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1

FACTORES SOCIO-ESTRUCTURALES Y EL ESTIGMA HACIA EL VIH/SIDA: EXPERIENCIAS DE PUERTORRIQUEŃOS/AS CON VIH/SIDA AL ACCEDER SERVICIOS DE SALUD  

PubMed Central

RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha seńalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599

RIVERA-DIAZ, MARINILDA; VARAS-DIAZ, NELSON; REYES-ESTRADA, MARCOS; SURO, BEATRIZ; CORIANO, DORALIS

2013-01-01

2

El desempleo espanol: factores estructurales  

Microsoft Academic Search

Unemployment is one of the most important problems of the Spanish and European economies. A possible analysis, vastly extended in recent literature, focuses on mismatch problems between labour demand and supply. In this sense, the empirical relationship between the vacancy rate and the unemployment rate, the so-called Beveridge curve or UV curve, offers an instrument to characterise the unemployment of

Jorge Lopez Tamayo; Jordi Surinach Caralt

1999-01-01

3

Estudios estructurales sobre entidades tiosemicarbazonacobre(II) y su interacción con polioxometalatos y biomoléculas: síntesis, estabilidad y propiedades magnéticas.  

E-print Network

??Estudios estructurales sobre entidades tiosemicarbazonacobre(II) y su interacción con polioxometalatos y biomoléculas. Síntesis, estabilidad y propiedades magnéticas? El presente Trabajo ahonda en la síntesis y… (more)

Gil García, Rubén

2012-01-01

4

Factoring  

NSDL National Science Digital Library

Test your factoring skills Factors and Multiples Jeopardy How much do you know about factoring and multiples? Play Jeopardy and find out! Prime Factoring Turkey Shoot Blast these turkeys using your factoring skills. Help the Professor Super save the planet by "cooking" the Giant Frozen Turkeys of Destruction. Math Lines 12 X-Factor Shoot the ball at the other factors to get a product of 12. You can also ...

Mr Clark

2012-10-31

5

Factorize  

NSDL National Science Digital Library

This interactive applet allows a student to visually explore the concept of factors by creating different rectangular arrays for a number. The user constructs the array by clicking and dragging on a grid. The length and width of the array are factors of the number. A student can elect an option of a randomly selected number or the student selects his own number between 2 and 50. Exploration questions are included to promote student discovery of mathematical concepts with factors.

2000-01-01

6

Diagrama Ti - V: una nueva propuesta de discriminación para magmas básicos en cinco ambientes tectónicos  

Microsoft Academic Search

RESUMEN Se presentan diagramas de discriminació n para magmas básicos (basaltos normativos en hiperstena, basaltos normativos en nefelina, y traquiandesita s basálticas normativas en nefelina), que tienen por objeto el distinguir entre cinco diferentes ambientes tectónicos: arco continental (AC); arco de isla (AI); rift (Rt); isla oceánica (IO) y basaltos de cresta mesoceánica (MOR); con base en los datos de

Manuel Vasconcelos-F; Surendra P. Verma; R. Carmen Vargas-B

7

Factor Trees  

NSDL National Science Digital Library

In this online activity, the learner finds the prime factorization of composite numbers by building factor trees. A second level includes finding the greatest common factor and the least common multiple by sorting factors using a Venn Diagram.

2010-01-01

8

Factor Trees  

NSDL National Science Digital Library

This virtual manipulative allows students to find the prime factorization of numbers by completing factor trees. Then they may use a venn diagram to sort the prime factors to find the greatest common factor and the least common multiple.

Math Playground

2009-07-29

9

Factor Findings  

NSDL National Science Digital Library

In this lesson, students first create factor posters for a variety of different numbers that will be displayed in the classroom to be utilized as a resource throughout the school year. They make discoveries about factors using color tiles, represent their discoveries using graph paper, and display their information on poster board as find factors of an assigned number. The plan includes a list of materials, questions, assessment options, and extensions.

Piecora, Jamie

2000-01-01

10

Transfer factor.  

PubMed

Transfer factor, a natural substance of the immune system, was discovered in 1949. More than 3,000 scientific articles have established it as an effective treatment for many diseases, usually those related to the immune system. In China, more than six million people have used transfer factor as a prophylaxis for hepatitis. Information on ordering articles on transfer factor, olive leaf extract, and coconut oil is included. PMID:11366549

1998-01-01

11

Factor Game  

NSDL National Science Digital Library

This is an interactive applet game exercises a student's factoring ability. A student can play against the computer or against a friend on grids containing the numbers 1-30, 1-49, or 1-100. Each player in turn chooses a number from the board, and then the opponent claims all of its remaining proper factors. A player's score is the sum of all the numbers and factors she/he has chosen. When there are no numbers remaining with unclaimed factors, the game ends and the player with the greater total is the winner.

Adapted with permission from "Prime Time: Factors and Multiples," Connected Mathematics Project, G. Lappan, J. Fey, W. Fitzgerald, S. Friel and E. Phillips

2000-01-01

12

Factor Dazzle  

NSDL National Science Digital Library

This interactive online game helps students develop fluency with identifying factors while fostering strategic thinking. A student can play against the computer or against a friend on a 6 by 6 grid containing the numbers 1-36. Each player in turn chooses a number from the board, and then the opponent claims all of its remaining proper factors. A player's score is the sum of all the numbers and factors she/he has chosen. When there are no numbers remaining with unclaimed factors, the game ends and the player with the greater total is the winner. This game is part of NCTM's Calculation Nation project (cataloged separately). Users may login as a guest and play against the computer, or register (free) to challenge other players online.

2011-01-01

13

Power Factor  

NSDL National Science Digital Library

All About Circuits is a website that â??provides a series of online textbooks covering electricity and electronics.â?ť Written by Tony R. Kuphaldt, the textbooks available here are wonderful resources for students, teachers, and anyone who is interested in learning more about electronics. This specific section, Power Factor, is the eleventh chapter in Volume II â??Alternating Current. A few of the topics covered in this chapter include: True, Reactive, and Apparent power; Calculating power factor, and Practical power factor correction. Diagrams and detailed descriptions of concepts are included throughout the chapter to provide users with a comprehensive lesson. Visitors to the site are also encouraged to discuss concepts and topics using the All About Circuits discussion forums (registration with the site is required to post materials).

Kuphaldt, Tony R.

14

Power Factor Compensation (PFC) Power Factor Compensation  

E-print Network

Power Factor Compensation (PFC) Power Factor Compensation The power factor (PF) is defined as the ratio between the active power and the apparent power of a system. If the current and voltage are periodic with period , and [ ), then the active power is defined by ( ) ( ) (their inner product

Knobloch,JĂĽrgen

15

Learning with matrix factorizations  

E-print Network

Matrices that can be factored into a product of two simpler matrices can serve as a useful and often natural model in the analysis of tabulated or high-dimensional data. Models based on matrix factorization (Factor Analysis, ...

Srebro, Nathan, 1974-

2004-01-01

16

Sparse matrix inverse factors  

SciTech Connect

The inverses of matrix factors lend themselves to parallel operations in the direct solution phase of sparse matrix solutions. These inverse factors, given suitable ordering of the equations, are themselves sparse, if less so than the original factors. Partitioning reduces the build-up of nonzero elements in the inverse factors. All of the multiplications required for repeat solutions may be performed in parallel using the inverse factors, with only as many serial steps as twice the number of factors.

Enns, M.K. (Electrocon International, Inc., Ann Arbor, MI (USA)); Tinney, W.F.; Alvarado, F.L. (Wisconsin Univ., Madison, WI (USA))

1990-05-01

17

Growth factors in bone  

Microsoft Academic Search

Summary.  \\u000a Bone contains several growth factors, including bone morphogenetic proteins (BMPs), transforming growth factor beta (TGF-?),\\u000a insulin-like growth factors I and II (IGF-I and IGF-II), platelet derived growth factor (PDGF) and basic and acidic fibroblast\\u000a growth factor (bFGF and aFGF). Spatial and temporal variations in the expression and secretion of the various growth factors\\u000a have been demonstrated in osteoblastic cultures

E. Solheim

1998-01-01

18

Factoring Polynomials and Fibonacci.  

ERIC Educational Resources Information Center

Discusses the factoring of polynomials and Fibonacci numbers, offering several challenges teachers can give students. For example, they can give students a polynomial containing large numbers and challenge them to factor it. (JN)

Schwartzman, Steven

1986-01-01

19

Important Water Quality Factors  

NSDL National Science Digital Library

This site provides basic information about factors commonly analyzed in water quality studies of drinking water, waste water and natural water. The factors are listed alphabetically with descriptions and explanations about what the results of measurements mean in environmental terms.

20

Factor V deficiency  

MedlinePLUS

... as many as 20 different proteins in blood plasma. These proteins are called blood coagulation factors. Factor ... You will be given fresh blood plasma or fresh frozen plasma infusions ... These treatments will correct the deficiency temporarily.

21

Multilevel Mixture Factor Models  

ERIC Educational Resources Information Center

Factor analysis is a statistical method for describing the associations among sets of observed variables in terms of a small number of underlying continuous latent variables. Various authors have proposed multilevel extensions of the factor model for the analysis of data sets with a hierarchical structure. These Multilevel Factor Models (MFMs)…

Varriale, Roberta; Vermunt, Jeroen K.

2012-01-01

22

Bayesian Exploratory Factor Analysis.  

PubMed

This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates from a high dimensional set of psychological measurements. PMID:25431517

Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J; Piatek, Rémi

2014-11-01

23

Exploratory Bi-Factor Analysis  

ERIC Educational Resources Information Center

Bi-factor analysis is a form of confirmatory factor analysis originally introduced by Holzinger. The bi-factor model has a general factor and a number of group factors. The purpose of this article is to introduce an exploratory form of bi-factor analysis. An advantage of using exploratory bi-factor analysis is that one need not provide a specific…

Jennrich, Robert I.; Bentler, Peter M.

2011-01-01

24

Nucleon form factors  

SciTech Connect

Nucleon elastic form factors parametrize the internal structure of the nucleon as probed by the electroweak force. In particular, they provide information on the distribution of nucleon charge among sea and valence quarks and on the distribution of flavor in the nucleon. The recent measurements are reviewed and new techniques to experimentally determine the form factors are described. Future plans at the new high duty-factor electron machines are discussed. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}.

Milner, R.G. [Bates Linear Accelerator Center and Laboratory for Nuclear Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139 (United States)

1995-07-10

25

Meson electromagnetic form factors  

E-print Network

The electromagnetic structure of the pseudoscalar meson nonet is completely described by the sophisticated Unitary&Analytic model, respecting all known theoretical properties of the corresponding form factors.

Stanislav Dubnicka; Anna Z. Dubnickova

2012-10-23

26

Overview of environmental factors  

NASA Technical Reports Server (NTRS)

The orbital environment is complex, dynamic, and comprised of both natural and system-induced components. Several environment factors are important for materials. Materials selection/suitability determination requires consideration of each and all factors, including synergisms among them. Understanding and evaluating these effects will require ground testing, modeling, and focused flight experimentation.

Purvis, C. K.

1989-01-01

27

Factorizing RSA Keys  

NASA Astrophysics Data System (ADS)

Factorization is notoriously difficult. Though the problem is not known to be NP-hard, neither efficient, algorithmic solution nor technologically practicable, quantum-computer solution has been found. This apparent complexity, which renders infeasible the factorization of sufficiently large values, makes secure the RSA cryptographic system.

Blakey, Ed

28

Vitiligo – Exogenous Factors  

Microsoft Academic Search

Vitiligo is an acquired depigmentary disorder of the skin that results from the selective destruction of melanocytes. The etiology of vitiligo is poorly understood. There appears to be a genetic predisposition, but additional factors are probably involved. The purpose of this article is to outline the factors that might play a role in the development of vitiligo. These include trauma

Hagit Matz; Ethel Tur

2004-01-01

29

Angiogenic factors and preeclampsia.  

PubMed

Preeclampsia is a major cause of maternal and neonatal morbidity and mortality worldwide. Although the etiology of preeclampsia is still unclear, recent studies suggest that its major phenotypes, hypertension and proteinuria, may be due to an excess of circulating anti-angiogenic growth factors, most notably soluble fms-like tyrosine kinase 1 (sFlt1) and soluble endoglin (sEng). sFlt1 is an endogenous protein that is produced by the placenta. sFlt1 is able to bind to the angiogenic growth factors vascular endothelial growth factor and placental growth factor, thereby neutralizing their functions. High serum concentrations of sFlt1 and low concentrations of free vascular endothelial growth factor and free placental growth factor have been observed during and prior to clinical manifestation of preeclampsia. More recently, serum levels of sEng were also shown to be significantly elevated in preeclamptic women and levels of sEng correlated strongly with disease severity. Therefore, measurement of sFlt1 and sEng in the maternal circulation may be a useful diagnostic and screening tool for preeclampsia. The availability of such a test to predict preeclampsia would have significant impact on current obstetrical care and may help reduce preeclampsia-induced morbidity and mortality. This review will focus on the role of angiogenic factors in normal and abnormal placental development and indicate how measurement of circulating angiogenic factors may help identify women at risk of preeclampsia. PMID:17127249

Tjoa, May Lee; Levine, Richard J; Karumanchi, S Ananth

2007-01-01

30

Perturbative QCD factorization of ?????  

NASA Astrophysics Data System (ADS)

In this paper, we firstly verify that the factorization hypothesis is valid for the exclusive process ????? at the next-to-leading order (NLO) with the collinear factorization approach, and then extend this proof to the case of the kT factorization approach. We particularly show that at the NLO level, the soft divergences in the full quark level calculation could be canceled completely as for the ????? process where only the pseudoscalar ? meson is involved, and the remaining collinear divergences can be absorbed into the NLO hadron wave functions. The full amplitudes can be factorized as the convolution of the NLO wave functions and the infrared-finite hard kernels with these factorization approaches. We also write out the NLO meson distribution amplitudes in the form of nonlocal matrix elements.

Cheng, Shan; Xiao, Zhen-Jun

2014-10-01

31

SU3 isoscalar factors  

E-print Network

A summary of the properties of the Wigner Clebsch-Gordan coefficients and isoscalar factors for the group SU3 in the SU2$\\otimes$U1 decomposition is presented. The outer degeneracy problem is discussed in detail with a proof of a conjecture (Braunschweig's) which has been the basis of previous work on the SU3 coupling coefficients. Recursion relations obeyed by the SU3 isoscalar factors are produced, along with an algorithm which allows numerical determination of the factors from the recursion relations. The algorithm produces isoscalar factors which share all the symmetry properties under permutation of states and conjugation which are familiar from the SU2 case. The full set of symmetry properties for the SU3 Wigner-Clebsch-Gordan coefficients and isoscalar factors are displayed.

H. Thomas Williams

1995-10-06

32

Factors augmenting allergic reactions.  

PubMed

Elicitors of anaphylactic reactions are any sources of protein with allergenic capacity. However, not all allergic reactions end up in the most severe form of anaphylaxis. Augmenting factors may explain why certain conditions lead to anaphylaxis. Augmenting factors may exhibit three effects: lowering the threshold, increasing the severity, and reversing acquired clinical tolerance. Common augmenting factors are physical exercise, menstruation, NSAIDs, alcohol, body temperature, acute infections, and antacids. Therapeutic options may address causative, preventive, pragmatic, or symptomatic considerations: avoid the eliciting food, take an antihistamine before any situation with a possible risk of augmentation, separate food and sport (at least for 2 h), and carry an adrenaline autoinjector at all times. Individual patterns include summation effects and specific patterns. In conclusion, in the case of a suggestive history but a negative oral challenge, one should consider the possible involvement of augmenting factors; after anaphylactic reactions, always ask for possible augmentation and other risk factors during the recent past; if augmentation is suspected, oral food challenges should be performed in combination with augmenting factors; and in the future, standardized challenge protocols including augmenting factors should be established. PMID:25306896

Niggemann, B; Beyer, K

2014-12-01

33

Environmental Factors in Autism  

PubMed Central

Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an important area of research and recent data will be discussed in this review. Interestingly, the results show that many environmental risk factors are interrelated and their identification and comparison might unveil a common scheme of alterations on a contextual as well as molecular level. For example, both, disruption in the immune system and in zinc homeostasis may affect synaptic transmission in autism. Thus, here, a model is proposed that interconnects the most important and scientifically recognized environmental factors. Moreover, similarities in how these risk factors impact synapse function are discussed and a possible influence on an already well described genetic pathway leading to the development of autism via zinc homeostasis is proposed. PMID:23346059

Grabrucker, Andreas M.

2013-01-01

34

Teleoperator human factors study  

NASA Technical Reports Server (NTRS)

The progress made on the Teleoperator Human Factors Study program is summarized. Technical and programmatic problems that were encountered were discussed along with planned activities. The report contains four sections: Work Performed, Future Work, Problems Encountered, and Cost Information

1984-01-01

35

Teleoperator human factors study  

NASA Technical Reports Server (NTRS)

The progress made on the Teleoperator Human Factors Study program is summarized. Technical and programmatic problems that were encountered are discussed along with planned activity. Work performed, future work, problems encountered, and cost information comprise the topics addressed herein.

1984-01-01

36

Aerospace Human Factors  

NASA Technical Reports Server (NTRS)

The following contains the final report on the activities related to the Cooperative Agreement between the human factors research group at NASA Ames Research Center and the Psychology Department at San Jose State University. The participating NASA Ames division has been, as the organization has changed, the Aerospace Human Factors Research Division (ASHFRD and Code FL), the Flight Management and Human Factors Research Division (Code AF), and the Human Factors Research and Technology Division (Code IH). The inclusive dates for the report are November 1, 1984 to January 31, 1999. Throughout the years, approximately 170 persons worked on the cooperative agreements in one capacity or another. The Cooperative Agreement provided for research personnel to collaborate with senior scientists in ongoing NASA ARC research. Finally, many post-MA/MS and post-doctoral personnel contributed to the projects. It is worth noting that 10 former cooperative agreement personnel were hired into civil service positions directly from the agreements.

Jordan, Kevin

1999-01-01

37

Factor II deficiency  

MedlinePLUS

... factor II deficiency is caused by: Lack of vitamin K due to long-term use of antibiotics, bile duct obstruction , or poor absorption of vitamin K from the intestines. Some babies are born with ...

38

Factor VIII assay  

MedlinePLUS

Decreased levels may be due to: Disseminated intravascular coagulation (DIC) Hemophilia A Presence of a Factor VIII inhibitor (antibody) Von Willebrand's disease Increased levels may be due to: Advanced age Diabetes ...

39

Rheumatoid Factors: Clinical Applications  

PubMed Central

Rheumatoid factors are antibodies directed against the Fc region of immunoglobulin G. First detected in patients with rheumatoid arthritis 70 years ago, they can also be found in patients with other autoimmune and nonautoimmune conditions, as well as in healthy subjects. Rheumatoid factors form part of the workup for the differential diagnosis of arthropathies. In clinical practice, it is recommended to measure anti-cyclic citrullinated peptide antibodies and rheumatoid factors together because anti-cyclic citrullinated peptide antibodies alone are only moderately sensitive, and the combination of the two markers improves diagnostic accuracy, especially in the case of early rheumatoid arthritis. Furthermore, different rheumatoid factor isotypes alone or in combination can be helpful when managing rheumatoid arthritis patients, from the time of diagnosis until deciding on the choice of therapeutic strategy. PMID:24324289

Castelli, Roberto

2013-01-01

40

New microbial growth factor  

NASA Technical Reports Server (NTRS)

A screening procedure was used to isolate from soil a Penicillium sp., two bacterial isolates, and a Streptomyces sp. that produced a previously unknown microbial growth factor. This factor was an absolute growth requirement for three soil bacteria. The Penicillium sp. and one of the bacteria requiring the factor, an Arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. It did not seem to be related to the siderochromes. It was not present in soil extract, rumen fluid, or any other medium component tested. It appears to be a glycoprotein of high molecular weight and has high specific activity. When added to the diets for a meadow-vole mammalian test system, it caused an increased consumption of diet without a concurrent increase in rate of weight gain.

Bok, S. H.; Casida, L. E., Jr.

1977-01-01

41

Factor X deficiency  

MedlinePLUS

In: Hoffman R, Benz EJ Jr., Shattil SJ, et al, eds. Hoffman Hematology: Basic Principles and Practice . 5th ed. Philadelphia, ... D, Neff AT. Rare coagulation factor deficiencies In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, ...

42

Factors Affecting Wound Healing  

PubMed Central

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds. PMID:20139336

Guo, S.; DiPietro, L.A.

2010-01-01

43

Environmental factors and psoriasis.  

PubMed

Psoriasis is a chronic relapsing disease characterized by variable clinical features. Several factors may exacerbate its manifestations, or even trigger the disease, such as traumatic injury to the skin, physical and psychological stress, cold weather, excessive alcohol intake, and drugs such as lithium and Beta-blockers. We describe the most common features of psoriasis and the exogenous factors that may induce, trigger or exacerbate the disease. PMID:17641494

Dika, E; Bardazzi, F; Balestri, R; Maibach, H I

2007-01-01

44

FGF growth factor analogs  

DOEpatents

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2012-07-24

45

Interest rates factor model  

NASA Astrophysics Data System (ADS)

Interdependence of the interest rates of the US, the UK, and Japan is analyzed in this work by means of spectral analysis and network methods. A predominant effective factor in the interest rate market is which country floats a bond issue, and a minor effective factor is time to maturity of bonds. Power-law cross-correlation among different countries is analyzed by the detrended cross-correlation analysis method. Long-range cross-correlation is found between the first factors of interest rate, while there is no cross-correlation between some of the second factors. The tail dependency is indicated by tail indices from Archimedean copulas, including an empirical copula. In contrast to other pairs, the US-UK first factor pair has tail dependencies in both the upper-tail and lower-tail. Dynamic properties of interest rate are modeled by a stochastic volatility model. The properties of mean reverting and volatility clustering are observed and reflected in this model. The proposed simulation method combines the dependence structures and the factor dynamics model; it simultaneously describes the interest rates of different countries.

Lee, Sangwook; Kim, Min Jae; Kim, Soo Yong

2011-07-01

46

Compilted Quantum Factoring Circuits  

NASA Astrophysics Data System (ADS)

Shor's factoring algorithm is held as one of the most promising and useful applications of quantum computing. It allows one to factor large numbers in polynomial time, undermining the most common cryptographic schemes in use today, such as RSA cryptography. The well known algorithm is based on the quantum fourier transform to find the period of a function, and also makes heavy use of the modular exponentiation operation, given by, U:a0 ->ax^a(mod N), where N is the number to be factored, and x is a random positive integer coprime with N. The modular exponentiation is the bottleneck of the algorithm, the portion that uses the most time. The generic algorithm can factorize any N in time order (N)^3, assuming sufficient memory space for intermediate calculations. Reducing the memory available (as long as it still lies above a certain threshold) increases the time taken by multiplicative factors, keeping its order the same in (N). However, for a given N, or class of N's to factorize, the generic algorithm may be suboptimal, and can be optimized to result in substantial savings in both memory needed and operation time. The different suboperations involved in modular exponentiat

Gamel, Omar; James, Daniel

2013-03-01

47

Factor Loading Estimation Error and Stability Using Exploratory Factor Analysis  

ERIC Educational Resources Information Center

Exploratory factor analysis (EFA) is commonly employed to evaluate the factor structure of measures with dichotomously scored items. Generally, only the estimated factor loadings are provided with no reference to significance tests, confidence intervals, and/or estimated factor loading standard errors. This simulation study assessed factor loading…

Sass, Daniel A.

2010-01-01

48

Factor Analysis and Counseling Research  

ERIC Educational Resources Information Center

Topics discussed include factor analysis versus cluster analysis, analysis of Q correlation matrices, ipsativity and factor analysis, and tests for the significance of a correlation matrix prior to application of factor analytic techniques. Techniques for factor extraction discussed include principal components, canonical factor analysis, alpha…

Weiss, David J.

1970-01-01

49

Recursive inverse factorization.  

PubMed

A recursive algorithm for the inverse factorization S(-1)=ZZ(*) of Hermitian positive definite matrices S is proposed. The inverse factorization is based on iterative refinement [A.M.N. Niklasson, Phys. Rev. B 70, 193102 (2004)] combined with a recursive decomposition of S. As the computational kernel is matrix-matrix multiplication, the algorithm can be parallelized and the computational effort increases linearly with system size for systems with sufficiently sparse matrices. Recent advances in network theory are used to find appropriate recursive decompositions. We show that optimization of the so-called network modularity results in an improved partitioning compared to other approaches. In particular, when the recursive inverse factorization is applied to overlap matrices of irregularly structured three-dimensional molecules. PMID:18345875

Rubensson, Emanuel H; Bock, Nicolas; Holmström, Erik; Niklasson, Anders M N

2008-03-14

50

DSN human factors project  

NASA Technical Reports Server (NTRS)

The project plan was to hold focus groups to identify the factors influencing the ease of use characteristics of software and to bond the problem. A questionnaire survey was conducted to evaluate those factors which were more appropriately measured with that method. The performance oriented factors were analyzed and relationships hypothesized. The hypotheses were put to test in the experimental phase of the project. In summary, the initial analysis indicates that there is an initial performance effect favoring computer controlled dialogue but the advantage fades fast as operators become experienced. The user documentation style is seen to have a significant effect on performance. The menu and prompt command formats are preferred by inexperienced operators. The short form mnemonic is least favored. There is no clear best command format but the short form mnemonic is clearly the worst.

Chafin, R. L.; Martin, T. H.

1980-01-01

51

Psychological Factors in Asthma  

PubMed Central

Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and symptom reporting. Emerging evidence suggests that the relation between asthma and psychological factors may be more complex than that, however. Central cognitive processes may influence not only the interpretation of asthma symptoms but also the manifestation of measurable changes in immune and physiologic markers of asthma. Furthermore, asthma and major depressive disorder share several risk factors and have similar patterns of dysregulation in key biologic systems, including the neuroendocrine stress response, cytokines, and neuropeptides. Despite the evidence that depression is common in people with asthma and exerts a negative impact on outcome, few treatment studies have examined whether improving symptoms of depression do, in fact, result in better control of asthma symptoms or improved quality of life in patients with asthma. PMID:20525122

2008-01-01

52

Antiretroviral Restriction Factors  

PubMed Central

Studies of retroviruses have been instrumental in revealing the existence of an array of antiviral proteins, or restriction factors, and the mechanisms by which they function. Some restriction factors appear to specifically inhibit retrovirus replication, while others have a broader antiviral action. Here, we briefly review current understanding of the mechanisms by which several such proteins exert antiviral activity. We also discuss how retroviruses have evolved to evade or antagonize antiviral proteins, including through the action of viral accessory proteins. Restriction factors, their viral targets and antagonists have exerted evolutionary pressure on each other, resulting in specialization and barriers to cross-species transmission. Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit. PMID:22278313

Hatziioannou, Theodora; Bieniasz, Paul D.

2011-01-01

53

Multi-factor authentication  

DOEpatents

Detection and deterrence of spoofing of user authentication may be achieved by including a cryptographic fingerprint unit within a hardware device for authenticating a user of the hardware device. The cryptographic fingerprint unit includes an internal physically unclonable function ("PUF") circuit disposed in or on the hardware device, which generates a PUF value. Combining logic is coupled to receive the PUF value, combines the PUF value with one or more other authentication factors to generate a multi-factor authentication value. A key generator is coupled to generate a private key and a public key based on the multi-factor authentication value while a decryptor is coupled to receive an authentication challenge posed to the hardware device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

Hamlet, Jason R; Pierson, Lyndon G

2014-10-21

54

Health factors in colostrum.  

PubMed

Colostrum is a breast milk produced after the birth of the newborn and lasts for 2-4 days. Colostrum is very important part of breast milk and lays down the immune system and confers growth factors and other protective factors for the young ones in mammals. This is the source of passive immunity achieved by the mother and is transferred to the baby. This is the major source of secretory IgA and gives protection against gastrointestinal infections. In view of so many health factors through colostrum, the use of colostrum has been extended to so many health problems of mankind. Human and bovine colostrums have many similarities barring that bovine colostrum can be obtained in large quantity, so bovine colostrum has been used in various disorders in human beings. This is the nature's gift that is for the young ones to grow as well as for the treatment of many health problems in older age group. PMID:16077241

Thapa, B R

2005-07-01

55

Role of human factor VIII in factor X activation.  

PubMed Central

The cofactor function of human Factor VIII in Factor X activation was investigated by an initial-rate assay of 3H-Factor X activation in the presence of human factor IXa, Ca2+, and either phospholipid or fresh washed human platelets. Purified Factor VIII that has not been activated by thrombin or Factor Xa supports Factor X activation after a lag of several minutes. A specific inhibitor of Factor Xa, which had no inhibitory activity against Factor IXa, markedly prolonged this lag, whereas specific thrombin inhibitors did not prolong the lag. These data support the conclusion that unactivated Factor VIII has no ability to support Factor X activation in a purified system until it is activated by Factor Xa feedback during the lag period. When Factor VIII was optimally preactivated by thrombin, the lag was completely abolished, regardless of the order of addition of the other reactants or the phospholipid source. These data indicate that there is no slow, time-dependent ordering of the reactants at the phospholipid or activated platelet surface if Factor VIII has been preactivated. Unactivated platelets did not support Factor X activation by Factors IXa and VIII. The effect of activated Factor VIII on the kinetics of bovine Factor X activation was primarily to increase the Vmax (54-fold), whereas with human Factor X, Factor VIII both increased the Vmax 56-fold and decreased the Km sixfold to 0.14 microM, similar to the plasma concentration of Factor X. Therefore, a change in the plasma factor X concentration would be expected to have a major effect on the rate of Factor X activation in vivo. PMID:6804496

Hultin, M B

1982-01-01

56

Power Factor Improvement  

E-print Network

and Dr. Russell Heiser mann, School of Technology, Electrical Power Department. 1032 ESL-IE-79-04-121 Proceedings from the First Industrial Energy Technology Conference Houston, TX, April 22-25, 1979 I 3. Total Olrrent - (apparent power... is the power factor of the load on a 460 volt, 3 phase system if the annneter indicates 110 amperes and the wattmeter reads 60 KW? Since in a 3-phase circuit: KVA = 3 volts' amperes = 1.73 * 460 * 110 87.54 1000 1000 Power factor = ~V = 60 = .685 or 68...

Viljoen, T. A.

1979-01-01

57

Growth factors in bone repair  

Microsoft Academic Search

The role of growth factors (GF) in bone repair is widely recognised, particularly for bone morphogenetic proteins (BMPs),\\u000a fibroblast growth factor (FGF), insulin-like growth factors (IGFs), platelet-derived growth factor (PDGF), transforming growth\\u000a factor-? (TGF-?) and vascular endothelial growth factor (VEGF). GF are usually stored in the extracellular matrix (ECM), but\\u000a after injury are actively released by ECM, cells and platelets.

Valentina Devescovi; Elisa Leonardi; Gabriela Ciapetti; Elisabetta Cenni

2008-01-01

58

Optimal power factor correction  

SciTech Connect

This paper discusses the different parameters affecting the economic feasibility of power factor correction. It will be shown that the specific costs of the transmission and compensation elements as well as those of the electric energy and power losses have a decisive influence on the achievable overall saving. After formulating an objective function representing this overall saving, taking also the load factor into account an analytical approach to the determination of the optimal size of the compensation equipment is presented. A generalized chart is given which enables the designer to know whether the power factor correction is feasible or not under any circumstances. Also, the most suitable degree of reactive power compensation can be directly found. The results obtained from a digital program are also given to indicate the sensitivity of the optimal compensation factor to changes in system parameters such as the specific energy loss cost and the annual rate of interest and depreciation. Moreover, the good agreement of the results of the digital computation with those determined using the suggested simple generalized chart, could be realized.

Mostafa, M. (Electrical and Computer Engineering Dept., College of Engineering and Petroleum, Kuwait Univ. (KW))

1988-08-01

59

Factor Trail Game  

NSDL National Science Digital Library

In this math game, learners identify the factors of a number to earn points. Although practicing a mundane skill, learners enjoy the work because of the game scenario. Built into this game is cooperative learning--learners check one another's work before points are awarded. This lesson guide includes questions for learners, assessment options, extensions, and reflection questions.

