL), and the two major subtypes, diffuse large cell (DLCL

California at Berkeley, University of

432

Psychological distress after cancer cure: a survey of 459 Hodgkin's disease survivors  

Microsoft Academic Search

To assess the levels of psychological distress and identify predictors of anxiety\\/depression caseness after cancer cure, a national population of 557 Hodgkin's disease (HD) survivors was surveyed. The respondents [204 women, 255 men, mean age 44 years (SD = 12)] returned a mailed questionnaire including The Hospital Anxiety and Depression Scale (HADS). Disease and treatment variables were based on the

JH Loge; AF Abrahamsen; Ø Ekeberg; E Hannisdal; S Kaasa

1997-01-01

433

Aqueous Extract of Lavender Angustifolia Inhibits Lymphocytes Proliferation of Hodgkin's Lymphoma Patients  

PubMed Central

Background There are several types of cancer, which cause millions of deaths worldwide every year. Many studies have confirmed that plants are adequate natural sources to be examined as anti-cancer drugs with fewer side effects than chemotherapy and radiotherapy. In this study the anti-cancer properties of Lavender aqueous extract on lymphocytes derived from patients with Hodgkin's lymphoma has been studied. Methods In order to determine the cytotoxic effects of the extract on lymphocytes of patients in stages III and IV of Hodgkin's lymphoma and two different cell lines in the presence of different concentrations of aqueous extract of Lavender, MTT colorimetric assay and flow cytometry analysis were used. Results Findings indicated that Lavender inhibited cell proliferation in both lymphocytes and cell lines with different effects. The effective concentration of Lavender that decreased viability of Hodgkin's lymphoma cells below Lethal Concentration 50 (LC50) value was 100 µg/ml and this was half of the therapeutic dose. In addition, apoptosis was the main mechanism the Hodgkin's lymphoma cell encountered when exposed to the aqueous extract of Lavender. Conclusion This experiment proposes that aqueous Lavender extract can be regarded as a potential anti-cancer agent in future studies. PMID:25250135

Dalilan, Sona; Rezaei-Tavirani, Mostafa; Nabiuni, Mohammad; Heidari-Keshel, Saeed; Zamanian Azodi, Mona; Zali, Hakimeh

2013-01-01

434

Studying Mutations in Non-Hodgkin Lymphoma Yields Clues for Potential New Therapies  

Cancer.gov

DNA mutations found in a type of non-Hodgkin lymphoma that has a poor prognosis has led researchers at the National Cancer Institute (NCI), part of the National Institutes of Health, and their colleagues to a better understanding of how the cancer develops and how it might be treated.

435

Population-based survivorship research using cancer registries: a study of non-Hodgkin's Lymphoma survivors  

Cancer.gov

J Cancer Surviv (2007) 1:49–63 DOI 10.1007/s11764-007-0004-3 Population-based survivorship research using cancer registries: a study of non-Hodgkin’s Lymphoma survivors Neeraj K. Arora & Ann S. Hamilton & Arnold L. Potosky & Julia H. Rowland & Noreen

436

Risks and diagnosis of coronary artery disease in Hodgkin lymphoma survivors  

PubMed Central

Higher mortality rates are reported because of cardiovascular diseases in individuals living in industrialized areas of the World. In cancer patients, cardiotoxic chemotherapeutic agents and/or mediastinal radiotherapy are additional risk factors for the development of coronary artery disease. An improved survival rate for patients with Hodgkin lymphoma was reported in recent decades. Determining and handling the long-term effects of cancer treatment have become more important nowadays, parallel to the good results reached in survival rates. Mediastinal radiotherapy and cardiotoxic chemotherapeutic agents are routinely used to treat Hodgkin lymphoma but are commonly associated with a variety of cardiovascular complications. Drugs used in cancer treatment and radiotherapy may cause deleterious effects on contractile capacity and conduction system of the heart. Approximately ten years after the completion of all therapies, the cardiovascular disease risk peaks in patients who survived from Hodgkin lymphoma. The value of coronary computed tomography angiography as a diagnostic tool in determining coronary artery disease as early as possible is underlined in this review, in patients who are in remission and carry the risk of coronary artery disease probably because of chemo/radiotherapy used in their treatment. Survivors of Hodgkin lymphoma especially treated with combined chemoradiotherapy at younger ages are candidates for coronary computed tomography angiography. PMID:25068016

Kupeli, Serhan

2014-01-01

437

Post-Ganglionic Horner's Syndrome: An Unusual Presentation of Non-Hodgkin Lymphoma  

PubMed Central

In this paper, we present the rare case of a patient with cervical lymphadenopathy diagnosed as a T-cell-rich B-cell non-Hodgkin lymphoma that manifested Horner's syndrome due to a post-ganglionic sympathetic neuron lesion caused by the tumor. PMID:22611367

