Sample records for chronic total occlusion

  1. [Chronic total occlusions].

    PubMed

    Galassi, Alfredo R; Tomasello, Salvatore D; Costanzo, Luca; Tamburino, Corrado

    2008-10-01

    Many studies showed that successful recanalization of chronic total occlusion (CTO) provides an improvement of long-term outcome and left ventricular ejection fraction, electrical stability of the myocardium, increased tolerance to future coronary events, and last but not least an improvement in quality of life. Because of the perceived procedural complexity of percutaneous coronary interventions (PCI), patients with CTO are usually referred to coronary artery bypass surgery or medical therapy. Recent advances in PCI materials, devices, approaches, and techniques have allowed expert operators to tackle successfully with complex cases of CTO that many years ago would have sent patients to surgery. This has also been motivated by the long-term patency and freedom from restenosis obtained by drug-eluting stent implantation. Each strategy and device has advantages and disadvantages, even though percutaneous treatment of CTO needs a higher operator's skill with respect to other non-occlusive lesions as well as an appropriate training period. In order to avoid complications and to achieve CTO recanalization in more than 70% of cases, it is advisable to understand the principles of each strategy, to plan the proper strategy and choose the appropriate materials, to take time, to be zen and aware when to stop. PMID:18942554

  2. Advances in Retrograde Technique for Coronary Chronic Total Occlusions

    PubMed Central

    DeMartini, Tony J.

    2014-01-01

    Despite a short lag period since its development the retrograde approach has been increasingly integrated within the treatment strategies for the percutaneous treatment of coronary chronic total occlusions. This review article discuss which anatomical features argue most powerfully for its use, the specific skills required for its uptake and the technology which has facilitated these developments. PMID:25311005

  3. Optical coherence tomography for imaging of chronic total occlusions

    NASA Astrophysics Data System (ADS)

    Munce, Nigel R.; Yang, Victor X. D.; Qiang, Beiping; Courtney, Brian K.; Brzozowski, Lukasz; Bakueva, Ludmilla; Mao, Linda Y.; Standish, Beau; Butany, Jagdish; Dick, Alexander J.; Strauss, Bradley H.; Wright, Graham A.; Vitkin, Alex

    2005-09-01

    Chronic total occlusions (CTOs) are defined as complete occlusions of an artery older than one month. Minimally invasive catheter-based interventions commonly employed for partial occlusions (e.g., balloon angioplasty followed by stenting) are problematic in CTOs because of the phycisian's inability to pass the device through the occlusion without a significant risk of arterial wall perforations. Furthermore, successfully treated CTOs exhibit a high re-occlusion rate. As a result, these cases are mostly sent to bypass surgery. With the advent of drug-eluting stents that reduce the incidence of re-occlusion, and thus, eliminating the second problem, new devices have begun to emerge that aim to recanalize CTOs without the cost and trauma of bypass surgery. These devices, however, need effective image guidance methods to ensure successful crossing of the CTOs. Optical coherence tomography (OCT) is being evaluated as an intravascular imaging modality for guiding catheter-based interventions of CTOs. Occluded ex vivo human arterial samples were used to produce longitudinal cross-sections using an OCT system. These OCT images were compared with histology to assess OCT's ability to identify different components of the occluded artery, evaluate the imaging depth, and determine the ability to detect the underlying vessel wall. Given the inherent difficulties of creating a mechanically scanning OCT probe in the distal tip of a catheter for use in a stenotic artery, we directed our initial efforts towards developing a "motionless" fiber based OCT system using a single mode fiber array. We discuss design considerations for implementing a forward viewing intravascular OCT probe.

  4. An update on coronary artery chronic total occlusions.

    PubMed

    Brayton, Kimberly; Mohammad, Atif; Brilakis, Emmanouil S; Banerjee, Subhash

    2012-02-01

    A coronary artery chronic total occlusion (CTO) represents a coronary artery that has been occluded for a long period of time, typically months. Coronary artery CTOs are common and occur in approximately one-third of patients referred for coronary angiography. Revascularization of CTO is technically challenging and has historically been associated with lower procedural success rates and higher complication rates. Technical success of CTO revascularization has significantly improved given remarkable advances in interventional cardiology over the past 3 decades. However, the decision to perform CTO revascularization remains a dilemma, given the lack of robust clinical evidence to support its use. PMID:22406899

  5. Knowledge of chronic total occlusion among Polish interventional cardiologists

    PubMed Central

    Zabojszcz, Micha?; D?bski, Grzegorz; Marchewka, Jakub; Legutko, Jacek; Surowiec, S?awomir; Siudak, Zbigniew; ?mudka, Krzysztof; Dudek, Dariusz; Bryniarski, Leszek

    2015-01-01

    Introduction Chronic total occlusion (CTO) recanalization is indicated in patients with symptoms and evidence of ischemia, but in most cases those types of lesions are still treated medically. In the last few years CTO angioplasty technique has changed dramatically due to considerable advances in techniques and dedicated equipment. Aim An attempt to assess the state of knowledge of technical aspects of CTO angioplasty of coronary arteries among Polish interventional cardiologists. Material and methods Questionnaire survey performed during two major Polish invasive cardiology workshops. Results In the study there participated 113 physicians with an average length of work experience of 13 years, most of them cardiologists certified as independent primary operators. The majority of respondents recognized the need of prevention of thrombotic complications through control of activated coagulation time during the CTO procedures. Prevention of renal complications and X-ray protection are also recognized as a significant part of the procedures. The benefits from the use of over-the-wire microcatheters and balloons, the proper choice of dedicated guidewires, contralateral injections and retrograde technique are underestimated. Conclusions Despite satisfactory knowledge about indications and qualification for the CTO procedure, the awareness of procedural aspects (particularly the retrograde technique) as well as the dedicated CTO equipment among Polish interventional cardiologists is still insufficient.

  6. The Evidence Base for Revascularisation of Chronic Total Occlusions

    PubMed Central

    Bagnall, Alan; Spyridopoulos, Ioakim

    2014-01-01

    When patients with ischaemic heart disease are considered for revascularisation the Heart Team’s aim is to choose a therapy that will provide complete relief of angina for an acceptable procedural risk. Complete functional revascularisation of ischaemic myocardium is thus the goal and for this reason the presence of a chronic total occlusion (CTO) - which remain the most technically challenging lesions to revascularise percutaneously - is the most common reason for selecting coronary artery bypass surgery [1]. From the behaviour of Heart Teams it is clear that physicians believe that CTOs are important. Yet when faced with patients with CTOs for whom surgery appears excessive (e.g. nonproximal LAD) or too high risk, there remains a reluctance to undertake CTO PCI, despite significant recent advances in procedural success and safety and a considerable body of evidence supporting a survival benefit following successful CTO PCI. This article reviews the relationship between CTOs, symptoms of angina, ischaemia and left ventricular dysfunction and further explores the evidence relating their treatment to improved quality of life and prognosis in patients with these features. PMID:24694105

  7. Extracellular volume fraction in coronary chronic total occlusion patients.

    PubMed

    Chen, Yin Yin; Zhang, Wei Guo; Yang, Shan; Yun, Hong; Deng, Sheng Ming; Fu, Cai Xia; Zeng, Meng Su; Jin, Hang; Guo, Liang

    2015-08-01

    (1) To assess extracellular volume fraction (ECV) and regional systolic function in patients presenting with coronary chronic total occlusion (CTO) in areas without significant late gadolinium enhancement (LGE), and (2) to investigate the correlation between angiography collateral flow and ECV in territories supplied by CTO vessels. A total of 50 angiographically documented CTO patients and 15 age- and sex-matched normal controls were recruited to the study. Myocardial ECV, was calculated in infarcted, global non-infarcted and the entire myocardium respectively. Segmental ECV was calculated from myocardial segments within the perfusion territory of a CTO vessel. The global and regional systolic function was evaluated using ejection fraction and percent systolic thickening. ECVs in global myocardium and global non-infarcted myocardium were significantly elevated in comparison with that in controls (29.1 ± 4.2 % and 26.6 ± 2.6 % vs. 23.3 ± 2.0 %, all P < 0.005). Global ECV significantly correlated with LV ejection fraction (r = -0.56, P < 0.001) and ECV inversely correlated with systolic thickening in global non-infarcted myocardium (r = -0.31, P < 0.05). The lower segmental ECV was associated with the presence of well-developed collaterals (P = 0.004), and multivariate binary logistic analysis demonstrated that mean segmental ECV and course of disease were the independent discriminator of collateral flow with overall diagnostic accuracy of 74.4 %. In patients with CTO, ECV is found to be increased beyond that observed with LGE, and correlates with LV regional wall motion abnormality, which appears to reflect diffuse myocardial fibrosis. Mean segmental ECV value, combined with course of disease, may serve as good predictors of collateral flow. PMID:25985941

  8. Photoluminescence-based detection of human chronic total occlusion in peripheral vessels

    NASA Astrophysics Data System (ADS)

    Bakueva, Ludmila; Brzozowski, Lukasz; Courtney, Brian; Reznik, Nikita; Fremes, Stephen E.; Rowlands, J. A.

    2005-09-01

    The work is devoted to photoluminescent investigation of arterial walls in order to create a new navigation method for minimally invasive treatment of cardiovascular decease in the presence of chronic total occlusions. The method uses the distinct photoluminescent properties of arterial wall and chronic total occlusion plaque to alert the interventionalist when a fiber-optic equipped catheter is in contact with the vessel wall. We conducted a study to compare the photoluminescence properties of healthy and stenosed vessel walls, and a typical chronic total occlusion plaque in the spectral range 300-700 nm. All samples were obtained from human tibial arteries. These groups of arterial samples showed easily differentiable luminescence amplitude and spectral characteristics. The photoluminescent properties of intact and intentionally damaged vessel walls were also investigated to permit detection of artery perforation that could take place during the revascularization. Using optical excitation of different wavelength gives additional opportunities of detecting arterial plaques requiring laser treatment. The results presented are complemented with micro-computed tomography images and histology of the segments analyzed.

  9. Chronic Total Occlusions in Sweden – A Report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR)

    PubMed Central

    Henriques, Jose P. S.; Dworeck, Christian; Angerås, Oskar; Odenstedt, Jacob; Ioanes, Dan; Olivecrona, Göran; Harnek, Jan; Jensen, Ulf; Aasa, Mikael; Jussila, Risto; James, Stefan; Lagerqvist, Bo; Matejka, Göran; Albertsson, Per; Omerovic, Elmir

    2014-01-01

    Introduction Evidence for the current guidelines for the treatment of patients with chronic total occlusions (CTO) in coronary arteries is limited. In this study we identified all CTO patients registered in the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) and studied the prevalence, patient characteristics and treatment decisions for CTO in Sweden. Methods and Results Between January 2005 and January 2012, 276,931 procedures (coronary angiography or percutaneous coronary intervention) were performed in 215,836 patients registered in SCAAR. We identified all patients who had 100% luminal diameter stenosis known or assumed to be ?3 months old. After exclusion of patients with previous coronary artery bypass graft (CABG) surgery or coronary occlusions due to acute coronary syndrome, we identified 16,818 CTO patients. A CTO was present in 10.9% of all coronary angiographies and in 16.0% of patients with coronary artery disease. The majority of CTO patients were treated conservatively and PCI of CTO accounted for only 5.8% of all PCI procedures. CTO patients with diabetes and multivessel disease were more likely to be referred to CABG. Conclusion CTO is a common finding in Swedish patients undergoing coronary angiography but the number of CTO procedures in Sweden is low. Patients with CTO are a high-risk subgroup of patients with coronary artery disease. SCAAR has the largest register of CTO patients and therefore may be valuable for studies of clinical importance of CTO and optimal treatment for CTO patients. PMID:25117457

  10. Surgical lead extraction for total occlusion of the superior vena cava by chronic lead infection after mustard procedure.

    PubMed

    Steinberg, Christian; Calvaruso, Davide; Guimond, Jean; Bédard, Elisabeth; Perron, Jean

    2014-05-01

    We present a case of total occlusion of the superior vena cava (SVC) with extensive thrombosis of the adjacent large veins secondary to multiple abandoned pacemaker leads with a superimposed chronic lead infection by Corynebacterium jeikeium. A surgical lead extraction was performed with an extensive en-bloc resection of the SVC together with the right subclavian vein and the right innomate vein. No venous reconstruction was required because of an unobstructed runoff via a well-developed azygos system. PMID:24438576

  11. Treating chronic total occlusions using subintimal tracking and reentry: the STAR technique.

    PubMed

    Colombo, Antonio; Mikhail, Ghada W; Michev, Iassen; Iakovou, Ioannis; Airoldi, Flavio; Chieffo, Alaide; Rogacka, Renata; Carlino, Mauro; Montorfano, Matteo; Sangiorgi, Giuseppe M; Corvaja, Nicola; Stankovic, Goran

    2005-04-01

    Successful recanalization of coronary total occlusions (CTOs) remains an area where improvements are needed. We propose an approach similar to the one utilized in treating some peripheral artery occlusions and aimed to create a subintimal dissection with distal reentry. A 0.014' hydrophilic wire with a J-configuration is utilized for this purpose. We applied this technique to CTO of native coronaries in 31 patients where previous attempts failed in 21 of them (67%). The right coronary artery (RCA) was the index vessel in 87% of patients. Recanalization of the vessel and of most of distal branches was achieved in 21 patients; patency of at least one major distal branch was achieved in 9 patients. Drug-eluting stents (DESs) were implanted in 53% of patients. Three patients had intraprocedural vessel perforation without consequences. Five patients (16%) had in-hospital non-Q-wave myocardial infarction. No other adverse events occurred at a mean follow-up of 5.1 +/- 3.7 months except for one noncardiac death. Angiographic follow-up was performed in 21 (67%) patients and 53% of them developed restenosis. Reintervention on the target vessel was performed in 11 patients (52%). Complete success with the procedure was originally obtained in 8 of the 10 patients who did not develop restenosis and in 8 of them DESs were originally implanted. This technique appears a promising approach to recanalize difficult total occlusions, particularly the ones localize on the RCA, which has the most important side branches located distally. PMID:15789384

  12. Initial and Long-Term Results of Endovascular Therapy for Chronic Total Occlusion of the Subclavian Artery

    SciTech Connect

    Babic, Srdjan, E-mail: sdrbabic@sezampro.rs [Institute for Cardiovascular Disease 'Dedinje,', Department of Vascular Surgery (Serbia); Sagic, Dragan [Institute for Cardiovascular Disease 'Dedinje', Department of Interventional Radiology (Serbia); Radak, Djordje [Institute for Cardiovascular Disease 'Dedinje,', Department of Vascular Surgery (Serbia); Antonic, Zelimir [Institute for Cardiovascular Disease 'Dedinje', Department of Interventional Radiology (Serbia); Otasevic, Petar [Institute for Cardiovascular Disease 'Dedinje', Department of Cardiology (Serbia); Kovacevic, Vladimir [Institute for Cardiovascular Disease 'Dedinje', Department of Interventional Radiology (Serbia); Tanaskovic, Slobodan; Ruzicic, Dusan; Aleksic, Nikola; Vucurevic, Goran [Institute for Cardiovascular Disease 'Dedinje,', Department of Vascular Surgery (Serbia)

    2012-04-15

    Purpose: To study the initial and long-term results of angioplasty and primary stenting for the treatment of chronic total occlusion (CTO) of the subclavian artery (SA). Materials and Methods: From January 1999 to February 2010, 56 patients (25 men with a mean age of 58 {+-} 8 years) underwent endovascular treatment for CTO of the SA. Duplex scans and arteriograms confirmed occlusion in all cases. Indications for recanalization were subclavian steal syndrome in 33 patients (58.1%), arm claudication in 13 patients (23.2%), and coronary ischemia in 7 patients (12.5%) who had a history of previous coronary artery bypass grafting that included left internal thoracic artery graft. Three patients (5.4%) were treated before the scheduled coronary artery bypass surgery, which included left internal thoracic artery graft. After successful recanalization, all arteries were stented, and all of the patients were followed-up at 1, 3, 6, and 12 months after surgery and annually thereafter. Results: Successful recanalization of the SA was achieved in 46 patients (82.1%), and the complication rate was 7.1%. During follow-up (mean 40 {+-} 26 months; range 2 to 125), the primary patency rates after 1 and 3 years were 97.9% and 82.7%, respectively. At the end of follow-up, 76% of the arteries showed no evidence of restenosis. Univariate analysis failed to identify any variable predictive of long-term patency of successfully recanalized SA. Conclusion: Percutaneous transluminal angioplasty with stenting of the complete total occlusion of the SA is a safe and effective procedure associated with low risks and good long-term results.

  13. Real-Time MRI-Guided Endovascular Recanalization of Chronic Total Arterial Occlusion in a Swine Model

    PubMed Central

    Raval, Amish N.; Karmarkar, Parag V.; Guttman, Michael A.; Ozturk, Cengizhan; Sampath, Smita; DeSilva, Ranil; Aviles, Ronnier J.; Xu, Minnan; Wright, Victor J.; Schenke, William H.; Kocaturk, Ozgur; Dick, Alexander J.; Raman, Venkatesh K.; Atalar, Ergin; McVeigh, Elliot R.; Lederman, Robert J.

    2006-01-01

    Background Endovascular recanalization (guidewire traversal) of peripheral artery chronic total occlusion (CTO) can be challenging. X-Ray angiography resolves CTO poorly. Virtually “blind” device advancement during X-ray-guided interventions can lead to procedure failure, perforation and hemorrhage. Alternatively, magnetic resonance imaging (MRI) may delineate the artery within the occluded segment to enhance procedural safety and success. We hypothesized that real-time MRI (rtMRI) guided CTO recanalization can be accomplished in an animal model. Methods and Results Carotid artery CTO was created by balloon injury in 19 lipid overfed swine. After 6–8 weeks, two underwent direct necropsy analysis for histology, three underwent primary X-ray-guided CTO recanalization attempts, and the remaining 14 underwent rtMRI-guided recanalization attempts in a 1.5T interventional MRI system. rtMRI intervention used custom CTO catheters and guidewires that incorporated MRI receiver antennae to enhance device visibility. The mean length of the occluded segments was 13.3 ± 1.6cm. rtMRI-guided CTO recanalization was successful in 11/14 swine and only 1/3 swine using X-ray alone. After unsuccessful rtMRI (n = 3), X-ray-guided attempts also were all unsuccessful. Conclusions Recanalization of long CTO is feasible entirely using rtMRI guidance. Low profile clinical-grade devices will be required to translate this experience to humans. Endovascular recanalization of chronic total arterial occlusion (CTO) is challenging under conventional X-ray guidance because devices are advanced almost blindly. MRI can image CTO borders and luminal contents, and could potentially guide these procedures. We test the feasibility of real-time MRI guided wire traversal in a swine model of peripheral artery CTO using custom active MRI catheters. PMID:16490819

  14. Multi-Modality Image Fusion to Guide Peripheral Artery Chronic Total Arterial Occlusion Recanalization in a Swine Carotid Artery Occlusion Model: Unblinding the Interventionalist!

    PubMed Central

    Klein, Andrew J.; Tomkowiak, Michael T.; Vigen, Karl K.; Hacker, Timothy A.; Speidel, Michael A.; VanLysel, Michael S.; Shah, Nehal; Raval, Amish N.

    2012-01-01

    Objectives To demonstrate the feasibility of magnetic resonance imaging (MRI) to x-ray fluoroscopy (XRF) image fusion to guide peripheral artery chronic total occlusion (CTO) recanalization. Background Endovascular peripheral artery CTO revascularization is minimally invasive, but challenging, because the occlusion is poorly visualized under XRF. Devices may steer out of the artery which can lead to severe perforation. Merging pre-acquired MRI of the CTO to the live XRF display may permit upfront use of aggressive devices and improve procedural outcomes. Methods Swine carotid artery CTO’s were created using a balloon injury model. Up to 8 weeks later, MRI of the carotid arteries was acquired and segmented to create 3D surface models, which were then registered onto live XRF. CTO recanalization was performed using incrementally aggressive CTO devices (Group A) or an upfront aggressive directed laser approach (Group B). Procedural success was defined as luminal or sub-intimal device position without severe perforation. Results In this swine model, MRI to XRF fusion guidance resulted in a procedural success of 57% in Group A and 100% in Group B, which compared favorably to 33% using XRF alone. Fluoroscopy time was significantly less for Group B (8.5 min ± 2.6 min) compared to Group A (48.7 min ± 23.9 min), p value<0.01. Contrast dose used was similar between Groups A and B. Conclusions MRI to XRF fusion guided peripheral artery CTO recanalization is feasible. Multi-modality image fusion may permit upfront use of aggressive CTO devices with improved procedural outcomes compared to XRF guided procedures. PMID:23097307

  15. Predictors of Chronic Total Occlusion in Nonculprit Artery in Patients With Acute Coronary Syndrome: Mean Platelet Volume and Uric Acid.

    PubMed

    Kurtul, Alparslan; Yarlioglues, Mikail; Murat, Sani Namik; Celik, ?brahim Etem; Demircelik, Muhammed Bora; Ocek, Adil Hakan; Duran, Mustafa; Ergun, Gokhan; Cetin, Mustafa; Ornek, Ender

    2015-07-01

    Chronic total occlusion (CTO) in a noninfarct-related artery (non-IRA) is an independent predictor of mortality in acute coronary syndrome (ACS). Mean platelet volume (MPV) and serum uric acid (SUA) are associated with cardiovascular events in ACS. We investigated the relationship between the presence of non-IRA-CTO with MPV and SUA levels in patients with ACS. Patients (n = 1024) who underwent urgent coronary angiography for ACS were included in this study. Blood samples were drawn on admission. Patients were categorized into 2 groups: non-IRA-CTO (-) and non-IRA-CTO (+). The MPV and SUA levels on admission were significantly higher in the non-IRA-CTO (+) group than in the non-IRA-CTO (-) group (P < .001). At multivariate analysis, MPV (odds ratio [OR]: 4.705, P < .001) and SUA (OR: 2.535, P < .001) were independent predictors of non-IRA-CTO together with age, hemoglobin, ejection fraction, and non-ST-segment elevation ACS. The MPV and SUA levels were significant and independent predictors for the presence of non-IRA-CTO in patients with ACS. PMID:25024462

  16. Comparison of Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusion Using Everolimus- Versus Sirolimus- Versus Paclitaxel-Eluting Stents (from the Korean National Registry of Chronic Total Occlusion Intervention).

    PubMed

    Lee, Min-Ho; Lee, Joo M; Kang, Si-Hyuck; Yoon, Chang-Hwan; Jang, Yangsoo; Yu, Cheol W; Park, Hun S; Lee, Seung-Hwan; Hur, Seung-Ho; Kim, Moo H; Rha, Seung-Woon; Gwon, Hyeon-Cheol; Chae, In-Ho; Kim, Hyo-Soo

    2015-07-15

    For the treatment of chronic total occlusion (CTO), the efficacy and safety of the everolimus-eluting stent (EES) remain less well defined. Also, there are limited data for the predictors of outcome after CTO intervention. The purpose of this study was to compare clinical outcomes of the EES with the first-generation drug-eluting stent (DES) in CTO intervention and to investigate the predictors of clinical outcome. The Korean National Registry of CTO Intervention is a retrospective cohort of 26 centers from the past 5 years. The primary end point was major adverse cardiovascular events (MACE) defined as a composite of cardiac death, nonfatal myocardial infarction, and target lesion revascularization. Of the 1,754 all-comer patients, 1,509 patients (EES 311, sirolimus-eluting stent [SES] 642, paclitaxel-eluting stent 556) were finally analyzed after excluding 245 patients (mixed DESs in 46 and follow-up loss in 199). In the inverse probability weighting-adjusted population, the 1-year MACE rate of the EES was comparable with that of the SES (5.8% vs 3.4%, p = 0.796) and the paclitaxel-eluting stent (5.8% vs 6.9%, p = 0.740). Each component of MACE was also comparable among the 3 stents. Importantly, the independent predictors of MACE were diabetes mellitus, previous congestive heart failure, and left circumflex CTO. In conclusion, for the first time in the largest CTO cohort, the EES showed good 1-year clinical outcomes that were comparable with the SES. Independent predictors of MACE after CTO intervention were clinical factors (diabetes and congestive heart failure) and lesion location. PMID:26001819

  17. Impact of diabetes on long term follow-up of elderly patients with chronic total occlusion post percutaneous coronary intervention

    PubMed Central

    Liu, Wei; Wagatsuma, Kenji; Nii, Hideo; Toda, Mikihito; Amano, Hideo; Uchida, Yasuto

    2013-01-01

    Background The prognosis of elderly patients with chronic total occlusion (CTO) and diabetes mellitus (DM) treated with percutaneous coronary intervention (PCI) is not known. Objective To investigate the effect of diabetes on long-term follow-up of CTO after PCI in elderly patients. Methods A total of 153 elderly patients (age > 65 years old) with CTO lesions which were successfully treated with PCI were enrolled. Fifty one patients with diabetes and 102 without diabetes were compared for long-term outcomes (mean follow up: 36 ± 12 months). Major adverse cardiac events (MACE) which include death, myocardial infarction or target lesion revascularization (TLR) were considered as a combined endpoint. Results The combined endpoint occurred in 29.4% of diabetes patients, and 11.3% of the patients without diabetes (P < 0.05). The Cox proportional hazards model identified: drug eluting stent (DES) or bare metal stent (BMS) (HR: 0.13, 95% confidence interval (95% CI): 0.03–0.62, P = 0.004), DM (HR: 6.69, 95% CI: 1.62–15.81, P = 0.01) and final minimal lumen diameter (MLD) (HR: 0.37, 95% CI: 0.13–0.90, P = 0.03 ) as independent predictors of MACE, DM with renal impairment (HR: 6.64, 95% CI: 1.32–33.36, P = 0.02), HBA1C on admission (HR: 1.79, 95% CI: 1.09–2.94, P = 0.02), as independent predictors of MACE at long term follow-up. Conclusions The study demonstrates that DM is a predictive factor for MACE in elderly CTO patients treated with PCI, type of stent, final minimal lumen diameter and DM with renal impairment, and HBA1C level on admission are predictors of MACE. PMID:23610569

  18. Meta-analysis of clinical outcomes of patients who underwent percutaneous coronary interventions for chronic total occlusions.

    PubMed

    Christakopoulos, Georgios E; Christopoulos, Georgios; Carlino, Mauro; Jeroudi, Omar M; Roesle, Michele; Rangan, Bavana V; Abdullah, Shuaib; Grodin, Jerrold; Kumbhani, Dharam J; Vo, Minh; Luna, Michael; Alaswad, Khaldoon; Karmpaliotis, Dimitri; Rinfret, Stephane; Garcia, Santiago; Banerjee, Subhash; Brilakis, Emmanouil S

    2015-05-15

    Successful percutaneous coronary intervention (PCI) for chronic total occlusions (CTOs) has been associated with clinical benefit. There are no randomized controlled trials on long-term clinical outcomes after CTO PCI, limiting the available evidence to observational cohort studies. We sought to perform a weighted meta-analysis of the long-term outcomes of successful versus failed CTO PCI. A total of 25 studies, published from 1990 to 2014, with 28,486 patients (29,315 CTO PCI procedures) were included. We analyzed data on mortality, subsequent coronary artery bypass grafting (CABG), myocardial infarction, major adverse cardiac events, angina pectoris, stroke, and target vessel revascularization using random-effects models. Procedural success was 71% (range 51% to 87%). During a weighted mean follow-up of 3.11 years, compared with unsuccessful, successful CTO PCI was associated with lower mortality (odds ratio [OR] 0.52, 95% confidence interval [CI] 0.43 to 0.63), less residual angina (OR 0.38, 95% CI 0.24 to 0.60), lower risk for stroke (OR 0.72, 95% CI 0.60 to 0.88), less need for subsequent coronary artery bypass grafting (OR 0.18, 95% CI 0.14 to 0.22), and lower risk for major adverse cardiac events (0.59, 95% CI 0.44 to 0.79). There was no difference in the incidence of target vessel revascularization (OR 0.66, 95% CI 0.36 to 1.23) or myocardial infarction (OR 0.73, 95% CI 0.52 to 1.03). Outcomes were similar in patients who underwent balloon angioplasty only or stenting with bare metal or drug-eluting stents. Compared with failed procedures, successful CTO PCIs are associated with a lower risk of death, stroke, and coronary artery bypass grafting and less recurrent angina pectoris. PMID:25784515

  19. Corsair microcatheter for retrograde coronary chronic total occlusion recanalization: Early experience outside the realm of dedicated recanalization specialists

    PubMed Central

    Joseph, George; Thomson, Viji Samuel; Radhakrishnan, Shanmugasundaram

    2012-01-01

    Objective To determine the extent to which use of the Corsair microcatheter (CM, Asahi Intecc Co., Japan) improves procedural outcomes when an experienced operator who is not a dedicated recanalization specialist attempts retrograde chronic total occlusion (CTO) recanalization through collateral channels during percutaneous coronary intervention. Background The recently introduced CM has improved success rates of retrograde CTO recanalization to nearly 100% in the hands of dedicated coronary recanalization specialists; however, the impact the CM has on the results of non-specialist operators attempting retrograde CTO recanalization is not known. Methods A non-specialist operator attempted CM-assisted recanalization in seven consecutive CTO cases requiring retrograde recanalization. The results obtained were compared with those achieved by the same operator in eleven consecutive retrograde CTO recanalization procedures during the last 2 years before the CM became available. Results CM-assisted retrograde CTO recanalization was successful in 6 of 7 cases (86%), but failed in one case attempted through a tortuous epicardial collateral; there were no complications. In contrast, during the 2 years before the CM became available, retrograde CTO recanalization was successful in only 3 of 11 attempted cases (27%), and was associated with significant morbidity. Lesions in the two groups were comparable in terms of technical difficulty and procedural risk. Conclusions The non-specialist operator's retrograde CTO recanalization results improve significantly when using the CM. Given the effectiveness and safety of CM-assisted retrograde CTO recanalization, operators should be less aggressive with anterograde recanalization attempts, and should switch to the retrograde approach earlier and more often. PMID:22929822

  20. Elevated survivin expression in peripheral blood mononuclear cells is central to collateral formation in coronary chronic total occlusion.

    PubMed

    Xu, Yiguan; Tan, Xuerui; Wang, Dongming; Wang, Wei; Li, Yuguang; Wu, Min; Chen, Songming; Wu, Yinge; Tan, Chunjiang

    2015-06-01

    Survivin is essential to angiogenesis and revascularization, but its role in coronary collateral formation remains unclear. The role of survivin in peripheral blood mononuclear cells (PBMCs) of coronary chronic total occlusion (CTO) patients was investigated. Coronary CTO patients (n=46; mean age 60.1±8.5, male 54.3%) (CTO group) and normal control patients (n=18; mean age 58.0±10.0, male 55.6%) underwent angiographic collateral vessel grading by Rentrop classification (C0 - C3) and provided peripheral blood between June 2006 and February 2007. Rat hind limb ischemia models were constructed using four equal groups of Sprague-Dawley rats (n=36): normal control, sham operation, operation and granulocyte macrophage colony-stimulating factor (GM-CSF). PBMC numbers and characteristics, collateral vessels, survivin, CD4, CD8, CD44, vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) expression were determined using RT-PCR, flow cytometry, immunocytochemistry and western blot analysis. PBMC survivin mRNA and protein expression levels were higher in patients with good collateral circulation (C2 + C3) than in patients with no collateral flow (C0) (all P<0.05). Survivin single-positive and survivin and CD8, VEGF and ICAM-1 double-positive percentages were elevated in patients with good collateral circulation compared to those with normal and no collateral flow (all P<0.05), consistent with the rat model results, wherein higher survivin levels produced significantly larger and more visible collateral vessels. In conclusion, elevated survivin expression in PBMCs, particularly survivin and CD8, VEGF, and ICAM-1 double-positive PBMCs, may be crucial for good collateral formation in patients with coronary CTO, as confirmed by assessment of a rat model. PMID:25816072

  1. Elevated survivin expression in peripheral blood mononuclear cells is central to collateral formation in coronary chronic total occlusion

    PubMed Central

    XU, YIGUAN; TAN, XUERUI; WANG, DONGMING; WANG, WEI; LI, YUGUANG; WU, MIN; CHEN, SONGMING; WU, YINGE; TAN, CHUNJIANG

    2015-01-01

    Survivin is essential to angiogenesis and revascularization, but its role in coronary collateral formation remains unclear. The role of survivin in peripheral blood mononuclear cells (PBMCs) of coronary chronic total occlusion (CTO) patients was investigated. Coronary CTO patients (n=46; mean age 60.1±8.5, male 54.3%) (CTO group) and normal control patients (n=18; mean age 58.0±10.0, male 55.6%) underwent angiographic collateral vessel grading by Rentrop classification (C0 – C3) and provided peripheral blood between June 2006 and February 2007. Rat hind limb ischemia models were constructed using four equal groups of Sprague-Dawley rats (n=36): normal control, sham operation, operation and granulocyte macrophage colony-stimulating factor (GM-CSF). PBMC numbers and characteristics, collateral vessels, survivin, CD4, CD8, CD44, vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) expression were determined using RT-PCR, flow cytometry, immunocytochemistry and western blot analysis. PBMC survivin mRNA and protein expression levels were higher in patients with good collateral circulation (C2 + C3) than in patients with no collateral flow (C0) (all P<0.05). Survivin single-positive and survivin and CD8, VEGF and ICAM-1 double-positive percentages were elevated in patients with good collateral circulation compared to those with normal and no collateral flow (all P<0.05), consistent with the rat model results, wherein higher survivin levels produced significantly larger and more visible collateral vessels. In conclusion, elevated survivin expression in PBMCs, particularly survivin and CD8, VEGF, and ICAM-1 double-positive PBMCs, may be crucial for good collateral formation in patients with coronary CTO, as confirmed by assessment of a rat model. PMID:25816072

  2. Subintimal Angioplasty of Long Chronic Total Femoropopliteal Occlusions: Long-Term Outcomes, Predictors of Angiographic Restenosis, and Role of Stenting

    SciTech Connect

    Siablis, Dimitris, E-mail: siablis@upatras.gr; Diamantopoulos, Athanasios; Katsanos, Konstantinos; Spiliopoulos, Stavros [Patras University Hospital, Department of Radiology, Angiography Suite (Greece); Kagadis, George C. [Patras School of Medicine, Department of Medical Physics (Greece); Papadoulas, Spyros [Patras University Hospital, Department of Vascular Surgery (Greece); Karnabatidis, Dimitris [Patras University Hospital, Department of Radiology, Angiography Suite (Greece)

    2012-06-15

    Purpose: The purpose of this article is to report the results of a prospective single-center study analyzing the long-term clinical and angiographic outcomes of subintimal angioplasty (SIA) for the treatment of chronic total occlusions (CTOs) of the femoropopliteal artery. Materials and Methods: Patients with severe intermittent claudication or critical limb ischemia (CLI) were enrolled in the study. All lesions were treated with SIA and provisional stenting. Primary end points were technical success, patient survival, limb salvage, lesion primary patency, angiographic binary restenosis (>50%), and target lesion revascularization (TLR). Regular clinical and angiographic follow-up was set at 6 and 12 months and yearly thereafter. Study end points were calculated with life-table survival analysis. Proportional-hazards regression analysis with a Cox-model was applied to adjust for confounding factors of heterogeneity. Results: Between May 2004 and July 2009, 98 patients (105 limbs, patient age 69.3 {+-} 9.9 years) were included in the study. Technical success rate was 91.4% with a lesion length of 121 {+-} 77 mm. Limb-salvage and survival rates were 88.7% and 84.1% at 3 years, respectively. After 12, 24, and 36 months, primary patency was 80.1%, 42.3%, and 29.0%, angiographic binary restenosis was 37.2%, 68.6%, and 80.0%, and TLR was 84.8%, 73.0%, and 64.5%, respectively. CLI was the only adverse predictor for decreased primary patency (hazard ratio [HR] 0.36; 95% confidence interval [CI] 0.16-0.80, p = 0.012), whereas significantly less restenosis was detected after spot stenting of the entry and/or re-entry site (HR 0.31; 95% CI 0.10-0.89, p = 0.01 and HR 0.20; 95% CI 0.07-0.56, p = 0.002, respectively). Conclusions: Subintimal angioplasty is a safe and effective revascularization technique for the treatment of CTOs of the femoropopliteal artery. Provisional stenting may have a role at the subintimal entry or true lumen re-entry site.

  3. A successful treatment for a lesion of chronic total occlusion with contralateral angiography in a single radial access.

    PubMed

    Nakamura, Reo; Ota, Keisuke; Isoda, Kei; Miyai, Nobuyuki; Sawanishi, Takayoshi; Kinoshita, Noriyuki

    2015-01-01

    A 50-year-old man was admitted due to effort chest pain. Coronary angiogram showed a total occlusion of LAD. The 5-French JL 3.5 was engaged into the left coronary artery. The XT-A guidewire was advanced to the distal of the occluded lesion. Contralateral angiography was performed using JL 3.5. The guiding catheter was pullback from the left coronary orifice leaving the guidewire at LAD, and the catheter tip was rotated clockwise to right coronary cusp for right coronary angiography. We could confirm that the guidewire was in the true lumen vessel. PMID:24639100

  4. Predicting successful percutaneous coronary intervention in patients with chronic total occlusion: the incremental value of a novel morphological parameter assessed by computed tomography.

    PubMed

    Chen, Yang; Lu, Bin; Hou, Zhi-Hui; Gao, Yang; Yu, Fang-Fang; Yin, Wei-Hua; Wang, Zhi-Qiang

    2015-08-01

    To study the relationship between percutaneous coronary intervention (PCI) success and various morphological index evaluated by coronary computed tomography angiography (CCTA) in patients with coronary chronic total occlusion (CTO). 272 Consecutive patients with 281 CTO lesions diagnosed by CCTA and invasive coronary angiography were prospectively enrolled. The luminal attenuation of proximal segment of CTO lesions was measured. Other parameters, like lesion length, coronary calcium score, torturous course, stump morphology were also recorded. The attenuation of the proximal segment of CTO lesions was significantly higher in PCI failure group than it was in PCI success group (88 ± 19.7 vs. 70.2 ± 13, p < 0.001). Lesion length in PCI failure group was longer than those in PCI success group (20.4 ± 11.2 vs. 15.1 ± 5.85 mm, p < 0.001) and lesions in PCI failure group were more heavily calcified than lesions in PCI success group (Agatston score 61 vs. 5.7, p < 0.001). The attenuation of the proximal segment of CTO lesions, along with occlusion length and total coronary calcium score were significant independent predictors of PCI failure. The attenuation of the proximal segment of CTO lesions, along with occlusion length and total coronary calcium score as assessed by CCTA have predictive value for PCI outcomes. PMID:25982175

  5. The innovation of composite core dual coil coronary guide-wire technology: A didactic coronary chronic total occlusion revascularization case report.

    PubMed

    Tomasello, Salvatore Davide; Giudice, Pietro; Attisano, Tiziana; Boukhris, Marouane; Galassi, Alfredo R

    2014-10-01

    The treatment of coronary chronic total occlusions (CTO) continues to solicit technical innovations. As success primarily depends on crossing the lesion with a wire, all aspects regarding tip shape retention, torque precision, and penetration ability of the guide-wire have greatly influenced new techniques and strategies. The world of interventional cardiology has to look carefully at these developments, and to use them accordingly to improve the success rate in ordinary percutaneous coronary interventions. We present a didactical case report of a CTO revascularization treated with a new 'dual core' technology guide-wire. PMID:25278725

  6. High-Resolution 3D Arteriography of Chronic Total Peripheral Occlusions Using a T1-W Turbo Spin-Echo Sequence With Inner-Volume Imaging

    PubMed Central

    Sampath, Smita; Raval, Amish N.; Lederman, Robert J.; McVeigh, Elliot R.

    2007-01-01

    Percutaneous revascularization of peripheral artery chronic total occlusion (CTO) is challenging under X-ray guidance without direct image feedback, due to poor visualization of the obstructed segment and underappreciation of vessel tortuosity. Operators are required to steer interventional devices relatively “blindly,” and therefore procedural failure or perforation may occur. Alternatively, MRI may allow complete visualization of both patent and occluded arterial segments. We designed and implemented a 3D high-resolution, T1-weighted (T1-W) turbo spin-echo (TSE) MRI sequence with inner-volume (IV) imaging to enable detailed peripheral artery CTO imaging. Using this sequence, high-resolution volumes of interest (VOIs) around the vessel were achieved within 5-10 min. This imaging approach may be used for rapid pre- and postprocedural evaluations, and as a 3D roadmap that can be overlaid during real-time X-, MR-, or XMR-guided catheterization. Experiments were successfully performed on a carotid CTO model in swine ex vivo, and in peripheral arteries in normal volunteers and patients in vivo. Delineation of the vascular architecture, including contrast differences between the patent and occluded artery segments, and lesion morphology heterogeneity were visualized. PMID:17152076

  7. Clinical Significance of A Single Multi-Slice CT Assessment in Patients with Coronary Chronic Total Occlusion Lesions Prior to Revascularization

    PubMed Central

    Qu, Xinkai; Fang, Weiyi; Gong, Kaizheng; Ye, Jianding; Guan, Shaofeng; Li, Ruogu; Xu, Yingjia; Shen, Yan; Zhang, Min; Liu, Hua; Xie, Wenhui

    2014-01-01

    Accurate assessment of coronary chronic total occlusion (CTO) lesion is essential to design an appropriate procedural strategy before revascularization. The present study aims to evaluate the significance of a single multislice computed tomography (MSCT) examination in patients with CTO lesion. We retrospectively analyzed the clinical data of 23 CTO lesions in twenty patients underwent computed tomography coronary angiography (CTCA) and SPECT. The CTCA was more powerful and sensitive to determine the CTO lesion length (100% v.s 47.8%) and to identify the length and location of calcification in occluded vessels compared with the coronary angiography (CAG). The LVEF measured by MSCT was comparable to that from the gated SPECT. Myocardial perfusion imaging showed that the location of the early defect region identified by MSCT was corresponded to the nuclide filling defect on the stressed 201thallium-SPECT imaging. The late hyperenhancement on MSCT was presented as incomplete nuclide filling on the 99mTc-MIBI imaging. The results suggested that a single MSCT examination in previous myocardial infarction without revascularization facilitates to provide some valuable information on the nature of the occluded lesion, myocardial perfusion and globe cardiac function, which would be helpful to design appropriate revascularization strategy in these subjects. PMID:24905494

  8. Immediate- and short-term outcome following recanalization of long chronic total occlusions (> 50 mm) of native coronary arteries with the Frontrunner catheter.

    PubMed

    Loli, Akil; Liu, Rex; Pershad, Ashish

    2006-06-01

    Thirty percent of diagnostic angiograms have at least 1 chronic total occlusion (CTO). The 10-year survival of patients with a CTO is improved if they have the CTO successfully recanalized. The success of recanalization with conventional wires is 50% and the impact of new technology on recanalization is unknown. This abstract reports a single center experience with one such new device, the Lumend Frontrunner catheter in revascularization of this difficult lesion subset. A consecutive series of 18 patients with CTO's of native coronary arteries were enrolled in this single center, single operator series. The mean age of the CTO was 5.3 years. The indication for attempt at recanalization was ischemia in the territory of the CTO on SPECT imaging. Success was defined as TIMI flow restoration and < 40% residual stenosis. Primary success (defined as TIMI 3 Flow restoration and < 40% residual stenosis) was achieved in 77% of patients. At 30 days and out to 6 months, clinical TVR was 11% (2/18) in this difficult lesion subset. Conventional predictors of failure to recanalize CTOs do not appear to hold true with the use of the Frontrunner catheter. In this small series, dual cusp injections and use of the Microglide catheter appears to correlate with favorable outcomes. Fluoroscopy times and contrast use are high when attempting recanalization of CTOs with this technology. PMID:16775901

  9. The age, creatinine, and ejection fraction score to risk stratify patients who underwent percutaneous coronary intervention of coronary chronic total occlusion.

    PubMed

    Di Serafino, Luigi; Borgia, Francesco; Maeremans, Joren; Pyxaras, Stylianos A; De Bruyne, Bernard; Wijns, William; Heyndrickx, Guy; Dens, Jo; Di Mario, Carlo; Barbato, Emanuele

    2014-10-15

    Age, creatinine, and ejection fraction (ACEF) score predict clinical outcomes in patients who underwent elective percutaneous coronary intervention (PCI) of nonocclusive coronary stenoses. We aimed at assessing the prognostic value of the ACEF score in patients who underwent successful PCI of chronic total occlusion (CTO). ACEF score was calculated in 587 patients treated with PCI of CTO: successful in 433 (74%; success group) and failed in 154 patients (26%; failure group). Patients were divided in ACEF tertiles: first <0.950, second from 0.950 to 1.207, and third ACEF tertile >1.207. Major adverse cardiac events (MACE = overall death + nonfatal myocardial infarction + clinically driven target vessel revascularization) were assessed in 558 patients (95%) up to 24 months (8 to 24 months). In success group, higher MACE rate was significantly associated with increasing ACEF tertile (first = 7%, second = 13%, third ACEF = 18%, p = 0.02). MACE-free survival was significantly decreased with increasing ACEF tertile (log-rank 5.58, p = 0.018). In the failure group, lower MACE rate was significantly associated with increasing ACEF tertile (p = 0.041). This was mainly driven by significant decreasing rate of target vessel revascularization along the tertiles (first = 34%, second = 19%, third ACEF = 10%, p = 0.007). Compared with success group, in failure group, MACE rate was significantly higher in the first tertile (p <0.001) and similar in the third tertile (p = 0.59). In conclusion, ACEF score represents a simple tool in the prognostication of patients successfully treated with PCI of CTO and identifies those patients who would not derive any significant clinical harm despite failed percutaneous revascularization of the CTO. PMID:25152423

  10. Evaluation of the Effect of Concurrent Chronic Total Occlusion and Successful Staged Revascularization on Long-Term Mortality in Patients with ST-Elevation Myocardial Infarction

    PubMed Central

    Shi, Guoxiang; He, Pengcheng; Liu, Yuanhui; Lin, Yaowang; Yang, Xing; Chen, Jiyuan; Zhou, Yingling; Tan, Ning

    2014-01-01

    Aims. To investigate the impact of chronic total occlusion (CTO) in non-infarct-related artery (IRA) on the long-term prognosis and evaluate the clinical significance of staged revascularization in patients with ST-segment elevation myocardial infarction (STEMI). Methods. 1266 STEMI patients with primary percutaneous coronary intervention (PCI) were categorized as single-vessel disease (SVD), multivessel disease (MVD) without and with CTO. We study the clinical outcomes of patients after primary PCI in the following 3 years. Additionally, patients with CTO received staged revascularization, and major adverse cardiac events (MACE) during 3-year follow-up were recorded. Results. Presence of CTO was a predictor of both early mortality [hazard ratio (HR) 3.4, 95% confidence interval (CI) 2.4–4.5, P < 0.01] and late mortality (HR 1.9, 95% CI 1.4–3.6, P < 0.01), whereas MVD without CTO was only a predictor of early mortality (HR 1.7, 95% CI 1.3–2.3, P < 0.05). In CTO group, 100 patients had successful CTO recanalization, and 48 patients failed. During 3-year follow-up, patients with failed procedure had higher cardiac mortality (22.9% versus 9.0%, P = 0.020) and lower MACE-free survival (50.0% versus 72.0%, P = 0.009) compared to patients with successful procedure. Conclusion. The presence of CTO and not MVD alone is associated with long-term mortality. Successful revascularization of CTO in the non-IRA is associated with improved clinical outcomes in patients with STEMI undergoing primary PCI. PMID:24790581

  11. Meta-Analysis of the Impact on Mortality of Noninfarct-Related Artery Coronary Chronic Total Occlusion in Patients Presenting With ST-Segment Elevation Myocardial Infarction.

    PubMed

    O'Connor, Stephen A; Garot, Philippe; Sanguineti, Francesca; Hoebers, Loes P; Unterseeh, Thierry; Benamer, Hakim; Chevalier, Bernard; Hovasse, Thomas; Morice, Marie-Claude; Lefèvre, Thierry; Louvard, Yves

    2015-07-01

    Several observational studies have compared clinical outcome in patients with a co-existing noninfarct-related artery chronic total occlusion (n-IRA CTO) versus those without, suggesting increased all-cause mortality. The goal of this study was to provide a systematic review and meta-analysis evaluating the impact of the presence of an n-IRA CTO on short- and long-term mortality after primary percutaneous coronary intervention. Studies published from January 1980 to January 2014 that compared the incidence of all-cause mortality in patients with ST-segment elevation myocardial infarction with co-existing n-IRA CTO versus those without were identified using an electronic search and reviewed using meta-analytical techniques. Seven studies (5 observational studies and 2 observational analyses of randomized controlled trials) comprising 14,117 patients and 1,554 patients (11.7%) with n-IRA CTO were included. The presence of n-IRA CTO was associated with increased incidence of all-cause mortality at a median follow-up of 25.2 months (interquartile range 24 to 60) compared with no CTO (absolute risk 23.5% vs 9.0%; odds ratio [OR] 2.90, 95% confidence interval [CI] 2.09 to 4.01; p <0.0001). This finding was consistent in the analysis of studies reporting 30-day follow-up (absolute risk 17.2% vs 4.7%; OR 3.79, 95% CI 3.13 to 4.59; p <0.0001). Co-existing n-IRA CTO was also associated with increased mortality in a subanalysis of patients with multivessel disease only (absolute risk 24.2% vs 11.3%; OR 2.23, 95% CI 1.90 to 2.63; p <0.0001). In conclusion, coronary CTO in the nonculprit artery in patients presenting with ST-segment elevation myocardial infarction is associated with increased short- and long-term all-cause mortality. PMID:26068700

  12. Chronic coronary occlusions: age, morphology and chance of reopening.

    PubMed Central

    Vallbracht, C; Unverdorben, M; Kadel, C; Oster, H; Otto, J; Kober, G; Kaltenbach, M

    1997-01-01

    In chronic coronary occlusions the chance of successful reopening by angioplasty can be judged from the age of the occlusion. Often, however, time since occlusion cannot be accurately assessed. Therefore we determined whether the chance of reopening can be predicted from angiographic morphology. In cineangiograms from 60 consecutive patients with chronic coronary occlusions morphological details in at least two projections were evaluated in relation to the rate of success and the estimated age of occlusion. Morphological features associated with a higher rate of success (type A) were a clearcut proximal stump, absence of side branches at the site of occlusion, absence of bridging collaterals, and only slight filling of the distal part of the vessel. Features associated with a low success rate (type B) were absence of proximal stump, side branches at the site of occlusion, bridging collaterals, and rapid high-contrast filling of the distal part of the vessel. 48/60 (80%) of occlusions could be classified as type A or type B. The success rate was 17/21 (81%) in type A versus 5/27 (18.5%) in type B (P < 0.0002). The estimated age of type B occlusions was higher than that of type A medians 8 and 4 months (P < 0.002). Thus in chronic coronary occlusions the likelihood of successful reopening can be judged in many patients from morphological features. Images Figure 1 Figure 2 PMID:9155755

  13. Navigating a guide wire through total occlusions: clinical experience

    NASA Astrophysics Data System (ADS)

    Neet, John M.; Winston, Thomas R.; Hedrick, Allan D.; Koolen, Jaques J.; Bonnier, Hans

    2000-05-01

    One of the last remaining frontiers in angioplasty interventions is successfully recanalizing arteries containing total occlusions. The primary limiting condition is the inability to pass a guide wire safely across the total occlusion to facilitate therapeutic interventions. The operator has to perform the intervention without the assistance of x-ray imaging to define the vessel's path since the contrast media flow is blocked by the occlusion. To overcome this limitation, a guide wire system has been developed that transmits low coherence near-infrared light through an optical fiber internal to the guide wire and illuminates the tissue adjacent the distal end. Differences in the scattering of near-infrared light by the normal arterial wall and occluding tissues are detected by optical coherence reflectometry (OCR) techniques. Through a real-time monitoring system and display, the physician is warned if the guide wire approaches the normal arterial wall, allowing the guide wire to be redirected to prevent perforating the vessel. The system has been used in clinical coronary angioplasty cases demonstrating the ability to cross 10 out of 11 total occlusions without any perforations or dissections. The OCR guide wire system has demonstrated clinical potential and will require additional testing for clinical efficacy claims.

  14. Infarct size and regional perfusion following coronary occlusion in the chronically sympathectomized canine ventricle 

    E-print Network

    Beck, Linda Yvonne

    1978-01-01

    INFARCT SIZE AND REGIONAL PERFUSION FOLLOWING CORONARY OCCLUSION IN THE CHRONICALLY SYMPATHECTOMIZED CANINE VENTRICLE A Thesis by LINDA YVONNE BECK Submitted to the Graduate College of Texas A&M University in partial fulfillment... of the requirement for the degree of MASTER OF SCIENCE May 1978 Major Sub)set: Biology INFARCT SIZE AND REGIONAL PERFUSION FOLLOWING CORONARY OCCLUSION IN THE CHRONICALLY SYMPATHECTOMIZED CANINE VENTRICLE A Thesis by LINDA YVONNE BECK Approved as to style...

  15. Survival with Total Occlusion of Left Main Coronary Artery

    PubMed Central

    Choh, Joong H.; Wang, Timothy; Golbus, Glenn A.; Leskovac, Thomas M.; Nazarian, Arthur; Ihm, H. Jae; Khazei, A. Hassan

    1984-01-01

    Complete occlusion of the left main coronary artery is considered to be a terminal event in most cases. We describe two patients with this lesion who underwent successful coronary bypass surgery with complete relief of symptoms and long-term survival. The angiographic findings and clinical management of the two patients are discussed. * Images PMID:15227097

  16. Chronic innominate artery occlusion with hyperacute intracranial thromboembolism: Revascularization with simultaneous local thromboaspiration and mechanical thrombectomy

    PubMed Central

    Gordhan, Ajeet; Vanle, Jesse

    2015-01-01

    Chronic innominate artery occlusion with acute right internal carotid terminus thromboembolism and successful revascularization using simultaneous local thromboaspiration and mechanical thrombectomy has not been previously described. A 51-year-old male presented with transient left hemiparesis. A CT angiogram of the head and neck demonstrated chronic occlusion of the right innominate artery with no intracranial thromboembolism. More profound symptoms recurred twelve hours after admission. A diagnostic catheter-based angiogram confirmed occlusion of the innominate artery and identified hyper-acute right carotid terminus thromboembolism. Angioplasty of the innominate artery was followed by simultaneous mechanical and aspiration thrombectomy of the right internal carotid artery terminus. Combination local thromboaspiration and mechanical thrombectomy was shown in this case to be effective in achieving a favorable clinical outcome. PMID:25926931

  17. Stent Recanalization of Chronic Portal Vein Occlusion in a Child

    SciTech Connect

    Cwikiel, Wojciech [Department of Diagnostic Radiology, University Hospital, S-221 85 Lund (Sweden); Solvig, Jan [Department of Diagnostic Radiology, University Hospital, Skejby, DK-8200 Aarhus (Denmark); Schroder, Henrik [Department of Pediatric Medicine, University Hospital, Skejby, DK-8200 Aarhus (Denmark)

    2000-07-15

    An 8-year-old boy with a 21/2 year history of portal hypertension and repeated bleedings from esophageal varices, was referred for treatment. The 3.5-cm-long occlusion of the portal vein was passed and the channel created was stabilized with a balloon-expandable stent; a portosystemic stent-shunt was also created. The portosystemic shunt closed spontaneously within 1 month, while the recanalized segment of the portal vein remained open. The pressure gradient between the intrahepatic and extrahepatic portal vein branches dropped from 17 mmHg to 0 mmHg. The pressure in the portal vein dropped from 30 mmHg to 17 mmHg and the bleedings stopped. The next dilation of the stent was performed 12 months later due to an increased pressure gradient; the gastroesophageal varices disappeared completely. Further dilation of the stent was planned after 2, 4, and 6 years.

  18. Surgical femorocaval bypass for treating chronic iliac vein occlusion: a case report

    PubMed Central

    Hao, Qingzhi; Ma, Ruiping; Kang, Yanmeng; Chen, Bainan; Wang, Bin; Zheng, Yuehong

    2014-01-01

    Chronic inferior vena cava and iliac vein occlusion, caused by long-term of deep venous thrombosis, will lead to swelling of the limbs, venous claudication and intractable ulcer. However, conservative treatment is often ineffective for vein occlusion. With the development of interventional techniques, endovascular therapy has become the first choice for the treatment of vein occlusion with higher success rate and lower trauma. However, for cases those fail endovascular therapy or for segmental veno-occlusive diseases with low long-term patency rate, venous bypass might be the only option. And, design of anastomotic stoma and orificium fistulae design is crucial to the success of operation. A case of long term deep venous thrombosis patient with occlusion in bilateral iliac vein and distal inferior vena cava was admitted and treated with interventional therapy. Unfortunately, this method failed. Then, we selected reasonable anastomotic stoma and orificium fistulae and performed femorocaval bypass. The 12 month follow-up results showed that the swelling was successively relieved and the ulcer healed. This indicated that rational anastomotic stoma and orificium fistulae could guarantee the exact clinical efficacy of venous bypass and higher long-term patency rate. PMID:25419436

  19. Total UK multi-centre experience with a novel arterial occlusion device (Duct Occlud pfm)

    Microsoft Academic Search

    A. Tometzki; K. Chan; J. De Giovanni; A. Houston; R. Martin; D. Redel; A. Redington; M. Rigby; J. Wright; N. Wilson

    1996-01-01

    OBJECTIVE: To report the total UK multicentre experience of a novel arterial occlusion device (Duct Occlud pfm). DESIGN: Descriptive study of selected non-randomised paediatric patients with a variety of aortopulmonary connections. SETTING: Five UK tertiary referral centres for congenital heart disease. PATIENTS AND METHODS: Between March 1994 and February 1995, 57 children aged 2 weeks to 14 years (median 50

  20. Operative results and outcome of twenty-four totally laparoscopic vascular procedures for aortoiliac occlusive disease

    Microsoft Academic Search

    Letterio Barbera; Achim Mumme; Senkal Metin; Volker Zumtobel; Matthias Kemen

    1998-01-01

    Purpose: The study objective was to apply laparoscopic techniques to conventional bypass procedures for aortoiliac occlusive disease. Methods: From October 1995 to August 1997, we performed seven iliofemoral (IFB), five unilateral aortofemoral (UAFB), and 11 aortobifemoral (AFB) bypass procedures and one aortic endarterectomy (TEA) totally laparoscopic. A transabdominal approach with pneumoperitoneum was preferred, and only laparoscopic vascular instruments were used.

  1. Primary Stenting Versus Balloon Angioplasty in Occluded Coronary Arteries The Total Occlusion Study of Canada (TOSCA)

    Microsoft Academic Search

    Christopher E. Buller; Vladimir Dzavik; Ronald G. Carere; G. B. John Mancini; Gerald Barbeau; Charles Lazzam; Todd J. Anderson; Merril L. Knudtson; Jean-Francois Marquis; Takahiko Suzuki; Eric A. Cohen; Rebecca S. Fox; Koon K. Teo

    Background—Balloon angioplasty (PTCA) of occluded coronary arteries is limited by high rates of restenosis and reocclusion. Although stenting improves results in anatomically simple occlusions, its effect on patency and clinical outcome in a broadly selected population with occluded coronary arteries is unknown. Methods and Results—Eighteen centers randomized 410 patients with nonacute native coronary occlusions to PTCA or primary stenting with

  2. Percutaneous Intraluminal Recanalization of Long, Chronic Superficial Femoral and Popliteal Occlusions Using the Frontrunner XP CTO Device: A Single-Center Experience

    SciTech Connect

    Charalambous, Nikolas, E-mail: charalambous@rad.uni-kiel.de; Schaefer, Philipp J.; Trentmann, Jens; Huemme, Tim. H.; Stoehring, Christine [University Hospital of Schleswig-Holstein, Department of Diagnostic Radiology (Germany); Mueller-Huelsbeck, Stefan [Academic Hospitals Flensburg, Department of Radiology (Germany); Heller, Martin; Jahnke, Thomas [University Hospital of Schleswig-Holstein, Department of Diagnostic Radiology (Germany)

    2010-02-15

    The purpose of this study was to examine the safety and efficacy of the Frontrunner XP CTO (chronic total occlusion) Catheter (Cordis) for recanalization of long femoropopliteal artery occlusions. A Frontrunner catheter was used to treat 26 CTOs in SFA after guidewire failure (68.3 {+-} 8.8 years). Sixty-seven percent of patients had severe claudication. Critical lower limb ischemia with rest pain or minor tissue loss was present in three and eight patients, respectively. All the lesions were considered complex (TASC B, C, and D); 68% of the lesions were heavily calcified. The mean lesion length was 17.6 cm (range, 10-42 cm). The initial attempt to cross the occlusion with the CTO guidewire V18 was unsuccessful in 26 of 76 limbs (34.26%). A secondary attempt using the Frontrunner catheter (crossover approach, 27%; antegrade, 73%) performed in all 26 failed cases was successful in 17 limbs (65.38%), increasing the technical success rate to 88.12%. The main reasons for failure with the Frontrunner were inability to cross the lesion due to heavy calcification (six of nine) and inability to re-enter the true lumen after subintimal passage of the occluded segment (three of nine). The mean fluoroscopy time was 22.9 min. Minor complications included one distal extension of the dissection with involvement of the first popliteal segment and one perforation in the occluded segment. No major complications were seen. In conclusion, recanalization with the Frontrunner CTO catheter is a simple and safe method with a high technical success rate in the endovascular treatment of long superficial femoral artery occlusions and should be an alternative method after guidewire failure.

  3. Trans-venous occlusion of incompetent pelvic veins for chronic pelvic pain in women: a systematic review.

    PubMed

    Hansrani, Vivak; Abbas, Abeera; Bhandari, Sahil; Caress, Ann-Louise; Seif, Mourad; McCollum, Charles N

    2015-02-01

    Chronic pelvic pain (CPP) affects 24% of women worldwide; the cause cannot be identified in 40% despite invasive investigations. Dilated, refluxing pelvic veins may be a cause of CPP and treatment by trans-venous occlusion is increasingly performed when gynecological causes are excluded, but is it effective? A systematic review of the literature published between 1966 and July 2014 was conducted. Two authors independently reviewed potential studies according to a set of eligibility criteria, with a third assessor available as an arbiter. Thirteen studies including 866 women undergoing trans-venous occlusion of pelvic veins for CPP were identified (Level of evidence: one study grade 2b, 12 studies grade four). Statistical significant improvements in pelvic pain were reported in nine of the 13 studies. Technical success was reported in 865 of 866 (99.8%) with low complication rates: coil migration in 14 women (1.6%), abdominal pain in ten women (1.2%) and vein perforation in five (0.6%). In a study on varicose veins of the legs, recurrence was seen in 13% of 179 women 5-years following coil embolization. Subjective improvements in pain were seen in all 13 studies after treatment by trans-venous occlusion. All 13 studies were of poor methodological quality. Complication rates were low and no fatalities occurred. Well-designed studies are essential to determine whether pelvic vein incompetence (PVI) is associated with CPP, and to explore whether trans-venous occlusion of PVI improves quality of life for these women. PMID:25590499

  4. A Case of Takayasu’s Arteritis with Total Occlusion of the Abdominal Aorta Treated Only with Oral Medication for More Than 40 Years

    PubMed Central

    Fujii, Jun; Seko, Yoshinori

    2015-01-01

    Takayasu’s arteritis affects most commonly young women, often causing stenotic and occasionally dilated lesions of the medium-to-large-sized arteries with an acute inflammatory signs and symptoms. Here, we report a rare case of Takayasu’s arteritis with total occlusion of the abdominal aorta, which was successfully treated with medication alone and asymptomatic over 40 years. Magnetic resonance imaging revealed total occlusion of the abdominal aorta and stenosis of the right carotid artery. This is the first report of a very rare case of Takayasu’s arteritis, in which medical treatment only was successful against total occlusion of the abdominal aorta.

  5. [Therapeutic pancreatic duct occlusion in chronic pancreatitis: clinical, exocrine and endocrine consequences in a 12 month follow-up study].