2008-01-01

60

Introduction to human factors  

SciTech Connect

Some background is given on the field of human factors. The nature of problems with current human/computer interfaces is discussed, some costs are identified, ideal attributes of graceful system interfaces are outlined, and some reasons are indicated why it's not easy to fix the problems. (LEW)

Winters, J.M.

1988-03-01

61

Computing nonnegative tensor factorizations  

E-print Network

Oct 19, 2006 ... an approximation of V. A vital property of the NTF is that each factor is also nonnegative. ..... of l1 regularization include signal processing for the recovery of sparse signals; see, e.g., ..... Robust uncertainty principles: Exact.

2006-10-18

62

Robust Bayesian Factor Analysis  

ERIC Educational Resources Information Center

Bayesian factor analysis (BFA) assumes the normal distribution of the current sample conditional on the parameters. Practical data in social and behavioral sciences typically have significant skewness and kurtosis. If the normality assumption is not attainable, the posterior analysis will be inaccurate, although the BFA depends less on the current…

Hayashi, Kentaro; Yuan, Ke-Hai

2003-01-01

63

Teleoperator human factors study  

NASA Technical Reports Server (NTRS)

The progress made on the Teleoperator Human Factors Study program during the period of September 7, 1985 to October 6, 1985 is discussed. Technical and programmatic problems that were encountered are discussed along with activity planned for the following month. The main portion of the report has been separated into four sections: Work Performed, Future Work, Problems Encountered, and Cost Information.

Bradford, K. Z.; Schappell, R. T.

1985-01-01

64

A Formula for Factoring.  

ERIC Educational Resources Information Center

Suggests use of the quadratic formula to build understanding that connections between factors and solutions to equations work both ways. Making use of natural connections among concepts allows students to work more efficiently. Presents four sample problems showing the roots of equations. Messy quadratic equations with rational roots can be solved…

Roebuck, Kay I. Meeks

1997-01-01

65

Factors Influencing Professorial Assessment.  

ERIC Educational Resources Information Center

The Oregon State System of Higher Education recently completed a 3-year study entitled Faculty Teaching: Models for Assessment of Quality. Over 400 teaching and administrative faculty selected on a random or stratified basis answered the following questions: (1) What factors are considered in the assessment of faculty performance? (2) What…

Scott, Craig S.; And Others

66

Scale Factor X  

NSDL National Science Digital Library

In this game, students navigate a maze to get to a math challenge. The three challenges are: move blue and green "fuel cells" around to match the ratios in the given containers; measure shapes to determine the scale factors needed to make them match the given templates; determine how to place bases on a map based on clues involving proportions.

2010-01-01

67

Nucleon electromagnetic form factors  

SciTech Connect

A review of data on the nucleon electromagnetic form factors in the space-like region is presented. Recent results from experiments using polarized beams and polarized targets or nucleon recoil polarimeters have yielded a significant improvement on the precision of the data obtained with the traditional Rosenbluth separation. Future plans for extended measurements are outlined.

Kees de Jager

2000-01-01

68

Factors Affecting Photosynthesis!  

E-print Network

Factors Affecting Photosynthesis! Temperature Eppley (1972) Light Sverdrup's Critical Depth-493, but the general concept is still valid! ! #12;PB opt & Temperature! #12;Photosynthesis & Temperature! Remember: in the laboratory, we can measure photosynthesis versus irradiance (PvsE) and calculate Ek, Pmax, and alpha

Kudela, Raphael M.

69

Factors Predicting Educational Productivity.  

ERIC Educational Resources Information Center

Since 1968 educational productivity studies at the University of Florida have been analyzing data from six States and one city. Linear regression was used to identify high and low productive units by measuring the relationship between statistically selected input factors and a measure of student achievement. Discriminant analysis was employed to…

Hanes, Carol E.; Jordan, K. Forbis

70

Projectile Motion (factoring quadratics)  

NSDL National Science Digital Library

Students use the internet to research values relevant to projectile motion such as acceleration due to gravity and the height of objects. Using the given information students will have to make unit conversions to ensure that all units are the same. They will then solve problems on projectile motion by factoring.

2010-01-01

71

FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES  

EPA Science Inventory

General guidance for designing field studies to measure bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs) is not available. To develop such guidance, a series of modeling simulations were performed to evaluate the underlying factors and principles th...

72

FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES  

EPA Science Inventory

A series of modeling simulations were performed to develop an understanding of the underlying factors and principles involved in developing field sampling designs for measuring bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs. These simulations reveal...

73

Risk Factors for Eating Disorders  

Microsoft Academic Search

The authors review research on risk factors for eating disorders, restricting their focus to studies in which clear precedence of the hypothesized risk factor over onset of the disorder is established. They illustrate how studies of sociocultural risk factors and biological factors have progressed on parallel tracks and propose that major advances in understanding the etiology of eating disorders require

Ruth H. Striegel-Moore; Cynthia M. Bulik

2007-01-01

74

Journal Information Journal Impact Factor  

E-print Network

Journal Information Journal Impact Factor 5-Year Journal Impact Factor Journal Self Cites Journal Immediacy Index Journal Cited Half-Life 2012 JCR Science Edition Journal: CZECHOSLOVAK MATHEMATICAL JOURNAL Mark Journal Title ISSN Total Cites Impact Factor 5-Year Impact Factor Immediacy Index Citable Items

KrejcĂ­, Pavel

75

Risk Factors for Eating Disorders  

ERIC Educational Resources Information Center

The authors review research on risk factors for eating disorders, restricting their focus to studies in which clear precedence of the hypothesized risk factor over onset of the disorder is established. They illustrate how studies of sociocultural risk factors and biological factors have progressed on parallel tracks and propose that major advances…

Striegel-Moore, Ruth H.; Bulik, Cynthia M.

2007-01-01

76

[Streptococcus pyogenes pathogenic factors].  

PubMed

The pathogenicity of ß-hemolytic group A streptococcus (GAS) is particularly diverse, ranging from mild infections, such as pharyngitis or impetigo, to potentially debilitating poststreptococcal diseases, and up to severe invasive infections such as necrotizing fasciitis or the dreaded streptococcal toxic shock syndrome. This variety of clinical expressions, often radically different in individuals infected with the same strain, results from a complex interaction between the bacterial virulence factors, the mode of infection and the immune system of the host. Advances in comparative genomics have led to a better understanding of how, following this confrontation, GAS adapts to the immune system's pressure, either peacefully by reducing the expression of certain virulence factors to achieve an asymptomatic carriage, or on the contrary, by overexpressing them disproportionately, resulting in the most severe forms of invasive infection. PMID:25456681

Bidet, Ph; Bonacorsi, S

2014-11-01

77

Human factors workplace considerations  

NASA Technical Reports Server (NTRS)

Computer workstations assume many different forms and play different functions today. In order for them to assume the effective interface role which they should play they must be properly designed to take into account the ubiguitous human factor. In addition, the entire workplace in which they are used should be properly configured so as to enhance the operational features of the individual workstation where possible. A number of general human factors workplace considerations are presented. This ongoing series of notes covers such topics as achieving comfort and good screen visibility, hardware issues (e.g., mouse maintenance), screen symbology features (e.g., labels, cursors, prompts), and various miscellaneous subjects. These notes are presented here in order to: (1) illustrate how one's workstation can be used to support telescience activities of many other people working within an organization, and (2) provide a single complete set of considerations for future reference.

Haines, Richard F.

1988-01-01

78

Atomic Scattering Factors  

NSDL National Science Digital Library

From the Lawrence Berkeley Laboratory's Center for X-Ray Optics, these "atomic scattering factors are based upon photoabsorption measurements of elements in their elemental state." These easy-to-use tables allow users to search out atomic scattering factor data by element and look up the x-ray properties of elements, the index of refraction for a compound material, the x-ray attenuation length of a solid, the x-ray transmission of a solid or a gas, and more. Most of the tables are accessed by way of an online query form with variables such as material, density, and photon energy range entered by the user. Most outputs come in plot form for quick viewing, or results may be retrieved as a text or postscript file for use with a personal plotting software.

79

Factors regulating microglia activation  

PubMed Central

Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the “resting” but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2). Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies. In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence. PMID:23630462

Kierdorf, Katrin; Prinz, Marco

2013-01-01

80

Factor Trail Game  

NSDL National Science Digital Library

In this math game, learners identify the factors of a number to earn points. The score sheet used for this game provides a built-in assessment tool that teachers can use to check their students' understanding. This game also provides an opportunity for cooperative learning--learners check one another's work before points are awarded. This lesson guide includes questions for learners, assessment options, extensions, and reflection questions.

Vennebush., G. P.

2008-01-01

81

The Fas Death Factor  

Microsoft Academic Search

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction

Shigekazu Nagata; Pierre Golstein

1995-01-01

82

Human Factors Review Plan  

SciTech Connect

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01

83

Radiant-interchange configuration factors  

E-print Network

. Derivation of the Configuration Factor 2. The Configuration Factor for Two Joined Rectangles 3. The Configuration Factor for Two Detached Rectangles . . . . . ~ . . . ~ , 12 III. METHODS OF SOLUTION 1. Simpson's One-Third Rule 2. Grid Method 3... TABLE I, Configuration Factors for Two Joined Rectangles II. Percent Difference and Time Figures for Two Joined Rectangles III. Configuration Factors for Two Detached Rectangles PAGE 25 25 ~ ~ ~ ~ 26 vi LIST OF FIGURES FIGURE PAGE 2. 1 2...

Reddin, Thomas Edward

1965-01-01

84

Tissue factor and atherothrombosis.  

PubMed

Tissue factor (TF) is known to be the key element in the initiation of the extrinsic pathway of the coagulation cascade and appears to be a critical determinant of atherosclerotic plaque thrombogenicity. TF is needed to produce thrombin from prothrombin. In the extrinsic pathway, TF activates factor Vll. TF is expressed mainly on subendothelial tissues, but TF expression may be induced on endothelial cells by inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha). Subendothelial TF is responsible for initiating fibrin formation at sites of vascular injury, bloodborne TF may be an important contributor to propagation of the developing thrombus. It has been postulated that the blood-borne TF initiates the thrombogenic stimulus, leading to the formation of larger and more stable thrombus. TF may attach to cellular receptors, which in turn affect the production and release of inflammatory mediators. Baseline plasma TF activity has been demonstrated as an independent predictor for cardiovascular death in patients with acute myocardial infarction. TF is expressed by macrophage-derived foam cells in atherosclerotic plaques. TF levels were higher in atheroma from patients with unstable angina than with stable angina. These results suggest that high levels of TF exposed upon plaque rupture trigger atherothrombosis. Inhibition of TF would be expected to reduce thrombosis associated with a variety of diseases. TF pathway is a potential target for new therapeutic agents that can decrease TF activity, such as active site-inactivated factor VIIa, recombinant TF inhibitor and antibodies against TF or peptides interfering with TF-FVIIa complex activity. Significant clinical forms of atherosclerosis, such as sudden death, myocardial infarction, and stroke have common pathogenesis. The occlusion of the vessel lumen is the result from atherosclerotic plaque rupture/erosion that initiate thrombus formation. This thrombus has complex structure and contains predominantly fibrin in addition to platelets, suggesting an important role for the coagulation cascade in plaque thrombus formation. Tissue factor (TF) is known to be the key element in the initiation of the extrinsic pathway of the coagulation cascade and appears to be a critical determinant of atherosclerotic plaque thrombogenicity. PMID:25312727

Saha, D; S, Saha; Sergeeva, E G; Ionova, Z I; Gorbach, A V

2015-01-01

85

Neurotrophic factors and neurologic disease.  

PubMed Central

Discovered only 40 years ago, nerve growth factor is the prototypic neurotrophic factor. By binding to specific receptors on certain neurons in the peripheral nervous system and brain, nerve growth factor acts to enhance their survival, differentiation, and maintenance. In recent years, many additional neurotrophic factors have been discovered; some are structurally related to nerve growth factor while others are distinct from it. The robust actions of neurotrophic factors have suggested their use in preventing or lessening the dysfunction and death of neurons in neurologic disorders. We review the progress in defining neurotrophic factors and their receptors and in characterizing their actions. We also discuss some of the uses of neurotrophic factors in animal models of disease. Finally, we discuss how neurotrophic factors could be implicated in the pathogenesis of neurologic disorders. Images PMID:7975562

Holtzman, D M; Mobley, W C

1994-01-01

86

Neutron quality factor  

SciTech Connect

Both the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) have recommended that the radiation quality weighting factor for neutrons (Q{sub n}, or the corresponding new modifying factor, w{sub R}) be increased by a value of two for most radiation protection practices. This means an increase in the recommended value for Q{sub n} from a nominal value of 10 to a nominal value of 20. This increase may be interpreted to mean that the biological effectiveness of neutrons is two times greater than previously thought. A decision to increase the value of Q{sub n} will have a major impact on the regulations and radiation protection programs of Federal agencies responsible for the protection of radiation workers. Therefore, the purposes of this report are: (1) to examine the general concept of {open_quotes}quality factor{close_quotes} (Q) in radiation protection and the rationale for the selection of specific values of Q{sub n}; and (2) to make such recommendations to the Federal agencies, as appropriate. This report is not intended to be an exhaustive review of the scientific literature on the biological effects of neutrons, with the aim of defending a particular value for Q{sub n}. Rather, the working group examined the technical issues surrounding the current recommendations of scientific advisory bodies on this matter, with the aim of determining if these recommendations should be adopted by the Federal agencies. Ultimately, the group concluded that there was no compelling basis for a change in Q{sub n}. The report was prepared by Federal scientists working under the auspices of the Science Panel of the Committee on Interagency Radiation Research and Policy Coordination (CIRRPC).

NONE

1995-06-01

87

Factor-multiple Chains  

NSDL National Science Digital Library

This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

2007-04-01

88

Stress intensity factors  

SciTech Connect

In this work the concept of the stress intensity factor, the underlying mechanics problem leading to its emergence, and its physical relevance, particularly its relation to fracture mechanics are discussed. The reasons as to why it has become nearly an indispensable tool for studying such important phenomena as brittle fracture and fatigue or corrosion fatigue crack propagation in structural solids are considered. A brief discussion of some of the important methods of solution of elastic crack problems is given. Also, a number of related special mechanics problems are described. 24 references.

Erdogan, F.

1983-12-01

89

The "impact factor" revisited  

PubMed Central

The number of scientific journals has become so large that individuals, institutions and institutional libraries cannot completely store their physical content. In order to prioritize the choice of quality information sources, librarians and scientists are in need of reliable decision aids. The "impact factor" (IF) is the most commonly used assessment aid for deciding which journals should receive a scholarly submission or attention from research readership. It is also an often misunderstood tool. This narrative review explains how the IF is calculated, how bias is introduced into the calculation, which questions the IF can or cannot answer, and how different professional groups can benefit from IF use. PMID:16324222

Dong, Peng; Loh, Marie; Mondry, Adrian

2005-01-01

90

Factors in risk perception  

PubMed

Risk perception is a phenomenon in search of an explanation. Several approaches are discussed in this paper. Technical risk estimates are sometimes a potent factor in accounting for perceived risk, but in many important applications it is not. Heuristics and biases, mainly availability, account for only a minor portion of risk perception, and media contents have not been clearly implicated in risk perception. The psychometric model is probably the leading contender in the field, but its explanatory value is only around 20% of the variance of raw data. Adding a factor of "unnatural risk" considerably improves the psychometric model. Cultural Theory, on the other hand, has not been able to explain more than 5-10% of the variance of perceived risk, and other value scales have similarly failed. A model is proposed in which attitude, risk sensitivity, and specific fear are used as explanatory variables; this model seems to explain well over 30-40% of the variance and is thus more promising than previous approaches. The model offers a different type of psychological explanation of risk perception, and it has many implications, e.g., a different approach to the relationship between attitude and perceived risk, as compared with the usual cognitive analysis of attitude. PMID:10795334

Sjoberg

2000-02-01

91

[Crohn's disease - etiopathogenetic factors].  

PubMed

Crohn's disease is often purely inflammatory, but most patients develop complicated disease with strictures or fistulae. Specific etiopathogenesis of this severe disease is not definitely clear despite research efforts and learning of many pathogenetic mechanisms. Many studies have suggested that NOD2 mutations are associated with increased risk of complicated disease. Presence of NOD2 mutation itself is just one of factors contributing to development of this disease. Genetically predisposed individuals in combination with influence of environmental factors result in a disturbed innate (i.e., disturbed intestinal barrier, Paneth cell dysfunction) and adaptive (i.e., imbalance of effector and regulatory T cells and cytokines, migration and retention of leukocytes) immune response towards a diminished diversity of commensal microbiota. Data of meta-analysis made so far provide ambiguous evidence to support top-down therapy based solely on single NOD2 mutations, but suggest that targeted early-intensive therapy for high-risk patients with two NOD2 mutations might be beneficial, but more prospective trials could answer these questions. PMID:25130642

Kupka, Tomáš; Símová, Jarmila; Martínek, Lubomír; Svoboda, Pavel; Klva?a, Pavel; Bojková, Martina; Uvírová, Magdalena; Dovrt?lová, Lenka; Dít?, Petr

2014-01-01

92

SARSCEST (human factors)  

NASA Technical Reports Server (NTRS)

People interact with the processes and products of contemporary technology. Individuals are affected by these in various ways and individuals shape them. Such interactions come under the label 'human factors'. To expand the understanding of those to whom the term is relatively unfamiliar, its domain includes both an applied science and applications of knowledge. It means both research and development, with implications of research both for basic science and for development. It encompasses not only design and testing but also training and personnel requirements, even though some unwisely try to split these apart both by name and institutionally. The territory includes more than performance at work, though concentration on that aspect, epitomized in the derivation of the term ergonomics, has overshadowed human factors interest in interactions between technology and the home, health, safety, consumers, children and later life, the handicapped, sports and recreation education, and travel. Two aspects of technology considered most significant for work performance, systems and automation, and several approaches to these, are discussed.

Parsons, H. Mcilvaine

1988-01-01

93

Factors affecting growth factor activity in goat milk.  

PubMed

Growth factors that are present in goat milk may be responsible for its beneficial effects on the digestive system as described in ancient Chinese medical texts. To develop a nutraceutical product rich in growth factors for promoting gastrointestinal health, it is essential to collect milk with consistently high growth factor activity. Therefore, we investigated the factors affecting growth factor activity in goat milk. Among the 5 breeds of dairy goats tested, milk from Nubian goats had the highest growth factor activity. Tight-junction leakage induced by a 24-h milking interval did not increase growth factor activity in the milk. Milk collected from pregnant does had a significantly higher growth factor activity than milk collected postpartum. Growth factor activity decreased during the first 8 wk of lactation, fluctuated thereafter, and then increased dramatically after natural mating. During wk 1 to 8, growth factor activity was inversely correlated with milk yield and week of lactation. No correlation was observed during wk 9 to 29. After natural mating of the goats, the growth factor activity in the milk correlated significantly with somatic cell count and conductivity (a measure of membrane permeability), and correlated inversely with milk yield. Based on the above data, goat milk with higher growth factor activity could be selectively collected from Nubian pregnant does. PMID:16702258

Wu, F Y; Tsao, P H; Wang, D C; Lin, S; Wu, J S; Cheng, Y K

2006-06-01

94

Modifiable Risk Factors Branch (MRFB)  

Cancer.gov

The Modifiable Risk Factors Branch (MRFB) focuses on factors to reduce cancer risk in humans, including exposures to nutritional components; physical activity and energy balance; alcohol and tobacco; and infectious, physical, and chemical agents.

95

Environmental factors and aggressive behavior  

SciTech Connect

This paper briefly reviews some of the research areas which indicate a correlation between environmental factors and initiation of aggressive behavior. Environmental factors including lunar influences, month of birth, climate and the effects of crowding and certain chemicals are discussed.

Anderson, A.C.

1982-07-01

96

Viral Interferon Regulatory Factors  

PubMed Central

Upon viral infection, the major defensive strategy employed by the host immune system is the activation of the interferon (IFN)-mediated antiviral pathway, which is overseen by IFN regulatory factors (IRFs). In order to complete their life cycles, viruses must find a way to modulate the host IFN-mediated immune response. Kaposi's sarcoma-associated herpesvirus (KSHV), a human tumor-inducing herpesvirus, has developed a unique mechanism for antagonizing cellular IFN-mediated antiviral activity by incorporating viral homolog of the cellular IRFs, called vIRFs, into its genome. Here, we summarize the novel evasion mechanisms by which KSHV, through its vIRFs, circumvents IFN-mediated innate immune responses and deregulates the cell growth control mechanism. PMID:19715458

Kim, Myung Hee; Lee, Jong-Soo; Liang, Chengyu; Jung, Jae U.

2009-01-01

97

Unity power factor converter  

NASA Technical Reports Server (NTRS)

A unity power factor converter capable of effecting either inversion (dc-to-dc) or rectification (ac-to-dc), and capable of providing bilateral power control from a DC source (or load) through an AC transmission line to a DC load (or source) for power flow in either direction, is comprised of comparators for comparing the AC current i with an AC signal i.sub.ref (or its phase inversion) derived from the AC ports to generate control signals to operate a switch control circuit for high speed switching to shape the AC current waveform to a sine waveform, and synchronize it in phase and frequency with the AC voltage at the AC ports, by selectively switching the connections to a series inductor as required to increase or decrease the current i.

Wester, Gene W. (Inventor)

1980-01-01

98

Nucleon Electromagnetic Form Factors  

SciTech Connect

There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

2007-10-01

99

Helicopter Human Factors  

NASA Technical Reports Server (NTRS)

Even under optimal conditions, helicopter flight is a most demanding form of human-machine interaction, imposing continuous manual, visual, communications, and mental demands on pilots. It is made even more challenging by small margins for error created by the close proximity of terrain in NOE flight and missions flown at night and in low visibility. Although technology advances have satisfied some current and proposed requirements, hardware solutions alone are not sufficient to ensure acceptable system performance and pilot workload. However, human factors data needed to improve the design and use of helicopters lag behind advances in sensor, display, and control technology. Thus, it is difficult for designers to consider human capabilities and limitations when making design decisions. This results in costly accidents, design mistakes, unrealistic mission requirements, excessive training costs, and challenge human adaptability. NASA, in collaboration with DOD, industry, and academia, has initiated a program of research to develop scientific data bases and design principles to improve the pilot/vehicle interface, optimize training time and cost, and maintain pilot workload and system performance at an acceptable level. Work performed at Ames, and by other research laboratories, will be reviewed to summarize the most critical helicopter human factors problems and the results of research that has been performed to: (1) Quantify/model pilots use of visual cues for vehicle control; (2) Improve pilots' performance with helmet displays of thermal imagery and night vision goggles for situation awareness and vehicle control; (3) Model the processes by which pilots encode maps and compare them to the visual scene to develop perceptually and cognitively compatible electronic map formats; (4) Evaluate the use of spatially localized auditory displays for geographical orientation, target localization, radio frequency separation; (5) Develop and flight test control/display concepts; (6) Quantify, model, predict, and improve pilots, workload-management strategies; and (7) Design computer-game trainers to reduce training time and cost.

Hart, Sandra G.; Sridhar, Banavar (Technical Monitor)

1995-01-01

100

Quantification of Emission Factor Uncertainty  

EPA Science Inventory

Emissions factors are important for estimating and characterizing emissions from sources of air pollution. There is no quantitative indication of uncertainty for these emission factors, most factors do not have an adequate data set to compute uncertainty, and it is very difficult...

101

Phonological Awareness: Factors of Influence  

ERIC Educational Resources Information Center

Early child development is influenced by various genetic and environmental factors. This study aims to identify factors that affect the phonological awareness of preschool and first grade children. Based on a sample of 330 German-speaking children (mean age = 6.2 years) the following domains were evaluated: Parent factors, birth and pregnancy,…

Frohlich, Linda Paulina; Petermann, Franz; Metz, Dorothee

2013-01-01

102

Penalty Factors From Newton's Method  

Microsoft Academic Search

The penalty factors calculated by the classical B-coefficients method are shown to be proportional (but not equal) to the penalty factors calculated directly from the transposed acobian. It is also shown that the economic operating point is independent of the load and generation distribution factors Z. Expected computational times in examples with up to 5873 buses and 943 generators are

F. L. Alvarado

1978-01-01

103

FACTOR FINDER CD-ROM  

EPA Science Inventory

The Factor Finder CD-ROM is a user-friendly, searchable tool used to locate exposure factors and sociodemographic data for user-defined populations. Factor Finder improves the exposure assessors and risk assessors (etc.) ability to efficiently locate exposure-related informatio...

104

Factor Analysis via Components Analysis  

ERIC Educational Resources Information Center

When the factor analysis model holds, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits us to define new optimization criteria and estimation methods for exploratory factor analysis. Although this article is primarily conceptual in nature, an illustrative example and a small simulation show…

Bentler, Peter M.; de Leeuw, Jan

2011-01-01

105

Vector meson electromagnetic form factors  

E-print Network

The charge, magnetic and quadrupole form factors of vector mesons and the charge form factor of pseudo-scalar mesons are calculated in quenched lattice QCD. The charge radii and magnetic moments are derived. The quark sector contributions to the form factors are calculated separately and we highlight the environmental sensitivity of the light-quark contribution to charge radii.

B. G. Lasscock; J. Hedditch; D. B. Leinweber; A. G. Williams

2006-11-23

106

Sample size in factor analysis  

Microsoft Academic Search

In the factor analysis literature, much attention has be;;n given to the issue of sample size. It is widely understood that the use of larger samples in applica- tions of factor analysis tends to provide results such that sample factor loadings are more precise estimates of population loadings and are also more stable, or les s variable, across repeated sampling.

Robert C. MacCallum; Keith F. Widaman; Shaobo Zhang; Sehee Hong

1999-01-01

107

Características dinámicas de ensenadas estructurales de Chile central. Maitencillo- Cachagua y Papudo, Región de Valparaíso 1  

Microsoft Academic Search

The morphology of the coastline controlled by the tectonics and the morfoestructu- ra has formed the irregular coast, with two small headland bay beaches. The varia- bles that were analyzed - like relative position of the coast, refractive index, angle of curvature, type of beach dominated by waves and coastal forms - reflect the existence of two different coastal geographic

María Victoria; Soto Bäuerle; Joselyn Arriagada González

2007-01-01

108

[Environmental factors in ALS].  

PubMed

ALS is likely to be a disorder of multifactorial origin. Among all the factors that may increase the risk of ALS, environmental ones are being studied for many years, but in the recent years, several advances have pointed to a new interest in their potential involvement in the disease process, especially for the cyanotoxin BMAA. Food containing BMAA has been found on Guam, a well-known focus of ALS/parkinsonism/dementia and high levels of BMAA have been identified into the brain of these patients. The BMAA cyanotoxin is potentially ubiquitous and have also been found into the food of patients who died from ALS both in Europe and USA. BMAA can be wrongly integrated into the protein structure during mRNA traduction, competing with serine. This may induce abnormal protein folding and a subsequent cell death. Heavy metals, such as lead or mercury may be directly toxic for neuronal cells. Several works have suggested an increased risk of ALS in individuals chronically exposed to these metals. Exposure to pesticides has been suggested to be linked to an increased risk of developing ALS. The mechanism of their toxicity is likely to be mediated by paraoxonases. These proteins are in charge of detoxifying the organism from toxins, and particularly organophosphates. To date, there are insufficient scientific data to suggest that exposure to electromagnetic fields may increase the risk of having ALS. We are particularly missing longitudinal cohorts to demonstrate that risk. PMID:24703731

Juntas-Morales, Raul; Pageot, Nicolas; Corcia, Philippe; Camu, William

2014-05-01

109

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. By researching established training principles, examining future needs, and by using current practices in space flight training as test beds, both in Flight Controller and Crew Medical domains, this research project is mitigating program risks and generating templates and requirements to meet future training needs. Training efforts in Fiscal Year 09 (FY09) strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center (MCC) operations. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: 1) Risk associated with poor task design; 2) Risk of error due to inadequate information; and 3) Risk associated with reduced safety and efficiency due to poor human factors design.

Barshi, Immanuel; Byrne, Vicky; Arsintescu, Lucia; Connell, Erin

2010-01-01

110

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current Shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. Training efforts in FY07 strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center operations. Beginning in January 2008, the training research effort will include team training prototypes and tools. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: 1) Risk associated with poor task design; 2) Risk of error due to inadequate information; 3) Risk associated with reduced safety and efficiency due to poor human factors design.

Barshi, Immanuel; Byme, Vicky; Arsintescu, Lucia

2008-01-01

111

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. By researching established training principles, examining future needs, and by using current practices in space flight training as test beds, both in Flight Controller and Crew Medical domains, this research project is mitigating program risks and generating templates and requirements to meet future training needs. Training efforts in Fiscal Year 08 (FY08) strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center (MCC) operations. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: (1) Risk associated with poor task design (2) Risk of error due to inadequate information (3) Risk associated with reduced safety and efficiency due to poor human factors design

Barshi, Immanuel; Byrne, Vicky; Arsintescu, Lucia; Connell, Erin; Sandor, Aniko

2009-01-01

112

Statistical distribution of factors and factor images in factor analysis of medical image sequences  

NASA Astrophysics Data System (ADS)

From a time or energy image sequence, factor analysis of medical image sequences (FAMIS) estimates factors, representing kinetics or spectra in a given physiological compartment, and associated factor images, showing the compartments corresponding to each curve. In this paper, we show that the statistical properties of factor images and associated factors can be determined using a well known result from elementary probability theory. Numerical experiments are conducted to demonstrate that the variance observed in factor images can be predicted when the statistical properties of the original data are known. It is shown how these theoretical results can be used to relax the non-negativity constraints during FAMIS oblique analysis and to improve the quantitative interpretation of the factor images by associating a confidence interval with each pixel value.

Buvat, I.; Benali, H.; Di Paola, R.

1998-06-01

113

Fibroblast growth factor 23.  

PubMed

There is growing interest in the role of fibroblast growth factor 23 (FGF23) in various diseases of disordered mineral metabolism. In chronic kidney disease (CKD), where biochemical evidence of mineral disturbances is especially common, FGF23 measurement has been advocated as an early and sensitive marker for CKD-related bone disease. In this setting, FGF23 analysis may also improve the discrimination of risk of adverse renal and cardiovascular outcomes and aid targeting of those patients that are likely to benefit from interventions. Nonetheless, while the physiological relevance of FGF23 in the control of mineral metabolism is now firmly established, relatively little attention has been paid to important preanalytical and analytical aspects of FGF23 measurement that may impact on its clinical utility. Here we review these issues and discuss the suitability of FGF23 testing strategies for routine clinical practice. The current 'state-of-the-art' enzyme-linked immunosorbent assay methods for FGF23 measurement show poor agreement due to differences in FGF23 fragment detection, antibody specificity and calibration. Such analytical variability does not permit direct comparison of FGF23 measurements made with different assays and is likely to at least in part account for some of the inconsistencies noted between observational studies. From a clinical perspective, the lack of concordance has implications for the development of standardized reference intervals and clinical decision limits. Finally, the inherent assay-dependent biological variability of plasma FGF23 concentration can further complicate the interpretation of results and the design of FGF23-based testing protocols. Currently, it would be premature to consider incorporating FGF23 measurements into standard testing repertoires. PMID:24269946

Smith, Edward R; McMahon, Lawrence P; Holt, Stephen G

2014-03-01

114

Factoring polynomials with rational coefficients  

Microsoft Academic Search

In this paper we present a polynomial-time algorithm to solve the following problem: given a non-zero polynomial fe Q(X) in one variable with rational coefficients, find the decomposition of f into irreducible factors in Q(X). It is well known that this is equivalent to factoring primitive polynomials feZ(X) into irreducible factors in Z(X). Here we call f~ Z(X) primitive if

A. K. Lenstra; H. W. Lenstra; L. Lovfiasz

1982-01-01

115

Five Describing Factors of Dyslexia.  

