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1

Targetable oncogenic pathways in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma  

Microsoft Academic Search

Summary  Classical Hodgkin lymphoma is a lymphoid neoplasm consisting of mononuclear Hodgkin and multinuclear Reed-Sternberg cells,\\u000a mostly of B-cell origin, embedded in a non-neoplastic background. Most patients are cured with the current risk- and response\\u000a adapted therapy, albeit a portion of patients either will fail to respond or will relapse. An important drawback, considering\\u000a the healed individuals, is the increasing late

A. Tzankov

2008-01-01

2

Targeted therapy in relapsed classical hodgkin lymphoma.  

PubMed

Although frontline treatment of advanced Hodgkin lymphoma (HL) produces high cure rates, disease either will not respond to or will relapse after initial therapy in approximately a quarter of patients. Many patients with disease relapse can be successfully salvaged with second-line chemotherapy followed by autologous stem cell transplantation (ASCT). Patients whose disease relapses after ASCT are rarely cured. A unique pathophysiologic feature of HL is that the malignant Reed-Sternberg (HRS) cell is rare and resides within a microenvironment of inflammatory and immune-related cells. The recent FDA approval of the anti-CD30 antibody-drug conjugate brentuximab vedotin (BV) for patients with either primary refractory HL or those whose disease relapses after ASCT represents a major advance in therapy. This article focuses on BV and other novel agents that target the HRS cell surface, intracellular signaling pathways, and tumor microenvironment. PMID:23946175

Dinner, Shira; Advani, Ranjana

2013-08-01

3

Classical Hodgkin's disease. Clinical impact of the immunophenotype.  

PubMed Central

Antibodies against CD15, -30, and -20 are often used to support morphological diagnosis of Hodgkin's Disease (HD). The classical HD, i.e., the non-lymphocyte-predominance types, are CD15+, CD30+, and CD20- in general. However, the results for CD15 are less clear-cut in many studies, showing up to 40% of classical HD that lack positivity for this maker. Little is currently known about the relevance of antigen expression in relation to clinical outcome in HD. Therefore, the three markers were analyzed in 1751 cases from the German Hodgkin Study Group, using micro-wave epitope retrieval to optimize staining sensitivity. Eighty-three percent of the cases showed a classical immunophenotype (CD15+, CD30+, CD20-), twelve percent lacked CD15 positivity (CD15-, CD30+, CD20-), and five percent showed other combinations. For 1286 cases, clinical follow-up was available, which revealed significant differences for freedom from treatment failure (P = 0.0022) and overall survival (P = 0.0001) between cases with classical immunophenotype and CD15 negativity (CD30+, CD20-). Multivariate Cox regression using the three markers, age, sex, histology, stage, B-symptoms (fever, sweats, weight loss > 10% of body weight), hemoglobin, and erythrocyte sedimentation rate as factors showed that lack of CD15 expression in classical HD is an independent negative prognostic factor for relapses (P = 0.022) and survival (P = 0.0035). In conclusion, immunohistochemistry is able to identify classical HD cases with unfavorable clinical outcome. Images Figure 5 Figure 6

von Wasielewski, R.; Mengel, M.; Fischer, R.; Hansmann, M. L.; Hubner, K.; Franklin, J.; Tesch, H.; Paulus, U.; Werner, M.; Diehl, V.; Georgii, A.

1997-01-01

4

Classical Hodgkin's lymphoma shows epigenetic features of abortive plasma cell differentiation  

PubMed Central

Background Epigenetic changes are involved in the extinction of the B-cell gene expression program of classical Hodgkin’s lymphoma. However, little is known regarding epigenetic similarities between cells of classical Hodgkin’s lymphoma and plasma cell myeloma, both of which share extinction of the gene expression program of mature B cells. Design and Methods Global histone H3 acetylation patterns were determined in cell lines derived from classical Hodgkin’s lymphoma, plasma cell myeloma and B-cell lymphoma by chromatin immunoprecipitation and subsequent hybridization onto promoter tiling arrays. H3K27 trimethylation was analyzed by chromatin immunoprecipitation and real-time DNA polymerase chain reaction for selected genes. Epigenetic modifications were compared to gene expression data. Results Characteristic B-cell genes were hypoacetylated in classical Hodgkin’s lymphoma and plasma cell myeloma cell lines as demonstrated by comparison of their histone H3 acetylation patterns to those of B-cell lines. However, the number of genes jointly hyperacetylated and expressed in classical Hodgkin’ lymphoma and plasma cell myeloma cell lines, such as IRF4/MUM1 and RYBP, is limited. Moreover, H3K27 trimethylation for selected characteristic B-cell genes revealed that this additional epigenetic silencing is much more prevalent in classical Hodgkin’s lymphoma than in plasma cell myeloma. Conclusions Our epigenetic data support the view that classical Hodgkin’s lymphoma is characterized by abortive plasma cell differentiation with a down-regulation of characteristic B-cell genes but without activation of most genes typical of plasma cells.

Seitz, Volkhard; Thomas, Philippe E.; Zimmermann, Karin; Paul, Ulrike; Ehlers, Anke; Joosten, Maria; Dimitrova, Lora; Lenze, Dido; Sommerfeld, Anke; Oker, Elisabeth; Leser, Ulf; Stein, Harald; Hummel, Michael

2011-01-01

5

The classics of ancient Chinese literature  

Microsoft Academic Search

This essay discusses the ancient Chinese literary classics by borrowing the prospective of “canon” from the studies of Western\\u000a literature. Studying the central issues of establishment, quality, type, and influence of ancient classics, the authors attempt\\u000a to present their ancient history, decadent practices, and their central position in ancient literature and literary criticism.\\u000a Moreover, from a broader perspective of modern

Chengxue Wu; Hongbing Sha

2007-01-01

6

Essays on Monkey: A Classic Chinese Novel  

Microsoft Academic Search

Monkey is one of the masterpieces in the genre of the classic Chinese novel. It has been immensely popular with the general reading public of China since the sixteenth century. Abridged and translated into English in 1943 by Arthur Waley, it has made its way onto the college campuses in the United States, and has been well appreciated. There is

Isabelle Ping-I Mao

1997-01-01

7

Gene expression profiling defines molecular subtypes of classical Hodgkin's disease.  

PubMed

Although the prognosis of Hodgkin's disease is relatively good, around 20% of patients do not benefit from current therapies and succumb to their disease. A large-scale molecular characterization of disease might help improve HD management. Using cDNA arrays, we studied the mRNA expression levels of approximately 1000 selected genes in 34 benign and malignant lymphoid samples including 21 classical Hodgkin's disease (HD) tissue samples. Hierarchical clustering identified three main molecular groups of HD tumours relevant with respect to histology and clinical outcome (response to therapy and survival). Samples from all bad outcome HD (BOHD) patients clustered in one group whereas the two other groups contained most good outcome HD (GOHD) cases. The nodular sclerosis GOHD samples overexpressed genes involved in apoptotic induction and cell signalling, including cytokines, while the BOHD samples were characterized by the upregulation of genes involved in fibroblast activation, angiogenesis, extracellular matrix remodelling, cell proliferation, and the downregulation of tumour suppressor genes. Our results establish a molecular taxonomy of HD correlating with response to therapy and clinical outcome, thereby suggesting the possibility of improving the current prognostic classification. PMID:12082542

Devilard, Elisabeth; Bertucci, François; Trempat, Pascal; Bouabdallah, Reda; Loriod, Béatrice; Giaconia, Aurélia; Brousset, Pierre; Granjeaud, Samuel; Nguyen, Catherine; Birnbaum, Daniel; Birg, Françoise; Houlgatte, Remi; Xerri, Luc

2002-05-01

8

Evolution of classic Hodgkin lymphoma in correlation to changes in the lymphoid organ structure of vertebrates.  

PubMed

In order to integrate evolutionary concepts into lymphoma research we mapped features of classic Hodgkin lymphoma (a disease which has been recently described to be derived from germinal center B-cells) onto a phylogenetic tree of vertebrates. Secondly, we matched the phylogenetic occurrence of classic Hodgkin lymphoma to the changes in the lymphoid organ structure during vertebrate evolution. According to our analysis, classic Hodgkin lymphoma evolved exclusively at the developmental stage of mammals. Interestingly the appearance of Hodgkin lymphoma is correlated to the evolution of germinal centers in mammals. This lends some credit to the hypothesis that genes specific to the germinal center reaction are involved in the pathogenesis of Hodgkin lymphoma. However, as evolution did not stop at the developmental stage of the mammalian stem-species, to a certain extent species with specific differences of classic Hodgkin lymphoma can be expected. One such difference is that classic Hodgkin lymphoma occurs with a significantly higher frequency in humans than in all other mammals. This could be partially due to Epstein-Barr virus (EBV) infection in approximately 40%-50% of Hodgkin disease cases, that is associated with an expression of the EBV-encoded oncogen LMP-1. In conclusion we propose that the mapping of lymphoma related characteristics onto a phylogenetic tree is a valuable new tool in lymphoma research. PMID:12477500

Seitz, V; Hummel, M; Walter, J; Stein, H

2003-01-01

9

Plasma thymus and activation-regulated chemokine as an early response marker in classical Hodgkin's lymphoma  

PubMed Central

Background Plasma thymus and activation-regulated chemokine is a potential biomarker for classical Hodgkin’s lymphoma. To define its value as a marker to monitor treatment response, we correlated serial plasma thymus and activation-regulated chemokine levels with clinical response in newly diagnosed and relapsed classical Hodgkin’s lymphoma patients. Design and Methods Plasma was collected from 60 (39 early stage and 21 advanced stage) newly diagnosed classical Hodgkin’s lymphoma patients before, during, and after treatment, and from 12 relapsed patients before and after treatment. Plasma thymus and activation-regulated chemokine levels were determined by enzyme-linked immunosorbent assay and were related to pre-treatment metabolic tumor volume, as measured by quantification of 2-[18F]fluoro-2-deoxyglucose positron emission tomography images, and to treatment response. Results Baseline plasma thymus and activation-regulated chemokine levels correlated with stage of disease and bulky disease, and more closely with metabolic tumor volume. Response to treatment was observed among 38 of 39 early stage and 19 of 21 advanced stage patients. Reduction in plasma thymus and activation-regulated chemokine to normal range levels could be observed as early as after one cycle of chemotherapy in all responsive patients, while plasma levels remained elevated during and after treatment in the 3 non-responsive patients. Plasma thymus and activation-regulated chemokine was elevated in all 12 relapsed patients at time of relapse and remained elevated after salvage treatment in the 4 non-responsive patients. Conclusions Baseline plasma thymus and activation-regulated chemokine levels correlate with classical Hodgkin’s lymphoma tumor burden and serial levels correlate with response to treatment in patients with classical Hodgkin’s lymphoma.

Plattel, Wouter J.; van den Berg, Anke; Visser, Lydia; van der Graaf, Anne-Marijn; Pruim, Jan; Vos, Hans; Hepkema, Bouke; Diepstra, Arjan; van Imhoff, Gustaaf W.

2012-01-01

10

HLA associations in classical Hodgkin lymphoma: EBV status matters.  

PubMed

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients using a PCR-based sequence-specific oligonucleotide probe (SSOP) hybridization approach. The allele frequencies were compared to HLA typings of more than 6,000 controls. The age of the cHL patients varied between 13 and 81 years with a median of 35 years. Nodular sclerosis subtype was the most common subtype (87%) and EBV was detected in 25% of the cHL patients. HLA-B5 was significantly increased and HLA-DR7 significantly decreased in the total cHL patient population as compared to controls. Two class II associations were observed to be specific for the EBV- cHL population with an increase of HLA-DR2 and HLA-DR5. Allele frequencies of HLA-A1, HLA-B37 and HLA-DR10 were significantly increased in the EBV+ cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in Caucasians. The allele frequency of HLA-A2 was significantly decreased in the EBV+ cHL population. Analysis of haplotypes with a frequency of >1% revealed a significant increase of HLA-A2-B7-DR2 in EBV- cHL as compared to controls. SSOP association analysis revealed significant differences between EBV+ and EBV- cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV+ cHL. Furthermore several new protective and predisposing HLA class I and II associations for the EBV+, the EBV- and the entire cHL population were identified. PMID:22808081

Huang, Xin; Kushekhar, Kushi; Nolte, Ilja; Kooistra, Wierd; Visser, Lydia; Bouwman, Ilby; Kouprie, Niels; Veenstra, Rianne; van Imhoff, Gustaaf; Olver, Bianca; Houlston, Richard S; Poppema, Sibrand; Diepstra, Arjan; Hepkema, Bouke; van den Berg, Anke

2012-07-10

11

Matrix Metalloproteinase-9 Expression by Hodgkin-Reed-Sternberg Cells Is Associated with Reduced Overall Survival in Young Adult Patients with Classical Hodgkin Lymphoma  

PubMed Central

Previous studies have investigated the prognostic relevance of MMP9 in classical Hodgkin lymphoma (cHL), with negative results. However, we have found that MMP9 immunoistochemical expression by Hodgkin-Reed-Sternberg cells is associated with reduced overall survival in a subset of young adult Brazilian patients diagnosed with cHL. Additionally, we have observed that MMP9 expression by neoplastic cells in cHL is associated with EBV positivity. These results may support a rational basis for additional studies on the role of this metalloproteinase as a target for therapy in classical Hodgkin lymphoma.

Campos, Antonio Hugo; Vassallo, Jose; Soares, Fernando Augusto

2013-01-01

12

Primary Refractory and Relapsed Classical Hodgkin Lymphoma - Significance of Differential CD15 Expression in Hodgkin-Reed-Sternberg Cells  

PubMed Central

We recognized a few possible complications of classical Hodgkin lymphoma therapy in a cohort of 209 patients: 8 developed a primary refractory disease (primary progression), 36 showed an early relapse and 21 showed a late relapse. Sialyl-CD15 expression in Hodgkin-Reed-Sternberg cells was significantly more positive in primary refractory Hodgkin lymphoma, which confirms our previously published findings. Bcl-2 showed a significantly lower level of expression in primary refractory disease than in the other follow-up groups. This is in contrast with a previous finding of Bcl-2, associated with a poor prognosis in primary refractory illness. Another category of variables, old age and advanced stages, was significantly different in the various complications but this finding is probably to be expected. We could not demonstrate a difference between the sequels and the control group with regard to several clinical and immunohistochemical markers. Sialyl-CD15 and Bcl-2 expression, in contrast, were confirmed as prognostic factors, mainly of tumor progression into primary refractory disease.

Benharroch, Daniel; Pilosof, Shai; Gopas, Jacob; Levi, Itai

2012-01-01

13

Peripheral blood lymphocyte/monocyte ratio at diagnosis and survival in classical Hodgkin's lymphoma  

PubMed Central

Background Lymphopenia and tumor-associated macrophages are negative prognostic factors for survival in classical Hodgkin’s lymphoma. We, therefore, studied whether the peripheral blood absolute lymphocyte count/absolute monocyte count ratio at diagnosis affects survival in classical Hodgkin’s lymphoma. Design and Methods We studied 476 consecutive patients with classical Hodgkin’s lymphoma followed at the Mayo Clinic from 1974 to 2010. Receiver operating characteristic curves and area under the curve were used to determine cut-off values for the absolute lymphocyte count/absolute monocyte count ratio at diagnosis, while proportional hazards models were used to compare survival based on the absolute lymphocyte count/absolute monocyte count ratio at diagnosis. Results The median follow-up period was 5.6 years (range, 0.1–33.7 years). An absolute lymphocyte count/absolute monocyte count ratio at diagnosis of 1.1 or more was the best cut-off value for survival with an area under the curve of 0.91 (95% confidence interval, 0.86 to 0.96), a sensitivity of 90% (95% confidence interval, 85% to 96%) and specificity of 79% (95% confidence interval, 73% to 88%). Absolute lymphocyte count/absolute monocyte count ratio at diagnosis was an independent prognostic factor for overall survival (hazard ratio, 0.18; 95% confidence interval, 0.08 to 0.38, P<0.0001); lymphoma-specific survival (hazard ratio, 0.10; 95% confidence interval, 0.04 to 0.25, P<0.0001); progression-free survival (hazard ratio, 0.35; 95% confidence interval, 0.18 to 0.66, P<0.002) and time to progression (hazard ratio, 0.27; 95% confidence interval, 0.17 to 0.57, P<0.0006). Conclusions The ratio of absolute lymphocyte count/absolute monocyte count at diagnosis is an independent prognostic factor for survival and provides a single biomarker to predict clinical outcomes in patients with classical Hodgkin’s lymphoma.

Porrata, Luis F.; Ristow, Kay; Colgan, Joseph P.; Habermann, Thomas M.; Witzig, Thomas E.; Inwards, David J.; Ansell, Stephen M.; Micallef, Ivana N.; Johnston, Patrick B.; Nowakowski, Grzegorz S.; Thompson, Carrie; Markovic, Svetomir N.

2012-01-01

14

Phase 2 study of rituximab-ABVD in classical Hodgkin lymphoma  

PubMed Central

In classical Hodgkin lymphoma, circulating clonotypic malignant cells express CD20, which potentially explains the observed activity of rituximab. This multicenter phase 2 study investigated the combination of rituximab-ABVD (doxorubicin, bleomycin, vinblastine, dacarbazine) for stage II-IV untreated classical Hodgkin lymphoma. A goal was to assess the behavior of circulating clonotypic B cells clinically. Of 49 evaluable patients, 69% had stage IIB-IV disease; 8% had CD20+ Hodgkin and Reed-Sternberg cells. Rituximab-ABVD was generally well tolerated. Delivered relative dose intensity was 94% for AVD and 79% for bleomycin. After 6 cycles, 81% of patients were in complete remission. Only 8% received radiation therapy. The actuarial 3-year event-free and overall survival rates were 83% and 98%, respectively. EBV copy number in plasma fell dramatically during cycle 1 in patients with EBV+ tumors. Persistence of detectable circulating clonotypic B cells was associated with a greater relapse frequency (P < .05). Rituximab-ABVD and clonotypic B cells warrant additional study in classical Hodgkin lymphoma. This trial was registered at www.clinicaltrials.gov as NCT00369681.

Jacene, Heather A.; Gocke, Christopher D.; Swinnen, Lode J.; Gladstone, Douglas E.; Perkins, Brandy; Link, Brian K.; Popplewell, Leslie L.; Habermann, Thomas M.; Herman, Joseph M.; Matsui, William H.; Jones, Richard J.; Ambinder, Richard F.

2012-01-01

15

Immunohistochemical markers for tumor associated macrophages and survival in advanced classical Hodgkin's lymphoma  

PubMed Central

A subset of patients with advanced classical Hodgkin’s lymphoma is refractory to standard therapies. Therefore, it is relevant to identify new biologically-based prognostic markers. Recently, tumor associated macrophages have been proposed as a factor that predicts survival, although contradictory results have also been reported. Here we analyzed four macrophage markers (CD68, CD163, LYZ, and STAT1) using immunohistochemistry and automated quantification, in two independent series of advanced classical Hodgkin’s lymphoma (n=266 and 103 patients, respectively). Our results did not confirm that specific macrophage immunohistochemical markers could be used as surrogates for gene expression profiling studies. Survival analyses did not show correlation between CD163, LYZ or STAT1 and either failure-free or disease-specific survival. There was an association between CD68 and disease-specific survival, but it was not consistent in both series. In conclusion, individual tumor associated macrophage markers cannot be used to predict outcome before technical standardization and prospective validation in independent series of patients with comparable stages and treatments.

Sanchez-Espiridion, Beatriz; Martin-Moreno, Ana M.; Montalban, Carlos; Medeiros, L. Jeffrey; Vega, Francisco; Younes, Anas; Piris, Miguel A.; Garcia, Juan F.

2012-01-01

16

BCL2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens  

Microsoft Academic Search

To determine the clinical significance of BCL-2 expression in Hodgkin-Reed-Stern- berg (HRS) cells of classical Hodgkin disease (cHD), we correlated its expres- sion with presenting clinical and labora- tory features and failure-free survival (FFS). Eligible patients were untreated and negative for HIV-1; they had biopsy- proven cHD. BCL-2 expression was deter- mined immunohistochemically in available pretreatment tissue biopsy specimens with-

George Z. Rassidakis; L. Jeffrey Medeiros; Theodoros P. Vassilakopoulos; Simonetta Viviani; Valeria Bonfante; Gianpaolo Nadali; Marco Herling; Maria K. Angelopoulou; Roberto Giardini; Marco Chilosi; Christos Kittas; Timothy J. McDonnell; Gianni Bonadonna; Alessandro M. Gianni; Giovanni Pizzolo; Gerassimos A. Pangalis; Fernando Cabanillas; Andreas H. Sarris

2002-01-01

17

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma without mediastinal disease: mimicking nodular sclerosis classical Hodgkin lymphoma.  

PubMed

B-cell lymphoma, unclassifiable, with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma (BCLu-DLBCL/CHL), also known as gray-zone lymphoma, has overlapping clinical and biological characteristics of both diffuse large B-cell lymphoma and classical Hodgkin lymphoma (CHL). These lymphomas are typically associated with mediastinal disease, and extranodal involvement is rare. In the present report, we describe a case of a 78-year-old woman with BCLu-DLBCL/CHL found to have extranodal lesions and no evidence of mediastinal disease. Although biopsy specimens were histologically similar to nodular sclerosis CHL, the tumor cells were positive for CD30 and mature B-cell markers, such as CD20, CD79a, PAX5, BOB.1, and OCT-2, but negative for CD15. Furthermore, the patient had extranodal lesions and an increased level of soluble IL-2 receptor. These findings are unusual in CHL. Therefore, we diagnosed the patient with BCLu-DLBCL/CHL. She received adriamycin, bleomycin, vincristine, and dacarbazine therapy and exhibited partial response. Some cases without mediastinal disease, such as our case, have been reported; however, these cases are rare and further studies are required. PMID:23512149

Iwaki, Noriko; Sato, Yasuharu; Kurokawa, Toshiro; Maeda, Yoshinobu; Ohno, Kyotaro; Takeuchi, Mai; Takata, Katsuyoshi; Orita, Yorihisa; Nakao, Shinji; Yoshino, Tadashi

2013-03-20

18

Cytotoxic molecule-positive classical Hodgkin's lymphoma: a clinicopathological comparison with cytotoxic molecule-positive peripheral T-cell lymphoma of not otherwise specified type  

PubMed Central

Background Classical Hodgkin’s lymphoma is characterized by Hodgkin and Reed Sternberg cells, which are of B-cell origin in many cases. We recently highlighted the adverse prognostic significance of cytotoxic molecule expression in patients with classical Hodgkin’s lymphoma. However, the clinical characteristics of cytotoxic molecule-positive classical Hodgkin’s lymphoma remain controversial. Design and Methods We investigated the clinicopathological profiles of 32 patients with cytotoxic molecule-positive Hodgkin’s lymphoma, comprising 23 with nodular sclerosis and 9 with mixed cellularity, and compared these profiles with those of 55 patients with cytotoxic molecule-positive nodal peripheral T-cell lymphoma, not otherwise specified and 439 patients with cytotoxic molecule-negative Hodgkin’s lymphoma. Results The patients with cytotoxic molecule-positive Hodgkin’s lymphoma consisted of 20 men and 12 women with a median age of 50 years (range, 19 to 81). All these patients had lymphadenopathy at presentation, and 14 showed mediastinal involvement. Physical findings included hepatomegaly and splenomegaly in six patients each. Four patients had a bulky mass, and nine showed stage IV disease. The tumor cells of patients with cytotoxic molecule-positive Hodgkin’s lymphoma had a prototypic immunophenotype of CD15+ CD30+ CD45RO? fascin+, with positivity for Epstein-Barr virus in 39% of cases. All patients were negative for Pax5. In comparison with patients with cytotoxic molecule-positive nodal peripheral T-cell lymphomas, not otherwise specified, patients with cytotoxic-positive Hodgkin’s lymphoma had relatively mild clinical symptoms, similar to those of patients with cytotoxic molecule-negative Hodgkin’s lymphoma. Regarding prognosis, the survival of patients with cytotoxic molecule-positive Hodgkin’s lymphoma was worse than that of patients with cytotoxic molecule-negative Hodgkin’s lymphoma (P=0.0003) but better than that of patients with cytotoxic molecule-positive peripheral T-cell lymphomas, not otherwise specified (P=0.002). Conclusions Cytotoxic molecule-positive Hodgkin’s lymphoma is characterized by an unfavorable prognosis, even if its clinicopathological features are within the boundaries of classical Hodgkin’s lymphoma. More effective chemotherapy for cytotoxic molecule-positive Hodgkin’s lymphoma is clearly required.

Asano, Naoko; Kinoshita, Tomohiro; Tamaru, Jun-Ichi; Ohshima, Koichi; Yoshino, Tadashi; Niitsu, Nozomi; Tsukamoto, Norifumi; Hirabayashi, Kaoru; Izutsu, Koji; Taniwaki, Masafumi; Morishima, Yasuo; Nakamura, Shigeo

2011-01-01

19

Chromosomal breakpoints affecting immunoglobulin loci are recurrent in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.  

PubMed

Chromosomal breakpoints affecting immunoglobulin (IG) loci are recurrent in many subtypes of B-cell lymphomas. However, despite the predominant B-cell origin of the Hodgkin and Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL), the presence of chromosomal translocations in IG loci has not yet been systematically explored. Therefore, we have investigated a series of cHL for chromosomal breakpoints in the IGH (n = 230), IGL (n = 139), and IGK (n = 138) loci by interphase cytogenetics. Breakpoints in the IGH, IGL, or IGK locus were observed in the HRS cells of 26 of 149 (17%), 2 of 70, and 1 of 77 evaluable cHLs, respectively. The IG partners could be identified in eight cHLs and involved chromosomal bands 2p16 (REL), 3q27 (BCL6, two cases), 8q24.1 (MYC), 14q24.3, 16p13.1, 17q12, and 19q13.2 (BCL3/RELB). In 65 of 85 (76%) cHLs evaluable for an IGH triple-color probe, the HRS cells showed evidence for a (partial) deletion of the IGH constant region, suggesting the presence of class switch recombination (CSR). Furthermore, analyses with this probe in cases with IGH breakpoints indicated that at least part of them seem to be derived from CSR defects. Our results show that chromosomal breakpoints affecting the IG loci are recurrent in cHL. PMID:17079453

Martín-Subero, José I; Klapper, Wolfram; Sotnikova, Anna; Callet-Bauchu, Evelyne; Harder, Lana; Bastard, Christian; Schmitz, Roland; Grohmann, Susanne; Höppner, Jorge; Riemke, Jennifer; Barth, Thomas F E; Berger, Françoise; Bernd, Heinz-Wolfram; Claviez, Alexander; Gesk, Stefan; Frank, Georgiy A; Kaplanskaya, Irina B; Möller, Peter; Parwaresch, Reza M; Rüdiger, Thomas; Stein, Harald; Küppers, Ralf; Hansmann, Martin L; Siebert, Reiner

2006-11-01

20

A Chinese Classic on Individual Differences  

Microsoft Academic Search

The ability to classify--creative ability-expressive ability--these are not abilities found in some factor analysis, but they are among the eight talents described by the Chinese sage, Liu Shao, sometime between 240 and 250 A.D. in a book which deserves mention in psychological literature. Because these comments are based on an English translation which is provided with an extensive commentary, only

Steven G. Vandenberg

1956-01-01

21

ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma.  

PubMed

We report on two sibs with ICF syndrome (immunodeficiency, centromeric heterochromatin instability, and facial anomalies) diagnosed in the elder brother based on the typical chromosomal abnormalities present in 56% of metaphases from cultured lymphocytes. In a previous cytogenetic analysis this diagnosis had been missed due to low manifestation of the ICF chromosomal phenotype. Hypomethylation of classical satellites 2 and 3, and of alpha-satellite DNA was shown in the lymphocytes of the younger sister. At 7 years of age the boy presented with hemiplegia due to tumerous invasion of the right brachial plexus. Histopathology revealed classical Hodgkin lymphoma, a neoplasia which might have been facilitated by the underlying genetic defect. PMID:17702009

Schuetz, C; Barbi, G; Barth, T F E; Hoenig, M; Schulz, A; Möeller, P; Smeets, D; de Greef, J C; van der Maarel, S M; Vogel, W; Debatin, K-M; Friedrich, W

2007-09-01

22

Classical Chinese Landscape Painting and the Aesthetic Appreciation of Nature  

ERIC Educational Resources Information Center

Recent theories of the aesthetic appreciation of nature or natural environments have done much to clarify what might be essential to such appreciation. Such accounts are incomplete, however, as they depend on a strict separation between works of art and nature itself. This paper shows how classical Chinese landscape painting offers a way to…

Turner, Matthew

2009-01-01

23

Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma.  

PubMed

An association between classical Hodgkin lymphoma (cHL) and mycosis fungoides (MF) or lymphomatoid papulosis has been reported in the literature. However, there can be considerable morphologic and immunophenotypic overlap between cHL and nodal involvement by CD30-positive T-cell lymphoproliferative disorders (CD30-T-LPD). To examine this potential association, biopsies from patients with a history of MF or primary cutaneous CD30-T-LPD and lymph node biopsies reported as either CD30-positive T-cell lymphoma (TCL) with Hodgkin-like cells or cHL were retrieved from the authors' institution. Of 11 cases identified, 10 were considered CD30-positive TCL with Hodgkin-like cells, whereas 1 was confirmed as cHL upon review. Five cases originally diagnosed as cHL were revised as CD30-positive TCL. Cases of CD30-positive TCL with Hodgkin-like cells showed a male predominance (M:F, 4:1) with a median age of 53 years (range, 44 to 72 y). Nearly all patients (9/10) initially presented with skin lesions. In 7/10 patients the draining lymph node was involved, whereas in 3 cases this could not be confirmed. Tumor cells morphologically resembled Hodgkin/Reed-Sternberg cells; they were uniformly strongly positive for CD30, and CD15 was expressed in 9/10 (90%) cases. A T-cell derivation was confirmed by T-cell antigen expression (7/10) and clonal rearrangement of T-cell receptor genes (9/10). In 3 cases a common T-cell clone was identified in skin and lymph node. B-cell markers (CD20/PAX5) were consistently negative. In 1 case the diagnosis of cHL followed by lymphomatoid papulosis was confirmed, with Hodgkin/Reed-Sternberg cells expressing PAX5, CD30, and CD15. In situ hybridization studies for Epstein Barr virus were negative. We show that cHL is less often associated with MF and primary cutaneous CD30-T-LPD than previously thought and that the coexpression of CD30 and CD15 in these TCLs may lead to a mistaken diagnosis of cHL. PMID:22367293

Eberle, Franziska C; Song, Joo Y; Xi, Liqiang; Raffeld, Mark; Harris, Nancy Lee; Wilson, Wyndham H; Pittaluga, Stefania; Jaffe, Elaine S

2012-05-01

24

Follicular peripheral T-cell lymphoma expands the spectrum of classical Hodgkin lymphoma mimics.  

PubMed

Epstein-Barr virus (EBV)-infected B cells with Reed-Sternberg-like cell (RS) features may occur in peripheral T-cell lymphomas (PTCLs), especially in angioimmunoblastic T-cell lymphoma. Here, we report 5 patients presenting with lymphadenopathy whose first biopsies demonstrated nodular lymphoid proliferations containing scattered CD30+, CD15+, EBV+ Hodgkin and Reed-Sternberg-like cells, which led to an initial diagnosis of lymphocyte-rich classical Hodgkin lymphoma. However, the uncommon clinical features and/or the occurrence of relapse as PTCL prompted review of the biopsies with expanded immunohistologic and molecular studies and revision of the diagnoses to follicular variant of PTCL (F-PTCL). All cases had atypical small to medium-sized CD3+ T cells that expressed CD10 (4/5) and the follicular helper T-cell (TFH) antigens BCL6, PD1, CXCL13, and ICOS. All demonstrated clonal T cells with a similar pattern in multiple samples from 4 patients. In 2 cases, flow cytometry demonstrated circulating lymphocytes with an abnormal sCD3+, CD4+, ICOS+ immunophenotype. Two patients had a skin rash at presentation, and 1 had B symptoms. Two of the 4 patients treated with polychemotherapy are alive at 3 and 6 years after first diagnosis. These cases highlight how some F-PTCLs may closely mimic lymphocyte-rich classical Hodgkin lymphoma requiring careful assessment of the T cells before rendering the latter diagnosis. The functional properties of TFH cells might lead to the presence of EBV-positive B blasts with RS-like features in TFH-derived PTCL such as angioimmunoblastic T-cell lymphoma and F-PTCL. PMID:23073322

Moroch, Julien; Copie-Bergman, Christiane; de Leval, Laurence; Plonquet, Anne; Martin-Garcia, Nadine; Delfau-Larue, Marie-Hélène; Molinier-Frenkel, Valérie; Belhadj, Karim; Haioun, Corinne; Audouin, Josée; Swerdlow, Steven H; Marafioti, Teresa; Gaulard, Philippe

2012-11-01

25

Nodal involvement by cutaneous CD30-positive T-cell lymphoma mimicking classical Hodgkin lymphoma  

PubMed Central

An association between classical Hodgkin lymphoma (cHL) and mycosis fungoides (MF) or lymphomatoid papulosis (LyP) has been reported in the literature. However, there can be considerable morphologic and immunophenotypic overlap between cHL and nodal involvement by CD30-positive T-cell lymphoproliferative disorders (T-LPD). To examine this potential association, biopsies from patients with a prior history of MF or primary cutaneous CD30-positive T-LPD and lymph node biopsies reported as either CD30-positive T-cell lymphoma (TCL) with Hodgkin-like cells or cHL were retrieved from the authors’ institution. Of 11 cases identified, 10 were considered CD30-positive TCL with Hodgkin-like cells, while one was confirmed as cHL upon review. Five cases originally diagnosed as cHL were revised as CD30-positive TCL. Cases of CD30-positive TCL with Hodgkin-like cells showed a male predominance (M:F, 4:1) with a median age of 53 years (range 44-72 years). Nearly all patients (9/10) initially presented with skin lesions. In 7/10 patients the draining lymph node was involved, whereas in 3 cases this could not be confirmed. Tumor cells morphologically resembled Hodgkin/Reed-Sternberg (HRS) cells; they were uniformly strongly positive for CD30 and CD15 was expressed in 9/10 (90%) of cases. A T-cell derivation was confirmed by T-cell antigen expression (7/10) and clonal rearrangement of T-cell receptor genes (9/10). In three cases a common T-cell clone was identified in skin and lymph node. B-cell markers (CD20/PAX5) were consistently negative. In one case the diagnosis of cHL followed by LyP was confirmed, with HRS-cells expressing PAX5, CD30 and CD15. In situ hybridization studies for EBV were negative. We show that cHL is less often associated with MF and primary cutaneous CD30-positive T-cell LPD than previously thought, and that the co-expression of CD30 and CD15 in these T-cell lymphomas may lead to a mistaken diagnosis of cHL.

Eberle, Franziska C.; Song, Joo Y.; Xi, Liqiang; Raffeld, Mark; Harris, Nancy Lee; Wilson, Wyndham H.; Pittaluga, Stefania; Jaffe, Elaine S.

2012-01-01

26

Prognostic Significance of New Immunohistochemical Markers in Refractory Classical Hodgkin Lymphoma: A Study of 59 Cases  

PubMed Central

Although most classical Hodgkin lymphoma patients are cured, a significant minority fail after primary therapy and may die as result of their disease. To date, there is no consensus on biological markers that add value to usual parameters (which comprise the International Prognostic Score) used at diagnosis to predict outcome. We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders) for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi-quantitative immunohistochemical study and correlated the results with the response to treatment. The results showed that expression of bcl2 and CD20 in Hodgkin and Reed Sternberg cells, and expression of TiA1 in micro-environmental lymphocytes, and c-kit positive mast cells in microenvironment, were independent prognostic markers. These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups.

Taupin, Pierre; Ribrag, Vincent; Delarue, Richard; Bosq, Jacques; Rubio, Marie-Therese; Roux, Damien; Vasiliu, Viorel; Varet, Bruno; Brousse, Nicole; Hermine, Olivier

2009-01-01

27

Prognostic significance of new immunohistochemical markers in refractory classical Hodgkin lymphoma: a study of 59 cases.  

PubMed

Although most classical Hodgkin lymphoma patients are cured, a significant minority fail after primary therapy and may die as result of their disease. To date, there is no consensus on biological markers that add value to usual parameters (which comprise the International Prognostic Score) used at diagnosis to predict outcome. We evaluated 59 patients (18 with primary refractory or early relapse disease and 41 responders) for bcl2, Ki67, CD20, TiA1 and c-kit expression by semi-quantitative immunohistochemical study and correlated the results with the response to treatment.The results showed that expression of bcl2 and CD20 in Hodgkin and Reed Sternberg cells, and expression of TiA1 in micro-environmental lymphocytes, and c-kit positive mast cells in microenvironment, were independent prognostic markers. These novel cHL markers could be used in association with clinical parameters to identify newly diagnosed patients with favorable or unfavorable prognosis and to better tailor treatment for different risk groups. PMID:19623262

Canioni, Danielle; Deau-Fischer, Bénédicte; Taupin, Pierre; Ribrag, Vincent; Delarue, Richard; Bosq, Jacques; Rubio, Marie-Thérèse; Roux, Damien; Vasiliu, Viorel; Varet, Bruno; Brousse, Nicole; Hermine, Olivier

2009-07-22

28

Development of classical Hodgkin's lymphoma in an adult with biallelic STXBP2 mutations  

PubMed Central

Experimental model systems have delineated an important role for cytotoxic lymphocytes in the immunosurveillance of cancer. In humans, perforin-deficiency has been associated with occurrence of hematologic malignancies. Here, we describe an Epstein-Barr virus-positive classical Hodgkin’s lymphoma in a patient harboring biallelic mutations in STXBP2, a gene required for exocytosis of perforin-containing lytic granules and associated with familial hemophagocytic lymphohistocytosis. Cytotoxic T lymphocytes were found infiltrating the tumor, and a high frequency of Epstein-Barr virus-specific cytotoxic T lymphocytes were detected in peripheral blood. However, lytic granule exocytosis and cytotoxicity by cytotoxic T lymphocytes, as well as natural killer cells, were severely impaired in the patient. Thus, the data suggest a link between defective lymphocyte exocytosis and development of lymphoma in STXBP2-deficient patients. Therefore, with regards to treatment of familial hemophagocytic lymphohistocytosis patients with mutations in genes required for lymphocyte exocytosis, it is important to consider both the risks of hemophagocytic lymphohistocytosis and malignancy.

Machaczka, Maciej; Klimkowska, Monika; Chiang, Samuel C.C.; Meeths, Marie; Muller, Martha-Lena; Gustafsson, Britt; Henter, Jan-Inge; Bryceson, Yenan T.

2013-01-01

29

Prognostic role of tumor-associated macrophages and angiogenesis in classical Hodgkin lymphoma.  

PubMed

Abstract We studied by immunohistochemistry CD68 + tumor-associated macrophages (TAMs) and angiogenesis in 121 consecutive cases of uniformly treated classical Hodgkin lymphoma (cHL). High TAM count showed a significant correlation with age ? 45, mixed cellularity subtype and high ?2-microglobulin level. Vessel density (VD) was unrelated to clinicopathological features, while a significant correlation was found between TAM count and VD. Patients with high TAMs showed a trend toward reduced progression-free survival and significantly shorter overall survival (OS). No correlation was found between VD and survival. At multivariate analysis, bulky disease was an independent predictor of reduced progression-free survival, while independent adverse prognostic factors for OS were male sex, age ? 45, advanced stage and bulky disease. High TAM count results in an adverse overall outcome in cHL and is significantly correlated to VD. Since VD has no prognostic relevance, the adverse effect of TAMs is presumably unrelated to angiogenesis. PMID:23432688

Panico, Luigi; Ronconi, Fioravante; Lepore, Marianna; Tenneriello, Valentina; Cantore, Nicola; Dell'angelo, Antonietta Carmela; Ferbo, Umberto; Ferrara, Felicetto

2013-04-11

30

MET and MST1R as prognostic factors for classical Hodgkin's lymphoma.  

PubMed

MST1R (RON) and MET are receptor tyrosine kinase gene family members that form a noncovalent complex on the cell surface, a critical step in tumor progression. A recent study suggested a prognostic role of MET expression in Hodgkin/Reed-Sternberg (HRS) cells in classical Hodgkin's lymphoma (cHL). The purpose of this study was to examine the prognostic significance of MET and MST1R expression in cHL. The prognostic impact of MET and MST1R was examined in 100 patients with cHL (median age: 32 years) by immunohistochemistry and mRNA in situ hybridization. The median follow-up time was 95 months (interquartile range: 42-126 months). MET or MST1R protein expression was associated with high MET or MST1R mRNA expression, respectively. Thirty-eight patients (38%) expressed MET protein in HRS cell, which was associated with better overall survival (P=0.004). Twenty-six patients (26%) expressed MST1R protein, which was associated with better overall survival (P=0.022) and event-free survival (P=0.021). Multivariate analysis identified MET protein as an independent prognostic factor for overall survival and MST1R protein as an independent prognostic factor for event-free survival. Subgroup analysis according to Ann Arbor stage showed that expressions of MET and MST1R protein have prognostic impact in the advanced stage only. In particular, coexpression of MST1R and MET protein was associated with a better survival outcome than MET or MST1R expression alone or no expression. This study suggests that MET and MST1R are independent prognostic factors in classical cHL, and may allow the identification of a subgroup of cHL patients who require more intensive therapy. PMID:23558571

Wha Koh, Young; Park, Chansik; Hyun Yoon, Dok; Suh, Cheolwon; Huh, Jooryung

2013-04-05

31

Hodgkin’s Lymphoma  

Microsoft Academic Search

\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a An estimated 8,490 new cases of Hodgkin’s lymphoma were diagnosed in the USA in 2010.\\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Reed–Sternberg cells are the malignant cells in classical Hodgkin’s lymphoma (CD15+, CD30+, and CD45?). In nodular lymphocyte-predominant\\u000a Hodgkin’s lymphoma (NLPHL), these cells express B-cell markers (CD20+, CD79a+, and CD45+) and are CD15? and CD30?.\\u000a \\u000a \\u000a \\u000a \\u000a • \\u000a \\u000a \\u000a Common presentation is an asymptomatic lymph node enlargement

Maryse Bernard; Richard W. Tsang

32

Classical Hodgkin lymphoma arising in the setting of iatrogenic immunodeficiency: a clinicopathologic study of 10 cases.  

PubMed

Iatrogenic immunodeficiency-associated lymphoproliferative disorders are rare. A small subset of these lesions resembles classical Hodgkin lymphoma (CHL), but there are few data in the literature about these lesions. We describe 10 patients with autoimmune diseases treated with immunomodulator therapeutic agents who developed CHL. The autoimmune diseases included rheumatoid arthritis (n=5), systemic lupus erythematosus (n=2), dermatomyositis (n=1), autoimmune hepatitis (n=1), and Crohn disease (n=1), and the immunomodulatory therapies were methotrexate, azathioprine, tumor necrosis factor-? inhibitors, and thalidomide alone or in various combinations. The study group included 9 women and 1 man with a median age of 50 years (range, 25 to 77 y). The histologic features supported CHL in all cases with Reed-Sternberg (RS) and Hodgkin (H) cells in an inflammatory cell background, although the neoplasm could only be subclassified in 3 patients: 2 nodular sclerosis and 1 mixed cellularity. Immunohistochemical analysis supported the diagnosis of CHL. In all cases the RS-H cells were CD30. Nine of 10 cases were CD15, whereas CD20 was expressed variably in 4/10 cases. CD45/LCA was negative in 8 cases assessed. In situ hybridization for Epstein-Barr virus-encoded RNA was positive in the RS-H cells in 8/10 cases. The microenvironment of these lesions depicted a predominance of T-regulatory cells and M2 histiocytes. Clinical follow-up data were available for 7 patients, with a median posttreatment period of 27 months (range, 12 mo to 7 y). In all 7 patients immunomodulatory drug therapy was discontinued, and chemotherapy for CHL was administered; 2 patients also received local radiation. All 7 patients achieved complete remission and are alive. We conclude that iatrogenic immunodeficiency-associated CHL is highly associated with Epstein-Barr virus infection, and patients usually have a good outcome after discontinuation of immunomodulatory agents and chemotherapy for CHL. PMID:23774171

Loo, Eric Y; Medeiros, L Jeffrey; Aladily, Tariq N; Hoehn, Daniela; Kanagal-Shamanna, Rashmi; Young, Ken H; Lin, Pei; Bueso-Ramos, Carlos E; Manning, John T; Patel, Keyur; Thomazy, Vilmos; Brynes, Russell K; Goswami, Maitrayee; Fayad, Luis E; Miranda, Roberto N

2013-08-01

33

MicroRNA signatures and treatment response in patients with advanced classical Hodgkin lymphoma.  

PubMed

Although specific microRNA (miRNA) signatures in classical Hodgkin lymphoma (cHL) have been proposed, their relationship with clinical outcome remains unclear. Despite treatment advances, a substantial subset of patients with advanced cHL are refractory to standard therapies based on adriamycin and its variants. Global miRNA expression data of 29 advanced cHL patients and five cHL-derived cell lines were used to identify profiles from Hodgkin-Reed-Sternberg (HRS) cells and their non-tumoural microenvironment. A cHL-miRNA signature was identified with 234 miRNAs differentially expressed. A subset of these miRNAs was associated with outcome and selected for study in an independent set of 168 cHL samples using quantitative reverse transcription polymerase chain reaction. Multivariate Cox regression analyses including cross-validation with failure-free survival (FFS) as clinical endpoint revealed a miRNA signature with MIR21, MIR30E, MIR30D and MIR92B* that identified two risk-groups with significant differences in 5-year FFS (81% vs. 35.7%; P < 0.001). Additionally, functional silencing of MIR21 and MIR30D in L428 cells showed increased sensitivity to doxorubicin-induced apoptosis, pointing towards abnormalities of mitochondrial intrinsic and TP53-CDKN1A pathways as related to miRNA deregulation in cHL. These results suggest that clinical outcome in cHL is associated with a specific miRNA signature. Moreover, functional analyses suggest a role for MIR21 and MIR30D in cHL pathogenesis and therapeutic resistance. PMID:23725219

Sánchez-Espiridión, Beatriz; Martín-Moreno, Ana M; Montalbán, Carlos; Figueroa, Vianihuini; Vega, Francisco; Younes, Anas; Medeiros, L Jeffrey; Alvés, Francisco J; Canales, Miguel; Estévez, Mónica; Menarguez, Javier; Sabín, Pilar; Ruiz-Marcellán, María C; Lopez, Andrés; Sánchez-Godoy, Pedro; Burgos, Fernando; Santonja, Carlos; López, José L; Piris, Miguel A; Garcia, Juan F

2013-06-01

34

Defining characteristics of classical Hodgkin lymphoma microenvironment T-helper cells.  

PubMed

CD4(+) T-helper cells (THs) dominate the classical Hodgkin lymphoma (CHL) microenvironment, but their role is poorly understood. Advances in flow cytometry and immunohistochemistry permit more detailed investigation of this aspect of CHL pathophysiology. To address the hypothesis that the TH-infiltrate, rather than being TH2-enriched, senescent and hypofunctional, is TH1 and activation marker-rich, cytokine-secretory and proliferative, we applied comprehensive flow cytometric immunophenotyping and functional assays of cytokine secretion/proliferation to TH cells from 18 CHL-derived single-cell suspensions (SCSs) compared to reactive lymph nodes (RLNs). CHL-derived TH cells express TH1-associated CXCR3/CCR5 and TNF?/IFN?/interleukin-2 (IL-2) and less TH2-associated CCR3/CCR4, with no IL-4/IL-13. They lack exhaustion-/suppression-associated PD1, CD57 and terminally differentiated effector memory cells, with more central memory cells, activation-associated partners of Hodgkin Reed Sternberg (HRS) cell-expressed CD30/OX40-L/ICOS-L, and other activation markers. TH cell lines established from CHL and RLN-derived SCSs remain cytokine-secretory. We confirmed and extended these studies using tissue microarray immunohistochemistry (TMA-IHC) from a large CHL tissue bank (n = 122) and demonstrate TH1-associated TBET is abundant in CHL, and TH2-associated CMAF/GATA3 and exhaustion-associated PD1 expressed at significantly lower levels. These molecular insights into the CHL-associated TH offer potential diagnostic, prognostic and pharmacologically modifiable therapeutic targets and do not support the established view of a TH2-enriched, senescent/exhausted, hypofunctional, hypoproliferative infiltrate. PMID:24004665

Greaves, Paul; Clear, Andrew; Owen, Andrew; Iqbal, Sameena; Lee, Abigail; Matthews, Janet; Wilson, Andrew; Calaminici, Maria; Gribben, John G

2013-09-04

35

[U-HO1. A new cell line derived from a primary refractory classical Hodgkin lymphoma].  