    PubMed

    Schneider, M U; Lux, G; Gebhardt, C; Meister, R; Pichl, J; Heptner, G; Knorr, H; Rödle, T; Domschke, S; Domschke, W

    1985-01-01

    Therapeutic pancreatic duct occlusion (PDO) is applied to preserve endocrine pancreatic function by atrophizing and thus eliminating chronically inflamed exocrine pancreatic parenchyma. So far, efficient and lasting elimination of exocrine parenchyma is brought about only by intraoperative PDO upon partial duodenopancreatectomy. While partial duodenopancreatectomy itself reduces endocrine pancreatic function by about 40%, intraoperative PDO does not further impair endocrine function. Endocrine function is not affected at all by endoscopic PDO, which has to be improved, however, concerning its eliminatory effect on exocrine pancreatic parenchyma. PMID:3887075

  6. da Vinci's Window Facilitates Drawings of Total and Partial Occlusion in Young Children.

    ERIC Educational Resources Information Center

    Radkey, Andrea L.; Enns, James T.

    1987-01-01

    Study separated two components of drawing: perspective taking and graphic skill. Results suggest that failures of young children to draw occlusion have less to do with graphic skill than was previously thought. Results further suggest that young children have a more general difficulty selecting one perspective and maintaining it over time.…

  7. Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat

    Microsoft Academic Search

    Daniel Lavinsky; Nice Sarmento Arterni; Matilde Achaval; Carlos Alexandre Netto

    2006-01-01

    Background  Ocular ischemic syndrome is a devastating eye disease caused by severe carotid artery stenosis. The reduction of blood flow\\u000a produced by bilateral common carotid artery occlusion (BCCAO) of rats for 7 days induces events related to gliosis with no\\u000a evident histological damage. However, retinal degeneration and cellular death occur after 90 days of BCCAO. Our purpose has\\u000a been to investigate

  8. Lung Reperfusion Injury after Chronic or Acute Unilateral Pulmonary Artery Occlusion

    Microsoft Academic Search

    ELIE FADEL; GUY-MICHEL MAZMANIAN; ALAIN CHAPELIER; BRUNO BAUDET; HÉLÈNE DETRUIT; JEAN-MARIE LIBERT; MYRIAM WARTSKI; PHILIPPE HERVE; PHILIPPE DARTEVELLE

    Because the lungs receive their blood supply from both the pulmonary and bronchial systems, chronic pulmonary artery obstruction does not necessarily result in severe ischemia. Ischemia-reper- fusion (IR) lung injury may therefore be attenuated after long-term pulmonary artery obstruction. To test this hypothesis, isolated left lungs of pigs were reperfused two days (acute IR group) or 5 wk (chronic IR

  9. Protective effect of total flavones from Elsholtzia blanda (TFEB) on myocardial ischemia induced by coronary occlusion in canines.

    PubMed

    Haiyun, Ling; Yijia, Lou; Honggang, Lou; Honghai, Wu

    2004-09-01

    This study was undertaken to determine the effect of total flavones from Elsholtzia blanda (Benth.) Benth. (TFEB), a traditional Chinese medicine, on myocardial ischemia induced by coronary occlusion in Beagle dogs. Infarct size of left ventricle, serum activity of creatine kinase-MB (CK-MB) and malondialdehyde (MDA), hemorrheologic variables and homodynamic parameters including mean arterial pressure (MAP), coronary blood flow (CBF), coronary vascular resistance (CVR), end-diastolic pressure of left ventricle (LVEDP), rate of rise and decline of left ventricular pressure (+/-dp/dtmax) were measured in this study. Administration with TFEB produced a dose-dependent reduction in infarct size. TFEB 100 mg/kg exerted notable inhibition in the elevation of serum CK-MB and MDA activity. TFEB significantly reduced MAP and CVR. The decrease in CBF also tended to be smaller in treated dogs. TFEB improved the recovery of myocardial function by depressing the degree of reduction in +/-dp/dtmax and LVEDP. TFEB also showed a capacity to resist ischemic damage through lowering blood viscosity. The results indicated that TFEB kept heart from ischemic damage due to coronary occlusion in Beagle dogs. PMID:15261969

  10. Chronic renal ischemia in humans: can cell therapy repair the kidney in occlusive renovascular disease?

    PubMed

    Saad, Ahmed; Herrmann, Sandra M; Textor, Stephen C

    2015-05-01

    Occlusive renovascular disease caused by atherosclerotic renal artery stenosis (ARAS) elicits complex biological responses that eventually lead to loss of kidney function. Recent studies indicate a complex interplay of oxidative stress, endothelial dysfunction, and activation of fibrogenic and inflammatory cytokines as a result of atherosclerosis, hypoxia, and renal hypoperfusion in this disorder. Human studies emphasize the limits of the kidney adaptation to reduced blood flow, eventually leading to renal hypoxia with activation of inflammatory and fibrogenic pathways. Several randomized prospective clinical trials show that stent revascularization alone in patients with atherosclerotic renal artery stenosis provides little additional benefit to medical therapy once these processes have developed and solidified. Experimental data now support developing adjunctive cell-based measures to support angiogenesis and anti-inflammatory renal repair mechanisms. These data encourage the study of endothelial progenitor cells and/or mesenchymal stem/stromal cells for the repair of damaged kidney tissue. PMID:25933818

  11. Diagnostic value of color doppler ultrasonography in detecting stenosis and occlusion of central veins in patients with chronic kidney disease.

    PubMed

    Rad, Masoud Pezeshki; Kazemzadeh, Gholam Hosain; Ziaee, Masood; Azarkar, Ghodsieh

    2015-03-01

    Venography is an invasive diagnostic test that uses contrast material that provides a picture of the condition of the veins. But, complications, including adverse effects on the kidney, do occur. On the other hand, with the current technological development, application of ultrasound in the diagnosis of obstructive diseases of the veins is gaining popularity, being non-invasive, easy to perform and cost-effective. The aim of this study was to evaluate the diagnostic value of Doppler sonography in the diagnosis of central vein stenosis. In this descriptive-analytical study, 41 hemodialysis patients who had been referred for 50 upper limb venographies to the radiology department of Imam Reza (AS) were included. Patients with chronic kidney disease with a history of catheterization of the vein, jugular or subclavian, and who had established fistulas or synthetic vascular grafts were targeted. Central venous ultrasound was performed on both sides to evaluate stenosis or occlusion. Venography was performed by the radiologist the next day or the day before hemodialysis. Data on demographic characteristics, findings of clinical examination and findings of ultrasound as well as venography were recorded by using the SPSS software, Chi-square test and Spearman correlation, and Kappa agreement was calculated for sensitivity, specificity and predictive values. Twenty-three (56%) patients were male subjects and 18 patients (44%) were female. Twenty-three (56%) patients of the study population were aged <60 years and 18 (43/9%) patients were aged >60 years. The overall sensitivity, specificity and positive predictive value and negative predictive value of Doppler sonography in the proximal veins in hemodialysis patients compared with venography were, respectively, 80.9%, 79.3%, 73.9% and 85.1%. Color Doppler sonography, as a non-invasive method, could be a good alternative for venography in the assessment of the upper limb with central vein stenosis and occlusion. PMID:25758875

  12. PON1 status evaluation in patients with chronic arterial occlusion of lower limbs due to atherosclerosis obliterans

    PubMed Central

    Iskra, Maria; Majewski, Wac?aw; Budzy?-Napiera?a, Magdalena; Gryszczy?ska, Bogna; Strzy?ewski, Krzysztof; Kasprzak, Jakub

    2014-01-01

    Introduction Human paraoxonase (PON1) is a calcium-dependent enzyme physically associated with HDL, and it is believed to contribute to the atheroprotective effect of HDL. The aim of the study was to evaluate PON1 status in patients with atherosclerosis obliterans as an effect of ischemia regarding its activity and phenotype distribution. Material and methods The study group consisted of patients with chronic arterial occlusion of the lower limbs due to atherosclerosis obliterans (AO). The patients were divided into two groups according to the degree of ischemia: moderate (MI), and critical (CI). The ratio of the hydrolysis of salt-stimulated PON1 activity to the hydrolysis of phenylacetate was used to assign individuals to one of three possible phenotypes (low activity – A, medium activity – AB, high activity – B). It was observed that PON1 arylesterase activity was affected by ischemia of the lower limbs depending on its degree. Results The odds ratio and the relative risk analysis showed that the patients with moderate ischemia are much more often characterized by phenotype A than by phenotype B. The low activity phenotype A occurs over twice as often in patients with chronic ischemia of the lower limbs as in individuals from the control group (OR = 2.125; 1.96 to 3.776, p = 0.0143). Conclusions This study presents the low activity phenotype A in relation to the risk of ischemia of the lower limbs due to atherosclerosis and shows the potentially important role of PON1 in conclusion of the process leading to intensification of ischemia degree. PMID:25624845

  13. Post-occlusion administration of sodium butyrate attenuates cognitive impairment in a rat model of chronic cerebral hypoperfusion.

    PubMed

    Liu, Hui; Zhang, Jun-Jian; Li, Xiong; Yang, Ying; Xie, Xiao-Feng; Hu, Ke

    2015-08-01

    Chronic cerebral hypoperfusion (CCH) has been commonly associated with Alzheimer's disease and other types of dementia, but therapies that can improve cerebral blood flow displayed little effect on impaired cognition. Epigenetic intervention with histone deacetylase inhibitors, such as sodium butyrate (SB), on the other hand has been shown to improve cognition in several animal models of dementia. To investigate the effect of SB on cognitive impairment induced by CCH in rats, adult male SD rats were given intraperitoneal injections of SB at a daily dose of 840mg/kg for 4weeks, from the 29th day after permanent occlusion of bilateral common carotid arteries (2VO). Learning and memory were assessed by Morris water maze and novel object recognition. Following behavioral tests, western blotting of histone acetylation, of transcription factors, of neuronal/synaptic proteins, were performed using rat hippocampus and cortex. The data showed that SB treatment alleviated hippocampal dependent spatial learning disability in 2VO rats, and altered HDAC1/2 mRNA level, histone H4 acetylation and Nrf2 transcriptional activation in rat hippocampus. Accordingly, cognition-protective effect of SB appeared to be partially mediated by enhancing histone acetylation and hence by facilitating the transcription of Nrf2 downstream genes in the hippocampus. Thus, SB might be considered for putative treatment for CCH-related cognitive impairment. PMID:26013850

  14. The Impact of Chronic Intrauterine Inflammation on the Physiologic and Neurodevelopmental Consequences of Intermittent Umbilical Cord Occlusion in Fetal Sheep

    PubMed Central

    Nitsos, Ilias; Newnham, John P.; Rees, Sandra M.; Harding, Richard; Moss, Timothy J. M.

    2014-01-01

    Objective: To determine the effect of intrauterine inflammation on fetal responses to umbilical cord occlusion (UCO). Study Design: In pregnant sheep, lipopolysaccharide (LPS) or saline (SAL) was infused intra-amniotically for 4 weeks from 80 days of gestation (d). At 110 d, fetuses were instrumented for UCOs (5 × 2-minutes, 30-minute intervals: LPS + UCO, n = 6; SAL + UCO, n = 8) or no UCO (sham, n = 6) on 117 and 118 d. Tissues were collected at 126 d. Results: Fetal physiological responses to UCO were similar between LPS + UCO and SAL + UCO. Histologic chorioamnionitis and increased amniotic fluid interleukin 8 (IL-8) were observed in LPS + UCO pregnancies (versus SAL + UCO, P < .05). CNPase-positive oligodendrocyte number in the cerebral white matter was lower in LPS + UCO and SAL + UCO than sham (P < .05); there was no effect on astrocytes or activated microglia/macrophages. Two of the SAL + UCO fetuses had white matter lesions; none were observed in LPS + UCO or sham. Conclusion: Chronic pre-existing intrauterine inflammation did not exacerbate fetal brain injury induced by intermittent UCO. PMID:21421894

  15. Sites of Peripheral Artery Occlusive Disease as a Predictor for All-Cause and Cardiovascular Mortality in Chronic Hemodialysis

    PubMed Central

    Tsai, Ming-Hsien; Liou, Hung-Hsiang; Leu, Jyh-Gang; Yen, Ming-Fang; Chen, Hsiu-Hsi

    2015-01-01

    Background The ankle—brachial blood pressure (BP) index (ABI) not only indicates the presence of peripheral artery occlusive disease (PAOD) but predicts mortality in patients undergoing hemodialysis (HD). However, whether the site of PAOD can provide additional contribution to predicting mortality have not been investigated yet. Our primary objective was to determine the associations between the site of PAOD and all-cause and cardiovascular mortality in chronic HD (CHD) patients. Methods A retrospective cohort study was conducted to evaluate 444 Taiwanese CHD patients between December 2006 and June 2013. The site of PAOD together with other explanatory variables such as demographic data, body mass index, a history of cardiovascular diseases, HD vintage, biochemical data, and cardiothoracic ratio (CTR) were assessed by the Cox proportional hazards regression model. Results The frequency of PAOD was 14.6% in both legs, 4.9% in the right side only, and 5.1% in the left side only. During the study period, 127 all-cause and 93 cardiovascular deaths occurred. PAOD site was found to have significant predictive power for all-cause mortality with the order of 3.04 (95% CI: 1.56–5.90) hazard ratio on the right side, 2.48 (95% CI: 1.27–4.82) on the left side, and 4.11 (95% CI: 2.76–6.13) on both sides. The corresponding figures for cardiovascular mortality were 3.81 (95% CI: 1.87–7.76) on the right side, 2.76 (95% CI: 1.30–5.82) on the left side, and 3.95 (95% CI: 2.45–6.36) on both sides. After adjustment for other explanatory variables, only right-sided PAOD still remained to have significant predictive power for all-cause and cardiovascular mortality and bilateral PAOD kept the significant association with all-cause mortality. Conclusions The site of PAOD revealed various predictive powers for all-cause and cardiovascular mortality in CHD patients and only right-sided PAOD remained an independent predictor for both types of mortality making allowance for relevant confounding factors. PMID:26035831

  16. Perfusion-CT compared to H215O/O15O PET in Patients with Chronic Cervical Carotid Artery Occlusion

    PubMed Central

    Kamath, Amita; Smith, Wade S.; Powers, William J.; Cianfoni, Alessandro; Chien, Jeffrey D.; Videen, Tom; Lawton, Michael T.; Finley, Bruce; Dillon, William P.; Wintermark, Max

    2008-01-01

    Background and Purpose As part of the Carotid Occlusion Surgery Study (COSS), patients with chronic cervical carotid artery occlusive disease are selected for extracranial-intracranial bypass surgery based on the results of 15O2/H215O PET imaging. The purpose of this study was to compare the results of Perfusion-CT (PCT) with those of 15O2/H215O PET in a subset of COSS patients. Materials & Methods Six patients enrolled in COSS underwent a standard-of-care PCT in addition to the 15O2/H215O PET study used for determining study eligibility. PCT and PET studies were coregistered and then processed separately by different radiologists. Relative measurement of cerebral blood flow (CBF) and oxygen extraction fraction (OEF) without arterial sampling were calculated from two PET scans, one for O15O inhalation and one for H215O injection. PCT datasets were processed using different arterial input functions (AIF), on the side of the carotid occlusion (“ischemic” inputs) and on the contralateral side (“nonischemic” inputs). The same sets of symmetric regions of interests (anterior, middle and posterior cerebral artery distribution) were drawn on both hemispheres on matching slices from both imaging modalities (PCT and PET). Relative PCT and PET CBF values (“ischemic” side divided by “nonischemic” side) were compared using linear regression model, in order to determine the most appropriate arterial input function for PCT. As a secondary analysis, PCT values of relative CBF, cerebral blood volume (CBV) and mean transit time (MTT) using the most accurate arterial input function were evaluated for linear regression with respect to relative PET OEF values, which are used for determining study eligibility in COSS. Results The most accurate PCT relative CBF maps with respect to the gold standard PET CBF, were obtained when CBF values for each arterial territory are calculated using a dedicated AIF for each territory (ACA AIF for ACA territory, right MCA AIF for right MCA territory, left MCA AIF for left MCA territory) (R2 = 0.796, p < 0.001). PCT MTT is the parameter that showed the best correlation with the count-based PET OEF ratios (slope = 0.124, intercept = 0.676, R2 = 0.590, p < 0.001). Conclusion PCT relative CBF compares favorably to PET relative CBF in patients with chronic carotid occlusion when processed using a dedicated AIF for each territory. The PCT MTT parameter correlated best with PET relative OEF. Prospective investigations are needed to assess whether PCT can be used as an alternative to PET OEF to identify patients with recently symptomatic carotid artery occlusion who are at high risk for subsequent stroke. PMID:18509627

  17. The cognitive and histopathological effects of chronic 4-vessel occlusion in rats depend on the set of vessels occluded and the age of the animals.

    PubMed

    Barros, Carla Aparecida; Ekuni, Roberta; Moro, Marco Aurélio; Pereira, Francine Martins; Dos Santos Pereira, Marli Aparecida; Milani, Humberto

    2009-02-11

    Continuing previous efforts to develop the 4-vessel occlusion (4-VO) model of chronic cerebral hypoperfusion (CCH), here we evaluated whether permanent, stepwise 4-VO causes both learning deficits, hippocampal neurodegeneration and retinal lesion in young, middle-aged or aged rats. Chronic 4-VO was induced by ligation of different sets of vessels, i.e., the vertebral arteries (VA) plus common carotid arteries (CCA) (4-VO/CCA model) or the VA plus internal carotid arteries (ICA) (4-VO/ICA model) with a 1-week interstage interval. Forty days after the 4-VO, the rats were tested for spatial learning impairment, and then examined for hypoxic/ischemic damage. Young, 4-VO/CCA rats exhibited cognitive impairment, hippocampal neurodegeneration and retinal lesion (p<0.0001-0.05). After 4-VO/ICA, neither young nor middle-aged rats exhibited any learning deficits, hippocampal or retinal damage. In aged rats, chronic 4-VO/ICA caused a mild learning deficit (p<0.05). A significant effect of training was observed for the old, sham-operated rats (p<0.0001-0.001), but not for the aged 4-VO/ICA rats (p>0.05). On average, hippocampal cell density did not change after 4-VO/ICA in aged rats, but 3 of 10 subjects exhibited reduced pyramidal cell counts in all hippocampal subfields. Retinal morphology appeared to be unaffected in the 4-VO/ICA aged rats. These data suggest that the 4-VO/ICA model, but not the 4-VO/CCA model, is a suitable paradigm to study the behavioral outcome of CCH given the preservation of the retina after 4-VO/ICA. Moreover, the age at which 4-VO/ICA occurs seems to be an important factor for determining the behavioral and neuropathological changes. PMID:19007820

  18. Occlusion Calculator

    PubMed Central

    Hiremath, Anand; Aluckal, Eby

    2015-01-01

    Start with end in mind’ is a popular cliché in orthodontics. This aptly applies to the therapeutic occlusion the orthodontist strives to achieve. Predicting the post treatment occlusion is an essential component of treatment planning. When no extractions or symmetric extractions are done predicting the final occlusion is somewhat easy. Prediction is challenging when we do unconventional and/or asymmetric extractions. To aid this decision Kesling proposed the ‘Kesling Setup’. Though it serves the purpose acceptably; it is time, energy and money consuming. We have developed a model which can help us visualize the final occlusion in matter of seconds. Although this model is primarily intended for orthodontic postgraduate teaching, it can be of considerable use even to a seasoned orthodontist. The regular use of “Orthodontic Calculator” in our department is a testimony to its usefulness. PMID:25738101

  19. [Pain in chronic arterial occlusive disease--the effect of improved macrocirculation on pseudo-radicular irritation].

    PubMed

    Falkenbach, A; Blumenthal, E; Landgraf, H; Bühring, M

    1991-01-01

    In chronic obliterating arteriopathy the maximum walking distance does not correlate well with the ankle arm index of arterial pressure measured by Doppler ultrasound. Beside reduced macrocirculation and microcirculatory maldistribution in skeletal muscle, pseudoradicular irritation was established as a relevant factor for the onset of pain during walking. The present study investigates the influence of the macrocirculation on hyperalgesia at rest in intermittent claudication. In 35 patients with chronic obliterating arteriopathy of the lower limbs (stage II according to Fontaine) the ankle/arm index of arterial pressure and the walking tolerance, as well as the pain at rest on applying pressure to the calf muscles were determined before and 3 weeks after percutaneous transluminar angioplasty (PTA). All 3 parameters improved after dilatation. Improved macrocirculation leads not only to a decreased production and improved clearance of pain-inducing metabolites in muscle tissue, but also--through a decrease of sympathetic stimulation of the muscle--to an elevation of the pain threshold. Apart from the reduction in pain-inducing metabolites, an absence of booster effects on pseudoradicular irritation and the regeneration of sensitive cutaneous afferents with resultant inhibition of reflex pain development are considered as possible factors in the achievement of pain relief following PTA. PMID:1830437

  20. Elevated Serum Total IgE – A Potential Marker for Severe Chronic Urticaria

    Microsoft Academic Search

    Aharon Kessel; Wissam Helou; Ellen Bamberger; Edmond Sabo; David Nusem; Josef Panassof; Elias Toubi

    2010-01-01

    Background: Elevated IgE levels in patients with chronic urticaria have been noted previously, but the significance of these findings has not been appreciated. Objective: To measure the IgE levels in such patients and to examine the relationship between these levels and urticarial severity, autologous serum skin test, anti-thyroid antibodies and duration. Methods: Serum total IgE levels from 203 patients with

  1. Chronic myelocytic leukemia with near-total pulmonary microvascular obstruction by platelets.

    PubMed

    Blachly, R J; Herring, G F; Mansouri, A

    1988-04-01

    We have described a patient with long-standing chronic granulocytic leukemia. Although most patients with this disorder eventually have a picture of acute leukemia (blast crisis), this patient had massive thrombocytosis (platelet count greater than 5.000 x 10(9)/L) without major symptoms, but he died after transfusion of 1 unit of packed red blood cells. At autopsy, he had almost total pulmonary microvascular blockage with platelets. PMID:3162780

  2. Effect of total phenolics from Laggera alata on acute and chronic inflammation models.

    PubMed

    Wu, Yihang; Zhou, Changxin; Song, Liyan; Li, Xiangping; Shi, Shuyun; Mo, Jianxia; Chen, Haiyong; Bai, Hua; Wu, Xiumei; Zhao, Jun; Zhang, Rongping; Hao, Xiaojiang; Sun, Handong; Zhao, Yu

    2006-11-24

    The anti-inflammatory effect of total phenolics from Laggera alata (TPLA) was evaluated with various in vivo models of both acute and chronic inflammations. In the acute inflammation tests, TPLA inhibited significantly xylene-induced mouse ear oedema, carrageenan-induced rat paw oedema and acetic acid-induced mouse vascular permeability. In the carrageenan-induced rat pleurisy model, TPLA significantly suppressed inflammatory exudate and leukocyte migration, reduced the serum levels of lysozyme (LZM) and malondialdehyde (MDA), increased the serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX), and also decreased the contents of total protein, nitric oxide (NO) and prostaglandin E(2) (PGE(2)) in the pleural exudates. In the chronic inflammation experiment, TPLA inhibited significantly cotton pellet-induced rat granuloma. These results indicated that TPLA possesses potent anti-inflammatory activity on acute and chronic inflammation models. Its anti-inflammatory mechanisms are probably associated with the inhibition of prostaglandin formation, the influence on the antioxidant systems, and the suppression of LZM release. Furthermore, the total phenolic content of Laggera alata and its main component type was quantified, and its principle components were isolated and authenticated. Acute toxicity studies revealed that TPLA up to an oral dose of 8.5 g/kg body weight was almost nontoxic in mice. PMID:16814499

  3. Total Pancreatectomy with Islet Autologous Transplantation: The Cure for Chronic Pancreatitis?

    PubMed Central

    Kesseli, Samuel J; Smith, Kerrington A; Gardner, Timothy B

    2015-01-01

    Chronic pancreatitis (CP) is a debilitating disease that leads to varying degrees of pancreatic endocrine and exocrine dysfunction. One of the most difficult symptoms of CP is severe abdominal pain, which is often challenging to control with available analgesics and therapies. In the last decade, total pancreatectomy with autologous islet cell transplantation has emerged as a promising treatment for the refractory pain of CP and is currently performed at approximately a dozen centers in the United States. While total pancreatectomy is not a new procedure, the endocrine function-preserving autologous islet cell isolation and re-implantation have made the prospect of total pancreatectomy more acceptable to patients and clinicians. This review will focus on the current status of total pancreatectomy with autologous islet cell transplant including patient selection, technical considerations, and outcomes. As the procedure is performed at an increasing number of centers, this review will highlight opportunities for quality improvement and outcome optimization. PMID:25630865

  4. Endovascular recanalization of infrapopliteal occlusions in patients with critical limb ischemia

    PubMed Central

    Singh, Gagan D.; Armstrong, Ehrin J.; Yeo, Khung-Keong; Singh, Satinder; Westin, Gregory G.; Pevec, William C.; Dawson, David L.; Laird, John R.

    2014-01-01

    Background Endovascular therapies are increasingly used for treatment of critical limb ischemia (CLI). Infrapopliteal (IP) occlusions are common in CLI, and successful limb salvage may require restoration of arterial flow in the distribution of a chronically occluded vessel. We sought to describe the procedural characteristics and outcomes of patients with IP occlusions who underwent endovascular intervention for treatment of CLI. Methods All patients with IP interventions for treatment of CLI from 2006 to 2012 were included. Angiographic and procedural data were compared between patients who underwent intervention for IP occlusions vs IP stenosis. Restenosis was determined by Doppler ultrasound imaging. Limb salvage was the primary end point of the study. Additional end points included primary patency, primary assisted patency, secondary patency, occlusion crossing success, procedural success, and amputation-free survival. Results A total of 187 patients with CLI underwent interventions for 356 IP lesions, and 77 patients (41%) had interventions for an IP occlusion. Patients with an intervention for IP occlusion were more likely to have zero to one vessel runoff (83% vs 56%; P < .001) compared with interventions for stenosis. Compared with IP stenoses, IP occlusions were longer (118 ± 86 vs 73 ± 67 mm; P < .001) and had a smaller vessel diameter (2.5 ± 0.8 vs 2.7 ± 0.5 mm; P =.02). Wire crossing was achieved in 83% of IP occlusions, and the overall procedural success for IP occlusions was 79%. The overall 1-year limb salvage rate was 84%. Limb salvage was highest in the stenosis group, slightly lower in the successful occlusion group, and lowest in the failed occlusion group (92% vs 75% vs 58%, respectively; P = .02). Unsuccessfully treated IP occlusions were associated with a significantly higher likelihood of major amputation (hazard ratio, 5.79; 95% confidence interval, 1.89–17.7) and major amputation or death (hazard ratio, 2.69; 95% confidence interval, 1.09–6.63). Conclusions Successful endovascular recanalization of IP occlusions can be achieved with guidewire and support catheter techniques in most patients. In patients selected for an endovascular-first approach for IP occlusions in CLI, this strategy can be successfully implemented with favorable rates of limb salvage. PMID:24393279

  5. Endovascular Treatment of Totally Occluded Superior Mesenteric Artery by Retrograde Crossing via the Villemin Arcade

    SciTech Connect

    Ferro, Carlo; Rossi, Umberto G., E-mail: urossi76@hotmail.com; Seitun, Sara; Bovio, Giulio [IRCCS San Martino University Hospital-IST-National Institute for Cancer Research, Department of Radiology and Interventional Radiology (Italy); Fornaro, Rosario [IRCCS San Martino University Hospital-IST-National Institute for Cancer Research, Department of Surgery (Italy)

    2013-06-15

    Chronic mesenteric ischemia (CMI) is a rare disorder that is commonly caused by progressive atherosclerotic stenosis or occlusion of one or more mesenteric arteries. Endovascular treatment for symptomatic CMI represents a viable option, especially in high-operative risk patients. We report a case of acute symptomatic CMI with chronic totally occlusion of the superior mesenteric artery (SMA) associated with significant stenosis of celiac trunk (CT) and inferior mesenteric artery (IMA) that underwent endovascular treatment of all the three mesenteric arteries: stenting of CT and IMA stenosis, and recanalization of the SMA occlusion by retrograde crossing via the Villemin arcade.

  6. Pain catastrophizing as a risk factor for chronic pain after total knee arthroplasty: a systematic review

    PubMed Central

    Burns, Lindsay C; Ritvo, Sarah E; Ferguson, Meaghan K; Clarke, Hance; Seltzer, Ze’ev; Katz, Joel

    2015-01-01

    Background Total knee arthroplasty (TKA) is a common and costly surgical procedure. Despite high success rates, many TKA patients develop chronic pain in the months and years following surgery, constituting a public health burden. Pain catastrophizing is a construct that reflects anxious preoccupation with pain, inability to inhibit pain-related fears, amplification of the significance of pain vis-à-vis health implications, and a sense of helplessness regarding pain. Recent research suggests that it may be an important risk factor for untoward TKA outcomes. To clarify this impact, we systematically reviewed the literature to date on pain catastrophizing as a prospective predictor of chronic pain following TKA. Methods We searched MEDLINE, EMBASE, and PsycINFO databases to identify articles related to pain catastrophizing, TKA, risk models, and chronic pain. We reviewed titles and abstracts to identify original research articles that met our specified inclusion criteria. Included articles were then rated for methodological quality. including methodological quality. Due to heterogeneity in follow-up, analyses, and outcomes reported across studies, a quantitative meta-analysis could not be performed. Results We identified six prospective longitudinal studies with small-to-mid-sized samples that met the inclusion criteria. Despite considerable variability in reported pain outcomes, pain catastrophizing was identified as a significant predictor of chronic pain persisting ?3 months following TKA in five of the studies assessed. Limitations of studies included lack of large-scale data, absence of standardized pain measurements, inadequate multivariate adjustment, such as failure to control for analgesic use and other relevant covariates, and failure to report non-significant parameter estimates. Conclusion This study provides moderate-level evidence for pain catastrophizing as an independent predictor of chronic pain post-TKA. Directions for future research include larger, well-controlled studies with standard pain outcomes, identification of clinically-relevant catastrophizing cut-offs that predict pain outcomes, investigation of other psychosocial risk factors, and assessment of interventions aimed to reduce pain catastrophizing on chronic pain outcomes following TKA surgery. PMID:25609995

  7. Occlusion processing using particle filter and background subtraction algorithms

    NASA Astrophysics Data System (ADS)

    Guo, Tongqing; Rong, Jian; Lu, Kui; Zhong, Xiaochun

    We present an algorithm based on the Particle Filter algorithmand Background Subtraction algorithm. Particle Filter can track target robustly under kinds of noise conditions, and it's robust to partial occlusion.However, it cannot recover from large proportion of occlusion and total occlusion.Background Subtraction algorithmcan detectnew target which emergeon a relatively stable background.The hybrid algorithm can recover fromlarge proportion of occlusion and total occlusion. A new occlusion measurement factor is imported to switchthe Particle Filter algorithm to Background subtraction algorithm when the target is occluded largely or totally, and switch Background subtraction algorithm to the Particle Filter algorithm when the target went out of the occlusion. The experimental results show that the hybrid algorithm was robust to partial and total occlusions.

  8. Widespread sensitization in patients with chronic pain after revision total knee arthroplasty.

    PubMed

    Skou, Soren Thorgaard; Graven-Nielsen, Thomas; Rasmussen, Sten; Simonsen, Ole H; Laursen, Mogens B; Arendt-Nielsen, Lars

    2013-09-01

    Pain and sensitization are major issues in patients with osteoarthritis both before and after total knee arthroplasty (TKA) and revision TKA (re-TKA). The aim of this study was to assess sensitization in patients with and without chronic pain after re-TKAs. Twenty patients with chronic knee pain and 20 patients without pain after re-TKA participated. Spreading of pain was evaluated as the number of pain sites using a region-divided body chart. The pressure pain threshold (PPT) and pressure pain tolerance (PTT) were assessed by cuff algometry at the lower leg. Temporal summation of pain was assessed by recordings of the pain intensity on a visual analog scale (VAS) during repeated cuff pressure stimulations. Conditioning pain modulation (CPM) was recorded by experimental tonic arm pain by cuff pressure stimulation and assessment of PPTs on the knee, leg, and forearm using handheld pressure algometry. Participants with pain after re-TKA compared to participants without pain demonstrated: (1) significantly more pain sites (P=.004), (2) decreased cuff PPTs and PTTs at the lower leg (P<.001), (3) facilitated temporal summation (P<.001), and (4) impaired CPM (P<.001). Additionally, significant correlations between knee pain intensity and cuff PPTs, temporal summation, and CPM and between total duration of knee pain and temporal summation were found (P<.05). This study demonstrated widespread sensitization in patients with pain after re-TKA and highlighted the importance of ongoing nociceptive input for the chronification process. This has important implications for future revisions, and precautions should be taken if patients have widespread sensitization. PMID:23707268

  9. Uncemented total hip arthroplasty in young patients with juvenile chronic arthritis.

    PubMed Central

    Kumar, M. N.; Swann, M.

    1998-01-01

    The hip joint is commonly affected in juvenile chronic arthritis (JCA) and involvement is usually bilateral. It is well established that the involvement of the hip in JCA is the most important reason that the patient will lose independence and mobility. The positive gains, both in terms of hip function and the overall functional capability, of the patients of JCA after hip replacement have been shown by several studies. There have been many reports regarding cemented total hip replacement in young patients with JCA. The short-term results have been excellent, but failure rates were considerably higher with further follow-up. To our knowledge there have been no other reports to date of the results of cementless arthroplasty of the hip in this condition. We reviewed the results of 25 primary uncemented total hip replacements (THR) in 16 patients with JCA. The mean postoperative follow-up time was 4.5 years (range 1-19 years). The clinical results were evaluated using the modified Harris hip score. The functional outcome was assessed by a scoring system described by Witt et al. The most significant long-term problem was acetabular loosening (12%) in our series. Images Figure 1 Figure 2 PMID:9682646

  10. Occlusal scheme in a group of Thais

    PubMed Central

    Mitrirattanakul, Somsak

    2011-01-01

    PURPOSE To study the distribution of various occlusal schemes as well as associated static occlusal relationship among Thais. MATERIALS AND METHODS The subjects' occlusal schemes on the left and right sides were classified as canine protected occlusion, group function, or unclassified according to the definition from Glossary of Prosthodontic Terms (8th edition). In addition, the presence of occlusal interferences during mandibular excursions were recorded. The measurement of the horizontal overlap and vertical overlap was also performed. Chi-square, One-way ANAVA and Mann-Whitney U statistical tests were used with level of significance set at P=.05. RESULTS Total of 104 subjects were included in this study. The ratio for male to female was 1.8 to 1. Average age of the population was 25.01±6.87 years old. The mean vertical overlap and horizontal overlap were 1.94±1.20 and 2.41±1.32 mm respectively. The majority of the populations (68.3%) possessed group function occlusal scheme. For the remaining, 17.3% possess canine protected occlusion and 12.5% possess combination of both occlusal schemes. We also found that occlusal interference was presented in 20.2% of the population. The most common was protrusive interference (57.14%), the second was balancing interference (38.1%) and the third was working interference (4.1%). CONCLUSION Among Thais, the most common occlusal scheme was group function, however there were no significant occlusal factors related to any particular occlusal scheme. PMID:22053243

  11. Plasma and salivary total antioxidant capacity in healthy controls compared with aggressive and chronic periodontitis patients

    PubMed Central

    Baser, Ulku; Gamsiz-Isik, Hikmet; Cifcibasi, Emine; Ademoglu, Evin; Yalcin, Funda

    2015-01-01

    Objectives: To evaluate the plasma and salivary total antioxidant capacity (TAOC) in patients with generalized chronic periodontitis (CP), generalized aggressive periodontitis (AgP), and periodontally healthy controls. Methods: This cross-sectional study includes of 88 individuals seeking dental treatment at the Faculty of Dentistry, Istanbul University, Istanbul, Turkey between January 2011 and March 2012. Fifteen AgP patients were compared with 21 healthy controls (C1), while 36 CP patients were compared with 16 healthy controls (C2). Clinical periodontal measurements were recorded, and plasma and saliva samples were collected. The TAOC of the plasma and saliva samples were determined using a commercially available colorimetric kit. Results: The plasma TAOC of both AgP and CP patients was significantly lower for C1 and C2. The salivary TAOC of CP patients was significantly lower for C2, but there was no significant difference between AgP patients and C1. Conclusion: Our results demonstrate that severe periodontitis may be associated with a lower plasma antioxidant capacity. The reduced antioxidant capacity in patients with severe periodontitis, especially with aggressive forms may be an important contributing factor to severe tissue destruction. PMID:26108592

  12. Ten-Year Experience Using an Articulating Antibiotic Cement Hip Spacer for the Treatment of Chronically Infected Total Hip

    Microsoft Academic Search

    Aaron A. Hofmann; Tyler D. Goldberg; Amie M. Tanner; Thomas M. Cook

    2005-01-01

    Infection is a devastating complication after total-hip arthroplasty. Between June 1991 and December 2001, 42 patients were treated at our center for chronically infected total-hip arthroplasty using a 2-stage articulating antibiotic hip spacer technique. Of the 27 patients available for review, 26 (94%) remain clinically free of infection at an average 76 months (range, 28-148 months) postoperatively. Twenty-two (81%) patients

  13. Tracking Appearances with Occlusions

    Microsoft Academic Search

    Ying Wu; Ting Yu; Gang Hua

    2003-01-01

    Occlusion is a difficult problem for appearance-based target tracking, especially when we need to track multi- ple targets simultaneously and maintain the target identi- ties during tracking. To cope with the occlusion problem explicitly, this paper proposes a dynamic Bayesian network which accommodates an extra hidden process for occlusion and stipulates the conditions on which the image observa- tion likelihood

  14. The effects of long-acting bronchodilators on total mortality in patients with stable chronic obstructive pulmonary disease

    Microsoft Academic Search

    Agnes Kliber; Larry D Lynd; Don D Sin

    2010-01-01

    BACKGROUND: Chronic obstructive pulmonary disease (COPD) is the 4th leading cause of mortality worldwide. Long-acting bronchodilators are considered first line therapies for patients with COPD but their effects on mortality are not well known. We performed a comprehensive systematic review and meta-analysis to evaluate the effects of long-acting bronchodilators on total mortality in stable COPD. METHODS: Using MEDLINE, EMBASE and

  15. A sensitive HPLC method for the quantification of free and total p-cresol in patients with chronic renal failure

    Microsoft Academic Search

    Rita De Smet; Frank David; Patrick Sandra; Jaqueline Van Kaer; Gerrit Lesaffer; Annemieke Dhondt; Norbert Lameire; Raymond Vanholder

    1998-01-01

    Para-cresol (4-methylphenol) is a volatile phenolic compound which is retained in chronic renal failure. Several recent studies suggest that p-cresol interferes with various biochemical and physiological functions at concentrations currently observed in uremia. Only a few methods are available for the determination of p-cresol concentration in serum. In addition, these methods have only been used for the determination of total

  16. Occlusal considerations in periodontics.

    PubMed

    Davies, S J; Gray, R J; Linden, G J; James, J A

    2001-12-01

    Periodontal disease does not directly affect the occluding surfaces of teeth, consequently some may find a section on periodontics a surprising inclusion. Trauma from the occlusion, however, has been linked with periodontal disease for many years. Karolyi published his pioneering paper, in 1901 'Beobachtungen uber Pyorrhoea alveolaris' (occlusal stress and 'alveolar pyorrhoea'). (1) However, despite extensive research over many decades, the role of occlusion in the aetiology and pathogenesis of inflammatory periodontitis is still not completely understood. PMID:11770945

  17. Thermolabile MTHFR genotype and retinal vascular occlusive disease

    Microsoft Academic Search

    M Cahill; M Karabatzaki; C Donoghue; R Meleady; L A Mynett-Johnson; D Mooney; I M Graham; A S Whitehead; D C Shields

    2001-01-01

    BACKGROUNDRaised levels of total plasma homocysteine (tHcy) are associated with an increased risk of retinal vascular occlusive disease. A thermolabile form of a pivotal enzyme in homocysteine metabolism, methylenetetrahydrofolate reductase (MTHFR), has been associated with vascular occlusive disease and raised tHcy levels. The relation between thermolabile MTHFR genotype, tHcy, and retinal vascular occlusive disease has not been determined.METHODSA retrospective case-control

  18. Urea, creatinine, uric acid, and phosphate spaces and their relationship to total body water during chronic hemodialysis

    SciTech Connect

    Ericsson, F.; Odar-Cederloef, I.E.; Eriksson, C.G.; Lindgren, S.; Kjellstrand, C.M.

    1988-07-01

    The authors determined total body water (TBW) with tritium in 11 patients on chronic hemodialysis and compared this space to that estimated by 60% of body weight, and removal spaces of urea, creatinine, uric acid, and phosphate (PO4). The latter spaces were determined by dividing the total amount of substance (measured in total dialysate) by pre- minus post-dialysis concentrations. Body water X 0.6 was more than 10% less than the tritium space, and showed a maximal variation of 10 liters, or 24%. The removal space of urea was 80% of the tritium space, but correlated closely with it. The difference between total body water and urea removal space was variable and dependent on fluid excess (edema) in the patients. Creatinine, uric acid, and phosphate removal spaces were highly variable and not correlated to total body water. The authors suggest that actual measured TBW should be used, rather than estimations using BW X 0.6, for V in K X T/V, where K = clearance, T = duration of dialysis, and V = the removal space of urea. Furthermore, one may need to introduce a correction factor for urea removal space over TBW in the equation to allow better quantification of dialysis in edematous patients and during very fast dialyses.

  19. Current concepts of vascular occlusive disease

    Microsoft Academic Search

    M. K. O’Malley

    1988-01-01

    Summary  It is accepted that vascular smooth muscle cell proliferation is the central event in occlusive vascular disease. Why this\\u000a occurs in the lesion of atherosclerosis is not yet known for certain but it is probably related in some way to chronic minor\\u000a endothelial trauma. Intimai hyperplasia, on the other hand, is related to mechanical trauma of the endothelium.\\u000a \\u000a Both these

  20. Retinal vein occlusion

    MedlinePLUS

    ... complications of retinal vein occlusion may include: Focal laser treatment, if macular edema is present Injections of anti- ... cause glaucoma. This treatment is still being studied. Laser treatment to prevent the growth of new, abnormal blood ...

  1. Acute arterial occlusion - kidney

    MedlinePLUS

    Acute renal arterial thrombosis; Renal artery embolism; Acute renal artery occlusion; Embolism - renal artery ... kidneys need a good blood supply. The main artery to the kidney is called the renal artery. ...

  2. Endovascular Treatment Strategies in Aortoiliac Occlusion

    SciTech Connect

    Ozkan, Ugur, E-mail: radugur@yahoo.com; Oguzkurt, Levent, E-mail: loguzkurt@yahoo.com; Tercan, Fahri, E-mail: ftercan@yahoo.com; Gumus, Burcak, E-mail: burcakgumus73@yahoo.co [Baskent University Faculty of Medicine, Department of Radiology (Turkey)

    2009-05-15

    The aim of this study was to report our experience in endovascular treatment of total aortoiliac occlusion. Five patients who underwent endovascular recanalization procedures including manual aspiration thrombectomy, balloon angioplasty, and stent placement for total aortoiliac occlusion in a 4-year period were reviewed retrospectively. The mean age of patients was 51 years (range, 43 to 58 years). All patients had abdominal aorta and bilateral common iliac artery occlusion with or without external iliac artery occlusion. All patients either had a contraindication to surgery or refused it. Initial technical success was obtained in four of five (80%) patients. Endovascular techniques were successful in four patients who had good distal runoff and short-segment aortoiliac occlusion, but failed in a patient who had the worst distal runoff and long-segment aortoiliac occlusion. We observed two major complications, one of which was bilateral rupture of the common iliac arteries treated with covered stent placement. Another patient had extension of intra-aortic thrombus into the iliac stent after primary stenting. This was successfully treated with manual aspiration thrombectomy. Aortic and iliac stents remained patent during the follow-up period (median, 18 months; range, 3 to 26 months) in four patients. Primary patency rates at 6, 12, and 24 months were all 80%. In conclusion, endovascular treatment can be an alternative for aortoiliac occlusion in selected patients. Short- to midterm follow-up so far is satisfactory. Removal of intra-aortic thrombus with manual aspiration thrombectomy before balloon angioplasty and/or stenting is possible and a good alternative to thrombolysis.

  3. Knuckle technique guided by intravascular ultrasound for in-stent restenosis occlusion treatment

    PubMed Central

    Tasic, Mladen; Jagic, Nikola; Miloradovic, Vladimir; Nikolic, Dusan

    2015-01-01

    One of the rarest lesions is in-stent restenosis chronic total occlusion (CTO). Limited data suggest that the treatment success rate is dependent on the possibility to cross into the lumen of an occluded stent, and the decision about what technique to use varies by operator preference. The knuckle technique is used to create a deliberate dissection plane in various CTO techniques. A guide wire is pushed until a complex loop is formed and advanced through the lesion. In this report we present a case where a knuckle wire guided by intravascular ultrasound control is used to penetrate the distal cap in an in-stent restenosis CTO lesion. PMID:25848374

  4. Tannerella forsythia is associated with increased levels of atherogenic low density lipoprotein and total cholesterol in chronic periodontitis

    PubMed Central

    Perez-Valencia, Aide-Yancelly; Rendon-Osorio, Willer-Leandro

    2015-01-01

    Background Accumulating evidence suggests that acute and chronic infections with periodontopathogens are associated with an increased risk of cardiovascular disease. The objective of this study was to assess whether Tanerella forsythia and Porphyromonas gingivalis are associated with increased levels of atherogenic low-density lipoprotein (LDL), high-density lipoprotein, total cholesterol (TC), triglycerides and body mass index (BMI) in chronic periodontitis patients. Material and Methods Medical history and clinical and radiographic examination were conducted in 80 chronic periodontitis patients and 28 healthy individuals. Fasting blood samples were drawn for the measurement of the parameters of dyslipidemia. Anthropometric measurements such as height in meters and weight in kilograms were recorded. Both periodontitis and control subjects were asked to answer a questionnaire with regard to their socio-demographic and smoking status. The presence of T. forsythia, and P. gingivalis was detected using primers designed to target the respective 16S rRNA gene sequences. Results The occurrence of T. forsythia and P. gingivalis was higher in the group of subjects with periodontitis. Superior levels of triglycerides were observed in chronic periodontitis patients compared to healthy individuals. High levels of TC in periodontitis persons were significantly associated with increased bleeding on probing. Greater mean levels of TC and LDL were shown in the presence of T. forsythia (P<0.05). Likewise, higher proportions of patients with BMI ?25 kg/m2 related with T. forsythia (P<0.05). T. forsythia was a significant discriminating factor in the multivariate linear regression model emerging as significant explanatory of increased levels of TC (?=17,879, 95% CI = 4,357-31,401; p=0.01) and LDL (?=17,162, 95% CI= 4,009-30,316; p=0.01). Conclusions Higher levels of serum total cholesterol and LDL were observed in the occurrence of T. forsythia and the presence of this periodontopathogen may increase the atherogenic potency of low-density lipoprotein that may augment the risk for atherosclerosis in periodontal disease patients. Key words:Periodontitis, dyslipidemia, Tannerella forsythia, cardiovascular disease.

  5. Changes in Coronary Perfusion after Occlusion of Coronary Arteries in Kawasaki Disease

    PubMed Central

    Kwak, Ji Hee; Kang, I-Seok; Huh, June; Lee, Heung-Jae

    2014-01-01

    Purpose Myocardial infarction in children with total occlusion of a coronary artery after Kawasaki disease is rare due to multiple collateral vessels. We aimed to investigate the changes in coronary perfusion associated with coronary artery occlusion after Kawasaki disease. Materials and Methods Eleven patients with coronary artery occlusion after Kawasaki disease were investigated. Serial coronary angiographies after total occlusion of a coronary artery were reviewed and the changes were described in all patients with additive information collected. Results The median age at the occlusion was 5.9 years old. The interval to occlusion was 6.2±6.9 years. Four left anterior descending coronary artery total occlusions and 10 right coronary artery total occlusions were detected. Immediate coronary artery bypass graft for left anterior descending coronary artery total occlusion made right coronary total occlusion occurred in all except one patient and the intervals thereof were 1 year, 1.8 years, and 4 years. Collaterals to the left coronary artery regressed after recanalization, while new collaterals to the right coronary artery developed. In three, collaterals to the right coronary artery decreased without recanalization without clinical signs. Conclusion The right coronary artery should be followed up carefully because of possible occlusion of new onset or changes in collaterals. PMID:24532503

  6. Total vertebrectomy for stabilisation of chronic spinal lumbar luxation in a paraplegic dog without nociception.

    PubMed

    Tertuliano Marinho, P V; Zani, C C; De Biasi, F; Bahr Arias, M V

    2014-10-01

    An adult male crossbred dog was referred with a history of a road traffic accident that took place 1 month earlier. Neurological examination revealed paraplegia with absent nociception in the pelvic limbs. On epaxial palpation, significant curvature of the anatomical axis of the spine between the third and fourth lumbar vertebrae was observed, with the presence of a bone end almost piercing the dog's skin. Survey radiographs of the lumbar spine revealed severe dislocation between L3 and L4 vertebrae. During surgery, the spinal cord was not visible between the dislocated segments. Because of difficulties in reducing the lumbar luxation during surgery, vertebrectomy and vertebral shortening were performed. After alignment between vertebrae L3 and L5, eight cortical orthopaedic screws and bone cement were used for fixation. After 30 days, the dog started to use a wheelchair and was considered by its owner to have a good quality of life with no evidence of pain. To the authors' knowledge, this is the first case of severe luxation treated by total vertebrectomy and spine shortening in a dog. This surgery can be considered as an option in the management of severe spine luxation when the spinal cord is physically transected. PMID:24962201

  7. Estimation of arterial and cardiopulmonary total peripheral resistance baroreflex gain values: validation by chronic arterial baroreceptor denervation.

    PubMed

    Mukkamala, Ramakrishna; Kim, Jong-Kyung; Li, Ying; Sala-Mercado, Javier; Hammond, Robert L; Scislo, Tadeusz J; O'Leary, Donal S

    2006-05-01

    Feedback control of total peripheral resistance (TPR) by the arterial and cardiopulmonary baroreflex systems is an important mechanism for short-term blood pressure regulation. Existing methods for measuring this TPR baroreflex mechanism typically aim to quantify only the gain value of one baroreflex system as it operates in open-loop conditions. As a result, the normal, integrated functioning of the arterial and cardiopulmonary baroreflex control of TPR remains to be fully elucidated. To this end, the laboratory of Mukkamala et al. (Mukkamala R, Toska K, and Cohen RJ. Am J Physiol Heart Circ Physiol 284: H947-H959, 2003) previously proposed a potentially noninvasive technique for estimating the closed-loop (dimensionless) gain values of the arterial TPR baroreflex (GA) and the cardiopulmonary TPR baroreflex (GC) by mathematical analysis of the subtle, beat-to-beat fluctuations in arterial blood pressure, cardiac output, and stroke volume. Here, we review the technique with additional details and describe its experimental evaluation with respect to spontaneous hemodynamic variability measured from seven conscious dogs, before and after chronic arterial baroreceptor denervation. The technique was able to correctly predict the group-average changes in GA and GC that have previously been shown to occur following chronic arterial baroreceptor denervation. That is, reflex control by the arterial TPR baroreflex was virtually abolished (GA = -2.1 +/- 0.6 to 0.3 +/- 0.2; P < 0.05), while reflex control by the cardiopulmonary TPR baroreflex more than doubled (GC = -0.7 +/- 0.4 to -1.8 +/- 0.2; P < 0.05). With further successful experimental testing, the technique may ultimately be employed to advance the basic understanding of TPR baroreflex functioning in both humans and animals in health and disease. PMID:16306216

  8. Presurgical assessment of temporal summation of pain predicts the development of chronic postoperative pain 12 months after total knee replacement.

    PubMed

    Petersen, Kristian Kjær; Arendt-Nielsen, Lars; Simonsen, Ole; Wilder-Smith, Oliver; Laursen, Mogens Berg

    2015-01-01

    Patients with knee osteoarthritis demonstrate decreased pressure pain thresholds (PPTs), facilitated temporal summation (TS) of pain, and decreased conditioned pain modulation (CPM) compared with healthy controls. This study aimed to correlate preoperative PPTs, TS, and CPM with the development of chronic postoperative pain after total knee replacement (TKR) surgery. Knee pain intensity (visual analog scale [VAS]: 0-10), PPTs, TS, and CPM were collected before, 2 months, and 12 months after TKR. Patients were divided into a low-pain (VAS < 3) and a high-pain (VAS ? 3) group based on their VAS 12 months after TKR. The high-pain group (N = 17) had higher pain intensities compared with the low-pain group (N = 61) before surgery (P = 0.009) and 12 months after surgery (P < 0.001). The PPTs of the low-pain groups were normalized for all measurement sites comparing presurgery with 12 months postsurgery (P < 0.05, contralateral arm: P = 0.059), which was not the case for the high-pain group. The low-pain group showed a functional inhibitory CPM preoperatively and 12 months postoperatively (P < 0.05), which was not found in the high-pain group. The high-pain group had higher facilitated TS preoperatively and 12 months postoperatively compared with the low-pain group (P < 0.05). Preoperative TS level correlated to 12-month postoperative VAS (R = 0.240, P = 0.037). Patients who developed moderate-to-severe pain had pronociceptive changes compared with patients who developed mild pain postsurgery. Preoperative TS level correlated with the postoperative pain intensity and may be a preoperative mechanistic predictor for the development of chronic postoperative pain in patients with osteoarthritis after TKR. PMID:25599301

  9. Vena Cava Occlusion: Balloon Design

    Microsoft Academic Search

    J. F. Sturgeon; K. J. Oconnor; R. W. Snyder

    1977-01-01

    Various considerations in the development of a natural rubber balloon for vascular occlusion, particularly vena cava occlusion are summarized. The physical properties of the rubber necessary for occlusion are discussed. Since the balloon must remain inflated for at least 4 to 12 weeks after implantation, the balloon should be impermeable to the inflation medium. A measure of the impermeability incorporated

  10. Curricular Guidelines in Occlusion.

    ERIC Educational Resources Information Center

    Journal of Dental Education, 1983

    1983-01-01

    Curricular guidelines proposed by the American Association of Dental Schools are outlined, including notes on the interrelationship of occlusion content and other disciplines, an overview of the curriculum, preclinical and clinical goals and objectives, prerequisites, a core content outline, sequencing, faculty, and facilities. (MSE)

  11. Acute Total and Chronic Partial Sleep Deprivation: Effects on Neurobehavioral Functions, Waking EEG and Renin-Angiotensin System

    NASA Technical Reports Server (NTRS)

    Dijk, Derk-Jan

    1999-01-01

    Total sleep deprivation leads to decrements in neurobehavioral performance and changes in electroencephalographic (EEG) oscillations as well as the incidence of slow eye movements ad detected in the electro-oculogram (EOG) during wakefulness. Although total sleep deprivation is a powerful tool to investigate the association of EEG/EOG and neurobehavioral decrements, sleep loss during space flight is usual only partial. Furthermore exposure to the microgravity environment leads to changes in sodium and volume homeostasis and associated renal and cardio-endocrine responses. Some of these changes can be induced in head down tilt bedrest studies. We integrate research tools and research projects to enhance the fidelity of the simulated conditions of space flight which are characterized by complexity and mutual interactions. The effectiveness of countermeasures and physiologic mechanisms underlying neurobehavioral changes and renal-cardio endocrine changes are investigated in Project 3 of the Human Performance Team and Project 3 of the Cardiovascular Alterations Team respectively. Although the. specific aims of these two projects are very different, they employ very similar research protocols. Thus, both projects investigate the effects of posture/bedrest and sleep deprivation (total or partial) on outcome measures relevant to their specific aims. The main aim of this enhancement grant is to exploit the similarities in research protocols by including the assessment of outcome variables relevant to the Renal-Cardio project in the research protocol of Project 3 of the Human Performance Team and by including the assessment of outcome variables relevant to the Quantitative EEG and Sleep Deprivation Project in the research protocols of Project 3 of the Cardiovascular Alterations team. In particular we will assess Neurobehavioral Function and Waking EEG in the research protocols of the renal-cardio endocrine project and renin-angiotensin and cardiac function in the research protocol of the Quantitative EEG and Waking Neurobehavioral Function project. This will allow us to investigate two additional specific aims: 1) Test the hypothesis that chronic partial sleep deprivation during a 17 day bed rest experiment results in deterioration of neurobehavioral function during waking and increases in EEG power density in the theta frequencies, especially in frontal areas of the brain, as well as the nonREM- REM cycle dependent modulation of heart-rate variability. 2) Test the hypothesis that acute total sleep deprivation modifies the circadian rhythm of the renin-angiotensin system, changes the acute responsiveness of this system to posture beyond what a microgravity environment alone does and affects the nonREM-REM cycle dependent modulation of heart-rate variability.

  12. Effect of local anaesthetic infiltration on chronic postsurgical pain after total hip and knee replacement: the APEX randomised controlled trials

    PubMed Central

    Wylde, Vikki; Lenguerrand, Erik; Gooberman-Hill, Rachael; Beswick, Andrew D.; Marques, Elsa; Noble, Sian; Horwood, Jeremy; Pyke, Mark; Dieppe, Paul; Blom, Ashley W.

    2015-01-01

    Abstract Total hip replacement (THR) and total knee replacement (TKR) are usually effective at relieving pain; however, 7% to 23% of patients experience chronic postsurgical pain. These trials aimed to investigate the effect of local anaesthetic wound infiltration on pain severity at 12 months after primary THR or TKR for osteoarthritis. Between November 2009 and February 2012, 322 patients listed for THR and 316 listed for TKR were recruited into a single-centre double-blind randomised controlled trial. Participants were randomly assigned (1:1) to receive local anaesthetic infiltration and standard care or standard care alone. Participants and outcomes assessors were masked to group allocation. The primary outcome was pain severity on the WOMAC Pain Scale at 12 months after surgery. Analyses were conducted using intention-to-treat and per-protocol approaches. In the hip trial, patients in the intervention group had significantly less pain at 12 months postoperative than patients in the standard care group (differences in means: 4.74; 95% confidence interval [CI]: 0.95-8.54; P = 0.015), although the difference was not clinically significant. Post hoc analysis found that patients in the intervention group were more likely to have none to moderate pain than severe pain at 12 months than those in the standard care group (odds ratio: 10.19; 95% CI: 2.10-49.55; P = 0.004). In the knee trial, there was no strong evidence that the intervention influenced pain severity at 12 months postoperative (difference in means: 3.83; 95% CI: ?0.83 to 8.49; P = 0.107). In conclusion, routine use of infiltration could be beneficial in improving long-term pain relief for some patients after THR. PMID:25659070

  13. Chronic obstructive pulmonary disease symptom effects of long-term cumulative exposure to ambient levels of total oxidants and nitrogen dioxide in California Seventh-Day Adventist residents

    SciTech Connect

    Euler, G.L.; Abbey, D.E.; Hodgkin, J.E.; Magie, A.R.

    1988-07-01

    To assess the risk of chronic obstructive pulmonary disease symptoms due to long-term exposure to ambient levels of total oxidants and nitrogen dioxide (NO2), symptoms were ascertained using the National Heart, Lung, and Blood Institute (NHLBI) respiratory symptoms questionnaire. A total of 7,445 Seventh-day Adventist (SDA) nonsmokers who were 25 yr of age or older and had resided at least 11 yr in areas of California with high to low photochemical air pollution were included in this study. Cumulative exposures to each pollutant in excess of four thresholds were estimated for each participant, using zip codes for months of residence and interpolated dosages from state air-monitoring stations. Multiple logistic regression analyses were conducted individually and together for pollutants and included eight covariables, including passive smoking. A statistically significant association with chronic symptoms was seen for total oxidants above 10 pphm (196 mcg/m3) (p less than .004, relative risk of 1.20 for 750 hr/yr). Chronic respiratory disease symptoms were not associated with relatively low NO2 exposure levels in this population. When these pollutant exposures were studied with exposures to total suspended particulates (TSP) and sulfur dioxide (SO2), only TSP exposure above 200 mcg/m3 showed statistical significance (p less than .01). Exposure to TSP is either more strongly associated with symptoms of chronic obstructive pulmonary disease than the other measured exposures or is the best single surrogate representing the mix of pollutants present.

  14. Effect of total lymphoid irradiation on functional status in chronic multiple sclerosis: importance of lymphopenia early after treatment--the pros

    Microsoft Academic Search

    C. Devereux; R. Troiano; G. Zito; R. B. Devereux; K. J. Kopecky; R. Friedman; P. C. Dowling; M. P. Hafstein; C. Rohowsky-Kochan; S. D. Cook

    1988-01-01

    To determine whether immunosuppression by total lymphoid irradiation (TLI) slowed deterioration of chronic progressive multiple sclerosis (MS), functional impairment score and blood lymphocyte counts were compared at 6-month intervals through 4 years following treatment of MS patients by either TLI (n = 27) or sham irradiation (n = 21). At each interval, 20 to 30% fewer TLI-treated patients had deteriorated

  15. Journal of Clinical Sleep Medicine Supplement to Vol. 7, No. 5, 2011S19 Neurobehavioral responses to acute total and chronic partial

    E-print Network

    Pennsylvania, University of

    Journal of Clinical Sleep Medicine Supplement to Vol. 7, No. 5, 2011S19 Neurobehavioral responses to acute total and chronic partial sleep deprivation occur in healthy adults and are particularly evident deficits-- such differences are manifested in proportionality between the mean and variance as sleep loss

  16. Brachial artery reconstruction for occlusive disease: A 12-year experience

    Microsoft Academic Search

    Sean P. Roddy; R. Clement Darling; Benjamin B. Chang; Paul B. Kreienberg; Philip S. K. Paty; William E. Lloyd; Dhiraj M. Shah

    2001-01-01

    Objective: Symptomatic arterial disease of the upper extremity is an uncommon problem. In this study, we evaluate our results with brachial artery reconstruction in patients who present with symptomatic atherosclerotic occlusive disease and compare this cohort's demographics with a similar group with lower extremity ischemia. Methods: From 1986 to 1998, all patients presenting for upper extremity revascularization with chronic ischemia

  17. Total diet study on pesticide residues in France: levels in food as consumed and chronic dietary risk to consumers.

    PubMed

    Nougadère, Alexandre; Sirot, Véronique; Kadar, Ali; Fastier, Antony; Truchot, Eric; Vergnet, Claude; Hommet, Frédéric; Baylé, Joëlle; Gros, Philippe; Leblanc, Jean-Charles

    2012-09-15

    Chronic dietary exposure to pesticide residues was assessed for the French population using a total diet study (TDS) to take into account realistic levels in foods as consumed at home (table-ready). Three hundred and twenty-five pesticides and their transformation products, grouped into 283 pesticides according to their residue definition, were sought in 1235 composite samples corresponding to 194 individual food items that cover 90% of the adult and child diet. To make up the composite samples, about 19,000 food products were bought during different seasons from 2007 to 2009 in 36 French cities and prepared according to the food preparation practices recorded in the individual and national consumption survey (INCA2). The results showed that 37% of the samples contained one or more residues. Seventy-three pesticides were detected and 55 quantified at levels ranging from 0.003 to 8.7mg/kg. The most frequently detected pesticides, identified as monitoring priorities in 2006, were the post-harvest insecticides pirimiphos-methyl and chlorpyrifos-methyl-particularly in wheat-based products-together with chlorpyrifos, iprodione, carbendazim and imazalil, mainly in fruit and fruit juices. Dietary intakes were estimated for each subject of INCA2 survey, under two contamination scenarios to handle left-censored data: lower-bound scenario (LB) where undetected results were set to zero, and upper-bound (UB) scenario where undetected results were set to the detection limit. For 90% of the pesticides, exposure levels were below the acceptable daily intake (ADI) under the two scenarios. Under the LB scenario, which tends to underestimate exposure levels, only dimethoate intakes exceeded the ADI for high level consumers of cherry (0.6% of children and 0.4% of adults). This pesticide, authorised in Europe, and its metabolite were detected in both cherries and endives. Under the UB scenario, that overestimates exposure, a chronic risk could not be excluded for nine other pesticides (dithiocarbamates, ethoprophos, carbofuran, diazinon, methamidophos, disulfoton, dieldrin, endrin and heptachlor). For these pesticides, more sensitive analyses of the main food contributors are needed in order to refine exposure assessment. PMID:22595191

  18. Nontraumatic vascular emergencies: imaging and intervention in acute venous occlusion.

    PubMed

    Haage, Patrick; Krings, Timo; Schmitz-Rode, Thomas

    2002-11-01

    Risk factors for acute venous occlusion range from prolonged immobilization to hypercoagulability syndromes, trauma, and malignancy. The aim of this review article is to illustrate the different imaging options for the diagnosis of acute venous occlusion and to assess the value of interventional strategies for venous thrombosis treatment in an emergency setting.First, diagnosis and treatment of the most common form of venous occlusion, at the level of the lower extremities, is presented, followed by pelvic vein and inferior vena cava occlusion, mesenteric venous thrombosis, upper extremity occlusion, acute cerebral vein thrombosis, and finally acute venous occlusion of hemodialysis access.In acute venous occlusion of the lower extremity phlebography is still the reference gold standard. Presently, duplex ultrasound with manual compression is the most sensitive and specific noninvasive test. Limitations of ultrasonography include isolated distal calf vein occlusion, obesity, and patients with lower extremity edema. If sonography is nondiagnostic, venography should be considered. Magnetic resonance venography can differentiate an acute occlusion from chronic thrombus, but because of its high cost and limited availability, it is not yet used for the routine diagnosis of lower extremity venous occlusion only. Regarding interventional treatment, catheter-directed thrombolysis can be applied to dissolve thrombus in charily selected patients with symptomatic occlusion and no contraindications to therapy. Acute occlusion of the pelvic veins and the inferior vena cava, often due to extension from the femoropopliteal system, represents a major risk for pulmonary embolism. Color flow Doppler imaging is often limited owing to obesity and bowel gas. Venography has long been considered the gold standard for identifying proximal venous occlusion. Both CT scanning and MR imaging, however, can even more accurately diagnose acute pelvis vein or inferior vena cava occlusion. MRI is preferred because it is noninvasive, does not require contrast agent, carries no exposure to ionizing radiation, and is highly accurate and reproducible. Apart from catheter-directed thrombolysis, mechanical thrombectomy has proven to be a quick and safe treatment modality by enabling the recanalization of thrombotic occlusions in conjunction with minimal invasiveness and a low bleeding risk. Mechanical thrombectomy devices should only be used in conjunction with a temporary cava filter.Contrast-enhanced CT is at present considered the examination of choice for acute mesenteric vein occlusion which has mortality rates as high as 80%. Patients with proven acute mesenteric venous occlusion and contraindications to surgical therapy and no identified bleeding disposition without looming bowel ischemia or infarction are possible contenders to the less invasive percutaneous approach either by (in)direct thrombolysis or mechanical means. Ultrasonography is the primary imaging modality for the diagnosis of upper extremity thrombosis. Computed tomography and MRI are in addition helpful in diagnosing central chest vein occlusions. The interventionalist is rarely involved in the treatment of this entity. Catheter-directed thrombolysis is known to improve lysis rates. Together with balloon angioplasty good results have been obtained. If stenosis or thrombus remains after thrombolysis and angioplasty, stent placement should follow. Within the first two weeks, thrombosed dural sinus and cerebral venous vessels are typically hyperdense on CT compared with brain parenchyma; after the course of 2 weeks, the thrombus will become isodense. In MRI an axial fluid-attenuated inversion recovery sequence, an axial diffusion-weighted MRI, coronal T1-weighted spin-echo and T2-weighted turbo-spin-echo sequences, a coronal gradient-echo and a 3D phase-contrast venous angiogram should be performed. Local thrombolysis is needed only when patients have an exacerbation of clinical symptoms or imaging signs of worsening disease despite sufficient anticoagulation therapy. Acute occlusions of dia

  19. CHRONIC FEEDING ALCOHOL-CONTAINING DIETS VIA TOTAL ENTERAL NUTRITION INDUCES ALCOHOL DEHYDROGENASE (ADH) AND INSULIN RESISTANCE

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Induction of Class 1 ADH occurs in rats fed alcohol chronically, and we have reported that C/EBPs and SREBP-1 are important signaling factors in this process. Chronic alcohol intake in humans can result in alcohol-induced diabetes. We have studied insulin signaling pathways in adult male Sprague-D...

