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1

Immunological Deregulation in Classic Hodgkin Lymphoma  

PubMed Central

Classic Hodgkin Lymphoma (cHL) has a unique histology since only a few neoplastic cells are surrounded by inflammatory accessory cells that in the last years have emerged as crucial players in sustaining the course of disease. In addition, recent studies suggest that the abnormal activity of these inflammatory cells (such as deregulation in regulatory T cells signaling, expansion of myeloid derived suppressor cells, HLA-G signaling and natural killer cells dysfunction) may have prognostic significance. This review is focused on summarizing recent advanced in immunological defects in cHL with translational implications. PMID:24959336

Romano, Alessandra; Vetro, Calogero; Caocci, Giovanni; Greco, Marianna; Parrinello, Nunziatina Laura; Di Raimondo, Francesco; La Nasa, Giorgio

2014-01-01

2

Blood . Author manuscript Occurrence of minimal change nephrotic syndrome in classical Hodgkin  

E-print Network

Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells association with classical Hodgkin lymphoma (cHL-MCNS) suggests a molecular link between these two diseases-blotting. We found that c-mip was selectively expressed in Hodgkin and Reed-Sternberg (HRS) cells and podocytes

Paris-Sud XI, Université de

3

How I treat advanced classical Hodgkin lymphoma.  

PubMed

The development of curative systemic treatment of Hodgkin lymphoma was recently voted one of the top 5 achievements of oncology in the last 50 years (http://cancerprogress.net/top-5-advances-modern-oncology). The high expectation of cure (above 80%) with initial therapy, even for advanced disease, is tempered by the recognition of some important limitations: not all patients are cured, especially those in older age groups, and patients have suffered debilitating or, in some cases, fatal long-term side effects. The challenge for modern treatment approaches is to improve the cure rate and, at the same time, minimize the long-term damage resulting from treatment. After several decades during which we have tested a variety of different ways to combine conventional cytotoxic treatments with or without radiotherapy but have identified no effective new approaches, the field is once again moving forward. The developments that hold the greatest promise in this respect are the application of functional imaging with (18)F-fluorodeoxyglucose positron emission tomography (FDG-PET) to make an early judgment of the success of treatment and the introduction of some highly active new agents such as antibody-drug conjugates. PMID:25564404

Johnson, Peter; McKenzie, Hayley

2015-03-12

4

Classical Hodgkin's disease. Clinical impact of the immunophenotype.  

PubMed Central

Antibodies against CD15, -30, and -20 are often used to support morphological diagnosis of Hodgkin's Disease (HD). The classical HD, i.e., the non-lymphocyte-predominance types, are CD15+, CD30+, and CD20- in general. However, the results for CD15 are less clear-cut in many studies, showing up to 40% of classical HD that lack positivity for this maker. Little is currently known about the relevance of antigen expression in relation to clinical outcome in HD. Therefore, the three markers were analyzed in 1751 cases from the German Hodgkin Study Group, using micro-wave epitope retrieval to optimize staining sensitivity. Eighty-three percent of the cases showed a classical immunophenotype (CD15+, CD30+, CD20-), twelve percent lacked CD15 positivity (CD15-, CD30+, CD20-), and five percent showed other combinations. For 1286 cases, clinical follow-up was available, which revealed significant differences for freedom from treatment failure (P = 0.0022) and overall survival (P = 0.0001) between cases with classical immunophenotype and CD15 negativity (CD30+, CD20-). Multivariate Cox regression using the three markers, age, sex, histology, stage, B-symptoms (fever, sweats, weight loss > 10% of body weight), hemoglobin, and erythrocyte sedimentation rate as factors showed that lack of CD15 expression in classical HD is an independent negative prognostic factor for relapses (P = 0.022) and survival (P = 0.0035). In conclusion, immunohistochemistry is able to identify classical HD cases with unfavorable clinical outcome. Images Figure 5 Figure 6 PMID:9327746

von Wasielewski, R.; Mengel, M.; Fischer, R.; Hansmann, M. L.; Hübner, K.; Franklin, J.; Tesch, H.; Paulus, U.; Werner, M.; Diehl, V.; Georgii, A.

1997-01-01

5

Occurrence of minimal change nephrotic syndrome in classical Hodgkin's lymphoma is closely related to the induction of c-mip in Hodgkin-Reed  

E-print Network

1 Occurrence of minimal change nephrotic syndrome in classical Hodgkin's lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes Vincent Audard1,2, , Shao syndrome (I-MCNS) is an immune-mediated glomerular disease. Its association with classical Hodgkin lymphoma

Paris-Sud XI, Université de

6

An Approach to Teaching Classical Chinese Poetry.  

ERIC Educational Resources Information Center

English translations can be used to teach classical Chinese poetry to students above the intermediate level who have a limited vocabulary. To overcome this deficiency, and to bridge the gap between vernacular and literary Chinese, several texts are suggested. Examples are given to show the benefit of English translations. (PJM)

Hung, Ming-shui

1980-01-01

7

Risk and Outcome of Non-Hodgkin Lymphoma Among Classical Hodgkin Lymphoma Survivors  

PubMed Central

Background Classical Hodgkin lymphoma (cHL) survivors are at increased risk to develop secondary non-Hodgkin lymphomas (sNHL). The outcome of patients with sNHL relative to their de novo counterparts (dnNHL) is unknown. Methods We utilized data of 26,826 HL cases from the Surveillance Epidemiology and End Results (SEER) program diagnosed between 1992 and 2009 to obtain the risk of further development of different subtypes of sNHL. We then compared survival of sNHL with the survival of matched dnNHL patients. Results The estimated cumulative incidence of sNHL was 2.50% (95% C.I. 2.10-2.89) after 15 years from the diagnosis of cHL. The standardized incidence ratio (SIR) was 10.5 (95% C.I. 8.9-12.4) for aggressive B-cell NHL, 4.0 (95% C.I. 3.1-5.1) for indolent B-cell NHL and 14.6 (95% C.I. 10.3-20.1) for T cell NHL. Patients with indolent B-cell sNHL had worse OS than their dnNHL counterparts (HR of death 2.7, 95% CI 1.3-5.7). Survival was not significantly different between sNHL and dnNHL for aggressive B-cell NHL (HR 1.3, 95% C.I. 0.6-2.7) or T-cell NHL (HR 0.8, 95% C.I 0.3-1.8). Conclusions The risk of developing sNHL after cHL is substantial. While patients with indolent B-cell sNHL have inferior survival, patients with aggressive B-cell sNHL and T-cell sNHL have survival comparable to their de novo counterparts. PMID:23797978

Xavier, Ana C; Armeson, Kent E.; Hill, Elizabeth G; Costa, Luciano J

2013-01-01

8

Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma.  

PubMed

The hedgehog signaling pathway has been shown to play a pathogenic role in diffuse large B-cell lymphoma and anaplastic large cell lymphoma, but has not been assessed in classical Hodgkin lymphoma. Glioma-associated oncogene homologues 1, 2, and 3 are transcriptional effectors of the hedgehog pathway. In this study, we first used real-time quantitative polymerase chain reaction to investigate the expressions of GLI1, GLI2, and GLI3 in 3 classical Hodgkin lymphoma cell lines. GLI1 and GLI2 were variably expressed, but GLI3 was highly expressed in all cell lines. We then used immunohistochemistry to assess glioma-associated oncogene homologues 1, 2, and 3 in 39 classical Hodgkin lymphoma patient samples. Glioma-associated oncogene homologues 1 and 2 were weakly to variably expressed in a subset of classical Hodgkin lymphoma patient samples. In contrast, glioma-associated oncogene homologue 3 showed strong, uniform nuclear expression in virtually all Hodgkin/Reed-Stenberg cells. We then performed an immunohistochemical survey of glioma-associated oncogene homologue 3 expression in 13 cases of nodular lymphocyte predominant Hodgkin lymphoma and 218 non-Hodgkin lymphomas. Most other lymphoma types showed variable or no expression of glioma-associated oncogene homologue 3, with a minor subset of cases of nodular lymphocyte predominant Hodgkin lymphoma, ALK-positive and ALK-negative anaplastic large cell lymphoma, and B-cell lymphoma, unclassifiable with features intermediate between diffuse large B-cell lymphoma and classical Hodgkin lymphoma showing a glioma-associated oncogene homologue 3 staining pattern indistinguishable from classical Hodgkin lymphoma. Our data provide a rationale to further investigate the biologic significance of glioma-associated oncogene homologue 3 in classical Hodgkin lymphoma biology. PMID:21531006

Greaves, Wesley O; Kim, Ji Eun; Singh, Rajesh R; Drakos, Elias; Kunkalla, Kranthi; Sánchez-Espiridión, Beatriz; Garcia, Juan F; Medeiros, L Jeffrey; Vega, Francisco

2011-11-01

9

Decision-making in the management of adult classical Hodgkin's lymphoma: determining the optimal treatment.  

PubMed

This review discusses promising new approaches in classical Hodgkin's lymphoma that have been recently evaluated. There is a focus on the fluorodeoxyglucose PET scanning that is now considered crucial for staging and treatment evaluation, including interim evaluation after two cycles. An up-front treatment strategy is discussed, with the place of radiation therapy and the difficult choice of chemotherapy intensity emphasized. Indications for frail patients are also reviewed, particularly elderly or HIV-positive patients. Emerging data on the antibody drug conjugate brentuximab vedotin and its future potential in the transplantation framework for relapsed/refractory Hodgkin's lymphoma is also discussed. PMID:25634543

Nicolas, Mounier; Christian, Gisselbrecht

2015-04-01

10

BCL2 expression in Hodgkin and Reed-Sternberg cells of classical Hodgkin disease predicts a poorer prognosis in patients treated with ABVD or equivalent regimens  

Microsoft Academic Search

To determine the clinical significance of BCL-2 expression in Hodgkin-Reed-Stern- berg (HRS) cells of classical Hodgkin disease (cHD), we correlated its expres- sion with presenting clinical and labora- tory features and failure-free survival (FFS). Eligible patients were untreated and negative for HIV-1; they had biopsy- proven cHD. BCL-2 expression was deter- mined immunohistochemically in available pretreatment tissue biopsy specimens with-

George Z. Rassidakis; L. Jeffrey Medeiros; Theodoros P. Vassilakopoulos; Simonetta Viviani; Valeria Bonfante; Gianpaolo Nadali; Marco Herling; Maria K. Angelopoulou; Roberto Giardini; Marco Chilosi; Christos Kittas; Timothy J. McDonnell; Gianni Bonadonna; Alessandro M. Gianni; Giovanni Pizzolo; Gerassimos A. Pangalis; Fernando Cabanillas; Andreas H. Sarris

2002-01-01

11

Classical Hodgkin’s lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant  

PubMed Central

The Hodgkin’s Lymphoma Committee of the Lymphoma Study Association (LYSA) gathered in 2012 to prepare guidelines on the management of transplant-eligible patients with relapsing or refractory Hodgkin’s lymphoma. The working group is made up of a multidisciplinary panel of experts with a significant background in Hodgkin’s lymphoma. Each member of the panel of experts provided an interpretation of the evidence and a systematic approach to obtain consensus was used. Grades of recommendation were not required since levels of evidence are mainly based on phase II trials or standard practice. Data arising from randomized trials are emphasized. The final version was endorsed by the scientific council of the LYSA. The expert panel recommends a risk-adapted strategy (conventional treatment, or single/double transplantation and/or radiotherapy) based on three risk factors at progression (primary refractory disease, remission duration < 1 year, stage III/IV), and an early evaluation of salvage chemosensitivity, including 18fluorodeoxy glucose-positron emission tomography interpreted according to the Deauville scoring system. Most relapsed or refractory Hodgkin’s lymphoma patients chemosensitive to salvage should receive high-dose therapy and autologous stem-cell transplantation as standard. Efforts should be made to increase the proportion of chemosensitive patients by alternating non-cross-resistant chemotherapy lines or exploring the role of novel drugs. PMID:23904236

Van Den Neste, Eric; Casasnovas, Olivier; André, Marc; Touati, Mohamed; Senecal, Delphine; Edeline, Véronique; Stamatoullas, Aspasia; Fornecker, Luc; Deau, Bénédicte; Gastinne, Thomas; Reman, Oumédaly; Gaillard, Isabelle; Borel, Cécile; Brice, Pauline; Fermé, Christophe

2013-01-01

12

Infused autograft lymphocyte to monocyte ratio predicts survival in classical Hodgkin lymphoma  

PubMed Central

The infused autograft lymphocyte to monocyte ratio (A-LMR) as a surrogate marker of host immunity (ie, absolute lymphocyte count) and CD14+ HLA-DRlow/neg immunosuppressive monocytes (ie, absolute monocyte count) is a prognostic factor for patients with diffuse large B-cell lymphoma after autologous peripheral hematopoietic stem cell transplantation (APHSCT). Thus, we set out to investigate if A-LMR can also affect survival post-APHSCT in classical Hodgkin lymphoma. From 1994 to 2012, 183 patients with classical Hodgkin lymphoma who underwent APHSCT were studied. The patients were randomly divided into a training set (n=122) and a validation set (n=61). The receiver operating characteristic and area under the curve identified an A-LMR ?1 as the best cut-off value and validated by the k-fold cross-validation in the training set. Multivariate analysis showed A-LMR to be an independent prognostic factor for survival in the training set. Patients with an A-LMR ?1.0 experienced a superior overall survival (OS) versus patients with an A-LMR <1.0 (median OS not reached versus 40.4 months, 5-year OS rates of 86% [95% CI 72–93] versus 43% [95% CI 28–58], P<0.0001, respectively) in the training set. In the validation set, an A-LMR ?1 showed a median OS of not reached versus 41.4 months for an A-LMR <1, 5-year OS rates of 90% (95% CI 73–97) versus 48% (95% CI 28–68; P<0.0001). A-LMR provides a platform to engineer an autograft versus tumor effect to improve clinical outcomes in patients with classical Hodgkin lymphoma undergoing APHSCT. PMID:25674021

Porrata, Luis F; Inwards, David J; Ansell, Stephen M; Micallef, Ivana N; Johnston, Patrick B; Hogan, William J; Markovic, Svetomir N

2015-01-01

13

[Chinese classical formulas for treatment of essential hypertension].  

PubMed

Essential hypertension is one of the most prevalent and important public health concerns in both westernized and developing countries. Recent studies have demonstrated that successful long-term treatment of hypertension has a significant impact on morbidity and mortality from cardiovascular diseases (CVDs) and stroke. Chinese classical formulas, which are important components of traditional Chinese medicine (TCM), have been increasingly accepted by patients with CVDs worldwide. According to TCM theory and syndrome differentiation, hypertension could be categorized into 3 patterns including fire syndrome, fluid retention syndrome, and deficiency syndrome. Chinese classical formulas, including Chaihu Jia Longgu Muli tang, Tianma Gouteng yin, Zhen Gan Xifeng tang, Banxia Baizhu Tianma tang, Liu Wei Dihuang wan, etc, play an important role in the treatment of essential hypertension, which could be further research priorities. PMID:25204193

Xiong, Xing-Jiang; Wang, Jie

2014-03-01

14

Classical Chinese Landscape Painting and the Aesthetic Appreciation of Nature  

ERIC Educational Resources Information Center

Recent theories of the aesthetic appreciation of nature or natural environments have done much to clarify what might be essential to such appreciation. Such accounts are incomplete, however, as they depend on a strict separation between works of art and nature itself. This paper shows how classical Chinese landscape painting offers a way to…

Turner, Matthew

2009-01-01

15

Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma.  

PubMed

Hodgkin and Reed-Sternberg (H-RS) cells of classical Hodgkin lymphoma (cHL) present an impaired expression of immunoglobulin genes, but escape apoptotic death. We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases, whereas NOS3 expression was not detected. Positive associations were found between NOS1 and p53, bax and NOS2, bcl-2 and NOS2, bax and p53, and between bax and fasL. Inverse correlations were established between EBV and NOS2 and between EBV and bcl-2. A shorter overall survival (OS) was associated with strong expression of NOS2. In conclusion, NOS are expressed by H-RS cells of cHL. PMID:18830569

Campos, Antônio H J F M; Aldred, Vera L; Ribeiro, Karina C B; Vassallo, José; Soares, Fernando A

2009-01-01

16

Clinicopathological analysis of mediastinal large B-cell lymphoma and classical Hodgkin lymphoma of the mediastinum.  

PubMed

Primary mediastinal (thymic) large B-cell lymphoma (PMLBCL) and nodular sclerosing classical Hodgkin lymphoma (NSCHL) are the major histological types of lymphoma affecting the mediastinum. We reviewed 27 patients with PMLBCL and 14 patients with NSCHL. A poor performance status, high serum lactate dehydrogenase level and strong positivity for PAX5 were all significantly more common in patients with PMLBCL than in those with NSCHL. Severe fibrosis was frequent in NSCHL, but not in PMLBCL. PDL1 was expressed by 11/25 PMLBCLs (44.0%) vs. 1/9 NSCHLs (11.1%). Expression of BCL6 was significantly more frequent in PDL1-positive PMLBCL than in PDL1-negative PMLBCL, but there were no clinical differences between these two groups. Two patients with PMLBCL with a poor prognosis had CD20(-), CD79a(+), CD15(-), and CD30(-), possibly representing a subtype of mediastinal gray zone lymphoma. PMID:23020783

Yamamoto, Wataru; Nakamura, Naoya; Tomita, Naoto; Ishii, Yoshimi; Takasaki, Hirotaka; Hashimoto, Chizuko; Motomura, Shigeki; Yamazaki, Etsuko; Ohshima, Rika; Numata, Ayumi; Ishigatsubo, Yoshiaki; Sakai, Rika

2013-05-01

17

The prognostic value of interim positron emission tomography scan in patients with classical Hodgkin lymphoma.  

PubMed

The prognostic value of interim positron emission tomography (PET) was evaluated after 2 cycles of doxorubicin, bleomycin, vinblastin and dacarbazine in classical Hodgkin lymphoma patients (n = 229), based on Deauville criteria. In early stage non-bulky disease, bulky stage II disease, advanced stage low International Prognostic Score (IPS ?2) and advanced stage (IPS ?3), 3-year progression-free survival rates in PET2-negative vs. PET2-positive groups were 95·9% vs. 76·9% (P < 0·0018), 83·3% vs. 20·0% (P = 0·017), 77·0% vs. 30·0% (P < 0·001) and 71·0% vs. 44·4%(P = 0·155), respectively. The outcome after positive PET2 was better than previously reported. The results from non-randomized studies of PET2-guided therapy would be valuable with careful interpretation. PMID:24386943

Oki, Yasuhiro; Chuang, Hubert; Chasen, Beth; Jessop, Aaron; Pan, Tinsu; Fanale, Michelle; Dabaja, Bouthaina; Fowler, Nathan; Romaguera, Jorge; Fayad, Luis; Hagemeister, Fredrick; Rodriguez, Maria Alma; Neelapu, Sattva; Samaniego, Felipe; Kwak, Larry; Younes, Anas

2014-04-01

18

Utility of LRF/Pokemon and NOTCH1 protein expression in the distinction between nodular lymphocyte-predominant Hodgkin lymphoma and classical Hodgkin lymphoma.  

PubMed

Classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) are considered separate entities with different prognosis and treatment. However, morphologic features can be similar and immunohistochemical studies are essential in the distinction; thus, determination of additional biomarkers is of utmost importance. LRF/Pokemon is a proto-oncogene, an interacting partner co-expressed with BCL6 in germinal centers and highly expressed in diffuse large B-cell lymphoma and follicular lymphoma. Conversely, loss of the LRF gene in mouse hematopoietic stem cells results in complete block of early B cell development with concomitant Notch de-repression, indicating its critical role in B versus T cell fate decision at the hematopoietic stem cell stage. For the first time, we show that LRF/Pokemon is predominantly expressed in NLPHL cases as is BCL6 with low to absent NOTCH1 protein expression; while Hodgkin Reed-Sternberg (HRS) cells in CHL show low to absent BCL6 and LRF/Pokemon expression with higher NOTCH1 expression. We illustrate a potential functional interaction between LRF and BCL6 in NLPHL pathogenesis, and differential expression of LRF/Pokemon and NOTCH1 proteins in CHL thus showing differential expression, making for an additional diagnostic marker and therapeutic target. PMID:24326827

Bohn, Olga; Maeda, Takahiro; Filatov, Alexander; Lunardi, Andrea; Pandolfi, Pier Paolo; Teruya-Feldstein, Julie

2014-02-01

19

Utility of LRF/Pokemon and NOTCH1 Protein Expression in the Distinction of Nodular Lymphocyte-Predominant Hodgkin Lymphoma and Classical Hodgkin Lymphoma  

PubMed Central

Classical Hodgkin lymphoma (CHL) and nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) are considered separate entities with different prognosis and treatment. However, morphologic features can be similar and immunohistochemical studies are essential in the distinction; thus, determination of additional biomarkers is of utmost importance. LRF/Pokemon is a protooncogene, an interacting partner co-expressed with BCL6 in germinal centers and highly expressed in diffuse large B-cell lymphoma and follicular lymphoma. Conversely, loss of the LRF gene in mouse hematopoietic stem cells results in complete block of early B cell development with concomitant Notch derepression, indicating its critical role in B versus T cell fate decision at the hematopoietic stem cell stage. For the first time, we show that LRF/Pokemon is predominantly expressed in NLPHL cases as is BCL6 with low to absent NOTCH1 protein expression; while Hodgkin Reed-Sternberg (HRS) cells in CHL show low to absent BCL6 and LRF/Pokemon expression with higher NOTCH1 expression. We illustrate a potential functional interaction between LRF and BCL6 in NLPHL pathogenesis, and differential expression of LRF/Pokemon and NOTCH1 proteins in CHL thus showing differential expression, making for an additional diagnostic marker and therapeutic target. PMID:24326827

Bohn, Olga; Maeda, Takahiro; Filatov, Alexander; Lunardi, Andrea; Pandolfi, Pier Paolo; Teruya-Feldstein, Julie

2014-01-01

20

Involvement of abdominal and pelvic lymph nodes in non-Hodgkin lymphoma: the nodal distribution in Chinese patients  

Microsoft Academic Search

Objective  To study the distribution of abdominal and pelvic lymphadenopathy in non-Hodgkin lymphoma (NHL) in Chinese patients.\\u000a \\u000a \\u000a \\u000a Methods  CT images of 241 NHL patients with abdominal and\\/or pelvic lymphadenopathy were reviewed. Among them, clinical and image data\\u000a from 96 patients fulfilled the requirements for the analysis: 1. Abdominal and\\/ or pelvic lymphadenopathy detected by CT in\\u000a untreated patients (n=74). 2. Recurrent patients:

Ning Wu; Ying Liu; Dongmei Lin; Yu Chen; Mulan Shi

2004-01-01

21

How I treat classical Hodgkin lymphoma in patients infected with human immunodeficiency virus.  

PubMed

HIV-associated classical Hodgkin lymphoma (HIV-cHL) is an important complication of HIV disease in the era of effective combination antiretroviral therapy (cART). Generally, newly diagnosed HIV-cHL should be managed with curative intent. With modern HIV therapeutics, HIV-cHL treatment outcomes are largely comparable to those of the background population with cHL (non-HIV-cHL). To achieve these outcomes, particular attention must be given to managing HIV. This management includes understanding HIV as a comorbid condition with a spectrum of impact that is unique to each patient. Meticulous attention to drug-drug interactions is required to avoid toxicity and pharmacokinetic effects that can undermine cure. Relapsed and refractory HIV-cHL poses additional therapeutic challenges. The standard management in this setting should also be based on that for non-HIV-cHL, and includes the use of salvage chemotherapy followed by autologous stem cell transplant in chemosensitive disease. The role of allogeneic hematopoietic stem cell transplant is less clear but may be useful in select cases. Newer agents with activity in cHL are being tested as part of primary and salvage therapy and are also highly relevant for HIV-cHL. PMID:25499453

Uldrick, Thomas S; Little, Richard F

2015-02-19

22

The classical Hodgkin lymphoma tumor microenvironment: macrophages and gene expression-based modeling.  

PubMed

Despite the high cure rate in classical Hodgkin lymphoma (CHL), more accurate tailoring of upfront treatment is required to maximize cure while avoiding unnecessary short- and long-term treatment side effects. To this end, the unique tumor microenvironment of CHL has been searched extensively for prognostic biomarkers. Beyond targeted immunohistochemistry (IHC) studies, gene expression profiling (GEP) of diagnostic whole tissue biopsies has allowed a de novo approach to biomarker discovery. Among numerous candidate biomarkers, an association between the number of tumor-associated macrophages in the microenvironment and outcomes after ABVD (doxorubicin + bleomycin + vinblastine + dacarbazine) chemotherapy emerged, and multiple subsequent studies have validated this biological relationship using IHC. These studies have also defined key aspects for macrophage interrogation, including the characteristics of the CD68 and CD163 antibodies, appropriate scoring methodologies, and the identification of specific patient populations in which macrophage IHC may not be prognostic. The GEP studies also led to the development of gene expression-based prognostic models for advanced-stage CHL, with new technologies allowing reliable gene expression quantitation using RNA from routinely produced formalin-fixed paraffin-embedded biopsies. The bridge to predictive biomarkers that can be used reliably to inform upfront treatment selection requires further studies to demonstrate that these biomarkers can identify robustly, at diagnosis, patients at high risk of treatment failure with ABVD and that this risk may be overcome using alternative treatments. PMID:25696847

Scott, David W; Steidl, Christian

2014-12-01

23

Racial/ethnic variation in EBV-positive classical Hodgkin lymphoma in California populations.  

PubMed

Epstein-Barr virus (EBV) is detected in the tumor cells of some but not all Hodgkin lymphoma (HL) patients, and evidence indicates that EBV-positive and -negative HL are distinct entities. Racial/ethnic variation in EBV-positive HL in international comparisons suggests etiologic roles for environmental and genetic factors, but these studies used clinical series and evaluated EBV presence by differing protocols. Therefore, we evaluated EBV presence in the tumors of a large (n = 1,032), racially and sociodemographically diverse series of California incident classical HL cases with uniform pathology re-review and EBV detection methods. Tumor EBV-positivity was associated with Hispanic and Asian/Pacific Islander (API) but not black race/ethnicity, irrespective of demographic and clinical factors. Complex race-specific associations were observed between EBV-positive HL and age, sex, histology, stage, neighborhood socioeconomic status (SES), and birth place. In Hispanics, EBV-positive HL was associated not only with young and older age, male sex, and mixed cellularity histology, but also with foreign birth and lower SES in females, suggesting immune function responses to correlates of early childhood experience and later environmental exposures, respectively, as well as of pregnancy. For APIs, a lack of association with birth place may reflect the higher SES of API than Hispanic immigrants. In blacks, EBV-positive HL was associated with later-stage disease, consistent with racial/ethnic variation in certain cytokine polymorphisms. The racial/ethnic variation in our findings suggests that EBV-positive HL results from an intricate interplay of early- and later-life environmental, hormonal, and genetic factors leading to depressed immune function and poorly controlled EBV infection. PMID:18646185

Glaser, Sally L; Gulley, Margaret L; Clarke, Christina A; Keegan, Theresa H; Chang, Ellen T; Shema, Sarah J; Craig, Fiona E; Digiuseppe, Joseph A; Dorfman, Ronald F; Mann, Risa B; Anton-Culver, Hoda; Ambinder, Richard F

2008-10-01

24

Macrophages and Dendritic Cells as Actors in the Immune Reaction of Classical Hodgkin Lymphoma  

PubMed Central

Background The inflammatory infiltrate plays a pivotal role in classical Hodgkin lymphoma (cHL). Here, we focussed on the role of macrophages (M?) and dendritic cells (DC). Methods M? and DC infiltration was investigated in 106 cHL specimens using immunohistochemistry and cytokine expression was analyzed in a subset by real-time PCR. Human peripheral blood-derived monocytes, DC, M? stimulated with GM-CSF (M?GM-CSF, pro-inflammatory M?-1-model) or M-CSF (M?M-CSF, immunomodulatory M?-2-model) were incubated with cHL cell line (L1236, HDLM2) supernatants (SN). DC maturation or M? polarization were investigated by flow cytometry. Furthermore, the impact of DC or M? on cHL cell proliferation was analyzed by BrdU/CFSE assay. Results In cHL tissues mature myeloid (m)DC and M? predominated. High numbers of CD83+ mDC and low numbers of CD163+ M? were associated with improved disease specific survival. In numerous cHL specimens increased levels of both pro- and anti-inflammatory cytokines and of IL13 and GM-CSF were observed compared to reactive lymphadenopathies. Maturation of DC and induction and maintenance of an immunomodulatory M? phenotype were promoted by SN derived from cHL cell lines. TNF? neutralization in SN resulted in a significant inhibition of mDC maturation. DC and pro-inflammatory M? inhibited the proliferation of cHL cells. Conclusion Adopting an immunomodulatory phenotype is a potential mechanism for how M? promote immune evasion in cHL. Mature DC, in contrast, might participate in antitumoral immunity. PMID:25470820

Tudor, Christiane Silke; Bruns, Heiko; Daniel, Christoph; Distel, Luitpold Valentin; Hartmann, Arndt; Gerbitz, Armin; Buettner, Maike Julia

2014-01-01

25

Insulin-Like Growth Factor 1 Receptor Is a Prognostic Factor in Classical Hodgkin Lymphoma  

PubMed Central

The interaction between the tumor cells in classical Hodgkin lymphoma (cHL) and the microenvironment includes aberrant activity of receptor tyrosine kinases. In this study we evaluated the expression, functionality and prognostic significance of Insulin-like growth factor-1 receptor (IGF-1R) in cHL. IGF-1R was overexpressed in 55% (44/80) of cHL patients. Phosphorylated IGF-1R was detectable in a minority of the IGF-1R positive tumor cells. The overall survival (OS, 98%) and 5-year progression-free survival (PFS, 93%) was significantly higher in IGF-1R positive cHL patients compared to IGF-1R negative patients (OS 83%, p?=?.029 and PFS 77%, p?=?.047, respectively). Three cHL cell lines showed expression of IGF-1R, with strong staining especially in the mitotic cells and expression of IGF-1. IGF-1 treatment had a prominent effect on the cell growth of L428 and L1236 cells and resulted in an increased phosphorylation of IGF1R, Akt and ERK. Inhibition of IGF-1R with cyclolignan picropodophyllin (PPP) decreased cell growth and induced a G2/M cell cycle arrest in all three cell lines. Moreover, a decrease in pCcd2 and an increase in CyclinB1 levels were observed which is consistent with the G2/M cell cycle arrest. In conclusion, IGF-1R expression in HRS cells predicts a favorable outcome, despite the oncogenic effect of IGF-1R in cHL cell lines. PMID:24489919

Liang, Zheng; Diepstra, Arjan; Xu, Chuanhui; van Imhoff, Gustaaf; Plattel, Wouter; Van Den Berg, Anke; Visser, Lydia

2014-01-01

26

Detection of clonal T-cell receptor gamma-chain gene rearrangements in Reed-Sternberg cells of classic Hodgkin disease  

Microsoft Academic Search

Recent molecular single-cell studies have shown that in approximately 95% of cases, Reed-Sternberg cells of classic Hodgkin disease (HD) are derived from B cells of germinal center origin. Attempts to determine the cellular nature of the remaining cases have so far failed. To clarify whether they are derived from T cells, this study examined 791 single CD301 Hodgkin and Reed-Sternberg

Volkhard Seitz; Michael Hummel; Theresa Marafioti; Ioannis Anagnostopoulos; Chalid Assaf; Harald Stein

27

Treatment Options for Childhood Hodgkin Lymphoma  

MedlinePLUS

... Search for Clinical Trials NCI Publications Español Childhood Hodgkin Lymphoma Treatment (PDQ®) Treatment Options for Children and Adolescents with Hodgkin Lymphoma Low-Risk Classical Childhood Hodgkin Lymphoma Treatment ...

28

BOB.1-positive Classical Hodgkin’s Lymphoma Carries Hypermethylation of Its Promoter as Epigenetic Marker of Gene-silencing Memory  

PubMed Central

Analysis of archival formalin-fixed, paraffin-embedded (FFPE) pathological specimens of three case of Epstein-Barr virus (EBV)-positive diffuse large B-cell lymphoma (DLBCL) and three cases of classical Hodgkin lymphoma (CHL) revealed that hypermethylation of the BOB.1 gene promoter was exclusively observed in CHL. A discrepancy was observed, however, between the methylation status of the BOB.1 gene promoter and its expression in the EBV-positive mixed cellular CHL (MCCHL). Since MCCHL lacks the typical B-cell phenotype even in the presence of abundant BOB.1 transcription factors, functional activity of BOB.1 may be lost or reduced by a mechanism other than epigenetic gene silencing. When some tumor-suppressor gene products have lost their biological function, impact or significance of derepression of such genes may be little. Therefore, when interpreting immunohistochemical results for diagnostic or research purposes, it must be borne in mind that apparent positive immunostaining can merely be the result of chromatin remodeling and that such transient expression often has little functional significance. Any apparent positive immunohistochemical result needs to be interpreted carefully with the help of the hypermethylation status as a molecular marker of gene silencing memory. PMID:25320409

Watanabe, Takafumi; Kitazawa, Riko; Mizuno, Yosuke; Kuwahara, Natsumi; Ito, Chizu; Sugita, Atsuro; Haraguchi, Ryuma; Kitazawa, Sohei

2014-01-01

29

Risk assessment in the management of newly diagnosed classical Hodgkin lymphoma.  

PubMed

Treatment of Hodgkin lymphoma is associated with 2 major types of risk: that the treatment may fail to cure the disease or that the treatment will prove unacceptably toxic. Careful assessment of the amount of the lymphoma (tumor burden), its behavior (extent of invasion or specific organ compromise), and host related factors (age; coincident systemic infection; and organ dysfunction, especially hematopoietic, cardiac, or pulmonary) is essential to optimize outcome. Elaborately assembled prognostic scoring systems, such as the International Prognostic Factors Project score, have lost their accuracy and value as increasingly effective chemotherapy and supportive care have been developed. Identification of specific biomarkers derived from sophisticated exploration of Hodgkin lymphoma biology is bringing promise of further improvement in targeted therapy in which effectiveness is increased at the same time off-target toxicity is diminished. Parallel developments in functional imaging are providing additional potential to evaluate the efficacy of treatment while it is being delivered, allowing dynamic assessment of risk during chemotherapy and adaptation of the therapy in real time. Risk assessment in Hodgkin lymphoma is continuously evolving, promising ever greater precision and clinical relevance. This article explores the past usefulness and the emerging potential of risk assessment for this imminently curable malignancy. PMID:25575542

Connors, Joseph M

2015-03-12

30

Relationship of intratumoural protein expression patterns to age and Epstein-Barr virus status in classical Hodgkin lymphoma.  

PubMed

In Western countries, the age distribution of Hodgkin lymphoma (HL) follows a characteristic bimodal curve showing an early and a late peak at approximately 35 and 70 yr, respectively. Furthermore, the presence of latent Epstein-Barr virus (EBV) genome in the Hodgkin Reed-Sternberg cells, the tumour cell population of classical HL (cHL), has been found to have adverse prognostic impact in elderly, but not in younger cHL patients. We have characterised the protein expression in tumour tissue samples from younger (?55 yr) and elderly (>55 yr) cHL patients and correlated the findings with EBV status. Differentially expressed proteins according to patients' age as well as tumoural EBV status belonged to different biological functional domains, such as apoptosis, cytoskeletal organisation, response to oxygen levels and regulation of catabolic/metabolic processes. The differential expression of selected proteins, cytosolic aminopeptidase, heterogeneous nuclear ribonucleoprotein K, serotransferrin and alpha-1-antitrypsin was further validated by Western blot analysis. Discovery-based proteomics characterising biological features distinctive for subsets of cHL patients may be useful for the identification of novel biomarkers with potential therapeutic relevance. An evaluation of the prognostic impact of protein expression pattern in general and individually expressed proteins in particular is warranted. PMID:25307790

Ludvigsen, Maja; Kamper, Peter; Hamilton-Dutroit, Stephen J; Bendix, Knud; Møller, Michael B; d'Amore, Francesco A; Honoré, Bent

2014-10-11

31

Mapping of transcription factor motifs in active chromatin identifies IRF5 as key regulator in classical Hodgkin lymphoma  

PubMed Central

Deregulated transcription factor (TF) activities are commonly observed in hematopoietic malignancies. Understanding tumorigenesis therefore requires determining the function and hierarchical role of individual TFs. To identify TFs central to lymphomagenesis, we identified lymphoma type-specific accessible chromatin by global mapping of DNaseI hypersensitive sites and analyzed enriched TF-binding motifs in these regions. Applying this unbiased approach to classical Hodgkin lymphoma (HL), a common B-cell–derived lymphoma with a complex pattern of deregulated TFs, we discovered interferon regulatory factor (IRF) sites among the top enriched motifs. High-level expression of the proinflammatory TF IRF5 was specific to HL cells and crucial for their survival. Furthermore, IRF5 initiated a regulatory cascade in human non-Hodgkin B-cell lines and primary murine B cells by inducing the TF AP-1 and cooperating with NF-?B to activate essential characteristic features of HL. Our strategy efficiently identified a lymphoma type-specific key regulator and uncovered a tumor promoting role of IRF5. PMID:25288773

Kreher, Stephan; Bouhlel, M. Amine; Cauchy, Pierre; Lamprecht, Björn; Li, Shuang; Grau, Michael; Hummel, Franziska; Köchert, Karl; Anagnostopoulos, Ioannis; Jöhrens, Korinna; Hummel, Michael; Hiscott, John; Wenzel, Sören-Sebastian; Lenz, Peter; Schneider, Markus; Küppers, Ralf; Scheidereit, Claus; Giefing, Maciej; Siebert, Reiner; Rajewsky, Klaus; Lenz, Georg; Cockerill, Peter N.; Janz, Martin; Dörken, Bernd; Bonifer, Constanze; Mathas, Stephan

2014-01-01

32

Why Chinese People Play Western Classical Music: Transcultural Roots of Music Philosophy  

ERIC Educational Resources Information Center

This paper addresses the complex relationship between Confucian values and music education in East Asia, particularly its history in China. How does one account for the present "cultural fever" of Western classical music that has infected more than 100 million Chinese practitioners? It is proposed that Western classical music finds transcultural…

Huang, Hao

2012-01-01

33

Socioeconomic inequality in the use of rituximab therapy among non-Hodgkin lymphoma patients in Chinese public hospitals.  

PubMed

Rituximab is a patient-paid effective monoclonal-antibody drug for non-Hodgkin lymphoma (NHL). Little is known in China, a country with unequal distribution of wealth and medical insurance systems, about the impact of socioeconomic status (SES) on selecting rituximab therapy in NHL patients. A total of 328 NHL inpatients in 2 public hospitals in Hangzhou were recruited and divided into 2 equal groups: with rituximab therapy and with no rituximab therapy group. Selection and frequency of rituximab therapy increased with duration of education and in urban citizens (P < .01). Officers and businessmen were more likely to use rituximab therapy compared with farmers (P < .01). Patients covered by Urban Employee Basic Medical Insurance were more likely to select rituximab therapy than those insured with Urban-Rural Residents Basic Medical Insurance (P < .01). There was an inequality in provision of rituximab therapy among Chinese NHL patients, and this was associated with differences in SES status. Effective measures are suggested to ameliorate the inequality issue. PMID:23162009

Yu-Wen, Huang; Mei-Bian, Zhang; Xiang, Xu; Xiao-Hua, Xu; Quan, Zhou; Le, Jian

2014-03-01

34

B cells in classical Hodgkin lymphoma are important actors rather than bystanders in the local immune reaction.  

PubMed

Recent studies, largely focusing on cellular immunity, have demonstrated that the composition of the abundant inflammatory background of Hodgkin lymphoma may affect outcome. This investigation aimed to characterize the potential role of infiltrating B cells and follicular dendritic cell networks in classical Hodgkin lymphoma (cHL) to better assess the role of components of humoral immunity. One hundred two cHL biopsies were investigated by immunohistochemistry with antibodies specific for CD20, CD138, activation-induced cytidine deaminase, and CD21 to characterize B cell distribution and follicular structures. To further subclassify B cells, analyses of tissue microarrays were performed investigating the expression of Mum1, Bcl6, IgD, IgG, IgG4, IgM, T-bet, CD38, CD5, and CD10. For evaluation a computer assisted quantification method was compared with a scoring system. Survival analysis and correlation analysis were performed. The B cell infiltrate was dominated by CD20+ B cells, followed by plasma cells, whereas only few AID+ cells were observed. High numbers of CD21+ follicular dendritic cell networks, CD20+ B cells, IgM+ cells, CD20+ aggregates, and Bcl6+ cells were associated with a better outcome of cHL patients, whereas Pax5+/CD38+ cells had an adverse prognostic impact. Other parameters showed no influence on survival. Our findings suggest that a complex network of B cells is present in the microenvironment of cHL and that B cells might actively contribute to a local anti- as well as pro-tumoral immune response. This indicates that the network of B cells in tumors is probably just as diverse as the T cellular infiltrate and probably functionally as heterogenous. PMID:24029709

Tudor, Christiane S; Distel, Luitpold V; Eckhardt, Jenny; Hartmann, Arndt; Niedobitek, Gerald; Buettner, Maike

2013-11-01

35

Harvard Yen-ching Classification 0100 to 0999 Chinese Classics  

E-print Network

-1609 Logic 1610-1649 Metaphysics 1650-1699 Ethics 1700-1729 Religion in general 1730-1738 Mythology 1739-1749 Occultism numerology 1750-1779 History of religions 1780-1799 Chinese state cults 1800-1919 Buddhism 1920

California at Berkeley, University of

36

A Chinese patient with relapsed and refractory Hodgkin lymphoma treated with brentuximab vedotin  

PubMed Central

At present, approximately 20% of Hodgkin lymphomas (HL) are relapsed and refractory, and therapeutic methods including chemotherapy, radiotherapy, and even stem cell transplantation are unsatisfactory. Brentuximab vedotin, composed of CD30 antibody and a chemotherapeutic agent, is a new targeted drug that eradicates tumor cells by binding to the CD30 antigen on their surface. In clinical trials, the response rate and complete remission rate of this drug were 73% and 40%, respectively, for relapsed and refractory HL. Here we report a case of CD30-positive relapsed and refractory HL that was treated with brentuximab. Before the treatment with brentuximab, the patient underwent chemotherapy, radiotherapy, and autologous stem cell transplantation. However, the disease continued to progress, affecting multiple organs and prompting symptoms such as persistent fever. After the treatment with brentuximab, the patient's condition improved. Body temperature returned to normal after 4 days. Lung nodules were reduced in size and number after a single course of treatment, and PET/CT showed partial remission and complete remission after 3 and 6 courses of treatment, respectively. The entire treatment process progressed smoothly, though the patient experienced some symptoms due to chemotherapy, including peripheral neuritis of the limbs, irritating dry cough, and mild increase in aminotransferase. No serious adverse effects were observed. The current general condition of the patient is good; the continuous complete remission has amounted to 6 months. PMID:23544448

Cao, Zhi-Gang; Zhou, Hong-Wei; Peng, Chao-Jin; Liu, Mo; Du, Yu; Yang, Qing-Ming

2013-01-01

37

The molecular signature of mediastinal large B-cell lymphoma differs from that of other diffuse large B-cell lymphomas and shares features with classical Hodgkin lymphoma  

Microsoft Academic Search

Mediastinal large B-cell lymphoma (MLBCL) is a recently identified subtype of diffuse large B-cell lymphoma (DLBCL) that char- acteristically presents as localized tu- mors in young female patients. Although MLBCL has distinctive pathologic fea- tures, it clinically resembles the nodular sclerosis subtype of classical Hodgkin lymphoma (cHL). To elucidate the molecu- lar features of MLBCL, we compared the gene expression

Kerry J. Savage; Stefano Monti; Jeffery L. Kutok; Giorgio Cattoretti; Donna Neuberg; Laurence de Leval; Paul Kurtin; Paola Dal Cin; Christine Ladd; Friedrich Feuerhake; Ricardo C. T. Aguiar; Sigui Li; Gilles Salles; Francoise Berger; Wen Jing; Geraldine S. Pinkus; Thomas Habermann; Riccardo Dalla-Favera; Lee Harris; Jon C. Aster; Todd R. Golub; Margaret A. Shipp

2003-01-01

38

Tumor-associated macrophages predict inferior outcomes in classic Hodgkin lymphoma: a correlative study from the E2496 Intergroup trial.  

PubMed

Increased tumor-associated macrophages (TAMs) are reported to be associated with poor prognosis in classic Hodgkin lymphoma (CHL). We investigated the prognostic significance of TAMs in the E2496 Intergroup trial, a multicenter phase 3 randomized controlled trial comparing ABVD and Stanford V chemotherapy in locally extensive and advanced stage CHL. Tissue microarrays were constructed from formalin-fixed, paraffin-embedded tumor tissue and included 287 patients. Patients were randomly assigned into training (n = 143) and validation (n = 144) cohorts. Immunohistochemistry for CD68 and CD163, and in situ hybridization for EBV-encoded RNA were performed. CD68 and CD163 IHC were analyzed by computer image analysis; optimum thresholds for overall survival (OS) were determined in the training cohort and tested in the independent validation cohort. Increased CD68 and CD163 expression was significantly associated with inferior failure-free survival and OS in the validation cohort. Increased CD68 and CD163 expression was associated with increased age, EBV-encoded RNA positivity, and mixed cellularity subtype of CHL. Multivariate analysis in the validation cohort showed increased CD68 or CD163 expression to be significant independent predictors of inferior failure-free survival and OS. We demonstrate the prognostic significance of TAMs in locally extensive and advanced-stage CHL in a multicenter phase 3 randomized controlled clinical trial. PMID:22948049

Tan, King L; Scott, David W; Hong, Fangxin; Kahl, Brad S; Fisher, Richard I; Bartlett, Nancy L; Advani, Ranjana H; Buckstein, Rena; Rimsza, Lisa M; Connors, Joseph M; Steidl, Christian; Gordon, Leo I; Horning, Sandra J; Gascoyne, Randy D

2012-10-18

39

Why Study Chinese Classics and How to Go about It: Response to Zongjie Wu's "Interpretation, Autonomy, and Transformation--Chinese Pedagogic Discourse in Cross-Cultural Perspective"  

ERIC Educational Resources Information Center

This response to Zongjie Wu's "Interpretation, autonomy, and interpretation" focuses on the "battle between East and West" which contextualizes Wu's proposal to counter the current Western domination of Chinese pedagogic discourse with an "authentic language" recovered from the Chinese classics. It points out that it is impossible and undesirable…

Tan, Sor-Hoon

2011-01-01

40

CD163 Expression Was Associated with Angiogenesis and Shortened Survival in Patients with Uniformly Treated Classical Hodgkin Lymphoma  

PubMed Central

Background Recent studies have reported the prognostic value of tissue-associated magrophages (TAMs) in classical Hodgkin lymphoma (cHL). In addition, TAMs are implicated in the tumor angiogenesis. In this study, we examined the prognostic relevance of TAMs in relation to vascular endothelial growth factor (VEGF) expression and angiogenesis in uniformly treated cases of cHL. Methods Diagnostic tissue from 116 patients with ABVD-treated cHL was evaluated retrospectively by immunohistochemical analysis for CD68, CD163 and VEGF expression and for CD31 expression as a measure of microvessel density (MVD). Results High CD163 expression (?35% of cellularity) correlated with VEGF expression (Pearson’s Chi-square test, P?=?0.008) and MVD (Spearman correlation coefficient 0.310, P<0.001). High CD163 expression was associated with inferior event-free survival (EFS, P?=?0.005) and overall survival (OS, P<0.001) in univariate analysis. In multivariate analysis, high CD163 expression was strongly associated with inferior EFS (P?=?0.043) and OS (P?=?0.008). Patients with high MVD had a lower OS than those with low MVD, but the difference was not significant (P?=?0.071, respectively). While high expression of CD68 was also associated with inferior EFS (P?=?0.007), it showed no correlation with VEGF or MVD. Conclusions Our data confirms that CD163 expression provides independent prognostic information in cHL. The correlation of CD163 with VEGF expression and MVD suggests the role of CD163-positive cells in tumor angiogenesis of cHL. PMID:24489836

Koh, Young Wha; Park, Chan-Sik; Yoon, Dok Hyun; Suh, Cheolwon; Huh, Jooryung

2014-01-01

41

A Web 2.0 Personal Learning Environment for Classical Chinese Poetry  

NASA Astrophysics Data System (ADS)

Classical Chinese Poetry (CCP) is a valuable but almost locked treasure chest of human wisdom and civilization since 2000 years. With the advent of the Web 2.0 a renaissance of CCP is possible even outside Chinese-speaking communities world-wide. With mobile technologies and educational games we can address new learning communities for CCP and open the chest again. In this paper, we introduce a Web 2.0 personal learning environment for CCP. We have developed a generic and interoperable data model for CCP we utilize not only for mobile learning scenarios but also for educational gaming with different levels of difficulty. Learners are empowered to learn Chinese poetry, language, history, and culture. This research work shows how modern information technologies assist users to diffuse knowledge across the borderlines of communities and societies.

Cao, Yiwei; Klamma, Ralf; Gao, Yan; Lau, Rynson W. H.; Jarke, Matthias

42

Shiyi and tiwu —On the artistic description tradition of Chinese classical poetry  

Microsoft Academic Search

This paper systematically surveys the shared artistic issues that arose in both poetry criticism and creative practice in\\u000a the Wei, Jin and the Northern and Southern dynasties and continued through the Tang and Song dynasties and up to the present\\u000a time. In this way the long-standing artistic tradition of tiwu ?? (embodying objects) in Chinese classic poetry, which has long

Jingtai Han

2009-01-01

43

Classical Hodgkin's lymphoma: the Lymphoma Study Association guidelines for relapsed and refractory adult patients eligible for transplant.  

PubMed

The Hodgkin's Lymphoma Committee of the Lymphoma Study Association (LYSA) gathered in 2012 to prepare guidelines on the management of transplant-eligible patients with relapsing or refractory Hodgkin's lymphoma. The working group is made up of a multidisciplinary panel of experts with a significant background in Hodgkin's lymphoma. Each member of the panel of experts provided an interpretation of the evidence and a systematic approach to obtain consensus was used. Grades of recommendation were not required since levels of evidence are mainly based on phase II trials or standard practice. Data arising from randomized trials are emphasized. The final version was endorsed by the scientific council of the LYSA. The expert panel recommends a risk-adapted strategy (conventional treatment, or single/double transplantation and/or radiotherapy) based on three risk factors at progression (primary refractory disease, remission duration < 1 year, stage III/IV), and an early evaluation of salvage chemosensitivity, including (18)fluorodeoxy glucose-positron emission tomography interpreted according to the Deauville scoring system. Most relapsed or refractory Hodgkin's lymphoma patients chemosensitive to salvage should receive high-dose therapy and autologous stem-cell transplantation as standard. Efforts should be made to increase the proportion of chemosensitive patients by alternating non-cross-resistant chemotherapy lines or exploring the role of novel drugs. PMID:23904236

Van Den Neste, Eric; Casasnovas, Olivier; André, Marc; Touati, Mohamed; Senecal, Delphine; Edeline, Véronique; Stamatoullas, Aspasia; Fornecker, Luc; Deau, Bénédicte; Gastinne, Thomas; Reman, Oumédaly; Gaillard, Isabelle; Borel, Cécile; Brice, Pauline; Fermé, Christophe

2013-08-01

44

Systematic review of recent advances in pharmacokinetics of four classical Chinese medicines used for the treatment of cerebrovascular disease.  