PubMed

The Hodgkin cell line U-HO1 was established from a malignant pleural effusion of a 23-yr-old male patient during the end stage of refractory nodular sclerosing classical Hodgkin lymphoma (cHL). Since its establishment in 2005, U-HO1 has maintained stable characteristics in vitro and has a doubling time of about 4 days under standard culture conditions. U-HO1 forms typical Reed/Sternberg cells in suspension, is EBV negative, lacks HLA-ABC- but expresses HLA-D- proteins/CD74 and surface exposes CD15 together with CD30 in the absence of CD19 and CD20. Karyotype analysis of U-HO1 revealed a hyperdiploid karyotype with multiple clonal aberrations. Most significant is an elongated chromosome 2, der(2)t(2;10)(q35;q16.1)add(2)(p13). CGH analysis revealed the following imbalances: ish cgh dim(1)(p13p31)(p12q21), enh(2)(p13p23), dim(4)(q31.3qter), enh(6)(q22q27), enh(12), enh(18),enh(20)(q13.1pter). FISH analysis showed about six-fold amplification of REL and BCL-11A, thus, U-HO1 is prototypical for cHL in every aspect tested so far. Compared to other HL cell lines, U-HO1 proved far less genetically aberrant suggesting that U-HO1's imbalances suffice to cause the full-blown phenotype of primary refractory cHL. PMID:18820924

Möller, P; Mader, A; Barth, T F E; Brüderlein, S

2008-11-01

36

Phase 2 study of rituximab plus ABVD in patients with newly diagnosed classical Hodgkin lymphoma  

PubMed Central

In the present study, we evaluated the efficacy and safety of rituximab in combination with standard doxorubicin, bleomycin, vinblastine, and dacarbazine (RABVD) in patients with classical Hodgkin lymphoma (cHL). In this phase 2 study, patients with chemotherapy-naive, advanced-stage cHL were treated with rituximab 375 mg/m2 weekly for 6 weeks and standard ABVD for 6 cycles. The primary outcome was event-free survival (EFS) at 5 years. Eighty-five patients were enrolled, of whom 78 were eligible. With a median follow-up duration of 68 months (range, 26-110), and based on an intent-to-treat analysis, the 5-year EFS and overall survival rates were 83% and 96%, respectively. The 5-year EFS for patients with stage III/IV cHLwas 82%. Furthermore, the 5-year EFS for patients with an International Prognostic Score of 0-2 was 88% and for those with a score of > 2, it was 73%. The most frequent treatment-related grade 3 or 4 adverse events were neutropenia (23%), fatigue (9%), and nausea (8%). Our results demonstrate that the addition of rituximab to ABVD is safe and has a promising clinical activity in patients with advanced-stage cHL. These data are currently being confirmed in a multicenter randomized trial. This trial has been completed and is registered with www.clinicaltrials.gov as NCT00504504.

Oki, Yasuhiro; McLaughlin, Peter; Copeland, Amanda R.; Goy, Andre; Pro, Barbara; Feng, Lei; Yuan, Ying; Chuang, Hubert H.; Macapinlac, Homer A.; Hagemeister, Fredrick; Romaguera, Jorge; Samaniego, Felipe; Fanale, Michelle A.; Dabaja, Bouthaina Shbib; Rodriguez, Maria A.; Dang, Nam; Kwak, Larry W.; Neelapu, Sattva S.; Fayad, Luis E.

2012-01-01

37

Multiple HLA class I and II associations in classical Hodgkin lymphoma and EBV status defined subgroups.  

PubMed

The pathogenesis of classical Hodgkin lymphoma (cHL) involves environmental and genetic factors. To explore the role of the human leukocyte antigen (HLA) genes, we performed a case-control genotyping study in 338 Dutch cHL patients and more than 5000 controls using a PCR-based sequence-specific oligonucleotide probe hybridization approach. HLA-A68 and HLA-DR11 (5) were significantly increased in the cHL patient population compared with the controls. Three class II associations were observed in the EBV(-) cHL population with an increase of HLA-DR15 (2) and a decrease of HLA-DR4 and HLA-DR7. Allele frequencies of HLA-A1, HLA-B37, and HLA-DR10 were significantly increased in the EBV(+) cHL population; these alleles are in strong linkage disequilibrium and form a common haplotype in whites. The allele frequency of HLA-A2 was significantly decreased in the EBV(+) cHL population. Sequence-specific oligonucleotide probe analysis revealed significant differences between EBV(+) and EBV(-) cHL patients for 19 probes that discriminate between HLA-A*01 and HLA-A*02. In conclusion, the HLA-A1 and HLA-A2 antigens and not specific single nucleotide variants shared by multiple alleles are responsible for the association with EBV(+) cHL. Furthermore, several new protective and predisposing HLA class I and II associations for the EBV(+), the EBV(-), and the entire cHL population were identified. PMID:21921049

Huang, Xin; Kushekhar, Kushi; Nolte, Ilja; Kooistra, Wierd; Visser, Lydia; Bouwman, Ilby; Kouprie, Niels; Veenstra, Rianne; van Imhoff, Gustaaf; Olver, Bianca; Houlston, Richard S; Poppema, Sibrand; Diepstra, Arjan; Hepkema, Bouke; van den Berg, Anke

2011-09-14

38

Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease  

Microsoft Academic Search

Recent molecular single-cell studies have shown that in approximately 95% of cases, Reed-Sternberg cells of classic Hodgkin disease (HD) are derived from B cells of germinal center origin. Attempts to determine the cellular nature of the remaining cases have so far failed. To clarify whether they are derived from T cells, this study examined 791 single CD301 Hodgkin and Reed-Sternberg

Volkhard Seitz; Michael Hummel; Theresa Marafioti; Ioannis Anagnostopoulos; Chalid Assaf; Harald Stein

39

Composite diffuse large B-cell lymphoma and classical Hodgkin's lymphoma of the stomach: Case report and literature review  

PubMed Central

The combination of classical Hodgkin’s lymphoma (cHL) and non-Hodgkin lymphoma coexisting in the same patient is not common, especially in one extranodal location. Here we present a rare case of composite diffuse large B-cell lymphoma (DLBCL) and cHL occurring simultaneously in the stomach of a 53-year-old female who presented with upper abdominal discomfort and gas pain. Surgery was performed and the disease was diagnosed pathologically as composite lymphoma of DLBCL and cHL using hematoxylin-eosin and immunohistochemical staining. Epstein-Barr virus (EBV) infection was not detected by in situ hybridization for EBV-encoded RNA or immunohistochemistry for EBV latent membrane protein-1. Polymerase chain reaction analysis from the two distinct components of the tumor demonstrated clonal immunoglobulin ? light chain gene rearrangements. The patient died approximately 11 mo after diagnosis in spite of receiving eight courses of the CHOP and two courses of the rituximab-CHOP (RCHOP) chemotherapy regimen. This case report showed that the two distinct components, DLBCL and cHL, appeared to originate from the same clonal progenitor cell, and that EBV infection was not essential for transformation during the course of tumorigenesis.

Wang, Hong-Wei; Yang, Wen; Wang, Lin; Lu, Yun-Long; Lu, Jiang-Yang

2013-01-01

40

Sphingosine-1-Phosphate Receptor 1 in Classical Hodgkin Lymphoma: Assessment of Expression and Role in Cell Migration  

PubMed Central

Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed Sternberg cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology, the factors which regulate the spread of lymphoma cells in CHL are poorly understood. Sphingosine-1-Phosphate (S1P), a bioactive sphingolipid present at high concentrations in plasma and lymphatic fluid, is known to play a critical role in regulating lymphocyte trafficking mainly through S1PR1. In this study, we explore the role of the S1P-S1PR1 axis in Hodgkin lymphoma cell migration and the expression of S1PR1 in CHL cell lines and clinical cases. We found that S1PR1 is present in the KM-H2 and SUP-HD1 Hodgkin lymphoma cell lines at the mRNA and protein level. In addition, functionally, S1P potently stimulated migration of both cell lines. S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116 and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2 specific antagonist, JTE013. We also determined that S1PR1 induced migration in the KM-H2 and SUP-HD1 cells via the heterotrimeric G protein Gi and the phosphatidylinositol-3-kinase (PI3K) pathway. Immunohistochemical assessment of tissue from CHL samples revealed that a subset of cases (7/57; 12%) show strong, membranous staining for S1PR1 in Hodgkin-Reed Sternberg cells. Altogether our data indicate that S1PR1 is a functional receptor on Hodgkin-Reed Sternberg cells which governs tumor cell migration and is expressed in a subset of CHL cases. Given the availability of S1PR1 antagonists, some of which are used clinically for modulation of the immune system, these results suggest that S1PR1 could be a future therapeutic target in the treatment of those cases of S1PR1-positive, refractory/recurrent CHL.

Kluk, Michael J.; Ryan, Kieran; Wang, Bonnie; Zhang, Guoqi; Rodig, Scott J.; Sanchez, Teresa

2013-01-01

41

Why Chinese People Play Western Classical Music: Transcultural Roots of Music Philosophy  

ERIC Educational Resources Information Center

|This paper addresses the complex relationship between Confucian values and music education in East Asia, particularly its history in China. How does one account for the present "cultural fever" of Western classical music that has infected more than 100 million Chinese practitioners? It is proposed that Western classical music finds transcultural…

Huang, Hao

2012-01-01

42

Why Chinese people play Western classical music: Transcultural roots of music philosophy  

Microsoft Academic Search

This paper addresses the complex relationship between Confucian values and music education in East Asia, particularly its history in China. How does one account for the present ‘cultural fever’ of Western classical music that has infected more than 100 million Chinese practitioners? It is proposed that Western classical music finds transcultural affinities in Confucian traditional values of artful self-cultivation and

Hao Huang

2012-01-01

43

Composite diffuse large B-cell lymphoma and classical Hodgkin's lymphoma of the stomach: Case report and literature review.  

PubMed

The combination of classical Hodgkin's lymphoma (cHL) and non-Hodgkin lymphoma coexisting in the same patient is not common, especially in one extranodal location. Here we present a rare case of composite diffuse large B-cell lymphoma (DLBCL) and cHL occurring simultaneously in the stomach of a 53-year-old female who presented with upper abdominal discomfort and gas pain. Surgery was performed and the disease was diagnosed pathologically as composite lymphoma of DLBCL and cHL using hematoxylin-eosin and immunohistochemical staining. Epstein-Barr virus (EBV) infection was not detected by in situ hybridization for EBV-encoded RNA or immunohistochemistry for EBV latent membrane protein-1. Polymerase chain reaction analysis from the two distinct components of the tumor demonstrated clonal immunoglobulin ? light chain gene rearrangements. The patient died approximately 11 mo after diagnosis in spite of receiving eight courses of the CHOP and two courses of the rituximab-CHOP (RCHOP) chemotherapy regimen. This case report showed that the two distinct components, DLBCL and cHL, appeared to originate from the same clonal progenitor cell, and that EBV infection was not essential for transformation during the course of tumorigenesis. PMID:24115832

Wang, Hong-Wei; Yang, Wen; Wang, Lin; Lu, Yun-Long; Lu, Jiang-Yang

2013-10-01

44

Lack of association of tumor-associated macrophages with clinical outcome in patients with classical Hodgkin's lymphoma  

PubMed Central

Background: A recent study demonstrated that an increased number of CD68+ macrophages were correlated with primary treatment failure, shortened progression-free survival (PFS) and disease-specific survival (DSS) in patients with classical Hodgkin's lymphoma (cHL). Patients and methods: The aim of the present study was to verify the relationship between the number of CD68+ and CD163+ macrophages with clinical outcomes in a cohort of 265 well-characterized patients with cHL treated uniformly with the standard doxorubicin, bleomycin, vinblastine and dacarbazine chemotherapy regimen. Two pairs of hematopathologists carried out independent pathological evaluations of tissue microarray slides. Results: There were no associations between clinical characteristics and the expression of CD68 or CD163. However, higher levels of CD68 and CD163 expression were correlated with the presence of Epstein–Barr virus-positive Hodgkin tumor cells (P = 0.01 and 0.037, respectively). The expression of CD68 or CD163 was not associated with either the PFS or the DSS. Conclusion: CD68 and CD163 expression require further evaluation before their use can be recommended for prognostic stratification of patients with cHL.

Azambuja, D.; Natkunam, Y.; Biasoli, I.; Lossos, I. S.; Anderson, M. W.; Morais, J. C.; Spector, N.

2012-01-01

45

Sphingosine-1-phosphate receptor 1 in classical Hodgkin lymphoma: assessment of expression and role in cell migration.  

PubMed

Classical Hodgkin lymphoma (CHL), a neoplasm of abnormal B lymphocytes (Hodgkin-Reed-Sternberg (HRS) cells), has been described to have a typical pattern of clinical presentation and dissemination often involving functionally contiguous lymph nodes. Despite the progress made in understanding CHL pathophysiology, the factors that regulate the spread of lymphoma cells in CHL are poorly understood. Sphingosine-1-phosphate (S1P), a bioactive sphingolipid present at high concentrations in the plasma and lymphatic fluid, is known to have a critical role in regulating lymphocyte trafficking mainly through sphingosine-1-phosphate receptor 1 (S1PR1). In this study, we explore the role of the S1P-S1PR1 axis in Hodgkin lymphoma cell migration and the expression of S1PR1 in CHL cell lines and clinical cases. We found that S1PR1 is present in the KM-H2 and SUP-HD1 Hodgkin lymphoma cell lines at the mRNA and protein level. In addition, functionally, S1P potently stimulated migration of both cell lines. S1P-induced migration was inhibited by the S1PR1 antagonist, VPC44116, and the S1PR1 functional antagonist, FTY720-P, but was potentiated by the S1PR2-specific antagonist, JTE013. We also determined that S1PR1 induced migration in the KM-H2 and SUP-HD1 cells via the heterotrimeric G-protein Gi and the phosphatidylinositol-3-kinase pathway. Immunohistochemical assessment of the tissue from CHL samples revealed that a subset of cases (7/57; 12%) show strong, membranous staining for S1PR1 in HRS cells. Altogether, our data indicate that S1PR1 is a functional receptor on HRS cells, which governs tumor cell migration and is expressed in a subset of CHL cases. Given the availability of S1PR1 antagonists, some of which are used clinically for modulation of the immune system, these results suggest that S1PR1 could be a future therapeutic target in the treatment of those cases of S1PR1-positive, refractory/recurrent CHL. PMID:23419711

Kluk, Michael J; Ryan, Kieran P; Wang, Bonnie; Zhang, Guoqi; Rodig, Scott J; Sanchez, Teresa

2013-02-18

46

Hodgkin’s lymphoma  

MedlinePLUS

Lymphoma - Hodgkin's; Hodgkin's disease; Cancer - Hodgkin's lymphoma ... The cause is not known. Hodgkin's lymphoma is most common among people ages 15 - 35 and 50 - 70. Past infection with the Epstein-Barr virus ( EBV ) is thought to ...

47

Western generic business and corporate strategies : lessons from the Thirty-six Chinese Classical Strategies of War  

Microsoft Academic Search

Extracts the fundamental principles of the Thirty-six Chinese Classical Strategies of War to formulate an appropriate framework for drawing lessons in Western generic business and corporate strategies for the first time. Does not, however, suggest that Western literature on generic business and corporate strategies is any less effective than the Thirty-six Chinese Classical Strategies of War which tend to be

Low Sui Pheng; Rajeshwar Sirpal

1995-01-01

48

Discriminating Mood Taxonomy of Chinese Traditional Music and Western Classical Music with Content Feature Sets  

Microsoft Academic Search

According to numbers of music cognitive experiments, moods or emotions in music could be categorical. Since mood classifications are commonly used to structure the large collections of music available on the Web, automatic discrimination between mood taxonomy of Chinese traditional music and Western classical music would be a valuable addition to music information retrieval (MIR) systems. In this paper, three

Wen Wu; Lingyun Xie

2008-01-01

49

[Conversion and transformation: the historical destiny of Chinese medicine and Western medicine classics].  

PubMed

Chinese medicine (CM) and Western Medicine (WM) show different traces in the inheritance and innovation. The great distinguished physicians in the history of CM and WM, and eternal classic works have experienced similar fates in the river of the history, but they have manifested the same origins and different branches. In this paper, I hold that it is understandable that CM classics and WM classics have experienced different historical destinies from different disciplinary attributes. Their methodological origins could be found from different ideological and cultural bases. They construct necessary tension of mutual reference and bridging from future development of a medical community. PMID:23359963

Liu, Xiao

2012-11-01

50

B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction.  

PubMed

Recent studies, largely focusing on cellular immunity, have demonstrated that the composition of the abundant inflammatory background of Hodgkin lymphoma may affect outcome. This investigation aimed to characterize the potential role of infiltrating B cells and follicular dendritic cell networks in classical Hodgkin lymphoma (cHL) to better assess the role of components of humoral immunity. One hundred two cHL biopsies were investigated by immunohistochemistry with antibodies specific for CD20, CD138, activation-induced cytidine deaminase, and CD21 to characterize B cell distribution and follicular structures. To further subclassify B cells, analyses of tissue microarrays were performed investigating the expression of Mum1, Bcl6, IgD, IgG, IgG4, IgM, T-bet, CD38, CD5, and CD10. For evaluation a computer assisted quantification method was compared with a scoring system. Survival analysis and correlation analysis were performed. The B cell infiltrate was dominated by CD20+ B cells, followed by plasma cells, whereas only few AID+ cells were observed. High numbers of CD21+ follicular dendritic cell networks, CD20+ B cells, IgM+ cells, CD20+ aggregates, and Bcl6+ cells were associated with a better outcome of cHL patients, whereas Pax5+/CD38+ cells had an adverse prognostic impact. Other parameters showed no influence on survival. Our findings suggest that a complex network of B cells is present in the microenvironment of cHL and that B cells might actively contribute to a local anti- as well as pro-tumoral immune response. This indicates that the network of B cells in tumors is probably just as diverse as the T cellular infiltrate and probably functionally as heterogenous. PMID:24029709

Tudor, Christiane S; Distel, Luitpold V; Eckhardt, Jenny; Hartmann, Arndt; Niedobitek, Gerald; Buettner, Maike

2013-09-10

51

ICF syndrome: high variability of the chromosomal phenotype and association with classical Hodgkin lymphoma  

Microsoft Academic Search

We report on two sibs with ICF syndrome (immunodeficiency, centromeric heterochromatin instability, and facial anomalies) diagnosed in the elder brother based on the typical chromosomal abnormalities present in 56% of metaphases from cultured lymphocytes. In a previous cytogenetic analysis this diagnosis had been missed due to low manifestation of the ICF chromosomal phenotype. Hypomethylation of classical satellites 2 and 3,

C. Schuetz; G. Barbi; T. F. E. Barth; M. Hoenig; A. Schulz; P. Moeller; D. F. C. M. Smeets; J. C. de Greef; S. M. van der Maarel; W. Vogel; K.-M. Debatin; W. Friedrich

2007-01-01

52

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma  

Microsoft Academic Search

Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large B-cell lymphoma (DLBCL) that char- acteristically presents as localized tu- mors in young female patients. Although MLBCL has distinctive pathologic fea- tures, it clinically resembles the nodular sclerosis subtype of classical Hodgkin lymphoma (cHL). To elucidate the molecu- lar features of MLBCL, we compared the gene expression

Kerry J. Savage; Stefano Monti; Jeffery L. Kutok; Giorgio Cattoretti; Donna Neuberg; Laurence de Leval; Paul Kurtin; Paola Dal Cin; Christine Ladd; Friedrich Feuerhake; Ricardo C. T. Aguiar; Sigui Li; Gilles Salles; Francoise Berger; Wen Jing; Geraldine S. Pinkus; Thomas Habermann; Riccardo Dalla-Favera; Lee Harris; Jon C. Aster; Todd R. Golub; Margaret A. Shipp

2003-01-01

53

Inflammation and tissue repair markers distinguish the nodular sclerosis and mixed cellularity subtypes of classical Hodgkin's lymphoma  

PubMed Central

Background: Classical Hodgkin's lymphoma (cHL), although a malignant disease, has many features in common with an inflammatory condition. The aim of this study was to establish the molecular characteristics of the two most common cHL subtypes, nodular sclerosis (NS) and mixed cellularity (MC), based on molecular profiling and immunohistochemistry, with special reference to the inflammatory microenvironment. Methods: We analysed 44 gene expression profiles of cHL whole tumour tissues, 25 cases of NS and 19 cases of MC, using Affymetrix chip technology and immunohistochemistry. Results: In the NS subtype, 152 genes showed a significantly higher expression, including genes involved in extracellular matrix (ECM) remodelling and ECM deposition similar to wound healing. Among these were SPARC, CTSK and COLI. Immunohistochemistry revealed that the NS-related genes were mainly expressed by macrophages and fibroblasts. Fifty-three genes had a higher expression in the MC subtype, including several inflammation-related genes, such as C1Q?, C1Q? and CXCL9. In MC tissues, the C1Q subunits were mainly expressed by infiltrating macrophages. Conclusions and interpretations: We suggest that the identified subtype-specific genes could reflect different phases of wound healing. Our study underlines the potential function of infiltrating macrophages in shaping the cHL tumour microenvironment.

Birgersdotter, A; Baumforth, K R N; Porwit, A; Sjoberg, J; Wei, W; Bjorkholm, M; Murray, P G; Ernberg, I

2009-01-01

54

Molecular profiling of classical Hodgkin lymphoma tissues uncovers variations in the tumor microenvironment and correlations with EBV infection and outcome.  

PubMed

The outcome of classical Hodgkin lymphoma (cHL) patients may be related to the tumor microenvironment, which in turn may be influenced by Epstein-Barr virus (EBV) infection. To characterize the cHL microenvironment, a set of 63 cHL tissue samples was profiled using DNA microarrays. Their gene expression profile differed from that of histiocyte T cell-rich B-cell lymphoma (H/TCRBCL) samples that were used as controls, mainly due to high expression of PDCD1/PD-1 in H/TCRBCL. EBV(+) cHL tissues could be distinguished from EBV(-) samples by a gene signature characteristic of Th1 and antiviral responses. Samples from cHL patients with favorable outcome overexpressed genes specific for B cells and genes involved in apoptotic pathways. An independent set of 146 cHL samples was analyzed using immunohistochemistry. It showed a significant adverse value in case of high percentage of either TIA-1(+)-reactive cells or topoisomerase-2(+) tumor cells, whereas high numbers of BCL11A(+), FOXP3(+), or CD20(+) reactive cells had a favorable influence. Our results suggest an antitumoral role for B cells in the cHL microenvironment and a stronger stromal influence of the PD1 pathway in H/TCRBCL than cHL. The observation of Th1/ antiviral response in EBV(+) cHL tissues provides a basis for novel treatment strategies. PMID:19096012

Chetaille, Bruno; Bertucci, François; Finetti, Pascal; Esterni, Benjamin; Stamatoullas, Aspasia; Picquenot, Jean Michel; Copin, Marie Christine; Morschhauser, Frank; Casasnovas, Olivier; Petrella, Tony; Molina, Thierry; Vekhoff, Anne; Feugier, Pierre; Bouabdallah, Reda; Birnbaum, Daniel; Olive, Daniel; Xerri, Luc

2008-12-18

55

Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"  

ERIC Educational Resources Information Center

|This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it is impossible and undesirable…

Tan, Sor-Hoon

2011-01-01

56

Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"  

ERIC Educational Resources Information Center

This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it is impossible and undesirable…

Tan, Sor-Hoon

2011-01-01

57

Classical Hairy Cell Leukemia and Its Variant: A 17Year Retrospective Survey in Taiwan Chinese  

Microsoft Academic Search

Background: Classical hairy cell leukemia (HCL-C) and its variant (HCL-V) are rare chronic B-cell lymphoproliferative disorders. Only a few reports in Chinese patients are available. Methods: We retrospectively reviewed 16 patients with HCL-C and HCL-V in Taiwan over a 17-year period. Results: Eight were HCL-C and 8 were HCL-V. All HCL accounted for 0.7% of all adult leukemias. Compared to

Hsiao-Wen Kao; Po Dunn; Ming-Chung Kuo; Lee-Yung Shih; Tung-Liang Lin; Jin-Hou Wu; Tzung-Chih Tang; Hung Chang; Hong-Cheng Wu; Yu-Shin Hung

2011-01-01

58

Primary gastric non-Hodgkin's lymphoma in Chinese patients: clinical characteristics and prognostic factors  

Microsoft Academic Search

BACKGROUND: Optimal management and outcome of primary gastric lymphoma (PGL) have not been well defined in the rituximab era. This study aimed to analyze the clinical characteristics, prognostic factors, and roles of different treatment modalities in Chinese patients with PGL. METHODS: The clinicopathological features of 83 Chinese patients with PGL were retrospectively reviewed. Staging was performed according to the Lugano

JiaJia Huang; WenQi Jiang; RuiHua Xu; HuiQiang Huang; Yue Lv; ZhongJun Xia; XiaoFei Sun; ZhongZhen Guan; TongYu Lin; ZhiMing Li

2010-01-01

59

Common and differential chemokine expression patterns in rs cells of NLP, EBV positive and negative classical Hodgkin lymphomas.  

PubMed

Hodgkin lymphoma (HL) is characterized by a minority of neoplastic cells, the so-called Reed-Sternberg (RS) cells and a vast majority of reactive cells. RS cells produce chemokines that can attract subsets of peripheral blood cells into HL tissues. To gain insight in the chemokines involved in HL, 16 chemokines were selected based on their ability to recruit different subsets of cells. Five HL, 5 non-HL-derived cell lines, 22 HL, 5 non-HL and 3 control tissues were analyzed by reverse transcriptase-polymerase chain reaction (RT-PCR). Products for 13 of these 16 chemokines were detected in 1 or more of the cell lines tested. No or only very faint signals were obtained in HL for CXCL12, CCL7 and CCL8, but CXCL10, CCL5, CCL13, CCL17 and CCL22 were highly or differentially expressed in HL cell lines and tissues. Immunohistochemistry was performed with antibodies reactive with the latter 5 chemokines on paraffin sections of 21 cases of HL. CCL17 and CCL22 had the highest signals in RS cells at gene expression and at protein levels. CCL17 was specific for the classic HL subtypes, whereas CCL22 also had low signals in NLP samples, as well as in some non-HL. CXCL10 was expressed in a large proportion of HL cases with a predominant expression in EBV-positive cases. The results indicate that RS cells produce a complex pattern of chemokines that are involved in the recruitment of reactive cells and contribute to the paradox of an extensive but ineffective host immune response. PMID:12115499

Maggio, Ewerton M; Van Den Berg, Anke; Visser, Lydia; Diepstra, Arjan; Kluiver, Joust; Emmens, Roelke; Poppema, Sibrand

2002-06-10

60

TARC, a CC chemokine, is frequently expressed in classic Hodgkin's lymphoma but not in NLP Hodgkin's lymphoma, T-cell-rich B-cell lymphoma, and most cases of anaplastic large cell lymphoma.  

PubMed

Thymus and activation-regulated chemokine (TARC) has been identified as a lymphocyte-directed CC chemokine that attracts activated T-helper type 2 (Th2) cells in humans. Recent studies showed that the T cells surrounding Reed-Sternberg cells in Hodgkin's lymphomas (HL) are Th2 type. Anaplastic large cell lymphomas (ALCL), T-cell-rich B-cell lymphoma (TCRBCL) can mimic HL in some instances. This study aimed to establish the pattern of TARC expression in these diseases. Immunohistochemical stain using a polyclonal goat anti-human antibody to TARC was performed on 119 cases of confirmed HL; 99 were classical type (43 mixed cellularity, 43 nodular sclerosis, 5 lymphocyte depleted, 4 lymphocyte rich, 4 unclassifiable) and 20 lymphocyte predominant HL. Additional 27 ALCL (9 T-, 18 null-cell phenotype), 16 T-cell and 8 B-cell non-Hodgkin's lymphoma (NHL) were studied. A total of 85.8% of the classical HL, one case of ALCL, and one case of large cell B-cell lymphoma with anaplastic morphology showed positive TARC expression in the tumor cells. The expression was paranuclear and/or diffuse in the cell cytoplasm. The tumor cells in all cases of lymphocyte predominant HL, TCRBCL, null ALCL, and T-NHL did not express TARC. The high frequency of TARC expression in the Reed-Sternberg cells of classical HL may explain the characteristic T-cell infiltrate in this disease. The absence in other types that may be morphologically similar indicates that staining for TARC may aid in differential diagnosis. PMID:11420464

Peh, S C; Kim, L H; Poppema, S

2001-07-01

61

Nodular Lymphocyte Predominant Hodgkin's Lymphoma  

Microsoft Academic Search

Whereas it is estimated that 7800 new cases of Hodgkin’s lymphoma (HL) will be diagnosed in 2006, nodular lymphocyte predominant\\u000a Hodgkin lymphoma (NLPHL) will only account for 3–8% of newly diagnosed HL (1, 2). The majority of the incidence is accounted\\u000a for by the classical Hodgkin lymphoma (cHL) subtypes (nodular sclerosing, lymphocyte rich, lymphocyte depleted, and mixed\\u000a cellularity). There exists

Michelle A. Fanale; Anas Younes

62

Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease.  

PubMed

Recent studies have focused more on Chinese medicine used for the treatment of cerebrovascular disease. The current review covers researches on the pharmacokinetics of Chinese medicine, providing a convenient reference for researchers to increase efficiency of drug discovery, by compiling and discussing the pharmacokinetics of four classical Chinese medicines for therapy of cerebrovascular disease containing: Panax notoginseng, Salvia miltiorrhiza, Ligusticum Chuanxiong and Gardenia. It also helps to eliminate side effect as far as possible from inappropriate Chinese medicine usage. Current integrative and comprehensive review of Chinese medicine for cerebrovascular disease including 1) the absorption of some constituents is limited such as ginsenosides Rg1 and Rb1. It may be affected by gastric juice, first-pass effect, etc. 2) The interactions between Chinese medicine and prescription can occur. Borneol and carbomer would enhance the absorption of R1 and Rg1 in vivo by increasing adjacent cell transport ability. 3) The distribution of active constituents in brain is important for cerebrovascular disease. BBB protects brain from xenobiotic. Intranasal, intra-tympanic administration is a promising alternative to conventional administration to reach brain for ligustrazine. 4) Renal excretion is the uppermost route of these Chinese medicines. But biliary, fecal and urinary excretion are the other major routes. Theoretical and practical aspects are described with pharmacokinetic examples. In the end, this paper also discusses recent development of bio-analysis of Chinese medicine. PMID:23602902

Zeng, Mingfei; Pan, Linmei; Qi, Shunmei; Cao, Yuntai; Zhu, Huaxu; Guo, Liwei; Zhou, Jing

2013-04-18

63

The Transcription Factor PU.1, Necessary for B-Cell Development Is Expressed in Lymphocyte Predominance, But Not Classical Hodgkin's Disease  

PubMed Central

Hodgkin’s disease (HD) is a lymphoproliferative disease of predominantly B-cell origin. However, the reasons for the incomplete development of the B-cell phenotype and lack of immunoglobulin expression in classical HD (cHD) have not been fully explained. We examined the expression of PU.1 in HD, an Ets-family transcription factor, which regulates the expression of immunoglobulin and other genes that are important for B-cell development. Immunohistochemistry for PU.1 was performed on 35 cases of cHD and 15 cases of lymphocyte predominance HD as well as 67 non-Hodgkin’s lymphomas (NHL). Expression of PU.1 was studied by Western blotting in four cHD-derived cell lines and in five NHL cell lines. We also studied the expression of two additional B-cell transcription factors, B-cell-specific activator protein and Oct-2. Our results show a striking lack of PU.1 expression by neoplastic cells in cHD but not in lymphocyte predominance HD. Our study also confirmed that B-cell-specific activator protein but not Oct-2 is not expressed by cHD. Western blotting showed no PU.1 protein expression in the cHD-derived cell lines, with the exception of one cell line of putative monocyte/histiocyte origin. The lack of PU.1 protein expression in cHD likely contributes to the lack of immunoglobulin expression and incomplete B-cell phenotype characteristic of the Reed-Sternberg cells in cHD.

Torlakovic, Emina; Tierens, Anne; Dang, Hien D.; Delabie, Jan

2001-01-01

64

Efficacy of an adapted granzyme B-based anti-CD30 cytolytic fusion protein against PI-9-positive classical Hodgkin lymphoma cells in a murine model  

PubMed Central

Tumors develop when infiltrating immune cells contribute growth stimuli, and cancer cells are selected to survive within such a cytotoxic microenvironment. One possible immune-escape mechanism is the upregulation of PI-9 (Serpin B9) within cancer cells. This serine proteinase inhibitor selectively inactivates apoptosis-inducing granzyme B (GrB) from cytotoxic granules of innate immune cells. We demonstrate that most classical Hodgkin lymphoma (cHL)-derived cell lines express PI-9, which protects them against the GrB attack and thereby renders them resistant against GrB-based immunotherapeutics. To circumvent this disadvantage, we developed PI-9-insensitive human GrB mutants as fusion proteins to target the Hodgkin-selective receptor CD30. In contrast to the wild-type GrB, a R201K point-mutated GrB construct most efficiently killed PI-9-positive and -negative cHL cells. This was tested in vitro and also in vivo whereby a novel optical imaging-based tumor model with HL cell line L428 was applied. Therefore, this variant, as part of the next generation immunotherapeutics, also named cytolytic fusion proteins showing reduced immunogenicity, is a promising molecule for (targeted) therapy of patients with relapsing malignancies, such as cHL, and possibly other PI-9-positive malignancies, such as breast or lung carcinoma.

Schiffer, S; Hansen, H P; Hehmann-Titt, G; Huhn, M; Fischer, R; Barth, S; Thepen, T

2013-01-01

65

Hodgkin's Lymphoma (Hodgkin's Disease)  

MedlinePLUS

... used to treat Hodgkin's lymphoma. Side effects of chemotherapy depend on the specific drugs you're given. Common side effects include nausea and hair loss. Serious long-term complications can occur, such as heart damage, lung damage, ...

66

Multilayer Anchor Alignment in ACE Parallel Corpora of Chinese Tea Classics  

Microsoft Academic Search

Chinese tea literature has not made its appearance in the existing corpora. Bilingual corpus of ancient Chinese and English (AC-E) also wait to be extended for purposes such as CAT and designing educational software for Confucius Institutes all over the world. This paper aims at such a corpus by demonstrating multilayer anchor-points in improving the alignment accuracy in a bilingual

Jiang Yi; Jiang Xin; Wang Dapeng

2009-01-01

67

Inclusive strategies for restraining aggression—lessons from classical Chinese culture  

Microsoft Academic Search

An extensive body of Chinese philosophical thought suggests a redefinition of international security in terms of a non?threatening formulation of Comprehensive Security. In one culture viewed as particularly ‘strategic’, i.e. Chinese culture, we find strong traditions of inclusive, non?aggressive forms of security. Mo Tzu and the school of Mohism (5th?3rd centuries BC) developed a rigorous body of thought and practice

R. James Ferguson

1998-01-01

68

Tumor Necrosis Factor-? Induced Protein 8 Polymorphism and Risk of Non-Hodgkin's Lymphoma in a Chinese Population: A Case-Control Study  

PubMed Central

Background Non-Hodgkin’s lymphoma (NHL) has been reported to be associated with autoimmune and pro-inflammatory response, and genetic polymorphisms of candidate genes involved in autoimmune and pro-inflammatory response may influence the susceptibility to NHL. To evaluate the role of such genetic variations in risk of NHL, we conducted a case-control study of 514 NHL patients and 557 cancer-free controls in a Chinese population. Method We used the Taqman assay to genotype six potentially functional single nucleotide polymorphisms (SNPs) in six previously reported inflammation and immune-related genes (TNF rs1799964T>C, LTA rs1800683G>A, IL-10 rs1800872T>G, LEP rs2167270G>A, LEPR rs1327118C>G, TNFAIP8 rs1045241C>T). Logistic regression models were used to estimate odds ratios (ORs) and 95% confidence intervals (95% CI). Results We observed a significantly increased risk of NHL associated with the TNFAIP8 rs1045241C>T polymorphism (adjusted OR?=?3.03; 95% CI?=?1.68–5.45 for TT vs. CC and adjusted OR?=?2.03; 95% CI?=?1.53–2.69 for CT/TT vs. CC). The risk associated with the T allele was more evident in subgroups of 40–60 year-old, non-smokers or light-smokers (less than 25 pack-years), and subjects with normal weight or overweight. Risk for both B and T cell non-Hodgkin’s lymphoma was elevated for CT/TT genotypes (adjusted OR?=?1.95, 95% CI?=?1.41–2.70 for B cell NHL and adjusted OR?=?2.22, 95% CI?=?1.49–3.30 for T cell NHL), particularly for DLBCL (adjusted OR?=?2.01, 95%CI?=?1.41–2.85) and FL (adjusted OR?=?2.53, 95% CI?=?1.17–5.45). These risks were not observed for variant genotypes of other five SNPs compared with their common homozygous genotypes. Conclusions The polymorphism of TNFAIP8 rs1045241C>T may contribute to NHL susceptibility in a Chinese population. Further large-scale and well-designed studies are needed to confirm these results.

Zhang, Yan; Wang, Meng-Yun; He, Jing; Wang, Jiu-Cun; Yang, Ya-Jun; Jin, Li; Chen, Zhi-Yu; Ma, Xue-Jun; Sun, Meng-Hong; Xia, Kai-Qin; Hong, Xiao-Nan; Wei, Qing-Yi; Zhou, Xiao-Yan

2012-01-01

69

Primary gastric Hodgkin's lymphoma  

PubMed Central

Background Primary Hodgkin's disease of the stomach is an extremely rare entity. Nearly all cases of primary gastric lymphoma are of the non-Hodgkin's variety. Diagnoses in such cases are difficult due to considerable histological similarities between the 2 disease entities. Case presentation We report the case of a 77 year old lady with a 1 year history of weight loss and poor appetite. Physical examination was unremarkable. Subsequent multiple upper GI endoscopies revealed a large malignant looking ulcer which was deemed to be histologically benign. Following CT imaging the patient underwent a radical gastrectomy. Postoperatively histology and immunohistochemistry failed to confirm a diagnosis. As such a second opinion was sought. Employing an extended array of immunohistological staining a diagnosis of 'Classical Hodgkin's' disease of the stomach was achieved. Conclusion Our case illustrates the significant difficulties in achieving a rare diagnosis of primary Hodgkin's lymphoma of the stomach. The non-specific nature of symptoms and a lack of histological features make a preoperative diagnosis extremely difficult. While immunohistochemistry is widely employed in aiding the evaluation of such cases, one should be wary of the considerable overlap in differentiating between Hodgkin's and non-Hodgkin's disease entities using this technique.

Hossain, Fahad S; Koak, Yashwant; Khan, Farrukh H

2007-01-01

70

Classical Hodgkin's lymphoma in adults: guidelines of the Italian Society of Hematology, the Italian Society of Experimental Hematology, and the Italian Group for Bone Marrow Transplantation on initial work-up, management, and follow-up  

PubMed Central

The Italian Society of Hematology (SIE), the Italian Society of Experimental Haematology (SIES) and the Italian Group for Bone Marrow Transplantation (GITMO) commissioned a project to develop practice guidelines for the initial work-up, therapy and follow-up of classical Hodgkin’s lymphoma. Key questions to the clinical evaluation and treatment of this disease were formulated by an Advisory Committee, discussed and approved by an Expert Panel (EP) composed of senior hematologists and one radiotherapist. After a comprehensive and systematic literature review, the EP recommendations were graded according to their supporting evidence. An explicit approach to consensus methodologies was used for evidence interpretation and for producing recommendations in the absence of a strong evidence. The EP decided that the target domain of the guidelines should include only classical Hodgkin’s lymphoma, as defined by the WHO classification, and exclude lymphocyte predominant histology. Distinct recommendations were produced for initial work-up, first-line therapy of early and advanced stage disease, monitoring procedures and salvage therapy, including hemopoietic stem cell transplant. Separate recommendations were formulated for elderly patients. Pre-treatment volumetric CT scan of the neck, thorax, abdomen, and pelvis is mandatory, while FDG-PET is recommended. As to the therapy of early stage disease, a combined modality approach is still recommended with ABVD followed by involved-field radiotherapy; the number of courses of ABVD will depend on the patient risk category (favorable or unfavorable). Full-term chemotherapy with ABVD is recommended in advanced stage disease; adjuvant radiotherapy in patients without initial bulk who achieved a complete remission is not recommended. In the elderly, chemotherapy regimens more intensive than ABVD are not recommended. Early evaluation of response with FDG-PET scan is suggested. Relapsed or refractory patients should receive high-dose chemotherapy and autologous hemopoietic stem cells transplant. Allogeneic transplant is recommended in patients relapsing after autologous transplant. All fertile patients should be informed of the possible effects of therapy on gonadal function and fertility preservation measures should be taken before the initiation of therapy.

Brusamolino, Ercole; Bacigalupo, Andrea; Barosi, Giovanni; Biti, Giampaolo; Gobbi, Paolo G.; Levis, Alessandro; Marchetti, Monia; Santoro, Armando; Zinzani, Pier Luigi; Tura, Sante

2009-01-01

71

Psychometric properties of the Mastery Scale-Chinese version: Applying classical test theory and Rasch analysis.  

PubMed

Abstract Aims: This study examines the reliability and validity of the Mastery Scale-Chinese version (MS-C) when applied to three groups diagnosed with major depression, schizophrenia, or HIV/AIDS. Methods: The individuals participating in the study were recruited from outpatient units of a medical center and a municipal hospital in northern Taiwan. The study sample (n = 2009) included 237 patients with depressive disorders, 160 with schizophrenia, and 1612 with HIV/AIDS. The reliability and construct validity of the MS-C was evaluated by confirmatory factor analysis (CFA) and Rasch analysis. Results: The results of the CFA showed that the MS-C has adequate construct validity with all indices meeting the criteria, except for chi-square values. The Rasch analysis supported the four-point rating scale structure and a unidimensional construct of the MS-C. The DIF analysis showed that all items demonstrated stable measurement properties among the different diagnosis groups (major depression, schizophrenia, HIV/AIDS). Conclusion: This study found that MS-C has acceptable psychometric qualities in terms of reliability, construct validity, rating scale performance, and item characteristics when applied to patients with depression, schizophrenia, and HIV/AIDS in Taiwan. PMID:24066856

Chen, Yun-Ling; Hsiung, Ping-Chuan; Chung, Lyinn; Chen, Shing-Chia; Pan, Ay-Woan

2013-09-26

72

Molecular characterization of seven Chinese isolates of infectious bursal disease virus: classical, very virulent, and variant strains.  

PubMed

Seven infectious bursal disease virus (IBDV) strains isolated from China have been characterized in this study, including a classical strain CJ801, an attenuated strain GZ911, a variant strain GZ902, and four very virulent strains G9201, G9302, F9502, and HK46. With the use of reverse transcription-polymerase chain reaction, the full-length VP2 genes were amplified and the hypervariable regions were sequenced. Protein sequences of the hypervariable region (a.a. 143-382) of the field isolates confirmed their identities. CJ801 has the highest identity to the classical strains STC and 52/70. GZ902 has the highest identity to the American variant strains A, E, and GLS, and they share unique amino acid residue at positions 249K and 254S, which are not present in standard serotype 1 strains. Attenuated strain GZ911, like other cell culture-adapted strains, has substitutions at positions 279(D to N) and 284 (A to T) as well as in the serine-rich heptapeptide region. Hence, these substitutions may take an important role in the reduced virulence of these strains. The four very virulent strains have the highest identity to the European very virulent strain UK661 and Japanese strain OKYM. These strains share unique amino acid residues at positions 222A, 256I, and 294I, which are not present in other less virulent strains. The very virulent strains isolated in Guangdong (G9201, G9303) and Fujian (F9502) Provinces have one to five amino acid substitutions at the two hydrophilic domains of VP2 comparing with UK661 and OKYM, indicating that new very virulent strains are evolving. Phylogenetic analysis suggests that Chinese very virulent IBDVs and European very virulent strains are derived from similar origin. PMID:9645325

Cao, Y C; Yeung, W S; Law, M; Bi, Y Z; Leung, F C; Lim, B L

73

Hodgkin Lymphoma  

MedlinePLUS

The Leukemia & Lymphoma Society (LLS) is the world's largest voluntary health agency dedicated to blood cancer. The LLS mission: Cure leukemia, lymphoma, Hodgkin's disease and myeloma, and improve the quality ...

74

Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma (HL) is a curable malignancy which shows a bimodal curve in incidence in economically developed countries; there is a putative association with Epstein-Barr virus. The WHO 2008 classification schema recognises two histological types of HL: the nodular lymphocyte predominant and the "classic" HL. The latter encompasses four entities: nodular sclerosis, mixed cellularity, lymphocyte depletion, and lymphocyte-rich. Most patients with HL present with asymptomatic superficial lymphadenopathy. The commonest sites of disease are the cervical, supraclavicular and mediastinal lymph nodes, while sub-diaphragmatic presentations and bone marrow and hepatic involvement are less common. Splenic involvement is usually concomitant with hepatic disease and systemic symptoms; extranodal presentations are quite rare. Systemic symptoms are present in ?35% of cases. The stage of disease is defined according to the Ann Arbor staging system or its Cotswolds variant, and staging work-up includes physical examination, chest X-rays, chest and abdominal CT scan, and bone marrow biopsy. (18)FDG-PET ((18)fluordeoxyglucose positron emission tomography) plays a central role in staging, response assessment and prognosis definition. Classic HL usually spreads by contiguity within the lymphatic tissue network, with a late extension to adjacent and distant viscera. Mortality from HL has been progressively decreasing, as confirmed by the most recent 5-year survival figure of 81%. The list of putative prognostic factors in HL has been increasing, but most factors still require prospective validation. Some of these variables are used to stratify early-stage disease into "favourable" and "unfavourable" categories, with "unfavourable early-stage" being intermediate between "favourable early-stage" and "advanced-stage". ABVD (adriamycin(doxorubicin), bleomycin, vinblastine, dacarbazine) combination chemotherapy followed by involved-field irradiation is the standard treatment for patients with early-stage HL, with a 5-year OS >95%. Several trials assessing less intensive approaches for patients with favourable early-stage HL are ongoing. More intensified combinations, such as the BEACOPP (bleomycin, etoposide, adriamycin, cyclophosphamide, vincristine (Oncovin), procarbazine, prednisone) regimen, are being investigated, usually in patients with unfavourable early-stage HL and interim PET+. ABVD is the standard chemotherapy treatment also for patients with advanced disease. Although some evidence suggests that more intensive combinations provide better disease control, the inevitable increased risk of relevant late toxicity worries investigators. Consequently, there has been a shift towards investigating the innovative strategy of a more aggressive schedule for patients with (18)FDG-PET positive results after the first 2 courses of ABVD. High-dose chemotherapy supported by ASCT (autologous stem cell transplantation) is considered the standard of care in patients with HL which has relapsed after, or is refractory to conventional chemoradiotherapy, while allogeneic transplant is a suitable tool for patients with chemorefractory disease and patients failed after ASCT. PMID:22867814

Gobbi, Paolo G; Ferreri, Andrés J M; Ponzoni, Maurilio; Levis, Alessandro

2012-08-04

75

Hodgkin's Disease  

Microsoft Academic Search

Two hundred and fifty cases of histologically proven Hodgkin's disease have been reviewed. These cases were classified according to the Rye Conference histological classification (Lukes et al., 1966a) and according to the Cross classification (Cross, 1969). Overall, both classifications were reasonably effective in predicting prognosis but that of Cross with its seven sub-groups proved more difficult to use than the

K A Newton; D H Mackenzie; Margaret F Spittle; Anna Mikolajczuk

1973-01-01

76

Polymorphisms in the promoter region of the CASP8 gene are not associated with non-Hodgkin’s lymphoma in Chinese patients  

Microsoft Academic Search

Caspase-8 (CASP8) involved in apoptosis plays an important role in mediating the normal regulation of cell proliferation,\\u000a differentiation, inflammation, and homeostasis of multicellular organisms. Genetic polymorphisms, rs3834129 (?\\/CTTACT) and\\u000a rs3769821 (T\\/C), in the promoter region of different CASP8 transcripts, were reported to be associated with genetic susceptibility of multiple cancers and non-Hodgkin’s lymphoma (NHL),\\u000a respectively. To investigate whether these two

Mei-Sheng Xiao; Deng-Feng Zhang; Yun Zeng; Yun-Feng Cheng; Yong-Gang Yao

77

Hodgkin lymphoma  

PubMed Central

Hodgkin lymphoma (HL), a B cell–derived cancer, is one of the most common lymphomas. In HL, the tumor cells — Hodgkin and Reed-Sternberg (HRS) cells — are usually very rare in the tissue. Although HRS cells are derived from mature B cells, they have largely lost their B cell phenotype and show a very unusual co-expression of markers of various hematopoietic cell types. HRS cells show deregulated activation of multiple signaling pathways and transcription factors. The activation of these pathways and factors is partly mediated through interactions of HRS cells with various other types of cells in the microenvironment, but also through genetic lesions. The transforming events involved in the pathogenesis of HL are only partly understood, but mutations affecting the NF-?B and JAK/STAT pathways are frequent. The dependency of HRS cells on microenvironmental interactions and deregulated signaling pathways may offer novel strategies for targeted therapies.