PubMed

Two subtypes of dyslexia (phonological, visual) have been under debate in various studies. However, the number of symptoms of dyslexia described in the literature exceeds the number of subtypes, and underlying relations remain unclear. We investigated underlying cognitive features of dyslexia with exploratory and confirmatory factor analyses. A sample of 446 students (63 with dyslexia) completed a large test battery and a large questionnaire. Five factors were found in both the test battery and the questionnaire. These 10 factors loaded on 5 latent factors (spelling, phonology, short-term memory, rhyme/confusion, and whole-word processing/complexity), which explained 60% of total variance. Three analyses supported the validity of these factors. A confirmatory factor analysis fit with a solution of five factors (RMSEA = .03). Those with dyslexia differed from those without dyslexia on all factors. A combination of five factors provided reliable predictions of dyslexia and nondyslexia (accuracy >90%). We also looked for factorial deficits on an individual level to construct subtypes of dyslexia, but found varying profiles. We concluded that a multiple cognitive deficit model of dyslexia is supported, whereas the existence of subtypes remains unclear. We discussed the results in relation to advanced compensation strategies of students, measures of intelligence, and various correlations within groups of those with and without dyslexia. PMID:25398549

Tamboer, Peter; Vorst, Harrie C M; Oort, Frans J

2014-11-14

116

Heavy quark impact factor in k T -factorization  

NASA Astrophysics Data System (ADS)

We present the calculation of the finite part of the heavy quark impact factor at next-to-leading logarithmic accuracy in a form suitable for phenomenological studies such as the calculation of the cross-section for single bottom quark production at the LHC within the k T -factorization scheme.

Chachamis, Grigorios; Deak, Michal; Rodrigo, Germán

2013-12-01

117

Protective Factors and Risk Factors in Preschool Aged Children  

Microsoft Academic Search

Do resiliency or protective factors moderate risk factors in preschool aged children? This study looks at pre- and post-treatment data from 49 preschool children whose average age was 4 years old. The treatment included prevention and early intervention programs that promote emotional well-being and the development of healthy interpersonal relationships in children, ages birth to eight, and their caregivers. The

Monica R. Geist; P. Antonio; Olmos Gallo; Mary Grimmer; Daniel J. Mundfrom

2006-01-01

118

Reliability and Validity: One Factor and Third Factor Tests  

E-print Network

Sept 2003 Html links are live Reliability and validity are crucial issues in research. ReliabilityChapter 7 Reliability and Validity: One Factor and Third Factor Tests D. White and A. Korotayev 26 may have high validity but low reliability, in which case its correlations with other high validity

White, Douglas R.

119

Factors affecting sorghum protein digestibility  

Microsoft Academic Search

In the semi-arid tropics worldwide, sorghum (Sorghum bicolor (L.) Moench) is cultivated by farmers on a subsistence level and consumed as food by humans. A nutritional limitation to its use is the poor digestibility of sorghum protein when wet cooked. The factors affecting wet cooked sorghum protein digestibility may be categorised into two main groups: exogenous factors (grain organisational structure,

K. G Duodu; J. R. N Taylor; P. S Belton; B. R Hamaker

2003-01-01

120

The kaon electromagnetic form factor  

E-print Network

We use recent data on K^+ -> pi^+ e^+ e^-, together with known values for the pion form factor, to derive experimental values for the kaon electromagnetic form factor for 0 < q^2 < 0.125 (GeV/c)^2. The results are then compared with the predictions of the Vector Meson Dominance model, which gives a good fit to the experimental results.

J. Lowe; M. D. Scadron

2005-09-28

121

PEDF: a multifaceted neurotrophic factor  

Microsoft Academic Search

Pigment epithelium-derived factor (PEDF) is a potent and broadly acting neurotrophic factor that protects neurons in many regions of the central nervous system against insults such as glutamate excitotoxicity and oxidative damage. Since the crystal structure of PEDF was solved, its biological actions have begun to be mapped to specific structural domains. Here we discuss the structure and function of

Joyce Tombran-Tink; Colin J. Barnstable

2003-01-01

122

Journal Information Journal Impact Factor  

E-print Network

Journal Information Journal Impact Factor 5-Year Journal Impact Factor Journal Self Cites Journal Immediacy Index 2012 JCR Science Edition Journal: Applications of Mathematics Mark Journal Title ISSN Total- life APPL MATH-CZECH 0862-7940 240 0.222 0.549 0.054 37 7.3 >10.0 Cited Journal Citing Journal Source

KrejcĂ­, Pavel

123

Cardiovascular risk factors among Chamorros  

Microsoft Academic Search

BACKGROUND: Little is known regarding the cardiovascular disease risk factors among Chamorros residing in the United States. METHODS: The Chamorro Directory International and the CDC's Behavioral Risk Factor Surveillance System Questionnaire (BRFSS) were used to assess the health related practices and needs of a random sample of 228 Chamorros. RESULTS: Inactivity, hypertension, elevated cholesterol and diabetes mellitus were more prevalent

Binh Chiem; Victoria Nguyen; Phillis L Wu; Celine M Ko; Lee Ann Cruz; Georgia Robins Sadler

2006-01-01

124

Smoking – A Renal Risk Factor  

Microsoft Academic Search

One of the most important tasks of clinical and experimental nephrology is to identify the risk factors of progression of renal failure. A major renal risk factor which has not been sufficiently acknowledged despite increasing evidence is cigarette smoking. Diabetologists were the first to recognize the adverse effects of smoking on the kidney: both in type 1 and in type

Stephan R. Orth

2000-01-01

125

Factorization with genus 2 curves  

NASA Astrophysics Data System (ADS)

The elliptic curve method (ECM) is one of the best factorization methods available. It is possible to use hyperelliptic curves instead of elliptic curves but it is in theory slower. We use special hyperelliptic curves and Kummer surfaces to reduce the complexity of the algorithm. Our implementation GMP-HECM is faster than GMP-ECM for factoring large numbers.

Cosset, Romain

2010-04-01

126

Factors Affecting Survival and Satisfaction  

Microsoft Academic Search

This article consists of four parts. First, the authors review the literature on factors that affect job satisfaction and longevity among various professional groups. Second, they report the results of a pilot survey of 27 master's level oncology social workers in Michigan designed to explore the perceived impact of variables identified in the literature-personal history, patient-related factors, organizational dynamics, social

Linda Supple-Diaz; Debbie Mattison

1992-01-01

127

Activity Factors of the Korean Exposure Factors Handbook  

PubMed Central

Exposure factors based on the Korean population are required for making appropriate risk assessment. It is expected that handbooks for exposure factors will be applied in many fields, as well as by health department risk assessors. The present article describes the development of an exposure factors handbook that specifically focuses on human activities in situations involving the possible risk of exposure to environmental contaminants. We define majour exposure factors that represent behavioral patterns for risk assessment, including time spent on routine activities, in different places, on using transportation, and engaged in activities related to water contact including swimming, bathing and washing. Duration of residence and employment are also defined. National survey data were used to identify recommended levels of exposure factors in terms of time spent on routine activities and period of residence and employment. An online survey was conducted with 2073 subjects who were selected using a stratified random sampling method in order to develop a list of exposure factors for the time spent in different places and in performing water-related activities. We provide the statistical distribution of the variables, and report reference levels of average exposure based on the reliable data in our exposure factors handbook. PMID:24570804

Jo, Soo-Nam; Kim, So-Yeon; Lee, Kyung-Eun; Choi, Kyung-Ho; Kim, Young-Hee

2014-01-01

128

24 CFR 598.305 - Designation factors.  

Code of Federal Regulations, 2011 CFR

...2010-04-01 true Designation factors. 598.305 Section 598...EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Designation Process § 598.305 Designation factors. In choosing among nominated...b)); and (c) Other factors. Other factors...

2011-04-01

129

24 CFR 598.305 - Designation factors.  

Code of Federal Regulations, 2010 CFR

...2010-04-01 false Designation factors. 598.305 Section 598...EMPOWERMENT ZONES: ROUND TWO AND THREE DESIGNATIONS Designation Process § 598.305 Designation factors. In choosing among nominated...b)); and (c) Other factors. Other factors...

2010-04-01

130

The Infinite Hierarchical Factor Regression Model  

Microsoft Academic Search

We propose a nonparametric Bayesian factor regression model that accounts for uncertainty in the number of factors, and the relationship b etween factors. To accomplish this, we propose a sparse variant of the Indian Buffet Process and couple this with a hierarchical model over factors, based on Kingman's coalescent. We apply this model to two problems (factor analysis and factor

Piyush Rai; Hal Daumé III

2008-01-01

131

Using Bayes factors for multi-factor, biometric authentication  

NASA Astrophysics Data System (ADS)

Multi-factor/multi-modal authentication systems are becoming the de facto industry standard. Traditional methods typically use rates that are point estimates and lack a good measure of uncertainty. Additionally, multiple factors are typically fused together in an ad hoc manner. To be consistent, as well as to establish and make proper use of uncertainties, we use a Bayesian method that will update our estimates and uncertainties as new information presents itself. Our algorithm compares competing classes (such as genuine vs. imposter) using Bayes Factors (BF). The importance of this approach is that we not only accept or reject one model (class), but compare it to others to make a decision. We show using a Receiver Operating Characteristic (ROC) curve that using BF for determining class will always perform at least as well as the traditional combining of factors, such as a voting algorithm. As the uncertainty decreases, the BF result continues to exceed the traditional methods result.

Giffin, A.; Skufca, J. D.; Lao, P. A.

2015-01-01

132

Factorization in exclusive quarkonium production  

SciTech Connect

We present factorization theorems for two exclusive heavy-quarkonium production processes: production of two quarkonia in e{sup +}e{sup -} annihilation and production of a quarkonium and a light meson in B-meson decays. We describe the general proofs of factorization and supplement them with explicit one-loop analyses, which illustrate some of the features of the soft-gluon cancellations. We find that violations of factorization are generally suppressed relative to the factorized contributions by a factor v{sup 2}m{sub c}/Q for each S-wave charmonium and a factor m{sub c}/Q for each L-wave charmonium with L>0. Here, v is the velocity of the heavy quark or antiquark in the quarkonium rest frame, Q={radical}(s) for e{sup +}e{sup -} annihilation, Q=m{sub B} for B-meson decays, {radical}(s) is the e{sup +}e{sup -} center-of-momentum energy, m{sub c} is the charm-quark mass, and m{sub B} is the B-meson mass. There are modifications to the suppression factors if quantum-number restrictions apply for the specific process.

Bodwin, Geoffrey T.; Garcia i Tormo, Xavier; Lee, Jungil [High Energy Physics Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439 (United States); High Energy Physics Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA and Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2G7 (Canada); Department of Physics, Korea University, Seoul 136-701 (Korea, Republic of)

2010-06-01

133

Environmental risk factors for autism.  

PubMed

Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among the increasingly seen examples in which there is a fetal basis for later disease or disorder. Environmental, genetic, and epigenetic factors all play a role in determining the risk of autism and some of these effects appear to be transgenerational. Identification of the most critical windows of developmental vulnerability is paramount to understanding when and under what circumstances a child is at elevated risk for autism. No single environmental factor explains the increased prevalence of autism. While a handful of environmental risk factors have been suggested based on data from human studies and animal research, it is clear that many more, and perhaps the most significant risk factors, remain to be identified. The most promising risk factors identified to date fall within the categories of drugs, environmental chemicals, infectious agents, dietary factors, and other physical/psychological stressors. However, the rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition. For the way forward, it seems clear that additional focused research is needed. But more importantly, successful risk reduction strategies for autism will require more extensive and relevant developmental safety testing of drugs and chemicals. PMID:24149029

Dietert, Rodney R; Dietert, Janice M; Dewitt, Jamie C

2011-01-01

134

What Factors Impact a Greenhouse?  

NSDL National Science Digital Library

This activity has students use a model to investigate factors in greenhouse heating and cooling. The type of surface that sunlight first encounters is the most important factor. Forests, grasslands, ocean surfaces, ice caps, deserts, and cities all absorb, reflect, and radiate radiation differently. As a result of this activity students will be able to identify at least three factors affecting the heat-trapping ability of a greenhouse, explain the factors important in the atmosphere's heat trapping ability, and understand the influence of albedo on earth's temperature. The student guide has an overall description of the activity, a list of materials, the procedure, and observations and questions. The instructor guide contains detailed background material, learning goals, alignment to national standards, grade level/time, details on materials and preparation, procedure, assessment ideas, and modifications for alternative learners.

135

Environmental Factors Inducing Human Cancers  

PubMed Central

Background An explosion of research has been done in discovering how human health is affected by environmental factors. I will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. Some risk factors may not cause cancer. Other factors initiate consecutive genetic mutations that would eventually alter the normal pathway of cellular proliferations and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes and DNA repairing genes) play a vital role in altering the normal cell division. In recent years, molecular genetics have greatly increased our understanding of the basic mechanisms in cancer development and utilizing these molecular techniques for cancer screening, diagnosis, prognosis and therapies. Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens. PMID:23304670

Parsa, N

2012-01-01

136

Factors Affecting Option Premium Values  

E-print Network

Factors Affecting Option Premium Values Jason Johnson, Jackie Smith, Kevin Dhuyvetter and Mark Waller* Put Options Hedging in the futures market with options is much like buying an insurance policy to protect commodity sellers against declining...

Johnson, Jason; Smith, Jackie; Dhuyvetter, Kevin C.; Waller, Mark L.

1999-06-23

137

Formulas for Image Factor Scores  

ERIC Educational Resources Information Center

Formulas are presented in this paper for computing scores associated with factors of G, the image covariance matrix, under three conditions. The subject of the paper is restricted to "pure" image analysis. (Author/NE)

Hakstian, A. Ralph

1973-01-01

138

Radiant-interchange Configuration Factors  

NASA Technical Reports Server (NTRS)

A study is presented of the geometric configuration factors required for computing radiant heat transfer between opaque surfaces separated by a nonabsorbing medium and various methods of determining the configuration factors are discussed. Configuration-factor solutions available in the literature have been checked and the more complicated equations are presented as families of curves. Cases for point, line, and finite-area sources are worked out over a wide range of geometric proportions. These cases include several new configurations involving rectangles, triangles, and cylinders of finite length which are integrated and tabulated. An analysis is presented, in which configuration factors are employed of the radiant heat transfer to the rotor blades of a typical gas turbine under different conditions of temperature and pressure. (author)

Hamilton, D C :; Morgan, W R

1952-01-01

139

Epo and other hematopoietic factors  

PubMed Central

The growth factors erythropoietin and granulocyte-colony stimulating factor have hematopoietic and non-hematopoietic functions. Both are used clinically in their recombinant forms. Both also have interesting tissue-protective effects in other organs, which are unrelated to their hematopoietic functions. They have clinical hematopoietic uses in neonatal populations and in experimental non-hematopoietic research, and clinical potential as neuroprotective or tissue-protective agents. PMID:17321813

Juul, Sandra; Felderhoff-Mueser, Ursula

2007-01-01

140

Baryon Form Factors at Besiii  

NASA Astrophysics Data System (ADS)

The electric and magnetic form factors are defined as basic observables which reflect the composite nature of the nucleon. They have long been studied in electron scattering, and now we are here to discuss opportunities that can come from an e+e- collider (in the time-like region) at moderate energies where exclusive cross sections can be measured. With largest data samples and better resolutions, we discuss the status of baryon form factors and a bright opportunity of measurement at BESIII.

Wang, Yadi

2014-12-01

141

Neighborhood Risk Factors for Obesity  

Microsoft Academic Search

Objective: The goal of this study was to explore neighborhood environmental factors associated with obesity in a sample of adults living in a major U.S. metropolitan area.Research Methods and Procedures: This was a multi-level study combining data from the U.S. Behavioral Risk Factor Surveillance System with data from the U.S. Census. A total of 15,358 subjects living in 327 zip

Russ P. Lopez

2007-01-01

142

Interstitial fibrosis and growth factors.  

PubMed Central

Interstitial pulmonary fibrosis (IPF) is scarring of the lung caused by a variety of inhaled agents including mineral particles, organic dusts, and oxidant gases. The disease afflicts millions of individuals worldwide, and there are no effective therapeutic approaches. A major reason for this lack of useful treatments is that few of the molecular mechanisms of disease have been defined sufficiently to design appropriate targets for therapy. Our laboratory has focused on the molecular mechanisms through which three selected peptide growth factors could play a role in the development of IPF. Hundreds of growth factors and cytokines could be involved in the complex disease process. We are studying platelet-derived growth factor because it is the most potent mesenchymal cell mitogen yet described, transforming growth factor beta because it is a powerful inducer of extracellular matrix (scar tissue) components by mesenchymal cells, and tumor necrosis factor alpha because it is a pleiotropic cytokine that we and others have shown is essential for the development of IPF in animal models. This review describes some of the evidence from studies in humans, in animal models, and in vitro, that supports the growth factor hypothesis. The use of modern molecular and transgenic technologies could elucidate those targets that will allow effective therapeutic approaches. Images Figure 1 Figure 2 PMID:10931794

Lasky, J A; Brody, A R

2000-01-01

143

Industrial Power Factor Analysis Guidebook.  

SciTech Connect

Power factor is a way of measuring the percentage of reactive power in an electrical system. Reactive power represents wasted energy--electricity that does no useful work because the electrical current is out of phase with the voltage. Reactive power is used by inductive loads (such as, motors, transformers, fluorescent lights, arc welders and induction furnaces) to sustain their magnetic fields. Electric systems with many motors exhibit low power factors, increased conductor and transformer losses, and lower voltages. Utilities must supply both active and reactive power and compensate for these losses. Power factor can be improved by the addition of shunt capacitors. Capacitors act in opposition to inductive loads, thereby minimizing the reactive power required to serve them. In raising the power factor, shunt capacitors release energy to the system, reduce system losses, and ultimately decrease power costs. Improving system power factor can reduce reactive and active power losses for both industry and utilities through the addition of shunt capacitors. This Guide Book gives electric utility technical staff, industrial end-users, consultants and BPA employees a step-by-step method for evaluating the cost effectiveness of installing power factor correction capacitors in an industrial plant.

Electrotek Concepts.

1995-03-01

144

Sparse Bayesian infinite factor models  

PubMed Central

We focus on sparse modelling of high-dimensional covariance matrices using Bayesian latent factor models. We propose a multiplicative gamma process shrinkage prior on the factor loadings which allows introduction of infinitely many factors, with the loadings increasingly shrunk towards zero as the column index increases. We use our prior on a parameter-expanded loading matrix to avoid the order dependence typical in factor analysis models and develop an efficient Gibbs sampler that scales well as data dimensionality increases. The gain in efficiency is achieved by the joint conjugacy property of the proposed prior, which allows block updating of the loadings matrix. We propose an adaptive Gibbs sampler for automatically truncating the infinite loading matrix through selection of the number of important factors. Theoretical results are provided on the support of the prior and truncation approximation bounds. A fast algorithm is proposed to produce approximate Bayes estimates. Latent factor regression methods are developed for prediction and variable selection in applications with high-dimensional correlated predictors. Operating characteristics are assessed through simulation studies, and the approach is applied to predict survival times from gene expression data. PMID:23049129

Bhattacharya, A.; Dunson, D. B.

2011-01-01

145

Erikson Psychosocial Stage Inventory: A Factor Analysis  

Microsoft Academic Search

The 72-item Erikson Psychosocial Inventory (EPSI) was factor analyzed for a group of 534 university freshmen and sophomore students. Seven factors including 54 items emerged which the authors labeled Initiative, Industry, Identity, Friendship, Dating, Goal Clarity and Self-Confidence. Items representing Erikson's first two factors, Trust and Autonomy, were dispersed across the new set of factors; this factor pattern was discussed

Mary McPhail Gray; Jean M. Ispa; Kathy R. Thornburg

1986-01-01

146

Factors influencing healthcare service quality  

PubMed Central

Background: The main purpose of this study was to identify factors that influence healthcare quality in the Iranian context. Methods: Exploratory in-depth individual and focus group interviews were conducted with 222 healthcare stakeholders including healthcare providers, managers, policy-makers, and payers to identify factors affecting the quality of healthcare services provided in Iranian healthcare organisations. Results: Quality in healthcare is a production of cooperation between the patient and the healthcare provider in a supportive environment. Personal factors of the provider and the patient, and factors pertaining to the healthcare organisation, healthcare system, and the broader environment affect healthcare service quality. Healthcare quality can be improved by supportive visionary leadership, proper planning, education and training, availability of resources, effective management of resources, employees and processes, and collaboration and cooperation among providers. Conclusion: This article contributes to healthcare theory and practice by developing a conceptual framework that provides policy-makers and managers a practical understanding of factors that affect healthcare service quality. PMID:25114946

Mosadeghrad, Ali Mohammad

2014-01-01

147

Environmental risk factors for osteoporosis  

SciTech Connect

Environmental risk factors for osteoporosis were reviewed at a conference held at the National Institute for Environmental Health Sciences 8-9 November 1993. The conference was co-sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease and the NIH Office of Research in Women's Health. The objective of the conference was to review what is known about risk factors for osteoporosis and to identify gaps in the present state of knowledge that might be addressed by future research. The conference was divided into two broad themes. The first session focused on current knowledge regarding etiology, risk factors, and approaches to clinical and laboratory diagnosis. This was followed by three sessions in which various environmental pollutants were discussed. Topics selected for review included environmental agents that interfere with bone and calcium metabolism, such as the toxic metals lead, cadmium, aluminum, and fluoride, natural and antiestrogens, calcium, and vitamin D.

Goyer, R.A.; Korach, K.S. (National Institute of Environmental Health Sciences, Triangle Park, NC (United States)); Epstein, S. (Albert Einstein Medical Center, Philadelphia, PA (United States)); Bhattacharyya, M. (Argonne National Lab., IL (United States)); Pounds, J. (Wayne State Univ., Detroit, MI (United States))

1994-04-01

148

[Heliogeophysical factors and aviation accidents].  

PubMed

It was shown by two independent methods that there is a certain correlation between the number of aviation accidents and heliogeophysical factors. The statistical and spectral analyses of time series of heliogeomagnetic factors and the number of aviation accidents in 1989-1995 showed that, of 216 accidents, 58% are related to sudden geomagnetic storms. A similar relation was revealed for aviation catastrophes (64% out of 86 accidents) and emergencies (54% out of 130 accidents) that coincided in time with heliogeomagnetic storms. General periodicities of the series were revealed by the method of spectral analysis, namely, cycles of 30, 42, 46, 64, 74, 83, 99, 115, 143, 169, 339 days, which confirms the causative relation between the number of aviation accidents and heliogeomagnetic factors. It is assumed that some aviation accidents that coincided in time with geomagnetic storms, are due to changes in professional abilities of pilots that were in the zone of storms. PMID:9783079

Komarov, F I; Oraevski?, V N; Sizov, Iu P; Tsirul'nik, L B; Kanonidi, Kh D; Ushakov, I B; Shalimov, P M; Kimlyk, M V; Glukhov, D V

1998-01-01

149

General Factors of the Korean Exposure Factors Handbook  

PubMed Central

Risk assessment considers the situations and characteristics of the exposure environment and host. Various physiological variables of the human body reflects the characteristics of the population that can directly influence risk exposure. Therefore, identification of exposure factors based on the Korean population is required for appropriate risk assessment. It is expected that a handbook about general exposure factors will be used by professionals in many fields as well as the risk assessors of the health department. The process of developing the exposure factors handbook for the Korean population will be introduced in this article, with a specific focus on the general exposure factors including life expectancy, body weight, surface area, inhalation rates, amount of water intake, and soil ingestion targeting the Korean population. The researchers used national databases including the Life Table and the 2005 Time Use Survey from the National Statistical Office. The anthropometric study of size in Korea used the resources provided by the Korean Agency for Technology and Standards. In addition, direct measurement and questionnaire surveys of representative samples were performed to calculate the inhalation rate, drinking water intake, and soil ingestion. PMID:24570802

Kim, So-Yeon; Kim, Sun-Ja; Lee, Kyung-Eun; Cheong, Hae-Kwan; Kim, Eun-Hye; Choi, Kyung-Ho; Kim, Young-Hee

2014-01-01

150

Making a tooth: growth factors, transcription factors, and stem cells  

Microsoft Academic Search

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-mesenchymal interactions. These processes involve a series of inductive and permissive interactions that result in the determination, differentiation, and organization of odontogenic tissues. Multiple signaling molecules, including BMPs, FGFs, Shh, and Wnt proteins, have been implicated in mediating these tissue interactions. Transcription factors participate in epithelial-mesenchymal interactions via linking the

Yan Ding ZHANG; Zhi CHEN; Yi Qiang SONG; Chao LIU; Yi Ping CHEN

2005-01-01

151

[Coagulation factor mutations and thrombosis].  

PubMed

The coagulation system is governed by a subtle balance between clotting activators and inhibitors. Many genes can contribute to the overall phenotype, and polymorphisms may act to up regulate or down regulate the generation of thrombin, the coagulation-key enzyme. An increase in coagulation factor (gain function) or/and a decrease in coagulation inhibitors (loss of function) may favor venous thromboembolism (VTE). It has been observed since a long time that VTE may be a familial disease, but it was only in 1965 that Egeberg published the first case of inherited antithrombin (AT) deficiency. This was followed by similar reports of protein C (PC) and protein S (PS) deficiencies. Hereditary thrombophilia was thus initially considered as a rare monogenic disorder with incomplete penetrance. AT, PC and PS deficiencies are due to multiple and mostly private mutations of the corresponding genes. Most patients are heterozygous and experience VTE at adult age. Homozygosity associated with severe thrombosis at birth has been observed in newborns with undetectable PC or PS concentrations. The discovery of factor (F) V Leiden and F2 g.20210 G>A, two gain of function mutations, challenged the view of thrombophilia as a rare monogenic disorder. FV Leiden and F2 g.20210 G>A are due to a founder effect and affect populations of European descent with frequencies at 5% and 3% respectively. These two mutations are moderate of risk factor for thrombosis and paved the way for gene-gene and gene-environment interactions. Patients carrying more than one genetic risk factor are at higher risk to develop VTE. The exposition to acquired risk factors such as estrogen based oral contraception may also have a synergistic effect favoring thrombosis in patients with FV Leiden or other genetic risk factors. PMID:17101102

Aiach, Martine; Alhenc-Gelas, Martine; Borgel, Delphine; Emmerich, Joseph; Gandrille, Sophie; Picard, Véronique

2006-11-01

152

Growth factors in subglottic stenosis.  

PubMed

We sought to define the role of fibrogenic peptides in subglottic stenosis (SGS). Biopsy specimens were obtained from patients with stenosis following endotracheal intubation (group 1, n = 5, mean age 5), patients without a history of any precedent trauma, ie. idiopathic stenosis (group 2, n = 3, mean age 40), and those without stenosis (group 3, n = 3, mean age 70). Formalin-fixed biopsy specimens were analyzed following immunohistochemical staining to determine if epidermal growth factor (EGF), platelet-derived growth factor-AA and -BB (PDGF-AA/BB), transforming growth factor-beta 1 and -beta 2 (TGF-beta 1, beta 2), or basic fibroblast growth factor (bFGF) was deposited in these tissues. Blinded analysis revealed TGF-beta 2 and PDGF-AA to be present in seven of eight biopsy specimens from SGS and absent in controls. Staining for PDGF-BB was observed in the mucosa and submucosa and occasionally within vessel walls. Staining of individual growth factors appeared to correlate closely with the presence of granulation tissue. Essentially no bFGF or TGF-beta 1 was observed. Differences were found between patients in groups 1 and 2; tissue from group 1 revealed deposition of EGF and PDGF-BB in submucosa, epithelium, and vasculature. In summary, our experimental findings implicate PDGF and TGF-beta 2, perhaps acting in concert, in mediating the pathologic fibrotic process observed in subglottic stenosis. Epidermal growth factor, in conjunction with TGF-beta and PDGF, may also have a role, but further investigation is needed to more precisely define it. PMID:8973279

Scioscia, K A; Miller, F; April, M M; Gruber, B L

1996-12-01

153

Bayes factors and multimodel inference  

USGS Publications Warehouse

Multimodel inference has two main themes: model selection, and model averaging. Model averaging is a means of making inference conditional on a model set, rather than on a selected model, allowing formal recognition of the uncertainty associated with model choice. The Bayesian paradigm provides a natural framework for model averaging, and provides a context for evaluation of the commonly used AIC weights. We review Bayesian multimodel inference, noting the importance of Bayes factors. Noting the sensitivity of Bayes factors to the choice of priors on parameters, we define and propose nonpreferential priors as offering a reasonable standard for objective multimodel inference.

Link, W.A.; Barker, R.J.

2009-01-01

154

Pseudoscalar meson transition form factors  

NASA Astrophysics Data System (ADS)

The existing data on pseudoscalar meson transition form factors are described by the sophisticated Unitary & Analytic model and are well elaborated for pseudoscalar mesons and 1/2+ octet baryons. Knowing the transition form factors, ?(e+e-?P?) are specified and the contributions of e+e-?P? processes to the muon g-2 anomaly are evaluated with remarkably suppressed errors. Also the two-gamma decay widths of the ?0, ? and ?? pseudoscalar mesons are determined by an alternative method and compared with values given by the newest Review of Particle Physics.

Dubnicka, S.; Dubnickova, A. Z.; Liptaj, A.

2012-04-01

155

Six and Seven as Factors  

NSDL National Science Digital Library

This 2-lesson unit offers a variety of activities and games to help students master multiplication facts with 6 and 7 as factors. It is intended for students who understand the process of multiplication and have mastered the facts where 0, 1, 2, 3, 4, and 5 are factors. Students make use of the effects and properties of multiplication, write and solve story problems, and develop materials and strategies to assist in becoming fluent with the facts. The unit includes questions for students and teachers, a printable multiplication chart, extension ideas, and link to a Virtual Spinner and an online Times Table applet (both catalogued separately).

Grace M. Burton

2012-01-01

156

Environmental factors associated with asthma.  

PubMed Central

Asthma, a disease of attacks and remission, continues to account for substantial morbidity and direct economic costs. Numerous studies--epidemiologic, toxicologic and clinical--present evidence for a broad spectrum of environmental risk factors associated with asthma. This review summarizes current thinking on a subset of these factors. Knowledge of potential environmental determinants of asthma is important to both the patient and healthcare professional in the application of multiple modalities of medical and environmental intervention for management of the development, and exacerbation of this chronic inflammatory disorder of the airways. PMID:12760611

Walker, Bailus; Stokes, Lynette D.; Warren, Rueben

2003-01-01

157

Growth factors in orthopedic surgery.  

PubMed

Growth factors have represented an essential issue of interest for the researchers and clinicians in orthopedics and trauma over the last 40 years. In the last 10 to 15 years, the advances registered in this field have permitted the identification of the most active cellular and humoral factors as well as the improvement of their use in the orthopedic and trauma surgery. Their domain of application has been continuously enlarged and the results have been visible from the beginning. The authors present their appreciation on the actual state of this subject as well as their experience with results and related conclusions. PMID:20302195

Zaharia, Comeliu; Niculescu, Marius; Despa, Nicoleta; Simionescu, Maya; Jinga, Victor; Fleseriu, Irina

2010-01-01

158

Lymphangiogenic factors, mechanisms, and applications  

PubMed Central

Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment. PMID:24590272

Zheng, Wei; Aspelund, Aleksanteri; Alitalo, Kari

2014-01-01

159

Factor Structure of the Rational Behavior Inventory.  

ERIC Educational Resources Information Center

Administered the Rational Behavior Inventory (RBI) to 510 undergraduates and performed factor analytic procedures. Comparison with the original factors showed nine of the original 11 factor patterns were approximated reasonably. (JAC)

Himle, David P.; And Others

1985-01-01

160

What Are Coronary Heart Disease Risk Factors?  

MedlinePLUS

... from the NHLBI on Twitter. What Are Coronary Heart Disease Risk Factors? Coronary heart disease risk factors are ... Grand Opportunity" Exome Sequencing Project 10/14/2014 Heart Disease Risk Factors 10/14/2014 All of Our ...

161

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2010 CFR

...life. Thus, if the factor is less than zero, use zero. Additive deterioration factors must be specified to one more decimal place than the applicable standard...life. Thus, if the factor is less than one, use one. A multiplicative...

2010-07-01

162

Form Factors and Vector Mesons  

Microsoft Academic Search

The 2pi and 3pi resonances are re-examined from the point of view that they are vector mesons coupled to conserved currents. The theory of unstable mesons is discussed and formulas are then derived for the emission and propagation of these mesons. The connection with electromagnetic form factors is then given, particularly for the simple case of infinite bare mass. The

Murray Gell-Mann; Fredrik Zachariasen

1961-01-01

163

Neurotrophic factor for central neurons.  