Ruiz e Resende, Lucilene Silva; Gaiolla, Rafael Dezen; Niéro-Melo, Lígia; Custódio Domingues, Maria Aparecida; de Lima Resende, Luiz Antônio

2012-01-01

438

Phenoxy herbicides and chlorophenols as risk factors for soft tissue sarcoma and non-Hodgkin's lymphoma  

SciTech Connect

A population-based case-control study evaluated the relationship between soft tissue sarcoma and non-Hodgkin's lymphoma and past exposure to phenoxy herbicides and chlorophenols in western Washington state. A major purpose of the study was to determine if the risk of cancer was elevated in relation to chemicals potentially contaminated with 2,3,7,8-tetra-chlorodibenzo-p-dioxin (TCDD). A total of 160 men with soft tissue sarcoma and 581 men with non-Hodgkin's lymphoma were group-matched with 694 randomly selected controls and were interviewed in person. Among the general population, no increased risks for either cancer were seen in relation to intensity or duration of past exposure to phenoxy herbicides or chlorophenols. Preliminary risk estimates for specific occupations that involve phenoxy herbicide or chlorophenol exposure included: farmer, herbicide formulator, applicator, forest sprayer, farmland sprayer, work in sprayed area, and work with or manufacture chlorophenyls. In addition, the risks of both soft tissue sarcoma and non-Hodgkin's lymphoma were elevated among men with past exposure to various insecticides, organic solvents and metals, and among those with preexisting compromise of the immune system. Multivariate studies are in progress to ascertain the contribution of diverse factors to the risks of soft tissue sarcoma or non-Hodgkin's lymphoma in association with phenoxy herbicides, chlorophenols, and/or TCDD.

Woods, J.; Polissar, L.; Severson, R.; Heuser, L.

1986-09-01

439

Kluver-Bucy syndrome in a boy with non-Hodgkin lymphoma.  

PubMed

Kluver-Bucy syndrome is a rare neurobehavioral condition characterized by visual agnosia, excessive oral tendency, hypermetamorphosis, placidity, altered sexual behaviors, and changes in dietary habits. The authors report a case of Kluver-Bucy syndrome in a 10-year-old boy with non-Hodgkin lymphoma after intratechal methotrexate administration. He was treated by risperidone without any sequels. PMID:17454782

Unal, Ekrem; Koksal, Yavuz; Baysal, Tamer; Energin, Me ltem; Aydin, Kursad; Caliskan, Umran

2007-03-01

440

Hodgkin's disease of the nasopharynx: diagnostic and therapeutic approach with a review of the literature  

Microsoft Academic Search

The lymphoid tissues of Waldeyer's ring, including the nasopharynx, are rarely involved in Hodgkin's disease (HD). Between March 1977 and July 2001, about 2150 patients affected by HD were observed in our institute; 7 of them (0.32%), all male patients, had HD of the nasopharynx. They had no symptoms and blood tests were normal. All patients were treated with chemotherapy

A. P. Anselmo; E. Cavalieri; L. Cardarelli; V. Gianfelici; F. M. Osti; E. Pescarmona; R. Maurizi Enrici

2002-01-01

441

Breast cancer occurred after treatment for Hodgkin's disease: analysis of 133 cases  

Microsoft Academic Search

Purpose: To assess the clinical and histological characteristics of breast cancer (BC) occurring after Hodgkin's disease (HD) and give possible therapies and prevention methods.Materials and methods: In a retrospective multicentric analysis, 117 women and two men treated for HD subsequently developed 133 BCs. The median age at diagnosis of HD was 24 years. The HD stages were stage I in

Bruno Cutuli; Christian Borel; Frédéric Dhermain; Stefano M Magrini; Todd H Wasserman; Jeffrey A Bogart; Mariano Provencio; Brigitte de Lafontan; Anne de la Rochefordiere; Enrico Cellai; Yvon Graic; Pierre Kerbrat; Claude Alzieu; Eric Teissier; Jean-Marie Dilhuydy; Hervé Mignotte; Michel Velten

2001-01-01

442

Gene Mutations Reveal Potential New Targets for Treating a Type of Non-Hodgkin's Lymphoma  

Cancer.gov

Researchers have discovered genetic mutations that may contribute to the development of an aggressive form of non-Hodgkin's lymphoma. These findings provide insight into a mechanism that cancer cells may use to survive, thus identifying potential new targets for treatment of the disease.