Kuppers, Ralf; Engert, Andreas; Hansmann, Martin-Leo

2012-01-01

78

CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin's lymphoma  

PubMed Central

Background Advances in the understanding of Hodgkin's lymphoma (HL) show various functions of infiltrating immune cells and cytokines in relation to clinical outcomes. The expression of CD163 and c-Met has been suggested to have a role in lymphoid malignancy. Thus, we evaluated the expressions of CD163, c-Met, and serum free light chain (sFLC) in relation to the clinicopathological features of patients with advanced classical HL (cHL). Methods We assessed the expression of CD163 and c-Met in 34 patients with cHL through immunohistochemistry on the lymph node biopsy sections and the levels of pretreatment sFLC were estimated using ELISA. Results High CD163 expression correlated with increased age, B symptoms, International Prognostic Score (IPS) ?3, mixed cellularity subtype, and low response to treatment. Further, high c-Met expression correlated with increased age at diagnosis, leukocytosis, B symptoms, and lower chance to achieve complete remission. The sFLC levels correlated with increased age at diagnosis, lymphopenia, IPS ?3, B symptoms, and lower complete remission rates. Conclusion In advanced cHL, increased expression of CD163 and c-Met showed a significant association with adverse prognostic parameters and poor response to treatment. Pretreatment high sFLC level also correlated with poor risk factors, suggesting its use as a candidate prognostic marker. A comprehensive approach for prognostic markers might represent a step towards developing a tailored therapeutic approach for HL.

Bedewy, Magdy; El-Maghraby, Shereen

2013-01-01

79

Lymphocyte predominant Hodgkin’s disease  

Microsoft Academic Search

Lymphocyte predominant Hodgkin’s disease (LPHD) is a rare type of B-cell lymphoma with unique pathologic and clinical features\\u000a that distinguish it from other types of Hodgkin’s disease. Patients with LPHD tend to be younger males who present with indolent\\u000a and asymptomatic lymphadenopathy limited to peripheral lymph nodes. The immunophenotype of the malignant lymphocytic and\\/or\\u000a histiocytic cells (CD20+, CD15-, CD30-) forms

Bradley C. Ekstrand; Sandra J. Horning

2002-01-01

80

Chinese Mathematics  

NSDL National Science Digital Library

The School of Mathematics and Statistics at the University of St. Andrews Scotland offers this website on the history of Chinese Mathematics. Key features highlighted in the overview include: a discussion of the Chinese version of Pythagoras's theorem, a famous Chinese mathematics book commonly known as the Nine Chapters on the Mathematical Art, and the work of several Chinese mathematicians. Visitors to the website can also browse a chronological listing of several Chinese mathematicians and read about their careers. Other features of the website include a section summarizing each chapter from the Nine Chapters on the Mathematical Art, a section highlighting ten other mathematical classics, a review of the Chinese numeral system, and a collection of Chinese problems, which are extracted from various articles in their archive.

81

An improved association-mining research for exploring Chinese herbal property theory: based on data of the Shennong's Classic of Materia Medica.  

PubMed

Knowledge Discovery in Databases is gaining attention and raising new hopes for traditional Chinese medicine (TCM) researchers. It is a useful tool in understanding and deciphering TCM theories. Aiming for a better understanding of Chinese herbal property theory (CHPT), this paper performed an improved association rule learning to analyze semistructured text in the book entitled Shennong's Classic of Materia Medica. The text was firstly annotated and transformed to well-structured multidimensional data. Subsequently, an Apriori algorithm was employed for producing association rules after the sensitivity analysis of parameters. From the confirmed 120 resulting rules that described the intrinsic relationships between herbal property (qi, flavor and their combinations) and herbal efficacy, two novel fundamental principles underlying CHPT were acquired and further elucidated: (1) the many-to-one mapping of herbal efficacy to herbal property; (2) the nonrandom overlap between the related efficacy of qi and flavor. This work provided an innovative knowledge about CHPT, which would be helpful for its modern research. PMID:24063783

Jin, Rui; Lin, Zhi-Jian; Xue, Chun-Miao; Zhang, Bing

2013-09-01

82

Non-Hodgkin's lymphoma  

MedlinePLUS

Lymphoma - non-Hodgkin's; Lymphocytic lymphoma; Histiocytic lymphoma; Lymphoblastic lymphoma; Cancer - non-Hodgkin's lymphoma ... in lymph tissues. They help prevent infections. Most lymphomas start in a type of white blood cells ...

83

The Interrelationship of Chinese Music and Poetry  

Microsoft Academic Search

Unlike its Western counterpart, Chinese poetry has a more important role in Chinese literary history, especially classical Chinese poetry, which dominated literature as well as art throughout history. However, when making an intratextual analysis of this genre, we find the generic roots of classical Chinese poetry have stemmed from music. The studies of the dichotomous nature of Chinese poetry and

YANPING WANG

84

Primary pulmonary Hodgkin's lymphoma  

PubMed Central

A 21-year-old man presented to hospital with a two-month history of productive cough with no other symptoms. Radiology revealed a cavitating lesion in the left upper lobe for which a variety of diagnoses were considered. A biopsy revealed primary pulmonary Hodgkin’s lymphoma. Primary pulmonary Hodgkin’s lymphoma is an uncommon initial presentation; lung lesions usually occur later in the course of the disease. Following diagnosis, the patient began chemotherapy and full remission was achieved.

Lluch-Garcia, R; Briones-Gomez, A; Castellano, E Monzo; Sanchez-Toril, F; Lopez, A; Brotons, B

2010-01-01

85

Hodgkin lymphoma in Tyrol—a population-based study  

Microsoft Academic Search

We aimed to analyze the epidemiology, clinical characteristics, and outcome of patients with Hodgkin lymphoma (HL) diagnosed\\u000a in Tyrol. All patients with newly diagnosed HL between 1993 and 2005 were included in this study. Among the 158 cases included,\\u000a nodular lymphocytic predominant HL (nodular paragranuloma) was identified in ten cases (6%) whereas the majority of patients\\u000a had classical Hodgkin lymphoma.

Dominic Fong; Michael Steurer; Richard Greil; Eberhard Gunsilius; Gilbert Spizzo; Guenther Gastl; Alexandar Tzankov

2009-01-01

86

Thomas Hodgkin: Social activist  

Microsoft Academic Search

Thomas Hodgkin's discovery of a lymphgl and disorder is merely one event in a life of unusually varied public activities in the social reform and humanitarian movements of the mid-19th century. He wrote pamphlets on medical care for the working-class poor, public health, housing, sanitation, and the relief of cold, hunger, and unemployment. Hodgkin wrote about the problems arising from

Louis Rosenfeld

2000-01-01

87

Nodular Lymphocyte Predominant Hodgkin's Lymphoma Presenting as Severe Hypercalcaemia: A Case Report  

PubMed Central

Nodular lymphocyte predominant Hodgkin’s lymphoma (NLPHL) is a recently described type of Hodgkin’s lymphoma (HL) and accounts for 5–6% of all the cases of HL. Here we report the case of an elderly man who presented to Sultan Qaboos University Hospital, Oman, with severe hypercalcemia, and was diagnosed to have stage IV NLPHL. Although the incidence of hypercalcemia is estimated to be between 1–5% in classical HL, to our knowledge this is the first report of NLPHL presenting with severe hypercalcemia. The patient responded to the anti-CD20 monoclonal antibody, Rituximab, and has been in clinical remission for more than 3 years.

Burney, Ikram A; Nirmala, V; Al-Moundhri, Mansour S; Woodhouse, Nicholas J

2007-01-01

88

Immunophenotyping of Hodgkin's disease--an aid to its classification.  

PubMed

Based on morphological, phenotypic, genotypic and clinical findings, Hodgkin's disease has recently been classified into two subtypes: Nodular lymphocyte predominant and classical Hodgkin's disease. Forty-two cases of Hodgkin's disease were subjected to detailed morphological assessment and immunophenotyping. The commonest subtype was Nodular Sclerosis seen in 27 cases. The panel of antibodies used was CD 15, CD 30, CD 3, CD 20, CD 45 and Epithelial Membrane Antigen. Immunophenotyping was done by Streptavidin Biotin Peroxidase complex technique. CD 30 was expressed in 86% and CD 15 in 76% cases. Immunophenotype helped reclassify two cases, according to the WHO classification scheme. Although morphology remains the gold standard in the diagnosis of Hodgkin's disease, immunophenotype is a useful adjunct in differentiating prognostically distinct subtypes. PMID:16933709

Kalyan, Koti; Basu, Debdatta; Soundararaghavan, Jayanthi

2006-04-01

89

Dorothy Crowfoot Hodgkin  

NASA Astrophysics Data System (ADS)

Born in 1910 in Cairo, Egypt, Dorothy Crowfoot Hodgkin would later be known as the third woman in history to win the Nobel Prize in Chemistry for her research on the structure of vitamin B-12. Her X-ray crystallography work also included discovering the molecular structure of penicillin and insulin. Dr. Hodgkin's work has aided in determining the structures of molecules for others to expand the technology necessary for today's medicine.

Montalvo, Jessica

2009-10-01

90

PET imaging in pediatric Hodgkin’s lymphoma  

Microsoft Academic Search

Advances in diagnostic imaging technology, especially functional imaging modalities like positron emission tomography (PET), have significantly influenced the staging and treatment approaches used for pediatric Hodgkin’s lymphoma. Today, the majority of children and adolescents diagnosed with Hodgkin’s lymphoma will be cured following treatment with non-cross-resistant combination chemotherapy alone or in combination with low-dose, involved-field radiation. This success produced a greater

Melissa M. Hudson; Matthew J. Krasin; Sue C. Kaste

2004-01-01

91

Epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma  

Microsoft Academic Search

This review considers in detail the descriptive and aetiological epidemiology of Hodgkin's disease and non-Hodgkin's lymphoma (NHL), with attention to histological subcategories when the literature allows. The aetiology of Hodgkin's disease remains only partially understood. There is evidence that Epstein-Barr virus (EBV) may be involved in the causation of some cases, and clinical immune deficiency is a risk factor for

A. J. Swerdlow

2003-01-01

92

Determination of AntiTumor Constitute Mollugin from Traditional Chinese Medicine Rubia cordifolia: Comparative Study of Classical and Microwave Extraction Techniques  

Microsoft Academic Search

Rubia cordifolia is a common traditional Chinese medicine (TCM) used for centuries for the treatment of cough, inflammation of the joints, uterine hemorrhage, and uteritis. Mollugin is a major active component present in R. cordifolia and recognized as a potential anti-tumor compound. In this work, a microwave-assisted extraction (MAE) method has been developed for extracting mollugin from R. cordifolia. Several

Wenyan Ma; Yanbin Lu; Xiaojing Dai; Rui Liu; Ruilin Hu; Yuanjiang Pan

2009-01-01

93

Treating Nodular Lymphocyte Predominant Hodgkin Disease (NLPHD)  

MedlinePLUS

... for Hodgkin disease Radiation therapy for Hodgkin disease Monoclonal antibodies for Hodgkin disease High-dose chemotherapy and stem ... prefer others. Another option is to give the monoclonal antibody rituximab (Rituxan), with or without chemotherapy (and sometimes ...

94

[Nodular lymphocyte-predominant Hodgkin's lymphoma and differential diagnoses].  

PubMed

Nodular lymphocyte-predominant Hodgkin's lymphoma (NLPHL) is a rare subtype of Hodgkin's lymphoma. The histological patterns of NLPHL variants are characterized by different localizations of the tumor cells, intranodular and perinodular and by the varying composition of the microenvironment. T-cell/histiocyte-rich B-cell lymphoma may be the result of an aggressive transformation of NLPHL. Classical lymphocyte-rich Hodgkin's lymphoma can usually be clearly distinguished from NLPHL by the immunophenotype of the tumor cells. Further differential diagnoses include follicular lymphoma and the follicular variant of peripheral T-cell lymphoma. Angioimmunoblastic T-cell lymphoma with CD20-positive blasts represents a differential diagnosis to the diffuse variants of NLPHL. PMID:23494280

Hartmann, S; Cogliatti, S; Hansmann, M-L

2013-05-01

95

HODGKIN'S DISEASE, a Clinical-Pathological Review of 150 Cases  

PubMed Central

One hundred and fifty cases of Hodgkin's disease were analyzed in an effort to detect significant clinical-pathological correlations and to elucidate any possible factors of prognostic or etiological importance. A relatively long survival for patients with Hodgkin's paragranuloma was not noted in this series. Instead the survival rate among them was closely parallel to that of patients with classical granuloma. Hodgkin's sarcoma is a more malignant disease with a patient survival rate not more than half that of patients with the granuloma variety. It is not necessarily a disease of older age groups. Great caution must be exercised to avoid including non-Hodgkin's disease tumors under the heading of Hodgkin's sarcoma or paragranuloma. The series reported corresponds with many other reported series of Hodgkin's disease as regards greater incidence in males and longer survival in females. In this series the cases in patients under the age of 15 were all in males. The predominance of initial enlargement of the cervical nodes was again noted in this series, as was the high proportion of negative reaction to tuberculin tests. The incidence of tuberculous lesions in patients who died of Hodgkin's disease was only slightly greater than in those who died of other lymphoma. Site of origin of the disease apparently affects survival time. There was statistical evidence that gonadal activity might influence the equilibrium of the disease. Lymph node bacteriological cultures were not remarkable. Brucella organisms were absent. Fertile egg passages for detecting possible viral agents revealed increased egg mortality and cutaneous sensitivity reactions to the harvested amniotic fluid.

Bostick, Warren L.

1949-01-01

96

Lymphocyte-Predominant Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Lymphocyte-predominant Hodgkin lymphoma (LPHL) was first described in 1944 by Jackson and Parker as nodular paragranuloma\\u000a [1]. Other synonyms used were lymphocytic predominant Hodgkin disease, lymphocytic and histiocytic (L&H) predominant Hodgkindisease,\\u000a nodular lymphocyte-predominant Hodgkin disease, and nodular LPHL [2–5]. This term has become the one that is currently being\\u000a used. LPHL represents 5% of all HL cases and is a

Andreas Engert; Anas Younes

97

Staging Non-Hodgkin Lymphoma  

Microsoft Academic Search

ABSTRACT Non-Hodgkin Lymphomas,are always treatable and frequently curable malignan- cies. However, choosing the most appropriate therapy requires accurate diagnosis and a carefulstagingevaluation.Newpatientswithnon-HodgkinLymphomashouldhavetheirtumors classified using the World Health Organization classification. The specific choice of therapy is dependent,on a careful staging evaluation. Patients with non-Hodgkin Lymphoma,are assigned an anatomic stage using the Ann Arbor system. However, patients should also be classified using

James O. Armitage

2010-01-01

98

Somatic Mutations of the CD95 Gene in Hodgkin and Reed-Sternberg Cells1  

Microsoft Academic Search

Hodgkin and Reed-Sternberg (H\\/RS) cells in classical Hodgkin's dis- ease (cHD) are thought to be derived from preapoptotic germinal center B cells. However, little is known about the transforming events rescuing the precursor of the H\\/RS cells from apoptosis. Given the importance of CD95 (Apo-1\\/Fas)-mediated apoptosis for negative selection within the germinal center, single micromanipulated H\\/RS cells from 10 cases

Markus Muschen; Daniel Re; Andreas Brauninger; Jurgen Wolf; Martin-Leo Hansmann; Volker Diehl; Ralf Kuppers; Klaus Rajewsky

2000-01-01

99

Hodgkin's lymphoma: the pathologist's viewpoint  

PubMed Central

Despite its well known histological and clinical features, Hodgkin's lymphoma (HL) has recently been the object of intense research activity, leading to a better understanding of its phenotype, molecular characteristics, histogenesis, and possible mechanisms of lymphomagenesis. There is complete consensus on the B cell derivation of the tumour in most cases, and on the relevance of Epstein-Barr virus infection and defective cytokinesis in at least a proportion of patients. The REAL/WHO classification recognises a basic distinction between lymphocyte predominance HL (LP-HL) and classic HL (CHL), reflecting the differences in clinical presentation and behaviour, morphology, phenotype, and molecular features. CHL has been classified into four subtypes: lymphocyte rich, nodular sclerosing, with mixed cellularity, and lymphocyte depleted. The borders between CHL and anaplastic large cell lymphoma have become sharper, whereas those between LP-HL and T cell rich B cell lymphoma remain ill defined. Treatments adjusted to the pathobiological characteristics of the tumour in at risk patients have been proposed and are on the way to being applied.

Pileri, S A; Ascani, S; Leoncini, L; Sabattini, E; Zinzani, P L; Piccaluga, P P; Pileri, A; Giunti, M; Falini, B; Bolis, G B; Stein, H

2002-01-01

100

Classical Mechanics  

NSDL National Science Digital Library

This textbook, a standard in advanced classical mechanics, covers the breadth of the subject. This latest edition contains sections in contemporary classical mechanics, applications, and computer and mathematical techniques for solving systems.

Goldstein, Herbert; Poole Jr., Charles P.; Safko, John L.

2004-06-17

101

Hodgkin-Huxley Axon  

PubMed Central

Repetitive response patterns resembling those of tonic receptors were obtained by increasing the potassium system time constant in the Hodgkin-Huxley (H-H) equations. The increase in time constant varied with membrane potential. Calculated spike frequencies varied linearly with the magnitude of the constant current stimulus; in addition, minimum frequencies were greatly reduced, and the frequency range increased. Modification of the maximum ionic conductances, membrane capacitance, and rate constant voltage dependence was found to vary the minimum frequency, current at that frequency, slope, and over-all modulation of the modified responses.

Shapiro, B. I.; Lenherr, F. K.

1972-01-01

102

From Tewksbury to Du Fu: Exercises toward Introducing Graduate Students to the Study of Chinese Literature.  

ERIC Educational Resources Information Center

|Discusses a series of exercises designed to convince advanced Chinese language students that the careful study of classical Chinese literature is both a necessary and enjoyable part of their scholarly training. Several excerpts from Chinese literature are given. (PJM)|

Nienhauser, William H., Jr.

1980-01-01

103

Hodgkin-Huxley Model  

NSDL National Science Digital Library

The Hodgkin Huxley Model shows the neuron voltage within the cell of a squid giant axon. This voltage is due to the currents flowing into the neuron and charging the capacitance of the lipid bilayer cell wall. Currents into the neuron are based on sodium and potassium ions flowing into and out of the neuron based on voltage-gates channels in the cell wall. The flow of these ions is determined by dimensionless variables that represent the probability a potassium, sodium activation, or sodium inactivation gate is opened, respectively. This model allows these parameters to be set by the user. The Hodgkin Huxley Model was developed using the Easy Java Simulations (EJS) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the jar file will run the program if Java is installed. You can modify this simulation if you have EJS installed by right-clicking within the map and selecting "Open Ejs Model" from the pop-up menu item.

Thomson, Colin F.

2012-09-07

104

Treatment of Advanced Stage Hodgkin’s Disease  

Microsoft Academic Search

Hodgkin’s disease remains one of the few malignant diseases which can be cured by modern chemotherapy in most cases even in advanced stages. Adriamycin-containing chemotherapy regimens are considered as the standard therapy which induce long-term remission in about 60–70% of patients. The ABVD scheme, developed by Bonadonna and colleagues in Milan, has a favorable toxicity profile and causes less myelotoxicity,

H. Tesch; M. Sieber; V. Diehl

2001-01-01

105

A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2013-07-15

106

Classics Online.  

ERIC Educational Resources Information Center

|Appraises several databases devoted to classical literature. Thesaurus Linguae Graecae (TLG) contains the entire extant corpus of ancient Greek literature, including works on lexicography and historiography, extending into the 15th century. Other works awaiting completion are the Database of Classical Bibliography and a CD-ROM pictorial…

Clayman, Dee L.

1995-01-01

107

Molecular Pathogenesis of Hodgkin Lymphoma  

Microsoft Academic Search

Hodgkin lymphoma (HL) is a distinctive lymphoma subtype that accounts for approximately 30% of all lymphomas in the Western\\u000a world and approximately 5% in Japan. HL is characterized by the giant multinucleated tumor cells called Hodgkin\\/Reed-Sternberg\\u000a (H\\/RS) cells, but the cellular origin had long been unknown. Recent investigations have clarified that H\\/RS cells have a clonally\\u000a rearranged immunoglobulin gene in

Momoko Nishikori; Takashi Uchiyama

2006-01-01

108

Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma

2013-04-05

109

Chinese Political Communication: Roots in Tradition and Impacts on Contemporary Chinese Thought and Culture  

Microsoft Academic Search

This study offers a review of traditional Chinese political thought and an array of rhetorical practices in ancient China. It examines how the rhetorical features of contemporary Chinese political discourse resemble those of classical Chinese rhetoric with emphasis on worshiping of the ruler, moral\\/ethical appeals, ritualistic practices, and the employment of metaphors. The author argues that similar rhetorical forms have

Xing Lu

2002-01-01

110

[Jejunal mucormycosis in a patient with Hodgkin's lymphoma].  

PubMed

We report a case of intestinal mucormycosis in a 46-year-old male diagnosed with classical Hodgkin's disease, IV-B stage. During the first phase of chemotherapy he had a massive digestive bleeding event secondary to a jejunal ulcer, and zygomicosis mucor-type was diagnosed by endoscopic biopsy. The patient was treated with antifungal drugs and surgical resection of the intestine involved. At surgery a double covered perforation of the jejunum was seen. Pathological examination confirmed the previous diagnosis. After one year of follow-up the patient is doing well, and his lymphoma is on remission. To our best knowledge this is the second case of intestinal mucormycosis in a patient with Hodgkin's lymphoma reported in the medical literature. PMID:18942905

Madrigal, B; Arenal, J J; Torres, A; Peñarrubia, M J; Vara, A; Ruiz, M; Hernández, A; Enríquez, P

2008-08-01

111

Histopathological correlation of the kiel with the original rappaport classification of malignant non-hodgkin lymphomas  

Microsoft Academic Search

Using the Kiel and the Rappaport classifications, a comparative histopathological analysis of 486 cases with non-Hodgkin lymphomas from a prospective study of the Kiel Lymphoma Study Group, still in progress, was performed. The greater part of Rappaport's classical lymphoma entities was found to be inhomogeneous and to include tumors of considerable prognostic heterogeneity, as shown by differences in actuarial survival.

G. R. F. Krüger; T. Grisar; K. Lennert; E.-W. Schwarze; G. Brittinger

1981-01-01

112

Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series  

Microsoft Academic Search

Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5–30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or

A Furby; A Béhin; J-P Lefaucheur; K Beauvais; P Marcorelles; J-M Mussini; G Bassez; A Créange; B Eymard; I Pénisson-Besnier

2010-01-01

113

Nodular prurigo associated with Hodgkin's disease.  

PubMed

We report a case of prurigo nodularis of Hyde as the presenting sign of Hodgkin's disease in a 22-year-old girl. Though pruritus is a common symptom of Hodgkin's disease, prurigo nodularis has rarely been reported as a Hodgkin's symptom. PMID:1884861

Fina, L; Grimalt, R; Berti, E; Caputo, R

1991-01-01

114

Classical Novae  

NASA Astrophysics Data System (ADS)

Preface; 1. Novae - a historical perspective Hilmar W. Duerbeck; 2. Properties of novae: an overview Brian Warner; 3. The evolution of nova-producing binary stars Icko Iben, Jr and Masayuki Y. Fujimoto; 4. Thermonuclear processes S. Starrfield, C. Iliadis and W. R. Hix; 5. Nova atmospheres and winds P. H. Hauschildt; 6. Observational mysteries and theoretical challenges Jordi Jose and Steven N. Shore; 7. Radio emission from novae E. R. Seaquist and M. F. Bode; 8. Infrared studies of classical novae Robert D. Gehrz; 9. Optical and ultraviolet evolution Steven N. Shore; 10. X-ray emission from classical novae in outburst Joachim Krautter; 11. Gamma-rays from classical novae Margarita Hernanz; 12. Resolved nova remnants T. J. O'Brien and M. F. Bode; 13. Dust and molecules in nova environments A. Evans and J. M. C. Rawlings; 14. Extragalactic novae Allen Shafter; Index.

Bode, Michael F.; Evans, Aneurin

2008-04-01

115

Chinese Americans.  

ERIC Educational Resources Information Center

This book on the Chinese Americans focuses on such aspects of intergroup relations, community characteristics, social problems, acculturation, racial and social discrimination, and economic opportunities for the ethnic group as: the Chinese diaspora; forerunners of overseas Chinese community organization; Chinese community organization in the…

Lyman, Stanford M.

116

Chinese Americans.  

ERIC Educational Resources Information Center

|This book on the Chinese Americans focuses on such aspects of intergroup relations, community characteristics, social problems, acculturation, racial and social discrimination, and economic opportunities for the ethnic group as: the Chinese diaspora; forerunners of overseas Chinese community organization; Chinese community organization in the…

Lyman, Stanford M.

117

Chinese Characters, Chinese Culture and Chinese Mind  

Microsoft Academic Search

Writing forms - whether in terms of Chinese characters and Chinese ideographs, phonetic alphabet or numeric systems - are created by and thus reflect culture, mind, and social reality. In turn, these writing forms exert great impact on the culture and mind of their users. This article contends that in addition to the cultural content that the Chinese writing system

Yuxin Ji; Xuerui Ji

2005-01-01

118

Classical Mechanics  

NASA Astrophysics Data System (ADS)

Bring Classical Mechanics To Life With a Realistic Software Simulation! You can enhance the thorough coverage of Chow's Classical Mechanics with a hands-on, real-world experience! John Wiley & Sons, Inc. is proud to announce a new computer simulation for classical mechanics. Developed by the Consortium for Upper-Level Physics Software (CUPS), this simulation offers complex, often realistic calculations of models of various physical systems. Classical Mechanics Simulations (54881-2) is the perfect complement to Chow's text. Like all of the CUPS simulations, it is remarkably easy to use, yet sophisticated enough for explorations of new ideas. Other Important Features Include: * Six powerful simulations include: The Motion Generator, Rotation of Three-Dimensional Objects, Coupled Oscillators, Anharmonic Oscillators, Gravitational Orbits, and Collisions * Pascal source code for all programs is supplied and a number of exercises suggest specific ways the programs can be modified. * Simulations usually include graphical (often animated) displays. The entire CUPS simulation series consists of nine book/software simulations which comprise most of the undergraduate physics major's curriculum.

Chow, Tai L.

1995-05-01

119

RAND Classics  

NSDL National Science Digital Library

The RAND Corporation has recently added selections from the writings of Albert Wohlstetter to its well known RAND Classics site. Wohlstetter "was a mathematical logician and senior staff member at RAND in the 1950s and 1960s.... His studies led to the 'second-strike' and 'Fail-Safe' concepts for deterring nuclear war. These and other methods reduced the probability of accidental war." At present, 24 selections are available, ranging from 1952 to 1970. More are forthcoming. In addition to Wohlstetter's writings, RAND Classics contains eleven of Paul Baran et al's twelve volume On Distributed Communications (1968), RAND's A Million Random Digits with 100,000 Normal Deviates (1955), and Toward an Ethics and Etiquette for Electronic Mail (1985), by Norman Z. Shapiro and Robert H. Anderson.

1998-01-01

120

Classical Mechanics  

NSDL National Science Digital Library

John Taylor has brought to his new book, Classical Mechanics, all of the clarity and insight that made his Introduction to Error Analysis a best-selling text. Classical Mechanics is intended for students who have studied some mechanics in an introductory physics course, such as âfreshman physics." With unusual clarity, the book covers most of the topics normally found in books at this level, including conservation laws, oscillations, Lagrangian mechanics, two-body problems, non-inertial frames, rigid bodies, normal modes, chaos theory, Hamiltonian mechanics, and continuum mechanics. A particular highlight is the chapter on chaos, which focuses on a few simple systems, to give a truly comprehensible introduction to the concepts that we hear so much about. At the end of each chapter is a large selection of interesting problems for the student, 744 in all, classified by topic and approximate difficulty, and ranging for simple exercises to challenging computer projects.

Taylor, John

2009-09-29

121

Classical Motion  

Microsoft Academic Search

Preciously given rules allow conscious systems to be included in quantum\\u000amechanical systems. There rules are derived from the empirical experience of an\\u000aobserver who witnesses a quantum mechanical interaction leading to the capture\\u000aof a single particle. In the present paper it is shown that purely classical\\u000achanges experienced by an observer are consistent with these rules. Three\\u000adifferent

Richard A Mould

2003-01-01

122

Current therapies in Hodgkin's disease  

Microsoft Academic Search

Advances in the treatment of Hodgkin's disease (HD) have resulted in cure rates of greater than 80%. This remarkable achievement has occurred in the past 50 years secondary to improvements in combination chemotherapy and radiotherapy. Over the last several decades, with the increase in long-term survivors of HD, it has become evident that cure is not the only issue, and

K. E. Kogel; J. W. Sweetenham

2003-01-01

123

What You Need to Know about Non-Hodgkin Lymphoma  

MedlinePLUS

... NCI What You Need To Know About™ Non-Hodgkin Lymphoma In English En español Posted: 02/12/2008 What You Need To Know About? Non-Hodgkin Lymphoma About This Booklet What Is Non-Hodgkin Lymphoma? ...

124

What You Need to Know about Hodgkin Lymphoma  

MedlinePLUS

... About NCI What You Need To Know About™ Hodgkin Lymphoma In English En español Posted: 07/31/2013 What You Need To Know About? Hodgkin Lymphoma About This Booklet The Lymph System Hodgkin Lymphoma ...

125

What Are the Key Statistics about Non-Hodgkin Lymphoma?  

MedlinePLUS

... for non-Hodgkin lymphoma? What are the key statistics about non-Hodgkin lymphoma? Non-Hodgkin lymphoma (NHL) ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...

126

EXPONENTIAL TIME DIFFERENCING FOR HODGKIN-HUXLEY-LIKE ODES  

PubMed Central

Several authors have proposed the use of exponential time differencing (ETD) for Hodgkin–Huxley-like partial and ordinary differential equations (PDEs and ODEs). For Hodgkin–Huxley-like PDEs, ETD is attractive because it can deal effectively with the stiffness issues that diffusion gives rise to. However, large neuronal networks are often simulated assuming “space-clamped” neurons, i.e., using the Hodgkin–Huxley ODEs, in which there are no diffusion terms. Our goal is to clarify whether ETD is a good idea even in that case. We present a numerical comparison of first- and second-order ETD with standard explicit time-stepping schemes (Euler’s method, the midpoint method, and the classical fourth-order Runge–Kutta method). We find that in the standard schemes, the stable computation of the very rapid rising phase of the action potential often forces time steps of a small fraction of a millisecond. This can result in an expensive calculation yielding greater overall accuracy than needed. Although it is tempting at first to try to address this issue with adaptive or fully implicit time-stepping, we argue that neither is effective here. The main advantage of ETD for Hodgkin–Huxley-like systems of ODEs is that it allows underresolution of the rising phase of the action potential without causing instability, using time steps on the order of one millisecond. When high quantitative accuracy is not necessary and perhaps, because of modeling inaccuracies, not even useful, ETD allows much faster simulations than standard explicit time-stepping schemes. The second-order ETD scheme is found to be substantially more accurate than the first-order one even for large values of ?t.

Borgers, Christoph; Nectow, Alexander R.

2013-01-01

127

Serum macrophage colony-stimulating factor (M-CSF) in patients with Hodgkin lymphoma.  

PubMed

Macrophage colony-stimulating factor (M-CSF) was recently implicated by in vitro studies as a survival and proliferation factor for Hodgkin/Reed-Sternberg cells. We evaluated pre-treatment serum M-CSF levels in 66 patients with histopathologic diagnosis of classical Hodgkin lymphoma (HL) and looked for possible correlations with baseline clinical characteristics. Significantly higher M-CSF serum concentrations were found in patients with bulky mediastinal mass, systemic symptoms, and elevated ESR but not LDH. There was no significant association between M-CSF level and sex, clinical stage, number of lymph node areas involved, and histopathological subtype of HL. We conclude that serum M-CSF levels are frequently elevated in HL patients and are significantly related to the presence of bulky mediastinal mass and systemic symptoms. These observations may indicate a pathogenetic role of M-CSF in Hodgkin lymphoma. PMID:21717212

Kowalska, Maria; Tajer, Joanna; Chechlinska, Magdalena; Fuksiewicz, Malgorzata; Kotowicz, Beata; Kaminska, Janina; Walewski, Jan

2011-06-30

128

Costs and effectiveness of staging and treatment options in early-stage Hodgkin’s disease  

Microsoft Academic Search

Purpose: Using a cost-effectiveness analysis, to weigh the costs and benefits of the different staging and treatment options in early-stage Hodgkin’s disease.Methods: We constructed a decision-analytic model for a hypothetical cohort of 25-year-old patients with early-stage Hodgkin’s disease. Markov models were used to simulate the lifetime costs and prognosis of each staging and treatment strategy. Baseline probabilities and cost estimates

Andrea K. Ng; Karen M. Kuntz; Peter M. Mauch

2001-01-01

129

The Role of Chemotherapy in Hodgkin's Lymphoma  

PubMed Central

The development of curative chemotherapy regimens for the treatment of Hodgkin’s lymphoma is one of the true success stories in oncology. Most patients diagnosed with Hodgkin’s lymphoma today can be cured. The major task remaining before us is curing as many patients as possible with their initial therapeutic approach while minimizing the acute toxicities and limiting the lifetime risks of important secondary events such as cardiovascular complications and secondary malignancies. In the 40 years since DeVita and colleagues developed the MOPP (Mechlorethamine, Vincristine, Procarbazine, Prednisone) chemotherapy regimen, we have learned a great deal about risk stratification to minimize treatment-related toxicity. Positron-emission tomography may further assist us in reducing radiation treatment without compromising cures. This review will discuss the development of the chemotherapy regimens used in the management of early and advanced stage Hodgkin’s lymphoma and the advantages and disadvantages of their use in combination with radiation therapy.

Seam, Pamela; Janik, John E.; Longo, Dan L.; DeVita, Vincent T.

2009-01-01

130

Chinese Literature  

ERIC Educational Resources Information Center

|The earliest recorded Chinese literature that has survived consists of folk songs mixed with verses and rhymes. Two factors determined the general pattern of subsequent development in Chinese literature: the nature of the written Chinese language and the establishment of the Confucian school as the orthodoxy in literary criticism. By 1800 there…

Hsu, Kai-yu

131

Genomic Instability: The Driving Force behind Refractory/Relapsing Hodgkin's Lymphoma  

PubMed Central

In classical Hodgkin’s lymphoma (HL) the malignant mononuclear Hodgkin (H) and multinuclear, diagnostic Reed-Sternberg (RS) cells are rare and generally make up <3% of the total cellular mass of the affected lymph nodes. During recent years, the introduction of laser micro-dissection techniques at the single cell level has substantially improved our understanding of the molecular pathogenesis of HL. Gene expression profiling, comparative genomic hybridization analysis, micro-RNA expression profiling and viral oncogene sequencing have deepened our knowledge of numerous facets of H- and RS-cell gene expression deregulation. The question remains whether disturbed signaling pathways and deregulated transcription factors are at the origin of refractory/relapsing Hodgkin’s lymphoma or whether these hallmarks are at least partially related to another major factor. We recently showed that the 3D nuclear organization of telomeres and chromosomes marked the transition from H- to RS-cells in HL cell lines. This transition is associated with progression of telomere dysfunction, shelterin disruption and progression of complex chromosomal rearrangements. We reported analogous findings in refractory/relapsing HL and identified the shelterin proteins TRF1, TRF2 and POT1 as targets of the LMP1 oncogene in post-germinal center B-cells. Here we summarize our findings, including data not previously published, and propose a model in which progressive disruption of nuclear integrity, a form of genomic instability, is the key-player in refractory/relapsing HL. Therapeutic approaches should take these findings into account.

Knecht, Hans; Righolt, Christiaan; Mai, Sabine

2013-01-01

132

On the Contextual Turn in the Tokugawa Japanese Interpretation of the Confucian Classics: Types and Problems  

Microsoft Academic Search

This article discusses the “contextual turn” in the interpretation of Chinese classics: the contextuality of Confucian classics\\u000a in China was latent, tacit, and almost imperceptible; however, it became salient and explicit once the Confucian classics\\u000a were introduced to Tokugawa Japan. Many a Japanese Confucian took ideas and values expressed in the Chinese classics and transplanted\\u000a them into the context of

Chun-Chieh Huang

2010-01-01

133

Care of the Adult Hodgkin Lymphoma Survivor  

PubMed Central

Of those individuals diagnosed with Hodgkin lymphoma, 85% will survive and may be affected by residual effects of their cancer and its therapy (chemotherapy, radiation therapy, stem cell transplantation). Hodgkin lymphoma survivors are at risk of developing secondary malignancies, cardiovascular disease, pulmonary disease, thyroid disease, infertility, premature menopause, chronic fatigue, and psychosocial issues. These conditions usually have a long latency and therefore present years or decades after Hodgkin lymphoma treatment, when the patient’s care is being managed by a primary care provider. This review summarizes these unique potential medical and psychological sequelae of Hodgkin lymphoma, and provides screening and management recommendations.

Thompson, Carrie A.; Mauck, Karen; Havyer, Rachel; Bhagra, Anjali; Kalsi, Henna; Hayes, Sharonne N.

2011-01-01

134

Treatment of Pediatric Hodgkin Lymphoma  

Microsoft Academic Search

Opinion statement  We are increasingly successful in the treatment of Hodgkin lymphoma. Current risk adapted trials seek to maintain the excellent\\u000a efficacy of older therapies, while simultaneously limiting their late toxicities. Current management of early stage\\/favorable\\u000a disease involves the use of two to four cycles of tailored chemotherapy, often followed by low-dose, involved field radiation.\\u000a Those with intermediate and advanced stage

Michael R. Olson; Sarah S. Donaldson

2008-01-01

135

Mediastinal choriocarcinoma masquerading as relapsed hodgkin lymphoma.  

PubMed

Primary mediastinal choriocarcinoma is a rare extragonadal germ cell malignancy. We describe the first case of a patient who developed mediastinal choriocarcinoma after treatment for Hodgkin lymphoma (HL). A 25-year-old man with classic HL, nodular sclerosis subtype, underwent treatment with splenectomy followed by radiation therapy. Unfortunately, his disease relapsed with a paraspinal mass, and he was subsequently treated with MOPP (mechlorethamine, Oncovin, procarbazine, and prednisone) alternating with ABVD (Adriamycin, bleomycin, vinblastine, and dacarbazine). He achieved a complete remission after 6 cycles. Ten years after treatment, the patient presented with a persistent cough, haemoptysis, right supraclavicular lymphadenopathy, and weight loss. His chest X-ray showed opacification of the lower right hemithorax with a widened mediastinum. Given unresponsiveness to several antibiotics and lack of evidence for lung volume loss, there were concerns over lung infiltration with relapsed lymphoma. Transbronchial fine needle aspiration biopsy suggested recurrence of his HL. MOPP alternating with ABVD was again given. Due to disease progression, brachytherapy as well as a cocktail of dexamethasone, cytarabine, and cisplatin were also tried. However, on a subsequent excisional lymph node biopsy, it turned out that the tumour was in fact choriocarcinoma and not relapsed HL. Unfortunately, despite aggressive therapy, the patient's disease rapidly progressed, and he died within 2 weeks. PMID:22114578

Lam, Selay; Rizkalla, Kamilia; Hsia, Cyrus C

2011-10-14

136

Favorable early-stage Hodgkin lymphoma.  

PubMed

The category of favorable early-stage Hodgkin lymphoma (HL) includes patients with Ann Arbor stages I or II disease with no bulky disease or B symptoms. The precise definition of favorable versus unfavorable early-stage disease may vary among American and European cooperative groups. The overall 10-year survival rate of patients with favorable early-stage HL exceeds 90%. Indeed, effective treatments for this group of patients have been available for more than 4 decades. However, treatment strategies have radically changed over the past 15 years and focus now on maintaining the high cure rate while reducing the risk of treatment-related long-term morbidity. The optimal treatment is still evolving, and more recently, reduction in the total amount of chemotherapy and in radiation field and dose has shown excellent results. Combined modality therapy is the preferred treatment for patients with classical favorable early-stage HL (nodular sclerosis or mixed cellularity histology). Patients with early-stage lymphocyte predominance HL are highly curable using involved-field radiation therapy (IFRT) alone and do not require chemotherapy. Classical favorable HL is also curable with radiotherapy alone or with chemotherapy alone, but larger fields and higher-dose radiation or longer chemotherapy is required compared with combined modality. The freedom from treatment failure rate is significantly better with a combination of short chemotherapy and IFRT than with either chemotherapy or radiotherapy alone. Although combined modality is the standard preferred treatment for favorable disease, radiation therapy alone or chemotherapy alone could be considered under special circumstances or as part of an investigational protocol. PMID:16507270

Yahalom, Joachim

2006-03-01

137

Characterization of Hodgkin's lymphoma-like undifferentiated carcinoma of the nasopharyngeal type as a particular UCNT subtype mimicking Hodgkin's lymphoma.  

PubMed

Undifferentiated carcinoma of the nasopharyngeal type (UCNT) that histologically mimics Hodgkin's lymphoma (HL) ("Hodgkin's lymphoma-like UCNT"--HL-like UCNT) is known as a diagnostic pitfall. Using immunohistochemistry, Western blot and cDNA array technology, we wanted to document its phenotypical and molecular characteristics. We report herein 5 cases of UCNT that morphologically mimic HL and 3 classical UCNT cases. We compared the expression profiles of a thousand selected genes in HL-like UCNT and in classical UCNT cases. No difference in the profile of EBV infection was noted between the HL-like UCNT and control cases. Significant differences were detected in the expression of genes involved in the matrix modelling, angiogenesis, apoptosis and regulation of the Th-2 interleukins. The eosinophil chemoattractant eotaxin was expressed in the stroma of HL-like UCNT, but not in the control cases. The eotaxin receptor CCR3 was expressed in both stromal and carcinoma cell populations of HL-like UCNT, this pattern being similar to the one observed in HL. These results show that UCNT morphologically resembling HL share also some specific phenotypical and molecular features with HL, and might deserve to be isolated as a particular UCNT subtype. PMID:12792781

Charafe-Jauffret, Emmanuelle; Bertucci, François; Ramuz, Olivier; Devilard, Elisabeth; Gaulard, Philippe; Brousset, Pierre; Houlgatte, Remi; Hassoun, J; Birnbaum, Daniel; Xerri, Luc

2003-07-01

138

On the aetiology of Hodgkin lymphoma.  

PubMed

The thesis is based on seven publications in English and a review of the literature. The studies were carried out to contribute to the understanding of Hodgkin lymphoma epidemiology through descriptions of its occurrence and its association with Epstein-Barr virus (EBV) infection presenting as infectious mononucleosis. The investigations were supported by the Danish Cancer Society, the Swedish Cancer Society, the Danish Cancer Research Foundation, the Nordic Cancer Union, the Lundbeck Foundation, Plan Danmark, Danish National Research Foundation, Lily Benthine Lund's Foundation, Aase og Ejnar Danielsen's Foundation, Grosserer L. F. Foght's Foundation, the Leukaemia Reseach Fund, the Kay Kendall Leukaemia Fund, and the U.S. National Institutes of Health. The work was carried out in the period 1999-2010 during my employment at the Department of Epidemiology Research at Statens Serum Institut. The employed study designs included population-based incidence surveys of Hodgkin lymphoma in the Nordic countries and in Singapore, register-based cohort studies to characterise the pattern of cancer occurrence in patients with infectious mononucleosis and their first degree relatives, a register-based cohort and a population-based case-control study to characterise the association between infectious mononucleosis and Hodgkin lymphoma taking tumour EBV-status into consideration, and a case-series analysis to assess the association between HLA class I alleles and EBV-positive and EBV-negative Hodgkin lymphomas. Analyses of Nordic incidence data demonstrated that the occurrence of Hodgkin lymphoma had increased markedly younger adults in the period 1978-97, whereas it had decreased among older adults. In combination, these developments led to an accentuation of the younger adult Hodgkin lymphoma incidence peak, which has been a hallmark of Hodgkin lymphoma epidemiology in the Western hemisphere for more than a half century. The opposing incidence trends in younger and older adults are consistent with the prevailing hypothesis of aetiological heterogeneity between Hodgkin lymphomas in different age groups. In contrast to Western industrialised countries, absence of a younger adult incidence peak has been a characteristic of Hodgkin lymphoma epidemiology in developing and Asian populations. A survey of Hodgkin lymphoma occurrence in Singapore 1968-2002 revealed increasing incidence rates and the emergence of an incidence peak in younger adults. The appearance of a younger adult incidence peak in conjunction to socio-economic transition towards Western world lifestyle in Singapore is compatible with the suspicion that Hodgkin lymphoma in younger adults is associated with correlates of socioeconomic affluence in childhood, such as delayed exposure to childhood infectious agents. EBV can be demonstrated in the malignant cells in a subset of Hodgkin lymphomas and it has been speculated that the virus' presence and absence may distinguish between aetiologically separate Hodgkin lymphoma entities. This possibility was explored in five investigations characterising the association between infectious mononucleosis and Hodgkin lymphoma. In these studies, infectious mononucleosis was not accompanied by an increased risk of cancer in general, but specifically with an increased risk of Hodgkin lymphoma. The increased risk of Hodgkin lymphoma decreased with time since infectious mononucleosis and because of the typical adolescent age at infectious mononucleosis it was most prominent for Hodgkin lymphoma in younger adults. Supplementing studies provided little support for the notion that the observed association between Hodgkin lymphoma and infectious mononucleosis was explained by confounding or biases. Analyses stratified by Hodgkin lymphoma EBV status indicated that the increased risk after infectious mononucleosis was confined to the subset of Hodgkin lymphomas that harbour the virus in the malignant cells. The genetic analyses pointed to increased and decreased risk of EBV-positive Hodgkin lymphoma associated with HLA-A*01 and HLA-A*02 alleles, r

Hjalgrim, Henrik

2012-07-01

139

Hodgkin lymphoma of the oral mucosa.  

PubMed

In this report, we describe a rare case of relapsed nodular sclerosing Hodgkin lymphoma presenting as a lesion of the oral mucosa. Although this is an uncommon clinical scenario, health care professionals should be aware of this possibility. A brief differential diagnosis and review of Hodgkin lymphoma is discussed. PMID:22736151

Darling, Mark R; Cuddy, Karl K; Rizkalla, Kamilia

2012-06-27

140

The Pathology and Nomenclature of Hodgkin's Disease  

Microsoft Academic Search

Summary The diverse morphologic expressions of Hodgkin's disease have been reviewed and compared to the numerous histologie terms in the literature and the author's recently proposed histologie types. The relationship of the histologie findings to the clinical stages and survival has also been analyzed. The histologie ex pressions of the Hodgkin's disease process appear to be reparable into the following

ROBERT J. LUKES; JAMES J. BUTLER

141

Hemorrhagic Cystitis due to BK Reactivation in a Young Female Treated for Hodgkin-Disease  

PubMed Central

Hodgkin's lymphoma is a disease with a high rate of curability under classic chemo-radiotherapy regimes. Complications due to chemotherapy could include viral reactivation due to chronic lymphopenia. BK virus (BKV) is a polyoma virus belonging to the Papovaviridae family with antibody seroprevalences in healthy populations varying from 60% to 80%. Initial infections are asymptomatic usually occur in early childhood, after which the viruses remain latent in the kidneys or urothelium. Reactivation of BKV occurs in individuals with severe immunosuppression during HIV infections, transplantation or, exceptionally, after classical chemotherapy. BKV incidence is approximately 0% to 5% in immunocompetent individuals. Reactivation is associated with nephropathy and haemorrhagic cystitis. Herein, we present a case of a haemorrhagic cystitis due to BKV reactivation in a patient with Hodgkin's disease treated with chemotherapy.

Le Calloch, R.; Ianotto, J. C.; Berthou, C.; Tempescul, A.

2011-01-01

142

Hodgkin's Lymphoma: A Review of Neurologic Complications  

PubMed Central

Hodgkin's lymphoma is a hematolymphoid neoplasm, primarily of B cell lineage, that has unique histologic, immunophenotypic, and clinical features. Neurologic complications of Hodgkin's Lymphoma can be separated into those that result directly from the disease, indirectly from the disease, or from its treatment. Direct neurologic dysfunction from Hodgkin's Lymphoma results from metastatic intracranial spinal disease, epidural metastases causing spinal cord/cauda equina compression, leptomeningeal metastases, or intradural intramedullary spinal cord metastases. Indirect neurologic dysfunction may be caused by paraneoplastic disorders (such as paraneoplastic cerebellar degeneration or limbic encephalitis) and primary angiitis of the central nervous system. Hodgkin's lymphoma treatment typically includes chemotherapy or radiotherapy with potential treatment-related complications affecting the nervous system. Neurologic complications resulting from mantle-field radiotherapy include the “dropped head syndrome,” acute brachial plexopathy, and transient ischemic attacks/cerebral infarcts. Chemotherapy for Hodgkin's lymphoma may cause cerebral infarction (due to emboli from anthracycline-induced cardiomyopathy) and peripheral neuropathy.