PubMed

A serum-free culture of dissociated neurons from embryonic rat hippocampus has been established as a rapid and quantitative in vitro test system for neurotrophic signals in the mammalian brain. By means of this cell culture bioassay, a novel low molecular weight neurotrophic factor (NTF) could be identified. NTF is essential for in vitro brain neuron development, promoting survival and neurite outgrowth. The diffusible factor is synthesized and secreted into serum-free defined medium by cultured astrocytes from rat cerebral hemispheres. The number of viable neurons responding to NTF by neurite outgrowth is dependent on the concentration of the factor. Fractionation of astroglial conditioned medium by gel filtration on columns of Sephadex G-10 recovered biological activity of NTF in a single sharp peak corresponding to an apparent molecular weight of approximately equal to 500. NTF is stable to heat and cold and resistant to trypsin and pronase. Unlike nerve growth factor, NTF has no apparent effect on the neurite outgrowth of peripheral neurons. NTF-like activity is present in situ in the mammalian brain, in certain other nonneural tissues, and in C6 and B12 glioma cell conditioned media. PMID:6366800

Müller, H W; Beckh, S; Seifert, W

1984-02-01

164

Factors Affecting Willingness to Mentor  

ERIC Educational Resources Information Center

The paper presents a survey among 300 employees in Northern Italy to assess the willingness to mentor and identify the factors that affect it. Men and respondents with previous mentoring experience indicate a higher willingness to be a mentor. Willingness is affected by personal characteristics that are perceived as necessary for a mentor and the…

Ghislieri, Chiara; Gatti, Paola; Quaglino, Gian Piero

2009-01-01

165

Highly parallel sparse Cholesky factorization  

NASA Technical Reports Server (NTRS)

Several fine grained parallel algorithms were developed and compared to compute the Cholesky factorization of a sparse matrix. The experimental implementations are on the Connection Machine, a distributed memory SIMD machine whose programming model conceptually supplies one processor per data element. In contrast to special purpose algorithms in which the matrix structure conforms to the connection structure of the machine, the focus is on matrices with arbitrary sparsity structure. The most promising algorithm is one whose inner loop performs several dense factorizations simultaneously on a 2-D grid of processors. Virtually any massively parallel dense factorization algorithm can be used as the key subroutine. The sparse code attains execution rates comparable to those of the dense subroutine. Although at present architectural limitations prevent the dense factorization from realizing its potential efficiency, it is concluded that a regular data parallel architecture can be used efficiently to solve arbitrarily structured sparse problems. A performance model is also presented and it is used to analyze the algorithms.

Gilbert, John R.; Schreiber, Robert

1990-01-01

166

Factors Affecting Illegal Hacking Behavior  

Microsoft Academic Search

The damage caused by illegal hacking has become one of the serious problems facing society. Based on general deterrence theory, social bond theory and social learning theory, the paper proposes a model which examines the factors affecting the likelihood an individual will engage in illegal hacking behavior. Data was gathered from a survey of 127 individuals who attended a hacker’s

Randall Young; Lingling Zhang

2005-01-01

167

Critical factors to bioenergy implementation  

Microsoft Academic Search

Barriers to bioenergy technology implementation have received increased attention in recent years. This paper contributes to the identification and analysis of barriers and drivers behind bioenergy market growth, here labelled “critical factors”. It presents a framework for the analysis of both existing and projected bioenergy market potential, using economic concepts and models from transaction cost theory and industrial organization. The

Anders Roos; Robin L. Graham; Bo Hektor; Christian Rakos

1999-01-01

168

Solving Quadratic Equations by Factoring  

NSDL National Science Digital Library

This video explains how to solve quadratic equations with the factoring method. In 4 minutes 23 seconds, the two narrators explain in detail the steps required. Additionally, how these equations relate to objects and events in the real world such as roller coasters is covered.

2012-08-06

169

Personality Factors and Instructional Methods  

ERIC Educational Resources Information Center

The Children's Personality Questionnaire (CPQ) was administered to 23 academically handicapped children (mean IQ, 79) and 35 academically gifted students (mean IQ, 147). The CPQ measures 14 distinct personality factors; data on these variables were analyzed using a 2 x 2 (academic ability x sex) analysis of variance design. A stepwise discriminant…

Hunt, Dennis; Randhawa, Bikkar S.

170

Three Factors in Language Design  

Microsoft Academic Search

The biolinguistic perspective regards the language faculty as an organ of the body, along with other cognitive systems. Adopting it, we expect to find three factors that interact to determine (I-) languages attained: genetic endowment (the topic of Universal Grammar), experience, and principles that are language- or even organism-independent. Research has naturally focused on I-languages and UG, the problems of

Noam Chomsky

2005-01-01

171

Transcription factor-based biosensor  

SciTech Connect

The present invention provides for a system comprising a BmoR transcription factor, a .sigma..sup.54-RNA polymerase, and a pBMO promoter operatively linked to a reporter gene, wherein the pBMO promoter is capable of expression of the reporter gene with an activated form of the BmoR and the .sigma..sup.54-RNA polymerase.

2013-10-08

172

Transfer Factors for Contaminant Uptake  

E-print Network

Transfer Factors for Contaminant Uptake by Fruit and Nut Trees Office of Nuclear Regulatory of supply, upon written request as follows: Address: U.S. Nuclear Regulatory Commission Office thereof, nor any employee, makes any warranty, expressed or implied, or assumes any legal liability

173

Synthetic Division and Matrix Factorization  

ERIC Educational Resources Information Center

Synthetic division is viewed as a change of basis for polynomials written under the Newton form. Then, the transition matrices obtained from a sequence of changes of basis are used to factorize the inverse of a bidiagonal matrix or a block bidiagonal matrix.

Barabe, Samuel; Dubeau, Franc

2007-01-01

174

NASA Space Human Factors Program  

NASA Technical Reports Server (NTRS)

This booklet briefly and succinctly treats 23 topics of particular interest to the NASA Space Human Factors Program. Most articles are by different authors who are mainly NASA Johnson or NASA Ames personnel. Representative topics covered include mental workload and performance in space, light effects on Circadian rhythms, human sleep, human reasoning, microgravity effects and automation and crew performance.

1992-01-01

175

Heredity Factors in Spatial Visualization.  

ERIC Educational Resources Information Center

Spatial visualization is not yet clearly understood. Some researchers have concluded that two factors or abilities are involved, spatial orientation and spatial visualization. Different definitions and different tests have been proposed for these two abilities. Several studies indicate that women generally perform more poorly on spatial tests than…

Vandenberg, S. G.

176

Liver fibrogenesis and metabolic factors.  

PubMed

Mechanisms of liver fibrosis are complex and varied. Among them, metabolic factors are particularly important in the development of fibrosis associated with nonalcoholic steatohepatitis (NASH). These factors are some of the "multiple parallel hits" responsible for liver damage during NASH. Nonalcoholic fatty liver disease (NAFLD) is the hepatic manifestation of the metabolic syndrome. Major profibrogenic protagonists, such as hepatic stellate cells and Kupffer cells, are activated by insulin resistance, apoptosis and local inflammation. Relations between steatosis, insulin resistance and fibrosis are complex. Initially, simple steatosis may be a way to store deleterious free fatty acid in neutral triglycerides. If the lipid storage threshold is exceeded, steatosis may become associated with lipotoxicity. Similarly, interindividual variations of adipose tissue expandability might explain various phenotypes, ranging from "metabolically obese patients with normal weight" to "metabolically normal morbidly obese patients". The metabolic abnormalities in subcutaneous and visceral adipose tissue are insulin resistance and low-grade inflammation, which are associated with increased release of free fatty acid flux and changes in adipocytokines production such as leptin, adiponectin and interleukin 6. The nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR?) and the endocannabinoid system might have important roles in liver fibrogenesis and are potential therapeutic targets. Finally, with the development of new molecular tools, gut microbiota has been recently identified for its pleiotropic functions, including metabolism regulation. Better knowledge of these mechanisms should lead to new strategies for the treatment of metabolic factors that play a key role in liver injuries. PMID:21742296

Anty, Rodolphe; Lemoine, Maud

2011-06-01

177

Epidermal growth factor induced apoptosis  

Microsoft Academic Search

Apoptosis, or programmed cell death, plays an important role in the pathogenesis of a number of human diseases, including cancers, autoimmune diseases, and neurodegenerative disorders. Recent evidence suggests that EGF induced signal transduction pathways which govern cell proliferation and cell cycle progression also mediate antiproliferative effects leading to increased apoptosis in cells that express high levels of epidermal growth factor

K. B. Reddy

1996-01-01

178

Three phase power factor controller  

NASA Technical Reports Server (NTRS)

A power control circuit for a three phase induction motor is described. Power factors for the three phases are summed to provide a control signal, and this control signal is particularly filtered and then employed to control the duty cycle of each phase of input power to the motor.

Nola, F. J. (inventor)

1984-01-01

179

Three phase power factor controller  

NASA Technical Reports Server (NTRS)

A power control circuit for a three phase induction motor is described. The power factors for the three phases are summed to provide a control signal. This control signal is particularly filtered and then employed to control the duty cycle of each phase of input power to the motor.

Nola, F. J. (inventor)

1980-01-01

180

Human factors in underwater systems.  

PubMed

Applications of human factors to undersea engineering and the relationship to aerospace science are explored. Cooperative ventures include the TEKTITE underwater habitat and development of better procedures to prevent decompression sickness. Other research involved the use of alternate gases in diving systems, remote-operation vehicles, and diving system tests. PMID:11541030

Crosson, D

1993-10-01

181

Soft Factors Influence College Enrollment  

ERIC Educational Resources Information Center

Evidence about the role that "soft factors" like student engagement and school environment play in influencing whether high school students go on to enroll in college is hard to come by. Over the past two years, the Center for Labor Market Studies (CLMS) of Northeastern University, with support from the Nellie Mae Education Foundation and the…

Fogg, Neeta P.; Harrington, Paul E.

2010-01-01

182

Factors determining desert dune type  

Microsoft Academic Search

While most observers recognize four elemental types of desert dunes (longitudinal, transverse, barchan and star1-3) there is little agreement about which factors determine these types. The angular relationships between the resultant of sand shifting winds and both the crest and principal slipfaces of the elemental types have been discussed qualitatively for many decades. These relationships have been quantified but the

R. J. Wasson; R. Hyde

1983-01-01

183

Prognostic Factors in Hodgkin Lymphoma  

PubMed Central

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise. PMID:25045461

Cuccaro, Annarosa; Bartolomei, Francesca; Cupelli, Elisa; Galli, Eugenio; Giachelia, Manuela; Hohaus, Stefan

2014-01-01

184

Human Factors in Visualization Research  

Microsoft Academic Search

Abstract - Visualization can provide valuable assistance for data analysis and decision making tasks and interact with a visualization tool can strongly influence their understanding of the data as well as the system's usefulness factors therefore contribute significantly to the visualization process and should play an important role in the design and evaluation of visualization tools Several research initiatives have

Melanie Tory; Torsten Möller

2004-01-01

185

Psychological Factors Affecting Cardiologic Conditions  

Microsoft Academic Search

There are substantial data supporting a strong relationship between cardiovascular diseases and psychological conditions. However, the criteria for scientific validation of the entities currently subsumed under the DSM-IV category of ’Psychological factors affecting a medical condition’ have never been clearly enumerated and the terms ’psychological symptoms’ and ’personality traits’ that do not satisfy traditional psychiatric criteria are not well defined;

C. Rafanelli; R. Roncuzzi; F. Ottolini; M. Rigatelli

2007-01-01

186

Employability Development Teams: Cohesion Factors  

ERIC Educational Resources Information Center

In this study the researchers attempted to analyze the factors of age, sex, racial-ethnic background, operational life of the team, educational status, leader status, team size, caseload size, and the location of program site in terms of their potential effects upon team cohesion. (Author)

Johnson, Douglas W.; Munger, Paul F.

1972-01-01

187

Occupational factors and pancreatic cancer  

Microsoft Academic Search

The relation between occupational factors and pancreatic cancer has been studied by two different approaches: a population based case-control study with two series of controls and a retrospective cohort study based on register data. With both approaches, some support was found for an association with occupational exposure to petroleum products. Associations were also indicated with exposure to paint thinner (case-control

S Norell; A Ahlbom; R Olin; R Erwald; G Jacobson; I Lindberg-Navier; K L Wiechel

1986-01-01

188

Peak compression factor of proteins.  

PubMed

An experimental protocol is proposed in order to measure with accuracy and precision the band compression factor G(12)(2) of a protein in gradient RPLC. Extra-column contributions to bandwidth and the dependency of both the retention factor and the reduced height equivalent to a theoretical plate (HETP) on the mobile phase composition were taken into account. The band compression factor of a small protein (insulin, MW kDa) was measured on a 2.1mm x 50mm column packed with 1.7 microm C(4)-bonded bridged ethylsiloxane BEH-silica particles, for 1 microL samples of dilute insulin solution (<0.05g/L). A linear gradient profile of acetonitrile (25-28% acetonitrile in water containing 0.1% trifluoroacetic acid) was applied during three different gradient times (5, 12.5, and 20 min). The mobile phase flow rate was set at 0.20 mL/min in order to avoid heat friction effects (maximum column inlet pressure 180 bar). The band compression factor of insulin is defined as the ratio of the experimental space band variance measured under gradient conditions to the reference space band variance, which would be observed if no thermodynamic compression would take place during gradient elution. It was 0.56, 0.71, and 0.76 with gradient times of 5, 12.5, and 20 min, respectively. These factors are 20-30% smaller than the theoretical band compression factors (0.79, 0.89, and 0.93) calculated from an equation derived from the well-known Poppe equation, later extended to any retention models and columns whose HETP depends on the mobile phase composition. This difference is explained in part by the omission in the model of the effect of the pressure gradient on the local retention factor of insulin during gradient elution. A much better agreement is obtained for insulin when this effect is taken into account. For lower molecular weight compounds, the pressure gradient has little effect but the finite retention of acetonitrile causes a distortion of the gradient shape during the migration of its breakthrough front along the column. This phenomenon should be taken into account in the theoretical models. PMID:19604512

Gritti, Fabrice; Guiochon, Georges

2009-08-14

189

Prognostic Factors in Myelodysplastic Syndromes  

PubMed Central

ABSTRACT Background: Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myeloid leukemia. Because MDSs display remarkable clinical, pathologic, and cytogenetic heterogeneity, with variable evolution and survival ranging from months to years, the predictive factors of prognosis have a key role in optimal therapeutic decisions. The purpose of this paper is to analyze prognostic factors within a group of patients diagnosed with myelodysplastic syndromes. The prognostic factors taken into account are: the number and depth of cytopenias, percentage of bone marrow blasts, cytogenetic abnormalities, intensity of anemia and transfusional dependence. These factors are related to overall survival, leukemia free survival, bone marrow failure complications, leukemic evolution, treatment decisions and the response to treatment. Material and method: The study group comprises of 119 patients diagnosed with de novo MDS, between 2008 and 2011 in the Hematology Department of Coltea Clinical Hospital. In this monitoring period the patients were stratified according to the FAB (French-American-British) morphologic classification. Results: This study revealed that the outcomes of patients with MDS is influenced by the percentage of bone marrow blasts at diagnosis, the number and severity of hematopoietic lineage affected by cytopenia and by the presence of chromosomal abnormalities. Conclusions: The studied prognostic factors have predictive value in terms of survival, leukemic transformation, treatment response and development of bone marrow failure-related characteristic complications. PMID:23483702

TRIANTAFYLLIDIS, Irina; CIOBANU, Anca; STANCA, Oana; LUPU, Anca Roxana

2012-01-01

190

The Fermat factorization method revisited Robert Erra  

E-print Network

The Fermat factorization method revisited Robert Erra Christophe Grenier 30th June 2009 Abstract We consider the well known Fermat factorization method, we call the Fermat factorization equation the equation works. 1 Introduction Fermat, in a letter to Mersenne around 1643, exposed an algorithm to factor odd

191

The factorization of the ninth Fermat number  

Microsoft Academic Search

In this paper we exhibit the full prime factorization of the ninth Fermat number Fg = 2512 + 1 . It is the product of three prime factors that have 7, 49, and 99 decimal digits. We found the two largest prime factors by means of the number field sieve, which is a factoring algorithm that depends on arithmetic in

H. W. Lenstra; M. S. Manasse; J. M. Pollard

1993-01-01

192

Recombinant activated factor VII and the anaesthetist  

Microsoft Academic Search

Summary Recombinant activated factor VII is a safe and effective for the treatment and prevention of haemorrhage in haemophiliacs with circulating inhibitors to replacement factors, and patients with Glanzmann's thrombasthenia refractory to platelet transfusion. By restoring thrombin generation on the surface of tissue factor bearing cells, such as activated platelets and monocytes, recombinant activated factor VII has the potential to

I. J. Welsby; D. M. Monroe; J. H. Lawson; M. Hoffmann

2005-01-01

193

Mechanical factors affecting hemostasis and thrombosis  

Microsoft Academic Search

Both physical and chemical factors can influence the activity of platelets and coagulation factors responsible for the formation of thrombotic and hemostatic masses in the vicinity of an injured vessel wall. Studies performed in controlled shear devices (viscometers) have indicated that physical factors alone can induce platelet aggregation, even in the absence of exogenous chemical factors. The physical considerations which

Vincent T. Turitto; Connie L. Hall

1998-01-01

194

Bayesian Estimation of Categorical Dynamic Factor Models  

ERIC Educational Resources Information Center

Dynamic factor models have been used to analyze continuous time series behavioral data. We extend 2 main dynamic factor model variations--the direct autoregressive factor score (DAFS) model and the white noise factor score (WNFS) model--to categorical DAFS and WNFS models in the framework of the underlying variable method and illustrate them with…

Zhang, Zhiyong; Nesselroade, John R.

2007-01-01

195

Goal Orientations: Two, Three, or More Factors?  

ERIC Educational Resources Information Center

Goal orientation research has developed two branches. One branch uses a two-factor dispositional model. The other branch uses a three-factor domain-specific model. The present multiwave study examines dispositional goal orientation constructs through both two and three-factor models using repeated-measure confirmatory factor analysis. Results…

Attenweiler, William J.; Moore, DeWayne

2006-01-01

196

Factors Impacting Decommissioning Costs - 13576  

SciTech Connect

The Electric Power Research Institute (EPRI) studied United States experience with decommissioning cost estimates and the factors that impact the actual cost of decommissioning projects. This study gathered available estimated and actual decommissioning costs from eight nuclear power plants in the United States to understand the major components of decommissioning costs. Major costs categories for decommissioning a nuclear power plant are removal costs, radioactive waste costs, staffing costs, and other costs. The technical factors that impact the costs were analyzed based on the plants' decommissioning experiences. Detailed cost breakdowns by major projects and other cost categories from actual power plant decommissioning experiences will be presented. Such information will be useful in planning future decommissioning and designing new plants. (authors)

Kim, Karen; McGrath, Richard [Electric Power Research Institute, 3420 Hillview Ave., Palo Alto, California (United States)] [Electric Power Research Institute, 3420 Hillview Ave., Palo Alto, California (United States)

2013-07-01

197

Factors influencing susceptibility to metals.  

PubMed Central

Although the long-neglected field of human susceptibility to environmental toxicants is currently receiving renewed attention, there is only scant literature on factors influencing susceptibility to heavy metals. Genetic factors may influence the availability of sulfhydryl-containing compounds such as glutathione and metallothionein, which modify the distribution and toxicity of certain metals. Age and gender play a role in modifying uptake and distribution, although the mechanisms are often obscure. Concurrent exposure to divalent cations may enhance or reduce the toxicity of certain metals through competition for receptor-mediated transport or targets. Increasing use of biomarkers of exposure should greatly increase our understanding of the underlying distribution of susceptibility to various environmental agents. PMID:9255566

Gochfeld, M

1997-01-01

198

Factors influencing pacing in triathlon.  

PubMed

Triathlon is a multisport event consisting of sequential swim, cycle, and run disciplines performed over a variety of distances. This complex and unique sport requires athletes to appropriately distribute their speed or energy expenditure (ie, pacing) within each discipline as well as over the entire event. As with most physical activity, the regulation of pacing in triathlon may be influenced by a multitude of intrinsic and extrinsic factors. The majority of current research focuses mainly on the Olympic distance, whilst much less literature is available on other triathlon distances such as the sprint, half-Ironman, and Ironman distances. Furthermore, little is understood regarding the specific physiological, environmental, and interdisciplinary effects on pacing. Therefore, this article discusses the pacing strategies observed in triathlon across different distances, and elucidates the possible factors influencing pacing within the three specific disciplines of a triathlon. PMID:25258562

Wu, Sam Sx; Peiffer, Jeremiah J; Brisswalter, Jeanick; Nosaka, Kazunori; Abbiss, Chris R

2014-01-01

199

Human factors in waste management  

SciTech Connect

This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

Moray, N. [Univ. of Illinois, Urbana, IL (United States)

1994-10-01

200

Risk factors for placenta accreta  

Microsoft Academic Search

Objective: To identify risk factors associated with placenta accreta in a large cohort study.Methods: Data for this study came from the Taiwan Down Syndrome Screening Group, an ongoing project on feasibility of serum screening in an Asian population. Women who had serum screening for Down syndrome at 14–22 weeks’ gestation using alpha-fetoprotein (AFP) and free ?-hCG between January 1994 and

Tai-Ho Hung; Wen-Yi Shau; Ching-Chang Hsieh; Tsung-Hong Chiu; Jenn-Jeih Hsu; T’Sang-T’Ang Hsieh

1999-01-01

201

Human Factors and Medical Devices  

Microsoft Academic Search

Medical device hardware- and software-driven user interfaces should be designed to minimize the likelihood of use-related errors and their consequences. The role of design-induced errors in medical device incidents is attracting widespread attention. The U.S. Food and Drug Administration (FDA) is fully cognizant that human factors engineering is critical to the design of safe medical devices, and user interface design

Dick Sawyer

1998-01-01

202

Human Factors in Space Exploration  

NASA Technical Reports Server (NTRS)

The exploration of space is one of the most fascinating domains to study from a human factors perspective. Like other complex work domains such as aviation (Pritchett and Kim, 2008), air traffic management (Durso and Manning, 2008), health care (Morrow, North, and Wickens, 2006), homeland security (Cooke and Winner, 2008), and vehicle control (Lee, 2006), space exploration is a large-scale sociotechnical work domain characterized by complexity, dynamism, uncertainty, and risk in real-time operational contexts (Perrow, 1999; Woods et ai, 1994). Nearly the entire gamut of human factors issues - for example, human-automation interaction (Sheridan and Parasuraman, 2006), telerobotics, display and control design (Smith, Bennett, and Stone, 2006), usability, anthropometry (Chaffin, 2008), biomechanics (Marras and Radwin, 2006), safety engineering, emergency operations, maintenance human factors, situation awareness (Tenney and Pew, 2006), crew resource management (Salas et aI., 2006), methods for cognitive work analysis (Bisantz and Roth, 2008) and the like -- are applicable to astronauts, mission control, operational medicine, Space Shuttle manufacturing and assembly operations, and space suit designers as they are in other work domains (e.g., Bloomberg, 2003; Bos et al, 2006; Brooks and Ince, 1992; Casler and Cook, 1999; Jones, 1994; McCurdy et ai, 2006; Neerincx et aI., 2006; Olofinboba and Dorneich, 2005; Patterson, Watts-Perotti and Woods, 1999; Patterson and Woods, 2001; Seagull et ai, 2007; Sierhuis, Clancey and Sims, 2002). The human exploration of space also has unique challenges of particular interest to human factors research and practice. This chapter provides an overview of those issues and reports on sorne of the latest research results as well as the latest challenges still facing the field.

Jones, Patricia M.; Fiedler, Edna

2010-01-01

203

Spinach protein factor and chlorophyllase  

Microsoft Academic Search

1.Spinach leaves contain a “Spinach Protein Factor” (SPF) which increases light sensitivity of colloidal chlorophylls in aqueous solution (Terpstra, 1967). SPF activity, measured in different fractions of spinach-leaf acetone-powder extracts obtained by gel filtration on DEAE- and CM-Sephadex, runs parallel with chlorophyllase activity. The same positive correlation is generally observed in aqueous extracts of certain small particles isolated from spinach-leaf

Willemke Terpstra; A. C. M. Weijman

1972-01-01

204

Ecological Factors Affecting Community Invasibility  

Microsoft Academic Search

What makes a community invasible? For over a century ecologists have sought to understand the relative importance of biotic\\u000a and abiotic factors that determine community composition. The fact that we are still exploring this topic today hints at both\\u000a its importance and complexity. As the impacts from harmful non-native species accumulate, it has become increasingly urgent\\u000a to find answers to

Suzanne V. Olyarnik; Matthew E. S. Bracken; Jarrett E. Byrnes; A. Randall Hughes; Kristin M. Hultgren; John J. Stachowicz

205

Electrical and Production Load Factors  

E-print Network

2. Comparison of SIC and NAICS Codes -20Food and Kindred Products 311 - Food Manufacturing 312 - Beverage and Tobacco Product Manufacturing 313 22 Textile Mill Products 315 23 Apparel And Other Finished Fabric Products 321 24 Lumber...Measuring, Analyzing, Controlling Instruments; Photographic, Medical, Optical Goods; Watches 339 39 Miscellaneous Manufacturing 511 - Publishing Industries (except Internet) Description 334 - 335 - NAICS Code SIC Code The load factors presented...

Sen, T.; Heffington, W. M.

206

Human factors in incident reporting  

NASA Technical Reports Server (NTRS)

The paper proposes a cooperative research effort be undertaken by academic institutions and industry organizations toward the compilation of a human factors data base in conjunction with technical information. Team members in any discipline can benefit and learn from observing positive examples of decision making and performance by crews under stressful or less than optimal circumstances. The opportunity to note trends in interpersonal and interactive behaviors and to categorize them is terms of more or less desirable outcomes should not be missed.

Jones, S. G.

1993-01-01

207

Factors Influencing Wind Energy Curtailment  

Microsoft Academic Search

Nonphysically firm wind generation connections (i.e., those to which curtailment can apply) may be necessary for signifi- cant wind integration to congested transmission networks. A study of factors influencing this associated wind energy curtailment is, therefore,oftimelyimportance.Inthispaper,thewindcurtailment estimation effects of natural inter-yearly wind profile variability, systemdemand-profile\\/fuel-priceparameteruncertainty,andmin- imum system inertial constraints are studied in detail. Results in- dicate that curtailment estimation error

Daniel J. Burke; Mark J. O'Malley

2011-01-01

208

Circulating Vascular Endothelial Growth Factor  

Microsoft Academic Search

Despite significant advances in early detection and treatment, breast cancer still remains the major cause of cancer-related\\u000a death in women. Many studies suggest a relationship between angiogenesis and breast cancer prognosis. Angiogenesis is the\\u000a complex process leading to the formation of new blood vessels from pre-existing vascular network. The VEGF is the most active\\u000a growth factor involved in angiogenesis; more

Roberta Sarmiento; Roberta Franceschini; Sabrina Meo; Massimo Gion; Raffaele Longo; Giampietro Gasparini

209

Impact fact-or fiction?  

PubMed

The Journal Impact Factor dominates research assessment in many disciplines and in many countries. While research assessment will always have to rely to some extent on quantitative, standardized metrics, the focus on this single measure has gone so far as to hamper and distort scientific research. The Declaration on Research Assessment (DORA), signed by influential journals, funders, academic institutions and individuals across the natural sciences, aims to raise awareness and to redress the use of non-objective research assessment practices. PMID:23685358

Pulverer, Bernd

2013-06-12

210

EM Form Factors and OLYMPUS  

NASA Astrophysics Data System (ADS)

The elastic form factors of the nucleon characterize the distributions of charge and magnetization in momentum space and are important input for calculations of strong interaction phenomena and nuclear structure. The dramatic discrepancy in the observed ratio of elastic proton form factors between the Rosenbluth separation and polarization transfer methods has invoked numerous theoretical and experimental investigations. The previously neglected effect from two-photon exchange has become the favored explanation for the discrepancy. While the effect can not be calculated from first principles, it can be verified experimentally in several ways, most stringently by comparing the positron- proton and electron-proton elastic cross sections. The OLYMPUS experiment at DESY has been carried out to quantify the effect of two-photon exchange using intense stored positron and electron beams along with an internal unpolarized hydrogen target and a large acceptance detector to measure the ratio of the positron-proton and electron-proton elastic scattering cross sections. The status of proton form factor measurements and of the experimental efforts to verify the effect of two-photon exchange is presented, with some emphasis on the OLYMPUS experiment.

Kohl, Michael

2014-11-01

211

Quantum Computers, Factoring, and Decoherence  

E-print Network

In a quantum computer any superposition of inputs evolves unitarily into the corresponding superposition of outputs. It has been recently demonstrated that such computers can dramatically speed up the task of finding factors of large numbers -- a problem of great practical significance because of its cryptographic applications. Instead of the nearly exponential ($\\sim \\exp L^{1/3}$, for a number with $L$ digits) time required by the fastest classical algorithm, the quantum algorithm gives factors in a time polynomial in $L$ ($\\sim L^2$). This enormous speed-up is possible in principle because quantum computation can simultaneously follow all of the paths corresponding to the distinct classical inputs, obtaining the solution as a result of coherent quantum interference between the alternatives. Hence, a quantum computer is sophisticated interference device, and it is essential for its quantum state to remain coherent in the course of the operation. In this report we investigate the effect of decoherence on the quantum factorization algorithm and establish an upper bound on a ``quantum factorizable'' $L$ based on the decoherence suffered per operational step.

I. Chuang; Raymond Laflamme; P. Shor; W. Zurek

1995-03-08

212

Cardiac risk factors: environmental, sociodemographic, and behavioral cardiovascular risk factors.  

PubMed

Several environmental exposures are associated with increased risk of coronary heart disease (CHD). Exposure to secondhand smoke may increase the risk by as much as 25% to 30%. Exposure to third hand smoke, residual components of tobacco smoke that remain in the environment after a cigarette is extinguished, also appears to increase risk. These residual components can remain in rooms and automobiles for up to 30 years and enter the body through the skin or via inhalation or ingestion. Exposure to particulate matter air pollution from automobile emissions, power plants, and other sources is yet another environmental risk factor for CHD, resulting in tens of thousands of deaths annually in the United States. Exposure to other environmental toxins, particularly bisphenol A and phthalates, also has been linked to CHD. There are sociodemographic risks for CHD, with numerous studies showing that lower socioeconomic status is associated with higher risk. Behavioral risk factors include poor diet, such as frequent consumption of fast food and processed meals; sleep disturbance; and psychological stress, particularly related to marital or work issues. Finally, although high alcohol consumption is associated with increased CHD risk, moderate alcohol consumption (ie, less than 1 to 2 drinks/day), particularly of wine and possibly beer, appears to reduce the risk. PMID:24936715

Anthony, David; George, Paul; Eaton, Charles B

2014-06-01

213

Understanding adverse events: human factors.  

PubMed Central

(1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole. PMID:10151618

Reason, J

1995-01-01

214

Information criterion for selection of ubiquitous factors  

NASA Astrophysics Data System (ADS)

Factor analysis is a statistical procedure to describe observed data in terms of unobserved variables called factors. Naturally, it is necessary to determine the number of factors to represent the system. There are several existent criteria to deal with the tradeoff between reduction of approximation error and avoidance of overparameterization. However, given the factors there is a lack of an approach to verify if they are really equally inherent to the entire data. In this paper, the term ubiquitous factors is coined to describe such equally omnipresent factors. An information criterion is proposed to fill the existent blank. Additionally, we show the possibility to use the criterion to compare ubiquity of factors from two different techniques: principal component analysis and non-negative matrix factorization. Finally, the proposed criterion is extended to identify factors more suitable to describe only a partition of the data.

Takada, Hellinton H.; Stern, Julio M.