PubMed

Recent studies have focused more on Chinese medicine used for the treatment of cerebrovascular disease. The current review covers researches on the pharmacokinetics of Chinese medicine, providing a convenient reference for researchers to increase efficiency of drug discovery, by compiling and discussing the pharmacokinetics of four classical Chinese medicines for therapy of cerebrovascular disease containing: Panax notoginseng, Salvia miltiorrhiza, Ligusticum Chuanxiong and Gardenia. It also helps to eliminate side effect as far as possible from inappropriate Chinese medicine usage. Current integrative and comprehensive review of Chinese medicine for cerebrovascular disease including 1) the absorption of some constituents is limited such as ginsenosides Rg1 and Rb1. It may be affected by gastric juice, first-pass effect, etc. 2) The interactions between Chinese medicine and prescription can occur. Borneol and carbomer would enhance the absorption of R1 and Rg1 in vivo by increasing adjacent cell transport ability. 3) The distribution of active constituents in brain is important for cerebrovascular disease. BBB protects brain from xenobiotic. Intranasal, intra-tympanic administration is a promising alternative to conventional administration to reach brain for ligustrazine. 4) Renal excretion is the uppermost route of these Chinese medicines. But biliary, fecal and urinary excretion are the other major routes. Theoretical and practical aspects are described with pharmacokinetic examples. In the end, this paper also discusses recent development of bio-analysis of Chinese medicine. PMID:23602902

Zeng, Mingfei; Pan, Linmei; Qi, Shunmei; Cao, Yuntai; Zhu, Huaxu; Guo, Liwei; Zhou, Jing

2013-07-01

45

Hodgkin's disease  

SciTech Connect

The outlook for patients with Hodgkin's disease has improved dramatically over the past 20 years. The question is no longer whether cure is possible, but rather, how can cure be best achieved. With better understanding of the biology of Hodgkin's disease and with continued evolution of treatment approaches, the goal of curing all patients with Hodgkin's disease is clearly within reach. This article provides a summary of current concepts in the biology and management of Hodgkin's disease. Staging, treatment options, and complications of therapy are discussed.

Portlock, C.S.

1984-05-01

46

B cell lymphoma, unclassifiable, with features intermediate between diffuse large B cell lymphoma and classical hodgkin lymphoma: diagnosis by fine-needle aspiration cytology.  

PubMed

A 58-year-old lady presented with mediastinal lymphadenopathy. A thoracoscopic ultrasound-guided fine-needle aspiration showed large atypical epithelioid cells arranged in cohesive sheets and dispersed as single cells with intact cytoplasm amid a background of lymphocytes and histiocytes. A cytological diagnosis of "a malignant neoplasm" was made, raising a broad list of differential diagnoses. A broad panel of immunocytochemical stains performed on the cell block was indicative of a lymphoproliferative disorder, but the immunophenotype was intermediate between diffuse large B cell lymphoma (DLBCL) and classical Hodgkin lymphoma (cHL). Diffuse and strong reactivity to CD20, CD79a, and PAX-5, and weak reactivity to CD30, was in favor of a DLBCL, or more precisely mediastinal (thymic) large B cell lymphoma (MLBL). However, there were negative staining for LCA, OCT-2, and BOB-1 as well as positive staining for EBV-encoded RNA, which were against a diagnosis of MLBL and raised the possibility of cHL. The absence of RS cells and the typical mileu, the negativity for CD15 and the strong positivity of CD20 and PAX-5 were against a diagnosis of cHL. On this basis, the diagnosis of "B-cell lymphoproliferative disorder with features intermediate between DLBCL and cHL" was rendered. The diagnosis was subsequently confirmed on excisional biopsy. This case report demonstrates broad differential diagnoses raised by this diagnostic entity and the importance of an adequate cell block for accurate designation. PMID:23630122

Lynnhtun, Kyaw; Varikatt, Winny; Pathmanathan, Nirmala

2014-08-01

47

Risk of second malignancies in patients with early-stage classical Hodgkin's lymphoma treated in a modern era  

PubMed Central

Second malignancies remain an issue affecting morbidity and mortality in long-term survivors of early stage Hodgkin's lymphoma (HL). We undertook this study to determine if treatment in the modern era resulted in decreased second malignancies. Patients diagnosed with stage I–II cHL between 1988 and 2009 who received radiation therapy (RT) were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Freedom from second malignancy (FFSM) was estimated using the Kaplan–Meier method. Univariate analysis (UVA) was performed using the Log-Rank test, and included age, gender, year of diagnosis, and stage. Multivariable analysis (MVA) was performed using Cox Proportional Hazards modeling. The study cohort included 8807 patients. The median age at diagnosis was 32 years (range: 2–85). The majority of patients had stage II disease (n = 6044, 69%), 597 (7%) had extranodal involvement (ENI), and 1925 (22%) had B symptoms. Median follow-up for the entire cohort was 7.2 years (range: 0–22). Five hundred twenty-three (6%) patients developed a second malignancy. Median latency to second malignancy was 5.8 years (range: 0.1–21.5). Of the 523 patients that developed a second malignancy, 228 (44%) occurred in the first 5 years, 139 (27%) were diagnosed between years 5–10, and 156 (30%) beyond 10 years. The 10 year FFSM for patients treated between 1988 and 1999 was 93.0% versus 95.1% for patients treated between 2000 and 2009 (P = 0.04), On MVA, treatment between 2000 and 2009 was associated with a HR for second malignancy of 0.77 (95% Confidence Interval: 0.62–0.96, P = 0.02) compared to the treatment between 1988 and 1999. Our analysis suggests that in patients treated with RT for stage I or II cHL, treatment prior to 2000 had a slightly higher risk of second malignancy compared to treatment in 2000 and later. Further studies, with longer follow-up of patients treated in the modern era are needed to confirm these findings. PMID:25620577

LeMieux, Melissa H; Solanki, Abhishek A; Mahmood, Usama; Chmura, Steven J; Koshy, Matthew

2015-01-01

48

Transliteration Extraction from Classical Chinese Buddhist Literature Using Conditional Random Fields  

E-print Network

, Zhongli City, Taiwan thtsai@csie.ncu.edu.tw Abstract Extracting plausible transliterations from historical" has several different Chinese transliterations such as "" (zhu-li-pan-te) and " " (zhou-li-pan

49

Non-Hodgkin lymphoma  

MedlinePLUS

Lymphoma - non-Hodgkin; Lymphocytic lymphoma; Histiocytic lymphoma; Lymphoblastic lymphoma; Cancer - non-Hodgkin lymphoma ... National Cancer Institute: PDQ Adult Non-Hodgkin Lymphoma ... Available at http://www.cancer.gov/cancertopics/pdq/treatment/ ...

50

Accounting and management controls in the classical Chinese novel: A Dream of the Red Mansions  

Microsoft Academic Search

This study presents a systematic documentation of Chinese accounting and management control practices in two eminent family households of the early Qing Dynasty. There is a lack of information on management control during this period (during the 18th century) and a scarcity of empirical evidence on the control practices of family institutions in ancient China. We attempted to address these

K. Hung Chan; Albert Y. Lew; Marian Yew Jen Wu Tong

2001-01-01

51

Philology and Its Enemies: Changing Views of Late Imperial Chinese Classicism  

E-print Network

increasingly challenge this stereo- type.6 Another is: "Confucianism provided a liberal vision of human agency-17, 2006 In the late twentieth century, a new generation of scholars has placed Chinese "Confucianism" and "hermeneutics." However useful these new conceptualiza- tions of Confucianism in China might be, they are also

Elman, Benjamin

52

Management of Lymphocyte Predominant Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a Lymphocyte-predominant Hodgkin lymphoma (LPHL) is a rare disease that is distinct from other types of Hodgkin lymphoma (HL)\\u000a histologically and clinically. Historically, LPHL was treated similar to classical HL. However, over time, it was recognized\\u000a that LPHL is highly responsive to treatment (>90% achieve complete response [CR]) and rarely fatal. More LPHL patients die\\u000a from other causes, including iatrogenic causes

Ronald C. Chen; Peter M. Mauch

53

Chinese Mathematics  

NSDL National Science Digital Library

The School of Mathematics and Statistics at the University of St. Andrews Scotland offers this website on the history of Chinese Mathematics. Key features highlighted in the overview include: a discussion of the Chinese version of Pythagoras's theorem, a famous Chinese mathematics book commonly known as the Nine Chapters on the Mathematical Art, and the work of several Chinese mathematicians. Visitors to the website can also browse a chronological listing of several Chinese mathematicians and read about their careers. Other features of the website include a section summarizing each chapter from the Nine Chapters on the Mathematical Art, a section highlighting ten other mathematical classics, a review of the Chinese numeral system, and a collection of Chinese problems, which are extracted from various articles in their archive.

54

Comparison of positron emission tomography/computed tomography with classical contrast-enhanced computed tomography in the initial staging of Hodgkin lymphoma.  

PubMed

We compared initial computed tomography (CT) and positron emission tomography (PET)/CT in 96 patients with Hodgkin lymphoma (HL), assessing the role of baseline PET/CT in stage migration and treatment selection. The number of patients with stage I, II, III and IV disease based on CT versus PET/CT was: 5 vs. 7, 49 vs. 37, 28 vs. 22 and 14 vs. 30, respectively. In 33 (34%) patients, PET/CT changed HL stage: 27 (28%) were upstaged and six (6.3%) downstaged. Upstaging was caused by detection of new extranodal involvements (47 sites in 26 patients): bone marrow (10 patients), spleen (five patients) and lung (two patients). In nine patients?2 further coexisting locations were detected. Downstaging resulted from the absence of fluorodeoxyglucose (18F-FDG) uptake in enlarged nodes (>15 mm) in the abdomen and pelvis. PET/CT modified HL stage in 34% of patients leading to treatment modification in the majority. Our results indicate that PET/CT should be mandatory in the initial staging of HL. PMID:24794802

Bednaruk-M?y?ski, Ewa; Pie?kowska, Joanna; Skórzak, Adam; Ma?kowski, Bogdan; Kulikowski, Waldemar; Subocz, Edyta; Dzietczenia, Justyna; Zalewska, Marta; Le?niewski-Kmak, Krzysztof; Zaucha, Renata; Wróbel, Tomasz; Zaucha, Jan M

2015-02-01

55

Hodgkin Lymphoma in Adults (Beyond the Basics)  

MedlinePLUS

... treatment of advanced (stage III-IV) classical Hodgkin lymphoma" .) Most people with stage III and IV disease will be given the ABVD regimen. With this, 60 to 70 percent of patients will be alive and free of disease at five years. ABVD alone is the treatment of choice ...

56

CD163 and c-Met expression in the lymph node and the correlations between elevated levels of serum free light chain and the different clinicopathological parameters of advanced classical Hodgkin's lymphoma  

PubMed Central

Background Advances in the understanding of Hodgkin's lymphoma (HL) show various functions of infiltrating immune cells and cytokines in relation to clinical outcomes. The expression of CD163 and c-Met has been suggested to have a role in lymphoid malignancy. Thus, we evaluated the expressions of CD163, c-Met, and serum free light chain (sFLC) in relation to the clinicopathological features of patients with advanced classical HL (cHL). Methods We assessed the expression of CD163 and c-Met in 34 patients with cHL through immunohistochemistry on the lymph node biopsy sections and the levels of pretreatment sFLC were estimated using ELISA. Results High CD163 expression correlated with increased age, B symptoms, International Prognostic Score (IPS) ?3, mixed cellularity subtype, and low response to treatment. Further, high c-Met expression correlated with increased age at diagnosis, leukocytosis, B symptoms, and lower chance to achieve complete remission. The sFLC levels correlated with increased age at diagnosis, lymphopenia, IPS ?3, B symptoms, and lower complete remission rates. Conclusion In advanced cHL, increased expression of CD163 and c-Met showed a significant association with adverse prognostic parameters and poor response to treatment. Pretreatment high sFLC level also correlated with poor risk factors, suggesting its use as a candidate prognostic marker. A comprehensive approach for prognostic markers might represent a step towards developing a tailored therapeutic approach for HL. PMID:23826581

Bedewy, Magdy; El-Maghraby, Shereen

2013-01-01

57

Stages of Childhood Hodgkin Lymphoma  

MedlinePLUS

Stages of Childhood Hodgkin Lymphoma Key Points for This Section After childhood Hodgkin lymphoma has been diagnosed, tests are done to find out ... lymphoma is divided into risk groups. After childhood Hodgkin lymphoma has been diagnosed, tests are done to ...

58

The Interrelationship of Chinese Music and Poetry  

Microsoft Academic Search

Unlike its Western counterpart, Chinese poetry has a more important role in Chinese literary history, especially classical Chinese poetry, which dominated literature as well as art throughout history. However, when making an intratextual analysis of this genre, we find the generic roots of classical Chinese poetry have stemmed from music. The studies of the dichotomous nature of Chinese poetry and

YANPING WANG

59

Primary gastric Hodgkin's lymphoma  

Microsoft Academic Search

BACKGROUND: Primary Hodgkin's disease of the stomach is an extremely rare entity. Nearly all cases of primary gastric lymphoma are of the non-Hodgkin's variety. Diagnoses in such cases are difficult due to considerable histological similarities between the 2 disease entities. CASE PRESENTATION: We report the case of a 77 year old lady with a 1 year history of weight loss

Fahad S Hossain; Yashwant Koak; Farrukh H Khan

2007-01-01

60

Treatment Options for Adult Hodgkin Lymphoma  

MedlinePLUS

... Search for Clinical Trials NCI Publications Español Adult Hodgkin Lymphoma Treatment (PDQ®) Treatment Options for Adult Hodgkin Lymphoma Early Favorable Hodgkin Lymphoma Treatment of early favorable ...

61

Dorothy Crowfoot Hodgkin  

NASA Astrophysics Data System (ADS)

Born in 1910 in Cairo, Egypt, Dorothy Crowfoot Hodgkin would later be known as the third woman in history to win the Nobel Prize in Chemistry for her research on the structure of vitamin B-12. Her X-ray crystallography work also included discovering the molecular structure of penicillin and insulin. Dr. Hodgkin's work has aided in determining the structures of molecules for others to expand the technology necessary for today's medicine.

Montalvo, Jessica

2009-10-01

62

Vorinostat in Treating Patients With Relapsed or Refractory Advanced Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Favorable Prognosis Hodgkin Lymphoma; Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Adult Unfavorable Prognosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2014-05-07

63

Lymphome de Hodgkin  

Microsoft Academic Search

With approximately 1500 cases per year in France, Hodgkin's lymphoma (HL) represents only 10 to 15 % of new cases of lymphomas, and 0.5 to 1 % of new cases of cancers. The management of this lymphoproliferative disease has undergone profound conceptual changes over time, allowing at present to obtain a cure rate of 75 to 80 % of all

F. Drouet; X. Cahu; Y. Pointreau; F. Denis; M. A. Mahé

2010-01-01

64

Non-Hodgkin Lymphoma (For Parents)  

MedlinePLUS

... harmful substances out of the body. About Non-Hodgkin Lymphoma Non-Hodgkin lymphoma is a disease in which cancer cells ... cells) and are grouped under the heading of Hodgkin lymphoma. All other forms of lymphoma fall into ...

65

SGN-30 and Combination Chemotherapy in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2015-02-10

66

Immunology of Hodgkin's disease.  

PubMed

Hodgkin's disease is characterized by an immune response in the involved tissues that is predominantly CD4 mediated. The CD4+ T-cells are CD45RO+ and CD45RBdim, they express several activation markers but lack CD26, and in vitro can be stimulated to produce gamma-interferon and IL-4, but not IL-2. This is not the usual immunophenotype and cytokine production pattern of Th1, Th2 or Th0 cells and may be a reflection of anergy. The cause of such an anergic reaction is not clear since RS cells express HLA class II as well as the co-stimulator molecules CD80 and CD86. It is possible that a (hypothetical) super antigen expressed on the RS cells may play a role. The absence of IL-2 production however explains the absence of a CD8 mediated response. In addition to that, RS cells generally do not express HLA class I, which allows them to escape CD8 mediated responses. The link between the ineffective immune response in the tissue and the generalized immune deficiency in Hodgkin's disease may consist of several components. These include the influx of mature T-cells into the affected tissues, the secretion of inhibitory molecules by the neoplastic cells and the spill-over of the anergic T-cell response into the general circulation by either the Hodgkin related antigen or also as a result of an IL-4 dominated response. The latter possibility may also be related to the hyper-gamma-globulinaemia and the frequently observed high IgE levels. PMID:8922239

Poppema, S

1996-09-01

67

A malignant lymphoma with histological features and immunophenotypic profile intermediate between EBV-positive diffuse large B-cell lymphoma and EBV-positive classical Hodgkin lymphoma in a 67-year-old female: a "gray zone" lymphoma associated with Epstein-Barr virus in the elderly.  

PubMed

Epstein-Barr virus (EBV) can be associated with both classical Hodgkin lymphoma (cHL) and non-Hodgkin lymphoma of the B-cell type, particularly in immunodeficient patients or elderly individuals. While polymorphic variants of EBV-positive large B-cell lymphoma (EBV+ DLBCL) frequently resemble cHL in morphology, and thereby may cause diagnostic difficulty, a true gray zone lymphoma with overlapping morphological and immunophenotypical features of EBV+ DLBCL and EBV+ cHL has not been reported in the literature. We describe a unique case of an EBV+ malignant lymphoma of B-cell origin with hybrid features of EBV+ DLBCL and EBV+ cHL in a 67-year-old female without an identifiable etiology for immunodeficiency. The biopsy of an enlarged lymph node showed a polymorphic infiltrate containing Reed-Sternberg-like pleomorphic large cells, which were positive for CD30 and CD15. Although CD20 was negative and PAX5 and CD45 were down-regulated, the pleomorphic large cells expressed multiple other B-cell antigens which are characteristically absent in cHL. EBV-encoded RNA hybridization (EBER) studies demonstrated nuclear reactivity in the large cells as well as in the smaller bystander cells. A clonal rearrangement of the immunoglobulin heavy chain gene was also detected by PCR. Although the results of the EBV and genotypic studies suggest this case may be an example of EBV+ DLBCL of the elderly instead of EBV+ cHL, the immunophenotype is strikingly ambiguous. Thus, this case may represent an interface between EBV+ DLBCL and EBV+ cHL. PMID:22572037

Wang, Endi; Papavassiliou, Paulie; Sebastian, Siby

2012-06-15

68

Nodular lymphocyte-predominant Hodgkin lymphoma of the tonsil: a case study using immunohistochemistry and FISH analysis and review of the literature  

Microsoft Academic Search

Nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma that differs from classic Hodgkin\\u000a lymphoma with respect to histological and clinical presentations. This type of lymphoma typically affects predictable lymph\\u000a node groups with excellent treatment outcomes. However, rare atypical locations have also been described and a possible diverse\\u000a clinical or biological subtype has been suggested. We present

Maria G. Ioannou; Evangelos Kouvaras; Eleftheria Gletsou; Constantina Papacharalambous; Panagiota Matsouka; George K. Koukoulis; Jon D van der Walt

69

Gemcitabine and Bendamustine in Patients With Relapsed or Refractory Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2014-08-08

70

A Phase II Trial of Panobinostat and Lenalidomide in Patients With Relapsed or Refractory Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma

2013-07-15

71

Combination Chemotherapy Followed by Radiation Therapy in Treating Young Patients With Newly Diagnosed Hodgkin's Lymphoma  

ClinicalTrials.gov

Childhood Favorable Prognosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma

2013-10-24

72

Brentuximab Vedotin and Combination Chemotherapy in Treating Older Patients With Previously Untreated Stage II-IV Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma

2015-03-10

73

Clinical and Pathologic Studies in Non-Hodgkin's Lymphoma Patients Receiving Antibody Treatment  

ClinicalTrials.gov

Lymphoma, Non-Hodgkin; Lymphomas: Non-Hodgkin; Lymphomas: Non-Hodgkin Cutaneous Lymphoma; Lymphomas: Non-Hodgkin Diffuse Large B-Cell; Lymphomas: Non-Hodgkin Follicular / Indolent B-Cell; Lymphomas: Non-Hodgkin Mantle Cell; Lymphomas: Non-Hodgkin Marginal Zone; Lymphomas: Non-Hodgkin Peripheral T-Cell; Lymphomas: Non-Hodgkin Waldenstr Macroglobulinemia

2011-05-31

74

Peripheral T Cell Non-Hodgkin's Lymphoma following Treatment of Hodgkin's Lymphoma  

PubMed Central

Previous reports have suggested that non-Hodgkin's lymphoma (NHL) is more likely to develop in patients with Hodgkin lymphoma (HL) compared to the general population. These two can occur synchronously or metachronously. We report here on a case of nodular sclerosis classical HL and T cell NHL that occurred in a patient metachronously. Peripheral T cell lymphoma (PTCL) of the patient was found about 2 years after treatment of classical HL. When the patient was diagnosed with HL, biopsy revealed typical RS cells, presenting positive for CD30 and CD15 and negative for CD79a and CD3 in immunohistochemistry. And PCR analysis showed IgH gene rearrangement; however, T cell receptor gene rearrangement and Epstein-Barr virus (EBV) were not detected on PCR analysis. After 2 years of treatment of HL, colonoscopic biopsy and lymph node biopsy showed CD3 positive atypical cells intermixed with small reactive lymphoid cells and plasma cells, indicating T cell lymphoma. PCR analysis demonstrated T cell receptor gene rearrangement and did not detect EBV. Although it is rare, synchronous or metachronous HL and NHL may occur. Therefore, we may need to ensure pathological confirmation, especially in case of lymphoma that did not respond to chemotherapy. PMID:25664194

Chang, Sun Hee; Lee, Hye Ran

2015-01-01

75

Focusing on the Classical or Contemporary? Chinese Science Teacher Educators' Conceptions of Nature of Science Content to Be Taught to Pre-Service Science Teachers  

ERIC Educational Resources Information Center

Drawing from the phenomenographic perspective, an exploratory study investigated Chinese teacher educators' conceptions of teaching Nature of Science (NOS) to pre-service science teachers through semi-structured interviews. Five key dimensions emerged from the data. This paper focuses on the dimension, "NOS content to be taught to…

Wan, Zhi Hong; Wong, Siu Ling; Wei, Bing; Zhan, Ying

2013-01-01

76

Curcuma Contra Cancer? Curcumin and Hodgkin’s Lymphoma  

PubMed Central

Curcumin, a phytochemical isolated from curcuma plants which are used as coloring ingredient for the preparation of curry powder, has several activities which suggest that it might be an interesting drug for the treatment or prevention of cancer. Curcumin targets different pathways which are involved in the malignant phenotype of tumor cells, including the nuclear factor kappa B (NFKB) pathway. This pathway is deregulated in multiple tumor entities, including Hodgkin’s lymphoma (HL). Indeed, curcumin can inhibit growth of HL cell lines and increases the sensitivity of these cells for cisplatin. In this review we summarize curcumin activities with special focus on possible activities against HL cells. PMID:24665206

Kewitz, Stefanie; Volkmer, Ines; Staege, Martin S.

2013-01-01

77

Brentuximab vedotin for relapsed or refractory Hodgkin’s lymphoma  

PubMed Central

Brentuximab vedotin is a promising antibody–drug conjugate (ADC) targeting CD30 of tumor cells. It selectively delivers monomethyl auristatin E (MMAE) into CD30-expressing cells and induces tumor cell apoptosis. Various clinical trials have provided evidence that it is effective in relapsed or refractory Hodgkin’s lymphoma (HL), and it has also shown its advantages in other CD30-positive lymphomas. In this review, we focus on the structure, mechanisms, and pharmacokinetics of brentuximab vedotin. We also summarize clinical trials with brentuximab vedotin and make recommendations for brentuximab vedotin in the treatment of relapsed or refractory HL.

Chen, Runzhe; Chen, Baoan

2015-01-01

78

Drugs Approved for Hodgkin Lymphoma  

Cancer.gov

This page lists cancer drugs approved by the Food and Drug Administration (FDA) for Hodgkin lymphoma. The list includes generic names, brand names, and common drug combinations, which are shown in capital letters. The drug names link to NCI's Cancer Drug Information summaries.

79

Traditional Chinese medicine  

Microsoft Academic Search

The classical Chinese pharmacopoeia describes a large number of herbal formulations that are used for the treatment of a wide variety of diseases. This therapeutic approach is ignored by many and considered to be an alternative to conventional medicine by others. The scientific proof and clinical validation of these herbal formulations require a rigorous approach that includes chemical standardization, biological

Robert Yuan; Yuan Lin

2000-01-01

80

Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin's lymphoma: the  

E-print Network

1 Family history of cancer in children with acute leukemia, Hodgkin's lymphoma or non-Hodgkin history, cancer, children, acute leukemia, Hodgkin's lymphoma, non- Hodgkin's lymphoma Abbreviations used: AL, acute leukemia; ALL, acute lymphoblastic leukemia; AML, acute myeloblastic leukemia; HL, Hodgkin

Paris-Sud XI, Université de

81

What You Need to Know about Non-Hodgkin Lymphoma  

MedlinePLUS

... Español What You Need To Know About™ Non-Hodgkin Lymphoma This booklet is about non-Hodgkin lymphoma, a cancer that starts in the immune system. Non-Hodgkin lymphoma is also called NHL. PDF This booklet ...

82

What You Need to Know about Hodgkin Lymphoma  

MedlinePLUS

... Groups Español What You Need To Know About™ Hodgkin Lymphoma This booklet is about Hodgkin lymphoma. This type of cancer starts in the lymph system. Another name for this cancer is Hodgkin disease. Learning about medical care for your cancer ...

83

What Are the Key Statistics about Non-Hodgkin Lymphoma?  

MedlinePLUS

... for non-Hodgkin lymphoma? What are the key statistics about non-Hodgkin lymphoma? Non-Hodgkin lymphoma (NHL) ... Symptoms of Cancer Treatments & Side Effects Cancer Facts & Statistics News About Cancer Expert Voices Blog Programs & Services ...

84

Classic and Modern Meridian Studies: A Review of Low Hydraulic Resistance Channels along Meridians and Their Relevance for Therapeutic Effects in Traditional Chinese Medicine  

PubMed Central

Meridian theory is one of the core components of the theory of traditional Chinese medicine (TCM). It gives an integral explanation for how human life works, how a disease forms, and how a therapy acts to treat a disease. If we do not understand the meridians, it is hard to understand the TCM. People in China and abroad had been working hard for 50 years, trying to understand the meridians; then 15 years ago a breakthrough idea appeared when we realized that they are low resistance fluid channels where various chemical and physical transports take place. The channel is called low hydraulic resistance channel (LHRC) and the chemical transport is named volume transmission (VT). This review aims to give a full understanding of the essence of meridian and its works on the therapies of TCM.

Zhang, Wei-Bo; Wang, Guang-Jun; Fuxe, Kjell

2015-01-01

85

Bortezomib, Ifosfamide, and Vinorelbine Tartrate in Treating Young Patients With Hodgkin's Lymphoma That is Recurrent or Did Not Respond to Previous Therapy  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Childhood Lymphocyte Depletion Hodgkin Lymphoma; Childhood Lymphocyte Predominant Hodgkin Lymphoma; Childhood Mixed Cellularity Hodgkin Lymphoma; Childhood Nodular Lymphocyte Predominant Hodgkin Lymphoma; Childhood Nodular Sclerosis Hodgkin Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Childhood Hodgkin Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Childhood Hodgkin Lymphoma

2014-06-18

86

EXPONENTIAL TIME DIFFERENCING FOR HODGKIN-HUXLEY-LIKE ODES.  

PubMed

Several authors have proposed the use of exponential time differencing (ETD) for Hodgkin-Huxley-like partial and ordinary differential equations (PDEs and ODEs). For Hodgkin-Huxley-like PDEs, ETD is attractive because it can deal effectively with the stiffness issues that diffusion gives rise to. However, large neuronal networks are often simulated assuming "space-clamped" neurons, i.e., using the Hodgkin-Huxley ODEs, in which there are no diffusion terms. Our goal is to clarify whether ETD is a good idea even in that case. We present a numerical comparison of first- and second-order ETD with standard explicit time-stepping schemes (Euler's method, the midpoint method, and the classical fourth-order Runge-Kutta method). We find that in the standard schemes, the stable computation of the very rapid rising phase of the action potential often forces time steps of a small fraction of a millisecond. This can result in an expensive calculation yielding greater overall accuracy than needed. Although it is tempting at first to try to address this issue with adaptive or fully implicit time-stepping, we argue that neither is effective here. The main advantage of ETD for Hodgkin-Huxley-like systems of ODEs is that it allows underresolution of the rising phase of the action potential without causing instability, using time steps on the order of one millisecond. When high quantitative accuracy is not necessary and perhaps, because of modeling inaccuracies, not even useful, ETD allows much faster simulations than standard explicit time-stepping schemes. The second-order ETD scheme is found to be substantially more accurate than the first-order one even for large values of ?t. PMID:24058276

Börgers, Christoph; Nectow, Alexander R

2013-01-01

87

EXPONENTIAL TIME DIFFERENCING FOR HODGKIN–HUXLEY-LIKE ODES  

PubMed Central

Several authors have proposed the use of exponential time differencing (ETD) for Hodgkin–Huxley-like partial and ordinary differential equations (PDEs and ODEs). For Hodgkin–Huxley-like PDEs, ETD is attractive because it can deal effectively with the stiffness issues that diffusion gives rise to. However, large neuronal networks are often simulated assuming “space-clamped” neurons, i.e., using the Hodgkin–Huxley ODEs, in which there are no diffusion terms. Our goal is to clarify whether ETD is a good idea even in that case. We present a numerical comparison of first- and second-order ETD with standard explicit time-stepping schemes (Euler’s method, the midpoint method, and the classical fourth-order Runge–Kutta method). We find that in the standard schemes, the stable computation of the very rapid rising phase of the action potential often forces time steps of a small fraction of a millisecond. This can result in an expensive calculation yielding greater overall accuracy than needed. Although it is tempting at first to try to address this issue with adaptive or fully implicit time-stepping, we argue that neither is effective here. The main advantage of ETD for Hodgkin–Huxley-like systems of ODEs is that it allows underresolution of the rising phase of the action potential without causing instability, using time steps on the order of one millisecond. When high quantitative accuracy is not necessary and perhaps, because of modeling inaccuracies, not even useful, ETD allows much faster simulations than standard explicit time-stepping schemes. The second-order ETD scheme is found to be substantially more accurate than the first-order one even for large values of ?t. PMID:24058276

Börgers, Christoph; Nectow, Alexander R.

2013-01-01

88

Simultaneous presentation of relapsing Hodgkin's disease and treatment-related non-Hodgkin's lymphoma  

SciTech Connect

A 55-year-old white man was diagnosed in 1975 with Hodgkin's disease stage IIA, mixed cellularity. He was treated with 4,500 rads to an inverted-Y field followed by six cycles of MOPP and remained in complete remission. In 1983 a right axillary lymph node biopsy showed recurrent Hodgkin's disease, mixed cellularity. While receiving his initial chemotherapy he developed persistent epigastric distress. Endoscopic gastric biopsy demonstrated a diffuse large-cell non-Hodgkin's lymphoma. Surface marker studies confirmed the separate identity of these two malignant lymphoproliferative processes. This represents the first reported simultaneous occurrence of relapsing Hodgkin's disease with treatment-related non-Hodgkin's lymphoma.

Perri, R.T.; Allen, J.I.; Oken, M.M.; Limas, C.; Kay, N.E.

1985-01-01

89

Constitutive overexpression of a novel 21 kDa protein by Hodgkin Lymphoma and Aggressive Non-Hodgkin Lymphomas  

PubMed Central

Background CD30, a 120 kDa surface phosphorylated protein is a member of tumour necrosis/nerve growth factor receptor (TNF/NGFR) family and constitutively expressed by Hodgkin and Reed-Sternberg (HRS) cells of Hodgkin lymphoma (HL) and the neoplastic cells of Anaplastic Large Cell Lymphoma (ALCL). A disease-specific protein marker is yet to be identified in Hodgkin lymphoma cells. In order to define HL-specific biomarkers, novel murine monoclonal antibodies were developed in our laboratory. Results Murine monoclonal antibodies (mabs) were raised against the B3 sub clone of HL-derived cell line KM-H2. Two of these mabs (clone R23.1 mab and clone R24.1 mab) are IgG1 class antibodies that recognize a 21 kDa protein present at the cell membrane and in the cytoplasm in HL-derived cell lines. Clone R24.1 mab recognizes a formalin-resistant epitope and labels HRS cells in tissue samples from patients with HL of the classical type, ALCL, and subsets of T and B cell aggressive Non-Hodgkin Lymphomas (NHL). The antigen recognized by the clone R23.1 mab and clone R24.1 mab does not share epitopes with CD30 cluster regions A, B, or C, and, unlike CD30, is not expressed by phytohemagglutinin (PHA) activated T cells. Conclusion The 21 kDa protein detected by clone R23.1 and clone R24.1 mabs is a novel membrane-associated protein that may be a potential marker for the diagnosis and targeted therapy of HL and aggressive T and B cell NHL. PMID:18218123

Zhou, Minglong; Fadlelmola, Faisal M; Cohn, Jason B; Skinnider, Brian; Gascoyne, Randy D; Banerjee, Diponkar

2008-01-01

90

Nonlinear observer design and synchronization analysis for classical models of neural oscillators  

E-print Network

This thesis explores four nonlinear classical models of neural oscillators, the Hodgkin- Huxley model, the Fitzhugh-Nagumo model, the Morris-Lecar model, and the Hindmarsh-Rose model. Analysis techniques for nonlinear ...

Bharath, Ranjeetha

2013-01-01

91

Epidemiology of EBV and Hodgkin's lymphoma  

Microsoft Academic Search

Summary The incidence of Hodgkin's disease shows marked hetero- geneity with respect to age, gender, race, geographical locale, social class and histological subtype. The Epstein-Barr virus (EBV) is associated with a proportion of cases, approxi- mately 40% in developed countries, and there is a body of evidence which suggests that mixed cellularity Hodgkin's dis- ease is more likely to be

A. F. Jarrett; A. A. Armstrong; E. Alexander

92

The Pathology and Nomenclature of Hodgkin's Disease  

Microsoft Academic Search

Summary The diverse morphologic expressions of Hodgkin's disease have been reviewed and compared to the numerous histologie terms in the literature and the author's recently proposed histologie types. The relationship of the histologie findings to the clinical stages and survival has also been analyzed. The histologie ex pressions of the Hodgkin's disease process appear to be reparable into the following

ROBERT J. LUKES; JAMES J. BUTLER

93

Unusual primary osseous Hodgkin’s lymphoma: A case report  

PubMed Central

Hodgkin’s lymphoma (HL) is one of the few adult malignancies that most frequently presents with a progressive, painless enlargement of the peripheral lymph nodes. A primary osseous presentation of HL, without lymph node involvement, is extremely rare. The present study describes a case of primary multifocal osseous HL in a 22-year-old female. The patient presented with pain in the lumbar-sacral-pelvic area and a prolonged fever. Pathological examination led to a diagnosis of primary multifocal osseous lymphoma, and the patient was subsequently prescribed a course of Adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy. Following this, the patient recovered with no pain or fever, and computed tomography identified no further progression. The clinical, radiological and histological features of HL are similar to those of other medical conditions, such as tuberculosis and eosinophilic granuloma. Furthermore, in rare cases, HL may even occur in combination with multiple myeloma. This makes it difficult to diagnose the condition, which often leads to a delay in treatment. Clinicians should not ignore HL when it manifests in the unusual primary osseous form. PMID:25621037

LUO, WEI; ZHANG, FANGJIE; SUN, JINPENG; HE, HONGBO

2015-01-01

94

Geniposide, the component of the Chinese herbal formula Tongluojiunao, protects amyloid-? peptide (1–42-mediated death of hippocampal neurons via the non-classical estrogen signaling pathway  

PubMed Central

Tongluojiunao (TLJN) is an herbal medicine consisting of two main components, geniposide and ginsenoside Rg1. TLJN has been shown to protect primary cultured hippocampal neurons. However, its mechanism of action remains unclear. In the present study, primary cultured hippocampal neurons treated with A?1–42 (10 µmol/L) significantly increased the release of lactate dehydrogenase, which was markedly reduced by TLJN (2 µL/mL), specifically by the component geniposide (26 µmol/L), but not ginsenoside Rg1 (2.5 µmol/L). The estrogen receptor inhibitor, ICI182780 (1 µmol/L), did not block TLJN- or geniposide-mediated decrease of lactate dehydrogenase under A?1–42-exposed conditions. However, the phosphatidyl inositol 3-kinase or mitogen-activated protein kinase pathway inhibitor, LY294002 (50 µmol/L) or U0126 (10 µmol/L), respectively blocked the decrease of lactate dehydrogenase mediated by TLJN or geniposide. Therefore, these results suggest that the non-classical estrogen pathway (i.e., phosphatidyl inositol 3-kinase or mitogen-activated protein kinase) is involved in the neuroprotective effect of TLJN, specifically its component, geniposide, against A?1–42-mediated cell death in primary cultured hippocampal neurons. PMID:25206841

Li, Jiao; Wang, Feng; Ding, Haimin; Jin, Chunyan; Chen, Jinyan; Zhao, Yanan; Li, Xiaojing; Chen, Wenju; Sun, Ping; Tan, Yan; Zhang, Qi; Wang, Xu; Fan, Angran; Hua, Qian

2014-01-01

95

Studies on traditional Chinese poetry style identification  

Microsoft Academic Search

Based on a machine learning method, Naive Bayes, this paper proposes a traditional Chinese poetry style identification calculation model to distinguish bold-and-unrestrained or graceful-and-restrained styles, which derives from machine learning Chinese classical Ci in song dynasty and has achieved satisfactory identification results in application.

Yong Yi; Zhong-Shi He; Liang-Yan Li; Tian Yu

2004-01-01

96

Hodgkin’s Disease after Splenic Immunocytoma: Rare Manifestation of a Dual Lymphoma  

Microsoft Academic Search

Summary Background: Communications concerning Hodgkin’s disease (HD) after non-Hodgkin’s lymphoma (NHL) are rather rare, whereas NHL after HD represents a common form of dual lymphoma. Patient: A 68-year-old woman developed nodular sclerosing HD of the upper mediastinum and right supracla-vicular fossa stage ?B 2 years after splenectomy for a splenic lymphoplasmocytoid immunocytoma. She died of septic infection after 2 cycles

K. Ranft; H. Renter

1996-01-01

97

Hodgkin’s Lymphoma in Older Patients: an Orphan Disease?  

PubMed Central

Hodgkin Lymphoma HL can be cured in the large majority of younger patients, but prognosis for older patients, especially those with advanced-stage disease, has not improved substantially. The percentage of HL patients aged over 60 ranges between 15% and 35%. A minority of them is enrolled into clinical trials. HL in the elderly have some specificities: more frequent male sex, B-symptoms, advanced stage, sub diaphragmatic presentation, higher percentage of mixed cellularity, up to 50% of advanced cases associated to EBV. Very old age (>70) and comorbidities are factor of further worsening prognosis. Like in younger patients, ABVD is the most used protocol, but treatment outcome remains much inferior with more frequent, severe and sometimes specific toxicities. Few prospective studies with specific protocols are available. The main data have been published by the Italian Lymphoma Group with the VEPEMB schedule and the German Hodgkin Study Group with the PVAG regimen. Recently, the Scotland and Newcastle Lymphoma Study Group published the SHIELD program associating a prospective phase 2 trial with VEPEMB and a prospective registration of others patients. Patients over 60y with early-stage disease received three cycles plus radiotherapy and had 81% of 3-year overall survival (OS). Those with advanced-stage disease received six cycles, with 3-year OS of 66%. The role of geriatric and comorbidity assessment in the treatment’s choice for HL in the elderly is a major challenge. The combination of loss of activities of daily living combined with the age stratification more or less 70y has been shown as a simple and effective survival model. Hopes come from promising new agents like brentuximab-vedotin (BV) a novel antibody-drug conjugate. The use of TEP to adapt the combination of chemotherapy and radiotherapy according to the metabolic response could also be way for prospective studies. PMID:25045458

Thyss, Antoine; Saada, Esma; Gastaud, Lauris; Peyrade, Frédéric; Re, Daniel

2014-01-01

98

Hypotension Associated with Advanced Hodgkin Lymphoma  

PubMed Central

Hypotension is an extremely rare manifestation of Hodgkin lymphoma. We report the case of a patient who presented with new onset hypotension and was diagnosed with urosepsis and septic shock requiring pressor support for maintaining his blood pressure. computed tomography (CT) scan of abdomen showed liver lesions, which were new on comparison with a CT abdomen done 3 weeks back. Biopsy of the liver lesions and subsequently a bone marrow biopsy showed large atypical Reed-Sternberg cells, positive for CD15 and CD 30 and negative for CD45, CD3 and CD20 on immuno-histochemical staining, hence establishing the diagnosis of Hodgkin lymphoma. The mechanism involved in Hodgkin lymphoma causing hypotension remains anecdotal, but since it is mostly seen in patients with advanced Hodgkin lymphoma, it is hypothetically related to a complex interaction between cytokines and mediators of vasodilatation. Here we review relevant literature pertaining to presentation and pathogenesis of this elusive and rare association. PMID:25317321

Dang, Geetanjali; Hamad, Hussein; Mohajer, Roozbeh; Catchatourian, Rosalind; Kovarik, Paula

2014-01-01

99

Automated Image Analysis of Hodgkin lymphoma  

E-print Network

Hodgkin lymphoma is an unusual type of lymphoma, arising from malignant B-cells. Morphological and immunohistochemical features of malignant cells and their distribution differ from other cancer types. Based on systematic tissue image analysis, computer-aided exploration can provide new insights into Hodgkin lymphoma pathology. In this paper, we report results from an image analysis of CD30 immunostained Hodgkin lymphoma tissue section images. To the best of our knowledge, this is the first systematic application of image analysis to a set of tissue sections of Hodgkin lymphoma. We have implemented an automatic procedure to handle and explore image data in Aperio's SVS format. We use pre-processing approaches on a down-scaled image to separate the image objects from the background. Then, we apply a supervised classification method to assign pixels to predefined classes. Our pre-processing method is able to separate the tissue content of images from the image background. We analyzed three immunohistologically ...

Schmitz, Alexander; Schäfer, Hendrik; Döring, Claudia; Ackermann, Jörg; Dichter, Norbert; Hartmann, Sylvia; Hansmann, Martin-Leo; Koch, Ina

2012-01-01

100

General Information about Childhood Hodgkin Lymphoma  

MedlinePLUS

... system. Signs of childhood Hodgkin lymphoma include swollen lymph nodes, fever, night sweats, and weight loss. These and ... child has any of the following: Painless, swollen lymph nodes in the neck, chest, underarm, or groin . Fever ...

101

General Information about Adult Hodgkin Lymphoma  

MedlinePLUS

... lymphoma. Signs of adult Hodgkin lymphoma include swollen lymph nodes, fever, night sweats, and weight loss. These and ... skin. Feeling very tired. Tests that examine the lymph nodes are used to detect (find) and diagnose adult ...

102

Treatment Options for Non-Hodgkin Lymphoma  

MedlinePLUS

... trials is available from the NCI Web site . Aggressive, Stage I and Contiguous Stage II Adult Non- ... trials is available from the NCI Web site . Aggressive, Noncontiguous Stage II/III/IV Adult Non-Hodgkin ...

103

Population Encoding With Hodgkin-Huxley Neurons.  

PubMed

The recovery of (weak) stimuli encoded with a population of Hodgkin-Huxley neurons is investigated. In the absence of a stimulus, the Hodgkin-Huxley neurons are assumed to be tonically spiking. The methodology employed calls for 1) finding an input-output (I/O) equivalent description of the Hodgkin-Huxley neuron and 2) devising a recovery algorithm for stimuli encoded with the I/O equivalent neuron(s). A Hodgkin-Huxley neuron with multiplicative coupling is I/O equivalent with an Integrate-and-Fire neuron with a variable threshold sequence. For bandlimited stimuli a perfect recovery of the stimulus can be achieved provided that a Nyquist-type rate condition is satisfied. A Hodgkin-Huxley neuron with additive coupling and deterministic conductances is first-order I/O equivalent with a Project-Integrate-and-Fire neuron that integrates a projection of the stimulus on the phase response curve. The stimulus recovery is formulated as a spline interpolation problem in the space of finite length bounded energy signals. A Hodgkin-Huxley neuron with additive coupling and stochastic conductances is shown to be first-order I/O equivalent with a Project-Integrate-and-Fire neuron with random thresholds. For stimuli modeled as elements of Sobolev spaces the reconstruction algorithm minimizes a regularized quadratic optimality criterion. Finally, all previous recovery results of stimuli encoded with Hodgkin-Huxley neurons with multiplicative and additive coupling, and deterministic and stochastic conductances are extended to stimuli encoded with a population of Hodgkin-Huxley neurons. PMID:24194625

Lazar, Aurel A

2010-02-01

104

Chinese Cooking.  

ERIC Educational Resources Information Center

This unit, intended for secondary level students, is a general introduction to Chinese cooking. It is meant to inform students about the origins of Chinese cooking styles in their various regional manifestations, and it can be used to discuss how and why different cultures develop different styles of cooking. The first part of the unit, adapted…

Kane, Tony

105

[Asplenia in the Hodgkin's patient].  

PubMed

FEWER INDICATIONS AFTER SPLENECTOMY: Real therapeutic progress has been achieved over the last fifty years for patients with Hodgkin's disease known for their chronic immunodepression. Since the advent of effective chemotherapy protocols such as ABVD, and more recently intensive chemotherapy completed as needed with an autograft, splenectomy is no longer performed for therapeutic purposes but may be indicated for its contribution to diagnosis. STRATIFICATION OF RISK OF ASPLENISM: There remain however several questions concerning the infectious complications in these patients given chemotherapy and splenic radiotherapy. One of the objectives of this work was to propose a stratification of risk of asplenism as a function of treatments administered, the level of initial immunodepression, and the age of the patient. PMID:14631638

Gardembas-Pain, M; Mege, M; Pabot du Chatelard, P

2003-09-01

106

Differentiation between sarcoidosis and Hodgkin’s lymphoma based on mediastinal lymph node involvement pattern: Evaluation using spiral CT scan  

PubMed Central

Summary Background: The purpose of this study was to determine the specific and detailed anatomic sites and morphologic characteristics of mediastinal lymph nodes on spiral computed tomography for the purpose of differentiation between sarcoidosis and Hodgkin’s lymphoma. Material/Methods: Anatomical distribution of mediastinal lymph nodes on spiral CT was reviewed in 39 patients with sarcoidosis and 37 patients with Hodgkin’s lymphoma using the International Association for the Study of Lung Cancer (IASLC) lymph node map. Other morphologic features such as lymph node calcification or coalescence of adjacent lymph nodes were also compared. Results: Zone 10 was involved more often in sarcoidosis than in Hodgkin’s lymphoma. On the other hand, there was a higher tendency for presence of zone 1 and 3 as well as retrocrural and internal mammary lymphadenopathy in Hodgkin’s lymphoma than in sarcoidosis. Sarcoidosis presented with intranodal calcifications more often than Hodgkin’s lymphoma. Coalescence, pressure effect on adjacent structures and central cavitations were significantly more common in Hodgkin’s lymphoma. Conclusions: Findings of the present study indicate that specific anatomical distribution and morphological patterns of mediastinal lymph nodes, as demonstrated on spiral CT, can be useful in differentiating sarcoidosis from Hodgkin’s lymphoma. PMID:24115955

Mehrian, Payam; Ebrahimzadeh, Seyed Amir

2013-01-01

107

Classical Conditioning  

NSDL National Science Digital Library

!!Classical Conditioning!! Classical conditioning is the use of Pavlovian conditioning procedures where a neutral stimulus becomes capable of evoking a response through pairing with an unconditioned stimulus. Click the link below to get an introduction into classical conditioning. Introduction to Classical Conditioning Now that you\\'ve been introduced to classical conditioning, view the clip at the link below, ...

Mrs. Palacios, Miss Miller, Mr. Rowser

2008-04-01

108

Memristor, Hodgkin-Huxley, and edge of chaos.  

PubMed

From a pedagogical point of view, the memristor is defined in this tutorial as any 2-terminal device obeying a state-dependent Ohm's law. This tutorial also shows that from an experimental point of view, the memristor can be defined as any 2-terminal device that exhibits the fingerprints of 'pinched' hysteresis loops in the v-i plane. It also shows that memristors endowed with a continuum of equilibrium states can be used as non-volatile analog memories. This tutorial shows that memristors span a much broader vista of complex phenomena and potential applications in many fields, including neurobiology. In particular, this tutorial presents toy memristors that can mimic the classic habituation and LTP learning phenomena. It also shows that sodium and potassium ion-channel memristors are the key to generating the action potential in the Hodgkin-Huxley equations, and that they are the key to resolving several unresolved anomalies associated with the Hodgkin-Huxley equations. This tutorial ends with an amazing new result derived from the new principle of local activity, which uncovers a minuscule life-enabling 'Goldilocks zone', dubbed the edge of chaos, where complex phenomena, including creativity and intelligence, may emerge. From an information processing perspective, this tutorial shows that synapses are locally-passive memristors, and that neurons are made of locally-active memristors. PMID:23999613

Chua, Leon

2013-09-27

109

Radiation-induced splenic atrophy in patients with Hodgkin's disease and non-Hodgkin's lymphomas  

Microsoft Academic Search

Effective treatment of Hodgkin's disease requires the determination of the extent of the disease. This usually involves staging laparotomy, which includes splenectomy and biopsies of the para-aortic lymph nodes, liver, and bone marrow. Absence of the spleen predisposes a person to fulminant septicemia from encapsulated bacteria, a risk even greater in patients undergoing treatment for Hodgkin's disease. For this reason,

Morris O. Dailey; C. Norman Coleman; Henry S. Kaplan

1980-01-01

110

Radiation-induced splenic atrophy in patients with Hodgkin's disease and non-Hodgkin's lymphomas  

SciTech Connect

Effective treatment of Hodgkin's disease requires the determination of the extent of the disease. This usually involves staging laparotomy, which includes splenectomy and biopsies of the para-aortic lymph nodes, liver, and bone marrow. Absence of the spleen predisposes a person to fulminant septicemia from encapsulated bacteria, a risk even greater in patients undergoing treatment for Hodgkin's disease. For this reason, some investigators have suggested that spleens not be removed for diagnosis but, rather, that they be included within the fields of radiation, which would preserve normal splenic function. We present a case of fatal spontaneous pneumococcal sepsis in a patient with splenic atrophy; the sepsis occurred 12 years after successful treatment of Hodgkin's disease by total nodal and splenic irradiation. A retrospective study of patients treated for Hodgkin's and non-Hodgkin's lymphomas indicated that atrophy and functional asplenia may be an important sequela of splenic irradiation.

Dailey, M.O.; Coleman, C.N.; Kaplan, H.S.

1980-01-24

111

Decomposing the Dynamics of Delayed Hodgkin-Huxley Neurons  

E-print Network

Decomposing the Dynamics of Delayed Hodgkin-Huxley Neurons G´abor Orosz Abstract. The effects is investigated using Floquet theory. These methods are applied to a system of delay coupled Hodgkin Introduction Since Hodgkin and Huxley has constructed the first biophysical model of a neuron more than six

Daly, Samantha

112

Modelling Neuronal Excitation: The Hodgkin-Huxley Model  

E-print Network

Modelling Neuronal Excitation: The Hodgkin-Huxley Model Thierry Mondeel July 13, 2012 #12;Contents.6 The Hodgkin-Huxley gate model 16 2.6.1 Persistent conductance . . . . . . . . . . . . . . . . . . 17 2.6.2 Transient conductance . . . . . . . . . . . . . . . . . . 18 3 The Hodgkin-Huxley model 20 3.1 The work

Planqué, Bob

113

Entrainment and Chaos in the Hodgkin-Huxley Oscillator  

E-print Network

Entrainment and Chaos in the Hodgkin-Huxley Oscillator Kevin K. Lin http that the Hodgkin-Huxley neuron model, driven by a periodic impulse train, can exhibit entrainment, transient chaos, rigorous perturbation theory of kicked oscillators (Qiudong Wang & Lai-Sang Young). 2. Hodgkin

Lin, Kevin K.