  20. A unified mathematical model to quantify performance impairment for both chronic sleep restriction and total sleep deprivation.

    PubMed

    Rajdev, Pooja; Thorsley, David; Rajaraman, Srinivasan; Rupp, Tracy L; Wesensten, Nancy J; Balkin, Thomas J; Reifman, Jaques

    2013-08-21

    Performance prediction models based on the classical two-process model of sleep regulation are reasonably effective at predicting alertness and neurocognitive performance during total sleep deprivation (TSD). However, during sleep restriction (partial sleep loss) performance predictions based on such models have been found to be less accurate. Because most modern operational environments are predominantly characterized by chronic sleep restriction (CSR) rather than by episodic TSD, the practical utility of this class of models has been limited. To better quantify performance during both CSR and TSD, we developed a unified mathematical model that incorporates extant sleep debt as a function of a known sleep/wake history, with recent history exerting greater influence. This incorporation of sleep/wake history into the classical two-process model captures an individual's capacity to recover during sleep as a function of sleep debt and naturally bridges the continuum from CSR to TSD by reducing to the classical two-process model in the case of TSD. We validated the proposed unified model using psychomotor vigilance task data from three prior studies involving TSD, CSR, and sleep extension. We compared and contrasted the fits, within-study predictions, and across-study predictions from the unified model against predictions generated by two previously published models, and found that the unified model more accurately represented multiple experimental studies and consistently predicted sleep restriction scenarios better than the existing models. In addition, we found that the model parameters obtained by fitting TSD data could be used to predict performance in other sleep restriction scenarios for the same study populations, and vice versa. Furthermore, this model better accounted for the relatively slow recovery process that is known to characterize CSR, as well as the enhanced performance that has been shown to result from sleep banking. PMID:23623949

  1. Does Total Body Irradiation Conditioning Improve Outcomes of Myeloablative HLA-Identical Sibling Transplants for Chronic Lymphocytic Leukemia?

    PubMed Central

    Sabloff, Mitchell; Sobecks, Ronald M.; Ahn, Kwang Woo; Zhu, Xiaochun; de Lima, Marcos; Brown, Jennifer R.; Inamoto, Yoshihiro; Holland, H. Kent; Aljurf, Mahmoud D.; Laughlin, Mary J.; Kamble, Rammurti T.; Hsu, Jack W.; Wirk, Baldeep M.; Seftel, Matthew; Lewis, Ian D.; Arora, Mukta; Alyea, Edwin P.; Kalaycio, Matt E.; Cortes, Jorge; Maziarz, Richard T.; Gale, Robert Peter; Saber, Wael

    2014-01-01

    An allogeneic hematopoietic cell transplant (HCT) from an HLA-identical donor after high-dose (myeloablative) pre-transplant conditioning, is an effective therapy for some people with chronic lymphocytic leukemia (CLL). Because CLL is a highly radiosensitive cancer, we hypothesized total body irradiation (TBI) conditioning regimens may be associated with better outcomes than those without TBI. To answer this we analyzed data from 180 subjects with CLL receiving myeloablative doses of TBI (N=126) or not (N=54), transplanted from an HLA-identical sibling donor, between 1995 and 2007 and reported to the Center for International Blood & Marrow Transplant Research (CIBMTR). At 5 years, treatment-related mortality was 48% (95% CI, 39–57%) vs. 50% (95% CI, 36–64%); p=NS. Relapse rates were 17% (95% CI, 11–25%) vs. 22% (95% CI, 11–35%); p=NS. Five-year progression-free survival and overall survival was 34% (95% CI, 26–43%) vs. 28% (95% CI, 15–42%); p=NS and 42% (95% CI, 33–51%) vs. 33% (95% CI, 19–48%); p=NS, respectively. The single most common cause of death in both cohorts was recurrent/progressive CLL. No variable tested in the multivariate analysis was found to significantly affect these outcomes including having failed fludarabine. Within the limitations of this study we found no difference in HLA-identical sibling transplant outcomes between myeloablative TBI and chemotherapy pre-transplant conditioning in persons with CLL. PMID:24321745

  2. Veno-occlusive liver disease: a case report.

    PubMed

    Schneider, Jakob; Tsegaye, Yohannes; W/Tensae, Mihret; G/Selassie, Solomon; Haile, Tewodros; Bane, Abate; Ali, Ahmed; Mesfin, Gebrekidan; Seboxa, Teshale

    2012-04-01

    A case of veno-occlusive liver disease (VOLD) in a 12-years old Ethiopian boy is described The salient clinical features and gross and microscopic examination of biopsy material are reviewed. Veno-occlusive disease which occurs in the West Indies, East and West Africa, and India is an acute, subacute or chronic condition that affects the central and sublobular hepatic veins. In the West Indies (1) it is related to the consumption of bush tea made from plants that contain toxic pyrrolizidine alkaloids, such as Crotalaria and Senecio (2). Hepatotoxic compounds in Crotalaria, Senecio, Heliotropium and other composite plants can also enter the diet through the contamination of cereals with weed seeds. For example 28 of 67 patients died with veno-occlusive disease in central India after consuming a local cereal, gondli contaminated with the seeds of Crotalaria (3). Heliotropium Popovii has been implicated in outbreaks in villages in northwestern Afghanistan, with high mortality (4). The primary pathological change of hepatic veno-occlusive disease is sub-endothelial edema followed by intimal growth of connective tissue, with narrowing and occlusion of the central and sub-lobular hepatic veins. Atrophy or necrosis of liver cells, with consequent fibrosis leads to gross changes similar to those seen in cardiac cirrhosis, portal hypertension results. The present report, the first of it kind in Ethiopia describes a case of veno-occlusive liver disease in a 12-year old Ethiopian boy. PMID:22946295

  3. A New Occlusion Device: Application of the ArtVentive Endoluminal Occlusion System (EOS)—First in Human Clinical Trial

    SciTech Connect

    Venbrux, Anthony C., E-mail: avenbrux@mfa.gwu.edu [The George Washington University Medical Center, Division of Vascular and Interventional Radiology (United States); Rudakov, Leon, E-mail: leonrudakov@artventivemedical.com [Artventive Medical Group, Inc. (United States); Plass, Andre, E-mail: andre.plass@usz.ch; Emmert, Maximilian Y., E-mail: maximilian.emmert@usz.ch [University Hospital Zurich, Clinic for Cardiac and Vascular Surgery (Switzerland); Ebner, Adrian, E-mail: adrianebner@fundacor.com.py [Sanatorio Privado Santa Clara, Cath Lab Department (Paraguay)

    2013-05-24

    PurposeThe purpose of this study was to determine the safety and efficacy of a new endoluminal occlusion device, ArtVentive endoluminal occlusion system (EOS), to occlude the spermatic vein in symptomatic males with varicoceles.MethodsThe ArtVentive EOS device has been developed for percutaneous, peripheral occlusion of the peripheral arterial and venous vasculature. The system is comprised of an implantable occlusion device and a delivery catheter. At present, there are two device sizes: (a) size 1 for target vessels ranging between 3.5 and 5.5 mm in diameter, and (b) size 2 for target vessels 5.5–8.5 mm in diameter. The treatment group included six adult males, ages 22–34 years. Nine target vessels were occluded. A total of 20 devices were implanted in six subjects.ResultsThe acute occlusion rate at the end of the procedure was 100 % occurring in nine of nine vessels. The spermatic veins of all patients remained occluded on venography at 30 days follow-up. Pain scores related to varicoceles decreased in five of six patients.ConclusionsAlthough we recognize this study is limited, initial experience indicates that the ArtVentive EOS is a safe and effective new device for occlusion of vessels (varicoceles). The device has potential applications in other clinical conditions requiring occlusion of veins or arteries.

  4. Photoacoustic removal of occlusions from blood vessels

    DOEpatents

    Visuri, Steven R. (Livermore, CA); Da Silva, Luiz B. (Danville, CA); Celliers, Peter M. (Berkeley, CA); London, Richard A. (Orinda, CA); Maitland, IV, Duncan J. (Lafayette, CA); Esch, Victor C. (San Francisco, CA)

    2002-01-01

    Partial or total occlusions of fluid passages within the human body are removed by positioning an array of optical fibers in the passage and directing treatment radiation pulses along the fibers, one at a time, to generate a shock wave and hydrodynamics flows that strike and emulsify the occlusions. A preferred application is the removal of blood clots (thrombin and embolic) from small cerebral vessels to reverse the effects of an ischemic stroke. The operating parameters and techniques are chosen to minimize the amount of heating of the fragile cerebral vessel walls occurring during this photo acoustic treatment. One such technique is the optical monitoring of the existence of hydrodynamics flow generating vapor bubbles when they are expected to occur and stopping the heat generating pulses propagated along an optical fiber that is not generating such bubbles.

  5. Fludarabine Phosphate and Total-Body Irradiation Before Donor Peripheral Blood Stem Cell Transplant in Treating Patients With Chronic Lymphocytic Leukemia or Small Lymphocytic Leukemia

    ClinicalTrials.gov

    2015-06-08

    B-Cell Prolymphocytic Leukemia; Chronic Lymphocytic Leukemia; Prolymphocytic Leukemia; Recurrent Chronic Lymphocytic Leukemia; Recurrent Small Lymphocytic Lymphoma; Refractory Chronic Lymphocytic Leukemia; T-Cell Prolymphocytic Leukemia

  6. A unified mathematical model to quantify performance impairment for both chronic sleep restriction and total sleep deprivation

    E-print Network

    recovery process after chronic sleep restriction. Our model describes the beneficial effects of banking in revised form 28 February 2013 Accepted 12 April 2013 Available online 24 April 2013 Keywords been shown to result from sleep banking. Published by Elsevier Ltd. 1. Introduction Sleepiness

  7. Chronic nitrogen additions reduce total soil respiration and microbial respiration in temperate forest soils at the Harvard Forest

    Microsoft Academic Search

    Richard D. Bowden; Eric Davidson; Kathleen Savage; Chris Arabia; Paul Steudler

    2004-01-01

    Abstract At the Harvard Forest Long-term Ecological Research Site Chronic Nitrogen Amendment Study, a red pine and a mixed deciduous stand showed,immediate,changes in soil respiration following nitrogen additions (low N: 5 g N m, 2 per year), with further reductions in the second year. Weekly measures of soil respiration during summer 2001 showed that after 13 years of continuous nitrogen

  8. Dental occlusion and postural control in adults

    Microsoft Academic Search

    Corinne Tardieu; Michel Dumitrescu; Anne Giraudeau; Jean-Luc Blanc; François Cheynet; Liliane Borel

    2009-01-01

    We studied the influence of a dental occlusion perturbation on postural control. The tests were performed in three dental occlusion conditions: (Rest Position: no dental contact, Maximal Intercuspal Occlusion: maximal dental contact, and Thwarted Laterality Occlusion: simulation of a dental malocclusion) and four postural conditions: static (stable platform) and dynamic (unstable platform), with eyes open and eyes closed. A decay

  9. Aneurysm Formation after Carotid Occlusion

    Microsoft Academic Search

    Paul E. Timperman; Thomas A. Tomsick; John M. Tew; Harry R. van Loveren

    Summary: We present two cases of subarachnoid hemorrhage caused by aneurysm development and enlargement in the ante- rior communicating artery complex. The cases occurred in a series of 58 balloon occlusions for unclippable giant aneurysms of the internal carotid artery.

  10. Occlusal Caries Detection: A Comparison of a Laser Fluorescence System and Conventional Methods

    Microsoft Academic Search

    Cíntia Burin; Cristian Burin; Alessandro Dourado Loguercio; Rosa Helena; Alessandra Reis

    2005-01-01

    Purpose: The purpose of this study was to compare the effectiveness of a laser fluores- cence (LF) device (DIAGNOdent) with a visual and radiographic scoring system for in vitro detection of occlusal caries and to evaluate the effect of 1% NaOCl immersion on the LF readings. Methods: A total of 54 extracted third molars with macroscopically intact occlusal sur- faces

  11. Evaluation of body composition and nitrogen content of renal patients on chronic dialysis as determined by total body neutron activation

    SciTech Connect

    Cohn, S.H.; Brennan, B.L.; Yasumura, S.; Vartsky, D.; Vaswani, A.N.; Ellis, K.J.

    1983-07-01

    Total body protein (nitrogen), body cell mass (potassium), fat, and water were measured in 15 renal patients on maintenance hemodialysis (MHD). Total body nitrogen was measured by means of prompt ..gamma.. neutron activation analysis; total body water was determined with tritium labeled water; total body potassium was measured by whole body counting. The extracellular water was determined by a technique utilizing the measurement of total body chloride and plasma chloride. When compared with corresponding values of a control group of the same age, sex, and height, the protein content, body cell mass, and total body fat of the MHD patients were within the normal range. The only significant change was an increase in the extracellular water/body cell mass ratio in the male MHD patients compared to the control. The lack of significant difference of the nitrogen values of the MHD patients compared to matched controls suggests that dialysis minimizes any residual effects of uremic toxicity or protein-calorie malnutrition. These findings further suggest that there is a need to reevaluate the traditional anthropometric and biochemical standards of nutritional status for MHD patients. It was concluded that it is particularly important to measure protein stores of MHD patients with low protein intake to ascertain nutritional status. Finally, in vivo measurement of total body nitrogen and potassium for determination of body composition provides a simple, direct, and accurate assessment of the nutritional status of MHD patients.

  12. Endoluminal occlusion devices: technology update

    PubMed Central

    Zander, Tobias; Medina, Samantha; Montes, Guillermo; Nuñez-Atahualpa, Lourdes; Valdes, Michel; Maynar, Manuel

    2014-01-01

    Endoluminal occlusion has been performed since the early beginning of interventional radiology. Over recent decades, major technological advances have improved the techniques used and different devices have been developed for changing conditions. Most of these occlusion devices have been implemented in the vascular territory. Early embolization materials included glass particles, hot contrast, paraffin, fibrin, and tissue fragments such as muscle fibers and blood clots; today, occlusion materials include metallic devices, particles, and liquid materials, which can be indicated for proximal or distal occlusion, high-flow and low-flow situations, and in large-caliber and small-caliber vessels, based on need. Technological progress has led to a decreased size of delivery catheters, and an increase in safety due to release systems that permit the withdrawing and replacement of embolization material. Furthermore, bioactive embolization materials have been developed to increase the efficacy of embolization or the biological effect of medication. Finally, materials have been modified for changing indications. Intravascular stents were initially developed to keep an artery open; however, by adding a covering membrane, these stents can be used to occlude the wall of a vessel or other endoluminal structures. This article gives an overview of the devices most utilized for occlusion of endoluminal structures, as well as their major purpose in the endovascular territory. PMID:25489252

  13. Monitoring cerebral oxygenation during balloon occlusion with multichannel NIRS.

    PubMed

    Rummel, Christian; Zubler, Christoph; Schroth, Gerhard; Gralla, Jan; Hsieh, Kety; Abela, Eugenio; Hauf, Martinus; Meier, Niklaus; Verma, Rajeev K; Andres, Robert H; Nirkko, Arto C; Wiest, Roland

    2014-02-01

    We report on oxygenation changes noninvasively recorded by multichannel continuous-wave near infrared spectroscopy (CW-NIRS) during endovascular neuroradiologic interventions requiring temporary balloon occlusion of arteries supplying the cerebral circulation. Digital subtraction angiography (DSA) provides reference data on the site, timing, and effectiveness of the flow stagnation as well as on the amount and direction of collateral circulation. This setting allows us to relate CW-NIRS findings to brain specific perfusion changes. We focused our analysis on the transition from normal perfusion to vessel occlusion, i.e., before hypoxia becomes clinically apparent. The localization of the maximal response correlated either with the core (occlusion of the middle cerebral artery) or with the watershed areas (occlusion of the internal carotid artery) of the respective vascular territories. In one patient with clinically and angiographically confirmed insufficient collateral flow during carotid artery occlusion, the total hemoglobin concentration became significantly asymmetric, with decreased values in the ipsilateral watershed area and contralaterally increased values. Multichannel CW-NIRS monitoring might serve as an objective and early predictive marker of critical perfusion changes during interventions-to prevent hypoxic damage of the brain. It also might provide valuable human reference data on oxygenation changes as they typically occur during acute stroke. PMID:24301292

  14. Monitoring cerebral oxygenation during balloon occlusion with multichannel NIRS

    PubMed Central

    Rummel, Christian; Zubler, Christoph; Schroth, Gerhard; Gralla, Jan; Hsieh, Kety; Abela, Eugenio; Hauf, Martinus; Meier, Niklaus; Verma, Rajeev K; Andres, Robert H; Nirkko, Arto C; Wiest, Roland

    2014-01-01

    We report on oxygenation changes noninvasively recorded by multichannel continuous-wave near infrared spectroscopy (CW-NIRS) during endovascular neuroradiologic interventions requiring temporary balloon occlusion of arteries supplying the cerebral circulation. Digital subtraction angiography (DSA) provides reference data on the site, timing, and effectiveness of the flow stagnation as well as on the amount and direction of collateral circulation. This setting allows us to relate CW-NIRS findings to brain specific perfusion changes. We focused our analysis on the transition from normal perfusion to vessel occlusion, i.e., before hypoxia becomes clinically apparent. The localization of the maximal response correlated either with the core (occlusion of the middle cerebral artery) or with the watershed areas (occlusion of the internal carotid artery) of the respective vascular territories. In one patient with clinically and angiographically confirmed insufficient collateral flow during carotid artery occlusion, the total hemoglobin concentration became significantly asymmetric, with decreased values in the ipsilateral watershed area and contralaterally increased values. Multichannel CW-NIRS monitoring might serve as an objective and early predictive marker of critical perfusion changes during interventions—to prevent hypoxic damage of the brain. It also might provide valuable human reference data on oxygenation changes as they typically occur during acute stroke. PMID:24301292

  15. Partial Occlusion Drawing in Autistic Children 

    E-print Network

    Hodgson, Eleanor

    INTRODUCTION: Partial occlusion drawing in autistic individuals has received little attention in previous research. In normally developing children field independence is positively correlated with partial occlusion drawing (Morra et al., 1996...

  16. Total Pancreatectomy and Islet Auto-Transplantation in Children for Chronic Pancreatitis. Indication, Surgical Techniques, Post Operative Management and Long-Term Outcomes

    PubMed Central

    Chinnakotla, Srinath; Bellin, Melena D.; Schwarzenberg, Sarah J.; Radosevich, David M.; Cook, Marie; Dunn, Ty B.; Beilman, Gregory J.; Freeman, Martin L.; Balamurugan, A.N.; Wilhelm, Josh; Bland, Barbara; Jimenez-Vega, Jose M; Hering, Bernhard J.; Vickers, Selwyn M.; Pruett, Timothy L.; Sutherland, David E.R.

    2014-01-01

    Objective Describe the surgical technique, complications and long term outcomes of total pancreatectomy and islet auto transplantation (TP-IAT) in a large series of pediatric patients. Summary Background Data Surgical management of childhood pancreatitis is not clear; partial resection or drainage procedures often provide transient pain relief, but long term recurrence is common due to the diffuse involvement of the pancreas. Total pancreatectomy (TP) removes the source of the pain, while islet auto transplantation (IAT) potentially can prevent or minimize TP-related diabetes. Methods Retrospective review of 75 children undergoing TP-IAT for chronic pancreatitis who had failed medical, endoscopic or surgical treatment between 1989–2012. Results Pancreatitis pain and the severity of pain statistically improved in 90% of patients after TP-IAT (p =<0.001). The relief from narcotics was sustained. Of the 75 patients undergoing TP-IAT, 31 (41.3%) achieved insulin independence. Younger age (p=0.032), lack of prior Puestow (p=0.018), lower body surface area (p=0.048), IEQ per Kg Body Weight (p=0.001) and total IEQ (100,000) (0.004) were associated with insulin independence. By multivariate analysis, 3 factors were associated with insulin independence after TP-IAT:(1) male gender, (2) lower body surface area and the (3) higher total IEQ per kilogram body weight. Total IEQ (100,000) was the single factor most strongly associated with insulin independence (OR = 2.62; p value < 0.001). Conclusions TP-IAT provides sustained pain relief and improved quality of life. The ? cell function is dependent on islet yield. TP-IAT is an effective therapy for children with painful pancreatitis that fail medical and or endoscopic management PMID:24509206

  17. Intractable pneumothorax managed by talc pleurodesis and bronchial occlusion with spigots.

    PubMed

    Ishida, Atsuko; Kida, Hirotaka; Muraoka, Hiromi; Nishine, Hiroki; Mineshita, Masamichi; Miyazawa, Teruomi

    2015-03-01

    Three cases of inoperable secondary spontaneous pneumothorax were diagnosed in patients with chronic obstructive pulmonary disease. Two cases initially underwent bronchial occlusion with endobronchial Watanabe spigot (EWS), while one underwent talc poudrage with pleuroscopy. As air leaks were not stopped completely in all cases with the initial procedures, we performed additional interventional treatments: pleuroscopic talc poudrage in cases when bronchial occlusion was performed first; and bronchial occlusion with EWS for a case that initially underwent talc pleurodesis. The air leaks ceased in all cases without complication. We successfully removed chest tubes 2-10 days after secondary procedure, which was 10-23 days after the first procedure. The combination of talc pleurodesis and bronchial occlusion with EWS, when a single, initial interventional treatment fails, can be considered in cases of intractable, inoperable secondary pneumothorax. PMID:25802742

  18. Intractable pneumothorax managed by talc pleurodesis and bronchial occlusion with spigots

    PubMed Central

    Ishida, Atsuko; Kida, Hirotaka; Muraoka, Hiromi; Nishine, Hiroki; Mineshita, Masamichi; Miyazawa, Teruomi

    2015-01-01

    Three cases of inoperable secondary spontaneous pneumothorax were diagnosed in patients with chronic obstructive pulmonary disease. Two cases initially underwent bronchial occlusion with endobronchial Watanabe spigot (EWS), while one underwent talc poudrage with pleuroscopy. As air leaks were not stopped completely in all cases with the initial procedures, we performed additional interventional treatments: pleuroscopic talc poudrage in cases when bronchial occlusion was performed first; and bronchial occlusion with EWS for a case that initially underwent talc pleurodesis. The air leaks ceased in all cases without complication. We successfully removed chest tubes 2–10 days after secondary procedure, which was 10–23 days after the first procedure. The combination of talc pleurodesis and bronchial occlusion with EWS, when a single, initial interventional treatment fails, can be considered in cases of intractable, inoperable secondary pneumothorax. PMID:25802742

  19. 5-hydroxytryptamine (5-HT) reduces total peripheral resistance during chronic infusion: direct arterial mesenteric relaxation is not involved.

    PubMed

    Davis, Robert Patrick; Pattison, Jill; Thompson, Janice M; Tiniakov, Ruslan; Scrogin, Karie E; Watts, Stephanie W

    2012-01-01

    Serotonin (5-hydroxytryptamine; 5-HT) delivered over 1 week results in a sustained fall in blood pressure in the sham and deoxycorticosterone acetate (DOCA)-salt rat. We hypothesized 5-HT lowers blood pressure through direct receptor-mediated vascular relaxation. In vivo, 5-HT reduced mean arterial pressure (MAP), increased heart rate, stroke volume, cardiac index, and reduced total peripheral resistance during a 1 week infusion of 5-HT (25 µg/kg/min) in the normotensive Sprague Dawley rat. The mesenteric vasculature was chosen as an ideal candidate for the site of 5-HT receptor mediated vascular relaxation given the high percentage of cardiac output the site receives. Real-time RT-PCR demonstrated that mRNA transcripts for the 5-HT2B, 5-HT1B, and 5-HT7 receptors are present in sham and DOCA-salt superior mesenteric arteries. Immunohistochemistry and Western blot validated the presence of the 5-HT2B, 5- HT1B and 5-HT7 receptor protein in sham and DOCA-salt superior mesenteric artery. Isometric contractile force was measured in endothelium-intact superior mesenteric artery and mesenteric resistance arteries in which the contractile 5- HT2A receptor was antagonized. Maximum concentrations of BW-723C86 (5- HT2B agonist), CP 93129 (5-HT1B agonist) or LP-44 (5-HT7 agonist) did not relax the superior mesenteric artery from DOCA-salt rats vs. vehicle. Additionally, 5-HT (10-9 M to 10-5 M) did not cause relaxation in either contracted mesenteric resistance arteries or superior mesenteric arteries from normotensive Sprague- Dawley rats. Thus, although 5-HT receptors known to mediate vascular relaxation are present in the superior mesenteric artery, they are not functional, and are therefore not likely involved in a 5-HT-induced fall in total peripheral resistance and MAP. PMID:22559843

  20. Symmetric Stereo Matching for Occlusion Handling

    Microsoft Academic Search

    Jian Sun; Yin Li; Sing Bing Kang; Heung-Yeung Shum

    2005-01-01

    In this paper, we propose a symmetric stereo model to han- dle occlusion in dense two-frame stereo. Our occlusion reasoning is directly based on the visibility constraint that is more general than both ordering and uniqueness con- straints used in previous work. The visibility constraint requires occlusion in one image and disparity in the other to be consistent. We embed

  1. The development of dental occlusion

    Microsoft Academic Search

    R. G. Oliver; B. J. Moxham

    2000-01-01

    This paper gives a succinct review of the mechanisms that are believed to be responsible for tooth eruption, the process of tooth eruption, and the stages of occlusal development. Brief reference is made to conditions that lead to disturbance of eruption.

  2. Common carotid artery occlusion: a case series.

    PubMed

    Bajkó, Zoltán; B?la?a, Rodica; Mo????ianu, Anca; Maier, Smaranda; Chebu?, Octavia Claudia; Szatmári, Szabolcs

    2013-01-01

    Subjects and Methods. We analysed 5000 cerebrovascular ultrasound records. A total of 0.4% of the patients had common carotid artery occlusion (CCAO). Results. The mean age was 59.8 ± 14.2 years, and the male/female ratio was 2.33. The most frequent risk factors were hypertension, ischaemic heart disease, dyslipidemia, diabetes mellitus, and smoking. Right-sided and left-sided CCAO occurred in 65% and 30% of the cases, respectively, and bilateral occlusion was detected in one case (5%). Patent bifurcation was observed in 10 cases of CCAO in which the anterograde flow in the ICA was maintained from the external carotid artery with reversed flow. In two of the cases, the occluded CCA was hypoplastic. The aetiology of CCAO in the majority of cases was the atherosclerosis (15 cases). The male/female ratio was higher in the patients with occluded distal vessels, and the short-term outcome was poorer. Only two cases from this series underwent revascularisation surgery. Spontaneous recanalisation was observed in one case. Conclusions. The most frequent cause of CCAO was atherosclerosis. The outcome is improved in the cases with patent distal vessels, and spontaneous recanalisation is possible. Treatment methods have not been standardised. Surgical revascularisation is possible in cases of patent distal vessels, but the indications are debatable. PMID:24167740

  3. Common Carotid Artery Occlusion: A Case Series

    PubMed Central

    Bajkó, Zoltán; B?la?a, Rodica; Mo????ianu, Anca; Maier, Smaranda; Chebu?, Octavia Claudia; Szatmári, Szabolcs

    2013-01-01

    Subjects and Methods. We analysed 5000 cerebrovascular ultrasound records. A total of 0.4% of the patients had common carotid artery occlusion (CCAO). Results. The mean age was 59.8 ± 14.2 years, and the male/female ratio was 2.33. The most frequent risk factors were hypertension, ischaemic heart disease, dyslipidemia, diabetes mellitus, and smoking. Right-sided and left-sided CCAO occurred in 65% and 30% of the cases, respectively, and bilateral occlusion was detected in one case (5%). Patent bifurcation was observed in 10 cases of CCAO in which the anterograde flow in the ICA was maintained from the external carotid artery with reversed flow. In two of the cases, the occluded CCA was hypoplastic. The aetiology of CCAO in the majority of cases was the atherosclerosis (15 cases). The male/female ratio was higher in the patients with occluded distal vessels, and the short-term outcome was poorer. Only two cases from this series underwent revascularisation surgery. Spontaneous recanalisation was observed in one case. Conclusions. The most frequent cause of CCAO was atherosclerosis. The outcome is improved in the cases with patent distal vessels, and spontaneous recanalisation is possible. Treatment methods have not been standardised. Surgical revascularisation is possible in cases of patent distal vessels, but the indications are debatable. PMID:24167740

  4. Three hypothesis algorithm with occlusion reasoning for multiple people tracking

    NASA Astrophysics Data System (ADS)

    Reta, Carolina; Altamirano, Leopoldo; Gonzalez, Jesus A.; Medina-Carnicer, Rafael

    2015-01-01

    This work proposes a detection-based tracking algorithm able to locate and keep the identity of multiple people, who may be occluded, in uncontrolled stationary environments. Our algorithm builds a tracking graph that models spatio-temporal relationships among attributes of interacting people to predict and resolve partial and total occlusions. When a total occlusion occurs, the algorithm generates various hypotheses about the location of the occluded person considering three cases: (a) the person keeps the same direction and speed, (b) the person follows the direction and speed of the occluder, and (c) the person remains motionless during occlusion. By analyzing the graph, our algorithm can detect trajectories produced by false alarms and estimate the location of missing or occluded people. Our algorithm performs acceptably under complex conditions, such as partial visibility of individuals getting inside or outside the scene, continuous interactions and occlusions among people, wrong or missing information on the detection of persons, as well as variation of the person's appearance due to illumination changes and background-clutter distracters. Our algorithm was evaluated on test sequences in the field of intelligent surveillance achieving an overall precision of 93%. Results show that our tracking algorithm outperforms even trajectory-based state-of-the-art algorithms.

  5. [Stagewise bilateral stenting of vertebral arteries in a patient with occlusion of both internal carotid arteries].

    PubMed

    Ter-Akopian, A V; Kalinin, A A; Pankov, A S; Tagaev, N B; Maliutina, E D

    2012-01-01

    The authors describe herein a case report concerning stagewise endovascular treatment of a 69-year-old male patient presenting with occlusion of the right and left internal carotid arteries admitted to Clinical Hospital ? 1 of the RF President's Affairs Administration with the following diagnosis: atherosclerotic occlusion of carotid arteries, arterial hypertension, chronic bronchitis, chronic prostatitis, and a history of multiple episodes of unconsciousness. Duplex scanning and angiography of the brachiocephalic arteries revealed occlusion of the both internal carotid arteries, as well as pronounced narrowing of the ostium of the right and left vertebral arteries supplying blood to all portions of the brain. Computed tomography revealed no signs of endured stroke. The first stage consisted in stenting of critical stenosis of the left vertebral artery ostium, followed by stenting of the right vertebral artery ostium performed 2 weeks after (with implanting drug-covered stents «Promus» in both cases). The patient was discharged home in a satisfactory condition. PMID:22929685

  6. Treatment of chronic unstable angina pectoris: use of a totally implantable programmable device for continuous intrathecal infusion of opiates: case report.

    PubMed

    Segal, R; Murali, S; Tipton, K

    1996-02-01

    We report the case of a 70-year-old man with a 17-year history of angina pectoris, who had previously suffered two documented myocardial infarctions and undergone multiple diagnostic cardiac catheterizations, two coronary artery bypass operations, and several percutaneous transluminal coronary angioplasty procedures. The patient had experienced unstable angina for the past 3 years refractory to maximal medical therapy and was unsuitable for further attempts at revascularization. After a successful trial of epidural infusion of morphine, a totally implantable programmable continuous-infusion device with an intrathecal catheter was implanted in the patient on August 18, 1993, resulting in maintained pain resolution. His gardening, carpentry, and other activities of daily living were limited only by shortness of breath. Six months later, the pump treatment did not mask the development of a myocardial infarction. To the best of our knowledge, this is the first report of the use of continuous intrathecal infusion of morphine or the use of a totally implantable programmable infusion device for angina pectoris. We propose that in carefully selected patients with chronic unstable angina, continuous intrathecal infusion of morphine may relieve effort-induced pain without resulting in myocardial infarction. PMID:8869068

  7. Resolution of Inferior venous baffle leak and total venous occlusion using a bare stent and the gore® excluder® aortic extension in transposition of the great arteries after mustard procedure.

    PubMed

    Ross, Michael M; Schamberger, Marcus S; Hoyer, Mark H

    2014-06-27

    We present a patient with a history of Mustard repair for transposition of the great arteries. The patient presented with complete inferior venous baffle obstruction and a large baffle leak after several years of cyanosis. Complete relief of the obstruction and exclusion of the baffle leak were accomplished with the use of a combination of bare metal stenting and the Gore® Excluder® aortic extender. To our knowledge this represents the first reported use of the Gore® Excluder® aortic extender in the setting of inferior venous baffle leak and associated total inferior vena cava obstruction. © 2014 Wiley Periodicals, Inc. PMID:24976189

  8. Effect of total lymphoid irradiation on functional status in chronic multiple sclerosis: importance of lymphopenia early after treatment--the pros

    SciTech Connect

    Devereux, C.; Troiano, R.; Zito, G.; Devereux, R.B.; Kopecky, K.J.; Friedman, R.; Dowling, P.C.; Hafstein, M.P.; Rohowsky-Kochan, C.; Cook, S.D.

    1988-07-01

    To determine whether immunosuppression by total lymphoid irradiation (TLI) slowed deterioration of chronic progressive multiple sclerosis (MS), functional impairment score and blood lymphocyte counts were compared at 6-month intervals through 4 years following treatment of MS patients by either TLI (n = 27) or sham irradiation (n = 21). At each interval, 20 to 30% fewer TLI-treated patients had deteriorated (p less than 0.05 at 6, 12, and 18 months), and the difference in mean functional impairment score between groups became progressively greater (p less than 0.01 at 42 and 48 months). Benefit accrued principally to the 17 TLI-treated patients with absolute blood lymphocyte counts less than 900/mm3 3 months after treatment, whose mean functional impairment score remained within 0.6 units of baseline (p = NS), whereas the ten TLI patients with higher post-treatment lymphocyte counts had progressive deterioration (p less than 0.05 to p less than 0.001 versus TLI-treated patients with lower lymphocyte counts at all intervals except 30 months) and had deteriorated by more than 5 functional scale units by 42 and 48 months. Side effects were minor and complications rare in TLI-treated patients, but one TLI-treated patient developed staphylococcal sepsis. Thus, TLI slows deterioration of chronic progressive MS, with what appears to be enduring benefit through 4 years compartmented to patients with greater induced lymphopenia. Modification of lymphoid irradiation regimens to increase the proportion of MS patients who achieve a favorable degree of lymphopenia and to avert functional hyposplenism may further improve the benefit/risk ratio.

  9. Thermography in Occlusive Cerebrovascular Diseases

    PubMed Central

    Mawdsley, C.; Samuel, E.; Sumerling, M. D.; Young, G. B.

    1968-01-01

    Cooling of the skin over the medial supraorbital region in 80% of patients who have an occlusion or severe stenosis of a carotid artery can be demonstrated by facial thermography. Minor stenotic lesions in the carotid arteries do not produce characteristic thermographic changes, while thermography is of no help in the diagnosis of vertebrobasilar arterial disease. Thermographic changes suggestive of carotid arterial lesions are found occasionally in patients whose angiograms are normal, owing to variations in the size of the frontal sinuses, or factors such as fever or inflammatory lesions. It is suggested that facial thermography is of value in the preliminary investigation of patients with occlusive cerebrovascular disease. ImagesFig. 1Fig. 2Fig. 3Fig. 4Fig. 5Fig. 6 PMID:5676953

  10. Occlusal caries diagnosis in permanent teeth: an in vitro study Diagnóstico de cárie oclusal em dentes permanentes: estudo in vitro

    Microsoft Academic Search

    Braz Oral Res; Gisele Angnes; Vivian Angnes; Rosa Helena; Miranda Grande; Márcio Battistella; Alessandro Dourado Loguercio; Alessandra Reis

    The reduction in caries prevalence has not occurred uniformly for all dental surfaces. As the occlusal surfaces are still the most likely sites for the development of lesions, new methods of diagnosis are still being evalu- ated. This study compared a laser fluorescence (LF) system (DIAGNOdent) with the Ekstrand's visual system for in vitro detection of occlusal caries. A total

  11. Vascular tumors simulating occlusive disease.

    PubMed

    Schröder, A; Peters, A; Riepe, G; Larena, A; Meierling, S; Mentzel, T; Katenkamp, D; Imig, H

    2001-02-01

    Two cases of vascular tumors of large vessels with intraluminal growth simulating venous thrombosis and arterial occlusive disease are reported. One was a borderline malignant epithelioid hemangioendothelioma of the femoral vein and the other a malignant epithelioid angiosarcoma of the carotid artery. Immunohistochemical studies permitted to classify the tumors. Treatment consisted in surgical resection. No recurrence and no metastasis are noted at 24 months. Uncertainty regarding biological behaviour of vascular tumors and treatment persists. PMID:11284093

  12. Acute effects of granulocyte colony-stimulating factor on early ventricular arrhythmias after coronary occlusion in rats

    PubMed Central

    Baldo, Marcelo Perim; Rodrigues, Sérgio Lamêgo; Mill, José Geraldo

    2012-01-01

    Objectives: To evaluate the acute effects of colony-stimulating factor (G-CSF) on ventricular arrhythmias after coronary occlusion in rats. Materials and Methods: Male Wistar rats (10 weeks) received G-CSF (100 ?g.kg-1) or vehicle. Thirty minutes later, animals were infarcted by coronary occlusion under artificial respiration. Electrocardiogram was monitored for 30 min to evaluate ventricular arrhythmias. Results: G-CSF treatment reduced the number of premature ventricular beats and the number and duration of ventricular tachycardia. The incidence of ventricular fibrillation was significantly reduced by G-CSF (MI-Cont: 11.2 ± 2.4 vs. MI-GCSF: 5.4 ± 1 events; P < 0.05). However, total duration of ventricular fibrillation was not altered (MI-Cont: 84 ± 16 vs. MI-GCSF: 76 ± 13 sec). Conclusions: Acute administration of G-CSF before coronary ligature in rats reduces the incidence of ventricular premature beats and ventricular tachycardia, suggesting a possible direct electrophysiological effect of this cytokine independently of its genomic effects. However, the data suggest that G-CSF treatment may affect the spontaneous recovery from ventricular fibrillation. Acute G-CSF administration acts directly on cardiac electrophysiology, different from chronic treatment. PMID:22368415

  13. Facial height in Japanese-Brazilian descendants with normal occlusion

    PubMed Central

    Vieira, Fabiano Paiva; Pinzan, Arnaldo; Janson, Guilherme; Fernandes, Thais Maria Freire; Sathler, Renata Carvalho; Henriques, Rafael Pinelli

    2014-01-01

    OBJECTIVE: The aim of this study was to determine the standards of facial height in 30 young (14-year-old) Japanese-Brazilian descendants with normal occlusion, and assess whether sexual dimorphism is evident. METHODS: The cephalometric measurements used followed the analyses by Wylie-Johnson, Siriwat-Jarabak, Gebeck, Merrifield and Horn. RESULTS: Results showed dimorphism for total anterior facial height (TAFH), lower anterior facial height (LAFH), anterior facial height (AFH), total posterior facial height (TPFH) and upper posterior facial height (UPFH) measurements. CONCLUSIONS: The standards of facial heights in young Japanese-Brazilian descendants with normal occlusion were observed. Sexual dimorphism was identified in five out of thirteen evaluated variables at this age range. PMID:25715717

  14. Longitudinal trajectory of sexual functioning after hematopoietic cell transplantation: impact of chronic graft-versus-host disease and total body irradiation

    PubMed Central

    Wong, F. Lennie; Francisco, Liton; Togawa, Kayo; Kim, Heeyoung; Bosworth, Alysia; Atencio, Liezl; Hanby, Cara; Grant, Marcia; Kandeel, Fouad; Forman, Stephen J.

    2013-01-01

    This prospective study described the trajectory of sexual well-being from before hematopoietic cell transplantation (HCT) to 3 years after in 131 allogeneic and 146 autologous HCT recipients using Derogatis Interview for Sexual Function and Derogatis Global Sexual Satisfaction Index. Sixty-one percent of men and 37% of women were sexually active pre-HCT; the prevalence declined to 51% (P = .01) in men and increased to 48% (P = .02) in women at 3 years post-HCT. After HCT, sexual satisfaction declined in both sexes (P < .001). All sexual function domains were worse in women compared with men (P ? .001). Orgasm (P = .002) and drive/relationship (P < .001) declined in men, but sexual cognition/fantasy (P = .01) and sexual behavior/experience (P = .01) improved in women. Older age negatively impacted sexual function post-HCT in both sexes (P < .01). Chronic graft-versus-host disease was associated with lower sexual cognition/fantasy (P = .003) and orgasm (P = .006) in men and sexual arousal (P = .05) and sexual satisfaction (P = .005) in women. All male sexual function domains declined after total body irradiation (P < .05). This study identifies vulnerable subpopulations that could benefit from interventional strategies to improve sexual well-being. PMID:24159171

  15. Long-term ambient concentrations of total suspended particulates and oxidants as related to incidence of chronic disease in California Seventh-Day Adventists

    SciTech Connect

    Abbey, D.E.; Mills, P.K.; Petersen, F.F.; Beeson, W.L. (Loma Linda Univ. School of Medicine, CA (United States))

    1991-08-01

    Cancer incidence and mortality in a cohort of 6000 nonsmoking California Seventh-Day Adventists were monitored for a 6-year period, and relationships with long-term cumulative air pollution were observed. Total suspended particulates (TSP) and ozone were measured in terms of numbers of hours in excess of several threshold levels corresponding to national standards as well as mean concentration. For all malignant neoplasms among females, risk increased with increasing exceedance frequencies of all thresholds of TSP except the lowest one, and those increased risks were highly statistically significant. For respiratory cancers, increased risk was associated with only one threshold of ozone, and this result was of borderline significance. Respiratory disease symptoms were assessed in 1977 and again in 1987 using the National Heart, Lung and Blood Institute respiratory symptoms questionnaire on a subcohort of 3914 individuals. Multivariate analyses which adjusted for past and passive smoking and occupational exposures indicated statistically significantly elevated relative risks ranging up to 1.7 for incidence of asthma, definite symptoms of airway obstructive disease, and chronic bronchitis with TSP in excess of all thresholds except the lowest one but not for any thresholds of ozone. A trend association was noted between the threshold of 10 pphm ozone and incidence of asthma. These results are presented within the context of standards setting for these constituents of air pollution.

  16. Transarterial platinum coil occlusion of ruptured intracranial aneurysms: results in 51 patients

    Microsoft Academic Search

    H. T ApSimon; M. S Khangure; N Knuckey; W McAuliffe; F. J Ives

    1998-01-01

    Fifty-one patients with subarachnoid haemorrhage (SAH) due to ruptured intracranial aneurysm have been treated by the Guglielmi detachable platinum coil (GDC) treatment method; 36 patients within 28 days of the ictus. There was total body occlusion in 64.8%, subtotal body occlusion in 24.1% and failed coil placement in 11.1%. Technical success rates were highest in aneurysms with neck sizes up

  17. Ocular neovascularization in eyes with a central retinal artery occlusion or a branch retinal artery occlusion

    PubMed Central

    Mason, John O; Patel, Shyam A; Feist, Richard M; Albert, Michael A; Huisingh, Carrie; McGwin, Gerald; Thomley, Martin L

    2015-01-01

    Purpose To investigate the ocular neovascularization (ONV) rate in eyes with a branch retinal artery occlusion (BRAO) or a central retinal artery occlusion (CRAO), and to study factors that may influence the ONV rate secondary to CRAO. Methods This was a retrospective case series of consecutive patients (286 total eyes: 83 CRAOs and 203 BRAOs) who were diagnosed with a retinal artery occlusion from 1998 to 2013 at the Retina Consultants of Alabama and University of Alabama at Birmingham, Birmingham, AL, USA. Generalized estimating equations were used to evaluate the association between hypothesized risk factors and ONV development. Results Twelve (14.5%) of the 83 eyes with a CRAO developed ONV. Eleven of 12 eyes (91.7%) had iris neovascularization, ten of 12 eyes (83.3%) had neovascular glaucoma, and two of 12 eyes (16.7%) had neovascularization of the optic disc. The average time for ONV development secondary to CRAO was 30.7 days, ranging from the date of presentation to 137 days. Only two (<1.0%) of the 203 eyes with a BRAO developed iris neovascularization. Diabetes mellitus type 2 was a risk factor for ONV development following a CRAO with an adjusted odds ratio of 5.2 (95% confidence interval: 1.4–19.8) (P=0.02). Conclusion ONV is an important complication of CRAO and is a less-frequent complication of BRAO. Patients with a CRAO, especially those with diabetes mellitus type 2, should be closely monitored for the first 6 months for ONV.

  18. Vertebral artery occlusion and oral contraceptives.

    PubMed Central

    Ask-Upmark, E; Bickerstaff, E R

    1976-01-01

    If vertebral artery occlusion occurs in degenerative arterial disease it is almost invariably left-sided, but in vertebral artery deficiency syndromes associated with oral contraceptives a striking preponderance of right-sided involvement has been shown. This observation adds support to the view that causes other than changes in the wall of the vessel at the site of occlusion must be sought as an explanation of the occlusion. PMID:1252812

  19. ACUTE RETINAL ARTERIAL OCCLUSIVE DISORDERS

    PubMed Central

    Hayreh, Sohan Singh

    2011-01-01

    The initial section deals with basic sciences; among the various topics briefly discussed are the anatomical features of ophthalmic, central retinal and cilioretinal arteries which may play a role in acute retinal arterial ischemic disorders. Crucial information required in the management of central retinal artery occlusion (CRAO) is the length of time the retina can survive following that. An experimental study shows that CRAO for 97 minutes produces no detectable permanent retinal damage but there is a progressive ischemic damage thereafter, and by 4 hours the retina has suffered irreversible damage. In the clinical section, I discuss at length various controversies on acute retinal arterial ischemic disorders. Classification of acute retinal arterial ischemic disorders These are of 4 types: CRAO, branch retinal artery occlusion (BRAO), cotton wools spots and amaurosis fugax. Both CRAO and BRAO further comprise multiple clinical entities. Contrary to the universal belief, pathogenetically, clinically and for management, CRAO is not one clinical entity but 4 distinct clinical entities – non-arteritic CRAO, non-arteritic CRAO with cilioretinal artery sparing, arteritic CRAO associated with giant cell arteritis (GCA) and transient non-arteritic CRAO. Similarly, BRAO comprises permanent BRAO, transient BRAO and cilioretinal artery occlusion (CLRAO), and the latter further consists of 3 distinct clinical entities - non-arteritic CLRAO alone, non-arteritic CLRAO associated with central retinal vein occlusion and arteritic CLRAO associated with GCA. Understanding these classifications is essential to comprehend fully various aspects of these disorders. Central retinal artery occlusion The pathogeneses, clinical features and management of the various types of CRAO are discussed in detail. Contrary to the prevalent belief, spontaneous improvement in both visual acuity and visual fields does occur, mainly during the first 7 days. The incidence of spontaneous visual acuity improvement during the first 7 days differs significantly (p<0.001) among the 4 types of CRAO; among them, in eyes with initial visual acuity of counting finger or worse, visual acuity improved, remained stable or deteriorated in nonarteritic CRAO in 22%, 66% and 12% respectively; in nonarteritic CRAO with cilioretinal artery sparing in 67%, 33% and none respectively; and in transient nonarteritic CRAO in 82%, 18% and none respectively. Arteritic CRAO shows no change. Recent studies have shown that administration of local intra-arterial thrombolytic agent not only has no beneficial effect but also can be harmful. Prevalent multiple misconceptions on CRAO are discussed. Branch retinal artery occlusion Pathogeneses, clinical features and management of various types of BRAO are discussed at length. The natural history of visual acuity outcome shows a final visual acuity of 20/40 or better in 89% of permanent BRAO cases, 100% of transient BRAO and 100% of nonarteritic CLRAO alone. Cotton wools spots These are common, non-specific acute focal retinal ischemic lesions, seen in many retinopathies. Their pathogenesis and clinical features are discussed in detail. Amaurosis fugax Its pathogenesis, clinical features and management are described. PMID:21620994

  20. [Acute peripheral arterial occlusive disease].

    PubMed

    Schumann, Romy; Rieger, Johannes; Ludwig, Malte

    2007-06-15

    Acute lower limb ischemia is not infrequently associated with limb loss 10-30%) or death of the affected patient (15-30%). Thus, acute lower limb ischemia is an emergency. There are two categories of acute arterial occlusion: embolism (70-80%) and thrombosis (20-30%). Early diagnosis is a prerequisite for optimal management. Initial clinical examination is the crucial point: it makes the diagnosis of acute ischemia, localizes the level of occlusion, collects etiologic information and allows for assessing the local and general impact of ischemia on the patient. If sensation and motor function are present, viability of the limb is not threatened (incomplete limb ischemia), and good results can be obtained by utilizing anticoagulation and delayed elective revascularization, if the latter is indicated. If the patient, however, presents symptoms of a complete limb ischemia (paralysis or anesthesia is present), then ultimate limb loss is likely. Most patients present with subtle findings and lack classic symptoms, which makes the diagnosis difficult. The standard office-based tests to determine the presence of acute peripheral vascular disease are calculation of the ankle-brachial index and color duplex sonography. Up to now, digital subtraction angiography is used as standard of reference for definitive localization of the occlusion before revascularization. Magnetic resonance arteriography may be helpful when symptoms or findings do not correlate with the noninvasive ultrasound methods. Therapeutic choices are high-dose heparin therapy, surgical removal of the clot, mechanical interventional thrombectomy, and/or catheter-directed thrombolysis - the ultimate choice being dependent on the particular status of the patient. Patients with severe ischemia require immediate surgical intervention. In patients with contraindications to surgical management or incomplete ischemia, interventional revascularization is the therapy of primary choice. Successful outcome is dependent on careful clinical assessment and a prompt multidisciplinary approach to revascularization. PMID:17571221

  1. 21 CFR 870.2890 - Vessel occlusion transducer.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ...2010-04-01 2010-04-01 false Vessel occlusion transducer. 870.2890 Section 870...Monitoring Devices § 870.2890 Vessel occlusion transducer. (a) Identification. A vessel occlusion transducer is a device used to...

  2. Robust Multiple Car Tracking with Occlusion Reasoning

    Microsoft Academic Search

    Dieter Koller; Joseph Weber; Jitendra Malik

    1994-01-01

    Abstract: In this work we address the problem of occlusion in tracking multiple 3D objects in a knownenvironment and propose a new approach for tracking vehicles in road traffic scenes using anexplicit occlusion reasoning step. We employ a contour tracker based on intensity and motionboundaries. The motion of the contour of the vehicles in the image is assumed to be

  3. Estimation of dental occlusion defects among twins

    Microsoft Academic Search

    AGNIESZKA SZULGAN-M?DRZAK; BOHDAN GWORYS

    Occlusion defects are dependent on genetic factors strongly determination facial part of cranium structure and environmental factors. The assessment of these factors might contribute to the correction of therapeutic and prophylactic orthodontic proceedings . The aim of research is to estimate human occlusion defect among pairs of twins of the same gender and pairs of different gender. The research was

  4. The effect of occlusal forces on restorations.

    PubMed

    Larson, Thomas D

    2014-09-01

    This review will focus on the effect occlusal forces, both normal masticatory force and paranormal bruxing and clenching force, have on various restorative materials and their interaction with the teeth through a variety of bonding mechanisms. Salient physical properties of each of the materials will be reviewed, as well as the effect occlusal force has on restoration durability. PMID:25318197

  5. The effect of occlusal forces on restorations.

    PubMed

    Larson, Thomas D

    2012-01-01

    This review will focus on the effect occlusal forces, both normal masticatory force and paranormal bruxing and clenching force, have on various restorative materials and their interaction with the teeth through a variety of bonding mechanisms. Salient physical properties of each of the materials will be reviewed, as well as the effect occlusal force has on restoration durability. PMID:23346657

  6. Detecting natural occlusion boundaries using local cues

    PubMed Central

    DiMattina, Christopher; Fox, Sean A.; Lewicki, Michael S.

    2012-01-01

    Occlusion boundaries and junctions provide important cues for inferring three-dimensional scene organization from two-dimensional images. Although several investigators in machine vision have developed algorithms for detecting occlusions and other edges in natural images, relatively few psychophysics or neurophysiology studies have investigated what features are used by the visual system to detect natural occlusions. In this study, we addressed this question using a psychophysical experiment where subjects discriminated image patches containing occlusions from patches containing surfaces. Image patches were drawn from a novel occlusion database containing labeled occlusion boundaries and textured surfaces in a variety of natural scenes. Consistent with related previous work, we found that relatively large image patches were needed to attain reliable performance, suggesting that human subjects integrate complex information over a large spatial region to detect natural occlusions. By defining machine observers using a set of previously studied features measured from natural occlusions and surfaces, we demonstrate that simple features defined at the spatial scale of the image patch are insufficient to account for human performance in the task. To define machine observers using a more biologically plausible multiscale feature set, we trained standard linear and neural network classifiers on the rectified outputs of a Gabor filter bank applied to the image patches. We found that simple linear classifiers could not match human performance, while a neural network classifier combining filter information across location and spatial scale compared well. These results demonstrate the importance of combining a variety of cues defined at multiple spatial scales for detecting natural occlusions. PMID:23255731

  7. Dysarthria during basilar artery balloon occlusion.

    PubMed

    Hartmann, A; Conolly, E S; Duong, D H; Prestigiacomo, C J; Joshi, S; Mohr, J P; Mast, H

    1999-07-22

    A 49-year-old woman presenting with recurrent, reversible brainstem symptoms and a distal basilar artery aneurysm underwent balloon test occlusion. Five minutes after balloon inflation she developed a reversible isolated dysarthria. Despite failing the test occlusion (and after an additional brainstem event), the patient underwent surgery with placement of a clip across the basilar artery. The operation was tolerated without complication. The authors conclude that 1) pure dysarthria may be a symptom of temporary basilar artery occlusion and 2) balloon testing may overestimate the risk of basilar artery clipping. PMID:10430442

  8. Evaluation of body composition and nitrogen content of renal patients on chronic dialysis as determined by total body neutron activation13

    Microsoft Academic Search

    Stanton H Cohn; B Lawrence Brennan; Seiichi Yasumura; David Vartsky; Ashok N Vaswani; Kenneth J Ellis

    Total body protein (nitrogen), body cell mass (potassium), fat, and water were measured in 15 renal patients on maintenance hemodialysis (MHD). Total body nitrogen was measured by means of prompt y neutron activation analysis; total body water was determined with tritium labeled water; total body potassium was measured by whole body counting. The extracellular water was determined by a technique

  9. Stent Graft in Managing Juxta-Renal Aortoiliac Occlusion

    SciTech Connect

    Prabhudesai, V., E-mail: v_prabhudesai@hotmail.com; Mitra, K.; West, D. J. [NorthStaffordshire Hospital NHS Trust, Newcastle-under-Lyme, ST4 6QG, Department of Radiology (United Kingdom); Dean, M. R. E. [Royal ShrewsburyHospital, Mytton Oak Road, Shrewsbury, SY3 8XQ (United Kingdom)

    2003-09-15

    Endovascular procedures are frequently used as an alternative to surgical bypass in aortic and iliac occlusion. Stents have revolutionized the scope of such endovascular procedures, but there are few reports of stents or stent grafts in occlusive juxta-renal aortic occlusion. We present a case where such occlusion was managed by use of a stent graft with successful outcome.

  10. Biological and biomechanical perspectives of normal dental occlusion

    Microsoft Academic Search

    Makoto Watanabe; Yoshinori Hattori; Chiaki Satoh

    2005-01-01

    From a biological or morphological perspective, it has been accepted that normal dental occlusion requires an even and simultaneous contact of all possible teeth. On the other hand, from a biomechanical perspective, normal dental occlusion also requires adequately distributed occlusal loads on the dental arch and axial loading of occlusal force on each tooth. However, the scientific basis for this

  11. A novel route of revascularization in basilar artery occlusion and review of the literature.

    PubMed

    Morales, Alejandro; Parry, Phillip Vaughan; Jadhav, Ashutosh; Jovin, Tudor

    2015-01-01

    Ischemia of the basilar artery is one of the most devastating types of arterial occlusive disease. Despite treatment of basilar artery occlusions (BAO) with intravenous tissue plasminogen activator, antiplatelet agents, intra-arterial therapy or a combination, fatality rates remain high. Aggressive recanalization with mechanical thrombectomy is therefore often necessary to preserve life. When direct access to the basilar trunk is not possible, exploration of chronically occluded vessels through collaterals with angioplasty and stenting creates access for manual aspiration. We describe the first report of retrograde vertebral artery (VA) revascularization using thyrocervical collaterals for anterograde mechanical aspiration of a BAO followed by stenting of the chronically occluded VA origin. Our novel retrograde-anterograde approach resulted in resolution of the patient's clinical stroke syndrome. PMID:26055597

  12. The antioxidant n-acetylcysteine reduced necrosis, but exacerbated liver fibrosis induced by chronic alcohol in rats fed via total enteral nutrition

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Despite many years of research, the molecular mechanisms underlying progression of alcoholic liver injury from simple steatosis through steatohepatitis and fibrosis remain in dispute. In the current study male Sprague-Dawley rats (350 g) were chronically fed a high unsaturated fat diet for 120 d usi...

  13. Experience with the Use of an Iron Polymaltose (Dextrin) Complex Given by Single Total Dose Infusion to Stable Chronic Haemodialysis Patients

    Microsoft Academic Search

    Roal van Zyl-Smit; Janet A. Halkett

    2002-01-01

    Background: Many studies of anaemia in patients on chronic haemodialysis have noted a high prevalence of iron deficiency despite oral iron supplementation. Our study examined the effect of intravenous iron given as bolus replacement. As the majority of these patients were not receiving concurrent recombinant human erythropoietin (rhEPO) it allowed an analysis of the safety and efficacy of intravenous iron

  14. Gas occlusions in arterial heat pipes.

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.

    1973-01-01

    Experimental and theoretical work on the isothermal dissolution of gas occlusions in arterial heat pipes has been conducted. Theoretical results show critical design factors and gas/fluid properties which affect dissolution of occlusions. The experimental work was in two phases. The first experimentally determined the solubility and diffusivity of helium and argon in ammonia, Freon-21, and methanol. The second utilized physical property data and models to explain dissolution phenomena. Theoretical agreement with experimental results is satisfactory.

  15. DiagnosticsOcclusal caries: wherefore art thou?

    Microsoft Academic Search

    Anthony S. Blinkhorn

    2001-01-01

    ObjectiveTo compare the accuracy and repeatability of three diagnostic systems (DIAGNOdent, visual and radiographic) for occlusal caries diagnosis in primary molars.DesignTwo examiner, in vitro, blinded study. Histological gold standard.Materials and methods58 occlusal surfaces of primary molars examined in turn by two examiners using each of three diagnostic systems (DIAGNOdent, visual and radiographic). These results were compared with a histological gold

  16. Stenting in Acute Lower Limb Arterial Occlusions

    SciTech Connect

    Raja, Jowad; Munneke, Graham; Morgan, Robert; Belli, Anna-Maria, E-mail: anna.belli@stgeorges.nhs.u [St George's Hospital, Department of Radiology (United Kingdom)

    2008-07-15

    Management of critical limb ischemia of acute onset includes surgical embolectomy, bypass grafting, aspiration thrombectomy, thrombolysis, and mechanical thrombectomy followed by treatment of the underlying cause. We present our experience with the use of stents to treat acute embolic/thrombotic occlusions in one iliac and three femoropopliteal arteries. Although this is a small case series, excellent immediate and midterm results suggest that stenting of acute occlusions of the iliac, superficial femoral, and popliteal arteries is a safe and effective treatment option.