2015-01-01

215

Modifications of Coronary Risk Factors  

PubMed Central

In addition to the revascularization and glycemic management interventions assigned at random, the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) design includes the uniform control of major coronary artery disease risk factors, including dyslipidemia, hypertension, smoking, central obesity, and sedentary lifestyle. Target levels for risk factors were adjusted throughout the trial to comply with changes in recommended clinical practice guidelines. At present, the goals are low-density lipoprotein cholesterol <2.59 mmol/L (<100 mg/dL) with an optional goal of <1.81 mmol/L (<70 mg/dL); plasma triglyceride level <1.70 mmol/L (<150 mg/dL); blood pressure level <130 mm Hg systolic and <80 mm Hg diastolic; and smoking cessation treatment for all active smokers. Algorithms were developed for the pharmacologic management of dyslipidemia and hypertension. Dietary prescriptions for the management of glycemia, plasma lipid profiles, and blood pressure levels were adapted from existing clinical practice guidelines. Patients with a body mass index >25 were prescribed moderate caloric restriction; after the trial was under way, a lifestyle weight-management program was instituted. All patients were formally prescribed both endurance and resistance/flexibility exercises, individually adapted to their level of disability and fitness. Pedometers were distributed as a biofeedback strategy. Strategies to achieve the goals for risk factors were designed by BARI 2D working groups (lipid, cardiovascular and hypertension, and nonpharmacologic intervention) and the ongoing implementation of the strategies is monitored by lipid, hypertension, and lifestyle intervention management centers. PMID:16813737

Albu, Jeanine; Gottlieb, Sheldon H.; August, Phyllis; Nesto, Richard W.; Orchard, Trevor J.

2009-01-01

216

Colic anastomotic leakage risk factors  

PubMed Central

Abstract Background: Anastomotic leakage is a dreaded complication of colorectal surgery, as it greatly increases the morbidity, mortality and has been associated with augmented local recurrence and diminished survival. The frequency of this complication is high in emergency colorectal surgery, especially for bowel occlusion, (13% for emergency vs. 4% in elective), due to visceral distension and, therefore, an incongruence in the size of each of the stumps, combined with the lack of mechanical preparation and risk of fecal contamination during operation. Methods: We studied the incidence of anastomotic fistula in the surgery clinic of the “Sf. Pantelimon” Emergency Hospital, between 2006 and 2010, on a lot of 251 patients who underwent different types of colic resection. Apart from the anatomic location of the disease, and the level of anastomosis, we included in our database the following criteria: the patient’s age and gender, type of colic pathology, surgical technique, emergency or elective surgery, comorbidities. Results: An ileocolic anastomosis was performed for 84 patients (33,46 %), for 114 patients (45,41%) a colo-colic anastomosis was carried out, 2 patients (0,79%) had ileorectal anastomosis and 51 patients (20,31%) underwent a colorectal anastomosis. From the comparative analysis of risk factors (the emergency interventions, the anastomosis location, the age and gender of the patient), a significantly increased value of the relative risk of anastomotic fistula was registered for the cases with emergency intervention (x 6,61) and for the colorectal anastomosis following the left hemi colectomies (x 2,23). Discussions: In our study, among the clinical and biological factors analyzed, emergency intervention was the most signi?cant factor associated with anastomotic leakage. Surgery performed in emergency settings, on debilitated patients without adequate preoperative preparation, has an increased risk for anastomotic dehiscence. PMID:24868253

Calin, MD; B?l?l?u, C; Popa, F; Voiculescu, S; Sc?una?u, RV

2013-01-01

217

Weak-shock reflection factors  

SciTech Connect

The purpose of this paper is to compare reflection factors for weak shocks from various surfaces, and to focus attention on some unsolved questions. Three different cases are considered: square-wave planar shock reflection from wedges; square-wave planar shock reflection from cylinders; and spherical blast wave reflection from a planar surface. We restrict ourselves to weak shocks. Shocks with a Mach number of M{sub O} < 1.56 in air or with an overpressure of {Delta}{sub PI} < 25 psi (1.66 bar) under normal ambient conditions are called weak.

Reichenbach, H. [Ernst Mach Inst., Freiburg (Germany); Kuhl, A.L. [Lawrence Livermore National Lab., El Segundo, CA (United States)

1993-09-07

218

Human Factors in Space Flight  

NASA Technical Reports Server (NTRS)

After forty years of experience with human space flight (Table 1), the current emphasis is on the design of space vehicles, habitats, and missions to ensure mission success. What lessons have we learned that will affect the design of spacecraft for future space exploration, leading up to exploring Mars? This chapter addresses this issue in four sections: Anthropometry and Biomechanics; Environmental Factors; Habitability and Architecture; and Crew Personal Sustenance. This introductory section introduces factors unique to space flight. A unique consideration for design of a habitable volume in a space vehicle is the lack of gravity during a space flight, referred to as microgravity. This affects all aspects of life, and drives special features in the habitat, equipment, tools, and procedures. The difference in gravity during a space mission requires designing for posture and motion differences. In Earth s gravity, or even with partial gravity, orientation is not a variable because the direction in which gravity acts defines up and down. In a microgravity environment the working position is arbitrary; there is no gravity cue. Orientation is defined primarily through visual cues. The orientation within a particular crew station or work area is referred to as local vertical, and should be consistent within a module to increase crew productivity. Equipment was intentionally arranged in various orientations in one module on Skylab to assess the efficiency in use of space versus the effects of inconsistent layout. The effects of that arrangement were confusion on entering the module, time spent in re-orientation, and conflicts in crew space requirements when multiple crew members were in the module. Design of a space vehicle is constrained by the three major mission drivers: mass, volume and power. Each of these factors drives the cost of a mission. Mass and volume determine the size of the launch vehicle directly; they can limit consumables such as air, water, and propellant; and they impact crew size and the types of activities the crew performs. Power is a limiting factor for a space vehicle. All environmental features (e.g., atmosphere, temperature, lighting) require power to maintain them. Power can be generated from batteries, from fuel cells, or from solar panels. Each of these sources requires lifting mass and volume from Earth, driving mission cost. All engineering decisions directly impact the design for habitation design and usage. For instance, if fuel cells are used they produce water, which is used for drinking and food preparation. If a different power source is used water has to be carried and stored on the vehicle which then directly impacts the food system choice as well as the launch weight of the vehicle.

Woolford, Barbara J.; Mount, Frances

2005-01-01

219

Growth Factors in Clinical Practice  

Microsoft Academic Search

Growth factors enhance protein synthesis\\u000a and thus reduce the catabolic response to injury. As a result of\\u000a bioengineering and new manufacturing techniques several anabolic agents\\u000a have become available for clinical use and have been evaluated in\\u000a surgical patients with catabolic illness. Data support the anabolic\\u000a effects of growth home in such patients, but its expense and possible\\u000a deleterious effects during

2000-01-01

220

Lipid-bound factor Xa regulates tissue factor activity.  

PubMed

The activation of coagulation factor X by tissue factor (TF) and coagulation factor VIIa (VIIa) on a phospholipid surface is thought to be the key step in the initiation of blood coagulation. In this reaction, the product, fXa, is transiently and reversibly bound to the TF-VIIa enzyme complex. This in effect leads to a probabilistic inhibition of subsequent fX activations; a new fX substrate molecule cannot be activated until the old fXa molecule leaves. In this study, we demonstrate that benzamidine and soybean trypsin inhibitor-conjugated Sepharose beads, which bind fXa and sequester it away from the reaction, serve to enhance fX activation by the TF-VIIa complex. Thus, removal of fXa from the reactive zone, by either flow, fXa sequestration, or binding to distant lipid surfaces, can serve to enhance the levels of TF-VIIa activity. Using resonance energy transfer, we found the dissociation constants of fX and fXa for 100 nm diameter phospholipid vesicles to be on the order of 30-60 nM, consistent with previous measurements employing planar lipid surfaces. On the basis of the measurements of binding of fXa to phospholipid surfaces, we demonstrate that the rates of fX activation by the TF-VIIa complex under a variety of experimental conditions depend inversely on the amount of product (fXa) bound to the TF-phospholipid surface. These data support an inhibitory role for the reaction product, fXa, and indicate that models previously employed in understanding this initial coagulation reaction must now be re-evaluated to account for both the product occupancy of the phospholipid surface and the binding of the product to the enzyme. Moreover, the inhibitory properties of fXa can be described on the basis of the estimated surface density of fXa molecules on the TF-phospholipid surface. PMID:17469850

Hathcock, James; Rusinova, Elena; Vaananen, Heikki; Nemerson, Yale

2007-05-22

221

Specificity factors in cytoplasmic polyadenylation  

PubMed Central

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3? untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, ?CP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man. © 2013 John Wiley & Sons, Ltd. PMID:23776146

Charlesworth, Amanda; Meijer, Hedda A; de Moor, Cornelia H

2013-01-01

222

Is renin a risk factor?  

PubMed Central

1. These results show that elevated blood pressure and a hyperlipidemic diet exacerbate atherogenesis in the two kidney, one-clip hypertensive rabbit. Elevated PRA activity was not essential for the hypertension and did not exacerbate atherogenesis. 2. In addition, the experimentally induced, low renin state following DOC-saline did not result in a protective effect on cardiovascular lesions in rabbits fed an atherogenic diet when compared to normal renin controls. 3. Thus, in these experiments neither an increase in plasma renin accelerated atherogenesis, nor did a decrease in PRA slow the rate of production of atherosclerosis in the rabbit. 4. These observations lend no support to the thesis that renin is an independent risk factor when it is generated within the body in response to these stimuli. Indeed, it suggests that in this setting other factors, not PRA, are responsible for both hypertension in the two-kidney, one-clip rabbit and the arterial damage which occurs in this hypercholesterolemic model. PMID:7025426

Kirkendall, W. M.; Overturf, M. L.; Druilhet, R. E.

1981-01-01

223

Prognostic factors in ovarian cancer.  

PubMed

The improvement in the treatment of ovarian cancer is based on the recognition of the prognostic factors. The 5-year survival rate of 174 patients with epithelial ovarian malignancies after primary operation at the University Department of Obstetrics and Gynecology in Ljubljana and treated with adjuvant therapy at the Institute of Oncology in Ljubljana in the period 1970-1980 was 29.3% (56% for stage I, 36% for stage II, 23% for stage III and 4.5% for stage IV). The amount of residual tumor after the primary operation was prognostically very important (5-year survival in stage III in cases of residual tumor less than 2 cm is 46.6%, in tumor greater than 2 cm only 18.6%). The histological type of tumor, considering the stage, was not important prognostically. On the contrary the grade of differentiation was prognostically very important even in advanced cases: 5 year survival for stage III in cases of well differentiated serous tumors was 61%, in moderately and poorly differentiated cases it was only 7%. Younger patients have better prognosis than older ones, because the tumors are better differentiated, too. Since ovarian cancers are diagnosed too late in 65% of cases in advanced stages, today all efforts should be focussed on early diagnosis, which is probably the only factors that can lead to the dramatic fall of the mortality rate. PMID:2170137

Rakar, S; Kovacic, J; Cavic, M; Lukanovic, A; Mozina, A

1990-01-01

224

Risk factors of ?-hydroxybutyrate overdosing.  

PubMed

The aim of this study was to identify in recreational drug users the factors which increase the risk of overdosing (OD) with ?-hydroxybutyrate (GHB). A purposive sample of 45 experienced GHB users was interviewed, equally divided into three groups (never OD, occasional OD, and repeat OD). The repeat OD group scored highest on many risk factors regarding GHB use, the occasional OD group scored intermediate, and the never OD group scored lowest. Participants, whether or not they had overdosed on GHB, most often perceived GHB use (e.g. using more GHB than usual, using GHB doses too closely together) as the main reason for GHB OD, and many participants who had overdosed on GHB reported that they had taken more GHB than usual at their most recent occasion of GHB OD. No significant differences in co-use of GHB with other substances were found between the three groups. Our findings indicate that using GHB in the company of groups of friends probably reduces, but does not eliminate, the risk of OD. PMID:24080792

Korf, Dirk J; Nabben, Ton; Benschop, Annemieke; Ribbink, Kim; van Amsterdam, Jan G C

2014-01-01

225

Nucleosomes accelerate transcription factor dissociation  

PubMed Central

Transcription factors (TF) bind DNA-target sites within promoters to activate gene expression. TFs target their DNA-recognition sequences with high specificity by binding with resident times of up to hours in vitro. However, in vivo TFs can exchange on the order of seconds. The factors that regulate TF dynamics in vivo and increase dissociation rates by orders of magnitude are not known. We investigated TF binding and dissociation dynamics at their recognition sequence within duplex DNA, single nucleosomes and short nucleosome arrays with single molecule total internal reflection fluorescence (smTIRF) microscopy. We find that the rate of TF dissociation from its site within either nucleosomes or nucleosome arrays is increased by 1000-fold relative to duplex DNA. Our results suggest that TF binding within chromatin could be responsible for the dramatic increase in TF exchange in vivo. Furthermore, these studies demonstrate that nucleosomes regulate DNA–protein interactions not only by preventing DNA–protein binding but by dramatically increasing the dissociation rate of protein complexes from their DNA-binding sites. PMID:24353316

Luo, Yi; North, Justin A.; Rose, Sean D.; Poirier, Michael G.

2014-01-01

226

Risk factors for tornado injuries.  

PubMed

Tornadoes in North and South Carolina on 28 March 1984 caused 252 people to be injured seriously enough to require hospitalization and 59 to be killed. To evaluate risk factors, we gathered information on 238 (94%) of those hospitalized and 46 (78%) of those killed. Those hospitalized or deceased had statistically significantly more deep cuts, concussions, unconsciousness and broken bones than those with them at the time of the tornado who were not hospitalized or killed. People living in mobile homes were more likely to be hospitalized or die than people occupying conventional houses. Other risk factors for hospitalization or death included advanced age (60+ years), no physical protection (not having been covered with a blanket or other object), having been struck by broken window glass or other falling objects, home lifted off its foundation, collapsed ceiling or floor, or walls blown away. More awareness of the tornado risk before it strikes and better adherence to tornado protection guidelines could reduce injuries and deaths in the future. PMID:2083989

Eidson, M; Lybarger, J A; Parsons, J E; MacCormack, J N; Freeman, J I

1990-12-01

227

Regulation of Myocyte Enhancer Factor-2 Transcription Factors by Neurotoxins  

PubMed Central

Various isoforms of myocyte enhancer factor-2 (MEF2) constitute a group of nuclear proteins found to play important roles in increasing types of cells. In neurons, MEF2s are required to regulate neuronal development, synaptic plasticity, as well as survival. MEF2s promote the survival of several types of neurons under different conditions. In cellular models, negative regulation of MEF2s by stress and toxic signals contributes to neuronal death. In contrast, enhancing MEF2 activity not only protects cultured primary neurons from death in vitro but also attenuates the loss of dopaminergic neurons in substantia nigra pars compacta in a 1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. In this work, the mechanisms of regulation of MEF2 function by several well-known neurotoxins and their implications in various neurodegenerative diseases are reviewed. PMID:21741404

She, Hua; Mao, Zixu

2011-01-01

228

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2013-10-01

229

48 CFR 2015.304 - Evaluation factors.  

...2014-10-01 2014-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2014-10-01

230

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2012-10-01

231

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2011-10-01

232

ARITHMETIC PROGRESSIONS IN A UNIQUE FACTORIZATION DOMAIN  

E-print Network

ARITHMETIC PROGRESSIONS IN A UNIQUE FACTORIZATION DOMAIN. We give a new proof of a slight generalization of this result to arithmetic progressions of integers and further extend it to arithmetic progressions in unique factorization domains

Ghorpade, Sudhir

233

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 true Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2010-10-01

234

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2011-01-01

235

14 CFR 460.15 - Human factors.  

...2014-01-01 2014-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2014-01-01

236

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2012-01-01

237

Human Factors in Intelligence, Surveillance, and Reconnaissance  

E-print Network

Human Factors in Intelligence, Surveillance, and Reconnaissance: Gaps for Soldiers and Technology Recommendations Jonathan Z. Bakdash Human Research and Engineering Directorate U.S. Army Research Laboratory gaps, we use approaches from Human Factors (interactions between humans and technical systems

Preece, Alun

238

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2013-01-01

239

EXPOSURE FACTORS HANDBOOK (EXTERNAL REVIEW DRAFT) 1996  

EPA Science Inventory

This handbook provided a summary of the available statistical data on various factors used in assessing human exposure. Volume I, General Factors, includes an introduction and discussion of uncertainty and provides data for drinking water consumption, soil ingestion, inha...

240

Capacity Factor Risk At Nuclear Power Plants  

E-print Network

We develop a model of the dynamic structure of capacity factor risk. It incorporates the risk that the capacity factor may vary widely from year-to-year, and also the risk that the reactor may be permanently shutdown prior ...

Du, Yangbo

241

Cone Penetrometer N Factor Determination Testing Results  

SciTech Connect

This document contains the results of testing activities to determine the empirical 'N Factor' for the cone penetrometer in kaolin clay simulant. The N Factor is used to releate resistance measurements taken with the cone penetrometer to shear strength.

Follett, Jordan R.

2014-03-05

242

What Is Human Factors/Usability Engineering?  

MedlinePLUS

... Human Factors in Medical Devices: Design, Regulation, and Patient Safety" CDRH Human Factors Research Projects (Most Recent) UPCARE: ... Order) Agency for Healthcare Research and Quality (AHRQ): Patient Safety Agency for Healthcare Research and Quality (AHRQ): Making ...

243

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2011 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2011-04-01

244

23 CFR 650.707 - Rating factor.  

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2014-04-01

245

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2010 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2010-04-01

246

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2012 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2012-04-01

247

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2013 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2013-04-01

248

14 CFR 31.43 - Fitting factor.  

Code of Federal Regulations, 2011 CFR

...and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.43 Fitting factor. (a) A fitting factor of at least 1.15 must be used in...

2011-01-01

249

14 CFR 31.43 - Fitting factor.  

Code of Federal Regulations, 2013 CFR

...and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.43 Fitting factor. (a) A fitting factor of at least 1.15 must be used in...

2013-01-01

250

14 CFR 31.43 - Fitting factor.  

...and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.43 Fitting factor. (a) A fitting factor of at least 1.15 must be used in...

2014-01-01

251

14 CFR 31.43 - Fitting factor.  

Code of Federal Regulations, 2010 CFR

...and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.43 Fitting factor. (a) A fitting factor of at least 1.15 must be used in...

2010-01-01

252

14 CFR 31.43 - Fitting factor.  

Code of Federal Regulations, 2012 CFR

...and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT AIRWORTHINESS STANDARDS: MANNED FREE BALLOONS Design Construction § 31.43 Fitting factor. (a) A fitting factor of at least 1.15 must be used in...

2012-01-01

253

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2012 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2012-07-01

254

40 CFR 1033.245 - Deterioration factors.  

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2014-07-01

255

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2013 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2013-07-01

256

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2011 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2011-07-01

257

About Alzheimer's Disease: Risk Factors and Prevention  

MedlinePLUS

... National Alzheimer's Project Act (NAPA) About ADEAR About Alzheimer's Disease: Risk Factors and Prevention We can’t control some risk factors for Alzheimer's disease such as age and genetic profile. But scientists ...

258

Using Simulated Annealing to Factor Numbers  

E-print Network

Almost all public secure communication relies on the inability to factor large numbers. There is no known analytic or classical numeric method to rapidly factor large numbers. Shor[1] has shown that a quantum computer can factor numbers in polynomial time but there is no practical quantum computer that can yet do such computations. We show that a simulated annealing[2] approach can be adapted to find factors of large numbers.

Eric Lewin Altschuler; Timothy J. Williams

2014-02-14

259

The pH Factor  

NSDL National Science Digital Library

The Miami Museum of Science's learning site, The pH Factor, gives teachers a fun and interactive way to teach elementary and middle school students some basics of science. Material is divided into seven learning areas: excite, explore, explain, expand, extend, exchange, and examine. Each contains an interactive screen that can be used directly in the classroom and lesson plans that correspond with each subject. For example, the excite area contains the "tasting tongue" that, when clicked, shows the location on the tongue where you taste bitter or sour things. The site's teaching style is based on the proposition that learners need to build their own understanding of new ideas. The unique material that is offered on this site provides educators with an excellent alternative for teaching these sometimes difficult concepts to grade school students.

260

Manned Mars mission crew factors  

NASA Technical Reports Server (NTRS)

Crew factors include a wide range of concerns relating to the human system and its role in a Mars mission. There are two important areas which will play a large part in determining the crew for a Mars mission. The first relates to the goals and priorities determined for such a vast endeavor. The second is the design of the vehicle for the journey. The human system cannot be separated from the other systems in that vehicle. In fact it will be the human system which drives the development of many of the technical breakthroughs necessary to make a Mars mission successful. As much as possible, the engineering systems must adapt to the needs of the human system and its individual components.

Santy, Patricia A.

1986-01-01

261

Clinical Factors Associated with PANDAS  

PubMed Central

Objective To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). Study design Children with tics and/or OCD (n = 109) were examined by personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies. Results Significant group differences were found on several variables, such that those diagnosed with PANDAS (versus without PANDAS) were more likely to have had dramatic onset; definite remissions; remission of neuropsychiatric symptoms during antibiotic therapy; a history of tonsillectomies/adenoidectomies; evidence of GAS infection, and clumsiness. Conclusion The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of OCD/tics. PMID:21868033

Murphy, Tanya K.; Storch, Eric A.; Lewin, Adam B.; Edge, Paula J.; Goodman, Wayne K.

2011-01-01

262

The Main Aeromonas Pathogenic Factors  

PubMed Central

The members of the Aeromonas genus are ubiquitous, water-borne bacteria. They have been isolated from marine waters, rivers, lakes, swamps, sediments, chlorine water, water distribution systems, drinking water and residual waters; different types of food, such as meat, fish, seafood, vegetables, and processed foods. Aeromonas strains are predominantly pathogenic to poikilothermic animals, and the mesophilic strains are emerging as important pathogens in humans, causing a variety of extraintestinal and systemic infections as well as gastrointestinal infections. The most commonly described disease caused by Aeromonas is the gastroenteritis; however, no adequate animal model is available to reproduce this illness caused by Aeromonas. The main pathogenic factors associated with Aeromonas are: surface polysaccharides (capsule, lipopolysaccharide, and glucan), S-layers, iron-binding systems, exotoxins and extracellular enzymes, secretion systems, fimbriae and other nonfilamentous adhesins, motility and flagella. PMID:23724321

Tomás, J. M.

2012-01-01

263

Form factors from lattice QCD  

SciTech Connect

Precision computation of hadronic physics with lattice QCD is becoming feasible. The last decade has seen precent-level calculations of many simple properties of mesons, and the last few years have seen calculations of baryon masses, including the nucleon mass, accurate to a few percent. As computational power increases and algorithms advance, the precise calculation of a variety of more demanding hadronic properties will become realistic. With this in mind, I discuss the current lattice QCD calculations of generalized parton distributions with an emphasis on the prospects for well-controlled calculations for these observables as well. I will do this by way of several examples: the pion and nucleon form factors and moments of the nucleon parton and generalized-parton distributions.

Dru Renner

2012-04-01

264

Kleptomania and Potential Exacerbating Factors  

PubMed Central

Kleptomania is an impulse control disorder that can cause significant impairment and serious consequences. Often, the condition is kept secret by the patient, and usually help is sought only when confronted by the legal consequences of the impulsive behaviors. Historically, kleptomania has been viewed from a psychodynamic perspective, and the mainstay of treatment has been psychotherapy. Recently, attempts to explain kleptomania within a neuropsychiatric paradigm have highlighted the possible links between mood disorders, addictive behaviors, and brain injury with kleptomania. These associations with kleptomania can be extrapolated to pharmacological strategies that can potentially help in treating kleptomania. A case of kleptomania, which was potentially exacerbated by multiple factors, will be reviewed. Treatment modalities used in this case, including the use of the Yale-Brown Obsessive Compulsive Scale as a surrogate marker to gauge response to treatment, will be discussed. PMID:22132369

2011-01-01

265

Occupational factors and pancreatic cancer.  

PubMed

The relation between occupational factors and pancreatic cancer has been studied by two different approaches: a population based case-control study with two series of controls and a retrospective cohort study based on register data. With both approaches, some support was found for an association with occupational exposure to petroleum products. Associations were also indicated with exposure to paint thinner (case-control study) and work in painting and in paint and varnish factories (cohort study), for exposure to detergents, floor cleaning agents, or polish (case-control study) and with floor polishing or window cleaning (cohort study), and for exposure to refuse (case-control study) and work in refuse disposal plants (cohort study). PMID:3790458

Norell, S; Ahlbom, A; Olin, R; Erwald, R; Jacobson, G; Lindberg-Navier, I; Wiechel, K L

1986-11-01

266

Unity power factor switching regulator  

NASA Technical Reports Server (NTRS)

A single or multiphase boost chopper regulator operating with unity power factor, for use such as to charge a battery is comprised of a power section for converting single or multiphase line energy into recharge energy including a rectifier (10), one inductor (L.sub.1) and one chopper (Q.sub.1) for each chopper phase for presenting a load (battery) with a current output, and duty cycle control means (16) for each chopper to control the average inductor current over each period of the chopper, and a sensing and control section including means (20) for sensing at least one load parameter, means (22) for producing a current command signal as a function of said parameter, means (26) for producing a feedback signal as a function of said current command signal and the average rectifier voltage output over each period of the chopper, means (28) for sensing current through said inductor, means (18) for comparing said feedback signal with said sensed current to produce, in response to a difference, a control signal applied to the duty cycle control means, whereby the average inductor current is proportionate to the average rectifier voltage output over each period of the chopper, and instantaneous line current is thereby maintained proportionate to the instantaneous line voltage, thus achieving a unity power factor. The boost chopper is comprised of a plurality of converters connected in parallel and operated in staggered phase. For optimal harmonic suppression, the duty cycles of the switching converters are evenly spaced, and by negative coupling between pairs 180.degree. out-of-phase, peak currents through the switches can be reduced while reducing the inductor size and mass.

Rippel, Wally E. (Inventor)

1983-01-01

267

Comparing Factor Structures of Adolescent Psychopathology  

ERIC Educational Resources Information Center

Research on the structure of adolescent psychopathology can provide information on broad factors that underlie different forms of maladjustment in youths. Multiple studies from the literature on adult populations suggest that 2 factors, Internalizing and Externalizing, meaningfully comprise the factor structure of adult psychopathology (e.g.,…

Verona, Edelyn; Javdani, Shabnam; Sprague, Jenessa

2011-01-01

268

The impact factor of angewandte chemie …?.  

PubMed

What does the Impact Factor tell us? This question is addressed by Peter Glitz in his Editorial, particularly in light of the surprising drop in the 2013 Impact Factor of Angewandte Chemie. An explanation is sought and found. Most importantly the influence of the individual variables that determine the Impact Factor needs to be understood. PMID:25504900

Gölitz, Peter

2015-01-01

269

Human factors: a necessary tool for industry  

SciTech Connect

The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

Starcher, K.O.

1984-03-09

270

Hierarchical Factoring in a Standardized Achievement Battery.  

ERIC Educational Resources Information Center

The factorial validity of the Iowa Tests of Basic Skills was investigated. Hierarchical factor analysis was performed with a subset of the standardization data to explore the presence of second-order group factors. Results supported the construct validity of Language and Mathematics subscales. Verbal and Visual Information group factors were…

Martin, David J.; Dunbar, Stephen B.

1985-01-01

271

Continental Factors in International Real Estate Returns  

Microsoft Academic Search

This paper examines the extent to which real estate returns are driven by continental factors. This subject is relevant for determining the country allocation of international real estate portfolios. If returns are driven by a continental factor, investors should look for diversification opportunities outside their own continent. This paper finds strong continental factors in North America and especially in the

Piet Eichholtz; Ronald Huisman; Kees Koedijk; Lisa Schuin

1998-01-01

272

ESTIMATING UNCERTAINITIES IN FACTOR ANALYTIC MODELS  

EPA Science Inventory

When interpreting results from factor analytic models as used in receptor modeling, it is important to quantify the uncertainties in those results. For example, if the presence of a species on one of the factors is necessary to interpret the factor as originating from a certain ...

273

Human Factors Contributions to Knowledge Elicitation  

Microsoft Academic Search

Objective: The objective of this article is to lay out contributions of human factors to knowledge elicitation (KE) methodology. Background: The background is historical, dating to about 1985, and involves the convergence of expert systems with applied psychology and cognitive psychology. Method: The method is a literature review, focusing on past issues of Human Factors. Results: Human factors researchers have

Robert R. Hoffman

2008-01-01

274

EXPOSURE FACTORS HANDBOOK (1997 FINAL REPORT)  

EPA Science Inventory

The Exposure Factors Handbook provides a summary of the available statistical data on various factors used in assessing human exposure. This Handbook is addressed to exposure assessors inside the Agency as well as outside, who need to obtain data on standard factors to calculate ...

275

Factors Explaining Faculty Technology Use and Productivity  

ERIC Educational Resources Information Center

This study examines factors related to technology use in teaching by university faculty. An EFA analysis of multiple questions of technology use in the classroom found two factors: one loaded with Web use and the second with email use. Therefore, three research questions were asked: What factors explain faculty use of the Web or email? Are these…

Xu, Yonghong; Meyer, Katrina A.

2007-01-01

276

The Infinitesimal Jackknife with Exploratory Factor Analysis  

ERIC Educational Resources Information Center

The infinitesimal jackknife, a nonparametric method for estimating standard errors, has been used to obtain standard error estimates in covariance structure analysis. In this article, we adapt it for obtaining standard errors for rotated factor loadings and factor correlations in exploratory factor analysis with sample correlation matrices. Both…

Zhang, Guangjian; Preacher, Kristopher J.; Jennrich, Robert I.

2012-01-01

277

40 CFR 227.15 - Factors considered.  

Code of Federal Regulations, 2010 CFR

... 2010-07-01 false Factors considered. 227.15 Section...Ocean Dumping § 227.15 Factors considered. The need for...evaluation of the following factors: (a) Degree of treatment...relative environmental risks, impact and cost for ocean...

2010-07-01

278

Journal influence factors6 Massimo Franceschet  

E-print Network

Journal influence factors6 Massimo Franceschet Department of Mathematics and Computer Science of journal influence, namely 2- year impact factor, 5-year impact factor, eigenfactor and article influence. These indicators have been recently added by Thomson Reuters to the Journal Citation Reports, in both science

Franceschet, Massimo

279

Rainbow H-factors Raphael Yuster  

E-print Network

Rainbow H-factors Raphael Yuster Department of Mathematics University of Haifa, Haifa 31905, Israel, a rainbow H-subgraph of G is an H-subgraph of G whose edges have distinct colors. A rainbow H-factor is an H-factor whose components are rainbow H-subgraphs. The follow- ing result is proved. If H is any fixed graph

Yuster, Raphael

280

Genetic Factors in Drug Abuse and Dependence  

Microsoft Academic Search

STATEMENT OF THE PROBLEM The etiology of drug abuse\\/dependence is a complex interplay of psychosocial and biological factors. These factors include socioeconomic status, education, drug availability, peer pressure, childhood and adult comorbid psychiatric disorders, and specific mutant genes. The emphasis of this chapter is on the role that genetic factors play in an individual's vulnerability to drug abuse\\/dependence, henceforth simply

David E. Comings

281

Human Factors Engineering Standards at NASA  

NASA Technical Reports Server (NTRS)

NASA has begun a new approach to human factors design standards. For years NASA-STD-3000, Manned Systems Integration Standards, has been a source of human factors design guidance for space systems. In order to better meet the needs of the system developers, NASA is revising its human factors standards system. NASA-STD-3000 will be replaced by two documents: set of broad human systems design standards (including both human factors and medical topics) and a human factors design handbook. At the present time the standards document is in final review with some disagreement on several critical issues. The handbook is progressing with November 2008 as the anticipated completion date.

Russo, Dane; Tillman, Barry; Pickett, Lynn

2008-01-01

282

Growth Factors in Proliferative Diabetic Retinopathy  

PubMed Central

Many growth factors are implicated in the pathogenesis of proliferative diabetic retinopathy. Alteration of growth factors and their receptors in diabetes has been shown in both experimental and clinical studies. Sustained hyperglycemia resulting from long-standing diabetes leads to several biochemical abnormalities that consequently result in retinal hypoxia. Retinal oxygenation state regulates various growth factors that promote angiogenesis in order to meet the oxygen demands of the tissue. However, unregulated expression of these growth factors and induction of complex cascades leading to augmentation of other proangiogenic factors, which may not be regulated by tissue oxygenation, leads to uncontrolled retinal neovascularization and blindness in diabetic patients. PMID:14668050

Khan, Zia Ali

2003-01-01

283

Uncertainty of the tritium dose conversion factor.  