Grimm, Sean; Chamberlain, Marc

2011-01-01

143

Hodgkin's Lymphoma: A Review of Neurologic Complications.  

PubMed

Hodgkin's lymphoma is a hematolymphoid neoplasm, primarily of B cell lineage, that has unique histologic, immunophenotypic, and clinical features. Neurologic complications of Hodgkin's Lymphoma can be separated into those that result directly from the disease, indirectly from the disease, or from its treatment. Direct neurologic dysfunction from Hodgkin's Lymphoma results from metastatic intracranial spinal disease, epidural metastases causing spinal cord/cauda equina compression, leptomeningeal metastases, or intradural intramedullary spinal cord metastases. Indirect neurologic dysfunction may be caused by paraneoplastic disorders (such as paraneoplastic cerebellar degeneration or limbic encephalitis) and primary angiitis of the central nervous system. Hodgkin's lymphoma treatment typically includes chemotherapy or radiotherapy with potential treatment-related complications affecting the nervous system. Neurologic complications resulting from mantle-field radiotherapy include the "dropped head syndrome," acute brachial plexopathy, and transient ischemic attacks/cerebral infarcts. Chemotherapy for Hodgkin's lymphoma may cause cerebral infarction (due to emboli from anthracycline-induced cardiomyopathy) and peripheral neuropathy. PMID:20975772

Grimm, Sean; Chamberlain, Marc

2010-10-11

144

Idiopathic thrombocytopaenic purpura in patients during remission of Hodgkin's disease.  

PubMed

Four patients with Hodgkin's disease developed thrombocytopaenic purpura during remission phase. The interval at which it occurred following chemotherapy ranged from a period of 4 months to 4 years. Detailed investigations failed to reveal recurrence of Hodgkin's disease. All patients responded well to steroid therapy. In the median duration of one year follow-up Hodgkin's disease remained under control. Thus, the occurrence of thombocytopaenic purpura in patients treated for Hodgkin's lymphoma need not imply recurrence or active Hodgkin's disease. PMID:2808278

Tahiliani, R R; Banavali, S D; Parikh, P M; Charak, B S; Nair, C N; Saikia, T K; Gopal, R; Advani, S H

1989-02-01

145

[Pediatric non-Hodgkin lymphomas].  

PubMed

Non Hodgkin lymphoma represent about 5% of childhood cancer. They are the third most common group of cancers in children and adolescents, after cerebral tumours and leukemias. They differ from adult lymphomas as they are all high grade tumours, always diffuse and often associated with extra-nodal diseases. Three main histological subtypes predominate: Burkitt, lymphoblastic and anaplastic large cell lymphomas. As the clinical progression is growing fast and treatment different between the 3 subtypes, the diagnosis must be rapidly done and with accuracy. PMID:15785404

Brousse, Nicole; Vasiliu, Viorel; Michon, Jean; Canioni, Danielle

2004-12-01

146

Chinese Cooking.  

ERIC Educational Resources Information Center

|This unit, intended for secondary level students, is a general introduction to Chinese cooking. It is meant to inform students about the origins of Chinese cooking styles in their various regional manifestations, and it can be used to discuss how and why different cultures develop different styles of cooking. The first part of the unit, adapted…

Kane, Tony

147

Business Chinese.  

ERIC Educational Resources Information Center

The instructional guide to business Chinese consists of 12 two-part specially composed narrative essays on all aspects of Chinese foreign trade ranging from broad principles and policies to details of operation and procedure. Each lesson is followed by a summary of its main points, 10 questions to guide discussion or conversational practice, and a…

Wang, John, Comp.; And Others

148

Hodgkin lymphoma in Tyrol-a population-based study.  

PubMed

We aimed to analyze the epidemiology, clinical characteristics, and outcome of patients with Hodgkin lymphoma (HL) diagnosed in Tyrol. All patients with newly diagnosed HL between 1993 and 2005 were included in this study. Among the 158 cases included, nodular lymphocytic predominant HL (nodular paragranuloma) was identified in ten cases (6%) whereas the majority of patients had classical Hodgkin lymphoma. Age (p < 0.01), sex (p = 0.03), risk groups according to the German Hodgkin Study Group stratification (p < 0.01), and bone marrow infiltration (p < 0.01) were of prognostic significance considering overall survival (OS) whereas histological subtype and bulky disease were not. The 5- and 10-year OS rates for the total group were 89% and 85%, respectively. Notably, in patients with advanced-stage HL (n = 49), combined modality treatment resulted in significantly better OS than chemotherapy alone (p = 0.01). Three patients developed a second hematological malignancy and one patient developed breast cancer. However, five patients (3%) had a malignant hematological disorder before occurrence of HL. Concerning treatment-related toxicity, bleomycin-associated lung toxicity was observed in six (4%) patients and five (3%) developed lethal treatment-related infectious complications. Our results provide evidence that the incidence rate of HL in Tyrol is comparable to other Western countries. Modern risk-adapted treatment results in excellent long-term prognosis but may be complicated by serious nonhematological side effects, in particular, infections and bleomycin-induced lung toxicity. Furthermore, 3% of HL patients had an antecedent malignant hematological disease before occurrence of HL. PMID:18846373

Fong, Dominic; Steurer, Michael; Greil, Richard; Gunsilius, Eberhard; Spizzo, Gilbert; Gastl, Guenther; Tzankov, Alexandar

2008-10-10

149

Staging laparotomy in Hodgkin's disease.  

PubMed

Staging laparotomy was performed at the University of Virginia Medical Center on 111 patients with Hodgkin's disease. The operation included multiple liver and lymph node biopsies and, excepting three patients, splenectomy. The histopathology was reviewed and the 111 patients were classified as follows: nodular sclerosis, 74; mixed cellularity, 28; lymphocyte predominance, 7; and undetermined, 2. There were no deaths. Wound, pulmonary or urinary tract complications occurred in 11 patients. One case of postoperative thrombophlebitis occurred and in another case small bowel obstruction developed, and resolved without reoperation. The pathologic stage (PS) following laparotomy was unchanged from the clinical stage (CS) in 64%, reduced in 20%, and advanced in 16%. The therapy, however, was altered in 38% of the patients. Lymphangiography in 103 patients was interpreted as showing lymph node involvement in 38, equivocal involvement in 11, and no involvement in 54. Among the 92 examinations reported as either positive or negative, 77% were confirmed histopathologically, 21% were falsely positive, and 2% were falsely negative. The spleen was positive for Hodgkin's disease in 39% of cases, and in these patients with positive spleens there was no reason to suspect intra-abdominal involvement preoperatively in 21%. PMID:646487

Sandusky, W R; Jones, R C; Horsley, J S; Marsh, W L; Tillack, T W; Tegtmeyer, C J; Hess, C E

1978-05-01

150

Memristor, hodgkin-huxley, and edge of chaos.  

PubMed

From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm's law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of 'pinched' hysteresis loops in the v-i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin-Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin-Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling 'Goldilocks zone', dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors. PMID:23999613

Chua, Leon

2013-09-02

151

Memristor, Hodgkin–Huxley, and Edge of Chaos  

NASA Astrophysics Data System (ADS)

From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm’s law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of ‘pinched’ hysteresis loops in the v–i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin–Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin–Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling ‘Goldilocks zone’, dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors.

Chua, Leon

2013-09-01

152

Hodgkin's disease manifesting as prurigo nodularis.  

PubMed

Prurigo nodularis is an uncommon pediatric cutaneous disorder that is associated with intense pruritus. We report a teenager with prurigo nodularis as the presenting sign of stage IIA Hodgkin's disease, primarily in the mediastinum. The pruritus and associated cutaneous lesions resolved with combination chemotherapy directed at the malignancy. In patients with prurigo nodularis and pruritus of unclear etiology, the possibility of underlying Hodgkin's disease must be considered. PMID:2359730

Shelnitz, L S; Paller, A S

1990-06-01

153

Hodgkin disease and non-Hodgkin lymphomas in children: utilization of radiological modalities  

Microsoft Academic Search

If costs of medical care are to be reduced, the choice of which imaging modality to use must be made as carefully as possible. This study was done to show how radiological modalities were used to evaluate patients with Hodgkin disease and non-Hodgkin lymphoma. We kept a record of every radiological study performed on 66 children with both diseases seen

M. D. Cohen; A. Siddiqui; R. Weetman; A. Provisor; T. Coates

1986-01-01

154

Rare Cases of Primary Pleural Hodgkin and Non-Hodgkin Lymphomas  

Microsoft Academic Search

Primary pleural lymphoma is rare. It occurs in only 7% of lymphoma cases. We report herein two cases of primary pleural Hodgkin and non-Hodgkin follicular lymphomas diagnosed by thoracoscopy under local anesthesia. Both patients presented initially with dyspnea revealing pleural effusions. The pleural findings during thoracoscopy differed in the two cases and selective pleural biopsies under optical forceps led to

Paschalis Steiropoulos; George Kouliatsis; Georgia Karpathiou; Maria Popidou; Marios E. Froudarakis

2009-01-01

155

Computerised tomography in the staging of Hodgkin's disease and non-Hodgkin's lymphoma  

Microsoft Academic Search

The last 25 years have seen major changes in the imaging investigation and subsequent management of patients with Hodgkin's disease (HD) and non-Hodgkin's lymphoma (NHL); accurate staging is vital for prognostication and treatment in both, and particularly in HD. The choice of imaging modality for staging depends on its accuracy, impact on clinical decision-making, and availability. Modern CT scanners fulfil

Sarah J. Vinnicombe; Rodney H. Reznek

2003-01-01

156

Radiation-induced splenic atrophy in patients with Hodgkin's disease and non-Hodgkin's lymphomas  

SciTech Connect

Effective treatment of Hodgkin's disease requires the determination of the extent of the disease. This usually involves staging laparotomy, which includes splenectomy and biopsies of the para-aortic lymph nodes, liver, and bone marrow. Absence of the spleen predisposes a person to fulminant septicemia from encapsulated bacteria, a risk even greater in patients undergoing treatment for Hodgkin's disease. For this reason, some investigators have suggested that spleens not be removed for diagnosis but, rather, that they be included within the fields of radiation, which would preserve normal splenic function. We present a case of fatal spontaneous pneumococcal sepsis in a patient with splenic atrophy; the sepsis occurred 12 years after successful treatment of Hodgkin's disease by total nodal and splenic irradiation. A retrospective study of patients treated for Hodgkin's and non-Hodgkin's lymphomas indicated that atrophy and functional asplenia may be an important sequela of splenic irradiation.

Dailey, M.O.; Coleman, C.N.; Kaplan, H.S.

1980-01-24

157

[The impact of the study of contemporary and Confucian comments on the classic Neijing (Internal Classic) and its commentary and subcommentary].  

PubMed

The argumentation between the contemporary and old Confucian classics schools had a profound and lasting impact on the Traditional Chinese Academy, so as to evolve into two kinds of attitude towards the scholarship which influenced TCM which was based on traditional Chinese culture. These impacts reflected in the following three aspects: first, the differences between the words of different versions of Neijing (Internal Classic); second, the formation of some theories of Neijing (Internal Classic) such as the attachment of five zang-organs and five phases; third, the annotated methods for (Neijing (Internal Classic) of the physicians of past generations. PMID:20973276

Zhou, Qi; Liu, Chang-hua

2010-03-01

158

Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review.  

PubMed

Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persistent cough, pruritus, and ten-pound weight lost during this time. The CBC revealed hemoglobin of 5.9?gm/dL, and direct Coomb's test detected multiple nonspecific antibodies consistent with the diagnosis of AIHA. Chest, abdomen, and pelvic CT scan showed mediastinal lymphadenopathy and splenomegaly. Lymph node biopsy revealed classic LRHL. AIHA resolved after completion of the first cycle of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD); after six cycles, he went into complete remission. Although infrequent, AIHA can be responsible for the presenting symptoms of HL. PMID:22937306

Hurtado-Cordovi, Jorge M; Verma, Vaibhav; Gotlieb, Vladimir; Frieri, Marianne

2011-09-28

159

Lymphocyte Rich Hodgkin's Lymphoma Presented with Warm Hemolytic Anemia: A Case Report and Literature Review  

PubMed Central

Hodgkin's lymphoma accounts for ten percent of all lymphomas. In the United States, there are about 8000 new cases every year. This paper describes a case of lymphocyte-rich Hodgkin's lymphoma (LRHL) manifested by autoimmune hemolytic anemia (AIHA). A 27-year-old Israeli male presented with dizziness associated with one month of low-grade fevers and night sweats; he also complained of persistent cough, pruritus, and ten-pound weight lost during this time. The CBC revealed hemoglobin of 5.9?gm/dL, and direct Coomb's test detected multiple nonspecific antibodies consistent with the diagnosis of AIHA. Chest, abdomen, and pelvic CT scan showed mediastinal lymphadenopathy and splenomegaly. Lymph node biopsy revealed classic LRHL. AIHA resolved after completion of the first cycle of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD); after six cycles, he went into complete remission. Although infrequent, AIHA can be responsible for the presenting symptoms of HL.

Hurtado-Cordovi, Jorge M.; Verma, Vaibhav; Gotlieb, Vladimir; Frieri, Marianne

2011-01-01

160

An algorithm for the hierarchical Chinese postman problem  

Microsoft Academic Search

The Hierarchical Chinese Postman Problem (HCPP) is a variant of the classical Chinese Postman Problem, in which the arcs are partitioned into clusters and a precedence relation is defined on clusters. Practical applications of the HCPP include snow and ice control on the roads and determination of optimal torch paths in flame cutting. The HCPP is NP-hard in general, but

Gianpaolo Ghiani; Gennaro Improta

2000-01-01

161

Ancient Greek and Chinese Patterns of Definition: A Comparative Study  

Microsoft Academic Search

This study contributes to the understanding of the difference between Western and Chinese thought by comparing the cultural patterns of definition in ancient Greece and China, two cultures that have, in many ways, come to define the West and East. Current studies of the classical period of these two ancient cultures have focused on what the Greek and Chinese sages

Xiaosui Xiao

2008-01-01

162

Maoism versus Confucianism: ideological influences on Chinese business leaders  

Microsoft Academic Search

Purpose – This paper seeks to propose that practical wisdom originating within the Chinese classical traditions has been instrumental in China's ascendance to the world stage. Its purpose is to analyze biographical data across 200 Chinese business leaders in order to gauge the relative influence of two competing ideologies – Maoism and Confucianism. Design\\/methodology\\/approach – This paper is based on

Paul McDonald

2011-01-01

163

The bcl-2 Oncogene in Hodgkin's Disease Arising in the Setting of Follicular Non-Hodgkin's Lymphoma  

Microsoft Academic Search

HE PATHOGENESIS OF Hodgkin's disease (HD) and the origin of the Reed-Sternberg cell and its variants (Hodgkin cells), the neoplastic cells of HD, have been the subject of much study and debate. Over the years, granulo- cytes, histiocytes, and interdigitating reticulum cells have been proposed as the cell of origin of Hodgkin cells, but more prominent in the recent literature

David P. LeBrun; Bo-Yee Ngan; Lawrence M. Weiss; Philip Huie; Roger A. Warnke; Michael L. Cleary

1994-01-01

164

Bilateral breast cancer after cured Hodgkin's disease  

SciTech Connect

Three patients developed bilateral breast cancer at 10 to 24 years after mantle irradiation for locally or systemically advanced Hodgkin's disease (HD). Four of the six cancers in the three patients were detected only by mammography. Pathologically, five of the cancers were intraductal carcinomas (four with an invasive component) with one being a lobular carcinoma. Five of the six lesions were Stage I pathologically without evidence of axillary nodal involvement. It is recommended that female patients with Hodgkin's disease who have received mantle irradiation as part of the therapy for their Hodgkin's disease and who are observed for 10 or more years after completion of mantle irradiation be considered at risk for the development of breast cancer. Such patients should be monitored appropriately by routine bilateral mammograms to increase the early detection of early stage lesions.

Anderson, N.; Lokich, J. (New England Baptist Hospital, Boston, MA (USA))

1990-01-15

165

Maternal and foetal outcome following Hodgkin's disease in pregnancy.  

PubMed Central

The peak incidence of Hodgkin's disease occurs during the reproductive age, and its association with pregnancy is at a rate of between 1:1,000-1:6,000. We studied the effects of Hodgkin's Disease on the course and survival of 48 women who had Hodgkin's Disease and who were pregnant, and compared their outcome with non-pregnant matched women who were of similar stage of disease, age at diagnosis, and calenderic year of treatment. Twenty-year survival of pregnant women with Hodgkin's Disease was not different from that of their matched controls. Pregnant women with Hodgkin's Disease had similar distribution of stages to the controls.

Lishner, M.; Zemlickis, D.; Degendorfer, P.; Panzarella, T.; Sutcliffe, S. B.; Koren, G.

1992-01-01

166

Chinese Connections  

ERIC Educational Resources Information Center

|When L. Brooks Patterson, the executive of Oakland County, Michigan, publicly called for the county to become the first in America to teach Mandarin Chinese in every public school district, the Oxford Community Schools responded immediately. Over the past four years, the school district of 5,030 students in southeastern Michigan has elevated the…

Skilling, William C.

2012-01-01

167

Epstein-Barr virus-associated lymphoproliferative disorder developed following autologous peripheral blood stem cell transplantation for relapsing Hodgkin's lymphoma  

PubMed Central

Post-transplant lymphoproliferative disorders (PTLDs) are lymphoid or plasmacytic proliferations that develop as a consequence of immunosuppression in a recipient of a solid organ, bone marrow or stem cell allograft. The development of PTLDs is usually associated with Epstein-Barr virus (EBV) and the disorder is also termed EBV-associated lymphoproliferative disorder (LPD). The development of PTLD is a rare complication in autologous bone marrow/peripheral blood stem cell transplantation. In the present study, we report a case of EBV-associated LPD which developed following autologous peripheral blood stem cell transplantation for relapsing Hodgkin’s lymphoma. A 51-year-old male presented with swelling of the left cervical lymph nodes. A biopsy revealed nodular sclerosis classical Hodgkin’s lymphoma. Following four courses of ABVd (adriamycin, bleomycin, vinblastine, dacarbazine) therapy, the Hodgkin’s lymphoma relapsed. CHASE (cyclophosphamide, etoposide, cytarabine, dexamethasone) therapy and autologous peripheral blood stem cell transplantation were performed. In the 128 days following the transplantation, lymph node swelling was noted and a biopsy specimen demonstrated EBV-associated LPD. The serum copy number of EBV-DNA was 2.7×103 copies/ml. The occurrence of EBV-associated LPD may be on the rise due to the increased number of patients undergoing immunosuppression therapy. The measurement of the serum EBV-DNA copy number and the detection of EBV-infected atypical lymphocytes using in situ hybridization are significant in establishing an early accurate diagnosis and initiating the correct treatment for EBV-associated LPD in patients with immunosuppression.

IZUMIYA, SAKURA; ISHIDA, MITSUAKI; HODOHARA, KEIKO; YOSHIDA, TAKASHI; OKABE, HIDETOSHI

2012-01-01

168

Non-Hodgkin lymphomas of Waldeyer's ring.  

PubMed

Lymphomas represent malignant lymphoproliferative diseases and they are generally classified as Hodgkin's (HL) or non-Hodgkin malignant lymphomas (NHML). Head and neck lymphomas represent one of the most common sites of extranodal lymphomas, second after the gastrointestinal tract. Waldeyer's ring structures include the palatine tonsils, the nasopharyngeal lymphatic tissue, and the lingual tonsil. We investigated 38 patients with malignant lymphoma with ages ranging from 21 to 95 years, all localized in the Waldeyer's ring. Good knowledge of the clinical characteristics of these lymphomas and the methods to establish the differential diagnosis are essential for a correct therapy of the disease. PMID:23303032

Salplahta, D; Com?nescu, Maria Victoria; Anghelina, F; Ioni??, Elena; Mogoant?, Carmen Aurelia; Anghelina, Liliana

2012-01-01

169

Langerhans Cell Histiocytosis Followed by Hodgkin's Lymphoma  

PubMed Central

A 22-year-old man was referred to our institution due to lower back pain and was diagnosed with Langerhans cell histiocytosis of the thoracic and lumbar spine. The patient achieved complete remission with radiotherapy and chemotherapy. One year later, right cervical lymphadenopathy was observed and Hodgkin's lymphoma was confirmed on biopsy. The patient was treated with chemotherapy and autologous stem cell transplantation, and experienced no further symptoms. Further, no evidence of recurrence was observed on follow-up imaging. This report discusses the association between Langerhans cell histiocytosis and Hodgkin's lymphoma.

Park, IK Soo; Park, In Keun; Kim, Eun Kyoung; Kim, Shin; Jeon, Sang Ryong; Huh, Joo Ryung

2012-01-01

170

Hydrocele following treatment for Hodgkin's disease  

SciTech Connect

Thirteen Hodgkin's disease patients developed hydrocele after treatment with radiotherapy (12 patients) or chemotherapy (one patient). An additional patient developed testicular swelling following radiotherapy and chemotherapy. Eleven of 13 patients were staged with laparotomy (nine initially, two at restaging) which included pelvic and aortic node biopsies prior to development of hydrocele. Five of the patients developed radiation-related pericarditis. These data suggest that staging and treatment of Hodgkin's disease may disrupt pelvic lymphatic flow and lead to hydrocele formation. The high incidence of treatment-related pericarditis may suggest unusual sensitivity to radiation in this group of patients.

Duffey, P.; Campbell, E.W.; Wiernik, P.H.

1982-07-15

171

The Internet Classics Archive  

NSDL National Science Digital Library

The Internet Classics Archive has recently been extensively updated and more than doubled in size. This premier classical literature resource now offers 375 works by 30 classical authors, in English translation. The complete body of work is attractively and logically formatted for easy and swift browsing. It is supported by a newly improved search engine. The Tech Classics Archive is a non-commercial, student-created World-Wide Web site that will be one year old in October.

1998-01-01

172

The incidence of non-Hodgkin's lymphoma and its histologic subtypes in Asian migrants to the United States and their descendants  

Microsoft Academic Search

We examined the incidence of non-Hodgkin's lymphoma (NHL) in Chinese, Japanese, and Filipino residents of the United States to obtain further clues about the etiology of the disease. The age, race, and birthplace of residents of Hawaii, San Francisco\\/Oakland (California), and western Washington who had received a diagnosis of NHL during the period 1973–86 were obtained from population-based cancer registries,

Lisa J. Herrinton; Marcia Goldoft; Stephen M. Schwartz; Noel S. Weiss

1996-01-01

173

The Classical Vacuum.  

ERIC Educational Resources Information Center

|The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Boyer, Timothy H.

1985-01-01

174

The Classical Vacuum.  

ERIC Educational Resources Information Center

The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Boyer, Timothy H.

1985-01-01

175

Pseudoautosomal Linkage of Hodgkin Disease  

PubMed Central

Summary Heritable factors appear to account for much of the risk for Hodgkin disease (HD). There is evidence for an HLA-linked gene, but other predisposing loci remain unaccounted for. The observation of a family coinheriting both HD and Leri-Weill dyschondrosteosis (LWD) suggests that a gene conferring risk for HD resides adjacent to the LWD locus. The gene responsible for LWD, SHOX, localizes to the short-arm pseudoautosomal region (PAR) of the X and Y chromosomes. A unique segregation pattern for PAR-linked genes has been predicted—that affected sibs will tend to be same sex. An excess of sex-concordant affected sib pairs with HD has been noted but has been attributed to an environmental etiology. These two observations—sex concordance in sib pairs with HD and cosegregation of HD and LWD—impelled a test of the hypothesis that there is a PAR-localized gene for HD. By first scoring recombinations dissociating sex from phenotype in individuals from pedigrees with LWD, we determined a male maximum recombination frequency (?max) of .405. This places SHOX near the short-arm telomeres of the sex chromosome and supports the prediction that PAR recombination is obligatory for spermatogenesis. By inferring recombinations between HD and sexual phenotype in sib pairs, we predict, for the postulated HD gene, a male ?max as high as .254, which places it in proximity to SHOX. Morton's nonparametric affected-sib-pair “?” model was used in the evaluation of linkage between HD and phenotypic sex and gave a LOD score of 2.41. Using this approach, we reevaluated evidence for HLA linkage in HD in haplotyped sib pairs and found a LOD score of 2.00. The resulting ? values indicate that the putative PAR- and HLA-linked loci account for 29% and 40%, respectively, of the heritability of HD in an American population.

Horwitz, Marshall; Wiernik2, Peter H.

1999-01-01

176

Chinese Geography through Chinese Cuisine  

ERIC Educational Resources Information Center

|China has the world's largest population, now over 1.3 billion, but its land area (much of it high mountains or desert) is about the same as that of the United States, which has less than one-fourth as many people. So Chinese farmers have learned to use every inch of their fertile land intensively. Pressure on the land has required extremely…

Lipman, Jonathan

2010-01-01

177

SEOM clinical guidelines for the treatment of Hodgkin’s lymphoma  

Microsoft Academic Search

Hodgkin’s lymphoma is a malignant disease with an incidence of 2.2 cases\\/100,000. The main goals of staging are to measure\\u000a the extent of disease and associated prognostic factors. Distinct recommendations were produced for initial work-up, first-line\\u000a therapy of early and advanced stage disease and treatment of relapsed or resistant patients.

Cristina Quero Blanco; Ramón García Arroyo; Mariano Provencio Pulla; Antonio Rueda Domínguez

2010-01-01

178

Classification and prognostic value of serum copper\\/zinc ratio in hodgkin’s disease  

Microsoft Academic Search

The serum copper and zinc levels were determined by atomic absorption spectrometry in 135 Hodgkin’s disease (HD) patients\\u000a and in 100 healthy controls. These values were used to explore the application value of the serum copper\\/zinc ratio in the\\u000a histologic classification and prognosis in this illness.\\u000a \\u000a The resuls show that serum copper and the copper\\/zinc ratio were higher and the

Cunzhi Han; Jiexian Jing; Xianwen Zhao; Jingang Guo; Suling Hou

2001-01-01

179

Linfomas não-Hodgkin e SIDA Non-Hodgkin's Lymphomas and AIDS  

Microsoft Academic Search

Non-Hodgkin's lymphoma occurs among all population groups at risk for HIV infection, in all age groups and in different countries, with similar epidemiologic and clinico-pathologic features. Clinical presentations may include systemic lymphoma, primary CNS lymphoma, and primary effusion lymphoma. Recent in- vestigations have led to the identification of a particular type of AIDS-related non-Hodgkin's lymphoma defined as plasmablastic lymphoma of

Marisa Silva

2003-01-01

180

Current Strategies and New Approaches in the Treatment of Hodgkin’s Lymphoma  

Microsoft Academic Search

As a result of continuous improvement in therapeutic options and their verification by large multicenter trials, Hodgkin’s lymphoma (HL) has become one of the best curable cancers in adults. Nowadays, about 80–90% of patients in all stages achieve long-term survival. Nevertheless, these good results are threatened by treatment-associated toxicities such as infertility, cardiopulmonary toxicity and secondary malignancies. It is therefore

Michael Fuchs; Volker Diehl; Daniel Re

2006-01-01

181

Pulmonary inflammatory myofibroblastic tumor after Hodgkin’s lymphoma and application of PET imaging  

Microsoft Academic Search

Inflammatory myofibroblastic tumor (IMT) is a rare tumor with a particular histological pattern of myofibroblasts and mixed\\u000a inflammatory infiltrate. IMT has been rarely described in association with malignancy. This case report is of a 16-year-old\\u000a male who had Hodgkin’s disease (stage IVA) and who after chemotherapy and radiotherapy developed IMT, 16 months post completion\\u000a of therapy. The IMT was in the

R. Howman-Giles; G. McCowage; N. Graf; J. Harvey

2008-01-01

182

Immunohistochemical detection of ZAP70 in 341 cases of non-Hodgkin and Hodgkin lymphoma  

Microsoft Academic Search

Using immunohistochemical methods, we evaluated zeta-associated protein (ZAP)-70 expression in 341 cases of non-Hodgkin and Hodgkin lymphoma. In B-cell NHL, ZAP-70 was positive in five of six (83%) precursor B-lymphoblastic lymphoma, 11 of 37 (30%) chronic lymphocytic leukemia\\/small lymphocytic lymphoma (CLL\\/SLL), five of 39 (13%) mantle cell lymphoma, one of 12 (8%) Burkitt lymphoma, and one of 12 (8%) nodal

Joan H Admirand; George Z Rassidakis; Lynne V Abruzzo; Jose R Valbuena; Dan Jones; L Jeffrey Medeiros

2004-01-01

183

State-of-the-art Issues in Hodgkin’s Lymphoma Survivorship  

Microsoft Academic Search

The prognosis of Hodgkin’s lymphoma (HL) has markedly improved as management strategies evolved. In the modern era, less than\\u000a 15% of patients with early-stage, non-bulky HL will relapse, and less than one third of those with advanced disease will relapse.\\u000a As therapy for HL intensified, and as disease-related outcomes improved, the impact of the late effects of therapy has become

Shrujal S. Baxi; Matthew J. Matasar

2010-01-01

184

Antigenic differentiation of classical swine fever viruses in China by monoclonal antibodies  

Microsoft Academic Search

The phylogenetic diversity of classical swine fever virus (CSFV) in China has been extensively studied previously, with the report of the classification of Chinese CSFVs into four subgroups within two of the established genotypes, but the antigenic differences amongst Chinese CSF viruses still remain unknown. To address this issue, 21 CSFV field strains isolated in China between 1996 and 2006

Yan Zhu; Zixue Shi; Trevor W. Drew; Qin Wang; Huaji Qiu; Huanchen Guo; Changchun Tu

2009-01-01

185

Potential benefits of therapeutic splenectomy for patients with Hodgkin's disease and non-Hodgkin's lymphomas  

SciTech Connect

Thirty-four patients with Hodgkin's disease and non-Hodgkin's lymphoma underwent therapeutic splenectomies to improve hematologic tolerance for chemotherapy. The mean age was 40 years; there were 16 males and 18 females. Fourteen had Hodgkin's disease, 19 had non-Hodgkin's lymphoma, and 1 had malignant histocytosis. Nineteen had palpable splenomegaly, 19 had marrow involvement and 20 had splenic involvement by lymphoma. The following data were analyzed before and after splenectomy: mean white blood cell count (WBC) and platelet count on planned first day of cycle, delay ratio of chemotherapy delivery and percent maximal dose rate. Thirteen patients had non-Hodgkin's lymphoma, splenomegaly and positive bone marrow and showed significant benefit in all of the aforementioned parameters. Of the patients with prior irradiation, only those who completed their radiation greater than six months prior to splenectomy showed benefit. Ten patients had Hodgkin's disease, negative bone marrow and no splenomegaly. This group showed significant improvement in mean platelet count but more limited benefit in delay ratio and percent maximal dose rate. Thus, selected patients with lymphoma who are experiencing delays in chemotherapy because of poor count tolerance may benefit from splenectomy.

Schreiber, D.P.; Jacobs, C.; Rosenberg, S.A.; Cox, R.S.; Hoppe, R.T.

1985-01-01

186

Aneuploidy in sperm of Hodgkin`s disease patients receiving NOVP chemotherapy  

SciTech Connect

Induction of genetic damage in germ cells of young patients receiving chemo- or radiotherapy for cancers with probable cure, such as Hodgkin`s disease, is cause for concern. These young patients may someday desire children, and germ cell alterations presenting as numerical chromosomal abnormalities in sperm may place their future offspring at risk. To address this concern, we measured aneuploidy in sperm from eight young Hodgkin`s disease patients: four pre-treatment, four during treatment, and three over a 45 month period following treatment with NOVP (Novantrone, Oncovin, Vinblastine and Prednisone). Patients ranged in stage of disease from IA-IIEB and none had received prior radiation or chemotherapy. Using multi-chromosome sperm FISH with repetitive sequence probes specific for chromosomes X, Y and 8, we found a significant 2-4 fold increase in particular numerical chromosomal abnormalities during treatment which were limited in persistence post-treatment. Additionally, pre-treatment Hodgkin`s disease patients showed elevations in some numerical chromosomal abnormalities when compared to a healthy reference group. In several men, the fraction of aneuploid sperm did not return to healthy reference group levels even after completion of therapy. These results show that elevated sperm aneuploidy occurs in germ cells of young cancer patients during chemotherapy and suggest caution to prevent conceptions during this period. The elevated sperm aneuploidy appears transient, but in some cases never returns to healthy reference group levels.

Robbins, W.A.; Cassel, M.J.; Wyrobek, A.J. [Lawrence Livermore National Lab., CA (United States)] [and others

1994-09-01

187

Chinese Popular Literature and the Child.  

ERIC Educational Resources Information Center

This book surveys the essential elements of both the written and the oral traditions that have contributed to the literary background of China's children. Chapter topics include (1) Chinese literature and its transmission from early times; (2) myths, legends, and symbolism; (3) traditional education and the classics; (4) storytellers, puppets, and…

Scott, Dorothea Hayward

188

Generalized classical mechanics  

NASA Astrophysics Data System (ADS)

Generalized classical mechanics has been introduced and developed as a classical counterpart of the fractional quantum mechanics. The Lagrangian of generalized classical mechanics has been introduced, and equation of motion has been obtained. Lagrange, Hamilton and Hamilton-Jacobi frameworks have been implemented. Oscillator model has been launched and solved in 1D case. A new equation for the period of oscillations of generalized classical oscillator has been found. The interplay between the energy dependency of the period of classical oscillations and the non-equidistant distribution of the energy levels for fractional quantum oscillator has been discussed. We discuss as well, the relationships between new equations of generalized classical mechanics and the well-known fundamental equations of classical mechanics.

Laskin, N.

2013-09-01

189

The potassium A-current, low firing rates and rebound excitation in Hodgkin-Huxley models  

Microsoft Academic Search

It is widely believed, following the work of Connor and Stevens (1971,J. Physiol. Lond.\\u000a 214, 31–53) that the ability to fire action potentials over a wide frequency range, especially down to very low rates, is due\\u000a to the transient, potassium A-current (I\\u000a A). Using a reduction of the classical Hodgkin-Huxley model, we study the effects ofI\\u000a A on steady firing

Maureen E. Rush; John Rinzel

1995-01-01

190

Late-onset cervicoscapular muscle atrophy and weakness after radiotherapy for Hodgkin disease: a case series.  

PubMed

Patients with cervical or mediastinal Hodgkin disease (HD) classically underwent chemotherapy plus extended-field radiation therapy. We report six patients who gradually developed severe atrophy and weakness of cervical paraspinal and shoulder girdle muscles 5-30 years after mantle irradiation for HD. Although clinical presentation was uniform, including a dropped head syndrome, electrophysiological and pathological findings were rather heterogeneous. Either neurogenic or myogenic processes may be involved and sometimes combined. We discuss the pathophysiological mechanisms underlying these cervicoscapular motor complications of mantle irradiation in HD. PMID:20019226

Furby, A; Béhin, A; Lefaucheur, J-P; Beauvais, K; Marcorelles, P; Mussini, J-M; Bassez, G; Créange, A; Eymard, B; Pénisson-Besnier, I

2010-01-01

191

Autoimmune hemolytic anemia and nodular lymphocyte-predominant hodgkin lymphoma: a rare association.  

PubMed

Autoimmune hemolytic anemia (AIHA) has been associated with chronic lymphocytic leukemia, non-Hodgkin lymphoma, and classical Hodgkin lymphoma, but to the best of our knowledge, the association of AIHA and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has not been reported previously. A 20-year-old woman presented with conjunctival jaundice, fever, asthenia, and hemoglobin 9.2?g/dL revealing IgG-mediated warm antibody AIHA. Computed tomography (CT) scan and positron-emission tomography (PET) scan showed mediastinal and axillary lymph nodes with increased [(18)F]-fluorodeoxyglucose uptake. A mediastinal lymph node was biopsied during mediastinoscopy, and NLPHL was diagnosed by an expert hematopathologist. The hemoglobin level declined to 4.6?g/dL. The treatment consisted of four 28-day cycles of R-ABVD (rituximab 375?mg/m(2) IV, adriamycin 25?mg/m(2) IV, bleomycin 10?mg/m(2) IV, vinblastine 6?mg/m(2) IV, and dacarbazine 375?mg/m(2) IV, each on days 1 and 15). Prednisone was progressively tapered over 10 weeks. After the first chemotherapy cycle, the hemoglobin level rose to 12?g/dL. After the four cycles, PET and CT scans showed complete remission (CR). At the last followup (4 years), AIHA and NLPHL were in sustained CR. PMID:23710384

Salmeron, Géraldine; Molina, Thierry Jo; Fieschi, Claire; Zagdanski, Anne-Marie; Brice, Pauline; Sibon, David

2013-04-28

192

Autoimmune Hemolytic Anemia and Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Rare Association  

PubMed Central

Autoimmune hemolytic anemia (AIHA) has been associated with chronic lymphocytic leukemia, non-Hodgkin lymphoma, and classical Hodgkin lymphoma, but to the best of our knowledge, the association of AIHA and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) has not been reported previously. A 20-year-old woman presented with conjunctival jaundice, fever, asthenia, and hemoglobin 9.2?g/dL revealing IgG-mediated warm antibody AIHA. Computed tomography (CT) scan and positron-emission tomography (PET) scan showed mediastinal and axillary lymph nodes with increased [18F]-fluorodeoxyglucose uptake. A mediastinal lymph node was biopsied during mediastinoscopy, and NLPHL was diagnosed by an expert hematopathologist. The hemoglobin level declined to 4.6?g/dL. The treatment consisted of four 28-day cycles of R-ABVD (rituximab 375?mg/m2 IV, adriamycin 25?mg/m2 IV, bleomycin 10?mg/m2 IV, vinblastine 6?mg/m2 IV, and dacarbazine 375?mg/m2 IV, each on days 1 and 15). Prednisone was progressively tapered over 10 weeks. After the first chemotherapy cycle, the hemoglobin level rose to 12?g/dL. After the four cycles, PET and CT scans showed complete remission (CR). At the last followup (4 years), AIHA and NLPHL were in sustained CR.

Salmeron, Geraldine; Molina, Thierry Jo; Fieschi, Claire; Zagdanski, Anne-Marie; Brice, Pauline

2013-01-01

193

Biology, clinical course and management of nodular lymphocyte-predominant hodgkin lymphoma.  

PubMed

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) differs in histological and clinical presentation from classical Hodgkin lymphoma (cHL). The typical morphologic signs of NLPHL are atypical "lymphocytic and histiocytic" (L&H) cells, which are surrounded by a non-neoplastic nodular background of small lymphocytes of B-cell origin. The NLPHL cells are positive for CD45, CD19, CD20, CD22 and CD79a, but lack expression of CD15 and CD30, the typical markers for cHL. NLPHL patients are predominantly of male gender with a median age of 37 years. Patients often present in early stages (63%) and rarely have B-symptoms (9%). Treatment of NLPHL patients using standard Hodgkin lymphoma (HL) protocols leads to complete remission (CR) in more than 95% of patients. Survival and freedom from treatment failure (FFTF) are worse in advanced-stage patients than in early-stage patients. Thus, patients in advanced and in early stages with unfavorable risk factors are treated similarly to cHL patients. In contrast, patients with early-stage NLPHL without risk factors can be sufficiently treated with reduced intensity programs having less severe adverse effects. As a result, treatment of early NLPHL is less clearly defined, including radiotherapy in extended field (EF) or involved field (IF) technique, combined modality treatment, and, more recently, monoclonal antibody rituximab. Watch and wait strategy plays an important role in pediatric oncology to avoid adverse effects associated with therapy. PMID:17124071

Nogová, Lucia; Rudiger, Thomas; Engert, Andreas

2006-01-01

194

Chinese Dinosaurs  

NSDL National Science Digital Library

What's "Jurassic Park" in Mandarin? That isn't easy to say, but if you're interested in Chinese dinosaurs, then you will love the new online (and real) exhibit hosted by the Australian Museum in Sydney. A vast land containing many of the world's best-preserved dinosaur specimens, China offers remnants of many species not commonly available in Western exhibits. With lots to explore, the site features a readily accessible list of dinosaurs, each arranged under its Chinese-derived species name. Not like anything most of us have ever heard, many of the specimens look and seem familiar, at least as members of the dinosaur family. While generally well-executed, particularly worthy of note is the site's presentation of China's celebrated feathered dinosaurs, Caudipteryx zoui and Protarchaeopteryx, two curious figures believed to represent part of the great reptilian leap from land to air.

2002-01-01

195

The results of radiotherapy for Hodgkin's disease  

Microsoft Academic Search

The results of radiation therapy in 212 patients with stages I and II Hodgkin's disease treated between 1963 and 1973 show that approximately 60% remain disease-free following treatment. Multiple node involvement in stage II, particularly associated with infraclavicular node disease, is identified as a group where the relapse rate is high. This presentation is associated particularly with NS. In a

M J Peckham; H T Ford; T J McElwain; C L Harmer; K Atkinson; D E Austin

1975-01-01

196

Hodgkin's disease involving the large bowel.  

PubMed

Hodgkin's disease (HD) is a malignancy that rarely affects the gastrointestinal tract. We describe a patient with disseminated, relapsed HD, in whom HD was found in a colorectal polyp. We also review the literature regarding HD involving the colon. To our knowledge, this is the first reported case of colonic HD presenting as a polyp. PMID:12450436

Zemsky, L; Katz, H; Edelman, M; Makower, D

2001-11-01

197

Non-hodgkin lymphomas of the thyroid  

Microsoft Academic Search

Twenty-nine cases of non-Hodgkin lymphomas presenting in the thyroid were classified according to Rappaport and Lukes and Collins. In the Rappaport classification there were 19 histiocytic, three mixed, five nodular PDL and two undifferentiated lymphomas. According to Lukes and Collins, 21 cases were follicular center cell lymphomas, eight were immunoblastic sarcomas. Cases classified as histiocytic according to Rappaport fell into

Robert Maurer; Clive R. Taylor; Roger Terry; Robert J. Lukes

1979-01-01

198

Unidirectional synchronization of Hodgkin–Huxley neurons  

Microsoft Academic Search

Synchronization dynamics of two noiseless Hodgkin–Huxley (HH) neurons under the action of feedback control is studied. The spiking patterns of the action potentials evoked by periodic external modulations attain synchronization states under the feedback action. Numerical simulations for the synchronization dynamics of regular–irregular desynchronized spiking sequences are displayed. The results are discussed in context of generalized synchronization. It is also

Octavio Cornejo-Pérez; Ricardo Femat

2005-01-01

199

Contamination of Hodgkin's Disease Cell Cultures.  

National Technical Information Service (NTIS)

Several laboratories have recently reported the establishment and characterization of long-term cell lines thought to be related to the neoplastic cell of Hodgkin's disease. Here, Harris, et al, discuss evidence that some of these lines are, in fact, not ...

N. L. Harris D. L. Gang S. C. Quay S. Poppema P. C. Zamecnik

1981-01-01

200

Chinese Counterspace Intentions.  

National Technical Information Service (NTIS)

This report details Chinese perceptions about space warfare and U.S. space policy. While China lacks a published space policy outlining the guiding principles of the Chinese space program, Chinese scholars and leaders make their opinions about space warfa...

H. Rademacher J. Cantone J. Cowin M. Caldararo R. Huggins

2008-01-01

201

Challenge of innovation to classic business management theories  

Microsoft Academic Search

Innovation is the most important source for enterprise to gain competitive advantage, and advanced innovation management is critical to an enterprise's sustainable development. Classic business management theory can't catch up with the dramatic changes of environment where enterprises exist. This paper first analyses the situation of innovation and innovation management of Chinese enterprises and the environment facing them, then integrates

Chen Jin; Wang Anquan

2001-01-01

202

What's New in Research and Treatment of Non-Hodgkin Lymphoma in Children?  

MedlinePLUS

... resources for non-Hodgkin lymphoma in children What`s new in research and treatment of non-Hodgkin lymphoma ... further treatment is not given. Clinical trials of new treatments Most children with non-Hodgkin lymphoma are ...

203

Supervaluationism and Classical Logic  

NASA Astrophysics Data System (ADS)

The supervaluationist theory of vagueness provides a notion of logical consequence that is akin to classical consequence. In the absence of a definitely operator, supervaluationist consequence coincides with classical consequence. In the presence of 'definitely', however, supervaluationist logic gives raise to counterexamples to classically valid patterns of inference. Foes of supervaluationism emphasize the last result to argue against the supervaluationist theory. This paper shows a way in which we might obtain systems of deduction adequate for supervaluationist consequence based on systems of deduction adequate for classical consequence. Deductions on the systems obtained this way adopt a completely classical form with the exception of a single step. The paper reviews (at least part of) the discussion on the non-classicality of supervaluationist logic under the light of this result.

Cobreros, Pablo

204

Non-Hodgkin's Lymphoma and Family History of Hematologic Malignancy  

Microsoft Academic Search

Familial aggregation of non-Hodgkin's lymphoma, and the co-occurrence of non-Hodgkin's lymphoma and other hematologic malignancies within families, provide evidence for genetic or common environmental etiologies for these conditions. The authors analyzed the association between non-Hodgkin's lymphoma risk and family history of hematologic malignancy using a case-control study based in the United Kingdom. The study recruited patients diagnosed with lymphoma during

F. K. Mensah; E. V. Willett; P. Ansell; P. J. Adamson; E. Roman

2007-01-01

205

A comparision of Hodgkin-Huxley and soliton neural theories  

NASA Astrophysics Data System (ADS)

Hodgkin and Huxley were the pioneers to abstract biological neuron as an electric circuit and nerve signal as the voltage impulse. The Hodgkin-Huxley theory (Hodgkin and Huxley, 1952) has set the direction and defined the goals for much of the ensuing research in biophysics. However, in 2005, T. Heimburg and A. D. Jackson, biophysicists from Copenhagen proposed a new neural theory called Soliton theory (Heimburg and Jackson, 2005). In this theory, the nerve conduction is proposed as a density wave. In this paper, Hodgkin-Huxley and Soliton theories are described and a theoretical comparison has been carried out throughout the analysis of the theories and models.

Appali, R.; Petersen, S.; van Rienen, U.

2010-09-01

206

Aberrant Expression of ID2, a Suppressor of B-Cell-Specific Gene Expression, in Hodgkin's Lymphoma  

PubMed Central

The global loss of B-cell-specific gene expression is a distinctive feature of the Hodgkin-Reed/Sternberg (HRS) cells of classical Hodgkin’s lymphoma (HL). The reasons for this loss remained largely unknown as transcription factors with pleiotropic effects on B-cell-specific gene expression, namely E2A, EBF, and PAX5, are present in primary HRS cells. We show here that ID2, which can inactivate E2A and perhaps PAX5, is not detectable in normal B cells but is strongly and uniformly expressed in HRS cells of all cases of classical HL. Recurrent chromosomal gains of the ID2 gene might contribute to this aberrant expression. Co-immunoprecipitation of E2A with ID2 from HRS-derived cell lines together with the high amount of ID2 relative to the B-cell transcription factors E2A and PAX5 in HRS-derived cell lines and primary HRS cells indicated that aberrant ID2 expression contributes significantly to the loss of the B-cell-specific gene expression in HRS cells. ID2 was also expressed in lymphocyte-predominance HL, mediastinal large B-cell, diffuse large B-cell, and Burkitt’s lymphoma, where lower amounts of ID2 relative to E2A and PAX5 compared with HRS cells might prevent a global down-regulation of B-cell-specific genes and ID2 may contribute to lymphomagenesis in other ways.

Renne, Christoph; Martin-Subero, Jose Ignacio; Eickernjager, Maren; Hansmann, Martin-Leo; Kuppers, Ralf; Siebert, Reiner; Brauninger, Andreas

2006-01-01

207

Classical Adiabatic Holonomy.  

National Technical Information Service (NTIS)

We briefly review the classical-adiabatic-holonomy effect known as Hannay's angle. We find, with purely classical methods, that the angle two-form connected with this phenomenon can be associated with a modification of the slow variable dynamics. We point...

E. Gozzi W. D. Thacker

1987-01-01

208

Noncommutative Classical Mechanics  

Microsoft Academic Search

In this work, I investigate the noncommutative Poisson algebra of classical observables corresponding to a proposed general noncommutative quantum mechanics, Djemai, A. E. F. and Smail, H. (2003). I treat some classical systems with various potentials and some physical interpretations are given concerning the presence of noncommutativity at large scales (celestial mechanics) directly tied to the one present at small

A. E. F. Djemai

2004-01-01

209

Fermions from classical statistics  

SciTech Connect

We describe fermions in terms of a classical statistical ensemble. The states {tau} of this ensemble are characterized by a sequence of values one or zero or a corresponding set of two-level observables. Every classical probability distribution can be associated to a quantum state for fermions. If the time evolution of the classical probabilities p{sub {tau}} amounts to a rotation of the wave function q{sub {tau}}(t)={+-}{radical}(p{sub {tau}}(t)), we infer the unitary time evolution of a quantum system of fermions according to a Schroedinger equation. We establish how such classical statistical ensembles can be mapped to Grassmann functional integrals. Quantum field theories for fermions arise for a suitable time evolution of classical probabilities for generalized Ising models.