  17. Dentition planning with image-based occlusion analysis

    Microsoft Academic Search

    Ferenc Pongrácz; Zoltán Bárdosi

    2006-01-01

    Purpose To develop an easy-to-use, dentition planning method which is based on three-dimensional (3D) computer planning technology to replace conventional plaster-cast occlusion planning techniques.\\u000a Methods  The optimal dental occlusion is defined according to the condition of centric occlusion, i.e. after bringing occlusal surfaces of mandibular and opposing maxillary arches into identical 3D position. This identical position of occlusal surfaces represents

  18. Inhibition of vascular nitric oxide after rat chronic brain hypoperfusion: spatial memory and immunocytochemical changes

    Microsoft Academic Search

    Jack C de la Torre; Gjumrakch Aliev; JC de la Torre

    2005-01-01

    An aging rat model of chronic brain hypoperfusion (CBH) that mimics human mild cognitive impairment (MCI) was used to examine the role of nitric oxide synthase (NOS) isoforms on spatial memory function. Rats with CBH underwent bilateral common carotid artery occlusion (2-vessel occlusion (2-VO)) for either 26 or 8 weeks and were compared with nonoccluded sham controls (S-VO). The neuronal

  19. Workflow Optimization in Vertebrobasilar Occlusion

    SciTech Connect

    Kamper, Lars, E-mail: lars.kamper@helios-kliniken.de; Meyn, Hannes [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany); Rybacki, Konrad [University Hospital, Department of Diagnostic Radiology (Germany); Nordmeyer, Simone [St. Josef-Hospital Oberhausen, Department of Psychiatry and Psychotherapy (Germany); Kempkes, Udo; Piroth, Werner [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany); Isenmann, Stefan [University Hospital Witten/Herdecke, Department of Neurology, HELIOS Klinikum Wuppertal (Germany); Haage, Patrick [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany)

    2012-06-15

    Objective: In vertebrobasilar occlusion, rapid recanalization is the only substantial means to improve the prognosis. We introduced a standard operating procedure (SOP) for interventional therapy to analyze the effects on interdisciplinary time management. Methods: Intrahospital time periods between hospital admission and neuroradiological intervention were retrospectively analyzed, together with the patients' outcome, before (n = 18) and after (n = 20) implementation of the SOP. Results: After implementation of the SOP, we observed statistically significant improvement of postinterventional patient neurological status (p = 0.017). In addition, we found a decrease of 5:33 h for the mean time period from hospital admission until neuroradiological intervention. The recanalization rate increased from 72.2% to 80% after implementation of the SOP. Conclusion: Our results underscore the relevance of SOP implementation and analysis of time management for clinical workflow optimization. Both may trigger awareness for the need of efficient interdisciplinary time management. This could be an explanation for the decreased time periods and improved postinterventional patient status after SOP implementation.

  20. Chronic Non-Orthopedic Conditions More Common in Patients with Less Severe Degenerative Changes That Have Elected to Undergo Total Knee Arthroplasty.

    PubMed

    Jacobs, Cale A; Christensen, Christian P; Karthikeyan, Tharun

    2015-07-01

    The purpose of this study was to determine whether the prevalence of chronic non-orthopedic conditions that may play a role in an abnormal pain response differs between patients based on the severity of degenerative changes at the time of surgery. Of 1020 OA knees that had undergone primary TKA with a minimum 2year follow-up, we identified 117 (11.5%) that had less severe degenerative changes. The prevalence of dissatisfaction was significantly greater in less severe group compared to those with moderate or severe changes (18.8% vs. 9.3%, P=.003). Chronic non-orthopedic conditions were significantly more prevalent in the less severe group with 41.9% reporting depression/anxiety, 30.8% with fibromyalgia or low back pathology, and 12.8% with a prior traumatic brain injury or stroke. PMID:25702593

  1. Growth and hemodynamics after early embryonic aortic arch occlusion.

    PubMed

    Lindsey, Stephanie E; Menon, Prahlad G; Kowalski, William J; Shekhar, Akshay; Yalcin, Huseyin C; Nishimura, Nozomi; Schaffer, Chris B; Butcher, Jonathan T; Pekkan, Kerem

    2015-08-01

    The majority of severe clinically significant forms of congenital heart disease (CHD) are associated with great artery lesions, including hypoplastic, double, right or interrupted aortic arch morphologies. While fetal and neonatal interventions are advancing, their potential ability to restore cardiac function, optimal timing, location, and intensity required for intervention remain largely unknown. Here, we combine computational fluid dynamics (CFD) simulations with in vivo experiments to test how individual pharyngeal arch artery hemodynamics alter as a result of local interventions obstructing individual arch artery flow. Simulated isolated occlusions within each pharyngeal arch artery were created with image-derived three-dimensional (3D) reconstructions of normal chick pharyngeal arch anatomy at Hamburger-Hamilton (HH) developmental stages HH18 and HH24. Acute flow redistributions were then computed using in vivo measured subject-specific aortic sinus inflow velocity profiles. A kinematic vascular growth-rendering algorithm was then developed and implemented to test the role of changing local wall shear stress patterns in downstream 3D morphogenesis of arch arteries. CFD simulations predicted that altered pressure gradients and flow redistributions were most sensitive to occlusion of the IVth arches. To evaluate these simulations experimentally, a novel in vivo experimental model of pharyngeal arch occlusion was developed and implemented using two-photon microscopy-guided femtosecond laser-based photodisruption surgery. The right IVth arch was occluded at HH18, and resulting diameter changes were followed for up to 24 h. Pharyngeal arch diameter responses to acute hemodynamic changes were predicted qualitatively but poorly quantitatively. Chronic growth and adaptation to hemodynamic changes, however, were predicted in a subset of arches. Our findings suggest that this complex biodynamic process is governed through more complex forms of mechanobiological vascular growth rules. Other factors in addition to wall shear stress or more complex WSS rules are likely important in the long-term arterial growth and patterning. Combination in silico/experimental platforms are essential for accelerating our understanding and prediction of consequences from embryonic/fetal cardiovascular occlusions and lay the foundation for noninvasive methods to guide CHD diagnosis and fetal intervention. PMID:25416845

  2. Clinical Study of the Use of the Laser Fluorescence Device DIAGNOdent for Detection of Occlusal Caries in Children

    Microsoft Academic Search

    V. Anttonen; L. Seppä; H. Hausen

    2003-01-01

    Diagnosis of non-cavitated occlusal caries is generally considered problematic. The aim of this study was to evaluate the utility of the laser fluorescence device DIAGNOdent as part of routine dental check-ups in children. A total of 613 occlusal surfaces on permanent molars and 436 surfaces on primary molars in children aged 7–8 (n = 55) and 13–14 years (n =

  3. Effect of Prolonged Occlusion on the Microbial Flora, pH, Carbon Dioxide and Transepidermal Water Loss on Human Skin

    Microsoft Academic Search

    Raza Aly; Charlene Shirley; Bob Cunico; Howard I. Maibach

    1978-01-01

    The effects of prolonged occlusion on the normal microbial skin flora, pH, transepidermal water loss (TEWL) and carbon dioxide emission rate (CDER) were studied. The total average counts before occlusion were 1.8 × 102\\/cm2 and increased to 4.5 × 10&6 on day 5. The highest counts were noted on day 4 (9.8 × 10&7\\/cm2). The composition changed: controls comprised of

  4. Retinal artery occlusions in children.

    PubMed

    Dharmasena, Aruna; Wallis, Simon

    2014-01-01

    The purpose of this study is to present a case of RAO in a 13 year old girl with a preceding history of hyperextension of the neck at her hairdressers for a long duration and use of her mobile phone handset resting it against the side of her neck presumably exerting some pressure on carotids during the same time. Materials and methods of this study was reported as case report and review of literature. A 13 year-old girl presented with the left supero-nasal scotoma due to an inferior temporal branch retinal artery occlusion (BRAO). She underwent extensive investigations and no underlying cause was discovered. She gave a history of cervical extension over a long period of time while having the hair coloured twice in the preceding week. She also mentioned that she was using her mobile phone more or less continuously during both these occasions keeping it against her neck. Given the above history it is possible that the pressure on the ipsilateral carotid arteries or the prolong neck extension may have been responsible for the formation of a platelet embolus resulting in the BRAO. In conclusion, although cerebro-vascular accidents due to 'beauty parlor stroke syndrome' (JAMA 269:2085-2086, 1993) have been reported previously it has not been reported in children to our knowledge. On the other hand, 'beauty parlor stroke syndrome' occurs due to a dissection of the vertebral arteries or due to mechanical compression of the vertebral arteries during the prolonged hyperextension of the neck. The central retinal artery originates from the internal carotid circulation and it is highly unlikely for an embolus to enter the retinal circulation from the vertebral arteries. Therefore, the authors favour the possibility that the compulsive use of a mobile phone exerting pressure on the carotid arteries for a long time may have led to the formation of an embolus and subsequent RAO in this case. PMID:23440575

  5. Pelvic venoablation with ethanol for the treatment of erectile dysfunction due to veno-occlusive dysfunction

    Microsoft Academic Search

    Yoshiji Miwa; Rikiya Shioyama; Yasuhiko Itou; Hiroshi Kanamaru; Kenichiro Okada

    2001-01-01

    Objectives. To perform pelvic venoablation with ethanol injection into the deep dorsal vein for the treatment of 10 patients with venogenic erectile dysfunction. This procedure was easily performed without any selective embolization technique. The efficacy and safety of this technique are discussed.Methods. A total of 10 patients with veno-occlusive dysfunction, severe enough to make vaginal insertion impossible, underwent pelvic venoablation

  6. Occlusion issues in early Renaissance art

    PubMed Central

    Gillam, Barbara

    2011-01-01

    Early Renaissance painters innovatively attempted to depict realistic three-dimensional scenes. A major problem was to produce the impression of overlap for surfaces that occlude one another in the scene but are adjoined in the picture plane. Much has been written about perspective in art but little about occlusion. Here I examine some of the strategies for depicting occlusion used by early Renaissance painters in relation to ecological considerations and perceptual research. Perceived surface overlap is often achieved by implementing the principle that an occluding surface occludes anything behind it, so that occlusion perception is enhanced by a lack of relationship of occluding contour to occluded contours. Some well-known figure-ground principles are also commonly used to stratify adjoined figures. Global factors that assist this stratification include the placement of figures on a ground plane, a high viewpoint, and figure grouping. Artists of this period seem to have differed on whether to occlude faces and heads, often carefully avoiding doing so. Halos were either eliminated selectively or placed oddly to avoid such occlusions. Finally, I argue that the marked intransitivity in occlusion by architecture in the paintings of Duccio can be related to the issue of perceptual versus cognitive influences on the visual impact of paintings. PMID:23145262

  7. Determinants of hemorrhagic infarcts. Histologic observations from experiments involving coronary occlusion, coronary reperfusion, and reocclusion.

    PubMed Central

    Garcia-Dorado, D.; Théroux, P.; Solares, J.; Alonso, J.; Fernandez-Avilés, F.; Elizaga, J.; Soriano, J.; Botas, J.; Munoz, R.

    1990-01-01

    Quantification of intramyocardial hemorrhage was performed in 69 pigs submitted to various protocols of coronary artery occlusion and reperfusion. The study groups include 1) permanent occlusion; 2) reperfusion after periods of coronary occlusion of 30, 45, 60, 90, and 120 minutes; 3) reperfusion with diltiazem and with 4) methoxamine after a 60-minute occlusion period; and 5) permanent reocclusion after a 30-minute period of reperfusion. Red blood cell counts were directly assessed by visual examination of histologic slices of myocardium and in a subgroup of animals by counts of red blood cells labeled with 99m-technetium pertechnetate. Hemorrhage occurs in infarcts reperfused after a duration of 45 minutes or more of coronary occlusion and after a period of reperfusion maintained for at least 30 minutes. Red blood cell counts were maximal in the mid portions of transmural sections of the infarcts, with decreasing values toward epicardium and endocardium. Diltiazem decreased total red blood cell counts, whereas methoxamine increased it and also caused subendocardial hemorrhage. The most powerful predictors of the severity of hemorrhage after sustained reperfusion were infarct size and higher blood pressure. Images Figure 3 Figure 3 PMID:2386198

  8. The effect of chronic formaldehyde exposure on the hippocampus in chronic cerebral hypoperfusion rat model

    Microsoft Academic Search

    Ren-Xiu Bian; Jae-Young Han; Jung-Kook Kim; In-Sung Choi; Sam-Gyu Lee; Jong-Seong Park; Young-Do Jung

    2012-01-01

    The aim of this study was to evaluate the effect of chronic formaldehyde (FA) exposure on the hippocampus in the chronic cerebral hypoperfusion rat model. Seventy-two male Sprague-Dawley rats were randomly divided into four groups: (A) sham-operated bilateral common carotid artery occlusion (BCCAO) with room air inhalation, (B) BCCAO with room air inhalation, (C) sham-operated BCCAO with FA inhalation at

  9. Medical treatment of retinal vein occlusions.

    PubMed

    Parodi, Maurizio Battaglia

    2004-01-01

    The medical treatment of retinal vein occlusion (RVO) is comprised of three main stages: identification and therapy of the detectable risk factors, specific treatment aimed at the occlusive form and treatment of RVO complications. Even though the possible medical management of RVO includes several treatments, the most interesting approaches have been: anticoagulant/antiaggregating agents, troxerutin, corticosteroid, fibrinolytic/thrombolytic agents, and hemodilution. Overall, the medical approach to RVO is still awkward and unsatisfactory. Randomized clinical trials are needed to assess the degree of efficacy of the medical treatment of the specific forms of RVO. PMID:15590533

  10. Meta-analysis of plasma homocysteine, serum folate, serum vitamin B 12, and thermolabile MTHFR genotype as risk factors for retinal vascular occlusive disease

    Microsoft Academic Search

    Mark T Cahill; Sandra S Stinnett; Sharon Fekrat

    2003-01-01

    PurposeTo assess the role of plasma total homocysteine (tHcy) levels, serum folate and vitamin B12levels, and homozygosity for the thermolabile methylenetetrahydrofolate reductase genotype (TT) as risk factors for retinal vascular occlusive disease.

  11. Failure of aneurysm occlusion by flow diverter: a role for surgical bypass and parent artery occlusion.

    PubMed

    Mattingly, Thomas; Van Adel, Brian; Dyer, Erin; Lopez-Ojeda, Pablo; Pelz, David M; Lownie, Stephen P; Marotta, Thomas; Boulton, Melfort

    2015-04-01

    Flow diverters represent a paradigm shift in the treatment of aneurysms. However, unusual and poorly understood complications are being reported. We present a case of a giant internal carotid artery terminus aneurysm treated with flow diversion that progressively and symptomatically enlarged despite a reduction in the filling portion. Complete occlusion of the aneurysm and reduction in mass effect occurred through superficial temporal artery- middle cerebral artery bypass and parent artery occlusion. Incomplete aneurysm occlusion following flow diversion has been reported, but mechanisms and predisposing factors are speculative and definitive solutions have not been described. This case illustrates a potential solution. PMID:24627263

  12. Chronic obstructive pulmonary disease symptom effects of long-term cumulative exposure to ambient levels of total suspended particulates and sulfur dioxide in California Seventh-Day Adventist residents

    SciTech Connect

    Euler, G.L.; Abbey, D.E.; Magie, A.R.; Hodgkin, J.E.

    1987-07-01

    Risk of chronic obstructive pulmonary disease symptoms due to long-term exposure to ambient levels of total suspended particulates (TSP) and sulfur dioxide (SO/sub 2/) symptoms was ascertained using the National Heart, Lung, and Blood Institute (NHLBI) respiratory symptoms questionnaire on 7445 Seventh-Day Adventists. They were non-smokers, at least 25 yr of age, and had lived 11 yr or more in areas ranging from high to low photochemical air pollution in California. Participant cumulative exposures to each pollutant in excess of four thresholds were estimated using monthly residence zip code histories and interpolated dosages from state air monitoring stations. These pollutant thresholds were entered individually and in combination in multiple logistic regression analyses with eight covariables including passive smoking. Statistically significant associations with chronic symptoms were seen for: SO/sub 2/ exposure above 4 pphm (104 mcg/m3), (p = .03), relative risk 1.18 for 500 hr/yr of exposure; and for total suspended particulates (TSP) above 200 mcg/m3, (p less than .00001), relative risk of 1.22 for 750 hr/yr.

  13. Detecting Occlusion and Camouflage during Visual T. Chandesa

    E-print Network

    Bargiela, Andrzej

    Detecting Occlusion and Camouflage during Visual Tracking T. Chandesa School of Computer Science algorithms exist, occlusion and camouflage remain a common problem. These can cause a tracker to become on the detection of occlusion and camouflage during particle filter-based tracking. We use a Gaussian Mixture Model

  14. Functional Patterns of Molar Occlusion in Platyrrhine Primates

    E-print Network

    Rosenberger, Alfred H.

    Functional Patterns of Molar Occlusion in Platyrrhine Primates ALFRED L ROSENBERGERZ AND WARREN G mechanics . Dentition Molars . Occlusion Tooth wear Platyrrhine. ABSTRACT Mechanico-functional features are adapted to loading foods under relatively high occlusal pressure; those of Pithe- cia and Cebus, under

  15. Boundary Fragment Matching Articulated Pose Under Occlusion

    E-print Network

    Howe, Nicholas

    Silhouette-based Body-part Hypotheses Kwatra, Bobick, & Johnson, CVPR 2001 #12;Occlusion Ruins Everything ­ Efficient: best fragment matching approximated via EMD embedding [5] Assume for the moment that we knowAssume for the moment that we know which parts of the boundary arewhich parts of the boundary are ""realreal"" #12

  16. Vertebrobasilar Occlusive Disease: Review of Selected Aspects

    Microsoft Academic Search

    Louis R. Caplan; Barbara Tettenborn

    1992-01-01

    The traditional teaching that embolism is a rare stroke mechanism in the posterior circulation has little basis in fact. We reviewed past reports of patients with documented arterial occlusions at various vertebrobasilar sites to seek both potential recipient and donor sites for embolism. We have prospectively collected over 100 patients with brainstem and cerebellar infarcts who have been intensively studied

  17. Dynamics of Dental Occlusion in Baboons

    Microsoft Academic Search

    Paul P. Zanowiak

    1974-01-01

    An investigation of the dynamics of dental occlusion in baboons showed mandibular movement to be rotary and cyclic and to include lateral motion. The path of motion was related directly to the dental articulation, and it was not restricted by the overlapping canines, indicating a major premise of the cuspid-rise theory is invalid.

  18. Dental occlusion and posture: an overview

    Microsoft Academic Search

    Ambra Michelotti; Gerarda Buonocore; Paolo Manzo; Gioacchino Pellegrino; Mauro Farella

    2011-01-01

    ObjectivesIn recent decades, it has been suggested that disorders of the masticatory system such as malocclusions, can influence whole body posture. A growing number of patients are seeking concomitant treatment for dental malocclusions and postural disorders. The aim of this overview is to critically analyze the relationship between dental occlusion and posture.

  19. The effects of salivas on occlusal forces.

    PubMed

    McCrea, E S; Katona, T R; Eckert, G J

    2015-05-01

    Contacting surfaces of opposing teeth produce friction that, when altered, changes the contact force direction and/or magnitude. As friction can be influenced by several factors, including lubrication and the contacting materials, the aim of this study was to measure the occlusal load alterations experienced by teeth with the introduction of different salivas and dental restorative materials. Pairs of molar teeth were set into occlusion with a weighted maxillary tooth mounted onto a vertical sliding assembly and the mandibular tooth supported by a load cell. The load components on the mandibular tooth were measured with three opposing pairs of dental restorative materials (plastic denture, all-ceramic and stainless steel), four (human and three artificial) salivas and 16 occlusal configurations. All lateral force component measurements were significantly different (P < 0·0001) from the dry (control) surface regardless of the crown material or occlusal configuration, while the effects of the artificial salivas compared to each other and to human saliva depended on the crown material. PMID:25484034

  20. Chronic Bronchitis

    MedlinePLUS

    ... chronic. Chronic bronchitis is one type of COPD (chronic obstructive pulmonary disease). The inflamed bronchi produce a lot of mucus. This leads to cough and difficulty getting air in and out of the ... cause chronic bronchitis. Treatment will help your symptoms, but chronic ...

  1. The effects of ablations in the central nervous system on arrhythmias induced by coronary occlusion in the rat.

    PubMed Central

    Curtis, M. J.; Macleod, B. A.; Walker, M. J.

    1985-01-01

    The role of the central nervous system (CNS) in arrhythmogenesis in the 4 h period following occlusion of a coronary artery was investigated in rats by use of CNS ablations and other procedures. Ablations in the CNS included pithing, spinalization and decerebration combined with acute and chronic surgical preparation and noradrenaline/adrenaline infusions. All procedures involving acute surgery reduced the incidence and severity of the arrhythmias induced by occlusion. Such reductions were most marked in the second (0.5-4 h post-occlusion) arrhythmic period. The observed reductions in arrhythmias could not be explained in terms of involvement of the CNS or adrenoceptor activation. When circulating leucocytes, platelets and serum potassium were measured in a group of pithed rats before and after occlusion, reduced levels (20-50%) of both leucocytes and platelets occurred while serum potassium levels rose by 50-100%. Arrhythmias following coronary occlusion may depend in part on factors in the blood such as leucocytes, platelets and serum potassium and these factors may be altered by acute surgery. PMID:4063585

  2. Occlusion handling in videos object tracking: A survey

    NASA Astrophysics Data System (ADS)

    Lee, B. Y.; Liew, L. H.; Cheah, W. S.; Wang, Y. C.

    2014-02-01

    Object tracking in video has been an active research for decades. This interest is motivated by numerous applications, such as surveillance, human-computer interaction, and sports event monitoring. Many challenges regarding tracking objects remain, this can arise due to abrupt object motion, changing appearance patterns of objects and the scene, non-rigid object structures and most significancly occlusion of tracked object (be it object-to-object or object-to-scene occlusions). Generally, occlusion in object tracking occurs under three situations: self-occlusion, inter-object occlusion by background scene structure. Self-occlusion most frequently arises while tracking articulated objects when one part of the object occludes another. Inter-object occlusion occurs when two objects being tracked occlude each other whereas occlusion by the background occurs when a structure in the background occludes the tracked objects. Typically, tracking methods handle occlusion by modelling the object motion using linear and non-linear dynamic models. The derived models will be used to continuously predicting the object location when a tracked object is occluded until the object reappears. Examples of these methods are Kalman filtering and Particle filtering trackers. Researchers have also utilised other features to resolved occlusion, for example, silhouette projections, colour histogram and optical flow. We will present some results from a previously conducted experiment when tracking single object using Kalman filter, Particle filter and Mean Shift trackers under various occlusion situations. We will also review various other occlusion handling methods that involved using multiple cameras. In a nutshell, the goal of this paper is to discuss in detail the problem of occlusion in object tracking and review the state of the art occlusion handling methods, classify them into different categories, and identify new trends. Moreover, we discuss the important issues related to occlusion handling including the use of appropriate selection of motion models, image features and use of multiple cameras.

  3. Occlusion Handling in Videos Object Tracking: A Survey

    NASA Astrophysics Data System (ADS)

    Lee, B. Y.; Liew, L. H.; Cheah, W. S.; Wang, Y. C.

    2014-02-01

    Object tracking in video has been an active research since for decades. This interest is motivated by numerous applications, such as surveillance, human-computer interaction, and sports event monitoring. Many challenges related to tracking objects still remain, this can arise due to abrupt object motion, changing appearance patterns of objects and the scene, non-rigid object structures and most significant are occlusion of tracked object be it object-to-object or object-to-scene occlusions. Generally, occlusion in object tracking occur under three situations: self-occlusion, inter-object occlusion by background scene structure. Self-occlusion occurs most frequently while tracking articulated objects when one part of the object occludes another. Inter-object occlusion occurs when two objects being tracked occlude each other whereas occlusion by the background occurs when a structure in the background occludes the tracked objects. Typically, tracking methods handle occlusion by modelling the object motion using linear and non-linear dynamic models. The derived models will be used to continuously predicting the object location when a tracked object is occluded until the object reappears. Example of these method are Kalman filtering and Particle filtering trackers. Researchers have also utilised other features to resolved occlusion, for example, silhouette projections, colour histogram and optical flow. We will present some result from a previously conducted experiment when tracking single object using Kalman filter, Particle filter and Mean Shift trackers under various occlusion situation in this paper. We will also review various other occlusion handling methods that involved using multiple cameras. In a nutshell, the goal of this paper is to discuss in detail the problem of occlusion in object tracking and review the state of the art occlusion handling methods, classify them into different categories, and identify new trends. Moreover, we discuss the important issues related to occlusion handling including the use of appropriate selection of motion models, image features and use of multiple cameras.

  4. Occlusal Status among 12-16 Year-Old School Children in Riyadh, Saudi Arabia

    PubMed Central

    Asiry, Moshabab A

    2015-01-01

    Background: Identifying occlusal status in a particular population will be valuable in planning the appropriate preventive and treatment programs. The purpose of this study was to assess the status of occlusion among school children in Riyadh, Saudi Arabia. Materials and Methods: This study was conducted at Riyadh, Saudi Arabia from September 2012 to June 2013. A total of 1825 Saudis (1007 males and 818 females) of 12-16 years old were randomly selected from 20 schools in different areas of Riyadh city to determine the status of their occlusion. The examiners assessed molar and canine relationships, spacing and crowding, overjet, overbite, anterior and posterior cross bite. These occlusal parameters were examined by two experienced examiners using a mouth mirror, small light source and calibrated fiber ruler. Results: About 60.11% of Saudis presented with Class I molar relationship while 7.12% and 10.13% of the subjects had Class II and III molar relationship, respectively. The most prevalent canine relationship was Class I (54.13%), followed by Class II (12.4%) and Class III (11.2). Normal overjet and overbite were observed in 76% and 67% of the sample, respectively. The prevalence of malocclusion traits were crowding (45.4%), Spacing (26.9%), excessive over jet (16.4%), posterior cross bite (8.9%), anterior open bite (8.4%) and excessive overbite (6.68%). No statistically significant differences were found between the genders about the prevalence of any occlusion traits (P > 0.05). Conclusion: Class I molar relationship, normal overbite, and normal overjet were dominant features among Saudis. Crowding was the most prevalent malocclusion trait, followed by spacing. These findings will help in understanding the occlusion status in order to plan for prevention and treatment of malocclusion in Riyadh city. PMID:26028897

  5. Branch Retinal Artery Occlusion following Dental Extraction

    PubMed Central

    O?urel, Tevfik; Onaran, Zafer; O?urel, Reyhan; Örnek, Nurgül; Büyüktortop Gökç?nar, Nesrin; Örnek, Kemal

    2014-01-01

    Aim. To describe a case of branch retinal artery occlusion following dental extraction and to point out the ophthalmic complications of dental procedures to ophthalmologists and dentists. Case. A 51-year-old woman was referred to our clinic with painless sudden visual loss in her left eye after tooth extraction two days ago. In her left eye the best corrected visual acuity was 6/30 and fundus examination revealed peripapillary flame-shaped hemorrhages and pale retina in the upper temporal arcuate. The right eye examination was unremarkable. Conclusion. Dental procedures can lead to miscellaneous ophthalmic complications possibly due to the close proximity of the anatomic structures. Retinal arterial occlusion is a rare but serious cause of permanent visual loss among these dental procedures where the exact pathologic mechanism is still obscure. PMID:25580327

  6. Chronic thromboembolic pulmonary hypertension.

    PubMed

    Hoeper, Marius M; Madani, Michael M; Nakanishi, Norifumi; Meyer, Bernhard; Cebotari, Serghei; Rubin, Lewis J

    2014-07-01

    Chronic thromboembolic pulmonary hypertension (CTEPH) is a rare but debilitating and life-threatening complication of acute pulmonary embolism. CTEPH results from persistent obstruction of pulmonary arteries and progressive vascular remodelling. Not all patients presenting with CTEPH have a history of clinically overt pulmonary embolism. The diagnostic work-up to detect or rule out CTEPH should include ventilation-perfusion scintigraphy, which has high sensitivity and a negative predictive value of nearly 100%. CT angiography usually reveals typical features of CTEPH, including mosaic perfusion, part or complete occlusion of pulmonary arteries, and intraluminal bands and webs. Patients with suspected CTEPH should be referred to a specialist centre for right-heart catheterisation and pulmonary angiography. Surgical pulmonary endarterectomy remains the treatment of choice for CTEPH and is associated with excellent long-term results and a high probability of cure. For patients with inoperable CTEPH, various medical and interventional therapies are being developed. PMID:24898750

  7. Tracking targets through occlusions in outdoor videos

    NASA Astrophysics Data System (ADS)

    Mao, Hongwei; Yang, Chenhui; Abousleman, Glen P.; Si, Jennie

    2011-05-01

    In real-world outdoor video, moving targets such as vehicles and people may be partially or fully occluded by background objects such as buildings and trees, which makes tracking them continuously a very challenging task. In the present work, we present a system to address the problem of tracking targets through occlusions in a motion-based target detection and tracking framework. For an existing track that is fully occluded, a Kalman filter is applied to predict the target's current position based upon its previous locations. However, the prediction may drift from the target's true trajectory due to accumulated prediction errors, especially when the occlusion is of long duration. To address this problem, tracks that have disappeared are checked with an extra data association procedure that evaluates the potential association between the track and the new detections, which could be a previously tracked target that is just coming out of occlusion. Another issue that arises with motion-based tracking is that the algorithm may consider the visible part of a partially occluded target as the entire target region. This is problematic because an inaccurate target motion trajectory model will be built, causing the Kalman filter to generate inaccurate target position predictions, which can yield a divergence between the track and the true target trajectory. Accordingly, we present a method that provides reasonable estimates of the partially-occluded target centers. Experimental results conducted on real-world unmanned air vehicle (UAV) video sequences demonstrate that the proposed system significantly improves the track continuity in various occlusion scenarios.

  8. Endovascular Repair of Aortoiliac Occlusive Disease

    Microsoft Academic Search

    Michael L. Marin; Frank J. Veith; Luis A. Sanchez; Jacob Cynamon; Ross T. Lyon; William D. Suggs; Curtis W. Bakal; Richard E. Parsons

    1996-01-01

    . Occlusive disease of the aorta and iliac and femoral arteries may lead to limb-threatening ischemia when multiple\\u000a levels of disease are present. The combined treatment of severe aortoiliac and infrainguinal disease using standard techniques\\u000a may be hazardous or contraindicated in patients with multiple, previous reconstructions or severe co-morbid medical illnesses.\\u000a This report summarizes the technical feasibility and early results

  9. Lichen sclerosus: role of occlusion of the genital skin in the pathogenesis.

    PubMed

    Gupta, Somesh; Malhotra, Amit Kumar; Ajith, C

    2010-01-01

    Lichen sclerosus (LS) is a chronic inflammatory skin disease, which most commonly involves the anogenital region. The etiology of LS is obscure, but genetic susceptibility, autoimmune mechanisms, infective agents like human papillomavirus and spirochaetes, and Koebner phenomenon has been postulated as causative factors. We report our observation in 6 patients (3 males and 3 females) with histologically proven lichen sclerosus that showed relative sparing of the uncovered areas of the genitals, thereby suggesting that the occlusion of the genital skin may be playing a greater role in the causation of LS than is currently thought, in both sexes. PMID:20061733

  10. Interventional Treatment of Mesenteric Venous Occlusion

    PubMed Central

    Wichman, Heather J.; Cwikiel, Wojciech; Keussen, Inger

    2014-01-01

    Summary Background Mesenteric venous thrombus may be an incidental finding during imaging studies and asymptomatic patients are treated conservatively or with anticoagulant therapy only. Patients with symptomatic acute thrombosis causing bowel ischemia require urgent treatment, which frequently includes extensive surgery. Interventional treatment may be an alternative. Purpose: To present results of interventional treatment in patients with symptomatic occlusion of the mesenteric veins. Material/Methods Eight patients, four men and four women aged 24–74 years (mean 53 years) were treated due to symptomatic portomesenteric venous occlusion of thrombotic origin. Transhepatic (n=5), trans-splenic (n=2), and transjugular (n=4) accesses were used. Patients were treated with mechanical thrombus fragmentation (n=4), pharmacological thrombolysis (n=3) and stent placement (n=8). Additional transjugular intrahepatic portosystemic shunt (TIPS) was created to facilitate the outflow from the treated veins (n=4). Results The majority of the patients required combination of different treatment methods. Resolution of symptoms with initial clinical success was achieved in seven of the eight patients, and one patient died the day after the procedure due to sepsis. Two other patients had procedure-related complications; one of them required embolization. Two patients had documented long-term clinical success with patent stents and no symptoms at one year following intervention. Conclusions Endovascular treatment of portomesenteric occlusion in patients with acute symptomatology showed good short-term clinical success rate. PMID:25089163

  11. Nasoduodenal feeding tubes: prevention of occlusion.

    PubMed

    Scanlan, M; Frisch, S

    1992-10-01

    Blockage of nasoduodenal feeding tubes is costly in terms of materials and nursing time, and traumatic to the neuroscience patient. A laboratory experimental study explored ways to decrease obstruction of small bore nasoduodenal feeding tubes when medications are given concurrently with continuous tube feeding. The first part of the study examined type and form of 4 medications in relation to frequency and timing of tube blockage. Trimethoprim sulfamethoxazole (Septra) in dissolved pill form blocked tubes most frequently (F10,77 = 10.333, p < .001) and in the shortest time (F10,77 = 10.534, p < .001). The second part of the study examined different irrigation methods. Irrigation before and after administration of medication and irrigation after medication administration only were significantly better than no irrigation in preventing blockage, both in terms of number of occlusions (F2,87 = 5.486, p < .01) and time to occlusion (F2,87 = 4.556, p < .02). The fact the study was performed in vitro rather than in vivo was a limiting factor. However, results of the study suggest trimethoprim sulfamethoxazole forms occlusions, especially in dissolved form. Elixir of this medication should probably be used whenever available. This study also found that irrigating the tube before and after administration of medications was the most effective of the 3 options examined. PMID:1402149

  12. Elevated total iron-binding capacity as a predictor of response to deferasirox therapy in the setting of chronic iron overload.

    PubMed

    Watanabe, Junichi; Sato, Ken; Horiuchi, Toshikatsu; Kato, Shoichiro; Hikota, Reina; Maekawa, Takaaki; Yamamura, Takeshi; Kobayashi, Ayako; Osawa, Yukiko; Kobayashi, Shinichi; Kimura, Fumihiko

    2014-09-01

    It is difficult to predict the efficacy of deferasirox (DFX) as its pharmacokinetics varies among patients. The area under the curve (AUC) is reportedly useful for determining adequate DFX dosage; however, serum concentration measurements are often challenging. Effective DFX dosage is thus defined by assessing the efficacy of this agent in clinical practice. To analyze a predictive response marker to DFX therapy for use in adjusting the effective dosage during the early treatment phase, we retrospectively evaluated 39 DFX-treated patients. We defined response as a >40 % decrease in serum ferritin concentration from the pretreatment level. A maximum elevation of the total iron-binding capacity (TIBC) correlated with response in a multivariate analysis of iron metabolic markers (R (2) = 0.37, p < 0.001). A receiver operating characteristic curve analysis revealed that TIBC elevation had an AUC of 0.85 (p < 0.001) and the optimal cut-off value of TIBC elevation was 150 µg/dl. TIBC elevation of >150 µg/dl is a favorable predictor of effective ferritin reduction in DFX therapy (hazard ratio 29.6, 95 % confidence interval 4.8-183.6; p < 0.001). DFX therapy with TIBC monitoring may enable the determination of the minimum effective DFX dosage. PMID:24986748

  13. A rare aberrant distal branch preventing complete internal carotid artery occlusion.

    PubMed

    Chang, K H; Cotter, J; McGreal, G T

    2015-01-01

    A 72-year-old man presented with a 3-day history of recurrent transient ischaemic attacks comprising slurred speech, left arm weakness and paresthesia. Carotid Doppler revealed total occlusion of the right internal carotid artery (ICA). Computed tomography angiography demonstrated occlusion of the proximal right ICA over a length of 1.5 cm. The ICA distal to the occlusion was entirely normal. In view of the normal distal ICA, a decision was made to proceed with surgical exploration and right carotid endarterectomy, on the basis that there must have been some flow through the lesion. Intra-operatively, there was an extensive plaque in the carotid bulb and proximal ICA causing 80-90% stenosis. Fresh thrombus completed the occlusion. An aberrant branch of the ICA was identified distal to the plaque, the backflow through which maintained patency of the distal ICA. A standard endarterectomy was performed. The patient recovered uneventfully, being discharged on the second post-operative day. PMID:26070479

  14. A rare aberrant distal branch preventing complete internal carotid artery occlusion

    PubMed Central

    Chang, K.H.; Cotter, J.; McGreal, G.T.

    2015-01-01

    A 72-year-old man presented with a 3-day history of recurrent transient ischaemic attacks comprising slurred speech, left arm weakness and paresthesia. Carotid Doppler revealed total occlusion of the right internal carotid artery (ICA). Computed tomography angiography demonstrated occlusion of the proximal right ICA over a length of 1.5 cm. The ICA distal to the occlusion was entirely normal. In view of the normal distal ICA, a decision was made to proceed with surgical exploration and right carotid endarterectomy, on the basis that there must have been some flow through the lesion. Intra-operatively, there was an extensive plaque in the carotid bulb and proximal ICA causing 80–90% stenosis. Fresh thrombus completed the occlusion. An aberrant branch of the ICA was identified distal to the plaque, the backflow through which maintained patency of the distal ICA. A standard endarterectomy was performed. The patient recovered uneventfully, being discharged on the second post-operative day. PMID:26070479

  15. The inspiratory capacity/total lung capacity ratio as a predictor of survival in an emphysematous phenotype of chronic obstructive pulmonary disease

    PubMed Central

    French, Aimee; Balfe, David; Mirocha, James M; Falk, Jeremy A; Mosenifar, Zab

    2015-01-01

    Background Forced expiratory volume in 1 second (FEV1) grades severity of COPD and predicts survival. We hypothesize that the inspiratory capacity/total lung capacity (IC/TLC) ratio, a sensitive measure of static lung hyperinflation, may have a significant association with survival in an emphysematous phenotype of COPD. Objectives To access the association between IC/TLC and survival in an emphysematous phenotype of COPD. Methods We performed a retrospective analysis of a large pulmonary function (PF) database with 39,050 entries, from April 1978 to October 2009. Emphysematous COPD was defined as reduced FEV1/forced vital capacity (FVC), increased TLC, and reduced diffusing capacity of the lungs for carbon monoxide (DLCO; beyond 95% confidence intervals [CIs]). We evaluated the association between survival in emphysematous COPD patients and the IC/TLC ratio evaluated both as dichotomous (?25% vs >25%) and continuous predictors. Five hundred and ninety-six patients had reported death dates. Results Univariate analysis revealed that IC/TLC ?25% was a significant predictor of death (hazard ratio [HR]: 2.39, P<0.0001). Median survivals were respectively 4.3 (95% CI: 3.8–4.9) and 11.9 years (95% CI: 10.3–13.2). Multivariable analysis revealed age (HR: 1.19, 95% CI: 1.14–1.24), female sex (HR: 0.69, 95% CI: 0.60–0.83), and IC/TLC ?25% (HR: 1.69, 95% CI: 1.34–2.13) were related to the risk of death. Univariate analysis showed that continuous IC/TLC was associated with death, with an HR of 1.66 (95% CI: 1.52–1.81) for a 10% decrease in IC/TLC. Conclusion Adjusting for age and sex, IC/TLC ?25% is related to increased risk of death, and IC/TLC as a continuum, is a significant predictor of mortality in emphysematous COPD patients.

  16. Recanalization of Acute and Subacute Femoropopliteal Artery Occlusions with the Rotarex Catheter: One Year Follow-up, Single Center Experience

    SciTech Connect

    Duc, Sylvain R., E-mail: Sylvain.duc@balgrist.ch; Schoch, Eric [Kantonsspital Winterthur, Department of Radiology (Switzerland); Pfyffer, Markus; Jenelten, Regula [Section of Angiology, Kantonsspital Winterthur, Department of Internal Medicine (Switzerland); Zollikofer, Christoph L. [Kantonsspital Winterthur, Department of Radiology (Switzerland)

    2005-06-15

    Purpose:To assess the efficacy and safety of a new rotational catheter for percutaneous removal of fresh and organized thrombi in the femoropopliteal artery.Methods:Forty-one limbs in 38 patients (age 56-90 years, mean 75.6 years) with acute, subacute or chronic femoropopliteal occlusions of 1-180 days' duration (mean 31.6 days) were treated with the Rotarex device. The Fontaine stage was mainly IIB (Rutherford 2-3, 22 patients) or III (Rutherford 4, 14 patients). The length of occlusion varied from 2 to 35 cm (mean 13.1 cm). After recanalization percutaneous transluminal angioplasty (PTA) was performed if there was a residual stenosis of >25%. Patients were followed up with color Doppler ultrasound at 48 hr and clinically with Doppler pressures and oscillometry at 3, 6, and 12 months.Results:After an average of two passages with the Rotarex catheter all but two limbs required PTA for residual stenosis >25%. Five patients needed additional stenting. Major complications were one groin hematoma requiring blood transfusion and one arteriovenous fistula spontaneously thrombosing after unsuccessful primary prolonged balloon dilation. Distal embolizations occurred in 10 patients; 6 clinically relevant emboli were aspirated. All occlusions were technically successfully recanalised there were 2 early reocclusions after 1 day and two at 2 weeks. Brachial-ankle indices improved from an average of 0.41 before to 0.93 after recanalization. Primary and secondary patency rates were 62% / 84% after 6 months and 39% / 68% after 1 year. The amputation-free survival at 12 months was 100%.Conclusion:The Rotarex mechanical thrombectomy device is an efficient, quick, easy to handle, and safe tool for the treatment of acute, subacute or even chronic peripheral arterial thromboembolic occlusions. It can be used for short or long occlusions with equal success, provided the obstruction is not heavily calcified and has been safely passed with a guidewire first.

  17. [Mandibular movement and electromyogram investigation of normal occlusion and reversed occlusion before and after correction of over jet].

    PubMed

    Maeda, T

    1989-06-01

    The purpose of this investigation was to understand how the mandibular movement and myofunction in reversed occlusion, approach to normal occlusion after the correction of over jet. The experiment was carried out in 30 normal and 26 reversed occlusion school children patients who were classified into 3 groups by morphological analysis. A K6 diagnostic system was used. It recorded muscle activity of maximum clenching, free way space, path of closure, and the maximum velocity of opening and closing mandibular. And recorded a condylar test at the same time. Reversed occlusion classified 3 groups: upper and lower incisor had improper inclinations (D group, 19%), construction bite possible but recognized back and forth discrepancy between maxilla and mandibular (FS group, 50%), discrepancy larger than FS group and construction bite not possible (S group, 31%). Toward upper forth group indicated 77% and toward upper back group indicated 23% in normal occlusion. As for reversed occlusion the former indicated 92% and the latter indicated 8%. Differences in connection with orthodontic appliance and period of treatment were not so large. Back and forth mandibular movement, as measured by a condylar test, was greater for reversed occlusion than for normal occlusion, but this value tended to decrease after orthodontic treatment. In reversed occlusion, maximum opening, free way space, maximum velocity of opening and closing and muscle activity of rest position didn't show significant difference (p less than 0.05) among each group before and after the correction of over jet. Temporalis and masseter activity of maximum clenching, except temporalis among the D group, approached the values for normal occlusion. In the S group, muscle activity of maximum clenching with a cotton-roll, was lower before treatment, but approached to data in normal occlusion. These results prove that improvement of over jet in reversed occlusion, by ordinary orthodontal diagnosis and treatment plan, quasi-normalizes mandibular movement and muscle activity in reversed occlusion. PMID:2637253

  18. Clobetasol propionate 0.05% under occlusion in the treatment of alopecia totalis\\/universalis

    Microsoft Academic Search

    Antonella Tosti; Bianca Maria Piraccini; Massimiliano Pazzaglia; Colombina Vincenzi

    2003-01-01

    Background: Efficacy of topical steroids in alopecia areata is still discussed. Objective: The purpose of this study was to evaluate the efficacy of clobetasol propionate 0.05% ointment under occlusion in 28 patients with alopecia areata totalis (AT) or AT\\/alopecia universalis. Methods: A total of 28 patients were instructed to apply 2.5 g of clobetasol propionate to the right side of

  19. Hypoplastic left heart syndrome and pulmonary veno-occlusive disease in an infant.

    PubMed

    D'Souza, Marise; Vergales, Jeffrey; Jayakumar, K Anitha

    2013-01-01

    This report describes an infant with heterotaxy syndrome and severe hypoplasia of the left heart who presented with profound cyanosis at birth despite a large patent ductus arteriosus. Pulmonary venous return was difficult to demonstrate by echocardiography. Angiography showed total anomalous pulmonary venous return via a plexus that drained through the paravertebral veins and bilateral superior vena cavae. Autopsy confirmed these findings, and histopathology demonstrated severe occlusive changes within the pulmonary veins. PMID:22961346

  20. Chronic pancreatitis.

    PubMed

    Braganza, Joan M; Lee, Stephen H; McCloy, Rory F; McMahon, Michael J

    2011-04-01

    Chronic pancreatitis is a progressive fibroinflammatory disease that exists in large-duct (often with intraductal calculi) or small-duct form. In many patients this disease results from a complex mix of environmental (eg, alcohol, cigarettes, and occupational chemicals) and genetic factors (eg, mutation in a trypsin-controlling gene or the cystic fibrosis transmembrane conductance regulator); a few patients have hereditary or autoimmune disease. Pain in the form of recurrent attacks of pancreatitis (representing paralysis of apical exocytosis in acinar cells) or constant and disabling pain is usually the main symptom. Management of the pain is mainly empirical, involving potent analgesics, duct drainage by endoscopic or surgical means, and partial or total pancreatectomy. However, steroids rapidly reduce symptoms in patients with autoimmune pancreatitis, and micronutrient therapy to correct electrophilic stress is emerging as a promising treatment in the other patients. Steatorrhoea, diabetes, local complications, and psychosocial issues associated with the disease are additional therapeutic challenges. PMID:21397320

  1. Abnormalities of microcirculation in dentoalveolar complex after direct occlusal restorations

    Microsoft Academic Search

    A. Tsimbalistov; Y. Sosnina; E. Statovskaya

    2010-01-01

    Summary  Nowadays, the role of occlusion in etiology and pathogenesis of the inflammation in periodontal tissues have not still become\\u000a clear and considered as biomechanics and articulation. Physiologically, masticatory pressure stimulates metabolic processes\\u000a in periodontal tissues. Occlusal overloading leads to periodontal damages. The aim of this study is to reveal abnormalities\\u000a of microcirculation in periodontal tissues and pulp after direct occlusal

  2. Dental occlusion: modern concepts and their application in implant prosthodontics

    Microsoft Academic Search

    Gunnar E. Carlsson

    2009-01-01

    The aim of this article was to review the literature on various aspects of occlusion related to implant prosthodontics, using\\u000a PubMed and the Cochrane library. Even if the number of studies on implants and prosthodontics is very large, no randomized\\u000a controlled trials or Cochrane reviews were found on the possible influence of occlusal design or characteristics of occlusion\\u000a on treatment

  3. Bilateral vertebral artery balloon occlusion for giant vertebrobasilar aneurysms

    Microsoft Academic Search

    M. Sluzewski; E. H. Brilstra; W. J. van Rooij; D. Wijnalda; C. A. F. Tulleken; G. J. E. Rinkel

    2001-01-01

    We describe the clinical presentation, radiological and clinical results in six consecutive patients with a giant vertebrobasilar\\u000a aneurysm treated by bilateral vertebral artery balloon occlusion. Five patients presented with headache and signs of brain-stem\\u000a compression and one with subarachnoid haemorrhage. In all patients vertebral artery balloon occlusion was performed. In four,\\u000a this followed successful test occlusion. In one patient, who

  4. The occlusal guard: a simplified technique for fabrication and equilibration.

    PubMed

    Antonelli, John; Hottel, Timothy L; Siegel, Sharon C; Brandt, Robert; Silva, Gladston

    2013-01-01

    Hard occlusal guards have been used effectively to treat myofacial pain originating from parafunctional activities. Also, they can protect the natural dentition when it opposes porcelain restorations, help to evaluate changes in occlusal vertical dimension during full mouth rehabilitation, minimize further tooth loss in patients with abfraction lesions, and redirect occlusal loads more favorably onto dental implant-supported prostheses. A simplified technique is described to fabricate a properly designed wax model of an occlusal guard that can be processed in acrylic in the same manner used to construct a complete denture. PMID:23649575

  5. Genetics Home Reference: Hepatic veno-occlusive disease with immunodeficiency

    MedlinePLUS

    ... Gene Reviews Clinical summary Genetic Testing Registry Genetic testing PubMed Recent literature OMIM Genetic disorder catalog Conditions > Hepatic veno-occlusive disease with immunodeficiency ( ...

  6. Measurement of forearm blood flow by venous occlusion plethysmography: Influence of hand blood flow during sustained and intermittent isometric exercise

    Microsoft Academic Search

    Carole A. Williams; Alexander R. Lind

    1979-01-01

    Summary  The requirement for using an arterial occlusion cuff at the wrist when measuring forearm blood flows by plethysmography was tested on a total of 8 subjects at rest and during and after sustained and intermittent isometric exercise. The contribution of the venous effluent from the hand to the forearm flow during exercise was challenged by immersing the arm in water

  7. Dual-Energy CT Angiography in Peripheral Arterial Occlusive Disease

    SciTech Connect

    Brockmann, Carolin, E-mail: carolin.brockmann@rad.ma.uni-heidelberg.de; Jochum, Susanne; Sadick, Maliha [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany); Huck, Kurt [University of Heidelberg, I. Medical Clinic, Medical Faculty Mannheim (Germany); Ziegler, Peter [University of Heidelberg, Department of Surgery, Medical Faculty Mannheim (Germany); Fink, Christian; Schoenberg, Stefan O.; Diehl, Steffen J. [University of Heidelberg, Department of Clinical Radiology and Nuclear Medicine, Medical Faculty Mannheim (Germany)

    2009-07-15

    We sought to study the accuracy of dual-energy computed tomographic angiography (DE-CTA) for the assessment of symptomatic peripheral arterial occlusive disease of the lower extremity by using the dual-energy bone removal technique compared with a commercially available conventional bone removal tool. Twenty patients underwent selective digital subtraction angiography and DE-CTA of the pelvis and lower extremities. CTA data were postprocessed with two different applications: conventional bone removal and dual-energy bone removal. All data were reconstructed and evaluated as 3D maximum-intensity projections. Time requirements for reconstruction were documented. Sensitivity, specificity, accuracy, and concordance of DE-CTA regarding degree of stenosis and vessel wall calcification were calculated. A total of 359 vascular segments were analyzed. Compared with digital subtraction angiography, sensitivity, specificity, and accuracy, respectively, of CTA was 97.2%, 94.1%, and 94.7% by the dual-energy bone removal technique. The conventional bone removal tool delivered a sensitivity of 77.1%, a specificity of 70.7%, and an accuracy of 72.0%. Best results for both postprocessing methods were achieved in the vascular segments of the upper leg. In severely calcified segments, sensitivity, specificity, and accuracy stayed above 90% by the dual-energy bone removal technique, whereas the conventional bone removal technique showed a substantial decrease of sensitivity, specificity, and accuracy. DE-CTA is a feasible and accurate diagnostic method in the assessment of symptomatic peripheral arterial occlusive disease. Results obtained by DE-CTA are superior to the conventional bone removal technique and less dependent on vessel wall calcifications.

  8. Regional myocardial functional and electrophysiological alterations after brief coronary artery occlusion in conscious dogs.

    PubMed Central

    Heyndrickx, G R; Millard, R W; McRitchie, R J; Maroko, P R; Vatner, S F

    1975-01-01

    The time relationship for recovery of mechanical function, the intramyocardial electrogram and coronary flow after brief periods of regional myocardial ischemia, was studied in conscious dogs. Total left vemtricular (LV) function was assessed with measurements of LV systolic and diastolic pressures, rate of change of LV pressure (dP/dt), and dP/dt/P. Regional LV function was assessed with measurements of regional segment length and velocity of shortening. An implanted hydraulic occluder on either the left anterior descending or circumflex coronary artery was inflated for 5- and 15-min periods on separate days. A 5-min occlusion depressed overall LV function transiently, but just before release of occlusion overall function had nearly returned to control. At this time regional function in the ischemic zone was still depressed to the point of absent shorteining or paradoxical motion during systole and was associated with marked ST segment elevation (+ 10 +/- 2.2 mV) at the site where function was measured. With release of occlusion and reperfusion the intramyocardial electrogram returned to normal within 1 min, and reactive hyperemia subsided by 5-10 min. In contrast to the rapid return to preocclusion levels for coronary flow and the electrogram, regional mechanical function remained depressed for over 3 h. A 15-min coronary occlusion resulted in an even more prolonged (greater than 6 h) derangement of function in the ischemic zone. Thus, brief periods of coronary occlusion result in prolonged impairement of regional myocardial function which could not have been predicted from the rapid return of the electrogram and coronary flow. These observations indicate that brief interruptions of coronary flow result either in a prolonged period of local ischemia or that alterations of mechanical induced by ischemia far outlast the repayment of the oxygen debt. PMID:1159098

  9. Arterial gas occlusions in operating heat pipes

    NASA Technical Reports Server (NTRS)

    Saaski, E. W.

    1975-01-01

    The effect of noncondensable gases on high performance arterial heat pipes has been investigated both analytically and experimentally. Models have been generated which characterize the dissolution of gases in condensate and the diffusional loss of dissolved gases from condensate in arterial flow. These processes, and others, have been used to postulate stability criteria for arterial heat pipes. Experimental observations of gas occlusions were made using a stainless steel heat pipe equipped with viewing ports, and the working fluids methanol and ammonia with the gas additives helium, argon, and xenon. Observations were related to gas transport models.

  10. Chronic pancreatitis

    MedlinePLUS

    Chronic pancreatitis is inflammation of the pancreas that does not heal or improve, gets worse over time, and leads ... abuse over many years. Repeated episodes of acute pancreatitis can lead to chronic pancreatitis. Genetics may be ...

  11. The occlusal appliance effect on myofascial pain.

    PubMed

    Villalón, Pablo; Arzola, Juan Francisco; Valdivia, José; Fresno, María Javiera; Santander, Hugo; Gutiérrez, Mario Felipe; Miralles, Rodolfo

    2013-04-01

    There are limited studies about the effects of occlusal appliance (OA) after three months of use. This study aimed to compare myofascial pain (MP) according to RDC/TMD, craniocervical relationships (CR) and masseter and temporalis bilateral electromyographic (EMG) activity, before and after three months of occlusal appliance use. Nineteen patients participated in this study. Cephalometric and RDC/TMD diagnostics were performed previously (baseline) and at the end of the study period (three months). EMG recordings at clinical mandibular rest position (MRP), during swallowing of saliva (SW) and during maximum voluntary clenching (MVC) were performed as follows: after one hour of use of an OA; after three months of using the OA for a minimum of 16 hours each day; and immediately after removal from the mouth. MP was relieved in all patients at the end of the study period. CR did not change significantly between baseline and after removal of the OA at the end of the study period. EMG activity during MRP, SW, and MVC decreased in both muscles after one hour using the OA and maintained the same level for the three-month period. When comparing baseline versus final EMG activity without OA, a significant decrease was only observed in the masseter muscle. The results observed in the present study are relevant to clinicians because they imply that the therapeutic effect of OA does not significantly affect the homeostasis of the craniocervical system. PMID:23795397

  12. Occlusion Handling Based on Particle Filter in Surveillance System

    Microsoft Academic Search

    Xinting Pan; Xiaobo Chen; Aidong Men

    2010-01-01

    Object tracking with occlusion handling is a challenging problem in intelligent video surveillance system. Among various tracking algorithms, particle filter (PF) is a robust and accurate one for different applications. In this paper, a new approach based on particle filter is presented for tracking object accurately and steadily when the target encountering occlusion in video sequences. First, the object pixels

  13. Dental occlusion modifies gaze and posture stabilization in human subjects

    Microsoft Academic Search

    Pierre Gangloff; Jean-Paul Louis; Philippe P Perrin

    2000-01-01

    Repercussion of dental occlusion was tested upon postural and gaze stabilization, the latter with a visuo-motor task evaluated by shooting performances. Eighteen permit holders shooters and 18 controls were enrolled in this study. Postural control was evaluated in both groups according to four mandibular positions imposed by interocclusal splints: (i) intercuspal occlusion (IO), (ii) centric relation (CR), (iii) physiological side

  14. Effects of Changing Body Position on Dental Occlusion

    Microsoft Academic Search

    Lewis F. Mc Lean; Henry S. Brenman; M. G. F. Friedman

    1973-01-01

    Graded changes in body position produced no noticeable changes in wax registrations of dental contact patterns resulting from voluntary jaw closure. Occlusal contact patterns that resulted from electrically stimulated jaw closures indicated an increase in closing force and a mesial shift of prime occlusal contact points as the body was raised to an upright position.

  15. Using Occlusion Calculi to Interpret Digital Images David Randell1

    E-print Network

    Witkowski, Mark

    ] with which to interpret 3D convex bodies in terms of their projected images. We wish to examine to whatUsing Occlusion Calculi to Interpret Digital Images David Randell1 and Mark Witkowski1 Abstract. This paper reports on an investigation using occlusion calculi to interpret digital images. Using a minimal

  16. Occlusion Detection by Temporal Integration of Optical Flow

    E-print Network

    Soatto, Stefano

    estimating the flow from a single frame­, The authors are with UCLA VisionLab, University of California, Los1 Occlusion Detection by Temporal Integration of Optical Flow Virginia Estellers, Stefano Soatto Abstract--Occlusions become apparent as failing regions in optical-flow models when integrated over time

  17. Cardiovascular reflexes controlling regional sympathetic outflow during coronary artery occlusion

    Microsoft Academic Search

    R. Kullmann

    1982-01-01

    Summary In anesthetized rabbits, sympathetic activity was recorded in efferents to the skin of the ear (ESA), to the hindlimb muscles (MSA), splanchnic region (SSA), adrenals (ASA), and kidneys (KSA) in response to occlusion of the left circumflex coronary artery. Coronary occlusion caused an average decrease of mean arterial blood pressure by 18%. MSA and SSA increased, ESA decreased, and

  18. The Soft Shadow Occlusion Camera University of Iowa

    E-print Network

    Wyman, Chris

    The Soft Shadow Occlusion Camera Qi Mo University of Iowa qmo@cs.uiowa.edu Voicu Popescu Purdue soft shadow algorithm based on a variant of the depth discontinuity oc- clusion camera, a non-pinhole camera with rays that reach around blockers to sample normally hidden surfaces. Our soft shadow occlusion

  19. The Effect of Occlusion on Motion Integration in Infants

    ERIC Educational Resources Information Center

    Otsuka, Yumiko; Konishi, Yukuo; Kanazawa, So; Yamaguchi, Masami K.

    2009-01-01

    Previous psychophysical studies have shown that the adult human visual system makes use of form information such as occlusion to determine whether to integrate or segregate local motion signals (J. McDermott, Y. Weiss, & E. H. Adelson, 2001). Using the displays developed by McDermott et al., these experiments examined whether occlusion and amodal…

  20. [Experimental model of venous hemorrhagic infarction by cerebral sinus occlusion].

    PubMed

    Fujita, K; Kojima, N; Matsumoto, S

    1984-08-01

    A new experimental model of the hemorrhagic infarction was devised to study the pathophysiology of the hemorrhagic infarction of the venous origin. To make a model of the hemorrhagic infarction by sinus occlusion, mixture of alpha-cyanoacrylate monomer and pantopaque was injected through a catheter introduced into the superior sagittal sinus in 15 dogs, using embolization technique. These dogs were divided into three groups according to the volume of the mixture injected into the sinus. In control groups (3 dogs), no mixture was injected. For partial sinus occlusion (5 dogs), 0.5-1.0 ml of mixture was injected into the sinus and 1.0-1.5 ml of mixture, for complete sinus occlusion (7 dogs). Changes of intracranial pressure (ICP), superior sagittal sinus pressure (SSSP), tissue pressure (TP) rCBF and histological changes were evaluated before and after sinus occlusion. The following results were obtained. (1) In control groups, ICP, SSSP and TP were 9 +/- 2.2 mmHg, 4 +/- 2.5 mmHg and 4-5 mmHg respectively, but in partial and complete sinus occlusion, SSSP and TP were higher than ICP. ICP, SSSP & TP were 32 +/- 5.4 mmHg, 35 +/- 6.5 mmHg and 37-42 mg, in partial sinus occlusion and 62 +/- 5.9 mmHg, 65 +/- 6.0 mmHg, 65-72 mmHg in complete sinus occlusion. (2) R-CBF in partial sinus occlusion showed no change even after sinus occlusion, but in complete sinus occlusion, decreased to 20% of that of the control group due to marked venous congestion.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:6504262

  1. Humanized Chronic Graft-versus-Host Disease in NOD-SCID il2r?-/- (NSG) Mice with G-CSF-Mobilized Peripheral Blood Mononuclear Cells following Cyclophosphamide and Total Body Irradiation

    PubMed Central

    Fujii, Hisaki; Luo, Zhi-Juan; Kim, Hye Jin; Newbigging, Susan; Gassas, Adam; Keating, Armand; Egeler, R. Maarten

    2015-01-01

    Chronic graft-versus-host disease (cGvHD) is the major source of late phase morbidity and mortality after allogeneic hematopoietic stem cell transplantation. Humanized acute GvHD (aGvHD) in vivo models using NOD-SCID il2r?-/- (NSG) mice are well described and are important tools for investigating pathogenicity of human cells in vivo. However, there have been only few reported humanized cGvHD mouse models. We evaluated if prolonged inflammation driven by low dose G-CSF-mobilized human PBMCs (G-hPBMCs) would lead to cGvHD following cyclophosphamide (CTX) administration and total body irradiation (TBI) in NSG mice. Engraftment was assessed in peripheral blood (PB) and in specific target organs by either flow cytometry or immunohistochemistry (IHC). Tissue samples were harvested 56 days post transplantation and were evaluated by a pathologist. Some mice were kept for up to 84 days to evaluate the degree of fibrosis. Mice that received CTX at 20mg/kg did not show aGvHD with stable expansion of human CD45+ CD3+ T-cells in PB (mean; 5.8 to 23.2%). The pathology and fibrosis scores in the lung and the liver were significantly increased with aggregation of T-cells and hCD68+ macrophages. There was a correlation between liver pathology score and the percentage of hCD68+ cells, suggesting the role of macrophage in fibrogenesis in NSG mice. In order to study long-term survival, 6/9 mice who survived more than 56 days showed increased fibrosis in the lung and liver at the endpoint, which suggests the infiltrating hCD68+ macrophages may be pathogenic. It was shown that the combination of CTX and TBI with a low number of G-hPBMCs (1x106) leads to chronic lung and liver inflammation driven by a high infiltration of human macrophage and mature human T cells from the graft, resulting in fibrosis of lung and liver in NSG mice. In conclusion this model may serve as an important pre-clinical model to further current understanding of the roles of human macrophages in cGvHD. PMID:26176698

  2. Occlusal traits in developmental dyslexia: a preliminary study

    PubMed Central

    Perillo, Letizia; Esposito, Maria; Contiello, Mariarosaria; Lucchese, Alessandra; Santini, Annamaria Chiara; Carotenuto, Marco

    2013-01-01

    Aim The objective of the study reported here was to assess the orthodontic features in children affected by developmental dyslexia (DD). Patients and methods A total of 28 children affected by DD (22 boys, six girls; mean age: 9.78 ± 1.69 years) were compared with 51 healthy children (38 boys, 13 girls; mean age 9.41 ± 1.48; range 7–10 years). Reading and writing skills were evaluated along with orthodontic features. Results The DD and control groups were not significantly different in terms of total intelligence quotient (P = 0.441) and writing skills (P = 0.805 and P = 0.240, respectively), whereas significant differences were observed between the DD group and control group in both word reading (2.018 ± 1.714 vs 0.917 ± 0.563; P = 0.000) and non-word reading (2.537 ± 1.543 vs 0.862 ± 0.244; P = 0.000). Moreover, for many orthodontic features, there was no significant difference between the two groups; only in prevalence of diastemas (57.14%, P = 0.006), midline diastemas (46.42%, P = 0.007), overbite > 4 mm (71.42%, P = 0.006) and overjet > 4 mm (53.57%, P = 0.001), was there a statistically significant difference. According to univariate logistic regression analysis, the presence of diastemas (odds ratio [OR] 4.33; 95% confidence interval [CI] 1.61–11.65), midline diastemas (OR 4.68; 95% CI 1.61–13.43), an overbite >4 mm (OR 1.75; 95% CI 0.64–4.71), or an overjet >4 mm (OR 2.76; 95% CI 1.06–7.20) seems to play a role in the relationship between occlusal abnormalities and DD in children. Conclusion Children with DD tend to present with altered dental features, particularly in the area of the incisors, suggesting that a persistently different tongue kinematic profile may thus affect both the developmental variability of the tongue and lip and the occlusion. PMID:24009421

  3. Chronic bronchitis in textile workers

    Microsoft Academic Search

    R. M. Niven; A. M. Fletcher; C. A. Pickering; D. Fishwick; C. J. Warburton; J. C. Simpson; H. Francis; L. A. Oldham

    1997-01-01

    BACKGROUND: Exposure to cotton is known to produce a specific occupational disease known as byssinosis. A large population of textile workers was investigated to determine whether such exposure was also associated with chronic bronchitis once other possible aetiological factors had been accounted for. METHODS: A total of 2991 workers were investigated for the presence of symptoms compatible with chronic bronchitis.