114

The Hodgkin-Huxley Model: A Quick Historical Overview  

E-print Network

The Hodgkin-Huxley Model: A Quick Historical Overview Rob Kass Department of Statistics understanding of how action potentials work. The latter is the triumph of the Hodgkin-Huxley model. I have broken the basic argument into 6 historical steps, of which the Hodgkin-Huxley model is the last. Main

Murphy, Robert F.

115

Prognostic Factors in Hodgkin Lymphoma  

PubMed Central

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise. PMID:25045461

Cuccaro, Annarosa; Bartolomei, Francesca; Cupelli, Elisa; Galli, Eugenio; Giachelia, Manuela; Hohaus, Stefan

2014-01-01

116

Incidence and Characteristics of Childhood Hodgkin’s Lymphoma in Greece: A Nationwide Study (Greece)  

Microsoft Academic Search

Objectives To estimate the incidence and epidemiological profile of childhood (0–14 years) Hodgkin’s lymphoma in Greece derived by\\u000a the network of childhood Hematology–Oncology departments on the basis of all 95 newly diagnosed cases during a seven-year\\u000a period.\\u000a \\u000a Methods Seventy-one of these cases were individually age and gender matched to an equal number of controls.\\u000a \\u000a \\u000a \\u000a Results The incidence of childhood Hodgkin Lymphoma

E. Petridou; E. Andrie; N. Dessypris; S. K. Dikalioti; D. Trichopoulos

2006-01-01

117

Bilateral breast cancer after cured Hodgkin's disease  

SciTech Connect

Three patients developed bilateral breast cancer at 10 to 24 years after mantle irradiation for locally or systemically advanced Hodgkin's disease (HD). Four of the six cancers in the three patients were detected only by mammography. Pathologically, five of the cancers were intraductal carcinomas (four with an invasive component) with one being a lobular carcinoma. Five of the six lesions were Stage I pathologically without evidence of axillary nodal involvement. It is recommended that female patients with Hodgkin's disease who have received mantle irradiation as part of the therapy for their Hodgkin's disease and who are observed for 10 or more years after completion of mantle irradiation be considered at risk for the development of breast cancer. Such patients should be monitored appropriately by routine bilateral mammograms to increase the early detection of early stage lesions.

Anderson, N.; Lokich, J. (New England Baptist Hospital, Boston, MA (USA))

1990-01-15

118

Late complications of Hodgkin's disease management  

SciTech Connect

In the past several decades, Hodgkin's disease has been transformed from a uniformly fatal illness to one that can be treated with the expectation of long-term remission or cure in the majority of patients. Because patients now survive for long periods after curative intervention, various complications have been identified. The spectrum of complications following curative therapy is quite diverse and includes immunologic, cardiovascular, pulmonary, thyroid, and gonadal dysfunction. In addition, second malignant neoplasms in the form of acute leukemia as well as secondary solid tumors have now been documented to occur with increased frequency in patients cured of Hodgkin's disease. 80 references.

Young, R.C.; Bookman, M.A.; Longo, D.L. (Fox Chase Cancer Center, Philadelphia, PA (USA))

1990-01-01

119

Hydrocele following treatment for Hodgkin's disease  

SciTech Connect

Thirteen Hodgkin's disease patients developed hydrocele after treatment with radiotherapy (12 patients) or chemotherapy (one patient). An additional patient developed testicular swelling following radiotherapy and chemotherapy. Eleven of 13 patients were staged with laparotomy (nine initially, two at restaging) which included pelvic and aortic node biopsies prior to development of hydrocele. Five of the patients developed radiation-related pericarditis. These data suggest that staging and treatment of Hodgkin's disease may disrupt pelvic lymphatic flow and lead to hydrocele formation. The high incidence of treatment-related pericarditis may suggest unusual sensitivity to radiation in this group of patients.

Duffey, P.; Campbell, E.W.; Wiernik, P.H.

1982-07-15

120

New therapies in non-Hodgkin lymphoma.  

PubMed

Non-Hodgkin lymphomas are among the most prevalent hematologic malignancies. Although the addition of rituximab (R) to chemotherapy has made a big impact in the treatment of B cell lymphomas, most of them are not cured yet. The panorama in natural killer/T cell lymphomas is more unsatisfactory, thus representing a group of diseases where effective therapies constitute an urgent medical need. In recent years, several new antineoplastic agents have been tested in clinical trials showing promising results. The aim of this review is to update information of these studies that are already changing the scenario of the treatment of patients with Non-Hodgkin lymphoma. PMID:25582186

Novelli, Silvana; Sierra, Jorge; Briones, Javier

2015-03-01

121

[Briefly analysis on academic origins of traditional Chinese medicine dispensing].  

PubMed

Through collecting and collating the development process of traditional Chinese medicine dispensing, the development of modern Chinese medicine dispensing on the basis of experience could be promoted. "Heyaofenji", "Hehe", " Heji" in ancient Chinese medicine, herbal medicine literature and law were collected, and then things were sorted out according to traditional Chinese medicine dispensing theory, skills and legal norms. Firstly, "Tang Ye Jing Fa" is the earliest book which marks the rudiment of traditional Chinese medicine dispensing. Secondly, traditional Chinese medicine dispensing theory formed in "Shen Nong's herbal classic". Thirdly, Zhang Zhongjing's "Treatise on Febrile Diseases" marked the formation of Chinese medicine dispensing skills. Lastly, Provisions in Tang Dynasty law marks the development of traditional Chinese medicine dispensing. PMID:25039195

Zhao, Xue-Min; Zhang, Xiao-Juan; Zhai, Hua-Qiang; Jin, Shi-Yuan

2014-04-01

122

T-cell non-Hodgkin's lymphoma after radiotherapy and chemotherapy for Hodgkin's disease  

SciTech Connect

A rapidly fatal T-cell lymphoma developed in a 25-year-old man who, over a period of seven years, had been treated with radiotherapy and combination chemotherapy for Hodgkin's disease (HD). Non-Hodgkin's lymphoma (NHL) is increasingly being recognized as a late sequel of therapy for HD, but this is the first case in which NHL of T-cell type has been identified in such circumstances.

Lowenthal, R.M.; Harlow, R.W.H.; Mead, A.E.; Tuck, D.; Challis, D.R.

1981-10-01

123

Adoptive T-Cell Therapy for Epstein-Barr Virus-Positive Hodgkin’s Disease  

Microsoft Academic Search

Immunotherapy approaches with antigen-specific cytotoxic T lymphocytes (CTLs) have proved safe and effective prophylaxis and treatment of Epstein-Barr virus (EBV)-associated lymphomas arising after bone marrow transplantation. EBV is also associated with other malignancies including about 40% of cases of Hodgkin’s disease making this tumor another potential target for EBV-targeted immunotherapy. While studies with autologous EBV-specific CTLs have shown antiviral activity

M. Helen Huls; Cliona M. Rooney; Helen E. Heslop

2003-01-01

124

Potential benefits of therapeutic splenectomy for patients with Hodgkin's disease and non-Hodgkin's lymphomas  

SciTech Connect

Thirty-four patients with Hodgkin's disease and non-Hodgkin's lymphoma underwent therapeutic splenectomies to improve hematologic tolerance for chemotherapy. The mean age was 40 years; there were 16 males and 18 females. Fourteen had Hodgkin's disease, 19 had non-Hodgkin's lymphoma, and 1 had malignant histocytosis. Nineteen had palpable splenomegaly, 19 had marrow involvement and 20 had splenic involvement by lymphoma. The following data were analyzed before and after splenectomy: mean white blood cell count (WBC) and platelet count on planned first day of cycle, delay ratio of chemotherapy delivery and percent maximal dose rate. Thirteen patients had non-Hodgkin's lymphoma, splenomegaly and positive bone marrow and showed significant benefit in all of the aforementioned parameters. Of the patients with prior irradiation, only those who completed their radiation greater than six months prior to splenectomy showed benefit. Ten patients had Hodgkin's disease, negative bone marrow and no splenomegaly. This group showed significant improvement in mean platelet count but more limited benefit in delay ratio and percent maximal dose rate. Thus, selected patients with lymphoma who are experiencing delays in chemotherapy because of poor count tolerance may benefit from splenectomy.

Schreiber, D.P.; Jacobs, C.; Rosenberg, S.A.; Cox, R.S.; Hoppe, R.T.

1985-01-01

125

Perceptions and uses of Chinese medicine among the Chinese in Hong Kong.  

PubMed

The present paper was based on both qualitative observations and quantitative survey data. Major findings are as follows: (1) The sacred or magical-religious tradition of Chinese medicine is accepted by a relatively small portion (roughly one-fifth) of the ordinary Chinese people in urban Hong Kong, and is relatively more popular among women or less educated people. (2) Both the classical-professional and the local-empirical traditions of secular medicine are resorted to by many Chinese people (over one half) either for treating diseases or for strengthening their constitution. The acceptance of secular Chinese medicine does not vary significantly among different sex, age, education, or income groups. It should be noted that secular Chinese medicine is often used in addition to or in combination with modern Western medicine. (3) It appears that most people are more confident in the Chinese medical tradition than in Chinese-style practitioners in Hong Kong, and that people's confidence in secular Chinese medicine has been increasing in recent years. (4) There are reasons for the confidence in secular Chinese medicine. Chinese medicine is generally perceived to be better than or as good as Western, scientific medicine in some ways, such as for tonic care, for fewer side effects, for curing the cause (not symptoms) of diseases, and for treating certain diseases. Therefore, to ordinary Chinese people, Chinese and Western medicine may perform either equivalent or complementary functions. (5) As regards the process of seeking medical care, most people seem to follow the pattern of moving from self-medication, using Chinese and/or Western home remedies, to Western-style doctors, to Chinese-style practitioners, and finally to a Western medical hospital. Policy and theoretical implications of these findings are discussed. PMID:7449412

Lee, R P

1980-12-01

126

Management of non-Hodgkin's lymphomas  

Microsoft Academic Search

The non-Hodgkin's lymphomas (NHL) are a heterogenous group of disorders characterised by malignant proliferation of lymphoid cells. The cellular origin is relatively well established with subtypes corresponding to the various stages of lymphocyte differentiation. The term encompasses a hotchpotch of conditions with very different morphological appearance, behaviour and clinical outcome. NHL comprise 2.4% of all cancers, with incidence increasing with

P J Mounter; A L Lennard

1999-01-01

127

Chinese Connections  

ERIC Educational Resources Information Center

When L. Brooks Patterson, the executive of Oakland County, Michigan, publicly called for the county to become the first in America to teach Mandarin Chinese in every public school district, the Oxford Community Schools responded immediately. Over the past four years, the school district of 5,030 students in southeastern Michigan has elevated the…

Skilling, William C.

2012-01-01

128

Clinical characteristics of 26 patients with primary extranodal Hodgkin lymphoma  

PubMed Central

Background: Most Hodgkin lymphoma (HL) patients present with disease in nodal regions. However, in a small subset, disease develops extranodal sites primarily, such as lung and liver. This study aims to identify the characteristics and outcomes of patients with primary extranodal HL. Methods: A retrospective analysis of patients with HL from 1998 to 2012 was enrolled. We selected 26 HL patients with primary extranodal involvement from 251 previously untreated HL patients. All data analyses were performed with SPSS software version 17.0 and GraphPad Prism 5. Results: We identified 26 patients with primary extranodal HL. Results in the series of young patients, male predominated. Pathologically, the major pathologic types were nodular sclerosis classical HL (NSCHL, 46.2%) and mixed cellularity classical HL (MCCHL, 38.5%). Thirteen patients had early stage (I or II stage). The most commonly primarily extranodal sites were the lung and the stomach and intestine, followed by the liver and bones. Fifteen of 26 received chemotherapy alone and 11 received combination therapy. Finally, primary extranodal HLs in our study have a favorable survival. Furthermore, there was no significant association between the international prognostic score (IPS) and survival in patients with extranodal HL. Conclusion: Our retrospective data in part reflect clinical characteristics of primary extranodal HL in China, and form the basis for further concerning researches. PMID:25197377

Ma, Jing; Wang, Yafei; Zhao, Haifeng; Liu, Su; li, Qian; Lin, Li; Yue, Yuanfang; Wang, Xiaofang; Zhao, Zhigang; Yu, Yong; Zhang, Yizhuo

2014-01-01

129

Computer Chinese Chess  

Microsoft Academic Search

This article describes the current state of computer Chinese chess (Xiang Qi). For two reasons, Chinese-chess programming is important in the field of Artificial Intelligence. First, Chinese chess is one of the most popular and oldest board games worldwide; currently the strength of a Chinese- chess program can be compared to that of human players. Second, the complexity of Chinese

Shi-jim Yen; Chang Chen; Tai-ning Yang; Shun-chin Hsu

2004-01-01

130

What Are the Risk Factors for Non-Hodgkin Lymphoma in Children?  

MedlinePLUS

... non-Hodgkin lymphoma in children? What are the risk factors for non-Hodgkin lymphoma in children? A ... causes non-Hodgkin lymphoma in children? ”) Other possible risk factors Some research has suggested that a family ...

131

Chinese Geography through Chinese Cuisine  

ERIC Educational Resources Information Center

China has the world's largest population, now over 1.3 billion, but its land area (much of it high mountains or desert) is about the same as that of the United States, which has less than one-fourth as many people. So Chinese farmers have learned to use every inch of their fertile land intensively. Pressure on the land has required extremely…

Lipman, Jonathan

2010-01-01

132

Chinese Dinosaurs  

NSDL National Science Digital Library

What's "Jurassic Park" in Mandarin? That isn't easy to say, but if you're interested in Chinese dinosaurs, then you will love the new online (and real) exhibit hosted by the Australian Museum in Sydney. A vast land containing many of the world's best-preserved dinosaur specimens, China offers remnants of many species not commonly available in Western exhibits. With lots to explore, the site features a readily accessible list of dinosaurs, each arranged under its Chinese-derived species name. Not like anything most of us have ever heard, many of the specimens look and seem familiar, at least as members of the dinosaur family. While generally well-executed, particularly worthy of note is the site's presentation of China's celebrated feathered dinosaurs, Caudipteryx zoui and Protarchaeopteryx, two curious figures believed to represent part of the great reptilian leap from land to air.

2002-01-01

133

Treatment Options for Primary Refractory/Recurrent Hodgkin Lymphoma in Children and Adolescents  

MedlinePLUS

... Search for Clinical Trials NCI Publications Español Childhood Hodgkin Lymphoma Treatment (PDQ®) Treatment Options for Primary Refractory/Recurrent Hodgkin Lymphoma in Children and Adolescents Treatment of primary ...

134

Classics Online.  

ERIC Educational Resources Information Center

Appraises several databases devoted to classical literature. Thesaurus Linguae Graecae (TLG) contains the entire extant corpus of ancient Greek literature, including works on lexicography and historiography, extending into the 15th century. Other works awaiting completion are the Database of Classical Bibliography and a CD-ROM pictorial dictionary…

Clayman, Dee L.

1995-01-01

135

Lymphocyte Depleted Hodgkin's Lymphoma Presented with Haemolytic Anemia: A Case Report and Literature Review.  

PubMed

Hodgkin's lymphoma accounts for ten per cent of all lymphomas. Lymphomas represent the third most frequent neoplasia on a worldwide scale and constitute 3 % of malignant tumors. In the United States, there are about 8,000 new cases every year. This case report describes a case of lymphocyte-depletion Hodgkin's lymphoma (LDHL) manifested by anemia. LDHL is the least common of the types of Hodgkin's disease, comprising less than 1 % of all cases of this cancer. A 19-year-old Indian male presented with complaint of huge asymptomatic swelling in the right lateral part of neck since 8 months. All the lymph nodes of the right side submandibular, submental, cervical and axillary lymph nodes were rubbery in consistency, tender and were palpable. The CBC revealed hemoglobin of 7.4 gm/dL and ESR count was highly raised up to 125 mm/first hour. Direct Coomb's test detected multiple antibodies IgG type, which was consistent with the diagnosis of Haemolytic anemia. Ultrasonography of the neck showed enlarged discrete lymph nodes on the right side of the neck. For further evaluation patient was subject for ultrasonography of the abdomen which revealed there was of enlargement of both spleen and liver. Lymph node FNAC revealed classic LDHL. Anemia and swelling resolved after completion of chemotherapy with adriamycin, bleomycin, vinblastine, and dacarbazine (ABVD) after 6 cycles. The literature review and our case report discuss the optimal management of this Hodgkin's lymphoma. To our knowledge, this is the first case of LDHL with Haemolytic Anemia treated with only ABVD regime. PMID:25861191

Singh, Ravinder; Sheikh, Soheyl; Pallagatti, Shambulingappa; Aggarwal, Amit; Gupta, Deepak; Handa, Roopika; Goyal, Gaurav; Kumar, Raman

2015-03-01

136

Primary cutaneous follicle center lymphoma with Hodgkin and Reed-Sternberg-like cells: a new histopathologic variant.  

PubMed

Primary cutaneous follicle center lymphoma (PCFCL) is the most frequent cutaneous B-cell lymphoma. A 62-year-old man presented with a solitary indolent subcutaneous nodule for 3 years duration, without other abnormalities. Histological examination showed lymphoproliferation with a nodular growth pattern characterized by fibrous collagen bands surrounding nodules. The nodules were composed of medium-sized centrocytes admixed with many large multilobulated and lacunar cells without eosinophils or granulomatous aspect. Hodgkin-like cells were CD30+, CD15+, PAX5+, OCT2+, BOB1+, MUM1+, Ki67+, Bcl6+ and focally CD20+ and EMA-, CD79a-, Bcl2- and CD10-. The medium-sized cells were CD20+, CD79a+, Bcl2+, Bcl6+ and CD10+, enmeshed in a network of CD21-positive follicular dendritic cells. Epstein-Barr virus detection was negative. Interphase fluorescence in situ hybridization showed the absence of BCL2 or BCL6 rearrangement. In such a case, the presence of Hodgkin-like cells intermixed with the tumor population may result in a pitfall diagnosis of classical Hodgkin lymphoma (CHL). Differential diagnoses to be ruled out are secondary or primary skin localization of rather CHL, or systemic follicular lymphoma. Several clinical, radiological, histological, immunohistochemical and molecular arguments indicated the diagnosis of PCFCL. To our knowledge, this is the first report of PCFCL with Hodgkin-like cells. PMID:25099172

Marie, Dilly; Houda, Ben-Rejeb; Béatrice, Vergier; Matthieu, Feldis; Louis, Toty; Olivier, Nohra; Marie, Beylot-Barry; Audrey, Gros; Jean-Philippe, Merlio; Marie, Parrens

2014-10-01

137

Effect of material deprivation on Epstein–Barr virus infection in Hodgkin’s disease in the West Midlands  

Microsoft Academic Search

We have used Townsend scores from postcode data to compare levels of material deprivation and Epstein–Barr virus (EBV)-positivity for 223 patients diagnosed with Hodgkin’s disease (HD) in the period 1981–1997. The presence of EBV in HD tumours was determined using in situ hybridization to target the abundantly expressed EBV early RNAs. EBV was detected in the malignant Hodgkin and Reed–Sternberg

K Flavell; C Constandinou; D Lowe; K Scott; C Newey; D Evans; A Dutton; S Simmons; R Smith; J Crocker; L S Young; P Murray

1999-01-01

138

Second cancers following non-Hodgkin's lymphoma  

Microsoft Academic Search

The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed\\/expected (O\\/E) = 1.18; O

Lois B. Travis; Rochelle E. Curtis; John D. Boice; Benjamin F. Hankey; Joseph F. Fraumeni

1991-01-01

139

Radioimmunotherapy of Non-Hodgkin's Lymphoma  

Microsoft Academic Search

The goal of this work was to determine an optimal radioimmu- notherapy agent for further development against non-Hodgkin's lymphoma. We sought to establish the stability profile of 90Y- labeled humanized LL2 (hLL2) monoclonal antibody (mAb) when prepared with different chelating agents and, from these data, to estimate the dosimetric improvement to be expected from use of the most stable 90Y-chelate-hLL2

Gary L. Griffiths; Serengulam V. Govindan; Robert M. Sharkey; Darrell R. Fisher; David M. Goldenberg

140

Histone deacetylase inhibitors in Hodgkin lymphoma  

Microsoft Academic Search

Summary  Although Hodgkin lymphoma (HL) is considered one of the most curable human cancers, the treatment of patients with relapsed\\u000a and refractory disease, especially those who relapse after autologous stem cell transplantation, remains challenging. Furthermore,\\u000a because of the young age of these patients, the impact of early mortality on the number of years lost from productive life\\u000a is remarkable. Patients with

Daniela Buglio; Anas Younes

2010-01-01

141

Immunotherapy of Non-Hodgkin's Lymphomas  

Microsoft Academic Search

Recent years have witnessed the development of a variety of promising immunotherapies for treating patients with non-Hodgkin's lymphomas. Foremost among these advances is the exciting success of monoclonal antibodies directed against lymphocyte surface antigens. Rituximab is a chimeric (human- mouse) anti-CD20 antibody that induces responses in approximately half of the patients with relapsed indolent lymphomas and a third of patients

John P. Leonard; Bertrand Coiffier; Ronald Levy; John Timmerman

142

Perceptions and uses of Chinese medicine among the chinese in Hong Kong  

Microsoft Academic Search

The present paper was based on both qualitative observations and quantitative survey data. Major findings are as follows: (1) The sacred or magical-religious tradition of Chinese medicine is accepted by a relatively small portion (roughly one-fifth) of the ordinary Chinese people in urban Hong Kong, and is relatively more popular among women or less educated people. (2) Both the classical-professional

Rance P. L. Lee

1980-01-01

143

Development of non-Hodgkin's lymphoma following therapy for Hodgkin's disease  

SciTech Connect

Three patients developed non-Hodgkin's lymphoma (NHL) 3 to 6 years after treatment for Hodgkin's disease (HD). In no instance was there evidence of recurrence of HD following the initial chemotherapy or radiotherapy. None of these patients had received both radiation therapy and chemotherapy. All patients responded well to conventional chemotherapy for NHL and are alive at 23 +, 37 +, and 65+ months after that secondary diagnosis. This report, when coupled with at least ten other such reported patients, suggests that NHL may be a relatively uncommon but significant complication of therapy for HD and must be distinguished for recurrence of HD.

Kim, H.D.; Bedetti, C.D.; Boggs, D.R.

1980-12-15

144

The Evolving Role of Radiotherapy in Early Stage Hodgkin’s Lymphoma  

PubMed Central

Radiation therapy has a key role in the combined modality treatment of early-stage Hodgkin’s Lymphoma (HL). Nevertheless, late toxicity still remains an issue. A modern approach in HL radiotherapy includes lower doses and smaller fields, together with the implementation of sophisticated and dedicated delivery techniques. Aim of the present review is to discuss the current role of radiotherapy and its potential future developments, with a focus on major clinical trials, technological advances and their repercussion in the clinical management of HL patients. PMID:24959332

Ricardi, Umberto; Filippi, Andrea Riccardo; Piva, Cristina; Franco, Pierfrancesco

2014-01-01

145

Interleukin-12 in Treating Patients With Previously Treated Non-Hodgkin's Lymphoma or Hodgkin's Disease  

ClinicalTrials.gov

Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Waldenström Macroglobulinemia

2013-01-22

146

Hodgkin's disease of the prostate: a detailed case report  

SciTech Connect

Malignant lymphoma of the prostate is an unusual entity, and nonHodgkin's lymphoma constitutes most reported cases. We report a well documented case of Hodgkin's lymphoma, initially involving the gastrointestinal tract and spleen, which recurred in the prostate following initial remission with chemotherapy. Treatment with external beam radiotherapy resulted in a rapid complete response that has been sustained for 18 months.

Klotz, L.H.; Herr, H.W.

1986-06-01

147

Neuralgic amyotrophy in association with radiation therapy for Hodgkin's disease  

SciTech Connect

We describe 4 patients with Hodgkin's disease who developed neuralgic amyotrophy in the setting of radiation therapy. In contrast to tumor progression or radiation plexopathy, the symptom onset was abrupt and occurred within days to weeks of receiving radiation treatments. There is an association between Hodgkin's disease, radiation therapy, and neuralgic amyotrophy.

Malow, B.A.; Dawson, D.M. (Brigham and Women's Hospital, Boston, MA (USA))

1991-03-01

148

Mammary carcinoma developing after radiotherapy and chemotherapy for Hodgkin's disease  

SciTech Connect

Two patients developed breast cancer after treatment of Hodgkin's disease. Both had received mediastinal irradiation 13 to 15 years, respectively, before the diagnosis of breast carcinoma. One patient had synchronous bilateral breast cancer when the diagnosis was made. Discussed is the risk of mammary carcinoma as a second malignant neoplasm in patients treated for Hodgkin's disease.

Janjan, N.A.; Wilson, J.F.; Gillin, M.; Anderson, T.; Greenberg, M.; Schewe, K.; Cox, J.D.

1988-01-15

149

Survey of Chinese radars  

Microsoft Academic Search

Open information on about 200 Chinese radars including earlier radars is now available. By number of model types China is an important radar country. This Chinese radar survey paper shows that Chinese radars cover a wide spectrum of civilian and military applications. Chinese civilian radars include air-borne weather avoidance\\/navigation, air traffic control (ASR, ARSR, GCA, SSR), harbor surveillance, industrial applications,

S. L. Johnston

1995-01-01

150

The Chinese in Houston.  

ERIC Educational Resources Information Center

There are between seven and eight thousand Chinese Americans living in Houston, but there has never been a predominantly Chinese neighborhood in the city. This lack of geographical focus has prevented the development of easily identifiable aspects of ethnic concentration, such as a Chinese school or a Chinese business district. Apart from the…

Woodell, Thomas M.

151

Traditional Chinese herbal medicine  

Microsoft Academic Search

Herbal medicine, acupuncture and moxibustion, and massage are the three major constituent parts of traditional Chinese medicine. Although acupuncture is well known in many Western countries, Chinese herbal medicine, the most important part of traditional Chinese medicine, is less well known in the West. This article gives a brief introduction to the written history, theory, and teaching of Chinese herbal

You-Ping Zhu; Herman J. Woerdenbag

1995-01-01

152

Non-Hodgkin’s Lymphoma in Buccal Vestibule -Case Report  

PubMed Central

Lymphomas are malignant neoplasms arising from lymphocytes B cell or T cell that affects mainly lymph nodes, spleen and other non hematopoietic tissues. They are classified as Hodgkin’s lymphoma (HL) and non-Hodgkin’s lymphoma (NHL). Diffuse large B-cell lymphoma (DLBL) is the most common variant of non-Hodgkin’s lymphomas and frequently involves extranodal sites. In the oral soft tissues lesions can occur as hard and diffuse tumors involving oral vestibule, gums and posterior region of the hard palate. Most lymphomas, including DLBL arise from B cells are characterized by diffuse population of large cells with cleaved or non cleaved oval nuclei. Both histopathlogical and immunohistochemical (IHC) analysis were strongly advisable for proper management and prognosis. We hereby report a rare case of Diffuse large B-cell variant of non-Hodgkin’s lymphoma in a male patient of age 50yrs in left upper buccal vestibule. PMID:25302245

G, Sreenath; Reddy Y, Raghavendra; Prakash A, Ravi; T R, Swathi

2014-01-01

153

The Hodgkin-Huxley Heritage: From Channels to Circuits  

PubMed Central

The Hodgkin-Huxley studies of the action potential, published 60 years ago, are a central pillar of modern neuroscience research, ranging from molecular investigations of the structural basis of ion channel function to the computational implications at circuit level. In this Symposium Review, we aim to demonstrate the ongoing impact of Hodgkin’s and Huxley’s ideas. The Hodgkin-Huxley model established a framework in which to describe the structural and functional properties of ion channels, including the mechanisms of ion permeation, selectivity, and gating. At a cellular level, the model is used to understand the conditions that control both the rate and timing of action potentials, essential for neural encoding of information. Finally, the Hodgkin-Huxley formalism is central to computational neuroscience to understand both neuronal integration and circuit level information processing, and how these mechanisms might have evolved to minimize energy cost. PMID:23055474

Catterall, William A.; Raman, Indira M.; Robinson, Hugh P. C.; Sejnowski, Terrence J.; Paulsen, Ole

2012-01-01

154

Lymphocyte predominance Hodgkin's disease. Evidence for a kappa light chain-restricted monotypic B-cell neoplasm.  

PubMed Central

Over the last decade, it has been noted that nodular lymphocytic and/or histiocytic predominance Hodgkin's disease (NLPHD) has clinical, histological, and immunophenotypical differences from classical Hodgkin's disease, but it is not clear whether NLPHD represents a B-cell neoplasm or merely an unusual B-lineage reactive condition. We evaluated 36 cases of LPHD (31 nodular, 5 diffuse) for evidence of B-cell clonality by immunohistochemistry for light-chain protein using polyclonal antibodies and microwave antigen retrieval, and by a highly sensitive in situ hybridization technique for light-chain mRNA using 3H-labeled antisense RNA probes. We found monotypic light-chain restriction for kappa protein in 36% of cases, with no clear predominance for either light-chain protein in the other cases. By in situ hybridization, 80% of the evaluable cases showed clear evidence of light-chain monotypsim, with 96% of cases monotypic for kappa mRNA and one case monotypic for lambda mRNA. In virtually all of these cases, the L&H cells were found to be monotypic, consistent with monoclonality. In about one-half of these cases, a small lymphocytic component was also found to be monotypic. Our data support the hypothesis that NLPHD and its rare diffuse variant represent a monotypic B-cell neoplasm, almost always of kappa light-chain type. NLPHD represents a neoplasm distinct from classical Hodgkin's disease. Images Figure 1 Figure 2 PMID:7717448

Stoler, M. H.; Nichols, G. E.; Symbula, M.; Weiss, L. M.

1995-01-01

155

Hodgkin lymphoma post-transplant lymphoproliferative disorder following pediatric renal transplant: serial imaging with F-18 FDG PET/CT.  

PubMed

Post-transplant lymphoproliferative disorder (PTLD) occurs in 1.2% of pediatric renal transplant patients, and is frequently Epstein-Barr Virus mediated. Hodgkin Lymphoma PTLD is the rarest of the 4 types of PTLDs recognized by the World Health Organization, with an incidence of <4% of all PTLD patients. It has a distinct clinical course and treatment from all other types of PTLD. This is a case of a 16-year-old girl who had a renal transplant in 2000 due to Moya Moya disease. Her first F-18 FDG PET/CT done in 2006 showed mildly FDG-avid mediastinal adenopathy (histologically nonspecific reactive nodes), however in 2009, after presenting with fevers, a repeat PET/CT showed extensive intensely FDG-avid disease. Biopsy of a supraclavicular node identified Hodgkin Lymphoma PTLD. The patient was treated with chemotherapy and reimaged, showing excellent response to therapy. In contrast, classic PTLD is treated by withdrawal of immunosuppression and administration of Rituximab. F-18 FDG PET/CT is known to be very useful in the staging and monitoring of response to therapy in the setting of classic PTLD. In this case, serial F-18 FDG PET/CT scans proved very useful in the evaluation and follow-up of the rare and distinct Hodgkin Lymphoma PTLD subtype. PMID:20706047

Makis, William; Lisbona, Robert; Derbekyan, Vilma

2010-09-01

156

CPI-613 and Bendamustine Hydrochloride in Treating Patients With Relapsed or Refractory T-Cell Non-Hodgkin Lymphoma or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Lymphocyte Depletion Hodgkin Lymphoma; Adult Lymphocyte Predominant Hodgkin Lymphoma; Adult Mixed Cellularity Hodgkin Lymphoma; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Adult Nodular Sclerosis Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Hepatosplenic T-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; T-cell Adult Acute Lymphoblastic Leukemia; T-cell Large Granular Lymphocyte Leukemia

2014-10-31

157

Differentiation of EBV-induced post-transplant Hodgkin lymphoma from Hodgkin-like post-transplant lymphoproliferative disease.  

PubMed

The development of lymphomas after SOT is a well-known complication of the immunosuppressive therapy necessary to prevent graft rejection. Epstein-Barr virus plays a central role in the pathogenesis of lymphomas because of its ability to transform infected cells. Differentiating PTLD from malignant lymphomas, especially HL can be challenging. We report on two patients, who developed EBV-associated lymphomas several years after SOT. A histological examination of lymph nodes led to a diagnosis of HL in both patients, who were started on chemotherapy according to current treatment protocols. A rapid and complete remission in one patient prompted us to analyze the expression pattern of EBV-latency genes. In this patient, the EBV expression profile revealed a latency type III suggesting the diagnosis of Hodgkin-like PTLD. The other patient required six courses of chemotherapy plus radiotherapy to reach a complete remission. In his tumor cells, a restricted EBV-latency type II pattern was found, suggesting a diagnosis of classical HL. These two cases demonstrate that in post-transplant lymphomas with histological features of HL, an analysis of the expression pattern of EBV proteins might aid in the differentiation between PTLD and HL. PMID:18466428

Rohr, Jan C; Wagner, Hans J; Lauten, Melchior; Wacker, Hans H; Jüttner, Eva; Hanke, Christof; Pohl, Martin; Niemeyer, Charlotte M

2008-06-01

158

Pathology Case Study: History of Hodgkin's Disease  

NSDL National Science Digital Library

This is a case study presented by the University of Pittsburgh Department of Pathology in which a 37-year-old man, previously diagnosed with stage III nodular sclerosing Hodgkin's Disease has recently had a brief episode of syncope. Visitors are given the gross descriptions and radiology, including images, and are given the opportunity to diagnose the patient. This is an excellent resource for students in the health sciences to familiarize themselves with using patient history and laboratory results to diagnose disease. It is also a helpful site for educators to use to introduce or test student learning in neuropathology.

Brown, Henry G.

159

Fatal measles pneumonitis during Hodgkin's lymphoma.  

PubMed

The treatment of measles pneumonitis in immunocompromised adults is not established. We describe a patient with Hodgkin's lymphoma who developed acute pneumonia during a measles infection. On day 13, intravenous ribavirin and immunoglobulins were administrated. On day 18, the patient developed acute respiratory failure. An examination of transbronchial pulmonary biopsies showed Warthin-Finkeldey giant cells that are pathognomonic of measles pneumonitis. The patient died despite aggressive supportive care. Our case and a review of literature show that measles pneumonitis is routinely fatal in patients with cancer. We suggest that antiviral drugs should be considered as soon as the diagnosis has been established. PMID:24105383

Wyplosz, Benjamin; Lafarge, Marion; Escaut, Lélia; Stern, Jean-Baptiste

2013-01-01

160

Adrenal involvement in non-Hodgkin lymphoma  

SciTech Connect

Adrenal masses are described in seven cases of non-Hodgkin lymphoma in a series of 173 patients. In all seven patients the lymphoma was diffuse rather than nodular. Three patients had adrenal masses at the time of presentation, whereas in four cases the adrenal gland was a site of tumor recurrence after therapy. Three patients had simultaneous bilateral adrenal involvement by tumor. No characteristic features were recognized that might have distinguished these tumors from other adrenal masses. Appropriate therapy successfully resolved the adrenal masses in all but one case. The latter patient was the only one with evidence of adrenal insufficiency.

Paling, M.R.; Williamson, B.R.J.

1983-08-01

161

Assessment of clonality of rosetting T lymphocytes in Hodgkin's disease by single-cell polymerase chain reaction: detection of clonality in a polyclonal background in a case of lymphocyte predominance Hodgkin's disease.  

PubMed

Rosetting of CD4+ T cells around the neoplastic Hodgkin and Reed-Sternberg (H&RS) cells is a characteristic feature of Hodgkin's disease (HD). To answer the question whether this phenomenon is solely due to chemokine-mediated attraction of T cells or whether the rosetting T cells in addition recognize antigens presented by the H&RS cells, we examined the T cells adherent to H&RS cells. Cells from five cases of HD [four classic HD and one lymphocyte-predominant (LP) HD] were examined by single-cell analysis for the T-cell receptor (TCR) gamma gene. Between 5 and 17 rosettes containing one to ten rosetting lymphocytes and the corresponding H&RS cells were amplified in separate plastic tubes. Of the resulting 119 TCRgamma polymerase chain reaction (PCR) products, 87 were sequenced. While no evidence of a clonal expansion was obtained in the lymph nodes from four of five patients with classic HD, clonal TCRgamma sequences were found in the lymph node from the patient within LPHD in two independent experiments analyzing seven and ten different rosetting complexes, respectively. Of 13 products, 11 showed identical Vgamma9 sequences. Unrelated products were found in all other TCRgamma family subgroups in this case. Single H&RS cells picked as controls were negative for TCRgamma rearrangements. Our results demonstrate that clonal proliferations on a polyclonal background can occur among the T cells forming rosettes with Hodgkin cells and lend support to the view that Hodgkin cells may also function as cells presenting antigens to the adhering T cells. PMID:11757724

Trümper, L; Jung, W; Daus, H; Mechtersheimer, G; von Bonin, F; Pfreundschuh, M

2001-11-01

162

Second cancers following non-Hodgkin's lymphoma  

SciTech Connect

The risk of second malignancies following non-Hodgkin's lymphoma (NHL) was estimated in 29,153 patients diagnosed with NHL between 1973 and 1987 in one of nine areas participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results Program. Compared with the general population, NHL patients were at a significantly increased risk of developing second cancers (observed/expected (O/E) = 1.18; O = 1231). The O/E ratio increased significantly with time to reach 1.77 in 10-year survivors. Significant excesses were noted for acute nonlymphocytic leukemia (O/E = 2.88), cancers of the bladder (O/E = 1.30), kidney (O/E = 1.47), and lung (O/E = 1.57), malignant melanoma (O/E = 2.44), and Hodgkin's disease (O/E = 4.16). Chemotherapy appeared related to subsequent acute nonlymphocytic leukemia (ANLL) and bladder cancer. Radiation therapy was associated with ANLL and possibly cancers of the lung, bladder, and bone. Malignant melanoma was not clearly related to initial NHL treatment.

Travis, L.B.; Curtis, R.E.; Boice, J.D. Jr.; Hankey, B.F.; Fraumeni, J.F. Jr. (National Cancer Institute, Bethesda, MD (USA))

1991-04-01

163

The treatment of stage IIIA Hodgkin's disease  

SciTech Connect

Sixty consecutive previously untreated adults with surgically confirmed stage IIIA Hodgkin's disease (39 stage IIIA1, 21 stage IIIA2) began therapy at St. Bartholomew's Hospital between 1969 and 1981. Prior to 1973, treatment consisted of total nodal irradiation (TNI). From 1973 until 1978 patients were randomly allocated to receive either TNI or cyclic combination chemotherapy of mustine, vinblastine, prednisolone, and procarbazine (MVPP) as part of a Medical Research Council Trial. Since 1978 treatment has been allocated according to substage, those with stage IIIA1 receiving TNI and those with stage IIIA2 receiving MVPP. Seven patients received ''non protocol'' therapy (extended mantle radiotherapy in three patients, mantle and MVPP in four patients), and have been excluded from the study. Complete remission was achieved in 48 of 53 patients regardless of substage or therapy. Seven have relapsed, one after MVPP and six after TNI. The predicted freedom-from-relapse after MVPP was 96% compared with 60% after TNI, both at 10 years (p less than 0.01). The relapse pattern was the same for both substages in the group receiving TNI. Although overall survival of patients receiving TNI was identical to that of those receiving MVPP, TNI must be considered inappropriate therapy for stage IIIA Hodgkin's disease if permanent freedom-from-recurrence is the goal.

Lister, T.A.; Dorreen, M.S.; Faux, M.; Jones, A.E.; Wrigley, P.F.

1983-12-01

164

Primary non-Hodgkin's lymphoma of bone.  

PubMed

Primary non-Hodgkin's lymphoma of bone (PLB) constitutes approximately 5% of all extranodal non-Hodgkin's lymphoma (NHL) and 7% of primary bone tumors. The peak incidence for PLB is in the fifth decade, with a slight preponderance of males over females. The presenting symptoms usually consist of localized bone pain and occasionally a palpable mass. Most patients with PLB have B-cell tumors with a diffuse mixed-cell or diffuse large cell histology. While most patients present with early-stage disease, it is not clear whether such patients benefit from combined-modality therapy (CMT) consisting of radiation therapy (RT) and chemotherapy (CT) compared with either RT or CT alone. However, there is strong evidence that CMT is beneficial in the treatment of localized NHL, and these results might be applicable to the therapy for PLB. Nevertheless, only a phase III randomized, controlled clinical trial will determine whether CMT is superior to either CT or RT alone. PMID:10375084

Baar, J; Burkes, R L; Gospodarowicz, M

1999-06-01

165

Thymic cysts following radiation therapy for Hodgkin disease  

SciTech Connect

In 3 patients, benign thymic cycsts developed following radiation therapy for Hodgkin disease. Autopsy or surgical specimens provided a diagnosis in all 3 cases; computed tomographic (CT) scans obtained in two of the patients provided a preoperative diagnosis. The etiology of these cysts is uncertain; they may arise following successful radiation treatment of Hodgkin disease involving the thymus. When an anterior mediastinal mass develops in a patient with Hodgkin disease following radiation therapy, careful evaluation to exclude a benign process is indicated prior to initiating additional therapy.

Baron, R.L.; Sagel, S.S.; Baglan, R.J.

1981-12-01

166

RAND Classics  

NSDL National Science Digital Library

The RAND Corporation has recently added selections from the writings of Albert Wohlstetter to its well known RAND Classics site. Wohlstetter "was a mathematical logician and senior staff member at RAND in the 1950s and 1960s.... His studies led to the 'second-strike' and 'Fail-Safe' concepts for deterring nuclear war. These and other methods reduced the probability of accidental war." At present, 24 selections are available, ranging from 1952 to 1970. More are forthcoming. In addition to Wohlstetter's writings, RAND Classics contains eleven of Paul Baran et al's twelve volume On Distributed Communications (1968), RAND's A Million Random Digits with 100,000 Normal Deviates (1955), and Toward an Ethics and Etiquette for Electronic Mail (1985), by Norman Z. Shapiro and Robert H. Anderson.

1998-01-01

167

Morphologic changes in the thyroid after irradiation for Hodgkin's and non-Hodgkin's lymphoma  

SciTech Connect

Four cases of thyroidectomy for suspected thyroid carcinoma after previous irradiation for Hodgkin's or non-Hodgkin's lymphoma are reviewed. The patients ranged in age from 18 to 33 years at the time of thyroid surgery with an average latency period of 12 years (range, 8-20 years) from radiation therapy to thyroidectomy. All patients had a clinically palpable thyroid nodule, and pathologically showed a pattern of multiple adenomatous nodules with cytologic atypia. The microscopic changes were sufficiently striking to cause the primary pathologist to request consultation to rule out thyroid carcinoma in each case. Fine-needle aspiration was performed in one case and suggested a thyroid neoplasm. The pathologic findings are reviewed and distinction of this lesion from thyroid carcinoma is discussed.

Carr, R.F.; LiVolsi, V.A.

1989-08-15

168

Hodgkin disease and non-Hodgkin lymphomas in children: utilization of radiological modalities  

SciTech Connect

If costs of medical care are to be reduced, the choice of which imaging modality to use must be made as carefully as possible. This study was done to show how radiological modalities were used to evaluate patients with Hodgkin disease and non-Hodgkin lymphoma. We kept a record of every radiological study performed on 66 children with both diseases seen in the past 6 1/3 years. The results of these studies were analyzed to see which areas of the body were studied, which imaging modality was used, how frequently the studies were repeated, and how frequently the studies gave abnormal results. Our findings disclosed that radiological studies have been appropriately performed in anatomic regions of the body in which disease is present. New imaging modalities have been introduced, and the use of some of the older modalities has been decreased. With some modalities, such as skeletal survey, liver/spleen scan, whole-lung tomography, contrast studies of the bowel, and excretory urography, utilization is higher than it ought to be in view of the fact that the yield of positive results is low and the information is obtainable in many cases from other more sensitive procedures. These studies should not be performed as a routine on initial evaluation or follow-up of all patients with Hodgkin or non-Hodgkin lymphomas. On initial presentation all patients should undergo chest radiography and CT scanning of both chest and abdomen. A problem area is that the timing of follow-up studies has been somewhat erratic, with some inappropriate studies particularly 3 or 4 years after diagnosis. Too many imaging procedures have probably been done in follow-up of our patients.

Cohen, M.D.; Siddiqui, A.; Weetman, R.; Provisor, A.; Coates, T.

1986-02-01

169

Autologous Peripheral Blood Stem Cell Transplant Followed by Donor Bone Marrow Transplant in Treating Patients With High-Risk Hodgkin Lymphoma, Non-Hodgkin Lymphoma, Multiple Myeloma, or Chronic Lymphocytic Leukemia  

ClinicalTrials.gov

B-Cell Prolymphocytic Leukemia; Plasma Cell Leukemia; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Childhood Hodgkin Lymphoma; Recurrent Childhood Non-Hodgkin Lymphoma; Recurrent Chronic Lymphocytic Leukemia; Recurrent Plasma Cell Myeloma; Recurrent Small Lymphocytic Lymphoma; Refractory Childhood Hodgkin Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Non-Hodgkin Lymphoma; Refractory Plasma Cell Myeloma; Refractory Small Lymphocytic Lymphoma; T-Cell Prolymphocytic Leukemia; Waldenstrom Macroglobulinemia

2015-03-17

170

General Information about Childhood Non-Hodgkin Lymphoma  

MedlinePLUS

... non-Hodgkin lymphoma include breathing problems and swollen lymph nodes. These and other signs may be caused by ... or arms. Trouble swallowing. Painless swelling of the lymph nodes in the neck, underarm, stomach, or groin. Painless ...

171

General Information about Adult Non-Hodgkin Lymphoma  

MedlinePLUS

... called lymphoplasmacytic lymphoma. Age, gender, and a weakened immune system can affect the risk of adult non-Hodgkin ... the cancer cells to normal cells of the immune system. Certain factors affect prognosis (chance of recovery) and ...

172

Current approaches to the management of pediatric Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma is one of the few cancers that affect both adults and children. Cure rates for Hodgkin lymphoma remain among the best for pediatric cancers. However, cure is often associated with significant delayed effects of therapy, including an elevated risk for second malignancies, cardiotoxicity, pulmonary toxicity, and gonadal and non-gonadal endocrine dysfunction. Therefore, the aim of current treatment strategies is to further improve outcomes while minimizing therapy-related complications. At diagnosis, patients are classified into risk groups based on disease stage, and the presence of clinical, biologic, and serologic risk factors. In general, the most recent trials have intensified therapy in those patients with high-risk disease to improve disease control, and have limited therapy in those patients with low-risk disease to avoid secondary effects. In low-risk patients, multiple studies have been conducted to investigate limiting either radiation therapy or chemotherapy to prevent long-term side effects without affecting the excellent cure rate. In intermediate- and high-risk patients, many studies have examined intensifying therapy to improve event-free survival rates. In addition, response assessment by fluorine-18-2-fluoro-2-deoxy-D-glucose-positron emission tomography (FDG-PET) may be particularly important in pediatric Hodgkin lymphoma; it may allow modification of treatment to maximize treatment efficacy and minimize late effects of chemotherapy and radiation therapy. Despite the improvements in treatment for all stages of Hodgkin lymphoma, there is still a subgroup of patients who do not enter remission with initial therapy or relapse after initial response to therapy. Unfortunately, standard-dose salvage chemotherapy for relapsed disease has disappointing results in terms of overall survival since patients have typically already received intensive therapy. While there is no standard of care in terms of salvage chemotherapy, high-dose chemotherapy with autologous stem cell transplant (ASCT) rescue has become the standard of care for the majority of children with relapsed Hodgkin lymphoma. The use of allogeneic transplantation is controversial in relapsed or refractory Hodgkin lymphoma; because of the high transplant-related mortality, allogeneic transplant has not been associated with improved overall survival over ASCT. As more has been learned about the biologic mechanisms involved in Hodgkin lymphoma, biologically-based therapies are being investigated for use in this disease, both at initial diagnosis and relapse. Both immunotherapy and small molecules are being studied as possible therapeutic agents in Hodgkin lymphoma. Unfortunately, the vast majority of investigations of novel agents have occurred exclusively in adult patients. However, since pediatric Hodgkin lymphoma and adult Hodgkin lymphoma are similar, these results may potentially be extrapolated to pediatric Hodgkin lymphoma. PMID:20218745

Freed, Jennifer; Kelly, Kara M

2010-04-01

173

Computers and Chinese Linguistics.  

ERIC Educational Resources Information Center

This survey of the field of Chinese language computational linguistics was prepared as a background study for the Chinese Linguistics Project at Princeton. Since the authors' main purpose was "critical reconnaissance," quantitative emphasis is on systems with which they are most familiar. The complexity of the Chinese writing system has presented…

Kierman, Frank A.; Barber, Elizabeth

174

Agricultural exposures and non-Hodgkin's lymphoma.  

PubMed

Farmers have an increased risk of non-Hodgkin's lymphoma (NHL), several studies have found increased risks of NHL among producers or sprayers of pesticides. The findings are markedly inconsistent across countries and studies, but overall there is evidence of an increased risk among production workers and professional pesticide sprayers with heavy exposures. However, this increased risk does not appear to be confined to workers exposed to phenoxy herbicides containing 2,3,7,8-tetrachlorodibenzo-p-dioxin, and it may be due to phenoxy herbicide exposure itself rather than to the dioxin contaminants. Other pesticide exposures, including organochlorine and organophosphorous insecticides, have also been associated with NHL in some studies, as have nitrates in drinking water. Farmers may also have exposure to oncogenic viruses carried by farm animals, and studies of slaughterhouse workers and meat inspectors have found increased risks of NHL. PMID:16190145

Pearce, Neil; McLean, Dave

2005-01-01

175

Studies of Traditional Chinese Poet Identification Based on Machine Learning  

Microsoft Academic Search

Based on machine learning methods-Naïve Baye, this paper proposes a Traditional Chinese Poetry anthor Identification Calculation to identify Libai or Dufu. That derive from Machine Learning Chinese Classical Poem in Tang dynasty. Vector space Model is the Knowledge representation of poetic text. Feature subset selection is peformed base on information gain and hill-climbling strategy. The 98.3% satifatictory accuracy rate is

YING Yong; ZHENG Yan; LI Liang-yan

176

Advanced studies on traditional Chinese poetry style identification  

Microsoft Academic Search

Based on machine learning methods - naive Bayes, hill-climbing strategy and genetic algorithm, this paper proposes a traditional Chinese poetry style identification calculation improvement model to identify bold-and-unrestrained or graceful-and-restrained styles, that derive from machine learning Chinese classical Ci in Song Dynasty. Feature subset selection is performed based on genetic algorithm and has achieved satisfactory identification results in application. Additionally,

Yong Yi; Zhong-Shi He; Liang-Yan Li; Tian Yu; Elaine Yi

2005-01-01

177

Lymphocyte-Predominant Hodgkin's Disease in Children: A Case Study and Review of the Literature  

PubMed Central

A three-year-old boy presented with an enlarging neck mass. Biopsy demonstrated IgD-positive nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL), which was staged as IIa. The patient received cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) with rituximab and had excellent results. NLPHL is a relatively rare disease that is biologically distinct from classic Hodgkin lymphoma (cHL). NLPHL is a B-cell malignancy likely of germinal center origin that has an overall good prognosis and favorable response to treatment. Unlike cHL, NLPHL is ubiquitously CD20-positive. Recent evidence supports the efficacy of targeted anti-CD20 therapy in NLPHL, though prospective data is limited. This case demonstrates several unique features of NLPHL and further supports the use of rituximab in front-line therapy. The clinical characteristics among patients at various ages are discussed with a special focus on the IgD-positive subtype. A thorough literature search demonstrates this to be the youngest patient with NLPHL yet described. PMID:25878913

Stier, James R.; Vasquez, Robert J.