PubMed

Environmental releases of tritium oxide at a number of Department of Energy nuclear weapons facilities contribute to a significant portion of environmental dose. Several conversion factors are utilized in the estimation of human impact from these releases, e.g., dispersion coefficients, consumption rates, uptake factors, transport factors, dose conversion factors, and risk coefficients. A probabilistic determination of the tritium dose conversion factor was generated in this work to assess the uncertainty of the internal dosimetry required to estimate dose equivalent given an intake of tritium oxide. The tritium dose conversion factor was found to vary by a factor of about 15 with a median value of 2.2 x 10(-11) Sv Bq(-1) when considering orthovoltage x rays as the standard for estimating the relative biological effectiveness of tritium. The median dose conversion factor increases by about 50%; however, when gamma radiation is considered as the standard. The current deterministic estimate of the tritium dose conversion factor published by the DOE and the EPA is 1.7 x 10(-11) Sv Bq(-1), 25-50% lower than the median probabilistic values. The tritium oxide dose conversion factor model was found to be most sensitive to biological half-life and quality factor and is highly dependent on the standardizing radiation for RBE assessments. PMID:10456500

Hamby, D M

1999-09-01

284

Optimizing neurotrophic factor combinations for neurite outgrowth  

NASA Astrophysics Data System (ADS)

Most neurotrophic factors are members of one of three families: the neurotrophins, the glial cell-line derived neurotrophic factor family ligands (GFLs) and the neuropoietic cytokines. Each family activates distinct but overlapping cellular pathways. Several studies have shown additive or synergistic interactions between neurotrophic factors from different families, though generally only a single combination has been studied. Because of possible interactions between the neurotrophic factors, the optimum concentration of a factor in a mixture may differ from the optimum when applied individually. Additionally, the effect of combinations of neurotrophic factors from each of the three families on neurite extension is unclear. This study examines the effects of several combinations of the neurotrophin nerve growth factor (NGF), the GFL glial cell-line derived neurotrophic factor (GDNF) and the neuropoietic cytokine ciliary neurotrophic factor (CNTF) on neurite outgrowth from young rat dorsal root ganglion (DRG) explants. The combination of 50 ng ml-1 NGF and 10 ng ml-1 of each GDNF and CNTF induced the highest level of neurite outgrowth at a 752 ± 53% increase over untreated DRGs and increased the longest neurite length to 2031 ± 97 µm compared to 916 ± 64 µm for untreated DRGs. The optimum concentrations of the three factors applied in combination corresponded to the optimum concentration of each factor when applied individually. These results indicate that the efficacy of future therapies for nerve repair would be enhanced by the controlled release of a combination of neurotrophins, GFLs and neuropoietic cytokines at higher concentrations than used in previous conduit designs.

Deister, C.; Schmidt, C. E.

2006-06-01

285

Factor tree (grades 6-8)  

NSDL National Science Digital Library

This virtual manipulative challenges the learner to find the prime factors for a pair of numbers. The factors for each number are displayed in a tree diagram from which the student drags the factors to the appropriate areas of a Venn diagram. The Venn diagram offers a useful visual display showing unique factors and common factors for the original pair of numbers. Using the display, the learner must find the pair's least common multiple (LCM) and greatest common factor (GCF). Buttons allow users to check their answers and select new problems. Instructions for using the manipulative are included, along with information about factoring. The site also links to the NCTM standard for number and operations. Copyright 2005 Eisenhower National Clearinghouse

Mathematics, Utah S.

2003-01-01

286

Factors that regulate embryonic gustatory development  

PubMed Central

Numerous molecular factors orchestrate the development of the peripheral taste system. The unique anatomy/function of the taste system makes this system ideal for understanding the mechanisms by which these factors function; yet the taste system is underutilized for this role. This review focuses on some of the many factors that are known to regulate gustatory development, and discusses a few topics where more work is needed. Some attention is given to factors that regulate epibranchial placode formation, since gustatory neurons are thought to be primarily derived from this region. Epibranchial placodes appear to arise from a pan-placodal region and a number of regulatory factors control the differentiation of individual placodes. Gustatory neuron differentiation is regulated by a series of transcription factors and perhaps bone morphongenic proteins (BMP). As neurons differentiate, they also proliferate such that their numbers exceed those in the adult, and this is followed by developmental death. Some of these cell-cycling events are regulated by neurotrophins. After gustatory neurons become post-mitotic, axon outgrowth occurs. Axons are guided by multiple chemoattractive and chemorepulsive factors, including semaphorins, to the tongue epithelium. Brain derived neurotrophic factor (BDNF), functions as a targeting factor in the final stages of axon guidance and is required for gustatory axons to find and innervate taste epithelium. Numerous factors are involved in the development of gustatory papillae including Sox-2, Sonic hedge hog and Wnt-?-catenin signaling. It is likely that just as many factors regulate taste bud differentiation; however, these factors have not yet been identified. Studies examining the molecular factors that regulate terminal field formation in the nucleus of the solitary tract are also lacking. However, it is possible that some of the factors that regulate geniculate ganglion development, outgrowth, guidance and targeting of peripheral axons may have the same functions in the gustatory CNS. PMID:17903280

Krimm, Robin F

2007-01-01

287

On the Likelihood Ratio Test for the Number of Factors in Exploratory Factor Analysis  

ERIC Educational Resources Information Center

In the exploratory factor analysis, when the number of factors exceeds the true number of factors, the likelihood ratio test statistic no longer follows the chi-square distribution due to a problem of rank deficiency and nonidentifiability of model parameters. As a result, decisions regarding the number of factors may be incorrect. Several…

Hayashi, Kentaro; Bentler, Peter M.; Yuan, Ke-Hai

2007-01-01

288

Activation of Factor XII by Dextran Sulfate: The Basis for an Assay of Factor XII  

Microsoft Academic Search

A system was developed for studying the activation of factor XII (Hageman factor) in the presence .gf dextran sulfate (DS). Salient features of the system included low ionic strength (0.08). low concentration of factor XII (ap- proximately 1 I 10.000 that in normal plasma), and an excess of exogenous prekallikrein (PK). In this system, factor XII was rapidly converted to

Donald L. Tankersley; Barbara M. Alving; J. S. Finlayson

1983-01-01

289

Factor models for relational data Real-world network sampling Mostly factor models  

E-print Network

Factor models for relational data Real-world network sampling Mostly factor models Peter Hoff(yi,j = 1|opposite sex) = 0.056 #12;Factor models for relational data Real-world network sampling p(~Y|Y, X) #12;Factor models for relational data Real-world network sampling Model fit glm

Hoff, Peter

290

Factors fragmenting the Russian Federation  

SciTech Connect

This paper examines the factors that threaten the future of the Russian Federation (RF). The observations are based on a study that focused on eight republics: Mordova, Udmurtia, Tatarstan, Mari El, Bashkortostan, Kabardino-Balkaria, Buryatia, and Altay Republic. These republics were selected for their geographic and economic significance to the RF. Tatarstan, Bashkortostan, Udmurtia, and Mari El are located on important supply routes, such as the Volga River and the trans-Siberian railroad. Some of these republics are relatively wealthy, with natural resources such as oil (e.g., Tatarstan and Bashkortostan), and all eight republics play significant roles in the military-industrial complex. The importance of these republics to the RF contrasts to the relative insignificance of the independence-minded Northern Caucasus area. The author chose not to examine the Northern Caucasus region (except Kabardino-Balkaria) because these republics may have only a minor impact on the rest of the RF if they secede. Their impact would be minimized because they lie on the frontiers of the RF. Many Russians believe that {open_quotes}it might be best to let such a troublesome area secede.{close_quotes}

Brown, E.

1993-10-06

291

Interaction of factor XIII subunits.  

PubMed

Coagulation factor XIII (FXIII) is a heterotetramer consisting of 2 catalytic A subunits (FXIII-A2) and 2 protective/inhibitory B subunits (FXIII-B2). FXIII-B, a mosaic protein consisting of 10 sushi domains, significantly prolongs the lifespan of catalytic subunits in the circulation and prevents their slow progressive activation in plasmatic conditions. In this study, the biochemistry of the interaction between the 2 FXIII subunits was investigated. Using a surface plasmon resonance technique and an enzyme-linked immunosorbent assay-type binding assay, the equilibrium dissociation constant (Kd) for the interaction was established in the range of 10(-10) M. Based on the measured Kd, it was calculated that in plasma approximately 1% of FXIII-A2 should be in free form. This value was confirmed experimentally by measuring FXIII-A2 in plasma samples immunodepleted of FXIII-A2B2. Free plasma FXIII-A2 is functionally active, and when activated by thrombin and Ca(2+), it can cross-link fibrin. In cerebrospinal fluid and tears with much lower FXIII subunit concentrations, >80% of FXIII-A2 existed in free form. A monoclonal anti-FXIII-B antibody that prevented the interaction between the 2 subunits reacted with the recombinant combined first and second sushi domains of FXIII-B, and its epitope was localized to the peptide spanning positions 96 to 103 in the second sushi domain. PMID:24408323

Katona, Eva; Pénzes, Krisztina; Csapó, Andrea; Fazakas, Ferenc; Udvardy, Miklós L; Bagoly, Zsuzsa; Orosz, Zsuzsanna Z; Muszbek, László

2014-03-13

292

FACTORS CONTROLLING SERUM ?-GLOBULIN CONCENTRATION  

PubMed Central

Both synthetic and catabolic processes determine the serum ?-globulin level. The rate of ?-globulin synthesis appears to be the primary factor determining the amount of serum ?-globulin. Increase of ?-globulin synthesis (as may occur following immunization or development of plasma cell tumor) elevates the serum ?-globulin level. This, in turn, accelerates the fractional rate of ?-globulin catabolism. The change in catabolic rate reduces the dimensions of the serum change from that which would occur if synthesis alone determined the serum ?-globulin level. The present studies indicate the existence of a homeostatic mechanism controlling the rate of ?-globulin catabolism. The mechanisms of ?-globulin catabolism are specific and selective. Marked serum increase of other immunoglobulin components (?2A-globulins and ?1-macroglobulins) do not accelerate ?-globulin catabolism. Similarly, serum albumin increases do not influence ?-globulin catabolism. The site determining ?-globulin catabolism is restricted to a part of the ?-globulin molecule; i.e., on the F piece obtained by papain digestion and, by inference, on the H chains obtained by reduction and alkylation of ?-globulin molecules. PMID:14087625

Fahey, John L.; Robinson, Alan G.

1963-01-01

293

Spinach protein factor and chlorophyllase.  

PubMed

1. Spinach leaves contain a "Spinach Protein Factor" (SPF) which increases light sensitivity of colloidal chlorophylls in aqueous solution (Terpstra, 1967). SPF activity, measured in different fractions of spinach-leaf acetone-powder extracts obtained by gel filtration on DEAE- and CM-Sephadex, runs parallel with chlorophyllase activity. The same positive correlation is generally observed in aqueous extracts of certain small particles isolated from spinach-leaf homogenates. It is suggested that SPF is a chlorophyllase. 2. Another, less active chlorophyllase was found in endive leaves. Evidence is presented that this chlorophyllase competes with the more active SPF chlorophyllase for available (bacterio)chlorophyll. The less active chlorophyllase is also present, in varying amounts, in spinach leaves. 3. SPF activity and chlorophyllase activity are influenced by phosphate in different concentrations in a similar way. 4. Both the SPF chlorophyllase and the less active chlorophyllase accelerate the conversion of colloidal bacteriochlorophyll from a form with red absorption bands at about 845 and 790 nm into a form with a main red band at about 775 nm; besides, the chlorophyllases cause the 775 nm band to be shifted to shorter wavelength (770-766 nm). The conversion by the less active chlorophyllase is inhibited by Ca(2+) (0.01 M). Light sensitivity of the 770-766-nm bacteriochlorophyll form is enhanced by the SPF chlorophyllase, but not by the less active chlorophyllase. PMID:24473911

Terpstra, W; Weijman, A C

1972-12-01

294

Nutritional factors and thalassaemia major.  

PubMed Central

Abnormal growth is a common feature of thalassaemia major in children. In an attempt to determine whether it has a nutritional cause, 12 children aged 1 to 3 years with thalassaemia major were studied under metabolic ward conditions. Nutritional status was assessed by anthropometry and biochemistry before and after an intensive nutrition regimen. Five children had wasting or stunting on admission. As a result of the nutrition intervention, mean weight for height improved significantly. The mean height increase of 0.4 cm after one month was not significant. Plasma zinc, depressed in half the children on admission, improved, as did alpha tocopherol, while copper decreased. Plasma insulin-like growth factor-I also increased commensurate with improved growth. Fat absorption was normal in all children. Undernutrition is an important cause of associated growth disturbances in children with thalassaemia major. Malnutrition was primarily caused by inadequate nutrient intake, as indicated by the capacity to gain weight appropriately when provided with nutrition support, and by the absence of intestinal malabsorption. While long term studies are required to determine if nutritional support will prevent stunting, these results underscore its central role in preventing nutritional deficiencies and in promoting normal growth in thalassaemic children. PMID:8787427

Fuchs, G J; Tienboon, P; Linpisarn, S; Nimsakul, S; Leelapat, P; Tovanabutra, S; Tubtong, V; DeWier, M; Suskind, R M

1996-01-01

295

Human factors in agile manufacturing  

SciTech Connect

As industries position themselves for the competitive markets of today, and the increasingly competitive global markets of the 21st century, agility, or the ability to rapidly develop and produce new products, represents a common trend. Agility manifests itself in many different forms, with the agile manufacturing paradigm proposed by the Iacocca Institute offering a generally accepted, long-term vision. In its many forms, common elements of agility or agile manufacturing include: changes in business, engineering and production practices, seamless information flow from design through production, integration of computer and information technologies into all facets of the product development and production process, application of communications technologies to enable collaborative work between geographically dispersed product development team members and introduction of flexible automation of production processes. Industry has rarely experienced as dramatic an infusion of new technologies or as extensive a change in culture and work practices. Human factors will not only play a vital role in accomplishing the technical and social objectives of agile manufacturing. but has an opportunity to participate in shaping the evolution of industry paradigms for the 21st century.

Forsythe, C.

1995-03-01

296

Factors affecting reciprocating compressor performance  

SciTech Connect

A reciprocating compressor is a positive displacement machine and, in principal, its capacity and horsepower can be calculated very easily. In practice, however, several loss mechanisms act to decrease capacity and increase horsepower from the ideal predicted values. Many of these effects are quite difficult to predict accurately and the only effective way of developing reciprocating compressor performance prediction methods is to run a large number of tests on different compressors under different operating conditions. Combined with an understanding of the physics controlling the losses, experimental results allow good empirical models of losses to be developed. However, without the benefit of a good understanding of the physics of the loss mechanisms, it is impossible to interpret test results. Some factors affecting the magnitude of losses are compressor design, compressor speed, suction and discharge pressure and temperature, gas composition, suction and discharge piping design, and valve design. Losses that are important in some applications may be negligible in others so it is essential that a wide range of compressor designs, valve designs, gas molecular weight and operating conditions be tested when developing a performance prediction model. The paper discusses the effects of clearance and pressure ratio; the primary losses affecting capacity and power, including valve and port pressure loss, valve springing, valve inertia, piston ring leakage, packing leakage, discharge valve leakage, suction valve leakage, pulsations, heat transfer in the suction passage, and heat transfer in the cylinder; heat transfer in compressor cylinders; performance prediction methods; and compressor diagnosis.

Woollatt, D. (Dresser-Rand Co., Painted Post, NY (United States))

1993-06-01

297

Environmental factors in Tourette syndrome.  

PubMed

Environmental exposures during the prenatal period, perinatal stages, and postnatal life may contribute to onset and course of Tourette syndrome (TS). Pregnancy-related noxious exposures may be more frequent in pregnancies of children who will develop TS, particularly maternal smoking and prenatal life stressors. Lower birth weight and use of forceps at delivery may be associated with tic severity in the offspring; moreover, low birth weight and maternal smoking during pregnancy may affect the risk of co-morbid attention-deficit/hyperactivity and obsessive-compulsive disorders. Group A streptococcal infections as risk-modifier for TS has not been convincingly demonstrated to date, although an interaction with stressors was suggested. The PANDAS hypothesis is currently undergoing a nosological revision. Only limited anecdotal evidence supports a link of TS to other pathogens. Nevertheless, the relationship between infections and TS may be complex. Recent data point to intrinsically altered immune regulation in TS, which might predispose to both infections and autoimmune mechanisms; however, evidence of cell-mediated and antibody-mediated autoimmunity in TS is still insufficient. Psychosocial stress remains the most important contextual factor influencing tic severity, as confirmed by prospective studies. This might in part be related to enhanced reactivity of the stress response in TS patients, the mechanisms of which need to be explored further. New studies on large prospective cohorts of patients of different age and the identification of reliable biomarkers or endophenotypes indicating early, prenatal exposure to environmental insults are needed. PMID:23092654

Hoekstra, Pieter J; Dietrich, Andrea; Edwards, Mark J; Elamin, Ishraga; Martino, Davide

2013-07-01

298

Materiales compuestos C\\/SiC para aplicaciones estructurales de alta temperatura. Parte I: estabilidad termodinámica y química  

Microsoft Academic Search

The development of aero-engine and aircraft industry is aimed to hypersonic technology, efficiency enhancements and pollutant emission reductions. This objective can only be reached by increasing the operating temperatures, utilising new materials which mechanical properties are retained up to high temperatures. SiC matrix composites reinforced with carbon fibres (C\\/SiC) are good examples with very good ben- ding and thermal shock

M. APARICIO; A. dURÁN

299

Roles for Growth Factors in Cancer Progression  

NSDL National Science Digital Library

Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy.

Esther Witsch (Weizmann Institute of Science); Michael Sela (Weizmann Institute of Science); Yosef Yarden (The Weizmann Institute of Science)

2010-04-01

300

The Q-factor of flexure membranes  

NASA Astrophysics Data System (ADS)

We report on the intrinsic or material quality factor (Q-factor) of a number of different materials, possible suited for the construction of low loss flexures. Clamped foil flexure membranes made from titanium, a glassy alloy, Cusil and Havar (high strength non-magnetic alloy), as well as monolithic flexure membranes made from titanium, niobium and Marval 18 (maraging) steel, have been tested. The results show that the highest intrinsic Q-factor occurs for monolithic flexure membranes constructed from niobium, with maraging steel also yielding a high intrinsic Q-factor. Other materials tested were shown to be significantly inferior. For a pendulum of mass 10 kg, with a stress safety factor of ? = 0.3, we predict a maximum Q-factor of 3.1×107 for a niobium flexure, and 2.9×106 for a maraging steel flexure.

Baker, M.; Ju, L.; Blair, D. G.

2001-10-01

301

Development of an Integrated Human Factors Toolkit  

NASA Technical Reports Server (NTRS)

An effective integration of human abilities and limitations is crucial to the success of all NASA missions. The Integrated Human Factors Toolkit facilitates this integration by assisting system designers and analysts to select the human factors tools that are most appropriate for the needs of each project. The HF Toolkit contains information about a broad variety of human factors tools addressing human requirements in the physical, information processing and human reliability domains. Analysis of each tool includes consideration of the most appropriate design stage, the amount of expertise in human factors that is required, the amount of experience with the tool and the target job tasks that are needed, and other factors that are critical for successful use of the tool. The benefits of the Toolkit include improved safety, reliability and effectiveness of NASA systems throughout the agency. This report outlines the initial stages of development for the Integrated Human Factors Toolkit.

Resnick, Marc L.

2003-01-01

302

Roles for Growth Factors in Cancer Progression  

PubMed Central

Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy. PMID:20430953

Witsch, Esther; Sela, Michael; Yarden, Yosef

2011-01-01

303

Transcriptional factors, Mafs and their biological roles  

PubMed Central

The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs.

Tsuchiya, Mariko; Misaka, Ryoichi; Nitta, Kosaku; Tsuchiya, Ken

2015-01-01

304

Transcriptional factors, Mafs and their biological roles.  

PubMed

The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs. PMID:25685288

Tsuchiya, Mariko; Misaka, Ryoichi; Nitta, Kosaku; Tsuchiya, Ken

2015-02-15

305

Factorization of the tenth Fermat number  

Microsoft Academic Search

We describe the complete factorization of the tenth Fermat num- ber F10 by the elliptic curve method (ECM). F10 is a product of four prime factors with 8, 10, 40 and 252 decimal digits. The 40-digit factor was found after about 140 Mflop-years of computation. We also discuss the complete fac- torization of other Fermat numbers by ECM, and summarize

Richard P. Brent

1999-01-01

306

The factors during protein crystallization: A review  

NASA Astrophysics Data System (ADS)

Many factors have effects on crystallization. The major influencing factors during protein crystallization are summarized in this paper. Recommendations are made about the basic process of crystallization and the analysis of the thermodynamic effects on crystallization, and the dynamics factors effecting crystallization during an equilibrium process are discussed. The advantages of ionic liquid in various chemical processes, especially in the field of biochemistry, are emphasized, and some tentative conclusions are made about future short-term trends.

Li, X. X.; Xu, X. D.; Dan, Y. Y.; Zhang, M. L.

2008-12-01

307

Environmental Factors in the Polycystic Ovary Syndrome  

Microsoft Academic Search

Polycystic ovary syndrome (PCOS) is a prevalent disorder that is still not well understood. Genetic predisposition is important,\\u000a but neonatal, prepubertal, pubertal, and postpubertal factors participate in its clinical expression. In this chapter we will\\u000a review these factors and the evidence that supports causal association with the development of PCOS. Unfortunately, little\\u000a evidence exists for many of these factors. Obesity

Marie-France Hivert; Jean-Patrice Baillargeon

308

Factors affecting the lipase activity of milk  

E-print Network

FACTORS AFFECTING THE LIPASE ACTIVITY OF MILK A Thesis By PAUL THOMAS TALLAMY Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE January 1969 Major... Subject: Food Technology FACTORS AFFECTING THE LIPASE ACTIVITY OF MILK A Thesis By PAUL THOMAS TALLAMY Approved as to style and content by: Chairman of Commi tee fg M ber Head f Depar tmen Mem er Member January 1969 ABSTRACT Factors Affecting...

Tallamy, Paul Thomas

1969-01-01

309

Human Factors Considerations in System Design  

NASA Technical Reports Server (NTRS)

Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined. The following topics are discussed: human factors aspects of control room design; design of interactive systems; human computer dialogue, interaction tasks and techniques; guidelines on ergonomic aspects of control rooms and highly automated environments; system engineering for control by humans; conceptual models of information processing; information display and interaction in real time environments.

Mitchell, C. M. (editor); Vanbalen, P. M. (editor); Moe, K. L. (editor)

1983-01-01

310

Create Prime Factorization Trees with Little Alchemy  

NSDL National Science Digital Library

This lesson plan provides steps for using the open sandbox game Little Alchemy to teach Prime Factorization Trees. Little Alchemy is available as a free download or it can be opened in a webpage. The lesson plans includes a 3-minute video on how to create elements using the game. In addition to students making factor trees they can extend this lesson to write prime factorization in exponential form.

Molfino, Agustin

2013-04-16

311

Human factors and safety in emergency medicine  

NASA Technical Reports Server (NTRS)

A model based on an input process and outcome conceptualisation is suggested to address safety-relevant factors in emergency medicine. As shown in other dynamic and demanding environments, human factors play a decisive role in attaining high quality service. Attitudes held by health-care providers, organisational shells and work-cultural parameters determine communication, conflict resolution and workload distribution within and between teams. These factors should be taken into account to improve outcomes such as operational integrity, job satisfaction and morale.

Schaefer, H. G.; Helmreich, R. L.; Scheidegger, D.

1994-01-01

312

Design and Synthesis of Binding Growth Factors  

PubMed Central

Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches. PMID:22754349

Tada, Seiichi; Kitajima, Takashi; Ito, Yoshihiro

2012-01-01

313

Factors associated with urinary incontinence in women.  

PubMed Central

Possible aetiological factors for urinary incontinence were examined in a prevalence study among a random sample of 1000 women aged 18 and over. Infective factors were not markedly associated with incontinence but mechanical factors such as parity and obesity were. No association was found, however, between a history of perineal damage at childbirth and incontinence. Women with incontinence had on average a higher score for a 'neuroticism' trait elicited by questionnaire than women without the disorder. PMID:7069357

Yarnell, J W; Voyle, G J; Sweetnam, P M; Milbank, J; Richards, C J; Stephenson, T P

1982-01-01

314

Emission Factors of Cement Industry in Turkey  

Microsoft Academic Search

PM, SO2, NO2 and CO emissions were measured by Turkish Cement Manufacturers' Association (TCMA) in cement plants by using standard techniques and equipment since 1997.Emission factors (EF) were calculated by using these availabledata for the cement sector. The emission factors were found bothfor cement and grinding-packing plants separately. The results of the study were compared with international emission factors.It was

Baris R. Canpolat; Aysel T. Atimtay; Ismet Munlafalioglu; Ersan Kalafatoglu; Ekrem Ekinci

2002-01-01

315

Risk Factors for Voice Problems in Teachers  

Microsoft Academic Search

In order to identify factors that are associated with voice problems and voice-related absenteeism in teachers, 1,878 questionnaires were analysed. The questionnaires inquired about personal data, voice complaints, voice-related absenteeism from work and conditions that may lead to voice complaints and absenteeism. Different factors play a role in the development and consolidation of voice problems. Physical and psycho-emotional factors appear

P. G. C. Kooijman; F. I. C. R. S. de Jong; G. Thomas; W. J. Huinck; R. Donders; K. Graamans; H. K. Schutte

2006-01-01

316

Factor VIII inhibitor associated with peginterferon.  

PubMed

We present a case of a 53-year-old black male who developed a factor VIII inhibitor during his treatment for hepatitis C virus infection with peginterferon. The development of inhibitors against factor VIII during peginterferon therapy has been rarely reported. We have reviewed the current literature and the following case presentation provides the first demonstration, to our knowledge, in which chronic exposure to peginterferon is associated with an acquired factor VIII inhibitor. PMID:16011596

Herman, C; Boggio, L; Green, D

2005-07-01

317

Therapeutic Alliance and Common Factors in Treatment  

Microsoft Academic Search

\\u000a Changes in therapy can result from variables unique to a particular treatment package (i.e., specific factors), as a function\\u000a of variables common to a variety of treatments (i.e., nonspecific\\/common factors), or a combination of both specific and nonspecific\\u000a ingredients (Kazdin,1979). Nonspecific (or common) treatment factors include variables that are common across different treatment\\u000a modalities, which are thought to influence outcomes

Daniella M. Halperin; Meara L. Weitzman; Michael W. Otto

318

Investigating the factors influencing RDX shock sensitivity.  

E-print Network

??The shock sensitivity of RDX (cyclotrimethylenetrinitramine) is dependent upon factors including crystal size, morphology, internal defects, surface defects and HMX content. With the arrival of… (more)

Hudson, R J

319

How is impact factor impacting our research?  

PubMed

The impact factor (IF) of an journal is a measure reflecting the average number of citations to recent articles published in the journal. It is frequently used as a proxy for the relative importance of a journal within its field, with journals with higher impact factors deemed to be more important than those with lower ones. However it is not a perfect metric and has its own limitations. Journals are increasingly finding new ways to improve their impact factor by increasing self citation, publishing more review articles. This correspondence discuss the fallacies of the impact factor. PMID:25179695

Rawat, Seema

2014-01-01

320

Soliton form factors from lattice simulations  

E-print Network

The form factor provides a convenient way to describe properties of topological solitons in the full quantum theory, when semiclassical concepts are not applicable. It is demonstrated that the form factor can be calculated numerically using lattice Monte Carlo simulations. The approach is very general and can be applied to essentially any type of soliton. The technique is illustrated by calculating the kink form factor near the critical point in 1+1-dimensional scalar field theory. As expected from universality arguments, the result agrees with the exactly calculable scaling form factor of the two-dimensional Ising model.

Arttu Rajantie; David J. Weir

2011-01-06

321

Factors Contributing to Crashes among Young Drivers  

PubMed Central

Young drivers are the group of drivers most likely to crash. There are a number of factors that contribute to the high crash risk experienced by these drivers. While some of these factors are intrinsic to the young driver, such as their age, gender or driving skill, others relate to social factors and when and how often they drive. This article reviews the factors that affect the risk of young drivers crashing to enable a fuller understanding of why this risk is so high in order to assist in developing effective countermeasures. PMID:25097763

Bates, Lyndel J.; Davey, Jeremy; Watson, Barry; King, Mark J.; Armstrong, Kerry

2014-01-01

322

Matrix factorization on a hypercube multiprocessor  

SciTech Connect

This paper is concerned with parallel algorithms for matrix factorization on distributed-memory, message-passing multiprocessors, with special emphasis on the hypercube. Both Cholesky factorization of symmetric positive definite matrices and LU factorization of nonsymmetric matrices using partial pivoting are considered. The use of the resulting triangular factors to solve systems of linear equations by forward and back substitutions is also considered. Efficiencies of various parallel computational approaches are compared in terms of empirical results obtained on an Intel iPSC hypercube. 19 refs., 6 figs., 2 tabs.

Geist, G.A.; Heath, M.T.

1985-08-01

323

NASA Information Sciences and Human Factors Program  

NASA Technical Reports Server (NTRS)

Fiscal year 1989 descriptions of technical accomplishments in seven sections are presented: automation and robotics; communications; computer sciences; controls and guidance; data systems; human factors; and sensor technology.

Holcomb, Lee; Hood, Ray; Montemerlo, Melvin; Jenkins, James; Smith, Paul; Dibattista, John; Depaula, Ramon; Hunter, Paul

1990-01-01

324

NASA information sciences and human factors program  

NASA Technical Reports Server (NTRS)

The FY-90 descriptions of technical accomplishments are contained in seven sections: Automation and Robotics, Communications, Computer Sciences, Controls and Guidance, Data Systems, Human Factors, and Sensor Technology.

Holcomb, Lee; Hood, Ray; Montemerlo, Melvin; Jenkins, James; Smith, Paul; Dibattista, John; Depaula, Ramon; Hunter, Paul; Lavery, David

1991-01-01

325

NASA Information Sciences and Human Factors Program  

NASA Technical Reports Server (NTRS)

This report contains FY 1984/85 descriptions and accomplishments in six sections: Computer Science and Automation, Controls and Guidance, Data Systems, Human Factors, Sensor Technology, and Communications.

Holcomb, Lee B.; Mciver, Duncan E.; Dibattista, John D.; Larsen, Ronald L.; Montemerlo, Melvin D.; Wallgren, Ken; Sokoloski, Marty; Wasicko, Dick

1985-01-01

326

Thymic output: influence factors and molecular mechanism.  

PubMed

Thymus is a primary lymphoid organ, able to generate mature T cells that eventually colonize secondary lymphoid organs, and is therefore essential for peripheral T cell renewal. Recent data showed that normal thymocyte export can be altered by several influence factors including several chemokines, sphingosine1-phosphate (S1P), transcription factors such as Foxj1, Kruppel-like transcription factor 2 (KLF2) and antigen stimulation, etc. In this review, we summarized the recent reports about study strategies, influence factors and possible molecular mechanisms in thymic output. PMID:17092431

Jin, Rong; Zhang, Jun; Chen, Weifeng

2006-10-01

327

Factors affecting ostrich egg hatchability.  