  4. The Outback Catheter: A New Device for True Lumen Re-entry After Dissection During Recanalization of Arterial Occlusions

    SciTech Connect

    Hausegger, Klaus A., E-mail: klaus.hausegger@lkh-klu.at; Georgieva, Borjana; Portugaller, Horst; Tauss, Josef [University Hospital Graz, Auenbruggerplatz 9, 8036 Graz, Department of Radiology (Austria); Stark, Gerhard [University Hospital Graz, Graz, Department of Internal Medicine, Angiology (Austria)

    2004-01-15

    To report the initial experience with a new catheter system (The Outback catheter) designed to allow fluoroscopically controlled re-entry of the true arterial lumen after subintimal guidewire passage during recanalization procedures of arterial occlusions. The catheter was used in 10 patients with intermittent claudication caused by chronic segmental occlusions of the superficial femoral or popliteal arteries. In all patients, conventional guidewire recanalization had failed. In 8 patients, successful true lumen re-entry was achieved with the Outback catheter. Percutaneous transluminal angioplasty was successfully performed in these patients without complications. Two technical failures occurred in heavily calcified arteries. The Outback catheter was safe and effective when used in complicated recanalization procedures in the superficial femoral and popliteal artery and the tibial trunk.

  5. Occlusion as a measure for visual workload: an overview of TNO occlusion research in car driving.

    PubMed

    van der Horst, Richard

    2004-05-01

    A process-oriented approach by systematically studying driver performance, distraction, and workload is the way to go for assessing safety effects of new telematics applications in vehicles. These systems may strive for drivers' attention and possibly lead to distraction from the primary task. Visual occlusion techniques appear to be an effective means of studying drivers' visual information processing performance. Studies to illustrate this include identifying the minimum visual information drivers need for driving (asking for visual information) and the evaluation of driver support systems such as heading control and adaptive cruise control with respect to visual workload. In other applications the occlusion technique is used to exclude 'visual array' information from the optic flow field. The temporary exclusion of part of the visual field of view was applied in evaluating the effects of different types of driver's side rearview mirrors. PMID:15145281

  6. Logic-controlled occlusive cuff system

    NASA Technical Reports Server (NTRS)

    Baker, J. T.; Hoffler, G. W. (inventors); Hursta, W. N.

    1981-01-01

    An occlusive cuff system comprises a pressure cuff and a source of regulated compressed gas feeding the cuff through an electrically operated fill valve. An electrically operated vent valve vents the cuff to the ambient pressure. The fill valve is normally closed and the vent valve is normally open. In response to an external start signal, a logic network opens the fill valve and closes the vent valve, thereby starting the pressurization cycle and a timer. A pressure transducer continuously monitors the pressure in the cuff. When the transducer's output equals a selected reference voltage, a comparator causes the logic network to close the fill valve. The timer, after a selected time delay, opens the vent valve to the ambient pressure, thereby ending the pressurization cycle.

  7. Coil occlusion of a subclavian mycotic aneurysm.

    PubMed

    Kische, Stephan; Ince, Hüseyin; Peuster, Matthias

    2010-06-01

    We report the first successful application of nonferromagnetic embolization coils for endovascular exclusion of a mycotic right subclavian artery aneurysm. A 58-year-old woman presented with acute cervical pain and a pulsatile mass in the right supraclavicular fossa under antibiotic medication for subacute infectious endocarditis. Diagnostic work-up including duplex sonography, digital subtraction angiography, and magnetic resonance imaging demonstrated a saccular aneurysm of the extrathoracic right subclavian artery. As an alternative to open surgery or stent-graft repair, this pathology was electively treated by transcatheter coil embolization. No neurological deficit or ischemic symptoms were noted during 9 months clinical follow-up. Multislice computed tomography scan revealed complete occlusion of the mycotic aneurysm 6 months after the interventional procedure. Transcatheter closure with Inconel embolization coils is a cost-effective and safe therapeutic option in patients with mycotic aneurysm originating from the subclavian artery. PMID:20146324

  8. Occlusal plane analysis using the Broadrick flag.

    PubMed

    Small, Bruce W

    2005-01-01

    The determination of the occlusal plane can have a profound effect on the short- and long-term success of a restorative case. The fewer posterior interferences that result from the reconstruction means fewer problems for patients with their teeth, muscles, and temporomandibular joints. Proper utilization of the Broadrick flag on a semi-adjustable articulator will allow the dentist or laboratory technician to easily determine the ideal plane for each case. As mentioned earlier, the use of Monson's theory is only a starting point for the analysis. Patients come in different shapes and sizes and sometimes have mandibular incisors that are not positioned ideally. With a little experience and training, dentists can make the Broadrick flag an integral part of their practice. The Broadrick flag now has been adapted to several articulator systems, including Hanau (all models), Denar, Jensen (Artex--under development), and Kavo (Protar). PMID:16158790

  9. Prosthetic occlusive device for an internal passageway

    NASA Technical Reports Server (NTRS)

    Tenney, J. B., Jr. (inventor)

    1983-01-01

    An occlusive device is disclosed for surgical implant to occlude the lumen of an internal organ. The device includes a cuff having a backing collar and two isolated cuff chambers. The fluid pressure of one chamber is regulated by a pump/valve reservoir unit. The other chamber is unregulated in pressure but its fluid volume is adjusted by removing or adding fluid to a septum/reservoir by means of a hypodermic needle. Pressure changes are transmitted between the two cuff chambers via faying surfaces which are sufficiently large in contact area and thin as to transmit pressure generally without attenuation. By adjusting the fluid volume of the septum, the operating pressure of the device may be adjusted to accommodate tubular organs of different diameter sizes as well as to compensate for changes in the organ following implant without reoperation.

  10. [Segmental arteriosclerotic occlusion of the infrarenal aorta].

    PubMed

    Bätz, W; Grönniger, J; Klose, K J

    1986-02-01

    Atherosclerosis involving the terminal aorta usually is a diffuse process that commonly includes the iliac and femoral arteries. Less frequently, the lesions are limited to the infrarenal aortic segment with normal distal vessels. Patients with isolated occlusion or stenosis of the infrarenal aorta tend to be younger, more often female and have slower progression of atherosclerotic lesions. There is a causative relationship of this well-localized form of atherosclerosis to the use of oral contraceptives and heavy smoking. In 90% of the cases, surgery of these lesions is limited to endarterectomy. End results are satisfactory in a majority of the patients. Percutaneous transluminal angioplasty produces satisfactory early results for concentric stenosis, although long-term results have not yet been established. PMID:3516599

  11. Central retinal vein occlusion and pseudoexfoliation syndrome

    PubMed Central

    Karagiannis, Dimitrios; Kontadakis, Georgios A; Klados, Nektarios E; Tsoumpris, Ioannis; Kandarakis, Artemios S; Parikakis, Efstratios A; Georgalas, Ilias; Tsilimbaris, Miltiadis K

    2015-01-01

    Purpose The purpose of this study was to investigate the existence of pseudoexfoliation syndrome (PXF) as a risk factor for the development of central retinal vein occlusion (CRVO). Methods This was a retrospective, comparative study of the prevalence of pseudoexfoliation in three groups of patients: 48 patients with CRVO, 164 patients with branch retinal vein occlusion (BRVO), and 70 control patients (70 eyes). All patients were phakic and had no previous diagnosis of glaucoma. Patients were matched in terms of age and systemic hypertension. All patients had normal intraocular pressure (IOP) at presentation (defined as less than or equal to 21 mmHg). Results In the CRVO group, 14 out of 48 patients were diagnosed as having PXF (29.17%). In the BRVO group, 14 out of 164 patients had PXF (8.5%), and in the control group, six out of 70 patients had PXF (8.6%). Differences of percentage between groups were statistically significant (P<0.001, ?2 test). When comparing patient subgroup with ischemic CRVO with subgroup with non-ischemic CRVO, we found that in the ischemic CRVO group, 13 out of 27 patients were diagnosed as having PXF (48.15%), and in the non-ischemic CRVO group, one out of 21 patients was diagnosed as having PXF (4.7%; P<0.001, ?2 test). The relative odds of having CRVO in patients with PXF versus patients without PXF were 4.406 (confidence interval [CI], 2.03–9.54). Conclusion PXF and CRVO, especially ischemic, are strongly associated in our study. Our results indicate that PXF might be an independent factor for CRVO, as it is related with CRVO independently from glaucoma.

  12. Coherent spatial and temporal occlusion generation

    NASA Astrophysics Data System (ADS)

    Klein Gunnewiek, R.; Berretty, R.-P. M.; Barenbrug, B.; Magalhães, J. P.

    2009-02-01

    A vastly growing number of productions from the entertainment industry are aiming at 3D movie theatres. These productions use a two-view format, primarily intended for eye-wear assisted viewing in a well defined environment. To get this 3D content into the home environment, where a large variety of 3D viewing conditions exists (e.g different display sizes, display types, viewing distance), we need a flexible 3D format that can adjust the depth effect. Such a format is the image plus depth format in which a video frame is enriched with depth information of all pixels in the video. This format can be extended with an additional layer for occluded video and associated depth, that contains what is behind objects in the video. To produce 3D content in this extended format, one has to deduce what is behind objects. There are various axes along which this occluded data can be obtained. This paper presents a method to automatically detect and fill the occluded areas exploiting the temporal axis. To get visually pleasing results, it is of utmost importance to make the inpainting globally consistent. To do so, we start by analyzing data along the temporal axis and compute a confidence for each pixel. Then pixels from the future and the past that are not visible in the current frame are weighted and accumulated based on computed confidences. These results are then fed to a generic multi-source framework that computes the occlusion layer based on the available confidences and occlusion data.

  13. Caries process on occlusal surfaces: evolving evidence and understanding.

    PubMed

    Carvalho, J C

    2014-01-01

    Management of the caries process on occlusal surfaces of permanent molars has proven a major challenge. The onset of caries on these surfaces takes place soon after their eruption, and the permanent first molars, followed by the second molars, remain the sites in the dentition which show the highest caries prevalence. This paper is structured in the form of questions and answers in which traditional concepts of caries susceptibility of occlusal surfaces are appraised and confronted with the current evidence. Then, research studies examining the role of biological determinants on the development and arrest of occlusal caries in young permanent teeth are discussed. Finally, the contribution of these studies in terms of developing the available scientific evidence and our understanding of the caries process on occlusal surfaces is analyzed. The current evidence does not support the concept that the early onset and high prevalence of occlusal caries in young permanent teeth are due to a particularly low inherent resistance of the occlusal surface or due to the presence of inaccessible fissure-like structures on these surfaces. Evidence is provided to show that the most influential biological determinants of the development and arrest of occlusal caries are thick plaque accumulation on the groove-fossa system and the stage of tooth eruption limiting mechanical oral function. Consequently, active occlusal lesions are significantly more prevalent in erupting than in fully erupted teeth. The major contribution of this review is to provide updated knowledge about the biological principles determining the development and arrest of caries on occlusal surfaces of erupting teeth. PMID:24577073

  14. Evaluation of the correlation between dental occlusion and posture using a force platform

    PubMed Central

    Baldini, Alberto; Nota, Alessandro; Tripodi, Domenico; Longoni, Salvatore; Cozza, Paola

    2013-01-01

    OBJECTIVES: Force platforms are widely used to evaluate the relationship between posture and dental occlusion. This study evaluated whether force platforms are able to detect eventual postural modifications resulting from dental occlusion. METHOD: A total of 44 healthy volunteers who were given no information on the aim of the study underwent six postural stabilometric exams under different mandibular and visual conditions. Four parameters were considered: sway area, sway velocity, X axis displacement of the center of the foot pressure and Y axis displacement of the center of the foot pressure. RESULTS: An analysis of variance (ANOVA) revealed the relative influence of each factor; specifically, the ocular afference significantly influenced the sway area and sway velocity parameters, and the mandibular position had only a weak influence on the sway area parameter. CONCLUSIONS: Vision was shown to influence body posture, and a weak correlation was observed between mandibular position and body posture in healthy subjects. However, the force platform is most likely not able to clearly detect this relationship. Gnathologists must use caution when using force platform analysis to modify a therapeutic plan. The sway area seems to be the most sensitive parameter for evaluating the effect of occlusion on body posture. PMID:23420156

  15. Relationship between angiotensin I-converting enzyme insertion/deletion gene polymorphism and retinal vein occlusion

    PubMed Central

    2014-01-01

    To evaluate the association between angiotensin I-converting enzyme insertion/deletion (ACE I/D) gene polymorphism and retinal vein occlusion (RVO). A total of 80 patients with retinal vein occlusion who was admitted to the Eye Department of Kartal Training and Research Hospital between 2008 and 2011, and 80 subjects were enrolled in this retrospective case–control study. Patients who experienced RVO within one week to six months of study enrolment were included, and those with coronary artery diseases, prior myocardial infarction history and coagulation disturbances were excluded from the study. The diagnosis was made by ophthalmoscopic fundus examination and fluorescein angiography. The ACE gene I/D polymorphism was determined by polymerase chain reaction, and the ACE gene was classified into three types: I/I, I/D and D/D. In multivariate logistic regression analysis, ACE D/D genotype (p?=?0.035), diabetes-mellitus (p?=?0.019) and hypertension (p?=?0.001) were found to be independent predictive factors for RVO. The results of the present study reveal that ACE D/D polymorphism is an independent predictive factor for RVO. However, one cannot definitely conclude that ACE gene polymorphism is a risk factor for retinal vein occlusion. PMID:25161389

  16. Central Retinal and Posterior Ciliary Artery Occlusion After Intralesional Injection of Sclerosant to Glabellar Subcutaneous Hemangioma

    SciTech Connect

    Matsuo, Toshihiko, E-mail: matsuot@cc.okayama-u.ac.j [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Ophthalmology (Japan); Fujiwara, Hiroyasu; Gobara, Hideo; Mimura, Hidefumi; Kanazawa, Susumu [Okayama University Graduate School of Medicine, Dentistry, and Pharmaceutical Sciences, Department of Radiology (Japan)

    2009-03-15

    The aim of this study is to describe vision loss caused by central retinal artery and posterior ciliary artery occlusion as a consequence of sclerotherapy with a polidocanol injection to a glabellar hemangioma. An 18-year-old man underwent direct injection with a 23-gauge needle of 1 mL of a polidocanol-carbon dioxide emulsion into the glabellar subcutaneous hemangioma under ultrasound visualization of the needle tip by radiologists. He developed lid swelling the next day, and 3 days later at referral, the visual acuity in the left eye was no light perception. Funduscopy revealed central retinal artery occlusion and fluorescein angiography disclosed no perfusion at all in the left fundus, indicating concurrent posterior ciliary artery occlusion. The patient also showed mydriasis, blepharoptosis, and total external ophthalmoplegia on the left side. Magnetic resonance imaging demonstrated the swollen medial rectus muscle. In a month, blepharoptosis and ophthalmoplegia resolved but the visual acuity remained no light perception. Sclerosing therapy for facial hemangioma may develop a severe complication such as permanent visual loss.

  17. Chronic inflammatory polyneuropathy

    MedlinePLUS

    Polyneuropathy - chronic inflammatory; CIDP; Chronic inflammatory demyelinating polyneuropathy ... usually affects both sides of the body equally. Chronic inflammatory demyelinating polyneuropathy (CIDP) is the most common chronic neuropathy caused ...

  18. Occlusion-amblyopia following high dose oral levodopa combined with part time patching.

    PubMed

    Kothari, Mihir

    2014-12-01

    Part time occlusion therapy is not reported to cause occlusion (reverse) amblyopia. However, when combined with high dose oral levodopa, an increase in the plasticity of the visual cortex can lead to occlusion amblyopia. In this case report, we describe a six year old child who developed occlusion amblyopia following part time patching combined with oral levodopa. PMID:23571255

  19. Occlusion-amblyopia following high dose oral levodopa combined with part time patching

    PubMed Central

    Kothari, Mihir

    2014-01-01

    Part time occlusion therapy is not reported to cause occlusion (reverse) amblyopia. However, when combined with high dose oral levodopa, an increase in the plasticity of the visual cortex can lead to occlusion amblyopia. In this case report, we describe a six year old child who developed occlusion amblyopia following part time patching combined with oral levodopa. PMID:23571255

  20. Aortic Bifurcation Reconstruction: Use of the Memotherm Self-Expanding Nitinol Stent for Stenoses and Occlusions

    SciTech Connect

    Houston, J. Graeme [Directorate of Clinical Radiology, Dundee Teaching Hospitals NHS Trust, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland (United Kingdom); McCollum, Peter T.; Stonebridge, Peter A.; Raza, Zahid [Department of Vascular Surgery, Dundee Teaching Hospitals NHS Trust, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland (United Kingdom); Shaw, J. William [Directorate of Clinical Radiology, Dundee Teaching Hospitals NHS Trust, Ninewells Hospital and Medical School, Dundee DD1 9SY, Scotland (United Kingdom)

    1999-03-15

    Purpose: To assess the technical success, initial clinical outcome, and intermediate follow-up of the Memotherm nitinol self-expanding stent in aortic bifurcation reconstruction. Methods: Thirty-three patients (13 male, 20 female), mean age 64 years, were treated, who had symptoms classified by the Surgical Vascular Society/International Society of Cardiovascular Surgery (SVS/ICVS) classification as grade 2 in 11 (33%), grade 3 in 19 (58%) and grade 4 in 3 (9%) patients. Lesions were classified according to severity and type. Indications for placement of a Memotherm nitinol self-expanding stent were failed angioplasty in 14 (42%), chronic occlusions in 12 (37%), and complex stenoses in seven (21%) patients. Results: Sixty-seven stents were technically successfully placed in 66 aorto-iliac segments in 33 patients, with one major complication. Initial clinical outcome was improvement in 25 (81%), no change in four (13%), and a worsening in two (6%) patients by Rutherford criteria. Mean early ankle/brachial pressure index (ABI) gain was 0.27 for occlusions and 0.05 for stenoses. Clinical follow-up was obtained in all patients, with retrospective angiographic follow-up in 28 (85%) at a mean of 16 months (range 12-26 months). The decrease in ABI and the decrease in angiographic luminal diameter at follow-up was determined as the 'late loss.' The mean ABI late losses were -0.06, 0.00, and 0.09, and the mean angiographic late losses were 6.7%, 10% and 14% for occlusions, stenoses, and normal segments respectively. Primary clinical patency was 96%, primary angiographic patency was 89%, and secondary angiographic patency was 93%. Conclusion: The high technical success of stent placement, the low complication rates for aortic bifurcation reconstruction using the Memotherm self-expanding stent, and high clinical and angiographic patency maintained at intermediate follow-up support their use in aortic bifurcation reconstruction.

  1. Use of PTFE Stent Grafts for Hemodialysis-related Central Venous Occlusions: Intermediate-Term Results

    SciTech Connect

    Kundu, Sanjoy, E-mail: sanjoy_kundu40@hotmail.com; Modabber, Milad [Scarborough General Hospital-General Division, Department of Medical Imaging (Canada); You, John M. [Scarborough General Hospital-General Division, Department of Vascular Surgery (Canada); Tam, Paul; Nagai, Gordon; Ting, Robert [Scarborough General Hospital-General Division, Department of Nephrology (Canada)

    2011-10-15

    Purpose: To assess the safety and effectiveness of a polytetrafluoroethylene (PTFE) encapsulated nitinol stents (Bard Peripheral Vascular, Tempe, AZ) for treatment of hemodialysis-related central venous occlusions. Materials and Methods: Study design was a single-center nonrandomized retrospective cohort of patients from May 2004 to August 2009 for a total of 64 months. There were 14 patients (mean age 60 years, range 50-83 years; 13 male, 1 female). All patients had autogenous fistulas. All 14 patients had central venous occlusions and presented with clinical symptoms of the following: extremity swelling (14%, 2 of 14), extremity and face swelling (72%, 10 of 14), and face swelling/edema (14%, 2 of 14). There was evidence of access dysfunction with decreased access flow in 36% (5 of 14) patients. There were prior interventions or previous line placement at the site of the central venous lesion in all 14 patients. Results were assessed by recurrence of clinical symptoms and function of the access circuit (National Kidney Foundation recommended criteria). Results: Sixteen consecutive straight stent grafts were implanted in 14 patients. Average treated lesion length was 5.0 cm (range, 0.9-7 cm). All 14 patients had complete central venous occlusion (100% stenosis). The central venous occlusions were located as follows: right subclavian and brachiocephalic vein (21%, 3 of 14), right brachiocephalic vein (36%, 5 of 14), left brachiocephalic vein (36%, 5 of 14), and bilateral brachiocephalic vein (7%, 1 of 14). A total of 16 PTFE stent grafts were placed. Ten- or 12-mm-diameter PTFE stent grafts were placed. The average stent length was 6.1 cm (range, 4-8 cm). Technical (deployment), anatomic (<30% residual stenosis), clinical (resolution of symptoms), and hemodynamic (resolution of access dysfunction) success were 100%. At 3, 6, and 9 months, primary patency of the treated area and access circuit were 100% (14 of 14). Conclusions: This PTFE encapsulated stent graft demonstrates encouraging intermediate-term patency results for central vein occlusions. Further prospective studies with long-term assessment and larger patient populations will be required.

  2. Chronic Depression

    Microsoft Academic Search

    Lawrence P. Riso; Michael E. Thase

    While once of limited interest to the field, chronic depression is now recognized as a major public health problem (Howland, 1993). Not only is chronic depression common, representing 19% of all depressed patients (Keller & Hanks, 1995) and 6% in the community (Kessler et al., 1994), but it is also associated with considerable psychosocial impairment (Howland, 1993), and is extremely

  3. [Chronic leukemia].

    PubMed

    Shibata, A; Narita, M

    1989-05-01

    As compared with advances in the treatment of acute leukemia, we have made little progress in chronic leukemia. Recently we have attempted some new treatments for chronic phase of CML, and confirmed those effectiveness. But for blastic crisis, we still grope in the dark. In this paper, we review the chemotherapy of CML and CLL including new treatments except bone marrow transplantation. PMID:2658837

  4. Percutaneous Retrograde Recanalization of the Celiac Artery by Way of the Superior Mesenteric Artery for Chronic Mesenteric Ischemia

    SciTech Connect

    Joseph, George, E-mail: joseph59@gmail.com; Chacko, Sujith Thomas [Christian Medical College, Department of Cardiology (India)] [Christian Medical College, Department of Cardiology (India)

    2013-02-15

    A 52-year-old man presented with recurrent postprandial abdominal pain, sitophobia, and progressive weight loss. Chronic mesenteric ischemia (CMI) due to subtotal occlusion of the superior mesenteric artery (SMA) and flush occlusion of the celiac artery (CA) was diagnosed. Retrograde recanalization of the CA by way of a collateral channel from the SMA was performed using contemporary recanalization equipment. The CA and SMA were then stented, resulting in sustained resolution of CMI-related symptoms.

  5. Punctal occlusion for dry eye syndrome

    PubMed Central

    Ervin, Ann-Margret; Wojciechowski, Robert; Schein, Oliver

    2012-01-01

    Background Dry eye syndrome is a disorder of the tear film and is associated with symptoms of ocular discomfort. Punctal occlusion is a mechanical treatment in which the tear drainage system is blocked in order to aid in the preservation of natural tears on the ocular surface. Objectives The objective of this review was to assess the safety and efficacy of punctal plugs for the management of dry eye. Search methods We searched the Cochrane Central Register of Controlled Trials (CENTRAL) (which contains the Cochrane Eyes and Vision Group Trials Register) (The Cochrane Library 2010, Issue 6), MEDLINE (January 1950 to June 2010), EMBASE (January 1980 to June 2010), Latin American and Caribbean Literature on Health Sciences (LILACS) (January 1982 to June 2010), the metaRegister of Controlled Trials (mRCT) (www.controlled-trials.com) and ClinicalTrials.gov (http://clinicaltrials.gov). We also searched the Science Citation Index-Expanded database and reference lists of included studies. There were no language or date restrictions in the search for trials. The electronic databases were last searched on 21 June 2010. Selection criteria We included randomized and quasi-randomized controlled trials of collagen or silicone punctal plugs in symptomatic participants diagnosed with aqueous tear deficiency or dry eye syndrome. Data collection and analysis Two review authors independently assessed trial quality and extracted data. We contacted study investigators for additional information. Main results Seven randomized controlled trials including 305 participants (601 eyes) met the inclusion criteria and are summarized in this review. We did not perform meta-analysis due to appreciable variability in interventions and follow-up intervals. Although punctal plugs provided symptomatic improvement and clinical outcomes also improved from baseline measures, few studies demonstrated a benefit of punctal plugs over the comparison intervention. Reported adverse effects included epiphora (overflow of tears), foreign body sensation, eye irritation, and spontaneous plug loss. Authors’ conclusions This systematic review shows a relative scarcity of controlled clinical trials assessing the efficacy of punctal occlusion therapy in dry eye. Although the evidence is very limited, the data suggest that silicone plugs can provide symptomatic relief in severe dry eye. Moreover, temporary collagen plugs appear similarly effective to silicone plugs on a short-term basis. PMID:20824852

  6. Occlusion-free next view planning

    NASA Astrophysics Data System (ADS)

    Zeng, Jianchao; Xu, Guang-you

    1993-08-01

    In this paper, a new approach is proposed to plan occlusion-free next view for a light stripe range finder. To expand its viewing scope, the range finder is mounted on the gripper of a manipulator so that it can take range images at any point in the space from any direction. In order to avoid self occlusion from occurring, we make the light plane of each striping orthogonal to the tangent plane of some representative point (RP) on the object, and maintain constant the distance between the view point and the RP. Instead of blind scanning to obtain dense range images of the object, we utilize already acquired data as knowledge to plan the next scanning view purposively. First, the range finder is guided right above the object by processing an intensity image taken from above the worktable, and an optimal initial scanning direction is determined through test stripings. Secondly, four initial stripings along the scanning direction with a default displacement are carried out, and their images are segmented at abrupt and sharp turning points. The longest corresponding segments are first fitted with a B-splines surface, and the middle point of the boundary along the scanning direction is viewed as RP for the initial patch. The next view point is determined by approximating the surface with a cylindrical surface within a small neighboring area around the RP, calculating the curvature and torsion of the spiral curve on the cylindrical surface passing through the RP. Thirdly, the initial patch is extended to a new one by merging the stripe from the determined view point. This procedure is repeated until touch of the object with the worktable is reached. And finally, we get complete description by connecting all the patches starting from each initial segment. As can be seen from the above, the proposed approach acts very close to the perception process of a human. We utilize a simulation system to show the effectiveness of our approach and its advantages over the existing ones.

  7. Bilateral atherosclerotic internal carotid artery occlusion and recurrent ischaemic stroke.

    PubMed

    Amin, Osama S M

    2015-01-01

    Bilateral internal carotid artery occlusion (BICAO) is a rare disease that carries a gloomy prognosis. We report a case of a 52-year-old man who developed ischaemic infarction at the region of the right middle cerebral artery; he was found to have atherosclerotic occlusion of both internal carotid arteries on Doppler-duplex examination. He received medical treatment only. After 1?year, he developed a new infarction at the region of the left middle cerebral artery. Conventional angiography revealed bilateral occlusion of internal carotid arteries at their origin, approximately 50% stenosis of the common carotid bulbs and mild stenosis of the origin of external carotid arteries. The patient did not undergo any form of surgical revascularisation procedures and died of severe aspiration pneumonia approximately 2?months after the second stroke. BICAO portends a poor outcome and carries a risk of recurrent ischaemic events. The best management strategy for this vascular occlusion remains unclear. PMID:26055760

  8. Computational confocal tomography for simultaneous reconstruction of objects, occlusions,

    E-print Network

    Fainman, Yeshaiahu

    Computational confocal tomography for simultaneous reconstruction of objects, occlusions computationally intense and novel reconstruction methods that we called "compu- tational confocal tomography." The key to computed tomography is the collection of projections of the data over a range of angles

  9. Diagnosis and management of occlusal wear: a case report.

    PubMed

    Thirumurthy, V R; Bindhoo, Y A; Jacob, Sunil Joseph; Kurien, Anjana; Limson, K S; Vidhiyasagar, P

    2013-09-01

    The rationale for doing full mouth rehabilitation are, when occlusal forces become traumatic hampering the health of periodontal tissues, extensive occlusal diseases, trauma, temporomandibular joint disease and congenital disorders with malformed dentition. Literature exposes that full mouth fixed rehabilitation is one of the taxing procedures in the field of Prosthodontics. A critical aspect for successful occlusal rehabilitation is to determine the aetiology, correct sequence of treatment and most importantly the occlusal vertical dimension and centric relation in which to plan the treatment. A systematic approach in managing these patients can lead to a predictable and favourable prognosis. This article presents the stages of prosthodontic rehabilitation, from diagnosis to final treatment and follow-up, of a bruxer patient with severely worn dentition. PMID:24431762

  10. Glottalized and Murmured Occlusives in Indo-European

    ERIC Educational Resources Information Center

    Hopper, Paul J.

    1973-01-01

    In phonetical terminology, a consonant produced by completely closing the nasal and oral air passages (implosion), resulting in a retention of air, and then suddenly opening the closure (explosion), is known as occlusive. (DD)

  11. Detection and handling of occlusion in an object detection system

    NASA Astrophysics Data System (ADS)

    Op het Veld, R. M. G.; Wijnhoven, R. G. J.; Bondarev, Y.; de With, Peter H. N.

    2015-03-01

    Object detection is an important technique for video surveillance applications. Although different detection algorithms were proposed, they all have problems in detecting occluded objects. In this paper, we propose a novel system for occlusion handling and integrate this in a sliding-window detection framework using HOG features and linear classification. The occlusion handling is obtained by applying multiple classifiers, each covering a different level of occlusion and focusing on the non-occluded object parts. Experiments show that our approach based on 17 classifiers, obtains an increase of 8% in detection performance. To limit computational complexity, we propose a cascaded implementation that only increases the computational cost by 3.4%. Although the paper presents results for pedestrian detection, our approach is not limited to this object class. Finally, our system does not need an additional dataset for training, covering all possible types of occlusions.

  12. 21 CFR 880.5950 - Umbilical occlusion device.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ...Identification. An umbilical occlusion device is a clip, tie, tape, or other article used to close the blood vessels in the umbilical cord of a newborn infant. (b) Classification. Class I (general controls). The device is exempt...

  13. 21 CFR 880.5950 - Umbilical occlusion device.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ...Identification. An umbilical occlusion device is a clip, tie, tape, or other article used to close the blood vessels in the umbilical cord of a newborn infant. (b) Classification. Class I (general controls). The device is exempt...

  14. 21 CFR 880.5950 - Umbilical occlusion device.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ...Identification. An umbilical occlusion device is a clip, tie, tape, or other article used to close the blood vessels in the umbilical cord of a newborn infant. (b) Classification. Class I (general controls). The device is exempt...

  15. Acute left main occlusion during transcatheter aortic valve implantation.

    PubMed

    Kleczy?ski, Pawe?; Witkowski, Adam; Tr?bacz, Jaros?aw; Sorysz, Danuta; Rzeszutko, Lukasz; Sobczy?ski, Robert; Dziewierz, Artur; Zmudka, Krzysztof; Sadowski, Jerzy; Dudek, Dariusz

    2013-01-01

    We present a case of a 92 year-old female with severe aortic stenosis who underwent TAVI. The procedure resulted with acute left main coronary artery occlusion requiring an immediate percutaneous coronary intervention. PMID:23797447

  16. Correlation between inclination of occlusal plane and masticatory movement

    Microsoft Academic Search

    T. Ogawa; K. Koyano; T. Suetsugu

    1998-01-01

    Objectives: The purpose of this study was to investigate the relationship between the inclination of the occlusal plane and masticatory movement.Methods: Masticatory movements of 41 young adults were measured using the three-dimensional Mandibular Movement Analyzing System. The inclination of the occlusal plane was measured in the sagittal plane using a three-dimensional digitizer.Results: In the sagittal plane, the masticatory closing path

  17. Multi-cue pedestrian classification with partial occlusion handling

    Microsoft Academic Search

    Markus Enzweiler; Angela Eigenstetter; Bernt Schiele; Dariu M. Gavrila

    2010-01-01

    This paper presents a novel mixture-of-experts framework for pedestrian classification with partial occlusion handling. The framework involves a set of component-based expert classifiers trained on features derived from intensity, depth and motion. To handle partial occlusion, we compute expert weights that are related to the degree of visibility of the associated component. This degree of visibility is determined by examining

  18. Human body modeling with partial self occlusion from monocular camera

    Microsoft Academic Search

    Chih-Chang Yu; Hsu-Yung Cheng; Jenq-Neng Hwang; Kuo-Chin Fan

    2008-01-01

    Automated human body modeling from monocular video sequences is a challenging task because humans may possess very sophisticated postures with various types of motions. The self-occlusion problem often makes body parts invisible in a period of time. In this paper, we propose an automated contour-based 2D human modeling system which is able to deal with partial self-occlusion problem. The 2D

  19. Dental occlusion and body posture: No detectable correlation

    Microsoft Academic Search

    Giuseppe Perinetti

    2006-01-01

    The present study was designed to determine if a correlation could be found between dental occlusion and body posture through posturography. Twenty-six healthy subjects (mean age 26.8±5.3 years) were monitored under opposing visual (eyes open\\/closed) and dental occlusion (mandibular rest\\/intercuspidation positions) conditions. The spatial (absolute displacement of centre of pressure from the theoretical point; ACOPD) and dynamic (sway area, length

  20. Occlusive vascular disease associated with cerebral arteriovenous malformations

    SciTech Connect

    Mawad, M.E.; Hilal, S.K.; Michelsen, W.J.; Stein, B.; Ganti, S.R.

    1984-11-01

    Selective carotid angiography and computed tomography were used in a study of the association of occlusive vascular disease with cerebral arteriovenous malformations in 13 patients. The majority of the arterial occlusions were proximal to the vascular malformation. Some, however, extended distal to the major branch supplying the arteriovenous malformation (AVM). Selective angiography with subtraction techniques defines the distinct angioarchitecture of these AVMs and the associated stenoses and collateral telangiectases.

  1. On an analysis of static occlusion in stereo vision

    Microsoft Academic Search

    Chienchung Chang; Shankar Chatterjee; P. R. Kube

    1991-01-01

    The authors consider the problem of occlusion in computing stereo disparity from a pair of images. Usual approaches to stereo matching, e.g. area-based, feature-based, etc., can perform poorly in the neighborhood of occluding boundaries if no surface models are assumed. Qualitative improvements are possible based on conditions derived from the geometry of occlusion. A pair of correspondence processes, using information

  2. Pathophysiological aspects of sickle cell vaso-occlusion

    SciTech Connect

    Nagel, R.L.

    1987-01-01

    This book contains over 30 selections. Some of the titles are: An Animal Model for Sickle Cell Vaso-Occlusion: A Study Using NMR and Technetium Imaging; Sickle-Cell Vaso-Occlusion in an Animal Model: Intravital Microscopy and Radionuclide Imaging of Selective Sequestration of Dense Cells; Magnetic Resonance Imaging, Percentage of Dense Cells, and Serum Prostanoids as Tools for Objective Assessment of Pain Crisis: A Preliminary Report; and Painful Crisis and Dense Echinocytes: Effects of Hydration and Vasodilators.

  3. Bilateral retinal artery occlusion due to mitral valve prolapse.

    PubMed Central

    van Rhee, F.; Blecher, T. E.; DeLepeleire, K. A.; Galloway, N. R.

    1991-01-01

    We report a case of bilateral retinal artery occlusion due to mitral valve prolapse. Most patients with retinal ischaemia in whom it is found have not been previously known to have it. Since it is a common condition it would seem essential that it be included in the differential diagnosis of amaurosis fugax and retinal artery occlusion if future ischaemic events are to be prevented. All patients with retinal ischaemia should have a full cardiovascular examination supplemented by echocardiography. Images PMID:1854701

  4. Branch retinal vein occlusion treated by intravitreal triamcinolone acetonide

    Microsoft Academic Search

    J B Jonas; I Akkoyun; B Kamppeter; I Kreissig; R F Degenring

    2005-01-01

    PurposeTo evaluate the effect of intravitreal triamcinolone acetonide on visual acuity in branch retinal vein occlusion.MethodsThe prospective comparative nonrandomized clinical interventional study included 28 patients (28 eyes) with branch retinal vein occlusion. The study group consisting of 10 consecutive patients received an intravitreal injection of 20–25 mg of triamcinolone acetonide. The control group including 18 patients did not receive an

  5. An automated dental caries detection and scoring system for optical images of tooth occlusal surface.

    PubMed

    Ghaedi, Leila; Gottlieb, Riki; Sarrett, David C; Ismail, Amid; Belle, Ashwin; Najarian, Kayvan; Hargraves, Rosalyn Hobson

    2014-08-01

    Dental caries are one of the most prevalent chronic diseases. The management of dental caries demands detection of carious lesions at early stages. This study aims to design an automated system to detect and score caries lesions based on optical images of the occlusal tooth surface according to the International Caries Detection and Assessment System (ICDAS) guidelines. The system detects the tooth boundaries and irregular regions, and extracts 77 features from each image. These features include statistical measures of color space, grayscale image, as well as Wavelet Transform and Fourier Transform based features. Used in this study were 88 occlusal surface photographs of extracted teeth examined and scored by ICDAS experts. Seven ICDAS codes which show the different stages in caries development were collapsed into three classes: score 0, scores 1 and 2, and scores 3 to 6. The system shows accuracy of 86.3%, specificity of 91.7%, and sensitivity of 83.0% in ten-fold cross validation in classification of the tooth images. While the system needs further improvement and validation using larger datasets, it presents promising potential for clinical diagnostics with high accuracy and minimal cost. This is a notable advantage over existing systems requiring expensive imaging and external hardware. PMID:25570356

  6. Combination of Rotational Atherothrombectomy and Paclitaxel-Coated Angioplasty for Femoropopliteal Occlusion

    PubMed Central

    Scheer, F; Lüdtke, CW; Kamusella, P; Wiggermann, P; Vieweg, H; Schlöricke, E; Lichtenberg, M; Andresen, R; Wissgott, C

    2014-01-01

    OBJECTIVE The rotational atherothrombectomy with Straub Rotarex® is a safe and efficient treatment of acute/subactute vascular occlusions. The purpose of this study was to evaluate the benefit of paclitaxel-coated angioplasty after rotational atherothrombectomy over an observation period of six months. MATERIALS AND METHODS Overall, 29 patients were treated with the Rotarex catheter in combination with paclitaxel-coated angioplasty. All patients had acute/subacute and chronic occlusions of the superficial femoral artery (SFA) and/or popliteal arteries. The ankle-brachial index (ABI) was detected before the intervention, after the procedure, and after six months. Also clinical examination and ultrasound scans were done in the observation period. RESULTS There were no technical failures. The ABI shows a significant increase from 0.52 ± 0.17 to 0.91 ± 0.25 in the follow-up. By ultrasound examination, there were found two (6.9%) restenoses during the follow-up. There was one dissection during the intervention (3.5%). CONCLUSION The rotational atherothrombectomy in combination with paclitaxel-coated angioplasty might be an effective and safe method with a promising low rate of restenosis at six months. PMID:25983558

  7. Transient Occlusion of Uterine Arteries in Laparoscopic Uterine Surgery

    PubMed Central

    Kwon, Yong-Soon; Roh, Hyun Jin; Ahn, Jun Woo; Lee, Sang-Hun

    2015-01-01

    Background and Objectives: This study was conducted to determine the feasibility and effectiveness of transient occlusion of the uterine arteries (TOUA) during laparoscopic surgery for benign uterine tumors, with preservation of fertility. Methods: Patients with uterine myoma or adenomyoma underwent laparoscopic uterine surgery, with or without TOUA, performed by a single surgeon (Y.-S.K.). Surgical outcomes included operative time; occurrence of intraoperative injury of blood vessels, nerves, and pelvic organs; and intraoperative blood loss. Results: Of the 168 surgical patients included in this study, 144 were enrolled consecutively during the study period, and 24 had undergone adenomectomy before the study period. A total of 104 women (70 with myoma; 34 with adenomyoma) seeking uterine preservation underwent laparoscopic surgery with TOUA for benign uterine tumors. Sixty-four women (40 with myoma; 24 with adenomyoma) underwent surgery without TOUA. The mean total surgical time of the TOUA groups was 74.85 minutes for uterine myoma and 84.09 minutes for uterine adenomyoma. The mean estimated blood loss during laparoscopic myomectomy and adenomyomectomy was less in the TOUA groups than in the non-TOUA groups (109 vs. 203.4 mL in myomectomy, P < .05; 148.1 vs. 158.9 mL in adenomyomectomy; P < .05). Time to perform TOUA was 13.9 minutes in laparoscopic myomectomy and 7.33 minutes in laparoscopic adenomyomectomy. The hospital stay of the TOUA groups was 3.32 days for uterine myoma and 3.82 days for uterine adenomyoma. No intraoperative conversion to laparotomy was necessary, and no major complications occurred during any of the procedures. Conclusion: Laparoscopic uterine surgery with TOUA could be a safe and effective surgical method for women with symptomatic benign uterine tumors who wish to preserve fertility. PMID:25848179

  8. Occlusion regulates epidermal cytokine production and inhibits scar formation.

    PubMed

    Gallant-Behm, Corrie L; Mustoe, Thomas A

    2010-01-01

    Hypertrophic scars are a major clinical problem, yet there are few therapeutics available to prevent or treat scar formation. One of the oldest known and most effective treatments is occlusion with silicone gel. However, little is known about its mode of action. It is hypothesized that occlusion increases the hydration state of the epidermis, and that this affects the epidermal and dermal cell behavior. This study investigated this possibility. Using the rabbit hypertrophic scar model, we determined that occlusion increased the hydration state of the epidermis in a dose-dependent manner, and significantly reduced the scar hypertrophy. Quantitative reverse transcription-polymerase chain reaction and immunohistochemistry showed that occlusion altered keratinocyte behavior, including keratin expression. Furthermore, occlusion significantly decreased the epidermal expression of the profibrotic cytokine interleukin-1beta and increased the epidermal expression of the antifibrotic cytokine tumor necrosis factor alpha. These alterations in the epidermal gene expression resulted in concomitant changes in the expression of the transforming growth factor-beta family members by cells in the dermis, resulting in a decrease in profibrotic signaling within the dermis. In summary, the results of this study indicate that occlusive therapy was able to decrease dermal fibrosis by hydrating the epidermis and altering the pro- and antifibrotic signals produced following injury. PMID:20419876

  9. Prefrontal Hemodynamic Changes Associated with Subjective Sense of Occlusal Discomfort

    PubMed Central

    Kobayashi, Goh; Hayama, Rika; Ikuta, Ryuhei; Onozouka, Minoru; Wake, Hiroyuki; Shimada, Atsushi; Shibuya, Tomoaki; Tamaki, Katsushi

    2015-01-01

    We used functional near-infrared spectroscopy to measure prefrontal brain activity accompanying the physical sensation of oral discomfort that arose when healthy young-adult volunteers performed a grinding motion with mild occlusal elevation (96??m). We simultaneously evaluated various forms of occlusal discomfort using the visual analogue scale (VAS) and hemodynamic responses to identify the specific prefrontal activity that occurs with increased occlusal discomfort. The Oxy-Hb responses of selected channels in the bilateral frontopolar and dorsolateral prefrontal cortices increased in participants who reported increased severity of occlusal discomfort, while they decreased in those who reported no change or decreased occlusal discomfort during grinding. Moreover, the cumulative values of Oxy-Hb response in some of these channels were statistically significant predictive factors for the VAS scores. A generalized linear model analysis of Oxy-Hb signals in a group of participants who reported increased discomfort further indicated significant cerebral activation in the right frontopolar and dorsolateral prefrontal cortices that overlapped with the results of correlation analyses. Our results suggest that the increased hemodynamic responses in the prefrontal area reflect the top-down control of attention and/or self-regulation against the uncomfortable somatosensory input, which could be a possible marker to detect the subjective sense of occlusal discomfort.

  10. Suprarenal vena caval occlusion. Principles of operative management.

    PubMed Central

    Smith, B M; Mulherin, J L; Sawyers, J L; Turner, B I; Prager, R L; Dean, R H

    1984-01-01

    Retrohepatic occlusion of the inferior vena cava caused by tumor complicates complete resection and not infrequently is associated with life-threatening symptoms that accelerate the lethality of the underlying malignant process. This report summarizes our experience with caval thrombectomy and reconstruction that allowed complete removal of all gross tumor in seven patients with malignant occlusion of the retrohepatic inferior vena cava. Included in this group are five patients with renal cell carcinoma and extension of tumor into the retrohepatic vena cava. Three of these patients had extension of tumor thrombus into the right atrium. A sixth patient had recurrent right adrenal cortical carcinoma with tumor invasion of the vena cava and occlusion to the right atrium. Associated hepatic vein occlusion and secondary Budd-Chiari syndrome also was successfully managed in this patient. The final patient with occlusion of the entire suprarenal vena cava required caval reconstruction after resection of a primary leiomyosarcoma of the retrohepatic portion of the vena cava. Careful planning of the operative procedure, adequate exposure, complete mobilization of the retrohepatic vena cava, and control of the hepatic venous effluent will allow patients with retrohepatic vena caval occlusions to be managed with safety and success. Images Figs. 1A and B. Fig. 4. Fig. 5. Fig. 6. Fig. 8. PMID:6732311

  11. Left External Iliac and Common Femoral Artery Occlusion Following Blunt Abdominal Trauma without Associated Bone Injury

    PubMed Central

    Byun, Chun Sung; Park, Il Hwan; Do, Hye-jin; Bae, Keum Seok; Oh, Joong Hwan

    2015-01-01

    Blunt abdominal trauma may cause peripheral vascular injuries. However, blunt abdominal trauma rarely results in injuries to the external iliac and common femoral arteries, which often stem from regional bone fractures. Here, we present the case of a patient who had experienced trauma in the lower abdominal and groin area three months before presenting to the hospital, but these injuries did not involve bone fractures and had been managed conservatively. The patient came to the hospital because of left lower leg claudication that gradually became severe. Computed tomography angiography confirmed total occlusion of the external iliac and common femoral arteries. The patient underwent femorofemoral bypass grafting and was discharged uneventfully. PMID:26078931

  12. Caudal mucogingival lesions secondary to traumatic dental occlusion in 27 cats: macroscopic and microscopic description, treatment and follow-up.

    PubMed

    Gracis, Margherita; Molinari, Elena; Ferro, Silvia

    2015-04-01

    The main aim of this retrospective study was to describe clinical and histopathological findings in cats with mucogingival lesions developed at the contact point of the premolar and molar teeth of the opposite quadrant. Cases were retrieved following manual review of the medical records, dental records and photographic documentation of all feline dental patients visited in the period between February 2001 and August 2011. Cats showing different lesions at different times were calculated as multiple cases. A total of 27 cats (31 cases) with 44 lesions (26 proliferations [59%], 11 clefts [25%] and seven foveae [16%]) were included. Mean age at the time of the first visit was 6.6 years. The lesion object of the study was the main reason for presentation in only five cases (16%). Proliferations showed two different histopathological patterns and had characteristics in common with human oral pyogenic granuloma. Successful treatment was achieved in all cases by removing the occlusal contact by dental extraction or coronal reduction, possibly associated with lesion excision. This study underlines the need for a thorough oral examination and evaluation of dental occlusion in all patients. Causes for the development of traumatic occlusion may include an acquired overbite (possibly secondary to selective dental extraction), congenital or post-traumatic malocclusion, abnormal latero-lateral mobility of the mandible, occlusal drift of the premolar and molar teeth, and/or alveolar bone expansion. PMID:25001492

  13. Impairment of Skin Capillary Recruitment Precedes Chronic Complications in Patients with Type 1 Diabetes

    PubMed Central

    Tibirica, Eduardo; Rodrigues, Elba; Cobas, Roberta; Gomes, Marilia B.

    2007-01-01

    Microvascular function in patients with type 1 diabetes without chronic complications was assessed using skin capillary recruitment during post-occlusive reactive hyperemia (PORH). Structural (maximal) capillary density was evaluated during venous occlusion. The study included 48 consecutive outpatients aged 26.3 ± 10.8 years with type 1 diabetes (duration of 9.5 years) without chronic complications and 34 control subjects. Intravital capillary video-microscopy was used in the dynamic study of skin capillaries in the dorsum of the fingers and toes. Capillary recruitment during PORH (% increase in mean capillary density, MCD) was significantly higher in the controls than the patients in both the fingers (p < 0.001) and toes (p < 0.001). During venous occlusion, MCD increase was also higher in the controls than the patients in both the fingers (p < 0.05) and toes (p < 0.0001). In patients, no difference was found between MCD at baseline and after venous occlusion in the fingers but a decrease was observed in the toes (p < 0.001). It is concluded that skin capillary function is significantly impaired in both fingers and toes of patients with type 1 diabetes without chronic complications. Moreover, capillary density during venous occlusion did not increase in either extremity in the patients, suggesting that their capillaries at rest are already maximally recruited. PMID:17823692

  14. Spontaneous Massive Necrosis of Hepatocellular Carcinoma with Narrowing and Occlusion of the Arteries and Portal Veins

    PubMed Central

    Tomino, Takahiro; Yamashita, Yo-ichi; Iguchi, Tomohiro; Itoh, Shinji; Ninomiya, Mizuki; Ikegami, Toru; Yoshizumi, Tomoharu; Soejima, Yuji; Kawanaka, Hirofumi; Ikeda, Tetsuo; Aishima, Shinichi; Shirabe, Ken; Maehara, Yoshihiko

    2014-01-01

    We herein present the case of a 77-year-old man who had fever and right hypochondriac pain. He visited his doctor and underwent contrast computed tomography (CT), and he was suspected to have a liver abscess. He received an antibiotic treatment and his symptoms soon disappeared, but the tumor did not get smaller and its density on contrast CT image got stronger. He underwent biopsy and moderately differentiated hepatocellular carcinoma (HCC) was found. Extended left hepatic and caudate lobectomy was performed. Histological examination showed moderately differentiated HCC with narrowing and occlusion both in the arteries and portal veins associated with mild chronic inflammation. The mechanisms of spontaneous regression of HCC, such as immunological reactions and tumor hypoxia, have been proposed. In our case, histological examination showed the same findings. However, the mechanism is complex, and therefore further investigations are essential to elucidate it. PMID:24926228

  15. Total war

    Microsoft Academic Search

    Talbot Imlay

    2007-01-01

    This article reviews the five volume series, published by Cambridge University Press, on the history of total war from the American Civil War and Wars of German Unification to World War II. The discussion focuses on two questions: how to define total war; and is total war a useful conceptual tool for understanding warfare during this period? Although the editors

  16. Chronic Bronchitis

    MedlinePLUS

    ... More About Us Newsroom Departments & Divisions Locations & Directions Who We Are Connect With Us Contact Us More Chronic Bronchitis ... Information Pediatric Conditions Healthy Lifestyle More About Us Who We Are Newsroom Network of Locations More eNewsletters and More © ...

  17. Chronic Meningitis

    MedlinePLUS

    ... not infections can cause chronic meningitis. They include sarcoidosis and certain disorders that cause inflammation, such as ... For disorders that are not infections, such as sarcoidosis and Behçet syndrome: Corticosteroids or other drugs that ...

  18. Time Management in Acute Vertebrobasilar Occlusion

    SciTech Connect

    Kamper, Lars, E-mail: lars.kamper@helios-kliniken.d [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany); Rybacki, Konrad [University Hospital, Department of Diagnostic Radiology (Germany); Mansour, Michael; Winkler, Sven B.; Kempkes, Udo; Haage, Patrick [University Hospital Witten/Herdecke, Department of Diagnostic and Interventional Radiology, HELIOS Klinikum Wuppertal (Germany)

    2009-03-15

    Acute vertebrobasilar occlusion (VBO) is associated with a high risk of stroke and death. Although local thrombolysis may achieve recanalization and improve outcome, mortality is still between 35% and 75%. However, without recanalization the chance of a good outcome is extremely poor, with mortality rates of 80-90%. Early treatment is a fundamental factor, but detailed studies of the exact time management of the diagnostic and interventional workflow are still lacking. Data on 18 patients were retrospectively evaluated. Time periods between symptom onset, admission to hospital, time of diagnosis, and beginning of intervention were correlated with postinterventional neurological status. The Glasgow Coma Scale and National Institute of Health Stroke Scale (NIHSS) were used to examine patients before and after local thrombolysis. Additionally, multivariate statistics were applied to reveal similarities between patients with neurological improvement. Primary recanalization was achieved in 77% of patients. The overall mortality was 55%. Major complications were intracranial hemorrhage and peripheral embolism. The time period from symptom onset to intervention showed a strong correlation with the postinterventional NIHSS as well as the patient's age, with the best results in a 4-h interval. Multivariate statistics revealed similarities among the patients. Evaluation of time management in acute VBO by multivariate statistics is a helpful tool for definition of similarities in this patient group. Similarly to the door-to-balloon time for acute coronary interventions, the chances for a good outcome depend on a short time interval between symptom onset and intervention. While the only manipulable time period starts with hospital admission, our results emphasize the necessity of efficient intrahospital workflow.

  19. Occlusal morphology of permanent mandibular first and second molars in Gujarati population

    PubMed Central

    Dholia, Bhavik; Manjunatha, Bhari Sharanesha

    2015-01-01

    Background: Dental identification has been used since long time for disaster victim identification protocol. There is a difference of opinion regarding whether ethnicity influences dental morphology or not. Few studies have shown the associations between these dental features and crown traits in humans using quantitative methods. The present study is an attempt to find correlation of occlusal morphology of Gujarati population with forensic Odontology. Aim: To study different occlusal morphology of permanent mandibular first and second molars in Gujarati Population. Materials and Methods: This study comprised of a total of 100 participants of Gujarati origin, selected by random sampling method. Total number of cusps and groove patterns of mandibular first and second molar were examined clinically and photographs of the same were taken. A descriptive statistics, Chi-square test and Student t-test were used for analysis of data. Results: Mandibular first molar with 5 cusps in 71%, 4 cusps in 18% and 6 cusps in 11% were noted in the study. Mandibular first molars with “+” groove pattern in 39.5% and “Y” groove pattern in 60.5% were recorded. Mandibular second molar with 5 cusps in 6.5% and 4 cusps in 93.5% were recorded in the study. Mandibular second molars with “+” groove pattern in 93.5% and “Y” groove pattern in 6.5% were recorded. Conclusion: The most common occlusal morphology in permanent mandibular first molar is “5 cusp” and “Y” groove pattern in about 47% and for second molar is “4 cusp” and “+” groove pattern in 88.5% of Gujarati population. It may be concluded that variation in degree of expression and frequency of teeth in dentitions of different populations is different, which may help in forensic identification. PMID:26005303

  20. Effect of occlusal rehabilitation on spatial memory and hippocampal neurons after long-term loss of molars in rats.

    PubMed

    Sakamoto, S; Hara, T; Kurozumi, A; Oka, M; Kuroda-Ishimine, C; Araki, D; Iida, S; Minagi, S

    2014-10-01

    Experimental loss of occlusal support caused by the extraction or grinding of molar teeth has been reported to foment the impairment of learning and memory in laboratory animals. The purpose of this study was to examine the effect of occlusal reconstruction after long-term loss of molars on spatial memory by using 8-arm radial maze and by assessing histopathological changes of neuron density in the hippocampus. Experimental dentures were inserted into the oral cavities of molarless rats to recover the occlusal support. Age-matched groups of control, molarless and denture-wearing rats were trained to perform the maze tasks. The difference of the error incidence in the maze task was evaluated between three groups. The difference of neuron density between three groups was also evaluated at the end of the maze task. Serum corticosterone levels were also measured to estimate the chronic stress, which could be caused by extraction, insertion of the experimental denture or any experimental procedure. The error incidence in the denture-wearing group was significantly higher than that of the control group, but significantly lower than that of the molarless group. Significant differences of neuron density were observed between three groups in each of the hippocampal CA1, CA3 and DG subfields. No significant difference of the serum corticosterone levels between three groups could be observed. From the results of this study, it was suggested that the recovery of occlusal support would bring amelioration of cognitive impairment concomitant with long period loss of molars in rats. PMID:24909970

  1. Recanalization of Acute and Subacute Venous and Synthetic Bypass-Graft Occlusions With a Mechanical Rotational Catheter

    SciTech Connect

    Wissgott, Christian, E-mail: cwissgott@wkk-hei.de; Kamusella, Peter; Andresen, Reimer [Westkuestenklinikum Heide-Academic Teaching Hospital of the Universities of Kiel, Luebeck and Hamburg, Institute of Diagnostic and Interventional Radiology/Neuroradiology (Germany)

    2013-08-01

    PurposePercutaneous mechanical thrombectomy (PMT) is now established as an alternative treatment of acute arterial occlusions in addition to fibrinolysis and surgical thrombectomy. The objective of this retrospective study was the investigation of a rotational atherothrombectomy catheter in terms of safety and efficacy in the treatment of acute and subacute femoropopliteal bypass occlusions.Materials and MethodsForty-two patients (average age 65.8 {+-} 9.1 years) with acute (<14 days [n = 31]) and subacute (14-42 days [n = 11]) femoropopliteal bypass occlusions were treated consecutively with a rotational debulking and removal catheter (Straub Rotarex). The average occlusion length was 28.4 {+-} 2.9 (24-34) cm. Thirty-four (81 %) patients underwent venous bypass, and 8 (19 %) patients underwent polytetrafluoroethylene bypass.ResultsThe technical success rate was 97.6 % (41 of 42). In 1 patient, blood flow could not be restored despite the use of the atherothrombectomy system. The average catheter intervention time was 6.9 {+-} 2.1 (4-9) min. Ankle-brachial index increased from 0.39 {+-} 0.13 to 0.83 {+-} 0.11 at discharge and to 0.82 {+-} 0.17 after 1 month (p < 0.05). There were a total of 2 (4.8 %) peri-interventional complications: One patient developed a distal embolism, which was successfully treated with local lysis, and another patient had a small perforation at the distal anastomosis, which was successfully treated with a stent.ConclusionPMT with the Rotarex atherothrombectomy catheter represents a safe and effective option in the treatment of acute and subacute femoropopliteal bypass occlusions because it can quickly restore blood flow.

  2. Colonic Varices Due to Chronic Pancreatitis: A Rare Cause of Lower Gastrointestinal Bleeding

    PubMed Central

    Sato, Takahiro; Hirayama, Atsushi

    2015-01-01

    A 75-year-old man with chronic pancreatitis presented with painless bloody stool. Computed tomography revealed a splenic vein occlusion with several collaterals towards the descending colon. Colonoscopy showed tortuous varices in the descending colon, which suggested recent bleeding. Sinistral portal hypertension (SPH) due to chronic pancreatitis was diagnosed, so splenectomy and distal pancreatectomy were performed. Our case illustrates a rare complication of SPH.

  3. Vas deferens occlusion during no-scalpel vasectomy.

    PubMed

    Reynolds, R D

    1994-12-01

    The increasing popularity of the no-scalpel vasectomy (NSV) technique in the United States is driven by patient demand for surgical procedures presumed to be less invasive and by the somewhat lower complication rate of the NSV technique. The NSV technique addresses vasal delivery but not vasal occlusion. Intraluminal red-hot wire cautery with sheath closure over the inguinal end of the cut vas (Schmidt's method) has the lowest failure rate of all reasonable vas occlusion methods. The anatomical relationships of scrotal layers can be unclear during the NSV technique. Accurate identification of the sheath layer is critical to sheath interruption if this method of occlusion is to be used. Placement of an absorbable purse-string suture for sheath interruption during the NSV procedure is described. Special attention must be given to placement of one suture bite in the deep (posterior) sheath wall. The vasal occlusion technique described in this paper blends a refined method of vasal delivery (NSV) with the most effective method of vasal occlusion (cautery with sheath interruption). PMID:7798862

  4. Imaging Natural Occlusal Caries Lesions with Optical Coherence Tomography

    PubMed Central

    Douglas, Shane M.; Fried, Daniel; Darling, Cynthia L.

    2011-01-01

    Several studies have demonstrated that polarization-sensitive optical coherence tomography (PS-OCT) can be used to nondestructively measure the severity of demineralization in the important occlusal surfaces. The purpose of this study was to assess the potential of PS-OCT and OCT methods for the measurement of the depth of natural occlusal carious lesions. Teeth were screened for potential occlusal lesions using near infrared imaging (NIR). A PS-OCT system operating at 1310-nm was used to acquire polarization resolved images of the area of interest on the occlusal surface. The teeth were serial sectioned to 200 ?m thickness and examined with polarized light microscopy (PLM) and Transverse Microradiography (TMR) for comparison. The lesion depth measured nondestructively with PS-OCT was compared to the lesion depth measured with PLM and TMR to assess the performance of these methods and determine if polarization sensitivity is required. The lesion depth measured using OCT correlated well with the lesion depths measured with TMR and PLM. Although polarization sensitivity provided better contrast it was not necessary to have polarization sensitivity to identify deep occlusal lesions. PMID:22228981

  5. Mechanism of vaso-occlusion in sickle cell anemia

    NASA Astrophysics Data System (ADS)

    Lei, Huan; Karniadakis, George

    2012-11-01

    Vaso-occlusion crisis is one of the key hallmark of sickle cell anemia. While early studies suggested that the crisis is caused by blockage of a single elongated cell, recent experimental investigations indicate that vaso-occlusion is a complex process triggered by adhesive interactions among different cell groups in multiple stages. Based on dissipative particle dynamics, a multi-scale model for the sickle red blood cells (SS-RBCs), accounting for diversity in both shapes and cell rigidities, is developed to investigate the mechanism of vaso-occlusion crisis. Using this model, the adhesive dynamics of single SS-RBC was investigated in arterioles. Simulation results indicate that the different cell groups (deformable SS2 RBCs, rigid SS4 RBCs, leukocytes, etc.) exhibit heterogeneous adhesive behavior due to the different cell morphologies and membrane rigidities. We further simulate the tube flow of SS-RBC suspensions with different cell fractions. The more adhesive SS2 cells interact with the vascular endothelium and further trap rigid SS4 cells, resulting in vaso-occlusion in vessels less than 15 ?m . Under inflammation, adherent leukocytes may also trap SS4 cells, resulting in vaso-occlusion in even larger vessels. This work was supported by the NSF grant CBET-0852948 and the NIH grant R01HL094270.

  6. Chronic pancreatitis.

    PubMed

    Nair, Rajasree J; Lawler, Lanika; Miller, Mark R

    2007-12-01

    Chronic pancreatitis is the progressive and permanent destruction of the pancreas resulting in exocrine and endocrine insufficiency and, often, chronic disabling pain. The etiology is multifactorial. Alcoholism plays a significant role in adults, whereas genetic and structural defects predominate in children. The average age at diagnosis is 35 to 55 years. Morbidity and mortality are secondary to chronic pain and complications (e.g., diabetes, pancreatic cancer). Contrast-enhanced computed tomography is the radiographic test of choice for diagnosis, with ductal calcifications being pathognomonic. Newer modalities, such as endoscopic ultrasonography and magnetic resonance cholangiopancreatography, provide diagnostic results similar to those of endoscopic retrograde cholangiopancreatography. Management begins with lifestyle modifications (e.g., cessation of alcohol and tobacco use) and dietary changes followed by analgesics and pancreatic enzyme supplementation. Before proceeding with endoscopic or surgical interventions, physicians and patients should weigh the risks and benefits of each procedure. Therapeutic endoscopy is indicated for symptomatic or complicated pseudocyst, biliary obstruction, and decompression of pancreatic duct. Surgical procedures include decompression for large duct disease (pancreatic duct dilatation of 7 mm or more) and resection for small duct disease. Lateral pancreaticojejunostomy is the most commonly performed surgery in patients with large duct disease. Pancreatoduodenectomy is indicated for the treatment of chronic pancreatitis with pancreatic head enlargement. Patients with chronic pancreatitis are at increased risk of pancreatic neoplasm; regular surveillance is sometimes advocated, but formal guidelines and evidence of clinical benefit are lacking. PMID:18092710

  7. [Chronic hepatitis].