2015-01-01

178

Flow sorting and exome sequencing reveal the oncogenome of primary Hodgkin and Reed-Sternberg cells.  

PubMed

Classical Hodgkin lymphoma (cHL) is characterized by sparsely distributed Hodgkin and Reed-Sternberg (HRS) cells amid reactive host background, complicating the acquisition of neoplastic DNA without extensive background contamination. We overcame this limitation by using flow-sorted HRS and intratumor T cells and optimized low-input exome sequencing of 10 patient samples to reveal alterations in genes involved in antigen presentation, chromosome integrity, transcriptional regulation, and ubiquitination. ?-2-microglobulin (B2M) is the most commonly altered gene in HRS cells, with 7 of 10 cases having inactivating mutations that lead to loss of major histocompatibility complex class I (MHC-I) expression. Enforced wild-type B2M expression in a cHL cell line restored MHC-I expression. In an extended cohort of 145 patients, the absence of B2M protein in the HRS cells was associated with lower stage of disease, younger age at diagnosis, and better overall and progression-free survival. B2M-deficient cases encompassed most of the nodular sclerosis subtype cases and only a minority of mixed cellularity cases, suggesting that B2M deficiency determines the tumor microenvironment and may define a major subset of cHL that has more uniform clinical and morphologic features. In addition, we report previously unknown genetic alterations that may render selected patients sensitive to specific targeted therapies. PMID:25488972

Reichel, Jonathan; Chadburn, Amy; Rubinstein, Paul G; Giulino-Roth, Lisa; Tam, Wayne; Liu, Yifang; Gaiolla, Rafael; Eng, Kenneth; Brody, Joshua; Inghirami, Giorgio; Carlo-Stella, Carmelo; Santoro, Armando; Rahal, Daoud; Totonchy, Jennifer; Elemento, Olivier; Cesarman, Ethel; Roshal, Mikhail

2015-02-12

179

Hodgkin’s Disease in the Elderly : A Retrospective Clinicopathologic Study of 61 Patients Aged over 60 Years  

Microsoft Academic Search

61 cases of Hodgkin’s disease (HD) with age over sixty years were diagnosed in a series of 387 patients. Mixed cellularity (57.4%) and nodular sclerosis (14.7%) were the most common histologic subtypes. Clinical presentation was characterized by superficial lymphadenopathy (92%) and\\/or general symptoms (57.4%). Mediastinal involvement was observed in 24.6% of cases, and 24.6% of patients had a primitive infradiaphragmatic

Rossi Ferrini; A. Bosi; C. Casini; A. Messori; G. Bellesi

1987-01-01

180

Clinical and laboratory findings in untreated patients with Hodgkin’s disease with special reference to age  

Microsoft Academic Search

During a 6-yr period 258 adult patients (?15 yr) with biopsy verified Hodgkin’s disease (HD) were reported to the Stockholm-Gotland\\u000a Oncologic Center. In 57 elderly patients (mean age 74 yr) the diagnosis was established shortly before death or at autopsy.\\u000a One hundred and eighty-two of remaining 201 patients (118 men and 64 women, mean age 47 yr) were investigated. They

Christina Wedelin; Magnus Björkholm; Bo Johansson; Håkan Mellstedt

1984-01-01

181

Relationship of Serum Total IgE and Cell-Mediated Immunity in Patients with Hodgkin’s Disease  

Microsoft Academic Search

Thymus-derived lymphocytes have been shown to play a role in the regulation of IgE synthesis in the rat. Both anergy and elevated serum IgE levels may be present in patients with Hodgkin’s disease. Cell-mediated immunity (CMI) was investigated by measurement of delayed skin test reactions with five common antigens. Serum IgE levels were determined at the same time. Impaired CMI

Elliot Rubinstein; Joseph E. Sokal; Robert E. Reisman; Carl E. Arbesman

1977-01-01

182

Classics Unveiled  

NSDL National Science Digital Library

Classics Unveiled was developed by Neil Jenkins, Sumair Mirza and Jason Tang as a way to teach the web-browsing public about the various aspects of the ancient world, ranging from the massive world of Greek and Roman mythology, Roman history, Roman culture, and the Latin language and its pervasive influence on English. The site is divided into four primary areas, and visitors may opt to browse through any of them and their accompanying features, which include primary extended essays and informative games and quizzes. In Rome Exposed for example, users will learn about Roman residences, entertainment, attire, cuisine, and several other aspects of Roman culture and mores. In MythNET visitors can learn about the twelve Olympian gods, read about the Trojan War, and explore genealogical charts that trace the various relationships between the pantheon of Rome and Greece.

Jenkins, Neil

183

Whole-body FDG-PET imaging for staging of Hodgkin`s disease and lymphoma  

SciTech Connect

Accurate staging of Hodgkin`s disease (HD) and non-Hodgkin`s lymphoma (NHL) is important for treatment management. In this study, the utility of 2-[{sup 18}F]fluoro-2-deoxy-D-glucose (FDG) wholebody PET was evaluated as an imaging modality for initial staging or restaging of 7 HD and 11 NHL patients. Whole-body PET-based staging results were compared to the patient`s clinical stage based on conventional staging studies, which included combinations of CT of the chest, abdomen and pelvis, MRI scans, gallium scans, lymphangiograms, staging laparatomies and bone scans. Accurate staging was performed in 17 of 18 patients using a whole-body PET-based staging algorithm compared to the conventional staging algorithm in 15 of 18 patients. In 5 of 18 patients, whole-body PET-based staging showed additional lesions not detected by conventional staging modalities, whereas conventional staging demonstrated additional lesions in 4 of 18 patients not detected by whole-body PET. The total cost of conventional staging was $66,292 for 16 CT chest scans, 16 CT abdominal/pelvis scans, three limited MRI scans, four bone scans, give gallium scans, two laparotomies and one lymphangiogram. In contrast, scans cost $36,250 for 18 whole-body PET studies and additional selected correlative studies: one plain film radiograph, one limited CT, one bone marrow san, one upper GI and one endoscopy. A whole-body FDG-PET-based staging algorithm may be an accurate and cost-effective method for staging or restaging HD and NHL. 10 refs., 7 figs., 2 tabs.

Hoh, C.K.; Glaspy, J.; Rosen, P. [Crump Institute of Biological Imaging, Los Angeles, CA (United States)] [and others

1997-03-01

184

What's New in Research and Treatment of Non-Hodgkin Lymphoma in Children?  

MedlinePLUS

... resources for non-Hodgkin lymphoma in children What’s new in research and treatment of non-Hodgkin lymphoma ... further treatment is not given. Clinical trials of new treatments Most children with NHL are treated at ...

185

Everolimus and Lenalidomide in Treating Patients With Relapsed or Refractory Non-Hodgkin or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Splenic Marginal Zone Lymphoma; Waldenstrom Macroglobulinemia

2014-03-05

186

Gene Expression Profiling for In Silico Microdissection of Hodgkin's Lymphoma Microenvironment and Identification of Prognostic Features  

PubMed Central

Gene expression profiling studies based on DNA microarrays have demonstrated their ability to define the interaction pathways between neoplastic and nonmalignant stromal cells in cancer tissues. During the past ten years, a number of approaches including microdissection have tried to resolve the variability in DNA microarray measurements stemming from cancer tissue sample heterogeneity. Another approach, designated as virtual or in silico microdissection, avoids the laborious and time-consuming step of anatomic microdissection. It consists of confronting the gene expression profiles of complex tissue samples to those of cell lines representative of different cell lineages, different differentiation stages, or different signaling pathways. This strategy has been used in recent studies aiming to analyze microenvironment alterations using gene expression profiling of nonmicrodissected classical Hodgkin lymphoma tissues in order to generate new prognostic factors. These recent contributions are detailed and discussed in the present paper. PMID:21197104

Bertucci, François; Chetaille, Bruno; Xerri, Luc

2011-01-01

187

Detection of clonal Hodgkin and Reed-Sternberg cells with identical somatically mutated and rearranged VH genes in different biopsies in relapsed Hodgkin's disease.  

PubMed

Hodgkin's disease (HD) represents a malignant lymphoma in which the putative malignant Hodgkin and Reed-Sternberg (H-RS) cells are rare and surrounded by abundant reactive cells. Single-cell analyses showed that H-RS cells regularly bear clonal Ig gene rearrangements. However, there is little information on the clinical evolution of HD in a given patient. In this study, we used the single-cell polymerase chain reaction (PCR) to identify H-RS cells with clonal Ig gene rearrangements in biopsy specimens of patients with relapsed HD. The obtained clonal variable region heavy-chain (VH) gene rearrangements were used to construct tumor-clone-specific oligonucleotides spanning the complementarity determining region (CDR) III and somatically mutated areas in the rearranged VH gene. A number of biopsies were obtained during a period of 3 years from two HD patients. H-RS cells with identical VH rearrangements were detected in two separate infiltrated lymph nodes from one patient with nodular sclerosis HD. In a second patient with mixed cellularity HD subtype, clonal VH rearrangements with identical sequences were detected in infiltrated spleen and two lymph node biopsies. Despite the high sensitivity of the PCR method used (one clonal cell in 10(5) mononuclear cells), residual H-RS cells were not found in peripheral blood, leukapheresis material, purified CD34(+) stem cells or bone marrow. The results show that different specimens from relapsed patients suffering from classical HD carry the same clonotypic IgH rearrangements with identical somatic mutations, demonstrating the persistence and the dissemination of a clonal tumor cell population. Thus, PCR assays with CDRIII-specific probes derived from clonal H-RS cells are of clinical importance in monitoring the dissemination of HD and tumor progression and could be useful for analysis of minimal residual disease after autologous stem cell transplantation. PMID:9763576

Vockerodt, M; Soares, M; Kanzler, H; Küppers, R; Kube, D; Hansmann, M L; Diehl, V; Tesch, H

1998-10-15

188

Tradition and Modernity in 20th Century Chinese Poetry Center for East Asian Studies  

E-print Network

Tradition and Modernity in 20th Century Chinese Poetry Rob Voigt Center for East Asian Studies centered around the uncomfort- able tensions between tradition and modernity. In this corpus study, we develop and auto- matically extract three features to show that the classical character of Chinese poetry

Pratt, Vaughan

189

Parallel Event-Driven Neural Network Simulations Using the Hodgkin-Huxley Neuron Model  

E-print Network

Parallel Event-Driven Neural Network Simulations Using the Hodgkin-Huxley Neuron Model Collin J called the Hodgkin-Huxley neuron[1]. We describe the conversion of this model into an event to determine the feasibility of this parallel event-driven Hodgkin-Huxley model and analyze its viability

Tropper, Carl

190

JOURNAL OF COMPUTATIONAL PHYSICS 40, 318-326 (1981) Numerical Solution of the Hodgkin-Huxley  

E-print Network

JOURNAL OF COMPUTATIONAL PHYSICS 40, 318-326 (1981) Numerical Solution of the Hodgkin for the solution of the Hodgkin-Huxley equations for the transmission of the nerve impulse in a moving coordinate sciences of which the Hodgkin-Huxley (HH) equations [1] for the transmission of a nerve impulse down

Clore, G. Marius

1981-01-01

191

Differences in the subthreshold dynamics of leaky integrate-and-fire and Hodgkin-Huxley neuron  

E-print Network

Differences in the subthreshold dynamics of leaky integrate-and-fire and Hodgkin-Huxley neuron a leaky integrate- and-fire neuron with the first-spike time of a Hodgkin-Huxley neuron. We further and Hodgkin-Huxley (HH) nodes to stochastic input has been shown to differ [4], and divergent network

Trappenberg, Thomas

192

Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma  

E-print Network

Polymorphisms in cytochrome P450 17A1 and risk of non-Hodgkin lymphoma Immune function, believed of lymphoproliferative diseases such as non- Hodgkin lymphoma (NHL) may be influenced by hormonal modulation. Few studies )34T>C and CYP17A1 IVS2 105A>C polymorphisms were analyzed in a non-Hodgkin lymphoma (NHL) population

California at Berkeley, University of

193

Behavior of integrate-and-fire and Hodgkin-Huxley models with correlated inputs Jianfeng Feng  

E-print Network

Behavior of integrate-and-fire and Hodgkin-Huxley models with correlated inputs Jianfeng Feng COGS correlated Poisson inputs affect the output of the integrate-and-fire and Hodgkin-Huxley models correlation, and of the ratio between inhibitory and excitatory inputs. Interestingly for the Hodgkin

Feng, Jianfeng

194

Polymorphisms in innate immunity genes and risk of non-Hodgkin lymphoma  

E-print Network

Polymorphisms in innate immunity genes and risk of non- Hodgkin lymphoma Immunosuppression and infections have been associated with increased risk of non-Hodgkin lymphoma (NHL) and NHL subtypes-pathogen defence mechanisms and promote aberrant immune responses and non-Hodgkin lymphoma (NHL). To test

California at Berkeley, University of

195

Differences in Nuclear DNA Organization Between Lymphocytes, Hodgkin and ReedSternberg Cells Revealed  

E-print Network

Differences in Nuclear DNA Organization Between Lymphocytes, Hodgkin and Reed­Sternberg Cells lymphocytes, Hodgkin cells and Reed­ Sternberg cells using 3D structured illumination microscopy (SIM). We, progressive increase in the amount of sub-micron structures from control lymphocytes to Hodgkin cells to Reed

van Vliet, Lucas J.

196

Polymorphisms in Ghrelin and Neuropeptide Y Genes Are Associated with Non-Hodgkin Lymphoma  

E-print Network

Polymorphisms in Ghrelin and Neuropeptide Y Genes Are Associated with Non-Hodgkin Lymphoma Danica R and leptin receptor genes that are involved in body weight regulation, and non-Hodgkin lymphoma (NHL), and some cancers (3), including non- Hodgkin lymphoma (NHL). However, the mechanism under- lying

California at Berkeley, University of

197

Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model  

E-print Network

Determining the contributions of divisive and subtractive feedback in the Hodgkin-Huxley model 2014 Abstract The Hodgkin-Huxley (HH) model is the basis for numerous neural models. There are two to the dynamics in Type I versus Type II neurons. Keywords Hodgkin-Huxley . Negative feedback . Rhythmic spiking

Aluffi, Paolo

198

Biophysical Synaptic Dynamics in an Analog VLSI Network of Hodgkin-Huxley Neurons  

E-print Network

Biophysical Synaptic Dynamics in an Analog VLSI Network of Hodgkin-Huxley Neurons Theodore Yu1 in an analog VLSI silicon microchip. The four neurons implement a gen- eralized Hodgkin-Huxley model to interface with biological systems as a prosthesis. Here we present a network of Hodgkin-Huxley [2] neurons

Cauwenberghs, Gert

199

Second malignant lesions after therapy for Hodgkin's disease  

SciTech Connect

Among 169 adult pathologically staged patients with Hodgkin's disease who were treated at the Mayo Clinic between 1974 and 1978, four cases of second malignant lesions were identified. The median duration of follow-up after diagnosis for the entire population was 4.1 years. Of the 169 patients, 73 received irradiation only, 19 received chemotherapy only, and 77 received both chemotherapy and radiation therapy. In all four patients with second malignant lesions, Hodgkin's disease was in apparent remission at the time of diagnosis of the second tumor. These four patients had received either total nodal irradiation or six or more cycles of chemotherapy as initial treatment (and one of them had received both treatment modalities). Thus, intensive therapy might be hypothesized to have played a role in the development of the second malignant tumor. The development of non-Hodgkin's lymphoma within a previously irradiated field after treatment of Hodgkin's disease with radiation therapy only is not know to have been reported previously. Although further studies with longer follow-up should be conducted, this analysis supports a definite risk for development of a second malignant lesion not only after combined-modality treatment or chemotherapy for Hodgkin's disease but also after irradiation only.

Schomberg, P.J.; Evans, R.G.; Banks, P.M.; White, W.L.; O'Connell, M.J.; Earle, J.D.

1984-07-01

200

[Hodgkin disease and autoimmunity in children: 11 case reports].  

PubMed

The association of lymphoma and autoimmune manifestations has been predominantly studied in adults affected by non-Hodgkin lymphoma. Few publications exist in the literature concerning Hodgkin lymphoma, particularly in children and adolescents. The objectives of this study were to define the characteristics of the link between Hodgkin disease and autoimmunity in childhood. The present 25-year retrospective study was conducted in all centers affiliated with the French Society of Paediatric Oncology (SFCE). Eleven children with Hodgkin disease presented manifestations of disimmunity preceding or following their diagnosis. Four patients had thrombocytopenic purpura, the remaining 7 each had a different autoimmune pathology: lupus syndrome, antiphospholipid syndrome with transient ischemic attack, Evans syndrome, leukocytoclastic vasculitis, autoimmune hemolytic anemia, autoimmune thyroiditis, and juvenile idiopathic arthritis. Lymphoma relapse occurred in 3 patients. Two children died, death being directly attributed to the autoimmune disease in 1 case. Our data suggest that development of autoimmunity is related to significant morbidity. Possible pathophysiological mechanisms include lymphocyte proliferation secondary to chronic inflammation, cell-mediated immune deficiency in Hodgkin disease, molecular mimetics, and antineoplastic phenomena are discussed. A study with a larger patient population is needed to identify the group of children at high risk of autoimmunity for whom additional investigations and modified therapy may be indicated. PMID:21397466

Jarrassé, C; Pagnier, A; Edan, C; Landman-Parker, J; Mazingue, F; Mansuy, L; Bertrand, Y; Paillard, C; Pellier, I; Margueritte, G; Plantaz, D

2011-04-01

201

Learn Chinese Characters  

NSDL National Science Digital Library

Zhongwen.com is a valuable online resource for individuals just beginning to learn Chinese, as well as those who want to learn more. The site contains the complete on line text of "Chinese Character: A Genealogy and Dictionary". All the Chinese characters are hyperlinked so that users of the site can quickly decipher new and unfamiliar characters in English. Additionally, the site has readings about Chinese culture written in Chinese such as the "Art of War" and "Mao Sayings". Finally, for those who may just have basic questions about the Chinese language there is a frequently asked questions section that addresses common questions such as "Why are characters so complicated?" and "Are they pictures?"

Harbaugh, Rick

202

Diet and non-Hodgkin's lymphoma risk  

PubMed Central

Background The role of dietary factors in the epidemiology of Non-Hodgkin's lymphoma (NHL) remains largely undefined. Dietary habits may play a role in the etiology of NHL by influencing the immune system. Methods Dietary patterns and the risk of NHL were analyzed in a case control study; including 170 NHL cases and 190 controls. All subjects completed a validated food-frequency questionnaire. The dietary pattern was investigated separately and in nine nutritional groups. Crosstab tables were used to estimate the odds ratios (OR), and Ptrend. Results Consumption of highest versus lowest quartile of proteins (OR, 8.088 Ptrend=0.000), fats (OR, 6.17 Ptrend=0.000) and sweets (OR, 8.806 Ptrend=0.000) were associated with a significantly increased NHL risk. The inverse association was found for fresh fruits (OR, 0.117 Ptrend=0.000) and vegetables (OR, 0.461 Ptrend=0.010). Conclusion An association between dietary intake and the risk of NHL is biologically plausible due to immunosuppressive effects of fat and animal proteins, and antioxidant properties of vegetables and fruits. PMID:22937193

Mozaheb, Zahra; Aledavood, Amir; Farzad, Farzaneh

2012-01-01

203

Hodgkin's disease: thyroid dysfunction following external irradiation  

SciTech Connect

The thyroid gland is commonly included in the field of radiation therapy for patients with malignant lymphoma and with head and neck tumors. The radiation dose for malignant diseases varies considerably depending on the purpose of treatment and the institutional policies. A substantial number of these patients are developing subclinical and clinical hypothyroidism. The risk of developing hypothyroidism after a moderate radiation dose of 2000 to 4500 rads has been reported to be 10 to 20 percent. In addition, subclinical hypothyroidism is induced further in one third of the patients. There are also suggestions that external irradiation of the thyroid gland in patients with malignant lymphomas, as well as internal irradiation with radioiodine of the normal and hyperthyroid human thyroid glands, would induce elevations of serum antithyroid autoantibody titers. However, only a few cases of Graves disease following irradiation to the thyroid gland have been reported. We encountered a young woman who received radiation therapy to the mantle field for her Hodgkin's disease and developed hypothyroxinemia without overt signs and symptoms of hypothyroidism, followed by appearance of nodular goiter and then full-blown Graves disease.

Tamura, K.; Shimaoka, K.

1981-01-01

204

Management of Stage IIIA Hodgkin's disease  

SciTech Connect

Forty patients with pathological Stage IIIA Hodgkin's disease were allocated to receive either total modal irradiation (TNI) or 6 cycles of chemotherapy with Nitrogen Mustard (Mustine), Vinblastine, Procarbazine and Prednisolone (MVPP) as initial treatment. The complete remission rate for both groups was 100%, with 5-year actuarial disease-free survival figures of 74 and 87% for TNI and MVPP respectively (median duration of follow-up= 48 months). Eighty-eight percent of TNI treated patients were alive at 5 years compared with 100% in the MVPP group. Three patients died, two who were treated with TNI and one who received MVPP. Treatment related morbidity included one patient with osteonecrosis and one with a second malignancy. Given the length of follow-up available, these results demonstrate no significant difference between TNI and MVPP for patients with Stage IIIA disease; it is unlikely that further patient entry into this particular study will allow any conclusion to be reached regarding the optimal form of management. We would recommend that individual disease characteristics within Stage IIIA be used as a basis for future treatment decisions with the understanding that further information regarding morbidity may become available with prolonged follow-up.

Timothy, A.R.; Sutcliffe, S.B.J.; Lister, A.; Wrigley, P.F.M.; Jones, A.E.

1980-02-01

205

[Primary non-Hodgkin's lymphoma of bone].  

PubMed

Primary lymphoma of bone is a rare condition that has been described as a malignant neoplasm formed of lymphoid and myelopoetic tissues. Morphologic substrate is formed of lymphoid cells of different evolutional stages. Primary lymphoma of bone occurs predominantly in males; a male to female ratio is 1.8:1. It may occur at any age. The sites commonly affected are the long bones. In Lithuania 400 new cases of lymphoma are diagnosed every year. About 75% of them are non-Hodgkin's lymphoma. Many histological types and subtypes of lymphoma exist. This variation leads to difficulties when reviewing the literature and comparing prognoses, treatment and oncologic outcomes. Treatment options for primary bone lymphoma historically have included local therapy with radiation or surgery with or without systemic therapy. The aim of surgery is prophylactic fixation of impending fractures or treatment of pathological fractures. We present a clinical case report of 40-year-old male who developed primary lymphoma of bone with pathological fracture of femur. The systemic chemotherapy was applied during the time of treatment. The choice of surgical treatment was intramedullary nailing without using of methylmethacrylate, because regeneration of bone was visible on roentgenograms. After twelve-month follow-up the patient is full weight bearing without external support. PMID:15111754

Toliusis, Vytautas; Pamerneckas, Algimantas; Petrulis, Algimantas; Tamulaitis, Gintaras; Pilipavicius, Giedrius; Pijadin, Andrejus

2004-01-01

206

[Chemotherapy for non-Hodgkin's lymphoma].  

PubMed

This review highlights the role of chemotherapy for intermediate grade non-Hodgkin's lymphoma (NHL) including immunoblastic large cell lymphoma and low grade NHL. The combined modality treatment (CMT) consisting of chemotherapy including adriamycin (ADM) and involved-field irradiation (IFI) is considered standard therapy for localized intermediate grade NHL since a superior outcome (long-term disease-free survival rate is about 80%) can be obtained by CMT. However, developing dose-intensified regimens in initial chemotherapy will change the role of IFI. The phase II study using second and third generation regimens for advanced intermediate grade NHL showed a better outcome than first generation regimen CHOP. Unfortunately, the recent phase III intergroup trial concluded that none of the second or third generation treatment was superior to CHOP, and this regimen is now considered to be standard chemotherapy. However, the cure rate of the CHOP regimen (about 30%) is not satisfactory, and efforts should be underway to develop promising regimens with significantly increased dose intensity. While radiotherapy such as IFI, extended-field irradiation and total lymph node irradiation for localized low grade NHL obtained a more than 50% disease-free survival rate, the role of chemotherapy remains controversial. To date, many randomized trials of single agent chemotherapy regimen, combination chemotherapies with or without ADM, and CMT have shown no overall survival benefit for advanced low grade NHL, so there is no standard therapy for it. PMID:9881077

Kuraishi, Y; Usui, N; Dobashi, N

1998-12-01

207

Vitamin D3 receptor is highly expressed in Hodgkin’s lymphoma  

PubMed Central

Background Hodgkin lymphoma (HL) is one of the most frequent lymphoma in the western world. Despite a good overall prognosis, some patients suffer relapsing tumors which are difficult to cure. Over a long period Vitamin D has been shown to be a potential treatment for cancer. Vitamin D acts via the vitamin D receptor, a nuclear receptor, acting as an inducible transcription factor. We aimed to investigate the expression of vitamin D receptor as a possible diagnostic marker and potential therapeutic target in HL as well as in B-cell derived non-Hodgkin lymphoma (B-NHL). Methods We used a panel of 193 formalin fixed tissues of lymphoma cases consisting of 55 cases of HL and 138 cases on several B-NHL entities. Results Vitamin D receptor is strongly expressed in tumor cells of HL, regardless of the sub entity with an overall positivity of 80% of all HL cases. In contrast, only about 17% of the analyzed origin-NHL showed positivity for vitamin D receptor. The detection of nuclear localization of vitamin D receptor in the tumor cells of HL suggests activated status of the vitamin D receptor. Conclusions Our study suggests VDR as a specific marker for tumor cells of HL, but not of B-NHL subtypes. Further, the observed nuclear localization suggests an activated receptor status in tumor cells of HL. Further investigations of mutational status and functional studies may shed some light in functional relevance of vitamin D receptor signaling in HL. PMID:22672495

2012-01-01

208

Aurora B kinase in Hodgkin lymphoma: immunohistochemical pattern of expression in neoplastic Hodgkin and Reed-Sternberg cells.  

PubMed

Aurora B is a member of the chromosomal passenger complex, which is essential for proper completion of mitosis and cell division (cytokinesis). Inappropriate chromosomal segregation and cytokinesis due to deregulated expression of chromosome passenger proteins may lead to aneuploidy and cancer including lymphomas. According to our knowledge there are extremely limited studies investigating the immunohistochemical expression of Aurora B in tumor specimens of Hodgkin lymphoma. Our purpose was to characterize the expression of Aurora B in biopsies of Hodgkin lymphomas, and to evaluate the pattern of immunoreactivity in neoplastic Hodgkin and Reed-Sternberg cells (RS cells). We examined Aurora B immunoreactivity in paraffin sections of 15 samples of Hodgkin lymphomas, obtained from 15 patients, 8 men and 7 women. Ten were of nodular sclerosis type and five were of mixed cellularity. Our results showed immunoexpression of Aurora B in mononuclear lymphoid cells as well as in bi- and multinucleated RS cells. In addition, positive neoplastic cells in mitosis were observed, whereas a subpopulation without evidence of immunoreaction was also detected in each case. Taken together our results point to a possible association between Aurora B expression and mitotic deregulation in Hodgkin lymphoma, which may provide novel targets for treatment. PMID:24366835

Ioannou, M; Kouvaras, E; Stathakis, E; Samara, M; Koukoulis, G K

2014-08-01

209

Lenalidomide and Temsirolimus in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-Cell Lymphoma; AIDS-Related Hodgkin Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Cutaneous B-Cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue; Hepatosplenic T-Cell Lymphoma; Intraocular Lymphoma; Lymphomatous Involvement of Non-Cutaneous Extranodal Site; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Nodal Marginal Zone Lymphoma; Post-Transplant Lymphoproliferative Disorder; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma; Recurrent Cutaneous T-Cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides and Sezary Syndrome; Small Intestinal Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2015-03-02

210

Hodgkin's Lymphoma Revealed by Hemophagocytic Lymphohistiocytosis in a Child  

PubMed Central

Hemophagocytic lymphohistiocytosis (HLH) is a severe life-threatening disorder, responsible for extensive phagocytosis of hematopoietic cells and causing a multisystem organ failure. If lymphomas are common causes of HLH, the association with Hodgkin's lymphoma is rarely described in children. We report a case of a 9-year-old boy presenting with HLH as an initial manifestation of Hodgkin's lymphoma. He has been suffering from persistent high fever, asthenia, weight loss, and hepatosplenomegaly with no lymphadenopathy. The diagnosis of HLH secondary to infectious disease was initially worn. The patient received high-dose intravenous immunoglobulin with broad-spectrum antibiotics. However, his state got worse with the onset of dry cough and pleural effusion. Histopathologic examination of pleural fluid showed the presence of Reed-Sternberg cells. The outcome was favorable after treatment by corticosteroid and chemotherapy. Hodgkin's lymphoma revealed by HLH is a source of delayed diagnosis and should be borne in mind in children. PMID:25328742

Benmiloud, Sarra; Hbibi, Mohamed; Chaouki, Sana; Abourazzak, Sana; Hida, Moustapha

2014-01-01

211

Female reproductive potential after treatment for Hodgkin's disease  

SciTech Connect

The probability of maintaining ovarian function, becoming pregnant, and delivering a normal child is important to young women anticipating successful therapy for Hodgkin's disease. In this study, reproductive function was retrospectively examined in 103 women 40 years old or younger who had undergone treatment for Hodgkin's disease with total-lymphoid irradiation (TLI) alone, combination chemotherapy, or combined TLI and chemotherapy. Infertility was directly related to gonadal exposure to therapy and to age at treatment. Twenty women became pregnant after receiving total-nodal irradiation or combination chemotherapy or both. No fetal wastage occurred, and no birth defects were seen in the 24 infants born to these women. Even after intensive treatment programs, women successfully treated for Hodgkin's disease have become pregnant and delivered phenotypically normal children.

Horning, S.J.; Hoppe, R.T.; Kaplan, H.S.; Rosenberg, S.A.

1981-06-01

212

Non-Hodgkin's Malignant Lymphoma with Aggressive Development  

PubMed Central

Non-Hodgkin's malignant lymphoma is a hematologic malignant disease which usually responds to the polychemotherapy. We present a clinical case report of a 50 years old patient who develops an aggressive type of lymphoma. Patient develops a nodal Non-Hodgkin's malignant lymphoma who present at hospital admission as a huge tumor at the right side of the neck. Any type of treatment was a failure, the patient having a particularly aggressive form of lymphoma, resistant to all three chemotherapy regimens tested. Death occurs quickly, about one year after diagnosis and initiation of therapy. PMID:25553129

DANCIU, Cezara Elisabeta; HEROIU (CATALOIU), Adriana-Daniela; POPESCU, Cristian Radu

2014-01-01

213

Hodgkin's disease with hypercalcemia detected by thallium-201 scintigraphy  

SciTech Connect

A 53-yr-old man with hypercalcemia was referred after an unsuccessful operative attempt to find a parathyroid adenoma. Metabolic evaluation showed relatively suppressed levels of parathyroid hormone with an elevation of serum 1,25-dihydroxyvitamin D. Thallium-technetium dual isotope imaging revealed localized mediastinal thallium uptake. A vascular mediastinal lesion was then demonstrated by arteriography, with subsequent surgical removal of a mass that proved to be lymphocyte predominant Hodgkin's disease. This case is noteworthy for the finding of isolated lymphocyte predominant Hodgkin's disease in the chest, the association of elevated serum 1,25-dihydroxyvitamin D with hypercalcemia that resolved postoperatively, and the uptake of thallium by the tumor.

Linde, R.; Basso, L.

1987-01-01

214

Before it crumbles: Fulminant Hepatic Failure secondary to Hodgkin's Lymphoma  

PubMed Central

Fulminant hepatic failure (FHF) is a relatively rare manifestation of Hodgkin's lymphoma. Clinical features, laboratory findings, and imaging of the liver are usually inconclusive, and liver biopsy may be required for confirmation. We present a case of an FHF in a woman 1 week after the diagnosis of Hodgkin's lymphoma. Chemotherapy could not be instituted due to hepatic encephalopathy and other complications. Autopsy revealed diffuse infiltration of the liver parenchyma. This case illustrates the importance of early diagnosis and institution of chemotherapy, which may reverse the liver failure. PMID:25432655

Karmacharya, Paras; Bhandari, Naresh; Aryal, Madan R.; Pandit, Aashrayata A.; Pathak, Ranjan; Ghimire, Sailu; Shrestha, Pragya; Bhatt, Vijaya R.

2014-01-01

215

Production of a monoclonal antibody specific for Hodgkin and Sternberg-Reed cells of Hodgkin's disease and a subset of normal lymphoid cells  

Microsoft Academic Search

The origins of the neoplastic cells in Hodgkin's lymphoma1, the Hodgkin (H) and Sternberg-Reed(SR) cells, are still obscure, and these cells appear to carry no markers found on any population of normal cells2,3. However the recent establishment of permanent Hodgkin cell lines3,4 has led to the search for tumour-specific antigens and\\/or for membrane markers on H and SR cells which

Ulrich Schwab; Harald Stein; Johannes Gerdes; Hilmar Lemke; Hartmut Kirchner; Michael Schaadt; Volker Diehl

1982-01-01

216

Panobinostat and Everolimus in Treating Patients With Recurrent Multiple Myeloma, Non-Hodgkin Lymphoma, or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; B-cell Adult Acute Lymphoblastic Leukemia; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Primary Central Nervous System Non-Hodgkin Lymphoma; Recurrent Adult Acute Lymphoblastic Leukemia; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Refractory Multiple Myeloma; Splenic Marginal Zone Lymphoma; T-cell Adult Acute Lymphoblastic Leukemia; Waldenström Macroglobulinemia

2014-10-13

217

Automated parameter estimation of the Hodgkin-Huxley model using the differential evolution algorithm: application to neuromimetic analog integrated circuits.  

PubMed

We propose a new estimation method for the characterization of the Hodgkin-Huxley formalism. This method is an alternative technique to the classical estimation methods associated with voltage clamp measurements. It uses voltage clamp type recordings, but is based on the differential evolution algorithm. The parameters of an ionic channel are estimated simultaneously, such that the usual approximations of classical methods are avoided and all the parameters of the model, including the time constant, can be correctly optimized. In a second step, this new estimation technique is applied to the automated tuning of neuromimetic analog integrated circuits designed by our research group. We present a tuning example of a fast spiking neuron, which reproduces the frequency-current characteristics of the reference data, as well as the membrane voltage behavior. The final goal of this tuning is to interconnect neuromimetic chips as neural networks, with specific cellular properties, for future theoretical studies in neuroscience. PMID:21671785

Buhry, Laure; Grassia, Filippo; Giremus, Audrey; Grivel, Eric; Renaud, Sylvie; Saïghi, Sylvain

2011-10-01

218

Non-Hodgkin's Lymphoma by Immunohistochemistry.  

PubMed

Non Hodgkin's lymphomas (NHL) constitute a heterogeneous group of neoplasm of the lymphoid system. There are many histological subtype of NHL based on WHO classification of hematopoietic and lymphoid neoplasm. This cross-sectional study was carried out in the department of Pathology, Dhaka Medical College, Dhaka from January 2009 to December 2010 to observe the different subtypes of NHL using immunohistochemistry (IHC) with CD3. A total of 50 microscopically diagnosed case of NHL irrespective of age and sex were included in the study. The diagnostic morphologic criteria of each lymphoma subcategory were compiled and diagnosis was made. Mean age of the study subjects were 42.0±19.7 years with range 3-75 years and male female ratio was 1.8:1. Nodal NHL was 66% and extranodal cases were 34%. Maximum number of histolgic subtypes belonged to diffuse large B-cell lymphoma (DLBCL) and male was predominant in all histological subtypes, except peripheral T-cell lymphoma (PTCL). DLBCL was predominant in all B-cell NHL whereas PTCL was predominant in all T-cell NHL. The most childhood patients belonged to lymphoblastic lymphoma. Regarding cell lineage B-cell NHL was more common than T-cell NHL (88% vs. 12%), but high grade pattern was more predominant in T-cell type (83.3% vs. 65.9%). Among 50 study subjects histological (H & E) diagnosis reveals 46 cases as B-cell NHL and 4 as T-cell NHL but IHC confirms 6 cases as T-cell NHL. PMID:25725676

Akhter, A; Saleheen, M S; Hussain, M; Majid, N; Rahman, M R; Shermin, S; Rajib, R C; Huda, M M; Haque, N

2015-01-01

219

The Chinese Calendars  

NASA Astrophysics Data System (ADS)

In this article we try to answer the question how and why did Chinese ancient astronomy came into being and how did one lonesome and original calendar system on the very end of the world develop. At the beginning, Chinese people distinguished time of the year by the annual cycles of plants and animals, but soon began to determine seasons by observing celestial bodies. Early successful measuring of tropical year and synodic month made possible for Chinese people to issue first calendars very early. Spring and Autumn (Chunqiu) period (770 - 476 BC) brought forward first official calendars. Further improvement of calendars is due to the development of new astronomical instruments. Chinese calendars also originate from the metaphysical concepts of Qi, Yin-Yang and 5 elements. 5 elements were connected with Chinese 5 seasons of the year and this was the first form of solar calendar. Later, it developed into solar calendar with 10 months. In the next phase, Chinese calendar turned into lunisolar calendar which also has its evolution. Chinese people invented Calendar "with division by four" (the name of this calendar). They also added 24 solar terms to make calendar harmonize with natural cycles. Li Chunfeng rearranged intercalations and used month without main solar term and divided months into short and long months. Sexagesimal system of time measuring refers to the system of Chinese 10 Heavenly Stems and 12 Earthly Branches. Its purpose is to measure time and define years, months, days and hours.

Kostic, N.; Segan, S.

2009-09-01

220

Mandarin Chinese Yotam Feldman  

E-print Network

: Facts l Official language of l People's Republic of China (China) l Republic of China (Taiwan) l Singapore (but not a national language) l United Nations l Spoken also in l Malaysia l United States l ... l About one billion native speakers #12;Chinese Worldwide #12;Chinese: History l Part of the Sino

Dershowitz, Nachum

221

Chinese by Choice  

ERIC Educational Resources Information Center

A 2004 College Board survey revealed that school districts around America wanted to offer Chinese, but finding qualified teachers was a problem, says Selena Cantor, director of Chinese Language and Culture Initiatives for the College Board. So last year, a new College Board program brought guest teachers from China to school districts in 31…

Beem, Kate

2008-01-01

222

Ancient Chinese mathematics  

NSDL National Science Digital Library

This website contains a timeline and examples of early Chinese mathematics. Included are the Chinese version of the Pythagorean Theorem, a method of solving a system of linear equations, Pascals triangle, permutations and combinations, rule of false position, rule of three, magic squares, and puzzles. Other terms: fractions, algebra, negative numbers, scholars. (Includes 11 references)

Tommasina Tripodi,Joint Creator

2007-12-12

223

Chinese Foods; Teacher's Handbook.  

ERIC Educational Resources Information Center

Different styles of Chinese cooking, traditional food items, cooking utensils, serving techniques, and the nutritional value of Chinese cooking are described in this teaching guide. Lesson plans for the preparation of simple dishes are presented. Recipes, a shopping guide to San Francisco's Chinatown, a guide to sources of supplies, and a…

Huang, Joe, Ed.

224

ZU CHONGZHI CHINESE CALENDAR  

E-print Network

ZU CHONGZHI AND THE CHINESE CALENDAR REFORM OF 462 AD A GEM1506K PROJECT BY: LIM NYEK FONG ELAYNE BIOGRAPHY OF ZU CHONGZHI SECTION 2: HISTORICAL BACKGROUND ON THE NORTHERN AND SOUTHERN DYNASTIES SECTION 3: AN OVERVIEW OF CHINESE CALENDARS AND ASTRONOMY UP TO ZU CHONGZHI'S TIME SECTION 4: ASPECTS OF THE DAMING

Aslaksen, Helmer

225

Secondary cancer in a survivor of Hodgkin’s lymphoma: A case report and review of the literature  

PubMed Central

Hodgkin’s lymphoma (HL) is one of the most curable malignant diseases in adults. However, HL patients have a higher risk of developing second malignancies compared with the general population. The population of adult cancer survivors is growing, thus, the long-term effects of cancer treatment, including secondary cancer development, have become an increasingly important concern in the field of oncology. The current study presents the case of a female HL survivor who developed two secondary malignancies within 29 years of follow-up. Furthermore, a review of the literature was conducted, which focused on secondary breast and gastrointestinal cancers in HL survivors. PMID:25621073

LISIK-HABIB, MAJA; CZERNEK, URSZULA; D?BSKA-SZMICH, SYLWIA; KRAKOWSKA, MAGDALENA; KUBICKA-WO?KOWSKA, JOANNA; POTEMSKI, PIOTR

2015-01-01

226

Three cases demonstrating the role of gallium scanning in relapsing Hodgkin's disease and non-Hodgkin lymphoma  

SciTech Connect

Restaging of Hodgkin's disease and non-Hodgkin lymphoma for chemotherapy traditionally requires chest radiograph and abdominal computerized tomogram (CT) for routine follow-up examination. Although gallium scanning has had a poor record in the past, recent studies suggest that improved techniques have given this method high sensitivity. We present three cases in which gallium correctly staged lymphoma that had been missed or misinterpreted by chest radiographs and abdominal CT. Gallium imaging is useful in follow-up of lymphoma patients especially when the CT scan is difficult to interpret.

Zollars, L.E.; Nagel, J.S.; Tumeh, S.S.

1987-10-01

227

A case of Hodgkin’s lymphoma with severely impaired liver function treated successfully with gemcitabine followed by ABVD  

PubMed Central

Hodgkin’s lymphoma (HL) originates from clonal B cells and is the most common malignancy in the second decade of life. Liver involvement is uncommon at presentation in patients with HL and there is a paucity of data for treatment of patients with severely impaired liver function. We present an unusual case of HL with severe hepatic impairment, splenomegaly and multiple chromosomal abnormalities that was treated initially with gemcitabine and steroids. Once liver function tests improved, six cycles of Adriamycin, bleomycin, vinblastine, and dacarbazine were administered. The patient remains in remission at 3.5 years of follow-up. PMID:25848330

Chakraborty, Rajshekhar; Mukkamalla, Shiva Kumar Reddy; Gutzmore, Garfield; Chan, Hon Cheung

2015-01-01

228

Tree Biomass Estimation of Chinese fir (Cunninghamia lanceolata) Based on Bayesian Method  

PubMed Central

Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) is the most important conifer species for timber production with huge distribution area in southern China. Accurate estimation of biomass is required for accounting and monitoring Chinese forest carbon stocking. In the study, allometric equation was used to analyze tree biomass of Chinese fir. The common methods for estimating allometric model have taken the classical approach based on the frequency interpretation of probability. However, many different biotic and abiotic factors introduce variability in Chinese fir biomass model, suggesting that parameters of biomass model are better represented by probability distributions rather than fixed values as classical method. To deal with the problem, Bayesian method was used for estimating Chinese fir biomass model. In the Bayesian framework, two priors were introduced: non-informative priors and informative priors. For informative priors, 32 biomass equations of Chinese fir were collected from published literature in the paper. The parameter distributions from published literature were regarded as prior distributions in Bayesian model for estimating Chinese fir biomass. Therefore, the Bayesian method with informative priors was better than non-informative priors and classical method, which provides a reasonable method for estimating Chinese fir biomass. PMID:24278198

Zhang, Jianguo

2013-01-01

229

Tree biomass estimation of Chinese fir (Cunninghamia lanceolata) based on Bayesian method.  

PubMed

Chinese fir (Cunninghamia lanceolata (Lamb.) Hook.) is the most important conifer species for timber production with huge distribution area in southern China. Accurate estimation of biomass is required for accounting and monitoring Chinese forest carbon stocking. In the study, allometric equation W = a(D2H)b was used to analyze tree biomass of Chinese fir. The common methods for estimating allometric model have taken the classical approach based on the frequency interpretation of probability. However, many different biotic and abiotic factors introduce variability in Chinese fir biomass model, suggesting that parameters of biomass model are better represented by probability distributions rather than fixed values as classical method. To deal with the problem, Bayesian method was used for estimating Chinese fir biomass model. In the Bayesian framework, two priors were introduced: non-informative priors and informative priors. For informative priors, 32 biomass equations of Chinese fir were collected from published literature in the paper. The parameter distributions from published literature were regarded as prior distributions in Bayesian model for estimating Chinese fir biomass. Therefore, the Bayesian method with informative priors was better than non-informative priors and classical method, which provides a reasonable method for estimating Chinese fir biomass. PMID:24278198

Zhang, Xiongqing; Duan, Aiguo; Zhang, Jianguo

2013-01-01

230

Season of birth and risk of Hodgkin and non-Hodgkin lymphoma.  

PubMed

Infectious etiologies have been hypothesized for Hodgkin and non-Hodgkin lymphoma (HL and NHL) in early life, but findings to date for specific lymphomas and periods of susceptibility are conflicting. We conducted the first national cohort study to examine whether season of birth, a proxy for infectious exposures in the first few months of life, is associated with HL or NHL in childhood through young adulthood. A total of 3,571,574 persons born in Sweden in 1973-2008 were followed up through 2009 to examine the association between season of birth and incidence of HL (943 cases) or NHL (936 cases). We found a sinusoidal pattern in NHL risk by season of birth (p?=?0.04), with peak risk occurring among birthdates in April. Relative to persons born in fall (September-November), odds ratios for NHL by season of birth were 1.25 [95% confidence interval (CI), 1.04-1.50; p?=?0.02] for spring (March-May), 1.22 (95% CI, 1.01-1.48; p?=?0.04) for summer (June-August) and 1.11 (95% CI, 0.91-1.35; p?=?0.29) for winter (December-February). These findings did not vary by sex, age at diagnosis or major subtypes. In contrast, there was no seasonal association between birthdate and risk of HL (p?=?0.78). In this large cohort study, birth in spring or summer was associated with increased risk of NHL (but not HL) in childhood through young adulthood, possibly related to immunologic effects of delayed infectious exposures compared with fall or winter birth. These findings suggest that immunologic responses in early infancy may play an important role in the development of NHL. PMID:24752499

Crump, Casey; Sundquist, Jan; Sieh, Weiva; Winkleby, Marilyn A; Sundquist, Kristina

2014-12-01

231

Four Proofs of the Converse of the Chinese Remainder Theorem  

ERIC Educational Resources Information Center

Four proofs, designed for classroom use in varying levels of courses on abstract algebra, are given for the converse of the classical Chinese Remainder Theorem over the integers. In other words, it is proved that if m and n are integers greater than 1 such that the abelian groups [double-struck z][subscript m] [direct sum] [double-struck…

Dobbs, D. E.

2008-01-01

232

Learning from Asian philosophy: Chinese versus Western ethics  

Microsoft Academic Search

Over the years I have pursued an interest in classical Asian philosophies that began when, as an undergraduate at the University of Chicago, I was one of three students in a seminar on Chinese philosophy offered by the great Confucian scholar H. G. Creel. It seemed to me, and has continued to seem to me, that much Asian philosophy raised

Joel J. Kupperman

1999-01-01

233

Modern Chinese: History and Sociolinguistics.  

ERIC Educational Resources Information Center

This book presents a comprehensive and up-to-date account of the development of modern Chinese from the late 19th century up to the 1990s, concentrating on three major aspects: modern spoken Chinese, modern written Chinese, and the modern Chinese writing system. It describes and analyzes in detail, from historical and sociolinguistic perspectives,…

Chen, Ping

234

Thyroid dysfunction after radiotherapy in children with Hodgkin's disease  

Microsoft Academic Search

Thyroid function was measured in 119 children, 16 years of age or less, after radiotherapy (XRT) for Hodgkin's disease. Thyroid abnormalities developed in 4 of 24 children (17%) who received 2600 rad or less, and in 74 of 95 children (78%) who received greater than 2600 rad to the cervical area, including the thyroid. The abnormality in all but three

Louis S. Constine; Sarah S. Donaldson; I. Ross McDougall; Richard S. Cox; Michael P. Link; Henry S. Kaplan

1984-01-01

235

Presternal soft tissue calcifications following mediastinal radiotherapy for Hodgkin's disease  

SciTech Connect

A patient is described in whom dense calcifications developed in the presternal soft tissues of the chest four years after mediastinal radiotherapy. This is believed to represent dystrophic calcification in previously normal but incidentally radiated tissues following standard dose radiotherapy to the mediastinum for stage IIA Hodgkin's disease.

Vainright, J.R.; Diaconis, J.N.; Haney, P.J.

1987-01-01

236

Results of radiotherapy for stage I and II Hodgkin's disease  

SciTech Connect

Fifty-six patients with pathologically staged I and II (A and B) Hodgkin's disease were treated with radiation therapy. Three-year relapse-free survival, total survival, and complications were analyzed. Chemotherapy was valuable as rescue treatment and as part of the initial treatment in patients with stage IIB disease. Complications were minimal.

Lowery, G.S.; Ferree, C.R.; Raben, M.

1982-06-01

237

Lymphomatoid papulosis and Hodgkin's disease: Are they related?  

Microsoft Academic Search

Two different characteristic types of lymphomatoid papulosis (type A and type B) can be histologically distinguished, that represent the ends of a spectrum. In the present report, two patients are described. One patient with both lymphomatoid papulosis type A and type B lesions for more than 25 years developed Hodgkin's disease (nodular sclerosing type) in the para-aortic and para-iliac lymph

R. Willemze; E. Scheffer; W. A. Van Vloten; C. J. L. M. Meijer

1983-01-01

238

Acute toxoplasmosis-etiological factor for development of Hodgkin's lymphoma?  

PubMed

The case of an HIV-positive man treated for acute toxoplasmosis with no traces of malignancy is reported. A second lymph node extirpation was performed after 5 months, which identified the presence of Hodgkin and Reed-Sternberg (HRS) cells. This case suggests that toxoplasmosis may cause changes in the regulation of surrounding cells and induce neoplastic proliferation. PMID:23848412

Snopkova, Svatava; Pohanka, Miroslav; Polak, Pavel; Havlickova, Katerina; Jarkovsky, Ji?i; Moulis, Mojmir; Stroblova, Hana; Husa, Petr

2013-12-01

239

Pediatric Hodgkin's disease: Treatment in the late 1990s  

Microsoft Academic Search

Summary Background: For two decades now combined chemo-radio- therapy has been preferred in most of the studies on childhood Hodgkin's disease (HD), because combined modality is the precondition for (1) reducing the radiation dose, (2) reducing the radiation fields, (3) shortening chemotherapy, (4) omitting splenectomy and laparotomy, and thus, for optimizing the ben- efit\\/risk ratio between cure rates and late

G. Schellong

240

Comparison of staging methods for Hodgkin's disease in children  

SciTech Connect

Potential long-term complications of radiotherapy and chemotherapy in the pediatric patient with Hodgkin's disease necessitate accurate staging. To determine the accuracy of abdominal computed tomography (CT) and gallium citrate Ga 67 scans in staging Hodgkin's disease, we reviewed the charts of all children with Hodgkin's disease seen at Childrens Hospital of Los Angeles from 1975 to 1985. Patients with pathologically proved stage IV disease (ie, bone marrow involvement) and those who only underwent staging laparotomy were excluded. A total of 40 children underwent staging by laparotomy and staging by abdominal CT and/or /sup 67/Ga scan. The CT and /sup 67/Ga scans were reviewed by radiologists in a blinded manner and compared with the results of a formal staging laparotomy. Of the 38 patients whose disease was staged with /sup 67/Ga scan, disease in ten was understaged and in four overstaged, for a 37% incorrect staging rate. Of the 14 patients whose disease was staged by CT scan, disease in three was understaged and in one overstaged, for a 29% incorrect staging rate. In view of the inaccuracy of noninvasive studies and the impact of incorrect staging on treatment, we recommend that a staging laparotomy be performed in all children with Hodgkin's disease who are not proved to have stage IV disease.