443

Reducing Treatment Intensity Doesn't Compromise Results in Early-Stage Hodgkin Lymphoma  

Cancer.gov

Reducing the dose of chemotherapy and radiotherapy did not compromise treatment efficacy in patients  with early-stage, low-risk Hodgkin lymphoma but led to fewer side effects, according to a study published August 12, 2010, in the New England Journal of Medicine.

444

The what and where of adding channel noise to the Hodgkin-Huxley equations  

Microsoft Academic Search

One of the most celebrated successes in computational biology is the Hodgkin-Huxley framework for modeling electrically active cells. This framework, expressed through a set of differential equations, synthesizes the impact of ionic currents on a cell's voltage -- and the highly nonlinear impact of that voltage back on the currents themselves -- into the rapid push and pull of the

Joshua H. Goldwyn; Eric Shea-Brown

2011-01-01

445

Sorafenib Tosylate in Treating Patients With Recurrent Aggressive Non-Hodgkin's Lymphoma  

ClinicalTrials.gov

Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma

2013-04-09

446

Harvard study finds body weight, diet may be risk factors for non-Hodgkin lymphoma:  

Cancer.gov

Body weight in young adulthood and diet appeared to be associated with the risk for non-Hodgkin lymphoma, according to results presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

447

Binding of phytohaemagglutinin to serum substances and inhibition of lymphocyte transformation in Hodgkin's disease.  

PubMed Central

Serum from eleven of fifty-four patients with Hodgkin's disease inhibited phytohaemagglutinin (PHA) stimulation of both autologous and homologous lymphocytes. The inhibitory effect resided in the macromolecular fraction of these sera. PHA was shown to bind to serum substances in inhibitory sera and the degree of PHA binding in the macromolecular fraction correlated directly with the extent of inhibition. PMID:1009684

Amlot, P L; Unger, A

1976-01-01

448

Biophysical Synaptic Dynamics in an Analog VLSI Network of Hodgkin-Huxley Neurons  

E-print Network

Biophysical Synaptic Dynamics in an Analog VLSI Network of Hodgkin-Huxley Neurons Theodore Yu1--We study synaptic dynamics in a biophysical net- work of four coupled spiking neurons implemented from a biophysical origin basis for the model implementation of the neurons and synapses coupled

Cauwenberghs, Gert

449

Late Effects May Not Warrant Using Radiation to Treat Early-Stage Hodgkin Lymphoma  

Cancer.gov

Patients with early-stage Hodgkin lymphoma who were treated with multidrug chemotherapy alone were more likely to be alive 12 years later than patients who received treatment that included radiation therapy, according to findings from a phase III clinical trial.

450

Residential proximity to industrial facilities and risk of non-Hodgkin lymphoma  

Microsoft Academic Search

Industrial pollution has been suspected as a cause of non-Hodgkin lymphoma (NHL), based on associations with chemical exposures in occupational studies. We conducted a case-control study of NHL in four SEER regions of the United States, in which residential locations of 864 cases and 684 controls during the 10 years before recruitment were used to characterize proximity to industrial facilities

A. J. De Roos; S. Davis; J. S. Colt; A. Blair; M. Airola; R. K. Severson; W. Cozen; J. R. Cerhan; P. Hartge; J. R. Nuckols; M. H. Ward

2010-01-01

451

Association of Killer Cell Immunoglobulin-Like Receptor Genes with Hodgkin's Lymphoma in a Familial Study  

Microsoft Academic Search

Background. Epstein-Barr virus (EBV) is the major environmental factor associated with Hodgkin's lymphoma (HL), a common lymphoma in young adults. Natural killer (NK) cells are key actors of the innate immune response against viruses. The regulation of NK cell function involves activating and inhibitory Killer cell Immunoglobulin-like receptors (KIRs), which are expressed in variable numbers on NK cells. Various viral

Caroline Besson; Sophie Roetynck; Fionnuala Williams; Laurent Orsi; Corinne Amiel; Catherine Lependeven; Guillemette Antoni; Olivier Hermine; Pauline Brice; Christophe Ferme; Patrice Carde; Danielle Canioni; Josette Brière; Martine Raphael; Jean-Claude Nicolas; Jacqueline Clavel; Derek Middleton; Eric Vivier; Laurent Abel

2007-01-01

452

Traditional Chinese medicine in treatment of opiate addiction  

Microsoft Academic Search

Traditional Chinese medicine (TCM) includes Chinese medicine and acupuncture. Chinese medicine consists of natural products including plants, animals and minerals. TCM has been practiced in China for more than 2000 years, and for the past 200 years has been used in treatment of drug addiction. Ten Chinese medicines for the treatment of opiate addiction have been approved by the Chinese

Jie Shi; Yan-li Liu; Yu-xia Fang; Guo-zhu Xu; Hai-fen Zhai; Lin Lu

2006-01-01

453

Indigenized conceptual and empirical analyses of selected Chinese psychological characteristics  