Wetterich, C., E-mail: c.wetterich@thphys.uni-heidelberg.d [Institut fuer Theoretische Physik, Universitaet Heidelberg, Philosophenweg 16, D-69120 Heidelberg (Germany)

2010-12-15

210

The bcl -2\\/JH gene rearrangement is undetectable in Hodgkin's lymphomas: results from the German Hodgkin trial  

Microsoft Academic Search

Ninety-one Hodgkin's lymphomas (HD), 52 non-Hodgkin lymphomas (NHL) and 33 specimens of non-neoplastic lymphatic tissues were investigated by polymerase chain reaction (PCR) for the presence of the bcl-2\\/JH gene rearrangement. The majority of the HD cases were drawn from the files of the German Hodgkin trial where diagnoses are established by a panel of four independent histopathologists. Using the very

M. Nolte; M. Werner; R. Wasielewski; L. Wilkens; A. Georgii; W. Spann; B. Schnabel; K. Hübner; R. Fischer

1995-01-01

211

Abnormal immunoregulation in remission Hodgkin disease.  

PubMed

Peripheral blood mononuclear cells from 11 patients with remission Hodgkin disease and 20 normal controls were incubated with irradiated allogeneic lymphocytes in one-way mixed lymphocyte cultures. Simultaneously, modified assays were performed by adding supplemental irradiated PBM, T lymphocytes, or adherent cells autologous to the responders. Baseline allogeneic responsiveness of patients and controls was not different. However, significant suppression (p less than .01) was demonstrated when the cultures were supplemented with patient mononuclear cells or adherent cells, an effect not found with similar supplemental cells from controls. Conversely, T-cell supplementation of control cultures produced more than twofold increases in proliferation but significantly less augmentation in the patients' cultures (p less than .01). T-cell subset analysis in six patients showed decreased helper: suppressor cell ratios. Hodgkin disease patients have adherent suppressor cells, which persist during remission, as well as a defect in T-cell helper function. PMID:2931021

Hutchins, M R; Slease, R B; Murray, J L; Gawith, K E; Grozea, P N

1985-10-01

212

[Pulmonary Langerhans histiocytosis and Hodgkin's lymphoma].  

PubMed

Pulmonary Langerhans histiocytosis (PLH) is a rare disease due to the accumulation of Langerhans cells at the level of the bronchioles. These dendritic immunocytes form granulomata and destroy the wall of the airway. We report a case of PLH developing at the same time as Hodgkin's lymphoma in a young woman who smoked tobacco and cannabis. We observed a complete remission of the PLH lesions parallel to the remission of the Hodgkin's lymphoma after chemotherapy, in the absence of any change in the consumption of tobacco and cannabis. This observation leads us to discuss the potential relationships between PLH on one hand, and smoking, the lymphoma and its treatment on the other. PMID:21943541

Paris, A; Dib, M; Rousselet, M-C; Urban, T; Tazi, A; Gagnadoux, F

2011-07-30

213

Principles of Radiation Techniques in Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Radiation therapy (RT) is a major component of the current successful treatment of Hodgkin lymphoma (HL). For decades, radiation\\u000a was used alone to cure the majority of patients with HL; RT is still the most effective single agent in the the oncologic\\u000a armamentarium for this disease, and it remains the treatment of choice for patients with early-stage lymphocye predominance\\u000a HL

Joachim Yahalom; Richard T. Hoppe

214

Treatment of Early Favorable Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Most research groups define favorable early Hodgkin lymphoma (HL) as stage I–II disease without risk factors. The vast majority\\u000a of these patients can be cured with chemotherapy, radiotherapy, or with combined modality approaches. Before the introduction\\u000a of combined modality approaches, large-field radiotherapy had resulted in very good tumor control, but relapses occurred in\\u000a approximately 30% of patients, with most recurrences

Elly Lugtenburg; Anton Hagenbeek

215

Second cancers following non-Hodgkin's lymphoma  

Microsoft Academic Search

The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed\\/expected (O\\/E) = 1.18; O

Lois B. Travis; Rochelle E. Curtis; John D. Boice; Benjamin F. Hankey; Joseph F. Fraumeni

1991-01-01

216

Autologous stem cell transplantation in Hodgkin's disease  

Microsoft Academic Search

The majority of patients with Hodgkin's disease (HD) are curable with first-line therapy; however, 10-20% of patients with advanced HD will not enter complete remission (CR) with conventional first-line therapy and a further 20-30% will relapse after having initially achieved CR (1-3). New first line protocols such as BEACOPP (bleomycin, etoposide, doxo- rubicin, cyclophosphamide, vincristine, procarbazine and prednisone), used in

I. Avivi; A. H. Goldstone

217

Non-Hodgkin Lymphoma: Diagnosis and Treatment  

Microsoft Academic Search

Non-Hodgkin lymphomas are a heterogeneous group of malignan- cies of the lymphoid system. Based on the World Health Organiza- tion classification of hematological and lymphoid tumors, these diseases have been classified as B-cell and T-cell neoplasms. B- cell lymphomas account for approximately 90% of all lymphomas, and the 2 most common histological disease entities are follicular lymphoma and diffuse large

STEPHEN M. ANSELL; JAMES ARMITAGE

2005-01-01

218

Non-Hodgkin's lymphoma of the lung.  

PubMed

Non-Hodgkin's lymphoma (NHL) commonly presents with extensive disease involving extranodal tissues. Involvement of the mediastinal and hilar lymph nodes, pleura and lung parenchyma are recognised complications although their incidence is uncertain. However, pulmonary involvement is undoubtedly much less common than involvement at other extra nodal sites. Histologically proven NHL limited to the lung parenchyma, after full staging including computerised tomography and marrow trephines, is extremely rare. We report on two such cases and review the literature. PMID:3399878

Farquhar, D L; Crompton, G K; McIntyre, M A; Leonard, R C

1988-04-01

219

Thoracic Involvement in Non-Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Non-Hodgkin lymphoma (NHL) is known to involve multiple intra- and extrathoracic sites. Radiologic evidence of thoracic disease\\u000a occurs in 45–48% of patients with NHL (Castellino et al. 1996; Romano and Libshitz 1998); the frequency at autopsy is 73% (Vieta and Craver 1941). Although the most common manifestation of thoracic lymphoma is intrathoracic nodal involvement, it can occur at multiple\\u000a extranodal

Pamela J. Dipiro; Philip Costello

220

Non-Hodgkin Lymphomas of Mice  

Microsoft Academic Search

ABSTRACTStudies of lymphoid neoplasms occurring in normal or genetically engineered mice have revealed parallels and differences to non-Hodgkin lymphomas (NHL) of humans. Some mouse lymphomas have strong histologic similarities to the human NHL subsets including precursor B- and T-cell lymphoblastic, small lymphocytic, splenic marginal zone, and diffuse large-cell B-cell lymphomas (DLCL); whether molecular parallels also exist is under study. Others

Mitsuo Hori; Shao Xiang; Chen-Feng Qi; Sisir K. Chattopadhyay; Torgny N. Fredrickson; Janet W. Hartley; Alexander L. Kovalchuk; Georg W. Bornkamm; Siegfried Janz; Neal G. Copeland; Nancy A. Jenkins; Jerrold M. Ward; Herbert C. Morse

2001-01-01

221

Expression of Fas and Fas ligand in Hodgkin's disease.  

PubMed

Fas and Fas ligand expression were investigated in twenty two cases of classical Hodgkin's disease (HD) by immunohistochemistry. While Reed-Sternberg (RS) cells in 7/22 (32%) cases expressed Fas ligand, reactive lymphoid cells expressed Fas ligand in only 2 (9%) cases. In 20/22 (91%) cases, the RS cells expressed Fas. A higher proportion of RS cells in the nodular sclerosis subtype expressed Fas as compared to the mixed cellularity subtype. In 18/22 (82%) cases, Fas expression was also noted in the reactive lymphoid cells. In eight cases, the reactive lymphoid cells were also analyzed by flow cytometry and a majority of them were CD4+CD45RO+. Most of these activated T-cells expressed Fas but were negative for Fas Ligand. To investigate the co-expression of Fas and Fas Ligand in the RS cells, six cases were subjected to Fas and Fas ligand immunostaining on consecutive sections. The co-expression was documented in the RS cells in four of six cases. These six cases with expression of both Fas and Fas ligand were investigated for the incidence of apoptosis. There was no statistically significant relationship between expression of Fas on reactive cells, expression of FasL on RS cells and the proportion of apoptotic reactive cells. In all these cases apoptosis was not observed in the RS cells. Thus Fas - FasL interactions may not lead to apoptosis of the RS cells. PMID:10342579

Metkar, S S; Naresh, K N; Redkar, A A; Soman, C S; Advani, S H; Nadkarni, J J

1999-05-01

222

Treatment Outcome of Limited Stage Hodgkin's Disease  

PubMed Central

Purpose The 10-year overall survival rate following conventional treatments for patients with limited-stage Hodgkin's disease (HD) exceeds 90%. However, the clinical features and treatment outcome of HD in Korea have not been extensively characterized due to its low incidence. In this study, we attempted to analyze the treatment outcome of different modalities in limited stage HD patients. Materials and Methods Twenty one Hodgkin's disease patients, referred to the Samsung Medical Center between January 1997 and December 2003, were enrolled in this study. Limited stage Hodgkin's disease was subdivided into low and high risk groups. All evaluable patients received treatment. Results There were 13 and 8 patients in the low and high risk groups, respectively. Eighteen patients (86%) obtained complete response (CR) and 3 patients (14%) achieved an undetermined complete response (CRu). Fourteen (67%), 4 (19%) and 3 (14%) cases received combination chemotherapy, radiotherapy alone and chemotherapy alone, respectively. Four cases relapsed and 2 obtained a second CR. The 5-year overall and disease-free survival rates were 90 and 72%, respectively, for all patients. The median follow-up duration was 31 months. There was no difference in disease free survival (DFS) between the low and high risk groups. Although 12 cases had neutropenia greater than grade III, none experienced neutropenic fever. Conclusion The treatment outcome of limited-stage HD was excellent, regardless to the initial treatment modality.

Kang, Jung Hun; Ahn, Yong Chan; Kim, Won Seog

2005-01-01

223

The results of radiotherapy for Hodgkins' disease.  

PubMed

The results of radiation therapy in 212 patients with stages I and II Hodgkin's disease treated between 1963 and 1973 show that approximately 60% remain disease-free following treatment. Multiple node involvement in stage II, particularly associated with infraclavicular node disease, is identified as a group where the relapse rate is high. This presentation is associated particularly with NS. In a group of 78 patients treated with radiotherapy following staging laparotomy and splenectomy approximately 80% remain in complete remission. The preliminary results of treatment in PS IIIa patients are substantially the same as those for PS I and II; the results of treatment for NS and MC disease are similar. The significance of involvement of the spleen is discussed. Although it is probable that Hodgkin's disease spreads to the spleen through the blood stream it is suggested that splenic involvement does not necessarily indicate that the involvement of other extralymphatic structures such as liver and marrow has occurred. However, when the nodes in the porta hepatis are involved splenic Hodgkin's disease may well be associated with an increased risk of occult hepatic infiltration. PMID:1233084

Peckham, M J; Ford, H T; McElwain, T J; Harmer, C L; Atkinson, K; Austin, D E

1975-09-01

224

Development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease  

SciTech Connect

Three patients developed non-Hodgkin's lymphoma (NHL) 3 to 6 years after treatment for Hodgkin's disease (HD). In no instance was there evidence of recurrence of HD following the initial chemotherapy or radiotherapy. None of these patients had received both radiation therapy and chemotherapy. All patients responded well to conventional chemotherapy for NHL and are alive at 23 +, 37 +, and 65+ months after that secondary diagnosis. This report, when coupled with at least ten other such reported patients, suggests that NHL may be a relatively uncommon but significant complication of therapy for HD and must be distinguished for recurrence of HD.

Kim, H.D.; Bedetti, C.D.; Boggs, D.R.

1980-12-15

225

Postchemotherapy PET evaluation correlates with patient outcome in paediatric Hodgkin’s disease  

Microsoft Academic Search

Aim  To evaluate the role of postchemotherapy FDG PET and compare it with other predictive factors in paediatric Hodgkin’s disease\\u000a (HD).\\u000a \\u000a \\u000a \\u000a \\u000a Materials and methods  In this retrospective study, 98 paediatric patients with HD (enrolled in eight Italian centres) were analysed. Their mean\\u000a age was 13.8 years (range 5–19 years). A PET scan was performed at the end of chemotherapy and reported as positive or

Egesta Lopci; Roberta Burnelli; Luca Guerra; Angelina Cistaro; Arnoldo Piccardo; Pietro Zucchetta; Enrico Derenzini; Alessandra Todesco; Alberto Garaventa; Fabio Schumacher; Piero Farruggia; Salvatore Buffardi; Alessandra Sala; Fiorina Casale; Paolo Indolfi; Samanta Biondi; Andrea Pession; Stefano Fanti

226

Classical Atomic Form Factor  

NASA Astrophysics Data System (ADS)

The general trends exhibited in the variation of the inelastic form factor in collisional transitions nl-->n'l', when l' is changed and n, l, and n' are kept fixed, are explained solely in terms of classical mechanics. Previous quantal results are reproduced from purely classical mechanics principles. Our conclusions are valid not only for large quantum numbers (which provide the usual classical correspondence) but also for other cases, which, up to now have been described only by quantal or semiclassical methods. The interesting trends exhibited in the form factor are directly reflected in experimental and theoretical treatments of collisions involving excited atoms.

Vrinceanu, D.; Flannery, M. R.

1999-04-01

227

Classical Mythology Directory  

NSDL National Science Digital Library

Created by Dr. Robin Mitchell-Boyask, Professor in the Department of Greek, Hebrew, and Roman Classics at Temple University, this site is primarily intended for students enrolled in the Dr. Mitchell-Boyask's summer or fall 2002 Classical Mythology course. However, the site provides a host of information on classical mythology and would be useful to anyone studying and/or interested in this area of specialization. Not only does the site contain study guides, which could be valuable material for English teachers, but it also contains information on the myths of Rome and Athens, numerous paintings and sculptures, as well as many links to other relevant sites.

Mitchell-Boyask, Robin, 1961-.

1998-01-01

228

GR Classical Exploding Program  

NSDL National Science Digital Library

The GR Classical Exploding program uses Newtonian mechanics to simulate the orbits of objects that explode near a central massive object. It also shows the effective potential of the orbiting particle. The default configuration is an explosion located at r = 1. GR Classical Exploding is part of a suite of Open Source Physics programs that model aspects of General Relativity. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the gr_classical_exploding.jar file will run the program if Java is installed. Other programs provide additional visualizations. They can be found by searching ComPADRE for Open Source Physics, OSP, or General Relativity.

Christian, Wolfgang; Belloni, Mario; Cox, Anne

2008-05-27

229

Classical Helium Model  

NSDL National Science Digital Library

The EJS Classical Helium Model is an example of a three-body problem that is similar to the gravitational three-body problem of a heavy sun and two light planets. The important difference is that the helium atom's two electrons repel one another, unlike the planetary case where the intraplanetary interaction is attractive. The EJS Classical Helium Model was created using the Easy Java Simulations (Ejs) modeling tool. It is distributed as a ready-to-run (compiled) Java archive. Double clicking the ejs_mech_orbits_ClassicalHelium.jar file will run the program if Java is installed.

Christian, Wolfgang

2009-03-14

230

Hasbun Classical Mechanics Package  

NSDL National Science Digital Library

The Hasbun Classical Mechanics Package is a self-contained Java package of OSP programs in support of the textbook: Classical Mechanics with MATLAB Applications. Classical Mechanics with MATLAB Applications is a resource for the advanced undergraduate taking introduction to classical mechanics. Filled with comprehensive examples and thorough descriptions, this text guides students through the complex topics of rigid body motion, moving coordinate systems, Lagrange's equations, small vibrations, the Euler algorithm, and much more. Step-by-step illustrations, examples and computational physics tools further enhance learning and understanding by demonstrating accessible ways of obtaining mathematical solutions. In addition to the numerous examples throughout, each chapter contains a section of MATLAB code to introduce the topic of programming scripts and their modification for the reproduction of graphs and simulations.

Hasbun, Javier

2008-06-23

231

A Classical Science Transformed.  

ERIC Educational Resources Information Center

Describes how satellites and other tools of space technology have transformed classical geodesy into the science of space geodynamics. The establishment and the activities of the French Center for Geodynamic and Astronomical Research Studies (CERGA) are also included. (HM)

Kovalevsky, Jean

1979-01-01

232

Spotlight on Confucius: Chinese Classics and Cultural Values. Updated.  

ERIC Educational Resources Information Center

This updated set of lesson plans focuses on Confucius and Confucian thought, especially Confucian ethics. The lesson plans are divided into the following chapters: (1) "How do the Analects embody the ethical framework of Confucian thought?"; (2) "How does Confucianism affect behavior, attitudes and beliefs?"; (3) "How did other belief systems…

Arkin, Linda, Ed.

233

Value of PET\\/CT versus PET and CT performed as separate investigations in patients with Hodgkin’s disease and non-Hodgkin’s lymphoma  

Microsoft Academic Search

Purpose  The aim of this study was to assess the clinical benefit of combined [18F]FDG PET\\/CT in patients with malignant lymphoma as compared to separately performed PET and CT.\\u000a \\u000a \\u000a \\u000a Methods  Overall, 100 patients with Hodgkin’s disease (HD) or non-Hodgkin’s lymphoma (NHL) were included in this study. Co-registered\\u000a PET\\/CT with [18F]FDG and contrast medium was performed in 50 consecutive patients with NHL (n=38)

Christian la Fougère; Walter Hundt; Nicole Bröckel; Thomas Pfluger; Alexander Haug; Bernhard Scher; Marcus Hacker; Klaus Hahn; Maximilan Reiser; Reinhold Tiling

2006-01-01

234

Isolated Bone Marrow Manifestation of HIV-Associated Hodgkin Lymphoma  

Microsoft Academic Search

Human immunodeficiency virus-associated Hodgkin lymphoma frequently involves the bone marrow and is usually recognized at staging after Hodgkin lymphoma diagnosis on a lymph node or other tissue biopsies, but occasionally the marrow involvement is the only apparent manifestation of disease. In the latter setting, diagnosis can be problematic. From a total of 42 patients with newly diagnosed human immunodeficiency virus–associated

Maurilio Ponzoni; Luca Fumagalli; Giuseppe Rossi; Massimo Freschi; Alessandro Re; Maria Grazia Viganò; Massimo Guidoboni; Riccardo Dolcetti; Robert W. McKenna; Fabio Facchetti

2002-01-01

235

Primary non-Hodgkin's lymphomas of the CNS  

Microsoft Academic Search

Background. Primary non-Hodgkin's lymphoma of the lung is a rare entity. Although the prognosis is favorable, clinical features, prognostic factors, and patient manage- ment have not been clearly defined. Methods. We reviewed retrospectively the records of 48 patients operated on for primary pulmonary non- Hodgkin's lymphoma. The study group consisted of 21 male (44%) and 27 female (56%) patients with

U. Bogdahn; S. Bogdahn; H. G. Mertens; D. Dommasch; R. Wodarz; P. H. Wünsch; P. Kühl; E. Richter

1986-01-01

236

Mammary carcinoma developing after radiotherapy and chemotherapy for Hodgkin's disease  

SciTech Connect

Two patients developed breast cancer after treatment of Hodgkin's disease. Both had received mediastinal irradiation 13 to 15 years, respectively, before the diagnosis of breast carcinoma. One patient had synchronous bilateral breast cancer when the diagnosis was made. Discussed is the risk of mammary carcinoma as a second malignant neoplasm in patients treated for Hodgkin's disease.

Janjan, N.A.; Wilson, J.F.; Gillin, M.; Anderson, T.; Greenberg, M.; Schewe, K.; Cox, J.D.

1988-01-15

237

[Analysis on dosage of traditional Chinese medicine decoction pieces stipulated in Chinese pharmacopoeia].  

PubMed

Chinese Pharmacopoeia I (2010 edition) covers dosage and usage of traditional Chinese medicinal herbs and decoction pieces, and provides dosage ranges of most of decoction pieces. By using the descriptive statistical method, the article discusses the distribution of maximum dosage, minimum dosage and dosage range of decoction pieces set forth in Chinese Pharmacopoeia, and compares toxic drugs and non-toxic drugs. Altogether 617 drugs are included into the study. Except for 16 decoction pieces whose dosages are not clear, all of the remaining decoction pieces are covered by Chinese Pharmacopoeia, with the maximum common dosage, minimum common dosage and dosage range of 3, 10 and 6 g. Upon comparison, we discovered that Chinese Pharmacopoeia sets stricter standards for toxic drugs than non-toxic drugs. Compared with dosages in classical prescriptions and actual clinical usages, dosage ranges described in Chinese Pharmacopoeia are much narrower. There is no significant difference between drugs that can be used as foods or healthcare foods and other drugs according to Chinese Pharmacopoeia. PMID:23847966

Ji, Hang-Yu; Chen, Xin-Yan; Jiao, Yong-Zheng; Tong, Xiao-Lin

2013-04-01

238

The Hodgkin-Huxley Heritage: From Channels to Circuits  

PubMed Central

The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin’s and Huxley’s ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost.

Catterall, William A.; Raman, Indira M.; Robinson, Hugh P. C.; Sejnowski, Terrence J.; Paulsen, Ole

2012-01-01

239

KLHDC8B in Hodgkin lymphoma and possibly twinning  

PubMed Central

A key feature of Hodgkin lymphoma is that the malignant cells are binucleated, as a consequence of failed cytokinesis. We recently ascertained a family in which multiple cases of Hodgkin lymphoma had occurred among individuals who inherited a balanced chromosomal translocation. We cloned the translocation breakpoints and found that it disrupted a previously uncharacterized gene, KLHDC8B, encoding a Kelch family protein whose deficiency impairs cytokinesis and leads to binucleated cells. In other families we found a rare single nucleotide polymorphism affecting mitotic translation of KLHDC8B that was associated with and linked to Hodgkin lymphoma. Interestingly, the index family demonstrated an unusual frequency of twins, and there is a previously reported association between Hodgkin lymphoma and twins. Here we review the unusual genetic features of Hodgkin lymphoma, including gender concordance among siblings, and genetically test the hypothesis that KLHDC8B may participate in twinning by disrupting cytokinesis through impediment of polar body separation from oocytes.

Timms, Andrew E

2010-01-01

240

Sun Exposure, Vitamin D, and Risk of Hodgkin and Non-Hodgkin Lymphoma  

Microsoft Academic Search

Similarities in the epidemiology of melanoma, other skin cancers, and non-Hodgkin lymphoma (NHL) have led to the hypothesis that UV exposure, the major risk factor for cutaneous cancers, could play a role on NHL risk too. Epidemiologic studies, however, including a pooled analysis of 10 case-control studies performed by the Interlymph consortium, have failed to confirm this hypothesis. If anything,

Eva Negri

2010-01-01

241

Prognostic factors and treatment outcome in primary progressive Hodgkin lymphoma: a report from the German Hodgkin Lymphoma Study Group  

Microsoft Academic Search

To determine prognostic factors and treat- ment outcome, patients with primary pro- gressive Hodgkin lymphoma (HD) regis- tered in the database of the German Hodgkin Lymphoma Study Group (GHSG) were analyzed retrospectively. Detailed records from randomized prospective multicenter trials performed between 1988 and 1998 of 3807 patients recruited in these trials were reviewed. The median age of the 206 patients

Andreas Josting; Ulrich Rueffer; Jeremy Franklin; Markus Sieber; Volker Diehl; Andreas Engert

2000-01-01

242

High expression of several tyrosine kinases and activation of the PI3K\\/AKT pathway in mediastinal large B cell lymphoma reveals further similarities to Hodgkin lymphoma  

Microsoft Academic Search

Mediastinal large B-cell (MBL) and classical Hodgkin lymphoma (HL) have several pathogenic mechanisms in common. As we recently observed aberrant tyrosine kinase (TK) activities in HL, we now analysed also MBL for such activities. Indeed, MBL and HL were the only B-cell lymphomas where elevated cellular phospho-tyrosine contents were typical features. Three TKs, JAK2, RON and TIE1, not expressed in

C Renné; K Willenbrock; J I Martin-Subero; N Hinsch; C Döring; E Tiacci; W Klapper; P Möller; R Küppers; M-L Hansmann; R Siebert; A Bräuninger

2007-01-01

243

Quantitative analysis of non-Hodgkin's lymphoma.  

PubMed Central

A preliminary attempt has been made to characterise a small series of non-Hodgkin's lymphomas (NHL) by morphometric means using the Quantimet 720 Kontron MOP/AMO3 image analysis systems. In most cases it was found that the distribution of nuclear area and correlation between mean nuclear area and frequency per unit field, corresponded closely with tumour classification determined by light microscopy. These results suggest that it may be possible to devise an objective and reproducible grading system for NHL using quantitative morphometric techniques.

Abbott, C R; Blewitt, R W; Bird, C C

1982-01-01

244

Non-Hodgkin lymphoma mimics retroperitoneal fibrosis.  

PubMed

A 33-year-old man presented with lymphoedema and obstructive nephropathy and was first diagnosed as retroperitoneal fibrosis (RF) with consistent clinical picture and radiographic findings. Further CT-guided biopsy was performed and non-Hodgkin lymphoma was diagnosed based on pathological results. RF is usually diagnosed through clinical presentation and imaging studies. However, our case proved that biopsy should be considered to exclude malignancy, even with typical presentations of RF. Follow-up after six courses of R-CHOP (rituximab, cyclophosphamide, vindesine, epirubicin and prednisone) regimen revealed complete resolution of symptoms. PMID:23921690

Wan, Ningxin; Jiao, Yang

2013-08-06

245

Adrenal involvement in non-Hodgkin lymphoma  

SciTech Connect

Adrenal masses are described in seven cases of non-Hodgkin lymphoma in a series of 173 patients. In all seven patients the lymphoma was diffuse rather than nodular. Three patients had adrenal masses at the time of presentation, whereas in four cases the adrenal gland was a site of tumor recurrence after therapy. Three patients had simultaneous bilateral adrenal involvement by tumor. No characteristic features were recognized that might have distinguished these tumors from other adrenal masses. Appropriate therapy successfully resolved the adrenal masses in all but one case. The latter patient was the only one with evidence of adrenal insufficiency.

Paling, M.R.; Williamson, B.R.J.

1983-08-01

246

Prognostic factors in pediatric Hodgkin disease.  

PubMed

The sensitivity of pediatric Hodgkin disease to radiation and chemotherapy has resulted in cure for most children and adolescents who have been diagnosed in the past three decades. Identification of prognostic factors in clinical trials has allowed for tailoring of therapeutic approaches to improve outcome in sequential trials. Tumor burden, symptoms, clinical features, pathology, response to therapy, biology, and host factors are reviewed in this context. New developments should be directed toward identification of factors associated with biologic mechanisms of disease to facilitate the development of biologically targeted therapies that will be more efficacious and less toxic. PMID:14521809

Schwartz, Cindy L

2003-11-01

247

Pathology Case Study: History of Hodgkin's Disease  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 37-year-old man, previously diagnosed with stage III nodular sclerosing Hodgkin's Disease has recently had a brief episode of syncope. Visitors are given the gross descriptions and radiology, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in neuropathology.

Brown, Henry G.; Whiting, Donald M.; Prostko, E. R.; Fox, Karl R.; Zhang, Jin

2009-04-01

248

Allogeneic Transplantation for Relapsed Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Hodgkin lymphoma (HL) is highly responsive to conventional chemotherapy (CT). Close to 90% of patients even with advanced\\u000a disease are cured with modern CT sometimes followed by irradiation (J Clin Oncol. 20:630–7, 2002; N Engl J Med. 348:2386–95,\\u000a 2003). Patients who prove refractory to or relapse after first-line therapy do significantly worse. High-dose therapy (HDT)\\u000a followed by autologous stem cell

Anna Sureda; Stephen Mackinnon

249

PRC's Overseas Chinese Policy.  

National Technical Information Service (NTIS)

This thesis examines the People's Republic of China's (PRC) overseas Chinese policy from its founding to the present. Over time China's overseas Chinese policy has evolved to reflect changing migration patterns and favorable international conditions. The ...

S. H. Zerba

2008-01-01

250

Noncommutative classical invariant theory  

NASA Astrophysics Data System (ADS)

In this thesis, we consider some aspects of noncommutative classical invariant theory, i.e., noncommutative invariants of the classical group SL(2, k). We develop a symbolic method for invariants and covariants, and we use the method to compute some invariant algebras. The subspace ? {d/m} of the noncommutative invariant algebra ? d consisting of homogeneous elements of degree m has the structure of a module over the symmetric group S m . We find the explicit decomposition into irreducible modules. As a consequence, we obtain the Hilbert series of the commutative classical invariant algebras. The Cayley—Sylvester theorem and the Hermite reciprocity law are studied in some detail. We consider a new power series H( ? d, t) whose coefficients are the number of irreducible S m -modules in the decomposition of ? {d/m}, and show that it is rational. Finally, we develop some analogues of all this for covariants.

Tambour, Torbjörn

1991-12-01

251

Classical New England  

NSDL National Science Digital Library

Classical New England is a public service provided by WGBH in Boston with affiliate stations in Nantucket and Providence, Rhode Island. The cornucopia of music here can be explored via the Topics section on the right-hand side of the page. Here visitors can look through programs like "The Bach Hour" and "Classical Music With Cathy Fuller." Not surprisingly, there's an entire section dedicated to Tanglewood, which is the summer home of the Boston Symphony Orchestra (BSO) in western Massachusetts. One notable feature here is the last interview with celebrated music director and conductor Erich Leinsdorf, in which he ruminates on his time working with the BSO. Additionally, users can look over the Most Popular list to learn about what other classical music fans are enjoying. Finally, the site also includes videos of various performances from around New England and beyond.

2012-09-07

252

Classics Technology Center  

NSDL National Science Digital Library

The Perseus Project at Tufts University (discussed in the October 17, 1997 Scout Report) is an ongoing initiative to create a comprehensive, interactive, multimedia digital library for the study of Archaic and Classical Greece. The Classics Technology Center, provided by Able Media, offers a collection of free materials to help educators and students make the most of Perseus. Provided in .pdf format, these include instructions for each Perseus component, tips and tricks, curriculum guides, teachers's companions, and a showcase of published works from students and educators around the world.

253

Computation in classical mechanics  

NASA Astrophysics Data System (ADS)

One way to introduce computation into the physics curriculum is to include it in a standard upper-level physics course. A course in intermediate classical mechanics is well-suited for this purpose. We discuss our approach and examples of student projects on solving differential equations and Liouville's theorem, projectile motion on a rotating Earth, motion of a charged particle in electric and magnetic fields, and approximate analytical and numerical solutions for a classical model of a molecule. The projects introduce students to these physics topics and develop the students' computational skills.

Timberlake, Todd; Hasbun, Javier E.

2008-04-01

254

3D Guqin: Digital Playground to Explore Music that Embodies Chinese Culture and Philosophy  

Microsoft Academic Search

This media art installation aims to digitally reconstruct a traditional Chinese Guqin string instrument using physical sensing techniques, to invite bodily interpretation of the classical instrument. Guqin has a unique place in the Chinese history, as a symbol of the high culture of the nobles and intellectuals (Junzi, Superior Man). It's also seen as the vessel for pursuing harmony. Guqin

Eng Tat Khoo; Roshan Lalintha Peiris; Matthias Rauterberg

2011-01-01

255

Chinese Tourists and Confucianism  

Microsoft Academic Search

Despite the widespread belief in the significance of Confucianism on the behaviour of Mainland Chinese people, limited empirical studies have been conducted to examine the Chinese cultural and philosophical ideology in a tourism context. As an exploratory attempt, this paper investigates the influence of Confucian values on Mainland Chinese corporate travellers at leisure on the Gold Coast, Australia. Based on

Anna Kwek; Young-Sook Lee

2010-01-01

256

Chinese Folktales for Children.  

ERIC Educational Resources Information Center

This bilingual text contains ten traditional Chinese folktales which have been rewritten for children. Each story deals with interpersonal relationships and/or stresses the Chinese way of life. Each page of text is given first in English and then in Chinese and is illustrated with a full-page drawing. The titles of the folktales are: (1) "One…

Kwok, Irene

257

Acoustical study of classical Peking Opera singing.  

PubMed

Acoustic characteristics of classical opera singing differ considerably between the Western and the Chinese cultures. Singers in the classical Peking opera tradition specialize on one out of a limited number of standard roles. Audio and electroglottograph signals were recorded for four performers of the Old Man role and three performers of the Colorful Face role. Recordings were made of the singers' speech and when they sang recitatives and songs from their roles. Sound pressure level, fundamental frequency, and spectrum characteristics were analyzed. Histograms showing the distribution of fundamental frequency showed marked peaks for the songs, suggesting a scale tone structure. Some of the intervals between these peaks were similar to those used in Western music. Vibrato rate was about 3.5Hz, that is, considerably slower than in Western classical singing. Spectra of vibrato-free tones contained unbroken series of harmonic partials sometimes reaching up to 17 000Hz. Long-term-average spectrum (LTAS) curves showed no trace of a singer's formant cluster. However, the Colorful Face role singers' LTAS showed a marked peak near 3300Hz, somewhat similar to that found in Western pop music singers. The mean LTAS spectrum slope between 700 and 6000Hz decreased by about 0.2dB/octave per dB of equivalent sound level. PMID:21621380

Sundberg, Johan; Gu, Lide; Huang, Qiang; Huang, Ping

2011-05-28

258

Differentiation of classical music requires little learning but rhythm  

Microsoft Academic Search

Detecting distinctions between the styles of classical music (e.g. Baroque and Romantic) is often viewed as the privilege of musicians. However, this elite perspective underestimates the abilities of non-musicians. We report that Western musicians and non-musicians, and non-Westerners (i.e. Chinese participants) rated pairs of excerpts presented auditorily as more similar as their compositional styles were closer in history. Moreover, the

Simone Dalla Bella; Isabelle Peretz

2005-01-01

259

Effective classical partition functions  

SciTech Connect

We present a method by which a quantum-mechanical partition function can be approximated from below by an effective classical partition function. The associated potential is obtained by a simple smearing procedure. For a strongly anharmonic oscillator and a double-well potential, the lowest approximation gives a free energy which is accurate to a few percent, even at zero temperature.

Feynman, R.P.; Kleinert, H.

1986-12-01

260

Classical galactosaemia revisited.  

PubMed

Classical galactosaemia (McKusick 230400) is an: autosomal recessive disorder of galactose metabolism, caused by a deficiency of the enzyme galactose-1-phosphate uridyltransferase (GALT; EC 2.7.712). Most patients present in the neonatal period, after ingestion of galactose, with jaundice, hepatosplenomegaly, hepatocellular insufficiency, food intolerance, hypoglycaemia, renal tubular dysfunction, muscle hypotonia, sepsis and cataract. The gold standard for diagnosis of classical galactosaemia is measurement of GALT activity in erythrocytes. Gas-chromatographic determination of urinary sugars and sugar alcohols demonstrates elevated concentrations of galactose and galactitol. The only therapy for patients with classical galactosaemia is a galactose-restricted diet, and initially all galactose must be removed from the diet as soon as the diagnosis is suspected. After the neonatal period, a lactose-free diet is advised in most countries, without restriction of galactose-containing fruit and vegetables. In spite of the strict diet, long-term complications such as retarded mental development, verbal dyspraxia, motor abnormalities and hypergonadotrophic hypogonadism are frequently seen in patients with classical galactosaemia. It has been suggested that these complications may result from endogenous galactose synthesis or from abnormal galactosylation. Novel therapeutic strategies, aiming at the prevention of galactose 1-phosphate production, should be developed. In the meantime, the follow-up protocol for patients with GALT deficiency should focus on early detection, evaluation and, if possible, early intervention in problems of motor, speech and cognitive development. PMID:16838075

Bosch, Annet M

2006-07-11

261

Classics in What Sense?  

ERIC Educational Resources Information Center

|They seem the perfect bookends for the social psychologist's collection of "classics" of the field. Two volumes, nearly identical in shape and weight and exactly a century old in 2008--each professing to usher "social psychology" into the world as they both place the hybrid expression square in their titles but then proceed to stake out the field…

Camic, Charles

2008-01-01

262

Classicism and Romanticism.  

ERIC Educational Resources Information Center

Describes one teacher's methods for introducing to secondary English students the concepts of Classicism and Romanticism in relation to pictures of gardens, architecture, music, and literary works. Outlines how the unit leads to a writing assignment based on collected responses over time. (HB)

Huddleston, Gregory H.

1993-01-01

263

Teach the Classics.  

ERIC Educational Resources Information Center

Addresses the question of what graduate students should know about fields of English in which they are not specializing. Finds the best answer is to teach "the classics." Illustrates with the example of a course on "The Faerie Queene" and "Paradise Lost," to show students how to work with texts and what can be discovered in them. (PA)

Alpers, Paul

1997-01-01

264

Diagnosis of classical galactosaemia.  

PubMed Central

We report a child with classical galactosaemia whose diagnosis was missed until 12 weeks of age. The limitations of urine screening tests are discussed and the wider use of a qualitative enzyme assay for screening is recommended. Reference ranges for a quantitative enzyme assay using 14galacoste-1-phosphate as substrate are presented.

Monk, A M; Mitchell, A J; Milligan, D W; Holton, J B

1977-01-01

265

The Classical Cake Problem  

ERIC Educational Resources Information Center

|Discussed are techniques of presentation and solution of the Classical Cake Problem. A frosted cake with a square base is to be cut into n pieces with the volume of cake and frosting the same for each piece. Needed are minimal geometric concepts and the formula for the volume of a prism. (JP)|

Nelson, Norman N.; Fisch, Forest N.

1973-01-01

266

Introducing Classics to Undergraduates  

ERIC Educational Resources Information Center

|University students in India generally dislike reading English classics, but some students well prepared in advance enjoyed Dickens'"Tale of Two Cities." They first read an illustrated comic book version, then read a dramatized version while listening to a recording, and then read an abridged version before reading the original. (CFM)|

Kumar, Sarat

1978-01-01

267

The Classical spring poem  

Microsoft Academic Search

Despite the existence of valuable commentaries on some Classical spring poems, this area of study has been insufficiently explored. After providing a definition and a schema of the spring poem as such, this dissertation investigates, through the detailed analysis of the specific spring poems (Catullus 46; Horace Odes 1. 4, 4. 7, 4. 12; Palatine Anthology 9. 363, 10. 1,

Dorin Garofeanu

2008-01-01

268

Classical Demonstration of Polarization.  

ERIC Educational Resources Information Center

Presents a classical demonstration of polarization for high school students. The initial state of this model, which demonstrates the important concepts of the optical and quantum problems, was developed during the 1973 summer program on lecture demonstration at the U.S. Naval Academy. (HM)

Bauman, Robert P.; Moore, Dennis R.

1980-01-01

269

Careers in the Classics  

ERIC Educational Resources Information Center

|America's few Black classics professors have overcome contempt and criticism to contribute a unique perspective to the study of the ancient world. Dr. Patrice Rankine, an associate professor from Purdue University, has grown used to the irony. As one of the few Black classicists teaching at an American university, he has drawn plenty of…

Lum, Lydia

2005-01-01

270

The Classics as Humanities  

ERIC Educational Resources Information Center

Classics may be taught as humanities to help students understand both the ancient and modern worlds. Literature taught in translation can acquaint students with these works and illuminate modern literature. Visual aids such as slides, photos, post cards, sculpture reproductions and maps may awaken student interest. (CK)

Norton, Mary E.

1975-01-01

271

Hodgkin's disease: prognostic factors and short-course regimens.  

PubMed

Both topics discussed in this review, prognostic factors and short-course regimens for Hodgkin's disease, have been the focus of recent research with the goal of developing tools and treatments that will result in the highest cure rates with the least long-term sequelae. A new "prognostic score" for advanced-stage Hodgkin's disease and several potential prognostic factors, including soluble CD30, soluble interleukin-2 receptor, activated cytotoxic T-lymphocytes, and Epstein-Barr virus, are discussed. Preliminary reports of short-course chemotherapy regimens with and without radiotherapy for all stages of Hodgkin's disease are summarized. PMID:11122839

Bartlett, N L; Arackal, S M

2000-03-01

272

Characterization of the Interleukin-1?-Converting Enzyme/Ced-3-Family Protease, Caspase-3/CPP32, in Hodgkin's Disease  

PubMed Central

Apoptosis (programmed cell death) serves an important role in the normal morphogenesis, immunoregulation, and homeostatic mechanisms in both normal and neoplastic cells. Caspase-3/CPP32, a member of the ICE/Ced-3-family of cysteine proteases, is an important downstream mediator of several complex proteolytic cascades that result in apoptosis in both hematopoietic and nonhematopoietic cells. Previous studies have demonstrated that caspase-3 is commonly expressed in classical Hodgkin’s disease (CHD); however, the biological significance of its expression in Hodgkin’s disease is unknown. In this report, the expression of caspase-3 in nodular lymphocyte predominance Hodgkin’s disease (NLPHD) was evaluated by immunohistochemistry; in addition, we investigated the role of caspase-3 in CD95 (Fas)-mediated apoptosis in three CHD cell lines. Formalin-fixed, paraffin-embedded tissue sections from 11 cases of NLPHD were immunostained for caspase-3 using a polyclonal rabbit antibody that detects both the 32-kd zymogen and the 20-kd active subunit of the caspase-3 protease. Only 1/11 cases of NLPHD demonstrated caspase-3 immunopositivity in lymphocytic/histiocytic cells. Caspase-3 expression was also evaluated in three CHD cell lines, HS445, L428, and KMH2. Whereas caspase-3 expression was detected in HS445 and L428 cell lines, no expression was found in KMH2 cells by immunohistochemical staining. Treatment of HS445 and L428 cell lines for 72 hours with agonistic CD95 monoclonal antibody induced marked apoptosis that was significantly inhibited by pretreatment with the caspase-3 inhibitor, DEVD-FMK, as determined by terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay and flow cytometric analysis of 7-amino-actinomycin D staining. In addition, a significant increase in caspase-3 activity as determined by an enzyme colorimetric assay was detected in HS445 and L428 cells after 48 hours of CD95 stimulation. In marked contrast, treatment of caspase-3-deficient KMH2 cells with anti-CD95 mAb did not demonstrate an increase in caspase-3 activity or induce apoptosis. These data demonstrate caspase-3 is important for CD95-mediated apoptosis in CHD cell lines. In addition, the majority of NLPHD cases examined in this study failed to express detectable levels of caspase-3, suggesting these tumor cells may be resistant to apoptotic stimuli dependent on caspase-3 activity. Furthermore, these data suggest the differential expression of caspase-3 noted between NLPHD and CHD may provide additional evidence that each is a unique disease entity.

Izban, Keith F.; Wrone-Smith, Tamara; Hsi, Eric D.; Schnitzer, Bertram; Quevedo, Maria Eugenia; Alkan, Serhan

1999-01-01

273

Pseudo-Gaucher cells in the bone marrow of a patient with Hodgkin's disease.  

PubMed

The authors studied an 18-year-old woman with stage IIIB nodular sclerosis Hodgkin's disease whose bone marrow contained abnormal storage cells that resembled Gaucher cells by light microscopic examination ("pseudo-Gaucher" cells). Electron microscopic examination revealed that these cells differed from true Gaucher cells and resembled storage cells previously described in chronic myelogenous leukemia. The patient's peripheral blood leukocyte beta-glucosidase and serum acid phosphatase levels were elevated, ruling out the diagnosis of inherited Gaucher's disease. After treatment with six monthly cycles of systemic chemotherapy (nitrogen mustard, vincristine, procarbazine, bleomycin, doxorubicin, and prednisone), all signs of Hodgkin's disease and pseudo-Gaucher cells disappeared. Repeat leukocyte beta-glucosidase and serum acid phosphatase levels were unchanged. The present case is unique with its documentation of classical enzyme patterns for beta-glucosidase and acid phosphatase and electron microscopic features. The authors postulate that pseudo-Gaucher cells result from excessive cell breakdown with an overload of available beta-glucosidase. PMID:3103422

Zidar, B L; Hartsock, R J; Lee, R E; Glew, R H; LaMarco, K L; Pugh, R P; Raju, R N; Shackney, S E

1987-04-01

274

Where does brentuximab vedotin fit into the management of patients with Hodgkin lymphoma?  

PubMed

Brentuximab vedotin is an antibody-drug conjugate that targets CD30 and links monomethyl auristatin E, a microtubule disrupting agent, to an anti-CD30 monoclonal antibody. A phase II study of brentuximab vedotin in relapsed/refractory classical Hodgkin lymphoma (cHL) showed an impressive overall response rate of 75 % with 34 % complete responses, and median remission duration of 20 months in complete responders. In addition, brentuximab vedotin has very modest toxicity in heavily pretreated patients, with reversible peripheral neuropathy being the most common side effect. Brentuximab vedotin received accelerated FDA approval in August 2011 for use as a salvage therapy in cHL following failure of at least two prior therapies. Brentuximab vedotin is the treatment of choice for patients relapsing after stem cell transplant and for patients refractory to standard salvage regimens pre-transplant. Because of high single-agent activity and limited side effects, brentuximab vedotin has emerged as an ideal drug to test in combination therapy for cHL. Current trials are examining the use of brentuximab vedotin in frontline combination regimens, as salvage therapy prior to stem cell transplant, and as adjuvant treatment post-transplant. Such studies will help clarify the optimal use of brentuximab vedotin in the treatment paradigm for Hodgkin lymphoma. PMID:22669711

Goyal, Sagun D; Bartlett, Nancy L

2012-09-01

275

Phosphorylated STAT5 represents a new possible prognostic marker in Hodgkin lymphoma.  

PubMed

An important pathogenetic mechanism in Hodgkin lymphoma (HL) is the interaction between the neoplastic and reactive cells mediated by a complex network of cytokines with activation of cytokine signal transduction (STAT) pathways. We studied the prognostic impact of the phosphorylation status of STAT5 in HL. By using immunohistochemical analysis, we found phosphorylated STAT5 (pSTAT5) in 35 (38%) of 93 lymph node biopsy specimens of patients with HL. The detection of pSTAT5 in Hodgkin and Reed-Sternberg (HRS) cells in classical HL (cHL) was not associated with any clinical and biologic features evaluated, including Epstein-Barr virus status. The primary end point for analysis of clinical outcome was freedom from treatment failure (FFTF). At a median follow-up of 5 years, pSTAT5+ patients with cHL had a better FFTF than pSTAT5-patients (77% vs 56%; P = .03), which translated into a reduced risk for failure for pSTAT5+ patients with a hazard ratio of 0.2 (95% confidence interval, 0.06-0.73; P = .015). Our data suggest that the phosphorylation status of STAT5 of HRS cells in cHL could be a prognostic marker in HL. PMID:18285272

Martini, Maurizio; Hohaus, Stefan; Petrucci, Giovanna; Cenci, Tonia; Pierconti, Francesco; Massini, Giuseppina; Teofili, Luciana; Leone, Giuseppe; Larocca, Luigi M

2008-03-01

276

Hodgkin's lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments  

PubMed Central

Background Hodgkin's lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4+ T?cells. Aims To analyse the expression of the key regulatory T?cell transcription factors (TFs) in the T?cells of HL involved tissues in order to assess the nature of the TH immune response in HL. Methods and results By immunohistochemistry, GATA3 was strongly and T?bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance of T?bet+ T?cells and lesser amounts of GATA3+ and c?Maf+ T?cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c?Maf was observed mostly in T?lymphocytes within the germinal centres (GCs). Nodular lymphocyte predominance type of Hodgkin's lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c?Maf+ T?cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c?Maf+/CD57+ T?cell rosettes around the neoplastic cells; these rosettes were absent in “paragranuloma?type” T?cell/histiocyte rich B?cell lymphoma. Conclusions T?cell TF expression profiles of the reactive T?cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments.

Atayar, Cigdem; van den Berg, Anke; Blokzijl, Tjasso; Boot, Marcel; Gascoyne, Randy D; Visser, Lydia; Poppema, Sibrand

2007-01-01

277

Morphologic changes in the thyroid after irradiation for Hodgkin's and non-Hodgkin's lymphoma  

SciTech Connect

Four cases of thyroidectomy for suspected thyroid carcinoma after previous irradiation for Hodgkin's or non-Hodgkin's lymphoma are reviewed. The patients ranged in age from 18 to 33 years at the time of thyroid surgery with an average latency period of 12 years (range, 8-20 years) from radiation therapy to thyroidectomy. All patients had a clinically palpable thyroid nodule, and pathologically showed a pattern of multiple adenomatous nodules with cytologic atypia. The microscopic changes were sufficiently striking to cause the primary pathologist to request consultation to rule out thyroid carcinoma in each case. Fine-needle aspiration was performed in one case and suggested a thyroid neoplasm. The pathologic findings are reviewed and distinction of this lesion from thyroid carcinoma is discussed.