Lally, K.P.; Arnstein, M.; Siegel, S.; Miller, J.H.; Gilsanz, V.; Ettinger, L.; Atkinson, J.B.

1986-10-01

241

Novel Drug Effectively Shrinks Tumors in Hodgkin Lymphoma  

Cancer.gov

An investigational drug composed of a monoclonal antibody linked to a potent chemotherapy agent led to complete or substantial tumor shrinkage in nearly 40 percent of patients with Hodgkin lymphoma in a phase I clinical trial, researchers reported November 4, 2010, in the New England Journal of Medicine.

242

A difficult diagnosis of Hodgkin lymphoma due to immune thrombocytopenia  

PubMed Central

Key Clinical Message We report a rare clinical presentation of childhood Hodgkin lymphoma with immune thrombocytopenia. Diagnostic biopsy of the abdominal mass was performed after administration of intravenous immunoglobulins, steroids, and platelet transfusion. Concomitant thrombocytopenia complicated the whole diagnosis work up and the initial management of neoplasia.

Marino, Silvia; Di Cataldo, Andrea; Magro, Gaetano; D'Amico, Salvatore; La Spina, Milena; Di Benedetto, Vincenzo; Meli, Mariaclaudia; Moscheo, Carla; Russo, Giovanna

2015-01-01

243

Nucleoli and AgNORs in Hodgkin's disease.  

PubMed Central

AIM: To evaluate the morphofunctional characteristics of lymph node cells from patients with Hodgkin's disease by measuring silver stained nucleolar organiser regions (AgNORs). METHODS: Nucleoli in Hodgkin's and Reed-Sternberg (HRS) cells, lymphocytes and prolymphocytes were investigated in cytological smears and histological sections of lymph nodes from 32 patients with Hodgkin's disease, and from 34 patients with reactive lymphadenopathy. According to the Rye histological classification of Hodgkin's disease, three cases were the lymphocyte predominant (LP) type, 14 the nodular sclerosing (NS) type, and 15 the mixed cellularity (MC) type. The investigation was done before treatment, by means of a one step silver staining method. In each case, 50 to 100 HRS cells, lymphocytes, and prolymphocytes were evaluated to determine the mean numbers of nucleoli and AgNORs per nucleus. The nonparametric Wilcoxon Mann-Whitney test was used to compare the groups. RESULTS: The mean numbers of nucleoli and AgNORs were higher in lymphocytes and prolymphocytes compared with those from reactive lymph nodes used as controls. Numbers of nucleoli and AgNORs were higher (not significant) in the NS type of Hodgkin's disease than in the MC type. There was a significant increase in numbers of nucleoli in HRS cells, and their AgNOR counts were increased. The greatest number of nucleoli in HRS cells was found in the NS type. Furthermore, the nucleolar activity of HRS cells was greater in the NS type compared with the MC type (50.2 (SEM 3.9) v 37.7 (2.9) AgNORs per nucleus (p = 0.025)). Comparative analysis of cytological and histological samples showed that the AgNOR score was significantly higher in touch imprints than in tissue sections with tumours of the same histological type. CONCLUSIONS: Assessment of cell activity in Hodgkin's disease patients by silver staining is more convenient and informative in lymph node imprints than in histological sections. The highest expression of interphase ribosomal RNA cistrons found in NS HRS cells is probably explained by their high proliferative activity and elevated production of transforming growth factor 1 which is known to be the most potent cytokine present in the NS subtype of Hodgkin's disease. Images PMID:9292150

Mamaev, N. N.; Medvedeva, N. V.; Shust, V. F.; Markochev, A. B.; Pasternak, N. D.

1997-01-01

244

Association between simian virus 40 and non-Hodgkin lymphoma  

NASA Technical Reports Server (NTRS)

BACKGROUND: Non-Hodgkin lymphoma has increased in frequency over the past 30 years, and is a common cancer in HIV-1-infected patients. Although no definite risk factors have emerged, a viral cause has been postulated. Polyomaviruses are known to infect human beings and to induce tumours in laboratory animals. We aimed to identify which one of the three polyomaviruses able to infect human beings (simian virus 40 [SV40], JC virus, and BK virus) was associated with non-Hodgkin lymphoma. METHODS: We analysed systemic non-Hodgkin lymphoma from 76 HIV-1-infected and 78 HIV-1-uninfected patients, and non-malignant lymphoid samples from 79 HIV-1-positive and 107 HIV-1-negative patients without tumours; 54 colon and breast carcinoma samples served as cancer controls. We used PCR followed by Southern blot hybridisation and DNA sequence analysis to detect DNAs of polyomaviruses and herpesviruses. FINDINGS: Polyomavirus T antigen sequences, all of which were SV40-specific, were detected in 64 (42%) of 154 non-Hodgkin lymphomas, none of 186 non-malignant lymphoid samples, and none of 54 control cancers. This difference was similar for HIV-1-infected patients and HIV-1-uninfected patients alike. Few tumours were positive for both SV40 and Epstein-Barr virus. Human herpesvirus type 8 was not detected. SV40 sequences were found most frequently in diffuse large B-cell and follicular-type lymphomas. INTERPRETATION: SV40 is significantly associated with some types of non-Hodgkin lymphoma. These results add lymphomas to the types of human cancers associated with SV40.

Vilchez, Regis A.; Madden, Charles R.; Kozinetz, Claudia A.; Halvorson, Steven J.; White, Zoe S.; Jorgensen, Jeffrey L.; Finch, Chris J.; Butel, Janet S.

2002-01-01

245

Radiation-induced malignant tumors of bone in patients with Hodgkin's disease  

SciTech Connect

Sixteen cases of radiogenic malignant bone tumors which developed in patients 4 to 31 y after they had received radiation therapy for Hodgkin's disease are compared with 70 similar cases occurring after radiation exposure for other causes. No significant differences in age at irradiation, latent period, histology of tumors or radiographic characteristics were found between the Hodgkin's cases and those of the comparison series. Fourteen of the 16 tumors in Hodgkin's patients, or 87%, were diagnosed in the 15-y period between 1971 and 1985 in contrast to only 34% of the larger non-Hodgkin's series. This difference appears significant and is associated with a doubling of the proportion of Hodgkin's patients who are now living past the minimum latent period for such tumors. The median dose in the Hodgkin's patients, 4000 cGy, is less than the 5100-cGy median in the other patients, and the range and protraction of the total doses are much less. In Hodgkin's patients who have received total nodal irradiation, the volume of osseous tissue which is exposed may reach 25% of the total in the body. This is much greater than in most other treatment plans. Six of the Hodgkin's patients received chemotherapy within a few months of irradiation; only three of 70 non-Hodgkin's patients did so. All of the last factors may have modified the risk of radiation carcinogenesis in the Hodgkin's patients but the data are not yet adequate for quantitation of the effect.

Woodard, H.Q.; Huvos, A.G.; Smith, J.

1988-10-01

246

Toxicity of the Chinese herb mu tong (Aristolochia manshuriensis). What history tells us.  

PubMed

Plant sources of some traditional Chinese herbs may have changed over time. History records of herbal toxicity should be viewed critically when different plants might have been used under the same name in earlier eras. The current main source of the Chinese herb Mu Tong is Aristolochia manshuriensis. Examination of classical Chinese herbal literature revealed that until the mid 17th century the original source plants of Mu Tong had been several Akebia species. From the 17th century until the early 20th century Clematis species were the main source of Mu Tong. A manshuriensis has only been widely used since the 1950s. Renal failure due to ingestion of large doses of A. manshuriensis has been reported in China and other countries while no such toxicity has been recorded in traditional Chinese herbal texts. Documentation of traditional Chinese herbal literature should help to ensure the safe use of Chinese herbs. PMID:12503251

Zhu, You-Ping

2002-01-01

247

Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With HIV-Associated Non-Hodgkin or Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; AIDS-related Diffuse Large Cell Lymphoma; AIDS-related Diffuse Mixed Cell Lymphoma; AIDS-related Diffuse Small Cleaved Cell Lymphoma; AIDS-related Immunoblastic Large Cell Lymphoma; AIDS-related Lymphoblastic Lymphoma; AIDS-related Peripheral/Systemic Lymphoma; AIDS-related Small Noncleaved Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; HIV-associated Hodgkin Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I AIDS-related Lymphoma; Stage II AIDS-related Lymphoma; Stage III AIDS-related Lymphoma; Stage IV AIDS-related Lymphoma; T-cell Large Granular Lymphocyte Leukemia; Testicular Lymphoma; Waldenström Macroglobulinemia

2014-12-15

248

The ancient Chinese notes on hydrogeology  

NASA Astrophysics Data System (ADS)

The ancient Chinese notes on hydrogeology are summarized and interpreted, along with records of some related matters, like groundwater exploration and utilization, karst springs, water circulation, water conservation and saline-land transformation, mine drainage, and environmental hydrogeology. The report focuses only on the earliest recorded notes, mostly up until the Han Dynasty (206 BC - AD 25). Besides the references cited, the discussion in this report is based mainly on archaeological material, the preserved written classic literature, and some assumptions and/or conclusions that have been handed down in legends to later ages. Although most material relates to ancient China, the lessons learned may have practical significance worldwide. Compared to other contemporary parts of the world, ancient China, without doubt, took the lead in the field of groundwater hydrology. The great achievements and experience of the Chinese ancestors should provide motivation and inspiration for hydrogeologists to carry out their scientific research and exploration passionately and actively.

Zhou, Yu; Zwahlen, François; Wang, Yanxin

2011-08-01

249

[Factors involved in host-pathogen interaction for the risk of Hodgkin lymphoma induced by Epstein Barr virus].  

PubMed

Hodgkin lymphoma (HL) is a neoplasm characterized by malignant cells called Reed Sternberg and Hodgkin's cells in the lymphatic system. Such cells comprise 1% of the tumor while the remainder is made up of lymphocytes, histiocytes, eosinophils and plasma non-neoplastic cells. The annual global incidence of HL is 3-10/100,000 inhabitants and is most commonly found in young adults. The mechanism by which cell transformation is accomplished is not entirely clear; however, some evidences suggest that oncogenic viruses like the Epstein Barr virus (EBV) may have a high impact on the pathogenesis of lymphoproliferation. Genetic and environmental factors could be involved, since it has been found a high incidence of HL among members of the same family. In Mexico, there have been studies to determine the prevalence of EBV in patients with HL and found the presence of this virus in up to 64.2% of the cases. EBV has been detected in the Reed Sternberg cells and Hodgkin cells in 50% of cases of classical HL. There is not a satisfactory explanation for this, but it has been proposed that geographic and immunological variabilities play a role in the positivity of EBV in HL. However, despite recent advances in the field, there is insufficient evidence to show a clear association between host factors, environment and pathogens, and the risk of lymphoproliferation leading to the development of HL. This review aims to give an overview about the risk factors that influence the interaction of host, pathogens and environment in the etiology of HL. PMID:24354244

Torres Espíndola, Luz María; Arellano Galindo, José; Velazquez Cruz, Rafael; Castillejos López, Manuel de Jesús

2013-09-01

250

Hodgkin and Reed-Sternberg Cells in Lymphocyte Predominant Hodgkin Disease Represent Clonal Populations of Germinal Center-Derived Tumor B Cells  

Microsoft Academic Search

Among the four subtypes of Hodgkin disease (HD), lymphocyte-predominant (LP) HD is now generally considered as a separate entity. The B cell nature of the typical Hodgkin and Reed-Sternberg (HRS) cells and their variants (L and H, lymphocytic and histiocytic cells) in LP HD has long been suspected, but the question of whether these cells represent a true tumor clone

Andreas Braeuninger; Ralf Kuppers; John G. Strickler; Hans-Heinrich Wacker; Klaus Rajewsky; Martin-Leo Hansmann

1997-01-01

251

Confucian global leadership in Chinese tradition: classical and contemporary  

Microsoft Academic Search

Purpose – This paper aims to inquire and argue for a renovated model of Confucian political leadership as a way of political governance rooted in a philosophy of humanity and its potential for development. Design\\/methodology\\/approach – The paper is primarily critical and constructive through philosophical analysis and synthesis of ideas and insights into nature of man and political leadership in

Chung-ying Cheng

2011-01-01

252

FALL 2002 PHILOSOPHY ELECTIVES PL 193 01 Chinese Classical Philosophy  

E-print Network

PHILOSOPHYAND FILM NOIR MW 3* ThomasHibbs PL45501 1652 KIERKEGAARD/NIETZSCHE MW F 2 StuartMartin PL50001 9048 Anderson, S.J. PL59301 2953 PHILOSOPHYOF SCIENCE T4 30-6 30 Patrick Byrne PL59501 4196 KANT'SCRITIQUE MW 3

Huang, Jianyu

253

AMATH 882 Assignment 5 Due Tuesday, April 2 1. In the problem you will compare the bifurcation structure for the Hodgkin  

E-print Network

structure for the Hodgkin Huxley model and the two dimensional reduction of the Hodgkin Huxley equations due for the Hodgkin Huxley model using the constant applied current as the bifurcation parameter. One should show

Campbell, Sue Ann

254

Chinese restaurant syndrome  

MedlinePLUS

... people have after eating Chinese food. A food additive called monosodium glutamate (MSG) has been blamed, but ... that some people are particularly sensitive to food additives, and MSG is chemically similar to one of ...

255

Traditional Chinese Biotechnology  

NASA Astrophysics Data System (ADS)

The earliest industrial biotechnology originated in ancient China and developed into a vibrant industry in traditional Chinese liquor, rice wine, soy sauce, and vinegar. It is now a significant component of the Chinese economy valued annually at about 150 billion RMB. Although the production methods had existed and remained basically unchanged for centuries, modern developments in biotechnology and related fields in the last decades have greatly impacted on these industries and led to numerous technological innovations. In this chapter, the main biochemical processes and related technological innovations in traditional Chinese biotechnology are illustrated with recent advances in functional microbiology, microbial ecology, solid-state fermentation, enzymology, chemistry of impact flavor compounds, and improvements made to relevant traditional industrial facilities. Recent biotechnological advances in making Chinese liquor, rice wine, soy sauce, and vinegar are reviewed.

Xu, Yan; Wang, Dong; Fan, Wen Lai; Mu, Xiao Qing; Chen, Jian

256

Chinese Business Law Postgraduate  

E-print Network

) · Consumer protection · Due diligence · Product quality legislation · Foreign trade regulations · Entry modes law 4 2 · Customs law & Regulations · Foreign trade law Chinese environmental law 3 2 · Environmental · Financial law · Foreign exchange regulation · Government procurement law · Price fixing regulations Courses

Einmahl, Uwe

257

Chinese Tallow: Invading the Southeastern Coastal Plain  

USGS Publications Warehouse

Chinese tallow is an ornamental tree with colorful autumn foliage that can survive full sunlight and shade, flooding, drought, and in some cases fire. To horticulturists this kind of tree sounds like a dream, but to ecologists, land managers, and land owners this kind of tree can be a nightmare, especially when it invades an area and takes over native vegetation. Chinese tallow (Triadica sebifera), a nonnative tree from China, is currently transforming the southeastern Coastal Plain. Over the last 30 years, Chinese tallow has become a common tree in old fields and bottomland swamps of coastal Louisiana. Several studies at the U.S. Geological Survey's National Wetlands Research Center (NWRC), Lafayette, Louisiana, are aimed at understanding the factors that contribute to Chinese tallow growth, spread, and management. When tallow invades, it eventually monopolizes an area, creating a forest without native animal or plant species. This tree exhibits classic traits of most nonnative invaders: it is attractive so people want to distribute it, it has incredible resiliency, it grows quickly and in a variety of soils, and it is resistant to pests. In the coastal prairie of Louisiana and Texas, Chinese tallow can grow up to 30 feet and shade out native sun-loving prairie species. The disappearing of prairie species is troublesome because less than 1% of original coastal prairie remains, and in Louisiana, less than 500 of the original 2.2 million acres still exist. Tallow reproduces and grows quickly and can cause large-scale ecosystem modification (fig. 1). For example, when it completely replaces native vegetation, it has a negative effect on birds by degrading the habitat. Besides shading out grasses that cattle like to eat, it can also be potentially harmful to humans and animals because of its berries (fig. 2) and plant sap that contain toxins. There is some concern its leaves may shed toxins that change the soil chemistry and make it difficult for other plants to grow.

U.S. Geological Survey

2000-01-01

258

Risk of second breast cancer in female Hodgkin’s lymphoma survivors: a meta-analysis  

PubMed Central

Background Women treated for Hodgkin’s lymphoma (HL) have an elevated risk of developing second breast cancer (SBC) compared with the general population. We planned this meta-analysis to quantify the long-term risk of SBC and analyze the contributing risk factors among HL survivors. Methods According to predefined selection criteria, literature search identified 34 studies that were included in the analyses. Results After eliminating overlapping or duplicate data, 957 incidences of SBC were encountered in 24,505 females with HL over a median follow-up of 14.9?years. The medians: age at the diagnosis of HL, age at diagnosis of SBC, and latency since HL treatment to the development of SBC were 23.7, 35.0, and 17.7?years, respectively. The pooled relative risk (RR) of SBC was 8.23 (95% CI, 5.43-12.47, I2?=?96%), with a median absolute excess rate of 22.9 per 10,000 person-years. The RR was found inversely related to age at diagnosis of HL with the highest rate (68.7; [95%CI, 28.08-168.11], I2?=?79%), occurred in young patients (? 15?years old), where the RR in older women (? 40?years old) was not significant (0.55; [95% CI, 0.09-3.52]). Analysis of RR by 5-year increments since the treatment of HL showed that the risk was highest after 15–19?years of latency (13.87; [95% CI, 7.91-24.30], I2?=?89%). Analysis of the effect of treatment modalities showed that the RR rates were (4.70; [95% CI, 3.28-6.75], I2?=?74%), (5.65; [95%CI, 2.94-10.88], I2?=?91%), and (1.19; [95% CI, 0.50-2.82], I2?=?65%), for radiotherapy (RT) only, combined RT and chemotherapy (CT), and CT only, respectively. To investigate the demonstrated heterogeneity, meta-regression analysis was performed when feasible. In most such analyses, the natural logarithm of RR was inversely associated with age at HL diagnosis. Conclusions We conclude that, the current meta-analysis provided the most recent comprehensive estimate of the risk of SBC in a broad-range of HL survivors. Younger age at diagnosis proved to be a dominant risk factor. The obtained results would serve providing breast cancer screening recommendations for HL survivors. PMID:22639888

2012-01-01

259

Increased risk of lung cancer, non-Hodgkin's lymphoma, and leukemia following Hodgkin's disease  

SciTech Connect

The risk of second cancers (SCs) was assessed in 744 patients with Hodgkin's disease (HD) admitted to The Netherlands Cancer Institute from 1966 to 1983. Sixty-nine SCs were observed one month or more after start of first treatment. These included 14 cases of lung cancer, nine cases of non-Hodgkin's lymphoma (NHL), 16 cases of leukemia, and six cases of the myelodysplastic syndrome (MDS). The median interval between the diagnosis of HD and that of second lung cancer, NHL, and leukemia was 8.1, 13.3, and 5.7 years, respectively. The overall relative risks (RR) (observed/expected (O/E) ratios) of developing lung cancer, NHL, and leukemia were 4.9 (95% confidence limit (CL), 2.7 to 8.2), 31.0 (95% CL, 14.2 to 58.9) and 45.7 (95% CL, 26.1 to 74.2), respectively. At 15 years the cumulative risk of developing an SC amounted to 20.6% +/- 2.9%. The 15-year estimates of lung cancer, NHL, and leukemia were 6.2% +/- 1.9%, 5.9% +/- 2.1% and 6.3% +/- 1.7%, respectively. Increased lung cancer risk following HD has not frequently been clearly demonstrated before; that we were able to demonstrate such risk may be due to the completeness of follow-up over long periods that could be achieved in this study. Excess lung cancer risk was only noted in treatment regimens with radiotherapy (RT); also, all lung cancers arose in irradiation fields. Excess risk of leukemia was only found in treatment regimens involving chemotherapy (CT). For NHL, combined modality treatment was shown to be the most important risk factor. Risk of lung cancer and NHL increased with time since diagnosis. A time-dependent covariate analysis (Cox model) performed on leukemia and MDS showed an increasing risk with intensity of CT, age (greater than 40 years), and a splenectomy.

van Leeuwen, F.E.; Somers, R.; Taal, B.G.; van Heerde, P.; Coster, B.; Dozeman, T.; Huisman, S.J.; Hart, A.A. (Netherlands Cancer Institute, Amsterdam)

1989-08-01

260

Stage IV and age over 45 years are the only prognostic factors of the International Prognostic Score for the outcome of advanced Hodgkin lymphoma in the Spanish Hodgkin Lymphoma Study Group series.  

PubMed

The International Prognostic Score (IPS) is the most widely used system to date for identifying risk groups for the outcome of patients with advanced Hodgkin lymphoma, although important limitations have been recognized. We analyzed the value of the IPS in a series of 311 patients with advanced classical Hodgkin lymphoma (cHL) (Ann Arbor stage III, IV or stage II with B symptoms and/or bulky masses) treated with first-line chemotherapy including adriamycin (adriamycin, bleomycin, vinblastine, dacarbazine [ABVD] or equivalent variants). In univariate and multivariate analyses, stage IV disease and age ? 45 years were the only factors with independent predictive significance for overall survival (OS) (p = 0.002 and p < 0.001, respectively). Stage IV was still significant for freedom from progression (FFP) (p = 0.001) and age ? 45 years was borderline significant (p = 0.058). IPS separates prognostic groups, as in the original publication, but this is mainly due to the high statistical significance of stage IV and age ? 45 years. Moreover, the combination of these two factors enables a simpler system to be constructed that separates groups with different FFP and OS. In conclusion, in our series, stage IV and age ? 45 years are the key prognostic factors for the outcome of advanced cHL. PMID:22185637

Guisado-Vasco, Pablo; Arranz-Saez, Reyes; Canales, Miguel; Cánovas, Araceli; Garcia-Laraña, José; García-Sanz, Ramón; Lopez, Andrés; López, José Luis; Llanos, Marta; Moraleda, José Maria; Rodriguez, José; Rayón, Consuelo; Sabin, Pilar; Salar, Antonio; Marín-Niebla, Ana; Morente, Manuel; Sánchez-Godoy, Pedro; Tomás, José Francisco; Muriel, Alfonso; Abraira, Victor; Piris, Miguel A; Garcia, Juán F; Montalban, Carlos

2012-05-01

261

Nodular lymphocyte predominant Hodgkin lymphoma behaves as a distinct clinical entity with good outcome: evidence from 14-year follow-up in the West of Scotland Cancer Network.  

PubMed

Clinically and biologically, nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has much more in common with germinal-center derived B-cell non-Hodgkin lymphoma (NHL) than with classical Hodgkin lymphoma (cHL). Management of NLPHL remains controversial. In a 14-year multicenter series, 69 cases were analyzed, and the median follow-up was 53 months (range 11-165.) B-symptoms were present in only 4.3% of patients, and 81.1% of patients had stage I/II disease. Treatment was with radiotherapy (53.6%), chemotherapy (21.7%), combined modality (17.4%), and observation (7.2%). In all, 10.1% of patients relapsed and 2.9% of patients developed high-grade transformation to DLBCL. All relapses and transformations were salvageable. No patient died of their disease. The 5-year relapse-free survival was 92%, transformation-free survival 98.4%, and overall survival 100%. We conclude that NLPHL behaves as a distinct clinical entity, often presenting at an early stage without risk factors. It has an excellent outcome. It may be possible, in early-stage disease, to reduce the intensity of therapy in NLPHL, to single-modality radiotherapy, without affecting OS. PMID:21663507

Farrell, Katrina; McKay, Pamela; Leach, Mike

2011-10-01

262

Dose Monitoring of Busulfan and Combination Chemotherapy in Hodgkin or Non-Hodgkin Lymphoma Undergoing Stem Cell Transplant  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Childhood Burkitt Lymphoma; Childhood Diffuse Large Cell Lymphoma; Childhood Grade III Lymphomatoid Granulomatosis; Childhood Immunoblastic Large Cell Lymphoma; Childhood Nasal Type Extranodal NK/T-cell Lymphoma; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Contiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Contiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Grade 3 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Contiguous Stage II Marginal Zone Lymphoma; Contiguous Stage II Small Lymphocytic Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Mixed Cell Lymphoma; Noncontiguous Stage II Adult Diffuse Small Cleaved Cell Lymphoma; Noncontiguous Stage II Adult Immunoblastic Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Grade 3 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Noncontiguous Stage II Marginal Zone Lymphoma; Noncontiguous Stage II Small Lymphocytic Lymphoma; Noncutaneous Extranodal Lymphoma; Peripheral T-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Childhood Anaplastic Large Cell Lymphoma; Recurrent Childhood Grade III Lymphomatoid Granulomatosis; Recurrent Childhood Large Cell Lymphoma; Recurrent Childhood Lymphoblastic Lymphoma; Recurrent Childhood Small Noncleaved Cell Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Recurrent/Refractory Childhood Hodgkin Lymphoma; Refractory Hairy Cell Leukemia; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Diffuse Mixed Cell Lymphoma; Stage I Adult Diffuse Small Cleaved Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Immunoblastic Large Cell Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Adult T-cell Leukemia/Lymphoma; Stage I Childhood Anaplastic Large Cell Lymphoma; Stage I Childhood Hodgkin Lymphoma; Stage I Childhood Large Cell Lymphoma; Stage I Childhood Lymphoblastic Lymphoma; Stage I Childhood Small Noncleaved Cell Lymphoma; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Grade 3 Follicular Lymphoma; Stage I Mantle Cell Lymphoma; Stage I Marginal Zone Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Adult Hodgkin Lymphoma; Stage II Adult T-cell Leukemia/Lymphoma; Stage II Childhood Anaplastic Large Cell Lymphoma; Stage II Childhood Hodgkin Lymphoma; Stage II Childhood Large Cell Lymphoma; Stage

2015-01-29

263

Recent Advances in the Pathobiology of Hodgkin's Lymphoma: Potential Impact on Diagnostic, Predictive, and Therapeutic Strategies  

PubMed Central

From its first description by Thomas Hodgkin in 1832, Hodgkin's disease, now called Hodgkin's lymphoma, has continued to be a fascinating neoplasm even to this day. In this review, historical aspects, epidemiology, diagnosis, tumor biology, new observations related to host-microenvironment interactions, gene copy number variation, and gene expression profiling in this complex neoplasm are described, with an exploration of chemoresistance mechanisms and potential novel therapies for refractory disease. PMID:21318045

Banerjee, Diponkar

2011-01-01

264

Sideroblastic anemia as a preleukemic event in patients treated for Hodgkin's disease  

SciTech Connect

Sideroblastic anemia after treatment for Hodgkin's disease was seen in two patients 3 years after completion of radiation therapy and chemotherapy. This was followed in both by the development of myelomonoblastic leukemia. No evidence of recurrent Hodgkin's disease was present in either patient. Our observation suggests that development of sideroblastic anemia in patients previously treated for Hodgkin's disease is probably secondary to the treatment and is a preleukemic event.

Kitahara, M.; Cosgriff, T.M.; Eyre, H.J.

1980-05-01

265

Histological expression of angiogenic factors: VEGF, PDGFR ?, and HIF-1 ? in Hodgkin lymphoma  

Microsoft Academic Search

Angiogenesis is a prerequisite for solid tumor growth, but there is relatively limited data regarding Hodgkin lymphoma. The purpose of this study was to examine the immunohistochemical expression of angiogenic and proliferation markers in Hodgkin biopsies in relation to clinical parameters.Immunostaining was performed on 65 Hodgkin biopsies with vascular endothelial growth factor (VEGF), hypoxia inducible factor-1 alpha (HIF-1?), platelet-derived growth

Freda H. Passam; Michael G. Alexandrakis; Maria Kafousi; Marianthi Fotinou; Katerina Darivianaki; George Tsirakis; Paraskevi A. Roussou; Efstathios N. Stathopoulos; Nikolaos M. Siafakas

2009-01-01

266

[Therapy of Hodgkin's lymphomas. Results of the German Hodgkin's Disease Study Group].  

PubMed

Between July 1983 and May 1987 143 untreated patients with Hodgkin's lymphoma in stages I-IIIA with risk factors qualified for the HD1 protocol, and 230 patients in stages IIIB/IV qualified for HD3. Patients in HD1 received a combined chemo-radiotherapy (2 x COPP + ABVD + 20 Gy EF vs. 40 Gy EF). Patients in HD3 received induction chemotherapy (3 x COPP + ABVD) and were randomized into consolidation by radiotherapy (20 Gy IF) vs. chemotherapy (1 x COPP + ABVD). In HD1, 73 of 89 evaluable patients (82%) achieved a complete remission. The survival of patients in stages I-IIIA with risk factors treated according to HD1 is as good as the survival of patients in stages I and II without risk factors. In HD3, 86 of 137 patients (63%) achieved complete remission after induction chemotherapy with 3 x COPP + ABVD. This is significantly better than the 31% complete remission rate observed in a pilot study with COPP alone (p less than 0.01). Including salvage therapy (radiotherapy in case of persisting nodal disease; chemotherapy with 4 x CEVD in case of persisting disseminated disease), a total of 76% complete remissions in stages IIIB/IVAB were achieved. An ESR greater than 80 mm/h was the most significant single risk factor in stages IIIB/IV for induction of CR and freedom from progression. PMID:2452393

Pfreundschuh, M; Löffler, M; Rühl, U; Hiller, E; Gerhartz, H; Wilmanns, W; Kirchner, H; Schoppe, W; Petsch, S; Bartels, H

1988-02-01

267

Ixazomib Citrate in Treating Patients With Untreated B-cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

B-Cell Non-Hodgkin Lymphoma; Chronic Lymphocytic Leukemia; Follicular Lymphoma; Lymphoplasmacytic Lymphoma; Mantle Cell Lymphoma; Marginal Zone Lymphoma; Small Lymphocytic Lymphoma; Waldenstrom Macroglobulinemia

2015-03-16

268

Unusual thoracic radiographic findings in children treated for Hodgkin's disease  

SciTech Connect

Mantle irradiation is often part of the treatment for Hodgkin's disease. Localized pneumonitis and fibrosis are well-known sequelae of this treatment. We report nine patients with unusual thoracic radiographic findings following treatment for Hodgkin's disease. All nine had mediastinal widening. Seven of these patients received combined modality therapy in which prednisone was given with their MOPP. In these seven patients, an increase in mediastinal width developed at the same time as the radiographic changes of radiation pneumonitis. Two patients developed bilateral infiltrates extending beyond the field of radiation to the lung periphery. In one of these patients, a spontaneous pneumomediastinum developed. One patient underwent mediastinal biopsy that revealed inflammatory changes similar to those seen in radiation pneumonitis. All patients either responded to steroids or had spontaneous regression of radiographic abnormalities supporting the presumed diagnosis of treatment related changes. Recognition of these unusual sequelae of mantle irradiation will aid in differentiating them from infection or tumor and lead to prompt, appropriate treatment.

Jochelson, M.S.; Tarbell, N.J.; Weinstein, H.J.

1986-06-01

269

Development of Graves' disease following radiation therapy in Hodgkin's disease  

SciTech Connect

Radiation-related thyroid dysfunction is a common occurrence in patients with Hodgkin's disease treated with mantle field radiation. Although chemical and clinical hypothyroidism are most commonly seen, Graves' disease has also been described. We have examined the records of 437 surgically staged patients who received mantle field irradiation between April 1969 and December 1980 to ascertain the frequency of manifestations of Graves' disease. Within this group, seven patients developed hyperthyroidism accompanied by ophthalmic findings typical of those seen in Graves' disease. The actuarial risk of developing Graves' disease at 10 years following mantle irradiation for Hodgkin's disease was 3.3% in female patients and 1% in male patients in this study. The observed/expected ratios were 5.9 and 5.1 for female and male patients, respectively. This observed risk significantly exceeded that seen in the general population.

Loeffler, J.S.; Tarbell, N.J.; Garber, J.R.; Mauch, P.

1988-01-01

270

Graves disease with ophthalmopathy following radiotherapy for Hodgkin's disease  

SciTech Connect

The number of patients achieving long-term survival following neck irradiation for Hodgkin's disease and other malignancies is increasing. Paralleling this increase in survivors is the development of late complications of the therapy itself. Eleven patients have previously been reported who developed Graves ophthalmopathy 18 months to seven years after receiving neck radiotherapy for nonthyroidal malignancies. The seven patients who had HLA typing were all HLA-B8 negative, despite the reported association of the HLA-B8 antigen with Graves disease. A patient who is HLA-B8 positive who developed Graves ophthalmopathy and hyperthyroidism nine years after receiving mantle radiotherapy for Hodgkin's disease is reported. It is recommended that Graves disease be included among the thyroid diseases that receive consideration during follow-up of patients who have received mantle radiotherapy.

Jacobson, D.R.; Fleming, B.J.

1984-12-01

271

Hypereosinophilic syndrome with Hodgkin's-like lymphoma in a ferret.  

PubMed

Hodgkin's-like lymphoma involving the lung, mediastinum, liver, kidneys and mesenteric lymph nodes was diagnosed in a ferret. The diagnosis was based on the presence of an admixture of CD3+ small lymphocytes with smaller numbers of macrophages, eosinophils, and large, pleomorphic, frequently multinucleated, Reed-Sternberg-like cells which were immunoreactive to BLA.36 monoclonal antibody. In addition, the liver, pancreas, small intestine and lungs were infiltrated with moderate to large numbers of eosinophils, forming eosinophilic granulomas with occasional deposition of Splendore-Hoeppli material, supporting a diagnosis of hypereosinophilic syndrome. The concurrent diagnosis of hypereosinophilic syndrome and Hodgkin's-like lymphoma in this ferret provides further support to the concept that, in animals, multisystemic eosinophilic infiltrates may be caused by the abnormal proliferation of T lymphocytes, as has been demonstrated in man. PMID:10087494

Blomme, E A; Foy, S H; Chappell, K H; La Perle, K M

1999-02-01

272

Thyroid neoplasia following radiation therapy for Hodgkin's lymphoma  

SciTech Connect

The question of thyroid neoplasia following high-dose radiation treatment to the neck and mediastinum for malignant neoplasms such as Hodgkin's lymphoma in children and young adults has been raised recently. Five patients, 19 to 39 years old, were operated on for thyroid neoplasms that developed following cervical and mediastinal radiation therapy for Hodgkin's lymphoma. Three patients had papillary carcinomas and two had follicular adenomas. The latency period between radiation exposure and the diagnosis of thyroid neoplasm ranged from eight to 16 years. This limited series provided strong support for the recommendation that children and young adults who are to receive high-dose radiation therapy to the head, neck, and mediastinum should receive suppressive doses of thyroxine prior to radiation therapy in order to suppress thyrotropin (thyroid-stimulating hormone) and then be maintained on a regimen of suppression permanently.

McHenry, C.; Jarosz, H.; Calandra, D.; McCall, A.; Lawrence, A.M.; Paloyan, E.

1987-06-01

273

Spleen in Hodgkin disease: diagnostic value of CT  

SciTech Connect

Findings of CT of the spleen were compared with those of histologic examination in 35 patients who had Hodgkin disease. CT provides a simple way to calculate splenic size. This index is also of value in the assessment of the histologic state of the spleen. An accuracy rate of 91%, specificity of 94%, and a sensitivity of 89% in diagnosing splenic localization of lymphoma was found in this study.

Strijk, S.P.; Wagener, D.J.T.; Bogman, M.J.J.T.; de Pauw, B.E.; Wobbes, T.

1985-03-01

274

Non-Hodgkin's lymphomas, version 1.2013.  

PubMed

These NCCN Guidelines Insights summarize several key updates to the NCCN Guidelines for Non-Hodgkin's Lymphomas (NHL) and provide a discussion of the clinical evidence that support the updates. The updates discussed in this article feature recommendations for additional treatment options in patients with chronic lymphocytic leukemia and guidance surrounding the management of hepatitis virus reactivation/infections in high-risk patients with NHL undergoing antitumor therapy. PMID:23486452

Zelenetz, Andrew D; Wierda, William G; Abramson, Jeremy S; Advani, Ranjana H; Andreadis, C Babis; Bartlett, Nancy; Bellam, Naresh; Byrd, John C; Czuczman, Myron S; Fayad, Luis E; Glenn, Martha J; Gockerman, Jon P; Gordon, Leo I; Harris, Nancy Lee; Hoppe, Richard T; Horwitz, Steven M; Kelsey, Christopher R; Kim, Youn H; Krivacic, Susan; LaCasce, Ann S; Nademanee, Auayporn; Porcu, Pierluigi; Press, Oliver; Pro, Barbara; Reddy, Nishitha; Sokol, Lubomir; Swinnen, Lode; Tsien, Christina; Vose, Julie M; Yahalom, Joachim; Zafar, Nadeem; Dwyer, Mary A; Naganuma, Maoko

2013-03-01

275

Failure to preserve fertility in patients with Hodgkin's disease  

Microsoft Academic Search

The hypothesis that the “down-regulated” gonad is less vulnerable to the effects of cytotoxic chemotherapy for advanced Hodgkin's disease has been investigated. Thirty men and eighteen women were randomly allocated to receive an agonist analogue of gonadotrophin-releasing hormone prior to, and for the duration of, cytotoxic chemotherapy. Buserelin (d-Ser-[TBU]6 LHRH ethylamide) was prescribed in two different dosage schedules to twenty

J. H. Waxman; R. Ahmed; D. Smith; P. F. M. Wrigley; W. Gregory; S. Shalet; D. Crowther; L. H. Rees; G. M. Besser; J. S. Malpas; T. A. Lister

1987-01-01

276

Chinese Tea Tea, a drink pioneered by the Chinese,  

E-print Network

and the least caffeine content of all Chinese tea classes. Aroma is medium to high, flavor is light to medium amount of caffeine in Chinese tea classes. PU'ER White Tea is sometimes considered a subclass of Green. It has very low caffeine content. Longevity Eyebrow KING Chinese Oolong Tea Oolong Tea is half way

277

Factors affecting physician visits in Chinese and Chinese immigrant samples  

Microsoft Academic Search

This study examines predictors of Western physician utilization using the Andersen's Behavioral Model of Health Services Use for Chinese elders who reside in Shanghai and immigrant Chinese elders who reside in the US Chinese elders are under-studied relative to their population size and in the US are known to underutilize the healthcare system. Underutilization is highly correlated with poor health

Helen B. Miltiades; Bei Wu

2008-01-01

278

KIR genotype distribution among Lebanese patients with Hodgkin's lymphoma  

PubMed Central

Introduction In addition to their important role in fighting infection, natural killer cells are cytotoxic to cancer cells. Studies demonstrated that some KIR genes were responsible for the reduction of the risk of Hodgkin's lymphoma (HL) while others were associated with an increased risk of HL. Aim The aim of this study is to assess KIR genotypic distribution in Lebanese patients with Hodgkin's lymphoma. Methods KIR genotype was analyzed in 41 HL patients and 120 healthy Lebanese individuals using the KIR Genotyping SSP kit. Results No significant association between HL and any KIR gene was found. Among HL patients, the AA, AB, and BB genotype frequencies were, respectively, 41.46%, 43.9% and 14.63% with an A:B ratio of 1.73:1. As for the controls, the AA, AB, and BB genotype frequencies were, respectively, 39.17%, 50%, and 10.83% with an A:B ratio of 1.79:1. Conclusion In this first study from the Mediterranean region, KIR genotype does not seem to be associated with Hodgkin's lymphoma. Further clinical and translational research is needed to rule out the protective or predisposing role of KIR genes in this important clinical entity.

Hoteit, Rouba; Abboud, Miguel; Bazarbachi, Ali; Salem, Ziad; Shammaa, Dina; Zaatari, Ghazi; Mahfouz, Rami

2015-01-01

279

Role of the gallium scan in Hodgkin's disease  

SciTech Connect

The reports of 240 gallium scans on 165 patients with Hodgkin's disease were reviewed to compare results with higher doses with those in earlier studies that employed lower doses. Tracer concentrations in specific sites were correlated with radiologic and pathologic reports and with the clinical courses of the patients studied. There were no significant differences in overall results between newer and older gallium scanning techniques. For untreated patients, the overall sensitivity was only 64%, but the overall specificity was 98%. For untreated patients and for patients with relapsing disease, the presence of gallium concentration in a specific site was highly predictive of active Hodgkin's disease at that site. However, for routine follow-up of treated patients, 95% of unsuspected relapses were missed by the scan, indicating the limited usefulness of negative scan results in this setting. For patients with residual abnormalities after therapy, demonstrated by other radiographic means, increased uptake of gallium in abdominal or peripheral lymph nodes also indicated active disease, although lack of uptake was reliable only in the mediastinum. Based on these results, it appears that the higher doses used in this study have not substantially improved the role of gallium scanning in this disease. Although it is potentially useful in providing confirmatory data at diagnosis or in patients with new or residual objective abnormalities after treatment, routine use of gallium scanning in Hodgkin's disease is not recommended.

Hagemeister, F.B.; Fesus, S.M.; Lamki, L.M.; Haynie, T.P. (Univ. of Texas, M.D. Anderson Cancer Center, Houston (USA))

1990-03-01

280

Functional hyposplenia after splenic irradiation for Hodgkin's disease  

SciTech Connect

We previously reported a patients who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n . 19) or non-Hodgkin's lymphoma (n . 6). Mean maximum splenic diameter as measured on a 99mTc-sulfur colloid liver-spleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p less than 0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p less than 0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

Coleman, C.N.; McDougall, I.R.; Dailey, M.O.; Ager, P.; Bush, S.; Kaplan, H.S.

1982-01-01

281

Functional hyposplenia after splenic irradiation for Hodgkins's disease  

SciTech Connect

We previously reported a patient who developed fulminant pneumococcal sepsis 12 years after successful treatment for Hodgkin's disease, which included splenic irradiation. We have since evaluated splenic size and function in 25 patients who had received splenic irradiation 5 to 16 years previously either for Hodgkin's disease (n = 19) or non-Hodgkin's lymphoma (n = 6). Mean maximum splenic diameter as measured on a /sup 99//sup m/Tc-sulfur colloid liver-spleen scan was 6.2 cm in the irradiated group and 9.7 cm in a control group (p < 0.001). The mean percentage of erythrocytes containing pits when observed with interference phase microscopy was 13.0% in the irradiated group, which was significantly different (p < 0.001) from the levels found in each of the control groups: normal subjects, 0.9%; unstaged and untreated lymphoma patients, 0.6%; and patients after splenectomy, 33.7%. Patients who have had splenic irradiation should be considered at risk of developing overwhelming pneumococcal sepsis.

Coleman, C.N.; McDougall, I.R.; Dailey, M.O.; Ager, P.; Bush, S.; Kaplan, H.S.

1982-01-01

282

Primary non-Hodgkin's lymphoma of the mediastinum  

SciTech Connect

Non-Hodgkin's lymphoma localized to the mediastinum and adjacent structures occurred in 12 of 215 (6%) non-Hodgkin's lymphoma patients seen at the Massachusetts General Hospital between 1975 and 1979. Lymphangiography, radionuclide scanning and whole body computerized tomography were used to exclude patients with extrathoracic disease at presentation. Eleven of the 12 patients presented with extensive contiguous extranodal disease (Stage II/sub E/) with involvement of either the pericardium, sternum, chest wall, pulmonary parenchyma or, in four cases, with superior venacaval obstruction. Diffuse large cell lymphoma (eight cases) and diffuse poorly differentiated lymphocytic lymphoma (four cases) were the prevalent histologic subtypes; no instances of lymphoblastic lymphoma without extra-thoracic spread were encountered. None of four lymphomas studied could be characterized as either B- or T-cell tumors utilizing conventional surface marker techniques. Ten of the 12 patients achieved complete remissions, either after treatment with combination chemotherapy alone (three patients) or after both chemotherapy and mediastinal irradiation (seven patients). Two of these ten have subsequently relapsed, but median survival has not been reached after a mean period of observation of 28 months. Primary nonlymphoblastic non-Hodgkin's lymphoma of the mediastinum is more common than previously realized, displays aggressive contiguous spread within the chest and responds well to combination chemotherapy with or without adjuvant mediastinal irradiation.

Levitt, L.J.; Aisenberg, A.C.; Harris, N.L.; Linggood, R.M.; Poppema, S.

1982-12-01

283

Traditional Chinese Medicine: An Introduction  

MedlinePLUS

... C, eds. A Comprehensive Guide to Chinese Medicine . River Edge, NJ: World Scientific Publishing Co.; 2003. Manheimer ... YC, eds. A Comprehensive Guide to Chinese Medicine . River Edge, NJ: World Scientific Publishing Co.; 2003. Vickers ...

284

The Early Chinese Canadians  

NSDL National Science Digital Library

This bilingual website offered by the Library and Archives of Canada (LAC) explores Canada's early Chinese immigrants, covering the period 1858 to 1947. To learn why the Chinese immigrated to Canada, visitors should click on "The History" on the far left side of the page. Once there, visitors can choose from several specific sections to read about, including "Working in B.C.: Gold, Railway, Mining and Salmon", "Racism and Law in Society", and "Communities for Canada and China". Additionally, each contains suggestions for further reading on the subject for both adults and children. Visitors who desire to browse photos and documents can click on "Historical Photographs and Documents" on the far left side of the page. There are three sections, "Research Guide", "Gallery of Documents", and "Gallery of Photographs". The Research Guide provides a thorough explanation on how to research the "photographs, artwork, published books, personal archives, and, in particular, government records" of Chinese Canadians, which are dispersed throughout the LAC collection. The documents and photographs galleries allow visitors to view, and even order, a print or digital copy of the historic materials. Finally, the "Head Tax Records" link located on the far left side of the page, allows visitors to search for Chinese immigrants to Canada that were recorded in the General Registers of Chinese Immigration. Visitors can search these registers online by the person's name, arrival year, or certificate number. [KMG

285

Ancient Chinese Astronomical Technologies  

NASA Astrophysics Data System (ADS)

I am interested in the astronomical advances of the Ancient Chinese in measuring the solar day. Their development of gnomon & ruler, sundial, and water clock apparatuses enabled Chinese astronomers to measure the annual solar orbit and solar day more precisely than their contemporaries. I have built one of each of these devices to use in collecting data from Olympia, Washington. I will measure the solar day in the Pacific Northwest following the methodology of the ancient Chinese. I will compare with my data, the available historical Chinese astronomical records and current records from the United States Naval Observatory Master Clock. I seek to understand how ancient Chinese investigations into solar patterns enabled them to make accurate predictions about the movement of the celestial sphere and planets, and to develop analytic tests of their theories. Mayall, R. Newton; Sundials: their construction and use. Dover Publications 2000 North, John; The Norton History of Astronomy and Cosmology W.W. Norton& Co. 1995 Zhentao Xu, David W. Pankenier, Yaotiao Jiang; East Asian archaeoastronomy : historical records of astronomical observations of China, Japan and Korea Published on behalf of the Earth Space Institute by Gordon and Breach Science Publishers, c2000

Walsh, Jennifer Robin

2004-05-01

286

A Century of Chinese Cinema  

E-print Network

A Century of Chinese Cinema This retrospective will begin with what is often regarded as one screenings focusing on new waves and new directions in Chinese cinema. Kindly supported by the Confucius Institute. On Monday 30 June (13.00 ­ 18.00), we will be running a one-day starter course on Chinese cinema

Guo, Zaoyang

287

Mapping Charisma in Chinese Religion  

E-print Network

3 Mapping Charisma in Chinese Religion Introduction and Glossary Vincent Goossaert and David Ownby T he study of Chinese religion has long been a divided field.1 Philologically grounded sinologists have) of contemporary Chinese religion. Recent events, however, have fundamentally changed the reality, the percep- tion

Paris-Sud XI, Université de

288

Voice dictation of Mandarin Chinese  

Microsoft Academic Search

The Chinese language is not alphabetic, and input of Chinese characters into computers remains a difficult problem even after decades of efforts made to overcome the problem. Voice dictation of Mandarin Chinese with a very large vocabulary is believed to be the perfect solution, but this is a highly challenging speech recognition problem with many technical issues yet unsolved. The

Lin-Shan Lee

1997-01-01

289

On Chinese Culture Curriculum Planning  

ERIC Educational Resources Information Center

The importance of cultural elements in foreign language teaching has been widely accepted in recent years. This applies particularly to the teaching of Chinese as a foreign language (TCFL) to non-native Chinese speakers at tertiary level in mainland China. However, there is no commonly accepted blueprint that defines the parts of Chinese culture…

Wang, Catherine

2006-01-01

290

Chinese American Experience: San Francisco.  

ERIC Educational Resources Information Center

This unit encourages students to explore the history and current situation of Chinese Americans. Organized around five lesson plans, the unit's first lesson begins with the students' own perceptions of Chinese Americans, followed by a quiz that provides relevant background information. The second lesson examines the general history of Chinese

Stanford Univ., CA. Stanford Program on International and Cross Cultural Education.

291

Supporting Chinese Speaking Skills Online  

ERIC Educational Resources Information Center

Chinese is considered a difficult language to learn by most Western learners, yet recently more and more people are learning Chinese, and increasingly teaching is delivered online. Due to the nature of Chinese and the complexity of online learning, research has not yet produced sufficient information on students' and teachers' interaction during…

Stickler, Ursula; Shi, Lijing

2013-01-01

292

Concepts of Chinese Folk Happiness  

ERIC Educational Resources Information Center

Discourses on Chinese folk happiness are often based on anecdotal narratives or qualitative analysis. Two traditional concepts of happiness popular in Chinese culture are introduced. The paper constructs a concept of Chinese folk happiness on basis of the findings of a scientific survey on the Taiwanese people regarding their concepts of…

Ip, Po Keung

2011-01-01

293

The Internet Classics Archive  

NSDL National Science Digital Library

The Internet Classics Archive has recently been extensively updated and more than doubled in size. This premier classical literature resource now offers 375 works by 30 classical authors, in English translation. The complete body of work is attractively and logically formatted for easy and swift browsing. It is supported by a newly improved search engine. The Tech Classics Archive is a non-commercial, student-created World-Wide Web site that will be one year old in October.

294

Effects of radiation therapy for Hodgkin's disease in a child with ataxia telangiectasia: a clinical, biological and pathologic study  

SciTech Connect

Stage I lymphocyte-predominant Hodgkin's disease was diagnosed in a 44-month-old girl. Although immune deficiency was suspected and IgA deficiency demonstrated, the diagnosis of an ataxia-telangiectasia (AT)-like syndrome was not confirmed until eight weeks later when results of studies on the radiosensitivity of cultured skin fibroblasts were available. The child had none of the usual physical stigmata of AT. Severe acute radiation damage followed the treatment of this child with standard doses of radiation therapy. Clinical, pathologic, and radiobiologic correlations are drawn. The diagnosis of a malignant lymphoma disorder in children under the age of five should alert clinicians to the possibility of immune deficiency and, even in the absence of classical physical signs, to AT in particular. Suggestions for the management of future similar cases are put forward.