    PubMed

    Figueroa Barrios, R

    1995-01-01

    Medical literature about chronic hepatitis is reviewed. This unresolving disease caused by viruses, drugs or unknown factors may progress to in cirrhosis and hepatocarcinoma. A classification based on liver biopsy histology into chronic persistent and chronic active types has been largely abandoned and emphasis is placed on recognizing the etiology of the various types. One is associated with continuing hepatitis B virus infection; another is related to chronic hepatitis C virus infection and the third is termed autoinmune, because of the association with positive serum autoantibodies. A fourth type with similar clinical functional and morphologic features is found with some drug reactions. Long term corticoesteroid therapy is usually successful in autoinmune type. Associations between antibodies to liver-kidney microsomes and the hepatitis C virus can cause diagnostic difficulties. Antiviral treatment of chronic hepatitis B and C with interpheron alfa is employed, controlling symptoms and abnormal biochemistry and the progression to cirrhosis and liver cancer in 30 to 40% patients. Alternative therapies or combinations with interpheron are being evaluated waiting for final results. PMID:8520023

  8. Chronic urticaria.

    PubMed Central

    Leznoff, A.

    1998-01-01

    OBJECTIVE: To review the pathophysiology of chronic urticaria in light of recent evidence for it being an autoimmune disease, and to recommend appropriate management. QUALITY OF EVIDENCE: An extensive literature review was supplemented with a MEDLINE search. Articles from easily available journals were preferred. These consisted of the most recent basic articles on autoimmunity in relation to chronic urticaria and a selection of previous articles on pathophysiology, which illustrate consistencies with recent evidence. The investigation and management protocol is supported by original and relevant literature. MAIN FINDINGS: The histopathology and immunohistology of chronic urticaria and certain clinical studies were a prelude to definitive evidence that most instances of chronic urticaria are autoimmune. Although allergic and other causes are uncommon, these must be sought because identification can lead to cure or specific treatment. Management of the much more common autoimmune urticaria is based on principles derived from the demonstrated pathogenesis and on results of published clinical trials. CONCLUSIONS: In most instances, chronic urticaria is an autoimmune disease, but uncommon allergic or other causes must be considered. PMID:9805172

  9. Occlusion veineuse rétinienne et syndrome d'hyperviscosité

    PubMed Central

    Younes, Samar; Abdellaoui, Meriem; Zahir, Fadoua; Benatiya, Idriss A; Tahri, Hicham

    2015-01-01

    Les occlusions veineuses rétiniennes secondaires aux syndromes d'hyperviscosité sont rares. Plusieurs cas d'occlusion de la veine centrale de la rétine [OVCR] compliquant une hémopathie ont été décrits, principalement au cours des polycythémies primitives ou secondaires, des lymphomes ou des leucémies. A travers cette observation, nous rapportons le cas d'un patient qui présente une OVCR de l’œil droit survenant dans le cadre d'un myélome multiple. La rétinopathie du syndrome d'hyperviscosité est liée au ralentissement circulatoire qui affecte de manière prépondérante le secteur veineux et donne un aspect de rétinopathie de stase bilatérale, avec dilatation et tortuosité de l'ensemble des veines rétiniennes. A un certain degré d'hyperviscosité, une occlusion veineuse véritable peut survenir. Le traitement comprend la réhydratation, phlébotomie, et plasmaphérèse. PMID:25995806

  10. [Prevention and treatment of hepatic veno-occlusive disease].

    PubMed

    Carreras, Enric

    2011-11-01

    Hematopoietic stem cell transplantation is currently the main cause of hepatic veno-occlusive disease, which is the early complication of this procedure with the highest short-term morbidity and mortality. Given that mortality from severe hepatic veno-occlusive disease can be nearly 100%, the search for measures to prevent of treat this complication is essential. Several risk factors for this complication have been identified and the triggering event that leads to sinusoidal obstruction has been shown to be sinusoidal endothelial cell injury. The present review analyzes measures to avoid or modify the casual risk factors for this complication, as well as the pharmacological agents that can prevent or modify the initial endothelial dysfunction or the resulting sinusoidal occlusion. PMID:21571396

  11. Ambient Occlusion Effects for Combined Volumes and Tubular Geometry

    PubMed Central

    Schott, Mathias; Martin, Tobias; Grosset, A.V. Pascal; Smith, Sean T.; Hansen, Charles D.

    2013-01-01

    This paper details a method for interactive direct volume rendering that computes ambient occlusion effects for visualizations that combine both volumetric and geometric primitives, specifically tube-shaped geometric objects representing streamlines, magnetic field lines or DTI fiber tracts. The algorithm extends the recently presented the directional occlusion shading model to allow the rendering of those geometric shapes in combination with a context providing 3D volume, considering mutual occlusion between structures represented by a volume or geometry. Stream tube geometries are computed using an effective spline-based interpolation and approximation scheme that avoids self-intersection and maintains coherent orientation of the stream tube segments to avoid surface deforming twists. Furthermore, strategies to reduce the geometric and specular aliasing of the stream tubes are discussed. PMID:23559506

  12. [Ophthalmologic diagnostic procedures and imaging of retinal vein occlusions].

    PubMed

    Mirshahi, A; Lorenz, K; Kramann, C; Stoffelns, B; Hattenbach, L-O

    2011-02-01

    Retinal vein occlusions are a common vascular disease of the eye. Ophthalmological diagnostic procedures and imaging are important for the prognosis of the disease, as are the systemic work-up and therapy. Besides routine ophthalmic tests (visual acuity, slit lamp examination, funduscopy) a work-up for glaucoma such as intraocular pressure, visual field or 24 h IOP profile is useful as a diagnostic procedure. Furthermore, new diagnostic and imaging tests such as central corneal thickness and optic nerve head imaging by Heidelberg retina tomography or optical coherence tomography (OCT) should be considered for glaucoma evaluation. Optical coherence tomography also plays a major role in treatment monitoring of macular edema secondary to retinal vein occlusions. Fluorescein angiography is well established and can provide information with regard to size and extent of the occlusion, degree of ischemia, areas of non-perfusion and neovascularization, as well as macular edema. PMID:21331683

  13. Chronic myelogenous leukemia (CML)

    MedlinePLUS

    CML; Chronic myeloid leukemia; Chronic granulocytic leukemia; Leukemia - chronic granulocytic ... nuclear disaster. It takes many years to develop leukemia from radiation exposure. Most people treated for cancer ...

  14. Chronic obstructive pulmonary disease

    MedlinePLUS

    ... airways disease; Chronic obstructive lung disease; Chronic bronchitis; Emphysema; Bronchitis - chronic ... a protein called alpha-1 antitrypsin can develop emphysema. Other risk factors for COPD are: Exposure to ...

  15. The effects of naris occlusion on mouse nasal turbinate development.

    PubMed

    Coppola, David M; Craven, Brent A; Seeger, Johannes; Weiler, Elke

    2014-06-15

    Unilateral naris occlusion, a standard method for causing odor deprivation, also alters airflow on both sides of the nasal cavity. We reasoned that manipulating airflow by occlusion could affect nasal turbinate development given the ubiquitous role of environmental stimuli in ontogenesis. To test this hypothesis, newborn mice received unilateral occlusion or sham surgery and were allowed to reach adulthood. Morphological measurements were then made of paraffin sections of the whole nasal cavity. Occlusion significantly affected the size, shape and position of turbinates. In particular, the nasoturbinate, the focus of our quantitative analysis, had a more delicate appearance on the occluded side relative to the open side. Occlusion also caused an increase in the width of the dorsal meatus within the non-occluded and occluded nasal fossae, compared with controls, and the position of most turbinates was altered. These results suggest that a mechanical stimulus from respiratory airflow is necessary for the normal morphological development of turbinates. To explore this idea, we estimated the mechanical forces on turbinates caused by airflow during normal respiration that would be absent as a result of occlusion. Magnetic resonance imaging scans were used to construct a three-dimensional model of the mouse nasal cavity that provided the input for a computational fluid dynamics simulation of nasal airflow. The simulation revealed maximum shear stress values for the walls of turbinates in the 1 Pa range, a magnitude that causes remodeling in other biological tissues. These observations raise the intriguing possibility that nasal turbinates develop partly under the control of respiratory mechanical forces. PMID:24311813

  16. Functional dental occlusion: an anthropological perspective and implications for practice.

    PubMed

    Kaidonis, J A; Ranjitkar, S; Lekkas, D; Brook, A H; Townsend, G C

    2014-06-01

    Physiologic changes occur in dental occlusion throughout life, resulting from the interplay between functional demands and reciprocating adaptive responses. These changes have been reported in the anthropological literature and they reflect evolutionary changes in the human stomatognathic system during the Paleolithic, hunter-gatherer period. Specific occlusal changes occur in response to different environments, leading to extensive variation within and between extinct and extant human populations. For example, functional demands can cause occlusal and interproximal tooth wear, resulting in shortening of the dental arch, continual tooth eruption and changes in masticatory patterns. Since the advent of farming through to our current industrialized culture, functional demands on the human masticatory system, and its adaptive responses to these demands, have been reduced considerably. Indeed, it is only occasionally that functional demands are severe enough to lead to obvious pathology in the modern human dentition. In contrast to normal masticatory activity, 'modern-day conditions' such as dental caries, periodontal disease and erosion, can lead to significant changes in dental occlusion that are pathological and need to be treated. The masticatory system is a dynamic, functional unit that displays considerable change over a lifetime. In this concept paper, it is proposed that modern human populations living in industrialized environments display dental occlusions that can be considered to be 'neotenous'; that is, our dentitions tend to reflect an unworn stage of our ancestors that was only seen in infants, juveniles and young adults. Clinicians can draw on both phylogenetic and ontogenetic perspectives of 'functional dental occlusion' to differentiate continual physiological changes occurring over time that require ongoing review, from pathological responses that require intervention. PMID:24444303

  17. Use of Trellis thrombectomy system in acute aortofemoral graft occlusion.

    PubMed

    Hanna, Elias B; Gupta, Raghav; Hennebry, Thomas A

    2010-05-01

    Acute aortofemoral graft occlusion is often effectively treated with endovascular therapy but a substantial proportion of patients experience failure or complications of this therapy, and most of them require definitive surgery for the underlying inflow, outflow, or graft disease. We describe a case of an aortofemoral graft occlusion that was successfully treated with the Trellis thrombectomy-thrombolysis system (Covidien, Dublin, Ireland). Subsequent stenting of the graft obviated the need for a definitive graft revision surgery. The Trellis system combines mechanical and local pharmacologic lysis of the thrombus, with more rapid and more effective thrombus dissolution and theoretically less risk of systemic dispersion of the thrombolytic agent and less bleeding. PMID:20155799

  18. Visualisation of urban airborne laser scanning data with occlusion images

    NASA Astrophysics Data System (ADS)

    Hinks, Tommy; Carr, Hamish; Gharibi, Hamid; Laefer, Debra F.

    2015-06-01

    Airborne Laser Scanning (ALS) was introduced to provide rapid, high resolution scans of landforms for computational processing. More recently, ALS has been adapted for scanning urban areas. The greater complexity of urban scenes necessitates the development of novel methods to exploit urban ALS to best advantage. This paper presents occlusion images: a novel technique that exploits the geometric complexity of the urban environment to improve visualisation of small details for better feature recognition. The algorithm is based on an inversion of traditional occlusion techniques.

  19. Permanent Preoperative Carotid Artery Occlusion and Carotid Body Tumor Surgery

    PubMed Central

    Palaskas, Constantine W.; Fisch, Ugo; Valavanis, Anton; Pfaltz, Madeleine

    1993-01-01

    Precise angiographic evaluation of the cerebrovascular system and radiographically controlled balloon occlusion of the internal carotid artery have considerably changed the risk involved with carotid surgery at the skull base. Preoperative permanent balloon occlusion of the internal carotid artery was used in three patients with infiltrative carotid body tumors. Embolization and definitive preoperative control of the carotid artery provided ideal conditions for focusing the surgeon's attention on radical removal of tumor with maximal functional preservation of the adjacent cranial nerves. ImagesFigure 1p23-bFigure 1Figure 2Figure 3Figure 4 PMID:17170886

  20. Limitations of collateral flow after occlusion of a single cortical penetrating arteriole

    E-print Network

    Schaffer, Chris B.

    as a single cortical column (Attwell and Iadecola, 2002). This neurovascular coupling has important scientific neurovascular coupling but also in response to vascular occlusions. In experimental models of occlusion of large

  1. Plasma Concentration of Platelet-Derived Microparticles Is Related to Painful Vaso-Occlusive Phenotype Severity in Sickle Cell Anemia

    PubMed Central

    Nebor, Danitza; Bowers, Andre; Connes, Philippe; Hardy-Dessources, Marie-Dominique; Knight-Madden, Jennifer; Cumming, Vanessa; Reid, Marvin; Romana, Marc

    2014-01-01

    High plasma level of microparticles (MPs) deriving mainly from erythrocytes and platelets has been detected in sickle cell anemia (SCA) patients. Flow cytometry was used to determine the concentration of MPs in two groups of SCA patients exhibiting marked differences in painful vaso-occlusive crisis rates [a non-severe group (n?=?17) and a severe group (n?=?12)], and in a control group composed of healthy subjects (n?=?20). A 3- to 4-fold increase of total MP plasma concentration was detected in SCA patients. Higher platelet-derived MPs concentration was detected in the severe SCA group while erythrocyte-derived MPs concentration was increased in the non-severe SCA patient group only. Our results suggest that plasma concentration of MPs shed by platelets is a biomarker of the vaso-occlusive phenotype-related severity. PMID:24475257

  2. Tracheal Occlusion Conditioning in Conscious Rats Modulates Gene Expression Profile of Medial Thalamus

    PubMed Central

    Bernhardt, Vipa; Hotchkiss, Mark T.; Garcia-Reyero, Natàlia; Escalon, B. Lynn; Denslow, Nancy; Davenport, Paul W.

    2011-01-01

    The thalamus may be the critical brain area involved in sensory gating and the relay of respiratory mechanical information to the cerebral cortex for the conscious awareness of breathing. We hypothesized that respiratory mechanical stimuli in the form of tracheal occlusions would modulate the gene expression profile of the thalamus. Specifically, it was reasoned that conditioning to the respiratory loading would induce a state change in the medial thalamus consistent with a change in sensory gating and the activation of molecular pathways associated with learning and memory. In addition, respiratory loading is stressful and thus should elicit changes in gene expressions related to stress, anxiety, and depression. Rats were instrumented with inflatable tracheal cuffs. Following surgical recovery, they underwent 10?days (5?days/week) of transient tracheal occlusion conditioning. On day 10, the animals were sacrificed and the brains removed. The medial thalamus was dissected and microarray analysis of gene expression performed. Tracheal obstruction conditioning modulated a total of 661 genes (p?occlusions. PMID:21660287

  3. Ear infection - chronic

    MedlinePLUS

    Middle ear infection - chronic; Otitis media - chronic; Chronic otitis media; Chronic ear infection ... Kerschner JE. Otitis media. In: Kliegman RM, Behrman RE, Jenson HB, Stanton BF, eds. Nelson Textbook of Pediatrics. 19th ed. Philadelphia, PA: Saunders ...

  4. Chronic Pancreatitis in Children

    MedlinePLUS

    Chronic Pancreatitis in Children What symptoms would my child have? Frequent or chronic abdominal pain is the most common ... will develop diabetes in adolescence. Who gets chronic pancreatitis? Those at risk for chronic pancreatitis are children ...

  5. Chronic pain - resources

    MedlinePLUS

    Pain - resources; Resources - chronic pain ... The following organizations are good resources for information on chronic pain: American Chronic Pain Association - www.theacpa.org National Fibromyalgia and Chronic Pain Association - www.fmcpaware.org ...

  6. Chronic motor tic disorder

    MedlinePLUS

    Chronic vocal tic disorder; Tic - chronic motor tic disorder ... Chronic motor tic disorder is more common than Tourette syndrome . Chronic tics may be forms of Tourette syndrome. Tics usually start ...

  7. Chronic Kidney Disease (CKD)

    MedlinePLUS

    ... www.kidneyfund.org > Kidney Disease > Chronic Kidney Disease Chronic Kidney Disease (CKD) An estimated 31 million people in the United ... living with chronic kidney disease (CKD). What is CKD? The term “chronic kidney disease” (CKD) means lasting ...

  8. Experimental measurement and prediction of blood flow occlusion achieved using pneumatic tourniquets

    Microsoft Academic Search

    M. J. Breault; D. P. Romilly; B. Graham

    1989-01-01

    The tourniquet pressure at which blood flow occlusion occurs was measured in the laboratory on 34 subjects and correlated with three basic parameters: tourniquet cuff width, limb circumference, and blood pressure. Blood flow occlusion data were also obtained and verified by clinically measuring occlusion pressure on 23 patients in the operating room. Using this data empirical relationships were obtained to

  9. Integrating Context and Occlusion for Car Detection by Hierarchical And-Or Model

    E-print Network

    Zhu, Song Chun

    Integrating Context and Occlusion for Car Detection by Hierarchical And-Or Model Bo Li, , Tianfu Wu context and occlusion for car detec- tion. The And-Or model represents the regularities of car-to-car context and occlusion patterns at three levels: (i) layouts of spatially-coupled N cars, (ii) single cars

  10. Occlusal management for a patient with aural symptoms of unknown etiology: a case report

    Microsoft Academic Search

    Kengo Torii; Ichiro Chiwata

    2007-01-01

    BACKGROUND: Although the discrepancy between the habitual occlusal position (HOP) and the flat bite plate-induced occlusal position (BPOP) (regarded as the muscular physiological reference position) has been recently reported to be related to symptoms of temporomandibular disorders (TMDs), it still remains unclear whether the occlusal equilibration in the reference position is effective to resolve TMD-related discrepancy and symptoms. Aural symptoms

  11. Genome sequence of an Adoxophyes orana granulovirus (AdorGV) occlusion body morphology mutant

    Technology Transfer Automated Retrieval System (TEKTRAN)

    - Genome sequence of an Adoxophyes orana granulovirus (AdorGV) occlusion body morphology mutant Baculoviruses package virus particles in a crystalline matrix of viral protein to form occlusion bodies. Occlusion bodies are used in biological control because the crystalline matrix protects the viral ...

  12. Pulmonary veno-occlusive disease following hematopoietic stem cell transplantation: a rare model of endothelial dysfunction

    Microsoft Academic Search

    M C Bunte; M M Patnaik; M R Pritzker; L J Burns

    2008-01-01

    Veno-occlusive disease is among the most serious complications following hematopoietic stem cell transplantation. While hepatic veno-occlusive disease occurs more commonly, the pulmonary variant remains quite rare and often goes unrecognized antemortem. Endothelial damage may represent the pathophysiologic foundation of these clinical syndromes. Recent advances in the treatment of hepatic veno-occlusive disease may have application to its pulmonary counterpart.

  13. Comparative Evaluation of the Total Hepatitis C Virus Core Antigen, Branched-DNA, and Amplicor Monitor Assays in Determining Viremia for Patients with Chronic Hepatitis C during Interferon Plus Ribavirin Combination Therapy

    Microsoft Academic Search

    Pascal Veillon; Christopher Payan; Gaston Picchio; Michele Maniez-Montreuil; Philippe Guntz; Francoise Lunel

    2003-01-01

    An assay prototype designed to detect and quantify total hepatitis C virus (HCV) core antigen (HCV core Ag) protein in serum and plasma in the presence or absence of anti-HCV antibodies has been recently developed by Ortho-Clinical Diagnostics. The aim of the study was to evaluate the sensitivity, specificity, and reproduc- ibility of the Total HCV core Ag assay in

  14. Dynamic Occlusion and Optical Flow From Corrugated Surfaces

    Microsoft Academic Search

    Nam-Gyoon Kim

    2008-01-01

    Dynamic occlusion (i.e., accretion and deletion of optical texture at the occluding edge) can occur under many different environmental conditions, for example, objects hidden behind other objects when viewed by a moving observer, objects moving in front of other objects, or an observer approaching a brink. Because each of these conditions may require the actor to respond differently, the actor

  15. The Structure of Occlusion in Fourier Space S. S. Beauchemin

    E-print Network

    Barron, John

    The Structure of Occlusion in Fourier Space S. S. Beauchemin Dept. of Computer Science a set of reasonable assumptions, that such distinctions can be made through a Fourier analysis Science The University of Western Ontario London, Canada N6A 5B7 e­mail: barron@csd.uwo.ca Abstract

  16. The Structure of Occlusion in Fourier Space S. S. Beauchemin

    E-print Network

    Beauchemin, Steven S.

    The Structure of Occlusion in Fourier Space S. S. Beauchemin Dept. of Computer Science of reasonable assumptions, that such distinctions can be made through a Fourier analysis of these image events Science The University of Western Ontario London, Canada N6A 5B7 e-mail: barron@csd.uwo.ca Abstract

  17. Feature Point Correspondence in the Presence of Occlusion

    Microsoft Academic Search

    V. Salari; Ishwar K. Sethi

    1990-01-01

    Occlusion and poor feature point detection are two of the main difficulties in the use of multiple frames for establishing correspondence of feature points. A formulation of the correspondence problem as an optimization problem is used to handle these difficulties. Modifications to an existing iterative optimization procedure for solving the formulation of the correspondence problem are discussed. Experimental results are

  18. Learning about Occlusion: Initial Assumptions and Rapid Adjustments

    ERIC Educational Resources Information Center

    Kochukhova, Olga; Gredeback, Gustaf

    2007-01-01

    We examined 6-month-olds' abilities to represent occluded objects, using a corneal-reflection eye-tracking technique. Experiment 1 compared infants' ability to extrapolate the current pre-occlusion trajectory with their ability to base predictions on recent experiences of novel object motions. In the first condition infants performed at asymptote…

  19. Young Infants' Perception of Unity and Form in Occlusion Displays.

    ERIC Educational Resources Information Center

    Johnson, Scott P.; Bremner, J. Gavin; Slater, Alan M.; Mason, Uschi C.; Foster, Kirsty

    2002-01-01

    A recognition-based paradigm was used to investigate possibility that past research failed to sensitively assess infants' perception of the unity of misaligned edges in partial occlusion displays. Results suggested that habituation designs tapping recognition processes may be particularly efficacious in revealing infants' perceptual organization.…

  20. Parent Vessel Occlusion for Vertebrobasilar Fusiform and Dissecting Aneurysms

    Microsoft Academic Search

    R. Leibowitz; M. L. Marcellus; S. D. Chang; G. K. Steinberg; M. P. Marks

    BACKGROUND AND PURPOSE: Previous reports of outcome with permanent vessel occlu- sion (PVO) for large, giant, or fusiform aneurysms in the posterior circulation have been limited. We undertook this study to evaluate the perioperative (within 30 days) and follow-up outcomes for patients treated with permanent occlusion of the vertebral artery for vertebro- basilar fusiform and dissecting aneurysms. METHODS: Thirteen consecutive

  1. Boundary Fragment Matching and Articulated Pose Under Occlusion

    E-print Network

    Howe, Nicholas

    fully visible apart from self­ occlusion of one body part by another. Yet outside of controlled studio], but the use of the EMD embedding here improves on that work by allowing arbitrarily dense sampling], but these do not address partial matching. The use of EMD embedding herein is adapted from work using the shape

  2. Boundary Fragment Matching and Articulated Pose Under Occlusion

    E-print Network

    Howe, Nicholas

    fully visible apart from self- occlusion of one body part by another. Yet outside of controlled studio], but the use of the EMD embedding here improves on that work by allowing arbitrarily dense sampling], but these do not address partial matching. The use of EMD embedding herein is adapted from work using the shape

  3. Improved Reconstruction of Deforming Surfaces by Cancelling Ambient Occlusion

    E-print Network

    Zimmer, Henning

    by a fast approximation to global illumination called ambient occlusion. This allows us to improve- thetic example of deforming skin, where ground truth shape and motion is available. We further, enabling performance capture at the resolution of deforming cloth and skin [1­6]. The goal of these systems

  4. Relationship of difficult forceps delivery to dental arches and occlusion

    Microsoft Academic Search

    Pertti Pirttiniemi; Tuomo Heikkinen

    1994-01-01

    This study examined the relationship between the extensive use of forceps procedures during delivery and later occlusal characteristics. The work uses data collected in National Collaborative Perinatal Research Project (USA), in which more than 60,000 pregnancies and the children's health were followed by regular medical tests and examinations. Of these, a subsample of 2,074 children participated in dental examinations, including

  5. Sex Differences during Visual Scanning of Occlusion Events in Infants

    ERIC Educational Resources Information Center

    Wilcox, Teresa; Alexander, Gerianne M.; Wheeler, Lesley; Norvell, Jennifer M.

    2012-01-01

    A growing number of sex differences in infancy have been reported. One task on which they have been observed reliably is the event-mapping task. In event mapping, infants view an occlusion event involving 1 or 2 objects, the occluder is removed, and then infants see 1 object. Typically, boys are more likely than girls to detect an inconsistency…

  6. MULTIPLE OBJECT TRACKING WITH OCCLUSIONS USING HOG DESCRIPTORS

    E-print Network

    Paris-Sud XI, Université de

    MULTIPLE OBJECT TRACKING WITH OCCLUSIONS USING HOG DESCRIPTORS AND MULTI RESOLUTION IMAGES Piotr build a descriptor based on the Histogram of Oriented Gradients (HOG) [2]. Thirdly, we track feature]. Once, feature points are found, we track them in the next frames comparing their HOG descriptors values

  7. Handling occlusion in object tracking in stereoscopic video sequences

    Microsoft Academic Search

    Eduardo Parrilla; Jaime Riera; Juan-R. Torregrosa; José-L. Hueso

    2009-01-01

    In this paper, we study simple algorithms for three-dimensional tracking objects in a stereo video sequence, by combining optical flow and stereo vision. This method is not able to handle the occlusion of the moving objects when they disappear due to an obstacle. To improve the performance of this method, we propose the use of adaptive filters and neural networks

  8. Strains in the Marginal Ridge During Occlusal Loading

    Microsoft Academic Search

    JEA Palamara; D. Palamara; HH Messer

    2002-01-01

    Background: The marginal ridge is considered fundamental to the ability of the tooth to resist functional and parafunctional occlusal loads without damage. Despite this role, very little is known of patterns of stress and strain in marginal ridges under load. This study investigated strains in proximal enamel of mandibular premolars using finite element analysis (FEA) and strain gauge measurements. Methods:

  9. Computing Visual Correspondence with Occlusions via Graph Cuts

    E-print Network

    Field, David

    and computing disparities. 1 #12;1 Introduction In the last few years, a new class of algorithms for visual new algorithms for visual correspondence based on graph cuts [6, 13, 16] have recently been developed occlusions, while preserv- ing the advantages of graph cut algorithms. We give experimental results

  10. Computing Visual Correspondence with Occlusions via Graph Cuts

    E-print Network

    Field, David

    and computing disparities. 1 #12;1 Introduction In the last few years, a new class of algorithms for visual new algorithms for visual correspondence based on graph cuts [7, 14, 21] have recently been developed occlusions, while preserving the advantages of graph cut algorithms. We give experimental results for stereo

  11. Head movements in the occlusal phase of mastication.

    PubMed

    Matsubara, Nozomu; Hisano, Masataka; Minakuchi, Shunsuke; Soma, Kunimichi

    2002-03-01

    It has been recognized that mandibular movements evoke head movements during jaw tapping. However there have been only a few studies that investigated the aspects of head movements during mastication. The objective of this study was to demonstrate the hypothesis that the head moves actively in mastication in order to achieve effective destruction of a food bolus. Head and mandibular movements during gum, gummi candies and kelp chewing among nine adult volunteers have been recorded as time series data with a three-dimensional motion capture system and the vertical components of the movements have been analyzed. To focus on occlusal phase of mastication, the following parameters have been examined: time lag of the head movements at the beginning of occlusal phase, perpendicular velocity of the head at the beginning of the phase of occlusion, and average velocity of the head during occlusal phase. The results showed that the head moved downward in mastication and the velocity of the head movements increased in the order of gum, gummi candies and kelp chewing. There is a possibility that the elasticity of a food bolus affects the activity of head movements, and the kinetic energy was increased to achieve effective destruction of a food bolus. PMID:12160225

  12. CENTRAL RETINAL VEIN OCCLUSION AFTER SILDENAFIL CITRATE (VIAGRA) USE

    Microsoft Academic Search

    Bassam Nawaiseh; Ahmed Shobaki; Ahmad Hassouneh; Issam Bataineh; Mohamed Al-Jaar

    This is a report of a 31-year old male patient who presented with poor vision of his left eye of one-week duration after the use of two tablets of Sildenafil citrate (Viagra) approximately 24 hours before and 48 hours after the onset of ocular symptoms. Ocular examination was consistent with the diagnosis of central retinal vein occlusion. There was no

  13. Face recognition with contiguous occlusion using markov random fields

    Microsoft Academic Search

    Zihan Zhou; Andrew Wagner; Hossein Mobahi; John Wright; Yi Ma

    2009-01-01

    Partially occluded faces are common in many applica- tions of face recognition. While algorithms based on sparse representation have demonstrated promising results, they achieve their best performance on occlusions that are not spatially correlated (i.e. random pixel corruption). We show that such sparsity-based algorithms can be significantly im- proved by harnessing prior knowledge about the pixel error distribution. We show

  14. Efficient Detection of Occlusion prior to Robust Face Recognition

    PubMed Central

    Dugelay, Jean-Luc

    2014-01-01

    While there has been an enormous amount of research on face recognition under pose/illumination/expression changes and image degradations, problems caused by occlusions attracted relatively less attention. Facial occlusions, due, for example, to sunglasses, hat/cap, scarf, and beard, can significantly deteriorate performances of face recognition systems in uncontrolled environments such as video surveillance. The goal of this paper is to explore face recognition in the presence of partial occlusions, with emphasis on real-world scenarios (e.g., sunglasses and scarf). In this paper, we propose an efficient approach which consists of first analysing the presence of potential occlusion on a face and then conducting face recognition on the nonoccluded facial regions based on selective local Gabor binary patterns. Experiments demonstrate that the proposed method outperforms the state-of-the-art works including KLD-LGBPHS, S-LNMF, OA-LBP, and RSC. Furthermore, performances of the proposed approach are evaluated under illumination and extreme facial expression changes provide also significant results. PMID:24526902

  15. Consequences of retinal image clarity versus occlusion (absent) versus diffusion.

    PubMed Central

    Jampolsky, A

    1994-01-01

    A series of clinical questions and stated hypotheses suggested in the pre-1960s regarding the differences between stimuli of occlusion and diffusion are presented (Part I) and are answered and confirmed by a series of experiments and data in animals and humans. A diffusion stimulus is extremely destructive to development of the acuity system in an eye per se (as well as producing myopia), and a unilateral diffusion stimulus is also destructive to development of the binocular system. Real occlusion is a no-stimulus condition that can be used to preserve normal acuity and binocular development, and as a delay tactic to successfully counteract the detrimental effect of diffusion. Binocular input differences (especially if one is a diffusion stimulus) are a major cause of strabismus in both the immature and mature binocular systems. The hypothesis was proposed that preoperative full-time alternate occlusion in infantile esotropia enhanced the binocularity outcome (for which supportive experimental data in animals and humans from our laboratories are discussed in Part III). Animal experiments during the 1960s and 1970s are reviewed relative to the confusion and conflict generated (Part II), since many of these experiments were based on the false assumptions that the unilateral eyelid closure model was a no-stimulus condition (because of the small amount of light transmitted). In fact, it was a worst-case severe stimulus with both monocular and binocular detrimental consequences. And the unilateral eyelid closure model usually produced either undetected or ignored strabismus in the animal experiments, with such strabismus severely compounding the detrimental effects of the eyelid closure model. Further confusion was added by the amblyopia therapeutic model in animals of "reverse eyelid occlusion" (which was really reverse diffusion) and which the author maintains was a gross distortion of the clinician's real occlusive patch over the better eye in the therapy of amblyopia of the poorer eye. These confusions and conflicts were at variance with long-standing clinical percepts. Part III provides data from the series of animal and human experiments from our laboratories at Smith-Kettlewell Eye Research Institute, which clarify the confusion and conflicts of some of the animal experiments described. Our data support the original hypotheses (Part I) enabling the clinician to use occlusion measures in selected patients to expand the therapeutic timing options and to improve visual outcomes. Binocular system outcomes are shown to be improved by our recent data in animal and human experiments, thus supporting the beneficial sensory effects of preoperative full-time alternate occlusion regimes in infantile esotropia. PMID:7886872

  16. Ultrasound imaging of renal vaso-occlusive events in transgenic sickle mice exposed to hypoxic stress.

    PubMed

    Bonnin, Philippe; Sabaa, Nathalie; Flamant, Martin; Debbabi, Haythem; Tharaux, Pierre Louis

    2008-07-01

    One of the major clinical manifestations of sickle cell disease (SCD) is vaso-occlusive crisis in response to hypoxic exposure, leading to acute and chronic organ damages, especially in kidneys. In a SCD transgenic murine model, ultrasound imaging allowed us to characterize the circulatory changes in renal arteries during vaso-occlusive crisis. Cardiac output, heart rate and renal blood flow velocities (BFV) were measured in 10 male transgenic and 10 male wild-type (WT) mice with a conventional echograph (Vivid 7, GE Medical), before and after hypoxic exposure (8%O(2), 18h). To assess entrapment of red cells, histologic study of the kidneys was performed in both groups. Hypoxic exposure decreased heart rates in both groups (-17%, p < 0.001). Cardiac output remained stable in WT, and decreased in transgenic (-26%, p < 0.01). Peak systolic BFV in the renal artery was not modified in both groups. End-diastolic and mean BFV remained stable in WT, but decreased in sickle transgenic (-56%, p < 0.01 and -47%, p < 0.001, respectively). Transgenic mice displayed marked congestion in peritubular capillaries and glomerular abnormalities with trapped sickle red cells, whereas WT did not present any histologic injury. Five hours after hypoxic exposure, blood flow velocities returned to basal values in both groups. Decrease in end-diastolic and mean BFV in absence of peak systolic BFV after hypoxic exposure strongly indicated that the increase in vascular resistance in kidneys related to sickling of red cells. Thus, ultrasound imaging of the renal artery in mouse is a powerful, noninvasive, easy-to-repeat method to evidence circulatory changes in murine models of vascular renal human diseases. PMID:18258352

  17. Open surgery for chronic limb ischemia: a review.

    PubMed

    Ricco, J B; Thanh Phong, L; Belmonte, R; Schneider, F; Valagier, A; Illuminati, G; Regnault De La Mothe, G

    2013-12-01

    This review considers the role of the different revascularization strategies in patients with chronic limb ischemia (CLI) and reveals that clinical evidence guiding therapeutic decision-making in CLI is poor and only careful basic recommendations can be made. For diffuse aortoiliac disease with occlusion of the aorta, aortobifemoral bypass remains the best option if the patient is fit for open surgery. Unilateral iliac occlusion should be treated by primary stenting, but an iliofemoral bypass may be the best option when the disease extends down to the common and deep femoral arteries. For infrainguinal revascularisation, bypass using the saphenous vein remains the best option for patients with occlusion of the superficial femoral artery >25 cm and for patients with multiple occlusions of the infrapopliteal arteries. In the absence of leg veins, arm veins should be used. Prosthetic grafts are the last option. Endovascular techniques are recommended in patients with short arterial lesions and limited life expectancy <2 years. Finally some patients with CLI are best treated by primary amputation. In conclusion, this review demonstrates that neither an endo- first nor a bypass-first attitude is appropriate in patients with CLI and suggests that these patients should be cared for by specialists in a multidisciplinary center in order to preserve their life and limbs, to conduct clinical trials and to control costs. PMID:24126509

  18. Laser angioplasty with lensed fibers and a holmium:YAG laser in iliac artery occlusions

    NASA Astrophysics Data System (ADS)

    White, Christopher J.; Ramee, Stephen R.; Mesa, Juan E.; Collins, Tyrone J.; Kotmel, Robert; Godfrey, Maureen A.

    1991-05-01

    Holmium-YAG (2.1 (mu) ) laser recanalization was attempted in 10 totally occluded miniature swine iliac arteries using a lensed fiber delivery system. The iliac artery occlusions were created in a Yucatan miniature swine model of atherosclerosis by means of a high cholesterol diet and balloon endothelial denudation. In order to increase the spot size, a spherical silica lens was attached to the distal end of a 300 micrometers core diameter silica optical fiber. The holmium-YAG laser was operated in the free-running mode with 250 microsecond(s) ec pulses at 4 Hz. The energy delivered was 225 mJ per pulse for the 1.0 mm lensed fiber and 200 mJ per pulse for the 1.3 mm lensed fiber. Laser energy was delivered in 2 to 5 second bursts. Successful recanalization was achieved in all 10 arteries attempted without perforation of the arterial wall. The average length of the occlusions was 5.0 +/- 1.8 cm. Following successful laser recanalization significant stenoses (>50%) remained in all of the arteries as judged by angiography. In conclusion, the lensed fibers coupled to the pulsed holmium-YAG laser were safe and effective in recanalizing these difficult lesions in relatively straight iliac arteries. There is potential clinical utility for this system as an adjunct to balloon angioplasty in patients with lesions which are unable to be crossed with guidewires.

  19. Prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension.

    PubMed

    Lee, Noel S; Blanchard, Daniel G; Knowlton, Kirk U; McDivit, Anna M; Pretorius, Victor; Madani, Michael M; Fedullo, Peter F; Kerr, Kim M; Kim, Nick H; Poch, David S; Auger, William R; Daniels, Lori B

    2015-06-01

    This study sought to determine the prevalence of coronary artery-pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and to correlate their presence with the degree of clot burden. CTEPH is a treatable cause of severe pulmonary hypertension and right heart failure. Bronchopulmonary collateral vessels have been used as a supplementary diagnostic and prognostic tool for this disease. Coronary artery-pulmonary artery collaterals in this population have not been described. The coronary angiograms of 300 consecutive patients with CTEPH evaluated for pulmonary thromboendarterectomy (PTE) between January 1, 2007, and May 1, 2014, were examined. Of these patients, 259 (50% male; mean age, 58.3 ± 10.6 years) had cineangiographic images deemed adequate to definitively assess for the presence of coronary artery-pulmonary artery collaterals and were included in the final analyses. Pulmonary angiogram reports were reviewed for extent of pulmonary artery obstruction. The coronary angiograms of 259 age- and sex-matched control patients were also examined. Among 259 CTEPH patients with definitive imaging, 34 coronary artery-pulmonary artery collaterals were found in 28 patients (10.8%), versus 1 coronary artery-pulmonary artery collateral among control subjects (0.4%; P < 0.001). Compared with CTEPH patients without collaterals, patients with collaterals had a significantly higher prevalence of total occlusion of their right or left main pulmonary artery (P < 0.001) or lobar arteries (P < 0.001). In conclusion, the prevalence of coronary artery-pulmonary artery collaterals in CTEPH patients undergoing coronary angiography for possible PTE is approximately 11%. These vessels are associated with more severe pulmonary artery occlusion. PMID:26064456

  20. Prevalence of coronary artery–pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension

    PubMed Central

    Blanchard, Daniel G.; Knowlton, Kirk U.; McDivit, Anna M.; Pretorius, Victor; Madani, Michael M.; Fedullo, Peter F.; Kerr, Kim M.; Kim, Nick H.; Poch, David S.; Auger, William R.; Daniels, Lori B.

    2015-01-01

    Abstract This study sought to determine the prevalence of coronary artery–pulmonary artery collaterals in patients with chronic thromboembolic pulmonary hypertension (CTEPH) and to correlate their presence with the degree of clot burden. CTEPH is a treatable cause of severe pulmonary hypertension and right heart failure. Bronchopulmonary collateral vessels have been used as a supplementary diagnostic and prognostic tool for this disease. Coronary artery–pulmonary artery collaterals in this population have not been described. The coronary angiograms of 300 consecutive patients with CTEPH evaluated for pulmonary thromboendarterectomy (PTE) between January 1, 2007, and May 1, 2014, were examined. Of these patients, 259 (50% male; mean age, 58.3 ± 10.6 years) had cineangiographic images deemed adequate to definitively assess for the presence of coronary artery–pulmonary artery collaterals and were included in the final analyses. Pulmonary angiogram reports were reviewed for extent of pulmonary artery obstruction. The coronary angiograms of 259 age- and sex-matched control patients were also examined. Among 259 CTEPH patients with definitive imaging, 34 coronary artery–pulmonary artery collaterals were found in 28 patients (10.8%), versus 1 coronary artery–pulmonary artery collateral among control subjects (0.4%; P < 0.001). Compared with CTEPH patients without collaterals, patients with collaterals had a significantly higher prevalence of total occlusion of their right or left main pulmonary artery (P < 0.001) or lobar arteries (P < 0.001). In conclusion, the prevalence of coronary artery–pulmonary artery collaterals in CTEPH patients undergoing coronary angiography for possible PTE is approximately 11%. These vessels are associated with more severe pulmonary artery occlusion.

  1. Chronic urticaria.

    PubMed Central

    Burrall, B. A.; Halpern, G. M.; Huntley, A. C.

    1990-01-01

    Urticaria affects 15% to 20% of the population once or more during a lifetime. Chronic urticaria is a frequent recurrent eruption over a period greater than 6 weeks; the cause remains a mystery in more than 75% of cases. Urticaria and angioedema may be produced by immunologic or nonimmunologic means. Urticarial vasculitis, contact urticaria, mastocytosis, physical urticarias, dermatographism, cholinergic urticaria, localized heat urticaria, cold urticaria, aquagenic urticaria, and vibratory angioedema all require specific evaluation and treatment. Chronic idiopathic urticaria is usually controlled by antihistamines; depending on the circadian rhythm of the eruption, sedative or nonsedative antihistamines are prescribed. Some patients will require a combination of H1 and H2 antagonists, or even parenteral corticosteroids. PMID:1970697

  2. Chronic Diseases

    Microsoft Academic Search

    Sharon R. Schatz

    Although diabetes mellitus, cardiovascular disease, and human immunodeficiency virus infection are three separate entities,\\u000a each has causal and non-causal risk factors that are common in the stage 5 chronic kidney disease population. The medical\\u000a nutrition therapies are similar, which emphasize adequate protein and energy intakes, fluid control, and possibly carbohydrate\\u000a and fat modifications. Each patient requires an individualized evaluation, taking

  3. Chronic cough.

    PubMed

    Rai, S P

    2013-05-01

    Chronic cough is often viewed as a difficult clinical problem. It can be physically and psychologically debilitating, occasionally leading to serious complications. Although there are many etiologies, an organized approach including focused history and physical examination, directed testing in select cases, and treatment trials lead to accurate, safe, and cost-effective diagnoses in most patients. Additional symptomatic treatment is frequently beneficial. Occasionally, diagnostic dilemmas, treatment failures, or more serious causative disorders necessitate referral for further testing and management. PMID:24490448

  4. Unilateral horizontal semicircular canal occlusion induces serotonin increase in medial vestibular nuclei: a study using microdialysis in vivo coupled with HPLC-ECD.

    PubMed

    Zhang, Ke; Li, Qian; Xu, Jia; Liu, Junxiu; Ke, Jia; Kang, Wei; Li, Tao; Ma, Furong

    2015-05-18

    Unilateral single semicircular canal occlusion (USSCO) is an effective treatment for some cases of intractable vertigo. All patients suffer behavioural imbalance caused by surgery, and then recover with a resumption of vestibular function. However, the compensation mechanism has not been fully evaluated. Findings suggest that serotonin (5-HT) is released from nerve terminals, and plays a vital role in the plasticity of the central nervous system. In this study, we performed surgery of unilateral single semicircular canal occlusion (USSCO) on guinea pigs, and investigated the change of 5-HT by in vivo microdialysis of the medial vestibular nucleus (MVN) coupled with high-performance liquid chromatography and electrochemical detection (HPLC-ECD). A total of 12 guinea pigs were divided randomly into two groups, namely the USSCO group and the control group. Animals in the USSCO group underwent surgery of lateral horizontal semicircular canal occlusion, and those in the control group experienced the same operation but just to expose the horizontal semicircular canal without occlusion. Vestibular disturbance symptoms were observed in the case of the USSCO group, e.g. head tilting, and forced circular movements and spontaneous nystagmus at postoperative days 1 and 3. The basal level of 5-HT was determined to be 316.78 ± 16.62 nM. It elevated to 448.85 ± 24.56 nM at one day following occlusion (P = 0.001). The increase was completely abolished with the vestibular dysfunction recovery. The results showed that unilateral horizontal semicircular canal occlusion could increase the 5-HT level in MVN. 5-HT may play a significant role in the process of central vestibular compensation with residual vestibular function. PMID:25943376

  5. Radiation-absorbed doses and energy imparted from panoramic tomography, cephalometric radiography, and occlusal film radiography in children

    SciTech Connect

    Bankvall, G.; Hakansson, H.A.

    1982-05-01

    The absorbed doses and energy imparted from radiographic examinations of children, using panoramic tomography (PTG), cephalometric radiography (CPR), and maxillary frontal occlusal overview (FOO), were examined. The absorbed dose at various sites of the head were measured with TL dosimeters in a phantom and in patients. The energy imparted was calculated from measurements of areal exposure using a planparallel ionization chamber. The maximum absorbed doses for panoramic tomography were located around the lateral rotation center, for cephalometric radiography in the left (tube side) parotid region, and for frontal occlusal radiography in the nose. The absorbed doses in the eyes, thyroid gland, and skin are discussed and compared with previous reports and, for the most part, are found to be in agreement. The mean energy imparted from all three examination methods is 5 mJ with about 57 percent from panoramic, 33 percent from cephalometric, and 10 percent from frontal occlusal examinations. The energy imparted from cephalometric radiography can be reduced to about 10 percent with the use of an improved examination technique, leaving panoramic tomography responsible for contributing about 80 percent of the total energy imparted.

  6. Ultrastructural features of masseter muscle exhibiting altered occlusal relationship—a study in a rodent model

    NASA Astrophysics Data System (ADS)

    Lisboa, Marcio V.; Aciole, Gilberth T. S.; Oliveira, Susana C. P. S.; Marques, Aparecida M. C.; Baptista, Abrahão F.; Pinheiro, Antonio L. B.; Aguiar, Marcio C.; Santos, Jean N.

    2010-05-01

    The role of occlusion on Tempormandibular Disorders (TMD) is still unclear, mainly regarding muscular function. The aim of this study was to evaluate the occlusion highlights on masseter ultra morphology. Twenty Wistar rats were randomly divided in four groups: 10 for control group, 10 for occlusal alteration group (CCO). Rats underwent unilateral amputation of the left inferior and superior molar cusps to simulate an occlusal wear situation. The rats of control group had no occlusal wear. Half of the animals of each group was sacrificed in 14 days after the occlusal consuming and half 30 days after the occlusal consuming. The masseter muscles ipsilateral to the amputated molars were excised and processed for light microscopy, electron microscopy. The light microscopy did not show differences between the groups. The electron microscopy was able to detect a degree of intracellular damage in muscle fibers of CCO group: swollen mitochondria with disrupted cristae and cleared matrix, signs of hypercontraction of I bands and myofibril disorganization.

  7. Use of Double-Occlusion Balloon Catheter: Preoperative Portal Vein Embolization for Induction of Future Remnant Liver Hypertrophy

    SciTech Connect

    Kim, Min Joo; Choo, Sung Wook, E-mail: choosw@smc.samsung.co.kr; Do, Young Soo; Park, Kwang Bo; Han, Yoon Hee; Choo, In Wook; Cho, Jae Min [Sungkyunkwan University School of Medicine, 50Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, Department of Radiology, Samsung MedicalCenter (Korea, Republic of); Cho, Jae Won; Kim, Sung Joo; Sohn, Tae Sung [Sungkyunkwan University School of Medicine, 50 Ilwon-Dong, Kangnam-Ku, Seoul, 135-710, Department of General Surgery, SamsungMedical Center (Korea, Republic of)

    2004-01-15

    Purpose: To evaluate the efficacy and safety of using double-occlusion balloon catheters in preoperative portal vein embolization (PVE) to induce future remnant liver hypertrophy. Materials and Methods: PVE was achieved with gelatin sponges by using double-occlusion balloon catheter in seventeen patients with hepatobiliary malignant tumors. The ipsilateral approach was used in thirteen patients and the contralateral approach in four patients due to large size of tumor in the right hepatic lobe.Surgery was performed in 15 patients, 14-27 days (mean, 21.9 days)after PVE. Computed tomographic liver volumetric studies were performed before embolization and before surgery. The changes in aspartate aminotransferase (AST), alanine aminotransferase (ALT), prothrombintime (PT), and total bilirubin levels before and after the PVE were evaluated. Complications were evaluated after PVE. Results: PVE using double-occlusion balloon catheter was successful in all cases, irrespective of approach technique. The future remnant liver (FRL) volumes were 251-920 cm{sup 3} (mean, 437cm{sup 3}) before PVE and 281-1042 cm{sup 3} (mean, 555cm{sup 3}) after PVE. The mean increase in the volume of the FRL was 28.6%; this represented 37% of the pre resection volume of the liver. Clinical and biologic tolerance of PVE was mandatory. There were no complications. Conclusions: PVE using the double-occlusion balloon catheter is safe and well-tolerated and can be performed technically with ease. This hypertrophy allows hepatectomy to be performed safely when the FRL volume is initially insufficient inpatients with hepatobiliary tumors.

  8. A novel LED-based device for occlusal caries detection.

    PubMed

    Aktan, Ali Murat; Cebe, Mehmet Ata; Ciftçi, Mehmet Ertu?rul; Sirin Karaarslan, Emine

    2012-11-01

    The aim of this in-vitro study was to compare the performance of laser-based (DIAGNOdent, KaVo, Biberach, Germany) and LED-based (Midwest Caries I.D., DENTSPLY Professional, New York, USA) caries detectors in the detection of occlusal caries in permanent molars. The study consisted of 129 visually sound or non-cavitated pits or fissures in 82 extracted permanent human molar teeth. Two trained examiners used the laser-based and LED-based caries detectors to examine the fissures for caries. The teeth were then sectioned at the surfaces suspected of containing occlusal caries and histologically evaluated using stereomicroscopy as a gold standard. Inter-examiner reliability of the caries detector examination was assessed using Cohen's Kappa statistics. The sensitivity, specificity, and accuracy in diagnosing occlusal caries using the two devices were calculated according to appropriate cut-off scores. Receiver operating characteristic (ROC) curves were also determined to compare the diagnostic performance of the devices in occlusal caries diagnosis. The cut-off level of significance was taken as p?=?0.005. Cohen's Kappa showed substantial agreement for the laser-based caries detector (0.74), and almost perfect agreement for the LED-based (0.89) caries detector. The specificity of the laser-based device varied from 0.49 to 0.97 at T1 and T2. Its sensitivity varied from 0.33 to 0.65 at T1 and T2. The specificity of the LED-based device varied from 0.48 to 0.56 at T1 and T2. Its sensitivity varied from 0.65 to 0.84 at T1 and from 0.80 to 0.84 at T2. Taking the limitations of the current study into consideration, the DIAGNOdent laser pen was more accurate in determining when teeth were free of occlusal caries than was the Midwest Caries I.D. LED-based device, although the Midwest Caries I.D. device more often revealed the presence of occlusal caries than did the DIAGNOdent pen. PMID:22080431

  9. Optimization of the switch-back technique used for fast occlusion-processing in computer holography

    NASA Astrophysics Data System (ADS)

    Masuda, Sachio; Matsushima, Kyoji; Nakahara, Sumio

    2015-03-01

    A method called the switch-back technique allows us to drastically reduce computation time of occlusion-processing based on the polygon-by-polygon silhouette light-shielding. It is also reported that further reduction of computation time can be achieved by splitting an object to some sub-models along with depth direction. However, computational cost for numerical propagation between the sub-models increases with increasing the number of sub-models. As a result, there is an optimum number of sub-models. In this paper, we propose a technique to predict the optimum number of sub-models by estimating the total computational complexity of the switch-back technique with object splitting.

  10. Paraplegia due to Acute Aortic Coarctation and Occlusion

    PubMed Central

    Park, Chang-Bum; Kim, Min-Ki; Kim, Sang-Hyun

    2014-01-01

    Coarctation and occlusion of the aorta is a rare condition that typically presents with hypertension or cardiac failure. However, neuropathy or myelopathy may be the presenting features of the condition when an intraspinal subarachnoid hemorrhage has compressed the spinal cord causing ischemia. We report two cases of middle-aged males who developed acute non-traumatic paraplegia. Undiagnosed congenital abnormalities, such as aortic coarctation and occlusion, should be considered for patients presenting with nontraumatic paraplegia in the absence of other identifiable causes. Our cases suggest that spinal cord ischemia resulting from acute spinal subarachnoid hemorrhage and can cause paraplegia, and that clinicians must carefully examine patients presenting with nontraumatic paraplegia because misdiagnosis can delay initiation of the appropriate treatment. PMID:24851152

  11. Endobronchial occlusive disease: Nd:YAG or PDT?

    NASA Astrophysics Data System (ADS)

    Regal, Anne-Marie; Takita, Hiroshi

    1991-06-01

    Patients with endobronchial occlusion commonly experience dyspnea, cough, hemoptysis, pneumonitis, and atelectasis. If luminal patency is not re-established, obstructive symptoms may progress to sepsis and death. Although the overall survival of patients with lung cancer may not be altered by relief of airway obstruction, the prognosis for this subset of patients may be improved by eliminating the septic complications of bronchial occlusion. Techniques to treat occluded bronchi include electro-fulguration, cryotherapy, brachytherapy, laser (CO2, Nd-YAG) therapy, and photodynamic therapy (PDT). These represent local forms of treatment and are intended to be palliative. Nd-YAG and PDT are the modalities more frequently utilized in this setting. Comparison of the two treatment forms may furnish insight regarding the appropriate role for each as individual therapies and as part of the armamentarium of cancer therapies.

  12. Branch Retinal Vein Occlusion: Pathogenesis, Visual Prognosis, and Treatment Modalities

    PubMed Central

    Rehak, Jiri; Rehak, Matus

    2008-01-01

    In branch retinal vein occlusion (BRVO), abnormal arteriovenous crossing with vein compression, degenerative changes of the vessel wall and abnormal hematological factors constitute the primary mechanism of vessel occlusion. In general, BRVO has a good prognosis: 50–60% of eyes are reported to have a final visual acuity (VA) of 20/40 or better even without treatment. One important prognostic factor for final VA appears to be the initial VA. Grid laser photocoagulation is an established treatment for macular edema in a particular group of patients with BRVO, while promising results for this condition are shown by intravitreal application of steroids or new vascular endothelial growth factor inhibitors. Vitrectomy with or without arteriovenous sheathotomy combined with removal of the internal limiting membrane may improve vision in eyes with macular edema which are unresponsive to or ineligible for laser treatment. PMID:18293182

  13. [Aneurysm surgery using temporary occlusion under SEP monitoring].

    PubMed

    Sako, K; Nakai, H; Takizawa, K; Tokumitsu, N; Satho, M; Katho, M

    1995-01-01

    Premature rupture of a cerebral aneurysm during operation is a serious hazard. Temporary occlusion of intracranial arteries has emerged as a valuable technical adjunct in the management of intracranial aneurysms. Twenty-five patients (from a group of 43 consecutive aneurysm patients treated during a 13-month period) underwent elective temporary arterial occlusion under somatosensory evoked potential (SEP) monitoring. Median nerve SEPs were used during 19 ICA and MCA aneurysm operations, while posterior tibial SEPs only were used in 7 patients with aneurysm of the ACA. Amplitude of the N20 or P40 was evaluated. A decrease in amplitude more than 50% when compared to baseline value was defined as a significant SEP change. In 11 patients of the 25 cases, SEP changes were observed. Temporary occlusion was applied to the proximal portion of the internal carotid artery 10 times, to the M1 portion of the middle cerebral artery 5 times, to the M1-M2 complex 5 times, to the A1 portion of the anterior cerebral artery 9 times, and to the A2 - A3 once. Of the 26 clipping (25 patients), 12 had SEP alterations, 14 had no SEP changes. Temporary occlusion was released within 3 minutes after disappearance of N20 (or P40) in all the patients with SEP changes except one. Nine of these 11 patients showed complete recovery of SEP and two showed partial recovery. Patients with partial recovery of SEP were associated with postoperative new neurological deficit, which was transient in one of them. There was a correlation between changes in SEP and post operative outcome.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:7845518

  14. Fourier analysis of impedance rheography for peripheral arterial occlusive disease

    Microsoft Academic Search

    Othmar Schuhfried; Günther Wiesinger; Josef Kollmitzer; Christian Mittermaier; Michael Quittan

    2003-01-01

      \\u000a This study identified those harmonics from the frequency spectrum of electrical impedance rheographic signals that discriminate\\u000a between patients with and without peripheral arterial occlusive disease (PAOD). Ninety-four patients with suspected PAOD were\\u000a evaluated by impedance rheography and ankle-arm blood pressure index. The leg with the lower ankle-arm index was used in the\\u000a analysis and a haemodynamically relevant PAOD was

  15. Digital subtraction angiography in pediatric cerebrovascular occlusive disease

    SciTech Connect

    Faerber, E.N.; Griska, L.A.B.; Swartz, J.D.; Capitanio, M.A.; Popky, G.L.

    1984-08-01

    While conventional angiography has been used to demonstrate cerebrovascular occlusive disease in the past, digital subtraction angiography (DSA) is capable of showing progressive vascular involvement with ease, simplicity, and extremely low morbidity, making it particularly well suited for children and outpatients either alone or coordinated with computed tomography. The authors discuss the usefulness and advantages of DSA as demonstrated in 7 infants and children with hemiplegia, 4 of whom had sickle-cell disease.

  16. Tubular Occlusion Optimizes Bonding of Hydrophobic Resins to Dentin

    Microsoft Academic Search

    F. T. Sadek; D. H. Pashley; M. Ferrari; F. R. Tay

    2007-01-01

    Although hydrophobic resins may be bonded to acid-etched dentin with an ethanol wet-bonding technique, the protocol is sensitive to moisture contamination when bonding is performed in deep dentin. This study tested the hypothesis that the use of oxalate or poly(glutamic) acid-modified, diluted ceramicrete (PADC) for dentinal tubule occlusion prevents fluid contamination and improves the bonding of an experimental hydrophobic adhesive

  17. Reproductive factors and lower extremity arterial occlusive disease in women

    Microsoft Academic Search

    Gerold Holzer; Martin A. Koschat; Wolfgang Kickinger; Wolfgang Clementi; Lukas A. Holzer; Markus M. Metka

    2007-01-01

    Background: Reproductive variables affecting sexual hormone levels seem to be significant for atherosclerosis, a major cause of morbidity\\u000a of the vessels of the lower extremities such as lower extremity arterial occlusive disease (LEAOD). We quantify a direct relationship\\u000a between reproductive variables including age at regular and premature menopause and the incidence of severe LEAOD among post-menopausal\\u000a women. Methods and results:

  18. A novel model of occlusive thrombus formation in mice.

    PubMed

    Sasaki, Takeshi; Kuzuya, Masafumi; Cheng, Xian-Wu; Nakamura, Kae; Tamaya-Mori, Norika; Maeda, Keiko; Kanda, Shigeru; Koike, Teruhiko; Sato, Kohji; Iguchi, Akihisa

    2004-11-01

    A novel model to induce occlusive thrombus formation was developed in mice in vivo. Mice were simultaneously treated with ligation and cuff placement at the left carotid artery. At 7 days after the treatment, occlusive thrombus was observed at the intracuff region, but not in the distal and proximal regions of the cuff, and not induced by a single treatment of ligation or cuff placement. The plasma levels of von Willebrand factor (vWF), which represent the endothelial status, were significantly increased in combined treatment of ligation and cuff placement 1 day after the operation. Whereas no significant changes in plasma vWF were observed in either single treatment of ligation or cuff placement. The expression of vWF, considered to be the endothelial marker, was detected on the luminal surface distal and proximal to the cuff and the carotid artery in the single treatment groups treated with either ligation or cuff placement, but was not detected in the intracuff region. Furthermore, the binding of Griffolia Simplicifolia Lectin-I (GSL-I) and endothelial nitric oxide synthase (eNOS) expression indicating the endothelial integrity was not detected in the intracuff region. Intermittent injections of ancrod, which decreases the plasma fibrinogen, inhibited occlusive thrombus formation in the intracuff region. The expression of eNOS was detected at the distal and proximal but not the intracuff region of the carotid artery treated with ancrod. Daily administration of aspirin significantly suppressed the thrombus formation in this model. These results indicate that occlusive thrombus formation accompanied by endothelial damage or dysfunction is induced by the combined application of ligation and cuff placement at the carotid artery, and suggest that this endothelial damage or dysfunction may be one pathogenesis of thrombogenesis in this model. PMID:15334091

  19. Occlusive Dressings and the Healing of Standardized Abrasions

    PubMed Central

    Beam, Joel W

    2008-01-01

    Context: Acute skin trauma during sport participation, resulting in partial-thickness abrasions, is common. The limited investigations focusing on the acute wound environment and dressing techniques and the subsequent lack of evidence-based standards complicate clinical wound care decisions. Objective: To examine the effects of occlusive dressings on healing of standardized, partial-thickness abrasions. Design: Controlled, counterbalanced, repeated-measures design. Setting: University laboratory. Patients or Other Participants: Sixteen healthy women (n ?=? 10) and men (n ?=? 6). Intervention(s): Four standardized, partial-thickness abrasions were inflicted. Film, hydrogel, and hydrocolloid occlusive dressings and no dressing (control) were applied. Participants returned on postwound days 1, 3, 5, 7, 10, and 14 for digital imaging. Wound healing time was measured by change in wound contraction (cm2) and change in wound color (chromatic red) and luminance in red, green, and blue color values. Main Outcome Measure(s): Wound contraction, color (chromatic red), and luminance. Results: A day-by-dressing interaction was found for wound contraction, color, and luminance. Post hoc testing indicated that the film and hydrocolloid dressings produced greater wound contraction than the hydrogel and no dressing on days 7 and 10. Film, hydrogel, and hydrocolloid dressings also resulted in greater wound contraction than the control on day 14. Hydrocolloid dressings produced smaller measures of color and greater measures of luminance than no dressing on day 7. Film, hydrogel, and hydrocolloid dressings also resulted in smaller measures of color and greater measures of luminance compared with no dressing on days 10 and 14. Conclusions: When compared with the control (no dressing), the film, hydrogel, and hydrocolloid occlusive dressings were associated with a faster healing rate of partial-thickness abrasions across time measured by wound contraction, color, and luminance. Overall, these data indicate that occlusive dressings were more effective in healing than no dressing was. PMID:19030138

  20. Branch retinal artery occlusion after thyroid artery interventional embolization

    Microsoft Academic Search

    Feng Wen; Xuemei Chen; Ruiduan Liao

    2000-01-01

    PURPOSE: To report a case of branch retinal artery occlusion after thyroid artery interventional embolization.METHODS: A 33-year-old man with hyperthyroidism complained of visual loss and scotoma in the left eye after thyroid artery interventional embolization. He underwent a full ophthalmologic examination, including fluorescein angiography.RESULTS: Visual acuity was 20\\/25, with inferior and superior scotomas present in the left eye. Fluorescein angiography

  1. Concomitant Occlusive Disease of the Coronary Arteries and Great Vessels

    Microsoft Academic Search

    Thomas J Takach; George J Reul; Denton A Cooley; James J Livesay; J. Michael Duncan; David A Ott; Grady L Hallman

    1998-01-01

    Background. Although an increasing number of elderly and high-risk patients, including those with generalized atherosclerosis, are undergoing coronary revascularization, few reports exist regarding the management of patients who have both occlusive disease of the great vessels and coronary artery disease.Methods. Between 1972 and 1996, 31 consecutive patients (mean age, 56.5 years; 74% men) with multivessel coronary artery disease and symptomatic

  2. [Chronic rhinosinusitis].