Microsoft Academic Search

An academic movement to switch from Westernized Chinese psychology to an indigenized Chinese psychology in Chinese societies (Taiwan, Hong Kong, and China) has existed for about three decades. Indigenous?oriented Chinese psychologists have conducted serious indigenized research on about 50 different broad topics. Kuo?Shu Yang's conceptual and empirical analyses on 3 of them are briefly reviewed in this article: (a) Chinese

2006-01-01

454

ClassicBookshelf.com  

NSDL National Science Digital Library

While there are any number of sites featuring public domain e-texts, this site stands out not so much for its content, but for its innovative Java reading applet. Visitors reading e-texts at this site do not have to settle for a sometimes difficult-to-read default display. Using the applet at the bottom of the viewing window, users can control the text size, font, and background color, picking a combination that makes reading easiest. The works featured at the site are listed by author name (best accessed via the site map link at the top right corner of the page), and include a number of classic works of (primarily) British and American literature, with an especially large collection of works by Charles Dickens. Entries for each author include several related sites (including webrings). From the site map page users can also perform keyword searches of the site's title and author listings, and access bookmarks, a helpful feature that allows readers to save their place in books between visits and return to where they left off.

455

Classical supersymmetric particles  

NASA Astrophysics Data System (ADS)

The dynamics of classical spinning particles is studied from the point of view of gauge supersymmetry. The central idea is that the natural way of introducing intrinsic spin degrees of freedom into a physical system is to take the square root of the Hamiltonian generators of the system without spin, which is equivalent to rendering the system gauge supersymmetric. This is accomplished by describing the spin degrees of freedom by means of ''anticommuting c-numbers'' (odd Grassman algebra elements) and relying on Dirac's theory of constrained Hamiltonian systems. The requirement of gauge supersymmetry fixes completely the action principle and leaves neither room nor need for ad hoc subsidiary conditions on the relative direction of the spin and the velocity as in the more traditional treatments. Both massive and massless particles free and in interaction with electromagnetic and gravitational fields are discussed. It is found that there exists a supergauge in which the spin tensor of a massive particle in a gravitational field is transported in parallel but the particle does not follow a geodesic. Massless particles on the other hand have the property of possessing a supergauge where their helicity is conserved and in which at the same time the worldline is a geodesic. Special attention is paid to the meaning and properties of the supergauge transformations. The main aspects of that discussion are applicable to more complicated systems such as supergravity. In particular phenomena such as necessity of invoking the equations of motion to close the gauge are analyzed.

Galvao, Carlos A. P.; Teitelboim, Claudio

1980-07-01

456

Classic clover cline clues.  

PubMed

Adaptive clines are striking examples of natural selection in action, yet few have been studied in depth. In this issue of Molecular Ecology, Kooyers & Olsen (2012) introduce modern analyses and thinking towards studies of a classical example of the rapid and repeated evolution of latitudinal and altitudinal clines in cyanogenesis in white clover, Trifolium repens L. Recognizing that adaptive clines represent trade-offs in the selective benefits of traits at different ends of a geographical transect, these researchers focus on whether evidence for selection can be found at regional (coarse) and local (fine) scales. After adjusting for population genetic patterns generated by demographic processes, Kooyers and Olsen provide evidence that the cyanogenesis cline is adaptive across a transect from Louisiana to Wisconsin, USA. Within local populations, divergent selection on coupling dominant and recessive alleles that underlie cyanogenesis is predicted to drive populations to gametic phase disequilibrium (LD), a pattern that has been found in several other studies reviewed by Kooyers and Olsen. The absence of LD within any sampled populations in this study leads the authors to suggest that selective patterns within these clines may be more complex than previously proposed, perhaps even following theoretical predictions of a geographic mosaic. PMID:22548253

Olson, Matthew S; Levsen, Nicholas

2012-05-01

457

Granzyme B expression in Reed-Sternberg cells of Hodgkin's disease.  