Pritchard, J.; Sandland, M.R.; Breatnach, F.B.; Pincott, J.R.; Cox, R.; Husband, P.

1982-09-01

295

Hodgkin Disease: Hodgkin and Reed-Sternberg Cells Picked from Histological Sections Show Clonal Immunoglobulin Gene Rearrangements and Appear to be Derived from B Cells at Various Stages of Development  

Microsoft Academic Search

Hodgkin disease (HD) is characterized by a small number of putative malignant cells [Hodgkin and Reed-Sternberg (HRS) cells] among a background of lymphocytes and histiocytes. The lineage of HRS cells is still elusive and a clonal origin of these rare cells has not formally been demonstrated. We isolated HRS cells by micromanipulation from histological sections of three cases of Hodgkin

Ralf Kuppers; Klaus Rajewsky; Min Zhao; Gunther Simons; Ralf Laumann; Robert Fischer; Martin-Leo Hansmann

1994-01-01

296

[Recurrence of Hodgkin's disease after advanced primary stages. German Hodgkin's Study Group].  

PubMed

In a multicentre study on the treatment of Hodgkin's disease, 88 out of 297 patients with primary advanced stages IIIB/IV failed to respond to alternating COPP/ABVD chemotherapy +/- radiotherapy. They may be broken down as follows: tumour progression under current therapy (PD) 23/28, partial remission at the end of treatment (PR) 28/88, early nodal recurrence 13/88, late nodal recurrence 15/88, extranodal recurrence 7/88, unclear localisation 1/88. Thirty-six months after noting failure of treatment, 45% of all patients were still alive. The prognosis was poorest in the case of primary PD. Only 1/23 of these patients experience lasting complete remission thanks to salvage treatment (cCR). Eleven patients with an exclusively nodal recurrence experienced a cCR on treatment with radiation alone, and may be considered a low-risk recurrence group. For a high-risk recurrence group (n = 57), indication for high-dose chemotherapy with subsequent autologous bone marrow transplantation (HDC/ABMT) should have been recognized on the basis of the present definition. The survival probability of these patients, who only received conventional salvage treatment, was 38% after 30 months (95% confidence limit, 22 to 54%). These data would not appear to be appreciably poorer than those reported in the literature for comparable patients receiving HDC/ABMT. Only a randomized comparison would be capable of showing whether HDC/ABMT is superior to high-dose conventional chemotherapy with haematopoietic growth factors. It is proposed that such a therapeutic trial should be initiated as soon as possible. PMID:1281905

Fuchs, R; Löffler, M; Pfreundschuh, M; Dölken, G; Gerhartz, H; Hagen-Aukamp, U; Hiller, E; Petsch, S; Pflüger, K H; Rühl, U

1992-11-15

297

Hodgkin transformation of chronic lymphocytic leukemia: Incidence, outcomes, and comparison to de novo Hodgkin lymphoma.  

PubMed

Although transformation to Hodgkin lymphoma (HL) is a recognized complication in patients with chronic lymphocytic leukemia (CLL), its incidence, clinical characteristics and outcomes are not well defined. We used the Mayo Clinic CLL and Lymphoma Databases to identify CLL patients who developed biopsy-proven HL (CLL/HL) on follow-up, as well as cases of de novo HL (i.e., without prior CLL). Among 3887 CLL patients seen at Mayo Clinic from January 1995 through August 2011, 26 (0.7%) developed HL. In a nested cohort of 2,465 newly diagnosed CLL patients followed prospectively, the incidence of HL was 0.05%/year (10 year risk?=?0.5%). The median overall survival (OS) from date of HL diagnosis in patients with CLL/HL was 3.9 years compared to not reached for de novo HL patients (n?=?709) seen during the same time interval (P?

Parikh, Sameer A; Habermann, Thomas M; Chaffee, Kari G; Call, Timothy G; Ding, Wei; Leis, Jose F; Macon, William R; Schwager, Susan M; Ristow, Kay M; Porrata, Luis F; Kay, Neil E; Slager, Susan L; Shanafelt, Tait D

2015-04-01

298

Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma or Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-cell Lymphoma; Cutaneous B-cell Non-Hodgkin Lymphoma; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Hepatosplenic T-cell Lymphoma; Intraocular Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Peripheral T-Cell Lymphoma; Post-transplant Lymphoproliferative Disorder; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Adult T-cell Leukemia/Lymphoma; Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Recurrent Small Lymphocytic Lymphoma; Small Intestine Lymphoma; Splenic Marginal Zone Lymphoma; Testicular Lymphoma; Waldenstrom Macroglobulinemia

2010-12-08

299

The Classics Revivified.  

ERIC Educational Resources Information Center

The eight articles in this bulletin suggest methods of introducing classical literature into the English curriculum. Article titles are: "Ideas for Teaching Classical Mythology"; "What Novels Should High School Students Read?"; "Enlivening the Classics for Live Students"; "Poetry in Performance: The Value of Song and Oral Interpretation in…

Matthews, Dorothy, Ed.

1979-01-01

300

The Classical Vacuum.  

ERIC Educational Resources Information Center

The classical vacuum of physics is not empty, but contains a distinctive pattern of electromagnetic fields. Discovery of the vacuum, thermal spectrum, classical electron theory, zero-point spectrum, and effects of acceleration are discussed. Connection between thermal radiation and the classical vacuum reveals unexpected unity in the laws of…

Boyer, Timothy H.

1985-01-01

301

On Classical Teleportation and Classical Nonlocality  

Microsoft Academic Search

An interesting protocol for classical teleportation of an unknown classical\\u000astate was recently suggested by Cohen, and by Gour and Meyer. In that protocol,\\u000aBob can sample from a probability distribution P that is given to Alice, even\\u000aif Alice has absolutely no knowledge about P. Pursuing a similar line of\\u000athought, we suggest here a limited form of nonlocality

Tal Mor

2005-01-01

302

Bibliographies for Chinese Studies  

NSDL National Science Digital Library

Professor Dr. Barend ter Haar, an instructor in the social and economic history of China at the Sinologisches Seminar (Sinological Institute) at Heidelberg University, offers this collection of regularly updated (with one exception) bibliographies on various aspects of Chinese culture and history. Topics include violence in Chinese culture, literacy, writing and education, the study of Yao religion, Shamanism in China, and religious culture in China. Each bibliography varies in length, but most are prefaced by some helpful remarks on the field and/or the secondary literature. Suggestions are welcome.

303

Chinese Foreign Policy Net  

NSDL National Science Digital Library

Developed by M. Taylor Fravel of Stanford University, Chinese Foreign Policy Net is a compendium of online information resources related to the study of Chinese foreign relations. The site organizes resources into sections that cover major issues: Security, Trade, Human Rights, and Bilateral Relations. Information resources include news services, academic reports, think tank policy papers, government documents, scholarly journals, economic data sets, and much more. The site also links to numerous academic and military research centers monitoring the foreign policy of People's Republic of China.

304

Antivir Ther . Author manuscript Incidence and risk factors of HIV-related non-Hodgkins lymphoma in the'  

E-print Network

Antivir Ther . Author manuscript Page /1 11 Incidence and risk factors of HIV-related non-Hodgkins-associated non-Hodgkin lymphoma (NHL) are not well defined in the era of combination antiretroviral therapy (cART. Author Keywords non-Hodgkin lymphoma ; cohort studies ; antiretroviral therapy ; Kaposi sarcoma

Paris-Sud XI, Université de

305

Stability of synchronous oscillations in a system of Hodgkin-Huxley neurons with delayed diffusive and pulsed coupling  

E-print Network

Stability of synchronous oscillations in a system of Hodgkin-Huxley neurons with delayed diffusive dynamics for a system of two Hodgkin-Huxley HH neurons coupled diffu- sively or through pulselike, such as the Hodgkin- Huxley HH model. Indeed, numerical experiments reported by many authors show that when two

Feng, Jianfeng

306

Incidence and risk factors of HIV-related non-Hodgkin lymphoma in the era of combination antiretroviral therapy  

E-print Network

1 Incidence and risk factors of HIV-related non-Hodgkin lymphoma in the era of combination at the end of the article Running head: HIV-related non-Hodgkin lymphoma in the era of antiretroviral therapy2009 #12;2 Abstract Background: Incidence and risk factors of HIV-associated non-Hodgkin lymphoma (NHL

307

The Asymptotic Structure of the Hodgkin-Huxley Equations Rebecca Suckley 1 and Vadim N. Biktashev 1;2;  

E-print Network

The Asymptotic Structure of the Hodgkin-Huxley Equations Rebecca Suckley 1 and Vadim N. Biktashev 1 correspondence should be addressed. Abstract We analyse the asymptotic structure of the Hodgkin-Huxley system approaches. 1 Introduction Fifty years ago, Hodgkin & Huxley (1952) suggested a system of di#11;erential

Biktashev, Vadim N.

308

Silicon Phthalocyanine 4 and Photodynamic Therapy in Stage IA-IIA Cutaneous T-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Recurrent Cutaneous T-cell Non-Hodgkin Lymphoma; Recurrent Mycosis Fungoides/Sezary Syndrome; Stage I Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IA Mycosis Fungoides/Sezary Syndrome; Stage IB Mycosis Fungoides/Sezary Syndrome; Stage II Cutaneous T-cell Non-Hodgkin Lymphoma; Stage IIA Mycosis Fungoides/Sezary Syndrome

2014-09-16

309

Recent progress of traditional chinese medicine and herbal medicine for the treatment and prevention of cancer  

Microsoft Academic Search

Conclusion  TCM represents the enormous accumulation of daily experiences in medical practice by the Chinese people from ancient time.\\u000a The description of the therapeutic usage in classic books of Chinese materia medica are informative even today, for example,\\u000a Angelica sinensis ameliorates menstruation disorder and Artemisia annua is effective against malaria. All these therapeutic\\u000a effects have been confirmed by contemporary scientific research.

Rui Han

1995-01-01

310

Chinese traditional thought and practice: lessons for an ecological economics worldview  

Microsoft Academic Search

This paper argues the need for a moral dimension, lacking in the neo-classical paradigm, to humanity's relationship with the natural world. Against this background, it reviews Chinese philosophical\\/religious traditions of Confucianism, Taoism, Buddhism, neo-Confucianism, and popular religious practice. The Chinese worldview derived from these traditions is based on ideals of harmony, human perfectibility and systemic fit within natural systems and

T. N. Jenkins

2002-01-01

311

Alisertib in Treating Patients With Relapsed or Refractory Peripheral T-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nasal Type Extranodal NK/T-Cell Lymphoma; Anaplastic Large Cell Lymphoma; Angioimmunoblastic T-Cell Lymphoma; Hepatosplenic T-Cell Lymphoma; Mature T-Cell and NK-Cell Non-Hodgkin Lymphoma; Recurrent Adult Non-Hodgkin Lymphoma; Recurrent Adult T-Cell Leukemia/Lymphoma

2015-03-26

312

SURVIVAL AFTER CHILDHOOD ACUTE LEUKEMIA AND NON-HODGKIN'S LYMPHOMA IN FRANCE, 1990-2000.  

E-print Network

1/19 SURVIVAL AFTER CHILDHOOD ACUTE LEUKEMIA AND NON-HODGKIN'S LYMPHOMA IN FRANCE, 1990 describes the survival after childhood acute leukemia (AL) and non- Hodgkin's lymphoma (NHL) of the French population aged less than 15 years. The French National Registry of Childhood Leukemia and Lymphoma recorded

Paris-Sud XI, Université de

313

RESEARCH Open Access Age-period-cohort modelling of non-Hodgkin's  

E-print Network

RESEARCH Open Access Age-period-cohort modelling of non-Hodgkin's lymphoma incidence in a French2 , Arlette Danzon2 Abstract Background: The incidence of non-Hodgkin's lymphoma (NHL) has risen. Background The aetiology of the most common forms of non-Hodg- kin's lymphoma (NHL) remains elusive [1

Paris-Sud XI, Université de

314

Environmental and Behavioral Factors and the Risk of Non-Hodgkin Lymphoma  

E-print Network

Environmental and Behavioral Factors and the Risk of Non-Hodgkin Lymphoma Patricia Hartge1 for non-Hodgkin lymphoma (NHL) increased steadily and substantially over the last five decades of the 20th the risk of developing lymphoma and may have contributed to the long-term increase in rates. Our current

California at Berkeley, University of

315

Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma  

E-print Network

-control study of non- Hodgkin lymphoma (NHL) conducted in the San Francisco Bay Area between 1988 and 1995NEOPLASIA Polymorphisms and haplotypes in folate-metabolizing genes and risk of non-Hodgkin lymphoma Christine F. Skibola, Matthew S. Forrest, Fabio Coppede´, Luz Agana, Alan Hubbard, Martyn T. Smith

California at Berkeley, University of

316

Primary multifocal osseous Hodgkin disease: a case report and review of the literature  

Microsoft Academic Search

Purpose Hodgkin disease (HD) typically involves the lymphatic system at one or more sites. Rarely, Hodgkin disease presents as an osseous lesion without involvement of lymph nodes. Therefore, the histologic diagnosis of osseous HD can be problematic. We present a rare case of multifocal osseous HD and a review the literature with special emphasis on treatment and prognosis.Methods Osteomyelitis and

C. Gebert; J. Hardes; H. Ahrens; H. Buerger; W. Winkelmann; G. Gosheger

2005-01-01

317

Channel-noise-induced critical slowing in the subthreshold Hodgkin-Huxley neuron  

NASA Astrophysics Data System (ADS)

The dynamics of a spiking neuron approaching threshold is investigated in the framework of Markov-chain models describing the random state-transitions of the underlying ion-channel proteins. We characterize subthreshold channel-noise-induced transmembrane potential fluctuations in both type-I (integrator) and type-II (resonator) parametrizations of the classic conductance-based Hodgkin-Huxley equations. As each neuron approaches spiking threshold from below, numerical simulations of stochastic trajectories demonstrate pronounced growth in amplitude simultaneous with decay in frequency of membrane voltage fluctuations induced by ion-channel state transitions. To explore this progression of fluctuation statistics, we approximate the exact Markov treatment with a 12-variable channel-based stochastic differential equation (SDE) and its Ornstein-Uhlenbeck (OU) linearization and show excellent agreement between Markov and SDE numerical simulations. Predictions of the OU theory with respect to membrane potential fluctuation variance, autocorrelation, correlation time, and spectral density are also in agreement and illustrate the close connection between the eigenvalue structure of the associated deterministic bifurcations and the observed behavior of the noisy Markov traces on close approach to threshold for both integrator and resonator point-neuron varieties.

Bukoski, Alex; Steyn-Ross, D. A.; Steyn-Ross, Moira L.

2015-03-01

318

Giant squid-hidden canard: the 3D geometry of the Hodgkin-Huxley model.  

PubMed

This work is motivated by the observation of remarkably slow firing in the uncoupled Hodgkin-Huxley model, depending on parameters tau( h ), tau( n ) that scale the rates of change of the gating variables. After reducing the model to an appropriate nondimensionalized form featuring one fast and two slow variables, we use geometric singular perturbation theory to analyze the model's dynamics under systematic variation of the parameters tau( h ), tau( n ), and applied current I. As expected, we find that for fixed (tau( h ), tau( n )), the model undergoes a transition from excitable, with a stable resting equilibrium state, to oscillatory, featuring classical relaxation oscillations, as I increases. Interestingly, mixed-mode oscillations (MMO's), featuring slow action potential generation, arise for an intermediate range of I values, if tau( h ) or tau( n ) is sufficiently large. Our analysis explains in detail the geometric mechanisms underlying these results, which depend crucially on the presence of two slow variables, and allows for the quantitative estimation of transitional parameter values, in the singular limit. In particular, we show that the subthreshold oscillations in the observed MMO patterns arise through a generalized canard phenomenon. Finally, we discuss the relation of results obtained in the singular limit to the behavior observed away from, but near, this limit. PMID:17458557

Rubin, Jonathan; Wechselberger, Martin

2007-07-01

319

Pyrogen Release in Vitro by Lymphoid Tissues from Patients with Hodgkin's Disease , 12  

PubMed Central

The mechanism of fever in patients with Hodgkin's disease was investigated by examining endogenous pyrogen production by blood, spleen, and lymph node cells incubated in vitro. Blood leucocytes from febrile or afebrile patients with Hodgkin's disease did not produce pyrogen spontaneously. Spleen cells, however, frequently released pyrogen during initial incubations, unlike spleen cells from patients with non-malignant diseases. Pyrogen production occurred from spleens without observed pathologic infiltrates of Hodgkin's disease. Lymph nodes involved with Hodgkin's disease produced pyrogen more frequently than did nodes involved with other diseases. Pyrogen production by tissue cells was prolonged, required protein synthesis, and in some cases was due to mononuclear cells; it did not correlate with fever in the patient. These studies demonstrate spontaneous production of endogenous pyrogen in vitro by lymphoid tissue cells from patients with Hodgkin's disease. PMID:4611062

Bodel, Phyllis

1974-01-01

320

The Chinese House Game.  

ERIC Educational Resources Information Center

Discussion of the use of simulations to teach international relations (IR) highlights the Chinese House Game, a computer-based decision-making game based on Inter Nation Simulation (INS). Topics discussed include the increasing role of artificial intelligence in IR simulations, multi-disciplinary approaches, and the direction of IR as a…

Lee, James R.

1989-01-01

321

Chinese Festivals and Customs.  

ERIC Educational Resources Information Center

Traditional festivals and customs of the Chinese people are described in this publication which can be used with secondary level students. In the margins of the text are numbers which indicate slides and cultural objects that relate to the text. The text, however, can be used without the slides and objects. The following festivals are described:…

Green, Sandra Aili

322

Chinese Education in Diplomacy  

Microsoft Academic Search

This article reflects upon contemporary education in Chinese diplomacy covering three aspects: curriculum contents, teaching methods and teaching goals. It argues that the curriculum contents have the following shortcomings: poor awareness of the real problems in China's diplomatic practices, lack of global awareness that is consistent with China's image as a great country, blurring of the boundaries between academic and

Xi Xiao

2012-01-01

323

Chinese "Magic" Mirrors.  

ERIC Educational Resources Information Center

Chinese "magic" mirrors are made from bronze with the front side a mirror and the reverse side a molded image. When light is reflected from the mirror,the image on the reverse side appears. Discusses reflections of conventional mirrors, possible explanations for the magic mirror phenomenon, and applications of the phenomenon to semiconductor…

Swinson, Derek B.

1992-01-01

324

Chinese New Year Dragons.  

ERIC Educational Resources Information Center

Presents an art project, used in a culturally diverse curriculum, in which second grade students create Chinese New Year dragons. Describes the process of creating the dragons, from the two-week construction of the head to the accordion-folded bodies. (CMK)

Balgemann, Linda

2000-01-01

325

Constitutively overexpressed 21 kDa protein in Hodgkin lymphoma and aggressive non-Hodgkin lymphomas identified as cytochrome B5b (CYB5B)  

Microsoft Academic Search

BACKGROUND: We have previously reported a novel constitutively overexpressed 21 kDa protein in Hodgkin Lymphoma (HL) and aggressive Non-Hodgkin Lymphomas (NHL). The objective of the current study was to 1) identify this protein using two independent methods, 2) study the expression of the protein and its encoding mRNA in reactive lymph nodes, normal lymphocytes and CD34+ bone marrow precursor cells,

Derek Murphy; Jeremy Parker; Minglong Zhou; Faisal M Fadlelmola; Christian Steidl; Aly Karsan; Randy D Gascoyne; Hong Chen; Diponkar Banerjee

2010-01-01

326

Epigenetic regulation of CD44 in Hodgkin and non-Hodgkin lymphoma  

PubMed Central

Background Epigenetic inactivation of tumor suppressor genes (TSG) by promoter CpG island hypermethylation is a hallmark of cancer. To assay its extent in human lymphoma, methylation of 24 TSG was analyzed in lymphoma-derived cell lines as well as in patient samples. Methods We screened for TSG methylation using methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) in 40 lymphoma-derived cell lines representing anaplastic large cell lymphoma, Burkitt lymphoma (BL), diffuse large B-cell lymphoma (DLBCL), follicular lymphoma (FL), Hodgkin lymphoma and mantle cell lymphoma (MCL) as well as in 50 primary lymphoma samples. The methylation status of differentially methylated CD44 was verified by methylation-specific PCR and bisulfite sequencing. Gene expression of CD44 and its reactivation by DNA demethylation was determined by quantitative real-time PCR and on the protein level by flow cytometry. Induction of apoptosis by anti-CD44 antibody was analyzed by annexin-V/PI staining and flow cytometry. Results On average 8 ± 2.8 of 24 TSG were methylated per lymphoma cell line and 2.4 ± 2 of 24 TSG in primary lymphomas, whereas 0/24 TSG were methylated in tonsils and blood mononuclear cells from healthy donors. Notably, we identified that CD44 was hypermethylated and transcriptionally silenced in all BL and most FL and DLBCL cell lines, but was usually unmethylated and expressed in MCL cell lines. Concordant results were obtained from primary lymphoma material: CD44 was not methylated in MCL patients (0/11) whereas CD44 was frequently hypermethylated in BL patients (18/29). In cell lines with CD44 hypermethylation, expression was re-inducible at mRNA and protein levels by treatment with the DNA demethylating agent 5-Aza-2'-deoxycytidine, confirming epigenetic regulation of CD44. CD44 ligation assays with a monoclonal anti-CD44 antibody showed that CD44 can mediate apoptosis in CD44+ lymphoma cells. CD44 hypermethylated, CD44- lymphoma cell lines were consistently resistant towards anti-CD44 induced apoptosis. Conclusion Our data show that CD44 is epigenetically regulated in lymphoma and undergoes de novo methylation in distinct lymphoma subtypes like BL. Thus CD44 may be a promising new epigenetic marker for diagnosis and a potential therapeutic target for the treatment of specific lymphoma subtypes. PMID:20920234

2010-01-01

327

Treatment of patients with minimal stage IIIA Hodgkin's disease  

SciTech Connect

Treatment recommendations for patients with upper abdominal Stage IIIA Hodgkin's (III1A) disease have varied widely. The current study reports on a combined institutional retrospective review of 85 patients with surgically staged III1A Hodgkin's disease. Twenty-two patients received combined modality therapy (CMT), 36 patients were treated initially with total nodal irradiation (TNI), and 27 with mantle and para-aortic radiotherapy (MPA). Patients treated with CMT had an actuarial 8-year freedom from relapse (FFR) of 96% as compared to a FFR of 51% in TNI treated patients (p = 0.002), and a FFR of 54% in MPA treated patients (p = 0.004). Of the 11 relapses in MPA treated patients, 7 had a component of their failure in the untreated pelvic or inguinal nodes. The patients treated with CMT had an 8-year actuarial survival of 100% as compared to 79% in TNI treated patients (p = 0.055) and 78% in patients treated with MPA (p = 0.025). Histology and the number of splenic nodules were the most important prognostic variables. Patients with MC/LD histology and greater than or equal to 5 splenic nodules have a high risk of relapse (10/13) when treated with radiation alone (TNI or MPA). We recommend CMT for this group of patients. Patients with NS/LP histology and 1-4 splenic nodules represent a favorable subset of Stage III1A patients. Only 4/21 patients have relapsed and all 21 patients are currently alive without disease regardless of treatment. We currently feel that patients with Stage III1A Hodgkin's disease with NS/LP histology and splenic disease limited to 1-4 nodules are good candidates for MPA as an alternative to TNI or CMT.

Powlis, W.D.; Mauch, P.; Goffman, T.; Goodman, R.L.

1987-10-01

328

The Chinese learner – a question of style  

Microsoft Academic Search

This paper challenges any misconceptions that Westerners may have about Chinese learning styles by highlighting how the Chinese mind operates and why certain styles of learning are preferred by Chinese students. The author discusses some of the reasons for the over-emphasis on education for the Chinese overseas, how cultural values and beliefs have helped to shape Chinese thinking and how

Sally Chan

1999-01-01

329

Chinese New Year Materials for Elementary Teachers.  

ERIC Educational Resources Information Center

This is a resource book designed to be used by teachers in Chinese bilingual bicultural programs. The materials in the book are based on Chinese New Year customs still observed in Chinese-American communities. The resource book contains five types of materials: (1) a general introduction to the Chinese New Year, including the Chinese Lunar Year…

Kwok, Irene

330

Esophageal obstruction 14 years after treatment for Hodgkin's disease  

SciTech Connect

The incidence of late radiation injury of the esophagus is not precisely determined but, overall, the occurrence of clinically apparent damage is infrequent. The authors report a complete esophageal obstruction in a 21-year-old man, 14 years after chemo-radiation therapy for Hodgkin's lymphoma. Although endoscopy failed to demonstrate a gross morphologic abnormality, an esophagogram detected abnormal peristalsis and stricture, and esophageal manometry coupled with dynamic isotopic study clearly demonstrated a multilevel secondary neuronal damage. Data in the literature suggest that alteration in motility is by far the most frequent radiologic manifestation. Further prospective studies will probably clarify the actual incidence of late esophageal damage after chemo-radiation therapy.

Kaplinsky, C.; Kornreich, L.; Tiomny, E.; Cohen, I.J.; Loven, D.; Zaizov, R. (Beilinson Medical Center, Petah Tiqva (Israel))

1991-08-15

331

Sezary syndrome after successful treatment of Hodgkin's Disease  

SciTech Connect

A patient had a cutaneous T-cell lymphoma, appearing clinically as Sezary syndrome, that developed two years after successful treatment of Hodgkin's disease with combined radiotherapy and chemotherapy. Clinical, histologic, and electron microscopic observations were made during the course of the Sezary syndrome. The malignant cells in the cell infiltrates and in the peripheral blood were characterized as T cells. There is a possible relationship of the cutaneous T-cell lymphoma to impaired immune surveillance in this patient and to the potential carcinogenicity of combined radiotherapy and chemotherapy.

Buechner, S.A.

1981-01-01

332

Breast cancer after Hodgkin's disease in two sisters  

SciTech Connect

Two sisters had breast cancer at four years and 11 years after diagnosis of Hodgkin's disease. The affected breast tissues had received several hundred rads of scatter radiation during treatment of the lymphoma. Family history revealed breast cancer in a third sister and five other women in the paternal line. Cytogenetic and HLA studies showed no markers of susceptibility to neoplasia. Development of second primary neoplasms of the breast in the two sisters may have resulted from interactions between genetic factors and carcinogenic effects of radiation exposure.

Li, F.P.; Corkery, J.; Canellos, G.; Neitlich, H.W.

1981-01-01

333

Bordetella bronchiseptica infection in stage IV Hodgkin's disease  

PubMed Central

It is well known that patients with lymphoproliferative disorders have an altered immune status and are susceptible to opportunistic and non-opportunistic infections. The authors report the first case of a patient with advanced Hodgkin's disease who developed pneumonia caused by the animal pathogen Bordetella bronchiseptica. The most likely source of this organism was the patient's dog. While B. bronchiseptica is often responsible for outbreaks of pneumonia and septicaemia in wild and domestic animals, its role and incidence in human infections is not known. It is felt that patients with underlying lymphoproliferative diseases and pneumonia should be questioned about any contact with animals. PMID:7339608

Stoll, David B.; Murphey, Shelia A.; Ballas, Samir K.

1981-01-01

334

[Malignant pleural mesothelioma after radiation treatment for Hodgkin lymphoma].  

PubMed

Malignant mesothelioma is a relatively uncommon malignancy. Although the pathogenesis is primarily related to asbestos, the role of ionizing radiation is more controversial. We report the case of a 41-year-old male who developed pleural mesothelioma. He had both, a prior short asbestos exposure and a thoracic radiotherapy for Hodgkin's disease 26years before. The evidence for radiotherapy as cause for mesothelioma is expanding and the diagnosis of mesothelioma in patients who had previous irradiation should be kept in mind. PMID:23796498

Vandenbos, F; Figueredo, M; Dumon-Gubeno, M-C; Nicolle, I; Tarhini, A; Butori, C; Mouroux, J

2013-10-01

335

Compressive Optic Neuropathy Caused by Orbital Non-Hodgkin's Lymphoma  

PubMed Central

Purpose. To present a unique case of Non-Hodgkin's-Lymphoma- (NHL) associated compressive optic neuropathy. Method. An 89-year-old male presenting with acute unilateral visual loss and headache. Results. Patient was initially diagnosed with occult giant cell arteritis; however after visual acuity deteriorated despite normal inflammatory markers, an urgent MRI scan revealed an extensive paranasal sinus mass compressing the optic nerve. Conclusion. Paranasal sinus malignancies occasionally present to the ophthalmologist with signs of optic nerve compression and must be included in the differential diagnosis of acute visual loss. PMID:22606505

Ziaei, Mohammed M.; Ziaei, Hadi

2012-01-01

336

The Management of Elderly Patients with Hodgkin Lymphoma  

Microsoft Academic Search

\\u000a \\u000a The treatment of Hodgkin lymphoma (HL) has been substantially improved during the past decades. Using stage-adapted poly-chemotherapy\\u000a regimens and innovative radiation techniques, the 5-years progression-free survival (PFS) has reached almost 90% in young\\u000a patients (N Engl J Med 348:2386–95, 2003; J Clin Oncol 20:630–7, 2002; J Clin Oncol 20:2988–94, 2002). Since the median age\\u000a at first diagnosis is around 32

Peter Borchmann; Teresa Halbsguth; Stephen J. Proctor

337

From the Hodgkin-Huxley axon to the virtual heart  

PubMed Central

Experimentally based models of the heart have been developed since 1960, starting with the discovery and modelling of potassium channels. The early models were based on extensions of the Hodgkin–Huxley nerve impulse equations. The first models including calcium balance and signalling were made in the 1980s and have now reached a high degree of physiological detail. During the 1990s these cell models have been incorporated into anatomically detailed tissue and organ models to create the first virtual organ, the Virtual Heart. With over 40 years of interaction between simulation and experiment, the models are now sufficiently refined to begin to be of use in drug development. PMID:17023502

Noble, Denis

2007-01-01

338

Factors affecting physician visits in Chinese and Chinese immigrant samples.  

PubMed

This study examines predictors of Western physician utilization using the Andersen's Behavioral Model of Health Services Use for Chinese elders who reside in Shanghai and immigrant Chinese elders who reside in the US Chinese elders are under-studied relative to their population size and in the US are known to underutilize the healthcare system. Underutilization is highly correlated with poor health and well-being. A unique dataset allowed us to examine predictors of physician utilization for Chinese elders who resided in different countries, in an effort to determine how being an immigrant affects utilization. One hundred and seventy-seven Chinese elders in Boston and 420 Chinese elders in Shanghai participated in the survey. Multiple regression analyses were conducted separately for each sample. Predictors of physician visits for the Boston sample are insurance status, health, and social network, and for the Shanghai sample, use of Chinese medicine, health, and marital status predicted physician visits. We found that access to care variables significantly affects physician utilization for immigrant elders, and that Chinese elders in Shanghai utilize a bicultural system of care. The results indicate that in order to create effective healthcare practices for elder Chinese, alternative healthcare beliefs should be understood by Western physicians. PMID:17996348

Miltiades, Helen B; Wu, Bei

2008-02-01

339

Sperm quality before treatment in patients with early stage Hodgkin’s lymphoma enrolled in EORTC-GELA Lymphoma Group trials  

PubMed Central

Background Although widely recommended, cryopreservation of sperm is sometimes not performed for patients with Hodgkin’s lymphoma because of presumed poor sperm quality related to the disease. We investigated sperm quality and factors determining it in untreated patients with early stage Hodgkin’s lymphoma. Design and Methods Of 2362 males who participated in EORTC H6–H9 trials, 474 (20%) had data available. Sperm quality was defined according to World Health Organization guidelines. Determining factors were studied by logistic regression analysis. Results The median sperm concentration was 40×106/mL (range, 0–345×106/mL) and the median motility 50% (range, 0–90%). Sperm quality was good (concentration ?20×106/mL and motility ?50%), intermediate (concentration ?5×106/mL) and poor (concentration <5×106/mL but >0) in 41%, 49% and 7% of patients, respectively. Three percent of the patients were azoospermic. No relation was found between sperm quality and age or clinical stage of the Hodgkin’s lymphoma, but B-symptoms and elevated erythrocyte sedimentation rate predicted poor sperm quality. The odds ratios for the association of poor sperm quality with the variables examined were: presence of B-symptoms, 2.77 (95% CI, 1.50–5.12; p=0.001); erythrocyte sedimentation rate of 50 mm/h or greater, 2.35 (95% CI, 1.24–4.43; p=0.009); fever, 3.22 (95% CI, 1.41–7.33; p=0.005), and night sweats, 3.78 (95% CI, 1.97–7.26; p<0.001). There was no relation between sperm quality and pre-treatment follicle stimulating hormone level. Conclusions In this large study of males with Hodgkin’s lymphoma, 90% had good or intermediate sperm quality. Three percent were azoospermic. There was an association between sperm quality and the presence or absence of B-symptoms, in particular fever and night sweats. With modern fertilization techniques, in most patients with early-stage Hodgkin’s lymphoma sperm quality before treatment is good enough for future fatherhood. PMID:19850901

van der Kaaij, Marleen A.E.; Heutte, Natacha; van Echten-Arends, Jannie; Raemaekers, John M.M.; Carde, Patrice; Noordijk, Evert M.; Fermé, Christophe; Thomas, José; Eghbali, Houchingue; Brice, Pauline; Bonmati, Caroline; Henry-Amar, Michel; Kluin-Nelemans, Hanneke C.

2009-01-01

340

British Museum: Chinese Jade  

NSDL National Science Digital Library

The world of jade is utterly fascinating, and those captivated by this material will have a field day here. This online tour is part of the British Museum's commitment to broadening access to their vast array of items that might not normally be visible to the general public. Here, visitors can learn about the Chinese fascination with jade through 21 slides that profile unique and valuable items constructed of jade. The tour illustrates the development of Chinese jade from around 5000 BC to the modern period. The items here include lovely, long, and smooth Neolithic blades to later plaques, ornaments, dragons, animal and human sculptures. First-time visitors simply must start by looking at the magnificent coiled dragon that offers smooth contours and compelling details.

2003-01-01

341

Occupational exposure to pesticides and risk of non-Hodgkin's lymphoma.  

PubMed

Pesticide exposure may be a risk factor for non-Hodgkin's lymphoma, but it is not certain which types of pesticides are involved. A population-based case-control study was undertaken in 2000-2001 using detailed methods of assessing occupational pesticide exposure. Cases with incident non-Hodgkin's lymphoma in two Australian states (n = 694) and controls (n = 694) were chosen from Australian electoral rolls. Logistic regression was used to estimate the risks of non-Hodgkin's lymphoma associated with exposure to subgroups of pesticides after adjustment for age, sex, ethnic origin, and residence. Approximately 10% of cases and controls had incurred pesticide exposure. Substantial exposure to any pesticide was associated with a trebling of the risk of non-Hodgkin's lymphoma (odds ratio = 3.09, 95% confidence interval: 1.42, 6.70). Subjects with substantial exposure to organochlorines, organophosphates, and "other pesticides" (all other pesticides excluding herbicides) and herbicides other than phenoxy herbicides had similarly increased risks, although the increase was statistically significant only for "other pesticides." None of the exposure metrics (probability, level, frequency, duration, or years of exposure) were associated with non-Hodgkin's lymphoma. Analyses of the major World Health Organization subtypes of non-Hodgkin's lymphoma suggested a stronger effect for follicular lymphoma. These increases in risk of non-Hodgkin's lymphoma with substantial occupational pesticide exposure are consistent with previous work. PMID:16177143

Fritschi, L; Benke, G; Hughes, A M; Kricker, A; Turner, J; Vajdic, C M; Grulich, A; Milliken, S; Kaldor, J; Armstrong, B K

2005-11-01

342

Coming This Fall: Common Chinese Medicinal Plants  

E-print Network

Coming This Fall: Common Chinese Medicinal Plants Identification, Classification and Application used Chinese medicinal plants with Changbin Chen-- A plant scientist grew up in a remote area medicinal plants and their products. 2. Learn the methods of Chinese herbal classification

Weiblen, George D

343

Chinese Spacesuit Analysis  

NASA Technical Reports Server (NTRS)

In 2008, China became only the 3rd nation to perform an Extravehicular Activity (EVA) from a spacecraft. An overview of the Chinese spacesuit and life support system were assessed from video downlinks during their EVA; from those assessments, spacesuit characteristics were identified. The spacesuits were compared against the Russian Orlan Spacesuit and the U.S. Extravehicular Mobility Unit (EMU). China's plans for future missions also were presented.

Croog, Lewis

2010-01-01

344

Chinese Space Program  

NSDL National Science Digital Library

China will soon make history by sending the first Chinese man to space. Scheduled for sometime in 2003, it will be the first step toward China's highly ambitious plans for space exploration.The China National Space Administration Web site (1) has a detailed description of the country's space policy. Aerospace China, a journal published online by the administration, has information on space development plans and other issues. The history of China's space program is recounted by the online Encyclopedia Astronautica (2). Several influential scientists and their contributions to Chinese rocketry and satellite technology are highlighted. The China Academy of Launch Vehicle Technology (3) sent the first Chinese satellite into space. Its home page showcases eight launch vehicles and offers an extensive technical description of the LM-3C model. The work of various research groups at the Shanghai Astronomical Observatory (4) deals with topics ranging from satellite dynamics to stellar astronomy. Some of the groups have details of their projects and facilities online. Another observatory studies molecular clouds and star formation (5). A large collection of its research papers are provided on its Web site. A news article from Space.com (6) discusses the forthcoming launch of the Shenzhou IV spacecraft, scheduled for later this year. It is generating considerable interest, since it is said to be identical to China's first manned spacecraft, expected to launch in 2003. Another article (7) considers China's rapidly developing space program. With the tremendous effort and lofty goals for moon bases and Mars missions, the author argues that China could eventually rival the US. Many more news stories about the Chinese space program can be found on the Dragon Space Web site (8).

Leske, Cavin.

2002-01-01

345

Pericarditis and myocardial infarctions after Hodgkin's disease therapy  

SciTech Connect

From 1971 to 1984, 499 patients with all stages of Hodgkin's disease received mediastinal irradiation at the Institut Gustave-Roussy by 25 MV photons from a linear accelerator. Thirty-five pericarditis (10-year cumulative incidence rate of 9.5%) and 13 myocardial infarctions (MI) (10-year cumulative incidence rate of 3.9%) were observed. In contrast, no cases were diagnosed in a parallel series of 138 Hodgkin's disease patients treated without mediastinal irradiation during the same period of time (p less than 0.005 for pericarditis, p less than 0.05 for MI). By multivariate analysis, the role of total radiation dose given to the mediastinum and that of fraction size were evaluated, adjusting for age, sex, mediastinal involvement, and type of chemotherapy. The pericarditis risk was significantly increased with total dose greater than or equal to 41 Gy (relative risk (RR) = 3.25, p = 0.006) and with dose per fraction greater than or equal to 3.0 Gy (RR = 2.0, p = 0.06). The myocardial infarction risk was not found to be related to total dose nor to fraction size in this series, possibly because of the small number of events.

Cosset, J.M.; Henry-Amar, M.; Pellae-Cosset, B.; Carde, P.; Girinski, T.; Tubiana, M.; Hayat, M. (Department of Radiation Oncology, Institut Gustave-Roussy, Villejuif (France))

1991-07-01

346

Treatment of advanced Hodgkin's disease: EBVD versus intensive brief chemotherapy.  

PubMed

We start a controlled clinical trial to assess efficacy and toxicity of EBVD (epirubicin, bleomycin, vinblastine and dacarbazine) with an intensive and brief program of seven drugs administered weekly for 12 weeks in previously untreated patients with advanced Hodgkin's disease. Two hundred and sixty four patients were randomized to receive EBVD chemotherapy (134 cases) or intensive chemotherapy (130 cases). Eligible patients were either previously untreated stages III or IV. Patients with bulky disease received adjuvant radiotherapy. In an intent to treat analysis, all patients were evaluable for efficacy and toxicity. Complete response rate to the two regimens were similar (88 and 84%, respectively). However, actuarial 5 years overall survival rates were 87% (95% confidence interval (CI): 78-94%) for the EBVD regimen, which is statistically different to 59% (95% CI: 48-66%) for the intensive program (p < 0.01). Event-free survival were 83% (95% CI: 74-89%) for EBVD and 65% (95% CI: 58-71%) for the intensive program (p < 0.01). Significantly, more episodes of granulocytopenia grade III-IV, infection-related granulocytopenia, death-related infection even early hematological support with granulocyte colony stimulating factor were seen with the intensive, program. In the present single center trial, intensive chemotherapy did not appear to have better results when compared with standard chemotherapy in patients with advanced Hodgkin's disease. PMID:12952230

Avilés, Agustin; Cleto, Sergio; Neri, Natividad; Huerta-Guzmán, Judith; Talavera, Alejandra; Castañeda, Claudia; González, Martha

2003-08-01

347

Supradiaphragmatic Hodgkin's disease: significance of large mediastinal masses  

SciTech Connect

In order to assess the significance of large mediastinal masses in patients with Hodgkin's disease, we analyzed all patients with pathological stage (PS) IA or IIA disease evaluated and treated at Yale between 1969 and 1978. There were 131 such patients treated initially with radical radiotherapy only, combination chemotherapy being reserved for those who failed radiation. Actuarial 5 and 10 year survivals were 95%. The presence of a mediastinal mass regardless of size did not affect survival. Relapse-free survival was 77% at 5 years, 74% at 10 years in the entire group. Patients with any mediastinal involvement had a 65% relapse-free survival, 72% if the mass was < 33% of transverse chest diameter, 55% if the mass was > 33%. These differences are suggestive of a greater tendency of such patients to fail radiotherapy but the differences were not statistically significant. Patients who did fail radiotherapy were for the most part successfully retreated with combined modality therapy (chemotherapy and radiation), accounting for the most part successfully retreated with combined modality therapy (chemotherapy and radiation), accounting for the overall survival of 95%. Only 6 patients died of causes related to Hodgkin's disease and 2 of these deaths were related to combined modality therapy complications. Because of the serious potential long term consequences of combined modality treatment, it should be used with great caution and on an individual basis only in PSIA and IIA patients.

Prosnitz, L.R.; Curtis, A.M.; Knowlton, A.H.; Peters, L.M.; Farber, L.R.

1980-07-01

348

Hodgkin lymphoma masquerading as tuberculosis in a young chronic smoker.  

PubMed

Hodgkin lymphomas are malignant hemato-lymphoid neoplasms involving lymph nodes and extra-nodal sites. Bone marrow infiltration at diagnosis is uncommon, occurring in approximately 10 % cases. Such infiltration, when present, is usually focal and often associated with extensive disease, systemic symptoms, cytopenias and unfavorable histology. In the unusual event of the absence of significant peripheral lymphadenopathy, these lymphoma-related B-symptoms may easily masquerade as an infectious illness. A 30-year-old male was initially administered inappropriate anti-tubercular chemotherapy in a primary care setting for a presumptive impression of pulmonary tuberculosis. On re-evaluation due to unresponsiveness to the drugs, bulky mediastinal lymphadenopathy was detected. However, his axillary lymph node aspirate revealed epithelioid cell granulomas further confounding the picture. The correct diagnosis of Hodgkin lymphoma was finally established when a bone marrow biopsy (for fever and pancytopenia) revealed the typical neoplastic Reed Sternberg cells that were confirmed immunohistochemically. The case highlights the necessity of an early bone marrow examination in patients with unexplained fever and peripheral blood cytopenias. Physicians in tropical third-world countries with resource constraints and high disease burdens need to strike a fine balance between maintaining a high index of suspicion for tuberculosis yet being wary of the risk of missing lymphoma in such patients. PMID:25332638

Badyal, Rama Kumari; Sharma, Prashant; Prakash, Gaurav; Malhotra, Pankaj; Varma, Neelam

2014-09-01

349

Non-Hodgkin lymphomas in pregnancy: tackling therapeutic quandaries.  

PubMed

Hodgkin lymphoma (HL) and non-Hodgkin lymphoma (NHL) often present with systemic symptoms such as fatigue, shortness of breath and night sweats, mimicking pregnancy-related features which may result in delayed disease diagnosis. Furthermore, the wish to avoid investigational imaging, aiming to protect the fetus from radiation exposure, may lead to a further delay, which does not often result in significant changes in HL clinical nature and patient outcome. In contrast, a more aggressive behavior (i.e., advanced disease stage and reproductive organ involvement) of most NHL types diagnosed in pregnancy may require urgent therapeutic intervention to prevent disease progression. Current management of pregnancy-associated NHL depends on histological subtype of the disease, gestational stage at diagnosis and the urgency of treatment for a specific patient. Patients diagnosed with indolent lymphoma may often be just followed, whereas those presenting with aggressive or highly aggressive disease need to be urgently treated with chemoimmunotherapy, either after undergoing an elective pregnancy termination if diagnosed at an early gestational stage, or with pregnancy preservation, if diagnosed later. Supportive care of NHL is also important; however, granulocyte colony stimulating factor (G-CSF) which is commonly used outside of pregnancy, should be cautiously employed, considering its established teratogenicity in animals, though this is less proven in humans. In conclusion, given the paucity of studies prospectively evaluating the outcome of pregnant women with NHL, international efforts are warranted to elucidate critical issues and develop guidelines for the management of such patients. PMID:25108745

Avivi, Irit; Farbstein, Dan; Brenner, Benjamin; Horowitz, Netanel A

2014-09-01

350

Plasma Biomarkers for Detecting Hodgkin's Lymphoma in HIV Patients  

SciTech Connect

The lifespan of AIDS patients has increased as a result of aggressive antiretroviral therapy, and the incidences of the AIDS-defining cancers, Hodgkin's lymphoma and Kaposi sarcoma, are declining, Still, the increased longevity of AIDS patients is now associated with increased incidence of other cancers, including Hodgkin's lymphoma (HL). In order to determine if we could identify biomarkers for the early detection of HL, we undertook an accurate mass and elution time tag proteomics analysis of individual plasma samples from AIDS patients without HL (n=14) and with HL (n=22). This analysis identified 33 proteins, included C-reactive protein and three serum amyloid proteins, that were statistically (p<0.05) altered by at least 1.5-fold between the two groups. At least three of these proteins have previously been reported to be altered in the blood of HL patients. Ingenuity Pathway Analysis software identified 'inflammatory response' and 'cancer' as the top two, biological functions commonly associated with these proteins. The clear association of these proteins with cancer and inflammation suggests that they are truly associated with HL and that they would be useful in the detection of this disease.

Varnum, Susan M.; Webb-Robertson, Bobbie-Jo M.; Hessol, Nancey; Smith, Richard D.; Zangar, Richard C.

2011-12-16

351

Classic-Ada(TM)  

NASA Technical Reports Server (NTRS)

The SPS product, Classic-Ada, is a software tool that supports object-oriented Ada programming with powerful inheritance and dynamic binding. Object Oriented Design (OOD) is an easy, natural development paradigm, but it is not supported by Ada. Following the DOD Ada mandate, SPS developed Classic-Ada to provide a tool which supports OOD and implements code in Ada. It consists of a design language, a code generator and a toolset. As a design language, Classic-Ada supports the object-oriented principles of information hiding, data abstraction, dynamic binding, and inheritance. It also supports natural reuse and incremental development through inheritance, code factoring, and Ada, Classic-Ada, dynamic binding and static binding in the same program. Only nine new constructs were added to Ada to provide object-oriented design capabilities. The Classic-Ada code generator translates user application code into fully compliant, ready-to-run, standard Ada. The Classic-Ada toolset is fully supported by SPS and consists of an object generator, a builder, a dictionary manager, and a reporter. Demonstrations of Classic-Ada and the Classic-Ada Browser were given at the workshop.

Valley, Lois

1989-01-01

352

Women in Classical Antiquity  

NSDL National Science Digital Library

This site illustrates the successful integration of the Internet into university courses. Professor Barbara Goff of the Department of Classics at UT-Austin created Women in Classical Antiquity to accompany her Spring 1998 course. The site offers an assignments listing, bibliography, readings list, an excellent selection of study questions, and paper guidelines.

353

Chinese herb nephropathy  

PubMed Central

In 1994, a 44-year-old woman progressed from normal renal function to advanced renal failure and end-stage renal disease within 8 months. Biopsy revealed extensive interstitial fibrosis with focal lymphocytic infiltration. She received a cadaveric renal transplant in January 1996 and had an uneventful posttransplant course. As a result of a minor motor vehicle accident, the patient had received acupuncture and Chinese herbal medicine for pain relief approximately 5 months before the onset of renal symptoms. After the transplant, analysis of the herbal remedies clearly indicated the presence of aristolochic acid in 2 of the 6 Chinese herbs ingested. Ingestion of aristolochic acid has been linked to a newly defined entity, Chinese herb nephropathy (CHN). This article discusses the history of CHN and its implication in the current case and in other recent similar cases and makes recommendations to avoid future problems caused by unregulated use of herbal medicines. This is the first reported case of CHN in the USA. PMID:16389336

2000-01-01

354

The classical Schrödinger equation  

E-print Network

Using a simple geometrical construction based upon the linear action of the Heisenberg--Weyl group we deduce a new nonlinear Schr\\"{o}dinger equation that provides an exact dynamic and energetic model of any classical system whatsoever, be it integrable, nonintegrable or chaotic. Within our model classical phase space points are represented by equivalence classes of wavefunctions that have identical position and momentum expectation values. Transport of these equivalence classes without dispersion leads to a system of wavefunction dynamics such that the expectation values track classical trajectories {\\em precisely\\/} for arbitrarily long times. Interestingly, the value of $\\hbar$ proves immaterial for the purpose of constructing this alternative representation of classical point mechanics. The new feature which $\\hbar$ does mediate concerns a simple embedding of the quantum geometric phase within classical mechanics. We discuss problems of physical interpretation and discover a simple route to recover the ordinary linear Schr\\"{o}dinger equation.

K. R. W. Jones

2014-05-24

355

Fermions from classical statistics  

SciTech Connect

We describe fermions in terms of a classical statistical ensemble. The states {tau} of this ensemble are characterized by a sequence of values one or zero or a corresponding set of two-level observables. Every classical probability distribution can be associated to a quantum state for fermions. If the time evolution of the classical probabilities p{sub {tau}} amounts to a rotation of the wave function q{sub {tau}}(t)={+-}{radical}(p{sub {tau}}(t)), we infer the unitary time evolution of a quantum system of fermions according to a Schroedinger equation. We establish how such classical statistical ensembles can be mapped to Grassmann functional integrals. Quantum field theories for fermions arise for a suitable time evolution of classical probabilities for generalized Ising models.

Wetterich, C., E-mail: c.wetterich@thphys.uni-heidelberg.d [Institut fuer Theoretische Physik, Universitaet Heidelberg, Philosophenweg 16, D-69120 Heidelberg (Germany)

2010-12-15

356

Fermions from classical statistics  

E-print Network

We describe fermions in terms of a classical statistical ensemble. The states $\\tau$ of this ensemble are characterized by a sequence of values one or zero or a corresponding set of two-level observables. Every classical probability distribution can be associated to a quantum state for fermions. If the time evolution of the classical probabilities $p_\\tau$ amounts to a rotation of the wave function $q_\\tau(t)=\\pm \\sqrt{p_\\tau(t)}$, we infer the unitary time evolution of a quantum system of fermions according to a Schr\\"odinger equation. We establish how such classical statistical ensembles can be mapped to Grassmann functional integrals. Quantum field theories for fermions arise for a suitable time evolution of classical probabilities for generalized Ising models.