    PubMed

    Cuevas, M; Zahnert, T

    2015-06-01

    Chronic Rhinosinusitis (CRS) is a common disease with a major impact on quality of life. Its etiology is multifactorial and the causal pathology is an inflammation and not an infection. The affected region is the nasal mucosa as well as the mucosa of the sinuses. The symptoms are nasal obstruction, nasal discharge (anterior/post nasal drip), facial pain or pressure and/or olfactory disorder for more than 12 weeks. Beside association to hereditary or systemic diseases, CRS can be divided in chronic local findings (e.?g. dental origin, muco- or pyocele, local mycosis, choanal polyp) and general CRS. The latter appears as CRS with nasal polyps or without nasal polyps. According to this, nasal endoscopy combined with investigation for the above mentioned symptoms is essential to diagnose CRS. In order to indicate and plan surgical treatment, CT-scans are necessary. Furthermore, diagnostic tools such as allergy tests, olfactory assessment, laboratory and microbiologic examination, biopsies and tests for aspirin hypersensitivity complete the diagnostic pathway of CRS. The therapeutic approach is local and if necessary oral application of steroids, nasal saline douche and oral long term antibiotics. If this conservative therapy leads to no effect, surgical treatment in terms of functional endoscopic sinus surgery (FESS) has to be considered. PMID:26039039

  3. Cost aggregation and occlusion handling with WLS in stereo matching.

    PubMed

    Min, Dongbo; Sohn, Kwanghoon

    2008-08-01

    This paper presents a novel method for cost aggregation and occlusion handling for stereo matching. In order to estimate optimal cost, given a per-pixel difference image as observed data, we define an energy function and solve the minimization problem by solving the iterative equation with the numerical method. We improve performance and increase the convergence rate by using several acceleration techniques such as the Gauss-Seidel method, the multiscale approach, and adaptive interpolation. The proposed method is computationally efficient since it does not use color segmentation or any global optimization techniques. For occlusion handling, which has not been performed effectively by any conventional cost aggregation approaches, we combine the occlusion problem with the proposed minimization scheme. Asymmetric information is used so that few additional computational loads are necessary. Experimental results show that performance is comparable to that of many state-of-the-art methods. The proposed method is in fact the most successful among all cost aggregation methods based on standard stereo test beds. PMID:18632351

  4. Adaptive filters for depth from stereo and occlusion detection

    NASA Astrophysics Data System (ADS)

    Boughorbel, Faysal

    2008-02-01

    In this paper we present two novel techniques developed in the context of the stereo to multi-view conversion research at Philips in support of the introduction of stereoscopic and auto-stereoscopic. First, we show that we can use a relatively simple filtering approach, based on the recently popular bilateral filters, to address the correspondence problem, which is at the heart of depth and motion estimation. The proposed recursive filter uses Gaussian kernels to filter best matches and to incorporate image-based constraints. It iteratively refines the depth values starting from a random initialization and converges in a limited number of iterations to a time-stable high-quality depth map. The second contribution of the paper is an occlusion detection method that uses robust filtering for the detection of occlusion that is primarily based on the analysis of the variation of the matching metric used in the disparity estimation process. The basic underlying ideas behind the occlusion detection method are (1) that occluded areas are highly likely to be located near image boundaries (where luminance or color changes abruptly), and (2) occluded regions are characterized by a large decrease in the quality of the matching metric across these boundaries. The two algorithms were tested on real-world stereoscopic video content showing promising results.

  5. Stereo matching with Mumford-Shah regularization and occlusion handling.

    PubMed

    Ben-Ari, Rami; Sochen, Nir

    2010-11-01

    This paper addresses the problem of correspondence establishment in binocular stereo vision. We suggest a novel spatially continuous approach for stereo matching based on the variational framework. The proposed method suggests a unique regularization term based on Mumford-Shah functional for discontinuity preserving, combined with a new energy functional for occlusion handling. The evaluation process is based on concurrent minimization of two coupled energy functionals, one for domain segmentation (occluded versus visible) and the other for disparity evaluation. In addition to a dense disparity map, our method also provides an estimation for the half-occlusion domain and a discontinuity function allocating the disparity/depth boundaries. Two new constraints are introduced improving the revealed discontinuity map. The experimental tests include a wide range of real data sets from the Middlebury stereo database. The results demonstrate the capability of our method in calculating an accurate disparity function with sharp discontinuities and occlusion map recovery. Significant improvements are shown compared to a recently published variational stereo approach. A comparison on the Middlebury stereo benchmark with subpixel accuracies shows that our method is currently among the top-ranked stereo matching algorithms. PMID:20847394

  6. Robust Face Alignment Under Occlusion via Regional Predictive Power Estimation.

    PubMed

    Heng Yang; Xuming He; Xuhui Jia; Patras, Ioannis

    2015-08-01

    Face alignment has been well studied in recent years, however, when a face alignment model is applied on facial images with heavy partial occlusion, the performance deteriorates significantly. In this paper, instead of training an occlusion-aware model with visibility annotation, we address this issue via a model adaptation scheme that uses the result of a local regression forest (RF) voting method. In the proposed scheme, the consistency of the votes of the local RF in each of several oversegmented regions is used to determine the reliability of predicting the location of the facial landmarks. The latter is what we call regional predictive power (RPP). Subsequently, we adapt a holistic voting method (cascaded pose regression based on random ferns) by putting weights on the votes of each fern according to the RPP of the regions used in the fern tests. The proposed method shows superior performance over existing face alignment models in the most challenging data sets (COFW and 300-W). Moreover, it can also estimate with high accuracy (72.4% overlap ratio) which image areas belong to the face or nonface objects, on the heavily occluded images of the COFW data set, without explicit occlusion modeling. PMID:25872211

  7. Thrombolysis in ischemic strokes with no arterial occlusion

    PubMed Central

    Lahoti, Sourabh A.; Caplan, Louis R.; Saposnik, Gustavo; Liebeskind, David S.; Gokhale, Sankalp; Hastak, Shirish M.

    2014-01-01

    Rationale Twelve million people develop ischemic stroke each year world over and 30–40% of them do not have arterial occlusions at presentation. Trials conducted to study the efficacy of thrombolytic drug reported better outcome with use of thrombolytic drug but none studied the subtypes of ischemic strokes specifically and adequately. The subgroups of patients with no arterial occlusion at presentation continue to receive thrombolytic therapy without proven benefit and with some risk. Aim The aim of this article is to study whether intravenous thrombolysis with alteplase improves clinical outcome in ischemic stroke patients who do not have arterial occlusion at presentation. Design A retrospective medical record-based observational multicenter, multinational study. Outcomes Primary outcome measure would be clinical outcome at three-months from stroke onset measured by modified Rankin Scale and National Institute of Health Stroke Scale. Secondary outcome measure will be frequency of intracerebral hemorrhage causing worsening of clinical deficit defined as increase in National Institute of Health Stroke Scale by >4. PMID:22863173

  8. Bronchial balloon occlusion in children with complex pulmonary air leaks.

    PubMed

    Hathorn, Claire; Armitage, Nicole; Wensley, David; Seear, Michael

    2013-02-01

    Pulmonary air leaks in children are most commonly due to infection or barotrauma. While cases of severe barotrauma are falling because of advances in neonatal care, the incidence of necrotising pneumonia is rising. The majority of air leaks can be managed conservatively, but more severe cases pose a significant challenge to the clinician. The use of occlusive endobronchial balloons is an established anaesthetic technique for a number of indications, but is not widely used in children. We conducted a review over a 12-year period, and report six cases of complex air leaks in which balloon occlusion was used. Balloon occlusion was successful in both cases of bronchopleural fistulae (secondary to severe necrotising pneumonia) and half of the cases of intrapulmonary air leak (due to barotrauma). In the other two cases (due to barotrauma and filamin A deficiency), it was transiently effective. No serious adverse effects or complications were encountered. In selected cases, endobronchial balloons are a useful adjunct in the management of life-threatening bronchopleural fistulae and cystic lung disease. The procedure is non-operative, minimally invasive and reversible. With the increasing incidence of bronchopleural fistulae, this may become an increasingly important therapy. PMID:23220206

  9. Atropine occlusion in the treatment of strabismic amblyopia and its effect upon the non-amblyopic eye.

    PubMed

    North, R V; Kelly, M E

    1991-04-01

    A total of 189 cases with amblyopia, where atropine sulphate 1% had been used as a method fo unilateral occlusion, were reviewed. The results show that after atropine had been appropriately applied, permanent reversal of amblyopia is rare, and unwanted side-effects are few and of minor nature. Pupil size, light reflex and accommodation of the atropinized eye appear to be unaffected. The angle of squint was unaffected and fixation of the amblyopic eye either remained unchanged or shifted to a more central point. PMID:2062534

  10. Chronic Sinusitis

    PubMed Central

    Steinberg, Johannes; Modi, Pradip

    1990-01-01

    Paranasal sinuses, which communicate with the nasal passages through the sinus ostia, are essentially sterile structures, sterility being maintained by a healthy epithelium with normal actively beating cilia. Irritants, including viruses and bacteria, are trapped in mucus and cilia to allow the clearance of sinuses through the natural ostia into the nasal cavity. Interference with this normal physiological function results in inflammation and infection within the sinus cavities. All of the sinuses are subjected to the same environmental as well as physiological stimuli; thus it is uncommon for a single sinus to be infected and for the others to remain entirely normal. Allergic and non-allergic vasomotor rhinitis should be differentiated from chronic bacterial rhinosinusitis. The understanding of these diseases cannot be separated from the physiological function of the sinus mucosa. PMID:21234027

  11. Haemosiderin-Laden Sputum Macrophages for Diagnosis in Pulmonary Veno-Occlusive Disease

    PubMed Central

    Speich, Rudolf; Treder, Ula; Stricker, Hans; Goede, Jeroen; Ulrich, Silvia; Stämpfli, Simon F.; Breitenstein, Alexander

    2014-01-01

    Aims Pulmonary veno-occlusive disease (PVOD) is a rare condition of pulmonary arterial hypertension (PAH), in which post-capillary veins are affected. Since the therapeutic approach in PVOD differs from other forms of PAH, it is crucial to establish the diagnosis. Due to the fact that affected patients are often hemodynamically unstable, minimal invasive procedures are necessary for the diagnostic work-up. Chronic alveolar haemorrhage has been observed during bronchoalveolar lavage in PVOD cases. This study therefore investigates whether signs of alveolar haemorrhage can also be found in the sputum of these patients. Methods and Results Six patients suffering from PVOD were included in this analysis. As controls, patients with idiopathic PAH (n?=?11), chronic thromboembolic PH (n?=?9) and with sclerodermia-associated PH (n?=?10) were assessed. Sputum from every patient was obtained by a non-invasive manner. The amount of haemosiderin-laden macrophages was determined using the Golde score. There were statistically significant more haemosiderin-laden macrophages in the sputum of patients suffering from PVOD as compared to the other groups (P<0.05). Assuming a cut-off of 200 on the Golde score, all of the 6 PVOD patients surpassed this value compared with only 1 out of the 30 cases with precapillary PH. Thus, sensitivity and specificity with respect to the diagnosis of PVOD was 100% and 97%, respectively. Conclusion The content of haemosiderin-laden macrophages in the sputum of patients suffering from PVOD is significantly higher as compared to other forms of PH and may be useful in the non-invasive diagnostic work-up of these patients. PMID:25501010

  12. Visualization and analysis of occlusion for human jaws using a "functionally generated path"

    NASA Astrophysics Data System (ADS)

    Myszkowski, Karol; Herder, Jens; Kunii, Tosiyasu L.; Ibusuki, Masumi

    1996-03-01

    Dynamic characteristics of occlusion during lower jaw motion are useful in the diagnosis of jaw articulation problems and in computer-aided design/ manufacture of teeth restorations. The Functionally Generated Path (FGP), produced as a surface which envelops the actual occlusal surface of the moving opponent jaw, can be used for compact representation of dynamic occlusal relations. In traditional dentistry FGP is recorded as a bite impression in a patient's mouth. We propose an efficient computerized technique for FGP reconstruction and validate it through implementation and testing. The distance maps between occlusal surfaces of jaws, calculated for multiple projection directions and accumulated for mandibular motion, provide information for FGP computation. Rasterizing graphics hardware is used for fast calculation of the distance maps. Real-world data are used: the scanned shape of teeth and the measured motion of the lower jaw. We show applications of FGP to analysis of the occlusion relations and occlusal surface design for restorations.

  13. In vivo near-IR imaging of occlusal lesions at 1310 nm

    NASA Astrophysics Data System (ADS)

    Fried, Daniel; Staninec, Michal; Darling, Cynthia L.; Lee, Chulsung; Kang, Hobin; Chan, Kenneth H.

    2011-03-01

    Several in vitro studies have demonstrated the potential for transillumination imaging and optical coherence tomography operating at 1310-nm for imaging caries lesions on tooth proximal and occlusal surfaces. Recently, we demonstrated that lesions on proximal surfaces could be imaged in vivo using NIR transillumination and that PS-OCT can be used in vivo to measure early demineralization on tooth buccal and occlusal surfaces. In this paper we report the first in vivo measurements using OCT and NIR imaging of occlusal lesions that have been scheduled for restoration. Occlusal lesions were chosen that were scheduled for restoration based on conventional diagnosis that consists of visual and tactile examination. Occlusal lesions were visible in the NIR. OCT looks promising for confirming the lateral spread of occlusal caries under the dentinal-enamel junction adjacent to fissures. These studies suggest that both near infrared transillumination imaging at 1310-nm and OCT provide valuable information about the severity of caries lesions.

  14. [Chronic wounds as a public health problem].

    PubMed

    Situm, Mirna; Koli?, Maja; Redzepi, Gzim; Antoli?, Slavko

    2014-10-01

    Chronic wounds represent a significant burden to patients, health care professionals and the entire health care system. Regarding the healing process, wounds can be classified as acute or chronic wounds. A wound is considered chronic if healing does not occur within the expected period according to the wound etiology and localization. Chronic wounds can be classified as typical and atypical. The majority of wounds (95 percent) are typical ones, which include ischemic, neurotrophic and hypostatic ulcers and two separate entities: diabetic foot and decubital ulcers. Eighty percent of chronic wounds localized on lower leg are the result of chronic venous insufficiency, in 5-10 percent the cause is of arterial etiology, whereas the rest are mostly neuropathic ulcers. Chronic wounds significantly decrease the quality of life of patients by requiring continuous topical treatment, causing immobility and pain in a high percentage of patients. Chronic wounds affect elderly population. Chronic leg ulcers affect 0.6-3 percent of those aged over 60, increasing to over 5 percent of those aged over 80. Emergence of chronic wounds is a substantial socioeconomic problem as 1-2 percent of western population will suffer from it. This estimate is expected to rise due to the increasing proportion of elderly population along with the diabetic and obesity epidemic. It has been proved that chronic wounds account for the large proportion of costs in the health care system, even in rich societies. Socioeconomically, the management of chronic wounds reaches a total of 2-4 percent of the health budget in western countries. Treatment costs for some other diseases are not irrelevant, nor are the method and materials used for treating these wounds. Considering etiologic factors, a chronic wound demands a multidisciplinary approach with great efforts of health care professionals to treat it more efficiently, more simply and more painlessly for the patient, as well as more inexpensively for health care funds. PMID:25326983

  15. Mechanical thrombectomy using Rotarex system and stent-in-stent placement for treatment of distal femoral artery occlusion secondary to stent fracture – a case report and literature review

    PubMed Central

    Dys, Krzysztof; Drelichowska-Durawa, Justyna; Do?ega-Kozierowski, Bartosz; Lis, Micha?; Sokratous, Kyriakos; Iwanowski, Wojciech; Drelichowski, Stanis?aw; Witkiewicz, Wojciech

    2013-01-01

    Summary Background: Treatment of peripheral arterial diseases may be distinguished into conservative and interventional management; the latter is divided into surgical and endovascular procedures. Management of peripheral artery stenosis and occlusion with vascular stents is associated with the risk of late complications such as restenosis, stent fracture or dislocation. Case Report: A 62-year-old woman with generalized atherosclerosis, particularly extensive in lower limb arteries, was admitted to the Department of Angiology 11 months after having an endovascular procedure performed due to critical ischemia of left lower limb. Because of stent occlusion, a decision to perform angiographic examination of lower limb arteries was made. Examination revealed occlusion of the superficial femoral artery along its entire length, including previously implanted stents. Distal stent was fractured with slight dislocation of the proximal segment. A decision was made to perform mechanical thrombectomy using a Rotarex system followed by a stent-in-stent placement procedure. Follow-up angiography and ultrasound scan performed 24 hours after the procedure revealed a patent vessel with satisfactory blood flow. Discussion: Nowadays, imaging diagnostics of peripheral artery stenosis involves non-invasive examinations such as ultrasound, minimally invasive examinations such as angio-MRI and MDCT, or invasive examinations such as DSA and IVUS. DSA examinations are used to confirm significant stenosis or occlusion of a vessel, particularly when qualifying a patient for endovascular treatment. Due to their anatomic location, the superficial femoral artery and the popliteal artery are subject to various forces e.g. those exerted by the working muscles. Mechanical thrombectomy and atherectomy are efficient methods of arterial recanalization used in the treatment of acute, subacute or even chronic occlusions or stenosis of peripheral vessels. Conclusions: Frequency of angioplasty and vascular stent implantation procedures is increased in patients with peripheral arterial disease, thus increasing the incidence of reported early and late complications such as acute stent thrombosis, restenosis and stent fractures. The Rotarex transcutaneous mechanical thrombectomy system is an efficient method of treating occlusions in arterial stents. It is also safe when performed by experienced operators. PMID:24115965

  16. Artery of Percheron Occlusion in an Elderly Male: A Case Report

    PubMed Central

    Chang, Yuh-Ming; Fan, Yang-Kai

    2015-01-01

    Acute bilateral paramedian thalamic and mesencephalic infarcts are uncommon. Occlusion of the artery of Percheron (AOP) is presumed to cause this specific stroke syndrome. However, occlusion of the AOP is rare and early diagnosis is challenging. Here we described a 70-year-old male patient who presented with acute disturbance of consciousness due to acute bilateral paramedian thalamo-mesencephalic infarction secondary to AOP occlusion. Anticoagulant therapy was administered, and his consciousness gradually improved. PMID:25436032

  17. Computer modeling of occlusal surfaces of posterior teeth with the CICERO CAD\\/CAM system

    Microsoft Academic Search

    Lambert W. Olthoff; Jef M. van der Zel; William J. de Ruiter; Simon T. Vlaar; Frederik Bosman

    2000-01-01

    Statement of Problem: Static and dynamic occlusal interference frequently needs to be corrected by selective grinding of the occlusal surface of conventional cast and ceramic-fused-to-metal restorations. CAD\\/CAM techniques allow control of the dimensional contours of these restorations. However, parameters responsible for the occlusal form need to be determined. In most articulators, these parameters are set as default values. Which technique

  18. Artery of percheron occlusion in an elderly male: a case report.

    PubMed

    Chang, Yuh-Ming; Fan, Yang-Kai

    2015-02-01

    Acute bilateral paramedian thalamic and mesencephalic infarcts are uncommon. Occlusion of the artery of Percheron (AOP) is presumed to cause this specific stroke syndrome. However, occlusion of the AOP is rare and early diagnosis is challenging. Here we described a 70-year-old male patient who presented with acute disturbance of consciousness due to acute bilateral paramedian thalamo-mesencephalic infarction secondary to AOP occlusion. Anticoagulant therapy was administered, and his consciousness gradually improved. PMID:25436032

  19. Prevention of Arteriovenous Shunt Occlusion Using Microbubble and Ultrasound Mediated Thromboprophylaxis

    PubMed Central

    Kutty, Shelby; Wu, Juefei; Hammel, James M.; Abraham, Joseph R.; Venkataraman, Jeeva; Abdullah, Ibrahim; Danford, David A.; Radio, Stanley J.; Lof, John; Porter, Thomas R.

    2014-01-01

    Background Palliative shunts in congenital heart disease patients are vulnerable to thrombotic occlusion. High mechanical index (MI) impulses from a modified diagnostic ultrasound (US) transducer during a systemic microbubble (MB) infusion have been used to dissolve intravascular thrombi without anticoagulation, and we sought to determine whether this technique could be used prophylactically to reduce thrombus burden and prevent occlusion of surgically placed extracardiac shunts. Methods and Results Heparin?bonded ePTFE tubular vascular shunts of 4 mm×2.5 cm (Propaten; W.L Gore) were surgically placed in 18 pigs: a right?sided side?to?side arteriovenous (AV, carotid?jugular) shunt, and a left?sided arterio?arterial (AA, carotid?carotid) interposition shunt in each animal. After shunt implantation, animals were randomly assigned to one of 3 groups. Transcutaneous, weekly 30?minute treatments (total of 4 treatments) of either guided high MI US+MB (Group 1; n=6) using a 3% MRX?801 MB infusion, or US alone (Group 2; n=6) were given separately to each shunt. The third group of 6 pigs received no treatments. The shunts were explanted after 4 weeks and analyzed by histopathology to quantify luminal thrombus area (mm2) for the length of each shunt. No pigs received antiplatelet agents or anticoagulants during the treatment period. The median overall thrombus burden in the 3 groups for AV shunts was 5.10 mm2 compared with 4.05 mm2 in AA (P=0.199). Group 1 pigs had significantly less thrombus burden in the AV shunts (median 2.5 mm2) compared with Group 2 (median 5.6 mm2) and Group 3 (median 7.5 mm2) pigs (P=0.006). No difference in thrombus burden was seen between groups for AA shunts. Conclusion Transcutaneous US with intravenous MB is capable of preventing thrombus accumulation in arteriovenous shunts without the need for antiplatelet agents, and may be a method of preventing progressive occlusion of palliative shunts. PMID:24518555

  20. Use of Nitinol Stents Following Recanalization of Central Venous Occlusions in Hemodialysis Patients

    SciTech Connect

    Rajan, Dheeraj K., E-mail: dheeraj.rajan@uhn.on.ca; Saluja, Jasdeep S. [Toronto General Hospital, University Health Network University of Toronto, Division of Vascular and Interventional Radiology, Department of Medical Imaging (Canada)

    2007-07-15

    Purpose. To retrospectively review the patency of endovascular interventions with nitinol stent placement for symptomatic central venous occlusions in hemodialysis patients. Methods. A retrospective review of all patients who underwent endovascular interventions for dysfunctional hemodialysis grafts and fistulas was performed from April 2004 to August 2006. A total of 6 patients presented with arm and/or neck and facial swelling and left brachiocephalic vein occlusion. The study group consisted of 3 men and 3 women with a mean age of 79.5 years (SD 11.2 years). Of these 6 patients, 1 had a graft and 5 had fistulas in the left arm. The primary indication for nitinol stent placement was technical failure of angioplasty following successful traversal of occluded central venous segments. Patency was assessed from repeat fistulograms and central venograms performed when patients redeveloped symptoms or were referred for access dysfunction determined by the ultrasound dilution technique. No patients were lost to follow-up. Results. Nitinol stent placement to obtain technically successful recanalization of occluded venous segments was initially successful in 5 of 6 patients (83%). In 1 patient, incorrect stent positioning resulted in partial migration to the superior vena cava requiring restenting to prevent further migration. Clinical success was observed in all patients (100%). Over the follow-up period, 2 patients underwent repeat intervention with angioplasty alone. Primary patency was 83.3% (95% CI 0.5-1.2) at 3 months, and 66.7% at 6 and 12 months (0.2-1.1, 0.1-1.2). Secondary patency was 100% at 12 months with 3 patients censored over that time period. Mean primary patency was 10.4 months with a mean follow-up of 12.4 months. No complications related to recanalization of the occluded central venous segments were observed. Conclusion. Our initial experience has demonstrated that use of nitinol stents for central venous occlusion in hemodialysis patients is associated with good mid-term patency and may exceed historical observations with prior use of Wallstents.

  1. Early Experience with the Amplatzer Vascular Plug II for Occlusive Purposes in Arteriovenous Hemodialysis Access

    SciTech Connect

    Powell, Steven, E-mail: Steven.Powell@rlbuht.nhs.uk; Narlawar, Ranjeet; Odetoyinbo, Tolulola; Littler, Peter [Royal Liverpool University Hospital, Department of Interventional Radiology (United Kingdom); Oweis, Deyana [Royal Liverpool University Hospital, Department of Renal Medicine (United Kingdom); Sharma, Ajay; Bakran, Ali [Royal Liverpool Hospital, Department of Transplant Surgery (United Kingdom)

    2010-02-15

    The Amplatzer Vascular Plug Type II (AVP II) has proven effective in the therapeutic embolization of various vascular lesions. It benefits from very rapid occlusion of the target lesion and can be deployed, retrieved, and redeployed if required. There is no literature available on use of the AVP II in the maintenance, closure, and management of complicated arteriovenous access in hemodialysis patients. In this series, we present our clinical experience with the use of the AVP II for embolization of problematic hemodialysis access. The AVP II is a self-expandable Nitinol wire-mesh device. Mounted on a delivery wire it has the capability to be deployed, recaptured, and redeployed. In total seven patients (four males: one diabetic, all nonsmokers), with ages ranging from 44 to 81 years (mean, 63 years), were treated between July 2008 and January 2009. One patient had not started dialysis. The remaining six patients had varied histories, with the time on hemodialysis ranging from 1 to 21 years. Retrospective review of clinical notes revealed patient demographics, type of access, device size, deployment site, and outcomes. Indications for embolization included steal syndrome (one patient), high-flow tributaries (two patients), and limb swelling (four patients). All patients had clinical and sonographical follow-up to 3 months. Surgical ligation had either failed, was considered a contraindication due to concerns regarding wound healing, or was considered difficult due to complex venous anatomy. Only one device was used in each patient, ranging from 6 to 16 mm in diameter. Immediate technical success was seen in 100%. All these patients were followed up clinically in the vascular access radiology clinic at 4 weeks and 3 months. Occlusion of the treated vessel and resolution of symptoms were reconfirmed in 100% of cases at 3 months. It was also noted whether patients were having successful dialysis, if required. There were no complications. Average procedural time was 19 min. We conclude that the AVP II is an efficient, safe, and technically simple occlusion device for use in arteriovenous access.

  2. Interventional treatment for portal venous occlusion after liver transplantation: long-term follow-up results.

    PubMed

    Wang, Jianfeng; Yang, Weili; Huang, Qiang; Gao, Kun; Wei, Baojie; Zhai, Renyou; Shi, Yaoping

    2015-01-01

    Portal vein (PV) occlusion after liver transplant is an uncommon clinical situation, and percutaneous interventional treatment for this condition has not been widely described. The aim of this study was to evaluate the long-term treatment effect of interventional treatment for PV occlusion after liver transplantation (LT). Follow-up data of 13 patients who received interventional treatment for PV occlusion after LT between July 2007 and April 2013 were analyzed. Of these, 10 patients had portal hypertension-related signs and symptoms. Percutaneous balloon angioplasty and stent placement were performed, with percutaneous thrombolysis treatment as appropriate. Embolization therapy was required for significant collateral circulation. Technical and clinical success, complications, and patency of PV were analyzed. Both technical and clinical success was achieved in 11 of the 13 patients (84.6%). Direct portogram showed limited PV occlusion in 7 patients and extensive PV occlusion in 4 patients. The former underwent balloon angioplasty followed by stent placement, while the latter underwent balloon angioplasty followed by stent placement and additional percutaneous thrombolysis treatment. Embolization therapy for collateral circulation was performed in all 4 patients with extensive PV occlusion and 1 patient with limited PV occlusion. All stents remained patency during the follow-up (28.5?±?6.8 months). No portal hypertension-related symptoms reoccurred during follow-up. In conclusion, interventional treatment for PV occlusion after LT showed a high success rate and good long-term results. Comprehensive interventional treatment should be used for extensive PV occlusion. PMID:25634164

  3. Analgesia Evaluation of 2 NSAID Drugs as Adjuvant in Management of Chronic Temporomandibular Disorders

    PubMed Central

    Kurita Varoli, Fernando; Sucena Pita, Murillo; Sato, Sandra; Issa, João Paulo Mardegan; do Nascimento, Cássio

    2015-01-01

    The aim of this triple-blind full-randomized clinical trial was to quantify analgesia in masticatory muscles and temporomandibular joints after occlusal splint therapy associated with the adjuvant administration of nonsteroidal anti-inflammatory drugs (NSAID) isolated or associated with other therapeutic agents. Pain relief was also recorded. Eighteen volunteers who had been suffering from chronic pain in masticatory muscles due to temporomandibular disorders were selected after anamnesis and assessment using RDC/TMD translated to Portuguese. The 3 proposed treatments were NSAID (sodium diclofenac), panacea (sodium diclofenac + carisoprodol + acetaminophen + caffeine), and a placebo. The total treatment duration was 10 days, preceded and succeeded by patients' pain assessment. A washout interval of 11 days was established between each therapy. All participants received all treatments in different moments, in a full randomized crossover methodology. The assessment of drug therapies was performed using visual analogue scale for pain on palpation followed by 11-point numerical scale to quantify pain during treatment. Statistical analysis has shown that, after 10 days of treatment, all therapies were effective for pain relief. NSAID therapy promoted analgesia on the third day, while placebo only promoted analgesia in the eighth day. It has been concluded that sodium diclofenac used as splint adjuvant therapy, promotes significant analgesia in a shorter time. PMID:25874243

  4. Three-Dimensional Vector Analysis of the Human Vestibuloocular Reflex in Response to High-Acceleration Head Rotations II. Responses in Subjects With Unilateral Vestibular Loss and Selective Semicircular Canal Occlusion

    Microsoft Academic Search

    S. T. AW; G. M. HALMAGYI; T. HASLWANTER; I. S. CURTHOYS; R. A. YAVOR; M. J. TODD

    1. We studied the three-dimensional input-output human vestib- uloocular reflex (VOR) kinematics after selective loss of semicir- cular canal ( SCC ) function either through total unilateral vestibular deafferentation (uVD) or through single posterior SCC occlusion (uPCO), and showed large deficits in magnitude and direction in response to high-acceleration head rotations (head \\

  5. Relationship Between Occlusal Plane and Three Levels of Ala Tragus line in Dentulous and Partially Dentulous Patients in Different Age Groups: A Pilot Study

    PubMed Central

    Shaikh, Saquib Ahmed; K, Lekha

    2015-01-01

    Statement of problem: Correct orientation of the occlusal plane plays a vital role in achieving optimal aesthetics, occlusal balance and function of complete dentures. The use of ala tragus line for determination of occlusal plane has been a topic of debate over past many years. Also, the effect of age on level of ala tragal line has not been investigated in the past. Purpose: To determine the effect of age on location of Ala-Tragus line. Materials and Methods: A total of 180 patients (90 males and 90 females) were selected with complete dentition and were grouped according to their age in three age groups with 60 subjects in each age group (Group A: 20-35 y, Group B: 36-50 y, Group C: 51-65 y). Right lateral profile photographs were taken with subjects having fox plane placed intraorally parallel to occlusal plane. Reference points corresponding to inferior border, middle or superior border of tragus and inferior border of ala of nose were marked on photographs. These were joined to get three different levels of Ala-Tragus line. Images were analysed photometrically and most parallel relationship was determined in between arms of fox plane (that represented the occlusal plane) and three different levels of ala tragus line. Data obtained was subjected to statistical analysis using Pearson chi-square and Likelihood-ratio chi-square test. Results: Significant correlation was found between age and level of Ala-Tragus line. The occlusal plane was found to be more parallel to Ala-tragus line when inferior border of tragus was considered as posterior reference point in young adult age group (20-35 y). In older age groups, occlusal plane was found to be more parallel to Ala-tragus line when middle of tragus was considered as posterior reference point. Conclusion: Within the limitations of this study, it can be concluded that a definite relationship exists in between age and level of ala tragus line. PMID:25859523

  6. Robust Lane Sensing and Departure Warning under Shadows and Occlusions

    PubMed Central

    Tapia-Espinoza, Rodolfo; Torres-Torriti, Miguel

    2013-01-01

    A prerequisite for any system that enhances drivers' awareness of road conditions and threatening situations is the correct sensing of the road geometry and the vehicle's relative pose with respect to the lane despite shadows and occlusions. In this paper we propose an approach for lane segmentation and tracking that is robust to varying shadows and occlusions. The approach involves color-based clustering, the use of MSAC for outlier removal and curvature estimation, and also the tracking of lane boundaries. Lane boundaries are modeled as planar curves residing in 3D-space using an inverse perspective mapping, instead of the traditional tracking of lanes in the image space, i.e., the segmented lane boundary points are 3D points in a coordinate frame fixed to the vehicle that have a depth component and belong to a plane tangent to the vehicle's wheels, rather than 2D points in the image space without depth information. The measurement noise and disturbances due to vehicle vibrations are reduced using an extended Kalman filter that involves a 6-DOF motion model for the vehicle, as well as measurements about the road's banking and slope angles. Additional contributions of the paper include: (i) the comparison of textural features obtained from a bank of Gabor filters and from a GMRF model; and (ii) the experimental validation of the quadratic and cubic approximations to the clothoid model for the lane boundaries. The results show that the proposed approach performs better than the traditional gradient-based approach under different levels of difficulty caused by shadows and occlusions. PMID:23478598

  7. Sinusoidal obstruction syndrome (hepatic veno-occlusive disease).

    PubMed

    Fan, Cathy Q; Crawford, James M

    2014-12-01

    Hepatic sinusoidal obstruction syndrome (SOS) is an obliterative venulitis of the terminal hepatic venules, which in its more severe forms imparts a high risk of mortality. SOS, also known as veno-occlusive disease (VOD), occurs as a result of cytoreductive therapy prior to hematopoietic stem cell transplantation (HSCT), following oxaliplatin-containing adjuvant or neoadjuvant chemotherapy for colorectal carcinoma metastatic to the liver and treated by partial hepatectomy, in patients taking pyrrolizidine alkaloid-containing herbal remedies, and in other particular settings such as the autosomal recessive condition of veno-occlusive disease with immunodeficiency (VODI). A central pathogenic event is toxic destruction of hepatic sinusoidal endothelial cells (SEC), with sloughing and downstream occlusion of terminal hepatic venules. Contributing factors are SEC glutathione depletion, nitric oxide depletion, increased intrahepatic expression of matrix metalloproteinases and vascular endothelial growth factor (VEGF), and activation of clotting factors. The clinical presentation of SOS includes jaundice, development of right upper-quadrant pain and tender hepatomegaly, ascites, and unexplained weight gain. Owing to the potentially critical condition of these patients, transjugular biopsy may be the preferred route for liver biopsy to exclude other potential causes of liver dysfunction and to establish a diagnosis of SOS. Treatment includes rigorous fluid management so as to avoid excessive fluid overload while avoiding too rapid diuresis or pericentesis, potential use of pharmaceutics such as defibrotide, coagulolytic agents, or methylprednisolone, and liver transplantation. Proposed strategies for prevention and prophylaxis include reduced-intensity conditioning radiation for HSCT, treatment with ursodeoxycholic acid, and inclusion of bevacizumab with oxaliplatin-based chemotherapeutic regimes. While significant progress has been made in understanding the pathogenesis of SOS and in mitigating against its adverse outcomes, this condition remains a serious complication of a selective group of medical treatments. PMID:25755580

  8. Hereditary chronic pancreatitis

    Microsoft Academic Search

    Jonas Rosendahl; Hans Bödeker; Joachim Mössner; Niels Teich

    2007-01-01

    Hereditary chronic pancreatitis (HCP) is a very rare form of early onset chronic pancreatitis. With the exception of the young age at diagnosis and a slower progression, the clinical course, morphological features and laboratory findings of HCP do not differ from those of patients with alcoholic chronic pancreatitis. As well, diagnostic criteria and treatment of HCP resemble that of chronic

  9. Death After Closed Adolescent Knee Injury and Popliteal Artery Occlusion

    PubMed Central

    Reid, Jeremy J.; Kremen, Thomas J.; Oppenheim, William L.

    2013-01-01

    A healthy adolescent male soccer player sustained a radiograph-negative, effusion-negative physeal injury of the proximal tibia from a ground-level fall with traumatic occlusion of the popliteal artery. Orthopaedic evaluation and arteriography were delayed for 72 hours after the injury. He arrived at a tertiary referral center in multisystem organ failure secondary to lower extremity ischemic necrosis, septic pulmonary thromboembolism, and systemic shock. Emergent medical evaluation, a high index of suspicion, and a careful neurovascular examination are imperative after every closed knee injury in the young athlete. PMID:24427433

  10. [Comparative pharmacoeconomic analysis of prostanoids for peripheral arterial occlusive].

    PubMed

    Avksent'eva, M V; Chupin, A V

    2013-01-01

    Peripheral arteries occlusive disease (PAOD) is a prevalent illness that needs improved pharmacological management, especially for patients not eligible for surgical revascularization. Prostanoids (alprostadil or iloprost) were shown to be effective in PAOD and critical limb ischemia (CLI) but are rather costly. The results of our pharmacoeconomic study (cost estimation based on randomized control trial results) showed that iloprost does not increase cost of treatment when only direct medical costs are taken into account. If indirect costs are included into the analysis iloprost saves up to 27 thousand rubles per patient. Clinical efficacy is still high. Thus iloprost is a better alternative than alprostadil for CLI. PMID:24300486

  11. Catastrophic Antiphospholipid Syndrome Presenting as Bilateral Central Retinal Artery Occlusions

    PubMed Central

    Saraf, Steven S.; Patel, Yogin P.; Desai, Ankit; Desai, Uday R.

    2015-01-01

    A previously healthy 22-year-old African American woman presented with bilateral vision loss associated with headache. Her ocular examination was significant for bilateral retinal arterial “boxcarring,” retinal whitening, retinal hemorrhages, and cherry red spots. She was diagnosed with bilateral central retinal artery occlusions and was hospitalized due to concomitant diagnosis of stroke and hypercoagulable state. She was also found to be in heart failure and kidney failure. Rheumatology was consulted and she was diagnosed with catastrophic antiphospholipid syndrome in association with systemic lupus erythematosus. Approximately 7 months after presentation, the patient's vision improved and remained stable at 20/200 and 20/80. PMID:25722904

  12. An experimental study of tissue damage due to microvascular occlusion 

    E-print Network

    Adams, Bradley Thomas

    1976-01-01

    ABSTRACT An Experimental Study of Tissue Damage Due to Hicrovascular Occlusion, (December 1976) Bradley Thomas Adams, B. S. , Texas AEN University Chairman of Advisory Committee: Dr. William A. Hyman The cheek pouch of the Syrian Golden hamster... of the Syrian Golden hamster (Mesocricetus auratus). The cheek pouch of the hamster has several advantages to its use over other ti ssues ( Dul1ng, 1973). These 1ncl ude: (a) The ease of access and relatively non-traumatic double-layered preparation make 1t...

  13. [An effect of vinpocetine (cavinton) on endothelium function in patients with chronic cerebral ischemia].

    PubMed

    Vaizova, O E; Vengerovski?, A I; Alifirova, V M

    2006-01-01

    The influence of vinpocetine (cavinton) on endothelium function in 87 patients with chronic cerebral ischemia has been studied. Vinpocetine exerts an endothelium protective effect which appears as a partial renewal of endothelium-dependent vasodilatation and inhibition of rejection of Willebrand factor during arteriovenous occlusion test. Leveling of neurological deficit by vinpocetine depends on the extent of renewal of endothelium-dependent vasodilatation. PMID:18196635

  14. [Endothelium-protective effects of vinpocetine, pentoxifylline and enalapril in patients with chronic brain ischemia].

    PubMed

    Vaizova, O E; Vengerovsky, A I; Alifirova, V M

    2011-01-01

    The influence of vinpocetine, pentoxifylline and enalapril on endothelium functions has been studied in a group of in 172 patients with chronic brain ischemia. The endothelium-protective effect of drugs was manifested as the inhibition of the Willebrand factor output during arteriovenous occlusion test and as the renewal of endothelium-depended vasodilation. The extent of neurologic deficit reduction correlated with decrease in the activated endothelium-depended output of the Willebrand factor. PMID:21678652

  15. Occlusion, transparency, and stereopsis: a new explanation for stereo capture.

    PubMed

    Vallortigara, G; Bressan, P

    1994-11-01

    Stereo capture occurs when a regular pattern of repeating elements with zero disparity is superimposed on a disparate subjective figure. The elements enclosed within the subjective contours, but not those outside them, are perceptually captured and pulled on the same depth plane of the disparate figure. The phenomenon has been interpreted as the result either of a spreading of disparity signals from the subjective figure or of the attribution of the depth of certain salient image features to the finer texture elements enclosed in them. We suggest here that, instead, the fact that stereo capture is limited to the texture elements lying within the boundaries of the subjective figure is simply due to ambiguous occlusion information at the monocular level. When the texture elements occlude the inducers of the subjective figure as well, the elements lying outside the boundaries of the subjective figure are also captured. We propose that stereo capture arises as the solution to a conflict between information provided by retinal disparity and occlusion, and show how this effect is related to other previously observed phenomena of conflicting cues to depth. PMID:7975323

  16. Collateral blood flow between left coronary artery bypass grafts and chronically occluded right coronary circulation in patients with triple vessel disease. Observations during complete revascularisation of beating hearts

    Microsoft Academic Search

    Jean-Philippe Verhoye; Issam Abouliatim; Agnes Drochon; Bertand de Latour; Christophe Leclercq; Alain Leguerrier

    2010-01-01

    Objective: Preoperative measurements of collateral blood flow in patients with triple vessel disease and chronic occlusions of the right coronary artery do not, currently, ascertain the need to revascularise an occluded right coronary artery. We performed direct measurements of flow across left coronary bypass grafts to determine their contributions to collateral blood flow. Methods: Collateral blood flow was scored preoperatively

  17. Collateral blood flow between left coronary artery bypass grafts and chronically occluded right coronary circulation in patients with triple vessel disease. Observations during complete revascularisation of beating hearts

    Microsoft Academic Search

    Jean-Philippe Verhoye; Issam Abouliatim; Agnes Drochon; Bertand de Latour; Christophe Leclercq; Alain Leguerrier; Hervé Corbineau

    2007-01-01

    Objective: Preoperative measurements of collateral blood flow in patients with triple vessel disease and chronic occlusions of the right coronary artery do not, currently, ascertain the need to revascularise an occluded right coronary artery. We performed direct measurements of flow across left coronary bypass grafts to determine their contributions to collateral blood flow. Methods: Collateral blood flow was scored preoperatively

  18. EFFETS DE LA MALADIE DE PARKINSON SUR LA RALISATION ACOUSTIQUE DES OCCLUSIVES DU FRANAIS LU

    E-print Network

    Boyer, Edmond

    EFFETS DE LA MALADIE DE PARKINSON SUR LA RÉALISATION ACOUSTIQUE DES OCCLUSIVES DU FRANÇAIS LU'affaiblissement des occlusives en français dans la parole de personnes atteintes de la maladie de Parkinson. Les Parkinson, est influencé par les caractéristiques articulatoires inhérentes des consonnes. Mots

  19. The influence of different occlusive plates on the erythema of hypertrophic burn scars

    Microsoft Academic Search

    Eric Van den Kerckhove; K. H. M. Stappaerts; W. D. Boeckx; F. Staes; B. Van den Hof; S. Monstrey; P. Massagé; J. DeCubber

    2001-01-01

    The purpose of this study was to determine the efficacy of compressing a burn-related hypertrophic scar using different types of occlusive plates (silicone gel, silicone elastomer and plastic). The study was a prospective trial in which 16 burn scars were divided into four areas; each area was then randomly assigned to a different occlusive medium. The dependent variable was erythema

  20. Electronically measured compliance with occlusion therapy for amblyopia is related to visual acuity increase

    Microsoft Academic Search

    Sjoukje E. Loudon; Jan-Roelof Polling; Huibert J. Simonsz

    2003-01-01

    Purpose. We set out to determine whether the children who have low compliance (measured electronically) with occlusion therapy for amblyopia are those with insufficient increase of visual acuity. Methods. In 14 newly identified amblyopic children (mean age 4.3ǃ.9 years), compliance was measured electronically over a period of 1 week, 6 months after the start of occlusion therapy. Compliance was measured

  1. Object Individuation in Infancy: The Use of Featural Information in Reasoning about Occlusion Events.

    ERIC Educational Resources Information Center

    Wilcox, Teresa; Baillargeon, Renee

    1998-01-01

    Eight experiments involving 134 infants aged 7.5 to 11.5 months show that even the youngest give evidence that they use featural information to individuate objects in an occlusion event. When tested with an event-mapping task, even 9.5-month olds give evidence that they can use featural information to interpret an occlusion event as long as the…

  2. Sex Differences in Infants' Mapping of Complex Occlusion Sequences: Further Evidence

    ERIC Educational Resources Information Center

    Wilcox, Teresa

    2007-01-01

    Recently, infant researchers have reported sex differences in infants' capacity to map their representation of an occlusion sequence onto a subsequent no-occlusion display. The research reported here sought to identify the extent to which these sex differences are observed in event-mapping tasks and to identify the underlying basis for these…

  3. Temporal Profile of In Situ DNA Fragmentation After Transient Middle Cerebral Artery Occlusion in the Rat

    Microsoft Academic Search

    Yi Li; Michael Chopp; Ning Jiang; Fayi Yao; Cecylia Zaloga

    1995-01-01

    Summary: We measured the temporal profile and anatomic distribution of cells exhibiting DNA fragmentation at various durations of reperfusion after middle cerebral artery (MCA) occlusion in the rat. Focal cerebral ischemia was induced in male Wistar rats (n = 62) using an intraluminal monofilament blockade of the MCA. After 2 h of MCA occlusion, the animals were killed at different

  4. Angiographic demonstration of non-occlusive hepatic infarction with scintigraphic and microscopic correlation

    Microsoft Academic Search

    Murali Sundaram; Somnuk Srivisal; Julio A. Lagos; Judith E. Ho

    1978-01-01

    The angiographic appearances of histologically proven hepatic infarction without vascular occlusion has not, to our knowledge, been previously described. A case of non-occlusive hepatic infarction in a diabetic patient is presented and correlated with scintigraphic and microscopic findings. It would appear to be the first recorded case of hepatic infarction associated with diabetic ketoacidosis. A follow-up angiogram showed resolution. The

  5. A mathematical analysis of the role of friction in occlusal trauma

    Microsoft Academic Search

    Thomas R. Katona

    2001-01-01

    Statement of Problem. It is recognized that high or misdirected forces can cause occlusal trauma. It is also known that the coefficient of friction between contacting teeth depends on (salivary) lubrication and on the material surfaces in contact. Friction changes the directions and magnitudes of contact forces, but the exact influence of friction on occlusal trauma is unknown. Purpose. The

  6. Endovascular Therapy of Intractable Epistaxis Complicated by Carotid Artery Occlusive Disease

    Microsoft Academic Search

    Robert J. Ernst; Robert V. Bulas; Mary Gaskill-Shipley; Thomas A. Tomsick

    Summary: Three cases of intractable spontaneous posterior ep- istaxis refractory to nasal packing and complicated by ipsilateral carotid artery occlusive disease were successfully treated with internal maxillary artery occlusion with microcoils. There were no complications and no recurrent episodes of epistaxis at a mean follow-up of 12 months. The presence of ipsilateral carotid artery disease requires modification of standard distal

  7. Influence of dental occlusion on physical fitness decline in a healthy Japanese elderly population

    Microsoft Academic Search

    Naoko Okuyama; Takayuki Yamaga; Akihiro Yoshihara; Kaname Nohno; Yutaka Yoshitake; Yasuo Kimura; Mieko Shimada; Naoki Nakagawa; Mamoru Nishimuta; Masaharu Ohashi; Hideo Miyazaki

    2011-01-01

    The aim of this study was to clarify the relationship between dental occlusion and physical fitness by a longitudinal survey. A sample of 348 subjects (171 men and 177 women) aged 71 was investigated by Eichner index (EI) as an occlusal condition (Class A: no loss; Class B: partial loss; Class C: complete loss) and five types of physical fitness

  8. DES OCCLUSIVES ASPIREES EN BASQUE SOULETIN par Jean-Baptiste Coyos

    E-print Network

    Paris-Sud XI, Université de

    DES OCCLUSIVES ASPIREES EN BASQUE SOULETIN par Jean-Baptiste Coyos Si René Lafon a pu dire que "dans les dialectes basques-français, les occlusives sourdes aspirées et les sourdes non aspirées ne les dentales et les dorsales"2. Nicole Moutard, à sa suite, dans sa thèse, au chapitre 9 Le souletin

  9. Embolization with temporary balloon occlusion of the internal carotid or vertebral arteries

    Microsoft Academic Search

    J. Théron; R. Cosgrove; D. Melanson; R. Ethier

    1986-01-01

    Functional vascular anastomoses at the base of the brain allow for temporary occlusion of the carotid or vertebral arteries. Six embolizations with temporary balloon occlusion of the internal carotid or vertebral artery are reported. Polyvinyl alcohol was the embolic material in all cases and all procedures were performed using digital angiography. The size of the embolic particles and the positioning

  10. Clinical Performance of Two Fluorescence-Based Methods in Detecting Occlusal Caries Lesions in Primary Teeth

    Microsoft Academic Search

    R. Matos; T. F. Novaes; M. M. Braga; W. L. Siqueira; D. A. Duarte; F. M. Mendes

    2011-01-01

    This in vivo study aimed to evaluate the performance of 2 fluorescence-based methods in detecting occlusal caries lesions in primary teeth, compared with the performance of visual inspection and radiographic methods, and to propose a mathematic correction of the diagnostic parameters due to the imperfect reference standard method used in the study. Two examiners assessed the occlusal surfaces of 407

  11. Influence of Different Professional Prophylactic Methods on Fluorescence Measurements for Detection of Occlusal Caries

    Microsoft Academic Search

    M. B. Diniz; P. Sciasci; J. A. Rodrigues; A. Lussi; R. C. L. Cordeiro

    2011-01-01

    This study aimed to evaluate the influence of professional prophylactic methods on the DIAGNOdent 2095, DIAGNOdent 2190 and VistaProof performance in detecting occlusal caries. Assessments were performed in 110 permanent teeth at baseline and after bicarbonate jet or prophylactic paste and rinsing. Performance in terms of sensitivity improved after rinsing of the occlusal surfaces when the prophylactic paste was used.

  12. Performance of a new laser fluorescence device for the detection of occlusal caries in vitro

    Microsoft Academic Search

    A. Lussi; E. Hellwig

    2006-01-01

    The new device DIAGNOdent pen based on red laser light induced fluorescence was introduced for the detection of approximal and occlusal caries. The aim of this study was to test its performance on occlusal surfaces. The new device comes with two different sapphire fibre tips: a cylindrical tip and a conical tip. The two new sapphire fibre tips were used

  13. Performance of Conventional and New Methods for the Detection of Occlusal Caries in Deciduous Teeth

    Microsoft Academic Search

    A. Lussi; P. Francescut

    2003-01-01

    The aim of this study was to compare, in vitro, the performance of different conventional diagnostic techniques with the laser-based device, DIAGNOdent, for diagnosis of occlusal caries in deciduous teeth. 95 deciduous teeth with macroscopically intact occlusal surfaces were selected. All teeth were assessed by the following techniques: visual inspection (VI), visual inspection with magnification (VIM), visual inspection combined with

  14. DiagnosticsOcclusal caries detection in primary teeth: a comparison of DIAGNOdent with conventional methods

    Microsoft Academic Search

    P F Ashley; D C Attrill

    2001-01-01

    Objective To compare the accuracy and repeatability of three diagnostic systems (DIAGNOdent, visual and radiographic) for occlusal caries diagnosis in primary molars.Design Two examiner, in vitro, blinded study. Histological gold standard.Materials and methods 58 occlusal surfaces of primary molars examined in turn by two examiners using each of three diagnostic systems (DIAGNOdent, visual and radiographic). These results were compared with

  15. Deciduous teeth occlusal caries detection with 655-nm diode laser confirmed by surface scanning electron microscopy

    Microsoft Academic Search

    Danilo Duarte; Yara P. Fonseca; Fatima A. Zanin; Aldo Brugnera

    2000-01-01

    The morphological complexity of the occlusal surface of deciduous molar teeth is considered as a factor to increase vulnerability to caries lesion. Occlusal surface of these teeth shows sulcus, pits and fissures which allow retention of both micro-organisms and food debris which make them more susceptible to caries. In the last decades there was a significant reduction on caries of

  16. Comparison between Visual Examination and a Laser Fluorescence System for in vivo Diagnosis of Occlusal Caries

    Microsoft Academic Search

    E. C. Sheehy; S. R. Brailsford; E. A. M. Kidd; D. Beighton; L. Zoitopoulos

    2001-01-01

    This study compared a laser fluorescence (LF) system (DIAGNOdent) with a visual caries scoring system for in vivo detection and diagnosis of occlusal caries under the conditions of an epidemiological study, in 132 mandibular and 38 maxillary first permanent molars in 170 children (mean age: 6.85 ± 0.58 years). The teeth were cleaned and occlusal caries status in a selected

  17. Occlusal Force and Condylar Motion in Patients with Anterior Open Bite

    Microsoft Academic Search

    S. Miyawaki; Y. Araki; Y. Tanimoto; A. Katayama; A. Fujii; M. Imai; T. Takano-Yamamoto

    2005-01-01

    Patients with open bite often show a weak occlusal force and temporomandibular disorders (TMDs). If these are the main cause of open bite, it may be hypothesized that both pre-pubertal and adult open-bite patients would show a weak occlusal force and abnormal condylar motion. The purpose of this study was to test this hypothesis. Test group subjects consisted of 13

  18. Positive intrapulmonary oncotic pressure enhances short-term lung growth acceleration after fetal tracheal occlusion

    Microsoft Academic Search

    Alexander Dzakovic; Amir Kaviani; Russell W. Jennings; Jay M. Wilson; Dario O. Fauza

    2002-01-01

    Purpose: This study was aimed at determining whether positive oncotic pressure induced in the fetal lung liquid could safely maximize accelerated lung growth after tracheal occlusion. Methods: Fetal lambs (n = 21) were divided into 4 groups: group I (n = 5) consisted of sham-operated controls; group II (n = 5) underwent simple tracheal occlusion (TO); group III (n =

  19. Use of digital photography in the reconstruction of the occlusal plane orientation

    Microsoft Academic Search

    Marko Guberina; Robert ?eli?; Robert Antoni?

    Aim This study evaluated whether the occlusal plane measure- ments on digital photographs were reliable for the reconstruction of occlusal plane. Methods Forty-two subjects (25 female and 17 male subjects, aged 19 to 30 years) with all teeth and Angle Class I participated. Irreversible hydrocolloid impressions were made and the casts were poured in dental stone (ISO Type I) and

  20. To appear in: The International Journal of Computer Vision Large Occlusion Stereo

    E-print Network

    To appear in: The International Journal of Computer Vision Large Occlusion Stereo Aaron F. Bobick Institute of Technology 20 Ames St., Cambridge MA 02139 Abstract: A method for solving the stereo matching | is de ned to facilitate the description of the e ects of occlusion on the stereo matching process

  1. Neurologic and Neuropathologic Outcome After Middle Cerebral Artery Occlusion in Rats

    Microsoft Academic Search

    Lennart Persson; Hans-Goran Hardemark; Hans G. Bolander; Lars Hillered; Yngve Olsson

    2010-01-01

    Focal cerebral ischemia was produced in 45 rats by occlusion of the left middle cerebral artery. Groups of rats were investigated over a long period after occlusion, that is, from a few hours to 42 days after the production of focal ischemia. Light microscopy showed infarcts in the frontoparietal cortex and the lateral caudoputamen. The ischemic changes closely resembled those

  2. Diagnostic Values of Laser Fluorescence Device Compared to Other Techniques in Occlusal Caries Detection

    Microsoft Academic Search

    M. Biria; M. Moshfeghi; A. Akbarzadeh Baghban; A. Chehresaz

    2009-01-01

    Objective: The aim of the present study was to compare the performance of laser fluores- cence (LF) method with other conventional diagnostic techniques in detection of small occlusal caries in permanent teeth. Materials and Methods: Prior to this in vitro diagnostic study, a pilot study assessed in- tra-examiner reliability and reproducibility. The occlusal surfaces of 90 extracted human premolars were

  3. LES OCCLUSIONS INTESTINALES CHEZ L'ADULTE INTÉRET DE LA TOMODENSITOMÉTRIE

    Microsoft Academic Search

    K. LEBBAR; D. BASSOU; M. DRISSI; T. AMIL; M. BENAMEUR

    SUMMARY Adult intestinal occlusion. Interest of CT scan. Intestinal occlusions are frequent. Complete c l i n i c a l p i c t u re is inconstant. CT scan high resolution is a method of first intention. It allows to positi ve topo gra- phic and etiologic diagnosis. It also estimates the de gree of intestinal suffering.

  4. Effects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion

    E-print Network

    Duong, Timothy Q.

    occlusion (MCAO) model in rats. In experiment 1, DMSO treatment (1.5 g/kg intravenously over 3 h) reducedEffects of intravenous dimethyl sulfoxide on ischemia evolution in a rat permanent occlusion model of Heidelberg, Heidelberg, Germany Dimethyl sulfoxide (DMSO) has a variety of biological actions that suggest

  5. Case report: radial artery occlusion post-radial angiogram in essential thrombocytosis.

    PubMed

    Chow, C L; Mutha, V; Farouque, O

    2015-04-01

    Coronary angiographies that are performed via the radial artery generally have lower bleeding complications, however, patients are at risk of radial artery occlusion, with resultant digital ischaemia. This report describes a case of digital ischaemia after transradial coronary angiography in a patient with essential thrombocytosis. Risk factors for thrombo-occlusive complications, and potential prevention strategies are also explored. PMID:25613239

  6. Important Factors for the Hearing Loss Caused by the Triple Semicircular Canal Occlusion in Guinea Pigs

    Microsoft Academic Search

    Shankai Yin; Dongzhen Yu; Zhengnong Chen; Zhenyu Cao; Jian Wang

    2007-01-01

    Hypothesis: Dynamic recording of the auditory brainstem response is helpful in verifying harmful procedure(s) to hear- ing during triple semicircular canal occlusion (TSCO) surgery. The damage to the membranous semicircular labyrinth is the single major contributor to hearing loss caused by TSCO. Background: Posterior semicircular canal occlusion has been recognized as an efficient method of eliminating vertigo with- out causing

  7. Effect of Experimentally Induced Occlusal Trauma on Substance P Expression in Human Dental Pulp and Periodontal Ligament

    Microsoft Academic Search

    Javier Caviedes-Bucheli; Maria Mercedes Azuero-Holguin; Jose Antonio Correa-Ortiz; Marco Vinicio Aguilar-Mora; James Dario Pedroza-Flores; Esteban Ulate; Nelson Lombana; Hugo Roberto Munoz

    2011-01-01

    IntroductionThe purpose of this study was to quantify the effect of occlusal trauma experimentally induced with occlusal interferences on substance P (SP) expression in healthy human dental pulp and periodontal ligament.

  8. A Microarray Study of Middle Cerebral Occlusion Rat Brain with Acupuncture Intervention

    PubMed Central

    Zhang, Chao; Wen, Yan; Fan, Xiaonong; Yang, Sha; Tian, Guang; Zhou, Xueyi; Chen, Yaqiong; Meng, Zhihong

    2015-01-01

    Microarray analysis was used to investigate the changes of gene expression of ischemic stroke and acupuncture intervention in middle cerebral artery occlusion (MCAo) rat brain. Results showed that acupuncture intervention had a remarkable improvement in neural deficit score, cerebral blood flow, and cerebral infarction volume of MCAo rats. Microarray analysis showed that a total of 627 different expression genes were regulated in ischemic stroke. 417 genes were upregulated and 210 genes were downregulated. A total of 361 different expression genes were regulated after acupuncture intervention. Three genes were upregulated and 358 genes were downregulated. The expression of novel genes after acupuncture intervention, including Tph1 and Olr883, was further analyzed by Real-Time Quantitative Polymerase Chain Reaction (RT-PCR). Upregulation of Tph1 and downregulation of Olr883 indicated that the therapeutic effect of acupuncture for ischemic stroke may be closely related to the suppression of poststroke depression and regulation of olfactory transduction. In conclusion, the present study may enrich our understanding of the multiple pathological process of ischemic brain injury and indicate possible mechanisms of acupuncture on ischemic stroke. PMID:25861363

  9. Fusiform Aneurysm on the Basilar Artery Trunk Treated with Intra-Aneurysmal Embolization with Parent Vessel Occlusion after Complete Preoperative Occlusion Test

    PubMed Central

    Jung, Young-Jin; Kim, Min-Soo; Choi, Byung-Yon

    2013-01-01

    Fusiform aneurysms on the basilar artery (BA) trunk are rare. The microsurgical management of these aneurysms is difficult because of their deep location, dense collection of vital cranial nerves, and perforating arteries to the brain stem. Endovascular treatment is relatively easier and safer compared with microsurgical treatment. Selective occlusion of the aneurysmal sac with preservation of the parent artery is the endovascular treatment of choice. But, some cases, particularly giant or fusiform aneurysms, are unsuitable for selective sac occlusion. Therefore, endovascular coiling of the aneurysm with parent vessel occlusion is an alternative treatment option. In this situation, it is important to determine whether a patient can tolerate parent vessel occlusion without developing neurological deficits. We report a rare case of fusiform aneurysms in the BA trunk. An 18-year-old female suffered a headache for 2 weeks. Computed tomography and magnetic resonance image revealed a fusiform aneurysm of the lower basilar artery trunk. Digital subtraction angiography revealed a 7.1×11.0 mm-sized fusiform aneurysm located between vertebrovasilar junction and the anterior inferior cerebellar arteries. We had good clinical result using endovascular coiling of unruptured fusiform aneurysm on the lower BA trunk with parent vessel occlusion after confirming the tolerance of the patient by balloon test occlusion with induced hypotension and accompanied by neurophysiologic monitoring, transcranial Doppler and single photon emission computed tomography. In this study, we discuss the importance of preoperative meticulous studies for avoidance of delayed neurological deficit in the patient with fusiform aneurysm on lower basilar trunk. PMID:23826480

  10. Mesenteric Vascular Occlusion: Comparison of Ancillary CT Findings between Arterial and Venous Occlusions and Independent CT Findings Suggesting Life-Threatening Events

    PubMed Central

    Wu, Cheng-Hsien; Wang, Li-Jen; Chen, Huan-Wu; Lin, Being-Chuan; Huang, Chen-Chih

    2013-01-01

    Objective To compare the ancillary CT findings between superior mesenteric artery thromboembolism (SMAT) and superior mesenteric vein thrombosis (SMVT), and to determine the independent CT findings of life-threatening mesenteric occlusion. Materials and Methods Our study was approved by the institution review board. We included 43 patients (21 SMAT and 22 SMVT between 1999 and 2008) of their median age of 60.0 years, and retrospectively analyzed their CT scans. Medical records were reviewed for demographics, management, surgical pathology diagnosis, and outcome. We compared CT findings between SMAT and SMVT groups. Multivariate analysis was conducted to determine the independent CT findings of life-threatening mesenteric occlusion. Results Of 43 patients, 24 had life-threatening mesenteric occlusion. Death related to mesenteric occlusion was 32.6%. A thick bowel wall (p < 0.001), mesenteric edema (p < 0.001), and ascites (p = 0.009) were more frequently associated with SMVT, whereas diminished bowel enhancement (p = 0.003) and paralytic ileus (p = 0.039) were more frequent in SMAT. Diminished bowel enhancement (OR = 20; p = 0.007) and paralytic ileus (OR = 16; p = 0.033) were independent findings suggesting life-threatening mesenteric occlusion. Conclusion The ancillary CT findings occur with different frequencies in SMAT and SMVT. However, the independent findings indicating life-threatening mesenteric occlusion are diminished bowel wall enhancement and paralytic ileus. PMID:23323029

  11. TOTAL DPS NYPD TOTAL DPS NYPD

    E-print Network

    Johnson Jr.,, Ray

    NYPD *Non DPS Section TOTAL Murder/Non-Negligent Manslaughter 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 TOTAL DPS NYPD *Non DPS TOTAL Murder/Non-Negligent Manslaughter 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 *Non DPS TOTAL TOTAL DPS NYPD *Non DPS TOTAL Murder/Non-Negligent Manslaughter 0 0 0 0 0 0 0 0 0 0 0 0

  12. Stages of Chronic Lymphocytic Leukemia

    MedlinePLUS

    ... ALL Treatment Childhood AML Treatment Research Chronic Lymphocytic Leukemia Treatment (PDQ®) General Information About Chronic Lymphocytic Leukemia Key Points Chronic lymphocytic leukemia is a type ...