PubMed Central

Reed-Sternberg (RS) and Hodgkin's (H) cells are considered to be the neoplastic cells in Hodgkin's disease. Although most data suggest a lymphoid origin, the nature of these cells still remains the subject of considerable controversy. Recently, monoclonal antibodies became available, directed against granzyme B, a serine protease specifically expressed by activated cytotoxic T cells (CTLs) and natural killer (NK) cells. Using two granzyme B-specific antibodies directed against different epitopes, we studied the expression of granzyme B in a well characterized group of Epstein-Barr virus (EBV)-positive and EBV-negative cases of Hodgkin's disease. Granzyme B expression was found in part of the H-RS cells in 11 out of 61 tested cases (18%, 9 of 46 cases of nodular sclerosing and 1 of 12 mixed cellularity Hodgkin's disease). In none of these cases did H-RS cells express B-cell markers, whereas in four cases, expression of either the T-cell marker CD3 or CD8 was found in a small minority of H-RS cells. The percentage of granzyme B-positive H-RS cells ranged from < 10% to > 50%. Granzyme B-positive H-RS cells were present in 6 of 26 EBV-positive cases and in 5 of 35 EBV-negative cases, indicating no relationship with the presence of EBV. Moreover, no significant differences were found regarding either stage at presentation or clinical outcome. We conclude that in a restricted number of cases of Hodgkin's disease, the H-RS cells express granzyme B, and therefore might be considered the neoplastic equivalent of either activated CTLs or NK cells. Images Figure 1 Figure 2 PMID:8546210

Oudejans, J. J.; Kummer, J. A.; Jiwa, M.; van der Valk, P.; Ossenkoppele, G. J.; Kluin, P. M.; Kluin-Nelemans, J. C.; Meijer, C. J.

1996-01-01

458

Japanese Learning System for Chinese Native Speakers - Development of Database for Learning Kanji Which Have Difference between Chinese and Japanese  

Microsoft Academic Search

Although native speakers of Chinese have basic knowledge of Kanji (Chinese characters), learning Kanji is hard task to them. The difficulties of Kanji learning for Chinese speakers are different from those for non-Chinese character area learners. They are, for example, influenced by Chinese to their uses of Japanese, plural readings of each Kanji, and Kanji's different form (Ijitai in Japanese).

Sa Lu; Naoko Yamashita; Hiroyuki Tominaga; Toshihiro Hayashi; Toshinori Yamasaki

2005-01-01

459

Invitation by the Chinese (PhD) students to the M4M mentors "Chinese Spring Festival Party 2011"  

E-print Network

of the first lunar month of Chinese Calendar year, and is the most important festival for the Chinese peopleInvitation by the Chinese (PhD) students to the M4M mentors "Chinese Spring Festival Party 2011 and is when all family members get together, just like Christmas in the West. Each year, a Chinese New Year

Pfeifer, Holger

460

Treatment of relapsed CD20 Hodgkin lymphoma with the monoclonal antibody rituximab is effective and well tolerated: results of a phase 2 trial of the German Hodgkin Lymphoma Study Group  

Microsoft Academic Search

This phase 2 trial was performed to evalu- ate the safety and efficacy of the chimeric monoclonal anti-CD20 antibody ritux- imab in patients with relapsed lympho- cyte-predominant Hodgkin lymphoma or other CD20 subtypes of Hodgkin dis- ease (HD). Eligibility criteria required ex- pression of the CD20 antigen on more than 30% of malignant cells. Fourteen patients were treated with 4

Ute Rehwald; Holger Schulz; Marcel Reiser; Markus Sieber; Jan Oliver Staak; Franck Morschhauser; Christoph Driessen; Thomas Rudiger

461

An investigation on English/Chinese Code-switching in BBS in Chinese Alumni's Community.  

E-print Network

??The study, based on Myers-Scotton’s revised Markedness Model, investigates English/Chinese code-switching in BBS in Chinese alumni’s community, aiming to prove people are rational calculator when… (more)

Ge, Luqun

2007-01-01

462

A Classic Beauty  

NASA Technical Reports Server (NTRS)

M51, whose name comes from being the 51st entry in Charles Messier's catalog, is considered to be one of the classic examples of a spiral galaxy. At a distance of about 30 million light-years from Earth, it is also one of the brightest spirals in the night sky. A composite image of M51, also known as the Whirlpool Galaxy, shows the majesty of its structure in a dramatic new way through several of NASA's orbiting observatories. X-ray data from NASA's Chandra X-ray Observatory reveals point-like sources (purple) that are black holes and neutron stars in binary star systems. Chandra also detects a diffuse glow of hot gas that permeates the space between the stars. Optical data from the Hubble Space Telescope (green) and infrared emission from the Spitzer Space Telescope (red) both highlight long lanes in the spiral arms that consist of stars and gas laced with dust. A view of M51 with the Galaxy Evolution Explorer telescope shows hot, young stars that produce lots of ultraviolet energy (blue).

The textbook spiral structure is thought be the result of an interaction M51 is experiencing with its close galactic neighbor, NGC 5195, which is seen just above. Some simulations suggest M51's sharp spiral shape was partially caused when NGC 5195 passed through its main disk about 500 million years ago. This gravitational tug of war may also have triggered an increased level of star formation in M51. The companion galaxy's pull would be inducing extra starbirth by compressing gas, jump-starting the process by which stars form.