PubMed

Ostrich eggs often have low hatchability (HATCH) rates because they do not lose sufficient weight during incubation. Because egg size, eggshell porosity and thickness (THICK), and length of preincubation egg storage are known to affect egg weight loss during incubation (EWL) and HATCH of chicken eggs, these factors were examined using ostrich eggs. The effects of eggshell porosity (number of large pores per cm2 of shell; LP); and THICK on EWL and HATCH were assessed by categorizing the eggs as having either low, intermediate, or high LP or low, intermediate, or high THICK. Mean EWL was higher (P<0.05) in eggs of the high LP group when compared with eggs in either the low or intermediate LP groups that lost similar amounts of weight during incubation. Mean HATCH was also higher (more than 25%; P<0.10) in eggs with high LP when compared with the HATCH found in eggs having low LP. Eggs from the intermediate LP group had an intermediate HATCH response. Moreover, numbers of LP were positively correlated to both EWL (r2 = 0.64; P<0.0001) and HATCH (r2 = 0.25; P<0.03). Inverse relationships existed between THICK and EWL and between THICK and HATCH according to the order (P< 0.05): eggs of low THICK, highest mean EWL and HATCH > eggs of intermediate THICK, intermediate mean EWL and HATCH > eggs of highest THICK, lowest mean EWL and HATCH. Shell thickness was not correlated to either EWL or HATCH. The influence of egg size on mean LP, THICK, EWL, HATCH, and chick weight (CWT) was assessed. Although THICK was unaffected by egg size, higher LP (P<0.10), EWL (P<0.05), and HATCH (P<0.10) were found in medium-sized eggs when compared with either small or large eggs. The CWT was associated with egg size (P<0.05) according to the order: large eggs, highest CWT > medium eggs, intermediate CWT > small eggs, lowest CWT. Neither EWL nor HATCH was affected by length of preincubation egg storage. Collectively, our findings suggest that 1) ostrich eggs that possess low LP and increased THICK hatched poorly, 2) intermediate-sized eggs hatch best, 3) large eggs produced large chicks, and 4) ostrich eggs can be stored under conditions typically used in the poultry industry for a minimum of 10 d without negatively impacting HATCH. PMID:10515354

Gonzalez, A; Satterlee, D G; Moharer, F; Cadd, G G

1999-09-01

328

Connective tissue growth factor in pterygium: simultaneous presence with vascular endothelial growth factor - possible contributing factor to conjunctival scarring  

Microsoft Academic Search

Background. Various growth factors have been detected in pterygium and been associated with its vasculogenesis. The basic pathophysiological mechanisms responsible especially for the fibrotic activity in pterygium are, however, not yet known. Connective tissue growth factor (CTGF) has been shown to be substantially involved in various processes of fibrosis. We report on the presence of CTGF in pterygium and its

Gysbert van Setten; Miltos Aspiotis; Timothy D. Blalock; Gary Grotendorst; Gregory Schultz

2003-01-01

329

Mitogenic effects of coagulation factor XII and factor XIIa on HepG2 cells.  

PubMed Central

The structure of coagulation factor XII (Hageman factor), inferred from its DNA sequence, includes two epidermal growth factor (EGF)-homologous domains in its amino-terminal region. This suggests that factor XII may exhibit EGF-like activities. Reciprocal antigenic cross-reactivity between factor XII and EGF was shown by exposing purified human factor XII or mouse EGF to anti-mouse EGF or anti-human factor XII. Western blot analysis showed that anti-mouse EGF recognized intact factor XII at 80 kDa. Together, these results suggest that the EGF-homologous domains are accessible for anti-EGF binding in native factor XII. To determine whether factor XII has mitogenic activity, HepG2 or L cells (10(4) cells per well) were grown in serum-free medium in the presence or absence of factor XII or kaolin-activated factor XII (factor XIIa). Both factors XII and XIIa (6.0 micrograms/ml) enhanced cell proliferation by approximately 2-fold (P less than 0.001 and P less than 0.005, respectively). In contrast, L cells, which are not EGF target cells, were not affected by either factor XII or factor XIIa. Various doses of factor XII enhanced cell proliferation, [3H]thymidine incorporation, and [3H]leucine incorporation in HepG2 cells cultured under the same conditions. These data indicate that factor XII, like EGF, is a mitogen for HepG2 cells and suggest a possible autocrine role in the liver. Images PMID:1852005

Schmeidler-Sapiro, K T; Ratnoff, O D; Gordon, E M

1991-01-01

330

Prognostic factors in retroperitoneal fibrosis  

PubMed Central

The aim of this study is to evaluate effective prognostic factors in the evolution of patients with retroperitoneal fibrosis and to establish the validity of fractal analysis in determining the disease severity in these patients. Material and Methods: This study included 19 patients (M/F: 5/14) treated for idiopathic retroperitoneal fibrosis and bilateral obstructive renal failure between Jan 2004–Dec 2008. Patients were identified retrospectively, searching for patients diagnosed with IRF, after retroperitoneal biopsy or, in most cases the diagnosis rested on radiological findings, especially CT, with identification of a retroperitoneal mass, the absence of other demonstrable renal or ureteric disease or any other pathology that could explain the findings. CT was very useful in describing the retroperitoneal mass around the aorta and inferior vena cava, the extent of the lesion and for monitoring the response to surgical treatment during the follow–up. The data were evaluated about medical history, physical examination findings, laboratory tests (serum urea and creatinine, blood sugar, sodium, potassium, bicarbonate levels, serum pH, uric acid, haematocrit, white blood cell count), imaging methods (renal ultrasound, abdominal CT–scan, MRI). At admission all patients had active disease with obstructive renal failure and underwent bilateral ureteric stenting in order to normalize the BUN levels. After normalizing of BUN levels, ureterolysis and omental wrapping was performed. Postoperatively, ureteric stents were removed after 1 month and remission of renal disfunction was obtained in approximately 5 months (range 2–10 months). All patients were followed for at least 1 year. Patients were regularly checked every 3 months. Results: Of the 19 patients, there were 5 men and 14 women. The median age at diagnosis of RF was 50 years (range 42–64 years). The most frequent presenting symptoms were back or abdominal pain, weakness, weight loss, oligoanuria, arterial hypertension and mild fever. The duration of symptoms before diagnosis ranged from 6 to 18 months. At presentation all patients had active disease, presenting renal dysfunction with a median serum creatinine of 5.18 mg/dl (range 1–15.4 mg/dl). Most of the patients had moderate bilateral hydronephrosis (2nd degree hydronephrosis). In our study, all patients had excellent prognosis, with full recovery of renal function in 78% of cases (15 patients). The fractal dimension of the fibrosis mass contour correlates with level of renal function impairment. Even more, the fractal dimension seems to slightly variate between CT evaluations (1.30±0.1), suggesting a non aggressive pattern of extension of the fibrotic mass characteristic for benign lesions. Conclusions: The imaging parameters did not predict the disease severity, except the increase in fractal dimension of fibrosis surface area. Efficacy of bilateral ureteric stenting in improving renal function is limited in most of the cases. Dispite the level of renal function impairment at admission, full recovery can be achieved after bilateral ureteric stenting/nephrostomy and ureterolisis. PMID:20302193

Sinescu, I; Mirvald, C; Chibelean, C; Gîngu, C; Avram, D; Hîrza, M; Manu, M; Lazar, R; Savu, C; Udrea, A

2010-01-01

331

Intermittent claudication: prevalence and risk factors  

Microsoft Academic Search

Risk factors for intermittent claudication (IC) were studied in 54 patients--that is, all patients with IC on the lists of two general practices--and 108 controls. Smoking was the factor most strongly associated with the development of IC, but systolic and diastolic blood pressures and concentrations of triglyceride, urate, and fibrinogen were all significantly higher among the patients with IC than

W G Hughson; J I Mann; A Garrod

1978-01-01

332

Plant Selection Factors The City of  

E-print Network

Plant Selection Factors The City of OKLAHOMA CITY UTILITIES DEPARTMENT Oklahoma Cooperative-433 #12;Plan Before you Plant Plants add value to the home, provide shade, define space, and make us happy. Consider the following five plant selection factors when choosing plants for your landscape. Keep

Balasundaram, Balabhaskar "Baski"

333

Preservice Music Teachers' Employment Preferences: Consideration Factors  

ERIC Educational Resources Information Center

This study was designed to investigate preservice music teachers' (N = 187) perceptions of employment preferences when considering future teaching positions. Adaptive Conjoint Analysis, a business market-based research tool, was used to determine preferences for personal factors (e.g., salary, commute), school environmental factors (e.g.,…

Robinson, Nicole R.

2012-01-01

334

Dynamic Risk Factors: The Kia Marama Evaluation  

Microsoft Academic Search

Risk assessment is an essential part of clinical practice. Each of the three aspects of risk (static, stable, and acute dynamic) are important at various points of contact between the man and the systems that are responsible for providing service. Dynamic factors, the typical treatment and supervision targets, have received less research attention than static factors. This paper examined the

Stephen M. Hudson; David S. Wales; Leon Bakker; Tony Ward

2002-01-01

335

Computing Tolerance Factors And Noncentral t Distribution  

NASA Technical Reports Server (NTRS)

TF, Tolerance Factors and Noncentral t Distribution computer program, computes tolerance factor from normal-distribution sample for arbitrarily specified coverage probability, confidence level, and any positive (integer or noninteger) number of degrees of freedom. Used extensively in engineering and quality analyses. Used in place of reference tables. Written in Microsoft QuickBasic v2.0.

Huang, Zhaofeng

1995-01-01

336

Pseudo skin factor due to partial penetration  

Microsoft Academic Search

In this study the authors examine the pseudo skin factor due to partial penetration in a two-layer reservoir when only one layer is open to flow. They show that the pseudo skin factor can be correlated as a unique function of three reservoir parameters and in some cases can be accurately correlated as a function of two reservoir parameters. They

A. C. Reynolds; J. C. Chen; R. Raghavan

1983-01-01

337

Pseudo skin factor due to partial penetration  

Microsoft Academic Search

This study examines the pseudo skin factor due to partial penetration in a 2-layer reservoir when only one layer is open to flow. The pseudo skin factor can be correlated as a unique function of 3 reservoir parameters and in some cases can be correlated accurately as a function of 2 reservoir parameters. Graphs and procedures for estimating the pseudo

A. C. Reynolds; J. C. Chen; R. Raghavan

1983-01-01

338

Results from a Web Impact Factor Crawler.  

ERIC Educational Resources Information Center

Discusses Web impact factors (WIFs), Web versions of the impact factors for journals, and how they can be calculated by using search engines. Highlights include HTML and document indexing; Web page links; a Web crawler designed for calculating WIFs; and WIFs for United Kingdom universities that measured research profiles or capability. (Author/LRW)

Thelwall, Mike

2001-01-01

339

Demagnetizing factors for rectangular ferromagnetic prisms  

Microsoft Academic Search

An analytic expression is given for the magnetometric demagnetizing factors of the general rectangular prism, with special emphasis on the particular case of a square cross section. It is argued that this demagnetizing factor should be used in numerical computations that assume such prisms, when comparing the results with the theoretical study of ellipsoids.

Amikam Aharoni

1998-01-01

340

Quadratic Equations: From Factored to Standard Form  

NSDL National Science Digital Library

This activity leads students to understand the utility in the factored form of a quadratic equation. Students then express quadratic equations in standard form in the corresponding factored form. The activity is concluded with four critical-thinking questions. website: http://www.mathedpage.org/ copyright information: http://www.mathedpage.org/rights.html

2011-01-01

341

Risk Factor Intervention for Health Maintenance  

ERIC Educational Resources Information Center

Risk factors for disease consist of personal habits such as cigarette smoking and excessive alcohol consumption, and bodily characteristics such as hypertension and high serum cholesterol. Progress in identifying, quantifying, and controlling risk factors is opening the way to the prevention of disease. (BB)

Breslow, Lester

1978-01-01

342

Factors Affecting Retention in Online Courses  

ERIC Educational Resources Information Center

The purpose of this study was to expand what is known regarding the factors that relate to successful completion of online, undergraduate college courses. It addressed 13 student factors available through archival data at Northern Kentucky University based on 1,493 students enrolled in fully online courses in fall 2008. It included programmatic…

Berling, Victoria L.

2010-01-01

343

Photon impact factor in the NLO  

SciTech Connect

The photon impact factor for the BFKL pomeron is calculated in the next-to-leading order (NLO) approximation using the operator expansion in Wilson lines. The result is represented as a NLO k{sub T}-factorization formula for the structure functions of small-x deep inelastic scattering.

Balitsky, Ian [JLAB

2013-04-01

344

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2011-01-01

345

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2010-01-01

346

14 CFR 25.623 - Bearing factors.  

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used for a part...

2014-01-01

347

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2013-01-01

348

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2012-01-01

349

14 CFR 29.623 - Bearing factors.  

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2014-01-01

350

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used for a part...

2011-01-01

351

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2010-01-01

352

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used for a part...

2012-01-01

353

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used for a part...

2010-01-01

354

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2013-01-01

355

14 CFR 27.623 - Bearing factors.  

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2014-01-01

356

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2012-01-01

357

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used for a part...

2013-01-01

358

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...section, each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) No bearing factor need be used on a part for...

2011-01-01

359

Risk Factors for Forced Migrant Flight  

Microsoft Academic Search

An important type of medical study seeks to establish the risk factors for contracting various diseases. A similar, but very small, vein of research exists in peace and conflict studies, and we seek to contribute to it. Our study evaluates whether variables shown to explain variance in numbers of forced migrants can serve as risk factors that might aid contingency

Jacqueline H. Rubin; Will H. Moore

2007-01-01

360

Osteoporosis Risk Factors in Eighth Grade Students.  

ERIC Educational Resources Information Center

Presents findings from food frequency questionnaires and surveys of 138 Midwestern eighth-grade student-parent pairs. The study examined the incidence of modifiable and nonmodifiable osteoporosis risk factors and compared gender differences. Data analysis indicated that many adolescents possessed several modifiable and nonmodifiable risk factors

Lysen, Victoria C.; Walker, Robert

1997-01-01

361

Income distribution, factor endowments, and trade openness  

Microsoft Academic Search

This paper studies the empirical links among factor endowments, trade and personal income distribution. By using panel data, we show that land and capital intensive countries have a less equal income distribution while skill intensive countries have a more equal income distribution. We also show that the effects of trade openness on inequality depend on factor endowments in a way

Antonio Spilimbergo; Juan Luis Londońo; Miguel Székely

1999-01-01

362

Psychological Factors in Solar Observing. Final Report.  

ERIC Educational Resources Information Center

The report summarizes the aims of a 3-year program of work concerned with psychological factors in solar observing. Part I identifies several psychological factors which may affect solar observing and outlines a program of research. Part II is a report of a program of studies dealing with the application of visual perceptions in solar flare…

Pickett, Ronald M.

363

Vascular endothelial growth factor (VEGF) in endometriosis  

Microsoft Academic Search

Angiogenesis is likely to be involved in the pathogenesis of endometriosis. According to the transplantation theory, when the exfoliated endometrium is attached to the periton- eal layer, the establishment of a new blood supply is essential for the survival of the endometrial implant and development of endometriosis. From the known angiogenic factors, vascular endothelial growth factor (VEGF) has emerged as

Jacques Donnez; Pierre Smoes; Stephane Gillerot; Francoise Casanas-Roux; Michelle Nisolle

1998-01-01

364

Using Factor Analysis To Organize Student Services.  

ERIC Educational Resources Information Center

Exploratory factor analysis (EFA) was used to provide an organizational framework for data collected from an entering class of students (N=1,912). Results from the EFA indicated that items on surveys could be grouped into dimensions that can be used to plan student services. Factors that emerged included: Religion/Spirituality, Help Seeking,…

Majors, Mark S.; Sedlacek, William E.

2001-01-01

365

Growth factors from genes to clinical application  

SciTech Connect

The last decade has witnessed an explosion in the identification of growth factors and their receptors. This has been greatly facilitated by recombinant DNA technology, which has provided the tools not only to identify these proteins at the gene level but also to produce recombinant proteins for evaluating their biological activities. With the help of such techniques, we are moving toward an understanding of the biosynthesis of growth factors and their receptors, structure-function relationships, as well as mechanisms for intracellular signal transmission. The possibility of modifying these factors has opened new fields of clinical application. In this paper, four major areas of growth factor research are presented: the characterization of growth factor genes and their protein products, growth factor receptors and signal transduction by the receptors to mediate biological action, the biological actions of the various growth factors, and the role of growth factors in health and disease and their possible clinical application. Some of the topics covered include: structure of the IGFs and their variants; isoforms of PDGF receptor types; tyrosine kinase activation; structure of G-proteins in biological membranes; possible therapeutic application of NGF in the treatment of Parkinson's and Alzheimer's diseases; PDGF's possible role in the development of several fibroproliferative diseases and its therapeutic application in wound healing; and the possible use of angiogenic inhibitors in tumor treatment.

Sara, V.R. (Dept. of Pathology, Karolinska Hospital, Stockholm (SE)); Hall, K.; Low, H. (Dept. of Endocrinology, Karolinska Hospital, Stockholm (SE))

1990-01-01

366

Identifying target sites for cooperatively binding factors  

Microsoft Academic Search

Motivation: Transcriptional activation in eukaryotic organ- isms normally requires combinatorial interactions of multi- ple transcription factors. Though several methods exist for identification of individual protein binding site patterns in DNA sequences, there are few methods for discovery of binding site patterns for cooperatively acting factors. Here we present an algorithm, Co-Bind (for COperative BIND- ing), for discovering DNA target sites

Debraj Guha Thakurta; Gary D. Stormo

2001-01-01

367

How Student Satisfaction Factors Affect Perceived Learning  

ERIC Educational Resources Information Center

Data from students in two sections of a general education course offered at a research university in spring 2009 were used to explore whether student satisfaction factors are associated with perceived learning as rated by students. A list of 22 elements in the learning environment was explored. The 22 were used in creating 3 satisfaction factors

Lo, Celia C.

2010-01-01

368

Latent Factor Models for Web Recommender Systems  

E-print Network

, Raghu Ramakrishnan Yahoo! Research & Yahoo! Labs #12;2Bee-Chung Chen (beechun@yahoo-inc.com) Outline · Overview of recommender problems at Yahoo! · Basics of matrix factorization · Matrix factorization ­ Multi-objective optimization ­ Whole-page optimization #12;3Bee-Chung Chen (beechun@yahoo-inc.com) Web

Ghosh, Joydeep

369

Factor VIIa-Catalyzed Activation of Factor X Independent of Tissue Factor: Its Possible Significance for Control of Hemophilic Bleeding by Infused Factor VIIa  

Microsoft Academic Search

N 1974, Kurczynski and Pennerl confirmed the successful I use of activated prothrombin complex concentrate to control bleeding in patients with factor VI11 (FVIII) inhibi- tors. Five years later, Seligsohn et alz reported that factor VIIa (FVIIa) present in such concentrates circulates with an intravascular half-time of over 2 hours, and suggested that circulating FVIIa might have a hemostatic effect

L. Vijaya Mohan Rao; Samuel I. Rapaport

1990-01-01

370

Factors of Addiction: New Jersey Correctional Population  

ERIC Educational Resources Information Center

Most state inmates incarcerated under the jurisdiction of the New Jersey Department of Corrections are driven to crimes by drug abuse. Understanding the factors contributing to addiction is the first step in developing strategies for successful inmate reintegration. This study presents an analysis of inmate addiction and factor association using…

Wojtowicz, James P.; Liu, Tongyin; Hedgpeth, G. Wayne

2007-01-01

371

Dimensions of female sexuality: A factor analysis  

Microsoft Academic Search

The present study was designed to generate hypotheses about dimensions underlying female sexuality. The subjects were 138 undergraduate women who completed three questionnaires about their sexual attitudes and behavior. A factor analysis yielded seven factors that were labeled as follows: (1) overall level of heterosexual activity; (2) level of noncoital heterosexual satisfaction; (3) gratification from masturbation; (4) responsivity to coital

deRosset Myers; Peter R. Kilmann; Richard L. Wanlass; Anna Stout

1983-01-01

372

Factoring by Grouping: Making the Connection.  

ERIC Educational Resources Information Center

Presented is a method for factoring quadratic equations that helps the teacher demonstrate how to eliminate guessing through establishment of the connection between multiplication and factoring. Included are examples that allow the student to understand the link between the algebraic and the pictorial representations of quadratic equations. (JJK)

Kennedy, Paul A.; And Others

1991-01-01

373

Risk factors and cardiovascular disease in Turkey  

Microsoft Academic Search

Cardiovascular risk factors as well as morbidity and mortality from coronary heart disease among Turkish adults are herein reviewed. Lipids and lipoproteins are in focus, but other relevant risk factors are also discussed. Turks have distinctively low levels of total and high-density lipoprotein (HDL)-cholesterol, associated with high levels of hepatic lipase and fasting triglycerides. In addition, physical inactivity is common

Altan Onat

2001-01-01

374

Economic and Cultural Factors Affecting University Excellence  

ERIC Educational Resources Information Center

Purpose: The ranking of top universities in the world has generated increased interest in the factors that enhance university performance. The purpose of this paper is to identify economic and cultural factors that affect the number of top ranking universities in each country. Design/methodology/approach: This paper first identifies the number of…

Jabnoun, Naceur

2009-01-01

375

Human Factors Research and Nuclear Safety.  

ERIC Educational Resources Information Center

The Panel on Human Factors Research Needs in Nuclear Regulatory Research was formed by the National Research Council in response to a request from the Nuclear Regulatory Commission (NRC). The NRC asked the research council to conduct an 18-month study of human factors research needs for the safe operation of nuclear power plants. This report…

Moray, Neville P., Ed.; Huey, Beverly M., Ed.

376

Factors Contributing to Institutions Achieving Environmental Sustainability  

ERIC Educational Resources Information Center

Purpose: The purpose of this paper is to determine what factors contributed to three universities achieving environmental sustainability. Design/methodology/approach: A case study methodology was used to determine how each factor contributed to the institutions' sustainability. Site visits, fieldwork, document reviews, and interviews with…

James, Matthew; Card, Karen

2012-01-01

377

Developmental Risk Factors for Sexual Offending.  

ERIC Educational Resources Information Center

A study involving 64 Australian sex offenders and 33 non-sex offenders found childhood emotional abuse and family dysfunction, childhood behavior problems, and childhood sexual abuse were developmental risk factors for paraphilia. Emotional abuse and family dysfunction was found to be a risk factor for pedophilia, exhibitionism, rape, or multiple…

Lee, Joseph K. P.; Jackson, Henry J.; Pattison, Pip; Ward, Tony

2002-01-01

378

Factor Scores, Structure Coefficients, and Communality Coefficients  

ERIC Educational Resources Information Center

This paper presents heuristic explanations of factor scores, structure coefficients, and communality coefficients. Common misconceptions regarding these topics are clarified. In addition, (a) the regression (b) Bartlett, (c) Anderson-Rubin, and (d) Thompson methods for calculating factor scores are reviewed. Syntax necessary to execute all four…

Goodwyn, Fara

2012-01-01

379

Psychosocial factors in juvenile diabetes: A review  

Microsoft Academic Search

Studies assessing (1) the influence of psychosocial factors on the onset of juvenile diabetes, (2) the influence of psychosocial factors on the course of this disease, and (3) the influence of diabetes on the psychosocial development of the child are reviewed. Directions for future research are suggested.

Suzanne Bennett Johnson

1980-01-01

380

Contextual Factors in Second Language Acquisition  

Microsoft Academic Search

While many discussions about learning a second language focus on teaching methodologies, little emphasis is given to the contextual factors—individual, social, and societal—that affect students' learning. These contextual factors can be con- sidered from the perspective of the language, the learner, and the learning process. This digest discusses these perspectives as they relate to learning any second language, with a

AÍDA WALQUI

381

Is Subjective Status Influenced by Psychosocial Factors?  

ERIC Educational Resources Information Center

Objective: Associations between subjective status and health are still relatively unexplored. This study aimed at testing whether subjective status is uniquely confounded by psychosocial factors compared to objective status, and what factors that may predict subjective status. Design: A cross-sectional analysis of a population-based, random sample…

Lundberg, Johanna; Kristenson, Margareta

2008-01-01

382

FACTORS BEHIND BRAND SWITCHING IN CELLULAR NETWORKS  

Microsoft Academic Search

Factors affecting customer satisfaction has great importance in order to know the reasons and facts that are responsible behind switching in cellular network. Customers are satisfied, when their desires, wishes & needs are fulfill by any brand, used by them. In case of different brands of cellular network like ufone, factors like: Price, service quality, trust and brand loyalty play

Sarwat Afzal; Aamir Khan Chandio; Sania Shaikh; Muskan Bhand; Bais Ali Ghumro

2013-01-01

383

Dietary Research - Risk Factor Monitoring & Methods Branch  

Cancer.gov

Diet, in all its complexity, is considered one of the major risk factors for cancer and is therefore a primary area of research within the Risk Factor Monitoring and Methods Branch. We work collaboratively with a wide range of researchers to conduct an integrated program that serves NCI as well as the extramural community.

384

Factors Related to Smoking in College Women  

Microsoft Academic Search

Cigarette smoking among American women attending college has increased dramatically since the 1980's. To develop effective smoking prevention and cessation programs, a better understanding of factors associated with smoking in college women is needed. Therefore, the purpose of this study was to examine if selected factors (stress, stress management, nutrition, physical activity, alcohol consumption, and race) were related to smoking

Marlene C. Mackey; Selina Hunt McKinney; Abbas Tavakoli

2008-01-01

385

Managerial Success Factors: A Chinese Profile  

ERIC Educational Resources Information Center

This article reports on an exploratory study conducted in the People's Republic of China (PRC) to identify the managerial success factors perceived by Chinese managers to be important in their market economy. The study also looked at how these factors are exhibited by recent graduates of Chinese universities now working in Chinese firms.…

Stivers, Bonnie P.; Adams, Janet S.; Liu, Bin

2007-01-01

386

Factors Influencing Career Choice among Police Recruits  

ERIC Educational Resources Information Center

This quantitative, non-experimental study examined the career choice factors of 154 (n = 154) police recruits to determine a correlation of age group generation to the five career choice factors presented in the Sibson Reward of Work Model. Law enforcement agencies faced a shortage of viable candidates to fill vacant positions. While extensive…

Cole, Bryan

2012-01-01

387

Factor Analytic Structure of the MCMI Items.  

ERIC Educational Resources Information Center

The factor analytic studies that have been done with the Millon Clinical Multiaxial Inventory (MCMI), a 175-item paper-and-pencil test designed to evaluate symptomology in psychiatric patients, have been problematic in that the test's high inter-scale correlation could lead to an artificially robust factor structure. The present investigation…

Choca, James; And Others

388

Status of Risk Factors for Vascular Dementia  

Microsoft Academic Search

The two most common causes of vascular dementia (VAD) are dementia evolving in connection with multiple small or large strokes and dementia related to ischemic white-matter lesions (WMLs) of the brain. The knowledge about risk factors for these disorders is still scarce. Besides sharing risk factors with stroke, dementia with multiple small or large brain infarcts is also associated with

Ingmar Skoog

1998-01-01

389

Human factors considerations for aviation security technologies  

Microsoft Academic Search

All of the civil aviation security technologies being used worldwide have one thing in common-the ultimate decision about whether a bag will be placed on a plane rests in the mind of a human. Continued improvements in aviation security accordingly require human factors interventions to further enhance person-machine performance. This paper discusses the nascent field of aviation security human factors

E. C. Neiderman; J. L. Fobes

1999-01-01

390

Risk factors identified for certain lymphoma subtypes  

Cancer.gov

In a large international collaborative analysis of risk factors for non-Hodgkin lymphoma (NHL), scientists were able to quantify risk associated with medical history, lifestyle factors, family history of blood or lymph-borne cancers, and occupation for 11 different NHL subtypes, including less common subtypes.

391

Human Factors Simulation in Construction Management Education  

ERIC Educational Resources Information Center

Successful construction management depends primarily on the representatives of the involved construction project parties. In addition to effective application of construction management tools and concepts, human factors impact significantly on the processes of any construction management endeavour. How can human factors in construction management…

Jaeger, M.; Adair, D.

2010-01-01

392

Transcription Factor Pathways and Congenital Heart Disease  

PubMed Central

Congenital heart disease is a major cause of morbidity and mortality throughout life. Mutations in numerous transcription factors have been identified in patients and families with some of the most common forms of cardiac malformations and arrhythmias. This review discusses factor pathways known to be important for normal heart development and how abnormalities in these pathways have been linked to morphological and functional forms of congenital heart defects. A comprehensive, current list of known transcription factor mutations associated with congenital heart disease is provided, but the review focuses primarily on three key transcription factors, Nkx2-5, GATA4, and Tbx5, and their known biochemical and genetic partners. By understanding the interaction partners, transcriptional targets, and upstream activators of these core cardiac transcription factors, additional information about normal heart formation and further insight into genes and pathways affected in congenital heart disease should result. PMID:22449847

McCulley, David J.; Black, Brian L.

2013-01-01

393

Neutron Spectroscopic Factors from Transfer Reactions  

E-print Network

The present paper examines past measurements of the angular distributions for (d,p) and (p,d) reactions on targets with Z=3-24 leading to the ground states. The procedure is prescribed for extracting a conventional set of spectroscopic factors. Most of these spectroscopic factors agree well with large-basis shell model predictions. In all, the ground state neutron spectroscopic factors for 80 nuclei have been obtained. The consistency of the method is evaluated by comparing spectroscopic factors obtained separately in (p,d) and (d,p) reactions. The values correlate with Endt's compilation when available, but the current method is more general and the spectroscopic factor values obtained are more consistent with each other.

Jenny Lee; M. B. Tsang; W. G. Lynch

2006-02-19

394

Human Factors in Cabin Accident Investigations  

NASA Technical Reports Server (NTRS)

Human factors has become an integral part of the accident investigation protocol. However, much of the investigative process remains focussed on the flight deck, airframe, and power plant systems. As a consequence, little data has been collected regarding the human factors issues within and involving the cabin during an accident. Therefore, the possibility exists that contributing factors that lie within that domain may be overlooked. The FAA Office of Accident Investigation is sponsoring a two-day workshop on cabin safety accident investigation. This course, within the workshop, will be of two hours duration and will explore relevant areas of human factors research. Specifically, the three areas of discussion are: Information transfer and resource management, fatigue and other physical stressors, and the human/machine interface. Integration of these areas will be accomplished by providing a suggested checklist of specific cabin-related human factors questions for investigators to probe following an accident.

Chute, Rebecca D.; Rosekind, Mark R. (Technical Monitor)

1996-01-01

395

Molecular analysis of factor XII gene in Thai patients with factor XII deficiency.  

PubMed

Factor XII is the initiating protein of the intrinsic coagulation pathway. It activates factor X after being activated by the so called 'contact system'. Both congenital factor XII deficiency, usually without bleeding symptoms, and several factor XII polymorphisms with possible thrombotic tendency have been described. In the presented work, two Thai patients with congenital factor XII deficiency have been studied by utilizing a PCR single-stranded conformation polymorphism (PCR-SSCP) method followed by direct sequencing. A new mutation of factor XII gene in the exon 7, c.583delC or p.H195fsX250, has been discovered and variable factor activities resulting from different mutations with or without polymorphisms are demonstrated. The other case had a homozygous missense mutation, c.G218C. Heterozygotes of this mutation, found in 1.9% (2/107) of healthy Thai volunteers, showed low factor XII activities suggesting that it is a deleterious mutation. PMID:23492916

Singhamatr, Pon; Kanjanapongkul, Somjai; Rojnuckarin, Ponlapat

2013-09-01

396

Effects of dietary factors on energy regulation: consideration of multiple- versus single-dietary-factor models.  

PubMed

While short-term studies demonstrate consistent effects of dietary protein, fiber, glycemic index and energy density on energy intake, long-term effectiveness trials typically indicate small or non-significant effects of these dietary factors on long-term weight change. In consequence, most lifestyle interventions for weight control typically focus on a single dietary factor, such as low energy density, to achieve reductions in energy intake. This paper proposes a multiple-dietary-factor model for the effects of dietary factors on energy intake and the regulation of energy balance that assumes additive effects of different dietary factors. The model is consistent with emerging evidence from recent studies examining pairs of dietary factors. Randomized clinical trials are now needed to determine whether multiple-dietary-factor prescriptions combined with standard behavior modification techniques lead to improved sustainability of weight loss in lifestyle interventions compared to conventional single-dietary-factor prescriptions. PMID:24747274

Roberts, Susan B; Urban, Lorien E; Das, Sai Krupa

2014-07-01

397

Exploratory factor analysis in behavior genetics research: Factor recovery with small sample sizes  

E-print Network

Results of a Monte Carlo study of exploratory factor analysis demonstrate that in studies characterized by low sample sizes the population factor structure can be adequately recovered if communalities are high, model error ...