Carr, R.F.; LiVolsi, V.A.

1989-08-15

278

Connective tissue growth factor is expressed in malignant cells of Hodgkin lymphoma but not in other mature B-cell lymphomas.  

PubMed

Connective tissue growth factor (CTGF) has a major role in development of fibrosis and in the wound-healing process. Microarray analysis of 44 classical Hodgkin lymphoma (cHL) samples showed higher CTGF messenger RNA expression in the nodular sclerosis (NS) than in the mixed cellularity (MC) subtype. When analyzed by immunohistochemical analysis, Hodgkin-Reed-Sternberg (H-RS) cells and macrophages in 23 cHLs and "popcorn" cells in 2 nodular lymphocyte predominant Hodgkin lymphomas showed expression of CTGF protein correlating with the extent of fibrosis. In NS, CTGF was also expressed in fibroblasts and occasional lymphocytes. Malignant cells in 32 samples of various non-Hodgkin lymphomas were negative for CTGF. A staining pattern of stromal cells similar to that of NS cHL was seen in anaplastic large cell lymphoma. Macrophages stained positively in Burkitt lymphomas and in some mantle cell lymphomas. The high occurrence of fibrosis in cHL may be related to CTGF expression by malignant H-RS cells. PMID:20093237

Birgersdotter, Anna; Baumforth, Karl R N; Wei, Wenbin; Murray, Paul G; Sjöberg, Jan; Björkholm, Magnus; Porwit, Anna; Ernberg, Ingemar

2010-02-01

279

Mutations in the genes coding for the NF-?B regulating factors I?B? and A20 are uncommon in nodular lymphocyte-predominant Hodgkin's lymphoma  

PubMed Central

Nodular lymphocyte-predominant Hodgkin’s lymphoma (NLPHL) shows constitutive NF-?B activity in the malignant lymphocyte-predominant (LP) cells. Constitutive NF-?B activity also plays a central pathogenetic role in classical Hodgkin’s lymphoma (cHL), where inactivating mutations in the NFKBIA and TNFAIP3 genes, coding for the negative NF-?B regulators I?B? and A20, respectively, contribute to NF-?B activation. To determine whether mutations in NFKBIA and TNFAIP3 are also involved in the pathogenesis of NLPHL these genes were sequenced from microdissected LP cells of 10 primary NLPHL. We also studied DEV, the only cell line proposedly derived from LP cells, after we had confirmed its derivation from NLPHL by gene expression analysis. A heterozygous somatic missense mutation in the NFKBIA gene was found in one NLPHL, and a heterozygous, possibly subclonal, two base pair insertion in TNFAIP3 in another case. The low mutation frequency and the absence of biallelic destructive mutations propose a minor contribution of NFKBIA and TNFAIP3 mutations to the NF-?B activity of NLPHL, suggesting different mechanisms of NF-?B activation in NLPHL and cHL.

Schumacher, Martin A.; Schmitz, Roland; Brune, Verena; Tiacci, Enrico; Doring, Claudia; Hansmann, Martin-Leo; Siebert, Reiner; Kuppers, Ralf

2010-01-01

280

Hodgkin disease and non-Hodgkin lymphomas in children: utilization of radiological modalities  

SciTech Connect

If costs of medical care are to be reduced, the choice of which imaging modality to use must be made as carefully as possible. This study was done to show how radiological modalities were used to evaluate patients with Hodgkin disease and non-Hodgkin lymphoma. We kept a record of every radiological study performed on 66 children with both diseases seen in the past 6 1/3 years. The results of these studies were analyzed to see which areas of the body were studied, which imaging modality was used, how frequently the studies were repeated, and how frequently the studies gave abnormal results. Our findings disclosed that radiological studies have been appropriately performed in anatomic regions of the body in which disease is present. New imaging modalities have been introduced, and the use of some of the older modalities has been decreased. With some modalities, such as skeletal survey, liver/spleen scan, whole-lung tomography, contrast studies of the bowel, and excretory urography, utilization is higher than it ought to be in view of the fact that the yield of positive results is low and the information is obtainable in many cases from other more sensitive procedures. These studies should not be performed as a routine on initial evaluation or follow-up of all patients with Hodgkin or non-Hodgkin lymphomas. On initial presentation all patients should undergo chest radiography and CT scanning of both chest and abdomen. A problem area is that the timing of follow-up studies has been somewhat erratic, with some inappropriate studies particularly 3 or 4 years after diagnosis. Too many imaging procedures have probably been done in follow-up of our patients.

Cohen, M.D.; Siddiqui, A.; Weetman, R.; Provisor, A.; Coates, T.

1986-02-01

281

Combination chemotherapy of childhood non-Hodgkin's lymphomas  

SciTech Connect

The rationale for the treatment of the non-Hodgkin's lymphomas in childhood is discussed. Results from recent trials of combination chemotherapy are given, and the treatment strategy of the United Kingdom Children's Cancer Study Group is described.

Mott, M.G.

1981-01-01

282

Diagnosis and Treatment of Non-Hodgkin's Lymphomas.  

National Technical Information Service (NTIS)

The Cancergram focuses on a group of lymphomas which includes adenolymphoma, Burkitt's lymphoma, lymphosarcoma, lymphoblastoma, lymphocytoma, reticulum cell sarcoma, mycosis fungoides, and any not otherwise specified lymphoma with the exception of Hodgkin...

1977-01-01

283

The Hodgkin-Huxley heritage: from channels to circuits.  

PubMed

The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin's and Huxley's ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost. PMID:23055474

Catterall, William A; Raman, Indira M; Robinson, Hugh P C; Sejnowski, Terrence J; Paulsen, Ole

2012-10-10

284

How Is Non-Hodgkin Lymphoma Diagnosed in Children?  

MedlinePLUS

... Hodgkin lymphoma Imaging tests use x-rays, sound waves, magnetic fields, or radioactive substances to create pictures ... under a microscope. Ultrasound (sonogram) Ultrasound uses sound waves and their echoes to produce a picture of ...

285

[The treatment of patients with refractory forms of Hodgkin's lymphomas].  

PubMed

The treatment of patients with refractory forms of Hodgkin's lymphomas in combination with chemo-radiotherapy is priority. Nevertheless, chemotherapy has to include multicomponent schemes and radiation therapy should be an addition and consolidative method to chemotherapy. PMID:20608037

Hubareva, H O; Kriachok, I A; Tytorenko, I B; Aleksyk, O M; Novosad, O I; Kadnikova, T V; Martynchyk, A V; Pastushenko, Ia V; Filonenko, K S; Kushchevy?, Ie V

286

The classic project  

SciTech Connect

Exchange of data and algorithms among accelerator physics programs is difficult because of unnecessary differences in input formats and internal data structures. To alleviate these problems a C++ class library called CLASSIC (Class Library for Accelerator System Simulation and Control) is being developed with the goal to provide standard building blocks for computer programs used in accelerator design. It includes modules for building accelerator lattice structures in computer memory using a standard input language, a graphical user interface, or a programmed algorithm. It also provides simulation algorithms. These can easily be replaced by modules which communicate with the control system of the accelerator. Exchange of both data and algorithm between different programs using the CLASSIC library should present no difficulty. {copyright} {ital 1997 American Institute of Physics.}

Iselin, F.C. [CERN, SL Div., AP Group, CH-1211 Geneva 23 (Switzerland)

1997-02-01

287

The classic project  

SciTech Connect

Exchange of data and algorithms among accelerator physics programs is difficult because of unnecessary differences in input formats and internal data structures. To alleviate these problems a C++ class library called CLASSIC (Class Library for Accelerator System Simulation and Control) is being developed with the goal to provide standard building blocks for computer programs used in accelerator design. It includes modules for building accelerator lattice structures in computer memory using a standard input language, a graphical user interface, or a programmed algorithm. It also provides simulation algorithms. These can easily be replaced by modules which communicate with the control system of the accelerator. Exchange of both data and algorithm between different programs using the CLASSIC library should present no difficulty.

Iselin, F. Christoph [CERN, SL Div., AP Group, CH-1211 Geneva 23 (Switzerland)

1997-02-01

288

Classical Live Viral Vaccines  

Microsoft Academic Search

\\u000a Classical, live viral vaccines have been developed by adapting viruses by serial passages in animals, tissue or cell cultures\\u000a during which multiple mutations in the viral genome have accumulated. The majority of vaccines in use today were developed\\u000a in this way and a number of similar investigational vaccines are currently in development. The principal advantage of live\\u000a vaccines is that

Thomas P. Monath

289

Revisiting a Classic  

ERIC Educational Resources Information Center

|As a 26-year-old English teacher in 1958, Chinua Achebe had no idea that the book he was writing would become a literary classic, not only in Africa but also throughout the world. He could only try to articulate the feelings he had for his countrymen and women. Achebe had a burning desire to tell the true story of Africa and African humanity. The…

Rogers, Ibram

2008-01-01

290

Classical Helium Program  

NSDL National Science Digital Library

The classical-physics model of helium is a simple example of a three body problem and is similar to gravitational problem of a heavy sun and two light planets. It consists of two electrons moving in a 2/r potential well and interacting through a 1/r potential. Initial conditions can be set to show phenomena such as autoionization or braided orbits. These conditions are stored in an xml document.

Christian, Wolfgang; Gould, Harvey; Tobochnik, Jan

2008-05-21

291

Classical probability waves  

Microsoft Academic Search

Probability waves in the configuration space are associated with coherent solutions of the classical Liouville or Fokker–Planck equations. Distributions localized in the momentum space provide action waves, described by the probability density and the generating function of the Hamilton–Jacobi theory. It is shown that by introducing a minimum distance in the coordinate space, the action distributions aquire the phase–space dispersion

Marius Grigorescu

2008-01-01

292

Entanglement with classical fields  

SciTech Connect

We experimentally demonstrate a simple classical-field optical heterodyne method which employs postselection to reproduce the polarization correlations of a four-particle entangled state. We give a heuristic argument relating this method to the measurement of multiple quantum fields by correlated homodyne detection. We suggest that using multiple classical fields and postselection, one can reproduce the polarization correlations obtained in quantum experiments which employ multiple single-photon sources and linear optics to prepare multiparticle entangled states. Our experimental scheme produces four spatially separated beams which are separately detected by mixing with four independent optical local oscillators (LO) of variable polarization. Analog multiplication of the four beat signals enables projection onto a four-particle polarization-state basis. Appropriate band pass filtering is used to produce a signal proportional to the projections of the maximally entangled four-field polarization state, H{sub 1})H{sub 2})H{sub 3})H{sub 4})+V{sub 1})V{sub 2})V{sub 3})V{sub 4}), onto the product of the four LO polarizations. Since the data from multiple observers is combined prior to postselection, this method does not constitute a test of nonlocality. However, we reproduce the polarization correlations of the 32 elements in the truth table from the quantum mechanical Greenberger-Horne-Zeilinger experiments on the violation of local realism. We also demonstrate a form of classical entanglement swapping in a four-particle basis.

Lee, K.F.; Thomas, J.E. [Physics Department, Duke University, Durham, North Carolina 27708-0305 (United States)

2004-05-01

293

Pancoast syndrome: A rare presentation of non-Hodgkin's lymphoma  

PubMed Central

Pancoast syndrome is a common presentation of bronchogenic carcinoma, but other malignancies are rarely cited as its cause. Pancoast syndrome due to non-Hodgkin's lymphoma is rarely described in the literature. Here, we report a case of Pancoast syndrome due to non-Hodgkin's lymphoma to increase the awareness of the clinicians regarding essentiality of tissue diagnosis of Pancoast tumor before starting the treatment.

Sarkar, Anirban; Das, Anirban; Basuthakur, Sumitra; Pandit, Sudipta; Das, Sibes K.; Choudhury, Sabyasachi

2013-01-01

294

Plasma Biomarkers for Detecting Hodgkin's Lymphoma in HIV Patients  

Microsoft Academic Search

The lifespan of people with human immunodeficiency virus (HIV) infection has increased as a result of effective antiretroviral therapy, and the incidences of the AIDS-defining cancers, non-Hodgkin's lymphoma and Kaposi sarcoma, have declined. Even so, HIV-infected individuals are now at greater risk of other cancers, including Hodgkin's lymphoma (HL). To identify candidate biomarkers for the early detection of HL, we

Susan M. Varnum; Bobbie-Jo M. Webb-Robertson; Nancy A. Hessol; Richard D. Smith; Richard C. Zangar

2011-01-01

295

Ultraviolet Radiation Exposure and Risk of Non-Hodgkin's Lymphoma  

Microsoft Academic Search

Sun exposure has been suggested to increase the risk of non-Hodgkin's lymphoma. The authors analyzed data from a population-based, case-control study of Connecticut women between 1996 and 2000 to study the hypoth- esis. Women who reported having had a suntan experienced an increased risk of non-Hodgkin's lymphoma with increasing duration (ptrend ¼ 0.0062) compared with women who reported never having

Yawei Zhang; Theodore R. Holford; Brian Leaderer; Peter Boyle; Yong Zhu; Rong Wang; Kaiyong Zou; Bing Zhang; John Pierce Wise; Qin Qin; Briseis Kilfoy; Jiali Han; Tongzhang Zheng

296

CT demonstration of peripelvic and periureteral non-Hodgkin lymphoma  

SciTech Connect

Abdominal CT is often performed for the staging of lymphoma. Retroperitoneal lymphadenopathy is the most common abnormality identified, but various extranodal sites of lymphomatous involvement have been reported, especially in non-Hodgkin lymphoma. Renal involvement is not rare, but peripelvic or periureteral involvement in the absence of renal parenchymal involvement or contiguous abdominal adenopathy is extremely unusual. Two recent patients with non-Hodgkin lymphoma who did show these findings are presented.

McMillin, K.I.; Gross, B.H.

1985-05-01

297

Economic Burden of Follicular Non-Hodgkin's Lymphoma  

Microsoft Academic Search

Follicular non-Hodgkin's lymphoma (FNHL), a slow-growing cancer of the immune system, constitutes about 15-30% of all incident non-Hodgkin's lymphoma in developed countries. Its incidence is rising worldwide. Patients can live many years, but FNHL is considered incurable. We systematically reviewed the English-language MEDLINE-indexed and non-indexed economic literature published in the past 10 years on FNHL, identifying 23 primary economic studies.

Talia Foster; Jeffrey D. Miller; Mark E. Boye; Mason W. Russell

2009-01-01

298

Hodgkin-Huxley type electronic modelling of gastrointestinal electrical activity  

Microsoft Academic Search

An electronic model comprising a number of coupled Hodgkin-Huxley type nonlinear oscillators is described. The individual\\u000a oscillator units are based on a simplified version of an analogue of the Hodgkin-Huxley squid axon membrane due to Roy (1972).\\u000a The electronic model is capable of reproducing physiological phenomena such as ‘waxing and waning’ and frequency entrainment\\u000a which have been observed in electrical

R. J. Patton; D. A. Linkens

1978-01-01

299

Lung Cancer Following Chemotherapy and Radiotherapy for Hodgkin's Disease  

Microsoft Academic Search

Background: Lung cancer is a frequent cause of death in patients cured of Hodgkin's disease, but the contributions of chemotherapy, radiotherapy, and smoking are not well de- scribed.We quantified the risk of treatment-associated lung cancer, taking into account tobacco use. Methods: Within a population-based cohort of 19 046 Hodgkin's disease patients (diagnosed from 1965 through 1994), a case-control study of

Lois B. Travis; Mary Gospodarowicz; Rochelle E. Curtis; E. Aileen Clarke; Michael Andersson; Bengt Glimelius; Timo Joensuu; Charles F. Lynch; Eric Holowaty; Hans Storm; Ingrid Glimelius; Eero Pukkala; Marilyn Stovall; Joseph F. Fraumeni; John D. Boice; Ethel Gilbert

2002-01-01

300

Extended-Field Isocentric Irradiation for Hodgkin's Disease  

PubMed Central

Extended-field therapeutic irradiation is the treatment of choice for the majority of patients diagnosed with pathologic stages I and II Hodgkin's disease, and total nodal irradiation can be effectively used to treat selected stage III Hodgkin's patients. Standard 100-cm source-to-axis distance extended-field isocentric technique and results are presented. ImagesFigure 1Figure 2Figure 3Figure 4Figure 5Figure 6Figure 7

Kumar, P. Pradeep; Good, Roger R.; Jones, Ernest O.; Somers, James E.; McAnulty, Bruce E.; McCaul, Gayle F.; Rogers, Sally S.; Reeves, Michael A.; Sanders, Cheryl K.

1987-01-01

301

Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features  

PubMed Central

Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper.

Bertucci, Francois; Chetaille, Bruno; Xerri, Luc

2011-01-01

302

Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features.  

PubMed

Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper. PMID:21197104

Bertucci, François; Chetaille, Bruno; Xerri, Luc

2010-12-13

303

Hodgkin lymphoma, version 2.2012 featured updates to the NCCN guidelines.  

PubMed

The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Hodgkin Lymphoma (HL) include the clinical management of classical HL and lymphocyte-predominant HL (LPHL). Major changes have been incorporated into these guidelines since their inception. In the 2012 NCCN Guidelines for HL, PET scans are not recommended for interim restaging of patients with stage I to II favorable disease. After reevaluating the available evidence on the use of interim PET imaging, the panel recommends the use of diagnostic CT scan of involved sites for interim restaging after completion of chemotherapy for this group of patients. Maintenance rituximab for 2 years is included as an option for patients with stage IB to IIB or stage III to IV LPHL treated with rituximab alone in the first-line setting. Brentuximab vedotin is included as an option for patients with progressive disease or relapsed disease after second-line chemotherapy or high-dose therapy with autologous stem cell rescue. PMID:22570290

Hoppe, Richard T; Advani, Ranjana H; Ai, Weiyun Z; Ambinder, Richard F; Aoun, Patricia; Bello, Celeste M; Bierman, Philip J; Blum, Kristie A; Chen, Robert; Dabaja, Bouthaina; Duron, Ysabel; Forero, Andres; Gordon, Leo I; Hernandez-Ilizaliturri, Francisco J; Hochberg, Ephraim P; Maloney, David G; Mansur, David; Mauch, Peter M; Metzger, Monika; Moore, Joseph O; Morgan, David; Moskowitz, Craig H; Poppe, Matthew; Pro, Barbara; Winter, Jane N; Yahalom, Joachim; Sundar, Hema

2012-05-01

304

Pediatric Hodgkin's lymphoma: changing concepts and moving points in radiation therapy.  

PubMed

The classic treatment of Hodgkin's lymphoma (HL) in children resulted in significant late toxicity in long-term survivors. Late treatment effects included skeletal, cardio- pulmonary, gonadal toxicities, and second malignant tumor (SMN). This has driven pediatric HL groups to adopt treatment strategies using less intense chemotherapy, less alkylating agents, reduced radiation dose and volume, and omission of radiation therapy in selected group of patients. In limited disease, the aim is to maintain a high cure rate with minimal side effects. Patients with advanced-stage HL have a lower outcome, and need treatment intensification. Dose-dense, risk and response-adapted treatment strategies are evolving aiming at improving outcome and reducing toxicity. PMID:23769169

Khafaga, Yasser M; Belgaumi, Asim F

2013-06-12

305

Acoustics of Chinese traditional theatres  

Microsoft Academic Search

Chinese traditional theatre is unique in the world as an architectural form. The Chinese opera evolved into maturity as early as the Song and Yuan Dynasties, 11th-14th centuries, and Chinese theatrical buildings developed accordingly. As the Chinese opera plays on the principle of imaginary actions, no realistic stage settings are required. But Chinese audiences have placed great demands on vocal

J. Q. Wang

2002-01-01

306

Primary extranodal non-Hodgkin's lymphoma.  

PubMed

A total of 52 of 238 patients (22%) with non-Hodgkin's lymphoma presented with disease in a primary extranodal site. The gastrointestinal tract was the commonest site involved (50%) and diffuse large cell was the commonest histological sub-type of the lymphoma (64%). Survivorship analysis of these patients, treated predominantly with chemotherapy, suggests that long-term survival is associated with: low-grade malignancy--median survival greater than 120 months; localized disease or spread of disease confined to the regional lymph nodes--median survival 65.5 months; and the use of aggressive combination chemotherapy for intermediate grade malignancy when the disease is localized or spread is confined to the regional lymph nodes--median survival greater than 110 months. PMID:3822520

Manoharan, A; Smart, R C; Pitney, W R

1986-10-01

307

Collagenofibrotic glomerulopathy in association with Hodgkin's lymphoma.  

PubMed

Deposit glomerulopathies are characterized by fibrillary deposits of various sizes, mainly in the mesangial area. Collagenofibrotic glomerulopathy is a rare type of such fibrillary glomerulopathies characterized by deposits of 60-80 nm fibrils in the sub-endothelial and mesangial areas. It is also associated with increased levels of serum pro-collagen type III peptide (PIIINP). Although most of the initial reports have emanated from Japan, many other scientists around the globe have later reported this disease. Possibility of systemic disease affecting metabolism of type III collagen is postulated but so far no such association has been identified. We report a 26-year-old male patient who presented with insidious onset of febrile illness associated with lymphadenopathy and proteinuria. Lymph node biopsy revealed features of Hodgkin's lymphoma while percutaneous renal biopsy showed features of collagenofibrotic glomerulopathy. PMID:21196628

Soni, Sachin S; Gowrishankar, Swarnalata; Nagarik, Amit P; Barnela, Sriganesh R; De Padua, Michelle; Adikey, Gopal Kishan; Raman, Anuradha

2011-01-01

308

Biomarkers in childhood non-Hodgkin's lymphomas.  

PubMed

Pediatric non-Hodgkin's lymphomas (NHLs) are a heterogeneous group of malignancies with distinct clinical, pathological, immunological and genetic characteristics. More than 90% of pediatric NHLs belong to one of three major histological subtypes: mature B-cell neoplasms, lymphoblastic lymphomas and anaplastic large-cell lymphomas. The recognition that different subtypes require different treatment regimens resulted in therapeutic strategies leading to over 80% of patients being cured. On the other hand, patients with resistant or relapsed disease have a poor prognosis. Prognostic biomarkers have not yet been identified for all pediatric NHLs and, although some are very important for diagnosis and prognosis, others may be of questionable value. Discovery of new biomarkers suitable for clinical application may aid the diagnosis and classification of lymphomas, which should, in turn, lead to better patient stratification. Consequent development of new treatment and follow-up approaches should lead to more efficient and less toxic treatment in children with NHL. PMID:24044571

Dokmanovic, Lidija

2013-10-01

309

The Rationale behind a Reticular Meridain Model for Chinese Acupuncture  

Microsoft Academic Search

Recently, a reticular model based on classical Chinese meridian systems was proposed to explain the mechanism of acupuncture. In this paper, the rationale behind this model is thoroughly discussed. Basically, it is based on the theory of embryogenesis, physiological experiments, and effects of acupuncture. It is believed that the cable theory of reticular meridian networks, not the neuron doctrine, can

Shyang Chang

2010-01-01

310

Clinical features and outcomes of Hodgkin’s lymphoma in Korea: Consortium for Improving Survival of Lymphoma (CISL)  

Microsoft Academic Search

Ethnic and regional differences in the epidemiology and pathological aspects of Hodgkin’s lymphoma (HL) between Western and\\u000a Asian patients may be associated with differences in clinical features and prognosis. We retrospectively analyzed the clinical\\u000a and histopathological characteristics, therapeutic outcomes, and prognostic factors of 539 HL patients treated at 16 centers\\u000a in Korea. We found that the incidence of histological subtypes

Young-Woong Won; Jung Hye Kwon; Soon Il Lee; Sung Yong Oh; Won Seog Kim; Seok Jin Kim; Jong-Ho Won; Kyoung Ha Kim; Seong Kyu Park; Jin Seok Kim; Cheolwon Suh; Dok Hyun Yoon; Joon Seong Park; Min Kyoung Kim; Hawk Kim; Hye Jin Kang; Yeung-Chul Mun; Jae-Yong Kwak; Hyo Jung Kim; Hyeon-Seok Eom

311

GLUT1 expression patterns in different Hodgkin lymphoma subtypes and progressively transformed germinal centers  

PubMed Central

Background Increased glycolytic activity is a hallmark of cancer, allowing staging and restaging with 18F-fluorodeoxyglucose-positron-emission-tomography (PET). Since interim-PET is an important prognostic tool in Hodgkin lymphoma (HL), the aim of this study was to investigate the expression of proteins involved in the regulation of glucose metabolism in the different HL subtypes and their impact on clinical outcome. Methods Lymph node biopsies from 54 HL cases and reactive lymphoid tissue were stained for glucose transporter 1 (GLUT1), lactate dehydrogenase A (LDHA) and lactate exporter proteins MCT1 and MCT4. In a second series, samples from additional 153 HL cases with available clinical data were stained for GLUT1 and LDHA. Results Membrane bound GLUT1 expression was frequently observed in the tumor cells of HL (49% of all cases) but showed a broad variety between the different Hodgkin lymphoma subtypes: Nodular sclerosing HL subtype displayed a membrane bound GLUT1 expression in the Hodgkin-and Reed-Sternberg cells in 56% of the cases. However, membrane bound GLUT1 expression was more rarely observed in tumor cells of lymphocyte rich classical HL subtype (30%) or nodular lymphocyte predominant HL subtype (15%). Interestingly, in both of these lymphocyte rich HL subtypes as well as in progressively transformed germinal centers, reactive B cells displayed strong expression of GLUT1. LDHA, acting downstream of glycolysis, was also expressed in 44% of all cases. We evaluated the prognostic value of different GLUT1 and LDHA expression patterns; however, no significant differences in progression free or overall survival were found between patients exhibiting different GLUT1 or LDHA expression patterns. There was no correlation between GLUT1 expression in HRS cells and PET standard uptake values. Conclusions In a large number of cases, HRS cells in classical HL express high levels of GLUT1 and LDHA indicating glycolytic activity in the tumor cells. Although interim-PET is an important prognostic tool, a predictive value of GLUT1 or LDHA staining of the primary diagnostic biopsy could not be demonstrated. However, we observed GLUT1 expression in progressively transformed germinal centers and hyperplastic follicles, explaining false positive results in PET. Therefore, PET findings suggestive of HL relapse should always be confirmed by histology.

2012-01-01

312

The roots of Chinese philosophy and culture — An introduction to “ xiang ” and “ xiang thinking”  

Microsoft Academic Search

To grasp the truth in traditional Chinese classics, we need to uncover the long obscured “xiang” ? (image) thinking, which has long been overshadowed by Occidentalism. “xiang thinking” is the most fundamental thought of human beings. The logic of linguistics all comes from “xiang thinking”. Through conceptual thinking, people can understand Western classics on metaphysics, yet they may not completely

Shuren Wang

2009-01-01

313

[The establishment, contributions, and final results of classical medical theories].  

PubMed

In countries with ancient civilization of both Eastern world and Western world, after the accumulation of clinical experiences of "empirical medicine" to a sufficient amount; in accordance of their primitive philosophical thoughts, classical medical theories were established to play an important role in guiding the clinical practice of "empirical medicine". Because of the similarity of philosophical thoughts all over the ancient world, their medical theories were also very similar to each other. After the scientific evaluation and improvement, Greek classical medical theories were inherited, refined or abandoned, and then eventually finished their historical mission. Chinese classical medical theories also need the similar scientific identification and improvement for flowing into the authorized main stream of modern medical theory systems to continuously apply their guiding roles in clinical practice. Scholars would better consider the developmental principles of cultures and sciences with a historical viewpoint and an open mind to avoid making mistakes from haughty and prejudice. PMID:23596779

Wang, Tai

2013-01-01

314

Teaching and Demonstrating Classical Conditioning.  

ERIC Educational Resources Information Center

|Discusses classroom demonstrations of classical conditioning and notes tendencies to misrepresent Pavlov's procedures. Describes the design and construction of the conditioner that is used for demonstrating classical conditioning. Relates how students experience conditioning, generalization, extinction, discrimination, and spontaneous recovery.…

Sparrow, John; Fernald, Peter

1989-01-01

315

Zhou Enlai and Chinese Grand Strategy.  

National Technical Information Service (NTIS)

0000e are comparatively few books about Chinese foreign policy in Chinese or English. Aside from the writings of Mao Zedong, there are virtually no specific books in Chinese about Chinese 'grand strategy.' Contemporary Chinese writers actually write very ...

R. J. Latham

1990-01-01

316

Automated parameter estimation of the Hodgkin-Huxley model using the differential evolution algorithm: application to neuromimetic analog integrated circuits.  

PubMed

We propose a new estimation method for the characterization of the Hodgkin-Huxley formalism. This method is an alternative technique to the classical estimation methods associated with voltage clamp measurements. It uses voltage clamp type recordings, but is based on the differential evolution algorithm. The parameters of an ionic channel are estimated simultaneously, such that the usual approximations of classical methods are avoided and all the parameters of the model, including the time constant, can be correctly optimized. In a second step, this new estimation technique is applied to the automated tuning of neuromimetic analog integrated circuits designed by our research group. We present a tuning example of a fast spiking neuron, which reproduces the frequency-current characteristics of the reference data, as well as the membrane voltage behavior. The final goal of this tuning is to interconnect neuromimetic chips as neural networks, with specific cellular properties, for future theoretical studies in neuroscience. PMID:21671785

Buhry, Laure; Grassia, Filippo; Giremus, Audrey; Grivel, Eric; Renaud, Sylvie; Saïghi, Sylvain

2011-06-14

317

Hodgkin Lymphoma Treatment Tied to Higher Risk of Stomach Cancer in Study  

MedlinePLUS

... Hodgkin Lymphoma Treatment Tied to Higher Risk of Stomach Cancer in Study Chemo, radiation doses to the stomach ... 2013 Related MedlinePlus Pages Cancer Chemotherapy Hodgkin Disease Stomach Cancer WEDNESDAY, Aug. 28 (HealthDay News) -- Certain radiation and ...

318

Fano Interference in Classical Oscillators  

ERIC Educational Resources Information Center

|We seek to illustrate Fano interference in a classical coupled oscillator by using classical analogues of the atom-laser interaction. We present an analogy between the dressed state picture of coherent atom-laser interaction and a classical coupled oscillator. The Autler-Townes splitting due to the atom-laser interaction is analogous to the…

Satpathy, S.; Roy, A.; Mohapatra, A.

2012-01-01

319

IMP3 as a supplemental diagnostic marker for Hodgkin lymphoma.  

PubMed

Insulin-like growth factor II mRNA-binding protein 3 (IMP3) is ubiquitously expressed in embryos, mediating organogenesis, RNA trafficking, and cell growth, and is generally down-regulated in adult tissue. However, IMP3 has recently been shown to be overexpressed in some malignant epithelial neoplasms and to be a useful diagnostic and/or prognostic biomarker for several carcinomas. To determine whether IMP3 might also be an accurate biomarker of Hodgkin lymphoma, we examined 81 Hodgkin lymphomas for immunoreactivity to IMP3 as compared to commonly used markers such as CD30, CD15, PAX5, and MUM1. Consequently, in 98.8% (80/81) of Hodgkin lymphomas, the malignant Hodgkin and Reed-Sternberg cells were selectively reactive for IMP3, with 72.8% (59/81) of the tumors showing strong, diffuse cytoplasmic staining. Positive staining of the Hodgkin lymphomas was also seen for CD30 (82.7%, 67/81), CD15 (65.4%, 53/81), PAX5 (84.0%, 68/81), and MUM1 85.2% (69/81), but significantly fewer cells showed strong staining intensity for CD30 (32.1%, 26/81), CD15 (17.3%, 14/81), PAX5 (12.3%, 10/81), and MUM1 (29.6%, 24/81). Furthermore, the IMP3 staining was selectively restricted to Hodgkin and Reed-Sternberg cells, with a clearly negative background, and complementary to CD30 staining. Our findings show that IMP3 may be a useful diagnostic marker of Hodgkin lymphoma, helping to improve diagnostic accuracy for this malignancy. PMID:23845468

Tang, Hongping; Wei, Qingzhu; Ge, Juan; Jian, Wenjing; Liu, Jiangchuan; Zhong, Lin; Fu, Bo; Zhao, Tong

2013-07-08

320

Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

2013-07-26

321

A Killer of a Classic  

NSDL National Science Digital Library

Now that you've read To Kill a Mockingbird, by Harper Lee, you might have a basis to look at it crically! It is considered a great classic in literary circles. What do you think? What is a classic? Would you call this book a classic? Why or why not? Current Knowledge As a group, create a paper. On the top of the paper, write a definition of a classic, in the literary sense. What makes a book a "classic?" Then, together, compose two lists. One list should be reasons why the book, ...

Griffiths, Mrs.

2009-04-22

322

Immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients, Kampala, Uganda  

Microsoft Academic Search

BACKGROUND: Non Hodgkin lymphomas are the most common lymphomas in Uganda. Recent studies from developed countries have shown differences in survival for the different immunophenotypes. Such studies are lacking in Africa where diagnosis is largely dependent on morphology alone. We report immunohistochemical and other prognostic factors in B cell non Hodgkin lymphoma patients in Kampala, Uganda. METHODS: Non Hodgkin lymphoma

Lynnette K Tumwine; Claudio Agostinelli; Cristina Campidelli; Emmanuel Othieno; Henry Wabinga; Simona Righi; Brunangelo Falini; Pier Paolo Piccaluga; Wilson Byarugaba; Stefano A Pileri

2009-01-01

323

Access Excellence Classic Collection  

NSDL National Science Digital Library

Another good resource from AccessExcellence.org is the Activities Exchange Classic Collection Web site. The page presents links that focus on a single person or event by putting it into historical context and relating it to current science. Each contains a set of references, classroom activities, graphics, background information, and more. Some of the titles of the activities include The Discovery Of Radioactivity: The Dawn of the Nuclear Age; Radioactivity: Historical Figures; How We See: The First Steps of Human Vision; Discovery, Chance, and the Scientific Method; DNA Structure; and Development of Polio Vaccines. The pages and activities are well designed and offer educators some interesting and unique lessons for their students.

324

On Developing Business Chinese.  

ERIC Educational Resources Information Center

Examines the significance of foreign languages for business, particularly Business Chinese, in the 1990s; its curriculum requirements; and the impact of business languages on international business. The article proposes a developmental plan for Business Chinese at the college level including goals, course materials, learning activities, and…

Hong, Wei

1996-01-01

325

Augmented Reality Chinese Checkers  

Microsoft Academic Search

This paper presents an application, Augmented Reality Chinese Checkers that we created to investigate user interface issues for table top projected augmented reality entertainment applications. A new tangible interaction device, the wireless button enhanced fiducial, is introduced to support selection tasks in mixed reality environments. The Augmented Reality Chinese Checkers game is built on a framework which can be used

Nicholas Cooper; Aaron Keatley; Maria Dahlquist; Simon Mann; Hannah Slay; Joanne Zucco; Ross Smith; Bruce H. Thomas

2004-01-01

326

Chinese Chef Training.  

National Technical Information Service (NTIS)

This study was done to recognize the problem of new Chinese immigrants, and the formation of the group called the Immigrants Development Center of San Francisco, Inc., in order to work toward the alleviation of the unemployment problem of recent Chinese i...

1976-01-01

327

Chinese by Choice  

ERIC Educational Resources Information Center

|A 2004 College Board survey revealed that school districts around America wanted to offer Chinese, but finding qualified teachers was a problem, says Selena Cantor, director of Chinese Language and Culture Initiatives for the College Board. So last year, a new College Board program brought guest teachers from China to school districts in 31…

Beem, Kate

2008-01-01

328

The Chinese Calendars  

NASA Astrophysics Data System (ADS)

In this article we try to answer the question how and why did Chinese ancient astronomy came into being and how did one lonesome and original calendar system on the very end of the world develop. At the beginning, Chinese people distinguished time of the year by the annual cycles of plants and animals, but soon began to determine seasons by observing celestial bodies. Early successful measuring of tropical year and synodic month made possible for Chinese people to issue first calendars very early. Spring and Autumn (Chunqiu) period (770 - 476 BC) brought forward first official calendars. Further improvement of calendars is due to the development of new astronomical instruments. Chinese calendars also originate from the metaphysical concepts of Qi, Yin-Yang and 5 elements. 5 elements were connected with Chinese 5 seasons of the year and this was the first form of solar calendar. Later, it developed into solar calendar with 10 months. In the next phase, Chinese calendar turned into lunisolar calendar which also has its evolution. Chinese people invented Calendar "with division by four" (the name of this calendar). They also added 24 solar terms to make calendar harmonize with natural cycles. Li Chunfeng rearranged intercalations and used month without main solar term and divided months into short and long months. Sexagesimal system of time measuring refers to the system of Chinese 10 Heavenly Stems and 12 Earthly Branches. Its purpose is to measure time and define years, months, days and hours.

Kostic, N.; Segan, S.

2009-09-01

329

The ancient Chinese notes on hydrogeology  

NASA Astrophysics Data System (ADS)

The ancient Chinese notes on hydrogeology are summarized and interpreted, along with records of some related matters, like groundwater exploration and utilization, karst springs, water circulation, water conservation and saline-land transformation, mine drainage, and environmental hydrogeology. The report focuses only on the earliest recorded notes, mostly up until the Han Dynasty (206 BC - AD 25). Besides the references cited, the discussion in this report is based mainly on archaeological material, the preserved written classic literature, and some assumptions and/or conclusions that have been handed down in legends to later ages. Although most material relates to ancient China, the lessons learned may have practical significance worldwide. Compared to other contemporary parts of the world, ancient China, without doubt, took the lead in the field of groundwater hydrology. The great achievements and experience of the Chinese ancestors should provide motivation and inspiration for hydrogeologists to carry out their scientific research and exploration passionately and actively.

Zhou, Yu; Zwahlen, François; Wang, Yanxin

2011-08-01

330

Second malignant lesions after therapy for Hodgkin's disease  

SciTech Connect

Among 169 adult pathologically staged patients with Hodgkin's disease who were treated at the Mayo Clinic between 1974 and 1978, four cases of second malignant lesions were identified. The median duration of follow-up after diagnosis for the entire population was 4.1 years. Of the 169 patients, 73 received irradiation only, 19 received chemotherapy only, and 77 received both chemotherapy and radiation therapy. In all four patients with second malignant lesions, Hodgkin's disease was in apparent remission at the time of diagnosis of the second tumor. These four patients had received either total nodal irradiation or six or more cycles of chemotherapy as initial treatment (and one of them had received both treatment modalities). Thus, intensive therapy might be hypothesized to have played a role in the development of the second malignant tumor. The development of non-Hodgkin's lymphoma within a previously irradiated field after treatment of Hodgkin's disease with radiation therapy only is not know to have been reported previously. Although further studies with longer follow-up should be conducted, this analysis supports a definite risk for development of a second malignant lesion not only after combined-modality treatment or chemotherapy for Hodgkin's disease but also after irradiation only.

Schomberg, P.J.; Evans, R.G.; Banks, P.M.; White, W.L.; O'Connell, M.J.; Earle, J.D.

1984-07-01

331

Growing Up the Chinese Way: Chinese Child and Adolescent Development.  

ERIC Educational Resources Information Center

This volume is a collection of current research by noted scholars on Chinese child development. The volume re-examines long-held beliefs and preconceptions about Chinese culture, draws forth incompatible pictures and contradictory facts about Chinese children, and draws attention to new problems of the modern Chinese family. The chapters of the…

Lau, Sing, Ed.

332

Chinese Health Beliefs of Older Chinese in Canada  

Microsoft Academic Search

Objectives: This study examines the cultural health beliefs held by older Chinese in Canada. Methods: Chinese surnames are randomly selected from the local Chinese telephone directories. Telephone screening is then conducted to identify eligible Chinese people 55 years of age or older to take part in a face-to-face interview to complete a structured survey questionnaire. Results: The results of exploratory

Daniel W. L. Lai; Shireen Surood

2009-01-01

333

Chinese paternalistic leadership and non-Chinese subordinates' psychological health  

Microsoft Academic Search

Past research on Chinese leadership, a style which is different from that practiced in the West, has demonstrated that paternalistic leadership within Chinese society is significantly related to employees' psychological health. This research contributes to the literature by providing results from the interaction between Chinese and non-Chinese society and examining the moderating role played by the cultural value of uncertainty

Hao-Yi Chen; Henry Shang-Ren Kao

2009-01-01

334

Chinese Thought and Chinese Language: Effects on Students' Writings.  

ERIC Educational Resources Information Center

|Because the conceptual and grammatical constructions of English and Chinese vary drastically, Chinese students often have difficulty learning to think and write in English. Cultural conflicts of young Chinese in America compound their difficulties with the English language. The old values expressed by Chinese affect students' abilities to write…

Lay, Nancy Duke S.

335

Hodgkin's Lymphoma Therapy: Past, Present, and Future  

PubMed Central

Importance of the field The treatment of Hodgkin lymphoma (HL) with the use of radiotherapy and systemic chemotherapy has been one of the success stories of modern oncology. HL therapy has been the paradigm for the systematic evaluation of different curative modalities resulting in cure for the majority of patients. The current focus is on designing initial therapeutic strategies which retain efficacy and minimize long-term toxicity. Appropriate use of pathologic, clinical, biologic and radiologic prognostic factors in identification of aggressive HL is paramount in designing a successful therapeutic strategy. Areas covered in this review This review addresses the current and future use of prognostic tools, including PET scanning and other biomarkers, in identifying patients with aggressive HL with reference to publications from the last two decades. The current standard approaches with the use of combined modality therapy and systemic chemotherapy as well as the promising role of future response-adapted strategies is reviewed. What the reader will gain The reader will obtain a comprehensive review of risk assessment strategies as well as current and investigational therapeutic approaches in the management of HL. Take home message In HL, appropriate utilization of risk assessment strategies is required to maximize therapeutic outcomes while minimizing toxicity, especially long-term toxicity. Response-adapted therapy utilizing PET has the potential to profoundly improve the therapeutic landscape in HL.

Kadin, M; Rathore, B

2010-01-01

336

Management of Stage IIIA Hodgkin's disease  

SciTech Connect

Forty patients with pathological Stage IIIA Hodgkin's disease were allocated to receive either total modal irradiation (TNI) or 6 cycles of chemotherapy with Nitrogen Mustard (Mustine), Vinblastine, Procarbazine and Prednisolone (MVPP) as initial treatment. The complete remission rate for both groups was 100%, with 5-year actuarial disease-free survival figures of 74 and 87% for TNI and MVPP respectively (median duration of follow-up= 48 months). Eighty-eight percent of TNI treated patients were alive at 5 years compared with 100% in the MVPP group. Three patients died, two who were treated with TNI and one who received MVPP. Treatment related morbidity included one patient with osteonecrosis and one with a second malignancy. Given the length of follow-up available, these results demonstrate no significant difference between TNI and MVPP for patients with Stage IIIA disease; it is unlikely that further patient entry into this particular study will allow any conclusion to be reached regarding the optimal form of management. We would recommend that individual disease characteristics within Stage IIIA be used as a basis for future treatment decisions with the understanding that further information regarding morbidity may become available with prolonged follow-up.

Timothy, A.R.; Sutcliffe, S.B.J.; Lister, A.; Wrigley, P.F.M.; Jones, A.E.

1980-02-01

337

Role of radiation therapy in Hodgkin's lymphoma.  

PubMed

Radiation therapy was the first modality that solely cured patients with Hodgkin's lymphoma (HL) as early as the 1940s. In the absence of other curative options, the radiation field in full dose was extended to encompass both involved and uninvolved sites including many normal organs. Decades later, it was evident that some of the HL survivors succumbed to radiation-related effects, mostly second solid tumors. The more recent reliance on modern chemotherapy in combination with radiation yielded further improvement in disease control and allowed a marked reduction in radiation exposure. Some oncologists even suggested that chemotherapy alone might retain the excellent results obtained with combined modality and campaigned for the exclusion of radiotherapy from the treatment program. However, analysis of randomized studies (as discussed later) supports the inclusion of reduced-field and dose radiotherapy in treatment programs for HL. Furthermore, new concerns regarding the short- and long-term safety of enhancing chemotherapy to compensate for the omission of radiotherapy favor shorter courses of chemotherapy. Short chemotherapy supplemented with mini-radiotherapy constitutes a highly effective and safe treatment of HL, particularly in early stages. PMID:19390312

Yahalom, Joachim

338

Diet and non-Hodgkin's lymphoma risk  

PubMed Central

Background The role of dietary factors in the epidemiology of Non-Hodgkin's lymphoma (NHL) remains largely undefined. Dietary habits may play a role in the etiology of NHL by influencing the immune system. Methods Dietary patterns and the risk of NHL were analyzed in a case control study; including 170 NHL cases and 190 controls. All subjects completed a validated food-frequency questionnaire. The dietary pattern was investigated separately and in nine nutritional groups. Crosstab tables were used to estimate the odds ratios (OR), and Ptrend. Results Consumption of highest versus lowest quartile of proteins (OR, 8.088 Ptrend=0.000), fats (OR, 6.17 Ptrend=0.000) and sweets (OR, 8.806 Ptrend=0.000) were associated with a significantly increased NHL risk. The inverse association was found for fresh fruits (OR, 0.117 Ptrend=0.000) and vegetables (OR, 0.461 Ptrend=0.010). Conclusion An association between dietary intake and the risk of NHL is biologically plausible due to immunosuppressive effects of fat and animal proteins, and antioxidant properties of vegetables and fruits.

Mozaheb, Zahra; Aledavood, Amir; Farzad, Farzaneh

2012-01-01

339

Radioimmunotherapy for Non-Hodgkin's Lymphoma  

PubMed Central

Non-Hodgkin’s lymphoma (NHL) is the most common hematological malignancy in the United States with a rapidly increasing incidence. Most follicular NHL is indolent but incurable, whereas the more aggressive varieties do respond to therapy. Most patients with follicular NHL who transform to an aggressive NHL are very difficult to treat successfully. Treatment options have included chemotherapy, radiation, immunotherapy with monoclonal antibodies, alone or in combination, and hematopoietic stem cell transplantation. The efficacy of monoclonal antibodies is augmented when they are combined with a radioisotope like iodine-131 or yttrium-90. There have been a number of studies done in recent years studying the efficacy of this form of therapy, i.e., radioimmunotherapy (RIT) in patients with NHL. This review attempts to integrate the information from the various clinical trials done using RIT in patients with relapsed/refractory or newly diagnosed NHL and in hematopoietic stem cell transplantation. It also includes updates on the use of RIT in elderly patients and in patients with significant bone marrow involvement among other recent advances made in this field.

Rao, Arati V.; Akabani, Gamal; Rizzieri, David A.

2005-01-01

340

The role of chemokines in Hodgkin's disease.  

PubMed

Recent studies have analyzed the expression of chemokines in tissues involved by Hodgkin's disease (HD) (1). The data indicate a significant role for chemokine expression in the pathobiology and pathophysiology of HD. In general, HD tissues showed higher levels of chemokine expression than reactive lymphoid hyperplasia (RLH) tissues. There were major differences in chemokine expression among the different HD subtypes. Similar to previous studies in athymic mice that identified a pattern of chemokine response induced by Epstein-Barr virus (EBV)-infected cells, the expression of IP-10, Mig, RANTES, and MIP1-alpha was higher in EBV positive compared to EBV negative HD tissues. In addition, there was a direct correlation of eotaxin expression with tissue eosinophilia. By immunohistochemistry, IP-10 and Mig proteins localized in the malignant Reed-Steinberg (RS) cells and their variants, and to some surrounding inflammatory cells. Eotaxin localized to fibroblasts and smooth muscle of blood vessels. In this review, we discuss the patterns of expression of IP-10, Mig, RANTES, MIP1-alpha, and eotaxin in HD and its subtypes, and the relationship to EBV positivity, LMP1 expression, tissue eosinophilia and T cell infiltration. In addition, we discuss the potential role of chemokines and cytokines in the pathobiology of HD. PMID:10830743

Teruya-Feldstein, J; Tosato, G; Jaffe, E S

2000-07-01

341

Hodgkin's disease with bone marrow involvement.  