2007-01-01

463

Innovation: the classic traps.  

PubMed

Never a fad, but always in or out of fashion, innovation gets rediscovered as a growth enabler every half dozen years. Too often, though, grand declarations about innovation are followed by mediocre execution that produces anemic results, and innovation groups are quietly disbanded in cost-cutting drives. Each managerial generation embarks on the same enthusiastic quest for the next new thing. And each generation faces the same vexing challenges- most of which stem from the tensions between protecting existing revenue streams critical to current success and supporting new concepts that may be crucial to future success. In this article, Harvard Business School professor Rosabeth Moss Kanter reflects on the four major waves of innovation enthusiasm she's observed over the past 25 years. She describes the classic mistakes companies make in innovation strategy, process, structure, and skills assessment, illustrating her points with a plethora of real-world examples--including AT&T Worldnet, Timberland, and Ocean Spray. A typical strategic blunder is when managers set their hurdles too high or limit the scope of their innovation efforts. Quaker Oats, for instance, was so busy in the 1990s making minor tweaks to its product formulas that it missed larger opportunities in distribution. A common process mistake is when managers strangle innovation efforts with the same rigid planning, budgeting, and reviewing approaches they use in their existing businesses--thereby discouraging people from adapting as circumstances warrant. Companies must be careful how they structure fledgling entities alongside existing ones, Kanter says, to avoid a clash of cultures and agendas--which Arrow Electronics experienced in its attempts to create an online venture. Finally, companies commonly undervalue and underinvest in the human side of innovation--for instance, promoting individuals out of innovation teams long before their efforts can pay off. Kanter offers practical advice for avoiding these traps. PMID:17131564

Kanter, Rosabeth Moss

2006-11-01

464

Second malignancies in Hodgkin's disease: A review of the literature and report of a case with a secondary Lennert's lymphoma  

PubMed Central

A small percentage of patients treated for Hodgkin's disease are at risk of developing a second malignancy. The appearance of secondary malignancies such as leukemia, carcinoma or non-Hodgkin's lymphomas may be attributed to the mutagenic effects of chemotherapy and/or radiotherapy. Most secondary non-Hodgkin's lymphomas are of the B-cell type, but isolated cases were reportedly of a T-cell lineage. A review of the literature pertaining to the development of secondary peripheral T-cell lymphomas is presented along with the description of an additional case. The latter developed in the tonsil and was diagnosed as a Lennert's lymphoma (lymphoepithelioid T cell lymphoma)on histological and immunological grounds. This report also reviews the development of a of peripheral T-cell lymphoma described in patients following chemotherapy and/or radiotherapy for Hodgkin's disease PMID:25364188

Norval, Ernst JG; Raubenheimer, Erich J

2014-01-01

465

Wayne State researcher presents findings on drugs that lead to killing of non-Hodgkin's lymphoma tumors:  

Cancer.gov

A Wayne State University School of Medicine researcher believes he has found a safer, more effective way to keep cancer cells from protecting themselves against tumor-killing drugs in cases of non-Hodgkin’s lymphoma.

466

Radiotherapy for Early-Stage Hodgkin's Lymphoma: A 21st Century Perspective and Review of Multiple Randomized Clinical Trials  

SciTech Connect

The treatment of Hodgkin's lymphoma has improved dramatically over the past decades. Over the last half century, Hodgkin's lymphoma has become one of the most curable cancers of adulthood. More than 90% of the patients with localized stages of the disease can be cured with modern treatment strategies. Long-term toxicities are now the major concern for survivors of early-stage disease. Contemporary therapeutic approaches for Hodgkin's lymphoma attempt to preserve the high cure rate achieved, while reducing treatment-related acute and late toxicities. The aim of this review is to re-examine the historical and the current role of radiotherapy for early-stage Hodgkin's lymphoma, given the latest evidence of an increasing role of chemotherapy for the treatment of this malignancy. The literature search was performed in PubMed Plus. Studies on children were excluded.

Bar Ad, Voichita [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)], E-mail: barad@xrt.upenn.edu; Paltiel, Ora [Department of Hematology and School of Public Health, Hadassah-Hebrew University, Jerusalem (Israel); Glatstein, Eli [Department of Radiation Oncology, University of Pennsylvania, Philadelphia, PA (United States)

2008-12-01

467

Second malignancies in Hodgkin's disease: A review of the literature and report of a case with a secondary Lennert's lymphoma.  