C. Wetterich

2010-07-21

357

SB-715992 in Treating Patients With Metastatic or Unresectable Solid Tumors or Hodgkin's or Non-Hodgkin's Lymphoma  

ClinicalTrials.gov

Adult Grade III Lymphomatoid Granulomatosis; Extranodal Marginal Zone B-cell Lymphoma of Mucosa-associated Lymphoid Tissue; Nodal Marginal Zone B-cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Diffuse Mixed Cell Lymphoma; Recurrent Adult Diffuse Small Cleaved Cell Lymphoma; Recurrent Adult Grade III Lymphomatoid Granulomatosis; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Immunoblastic Large Cell Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Splenic Marginal Zone Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Diffuse Mixed Cell Lymphoma; Stage IV Adult Diffuse Small Cleaved Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Immunoblastic Large Cell Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Grade 3 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Unspecified Adult Solid Tumor, Protocol Specific; Waldenström Macroglobulinemia

2013-01-11

358

Chinese Library Services to a Predominantly Chinese-Speaking Community.  

ERIC Educational Resources Information Center

The San Francisco Public Library has developed some special services for Chinese-speaking patrons. A collection of Chinese materials at the Chinatown branch now contains 9,000 fiction and non-fiction books, 9 newspapers, 19 periodicals, and over 300 phonograph records. Bilingual citizenship books are provided, as are reference books on China and…

Chan, Stella W.

359

Acoustical study of classical Peking Opera singing.  

PubMed

Acoustic characteristics of classical opera singing differ considerably between the Western and the Chinese cultures. Singers in the classical Peking opera tradition specialize on one out of a limited number of standard roles. Audio and electroglottograph signals were recorded for four performers of the Old Man role and three performers of the Colorful Face role. Recordings were made of the singers' speech and when they sang recitatives and songs from their roles. Sound pressure level, fundamental frequency, and spectrum characteristics were analyzed. Histograms showing the distribution of fundamental frequency showed marked peaks for the songs, suggesting a scale tone structure. Some of the intervals between these peaks were similar to those used in Western music. Vibrato rate was about 3.5Hz, that is, considerably slower than in Western classical singing. Spectra of vibrato-free tones contained unbroken series of harmonic partials sometimes reaching up to 17 000Hz. Long-term-average spectrum (LTAS) curves showed no trace of a singer's formant cluster. However, the Colorful Face role singers' LTAS showed a marked peak near 3300Hz, somewhat similar to that found in Western pop music singers. The mean LTAS spectrum slope between 700 and 6000Hz decreased by about 0.2dB/octave per dB of equivalent sound level. PMID:21621380

Sundberg, Johan; Gu, Lide; Huang, Qiang; Huang, Ping

2012-03-01

360

Classical Mythology Directory  

NSDL National Science Digital Library

Created by Dr. Robin Mitchell-Boyask, Professor in the Department of Greek, Hebrew, and Roman Classics at Temple University, this site is primarily intended for students enrolled in the Dr. Mitchell-Boyask's summer or fall 2002 Classical Mythology course. However, the site provides a host of information on classical mythology and would be useful to anyone studying and/or interested in this area of specialization. Not only does the site contain study guides, which could be valuable material for English teachers, but it also contains information on the myths of Rome and Athens, numerous paintings and sculptures, as well as many links to other relevant sites.

Mitchell-Boyask, Robin, 1961-.

361

The Commoditization of Chinese Women.  

ERIC Educational Resources Information Center

Documents women's historically low place in Chinese culture as an integral part of a complex economic pattern. Covers the following topics: (1) women, family, and economy; (2) the Chinese modes of production; (3) views of commodity production in China; (4) class relations; (5) women's labor; and (6) textiles, women, and class. (JS)

Gates, Hill

1989-01-01

362

The Anxiety of Chinese Students.  

ERIC Educational Resources Information Center

In order to better understand and counsel Chinese students in the United States, the trait anxiety and test anxiety of 67 Chinese graduate students in education attending two universities in Taiwan were measured. Normative assessments for the total group showed that the sample fell within the normal range of U.S. students as defined in Test…

MacDougall, Mary Ann; Corcoran, Miriam D.

363

A Chinese Zodiac Mathematical Structure.  

ERIC Educational Resources Information Center

Helps students identify the animal that corresponds to the year of their birth according to the Chinese zodiac. Defines the structure of the Chinese zodiac so that the subsets of compatibles and opposites form closed substructures with interesting mathematical properties. (ASK)

Lamb, John F., Jr.

2000-01-01

364

Chinese Converstations: An Intellectual Profile.  

ERIC Educational Resources Information Center

A profile of how Chinese urban intellectuals view life in their country is presented. Information was obtained through many conversations with Chinese educators and students during the author's visit to China. Discussed are family, education, the cultural revolution, the Gang of Four, the quest for modernization, and the policy toward…

Cogan, John J.

1980-01-01

365

Primary anorectal Hodgkin lymphoma: report of a case and review of the literature.  

PubMed

Primary colorectal lymphomas are very rare. They are mostly B-cell non-Hodgkin lymphomas. Only 2 cases of anorectal Hodgkin lymphoma have been described so far, both affecting HIV-infected males and showing Epstein-Barr virus infection. We report an unusual case of primary Hodgkin lymphoma of the anorectal region in an HIV-negative, Epstein-Barr virus-infected patient and in the absence of inflammatory bowel disease. The importance of distinguishing Hodgkin lymphoma from Epstein-Barr virus-induced lymphoproliferative disorders and from Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly is stressed in particular in non-immunocompromised patients and in the absence of history of inflammatory bowel disease. PMID:24440095

Ambrosio, Maria Raffaella; Rocca, Bruno Jim; Barone, Aurora; Mastrogiulio, Maria Grazia; Costa, Aurelio; Bellan, Cristiana; Lazzi, Stefano

2014-03-01

366

Stanford study identifies early-life risk factors for non-Hodgkin lymphoma  

Cancer.gov

Factors influencing early life non-Hodgkin lymphoma (NHL) incidence include family characteristics, high fetal growth, older maternal age, low birth order, and male gender, according to a study published May 22 in the Journal of the National Cancer Institute.

367

Soft-tissue masses as presentation of non-Hodgkin's lymphoma in AIDS patients*  

PubMed Central

Primary soft tissue Non-Hodgkin lymphomas are very rare and account only for 0.1 % of the cases. Generally, Non-Hodgkin lymphomas of the soft tissue present as large subcutaneous masses without evidence of nodal or skin involvement. We describe four cases of primary Non-Hodgkin lymphomas of the soft tissue in patients infected with the human immunodeficiency virus. The most common site of involvement was the chest wall in all the patients; histopathological and immunophenotypic examination of the biopsy smears revealed two cases of plasmablastic lymphomas, one Burkitt and one diffuse large B-cell lymphoma. Non-Hodgkin lymphomas should be included in the differential diagnosis of soft tissue masses in human immunodeficiency virus - seropositive patients. PMID:24068141

Corti, Marcelo; Villafañe, María Florencia; Bistmans, Alicia; Campitelli, Ana; Narbaitz, Marina

2013-01-01

368

Obatoclax and Bortezomib in Treating Patients With Aggressive Relapsed or Recurrent Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Non-Hodgkin Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Grade 3 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma

2013-05-01

369

JEB Classics JJEEBBCCllaassssiiccss  

E-print Network

, discuss each classic paper's impact on the field of biology and their own work. A PDF of the original, biorobotics, and diving physiology. The Gray's Paradox controversy resulted from the first attempt to evaluate

Fish, Frank

370

Multiagent classical planning   

E-print Network

Classical planning problems consist of an environment in a predefined state; a set of deterministic actions that, under certain conditions, change the state of the environment; and a set of goal conditions. A solution ...

Crosby, Matthew David

2014-06-27

371

Classical confined particles  

NASA Technical Reports Server (NTRS)

An alternative picture of classical many body mechanics is proposed. In this picture particles possess individual kinematics but are deprived from individual dynamics. Dynamics exists only for the many particle system as a whole. The theory is complete and allows to determine the trajectories of each particle. It is proposed to use our picture as a classical prototype for a realistic theory of confined particles.

Horzela, Andrzej; Kapuscik, Edward

1993-01-01

372

Dana-Farber study finds blood levels of immune protein predict risk in Hodgkin disease  

Cancer.gov

Blood levels of an immunity-related protein, galectin-1, in patients with newly diagnosed Hodgkin lymphoma reflected the extent of their cancer and correlated with other predictors of outcome, scientists reported at the American Society of Hematology annual meeting. In a study of 315 patients from a German database, researchers from Dana-Farber Cancer Institute found that serum galectin-1 levels "are significantly associated with tumor burden and additional adverse clinical characteristics in newly diagnosed Hodgkin lymphoma (HL) patients."

373

Epstein-Barr Virus Latent Membrane Protein Expression in Hodgkin and Reed Sternberg Cells  

Microsoft Academic Search

Cryostat sections from lymph nodes of 47 Hodgkin disease patients were examined by immunohistology for the Epstein-Barr virus (EBV)-encoded latent membrane protein (LMP), nuclear antigen 2, and late viral glycoprotein gp350\\/250. A distinct LMP-specific membrane and cytoplasmic staining was detected exclusively in Hodgkin and Reed-Sternberg cells in 18 patients (38%); EBV nuclear antigen 2 and gp350\\/250 immunoreactivity was absent in

Hermann Herbst; Friederike Lymphomas; Michael Hummel; Gerald Niedobitek; Stefano Pileri; Nikolaus Muller-Lantzsch; Harald Stein; Malignant Lymphomas; Oncogenes; Immunohistology

1991-01-01

374

Hodgkin's disease with leptomeningeal involvement. Report of a case with long survival  

SciTech Connect

A 30-year-old white man with Stage IV B Hodgkin's disease, mixed cellularity type, developed leptomeningeal involvement shortly after relapsing on nitrogen mustard, Oncovin (vincristine), procarbazine, and prednisone (MOPP), and while receiving Adriamycin (doxorubicin), bleomycin, Velban (vinblastine), and dacarbazine (ABVD). Whole brain irradiation and intrathecal methotrexate were successfully incorporated into his treatment program. The patient has now been in complete remission for more than 40 months. A review of this rare complication of Hodgkin's disease is presented.

Orlowski, E.P.; Hansen, R.M.; Anderson, T.; Hanson, G.A.; Kun, L.E.; Pisciotta, A.V.

1984-05-01

375

Occupational Exposure to Pesticides and Risk of Non-Hodgkin's Lymphoma  

Microsoft Academic Search

Pesticide exposure may be a risk factor for non-Hodgkin's lymphoma, but it is not certain which types of pesticides are involved. A population-based case-control study was undertaken in 2000-2001 using detailed methods of assessing occupational pesticide exposure. Cases with incident non-Hodgkin's lymphoma in two Australian states (n ¼ 694) and controls (n ¼ 694) were chosen from Australian electoral rolls.

L. Fritschi; G. Benke; A. M. Hughes; A. Kricker; J. Turner; C. M. Vajdic; A. Grulich; S. Milliken; J. Kaldor; B. K. Armstrong

2005-01-01

376

Cranio-maxillofacial non-Hodgkin’s lymphoma: Clinical and histological presentation  

Microsoft Academic Search

Non-Hodgkin’s lymphoma represents about 5% of all malignant lesions of the head and neck. In this study we retrospectively evaluated clinical presentation, histological subtype and long-term prognosis of 42 patients with non-Hodgkin’s lymphoma involving the craniofacial area. The mean age at diagnosis was 64years. More than half of the patients presented with disseminated disease at multiple sites (55%, n=23). In

Sebastian Scherfler; Kolja Freier; Robin Seeberger; Claire Bacon; Jürgen Hoffmann; Oliver C. Thiele

377

Role of Hematopoietic Stem Cell Transplantation in the Treatment of Non-Hodgkin’s Lymphoma  

Microsoft Academic Search

In 2007 it is estimated that there will be more than 63,000 new cases of nonHodgkin’s lymphoma (NHL) in the United States and that nearly 19,000 people will die from NHL. Non-Hodgkin’s lymphoma accounts for approximately 4% of all new cancer diagnoses. The NHL incidence rate increased more than 50% between 1975 and the early 1990s, although this increase has

Philip J. Bierman; Gordon L. Phillips

378

[Male secondary breast cancer after treatment for Hodgkin's disease. Case report and review of the literature].  

PubMed

Hodgkin's disease is now curable in more than 50% of cases, due to its chemo- and radio-sensitivity. However, treatment exposes to a risk of secondary cancer varying from 1 to 10% depending on chemoradiotherapy doses and schedules. We report a case of secondary breast cancer associated with a secondary thyroid cancer observed in a 24-year-old man treated when he was 13 years old by vinblastin and radiation for stage IIA, a Hodgkin's disease. PMID:11191854

Boussen, H; Kochbati, L; Besbes, M; Dhiab, T; Makhlouf, R; Jerbi, G; Gamoudi, A; Benna, F; Rahal, K; Maalej, M; Ben Ayed, F

2000-01-01

379

Bilateral primary adrenal non-Hodgkin's lymphoma without adrenal insufficiency.  

PubMed

We are presenting a rare case of bilateral adrenal non-Hodgkin's lymphoma (NHL) that presented as a primary malignancy. An 83-year-old man presented with newly discovered bilateral adrenal incidentalomas, fatigue, and 30 pound weight loss. Of the 116 cases of primary adrenal NHL reported, over half have presented bilaterally and occur with adrenal insufficiency. Therefore, the finding of bilateral adrenal masses requires an urgent work-up of the functional status of the adrenal gland as well as a thorough analysis of the imaging characteristics seen on noncontrast computed tomography (CT) in order to maximize patient survival. Adrenal function testing was normal. Repeat CT imaging revealed rapidly growing lesions with high attenuations; both masses >10 HU. Histological examination of core biopsies discovered malignant lymphoma with no known past history of lymphoma. Our case coincides with the literature, which states that a mass with attenuation >10 HU in the adrenal glands has a high risk of malignancy. PMID:25837497

Simpson, William Greg; Babbar, Paurush; Payne, Lynnetta Faith

2015-01-01

380

Hematopoietic stem cell transplantation for non-Hodgkin lymphoma.  

PubMed

Up-front rituximab-based chemotherapy has improved outcomes in non-Hodgkin lymphoma (NHL); refractory or relapsed NHL still accounts for approximately 18,000 deaths in the United States. Autologous hematopoietic stem cell transplantation (SCT) can improve survival in primary refractory or relapsed aggressive NHL and mantle cell lymphoma and in relapsed follicular or peripheral T-cell lymphoma. Autologous SCT as a consolidation therapy after first complete or partial remission in high-risk aggressive NHL, mantle cell lymphoma, and peripheral T-cell lymphoma may improve progression-free survival. Allogeneic SCT offers a lower relapse rate but a higher nonrelapse mortality resulting in overall survival similar to autologous SCT. PMID:25459180

Bhatt, Vijaya Raj; Vose, Julie M

2014-12-01

381

[Hodgkin disease of the nasopharynx: report of three cases].  

PubMed

We report three cases of Hodgkin's disease (HD) involving the nasopharynx. Their clinical presentations, morphological and immunohistochimical features and their therapy modalities are discussed. The patients were aged 36, 41 and 77, presenting with increasing bilateral nasal obstruction in one case and a cervical mass in the two others. Histological study showed mixed cellularity type of HD in all cases. The Reed Sternberg cells expressed both of CD15 and CD30 in one case, and only one of them in the other cases. In one case, LMP1 was detected, CD20 and CD3 were not. HD of nasopharynx should be differentiated from EBV-associated lymphoproliferations. The treatment is based on radiotherapy that can be associated to neoadjuvant chemotherapy if nodes are involved. PMID:16309942

Kochbati, L; Chraïet, N; Nasr, C; Boussen, H; Touati, S; Ben Romdhane, K; Maalej, M

2006-05-01

382

Spontaneous spiking in an autaptic Hodgkin-Huxley set up  

E-print Network

The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish not only connections to neighboring cells but as well to its own axon. The biophysical modeling is achieved in terms of a stochastic Hodgkin-Huxley model containing such a built in delayed feedback. The fluctuations stem from intrinsic channel noise, being caused by the stochastic nature of the gating dynamics of ion channels. The influence of the delayed stimulus is systematically analyzed with respect to the coupling parameter and the delay time in terms of the interspike interval histograms and the average interspike interval. The delayed feedback manifests itself in the occurrence of bursting and a rich multimodal interspike interval distribution, exhibiting a delay-induced reduction of the spontaneous spiking activity at characteristic frequencies. Moreover, a specific frequency-locking mechanism ...

Li, Yunyun; Hanggi, Peter; Schimansky-Geier, Lutz

2010-01-01

383

Multivariate analysis of prognostic factors in early stage Hodgkin's disease  

SciTech Connect

A multivariate analysis of the prognostic factors was carried out with a Cox model on 1,139 patients with clinical Stage I + II Hodgkin's disease included in three controlled clinical trials. The following indicators had been prospectively registered: aged, sex, systemic symptoms, erythrocyte sedimentation, results of staging laparotomy when performed, as well as the date and type of treatment. A linear logistic analysis showed that most of the indicators are interrelated. This emphasizes the necessity of a multivariate analysis in order to assess the independent influence of each of them. The two main prognostic indicators for relapse-free survival are systemic symptoms and/or ESR and number of involved areas. The only significant factor for survival after relapse is age. Sex has a small but significant influence on relapse-free survival. The relative influence of each indicator varies with the type of treatment and these variations may help in understanding the biologic significance of the indicators.

Tubiana, M.; Henry-Amar, M.; van der Werf-Messing, B.; Henry, J.; Abbatucci, J.; Burgers, M.; Hayat, M.; Somers, R.; Laugier, A.; Carde, P.

1985-01-01

384

Tsukamurella inchonensis infection in a child with Hodgkin's lymphoma.  

PubMed

Tsukamurella spp. infection is a rare but important cause of bacteremia in immunocompromised patients. The organism is an aerobic, Gram-positive, weakly acid-fast bacillus that is difficult to differentiate from other aerobic Actinomycetales by standard laboratory methods. Here, we report on the case of a 14-year-old patient with Hodgkin's lymphoma who, after intensive chemotherapy, developed Tsukamurella inchonensis bacteremia, which was identified on the peripherally inserted central venous catheter (PICC) using 16S rRNA sequencing analysis. The bacteremia was successfully controlled with antimicrobial therapy and subsequent removal of the PICC. This is the first report of bacteremia by Tsukamurella inchonensis in immunocompromised children. Careful observation and prompt analysis of opportunistic infection, including Tsukamurella spp., is very important in immunocompromised children. PMID:25711272

Ochi, Fumihiro; Tauchi, Hisamichi; Moritani, Kyoko; Miyamoto, Hitoshi; Ohkusu, Kiyofumi; Ishii, Eiichi

2015-02-01

385

Treatment selection for stage IIIA Hodgkin's disease patients  

SciTech Connect

Two treatment policies for the therapy of patients with Stage IIIA Hodgkin's disease are compared. From 1969-1976, 49 newly diagnosed and pathologically staged IIIA patients received total nodal irradiation (TNI) alone (no liver irradiation). Although actuarial survival was 80% at 5 years and 68% at 10 years, actuarial freedom from relapse was only 38% at 5 years. Accordingly, a new treatment policy was instituted in 1976. Patients with either CS IIIA disease, multiple splenic nodules, IIIA with a large mediastinal mass or III/sub 2/, received combined modality therapy (combination chemotherapy and irradiation). All others received TNI. Thirty-six patients have been treated under the new program. The actuarial survival is 90% at 5 years and the relapse-free survival is 87%, suggesting the superiority of this approach. Complications from the treatments are discussed.

Prosnitz, L.R.; Cooper, D.; Cox, E.B.; Kapp, D.S.; Farber, L.R.

1985-08-01

386

Hepatitis viruses and non-Hodgkin’s lymphoma: A review  

PubMed Central

Non-Hodgkin’s lymphoma (NHL) is among the haematological malignancies with high prevalence worldwide, causing estimated 355?900 new cases and 191?400 deaths in 2008. High prevalence of NHL is documented in economically more developed areas while low prevalence is observed in less developed areas of the globe. A wide array of environmental factors have been reported to be either directly involved or in modifying the risk of NHL development. In addition to these factors, a number of infectious agents, chiefly viruses have also been implicated in the development of NHL. This article reviews the available literature to discuss the role of hepatitis viruses in NHL development, possible mechanisms of lymphomagenesis and also identify the areas in which further research is required to better understand this disease. A brief discussion on the clinical aspects such as classification, staging, treatment approaches have also been included in this article. PMID:24175222

Datta, Sibnarayan; Chatterjee, Soumya; Policegoudra, Rudragoud S; Gogoi, Hemant K; Singh, Lokendra

2012-01-01

387

Hodgkin Disease—An Ever-Evolving Therapy  

PubMed Central

Therapy of Hodgkin lymphoma (HL) is a rapidly changing field due to plenty of currently emerging data. Treatment approaches are currently based on tailoring of therapy in order to achieve a maximal response with minimal toxicity. Since the median age of HL patients is 33 years and their prospective life expectancy of another half a century, a major emphasis needs to be put on dramatic reduction of later toxicity. The assessment of the treatment effect should be based not only on progression-free survival, but should include evaluation of cardiac toxicity, secondary neoplasms, and fertility in the long-term follow-up. The ancient principle “first do no harm” should be central in HL therapy. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. PMID:25386345

Dann, Eldad J.

2014-01-01

388

Hodgkin disease-an ever-evolving therapy.  

PubMed

Therapy of Hodgkin lymphoma (HL) is a rapidly changing field due to plenty of currently emerging data. Treatment approaches are currently based on tailoring of therapy in order to achieve a maximal response with minimal toxicity. Since the median age of HL patients is 33 years and their prospective life expectancy of another half a century, a major emphasis needs to be put on dramatic reduction of later toxicity. The assessment of the treatment effect should be based not only on progression-free survival, but should include evaluation of cardiac toxicity, secondary neoplasms, and fertility in the long-term follow-up. The ancient principle "first do no harm" should be central in HL therapy. Completion of ongoing and currently initiated trials could elucidate multiple issues related to the management of HL patients. PMID:25386345

Dann, Eldad J

2014-10-01

389

Bilateral primary adrenal non-Hodgkin's lymphoma without adrenal insufficiency  

PubMed Central

We are presenting a rare case of bilateral adrenal non-Hodgkin's lymphoma (NHL) that presented as a primary malignancy. An 83-year-old man presented with newly discovered bilateral adrenal incidentalomas, fatigue, and 30 pound weight loss. Of the 116 cases of primary adrenal NHL reported, over half have presented bilaterally and occur with adrenal insufficiency. Therefore, the finding of bilateral adrenal masses requires an urgent work-up of the functional status of the adrenal gland as well as a thorough analysis of the imaging characteristics seen on noncontrast computed tomography (CT) in order to maximize patient survival. Adrenal function testing was normal. Repeat CT imaging revealed rapidly growing lesions with high attenuations; both masses >10 HU. Histological examination of core biopsies discovered malignant lymphoma with no known past history of lymphoma. Our case coincides with the literature, which states that a mass with attenuation >10 HU in the adrenal glands has a high risk of malignancy.

Simpson, William Greg; Babbar, Paurush; Payne, Lynnetta Faith

2015-01-01

390

Reversible methotrexate associated lymphoproliferative disease evolving into Hodgkin's disease.  

PubMed

We describe a case of nodular sclerosing Hodgkin's disease (NSHD) developing in a 61-year-old woman with seropositive rheumatoid arthritis treated with oral methotrexate (MTX) 5 to 15 mg/week for 5 years. Computed tomography (CT) of the abdomen revealed splenomegaly and marked abdominal and retroperitoneal lymphadenopathy. MTX was discontinued; several weeks later prednisone 10 mg/day was added to control worsening polyarthralgia. Repeat CT at 3 months showed almost complete regression of the splenomegaly and lymphadenopathy. However, CT studies at 10 months showed asymptomatic progression of lymphadenopathy, which on biopsy revealed NSHD. Patients with apparently reversible MTX associated lymphoproliferative disorder require periodic monitoring for asymptomatic development of malignant lymphoma. PMID:10743830

Moseley, A C; Lindsley, H B; Skikne, B S; Tawfik, O

2000-03-01

391

An adult patient with Nijmegen Breakage Syndrome and Hodgkin's Lymphoma  

PubMed Central

Background Nijmegen Breakage Syndrome (NBS) is a rare autosomal recessive DNA repair disorder characterized by immune deficiency, microcephaly, mental retardation and a disposition for the development of hematological malignancies. So far, mostly pediatric patients have been described, since the underlying condition is often fatal before adulthood. Many patients diagnosed with Hodgkin lymphoma (HL) due to this DNA repair defect receive reduced treatment followed by early progression and fatal outcome. Case presentation We describe here a 26-year old male caucasian patient with NBS who presented with multi organ failure due to HL. Immediate intensive chemotherapy lead to complete remission and reversed organ failure. Conclusion We show that application of standard chemotherapy can lead to long-term disease free survival in patients with a DNA repair disorder. Furthermore, we describe here, to the best of our knowledge, the first adult patient with NBS and HL. PMID:24428841

2014-01-01

392

Reproductive factors and non-Hodgkin lymphoma: a systematic review.  

PubMed

Considerable efforts have been made to elucidate non-Hodgkin lymphoma's (NHL) etiology during the last decades. Some evidence points to an association with reproductive factors, as incidence rates for most NHL subtypes are usually higher in men than in women, and several subtypes express hormonal receptors. Although the evidence is not compelling, some studies show an inverse association with gravidity. Associations with postmenopausal hormone therapy are usually derived from unopposed estrogen use, rather than for the combination of estrogen with progestin, but these findings vary by study design. Inconsistencies in the results are likely due to the complex relationship between reproductive, biological, and sociodemographic factors, as well as to study limitations. Elucidating the role of hormonal factors should provide clues for therapeutic options and public health decisions. We provide an overview of the available evidence on reproductive factors in NHL etiology, underscoring potential sources of discrepancies and bias. PMID:25132165

Costas, Laura; de Sanjosé, Silvia; Infante-Rivard, Claire

2014-12-01

393

Thyroid function after mantle irradiation in Hodgkin's disease  

SciTech Connect

The thyroid function of 64 patients with Hodgkin's disease who received mantle irradiation during the period 1966 to 1976 was studied. More than two-thirds (44 to 64) had some thyroid dysfunction. Twenty had mild dysfunction manifested by an abnormal thyroid-stimulating hormone response to thyrotropin-releasing hormone. Twenty had what could be termed compensated hypothyroidism while four were overtly hypothyroid. The severity of dysfunction was not related to age, sex, or chemotherapy. We found, however, that decreased thyroid function was inversely proportional to the length of time between a diagnostic lymphangiogram and the radiation therapy. These results are consistent with the hypothesis that the iodine load of the lymphangiogram renders the thyroid gland more radiosensitive. Thyroxine suppression of the thyroid gland during the period from the lymphangiogram through the termination of radiation therapy is suggested as a means of avoiding thyroid injury.

Smith, R.E. Jr.; Adler, R.A.; Clark, P.; Brinck-Johnsen, T.; Tulloh, M.E.; Colten, T.

1981-01-02

394

State of the art in the treatment of Hodgkin lymphoma.  

PubMed

Hodgkin lymphoma (HL) has become one of the most easily curable malignancies in oncology. More than 80% of patients can be cured with risk-adapted treatment that includes chemotherapy and radiotherapy. This progress is mainly due to the development of multi-agent chemotherapy and improved radiation techniques; however, severe, life-threatening treatment-related side effects occur, which include organ toxicity and secondary malignancies. Thus, the treatment approaches must be carefully balanced between optimal disease control and the risk of long-term sequelae. Although this article is meant to provide an overview of the current treatment approaches for patients with HL, in many instances conflicting results from various clinical trials are available, and a personal judgment is inevitable. Here, we focus on evidence from large clinical trials with solid conclusions. PMID:22688578

Borchmann, Peter; Eichenauer, Dennis A; Engert, Andreas

2012-08-01

395

Current Role of Autologous and Allogeneic Stem Cell Transplantation for Relapsed and Refractory Hodgkin Lymphoma  

PubMed Central

Classical Hodgkin lymphoma (cHL) is a relatively rare disease, with approximately 9,200 estimated new cases and 1,200 estimated deaths per year in the United States. First-line chemo-radiotherapy leads to cure rates approaching 80% in patients with advanced-stage disease. However, 25 to 30% of these patients are not cured with chemotherapy alone (i.e., the ABVD regimen) and show either primary refractoriness to chemotherapy, early disease relapse or late disease relapse. Second-line salvage high-dose chemotherapy (HDC) and autologous stem cell transplantation (SCT) have an established role in the management of refractory/relapsed cHL, leading to durable responses in approximately 50% of relapsed patients and a minority of refractory patients. However, due to the poor responses to second-line salvage chemotherapy and dismal long-term disease control of primary refractory and early relapsed patients, their treatment represents an unmet medical need. Allogeneic SCT represents, by far, the only strategy with a curative potential for these patients; however, as discussed in this review, it’s role in cHL remains controversial. Despite a general consensus that early relapsed and primary refractory patients represent a clinical challenge requiring effective treatments to achieve long-term disease control, there has been no consensus on the optimal therapy that should be offered to these patients. This review will briefly discuss the clinical results and the main issues regarding autologous SCT as well as the current role of allogeneic SCT. PMID:25745542

Castagna, Luca; Carlo-Stella, Carmelo; Mazza, Rita; Santoro, Armando

2015-01-01

396

CHINESE DANCE CLASSES CICM 303 (008) CHINESE FOLK DANCE FOR CHILDREN  

E-print Network

CHINESE DANCE CLASSES CICM 303 (008) CHINESE FOLK DANCE FOR CHILDREN (Grades K-5) CICM 404 (007) CHINESE FOLK DANCE FOR CHILDREN (Grades 3-12) Jan.17­Apr.25 Saturdays11:30 am­12:30pm Jan.17­Apr.25 CHINESE ART CLASSES CICC 112 (002) BEGINNING CHINESE CALLIGRAPHY & PAINTING FOR CHILDREN (Ages 5-9) CICC

Powers, Robert

397

Pediatric pulmonary hodgkin lymphoma: Analysis of 10 years data from a single center  

PubMed Central

Several reports indicate that lungs are the extralymphatic site most commonly affected in patients with Hodgkin lymphoma; however, the data in children are rather limited. This retrospective study aimed to assess the frequency, clinical picture, and the impact on prognosis in children with pulmonary Hodgkin lymphoma, who were diagnosed and treated in a single center during a 10-year period. Pulmonary lesions related to HL: nodules and parenchymal infiltrates with cavitations were found in 3 of 32 (9.4%) patients; in 2 cases these were found as the concomitant manifestation whereas in 1 case as the solitary form (Primary Pulmonary Hodgkin Lymphoma). B-DOPA and MVPP chemotherapy combined with mediastinal and pulmonary irradiation resulted in sustained remissions in all 3 patients, lasting 3, 7, and 64 months, respectively. Lung involvement occurs in up to 10% of children with Hodgkin lymphoma. Primary pulmonary Hodgkin lymphoma is a rare and atypical form of Hodgkin lymphoma; thus is associated with delayed diagnosis which does not seem to affect prognosis. It should be suspected in a child with non-resolving pneumonia and pulmonary parenchymal infiltrates with cavitations. PMID:21147653

2010-01-01

398

Is Chinese Software Engineering Professionalizing or Not?: Specialization of Knowledge, Subjective Identification and Professionalization  

ERIC Educational Resources Information Center

Purpose: This paper aims to discuss the challenge for the classical idea of professionalism in understanding the Chinese software engineering industry after giving a close insight into the development of this industry as well as individual engineers with a psycho-societal perspective. Design/methodology/approach: The study starts with the general…

Yang, Yan

2012-01-01

399

The Chinese University of Hong Kong  

E-print Network

Chinese Culture and Society Fundamentals in Chinese Medicine Government and Politics of China BuddhismThe Chinese University of Hong Kong International Summer School International Summer School 20102010 Founded in 1963, The Chinese University of Hong Kong (CUHK) is a forward looking comprehensive

Takada, Shoji

400

Biotech's Chinese connection  

SciTech Connect

Hong Kong last month opened the Hong Kong Institute of Biotechnology (HKIB), a nonprofit R and D center. By combining Chinese expertise in medicinal compounds and cell culturing with Western technical and marketing skills, the institute hopes to develop products that could be licensed to Hong Kong or Western films. The institute is also developing experimental cell lines and making genetically engineered versions of promising compounds, taking advantage of the cell-culturing and cloning skills that are highly developed on the mainland. The Shanghai contingent is already involved in one of the institute's projects, an effort to transfer human genes into mouse fibroblasts to create cell lines for research on the molecular mechanisms of learning and memory. Other Chinese researchers are taking part in HKIB's joint venture with Syntex, which was signed last April. The mainland researchers extract candidate medicinal compounds from plants and microorganisms. In Hong Kong, the compounds are tested for their effects on neurotransmitter receptors, while Syntex scientists in Palo Alto study how the same compounds affect enzyme activity and whole cells.

Hodgson, G.

1992-03-27

401

Chinese Armillary Spheres  

NASA Astrophysics Data System (ADS)

The armillary sphere was perhaps the most important type of astronomical instrument in ancient China. It was first invented by Luoxia Hong in the first century BC. After Han times, the structure of the armillary sphere became increasingly sophisticated by including more and more rings representing various celestial movements as recognized by the Chinese astronomers. By the eighth century, the Chinese armillary sphere consisted of three concentric sets of rings revolving on the south-north polar axis. The relative position of the rings could be adjusted to reflect the precession of the equinoxes and the regression of the Moon's nodes along the ecliptic. To counterbalance the defect caused by too many rings, Guo Shoujing from the late thirteenth century constructed the Simplified Instruments which reorganized the rings of the armillary sphere into separate instruments for measuring equatorial coordinates and horizontal coordinates. The armillary sphere was still preserved because it was a good illustration of celestial movements. A fifteenth-century replica of Guo Shoujing's armillary sphere still exists today.

Sun, Xiaochun

402

Childhood Hodgkin's lymphoma, non-Hodgkin's lymphoma and factors related to the immune system: the Escale Study (SFCE).  

PubMed

The study investigated the role of factors considered related to the early stimulation of the immune system in the aetiology of childhood lymphoma. The national registry-based case-control study, Escale, was carried out in France over the period 2003-2004. Population controls were frequency matched with the cases on age and gender. Data were obtained from structured telephone questionnaires administered to mothers. Odds ratios (ORs) were estimated using unconditional regression models adjusted for potential confounders. Data from 128 cases of Hodgkin's lymphoma (HL) aged 5-14 years, 164 cases of non-Hodgkin's lymphoma (NHL) aged 2-14 years and 1,312 controls were analyzed. Negative associations were observed between HL and day care attendance [OR = 0.5 (0.2-1.2)] and between HL and repeated early common infections among non-breastfed children [OR = 0.3 (.2-0.7), p = 0.003] [OR for breastfed children: 1.0 (.5-2.1)], but not for the other factors investigated. Negative associations were observed between NHL and birth order 3 or more [OR = 0.7 (0.4-1.1)], prolonged breastfeeding [OR = 0.5 (0.3-1.0)], regular contact with farm animals [OR = 0.5 (0.3-1.0)], frequent farm visits in early life [OR = 0.6 (0.4-1.1)] and history of asthma [OR = 0.6 (0.3-1.1)]. In conclusion, the results partly support the hypothesis that an abnormal maturation of the immune system may play a role in childhood HL or NHL, and call for further investigations. PMID:21170962

Rudant, Jérémie; Orsi, Laurent; Monnereau, Alain; Patte, Catherine; Pacquement, Hélène; Landman-Parker, Judith; Bergeron, Christophe; Robert, Alain; Michel, Gérard; Lambilliotte, Anne; Aladjidi, Nathalie; Gandemer, Virginie; Lutz, Patrick; Margueritte, Geneviève; Plantaz, Dominique; Méchinaud, Françoise; Hémon, Denis; Clavel, Jacqueline

2011-11-01

403

Paternal origins of Chinese cattle.  

PubMed

To determine the genetic diversity and paternal origin of Chinese cattle, 302 males from 16 Chinese native cattle breeds as well as 30 Holstein males and four Burma males as controls were analysed using four Y-SNPs and two Y-STRs. In Chinese bulls, the taurine Y1 and Y2 haplogroups and indicine Y3 haplogroup were detected in seven, 172 and 123 individuals respectively, and these frequencies varied among the Chinese cattle breeds examined. Y2 dominates in northern China (91.4%), and Y3 dominates in southern China (90.8%). Central China is an admixture zone, although Y2 predominates overall (72.0%). The geographical distributions of the Y2 and Y3 haplogroup frequencies revealed a pattern of male indicine introgression from south to north China. The three Y haplogroups were further classified into one Y1 haplotype, five Y2 haplotypes and one Y3 haplotype in Chinese native bulls. Due to the interplay between taurine and indicine types, Chinese cattle represent an extensive reservoir of genetic diversity. The Y haplotype distribution of Chinese cattle exhibited a clear geographical structure, which is consistent with mtDNA, historical and geographical information. PMID:23347145

Li, R; Zhang, X M; Campana, M G; Huang, J P; Chang, Z H; Qi, X B; Shi, H; Su, B; Zhang, R F; Lan, X Y; Chen, H; Lei, C Z

2013-08-01

404

Health Information in Chinese - Simplified (????): MedlinePlus  

MedlinePLUS

... PDF Health Information Translations Back Injuries Back Care - English ???? - ???? (Chinese - Simplified) PDF Chinese Community Health Resource Center Exercises for Your Back ???? - ???? (Chinese - Simplified) PDF ...

405

Classical New England  

NSDL National Science Digital Library

Classical New England is a public service provided by WGBH in Boston with affiliate stations in Nantucket and Providence, Rhode Island. The cornucopia of music here can be explored via the Topics section on the right-hand side of the page. Here visitors can look through programs like "The Bach Hour" and "Classical Music With Cathy Fuller." Not surprisingly, there's an entire section dedicated to Tanglewood, which is the summer home of the Boston Symphony Orchestra (BSO) in western Massachusetts. One notable feature here is the last interview with celebrated music director and conductor Erich Leinsdorf, in which he ruminates on his time working with the BSO. Additionally, users can look over the Most Popular list to learn about what other classical music fans are enjoying. Finally, the site also includes videos of various performances from around New England and beyond.

2012-09-07

406

WMCI Community Courses (Beginning Chinese I, II, III; Business Chinese;  

E-print Network

and Community Courses at W&MWashington DC Office Summer Session Chinese Bridge Summer Camp July 2013 Summer Camp Confucius Institute Spring and Summer 2013 Events and Activities www.wm.edu/confuciusinstitute (757) 221

Lewis, Robert Michael

407

Classic Organic Reactions  

NSDL National Science Digital Library

Despite the fact that the Classic Organic Reactions Page was designed for commercial purposes, to demonstrate the capabilities of ChemPen chemical structure drawing software for Windows, the page offers a useful resource for chemistry students and professionals. The creator of this page, and author and proprietor of ChemPen, Dr. Hilton Evans, has cited the literature for each reaction. The site contains drawings for over 300 alphabetically listed classic organic reactions. The list begins with the Acetoacetic Ester Condensation and ends with the Zinke-Suhl Reaction.

408

Study on Translating Chinese into Chinese Sign Language  

Microsoft Academic Search

Sign language is a visual-gestural language mainly used by hearing-impaired people to communicate with each other. Gesture\\u000a and facial expression are important grammar parts of sign language. In this paper, a text-based transformation method of Chinese-Chinese\\u000a sign language machine translation is proposed. Gesture and facial expression models are created. And a practical system is\\u000a implemented. The input of the system

Xu Lin; Wen Gao

2000-01-01

409

The Chinese healthcare challenge  

PubMed Central

Investments in the extension of health insurance coverage, the strengthening of public health services, as well as primary care and better hospitals, highlights the emerging role of healthcare as part of China’s new growth regime, based on an expansion of services, and redistributive policies. Such investments, apart from their central role in terms of relief for low-income people, serve to rebalance the Chinese economy away from export-led growth toward the domestic market, particularly in megacity-regions as Shanghai and the Pearl River Delta, which confront the challenge of integrating migrant workers. Based on the paper by Gusmano and colleagues, one would expect improvements in population health for permanent residents of China’s cities. The challenge ahead, however, is how to address the growth of inequalities in income, wealth and the social wage. PMID:25774379

Fabre, Guilhem

2015-01-01

410

Chinese Historical Society  

NSDL National Science Digital Library

Archaeological digs can tell us much about ancient civilizations, but what about more recent periods of human habitation? This fine collection from the USC Digital Library presents over 1,100 images of artifacts excavated from two sites in Southern California. The Chinatown section features 1,040 color images of artifacts from the original Los Angeles Chinatown. These items were recovered during the construction of the Metro Rail Red Line by the Los Angeles County Metropolitan Transportation Authority. The online collection includes photos of wine bowls, ink stone boxes, and other fragments of items from daily household life. The second segment includes items excavated in 1992 from an old adobe structure in Santa Barbara that housed a Chinese laundry from the mid 1880s to 1905. The collection can be searched via keyword, and it is quite a resource for historians, archaeologists, and others.

2012-02-03

411

Chinese Military Power  

NSDL National Science Digital Library

This new resource from the Commonwealth Institute's Project on Defense Alternatives (PDA) (reviewed in the January 12, 1999 Scout Report for Social Sciences) offers a gateway to "online analysis and research tools essential to understanding China's military policy, capabilities, and potential." The full-text offerings are accessed through links to a variety of English-language sources, and are grouped by topic, such as Commentary, Military Analyses, Political and Economic Conditions, Regional Context, and US Policy Toward China, among others. In addition, online resources on several special topics (China and the RMA, Arms Trade and Proliferation, Taiwan Confrontation, Cox Report and Aftermath, and China Arsenal) are also provided. Other resources include a bibliography, links to selected research sites, and contact information for a number of specialists in the field. If the site remains regularly updated as promised, it should become a useful current awareness tool for researchers and students studying Chinese military policy and US-China military relations.

412

Mathematics of the Chinese Calendar  

NSDL National Science Digital Library

A mathematics professor from UC Berkeley, currently on sabbatical and at the National University of Singapore, has posted this information about the Mathematics of the Chinese Calendar. Professor Helmer Aslaksen gives some background on why he has developed this webpage, noting that "Chinese New Year is the main holiday of the year for more than one quarter of the world's population; very few people, however, know how to compute its date." Having little success in finding any information on the rules of the Chinese Calendar, he decided to work it out himself. Posted here are some of his papers on the Mathematics of the Chinese Calendar, along with an overall explanation of his method of calculation and several astronomical Java Applets and Animations to help explain the motion of the Earth and the Sun. His website on Heavenly Mathematics provides further ideas on ways to teach astronomy in a cultural context.

413

Chinese Constellations and Star Maps  

NASA Astrophysics Data System (ADS)

Star observations can be traced back to as early as the twenty-third century BC in ancient China. By the fifth century BC, the Chinese had named the 28 asterisms that formed the basic reference points for the Chinese equatorial coordinate system. By the first century BC, the Chinese had developed a unique system of constellations that reflected Chinese cosmological ideas with the central theme of the correlation between Heaven and Man. Star charts have been discovered on tomb ceilings dating back to Han times. But most of them are illustrative in their presentation of stars. The Dunhuang star maps from the ninth century, the star maps in the Xin yixiang fa yao of the eleventh century, and the Suzhou Astronomical Planisphere of the thirteenth century are examples of precise star maps from ancient China.

Sun, Xiaochun

414

CLASSICAL, MEDIEVAL RENAISSANCE STUDIES  

E-print Network

in the 8th century BCE to 17th-century Italy and the England of Shakespeare, Bacon and Hobbes. Students as the Western Tradition. Drawing on the resources of twelve departments in Arts & Science and St Thomas More centuries AD Replica from the Museum of Antiquities, University of Saskatchewan 1 #12;CLASSICAL, MEDIEVAL

Peak, Derek

415

Classics in What Sense?  

ERIC Educational Resources Information Center

They seem the perfect bookends for the social psychologist's collection of "classics" of the field. Two volumes, nearly identical in shape and weight and exactly a century old in 2008--each professing to usher "social psychology" into the world as they both place the hybrid expression square in their titles but then proceed to stake out the field…

Camic, Charles

2008-01-01

416

Mecanica Clasica (Classical Mechanics)  

E-print Network

First Internet undergraduate course on Classical Mechanics in Spanish (Castellano). This is about 80% of the material I covered during the January-June 1999 semester at IFUG in the Mexican city of Leon. English and Romanian versions are in (slow) progress and hopefully will be arXived. For a similar course on Quantum Mechanics, see physics/9808031

Rosu, H C

1999-01-01

417

The Classical Cake Problem  

ERIC Educational Resources Information Center

Discussed are techniques of presentation and solution of the Classical Cake Problem. A frosted cake with a square base is to be cut into n pieces with the volume of cake and frosting the same for each piece. Needed are minimal geometric concepts and the formula for the volume of a prism. (JP)

Nelson, Norman N.; Fisch, Forest N.

1973-01-01

418

Classicism and Romanticism.  

ERIC Educational Resources Information Center

Describes one teacher's methods for introducing to secondary English students the concepts of Classicism and Romanticism in relation to pictures of gardens, architecture, music, and literary works. Outlines how the unit leads to a writing assignment based on collected responses over time. (HB)

Huddleston, Gregory H.

1993-01-01

419

Classical Curriculum Design  

ERIC Educational Resources Information Center

The article identifies some key findings in pedagogical research over recent decades, placing them within a framework of logical curriculum development and current practice in quality assurance and enhancement. Throughout, the ideas and comments are related to the practice of teaching classics in university. (Contains 1 figure and 3 notes.)

George, Judith W.

2009-01-01

420

Classical Dark Matter  

E-print Network

Classical particle-like solutions of field equations such as general relativity, could account for dark matter. Such particles would not interact quantum mechanically and would have negligible interactions apart from gravitation. As a relic from the big bang, they would be a candidate for cold dark matter consistent with observations.

Mark J Hadley

2007-01-17

421

Introducing Classics to Undergraduates  

ERIC Educational Resources Information Center

University students in India generally dislike reading English classics, but some students well prepared in advance enjoyed Dickens'"Tale of Two Cities." They first read an illustrated comic book version, then read a dramatized version while listening to a recording, and then read an abridged version before reading the original. (CFM)

Kumar, Sarat

1978-01-01

422

Teaching Tomorrow's Classics.  

ERIC Educational Resources Information Center

Describes young adult novels that may prove to be classics of the genre. Discusses "The "Chocolate War" by Robert Cormier, "The Outsiders" by S. E. Hinton, "The Witch of Blackbird Pond" by Elizabeth George Speare, and "On Fortune's Wheel" by Cynthia Voight. (HB)

Tighe, Mary Ann; Avinger, Charles

1994-01-01

423

Dismantling MIFARE Classic  

Microsoft Academic Search

The mifare Classic is a contactless smart card that is used extensively in access control for office buildings, payment systems for public transport, and other applications. We reverse engineered the se- curity mechanisms of this chip: the authentication protocol, the symmet- ric cipher, and the initialization mechanism. We describe several security vulnerabilities in these mechanisms and exploit these vulnerabilities with

Flavio D. Garcia; Gerhard De Koning Gans; Ruben Muijrers; Peter Van Rossum; Roel Verdult; Ronny Wichers Schreur; Bart Jacobs

2008-01-01

424

Classical Mechanics Simulations  

Microsoft Academic Search

Classical Mechanics Simulations is one of a series of nine comprehensive books that have been produced by the Consortium for Upper-Level Physics software (CUPS), which is funded by the United States National Science Foundation. They are intended to be used in conjunction with physics undergraduate courses. Each volume has one or more diskettes containing a number of versatile computer programs.

Cyril Isenberg

1996-01-01

425

Classical Mythology. Fourth Edition.  

ERIC Educational Resources Information Center

Designed for students with little or no background in classical literature, this book introduces the Greek and Roman myths of creation, myths of the gods, Greek sagas and local legends, and presents contemporary theories about the myths. Drawing on Homer, Hesiod, Pindar, Vergil, and others, the book provides many translations and paraphrases of…

Morford, Mark P. O.; Lenardon, Robert J.

426

Careers in the Classics  

ERIC Educational Resources Information Center

America's few Black classics professors have overcome contempt and criticism to contribute a unique perspective to the study of the ancient world. Dr. Patrice Rankine, an associate professor from Purdue University, has grown used to the irony. As one of the few Black classicists teaching at an American university, he has drawn plenty of skepticism…

Lum, Lydia

2005-01-01

427

Quantum particles from classical statistics  

E-print Network

Quantum particles and classical particles are described in a common setting of classical statistical physics. The property of a particle being "classical" or "quantum" ceases to be a basic conceptual difference. The dynamics differs, however, between quantum and classical particles. We describe position, motion and correlations of a quantum particle in terms of observables in a classical statistical ensemble. On the other side, we also construct explicitly the quantum formalism with wave function and Hamiltonian for classical particles. For a suitable time evolution of the classical probabilities and a suitable choice of observables all features of a quantum particle in a potential can be derived from classical statistics, including interference and tunneling. Besides conceptual advances, the treatment of classical and quantum particles in a common formalism could lead to interesting cross-fertilization between classical statistics and quantum physics.

C. Wetterich

2010-02-11

428

Chinese journals: a guide for epidemiologists  

PubMed Central

Chinese journals in epidemiology, preventive medicine and public health contain much that is of potential international interest. However, few non-Chinese speakers are acquainted with this literature. This article therefore provides an overview of the contemporary scene in Chinese biomedical journal publication, Chinese bibliographic databases and Chinese journals in epidemiology, preventive medicine and public health. The challenge of switching to English as the medium of publication, the development of publishing bibliometric data from Chinese databases, the prospect of an Open Access publication model in China, the issue of language bias in literature reviews and the quality of Chinese journals are discussed. Epidemiologists are encouraged to search the Chinese bibliographic databases for Chinese journal articles. PMID:18826604

Fung, Isaac CH

2008-01-01

429

Classical and quantal ternary algebras  

NASA Astrophysics Data System (ADS)

We consider several ternary algebras relevant to physics. We compare and contrast the quantal versions of the algebras, as realized through associative products of operators, with their classical counterparts, as realized through classical Nambu brackets. In some cases involving infinite algebras, we show the classical limit may be obtained by a contraction of the quantal algebra, and then explicitly realized through classical brackets. We illustrate this classical-contraction method by the Virasoro-Witt example.

Curtright, Thomas; Fairlie, David; Jin, Xiang; Mezincescu, Luca; Zachos, Cosmas

2009-05-01

430

Structure of classical affine and classical affine fractional W -algebras  

NASA Astrophysics Data System (ADS)

We introduce a classical BRST complex (See Definition 3.2.) and show that one can construct a classical affine W -algebra via the complex. This definition clarifies that classical affine W -algebras can be considered as quasi-classical limits of quantum affine W -algebras. We also give a definition of a classical affine fractional W -algebra as a Poisson vertex algebra. As in the classical affine case, a classical affine fractional W -algebra has two compatible ?-brackets and is isomorphic to an algebra of differential polynomials as a differential algebra. When a classical affine fractional W -algebra is associated to a minimal nilpotent, we describe explicit forms of free generators and compute ?-brackets between them. Provided some assumptions on a classical affine fractional W -algebra, we find an infinite sequence of integrable systems related to the algebra, using the generalized Drinfel'd and Sokolov reduction.