  13. Effect of traumatic occlusion on CGRP and SP immunoreactive nerve fibre morphology in rat molar pulp and periodontium

    Microsoft Academic Search

    I. Kvinnsland; K. J. Heyeraas

    1992-01-01

    Traumatic occlusion provides a trauma that affects the whole tooth and its supporting tissues. To study the effect of this trauma on CGRP and SP immunoreactive nerve morphology in pulp and periodontium, traumatic occlusion was induced in 2-months-old rats. The occlusal surface of the first maxillary molar in 30 rats were unilaterally raised 1 mm with a composite material. At

  14. Minimally Invasive Monitoring of Chronic Central Venous Catheter Patency in Mice Using Digital Subtraction Angiography (DSA)

    PubMed Central

    Figueiredo, Giovanna; Fiebig, Teresa; Kirschner, Stefanie; Nikoubashman, Omid; Kabelitz, Lisa; Othman, Ahmed; Nonn, Andrea; Kramer, Martin; Brockmann, Marc A.

    2015-01-01

    Background Repetitive administration of medication or contrast agents is frequently performed in mice. The introduction of vascular access mini-ports (VAMP) for mice allows long-term vascular catheterization, hereby eliminating the need for repeated vessel puncture. With catheter occlusion being the most commonly reported complication of chronic jugular vein catheterization, we tested whether digital subtraction angiography (DSA) can be utilized to evaluate VAMP patency in mice. Methods Twenty-three mice underwent catheterization of the jugular vein and subcutaneous implantation of a VAMP. The VAMP was flushed every second day with 50 ?L of heparinized saline solution (25 IU/ml). DSA was performed during injection of 100 ?L of an iodine based contrast agent using an industrial X-ray inspection system intraoperatively, as well as 7±2 and 14±2 days post implantation. Results DSA allowed localization of catheter tip position, to rule out dislocation, kinking or occlusion of a microcatheter, and to evaluate parent vessel patency. In addition, we observed different ante- and retrograde collateral flow patterns in case of jugular vein occlusion. More exactly, 30% of animals showed parent vessel occlusion after 7±2 days in our setting. At this time point, nevertheless, all VAMPs verified intravascular contrast administration. After 14±2 days, intravascular contrast injection was verified in 70% of the implanted VAMPs, whereas at this point of time 5 animals had died or were sacrificed and in 2 mice parent vessel occlusion hampered intravascular contrast injection. Notably, no occlusion of the catheter itself was observed. Conclusion From our observations we conclude DSA to be a fast and valuable minimally invasive tool for investigation of catheter and parent vessel patency and for anatomical studies of collateral blood flow in animals as small as mice. PMID:26098622

  15. Scoliosis and dental occlusion: a review of the literature

    PubMed Central

    2011-01-01

    Background Idiopathic scoliosis is a deformity without clear etiology. It is unclear wether there is an association between malocclusion and scoliosis. Several types of occlusion were described in subjects with scoliosis, mostly case-reports. Objectives The aim of this review was to evaluate the type of occluslins more prevalent in subjects with scoliosis Search strategy All randomised and controlled clinical trials identified from the Cochrane Oral Health Group Trials Register, a MEDLINE search using the Mesh term scoliosis, malocclusion, and relevant free text words, and the bibliographies of papers and review articles which reported the outcome of orthodontic treatment in subjects with scoliosis that were published as abstracts or papers between 1970 and 2010. Selection criteria All randomised and controlled clinical trials published as full papers or abstracts which reported quantitative data on the outcomes malocclusion in subjects with scoliosis. Data collection and analysis Data were extracted without blinding to the authors, age of patients or type of occlusion. Main results Using the search strategy eleven observational longitudinal studies were identified. No randomized clinical trials were recorded. Twenty-three cross-sectional studies were recorderd, and the others studies were reviews, editorials, case-reports, or opinions. The clinical trials were often not controlled and were about the cephalometric evaluation after treatment with the modified Milwuakee brace, followed by the orthodontic treatment of the class II relationship with a functional appliance. Clinical trials also included the study of the associations between scoliosis and unilateral crossbite, in children with asymmetry of the upper cervical spine. This association was also investigated in rats, pigs and rabbits in clinical trials. The other associations between scoliosis and occlusion seems to be based only on cross-sectional studies, case-reports, opinions. Authors' conclusions Based on selected studies, this review concludes that there is plausible evidence for an increased prevalence of unilateral Angle Class II malocclusions associated with scoliosis, and an increased risk of lateral crossbite, midline deviation in children affected by scoliosis. Also, documentation of associations between reduced range of lateral movements and scoliosis seem convincing. Data are also mentioned about the association between plagiocephaly and scoliosis. PMID:21801357

  16. [Differential diagnosis and work up of chronic leg ulcers].

    PubMed

    Spoljar, Sanja

    2014-10-01

    Many factors contribute to the pathogenesis of leg ulcers. The main causes are chronic venous insufficiency, peripheral arterial occlusive disease (PAOD) and diabetes. Some leg ulcers are caused by combinations of these well-known etiologic factors. The most common cause of PAOD is arteriosclerosis. In diabetic patients, distal symmetric neuropathy and peripheral vascular disease are probably the most important etiologic factors in the development of leg ulcers. Less frequent causes of chronic leg ulcers are hematologic diseases, autoimmune diseases, genetic defects, infections, primary skin disease, cutaneous malignant diseases, use of some medications and therapeutic procedures, and numerous exogenous factors. Diagnosis of leg ulcer is made upon medical history, clinical picture, palpation of arteries, functional testing and serologic testing. Device-based diagnostic testing should be performed for additional clarification. Also, lesion biopsy should be taken for histopathology, direct immunofluorescence, bacteriology and mycology. The knowledge of differential diagnosis is essential for ensuring treatment success in a patient with leg ulcer. PMID:25326987

  17. Why do young people with chronic kidney disease die early?

    PubMed Central

    Kumar, Shankar; Bogle, Richard; Banerjee, Debasish

    2014-01-01

    Cardiovascular disease poses the greatest risk of premature death seen among patients with chronic kidney disease (CKD). Up to 50% of mortality risk in the dialysis population is attributable to cardiovascular disease and the largest relative excess mortality is observed in younger patients. In early CKD, occlusive thrombotic coronary disease is common, but those who survive to reach end-stage renal failure requiring dialysis are more prone to sudden death attributable mostly to sudden arrhythmic events and heart failure related to left ventricular hypertrophy, coronary vascular calcification and electrolyte disturbances. In this review, we discuss the basis of the interaction of traditional risk factors for cardiovascular disease with various pathological processes such as endothelial dysfunction, oxidative stress, low grade chronic inflammation, neurohormonal changes and vascular calcification and stiffness which account for the structural and functional cardiac changes that predispose to excess morbidity and mortality in young people with CKD. PMID:25374808

  18. Total Flavones of Choerospondias axillaris Attenuate Cardiac Dysfunction and Myocardial Interstitial Fibrosis by Modulating NF-?B Signaling Pathway.

    PubMed

    Sun, Bei; Xia, Qiumei; Gao, Zhiyong

    2015-07-01

    This study aimed to investigate the effect of total flavonoids of Choerospondias axillaris (TFC) on myocardial infarction (MI)-induced cardiac dysfunction, interstitial fibrosis and inflammatory reaction and further to clarify the potential signaling pathway involved. Rats were subjected to MI via coronary artery occlusion. The model establishment was confirmed by the occurrence of ST-segment elevation in electrocardiogram. Then, TFC was administrated at doses of 75, 150 and 300 mg/kg for 28 consecutive days (gavage). Body weight and heart weight were recorded. Hemodynamics, infarct size and myocardial fibrosis were examined. Blood samples were collected to determine tumor necrosis factor-? (TNF-?) and interleukin 6, 10 (IL-6, IL-10) levels. The expressions of matrix metalloproteinases-2, 9 (MMP-2, 9), phosphor-IKB? (p-IKB?) and transforming growth factor-?1 (TGF-?1) were assayed by Western blot. The results indicated that TFC significantly improved cardiac dysfunction, the heart coefficient and myocardial fibrosis in MI rat. TFC also decreased the levels of TNF-? and IL-6, but increased IL-10 content. Moreover, treatment with TFC protected the heart from chronic MI injury by decreasing the expressions of MMP-2, 9, TGF-?1 and p-IKB?. The results suggested that TFC attenuated cardiac dysfunction and myocardial interstitial fibrosis by modulating nuclear factor-kappa B (NF-?B) signaling pathway. PMID:25427792

  19. Chronic Illness and Patient Satisfaction

    PubMed Central

    Carlin, Caroline S; Christianson, Jon B; Keenan, Patricia; Finch, Michael

    2012-01-01

    Objective To examine how the relationship between patient characteristics, patient experience with the health care system, and overall satisfaction with care varies with illness complexity. Data Sources/Study Setting Telephone survey in 14 U.S. geographical areas. Study Design Structural equation modeling was used to examine how relationships among patient characteristics, three constructs representing patient experience with the health care system, and overall satisfaction with care vary across patients by number of chronic illnesses. Data Collection/Extraction Methods Random digital dial telephone survey of adults with one or more chronic illnesses. Principal Findings Patients with more chronic illnesses report higher overall satisfaction. The total effects of better patient–provider interaction and support for patient self-management are associated with higher satisfaction for all levels of chronic illness. The latter effect increases with illness burden. Older, female, or insured patients are more satisfied; highly educated patients are less satisfied. Conclusions Providers seeking to improve their patient satisfaction scores could do so by considering patient characteristics when accepting new patients or deciding who to refer to other providers for treatment. However, our findings suggest constructive actions that providers can take to improve their patient satisfaction scores without selection on patient characteristics. PMID:22515159

  20. [Multidisciplinary study of cerebrovascular disorders. II. Cardiovascular profile of occlusive vascular disorders].

    PubMed

    Corbalán, R; Tapia, J; Braun, S; Arriagada, D; Huete, I; Valdés, F; Serrat, H; Córdova, J L; Chávez, A

    1994-09-01

    Ischemic stroke constitute a mayor cause of morbidity and mortality in the adult population, particularly in the elderly. Heart disease may predispose to ischemic stroke, especially in the presence of transient or permanent precipitating factors such as atrial fibrillation. To elucidate the role of heart disease in predisposing to ischemic stroke we studied the clinical and non invasive cardiac profile (EKG, 2D-Echo, Holter) of 186 consecutive patients, 91 of them embolic (GI) and 96 non embolic (lacunar, atherothrombotic, others) (GII), as determined by brain CT scan and thorough clinical evaluation. Age and male/female ratio were significantly different (71 + 13 vs 65 + 12 years, 40/60 vs 65/35, p < 0.003). Hypertension was equally common in both groups (38 and 40%). Patients in GI had higher prevalence of valvular heart disease (23 vs 1%), atrial fibrillation (67 vs 10%), 2D Echo left atrial enlargement (45 vs 16%) and supraventricular ectopy in Holter (59 vs 32%) p < 0,001. By contrast absence of heart disease (45 vs 19%), ST-T changes in EKG (28 vs 14%), left ventricular hypertrophy in 2D Echo (28 vs 9%) and ventricular ectopy in Holter (54 vs 23%) were more prevalent in GII patients, p < 0.001. Multiple stepwise logistic regression analysis showed age > 70 years (relative risk (RR) 1.67), valvular heart disease (RR 2.25), chronic AF (RR 2.44) and paroxysmal AF (RR 1.89) were significant independent predictors of embolic stroke, whereas the presence of left ventricular hypertrophy in 2D-Echo (RR 0.76) and frequent ventricular premature beats in Holter (RR 0.47) were predictors of occlusive non embolic stroke. Thus, the clinical and non invasive cardiac profile of embolic and non embolic ischemic stroke is significantly different, which is relevant to preventive strategies. PMID:7597332

  1. Depression and Chronic Illness

    MedlinePLUS

    ... related to increased symptoms of depression. Examples of chronic illness include: • heart disease • Parkinson’s disease • multiple sclerosis • stroke • ... not be dismissed as a “normal” reaction to chronic illness, but it is common. Depression is a problem ...

  2. Understanding Chronic Bronchitis

    MedlinePLUS

    ... that 9.9 million Americans reported a physician diagnosis of chronic bronchitis. A person with chronic bronchitis also may develop emphysema. These two conditions together are commonly referred to ...

  3. Chronic thyroiditis (Hashimoto disease)

    MedlinePLUS

    Hashimoto thyroiditis; Chronic lymphocytic thyroiditis; Autoimmune thyroiditis ... Chronic thyroiditis or Hashimoto disease is a common thyroid gland disorder. It can occur at any age, but is most often seen in ...

  4. Coronary artery ectasia--a variant of occlusive coronary arteriosclerosis.

    PubMed Central

    Swanton, R H; Thomas, M L; Coltart, D J; Jenkins, B S; Webb-Peploe, M M; Williams, B T

    1978-01-01

    In a study of 1000 consecutive coronary arteriograms, 12 patients (all men) had coronary artery ectasia. Ectasia was found most frequently in the circumflex or right coronary artery. Only 1 patient had ectasia in the left anterior descending coronary artery. In 11 patients, ectasia of one artery was associated with severe stenosis or occlusion of other vessels, typical of arteriosclerosis. Histology from an ectatic segment in one of this group showed changes of severe arteriosclerosis with extensive intimal fibrosis and destruction of the media. One patient had a mixed collagen vascular disease. Measurement of coronary sinus flow in 2 patients with coronary artery ectasia showed flows in the range of patients with non-ectatic coronary artery disease. At cardiac surgery flows down the graft to ectatic arteries were in the same range as in grafts to non-ectatic vessels. Patients with coronary artery ectasia should be anticoagulated. Images PMID:646906

  5. A stereo matching in complex scene and occlusion handling model

    NASA Astrophysics Data System (ADS)

    Pang, Xing; Zhang, Yi; Han, Jing; Bai, Lian-fa

    2014-11-01

    An algorithm is proposed which the tree structure of dynamic programming with self-adaptive parameters and a disparity iterative refinement to improve stereo matching performance. The algorithm model consists of an initialization model and a disparity iterative refinement. To obtain the initial disparity map with "clear" background and whole details, the tree structure of dynamic programming with self-adaptive parameters is presented. A disparity iterative refinement is proposed to estimate the disparity of unreliable pixels in the doubtful regions. The disparity iterative refinement consists of a doubtful regions growing method and a disparity filling based on color similarity. The results of experiment evaluated with Middlebury data sets show that our algorithm can effectively ameliorate "fatting inflating" by occlusion and obtains a high quality of disparity map.

  6. Critical occlusion via biofilm induced calcite precipitation in porous media

    NASA Astrophysics Data System (ADS)

    Zhang, Tianyu; Klapper, Isaac

    2014-05-01

    A model for biofilm induced calcite precipitation with pressure driven flow is presented at the scale of a single pore within a porous medium. The system, an extension of previous work (Zhang and Klapper 2010 Water Sci. Technol. 61 2957-64, Zhang and Klapper 2011 Int. J. Non-Linear Mech. 46 657-66), is based on a mixture model including biomaterial, mineral, and water with dissolved components. Computational results suggest the possibility of critical occlusion in the sense that there is a distinguished trans-pore pressure head such that for pressure drops below this level, pore clogging occurs relatively quickly while for pressure drops above, clogging occurs after much longer times if at all. Beyond its relevance to engineered biofilm applications, this phenomenon is suggestive of the subtleties of embedding simple biofilm models in larger media.

  7. The sieve element occlusion gene family in dicotyledonous plants

    PubMed Central

    Jekat, Stephan B; Nordzieke, Steffen; Reineke, Anna R; Müller, Boje; Bornberg-Bauer, Erich; Noll, Gundula A

    2011-01-01

    Sieve element occlusion (SEO) genes encoding forisome subunits have been identified in Medicago truncatula and other legumes. Forisomes are structural phloem proteins uniquely found in Fabaceae sieve elements. They undergo a reversible conformational change after wounding, from a condensed to a dispersed state, thereby blocking sieve tube translocation and preventing the loss of photoassimilates. Recently, we identified SEO genes in several non-Fabaceae plants (lacking forisomes) and concluded that they most probably encode conventional non-forisome P-proteins. Molecular and phylogenetic analysis of the SEO gene family has identified domains that are characteristic for SEO proteins. Here, we extended our phylogenetic analysis by including additional SEO genes from several diverse species based on recently published genomic data. Our results strengthen the original assumption that SEO genes seem to be widespread in dicotyledonous angiosperms, and further underline the divergent evolution of SEO genes within the Fabaceae. PMID:21422825

  8. Evaluation of the effects of preconditioning regimens on hepatic veno-occlusive disease in mice after hematopoietic stem cell transplantation.

    PubMed

    Qiao, Jianlin; Fu, Jinyu; Fang, Ting; Huang, Yujin; Mi, Hongling; Yang, Na; Chen, Chao; Xu, Kailin; Zeng, Lingyu

    2015-02-01

    Pre-conditioning regimens before hematopoietic stem cell transplantation (HSCT), such as total body irradiation (TBI) or busulfan/cyclophosphamide (BU/CY), are associated with hepatic veno-occlusive disease (HVOD). However, the mechanism of these regimens on hepatic veno-occlusive disease remains unclear. The aim of this study is to evaluate the effect of TBI or BU/CY on HVOD in mice after HSCT. Mice received TBI or BU/CY followed by HSCT. Analysis of liver pathology and function, and platelet aggregation were performed. Both these regimens caused damage to liver sinusoid endothelial cells, leading to loss of normal structural integrity of liver sinusoid, abnormal liver function, fibrin deposition, inflammatory cells infiltration and platelet aggregation. No differences of liver function in these regimens were observed. Increased hepatic lipid droplets, mitochondrial swelling and higher incidence of HVOD were observed in BU/CY. In conclusion, both TBI and BU/CY caused damage to liver sinusoid endothelial cells and occurrence of HVOD with higher incidence for BU/CY. Meanwhile, inflammation and platelet activation was also observed, suggesting targeting them maybe beneficial in the prophylaxis of HVOD. PMID:25533545

  9. Femoral artery occlusion augments TRPV1-mediated sympathetic responsiveness

    PubMed Central

    Xing, Jihong; Gao, Zhaohui; Lu, Jian; Sinoway, Lawrence I.; Li, Jianhua

    2008-01-01

    Muscle metabolic by-products stimulate thin fiber muscle afferent nerves and evoke reflex increases in blood pressure and sympathetic nerve activity. Previous studies reported that chemically sensitive transient receptor potential vanilloid type 1 (TRPV1) channels present on sensory muscle afferent neurons have an important impact on sympathetically mediated cardiovascular responses. The reflex-mediated reduction in blood flow to skeletal muscle leads to limited exercise capacity in patients with peripheral arterial occlusive disease. Thus, in this study, we tested the hypothesis that the expression of enhanced TRPV1 receptor and its responsiveness in primary afferent neurons innervating muscles initiate exaggerated reflex sympathetic responses after vascular insufficiency to the muscle. Muscle vascular insufficiency was induced by the femoral artery ligation in rats for 24 h. Our data show that 1) the ligation surgery leads to the upregulation of TRPV1 expression in the dorsal root ganglion; 2) the magnitude of the dorsal root ganglion neuron TRPV1 response induced by capsaicin is greater in vascular insufficiency (4.0 ± 0.31 nA, P < 0.05 vs. sham-operated control) than that in sham-operated control (2.9 ± 0.23 nA); and 3) renal sympathetic nerve activity and mean arterial pressure responses to capsaicin (0.5 ?g/kg body wt) are also enhanced by vascular insufficiency (54 ± 11%, 9 ± 2 mmHg in sham-operated controls vs. 98 ± 13%, 33 ± 5 mmHg after vascular insufficiency, P < 0.05). In conclusion, sympathetic nerve responses to the activation of metabolite-sensitive TRPV1 receptors are augmented in rats with the femoral artery occlusion compared with sham-operated control animals, due to alterations in the expression of TRPV1 receptor and its responsiveness in sensory neurons. PMID:18660449

  10. Different Imaging Strategies in Patients With Possible Basilar Artery Occlusion

    PubMed Central

    Beyer, Sebastian E.; Hunink, Myriam G.; Schöberl, Florian; von Baumgarten, Louisa; Petersen, Steffen E.; Dichgans, Martin; Janssen, Hendrik; Ertl-Wagner, Birgit; Reiser, Maximilian F.

    2015-01-01

    Background and Purpose— This study evaluated the cost-effectiveness of different noninvasive imaging strategies in patients with possible basilar artery occlusion. Methods— A Markov decision analytic model was used to evaluate long-term outcomes resulting from strategies using computed tomographic angiography (CTA), magnetic resonance imaging, nonenhanced CT, or duplex ultrasound with intravenous (IV) thrombolysis being administered after positive findings. The analysis was performed from the societal perspective based on US recommendations. Input parameters were derived from the literature. Costs were obtained from United States costing sources and published literature. Outcomes were lifetime costs, quality-adjusted life-years (QALYs), incremental cost-effectiveness ratios, and net monetary benefits, with a willingness-to-pay threshold of $80 000 per QALY. The strategy with the highest net monetary benefit was considered the most cost-effective. Extensive deterministic and probabilistic sensitivity analyses were performed to explore the effect of varying parameter values. Results— In the reference case analysis, CTA dominated all other imaging strategies. CTA yielded 0.02 QALYs more than magnetic resonance imaging and 0.04 QALYs more than duplex ultrasound followed by CTA. At a willingness-to-pay threshold of $80 000 per QALY, CTA yielded the highest net monetary benefits. The probability that CTA is cost-effective was 96% at a willingness-to-pay threshold of $80 000/QALY. Sensitivity analyses showed that duplex ultrasound was cost-effective only for a prior probability of ?0.02 and that these results were only minimally influenced by duplex ultrasound sensitivity and specificity. Nonenhanced CT and magnetic resonance imaging never became the most cost-effective strategy. Conclusions— Our results suggest that CTA in patients with possible basilar artery occlusion is cost-effective. PMID:26022634

  11. What Is Chronic Myeloid Leukemia?

    MedlinePLUS

    ... about chronic myeloid leukemia? What is chronic myeloid leukemia? Chronic myeloid leukemia (CML), also known as chronic ... is the same as for adults. What is leukemia? Leukemia is a cancer that starts in the ...

  12. Sleep and chronic pain

    Microsoft Academic Search

    Jeanetta C Rains; Donald B Penzien

    2003-01-01

    Objective: The ?-EEG sleep anomaly has been associated with chronic benign pain syndromes. Although controversial, the anomaly is believed by some to be an important biologic correlate of certain otherwise poorly explained painful conditions (e.g., fibromyalgia and chronic fatigue syndrome). To shed further light on this phenomenon, this study compared the sleep and psychological characteristics of chronic pain patients who

  13. Chronic pain in adults.

    PubMed

    Ostler, Anneli

    2015-06-10

    Reading the CPD article helped improve my understanding of the importance of identifying chronic pain. Chronic pain may occur on its own or as a feature of other chronic conditions, and it may be nociceptive or neuropathic, or a combination of the two. PMID:26058654

  14. Baculovirus expression vectors that incorporate the foreign protein into viral occlusion bodies.

    PubMed

    Je, Y H; Jin, B R; Park, H W; Roh, J Y; Chang, J H; Seo, S J; Olszewski, J A; O'Reilly, D R; Kang, S K

    2003-01-01

    Current baculovirus expression systems typically produce soluble proteins that accumulate within the infected insect cell or are secreted into the growth medium. A system has now been developed for the incorporation of foreign proteins, along with the matrix protein, polyhedrin, into baculovirus occlusion bodies. Initial studies showed that a recombinant virus expressing a translational fusion between polyhedrin and GFP did not form occlusion bodies. However, a baculovirus coexpressing native polyhedrin and the polyhedrin-GFP fusion protein formed occlusion bodies that fluoresced under UV light, demonstrating that they included the polyhedrin-GFP fusion protein. This was confirmed by immunoblot analysis. Thus, incorporation of a foreign protein into occlusion bodies depends on an interaction between native polyhedrin and the polyhedrin fusion protein. Electron microscopy demonstrated that the occlusion bodies containing GFP also incorporated virions as expected. These ColorPol occlusion bodies were as infectious to insect larvae as occlusion bodies produced by wild-type virus. This new system expands the capabilities for foreign gene expression by baculoviruses, which has implications for biopesticide design, novel vaccine delivery systems, and fusion protein purification applications. PMID:12545544

  15. Complications and surgical conversion after total aortic repair using endovascular repair in patients with Marfan syndrome.

    PubMed

    Numata, Satoshi; Tsutsumi, Yasushi; Ohashi, Hirokazu

    2015-04-01

    We report a case of a Marfan syndrome patient who developed a complicated clinical course after total aortic repair using a hybrid technique. After hybrid total aortic repair, this patient was required to undergo open thoracic and thoracoabdominal aortic repair due to impending rupture of the aorta. Moreover, the abdominal aortic graft was rereplaced due to debranching graft occlusion of the coeliac artery and the left renal artery. PMID:25575789

  16. Measurement of effective elastance of the total respiratory system in ventilated patients by a computed method

    Microsoft Academic Search

    C. Gillard; A. Flémale; J. P. Dierckx; G. Thémelin

    1990-01-01

    We have studied 28 patients mechanically ventilated for acute respiratory failure at different levels of externally applied positive end-expiratory pressure (PEEPe). We describe and compare a computed method of measuring “effective” elastance of the total respiratory system (Ers,eff) with the static values of elastance of the total respiratory system (Ers, st), obtained with the end-inflation occlusion technique. Ers, eff was

  17. Venous occlusion plethysmography based on fiber-optic sensor using the microbending principle

    NASA Astrophysics Data System (ADS)

    Stenow, Erik N.; Rohman, Hakan; Eriksson, Inger; Oberg, P. Ake

    1991-07-01

    Venous occlusion plethysmography is a clinically well-established technique for limb blood flow assessment. In this method, the measurement of volume changes following venous occlusion has been performed with a variety of methods of which the most common is the mercury strain-gauge. Temperature drift and long-term instability are problems associated with this sensor. In addition, environmental protection authorities are prohibiting the use of mercury in sensors beginning in 1993. This paper presents a fiber-optic sensor that can be used as an alternative to the mercury strain-gauge in venous occlusion plethysmography and in other force or displacement sensor applications.

  18. Influence of different professional prophylactic methods on fluorescence measurements for detection of occlusal caries.

    PubMed

    Diniz, M B; Sciasci, P; Rodrigues, J A; Lussi, A; Cordeiro, R C L

    2011-01-01

    This study aimed to evaluate the influence of professional prophylactic methods on the DIAGNOdent 2095, DIAGNOdent 2190 and VistaProof performance in detecting occlusal caries. Assessments were performed in 110 permanent teeth at baseline and after bicarbonate jet or prophylactic paste and rinsing. Performance in terms of sensitivity improved after rinsing of the occlusal surfaces when the prophylactic paste was used. However, the sodium bicarbonate jet did not significantly influence the performance of the fluorescence-based methods. It can be concluded that different professional prophylactic methods can significantly influence the performance of fluorescence-based methods for occlusal caries detection. PMID:21576958

  19. Pregnancy management for a patient with graft occlusion after right iliac artery bypass surgery.

    PubMed

    Nakae, Ruriko; Matsuzaki, Shinya; Egawa-Takata, Tomomi; Mimura, Kazuya; Kanagawa, Takeshi; Kimura, Tadashi

    2015-06-01

    We describe an extremely rare case of a pregnant woman who had a successful delivery despite developing bypass graft occlusion after right external iliac bypass surgery. External and common iliac artery bypass surgery is often performed when arteriosclerosis obliterans or thromboangiitis obliterans result in iliac artery occlusion or when revascularization is required because of iliac artery injury. Because arteriosclerosis obliterans and thromboangiitis obliterans rarely develop in young women or girls, most physicians have little experience with graft occlusion after iliac artery bypass surgery. Here we describe and discuss the published work pertaining to this extremely rare case. PMID:25511914

  20. Successful Recanalization of a Longstanding Right Common Iliac Artery Occlusion with a Radiofrequency Guidewire

    SciTech Connect

    Tapping, C. R.; Uri, I. F.; Dixon, S.; Bratby, M. J.; Anthony, S.; Uberoi, R., E-mail: raman.uberoi@orh.nhs.uk [John Radcliffe Hospital, Department of Radiology (United Kingdom)

    2012-10-15

    We describe a case of successful recanalization of a longstanding right common iliac occlusion with a radiofrequency (RF) guidewire. The patient had been symptomatic with claudication for 3 years, and a preliminary attempt to cross the lesion using conventional techniques proved unsuccessful. Using low and medium intensity RF pulses and a PowerWire, a tract through the occlusion was established, which allowed subsequent stenting with an excellent angiographic result and a good immediate clinical response. We propose this as a useful technique in the peripheral arterial system for occlusive lesions not amenable to traditional recanalization techniques.

  1. Prevalence of Chronic Headache in Croatia

    PubMed Central

    Vukovi?-Cvetkovi?, Vlasta; Lovren?i?-Huzjan, Arijana

    2013-01-01

    Background. Chronic headache describes the presence of headache for >15 days per month on average for >3 months and fulfills the rest of the IHS criteria. The prevalence of chronic headache is within the range of 0.5–7.3% worldwide. The aim of this study was to determine the 1-year prevalence of chronic headache in adult Croatian population. Methods. The data were collected from a cross-sectional survey of an adult population (>18?years of age) sample. Randomly selected patients from the general population in four Croatian cities were asked to fulfill a self-completed questionnaire. The prevalence of chronic headache was calculated in the sample representing 3?383?769 Croatian adults. Results. The total sample included 1542 responders among which 616 were with headache. The 1-year prevalence of chronic headache was 2.4%, and 0.9% of responders declared having headache 30?days per month. According to these results, 81?192 adult inhabitants in Croatia suffer from chronic headache. Conclusions. The prevalence of chronic headache in Croatia is comparable to other countries worldwide. These patients require special attention and should be offered multidisciplinary medical support. PMID:24078925

  2. Occlusive barriers in combination with particulate Bio-Oss® graft: a pilot study on rabbit calvaria

    PubMed Central

    Beltrán, Víctor; Engelke, Wilfried; Dias, Fernando Jose; Leiva, Carolina; Fuentes, Ramón; Borie, Eduardo

    2014-01-01

    The aim of this study was to histologically evaluate the potential for vertical bone augmentation of the Bio-Oss® graft compared to a blood clot in conjunction with an occlusive barrier in the rabbit calvaria defect model. Metallic dome shaped barriers with 4.5 mm width and 3.5 mm height were positioned in six adult rabbit skulls. At the right side, the barrier was filled with Bio-Oss®, and the left side was filled with a blood clot. After a healing period of three months, the animals were sacrificed, and the samples were prepared for histological and histomorphometric analyses. The total mineralized area (TMA) as well as the newly formed bone (NBA) was calculated as the percentage of the bone augmentation inside the metallic barriers, and parametric statistical analysis was used to describe the findings. The samples with blood clots exhibited significantly less TMA formation than the Bio-Oss® group. However, the difference in the amount of NBA was not statistically significant. Furthermore, the Bio-Oss® specimens exhibited remaining graft particles within the sample. In conclusion, the barriers filled with Bio-Oss® exhibited significantly higher TMA than those with only blood clots, and the remaining Bio-Oss® particles were integrated into newly formed bone tissue to fill the spaces and promote a greater volume than the samples from the blood clot groups. PMID:25126169

  3. Occlusive barriers in combination with particulate Bio-Oss® graft: a pilot study on rabbit calvaria.

    PubMed

    Beltrán, Víctor; Engelke, Wilfried; Dias, Fernando Jose; Leiva, Carolina; Fuentes, Ramón; Borie, Eduardo

    2014-01-01

    The aim of this study was to histologically evaluate the potential for vertical bone augmentation of the Bio-Oss® graft compared to a blood clot in conjunction with an occlusive barrier in the rabbit calvaria defect model. Metallic dome shaped barriers with 4.5 mm width and 3.5 mm height were positioned in six adult rabbit skulls. At the right side, the barrier was filled with Bio-Oss®, and the left side was filled with a blood clot. After a healing period of three months, the animals were sacrificed, and the samples were prepared for histological and histomorphometric analyses. The total mineralized area (TMA) as well as the newly formed bone (NBA) was calculated as the percentage of the bone augmentation inside the metallic barriers, and parametric statistical analysis was used to describe the findings. The samples with blood clots exhibited significantly less TMA formation than the Bio-Oss® group. However, the difference in the amount of NBA was not statistically significant. Furthermore, the Bio-Oss® specimens exhibited remaining graft particles within the sample. In conclusion, the barriers filled with Bio-Oss® exhibited significantly higher TMA than those with only blood clots, and the remaining Bio-Oss® particles were integrated into newly formed bone tissue to fill the spaces and promote a greater volume than the samples from the blood clot groups. PMID:25126169

  4. Flavonoid intake and risk of chronic diseases1,2

    Microsoft Academic Search

    Paul Knekt; Jorma Kumpulainen; Ritva Järvinen; Harri Rissanen; Markku Heliövaara; Antti Reunanen; Timo Hakulinen; Arpo Aromaa

    Background: Flavonoids are effective antioxidants and may pro- tect against several chronic diseases. Objective: The association between flavonoid intake and risk of several chronic diseases was studied. Design: The total dietary intakes of 10 054 men and women dur- ing the year preceding the baseline examination were determined with a dietary history method. Flavonoid intakes were estimated, mainly on the

  5. Assessment of chronic constipation: colon transit time versus defecography

    Microsoft Academic Search

    R. W Prokesch; M. J Breitenseher; J Kettenbach; F Herbst; A Maier; G Lechner; P Mahieu

    1999-01-01

    Objective: The aim of this study was to determine the value of radiological colon transit time (CTT) measurements in relation to defecography (DFG) in chronically constipated patients. Materials and methods: In 30 patients with chronic constipation, total and segmental CTT was determined using radiopaque markers. In all of these patients defecography (DFG) was obtained. The patients were divided into three

  6. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure

    Microsoft Academic Search

    Anne B Guttormsen; Per M Ueland; Einar Svarstad; Helga Refsum

    1997-01-01

    Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure. We investigated the elimination of total homocysteine (tHcy) from plasma after peroral homocysteine (Hcy) loading in eight patients with chronic renal failure. Data on bioavailability and distribution volume were obtained from two patients and two healthy controls by performing both intravenous and peroral Hcy loading. Response to high-dose folic acid

  7. Functional Electrical Therapy (FET): Clinical Trial in Chronic Hemiplegic Subjects

    Microsoft Academic Search

    Mirjana B. Popovic; Dejan B. Popovic; Laszlo Schwirtlich; Thomas Sinkjaer

    2004-01-01

    ? A BSTRACT Results from a clinical evaluation of Functional Electri- cal Therapy (FET) in chronic hemiplegic subjects are presented. FET is an intensive exercise that integrates voluntary maximized manipulation and augmented grasping by electrical stimulation of forearm and hand muscles. A total of 16 chronic hemiplegic subjects participated in a six-month long study. The subjects were divided into lower

  8. Total body irradiation plus cyclophosphamide versus busulphan with cyclophosphamide as conditioning regimen for patients with leukemia undergoing allogeneic stem cell transplantation: a meta-analysis.

    PubMed

    Shi-Xia, Xu; Xian-Hua, Tang; Hai-Qin, Xu; Bo, Feng; Xiang-Feng, Tang

    2010-01-01

    The aim of the study was to compare the therapeutic efficacy of total body irradiation (TBI)/cyclophosphamide (CY) versus BU/CY as conditioning regimen for leukemia. We electronically searched the Cochrane Central Register of Controlled Trials, Medline, Embase, CIBMTR and critically appraised all relevant articles (1990.01-2009.04). Comparative studies were evaluated on clinical therapeutic effects of TBI/CY and busulphan BU/CY regimens with assessement of engraftment, relapse, complications, and disease-free survival (DFS). Eighteen trials totaling 3172 patients have been assessed. Pooled comparisons of studies indicated that for patients with acute leukemia (ALL and AML), the TBI/CY regimen lead to lower rates of leukemia relapse, lower transplant-related mortality (TRM), and higher DFS, while for chronic myeloid leukemia (CML), the TBI/CY regimen had a higher rate of leukemia relapse, lower TRM, and similar DFS. The TBI/CY regimen was associated with similar occurrence of engraftment, acute and chronic graft-versus-host disease (GVHD), but with higher rates of cataract [odds ratio (OR) 12.69, p = 0.01], interstitial pneumonitis, later growth or development problems [OR 5.04, p = 0.008]. BU/CY regimen was associated with higher rates of complications like liver veno-occlusive disease [OR 0.43, p < 0.00001], hemorrhagic cystitis, and TRM. Our meta-analysis confirmed that different regimens and type of leukemia may affect the complications and outcome. An analysis of the effects of other regimens need to be carried out by large sample and well-designed clinical trials. PMID:20055658

  9. CO-OCCLUSION AND PERSISTENCE OF A BACULOVIRUS MUTANT LACKING THE POLYHEDRIN GENE

    EPA Science Inventory

    A co-occlusion process was evaluated as a commercially and ecologically acceptable strategy for the development of genetically improved baculovirus insecticides. oinfection of Spodoptera frugiperda (IPLB-SF-21) tissue culture cells with Aucographa californica nuclear polyhedrosis...

  10. Early characterization of occlusal overloaded cervical dental hard tissues by en face optical coherence tomography

    NASA Astrophysics Data System (ADS)

    Marcauteanu, Corina; Negrutiu, Meda; Sinescu, Cosmin; Stoica, Eniko Tunde; Ionita, Ciprian; Florin, Topala; Vasile, Liliana; Bradu, Adrian; Dobre, George; Podoleanu, Adrian G.

    2011-06-01

    Early diagnosis of occlusal overload is an important issue in dental medicine. The high occlusal forces can cause irreversible damage to the dental hard tissues. Our study proposes the early microstructural characterization of occlusal overloaded bicuspids, with abnormal crown morphology, by en face optical coherence tomography (eFOCT). The dental samples were investigated using an eFOCT system operating at 1300 nm in B-scan and C-scan mode. The eFOCT images obtained from these teeth visualized cracks, which didn't reach the tooth surface. The ?CT and histological images confirmed the microstructural defects identified on eFOCT images. In conclusion, eFOCT is a promising imaging method for the early diagnosis of occlusal overload on bicuspids with normal crown morphology and for the prophylaxis of dental wear.

  11. Videoendoscopically assisted combined retroperitoneal and pelvic extraperitoneal approach for aortoiliac occlusive disease

    Microsoft Academic Search

    P. K. Chowbey; R. Panse; A. Sharma; R. Khullar; V. Soni; M. Baijal

    2005-01-01

    Background: Laparoendoscopic surgery has emerged as a new methodfor the management of iliac andaortoiliac occlusive disease. This article describes a combined retroperitoneal andpelvic extraperitoneal approach to aorta andiliac arteries.

  12. Relationship between occlusal plane and ala-tragus line in dentate individuals: A Clinical pilot study.

    PubMed

    Nayar, Sanjna; Bhuminathan, S; Bhat, Wasim Manzoor; Mahadevan, R

    2015-04-01

    Many methods have been used to establish the occlusal plane in complete denture prosthodontics. However, no single method seems to be fully accepted. Anteriorly, esthetic considerations help define the occlusal plane, and posteriorly the tongue, retromolar pad, and Stenson's duct are considered. Some dentists bisect the space between the residual ridges. The technique of using the ala-tragus line (Camper's line) to establish the occlusal plane is well documented. However, definitions of the ala-tragus line cause confusion, because the exact points of reference do not agree. For example, the glossary of prosthodontic terms states that the ala-tragus line runs from the inferior border of the ala of the nose to the superior border of the tragus of the ear while Spratley' describes it as running from the center of the ala to the center of the tragus. This article concerns us the exact relationship between the occlusal plane and ala-tragus line in dentate individuals. PMID:26015765

  13. Relationship between occlusal plane and ala-tragus line in dentate individuals: A Clinical pilot study

    PubMed Central

    Nayar, Sanjna; Bhuminathan, S.; Bhat, Wasim Manzoor; Mahadevan, R.

    2015-01-01

    Many methods have been used to establish the occlusal plane in complete denture prosthodontics. However, no single method seems to be fully accepted. Anteriorly, esthetic considerations help define the occlusal plane, and posteriorly the tongue, retromolar pad, and Stenson's duct are considered. Some dentists bisect the space between the residual ridges. The technique of using the ala-tragus line (Camper's line) to establish the occlusal plane is well documented. However, definitions of the ala-tragus line cause confusion, because the exact points of reference do not agree. For example, the glossary of prosthodontic terms states that the ala-tragus line runs from the inferior border of the ala of the nose to the superior border of the tragus of the ear while Spratley’ describes it as running from the center of the ala to the center of the tragus. This article concerns us the exact relationship between the occlusal plane and ala-tragus line in dentate individuals. PMID:26015765

  14. Deciduous teeth occlusal caries detection with 655-nm diode laser confirmed by surface scanning electron microscopy

    NASA Astrophysics Data System (ADS)

    Duarte, Danilo; Fonseca, Yara P. C.; Zanin, Fatima A. A.; Brugnera, Aldo, Jr.

    2000-03-01

    The morphological complexity of the occlusal surface of deciduous molar teeth is considered as a factor to increase vulnerability to caries lesion. Occlusal surface of these teeth shows sulcus, pits and fissures which allow retention of both micro-organisms and food debris which make them more susceptible to caries. In the last decades there was a significant reduction on caries of smooth surface but not on the occlusal surface where dentinal caries develops under fissures which are apparently caries-free under eye observation. This is known as a hidden caries. The occlusal surface of sound extracted deciduous molar teeth were examined using a 655 nm diode laser (DIAGNOdent - KaVo) in order to detect hidden caries. When there was indication of a hidden caries, the area was examined using SEM and confirm or not the diagnosis. The authors concludes that the diagnosis of caries using 655 diode laser is reliable and precise method.

  15. Making GUIs Narcissistic: Toolkit for Managing Space and Occlusion by Visual Introspection

    E-print Network

    Golbeck, Jennifer

    Making GUIs Narcissistic: Toolkit for Managing Space and Occlusion by Visual Introspection Tom Yeh or Maryland, College Park {tomyeh, kristw, ben, lsd}@cs.umd.edu ABSTRACT Effective use of screen space

  16. Three-dimensional mapping of oxygen tension in cortical arterioles before and after occlusion

    PubMed Central

    Kazmi, S. M. Shams; Salvaggio, Anthony J.; Estrada, Arnold D.; Hemati, Michael A.; Shaydyuk, Nazariy K.; Roussakis, Emannuel; Jones, Theresa A.; Vinogradov, Sergei A.; Dunn, Andrew K.

    2013-01-01

    Occlusions in single cortical microvessels lead to a reduction in oxygen supply, but this decrement has not been able to be quantified in three dimensions at the level of individual vessels using a single instrument. We demonstrate a combined optical system using two-photon phosphorescence lifetime and fluorescence microscopy (2PLM) to characterize the partial pressure of oxygen (pO2) in single descending cortical arterioles in the mouse brain before and after generating a targeted photothrombotic occlusion. Integrated real-time Laser Speckle Contrast Imaging (LSCI) provides wide-field perfusion maps that are used to monitor and guide the occlusion process while 2PLM maps changes in intravascular oxygen tension. We present the technique’s utility in highlighting the effects of vascular networking on the residual intravascular oxygen tensions measured after occlusion in three dimensions. PMID:23847732

  17. Central venous line complications with chronic ambulatory infusion of prostacyclin analogues in pediatric patients with pulmonary arterial hypertension

    PubMed Central

    Mullen, Mary P.

    2015-01-01

    Abstract Chronic infusion of prostacyclin (PGI2) via a Broviac central venous line (CVL) is attended by risk of CVL-related complications, but we know of only one report regarding CVL-associated bloodstream infection (BSI) with PGI2 in children and none regarding other complications. We conducted a retrospective cohort study involving pediatric patients with pulmonary hypertension treated with chronic intravenous infusion of PGI2 at Boston Children’s Hospital and determined the rate (per 1,000 line-days) of various CVL-related complications. We also determined how often complications necessitated line replacement and hospitalization, time to replacement of CVLs, and interpatient variability in the incidence of complications. From 1999 until 2014, 26 patients meeting follow-up criteria had PGI2 infusion, representing 43,855 line-days; mean follow-up was 56 months (range, 1.4–161 months). The CVL complication rates (per 1,000 line-days) were as follows: CVL-BSI, 0.25; superficial line infection, 0.48; impaired integrity, 0.59; occlusion, 0.09; and malposition, 0.32. The total complication rate was 1.73 cases per 1,000 line-days. All CVL-BSI and malposition cases were treated with CVL removal and replacement. Of CVLs with impaired integrity, 23 could be repaired and 3 required replacement. Six of 21 superficial CVL infections required replacement of the CVL. Three of 4 occluded CVLs were replaced. CVL complications occasioned 65 hospitalizations. There was marked interpatient variability in the rate of complications, much but not all of which appeared to be related to duration of CVL placement. We conclude that non-BSI complications are very significant and that efforts to teach and emphasize other aspects of line care are therefore very important.

  18. Expression of polysialylated neural cell adhesion molecule in rat brain after transient middle cerebral artery occlusion

    Microsoft Academic Search

    Takeshi Hayashi; Tatsunori Seki; Keiko Sato; Masanori Iwai; Wen Ri Zhang; Yasuhiro Manabe; Koji Abe

    2001-01-01

    The highly polysialylated form of neural cell adhesion molecule (PSA-NCAM) is important for neurite outgrowth. With this molecule as a marker of plastic change in neurons, we investigated its temporal expression in rat brain after transient middle cerebral artery (MCA) occlusion. In sham-control brain, only subependymal neurons showed a positive immunoreactivity for PSA-NCAM. After 90 min of transient MCA occlusion,

  19. Radiofrequency Guide Wire Recanalization of Venous Occlusions in Patients with Malignant Superior Vena Cava Syndrome

    SciTech Connect

    Davis, Robert M.; David, Elizabeth; Pugash, Robyn A.; Annamalai, Ganesan, E-mail: ganesan.annamalai@sunnybrook.ca [Sunnybrook Health Sciences Centre, Department of Interventional Radiology (Canada)

    2012-06-15

    Fibrotic central venous occlusions in patients with thoracic malignancy and prior radiotherapy can be impassable with standard catheters and wires, including the trailing or stiff end of a hydrophilic wire. We report two patients with superior vena cava syndrome in whom we successfully utilized a radiofrequency guide wire (PowerWire, Baylis Medical, Montreal, Quebec, Canada) to perforate through the occlusion and recanalize the occluded segment to alleviate symptoms.

  20. A numerical simulation method for dental occlusion with forces applied to the tooth in mandible

    Microsoft Academic Search

    Tokumasa Akashi; Yoshihiro Takao; Masahiko Terazima; Wen-Xue Wang; Akihiko Nakashima

    \\u000a This chapter presents the way to simulate dental occlusion by using a three-dimensional finite element method. A series of\\u000a conventional linear elastic analysis is proposed. Thus, two issues are discussed: how to define occlusal loads and how to\\u000a realize the delicately distributed loads at the top surface of tooth by a small number of elements there.

  1. Stenting of a symptomatic long-segment extracranial vertebral artery occlusion

    Microsoft Academic Search

    Rishi Gupta; Thinesh Sivapatham; Shaye I Moskowitz; Sunita Srivastava

    2010-01-01

    We present a 56-year-old man who presented with bilateral vertebral artery occlusions and recurrent transient ischemic attacks and strokes despite maximal medical therapy. A long-segment extracranial right vertebral occlusion was noted and successfully reconstructed with four drug-eluting stents. The patient has been symptom free for 3 months and does not exhibit restenosis on follow-up angiography. Stenting and angioplasty of a

  2. External iliac artery occlusion in a paediatric patient following handlebar trauma

    PubMed Central

    Singla, Animesh A.; McPherson, Danielle; Singla, Apresh A; Cross, Jane; Leslie, Anthony

    2015-01-01

    Arterial occlusion following blunt trauma is an uncommon occurrence. We report an unusual case of delayed external iliac artery occlusion in a young male following blunt abdominal injury. He was successfully treated with thromboendarterectomy and saphenous vein patch repair. There have only been a handful of documented cases occurring in the paediatric population. All patients presenting with groin injury from this mechanism should be carefully investigated and monitored for risk of vascular injury. PMID:25733671

  3. Impact of measuring multiple or single occlusal lesions on estimates of diagnostic accuracy using fluorescence methods

    Microsoft Academic Search

    Anahita Jablonski-Momeni; Simon M. Rosen; Helge M. Schipper; Richard Stoll; Matthias J. Roggendorf; Monika Heinzel-Gutenbrunner; Vitus Stachniss; Klaus Pieper

    Carious lesions can occur at different sites on the occlusal surfaces of teeth and may differ in appearance and severity.\\u000a This study aimed to evaluate how scoring several lesions on occlusal surfaces, as opposed to only one representative lesion,\\u000a affects estimates of reproducibility and accuracy of fluorescence-based devices. Thirty-six permanent teeth with 2-3 investigation\\u000a sites (n?=?82) were examined by two

  4. In vivo comparison of laser fluorescence measurements with conventional methods for occlusal caries detection

    Microsoft Academic Search

    Meryem Toraman Alkurt; Ilkay Peker; Hacer Deniz Arisu; Oya Bala; Bülent Altunkaynak

    2008-01-01

    The purpose of this study was to evaluate the efficiency of the laser fluorescence (LF) (DIAGNOdent) measurements comparing\\u000a with visual examination and conventional bitewing radiography for occlusal caries detection. The study comprised 44 occlusal\\u000a surfaces. Three examiners independently evaluated the teeth by visual examination, LF measurements, and bitewing radiographs.\\u000a After the evaluations, the teeth were opened, and the clinical lesion

  5. Implications of Natural Occlusion of Ventilated Racks on Ammonia and Sanitation Practices

    PubMed Central

    Creamer, Michelle A; Petty, Joann; Martin, Tara; Bergdall, Valerie; Hickman-Davis, Judy M

    2014-01-01

    Examination of ventilated rat racks prior to semiannual sanitation revealed silicone nozzles and ventilation ports that were partially or completely occluded with granular debris. We subsequently sought to document performance standards for rack sanitation and investigate the effect of ventilation port occlusion on rack function and animal husbandry practices. We hypothesized that individually ventilated cages with occluded airflow would require more frequent cage changes, comparable to those for static cages (that is, every 3 to 4 d). Sprague–Dawley rats were housed under one of 4 conditions: no airflow occlusion, occluded air-supply inlet, occluded air-exhaust outlet, and occlusion of both inlet and outlet. Cages were changed when daily ammonia concentration exceeded 20 ppm or after 14 d had elapsed. Most cages with unoccluded or partial airflow occlusion remained below the 20 ppm limit until day 12 or 13. Cages with occlusion of both inlet and outlet exceeded 20 ppm ammonia by as early as day 5. Airflow was significantly lower in cages with occlusion of both inlet and outlet airflow. Weekly inspection revealed that occlusion of ventilation ports was detectable by 3 mo after semiannual sanitation. This study demonstrates that silicone nozzles should be removed prior to rack sanitation to improve the effectiveness of cleaning ventilation ports and nozzles. While the rack is in use, silicone nozzles and ventilation ports should be inspected regularly to identify occlusion that is likely to diminish environmental quality in the cage. Intracage ammonia levels are significantly higher when both inlet and outlet airflow are occluded. PMID:24602544

  6. Acute coronary artery occlusion likely due to thrombus occurring during coronary angiography: report of a case.

    PubMed

    Bonafede, N; Schwartz, L

    1998-04-01

    Twenty-five years ago, fatalities due to acute thrombotic coronary occlusion occurring during coronary angiography were reported not infrequently, but are thought to have been eliminated by changes in technique and equipment. We present a case with documentation of a normal coronary arterial tree just before the time of an abrupt occlusion, which had the angiographic features of clot. The likely source of the thrombus was the arterial sheath. Measures for prevention of this complication are discussed. PMID:9554781

  7. Vaso-occlusion in sickle cell disease: pathophysiology and novel targeted therapies

    PubMed Central

    Manwani, Deepa

    2013-01-01

    Recurrent and unpredictable episodes of vaso-occlusion are the hallmark of sickle cell disease. Symptomatic management and prevention of these events using the fetal hemoglobin–reactivating agent hydroxyurea are currently the mainstay of treatment. Discoveries over the past 2 decades have highlighted the important contributions of various cellular and soluble participants in the vaso-occlusive cascade. The role of these elements and the opportunities for therapeutic intervention are summarized in this review. PMID:24052549

  8. Intravitreal triamcinolone acetonide as treatment of macular edema in central retinal vein occlusion

    Microsoft Academic Search

    Jost B. Jonas; Ingrid Kreissig; Robert F. Degenring

    2002-01-01

    Purpose. To report the clinical outcome of a patient receiving an intravitreal injection of triamcinolone acetonide as treatment of bilateral, long-standing, cystoid macular edema due to central retinal vein occlusion. Methods. A 70-years-old patient suffering from bilateral central retinal vein occlusion for 2 years and 1.5 years, respectively, received transconjunctivally an intravitreal injection of 25 mg of crystalline triamcinolone acetonide

  9. Characteristics, detection methods and treatment of questionable occlusal carious lesions: findings from the national dental practice-based research network.

    PubMed

    Makhija, S K; Gilbert, G H; Funkhouser, E; Bader, J D; Gordan, V V; Rindal, D B; Pihlstrom, D J; Qvist, V

    2014-01-01

    Questionable occlusal carious lesions (QOC) can be defined as an occlusal tooth surface with no cavitation and no radiographic radiolucencies, but caries is suspected due to roughness, surface opacities or staining. An earlier analysis of data from this study indicates 1/3 of patients have a QOC. The objective of this report has been to quantify the characteristics of these common lesions, the diagnostic aids used and the treatment of QOC. A total of 82 dentist and hygienist practitioner-investigators from the USA and Denmark in the National Dental Practice-Based Research Network participated. When consenting patients presented with a QOC, information was recorded about the patient, tooth, lesion and treatments. A total of 2,603 QOC from 1,732 patients were analyzed. The lesions were usually associated with a fissure, on molars, and varied from yellow to black in color. Half presented with a chalky luster and had a rough surface when examined with an explorer. There was an association between color and luster: 10% were chalky-light, 47% were shiny-dark and 42% were mixtures. A higher proportion of chalky than of shiny lesions were light (22 vs. 9%; p < 0.001). Lesions light in color were less common in adults than in pediatric patients (9 vs. 32%; p < 0.001). Lesions that were chalky and light were more common among pediatric than among adult patients (22 vs. 6%; p < 0.001). This is the first study to investigate characteristics of QOC in routine clinical practice. Clinicians commonly face this diagnostic uncertainty. Determining the characteristics of these lesions is relevant when making diagnostic and treatment decisions. PMID:24480989

  10. Chronic tinnitus as phantom auditory pain

    Microsoft Academic Search

    Robert L. Folmer; Susan E. Griest; William Hal Martin

    2001-01-01

    Objectives: To investigate similarities between patients who experience chronic tinnitus or pain and to formulate treatment strategies that are likely to be effective for patients who experience phantom auditory pain. Study design: A total of 160 patients rated the severity and loudness of their tinnitus and completed the State-Trait Anxiety Inventory (STAI) and an abbreviated version of the Beck Depression

  11. Cardiac surgery in patients under chronic hemodialysis

    Microsoft Academic Search

    P. Garrido; J. F. Bobadilla; J. Albertos; J. González Santos; E. Bastida; J. L. Vallejo; R. Arcas

    1995-01-01

    A total of 15 chronic renal failure patients on hemodialysis therapy underwent some kind of cardiovascular surgery between August 1984 and March 1993. Ten had a valve abnormality, and the remaining five had coronary artery disease. All of them were hemodialyzed the day before surgery and 24–48 h after the operation. Eleven recovered well after surgery, four died of septic

  12. Hydrocarbon exposure and chronic renal disease

    Microsoft Academic Search

    Nabih R. Asal; Harold L. Cleveland; Christian Kaufman; Wato Nsa; Deborah I. Nelson; Robert Y. Nelson; Elisa T. Lee; Beverly Kingsley

    1996-01-01

    The study objective was to investigate further the potential role of long-term exposure to hydrocarbons (HCs) in the development of idiopathic chronic glomerulopathy (ICG) using a more refined measurement of HC exposure. A total of 321 pairs of cases and controls, matched by age, gender, and geographical area, were assembled. A detailed questionnaire was blindly administered to cases and controls

  13. Homeostasis of the epidermal barrier layer: a theory of how occlusion reduces hypertrophic scarring.

    PubMed

    O'Shaughnessy, Kristina D; De La Garza, Mauricio; Roy, Nakshatra K; Mustoe, Thomas A

    2009-01-01

    The mechanism of hypertrophic scar reduction using silicone gel sheeting remains elusive. We hypothesize that the decrease in scar formation is due to occlusion and homeostasis of the barrier layer. Using an established model of hypertrophic scarring, rabbits were divided into four groups and scars were tape-stripped or occluded with Kelocote, Cavilon, or Indermil, with each rabbit serving as its own internal control. All wounds were harvested on day 28 and examined histologically to measure the scar elevation index (SEI), epithelial thickness, and cellularity. Immunohistochemistry fluorescence was used to quantify inflammation in the dermis. Transepidermal water loss (TEWL) was measured for each occlusive agent and tape stripping. Ultrastructural analysis was performed by electron microscopy. Kelocote, Cavilon, and Indermil all significantly decreased SEI when compared with controls. Each of the occlusive treatments was shown to decrease TEWL while tape stripping increased TEWL. Tape stripping significantly increased the SEI, epithelial thickness, and cellularity. Immunostaining for macrophages showed increased density of inflammatory cells in the tape-stripped scars. Under electron microscopy, the tape-stripped wounds displayed extensive inflammation and keratinocyte damage. Both unwounded skin and occlusion-treated scars did not display these characteristics. In conclusion, hypertrophic scarring was reduced regardless of occlusive method used. Furthermore, repeated disruption of the permeability barrier by tape stripping led to an increase in scarring. Ultrastructural analysis suggests that occluded wounds may be in an advanced state of wound repair. Occlusion may mediate its effects through establishing homeostasis of the epidermal barrier layer. PMID:19769722

  14. An Automatic Occlusion Device for Remote Control of Tumor Tissue Ischemia

    PubMed Central

    El-Dahdah, Hamid; Wang, Bei; He, Guanglong; Xu, Ronald X.

    2015-01-01

    We developed an automatic occlusion device for remote control of tumor tissue ischemia. The device consists of a flexible cannula encasing a shape memory alloy wire with its distal end connected to surgical suture. Regional tissue occlusion was tested on both the benchtop and the animal models. In the benchtop test, the occlusion device introduced quantitative and reproducible changes of blood flow in a tissue simulating phantom embedding a vessel simulator. In the animal test, the device generated a cyclic pattern of reversible ischemia in the right hinder leg tissue of a black male C57BL/6 mouse. We also developed a multimodal detector that integrates near infrared spectroscopy and electron paramagnetic resonance spectroscopy for continuous monitoring of tumor tissue oxygenation, blood content, and oxygen tension changes. The multimodal detector was tested on a cancer xenograft nude mouse undergoing reversible tumor ischemia. The automatic occlusion device and the multi-modal detector can be potentially integrated for closed-loop feedback control of tumor tissue ischemia. Such an integrated occlusion device may be used in multiple clinical applications such as regional hypoperfusion control in tumor resection surgeries and thermal ablation processes. In addition, the proposed occlusion device can also be used as a research tool to understand tumor oxygen transport and hemodynamic characteristics. PMID:20082532

  15. Value of CT angiography in anterior circulation large vessel occlusive stroke: Imaging findings, pearls, and pitfalls.

    PubMed

    Power, Sarah; McEvoy, Sinead H; Cunningham, Jane; Ti, Joanna P; Looby, Seamus; O'Hare, Alan; Williams, David; Brennan, Paul; Thornton, John

    2015-07-01

    Hyperacute stroke imaging is playing an increasingly important role in determining management decisions in acute stroke patients, particularly patients with large vessel occlusive stroke who may benefit from endovascular intervention. CT angiography (CTA) is an important tool in the work-up of the acute stroke patient. It reliably detects large occlusive thrombi in proximal cerebral arteries and is a quick and highly accurate method in identifying candidates for endovascular stroke treatment. In this article we review the imaging findings on CTA in acute large vessel occlusive stroke using a pictorial case based approach. We retrospectively reviewed CTA studies in 48 patients presenting with acute anterior circulation large vessel occlusive stroke who were brought for intra-arterial acute stroke intervention. We discuss and illustrate patterns of proximal intracranial arterial occlusion, collateralization to the occluded territory, as well as reviewing some important pearls, pitfalls and teaching points in CTA assessment of the acute stroke patient. Performed from the level of the aortic arch CTA also gives valuable information regarding the state of other vessels in the acute stroke patient, identifying additional significant vascular stenoses or occlusions, and as we illustrate, can demonstrate other clinically significant findings which may impact on patient management and outcome. PMID:25956493

  16. Chronic Idiopathic Diarrhea

    Microsoft Academic Search

    Lawrence R. Schiller

    \\u000a Chronic diarrhea is defined as passage of loose stools for more than 4 weeks. In most instances the cause of chronic diarrhea\\u000a can be discovered and treated effectively. A few less common causes also play a role: laxative abuse, small bowel bacterial\\u000a overgrowth, and even bile acid malabsorption. Rarer syndromes account for a much smaller percentage of chronic diarrheas but

  17. Total endoscopic off-pump coronary artery bypass grafting.

    PubMed

    Falk, V; Diegeler, A; Walther, T; Jacobs, S; Raumans, J; Mohr, F W

    2000-01-01

    Two cases of totally endoscopic off-pump coronary artery bypass grafting (TECAB) of the left internal thoracic artery to the left anterior descending artery using the da Vincitrade mark telemanipulation system (Intuitive Surgical, Mountain View, CA) are described. A new articulating endoscopic stabilizer with cleats was developed to enable endoscopic anchoring of silastic vessel loops for vascular occlusion. Newly created attachments for irrigation and suction, along with active robotic enhanced assistance by a second surgical console, permitted our group to perform for the first time a truly endoscopic bypass grafting without any thoracotomy. PMID:11064543

  18. Total dependence of the cerebral circulation on the right vertebral artery in Takayasu's disease—A case report

    Microsoft Academic Search

    Dirk S. Elewaut; Daniel A. Duprez; Marc L. De Buyzere; Marc F. Kunnen; Denis L. Clement

    1994-01-01

    A twenty-four-year-old woman with Takayasu's disease was admitted in June 1992 to the hospital because of amaurosis fugax. There were neither a history of stroke nor other neurologic signs. For a long time the patient had suffered from extreme fatigue and claudication of the upper limbs. In 1988 arteriography revealed total occlusion of both subclavian arteries and a severe filiform

  19. Increased incidence of monoclonal B-cell infiltrate in chronic myeloproliferative disorders

    Microsoft Academic Search

    László Pajor; Ágnes Lacza; László Kereskai; Pál Jáksó; Miklós Egyed; János L Iványi; Gáspár Radványi; Péter Dombi; Katalin Pál; Hajna Losonczy

    2004-01-01

    A total of 106 trephine biopsy specimens with clinical, laboratory and pathology findings corresponding to chronic myeloproliferative disorders (CMPD) were analyzed to reveal the nature of the lymphoid infiltrate in the bone marrow. Histological investigation in 31 chronic myeloid leukemia (CML), 29 CMPDs not otherwise specified (CMPD-NOS), 28 essential thrombocytosis (ET), 15 polycythemia vera (PV) and three chronic eosinophilic leukemia\\/hypereosinophilic

  20. Parental Involvement of Mothers with Chronic Illness and Children's Academic Achievement

    ERIC Educational Resources Information Center

    Chen, Yung-Chi; Fish, Marian C.

    2013-01-01

    This study examined how maternal chronic illnesses may affect children's academic achievement through parental involvement. A total of 189 mothers diagnosed with chronic illnesses, such as multiple sclerosis, diabetes, cancer, HIV/AIDS, chronic pain, asthma, myelodysplasic syndrome, and fibromyalgia, and with a child in middle school or high…