PubMed

A small percentage of patients treated for Hodgkin's disease are at risk of developing a second malignancy. The appearance of secondary malignancies such as leukemia, carcinoma or non-Hodgkin's lymphomas may be attributed to the mutagenic effects of chemotherapy and/or radiotherapy. Most secondary non-Hodgkin's lymphomas are of the B-cell type, but isolated cases were reportedly of a T-cell lineage. A review of the literature pertaining to the development of secondary peripheral T-cell lymphomas is presented along with the description of an additional case. The latter developed in the tonsil and was diagnosed as a Lennert's lymphoma (lymphoepithelioid T cell lymphoma)on histological and immunological grounds. This report also reviews the development of a of peripheral T-cell lymphoma described in patients following chemotherapy and/or radiotherapy for Hodgkin's disease. PMID:25364188

Norval, Ernst Jg; Raubenheimer, Erich J

2014-09-01

468

Diffuse large B-cell non-Hodgkin lymphoma of the prostate presenting with urinary outlet obstruction: A case report  

PubMed Central

Large B-cell non-Hodgkin lymphoma involving the prostate accounts for 0.09% and 0.1% of non-Hodgkin lymphoma. We report a case of prostatic large B-cell non-Hodgkin lymphoma in a 77-year-old male with symptoms of urinary retention most probably due to benign prostate hyperplasia. He underwent multiple needle core biopsies through transrectal ultrasound of the prostate. Histopathological examination of the core biopsies revealed diffuse infiltration by atypical lymphoid cells in the prostatic stroma, which was strongly positive for leukocyte common antigen and CD20. CD3, CK, PSA, BCL2, k-light chain, Cyclin D1 and synaptophysin were negative. Histopathology and immunohistochemical profile in the case was consistent with the diagnosis of diffuse large B-cell non-Hodgkin lymphoma of the prostate. PMID:25657557

Rao, Ram Nawal; Bansal, Megha; Raghuvanshi, Shiwanjali; Ansari, M. S.; Neyaz, Zafar

2015-01-01

469

[Translation and dissemination of Chinese pulse lore in the west: with its English translation and dissemination as the focus].  

PubMed

Descriptive translation study approach from the perspective of polysystem theory developed by Holmes J., Even-Zohar I. and Toury G. investigates translation in its historical and cultural contexts, and thus offers a new method from a new perspective to study the history of translation of Chinese medicine. Over 300 years has passed by since the first work on Chinese pulse lore in a Western language came out in the 17th century. Many works of this topic in Western languages have got published since then. Descriptive translation study approach from the perspective of polysystem theory is applied to describe 9 representative works on Chinese pulse lore in Western languages in a comprehensive diachronic way, which takes its translation and dissemination in the West as the theme and its English translation as the focus. And the historical route and law of its translation and dissemination in the West have thus been presented: translation contents began with skills and then gradually involved classical texts; the trend is to give a comprehensive interpretation of Chinese medicine from its theoretical foundation to its clinical techniques from a cross-cultural perspective and based on classical Chinese medical texts and cultural differences between medicine East and West. PMID:24429034

Liang, Xing; Lan, Feng

2013-09-01

470

Classic African American Children's Literature  

ERIC Educational Resources Information Center

The purpose of this article is to assert that there are classic African American children's books and to identify a sampling of them. The author presents multiple definitions of the term classic based on the responses of children's literature experts and relevant scholarship. Next, the manner in which data were collected and analyzed in regard to…

McNair, Jonda C.

2010-01-01

471

Dynamical Symmetries in Classical Mechanics  

ERIC Educational Resources Information Center

We show how symmetries of a classical dynamical system can be described in terms of operators that act on the state space for the system. We illustrate our results by considering a number of possible symmetries that a classical dynamical system might have, and for each symmetry we give examples of dynamical systems that do and do not possess that…

Boozer, A. D.

2012-01-01

472

The classical case for monopoles  

SciTech Connect

A classical argument is given which suggests that free magnetic monopoles exist and, in fact, are quite common, and doubt is cast on Dirac's results on monopoles and especially on his formula for their magnetic charge. Also, a series of classical experiments aimed at their discovery is discussed.

Allen, D.P. Jr.

1991-04-01

473

A conversational Chinese Tutoring Machine  

E-print Network

of instructional interactions. The current releases of author languages include Coursewriter, PLANIT, PILOT, IDF [2]. Coursewriter is the earliest ezample of an author language. Originally, this lan- guage was used to computerize programmed instruction material... of an Artificially Intelligent Language Tutor". Currently, only a tutor which grades Chinese pron- unciations is implemented. CHAPTER II COURSEWARE DEVELOPMENT Currently two prototype lessons are implemented in the language tutoring courseware. Each lesson...

Cheng, Long-Fung

2012-06-07

474

Health Information in Chinese - Simplified (????): MedlinePlus  

MedlinePLUS

... ???? (Chinese - Simplified) PDF Environmental Protection Agency Head Lice Head Lice ?? - ???? (Chinese - Simplified) Bilingual PDF Health Information ... PDF Health Information Translations K Return to top Kidney Diseases IVP (Intravenous Pyelogram) IVP (??????) - ???? (Chinese - ...