PubMed

Bone marrow involvement was seen in 11 percent of patients with Hodgkin's Disease which was determined from pre-treatment biopsy specimens using established histopathologic criteria. Analysis of 32 evaluable patients with marrow involvement showed male preponderance with a peak in fourth decade of life. Twenty four cases (75%) had B-symptoms and 15 (46%) presented within six months of onset of symptoms. On categorizing for clinical staging, 21 (65%) belonged to stage III and IV. Hepatomegaly (greater than or equal to 2 cms) was present in seven cases (21%) and splenomegaly in 13 cases (40%). Mixed cellularity and lymphocytic depletion histopathologic subtypes showed the highest frequency of involvement (21 cases; 65%). Out of 28 cases ESR was raised in 27 cases (96%). Eighteen cases (56%) showed elevated serum alkaline phosphatase levels. Serum copper levels were determined in 14 cases, out of which 12 (85%) showed elevated levels. These parameters along with anemia (hemoglobin of 12 g/dl or less) in 26 cases (81%), correlated well with the disease activity. Only four cases had leukopenia at presentation pointing to no hindrance for aggressive chemotherapy. All cases received minimum of six courses of standard combination chemotherapy with or without local radiotherapy. Sixteen cases (50%) relapsed subsequently and were managed accordingly. A five year follow-up revealed a minimal 31 percent overall survival, and 18 percent of patients were disease free and well since the time of treatment.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:2591999

Gupta, R; Parikh, P M; Advani, S H; Charak, B S; Saikia, T; Dinshaw, K A; Gonsalves, M A; Gopal, R; Nair, C N; Nadkarni, K S

1989-06-01

342

Staging laparotomy in non-Hodgkin's lymphomata.  

PubMed Central

Staging laparotomy was performed in 106 selected untreated adults and in 6 children. In adults the histological pattern at initial biopsy was interpreted as nodular lymphoma in 33% and as diffuse lymphoma in 67%. Diffuse histiocytic was the most frequently observed histological subtype in the present series (54%). Diffuse undifferentiated lymphoma was noted in 2/6 children. Waldeyer's ring involvement was noted in 27% of adult patients. Systemic symptoms were present in 7%. Surgery detected occult lesions in 27% of patients (para-aortic nodes 3%, spleen 12%, liver 12%, coeliac nodes 15%, splenic hilar nodes 26%, mesenteric nodes 15%, gastrointestinal tract 1%, bone marrow 12%). The chance of detecting splenic and hepatic involvement was definitely higher in patients with nodal disease above and below the diaphragm in comparison with those with either supra-diaphragmatic or infra-diaphragmatic adenopathy. Lymphography yielded a 96% accuracy proving once more to be a sufficiently reliable diagnostic method. Staging laparotomy is a useful procedure in non-Hodgkin's lymphomata in order to gain information on the natural history and to plan treatment. It remains to be determined whether findings observed through surgical staging will lead to improved treatment and survival.

Bonadonna, G.; Pizzetti, F.; Musumeci, R.; Valagussa, P.; Banfi, A.; Veronesi, U.

1975-01-01

343

Chinese culture and social work  

Microsoft Academic Search

The aim of this article is to assist social workers to work with people of Chinese background. The paper is in four parts. Firstly there is an overview of the Chinese community of Australia. This is followed by a description of the main features of traditional Chinese cultural beliefs. Thirdly the human service needs of Chinese people are discussed. Finally

Jennifer Martin

1998-01-01

344

Preparing for Chinese New Year.  

ERIC Educational Resources Information Center

This is one of a series of elementary readers written in Cantonese and English, designed to familiarize children with the traditional major Chinese festivals celebrated by the Chinese in America. The booklet follows the activities of a Chinese-American family in its preparations for the Chinese New Year. (CLK)

Lew, Gordon

345

Preparing for Chinese New Year.  

ERIC Educational Resources Information Center

|This is one of a series of elementary readers written in Cantonese and English, designed to familiarize children with the traditional major Chinese festivals celebrated by the Chinese in America. The booklet follows the activities of a Chinese-American family in its preparations for the Chinese New Year. (CLK)|

Lew, Gordon

346

Breast cancer after treatment of Hodgkin's lymphoma: general review.  

PubMed

The improved survival rates among patients with Hodgkin's lymphoma over the past few decades have come with increased incidence of second malignancies. One of the major concerns among female survivors is the significantly elevated risk of breast cancer that appears with extended follow-up. In this review, we include the published literature regarding the risk of breast cancer after irradiation for Hodgkin's lymphoma. We also present the possible long-term surveillance strategies and the optimal time to start screening these women. This could potentially help in early detection of secondary breast cancers and consequently improve outcomes. Furthermore, because of prior radiotherapy, the management of the breast cancer among this unique population has been controversial. We discuss the characteristics of breast cancer that occurs after Hodgkin's lymphoma and also treatment options that could be implemented. PMID:19028269

Alm El-Din, Mohamed A; El-Badawy, Samy A; Taghian, Alphonse G

2008-12-01

347

Role of Radiotherapy in Modern Treatment of Hodgkin's Lymphoma  

PubMed Central

Hodgkin's Lymphoma was incurable until the advent of effective therapeutic radiation around the first half of the 20th century. As survival rates improved, the long-term toxicities from radiotherapy began to emerge. This together with the availability of effective chemotherapy has encouraged a combined modality approach for early-staged disease and the omission of radiotherapy in advanced-staged disease. The differing toxicities of radiotherapy and chemotherapy has promoted ongoing research to identify the utility of each of these modalities in the modern management of Hodgkin's Lymphoma. This article will provide a critical review of the developments and indications for modern radiotherapy, in context with advances in chemotherapy, for the treatment of Hodgkin's Lymphoma.

Yeoh, Kheng-Wei; Mikhaeel, N. George

2011-01-01

348

Breast Cancer After Treatment of Hodgkin's Lymphoma: General Review  

SciTech Connect

The improved survival rates among patients with Hodgkin's lymphoma over the past few decades have come with increased incidence of second malignancies. One of the major concerns among female survivors is the significantly elevated risk of breast cancer that appears with extended follow-up. In this review, we include the published literature regarding the risk of breast cancer after irradiation for Hodgkin's lymphoma. We also present the possible long-term surveillance strategies and the optimal time to start screening these women. This could potentially help in early detection of secondary breast cancers and consequently improve outcomes. Furthermore, because of prior radiotherapy, the management of the breast cancer among this unique population has been controversial. We discuss the characteristics of breast cancer that occurs after Hodgkin's lymphoma and also treatment options that could be implemented.

Alm El-Din, Mohamed A. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States); Department of Radiation Oncology, Tanta University Hospitals, Tanta Faculty of Medicine, Tanta (Egypt); El-Badawy, Samy A. [Department of Radiation Oncology, National Cancer Institute, Cairo University, Cairo (Egypt); Taghian, Alphonse G. [Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA (United States)], E-mail: ataghian@partners.org

2008-12-01

349

Vera Peters and the curability of Hodgkin disease  

PubMed Central

The middle of the 20th century hailed the realization that patients with Hodgkin disease could be cured. Through the groundbreaking work of Vera Peters, patients with a localized form of the disorder, previously thought to be incurable, were shown to be cured by extended-field radiotherapy. This important observation, although not immediately accepted, opened the minds of physicians to take more positive investigative and therapeutic approaches. Peters also introduced and championed the concept of tumour staging in Hodgkin disease and the use of prognostic factors in clinical decision-making. This novel approach led to high cure rates with radiotherapy in localized disease and provided a scientific basis for the subsequent use of chemotherapy in disseminated disease, resulting in a very high cure rate in patients with all stages of Hodgkin disease.

Cowan, D.H.

2008-01-01

350

Female reproductive potential after treatment for Hodgkin's disease  

SciTech Connect

The probability of maintaining ovarian function, becoming pregnant, and delivering a normal child is important to young women anticipating successful therapy for Hodgkin's disease. In this study, reproductive function was retrospectively examined in 103 women 40 years old or younger who had undergone treatment for Hodgkin's disease with total-lymphoid irradiation (TLI) alone, combination chemotherapy, or combined TLI and chemotherapy. Infertility was directly related to gonadal exposure to therapy and to age at treatment. Twenty women became pregnant after receiving total-nodal irradiation or combination chemotherapy or both. No fetal wastage occurred, and no birth defects were seen in the 24 infants born to these women. Even after intensive treatment programs, women successfully treated for Hodgkin's disease have become pregnant and delivered phenotypically normal children.

Horning, S.J.; Hoppe, R.T.; Kaplan, H.S.; Rosenberg, S.A.

1981-06-01

351

Hodgkin Lymphoma Untreated for Six Years Presenting with Tracheoesophageal Fistula  

PubMed Central

Hodgkin lymphoma is a highly curable cancer with modern therapy, with five-year survival rates in excess of 80%. However, the natural history of the untreated disease is largely unknown. We present the case of a patient with Hodgkin lymphoma who went untreated for over 5 years due to patient choice. Eventually, the patient developed hypoxemia, significant weight loss, and a tracheoesophageal fistula. After a placement of a gastrostomy tube and tracheal stent, treatment with standard chemotherapy was initiated. The patient achieved an excellent response, the fistula closed without further intervention, and there is no evidence of relapse six years later. Even in a patient with significant Hodgkin-lymphoma-related sequelae, standard therapy can result in excellent long-term outcomes.

Westin, Jason R.; Gibbs, Amye; Mills, Keith R.; Neelapu, Sattva S.

2012-01-01

352

Non-Hodgkin's lymphoma of maxillary sinus: An unusual presentation.  

PubMed

Non-Hodgkin's Lymphoma (NHL) are a group of neoplasms that originate from the cells of the lymphoreticular system. Forty percent of Non-Hodgkin's lymphoma arises from extranodal sites. The nasal cavities and paranasal sinuses are rarely affected by primary NHL. Common primary extranodal sites of lymphomas include stomach, liver, soft tissue, dura, bone, intestine and bone marrow. Most patients present with rapidly enlarging masses, often with symptoms both locally and systemically (fever, recurrent night sweats, or weight loss). The vast majority of patients with localized disease are curable with combined modality therapy or combination chemotherapy alone. About 50% patients are cured with doxorubicin based combination chemotherapy and rituximab. An atypical case of extranodal Non-Hodgkin's lymphoma of maxillary sinus is discussed. PMID:23662270

Adwani, Dwarkadas Gokuldas; Arora, Rajender Singh; Bhattacharya, Anirudh; Bhagat, Bhushan

2013-01-01

353

Non-Hodgkin's lymphoma of maxillary sinus: An unusual presentation  

PubMed Central

Non-Hodgkin's Lymphoma (NHL) are a group of neoplasms that originate from the cells of the lymphoreticular system. Forty percent of Non-Hodgkin's lymphoma arises from extranodal sites. The nasal cavities and paranasal sinuses are rarely affected by primary NHL. Common primary extranodal sites of lymphomas include stomach, liver, soft tissue, dura, bone, intestine and bone marrow. Most patients present with rapidly enlarging masses, often with symptoms both locally and systemically (fever, recurrent night sweats, or weight loss). The vast majority of patients with localized disease are curable with combined modality therapy or combination chemotherapy alone. About 50% patients are cured with doxorubicin based combination chemotherapy and rituximab. An atypical case of extranodal Non-Hodgkin's lymphoma of maxillary sinus is discussed.

Adwani, Dwarkadas Gokuldas; Arora, Rajender Singh; Bhattacharya, Anirudh; Bhagat, Bhushan

2013-01-01

354

ClassicBookshelf.com  

NSDL National Science Digital Library

While there are any number of sites featuring public domain e-texts, this site stands out not so much for its content, but for its innovative Java reading applet. Visitors reading e-texts at this site do not have to settle for a sometimes difficult-to-read default display. Using the applet at the bottom of the viewing window, users can control the text size, font, and background color, picking a combination that makes reading easiest. The works featured at the site are listed by author name (best accessed via the site map link at the top right corner of the page), and include a number of classic works of (primarily) British and American literature, with an especially large collection of works by Charles Dickens. Entries for each author include several related sites (including webrings). From the site map page users can also perform keyword searches of the site's title and author listings, and access bookmarks, a helpful feature that allows readers to save their place in books between visits and return to where they left off.

355

Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells  

Microsoft Academic Search

The origins of the neoplastic cells in Hodgkin's lymphoma1, the Hodgkin (H) and Sternberg-Reed(SR) cells, are still obscure, and these cells appear to carry no markers found on any population of normal cells2,3. However the recent establishment of permanent Hodgkin cell lines3,4 has led to the search for tumour-specific antigens and\\/or for membrane markers on H and SR cells which

Ulrich Schwab; Harald Stein; Johannes Gerdes; Hilmar Lemke; Hartmut Kirchner; Michael Schaadt; Volker Diehl

1982-01-01

356

Subthreshold Oscillatory Responses of the Hodgkin-Huxley Cable Model for the Squid Giant Axon  

PubMed Central

The classical cable equation, in which membrane conductance is considered constant, is modified by including the linearized effect of membrane potential on sodium and potassium ionic currents, as formulated in the Hodgkin-Huxley equations for the squid giant axon. The resulting partial differential equation is solved by numerical inversion of the Laplace transform of the voltage response to current and voltage inputs. The voltage response is computed for voltage step, current step, and current pulse inputs, and the effect of temperature on the response to a current step input is also calculated. The validity of the linearized approximation is examined by comparing the linearized response to a current step input with the solution of the nonlinear partial differential cable equation for various subthreshold current step inputs. All the computed responses for the squid giant axon show oscillatory behavior and depart significantly from what is predicted on the basis of the classical cable equation. The linearization procedure, coupled with numerical inversion of the Laplace transform, proves to be a convenient approach which predicts at least qualitatively the subthreshold behavior of the nonlinear system.

Sabah, N. H.; Leibovic, K. N.

1969-01-01

357

Neutropenia and Neutropenic Complications in ABVD Chemotherapy for Hodgkin Lymphoma  

PubMed Central

A combination of Adriamycin (a.k.a. Doxorubicin), Bleomycin, Vinblastine, and Dacarbazine (ABVD) is the most commonly used chemotherapy regime for Hodgkin lymphoma. This highly effective treatment is associated with a significant risk of neutropenia. Various strategies are adopted to counter this commonly encountered problem, including dose modification, use of colony stimulating factors, and prophylactic or therapeutic use of antibiotics. Data to support these approaches is somewhat controversial, and in keeping with the paucity of definitive evidence, there is a wide disparity in the management of neutropenia in patients receiving ABVD chemotherapy. This paper summarizes the evidence for managing ABVD-related neutropenia during the treatment of Hodgkin lymphoma.

Vakkalanka, Bhanu; Link, Brian K.

2011-01-01

358

Lymphome de Hodgkin: traitement des stades localisés sus-diaphragmatiques  

Microsoft Academic Search

\\u000a Abstract  The risk-adapted therapeutic strategy used for adult patients with Hodgkin’s lymphoma is defined taking into account their\\u000a risk factors and includes standard first-line ABVD chemotherapy. In early-stage supradiaphragmatic disease, 3 chemotherapeutic\\u000a courses are applied for patients without risk factors while 4 courses are used for patients with risk factors, followed by\\u000a a radiation therapy targeting initially involved fields (IFRT) at

C. Fermé

2008-01-01

359

History of Chinese medicinal wine  

Microsoft Academic Search

Chinese medicinal wine is one type of a favorable food-drug product invented by Chinese ancestors for treating and preventing\\u000a diseases, promoting people’s health and corporeity, and enriching people’s restorative culture. In the course of development\\u000a of the millenary-old Chinese civilization, Chinese medicinal wine has made incessant progress and evolution. In different\\u000a historical periods, Chinese medicinal wine presented different characteristics in

Xun-li Xia

360

Immunohistochemical detection of ZAP-70 in 341 cases of non-Hodgkin and Hodgkin lymphoma.  

PubMed

Using immunohistochemical methods, we evaluated zeta-associated protein (ZAP)-70 expression in 341 cases of non-Hodgkin and Hodgkin lymphoma. In B-cell NHL, ZAP-70 was positive in five of six (83%) precursor B-lymphoblastic lymphoma, 11 of 37 (30%) chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), five of 39 (13%) mantle cell lymphoma, one of 12 (8%) Burkitt lymphoma, and one of 12 (8%) nodal marginal zone B-cell lymphoma. In 22 cases of CLL/SLL, seven of nine (78%) with unmutated IgVH genes expressed ZAP-70, compared with one of 13 (8%) with mutated IgVH genes (P=0.0015 Fisher's exact test). ZAP-70 expression was not detected in diffuse large B-cell lymphoma (n=26), extranodal marginal zone B-cell lymphoma of mucosa-associated lymphoid tissue (n=24), follicular lymphoma (n=21), plasma cell myeloma/plasmacytoma (n=10), lymphoplasmacytic lymphoma (n=10), or splenic marginal zone lymphoma (n=6). In T/NK-cell NHL, ZAP-70 was positive in all extranodal natural killer (NK) / T-cell lymphoma, nasal-type (n=6) and enteropathy-type T-cell lymphoma (n=4), four of five (80%) subcutaneous panniculitis-like T-cell lymphoma, six of eight (75%) mycosis fungoides, three of five (60%) precursor T-lymphoblastic lymphoma, 10 of 17 (59%) peripheral T-cell lymphoma, two of four (50%) blastic NK-cell lymphoma, one of three (33%) T-cell prolymphocytic leukemia, 13 of 52 (25%) anaplastic large cell lymphoma, and one of six (17%) angioimmunoblastic T-cell lymphoma. Seven of 12 (58%) cutaneous CD30-positive lymphoproliferative disorders were also ZAP-70-positive. In Hodgkin lymphoma, ZAP-70 was negative in neoplastic cells in all cases tested. ZAP-70 staining in B-cell lymphomas and reactive T cells was predominantly nuclear with variable cytoplasmic staining. By contrast, ZAP-70 staining in T/NK-cell lymphomas was heterogeneous, and a shift from predominantly nuclear to predominantly cytoplasmic staining was observed, particularly in those neoplasms with high-grade morphology. In summary, ZAP-70 is expressed by many lymphoma types, correlates with immunoglobulin heavy-chain variable region gene mutational status in CLL/SLL, and can be detected reliably using immunohistochemical methods. PMID:15133473

Admirand, Joan H; Rassidakis, George Z; Abruzzo, Lynne V; Valbuena, Jose R; Jones, Dan; Medeiros, L Jeffrey

2004-08-01

361

Three cases demonstrating the role of gallium scanning in relapsing Hodgkin's disease and non-Hodgkin lymphoma  

SciTech Connect

Restaging of Hodgkin's disease and non-Hodgkin lymphoma for chemotherapy traditionally requires chest radiograph and abdominal computerized tomogram (CT) for routine follow-up examination. Although gallium scanning has had a poor record in the past, recent studies suggest that improved techniques have given this method high sensitivity. We present three cases in which gallium correctly staged lymphoma that had been missed or misinterpreted by chest radiographs and abdominal CT. Gallium imaging is useful in follow-up of lymphoma patients especially when the CT scan is difficult to interpret.

Zollars, L.E.; Nagel, J.S.; Tumeh, S.S.

1987-10-01

362

Central nervous system Hodgkin’s lymphoma without systemic manifestation: case report and review of the literature  

Microsoft Academic Search

A 66-year-old woman treated for ocular myasthenia gravis with azathioprine for 12 years presented with a left fronto-parietal\\u000a mass. Histology revealed primary Hodgkin’s lymphoma of the central nervous system with CD30, Epstein-Barr virus (EBV) latent\\u000a membrane protein and CD20-positive, CD45 (LCA)-negative Reed-Sternberg cells surrounded by T cells. Moreover, EBV-encoded\\u000a RNA-1 (EBER-1) sequences and a monoclonal rearrangement of the immunoglobulin heavy

U. Herrlinger; K. Klingel; R. Meyermann; R. Kandolf; E. Kaiserling; R. D. Kortmann; A. Melms; M. Skalej; J. Dichgans; M. Weller

2000-01-01

363

Chinese Commercial Negotiating Style.  

National Technical Information Service (NTIS)

This study analyzes Chinese commercial negotiating practices for two reasons. The first is to minimize future misunderstandings in such activities, and the second is to provide guidance for government-to-government negotiations. The research procedure use...

L. Pye

1982-01-01

364

Traditional Chinese Biotechnology  

NASA Astrophysics Data System (ADS)

The earliest industrial biotechnology originated in ancient China and developed into a vibrant industry in traditional Chinese liquor, rice wine, soy sauce, and vinegar. It is now a significant component of the Chinese economy valued annually at about 150 billion RMB. Although the production methods had existed and remained basically unchanged for centuries, modern developments in biotechnology and related fields in the last decades have greatly impacted on these industries and led to numerous technological innovations. In this chapter, the main biochemical processes and related technological innovations in traditional Chinese biotechnology are illustrated with recent advances in functional microbiology, microbial ecology, solid-state fermentation, enzymology, chemistry of impact flavor compounds, and improvements made to relevant traditional industrial facilities. Recent biotechnological advances in making Chinese liquor, rice wine, soy sauce, and vinegar are reviewed.

Xu, Yan; Wang, Dong; Fan, Wen Lai; Mu, Xiao Qing; Chen, Jian

365

Haemoglobin E in Chinese.  

National Technical Information Service (NTIS)

Chemical structure studies were made to identify electrophoretically slow haemoglobin variants obtained from nine Chinese subjects living in Taiwan. The subjects had recent family origins in seven provinces of Mainland China as well as Taiwan. In all nine...

R. Q. Blackwell H. J. Yang C. S. Liu C. C. Wang

1968-01-01

366

Chinese Medical Literature.  

National Technical Information Service (NTIS)

Contents: High tibial osteotomy; An investigation of digoxin radioimmunoassay; Comparative studies on the absorption, distribution and excretion of 14C-gossypol in 4 animal species; Maldimelsu antimicrobial activities; Pharmacognostic study of the Chinese...

1980-01-01

367

Dynamical Symmetries in Classical Mechanics  

ERIC Educational Resources Information Center

|We show how symmetries of a classical dynamical system can be described in terms of operators that act on the state space for the system. We illustrate our results by considering a number of possible symmetries that a classical dynamical system might have, and for each symmetry we give examples of dynamical systems that do and do not possess that…

Boozer, A. D.

2012-01-01

368

Classic African American Children's Literature  

ERIC Educational Resources Information Center

|The purpose of this article is to assert that there are classic African American children's books and to identify a sampling of them. The author presents multiple definitions of the term classic based on the responses of children's literature experts and relevant scholarship. Next, the manner in which data were collected and analyzed in regard to…

McNair, Jonda C.

2010-01-01

369

Quantum mechanics from classical statistics  

SciTech Connect

Quantum mechanics can emerge from classical statistics. A typical quantum system describes an isolated subsystem of a classical statistical ensemble with infinitely many classical states. The state of this subsystem can be characterized by only a few probabilistic observables. Their expectation values define a density matrix if they obey a 'purity constraint'. Then all the usual laws of quantum mechanics follow, including Heisenberg's uncertainty relation, entanglement and a violation of Bell's inequalities. No concepts beyond classical statistics are needed for quantum physics - the differences are only apparent and result from the particularities of those classical statistical systems which admit a quantum mechanical description. Born's rule for quantum mechanical probabilities follows from the probability concept for a classical statistical ensemble. In particular, we show how the non-commuting properties of quantum operators are associated to the use of conditional probabilities within the classical system, and how a unitary time evolution reflects the isolation of the subsystem. As an illustration, we discuss a classical statistical implementation of a quantum computer.

Wetterich, C. [Institut fuer Theoretische Physik, Universitaet Heidelberg, Philosophenweg 16, D-69120 Heidelberg (Germany)], E-mail: c.wetterich@thphys.uni-heidelberg.de

2010-04-15

370

Creating a Chinese \\  

Microsoft Academic Search

This paper analyzes the country-of-origin effects of Chinese brands going international. To approach this topic, the author uses a comparative case study, in which a Chinese manufacturer of white goods, Haier, and a German manufacturer, Miele, serve as examples. Fueled by “China trash†reports in EU and US media, the image of China as country of origin still has a

Cora F. Jungbluth

2010-01-01

371

Negotiation: the Chinese style  

Microsoft Academic Search

Purpose – To examine the nature of Chinese business negotiating style in Sino-Western business negotiations in business-to-business markets involving large industrial projects from a social cultural point of view. Design\\/methodology\\/approach – A conceptual approach developed from personal interviews. Findings – This study reveals that the Chinese negotiator does not possess an absolute negotiating style but rather embraces a mixture of

Tony Fang

2006-01-01

372

Advertising to Chinese children  

Microsoft Academic Search

Purpose – China's youthful advertising industry has changed a lot in little more than a quarter of century. A key for this spectacular growth is the enormous potential of the market for children in China. The paper aims to address this issue. Design\\/methodology\\/approach – The Chinese one-child policy has produced the so-called “Little Emperors factor”: Chinese children determine approximately 68

Marisa Planells Valero

2009-01-01

373

Traditional Chinese Biotechnology  

Microsoft Academic Search

\\u000a The earliest industrial biotechnology originated in ancient China and developed into a vibrant industry in traditional Chinese\\u000a liquor, rice wine, soy sauce, and vinegar. It is now a significant component of the Chinese economy valued annually at about\\u000a 150 billion RMB. Although the production methods had existed and remained basically unchanged for centuries, modern developments\\u000a in biotechnology and related fields

Yan Xu; Dong Wang; Wen Lai Fan; Xiao Qing Mu; Jian Chen

2010-01-01

374

Hodgkin's lymphoma in adolescents treated with adult protocols: a report from the German Hodgkin study group.  

PubMed

PURPOSE The standard of care for adolescent patients with Hodgkin's lymphoma (HL) is undefined, particularly the choice between pediatric and adult protocols. Thus, we compared risk factors and outcome of adolescents and young adults treated within study protocols of the German Hodgkin Study Group (GHSG). PATIENTS AND METHODS Three thousand seven hundred eighty-five patients treated within the GHSG studies HD4 to HD9 were analyzed; 557 patients were adolescents age 15 to 20 years, and 3,228 patients were young adults age 21 to 45 years. Results Large mediastinal mass and involvement of three or more lymph node areas were more frequent in adolescents (P < .001). The incidence of other risk factors did not differ significantly between age groups. With a median observation time of 81 months for freedom from treatment failure (FFTF) and 85 months for overall survival (OS), log-rank test showed no significant differences between age groups regarding FFTF (P = .305) and a superior OS (P = .008) for adolescents. Six-year estimates for FFTF and OS were 80% and 94%, respectively, for adolescents and 80% and 91%, respectively, for young adults. After adjustment for other predictive factors, Cox regression analysis revealed age as a significant predictor for OS (P = .004), with a higher mortality risk for young adults. Secondary malignancies were more common in young adults (P = .037). CONCLUSION Outcome of adolescent and young adult patients treated within GHSG study protocols is comparable. These data suggest that adult treatment protocols exhibit a safe and effective treatment option for adolescent patients with HL. However, longer follow-up, including assessment of late toxicity, is necessary for final conclusions. PMID:19901121

Eichenauer, Dennis A; Bredenfeld, Henning; Haverkamp, Heinz; Müller, Horst; Franklin, Jeremy; Fuchs, Michael; Borchmann, Peter; Müller-Hermelink, Hans-Konrad; Eich, Hans T; Müller, Rolf-Peter; Diehl, Volker; Engert, Andreas

2009-11-09

375

Stage IV and age over 45 years are the only prognostic factors of the International Prognostic Score for the outcome of advanced Hodgkin lymphoma in the Spanish Hodgkin Lymphoma Study Group series.  

PubMed

The International Prognostic Score (IPS) is the most widely used system to date for identifying risk groups for the outcome of patients with advanced Hodgkin lymphoma, although important limitations have been recognized. We analyzed the value of the IPS in a series of 311 patients with advanced classical Hodgkin lymphoma (cHL) (Ann Arbor stage III, IV or stage II with B symptoms and/or bulky masses) treated with first-line chemotherapy including adriamycin (adriamycin, bleomycin, vinblastine, dacarbazine [ABVD] or equivalent variants). In univariate and multivariate analyses, stage IV disease and age ? 45 years were the only factors with independent predictive significance for overall survival (OS) (p = 0.002 and p < 0.001, respectively). Stage IV was still significant for freedom from progression (FFP) (p = 0.001) and age ? 45 years was borderline significant (p = 0.058). IPS separates prognostic groups, as in the original publication, but this is mainly due to the high statistical significance of stage IV and age ? 45 years. Moreover, the combination of these two factors enables a simpler system to be constructed that separates groups with different FFP and OS. In conclusion, in our series, stage IV and age ? 45 years are the key prognostic factors for the outcome of advanced cHL. PMID:22185637

Guisado-Vasco, Pablo; Arranz-Saez, Reyes; Canales, Miguel; Cánovas, Araceli; Garcia-Laraña, José; García-Sanz, Ramón; Lopez, Andrés; López, José Luis; Llanos, Marta; Moraleda, José Maria; Rodriguez, José; Rayón, Consuelo; Sabin, Pilar; Salar, Antonio; Marín-Niebla, Ana; Morente, Manuel; Sánchez-Godoy, Pedro; Tomás, José Francisco; Muriel, Alfonso; Abraira, Victor; Piris, Miguel A; Garcia, Juán F; Montalban, Carlos

2012-01-31

376

B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma.  

PubMed

In some instances, the overlap in morphologic features and antigen expression between nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) and classical Hodgkin lymphoma (cHL) can cause confusion in the diagnosis. In these cases, the transcription factors (TFs) B-cell specific activator protein (BSAP)/Pax-5, octamer binding protein-2 (Oct-2), B-lymphocyte-specific co-activator BOB.1/OBF.1, Bcl-6 protein and multiple myeloma-1/interferon regulatory factor-4 (MUM1/IRF-4) may aid in clarifying the diagnosis. Twenty-two cases of NLPHL were studied for the immunohistochemical expression of Pax-5, Oct-2, BOB.1, Bcl-6 protein and MUM1/IRF-4. Our results sustain the usefulness of the selected set of TFs to diagnose and distinguish NLPHL from cHL since Pax-5, Oct-2, BOB.1 and Bcl-6 are consistently expressed by lymphocyte predominant (LP) cells and reported by others to be often unexpressed in Hodgkin and Reed-Sternberg cells. By contrast, MUM1/IRF-4 protein scored negative in the majority of LP cells, but is reported to be expressed in almost all cases of cHL. Thus, although the expression of transcription factors is very heterogeneous, their simultaneous implementation for positive and differential diagnosis may be useful. PMID:21424034

Herbeck, Rosemarie; Teodorescu Brînzeu, D; Giubelan, Marioara; Laz?r, Elena; Dema, Alis; Ioni??, Hortensia

2011-01-01

377

Measles virus: evidence of an association with Hodgkin's disease  

Microsoft Academic Search

The quest for an infectious agent that may account for cases of Hodgkin's disease (HD) especially in young adults has proven vain until lately. We have recently reported findings that suggested the presence of measles virus (MV) antigens and MV RNA in the tissues of patients with HD. Support for an association between MV and HD has been provided by

D Benharroch; Y Shemer-Avni; Y-Y Myint; A Levy; E Mejirovsky; I Suprun; Y Shendler; I Prinsloo; S Ariad; B Rager-Zisman; M Sacks; J Gopas

2004-01-01

378

Immune Response Genotypes and Risk of Young Adult Hodgkin Lymphoma.  

National Technical Information Service (NTIS)

Hodgkin lymphoma (HL) is the first and second most common cancer among young women and men 20-39 years old, respectively. Our previous results from a small twin study suggested that an inherited imbalance in the immune response to infection could increase...

B. Nathwani D. Conti D. Vandenberg V. Cortessis W. Cozen

2008-01-01

379

Incidence of homogeneously staining regions in non-Hodgkin lymphomas  

Microsoft Academic Search

We report a series of 86 non-Hodgkin's lymphomas (NHL) studied cytogenetically in which two cases with a homogeneously staining region (HSR) located on chromosome 19 and on chromosome 1, respectively, were observed. The low incidence detected (2.3%) suggests that HSR are rare events in NHL. An oncogenetic amplification study was performed with probes for genes that are currently known to

E. Arranz; M. Robledo; B. Martínez; J. Gallego; A. Román; C. Rivas; J. Benítez

1996-01-01

380

Autologous stem cell transplantation for advanced Hodgkin's disease in children  

Microsoft Academic Search

This study evaluates the outcome of myeloablative chemo-radiotherapy and autologous stem cell transplantation (ASCT) in children with Hodgkin's disease (HD). Twenty children aged 5 to 18 years (median 10.8 years) at diagnosis, with relapsed, refractory or very poor prognosis HD, underwent ASCT in eight hospitals of our country. Status at transplant was: second complete remission (CR2): n = 12; further

A Verdeguer; N Pardo; L Madero; A Martinez; E Bureo; JM Fernández; A Muñoz; T Olivé; R Fernández-Delgado; J Cubells; MA Diaz; A Sastre

2000-01-01

381

Results of radiotherapy for Stage I and II Hodgkin's disease  

SciTech Connect

Fifty-six patients with pathologically Staged I and II (A and B) Hodgkin's disease were treated with radiation therapy. Three-year relapse-free survival, total survival, and complications were analyzed. Chemotherapy was valuable as rescue treatment and as part of the initial treatment in patients with Stage IIB disease. Complications were minimal.

Lowery, G.S.; Ferree, C.R.; Raben, M.

1982-06-01

382

Results of radiotherapy for stage I and II Hodgkin's disease  

SciTech Connect

Fifty-six patients with pathologically staged I and II (A and B) Hodgkin's disease were treated with radiation therapy. Three-year relapse-free survival, total survival, and complications were analyzed. Chemotherapy was valuable as rescue treatment and as part of the initial treatment in patients with stage IIB disease. Complications were minimal.

Lowery, G.S.; Ferree, C.R.; Raben, M.

1982-06-01

383

Hodgkin's Disease in the U.S. Navy.  

National Technical Information Service (NTIS)

U.S. Naval personnel are involved in a wide variety of occupational specialities which may involve exposure to agents implicated in the development of Hodgkin's disease. Other aspects of naval life-style foster the spread of infectious diseases and increa...

F. C. Garland E. D. Gorham C. F. Garland

1984-01-01

384

INVERSE PROBLEMS FOR THE HODGKIN-HUXLEY MODEL  

Microsoft Academic Search

Inverse problems for the Hodgkin-Huxley equation are examined. To understand functions of a single neuron, such as propagation and generation of synaptic or action potentials, a detailed description of the kinetics of the underlying ionic conductance is essential. In neocor- tical neurons, network activity can activate a large number of synaptic inputs, resulting in highly irregular subthreshold membrane potential uctuations,

MASAYOSHI KUBO

2005-01-01

385

Bifurcation control of the Hodgkin–Huxley equations  

Microsoft Academic Search

The Hodgkin–Huxley equations (HH) are parameterized by a number of parameters and show a variety of qualitatively different behaviors. This paper finds that when the externally applied current Iext varies the bifurcation would occur in the HH equations. The HH model’s Hopf bifurcation is controlled by permanent or interval Washout filters (WF), which can transform the subcritical bifurcations into supercritical

Jiang Wang; Liangquan Chen; Xianyang Fei

2007-01-01

386

Coherence resonance in a Hodgkin-Huxley neuron  

Microsoft Academic Search

We study the nonlinear response of the Hodgkin-Huxley model without external periodic signal to the noisy synaptic current near the saddle-node bifurcation of limit cycles. The coherence of the system, estimated from the interspike interval histogram and from the power spectra of membrane potentials and spike trains, is maximal at a certain noise intensity, so that the coherence resonance occurs.

Sang-Gui Lee; Alexander Neiman; Seunghwan Kim

1998-01-01

387

Survivors of Hodgkin Lymphoma May Face Increased Risk of Stroke  

Cancer.gov

Patients who receive radiation therapy for Hodgkin lymphoma may be at increased risk of a stroke or transient ischemic attack (TIA), also called a "mini stroke," later in life, according to a report in the July 1, 2009, Journal of the National Cancer Institute.

388

CT of Renal and Perirenal Non-Hodgkin Lymphoma  

Microsoft Academic Search

The CT findings from a retrospective review of 16 patients (32 kidneys) with non- Hodgkin lymphoma involving the kidney are presented. In all cases, computed tomog- raphy (CT) accurately depicted the presence, location, and size of the renal lesions and provided information about the adjacent retroperitoneum. CT was helpful in evaluating the course of the disease and its response to

Syed Zafar; Hasan Jafri; Marco A. Amendola; Gary M. Glazer; Richard E. Schwab; Isaac R. Franci; Gil Borlaza

389

Thresholds and Plateaus in the Hodgkin-Huxley Nerve Equations  

Microsoft Academic Search

ABS TR ncT Phase space methods and an analog computer are used to analyze the Hodgkin-Huxley non-linear differential equations for the squid giant axon membrane. V is the membrane potential, m the Na + activation, h the Na + inactivation, and n the K + activation. V and m change rapidly, relative to h and n. The (11, m) phase

RICHARD FITZHUGH

1960-01-01

390

Non-Hodgkin's lymphoma of the adrenal gland.  

PubMed

Primary non-Hodgkin's lymphoma of the adrenal gland was diagnosed in a 64-year-old woman. The histologic and immunohistologic features are characteristic of a large-cell noncleaved lymphoma (B-cell origin). The patient died 3 weeks after right-sided adrenalectomy. The patient's family refused an autopsy. PMID:2198005

Choi, C H; Durishin, M; Garbadawala, S T; Richard, J

1990-08-01

391

Smoking and Hodgkin Lymphoma Risk in Women United States  

Microsoft Academic Search

Objective: Smoking has received little consideration as a risk factor for Hodgkin lymphoma (HL) in women, despite recent significant findings in men and gender differences in HL incidence. We investigated the association of HL with lifetime cigarette smoking and household environmental tobacco smoke (ETS) exposure in women.

Sally L. Glaser; Theresa H. M. Keegan; Christina A. Clarke; Lyndsey A. Darrow; Scarlett L. Gomez; Ronald F. Dorfman; Risa B. Mann; Joseph A. DiGiuseppe; Richard F. Ambinder

2004-01-01

392

Contiguous pattern spreading in patients with Hodgkin's disease  

Microsoft Academic Search

Background: In 1966, Rosenberg and Kaplan hypothesized that Hodgkin's disease (HD) arises at a discrete primary site and subsequently spreads in a predictable manner via functionally contiguous lymph nodes. However, their results were not statistically evident. It was our aim to describe the spreading in the lymphatic system more precisely and to confirm their postulate.Methods: Between 1971 and 1992, 297

Stephan Ludwig Roth; Horst Sack; Klaus Havemann; Reinhart Willers; Béla Kocsis; Viola Schumacher

1998-01-01

393

Nucleoli and AgNORs in Hodgkin's disease.  

PubMed Central

AIM: To evaluate the morphofunctional characteristics of lymph node cells from patients with Hodgkin's disease by measuring silver stained nucleolar organiser regions (AgNORs). METHODS: Nucleoli in Hodgkin's and Reed-Sternberg (HRS) cells, lymphocytes and prolymphocytes were investigated in cytological smears and histological sections of lymph nodes from 32 patients with Hodgkin's disease, and from 34 patients with reactive lymphadenopathy. According to the Rye histological classification of Hodgkin's disease, three cases were the lymphocyte predominant (LP) type, 14 the nodular sclerosing (NS) type, and 15 the mixed cellularity (MC) type. The investigation was done before treatment, by means of a one step silver staining method. In each case, 50 to 100 HRS cells, lymphocytes, and prolymphocytes were evaluated to determine the mean numbers of nucleoli and AgNORs per nucleus. The nonparametric Wilcoxon Mann-Whitney test was used to compare the groups. RESULTS: The mean numbers of nucleoli and AgNORs were higher in lymphocytes and prolymphocytes compared with those from reactive lymph nodes used as controls. Numbers of nucleoli and AgNORs were higher (not significant) in the NS type of Hodgkin's disease than in the MC type. There was a significant increase in numbers of nucleoli in HRS cells, and their AgNOR counts were increased. The greatest number of nucleoli in HRS cells was found in the NS type. Furthermore, the nucleolar activity of HRS cells was greater in the NS type compared with the MC type (50.2 (SEM 3.9) v 37.7 (2.9) AgNORs per nucleus (p = 0.025)). Comparative analysis of cytological and histological samples showed that the AgNOR score was significantly higher in touch imprints than in tissue sections with tumours of the same histological type. CONCLUSIONS: Assessment of cell activity in Hodgkin's disease patients by silver staining is more convenient and informative in lymph node imprints than in histological sections. The highest expression of interphase ribosomal RNA cistrons found in NS HRS cells is probably explained by their high proliferative activity and elevated production of transforming growth factor 1 which is known to be the most potent cytokine present in the NS subtype of Hodgkin's disease. Images

Mamaev, N. N.; Medvedeva, N. V.; Shust, V. F.; Markochev, A. B.; Pasternak, N. D.

1997-01-01

394

Profiles of traditional Chinese medicine schools.  

PubMed

Many schools of academic doctrines have emerged throughout the development history of traditional Chinese medicine (TCM) due to geographic, time, Shicheng (mentor-apprentice system) and academic diversities. Classic TCM School, Classic Formula School and Febrile Disorder School, though all lacking a clearly demonstrable or continuous Shicheng relationship, are nevertheless so classified because of their consistency in reference to the classic TCM works. Each of the Four Famous Masters of Jin and Yuan Dynasties had its distinctively different academic doctrine, resulting in the establishment of individually integrated academic schools. The emergence of the Warming and Tonifying School in late Yuan and early Ming Dynasties was realized as a means to rectify the ill effects of the cool and cold medications prevalent at the time. On the other hand, the advent of the Warm Disease School and the rise of the Confluence School embodied the close relationship carried by TCM academic schools to contemporary historical background. Looking at this development history, it is evident that the development of TCM academic schools could flourish only if it allows dissenting, yet mutually tolerant, opinions. In present medical environment where TCM and Western medicine are of equal importance, Classic TCM Schools, TCM Modernization Schools and Integrative Medicine Schools should all receive emphasis to foster development. PMID:22772917

Chen, Ke-Ji; Xie, Yuan-Hua; Liu, Yue

2012-07-07

395

An audible China: Speech and the innovation in modern Chinese writing  

Microsoft Academic Search

The image of an “audible China” is one opposed to the traditional China’s as “voiceless.” Not only does it refer to the survival\\u000a of modern Chinese out of the abandoned Classical Chinese, it also provides a new means to examine modern China’s cultural\\u000a transformation and development in terms of “voice.“ This essay will discuss mainly how speech, one of “the

Pingyuan Chen

2009-01-01

396

Origin and pathogenesis of nodular lymphocyte-predominant Hodgkin lymphoma as revealed by global gene expression analysis  

PubMed Central

The pathogenesis of nodular lymphocyte–predominant Hodgkin lymphoma (NLPHL) and its relationship to other lymphomas are largely unknown. This is partly because of the technical challenge of analyzing its rare neoplastic lymphocytic and histiocytic (L&H) cells, which are dispersed in an abundant nonneoplastic cellular microenvironment. We performed a genome-wide expression study of microdissected L&H lymphoma cells in comparison to normal and other malignant B cells that indicated a relationship of L&H cells to and/or that they originate from germinal center B cells at the transition to memory B cells. L&H cells show a surprisingly high similarity to the tumor cells of T cell–rich B cell lymphoma and classical Hodgkin lymphoma, a partial loss of their B cell phenotype, and deregulation of many apoptosis regulators and putative oncogenes. Importantly, L&H cells are characterized by constitutive nuclear factor ?B activity and aberrant extracellular signal-regulated kinase signaling. Thus, these findings shed new light on the nature of L&H cells, reveal several novel pathogenetic mechanisms in NLPHL, and may help in differential diagnosis and lead to novel therapeutic strategies.

Brune, Verena; Tiacci, Enrico; Pfeil, Ines; Doring, Claudia; Eckerle, Susan; van Noesel, Carel J.M.; Klapper, Wolfram; Falini, Brunangelo; von Heydebreck, Anja; Metzler, Dirk; Brauninger, Andreas; Hansmann, Martin-Leo; Kuppers, Ralf

2008-01-01

397

Positron emission tomography response at the time of autologous stem cell transplantation predicts outcome of patients with relapsed and/or refractory Hodgkin's lymphoma responding to prior salvage therapy  

PubMed Central

Background High-dose chemotherapy followed by autologous stem cell transplantation is the standard treatment for relapsed and/or refractory Hodgkin’s lymphoma although half of patients relapse after transplantation. Predictive factors, such as relapse within 12 months, Ann-Arbor stage at relapse, and relapse in previously irradiated fields are classically used to identify patients with poor outcome. Recently, 18-fluorodeoxyglucose positron emission tomography has emerged as a new method for providing information to predict outcome. The aim of this study was to confirm the predictive value of positron emission tomography status after salvage therapy and to compare single versus tandem autologous stem cell transplantation in patients with relapsed and/or refractory Hodgkin’s lymphoma. Design and Methods We report a series of 111 consecutive patients with treatment-sensitive relapsed and/or treatment-refractory Hodgkin’s lymphoma who achieved complete (positron emission tomography-negative group) or partial remission (positron emission tomography-positive group) at positron emission tomography evaluation after salvage chemotherapy and who underwent single or tandem autologous stem cell transplantation. Results Five-year overall and progression-free survival rates were 81% and 64%, respectively. There were significant differences in 5-year progression-free survival (79% versus 23%; P<0.001) and 5-year overall survival (90% versus 55%, P=0.001) between the positron emission tomography-negative and -positive groups, respectively. A complete response, as determined by positron emission tomography evaluation, after salvage therapy predicted significantly better 5-year overall survival rates in both intermediate (91% versus 50%; P=0.029) and unfavorable (89% versus 58%; P=0.026) risk subgroup analyses. In the positron emission tomography-positive subgroup, tandem transplantation improved 5-year progression-free survival from 0% (in the single transplantation group) to 43% (P=0.034). Multivariate analysis showed that positron emission tomography status (hazard ratio: 5.26 [2.57–10.73]) and tandem transplantation (hazard ratio: 0.39 [0.19–0.78]) but not risk factors at relapse (hazard ratio: 1.77 [0.80–3.92]) significantly influenced progression-free survival, while only tomography status significantly influenced overall survival (hazard ratio: 4.03 [1.38–11.75]). Conclusions In patients with relapsed/refractory Hodgkin’s lymphoma responding to prior salvage therapy, positron emission tomography response at time of autologous stem cell transplantation favorably influences outcome and enables identification of patients requiring single or tandem transplantation.

Devillier, Raynier; Coso, Diane; Castagna, Luca; Brenot Rossi, Isabelle; Anastasia, Antonella; Chiti, Arturo; Ivanov, Vadim; Schiano, Jean Marc; Santoro, Armando; Chabannon, Christian; Balzarotti, Monica; Blaise, Didier; Bouabdallah, Reda

2012-01-01

398

Non-Hodgkin's lymphomas in U.S. Navy personnel.  

PubMed

Non-Hodgkin's lymphomas are one of the most commonly occurring cancers in the age groups heavily represented in the U.S. Navy. The Navy has a wide range of potential occupational exposures. This study was initiated to identify any occupational associations of non-Hodgkin's lymphomas that may adversely affect naval readiness. The objective of this study was to compare the incidence of non-Hodgkin's lymphomas in U.S. Navy active duty enlisted personnel during the period 1974-1983 with the general U.S. population, and to assess if risk varied by naval occupation or length of service. The Naval Health Research Center's computer-based disease registry was used to conduct a prospective study of all white U.S. Navy enlisted men during 1974-1983 to test for the existence of any short-term risk possibly due to occupation. Men in 80 occupations, ranging from clerk to journalist to machinist and boiler operator were observed for 3,704,864 person-years; mean length of service was 5.1 yr, but 19% of person-years were contributed by men who had served at least 11 yr. Incident cases of non-Hodgkin's lymphomas were identified and verified using Medical Board findings or review of original medical records. Average annual age-specific and age-adjusted incidence rates were calculated. Examination of pathology records and medical review boards confirmed 68 cases of non-Hodgkin's lymphomas. The annual age-adjusted incidence rate per 100,000 person-years in Navy men was significantly lower than in the U.S. Surveillance, Epidemiology, and End Results (SEER) population, probably due to screening and other selection factors associated with Navy service that result in a healthy worker effect.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:3196078

Garland, F C; Gorham, E D; Garland, C F; Ferns, J A

399

Chinese health beliefs of older Chinese in Canada.  