Suh, Uhi Rinn

2015-01-01

431

A Self-Organizing State-Space-Model Approach for Parameter Estimation in Hodgkin-Huxley-Type Models of Single Neurons  

E-print Network

1 A Self-Organizing State-Space-Model Approach for Parameter Estimation in Hodgkin, which was applied on a number of Hodgkin-Huxley- type models using simulated or actual Adaptation Evolution Strategy in order to estimate a large number of parameters in a number of Hodgkin

Feng, Jianfeng

432

Table 3.9. Risk of Non-Hodgkin's Lymphoma Among Vietnam Veterans, by Numbe!' of Years Since Start of First Tour in Vietnam  

E-print Network

Table 3.9. Risk of Non-Hodgkin's Lymphoma Among Vietnam Veterans, by Numbe!' of Years Since Start of First Tour in Vietnam Non-Hodgkin's Controls Lymphoma Cases Odds ratloC (N = 133) (N =99) Number catego rI (unknowns excluded) C Odds ratios estimate the relative risk of non-Hodgkin's lymphoma

433

HEDS Discussion Paper: Cost-effectiveness of G-CSFs for febrile neutropenia prophylaxis in non-Hodgkin's lymphoma: Whyte et al  

E-print Network

HEDS Discussion Paper: Cost-effectiveness of G-CSFs for febrile neutropenia prophylaxis in non-Hodgkin prophylaxis in non-Hodgkin's lymphoma: Whyte et al - 2 - #12;HEDS Discussion Paper: Cost-effectiveness of G-CSFs for febrile neutropenia prophylaxis in non-Hodgkin's lymphoma: Whyte et al - 3 - Cost

Oakley, Jeremy

434

Spontaneous spiking in an autaptic Hodgkin-Huxley setup  

NASA Astrophysics Data System (ADS)

The effect of intrinsic channel noise is investigated for the dynamic response of a neuronal cell with a delayed feedback loop. The loop is based on the so-called autapse phenomenon in which dendrites establish connections not only to neighboring cells but also to its own axon. The biophysical modeling is achieved in terms of a stochastic Hodgkin-Huxley model containing such a built in delayed feedback. The fluctuations stem from intrinsic channel noise, being caused by the stochastic nature of the gating dynamics of ion channels. The influence of the delayed stimulus is systematically analyzed with respect to the coupling parameter and the delay time in terms of the interspike interval histograms and the average interspike interval. The delayed feedback manifests itself in the occurrence of bursting and a rich multimodal interspike interval distribution, exhibiting a delay-induced reduction in the spontaneous spiking activity at characteristic frequencies. Moreover, a specific frequency-locking mechanism is detected for the mean interspike interval.

Li, Yunyun; Schmid, Gerhard; Hänggi, Peter; Schimansky-Geier, Lutz

2010-12-01

435

Definitive irradiation for localized non-Hodgkin's lymphoma of breast.  

PubMed

A diagnosis of primary non-Hodgkin's lymphoma (NHL) confined to the breast or breast and ipsilateral lymph nodes was biopsy proven in 19 patients who presented to our institution between 1970 and 1984. Four patients were treated with a modified radical mastectomy, and one with chemotherapy only. The remaining 14 patients comprise the basis of this study. All patients were clinically staged. There were 12 patients with 1A-E disease and two with IIA-E disease. All patients were treated with breast radiation. The axillary nodes were included in seven of the patients and two, in addition, received "mantle" irradiation. The majority of the patients received between 3500-4400 cGy, but four received lower doses. One patient, with Stage IIA-E disease, received 6 months of systemic chemotherapy, followed by 3500 cGy to the breast and axilla. Three of the 14 patients relapsed within the treated area, with a local control rate of 78%. One was salvaged with a mastectomy and remains alive and well 15 years after diagnosis. Seven of the 14 patients relapsed distantly, including two with local failures, but only three have died of disease. An additional two patients have died of other causes without evidence of disease, for a survival of 66% at 48 months (Kaplan-Meier Calculations). PMID:2777674

DeBlasio, D; McCormick, B; Straus, D; Smith, M; Brustein, S; Nisce, L; Fuks, Z

1989-10-01

436

Health Practice in Long-Term Survivors of Hodgkin's Lymphoma  

SciTech Connect

Purpose: To compare the health practice of Hodgkin's lymphoma (HL) survivors and their siblings, and to assess the impact of socioeconomic status and disease history on health practice of HL survivors. Methods and Materials: We conducted a questionnaire study on long-term HL survivors and their siblings on health care utilization, health habits, and screening behavior. Results: A total of 511 HL survivors (response rate of 50%, including survivors lost to contact) and 224 siblings (response rate, 58%) participated. Median time from HL diagnosis was 15 years. Significantly more survivors than siblings had a physical examination in the past year (63% vs. 49%, p = 0.0001). Male survivors were significantly more likely than siblings to perform monthly self-testicular examinations (19% vs. 9%, p = 0.02). Among survivors, higher household income (p = 0.01) independently predicted for having had a physical examination in the past year. Lower educational level (p = 0.0004) and history of relapsed HL (p = 0.03) were independent predictors for smoking, moderate/heavy alcohol use, and/or physical inactivity. Conclusions: Compared with siblings, long-term HL survivors have a higher level of health care utilization and better screening practice. Survivors from lower socioeconomic background had lower adherence to routine health care and greater report of unhealthy habits. Survivors with history of relapsed HL were also more likely to engage in unhealthy habits.

Ng, Andrea K. [Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA (United States)], E-mail: ang@lroc.harvard.edu; Li Sigui [Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA (United States); Recklitis, Christopher; Diller, Lisa R. [Department of Pediatric Oncology, Dana-Farber Cancer Institute, Boston, MA (United States); Neuberg, Donna [Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, MA (United States); Silver, Barbara; Mauch, Peter M. [Department of Radiation Oncology, Brigham and Women's Hospital, Boston, MA (United States)

2008-06-01

437

Energy and information in Hodgkin-Huxley neurons  

E-print Network

The generation of spikes by neurons is energetically a costly process and the evaluation of the metabolic energy required to maintain the signalling activity of neurons a challenge of practical interest. Neuron models are frequently used to represent the dynamics of real neurons but hardly ever to evaluate the electrochemical energy required to maintain that dynamics. This paper discusses the interpretation of a Hodgkin-Huxley circuit as an energy model for real biological neurons and uses it to evaluate the consumption of metabolic energy in the transmission of information between neurons coupled by electrical synapses, i.e. gap junctions. We show that for a single postsynaptic neuron maximum energy efficiency, measured in bits of mutual information per ATP molecule consumed, requires maximum energy consumption. On the contrary, for groups of parallel postsynaptic neurons we determine values of the synaptic conductance at which the energy efficiency of the transmission presents clear maxima at relatively very low values of metabolic energy consumption. Contrary to what it could be expected best performance occurs at low energy cost.

A. Moujahid; A. d'Anjou; F. J. Torrealdea

2012-05-02

438

Early-stage Hodgkin's disease: current approaches to treatment.  

PubMed Central

Most patients with early-stage Hodgkin's disease can now be cured by one of several therapeutic approaches. This review highlights the developments in the diagnosis and treatment of the disease that have led to long-term survival rates greater than 90%. Past and present radio-therapy (RT) planning and treatment practices are discussed in the context of both clinical and pathological staging. The role of initial bimodal therapy (RT and chemotherapy [CT]) and the use of CT in patients who suffer relapse after initial treatment with RT alone are reviewed. On the basis of prognostic factors, subgroups of patients for whom bimodal therapy is recommended, including those with a bulky mediastinal mass, have now been identified. Although treatment is highly successful, debilitating consequences of RT and CT, such as infertility, infection and second malignant diseases, remain. Newer treatment regimens may reduce morbidity and have similar or better long-term results with respect to survival and quality of life. PMID:3893668

Rusthoven, J J; MacKenzie, R

1985-01-01

439

Longitudinal studies of blood lymphocyte capacity in Hodgkin's disease  

SciTech Connect

Blood lymphocyte functional capacity and serum immunoglobulins were studied in 40 patients with Hodgkin's disease (HD) admitted to Radiumhemmet, Stockholm, before treatment and in complete remission 2-56 months following termination of radiotherapy (total nodal irradiation (TNI); n . 29) or chemotherapy (MOPP; n . 11). Lymphocyte studies included determination of total lymphocyte and T-cell counts and evaluation of spontaneous DNA synthesis during the first day of culture and mitogen-(concanavalin A, pokeweed mitogen) and antigen (purified protein derivative, PPD)-induced activation on the third day. Blood lymphocyte and T-cell counts decreased dramatically following TNI. A slow restitution was seen, but pretreatment levels were not reached even four years following therapy. The responses to ConA and PPD but not PWM were significantly reduced shortly after TNI. The mitogen response did not increase with time as did the PPD response. Lymphocyte counts and lymphocyte stimulation, which were severely depressed before treatment of patients in the chemotherapy group, remained unchanged 2-36 months after termination of therapy. A significant reduction of IgM levels was observed regardless of the mode of treatment. Splenectomy prevented the profound reduction of blood lymphocyte and T-cell counts following therapy but did not influence the other immunologic variables under study.

Bjoerkholm, M.; Wedelin, C.; Holm, G.; Johansson, B.; Mellstedt, H.

1981-11-01

440

Testicular non-Hodgkin's lymphoma presenting in a young adult.  

PubMed

We report a case of a 27-year-old man who presented with a slowly growing left testicular swelling associated with mild pain over a period of 3?months. He was evaluated by his family physician with scrotal ultrasound and testicular tumour markers. He was diagnosed and treated as epididymo-orchitis and managed with antibiotics. When he later presented to us, he had an enlarged left testis with normal spermatic cord. Scrotal Doppler evaluation showed a globally enlarged left testis and epididymis with increased vascularity in the left testis, with the right testis being normal. Testicular tumour markers were normal. Fine-needle aspiration cytology of the left testis was suggestive of lymphoma. Exploration through an inguinal approach was carried out and a Chevassu manoeuvre with frozen section study was performed, which was reported as non-Hodgkin's lymphoma. Left radical orchidectomy was performed. Histopathology reported diffuse large B-cell lymphoma, of a germinal centre type. Contrast CT of the abdomen, chest and brain were normal. Sperm cryopreservation was carried out. The patient was started on chemotherapy with cyclophosphamide, hydroxydaunorubicin, oncovin, prednisone (CHOP) regime. PMID:25795748

Ratkal, Vishal; Chawla, Arun; Mishra, Dilip Kumar; Monappa, Vidya

2015-01-01

441

Thyroid dysfunction after radiotherapy in children with Hodgkin's disease  

SciTech Connect

Thyroid function was measured in 119 children, 16 years of age or less, after radiotherapy (XRT) for Hodgkin's disease. Thyroid abnormalities developed in 4 of 24 children (17%) who received 2600 rad or less, and in 74 of 95 children (78%) who received greater than 2600 rad to the cervical area, including the thyroid. The abnormality in all but three (one with hyperthyroidism and two with thyroid nodules) included the development of elevated levels of thyroid stimulating hormone (TSH). Age, sex, and administration of chemotherapy were not significant factors in the development of thyroid dysfunction. All children had lymphangiograms (LAG) and no time relationship was noted between thyroid dysfunction and LAG-XRT interval. The mean interval from radiotherapy to documented thyroid dysfunction was 18 months in the low-dose group and 31 months in the high-dose group, with most patients becoming abnormal within 3 to 5 years. Of interest was a spontaneous return of TSH to within normal limits in 20 children and substantial improvement in another 7. This study confirms the occurrence of dose-related occult hypothyroidism in children following external irradiation of the neck.

Constine, L.S.; Donaldson, S.S.; McDougall, I.R.; Cox, R.S.; Link, M.P.; Kaplan, H.S.

1984-02-15

442

Pharmacogenetic analysis in the treatment of Hodgkin lymphoma.  

PubMed

About 15-20% of patients with Hodgkin lymphoma (HL) treated with doxorubicin, bleomycin, vinblastine and dacarbazine (ABVD) chemotherapy ± radiotherapy still die following relapse or progressive disease. The outcome might be influenced by gene polymorphisms influencing chemotherapy metabolism. We studied 126 patients with HL treated with the ABVD regimen. We analyzed glutathione S-transferases (GSTT1, GSTM1 and GSTP1), cytochromes P450 (CYP3A4 and CYP2D6), UGT1A1 and BLMH gene polymorphisms and their association with clinical and outcome variables. Patients with a GSTM1 genotype associated with extensive or ultrahigh activity had a probability of 93.8% to achieve a complete response, while the remainder of the patients had a probability of 82.3% (p = 0.04). This variable maintained its statistical significance in multivariate analysis (hazard ratio 3.7, 95% confidence interval 1-13, p = 0.05). Patients with an extensive or ultrahigh GSTM1 genotype had better prognostic factors than those with poor or intermediate genotypes (hemoglobin level, p = 0.003; serum albumin, p = 0.05; and International Prognostic Score, p = 0.038). Thus, in the treatment of HL, clinical determinants might be more relevant than the pharmacogenetic parameters analyzed to date. PMID:23323945

Altés, Albert; Paré, Laia; Esquirol, Albert; Xicoy, Blanca; Rámila, Elena; Vicente, Laura; López, Rosario; Orriols, Jaume; Vall-llovera, Ferran; Sánchez-González, Blanca; del Río, Elisabeth; Sureda, Anna; Páez, David; Baiget, Montserrat

2013-08-01

443

Angiogenesis and antiangiogenic therapy in non-Hodgkin's lymphoma  

PubMed Central

Angiogenesis, the growth of new blood vessels, requires dynamic expansion, assembly and stabilization of vascular endothelial cells in response to proangiogenic stimuli. Antiangiogenic strategies have become an important therapeutic modality for solid tumors. While many aspects of postnatal pathological angiogenesis have been extensively studied in the context of nonhematopoietic neoplasms, the precise role of these processes in lymphoma pathogenesis is under active investigation. Lymphoma growth and progression is potentiated by at least two distinct angiogenic mechanisms: autocrine stimulation of tumor cells via expression of vascular endothelial growth factor (VEGF) and VEGF receptors by lymphoma cells, as well as paracrine influences of proangiogenic tumor microenvironment on both local neovascular transformation and recruitment of circulating bone marrow-derived progenitors. Lymphoma-associated infiltrating host cells including hematopoietic monocytes, T cells and mesenchymal pericytes have increasingly been associated with the pathogenesis and prognosis of lymphoma, in part providing perivascular guidance and support to neoangiogenesis. Collectively, these distinct angiogenic mechanisms appear to be important therapeutic targets in selected non-Hodgkin's lymphoma (NHL) subtypes. Understanding these pathways has led to the introduction of antiangiogenic treatment strategies into the clinic where they are currently under assessment in several ongoing studies of NHL patients. PMID:19088170

Ruan, J.; Hajjar, K.; Rafii, S.; Leonard, J. P.

2009-01-01

444

The ISI distribution of the stochastic Hodgkin-Huxley neuron  

PubMed Central

The simulation of ion-channel noise has an important role in computational neuroscience. In recent years several approximate methods of carrying out this simulation have been published, based on stochastic differential equations, and all giving slightly different results. The obvious, and essential, question is: which method is the most accurate and which is most computationally efficient? Here we make a contribution to the answer. We compare interspike interval histograms from simulated data using four different approximate stochastic differential equation (SDE) models of the stochastic Hodgkin-Huxley neuron, as well as the exact Markov chain model simulated by the Gillespie algorithm. One of the recent SDE models is the same as the Kurtz approximation first published in 1978. All the models considered give similar ISI histograms over a wide range of deterministic and stochastic input. Three features of these histograms are an initial peak, followed by one or more bumps, and then an exponential tail. We explore how these features depend on deterministic input and on level of channel noise, and explain the results using the stochastic dynamics of the model. We conclude with a rough ranking of the four SDE models with respect to the similarity of their ISI histograms to the histogram of the exact Markov chain model. PMID:25339894

Rowat, Peter F.; Greenwood, Priscilla E.

2014-01-01

445

Epstein-Barr virus and Hodgkin's disease. A correlative in situ hybridization and polymerase chain reaction study.  

PubMed Central

The authors studied typical Hodgkin's disease along with the nodular, lymphocyte predominance subtype by both the polymerase chain reaction (PCR) and in situ hybridization for evidence of the Epstein-Barr virus (EBV). By PCR, EBV DNA was detected in 12/23 cases of typical Hodgkin's disease and 2/13 cases of the nodular, lymphocyte predominance subtype. EBV RNA was detected by in situ hybridization studies within Reed-Sternberg cells and variants in 11/23 cases of typical Hodgkin's disease and 0/13 cases of nodular, lymphocyte predominance Hodgkin's disease. Other cells positive for EBV, identified as both B and T cells in double-labeling immunohistochemical/in situ hybridization studies, were found in 20/23 cases of typical Hodgkin's disease, 9/13 cases of nodular, lymphocyte predominance Hodgkin's disease, 4/6 cases of progressive transformation of germinal centers, and 7/10 normal lymphoid tissues. It is concluded that EBV is significantly associated with Reed-Sternberg cells in approximately one-half cases of typical Hodgkin's disease but not in the nodular, lymphocyte predominance subtype. EBV-infected B and T cells are also present in a majority of cases of Hodgkin's disease as well as in reactive conditions. Images Figure 1 Figure 2 PMID:1661073

Weiss, L. M.; Chen, Y. Y.; Liu, X. F.; Shibata, D.

1991-01-01

446

Cancer du sein secondaire après traitement pour maladie de Hodgkin. À propos de sept cas  

Microsoft Academic Search

ObjectiveTherapeutic results of Hodgkin disease (HD) have improved by the use of combined radio-chemotherapy. However, this association can increase the risk of on-term effects including secondary cancers. In a retrospective study, we collected secondary breast cancer (BC) in patients previously treated with chemoradiotherapy for Hodgkin disease at Salah-Azaïz institute of Tunis.

J. Ben Hassouna; M. Slimène; H. Boussen; H. Bouzaiene; F. Khomsi; R. Chargui; L. Kochbati; M. H. Mtaallah; A. Gamoudi; F. Benna; M. Hechiche; K. Rahal

2007-01-01

447

Localizzazione testicolare di linfoma non-Hodgkin extranodale multifocale. Report su due casi, revisione della letteratura e considerazioni cliniche  

Microsoft Academic Search

The aim of our study is to describe two cases of testicular localization of non- Hodgkin Lymphoma associated with the involvement of other extranodal organs, and to in- vestigate the possible causes of this association according to the evidences found in liter- ature. Non-Hodgkin Lymphoma is extranodal in 25% of cases. Most of the times the organs involved are stomach,

P. CHIERIGO; L. NICOLARDI; M. RAHMATI; M. LAZZAROTTO; D. BROTZA; F. BASSAN; N. FRANZOLIN

448

Valvular Dysfunction and Carotid, Subclavian, and Coronary Artery Disease in Survivors of Hodgkin Lymphoma Treated With Radiation Therapy  

Microsoft Academic Search

Context The majority of patients with Hodgkin lymphoma are young and highly cur- able. This necessitates concern for prevention, diagnosis, and optimal management of potential treatment-related complications. Objective To identify and quantify the incidence of and factors contributing to long- term cardiac and vascular complications after radiation therapy for Hodgkin lym- phoma. Design and Setting Retrospective study comparing patients treated

Matthew C. Hull; Christopher G. Morris; Carl J. Pepine; Nancy Price Mendenhall

2010-01-01

449

Valvular Dysfunction and Carotid, Subclavian, and Coronary Artery Disease in Survivors of Hodgkin Lymphoma Treated With Radiation Therapy  

Microsoft Academic Search

Context The majority of patients with Hodgkin lymphoma are young and highly cur- able. This necessitates concern for prevention, diagnosis, and optimal management of potential treatment-related complications. Objective To identify and quantify the incidence of and factors contributing to long- term cardiac and vascular complications after radiation therapy for Hodgkin lym- phoma. Design and Setting Retrospective study comparing patients treated

Matthew C. Hull; Christopher G. Morris; Carl J. Pepine; Nancy Price Mendenhall

2003-01-01

450

The classical geometrization electromagnetism  

E-print Network

Following the line of the history, if by one side the electromagnetic theory was consolidated on the 19th century, the emergence of the special and the general relativity theories on the 20th century opened possibilities of further developments, with the search for the unification of the gravitation and the electromagnetism on a single unified theory. Some attempts to the geometrization of the electromagnetism emerged in this context, where these first models resided strictly on a classical basis. Posteriorly, they were followed by more complete and embracing quantum field theories. The present work reconsiders the classical viewpoint, with the purpose of showing that in a first order of approximation the electromagnetism constitutes a geometric structure aside other phenomena as gravitation. Even though being limited, the model is consistent and offers the possibility of an experimental test of validity.

C. A. Duarte

2015-02-11

451

Classical Language Instruction Project  

NSDL National Science Digital Library

Developed by Christian Wildberg at Princeton University, the Classical Language Instruction Project is designed to function as a resource for college undergraduates hoping to gain some insight into the pronunciation and elocution of ancient Greek and Latin. As the rationale for the Project states on the site: "There may be considerable debate among scholars about the most 'authentic' way to pronounce Greek or Latin; yet it is certain that the texts from the ancient world reflect a vivid and complex spoken language, not a lifeless code." With that in mind, the site features different classical scholars reading passages by a number of writers, including Homer, Plato, Virgil, Horace, Ovid, and Seneca. As the scholars read, students can follow along, view the passage in English, and pause the recording in order to develop an understanding of the text and its pronunciation. Finally, the site also includes a brief essay on rhythm and meter in Greek and Latin.

452

Classically isospinning Skyrmion solutions  

E-print Network

We investigate how isospin affects the geometrical shape and energy of classical soliton solutions of topological charges $B=1-4,8$ in the Skyrme model. The novel approach in our work is that we study classically isospinning Skyrmions beyond the rigid-body approximation; that is, we explicitly allow the soliton solutions to deform and to break the symmetries of the static configurations. Our fully three-dimensional relaxation calculations reveal that the symmetries of isospinning Skyrme solitons can differ significantly from the ones of the static configurations. In particular, isospinning Skyrmion solutions can break up into lower-charge Skyrmions, can deform into new solution types that do not exist at vanishing angular frequency $\\omega$ or energy degeneracy can be removed. These types of deformations have been largely ignored in previous work on modeling nuclei by quantized Skyrmion solutions.

Richard A. Battye; Mareike Haberichter; Steffen Krusch

2015-01-02

453

Classically isospinning Skyrmion solutions  

NASA Astrophysics Data System (ADS)

We investigate how isospin affects the geometrical shape and energy of classical soliton solutions of topological charges B =1 - 4 ,8 in the Skyrme model. The novel approach in our work is that we study classically isospinning Skyrmions beyond the rigid-body approximation; that is, we explicitly allow the soliton solutions to deform and to break the symmetries of the static configurations. Our fully three-dimensional relaxation calculations reveal that the symmetries of isospinning Skyrme solitons can differ significantly from the ones of the static configurations. In particular, isospinning Skyrmion solutions can break up into lower-charge Skyrmions, can deform into new solution types that do not exist at vanishing angular frequency ? or energy degeneracy can be removed. These types of deformations have been largely ignored in previous work on modeling nuclei by quantized Skyrmion solutions.

Battye, Richard A.; Haberichter, Mareike; Krusch, Steffen

2014-12-01

454

Bidirectional coherent classical communication  

E-print Network

A unitary interaction coupling two parties enables quantum communication in both the forward and backward directions. Each communication capacity can be thought of as a tradeoff between the achievable rates of specific types of forward and backward communication. Our first result shows that for any bipartite unitary gate, coherent classical communication is no more difficult than classical communication -- they have the same achievable rate regions. Previously this result was known only for the unidirectional capacities (i.e., the boundaries of the tradeoff). We then relate the tradeoff curve for two-way coherent communication to the tradeoff for two-way quantum communication and the tradeoff for coherent communiation in one direction and quantum communication in the other.

Aram W. Harrow; Debbie W. Leung

2005-05-12

455

Implementation of contemporary radiation therapy planning concepts for pediatric Hodgkin lymphoma: Guidelines from the International Lymphoma Radiation Oncology Group.  

PubMed

The optimal management of children with Hodgkin lymphoma (HL) should limit the risk of treatment-related toxicity without compromising disease control. Consequently, increasing effort is being directed to retaining the demonstrated efficacy of radiation therapy (RT) in maximizing the cure of HL while reducing the radiation exposure of normal tissues. Historically, guidelines for RT volume definition used in pediatric HL trials have referenced 2-dimensional imaging and bony landmarks to define classical involved field RT. With recognition of the efficacy of chemotherapy, the data on the adverse late effects of radiation, and the evolution of advanced imaging techniques that reveal the location of both tumor and normal tissues, it is necessary that radiation techniques for children and adolescents be refined. The concepts described by the International Commission on Radiation Units provide a common approach for field definition using 3-dimensional computed tomographic--based RT planning and volumetric image guidance. Here we describe the application of these concepts in the planning of RT for pediatric HL. This will be increasingly important as current and upcoming pediatric HL trials will employ these concepts to deliver RT. PMID:25413415

Hodgson, David C; Dieckmann, Karin; Terezakis, Stephanie; Constine, Louis

2015-01-01

456

Dynamics from Seconds to Hours in Hodgkin-Huxley Model with Time-Dependent Ion Concentrations and Buffer Reservoirs  

PubMed Central

The classical Hodgkin-Huxley (HH) model neglects the time-dependence of ion concentrations in spiking dynamics. The dynamics is therefore limited to a time scale of milliseconds, which is determined by the membrane capacitance multiplied by the resistance of the ion channels, and by the gating time constants. We study slow dynamics in an extended HH framework that includes time-dependent ion concentrations, pumps, and buffers. Fluxes across the neuronal membrane change intra- and extracellular ion concentrations, whereby the latter can also change through contact to reservoirs in the surroundings. Ion gain and loss of the system is identified as a bifurcation parameter whose essential importance was not realized in earlier studies. Our systematic study of the bifurcation structure and thus the phase space structure helps to understand activation and inhibition of a new excitability in ion homeostasis which emerges in such extended models. Also modulatory mechanisms that regulate the spiking rate can be explained by bifurcations. The dynamics on three distinct slow times scales is determined by the cell volume-to-surface-area ratio and the membrane permeability (seconds), the buffer time constants (tens of seconds), and the slower backward buffering (minutes to hours). The modulatory dynamics and the newly emerging excitable dynamics corresponds to pathological conditions observed in epileptiform burst activity, and spreading depression in migraine aura and stroke, respectively. PMID:25474648

Hübel, Niklas; Dahlem, Markus A.

2014-01-01

457

Nucleosynthesis in classical novae  

E-print Network

A general review of the relevance of classical novae for the chemical evolution of the Galaxy, as well as for Galactic radioactivity is presented. A special emphasis is put on the pioneering work done by Jim Truran in this field of research. The impact of recent developments in nuclear astrophysics on nova nucleosynthesis, together with the prospects for observability of novae radioactivities with the INTEGRAL satellite are discussed.

M. Hernanz; J. Jose; A. Coc

2001-01-19

458

Chinese Language and Culture Immersion for Rising 912 Graders  

E-print Network

Chinese Language and Culture Immersion for Rising 912 Graders Learn Chinese! Earn The Chinese Language and Culture Immersion Program is a crucial component of the Virginia STARTALK Chinese HISTORY The Chinese Language and Culture Immersion Program is created for the Virginia STARTALK Chinese

Acton, Scott

459

College of Arts and Sciences CHI Chinese Culture and Language  

E-print Network

College of Arts and Sciences CHI Chinese Culture and Language KEY: # = new course * = course CHINESE I. (4) A course in first semester Chinese language. CHI 102 BEGINNING CHINESE II. (4) A course in second semester Chinese language. Prereq: CHI 101 or equivalent. CHI 201 INTERMEDIATE CHINESE I. (4

MacAdam, Keith

460

[Computerized tomography in the staging and the follow-up of Hodgkin's lymphoma of the thorax].  

PubMed

As yet, the role of Computed Tomography (CT) as a routine imaging technique in the staging and follow-up of thoracic Hodgkin's disease has not been assessed. The authors report the results obtained in 120 patients affected with thoracic Hodgkin's disease, staged and followed by means of chest X-rays and CT. CT better identified intrathoracic involvement of mediastinal nodes, of lung parenchyma, of pleura, and of pericardial and chest walls in 54/120 patients (45%), with staging modifications in 18 (15%) of them only. Treatment was changed only in 12 patients (10%) where radiation therapy had been planned. The clinical value of the additional information yielded by CT was especially evident in the follow-up: CT allowed the correct evaluation of persistent/recurrent disease in 51/117 patients (43.5%), a figure high enough to suggest the use of CT in the routine follow-up of patients affected with thoracic Hodgkin's disease. PMID:2281167

Garribba, A P; Ettorre, G C; Francioso, G; Villani, P C; Angone, G; Liso, V; Specchia, G; Pavone, V; Capalbo, S

1990-12-01

461

In vivo somatic mutation in the lymphocytes of Hodgkin's disease patients  

SciTech Connect

While current medical therapies for Hodgkin's disease are usually quite effective, it has become increasingly clear that some of the therapies utilized carry an inherent risk for the induction of secondary malignancies. In order to examine the cellular and genetic responses to therapy for Hodgkin's disease among individuals, the authors have determined the mutant frequency of T-lymphocytes in 3 cohorts of patients and in controls using a T-cell cloning assay selecting for 6-thioguanine resistance. Overall, the results indicated that the individual response to Hodgkin's disease therapy was a heterogeneous one with a sub-population of persons having elevated mutant frequencies even many years after their last treatment. The larger frequency of elevated MFs in those patients who received intensive therapy (chemotherapy and radiotherapy) is consistent with their increased risk for second cancer induction.

Caggana, M.; Liber, H.L.; Mauch, P.M.; Coleman, C.N.; Kelsey, K.T. (Harvard Medical School, Boston, MA (United States))

1991-01-01

462

A note on the asymptotic reduction of the Hodgkin-Huxley equations for nerve impulses.  

PubMed

The (standard) FitzHugh reduction of the Hodgkin-Huxley equations for the propagation of nerve impulses ignores the dynamics of the activation gates. This assumption is invalid and leads to an over-estimation of the wave speed by a factor of 5 and the wrong dependence of wave speed on sodium channel conductance. The error occurs because a non-dimensional parameter, which is assumed to be small in the FitzHugh reduction, is in fact large (approximately 18). We analyse the Hodgkin-Huxley equations for propagating nerve impulses in the limit that this non-dimensional parameter is large, and show that the analytical results are consistent with numerical simulations of the Hodgkin-Huxley equations. PMID:15998489

Hinch, Robert

2005-09-01

463

GDP versus ESHAP Regimen in Relapsed and/or Refractory Hodgkin lymphoma: A Comparison Study  

PubMed Central

ABSTRACT Background: Despite multiple published studies reporting result of salvage regimens for relapsed and refractory Hodgkin's lymphoma, there are no comparisons of different combinations. Patients and methods: A Total of 44 patients identified with refractory or relapsed Hodgkin's Lymphoma were considered eligible for this study. The Patients were randomly divided into two groups of 22, one of which were treated with GDP regimen (gemcitabine, dexamethasone and cisplatin) and the other with EHSAP regimen (etoposide, methyl prednisolone, cisplatin and cytarabine) in a prospective manner. The results of each group were compared. Results: There were 27.3% complete response, 31.8% more than 50% response, and 40.9% no response with GDP. ESHAP results were 29.5%, 24% and 45.5%, respectively. Conclusion: There is no significant difference in response rate between GDP and ESHAP regimens as salvage chemotherapy in refractory or relapsed Hodgkin's Lymphoma. PMID:25802695

Ramzi, Mani; Dehghani, Mehdi

2015-01-01

464

Thyroid cancer following radiotherapy for Hodgkin's disease: a case report and review of the literature  

SciTech Connect

Improved survival resulting from advances in therapy in patients with Hodgkin's disease is associated with long-term morbidity, including the potential for the development of a second solid malignancy. We report a 44-year-old man with an unusually aggressive course of thyroid carcinoma 15 years after treatment for Hodgkin's disease. In a review of the English-language literature, we found 21 cases of thyroid cancer following radiotherapy for Hodgkin's disease, with latency periods ranging from 6 to 48 years. The development of secondary thyroid cancer after high-dose neck irradiation may be related to hypothyroidism, itself a complication of radiotherapy. Thyroid function should be measured at least once a year in all patients given neck irradiation, with initiation of thyroid hormone replacement if there is evidence of sustained hypothyroidism.

Moroff, S.V.; Fuks, J.Z.

1986-01-01

465

Research on machine translation oriented transformation from Chinese into Chinese sign language  

Microsoft Academic Search

Chinese sign language is a visual language. Chinese is a natural language. Research on translation from natural language into visual language is of practical and academic significance. In this paper Chinese sign language sentence structure is deeply analyzed. From the point of view of machine translation, the basic sentence patterns are classified into eight types. And transformation rules from Chinese

Xu Lin; Yuan Bao-zong; Gao Wen; Tang Xiao-fang; Xu Yan

2002-01-01

466

Chinese herbal medicines for hypercholesterolemia  

PubMed Central

Background Hypercholesterolemia is an important key contributory factor for ischemic heart disease and is associated with age, high blood pressure, a family history of hypercholesterolemia, and diabetes. Chinese herbal medicines have been used for a long time as lipid-lowering agents. Objectives To assess the effects of Chinese herbal medicines on hypercholesterolemia. Search strategy We searched the following databases: The Cochrane Library (issue 8, 2010), MEDLINE (until July 2010), EMBASE (until July 2010), Chinese BioMedical Database (until July 2010), Traditional Chinese Medical Literature Analysis and Retrieval System (until July 2010), China National Knowledge Infrastructure (until July 2010), Chinese VIP Information (until July 2010), Chinese Academic Conference Papers Database and Chinese Dissertation Database (until July 2010), and Allied and Complementary Medicine Database (until July 2010). Selection criteria We considered randomized controlled clinical trials in hypercholesterolemic participants comparing Chinese herbal medicines with placebo, no treatment, and pharmacological or non-pharmacological interventions. Data collection and analysis Two review authors independently extracted data and assessed the risk of bias. We resolved any disagreements with this assessment through discussion and a decision was achieved based by consensus. We assessed trials for the risk of bias against key criteria: random sequence generation, allocation concealment, blinding of participants, incomplete outcome data, selective outcome reporting and other sources of bias. Main results We included 22 randomized trials (2130 participants). The mean treatment duration was 2.3 ± 1.3 months (ranging from one to six months). Twenty trials were conducted in China and 18 trials were published in Chinese. Overall, the risk of bias of included trials was high or unclear. Five different herbal medicines were evaluated in the included trials, which compared herbs with conventional medicine in six comparisons (20 trials), or placebo (two trials). There were no outcome data in any of the trials on cardiovascular events and death from any cause. One trial each reported well-being (no significant differences) and economic costs. No serious adverse events were observed. Xuezhikang was the most commonly used herbal formula investigated. A significant effect on total cholesterol (two trial, 254 participants) was shown in favor of Xuezhikang when compared with inositol nicotinate (mean difference (MD) ?0.90 mmol/L, 95% confidence interval (CI) ?1.13 to ?0.68) . Authors’ conclusions Some herbal medicines may have cholesterol-lowering effects. Our findings have to be interpreted with caution due to high or unclear risk of bias of the included trials. PMID:21735427

Liu, Zhao Lan; Liu, Jian Ping; Zhang, Anthony Lin; Wu, Qiong; Ruan, Yao; Lewith, George; Visconte, Denise

2011-01-01

467

Mid-America Chinese Resource Guide  

E-print Network

The Mid-America Chinese Resource Guide is an Internet project of the Midwest Chapter Chinese American Librarians Association (CALA) which began in October 1997. The goal of this project is to create an online reference ...

Doll, Vickie

1998-01-01

468

Analysis of the Chinese college admission system   

E-print Network

This thesis focuses on the problems of the Chinese University Admission (CUA) system. Within the field of education, the system of university admissions involves all of Chinese society and causes much concern amongst all ...

Zhang, Haibo

2010-01-01

469

Second neoplasms in patients with Hodgkin's disease following combined modality therapy--the Yale experience  

SciTech Connect

From 1969 to 1982, 183 patients with previously untreated stages IIIB and IV Hodgkin's disease and relapsing Hodgkin's disease after radiation therapy were treated with combination chemotherapy plus low-dose irradiation (CRT). One hundred fifty patients who achieved a complete response (CR) were analyzed for risk of developing a second neoplasm. Median follow-up has been 8.3 years. Actuarial survival of all patients is 74% at 10 years with a relapse-free survival of 68%. An additional 24 patients with stage IIIA disease were also treated with CRT. There were 22 CRs at risk who were analyzed. Median follow-up has been 3+ years with an actuarial survival of 90% at five years and a relapse-free survival of 83%. Second neoplasms have developed in 14 of 172 patients at risk: acute nonlymphocytic leukemia (ANLL; five patients); aggressive histology non-Hodgkin's lymphoma (NHL; three patients); and a variety of solid neoplasms (six patients). Time to second neoplasm diagnosis after initial treatment ranged from 12 to 141 months. Five patients were older than 40 years. At the time of diagnosis of the second malignancy, 11 patients were free of Hodgkin's disease (for 36 to 141 months) and three were receiving therapy for recurrent Hodgkin's disease. The 10-year actuarial risk (%) of developing ANLL was 5.9 +/- 2.8; for NHL, the risk was 3.5 +/- 2.4, and for solid neoplasms, 5.8 +/- 3.0. Our results suggest that combination chemotherapy plus low-dose irradiation does not appear to significantly increase the risk of developing second neoplasms above that already reported for combination chemotherapy when administered as either initial or salvage treatment of Hodgkin's disease.

Koletsky, A.J.; Bertino, J.R.; Farber, L.R.; Prosnitz, L.R.; Kapp, D.S.; Fischer, D.; Portlock, C.S.

1986-03-01

470

Fenretinide and Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma  

ClinicalTrials.gov

Adult Nodular Lymphocyte Predominant Hodgkin Lymphoma; B-cell Chronic Lymphocytic Leukemia; Contiguous Stage II Adult Burkitt Lymphoma; Contiguous Stage II Adult Diffuse Large Cell Lymphoma; Contiguous Stage II Adult Lymphoblastic Lymphoma; Contiguous Stage II Grade 1 Follicular Lymphoma; Contiguous Stage II Grade 2 Follicular Lymphoma; Contiguous Stage II Mantle Cell Lymphoma; Stage II Marginal Zone Lymphoma; Stage II Small Lymphocytic Lymphoma; Extranodal Marginal Zone B-cell Lymphoma; Nodal Marginal Zone B-cell Lymphoma; Noncontiguous Stage II Adult Burkitt Lymphoma; Noncontiguous Stage II Adult Diffuse Large Cell Lymphoma; Noncontiguous Stage II Adult Lymphoblastic Lymphoma; Noncontiguous Stage II Grade 1 Follicular Lymphoma; Noncontiguous Stage II Grade 2 Follicular Lymphoma; Noncontiguous Stage II Mantle Cell Lymphoma; Recurrent Adult Burkitt Lymphoma; Recurrent Adult Diffuse Large Cell Lymphoma; Recurrent Adult Hodgkin Lymphoma; Recurrent Adult Lymphoblastic Lymphoma; Recurrent Grade 1 Follicular Lymphoma; Recurrent Grade 2 Follicular Lymphoma; Recurrent Mantle Cell Lymphoma; Recurrent Marginal Zone Lymphoma; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; Splenic Marginal Zone Lymphoma; Stage I Adult Burkitt Lymphoma; Stage I Adult Diffuse Large Cell Lymphoma; Stage I Adult Hodgkin Lymphoma; Stage I Adult Lymphoblastic Lymphoma; Stage I Chronic Lymphocytic Leukemia; Stage I Grade 1 Follicular Lymphoma; Stage I Grade 2 Follicular Lymphoma; Stage I Small Lymphocytic Lymphoma; Stage II Adult Hodgkin Lymphoma; Stage II Chronic Lymphocytic Leukemia; Stage III Adult Burkitt Lymphoma; Stage III Adult Diffuse Large Cell Lymphoma; Stage III Adult Hodgkin Lymphoma; Stage III Adult Lymphoblastic Lymphoma; Stage III Chronic Lymphocytic Leukemia; Stage III Grade 1 Follicular Lymphoma; Stage III Grade 2 Follicular Lymphoma; Stage III Mantle Cell Lymphoma; Stage III Marginal Zone Lymphoma; Stage III Small Lymphocytic Lymphoma; Stage IV Adult Burkitt Lymphoma; Stage IV Adult Diffuse Large Cell Lymphoma; Stage IV Adult Hodgkin Lymphoma; Stage IV Adult Lymphoblastic Lymphoma; Stage IV Chronic Lymphocytic Leukemia; Stage IV Grade 1 Follicular Lymphoma; Stage IV Grade 2 Follicular Lymphoma; Stage IV Mantle Cell Lymphoma; Stage IV Marginal Zone Lymphoma; Stage IV Small Lymphocytic Lymphoma; Waldenström Macroglobulinemia

2014-09-30

471

Impaired Cell-Mediated Immunity in Hodgkin's Disease Mediated by Suppressor Lymphocytes and Monocytes  

PubMed Central

In Hodgkin's disease a possible mechanism for impaired cellular immunity is cell-mediated suppression, defined as the inhibitory interaction between suppressor cells and effector lymphocytes. To test for the presence of suppressor cells in peripheral blood, we have modified the standard, one-way mixed lymphocyte culture by adding mitomycin C-treated mononuclear cells from the responder. Suppression, expressed as a percent of the base-line mixed lymphocyte culture in which these extra cells are not present, results in a reduction of thymidine incorporated in the modified culture (i.e., 100% suppression = no net thymidine incorporation; 0% suppression = identical thymidine incorporation in both the modified and baseline culture). Suppression was found to be significantly increased in patients with both active Hodgkin's disease (78±4.6%) and remission Hodgkin's disease (58±9.3%) compared to normal individuals (21±6.9%) (mean±SE). The degree and frequency of suppression were not influenced by disease stage or prior therapy. Cell purification techniques revealed (in 10 patients studied) the suppressor cell to be a monocyte in 6, and a thymus-derived lymphocyte in 4. Possible genetic restriction of the suppressor cell interaction was indicated by a failure of suppressor cells to alter the response of lymphocytes from unrelated individuals, but suppression was obtained with lymphocytes from a histocompatible sibling. Although mononuclear cells from normal individuals suppress less frequently than cells from patients with Hodgkin's disease, normals may demonstrate suppression comparable to that observed in Hodgkin's patients. This finding suggests that suppression is a normal immunoregulatory mechanism which is altered in Hodgkin's disease. PMID:149140

Hillinger, Stephen M.; Herzig, Geoffrey P.

1978-01-01

472

Drug-antibody pair has promising activity in non-Hodgkin lymphoma  

Cancer.gov

A toxin linked to a targeted monoclonal antibody has shown "compelling" antitumor activity in patients with non-Hodgkin lymphomas who were no longer responding to treatment, according to a report from Dana-Farber Cancer Institute. The ongoing open-label phase 2 study presented at the American Society of Hematology (ASH) meeting was designed to test the activity of brentuximab vedotin (Adcetris) in relapsed or refractory non-Hodgkin lymphoma (NHL) including B-cell cancers such as diffuse large B cell lymphoma (DLBCL).

473

Detection of Wolbachia genes in a patient with non-Hodgkin's lymphoma.  

PubMed

Wolbachia 16S rRNA and fbpA genes were twice detected over 5 days in the blood of a patient with high fever. The patient was given fluoroquinolones and the fever resolved. Four weeks later, he was diagnosed with non-Hodgkin's lymphoma and received R-CHOP (Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, Prednisolone) treatment resulting in complete remission. This is the first report of detection of Wolbachia genes from the blood of human patients with non-Hodgkin's lymphoma. PMID:25658559

Chen, X-P; Dong, Y-J; Guo, W-P; Wang, W; Li, M-H; Xu, J; Dumler, J S; Zhang, Y-Z

2015-02-01

474

Radiotherapy of stage I and II Hodgkin disease with inguinal presentation  

SciTech Connect

Seventeen patients who presented with inguinal adenopathy were found to have stage I or II infradiaphragmatic Hodgkin disease. Two patients with stage IIB disease also received MOPP chemotherapy. Fifteen patients currently have no evidence of recurrence; one died of acute myelogenous leukemia 6 years after total nodal irradiation, while another died of cardiopulmonary disease but had no evidence of Hodgkin disease at autopsy. In one patient, progressive peripheral atherosclerosis developed in an irradiated inguinal area, requiring angioplasty. Patient characteristics and results of treatment are analyzed and implications for management presented.

Lanzillo, J.H.; Moylan, D.J.; Mohiuddin, M.; Kramer, S.

1985-01-01

475

Karyotype in secondary hematologic disorders after treatment for Hodgkin's disease. A study of 19 patients  

SciTech Connect

In 19 cases of secondary hematologic disorders in patients previously treated for Hodgkin's disease, chromosome aberrations were analyzed in relation to the type of previous chemo- and/or radiotherapy, age of the patients, histopathologic features of the Hodgkin's disease at diagnosis, time interval between the treatment and the occurrence of the secondary disorder, and survival. The karyotype was of significant prognostic value when three cytogenetic groups were considered: patients with normal karyotypes; patients with aberrations of chromosome 7 as the sole anomaly; and patients with complex rearrangements and translocations. The last group showed the lowest rate of survival. Bone marrow transplantation was successful in two patients with a normal karyotype.

Iurlo, A.; Mecucci, C.; Van Orshoven, A.; Michaux, J.L.; Boogaerts, M.; Van den Berghe, H.

1988-12-01

476

[Filling the thymic space after treatment of Hodgkin's disease: rebound or relapse].  

PubMed

We report the case of a 36-year-old women with Hodgkin's disease treated with polychemotherapy and bone marrow autograft. Progressive growth of a thymic mass suggested possible relapse four months after treatment withdrawal. This mass did not exhibit gallium-67 uptake but showed strong affinity for 18-FDG (SUV=6.8). Surgical biopsy ruled out recurrence of Hodgkin's disease of the thymus and led to the diagnosis of thymic rebound. The aspect of the thymic compartment returned to normal spontaneously at one year. PMID:17457284

Margery, J; de Revel, T; Magois, E; Bonardel, G; Leduc, I; Saint-Blancard, P; Bonnichon, A; Vaylet, F; Jancovici, R; Nedellec, G

2007-02-01

477

Methotrexate-induced Hodgkin disease in a patient with systemic lupus erythematosus.  

PubMed

Methotrexate sodium use in the management of various immunologic disorders has increased--as have the number of reported adverse effects associated with this therapy. While methotrexate has helped combat various autoimmune and cancerous disorders, the paradoxical risk of causing an often fatal malignancy may still occur as a result of the drug's effect on suppressing immune function. We present a case of methotrexate-induced Hodgkin disease in a 48-year-old man with a history of systemic lupus erythematosus (SLE). Discontinuation of methotrexate facilitated Hodgkin disease reversal. In addition, we review other lymphoproliferative hematologic malignancies caused by methotrexate. PMID:19556391

Sliesoraitis, Sarunas; Khan, Rizwan; Rothman, Jan

2009-06-01

478

A New Chinese Speech Synthesis Method Apply in Chinese Poetry Learning  

Microsoft Academic Search

This paper describes a new Chinese speech synthesis method apply in Chinese poetry teaching and learning, which focus on the\\u000a prosody of syllables and words in Chinese poetry. As the word is a key semantic unit for Chinese poetry, we concentrate on\\u000a Chinese word prosody and propose a speech synthesis method, which consider the appearance with the essence of human

Chengsong Zhu; Yaoting Zhu

2008-01-01

479

Factors Influencing the Learning of Chinese Characters  

ERIC Educational Resources Information Center

This survey study, which involved 108 language learners enrolled in first-year Chinese as a foreign language classrooms in the United States, intended to address the research questions, "What types of Chinese-character learning strategies do US learners use?" and "Do US learners' Chinese-character learning strategy use differ based on the…

Sung, Ko-Yin; Wu, Hsiao-Ping

2011-01-01

480

Chinese-English Machine Translation System.  

ERIC Educational Resources Information Center

The report documents results of a two-year R&D effort directed at the completion of a prototype system for Chinese-English machine translation of S&T literature. The system, designated QUINCE, accepts Chinese input exactly as printed, with no pre-editing of any kind, and produces English output on experimental basis. Coding of Chinese text via…

Wang, William S-Y; And Others

481

Machine Translations of Chinese Mathematical Articles.  

ERIC Educational Resources Information Center

A practical machine translation system called CULT (Chinese University Language Translator), capable of translating Chinese mathematical texts into readable English, has been developed during the period 1969-1977 at the Chinese University of Hong Kong. Programs for the system are written in Standard FORTRAN and run on the ICL1904A computer system.…

Loh, Shiu-Chang; And Others

1978-01-01

482

The Chinese American: Inscrutable to Some.  

ERIC Educational Resources Information Center

Chinese Americans have been called inscrutable--not open to being understood. More casual, spontaneous, and expressive people find it hard to understand the strict discipline of feelings and highly selective and controlled expressions such as the Chinese American may practice. This paper serves as a social introduction to the Chinese American. For…

Chan, Carole

483

Problems of Textbook in Teaching Chinese Poetry.  

ERIC Educational Resources Information Center

It is proposed that teachers of Chinese expose their students to traditional critical views of Chinese poetics and criticism through careful selection of poems. This approach to language study is based on the assumption that the student may gain insight and appreciation of Chinese poetry as well as a feeling for the culture. Arguments favoring…

Kuo, Ta-hsia

484

First steps to literacy in Chinese classrooms  

Microsoft Academic Search

Chinese elementary schools bear the task of teaching the largest number of children in the world to read. Children learn to read and write Roman letters and pronounce Chinese syllables before they embark on the long task of learning Chinese characters. This process is followed in order to construct a national identity in a linguistically diverse country with numerous languages

John E. Ingulsrud; Kate Allen

2003-01-01

485

Saving Chinese-Language Education in Singapore  

ERIC Educational Resources Information Center

Three-quarters of Singapore's population consists of ethnic Chinese, and yet, learning Chinese (Mandarin) has been a headache for many Singapore students. Recently, many scholars have argued that the rhetoric of language planning for Mandarin Chinese should be shifted from emphasizing its cultural value to stressing its economic value since…

Lee, Cher Leng

2012-01-01

486

Bilingual Vocational Training Program for Chinese Chefs.  

ERIC Educational Resources Information Center

This document contains materials that can be used by instructors in an English-as-a-second-language course for Chinese kitchen workers or chefs. The materials consist of lessons on various topics that occur in the everyday life of Chinese chefs. Topics include: English names for Chinese dishes; phrases to employ when meeting people and when using…

China Inst. in America, New York, NY.

487

Chinese Checker Versions of the Pythagorean Theorem  

Microsoft Academic Search

In this paper, we give Chinese checker versions of the Pythagorean Theorem, and show that the converses of these Chinese checker versions of the Pythagorean Theorem are not true. Finally, we give a necessary and sufficient condition for a triangle in the Chinese checker plane to have a right angle. Mathematics Subject Classification: 51K05, 51K99

Rustem Kaya

488

Managerial Success Factors: A Chinese Profile  

ERIC Educational Resources Information Center

This article reports on an exploratory study conducted in the People's Republic of China (PRC) to identify the managerial success factors perceived by Chinese managers to be important in their market economy. The study also looked at how these factors are exhibited by recent graduates of Chinese universities now working in Chinese firms.…

Stivers, Bonnie P.; Adams, Janet S.; Liu, Bin

2007-01-01

489

Animals of the Chinese Zodiac. [Lesson Plan].  

ERIC Educational Resources Information Center

The Chinese lunar calendar dates back to the second millennium BC. Unlike the western calendar, which numbers the years progressively from the birth of Jesus Christ, the Chinese calendar is cyclical. Each cycle is made up of 12 years--after the 12th year, the cycle is repeated. The Chinese associate each year of a 12-year cycle with an animal, and…

2002

490