475

75 FR 5767 - All Terrain Vehicle Chinese Language Webinar; Meeting  

Federal Register 2010, 2011, 2012, 2013

...COMMISSION All Terrain Vehicle Chinese Language Webinar; Meeting AGENCY: Consumer Product...meeting: All Terrain Vehicle Chinese Language Webinar. The webinar will focus on CPSC's...will be held live via webinar. Chinese language speakers can access the webinar at...

2010-02-04

476

Course: Chinese Language and Cultural Experience Course Syllabus  

E-print Network

. The students are expected to master the phonetic system of Chinese, including the sounds, the tones be able to: A. Master the pronunciation of Chinese and be familiar with the phonetic system of Chinese; B

Guo, Zaoyang

477

CEPP regimen (cyclophosphamide, etoposide, procarbazine and prednisone) as initial treatment for Hodgkin lymphoma patients presenting with severe abnormal liver function  

PubMed Central

ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to initial therapy, especially in the presence of renal and liver failure. We hereby present two cases of young male patients with atypical presentation of Hodgkin lymphoma with severe abnormal liver function. Patients showed excellent response to cyclophosphamide, etoposide, procarbazine and prednisone (CEPP regimen). PMID:24991411

2014-01-01

478

Non-Hodgkin's lymphoma and family history of malignant tumors in a case-control study (United States)  

Microsoft Academic Search

Using data froma case-control study in the United States (the Selected Cancers Study), weexamined the relationship between non-Hodgkin's lymphoma (NHL) and family history of different cancers. Cases were 1,511 men aged 31 to 59 years and diagnosed pathologically with non-Hodgkin's lymphoma during 1984-88. Controls were men, frequency-matched to cases by age range and cancer registry (n = 1,910). All study

Kangmin Zhu; Robert S. Levine; Yuan Gu; Edward A. Brann; Irene Hall; Lee S. Caplan; Marianna K. Baum

1998-01-01

479

A mistletoe lectin (ML1)-containing diet reduces the viability of a murine non-Hodgkin lymphoma tumor  

Microsoft Academic Search

In this study we show that the characteristics of non-Hodgkin lymphoma (NHL) tumors in female Naval Medical Research Institute (NMRI, USA) mice fed mistletoe lectin (ML)-containing diets were different from those in mice fed control diet. The non-Hodgkin lymphoma tumor was originally established from a spontaneous tumor which developed in the inguinal region of a male mouse. Mice (five animals

Ian F Pryme; Susan Bardocz; Arpad Pusztai; Stanley W Ewen; Uwe Pfüller

2004-01-01

480

CEPP regimen (cyclophosphamide, etoposide, procarbazine and prednisone) as initial treatment for Hodgkin lymphoma patients presenting with severe abnormal liver function.  

PubMed

ABVD regimen (doxorubicin, bleomycin, vinblastine and dacarbazine) remains the most commonly used front-line therapy for Hodgkin lymphoma. However, atypical and extranodal presentations present challenges to initial therapy, especially in the presence of renal and liver failure. We hereby present two cases of young male patients with atypical presentation of Hodgkin lymphoma with severe abnormal liver function. Patients showed excellent response to cyclophosphamide, etoposide, procarbazine and prednisone (CEPP regimen). PMID:24991411

Thakar, Keyur; Novero, Aileen; Das, Arundhati; Lisinschi, Adriana; Mehta, Bella; Ahmed, Tauseef; Liu, Delong

2014-01-01

481

Factors influencing the learning of Chinese characters  

Microsoft Academic Search

This survey study, which involved 108 language learners enrolled in first-year Chinese as a foreign language classrooms in the United States, intended to address the research questions, ‘What types of Chinese-character learning strategies do US learners use?’ and ‘Do US learners’ Chinese-character learning strategy use differ based on the following learner differences: (1) Gender, (2) Home background, and (3) Previous

Ko-Yin Sung; Hsiao-Ping Wu

2011-01-01

482

Rewi Alley Scholarship in Chinese Studies REWI ALLEY SCHOLARSHIP IN CHINESE STUDIES REGULATIONS FOR 2013  

E-print Network

Rewi Alley Scholarship in Chinese Studies REWI ALLEY SCHOLARSHIP IN CHINESE STUDIES REGULATIONS FOR 2013 BACKGROUND The Rewi Alley Scholarship in Chinese Studies was established by the Rewi Alley and literary work in China over more than 50 years. The purpose of the Scholarship is to encourage study

Waikato, University of