PubMed

Objectives. This study examines the cultural health beliefs held by older Chinese in Canada. Methods. Chinese surnames are randomly selected from the local Chinese telephone directories. Telephone screening is then conducted to identify eligible Chinese people 55 years of age or older to take part in a face-to-face interview to complete a structured survey questionnaire. Results. The results of exploratory factor analysis indicate that the health beliefs of the older Chinese are loaded onto three factors related to beliefs about traditional health practices, beliefs about traditional Chinese medicine, and beliefs about preventive diet. Education, religion, country of origin, length of residency in Canada, and city of residency are the major correlates of the various Chinese health beliefs scales. Discussion. The findings support the previous prescriptive knowledge about Chinese health beliefs and illustrate the intragroup sociocultural diversity that health practitioners should acknowledge in their practice. PMID:19144968

Lai, Daniel W L; Surood, Shireen

2009-02-01

400

Clustering of cancer among families of cases with Hodgkin Lymphoma (HL), Multiple Myeloma (MM), Non-Hodgkin's Lymphoma (NHL), Soft Tissue Sarcoma (STS) and control subjects  

Microsoft Academic Search

BACKGROUND: A positive family history of chronic diseases including cancer can be used as an index of genetic and shared environmental influences. The tumours studied have several putative risk factors in common including occupational exposure to certain pesticides and a positive family history of cancer. METHODS: We conducted population-based studies of Hodgkin lymphoma (HL), Multiple Myeloma (MM), non-Hodgkin's Lymphoma (NHL),

Helen H McDuffie; Punam Pahwa; Chandima P Karunanayake; John J Spinelli; James A Dosman

2009-01-01

401

Stage-related changes in functional capacity in Hodgkin’s disease: assessment by cardiopulmonary exercise testing before initiation of treatment  

Microsoft Academic Search

Our aim was to examine indices of cardiorespiratory capacity at rest and during exercise before initiation of therapy for Hodgkin’s disease. We prospectively studied 24 patients divided into two groups according to the disease stage. Group 1 included eight patients in stage IA and four in stage IIA; group 2 included four patients in stage IIB, six in stage III,

Eric Page; David Assouline; Catherine Durand; Odile Brun; David Coeffic; Danièle Fric; Claire Garnier; Cécile Leyronnas; Véronique Alcalay; Bernard Aguilaniu

2006-01-01

402

Hodgkin and Reed-Sternberg Cells in Lymphocyte Predominant Hodgkin Disease Represent Clonal Populations of Germinal Center-Derived Tumor B Cells  

Microsoft Academic Search

Among the four subtypes of Hodgkin disease (HD), lymphocyte-predominant (LP) HD is now generally considered as a separate entity. The B cell nature of the typical Hodgkin and Reed-Sternberg (HRS) cells and their variants (L and H, lymphocytic and histiocytic cells) in LP HD has long been suspected, but the question of whether these cells represent a true tumor clone

Andreas Braeuninger; Ralf Kuppers; John G. Strickler; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann

1997-01-01

403

Teaching Chinese Negotiating Style through Examination of Key Chinese Categories.  

ERIC Educational Resources Information Center

|This study examined different shades of meaning that a single word may have in Chinese in an effort to better understand the relationship between language and culture. An understanding of the exact meaning of Chinese words and expressions can greatly assist non-Chinese in understanding both the language and the society as a whole. A total of 102…

Myers, Dan

404

The Chinese Finger Alphabet and the Chinese Finger Syllabary.  

ERIC Educational Resources Information Center

|Describes two manual aids used in educating deaf children in Peking: the Chinese finger alphabet for teaching Chinese characters, and a new device being experimented with called the Chinese finger syllabary. Sample illustrations are given for both, as well as for the Pinyin finger alphabet. (PJM)|

Youguang, Zhou

1980-01-01

405

Factors affecting physician visits in Chinese and Chinese immigrant samples  

Microsoft Academic Search

This study examines predictors of Western physician utilization using the Andersen's Behavioral Model of Health Services Use for Chinese elders who reside in Shanghai and immigrant Chinese elders who reside in the US Chinese elders are under-studied relative to their population size and in the US are known to underutilize the healthcare system. Underutilization is highly correlated with poor health

Helen B. Miltiades; Bei Wu

2008-01-01

406

Health Information in Chinese - Simplified (????): MedlinePlus  

MedlinePLUS

... Bilingual Chinese Community Health Resource Center Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Simplified) PDF Chinese Community ... Chinese Community Health Resource Center Diets Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Simplified) PDF Chinese Community ...

407

Health Information in Chinese - Traditional (????): MedlinePlus  

MedlinePLUS

... PDF Chinese Community Health Resource Center Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Traditional) PDF Chinese Community ... Chinese Community Health Resource Center Diets Low Fat, Low Cholesterol Diet - English ????????? - ???? (Chinese - Traditional) PDF Chinese Community ...

408

Classical Foundations: Leah Rochel Johnson  

ERIC Educational Resources Information Center

|This article discusses the accomplishments of Leah Rochel Johnson, Assistant Professor of Classics and Ancient Mediterranean Studies and History, Pennsylvania State University. It provides insight into her values and beliefs and testimony from those who work most closely with her.|

Lum, Lydia

2005-01-01

409

Neuronal Model of Classical Conditioning.  

National Technical Information Service (NTIS)

The neuronal model of classical conditioning is proposed to yield a model more in accordance with animal learning phenomena. Instead of correlating pre- and postsynaptic levels of activity, changes in pre- and postsynaptic levels of activity should be cor...

A. H. Klopf

1987-01-01

410

Classical Foundations: Leah Rochel Johnson  

ERIC Educational Resources Information Center

This article discusses the accomplishments of Leah Rochel Johnson, Assistant Professor of Classics and Ancient Mediterranean Studies and History, Pennsylvania State University. It provides insight into her values and beliefs and testimony from those who work most closely with her.

Lum, Lydia

2005-01-01

411

Data mining and Chinese medicine  

Microsoft Academic Search

By using data mining techniques, we are• Searching active ingredients (herbs or chemical compounds) in the effective prescriptions of Chinese medicine for specific diseases;• Identifying Chinese medicine material by their \\

Josef Siu-wai Leung

1998-01-01

412

Ethnography of a Chinese community  

Microsoft Academic Search

Cornelius Osgood. The Chinese: A Study of a Hong Kong Community. Tucson: The University of Arizona Press, 1975. Three Volumes, xviii + 1264 pp. Illustrations, figures, tables, maps, list of Chinese characters, bibliography, and index. $45.00.

E. N. Anderson Jr

1977-01-01

413

The Early Chinese Canadians  

NSDL National Science Digital Library

This bilingual website offered by the Library and Archives of Canada (LAC) explores Canada's early Chinese immigrants, covering the period 1858 to 1947. To learn why the Chinese immigrated to Canada, visitors should click on "The History" on the far left side of the page. Once there, visitors can choose from several specific sections to read about, including "Working in B.C.: Gold, Railway, Mining and Salmon", "Racism and Law in Society", and "Communities for Canada and China". Additionally, each contains suggestions for further reading on the subject for both adults and children. Visitors who desire to browse photos and documents can click on "Historical Photographs and Documents" on the far left side of the page. There are three sections, "Research Guide", "Gallery of Documents", and "Gallery of Photographs". The Research Guide provides a thorough explanation on how to research the "photographs, artwork, published books, personal archives, and, in particular, government records" of Chinese Canadians, which are dispersed throughout the LAC collection. The documents and photographs galleries allow visitors to view, and even order, a print or digital copy of the historic materials. Finally, the "Head Tax Records" link located on the far left side of the page, allows visitors to search for Chinese immigrants to Canada that were recorded in the General Registers of Chinese Immigration. Visitors can search these registers online by the person's name, arrival year, or certificate number. [KMG

414

Ancient Chinese Astronomical Technologies  

NASA Astrophysics Data System (ADS)

I am interested in the astronomical advances of the Ancient Chinese in measuring the solar day. Their development of gnomon & ruler, sundial, and water clock apparatuses enabled Chinese astronomers to measure the annual solar orbit and solar day more precisely than their contemporaries. I have built one of each of these devices to use in collecting data from Olympia, Washington. I will measure the solar day in the Pacific Northwest following the methodology of the ancient Chinese. I will compare with my data, the available historical Chinese astronomical records and current records from the United States Naval Observatory Master Clock. I seek to understand how ancient Chinese investigations into solar patterns enabled them to make accurate predictions about the movement of the celestial sphere and planets, and to develop analytic tests of their theories. Mayall, R. Newton; Sundials: their construction and use. Dover Publications 2000 North, John; The Norton History of Astronomy and Cosmology W.W. Norton& Co. 1995 Zhentao Xu, David W. Pankenier, Yaotiao Jiang; East Asian archaeoastronomy : historical records of astronomical observations of China, Japan and Korea Published on behalf of the Earth Space Institute by Gordon and Breach Science Publishers, c2000

Walsh, Jennifer Robin

2004-05-01

415

Elements of Classical Knot Theory  

Microsoft Academic Search

\\u000a The aim of this article is to present an elementary introduction to classical knot theory. The word classical means two things.\\u000a First, it means the study of knots in the usual 3D space R\\u000a 3 or S\\u000a 3. It also designates knot theory before 1984. In section 1 we describe the basic facts: curves in 3D space, isotopies, knots,\\u000a links

Claude Weber

416

Electrostatics interactions in classical simulations.  

PubMed

Electrostatic interactions are crucial for both the accuracy and performance of atomistic biomolecular simulations. In this chapter we review well-established methods and current developments aiming at efficiency and accuracy. Specifically, we review the classical Ewald summations, particle-particle particle-method particle-method Ewald algorithms, multigrid, fast multipole, and local methods. We also highlight some recent developments targeting more accurate, yet classical, representation of the molecular charge distribution. PMID:23034752

Cisneros, G Andrés; Babin, Volodymyr; Sagui, Celeste

2013-01-01

417

Quantization of classical lagrangian mechanics  

NASA Astrophysics Data System (ADS)

The equations of motion of a massive rigid body in the Lagrange—Poisson case (when one point of the body is fixed) are expressed in Hamiltonian form, making it possible to describe the Lagrangian rigid body in terms of classical mechanics. Using Berezin's quantization algorithm, it is possible to associate the Lagrangian classical mechanics with a quantum system, namely, a system of two-level particles interacting with a resonant field.

Bogdanov, E. I.

1992-06-01

418

Early therapy monitoring with FDG-PET in aggressive non-Hodgkin's lymphoma and Hodgkin's lymphoma.  

PubMed

This study was designed to determine the value of 2-[fluorine-18]-fluoro-2-deoxy- d-glucose positron emission tomography (FDG-PET) in the early assessment of therapy response in lymphoma patients. We studied 20 patients with pathologically proven lymphoma, including 17 patients with aggressive non-Hodgkin's lymphoma and three patients with Hodgkin's lymphoma. All patients underwent whole-body FDG-PET imaging at baseline and after 1-2 cycles of chemotherapy. PET images were analysed visually and quantitatively by calculating the standardised uptake value (SUV). In each patient, we measured the SUV of the tumour demonstrating the highest FDG uptake at baseline study and the SUV of the same tumour after 1-2 cycles of therapy. The achievement of complete response was assessed on the basis of a combination of clinical findings and the results of conventional imaging modalities. Follow-up of progression-free survival (PFS) was obtained for the validation of PET data. Of the 20 patients, ten achieved complete remission at the completion of chemotherapy and the other ten did not respond to chemotherapy. Of the ten responders, four are still in remission (PFS 24-34 months) while the other six have relapsed (PFS 8-16 months). For the prediction of 24-month clinical outcome, visual analysis of PET after 1-2 cycles showed high sensitivity (87.5%) and accuracy (80%) but low specificity (50%). Comparison with the baseline SUVs revealed that the responders showed a significantly greater percent reduction in SUV after 1-2 cycles of therapy as compared with the non-responders (81.2%+/-9.5% vs 35.0%+/-20.2%, P<0.001). In addition, using 60% reduction as a cut-off value, the responders were clearly separated from the non-responders, with the exception of one non-responder. In conclusion, when performed early during chemotherapy, FDG-PET may be predictive of clinical outcome and allows differentiation of responders from non-responders in cases of aggressive lymphoma. PMID:14574514

Torizuka, Tatsuo; Nakamura, Fumitoshi; Kanno, Toshihiko; Futatsubashi, Masami; Yoshikawa, Etsuji; Okada, Hiroyuki; Kobayashi, Masahide; Ouchi, Yasuomi

2003-10-22

419

Increased risk of lung cancer, non-Hodgkin's lymphoma, and leukemia following Hodgkin's disease  

SciTech Connect

The risk of second cancers (SCs) was assessed in 744 patients with Hodgkin's disease (HD) admitted to The Netherlands Cancer Institute from 1966 to 1983. Sixty-nine SCs were observed one month or more after start of first treatment. These included 14 cases of lung cancer, nine cases of non-Hodgkin's lymphoma (NHL), 16 cases of leukemia, and six cases of the myelodysplastic syndrome (MDS). The median interval between the diagnosis of HD and that of second lung cancer, NHL, and leukemia was 8.1, 13.3, and 5.7 years, respectively. The overall relative risks (RR) (observed/expected (O/E) ratios) of developing lung cancer, NHL, and leukemia were 4.9 (95% confidence limit (CL), 2.7 to 8.2), 31.0 (95% CL, 14.2 to 58.9) and 45.7 (95% CL, 26.1 to 74.2), respectively. At 15 years the cumulative risk of developing an SC amounted to 20.6% +/- 2.9%. The 15-year estimates of lung cancer, NHL, and leukemia were 6.2% +/- 1.9%, 5.9% +/- 2.1% and 6.3% +/- 1.7%, respectively. Increased lung cancer risk following HD has not frequently been clearly demonstrated before; that we were able to demonstrate such risk may be due to the completeness of follow-up over long periods that could be achieved in this study. Excess lung cancer risk was only noted in treatment regimens with radiotherapy (RT); also, all lung cancers arose in irradiation fields. Excess risk of leukemia was only found in treatment regimens involving chemotherapy (CT). For NHL, combined modality treatment was shown to be the most important risk factor. Risk of lung cancer and NHL increased with time since diagnosis. A time-dependent covariate analysis (Cox model) performed on leukemia and MDS showed an increasing risk with intensity of CT, age (greater than 40 years), and a splenectomy.

van Leeuwen, F.E.; Somers, R.; Taal, B.G.; van Heerde, P.; Coster, B.; Dozeman, T.; Huisman, S.J.; Hart, A.A. (Netherlands Cancer Institute, Amsterdam)

1989-08-01

420

Recent Advances in the Pathobiology of Hodgkin's Lymphoma: Potential Impact on Diagnostic, Predictive, and Therapeutic Strategies  

PubMed Central

From its first description by Thomas Hodgkin in 1832, Hodgkin's disease, now called Hodgkin's lymphoma, has continued to be a fascinating neoplasm even to this day. In this review, historical aspects, epidemiology, diagnosis, tumor biology, new observations related to host-microenvironment interactions, gene copy number variation, and gene expression profiling in this complex neoplasm are described, with an exploration of chemoresistance mechanisms and potential novel therapies for refractory disease.

Banerjee, Diponkar

2011-01-01

421

Blood Transfusion and Risk of Non-Hodgkin's Lymphoma in Connecticut Women  

Microsoft Academic Search

The incidence and mortality rates of non-Hodgkin's lymphoma have been increasing worldwide. Allogeneic blood transfusion has been suggested as a risk factor for non-Hodgkin's lymphoma, but the results from epidemiologic studies have been inconsistent. Data from a population-based case-control study of Connecticut women were analyzed to evaluate this relation. A total of 601 histologically confirmed, non-Hodgkin's lymphoma incident cases identified

Yawei Zhang; Theodore R. Holford; Brian Leaderer; Peter Boyle; Shelia Hoar Zahm; Patricia H. Owens; Lindsay M. Morton; Bing Zhang; Kaiyong Zou; Stuart Flynn

422

Vitamin Supplement Use and Fatal Non-Hodgkin's Lymphoma among US Men and Women  

Microsoft Academic Search

The authors evaluated the association between use of individual supplements of vitamins A, C, and E only and multivitamins and fatal non-Hodgkin's lymphoma in a large prospective mortality study of US men and women. During 14 years of follow-up (1982-1996), 1,571 non-Hodgkin's lymphoma deaths among 508,351 men and 1,398 non-Hodgkin's lymphoma deaths among 676,306 women were documented. Long-term regular use

Shumin M. Zhang; Eugenia E. Calle; Jennifer M. Petrelli; Eric J. Jacobs; Michael J. Thun

423

Supporting Chinese Speaking Skills Online  

ERIC Educational Resources Information Center

|Chinese is considered a difficult language to learn by most Western learners, yet recently more and more people are learning Chinese, and increasingly teaching is delivered online. Due to the nature of Chinese and the complexity of online learning, research has not yet produced sufficient information on students' and teachers' interaction during…

Stickler, Ursula; Shi, Lijing

2013-01-01

424

Concepts of Chinese Folk Happiness  

ERIC Educational Resources Information Center

|Discourses on Chinese folk happiness are often based on anecdotal narratives or qualitative analysis. Two traditional concepts of happiness popular in Chinese culture are introduced. The paper constructs a concept of Chinese folk happiness on basis of the findings of a scientific survey on the Taiwanese people regarding their concepts of…

Ip, Po Keung

2011-01-01

425

Concepts of Chinese Folk Happiness  

ERIC Educational Resources Information Center

Discourses on Chinese folk happiness are often based on anecdotal narratives or qualitative analysis. Two traditional concepts of happiness popular in Chinese culture are introduced. The paper constructs a concept of Chinese folk happiness on basis of the findings of a scientific survey on the Taiwanese people regarding their concepts of…

Ip, Po Keung

2011-01-01

426

Chinese Feminisms Encounter International Feminisms  

Microsoft Academic Search

This article focuses on three key debates within China about the formation of Chinese feminisms: the origin of the Chinese women's movement; the theoretical debates on the origin of women's subordination; and what constitutes legitimate knowledge. It considers these internal debates in relation to the dialogues that Chinese feminists have pursued with western feminisms, and more specifically UN-based international feminisms.

Feng Xu

2009-01-01

427

Guanxi in the Chinese Web  

Microsoft Academic Search

Guanxi is a type of dyadic social interaction based on feelings, trust, and the development of friendship. In this paper, we define the concept of guanxi as it is applied to the interaction between web sites. We show by analyzing the local linking structure between Chinese web sites and the content of Chinese web documents that interaction between Chinese web

Valerie King; Louis Yu; Yan Zhuang

2009-01-01

428

Overseas Chinese in Southeast Asia  

Microsoft Academic Search

Approximately 10 million overseas Chinese reside in Southeast Asia where they have economic power and political significance out of all proportion to their numbers. Southeast Asian governments are determined to loosen the Chinese grip on their national economies, to achieve an unequivocal clarinca tion of the citizenship status of resident Chinese, to end foreign political activity among and to proceed

G. William Skinner

1959-01-01

429

The Chinese in Children's Books.  

ERIC Educational Resources Information Center

|This is a selective annotated list of children's books about China and the Chinese. Topics range from dynasties, the era of Western influence, emigration, revolution, to present day affairs. Most of the books have a Chinese setting, but some are about the Chinese in America. Listings are made under categories such as picture books, stories for…

New York Public Library, NY.

430

Chinese American Experience: San Francisco.  

ERIC Educational Resources Information Center

|This unit encourages students to explore the history and current situation of Chinese Americans. Organized around five lesson plans, the unit's first lesson begins with the students' own perceptions of Chinese Americans, followed by a quiz that provides relevant background information. The second lesson examines the general history of Chinese

Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

431

Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage

2013-10-08

432

Hodgkin's disease: origin of an eponym--and one that got away.  

PubMed Central

Hodgkin's disease, the syndrome of enlarged lymph nodes associated with enlarged spleen, was described in 1832 on the basis of the gross appearance of the affected parts. The eponym entered the medical literature after repeated attempts by Dr. Samuel Wilks to credit Thomas Hodgkin with the priority of discovery. Today, this malady, also known by many other names, is recognized by microscopic examination of histological features. Hodgkin also described retroversion of the aortic valves with insufficiency in 1827 but Dr. Dominic Corrigan, whose report appeared in 1832, was credited with the eponym, despite efforts again by Wilks on behalf of Hodgkin. Images p622-a

Rosenfeld, L.

1989-01-01

433

Bibliographies for Chinese Studies  

NSDL National Science Digital Library

Professor Dr. Barend ter Haar, an instructor in the social and economic history of China at the Sinologisches Seminar (Sinological Institute) at Heidelberg University, offers this collection of regularly updated (with one exception) bibliographies on various aspects of Chinese culture and history. Topics include violence in Chinese culture, literacy, writing and education, the study of Yao religion, Shamanism in China, and religious culture in China. Each bibliography varies in length, but most are prefaced by some helpful remarks on the field and/or the secondary literature. Suggestions are welcome.

434

Ancient Chinese constellations  

NASA Astrophysics Data System (ADS)

China, a country with a long history and a specific culture, has also a long and specific astronomy. Ancient Chinese astronomers observed the stars, named and distributed them into constellations in a very specific way, which is quite different from the current one. Around the Zodiac, stars are divided into four big regions corresponding with the four orientations, and each is related to a totem, either the Azure Dragon, the Vermilion Bird, the White Tiger or the Murky Warrior. We present a general pattern of the ancient Chinese constellations, including the four totems, their stars and their names.

Xu, Junjun

2011-06-01

435

Chinese Foreign Policy Net  

NSDL National Science Digital Library

Developed by M. Taylor Fravel of Stanford University, Chinese Foreign Policy Net is a compendium of online information resources related to the study of Chinese foreign relations. The site organizes resources into sections that cover major issues: Security, Trade, Human Rights, and Bilateral Relations. Information resources include news services, academic reports, think tank policy papers, government documents, scholarly journals, economic data sets, and much more. The site also links to numerous academic and military research centers monitoring the foreign policy of People's Republic of China.

436

Distribution of Chinese names  

NASA Astrophysics Data System (ADS)

We present a statistical model for the distribution of Chinese names. Both family names and given names are studied on the same basis. With naive expectation, the distribution of family names can be very different from that of given names. One is affected mostly by genealogy, while the other can be dominated by cultural effects. However, we find that both distributions can be well described by the same model. Various scaling behaviors can be understood as a result of stochastic processes. The exponents of different power-law distributions are controlled by a single parameter. We also comment on the significance of full-name repetition in Chinese population.

Huang, Ding-wei

2013-03-01

437

The impact of treatment, socio-demographic and clinical characteristics on health-related quality of life among Hodgkin’s and non-Hodgkin’s lymphoma survivors: a systematic review  

Microsoft Academic Search

Cancer survivors are at risk of experiencing adverse physical and psychosocial effects of their cancer and its treatment.\\u000a Both Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL) survivors face problems that can affect their health-related\\u000a quality of life (HRQoL). The authors systematically reviewed the literature on HRQoL among HL and NHL survivors. A PubMed\\u000a and PsychINFO literature search for original articles

Simone Oerlemans; Floortje Mols; Marten R. Nijziel; Marnix Lybeert; Lonneke V. van de Poll-Franse

2011-01-01

438

The Classification and Application of Toxic Chinese Materia Medica.  

PubMed

Many important drugs in the Chinese materia medica (CMM) are known to be toxic, and it has long been recognized in classical Chinese medical theory that toxicity can arise directly from the components of a single CMM or may be induced by an interaction between combined CMM. Traditional Chinese Medicine presents a unique set of pharmaceutical theories that include particular methods for processing, combining and decocting, and these techniques contribute to reducing toxicity as well as enhancing efficacy. The current classification of toxic CMM drugs, traditional methods for processing toxic CMM and the prohibited use of certain combinations, is based on traditional experience and ancient texts and monographs, but accumulating evidence increasingly supports their use to eliminate or reduce toxicity. Modern methods are now being used to evaluate the safety of CMM; however, a new system for describing the toxicity of Chinese herbal medicines may need to be established to take into account those herbs whose toxicity is delayed or otherwise hidden, and which have not been incorporated into the traditional classification. This review explains the existing classification and justifies it where appropriate, using experimental results often originally published in Chinese and previously not available outside China. Copyright © 2013 John Wiley & Sons, Ltd. PMID:23722570

Liu, Xinmin; Wang, Qiong; Song, Guangqing; Zhang, Guangping; Ye, Zuguang; Williamson, Elizabeth M

2013-05-31

439

Hodgkin's Lymphoma in Children and Adolescents: A Saint Petersburg Hodgkin's Lymphoma Group Study  

PubMed Central

Purpose. Prospective analysis of the efficacy of the original protocol SPbHL-05 was performed. Patients and Methods. Sixty patients with Hodgkin's lymphoma (HL) aged less than 18 years old were treated in accordance with SPbHL-05 from January 2000, to July 2009. In induction chemotherapy we used VBVP and ABVD schedules followed by involved-field radiotherapy. Fourteen patients (23,3%) with 0–2 adverse factors (the favourable group) received two cycles of chemotherapy (VBVP), 25 children (41,7%) with 3-4 unfavorable signs (the intermediate group) received two cycles of VBVP alternating with two cycles of ABVD, 21 patient (35%) who had 5 or more adverse prognostic factors (the unfavourable group) received three cycles of VBVP alternating with three cycles of ABVD. Results. With a median follow-up of 68 months, overall survival (OS) at 5 years is 91.3%, event-free survival (EFS) is 82.8%. OS in the favourable and intermediate risk group were 100%, EFS were 92,9% and 90,7%, respectively, OS and EFS in unfavourable risk group—77,1% and 55,6%, respectively. Conclusion. The identification of prognostic risk factors and using medicines with less prominent side effects would be of major importance in the development of new strategies of treatment for childhood HL.

Kulyova, Svetlana A.; Kolygin, Boris A.

2011-01-01

440

Unusual thoracic radiographic findings in children treated for Hodgkin's disease  

SciTech Connect

Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

1986-06-01

441

[Hodgkin's disease associated with Tolosa-Hunt syndrome].  

PubMed

A thirty-eight-year-old man developed gradually progressing right retro-orbital pain, diplopia on the left lateral gaze, and left ptosis. On examination paresthesia was present on the first division of right trigeminal nerve. Orbital venography revealed obstruction of right superior orbital vein on the entering portion to the cavernous sinus. A daily administration of 30 mg of prednisolone resulted in a rapid improvement of the symptoms. Diagnosis of Tolosa-Hunt syndrome was made on the basis of neurological symptoms, roentgenographic findings and responsiveness to prednisolone. One year later, weakness of right leg accompanied with left cervical and axillary lymphadenopathy was developed. A biopsy specimen of cervical lymph node was identical with the Hodgkin's disease, lymphocyte predominance type. He was treated with COPP regimen; lymphadenopathy decreased in size. We reported a rare case of Hodgkin's disease preceded by Tolosa-hunt syndrome which might be caused by the extranodal lesions. PMID:2329680

Sakamoto, N; Aoyagi, Y; Ozaki, Y; Kanayama, M; Kimula, Y; Akabane, H

1990-02-01

442

Thyroid neoplasia following radiation therapy for Hodgkin's lymphoma  

SciTech Connect

The question of thyroid neoplasia following high-dose radiation treatment to the neck and mediastinum for malignant neoplasms such as Hodgkin's lymphoma in children and young adults has been raised recently. Five patients, 19 to 39 years old, were operated on for thyroid neoplasms that developed following cervical and mediastinal radiation therapy for Hodgkin's lymphoma. Three patients had papillary carcinomas and two had follicular adenomas. The latency period between radiation exposure and the diagnosis of thyroid neoplasm ranged from eight to 16 years. This limited series provided strong support for the recommendation that children and young adults who are to receive high-dose radiation therapy to the head, neck, and mediastinum should receive suppressive doses of thyroxine prior to radiation therapy in order to suppress thyrotropin (thyroid-stimulating hormone) and then be maintained on a regimen of suppression permanently.

McHenry, C.; Jarosz, H.; Calandra, D.; McCall, A.; Lawrence, A.M.; Paloyan, E.

1987-06-01

443

Late complications of therapy of Hodgkin's disease: prevention and management.  

PubMed

Patients diagnosed with Hodgkin's disease have a high cure rate. However, long-term survivors of the disease are at significantly increased risk for many late complications. The most serious late effects faced by these patients include the development of a second malignancy or cardiovascular disease. Ongoing trials investigating treatment reduction, including using lower radiation dose, smaller radiation field size, and abbreviated chemotherapy, will hopefully help in limiting the treatment-related complications. Continued long-term follow-up of survivors, careful documentation of the broad range of late effects, identification of risk factors, development and evaluation of screening programs, and preventative therapy for specific late complications are important steps in improving the survival and quality of life of patients who have been cured of Hodgkin's disease. PMID:14695846

Ng, Andrea K; Mauch, Peter M

2004-01-01

444

Isolated, primary spinal epidural Hodgkin's disease in a child.  

PubMed

A 12-year-old boy presented with backache and bilateral progressive lower extremity weakness. Radiological examination revealed a mass on the epidural space at level L(1)-L(3). The patient had laminectomy and posterior decompression. Histopathology examination revealed lymphocyte dominant type Hodgkin's disease. All other investigations (including computed tomography of the chest and abdomen, bone scan, gallium scan, bone marrow aspiration, and cerebrospinal fluid study) were negative for occult disease. The patient received combined therapy with irradiation and chemotherapy after surgery. At 7 years after the diagnosis, he had remained disease free and with normal functional status. This patient represents a rare case of primary epidural Hodgkin's disease in the lumbar region, rare also for onset in childhood. PMID:19433288

Samadian, Mohammad; Vahidi, Shifteh; Khormaee, Fatemeh; Ashraf, Haleh

2009-06-01

445

Complications of treatment of Hodgkin's disease in children  

SciTech Connect

An analysis of complications of therapy requires long-term and frequent followup. Reported here is a review of 179 consecutive children with Hodgkin's disease from Stanford University Medical Center who were seen, treated, and followed over a 20-year period. Complications of treatment are related to the extent of disease and the aggressiveness of therapy. Severe complications from radiotherapy are associated with high-dose, extended-field treatment in preadolescent children. Severe chemotherapy-associated complications include immunosuppression, sterility, and secondary oncogenesis. As cure rates are increasingly optimistic among children with Hodgkin's disease, successful treatment with minimal morbidity remains our greatest challenge. Therapy programs require continual refinement utilizing assessment of short- and long-term side effects of treatment.

Donaldson, S.S.; Kaplan, H.S.

1982-04-01

446

Multimodality therapy of favorable prognosis non-Hodgkin's lymphoma  

SciTech Connect

Twenty-seven previously untreated patients with favorable prognosis non-Hodgkin's lymphoma were treated with a combination of total body irradiation followed by cyclophosphamide - vincristine - prednisone (CVP). The dose of total body irradiation was planned to be 150 rad followed by 6 cycles of chemotherapy. The complete response rate was 59%; the complete plus partial response rate, 93%. The 50% disease-free survival was 8 months. The actuarial projected 5 year survival was 60% and the disease-free survival at 5 years was 27%. The program was well tolerated by the majority of patients. It is possible for some patients with favorable non-Hodgkin's lymphomas to achieve prolonged periods of disesase-free survival when treated with combinations of irradiation plus chemotherapy.

Corder, M.P. (Univ. of Iowa Hospitals, Iowa City); Leimert, J.T.; Tewfik, H.H.; Lovett, J.M.

1983-07-01

447

Concurrent Presentation of Hodgkin Lymphoma and Multiple Myeloma  

PubMed Central

The simultaneous presentation of the Hodgkin lymphoma and multiple myeloma in the absence of prior chemotherapy or radiation is very rare. Here, we discuss a 72-year-old patient who initially presented with generalized pruritis. Workup led to a diagnosis of multiple myeloma which progressed and required treatment. As part of his pretreatment workup, an MRI was performed to evaluate skeletal lesions. This revealed diffuse and bulky adenopathy which was confirmed by PET. A biopsy of an axillary node was consistent with the nodular sclerosing type Hodgkin lymphoma. He was treated with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) chemotherapy × 6 resulting in complete resolution of his adenopathy and pruritis as well as improvement in his myeloma.

Simon, Miklos; Spurgeon, Stephen E.

2013-01-01

448

Medication Use and Risk of Non-Hodgkin's Lymphoma  

Microsoft Academic Search

Conflicting results from previous epidemiologic studies shed little light on whether medication use is associated with risk of non-Hodgkin's lymphoma (NHL). To investigate this question, the authors conducted a population- based case-control study in Denmark and Sweden from 1999 to 2002, including 3,055 incident NHL cases and 3,187 controls. Participants reported their past use of medications and history of particular

Ellen T. Chang; Karin Ekstrom Smedby; Henrik Hjalgrim; Claudia Schollkopf; Anna Porwit-MacDonald; Christer Sundstrom; Edneia Tani; Francesco d'Amore; Mads Melbye; Hans-Olov Adami; Bengt Glimelius

2005-01-01

449

Does radiotherapy still have a place in Hodgkin lymphoma?  

Microsoft Academic Search

Over half a century, radiation therapy (RT) for Hodgkin lymphoma has been transformed from a radical, extensive, high-dose\\u000a therapy (which alone cured most patients) into an essential component of a comprehensive combined-modality program. RT is\\u000a now used in a “mini” version that encompasses only the clinically involved sites following chemotherapy and is administered\\u000a in a markedly reduced dose. This change

Joachim Yahalom

2009-01-01

450

Treatment of Hodgkin lymphoma: the past, present, and future  

Microsoft Academic Search

Significant advances in the biology and treatment of Hodgkin lymphoma (HL) have been accomplished over the past decades. In a landmark study, DeVita and colleagues showed that half of patients with advanced-stage HL experienced long-term disease-free survival following treatment with a four-drug chemotherapy regimen. Subsequent reports and randomized clinical trials conducted over the past 40 years have defined prognostic categories

Martin Hutchings; Volker Diehl; Andrew M Evens

2008-01-01

451

DNA content and prognosis of non-Hodgkin's lymphoma  

Microsoft Academic Search

Ninety cases of non-Hodgkin's lymphoma diagnosed prior to the use of modern therapeutic regimens (1963-67) and 88 cases treated with such chemotherapy (1980-85) were studied using conventional morphology and flow cytometry. DNA aneuploidy as determined by flow cytometry was more common among high grade (38%) than low grade (19%) tumours (P less than 0.01). Measurements of proliferative index (S +

D R Morgan; J M Williamson; P Quirke; A D Clayden; M E Smith; C J O'Brien; D L Allison; J A Child; C C Bird

1986-01-01

452

CNS manifestations in non-Hodgkin lymphomas (NHL)  

Microsoft Academic Search

Summary In a group of 241 patients with non-Hodgkin lymphoma investigated retrospectively, CNS manifestations occurred in 8%, mainly as meningeosis lymphoblastomatosa. Lymphoblastic and immunoblastic NHL showed the highest risk of CNS infiltration (40.7% and 12.5% respectively). Further risk factors were disseminated stage of the disease, prior involvement of the bone marrow and juvenile age. Characteristic symptoms were eye muscle paresis,

M. Freund; P. Ostendorf; V. H. Gärtner; H. D. Waller

1983-01-01

453

A sinister itch: prurigo nodularis in Hodgkin lymphoma.  

PubMed

A 24 year old lady presented with pruritis and lichenified nodular skin lesions for 1 year. She also had clinical features to suggest a superior venacaval syndrome (SVC) with large rubbery cervical lymph nodes. She was subsequently diagnosed to have Hodgkin lymphoma on lymph node biopsy. Skin changes in lymphoma can precede other clinical symptoms by months. High clinical suspicion and thorough systemic examination would help in excluding a sinister problem in patients with chronic dermatosis. PMID:20329432

Seshadri, Pratibha; Rajan, Sudha Jasmine; George, Ige Abraham; George, Renu

2009-10-01

454

Stem Cell Transplantation in Childhood Non-Hodgkin’s Lymphomas  

Microsoft Academic Search

Despite the high cure rates achieved with intensified primary therapies for childhood non-Hodgkin’s lymphomas (NHL), the prognosis\\u000a for children with relapsed or refractory disease is poor. Optimal treatment for this group remains a challenge. Dose intensification\\u000a followed by stem cell transplantation has been used in these circumstances and may provide a curative treatment option for\\u000a these patients, but the number

Fatma V. Okur; Robert Krance

2010-01-01

455

Tracheomediastinal Fistula Caused by Non-Hodgkin's Lymphoma.  

PubMed

Non-Hodgkin's lymphoma involving the tracheobronchial tree is uncommon. A 60-year-old man presented with severe cough for two months. Bronchoscopy disclosed an ulcerative lesion at the lower trachea and carina with anterior tracheomediastinal fistula, and biopsy revealed tracheal wall B-cell lymphoma. After chemo-radiotherapy, the tracheomediastinal fistula healed, but eight months later, tracheal stenosis was diagnosed by bronchoscopy. A self-expansible metallic stent was placed, which successfully maintained the airway. PMID:23603637

Huang, Chang-Lun; Chen, Heng-Chung; Huang, Hung-Che; Cheng, Ching-Yuan

2013-04-20

456

Canards for a reduction of the Hodgkin-Huxley equations  

Microsoft Academic Search

This paper shows that canards, which are periodic orbits for which the trajectory follows both the attracting and repelling\\u000a part of a slow manifold, can exist for a two-dimensional reduction of the Hodgkin-Huxley equations. Such canards are associated\\u000a with a dramatic change in the properties of the periodic orbit within a very narrow interval of a control parameter. By smoothly

Jeff Moehlis

2006-01-01

457

Pleural mesothelioma associated with non-Hodgkin's lymphoma.  

PubMed Central

Occupational exposure to asbestos has been associated with an increased incidence of lung and gastric cancers, mesotheliomas, and myelolymphoid malignancies. A new observation of a patient with indirect exposure to asbestos who developed mesothelioma and plasmacytoid lymphocytic non-Hodgkin's lymphoma is described. This report and the previously described stimulation of B lymphocytes by asbestos suggests that the association of mesothelioma with lymphoid and plasma cell malignancies is not merely a coincidence. Images

Tondini, M; Rocco, G; Travaglini, M; Rossi, G; Buscemi, A; de Fazio, L

1994-01-01

458

Non-Hodgkin's lymphomas, version 1.2013.  

PubMed

These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Non-Hodgkin's Lymphomas (NHL) and provide a discussion of the clinical evidence that support the updates. The updates discussed in this article feature recommendations for additional treatment options in patients with chronic lymphocytic leukemia and guidance surrounding the management of hepatitis virus reactivation/infections in high-risk patients with NHL undergoing antitumor therapy. PMID:23486452

Zelenetz, Andrew D; Wierda, William G; Abramson, Jeremy S; Advani, Ranjana H; Andreadis, C Babis; Bartlett, Nancy; Bellam, Naresh; Byrd, John C; Czuczman, Myron S; Fayad, Luis E; Glenn, Martha J; Gockerman, Jon P; Gordon, Leo I; Harris, Nancy Lee; Hoppe, Richard T; Horwitz, Steven M; Kelsey, Christopher R; Kim, Youn H; Krivacic, Susan; LaCasce, Ann S; Nademanee, Auayporn; Porcu, Pierluigi; Press, Oliver; Pro, Barbara; Reddy, Nishitha; Sokol, Lubomir; Swinnen, Lode; Tsien, Christina; Vose, Julie M; Yahalom, Joachim; Zafar, Nadeem; Dwyer, Mary A; Naganuma, Maoko

2013-03-01

459

Central Nervous System Involvement in Non-Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Primary central nervous system (CNS) non-Hodgkin lymphoma (NHL) comprises 1 to 3% of primary brain tumors, 6% of all intracranial\\u000a neoplasms and about 1% of all lymphomas (Coulon et al. 2002). Onset is most common in the sixth and seventh decades. It usually presents as a brain tumor, but may also involve the leptomeninges,\\u000a eyes, and spinal cord. Its incidence

François Lafitte; Carmen Adem; AgnèS Coulon; Jacques Chiras

460

Hodgkin Lymphoma in Special Populations and Rare Localizations  

Microsoft Academic Search

\\u000a Hodgkin lymphoma (HL) is seen in patients over the age of 60 in 20–40% of cases. Prognosis is poorer, largely due to suboptimal\\u000a staging and treatment in some patients due to concurrent disease. If possible, older patients should be treated along the\\u000a same principles as younger patients. HL in the pregnant patient should be treated on an individual basis; in

Peter Meidahl Petersen

461

Palinopsia as the initial manifestation of non-hodgkin's lymphoma.  

PubMed

A 37-year old general practitioner thought to be in good health presented to the ophthalmology department with palinopsia, headaches and transient visual obscurations. A CT scan revealed a large destructive lesion centred on the occiput and stealth guided excisional biopsy of the occipital lesion showed diffuse large B cell, Non-Hodgkin's lymphoma (NHL) infiltration. To the best of our knowledge this is only the second report of a patient with NHL presenting with palinopsia. PMID:23188189

Ziaei, Mohammed; Elgohary, Mostafa A; Bremner, Fion D

2012-11-29

462

Disordered development of macrophages in non-Hodgkin’s lymphoma  

Microsoft Academic Search

Summary  Macrophage development in 20 untreated patients with non-Hodgkin’s lymphoma (NHL) has been studied and compared with that\\u000a in 20 normal subjects. Morphometric measurements were carried out on ultrastructural features of cell, nucleus and mitochondria\\u000a during 6 days suspension culture of blood monocytes in the presence of autologous serum and lymphocytes. The results were\\u000a subjected to multivariate and univariate analysis of

R. J. Sokol; G. Hudson; N. T. James; J. Wales

1988-01-01

463

Characterization of B-cell non-Hodgkin's lymphomas  

Microsoft Academic Search

A panel of monoclonal and heterologous antibodies directed against clearly defined antigens was used to characterize the cellular composition of 57 non-Hodgkin's lymphomas, classified according to the Kiel classification, with a slight modification. The antisera were directed against T-lymphocytes and their subsets (Leu1, Leu2a, Leu3a, TA1), B-lymphocytes and their subsets (BA1, BA2, HLA-DR, CR1, sIg), macrophages (TA1, OKM1, anti-human monocyte

P. van der Valk; J. Jansen; M. R. Daha; C. J. L. M. Meijer

1983-01-01

464

Acute nonlymphocytic leukemia: onset after treatment for Hodgkin's disease  

Microsoft Academic Search

This study was undertaken to examine the influence of various factors on the occurrence of acute nonlymphocytic leukemia\\u000a (ANLL) in a group of long-term survivors of Hodgkin's disease (HD). From 1972 to 1992, 1045 patients with HD were assessed\\u000a and treated at the Department of Radiation Oncology, the Institute of Radiology, and the Department of Human Biopathology,\\u000a Hematology Section, University

R. Maurizi Enrici; A. P. Anselmo; M. F. Osti; M. Santoro; S. Sbarbati; V. Tombolini; F. Mandelli; E. D'Arcangelo; C. Biagini

1997-01-01

465

Fatigue and Psychiatric Morbidity Among Hodgkin's Disease Survivors  

Microsoft Academic Search

Fatigue is prevalent among cancer patients, including Hodgkin's disease survivors (HDS). Fatigue is poorly understood, and the clinical management is consequently difficult. This cross-sectional study examined how fatigue related to psychiatric morbidity among 457 HDS (aged 19–74 years, 56% males) treated during the period 1971–1991. The subjects were mailed a questionnaire including the Fatigue Questionnaire, the Hospital Anxiety and Depression

Jon Håvard Loge; Arne Foss Abrahamsen; Øivind Ekeberg; Stein Kaasa

2000-01-01

466

Pseudo-Lyapunov exponents and predictability of Hodgkin-Huxley neuronal network dynamics.  

PubMed

We present a numerical analysis of the dynamics of all-to-all coupled Hodgkin-Huxley (HH) neuronal networks with Poisson spike inputs. It is important to point out that, since the dynamical vector of the system contains discontinuous variables, we propose a so-called pseudo-Lyapunov exponent adapted from the classical definition using only continuous dynamical variables, and apply it in our numerical investigation. The numerical results of the largest Lyapunov exponent using this new definition are consistent with the dynamical regimes of the network. Three typical dynamical regimes-asynchronous, chaotic and synchronous, are found as the synaptic coupling strength increases from weak to strong. We use the pseudo-Lyapunov exponent and the power spectrum analysis of voltage traces to characterize the types of the network behavior. In the nonchaotic (asynchronous or synchronous) dynamical regimes, i.e., the weak or strong coupling limits, the pseudo-Lyapunov exponent is negative and there is a good numerical convergence of the solution in the trajectory-wise sense by using our numerical methods. Consequently, in these regimes the evolution of neuronal networks is reliable. For the chaotic dynamical regime with an intermediate strong coupling, the pseudo-Lyapunov exponent is positive, and there is no numerical convergence of the solution and only statistical quantifications of the numerical results are reliable. Finally, we present numerical evidence that the value of pseudo-Lyapunov exponent coincides with that of the standard Lyapunov exponent for systems we have been able to examine. PMID:20020192

Sun, Yi; Zhou, Douglas; Rangan, Aaditya V; Cai, David

2009-12-18

467

Gene expression profiling in anaplastic large cell lymphoma and Hodgkin's disease.  

PubMed

Recent efforts have been made to isolate molecular targets that could explain different outcome between histological subtypes of lymphomas and to understand the molecular mechanisms underlying oncogenic events. Using the SSH technique, we compared the transcriptome of 2 cases of ALK+ and ALK- anaplastic large cell lymphoma (ALCL) and of 2 cases of classical Hodgkin's lymphoma (cHL) with opposite behavior. Regarding ALCL, we showed that ALK-positive tumors overexpressed genes involved in different signaling pathways such as activation or signaling of T-cells, regulation of apoptosis, phospholipase Cgamma and phosphatidyl inositol-3 Kinase. In addition, the characterization of a specific molecular signature may be of clinical relevance since ALK+ tumors generally have a better prognosis than ALK- ones. Similar problems of differential prognosis is observed in cases of cHL, which in addition, may be morphologically and immunologically indistinguishable. Therefore, we applied the same SSH technique to 2 cHL samples from patients with favorable and poor outcome, respectively. Forty-four cDNAs were significantly overexpressed in the poor outcome case. In addition to the defender against death cell 1 (DAD1) gene, overexpressed clones corresponded mostly to expressed sequence tags (ESTs). Interestingly, the present study identifies new genes which may be involved in the pathogenesis and/or clinical outcome of cHL and deserve further investigations. PMID:15370244

Trempat, Pascal; Villalva, Claire; Xerri, Luc; Armstrong, Florence; Duplantier, Marie-Michele; Delsol, Georges; Brousset, Pierre

2004-10-01

468

[No Hodgkin Linfoma diagnosis with intra-atrial infiltration].  

PubMed

Cardiac tumors are rare entities in clinical practice, with an incidence of 0.05%. Approximately 75% are benign and 25% malignant. Among these, Lymphomas are uncommon, representing about 0.25%. The non-Hodgkin lymphomas can occur in extranodal tissues in 20% of the cases and 80% of these non-Hodgkin lymphomas are composed of diffuse B cells. The extranodal presentation is most frequent in young adults, with a high degree of malignancy and rapid growth. It can present with primary infiltration of various organs; cardiac involvement occurs in 20 to 28% of cases, usually located in the right chambers and with nonspecific symptoms, depending on the location and extent of the tumor. The diagnostic test in these cases is undoubtedly the biopsy of the lymph node or the affected tissue. We present the case of non-Hodgkin disease of diffuse large cells, with right intra-atrial involvement in a 23-year-old-female patient, who presented with progressive dyspnea. A transesophageal echocardiography was performed and an intra-atrial tumor mass was detected. A biopsy was performed, by femoral venous catheterization, allowing the establishment of the histopathological diagnosis and treatment. At a one year follow up, the patient shows complete remission. PMID:23248972

Alcocer Gamba, Marco Antonio; León González, Salvador; Castro Montes, Eliodoro; Loarca Piña, Luis Martín; Lugo Gavidia, Leslie Marisol; García Hernández, Enrique; González Galindo, Ulises; Paredes Serrano, Miguel Isaías

2012-09-01

469

Primary non-Hodgkin's lymphoma of the mediastinum  

SciTech Connect

Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6%) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extrathoracic disease at presentation. Eleven of the 12 patients presented with extensive contiguous extranodal disease (Stage II/sub E/) with involvement of either the pericardium, sternum, chest wall, pulmonary parenchyma or, in four cases, with superior venacaval obstruction. Diffuse large cell lymphoma (eight cases) and diffuse poorly differentiated lymphocytic lymphoma (four cases) were the prevalent histologic subtypes; no instances of lymphoblastic lymphoma without extra-thoracic spread were encountered. None of four lymphomas studied could be characterized as either B- or T-cell tumors utilizing conventional surface marker techniques. Ten of the 12 patients achieved complete remissions, either after treatment with combination chemotherapy alone (three patients) or after both chemotherapy and mediastinal irradiation (seven patients). Two of these ten have subsequently relapsed, but median survival has not been reached after a mean period of observation of 28 months. Primary nonlymphoblastic non-Hodgkin's lymphoma of the mediastinum is more common than previously realized, displays aggressive contiguous spread within the chest and responds well to combination chemotherapy with or without adjuvant mediastinal irradiation.

Levitt, L.J.; Aisenberg, A.C.; Harris, N.L.; Linggood, R.M.; Poppema, S.

1982-12-01

470

Functional hyposplenia after splenic irradiation for Hodgkins's disease  

SciTech Connect

We previously reported a patient who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n = 19) or non-Hodgkin's lymphoma (n = 6). Mean maximum splenic diameter as measured on a /sup 99//sup m/Tc-sulfur colloid liver-spleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p < 0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p < 0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

Coleman, C.N.; McDougall, I.R.; Dailey, M.O.; Ager, P.; Bush, S.; Kaplan, H.S.

1982-01-01

471

Functional hyposplenia after splenic irradiation for Hodgkin's disease  

SciTech Connect

We previously reported a patients who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n . 19) or non-Hodgkin's lymphoma (n . 6). Mean maximum splenic diameter as measured on a 99mTc-sulfur colloid liver-spleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p less than 0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p less than 0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

Coleman, C.N.; McDougall, I.R.; Dailey, M.O.; Ager, P.; Bush, S.; Kaplan, H.S.

1982-01-01

472