Preacher, K. J.; MacCallum, R. C.

2002-01-01

398

A Bayesian Estimation of Factor Score in Confirmatory Factor Model with Polytomous, Censored or Truncated Data.  

ERIC Educational Resources Information Center

Explores posterior analysis in estimating factor score in a confirmatory factor analysis model with polytomous, censored or truncated data, and studies the accuracy of Bayesian estimates through simulation. Results support these Bayesian estimates for statistical inference. (SLD)

Shi, Jian-Qing; Lee, Sik-Yum

1997-01-01

399

Scatter factor\\/hepatocyte growth factor is essential for liver development  

Microsoft Academic Search

POLYPEPTIDE growth factors are important effectors of cell growth and differentiation in vitro and are thought to be critical for processes such as specification of cell fate, tissue growth and organogenesis in vivo. Scatter factor1-3\\/hepatocyte growth factor4,5 (SF\\/HGF) is the prototype of an emerging family of growth factors that resemble in their domain structure and mechanism of activation the blood

Claudia Schmidt; Friedhelm Bladt; Stefanie Goedecke; Volker Brinkmann; Wolfgang Zschiesche; Melanie Sharpe; Ermanno Gherardi; Carmen Birchmeler

1995-01-01

400

Effects of friction factor and slip factor on the performance of a centrifugal slurry pump  

E-print Network

EFFECTS OF FRICTION FACTOR AND SLIP FACTOR ON THE PERFORMANCE OF A CENTRIFUGAL SLURRY PUMP A Thesis by KETANKUMAR KANTILAL SHETH Submitted to the Graduate College of Texas ASM University in partial fulfillment of the requirements... for the degree of MASTER OF SCIENCE August 1985 Ma]or Sub]ect: Mechanical Engineering EFFECTS OF FRICTION FACTOR AND SLIP FACTOR ON THE PERFORMANCE OF A CENTRIFUGAL SLURRY PUMP A Thesis by KETANKUMAR KANTILAL SHETH Approved as to style and content by...

Sheth, Ketankumar Kantilal

2012-06-07

401

Human factors in safety and business management.  

PubMed

Human factors in safety is concerned with all those factors that influence people and their behaviour in safety-critical situations. In aviation these are, for example, environmental factors in the cockpit, organisational factors such as shift work, human characteristics such as ability and motivation of staff. Careful consideration of human factors is necessary to improve health and safety at work by optimising the interaction of humans with their technical and social (team, supervisor) work environment. This provides considerable benefits for business by increasing efficiency and by preventing incidents/accidents. The aim of this paper is to suggest management tools for this purpose. Management tools such as balanced scorecards (BSC) are widespread instruments and also well known in aviation organisations. Only a few aviation organisations utilise management tools for human factors although they are the most important conditions in the safety management systems of aviation organisations. One reason for this is that human factors are difficult to measure and therefore also difficult to manage. Studies in other domains, such as workplace health promotion, indicate that BSC-based tools are useful for human factor management. Their mission is to develop a set of indicators that are sensitive to organisational performance and help identify driving forces as well as bottlenecks. Another tool presented in this paper is the Human Resources Performance Model (HPM). HPM facilitates the integrative assessment of human factors programmes on the basis of a systematic performance analysis of the whole system. Cause-effect relationships between system elements are defined in process models in a first step and validated empirically in a second step. Thus, a specific representation of the performance processes is developed, which ranges from individual behaviour to system performance. HPM is more analytic than BSC-based tools because HPM also asks why a certain factor is facilitating or obstructing success. A significant need for research and development is seen here because human factors are of increasing importance for organisational success. This paper suggests integrating human factors in safety management of aviation businesses - a top-ranking partner of technology and finance - and managing it with professional tools. The tools HPM and BSC were identified as potentially useful for this purpose. They were successfully applied in case studies briefly presented in this paper. In terms of specific safety-steering tools in the aviation industry, further elaboration and empirical study is crucial. Statement of Relevance: The importance of human factors is recognised by operators at the sharp end of aviation, where flights are conducted or coordinated. At the blunt end, measurement tools are needed to manage operational resources. PMID:20099171

Vogt, Joachim; Leonhardt, Jorg; Koper, Birgit; Pennig, Stefan

2010-02-01

402

Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer  

Microsoft Academic Search

Solid tumors must induce a vascular stroma to grow beyond a minimal size, and the intensity of the angiogenic response has been correlated with prognosis in breast cancer patients. Vascular permeability factor (VPF), also known as vascular endothelial growth factor (VEGF), is a secreted protein that has been implicated in tumor-associated angiogenesis. Vascular permeability factor directly stimulates endothelial cell growth

Lawrence F Brown; Brygida Berse; Robert W Jackman; Kathi Tognazzi; Anthony J Guidi; Harold F Dvorak; Donald R Senger; James L Connolly; Stuart J Schnitt

1995-01-01

403

Exposure factors resources: contrasting EPA?s Exposure Factors Handbook with international sources(journal article)  

EPA Science Inventory

Efforts to compile and standardize exposure human factors have resulted in the development of a variety of resources available to the scientific community. For example, the U.S. EPA developed the Exposure Factors Handbook and Child-specific Exposure Factors Handbook to promote c...

404

Stem cell factor is a chemoattractant and a survival factor for CNS stem cells  

Microsoft Academic Search

Migration of neural cells to their final positions is crucial for the correct formation of the central nervous system. Several extrinsic factors are known to be involved in the regulation of neural migration. We asked if stem cell factor (SCF), well known as a chemoattractant and survival factor in the hematopoietic lineage, could elicit similar responses in neural stem cells.

Anna Erlandsson; Jimmy Larsson; Karin Forsberg-Nilsson

2004-01-01

405

ESTIMATED RUMINAL PRODUCTION OF PSEUDOVITAMIN Bl 2, FACTOR A AND FACTOR B IN SHEEP l  

Microsoft Academic Search

SUMMARY Digesta samples from experiments in which ruminal vitamin B t 2 production was quantita- tively estimated were used for electrophoretic separation and estimation of ruminal produc- tion of pseudovitamin B12, Factor A and Factor B. Mean estimates based on 61 samples representing a variety of diets were (gtg\\/g digestible dry matter intake + SE): pseudo-B12, .52 -+ .10; Factor

G. W. Bigger; M. Elliot; T. R. Rickard

2010-01-01

406

Bootstrap Confidence Intervals for Ordinary Least Squares Factor Loadings and Correlations in Exploratory Factor Analysis  

ERIC Educational Resources Information Center

This article is concerned with using the bootstrap to assign confidence intervals for rotated factor loadings and factor correlations in ordinary least squares exploratory factor analysis. Coverage performances of "SE"-based intervals, percentile intervals, bias-corrected percentile intervals, bias-corrected accelerated percentile intervals, and…

Zhang, Guangjian; Preacher, Kristopher J.; Luo, Shanhong

2010-01-01

407

A Validation of the Factor Structure of OQ-45 Scores Using Factor Mixture Modeling  

ERIC Educational Resources Information Center

This study investigated the Outcome Questionnaire's (OQ-45) factor structure and demonstrated the use of factor mixture modeling (FMM) for the purpose of score validation. OQ-45 scores did not fit the one-class, one- and three-factor models. Use of FMM to identify a two-class model is detailed. Implications for OQ-45 users are provided. (Contains…

Kim, Seong-Hyeon; Beretvas, S. Natasha; Sherry, Alissa R.

2010-01-01

408

The factorization of the ninth Fermat number version 19910227 The factorization of the ninth Fermat number  

E-print Network

in 1640 by the French mathematician Pierre de Fermat (1601--1665), whose interest in the problemThe factorization of the ninth Fermat number version 19910227 The factorization of the ninth Fermat prime factorization of the ninth Fermat number F9=2 512 +1 is exhibited. It is the product of three

Manasse, Mark S. - Microsoft Research

409

Factor Determinants of Total Factor Productivity Growth in the Malaysian Hotel Industry: A Stochastic Frontier Approach  

Microsoft Academic Search

This study applies stochastic frontier analysis to data on Malaysian hotels from 2002 to 2004 to decompose total factor productivity growth into technical progress and technical efficiency change. The study also identifies the factors that determine each total factor productivity component. For this time period, Malaysian hotels operated at an average efficiency of 41 percent; and average technical efficiency change,

Sangho Kim

2011-01-01

410

Full Information Item Factor Analysis of the FCI  

Microsoft Academic Search

Traditional factor analytical methods, principal factors or principal components analysis, are inappropriate techniques for analyzing dichotomously scored responses to standardized tests or concept inventories because they lead to artifactual factors often referred to as ``difficulty factors.'' Full information item factor analysis (Bock, Gibbons and Muraki, 1988) based on Thurstone's multiple factor model and calculated using marginal maximum likelihood estimation, is

Eric Hagedorn

2010-01-01

411

Cardiovascular risk factor investigation: a pediatric issue  

PubMed Central

Objectives To correlate cardiovascular risk factors (e.g., hypertension, obesity, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, sedentariness) in childhood and adolescence with the occurrence of cardiovascular disease. Sources A systematic review of books and selected articles from PubMed, SciELO and Cochrane from 1992 to 2012. Summary of findings Risk factors for atherosclerosis are present in childhood, although cardiovascular disease arises during adulthood. This article presents the main studies that describe the importance of investigating the risk factors for cardiovascular diseases in childhood and their associations. Significant rates of hypertension, obesity, dyslipidemia, and sedentariness occur in children and adolescents. Blood pressure needs to be measured in childhood. An increase in arterial blood pressure in young people predicts hypertension in adulthood. The death rate from cardiovascular disease is lowest in children with lower cholesterol levels and in individuals who exercise regularly. In addition, there is a high prevalence of sedentariness in children and adolescents. Conclusions Studies involving the analysis of cardiovascular risk factors should always report the prevalence of these factors and their correlations during childhood because these factors are indispensable for identifying an at-risk population. The identification of risk factors in asymptomatic children could contribute to a decrease in cardiovascular disease, preventing such diseases as hypertension, obesity, and dyslipidemia from becoming the epidemics of this century. PMID:23515212

Rodrigues, Anabel N; Abreu, Glaucia R; Resende, Rogério S; Goncalves, Washington LS; Gouvea, Sonia Alves

2013-01-01

412

Activation of hageman factor by collagen  

PubMed Central

Purified acid-soluble and insoluble human collagen accelerated the clotting of plateletpoor plasma in silicone-treated tubes. The clot-promoting effect did not appear to be due to thromboplastic activity since the collagen preparations did not activate factor X in the presence of factor VII and calcium. Instead, collagen appeared to accelerate clotting by activating Hageman factor (factor XII) on the basis of the following findings: collagen increased the clot-promoting activity of partially purified Hageman factor but exerted no further effect in the presence of kaolin, a known activator of Hageman factor; clot-promoting eluates were obtained from collagen exposed to normal, hemophilic, or PTC-deficient plasma but not from collagen exposed to Hageman or PTA-deficient plasma. The collagen molecule itself appeared to be required for the clot-promoting activity since digestion with collagenase or thermal denaturation at pH 2.5 (about 35°C) resulted in very marked reduction in clot-promoting activity. Since thermal denaturation is associated with transformation of collagen structure from triple helical to random coil form, it is suggested that the native form of collagen is essential for the ability to activate Hageman factor. Blockage of the free amino groups by treatment with nitrous acid or dinitrofluorobenzene only slightly reduced the clot-promoting activity of collagen. In contrast, since addition of cationic proteins to collagen markedly reduced pro-coagulant activity it is suggested that negatively charged sites on the collagen molecule are critical for Hageman factor activation. This suggestion is supported by the finding that pepsin treatment of collagen, which removes the predominantly negatively charged telopeptides, results in significant decrease in coagulant activity. Esterification of collagen, which neutralizes 80-90% of the free carboxyl groups, reduced coagulant activity by over 90% and it is suggested that the free carboxyl groups of glutamic and aspartic acids provide the negatively charged sites critical for Hageman factor activation. PMID:4302176

Wilner, G. D.; Nossel, H. L.; LeRoy, E. C.

1968-01-01

413

Dispersion Theory Methods for Transition Form Factors  

NASA Astrophysics Data System (ADS)

Dispersion-theoretical analyses of transition form factors are stepping stones to a model-independent determination of the light-by-light scattering contribution to (g - 2)?. We extend a calculation of the conversion decays of the lightest isoscalar vector mesons, ?/? ? ?0?+?-, that builds on a previous dispersive analysis of the ?/? ? 3? partial-wave amplitudes and the pion vector form factor as its sole ingredients. We construct a good parametrization of e+e- ? 3? that, together with information on the anomalous process ?? ? ??, allows us to obtain a description of the ?0 transition form factor measured in e+e- ? ?0?.

Schneider, Sebastian P.

2014-12-01

414

Synthetic heparin-binding factor analogs  

DOEpatents

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain, and preferably two peptide chains branched from a dipeptide branch moiety composed of two trifunctional amino acid residues, which peptide chain or chains bind a heparin-binding growth factor receptor and are covalently bound to a non-signaling peptide that includes a heparin-binding domain, preferably by a linker, which may be a hydrophobic linker. The synthetic heparin-binding growth factor analogs are useful as pharmaceutical agents, soluble biologics or as surface coatings for medical devices.

Pena, Louis A. (Poquott, NY); Zamora, Paul O. (Gaithersburg, MD); Lin, Xinhua (Plainview, NY); Glass, John D. (Shoreham, NY)

2010-04-20

415

Fundamentals of systems ergonomics/human factors.  

PubMed

Ergonomics/human factors is, above anything else, a systems discipline and profession, applying a systems philosophy and systems approaches. Many things are labelled as system in today's world, and this paper specifies just what attributes and notions define ergonomics/human factors in systems terms. These are obviously a systems focus, but also concern for context, acknowledgement of interactions and complexity, a holistic approach, recognition of emergence and embedding of the professional effort involved within organization system. These six notions are illustrated with examples from a large body of work on rail human factors. PMID:23684119

Wilson, John R

2014-01-01

416

Unidentified factors in the nutrition of chickens  

E-print Network

and pantothenic acid to dbcts containing no ?nimsl protein did not improve hatchability'v Rd. tson and his assooiates ('46) showed that tg cow manure ~d hatchability of eggs from hens fed a diet high in soybean meal and prevented the seasonal variation c... Bird et al, ('46) demonstrated that cow manure contained the factor found in fish meal Rub1n and B1rd ('ly5a) concentrated the cow manure factor3 andv Rubin and Bird (~46b) demonstrated that the droppings of hens contained cow manure factor activity...

Dieckert, Julius Walter

2012-06-07

417

Phenomenology of the Deuteron Electromagnetic Form Factors  

E-print Network

A rigorous extraction of the deuteron charge form factors from tensor polarization data in elastic electron-deuteron scattering, at given values of the 4-momentum transfer, is presented. Then the world data for elastic electron-deuteron scattering is used to parameterize, in three different ways, the three electromagnetic form factors of the deuteron in the 4-momentum transfer range 0-7 fm^-1. This procedure is made possible with the advent of recent polarization measurements. The parameterizations allow a phenomenological characterization of the deuteron electromagnetic structure. They can be used to remove ambiguities in the form factors extraction from future polarization data.

TheJLAB t20 collaboration; D. Abbott

2000-02-04

418

Proton-tissue dose buildup factors  

NASA Technical Reports Server (NTRS)

When an object is exposed to external radiation, the dose field within the object is a complicated function of the character of the external radiation, the shape of the object (including orientation), and the object's material composition. In this note, the dose conversion factors for protons in tissue are represented using buildup factors. A parametric form for the buildup factors is obtained. The values of the parameters are derived from Monte Carlo calculations of various authors. All the necessary information to estimate nuclear reaction effects in proton irration of convex objects of arbitrary shape is included.

Wilson, J. W.; Khandelwal, G. S.

1976-01-01

419

The motion commotion: Human factors in transportation  

NASA Technical Reports Server (NTRS)

The program for a systems approach to the problem of incorporating human factors in designing transportation systems is summarized. The importance of the human side of transportation is discussed along with the three major factors related to maintaining a mobile and quality life. These factors are (1) people, as individuals and groups, (2) society as a whole, and (3) the natural environment and man-made environs. The problems and bottlenecks are presented along with approaches to their solutions through systems analysis. Specific recommendations essential to achieving improved mobility within environmental constraints are presented.

Millar, A. E., Jr. (editor); Rosen, R. L. (editor); Gibson, J. D. (editor); Crum, R. G. (editor)

1972-01-01

420

Form Factors and Dyson-Schwinger Equations  

E-print Network

A synopsis exemplifying the employment of Dyson-Schwinger equations in the calculation and explanation of hadron electromagnetic form factors and related phenomena. In particular the contribution: presents the pion form factor computed simultaneously at spacelike and timelike momenta; reports aspects of the evolution of the nucleon and Delta masses with current-quark mass and the correlation of their mass difference with that between scalar and axial-vector diquarks; describes an estimate of the s-quark content of a dressed u-quark and its impact on the nucleon's strangeness magnetic moment; and comments upon the domain within which a pseudoscalar meson cloud can materially contribute to hadron form factors.

I. C. Cloet; C. D. Roberts

2008-11-13

421

Diatomic Hoenl-London factor computer program  

SciTech Connect

A new method is presented for computation of diatomic rotational line strengths, or Hoenl-London factors. The traditional approach includes separately calculating line positions and Hoenl-London factors and assigning parity labels. The present approach shows that one merely computes the line strength for all possible term differences and discards those differences for which the strength vanishes. Numerical diagonalization of the upper and lower Hamiltonians is used, which directly obtains the line positions, Hoenl-London factors, total parities, and e/f parities for both heteronuclear and homonuclear diatomic molecules. The fortran computer program discussed is also applicable for calculating n-photon diatomic spectra.

Hornkohl, James O.; Parigger, Christian G.; Nemes, Laszlo

2005-06-20

422

Mucus-stimulating factor in tears.  

PubMed

Mechanisms responsible for regulation of tear film mucus are poorly understood. Humoral factors responsible for stimulation of mucus secretion can be studied in vitro by using the free-swimming urn cell, a normal component of the coelomic fluid of the marine invertebrate Sipunculus nudus. With this system, a tear mucus-stimulating factor was found in normal human tears but was markedly decreased in patients with dry eye syndromes. It is suggested that a mucus-stimulating factor exists in normal human tears and that a decrease in this substance may be instrumental in the pathophysiology of certain dry eye syndromes. PMID:7358498

Franklin, R M; Bang, B G

1980-04-01

423

Multi sensor transducer and weight factor  

NASA Technical Reports Server (NTRS)

A multi-sensor transducer and processing method allow insitu monitoring of the senor accuracy and transducer `health`. In one embodiment, the transducer has multiple sensors to provide corresponding output signals in response to a stimulus, such as pressure. A processor applies individual weight factors to reach of the output signals and provide a single transducer output that reduces the contribution from inaccurate sensors. The weight factors can be updated and stored. The processor can use the weight factors to provide a `health` of the transducer based upon the number of accurate versus in-accurate sensors in the transducer.

Immer, Christopher D. (Inventor); Lane, John (Inventor); Eckhoff, Anthony J. (Inventor); Perotti, Jose M. (Inventor)

2004-01-01

424

Assessment of International Work on Organizational Factors  

SciTech Connect

This report describes the concept of organizational factors and includes a consensus definition. It summarizes existing methods for assessing organizations from a safety culture perspective, for analyzing past incidents at plants to assess the role of safety culture, and for using such incident analysis to provide a database supporting organizational factors models. It describes existing methods that potentially could be extended to quantify organizational factors in a Probabilistic Safety Analysis. It concludes that no method is clearly superior for this purpose and recommends the organization of a workshop to clarify important issues prior to selecting a method.

Wall, Ian

2002-06-01

425

Extrapolation, uncertainty factors, and the precautionary principle.  

PubMed

This essay examines the relationship between the precautionary principle and uncertainty factors used by toxicologists to estimate acceptable exposure levels for toxic chemicals from animal experiments. It shows that the adoption of uncertainty factors in the United States in the 1950s can be understood by reference to the precautionary principle, but not by cost-benefit analysis because of a lack of relevant quantitative data at that time. In addition, it argues that uncertainty factors continue to be relevant to efforts to implement the precautionary principle and that the precautionary principle should not be restricted to cases involving unquantifiable hazards. PMID:21802639

Steel, Daniel

2011-09-01

426

Associations of intrauterine growth restriction with placental pathological factors, maternal factors and fetal factors; clinicopathological findings of 257 Japanese cases.  

PubMed

Intrauterine growth restriction (IUGR) is the leading cause of fetal mortality and morbidity. As an etiology, each of placental findings, maternal factors and fetal factors has been reported to be associated with IUGR, although a comprehensive approach to examine all of these parameters as a cause of IUGR has not been reported. In the present study, therefore, we comprehensively examined the placental findings and maternal and fetal factors in the cases of IUGR (n=257, mean maternal age, 30 years; gestational weeks, 34 weeks) and normal growth pregnancies (n=258, mean maternal age, 30 years; gestational weeks, 33 weeks), and determined risk factors for IUGR. The prevalence of pregnancy hypertension (PHT) (19% vs. 8%, P<0.01), smoking habit (3% vs. 0.7%, P<0.05) and fetal anomaly (3.5% vs. 0.8%, P<0.05) were higher in IUGR cases than normal growth pregnancies. Pathologically, the prevalence of infarction (33% vs. 14%, P<0.05), fetal vessel thrombosis (22% vs. 6%, P<0.001) and chronic villitis (11% vs. 3%, P<0.001) were higher in IUGR cases than those in normal growth pregnancies. A multivariable regression analysis revealed that maternal factors (PHT), fetal factors (anomaly), and placental findings (infarction, fetal vessel thrombosis, and chronic villitis) are independently associated with increased risk of IUGR (all P<0.01). PMID:23233065

Sato, Y; Benirschke, K; Marutsuka, K; Yano, Y; Hatakeyama, K; Iwakiri, T; Yamada, N; Kodama, Y; Sameshima, H; Ikenoue, T; Asada, Y

2013-01-01

427

Testing for Heterogeneous Factor Loadings Using Mixtures of Confirmatory Factor Analysis Models  

PubMed Central

The current study assessed the viability of mixture confirmatory factor analysis (CFA) for measurement invariance testing by evaluating the ability of mixture CFA models to identify differences in factor loadings across populations with identical mean structures. Using simulated data from a model with known parameters, convergence rates, parameter recovery, and the power of the likelihood-ratio test were investigated as impacted by sample size, latent class proportions, magnitude of factor loading differences, percentage of non-invariant factor loadings, and pattern of non-invariant factor loadings. Results suggest that mixture CFA models may be a viable option for testing the invariance of factor loadings; however, without differences in latent means and measurement intercepts, results suggest that larger sample sizes, more non-invariant factor loadings, and larger amounts of heterogeneity are needed to successfully estimate parameters and detect differences across latent classes. PMID:21833229

Buzick, Heather M.

2010-01-01

428

Diagnostic Testing for Male Factor Infertility  

MedlinePLUS

... PATIENT FACT SHEET Diagnostic Testing for Male Factor Infertility When a couple has trouble having a baby, ... to find out what may be causing your infertility. Semen analysis Semen analysis is probably the first ...

429

High quality-factor optical resonators  

NASA Astrophysics Data System (ADS)

Various resonators are investigated for microwave photonic applications. Micro-sphere, disk and fiber ring resonators were designed, realized and characterized. Obtained quality factors are as high as Q = 1010.

Henriet, Rémi; Salzenstein, Patrice; Ristic, Davor; Coillet, Aurélien; Mortier, Michel; Rasoloniaina, Alphonse; Saleh, Khaldoun; Cibiel, Gilles; Dumeige, Yannick; Ferrari, Maurizio; Chembo, Yanne K.; Llopis, Olivier; Féron, Patrice

2014-09-01

430

External Factors Affecting Fusion Energy Development  

NASA Astrophysics Data System (ADS)

A number of external factors affecting the pace and direction of fusion energy development are reviewed and discussed. These include the changing electric utility marketplace environment, the availability of fossil fuels, competing power sources, and environmental issues.

Dean, Stephen O.

1999-06-01

431

Genetics Home Reference: Factor V Leiden thrombophilia  

MedlinePLUS

... and Families Resources for Health Professionals What glossary definitions help with understanding factor V Leiden thrombophilia? blood ... protein ; pulmonary ; surgery ; thrombophilia ; thrombosis You may find definitions for these and many other terms in the ...

432

External Factors Affecting Fusion Energy Development  

Microsoft Academic Search

A number of external factors affecting the pace and direction of fusion energy development are reviewed and discussed. These include the changing electric utility marketplace environment, the availability of fossil fuels, competing power sources, and environmental issues.

Stephen O. Dean

1999-01-01

433

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...a) Each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) For control surface hinges and control...

2011-01-01

434

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...a) Each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) For control surface hinges and control...

2012-01-01

435

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...a) Each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) For control surface hinges and control...

2010-01-01

436

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...a) Each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) For control surface hinges and control...

2013-01-01

437

14 CFR 23.623 - Bearing factors.  

...a) Each part that has clearance (free fit), and that is subject to pounding or vibration, must have a bearing factor large enough to provide for the effects of normal relative motion. (b) For control surface hinges and control...

2014-01-01

438

Carbon Dioxide Emission Factors for Coal  

EIA Publications

The Energy Information Administration (EIA) has developed factors for estimating the amount of carbon dioxide emitted, accounting for differences among coals, to reflect the changing "mix" of coal in U.S. coal consumption.

1994-01-01

439

Risk factors across the eating disorders.  

PubMed

This study sought to examine risk and onset patterns in anorexia nervosa (AN), bulimia nervosa (BN), and binge eating disorder (BED). Women with AN (n=71), BN (n=66), BED (n=160) and non-psychiatric controls (n=323) were compared retrospectively on risk factors, symptom onset, and diagnostic migration. Eating disorder groups reported greater risk exposure than non-psychiatric controls. AN and BED differed on premorbid personality/behavioral problems, childhood obesity, and family overeating. Risk factors for BN were shared with AN and BED. Dieting was the most common onset symptom in AN, whereas binge eating was most common in BN and BED. Migration between AN and BED was rare, but more frequent between AN and BN and between BN and BED. AN and BED have distinct risk factors and onset patterns, while BN shares similar risk factors and onset patterns with both AN and BED. Results should inform future classification schemes and prevention programs. PMID:25103674

Hilbert, Anja; Pike, Kathleen M; Goldschmidt, Andrea B; Wilfley, Denise E; Fairburn, Christopher G; Dohm, Faith-Anne; Walsh, B Timothy; Striegel Weissman, Ruth

2014-12-15

440

Teachers' perceptions of occupational stress factors.  

PubMed

Perceptions of factors in occupational stress were examined using the 17 elementary and 25 high school teachers' gender, age, experience, and grade taught. Statistically significant differences were reported. PMID:7568599

Montalvo, A; Bair, J H; Boor, M

1995-06-01

441

ENVIRONMENTAL FACTORS AFFECTING BREAST CANCER SUSCEPTIBILITY  

EPA Science Inventory

Environmental Factors Affecting Breast Cancer Susceptibility Suzanne. E. Fenton US EPA, ORD, MD-67 NHEERL, Reproductive Toxicology Division, Research Triangle Park, NC 27711. Breast cancer is still the most common malignancy afflicting women in the Western world. Alt...

442

Crop Management Factors: What is Important?  

E-print Network

Crop Management Factors: What is Important? Terry L. Kastens, Kevin C. Dhuyvetter, Heather Nivens and Danny Klinefelter* Defining Good Farm Management Economically, a well-managed farm is one that consistently makes greater prof- its than similarly...

Kastens, Terry L.; Dhuyvetter, Kevin C.; Nivens, Heather; Klinefelter, Danny A.

1999-09-29

443

NASA information sciences and human factors program  

NASA Technical Reports Server (NTRS)

The FY 1988 descriptions of technical accomplishments is presented in seven sections: Automation and Robotics, Communications Systems, Computer Sciences, Controls and Guidance, Data Systems, Human Factors, and Sensor Technology.

Holcomb, Lee; Hood, Ray; Montemerlo, Melvin; Sokoloski, Martin; Jenkins, James; Smith, Paul; Dibattista, John

1989-01-01

444

Convex nonnegative matrix factorization with manifold regularization.  

PubMed

Nonnegative Matrix Factorization (NMF) has been extensively applied in many areas, including computer vision, pattern recognition, text mining, and signal processing. However, nonnegative entries are usually required for the data matrix in NMF, which limits its application. Besides, while the basis and encoding vectors obtained by NMF can represent the original data in low dimension, the representations do not always reflect the intrinsic geometric structure embedded in the data. Motivated by manifold learning and Convex NMF (CNMF), we propose a novel matrix factorization method called Graph Regularized and Convex Nonnegative Matrix Factorization (GCNMF) by introducing a graph regularized term into CNMF. The proposed matrix factorization technique not only inherits the intrinsic low-dimensional manifold structure, but also allows the processing of mixed-sign data matrix. Clustering experiments on nonnegative and mixed-sign real-world data sets are conducted to demonstrate the effectiveness of the proposed method. PMID:25523040

Hu, Wenjun; Choi, Kup-Sze; Wang, Peiliang; Jiang, Yunliang; Wang, Shitong

2015-03-01

445

EXPOSURE FACTORS HANDBOOK - EXTERNAL REVIEW DRAFT  

EPA Science Inventory

The document provides a summary of the available data on various factors used in assessing human exposure including drinking water consumption; consumption rates of broad classes of food including fruits, vegetables, beef, dairy products, and fish; soil ingestion; inhalation rate...

446

NEW EFFICIENT AND ROBUST HSS CHOLESKY FACTORIZATION ...  

E-print Network

In this paper, we propose a robust Cholesky factorization method for symmetric pos- itive definite ... Recently, Xia and Gu have proposed an efficient algorithm that computes ..... Identify the ith diagonal block Atiti and ith HSS block row. Hrow.

2012-04-23

447

Factors favorable to public participation success  

SciTech Connect

Categories of factors linked to successful public participation (PP) program outcomes include PP process, organizational context, sociopolitical context, strategic considerations and unique (special circumstances) factors. We re-order the long list factors according to how essential, important, and unique they are and discuss their significance and interrelationships. It is argued that bureacratic structure and operational modes are basically in conflict with features of successful PP programs (openness, two-way education, communication with nonexpert outsiders). If this is so, then it is not surprising that the factors essential for PP success in bureacracies involve extraordinary management efforts by agencies to bypass, compensate for, or overcome structural constraints. We conclude by speculating about the long-term viability of PP practices in the agency setting as well as the consequences for agencies that attempt the problematic task of introducing PP into their complex, mission-oriented organizations.

Peelle, E.; Schweitzer, M.; Munro, J.; Carnes, S.; Wolfe, A.

1996-05-01

448

Repairing Tom Swift's electric factor analysis machine  

E-print Network

Proper use of exploratory factor analysis (EFA) requires the researcher to make a series of careful decisions. Despite attempts by Floyd and Widaman (1995), Fabrigar, Wegener, MacCallum, and Strahan (1999), and others to ...

Preacher, K. J.; MacCallum, R. C.

2003-01-01

449

14 CFR 29.621 - Casting factors.  

...Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...support structural loads. (b) Bearing stresses and surfaces. The casting factors...exceed 1.25 with respect to bearing stresses regardless of the method of...

2014-01-01

450

14 CFR 27.621 - Casting factors.  

...Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION AIRCRAFT...support structural loads. (b) Bearing stresses and surfaces. The casting factors...exceed 1.25 with respect to bearing stresses regardless of the method of...

2014-01-01

451

New Clue Found to Growth Factor Action.  

ERIC Educational Resources Information Center

Discussed is the discovery which may help to explain epidermal growth factor effects on the cell skeleton. The role of a protein called profilin in the regulation of the microfilament system is described. (CW)

Hoffman, Michelle

1991-01-01

452

Factorizations of some weighted spanning tree enumerators  

E-print Network

We give factorizations for weighted spanning tree enumerators of Cartesian products of complete graphs, keeping track of fine weights related to degree sequences and edge directions. Our methods combine Kirchhoff's ...

Martin, Jeremy L.; Reiner, Victor

2003-11-01

453

Recombination Clumping Factor during Cosmic Reionization  

NASA Astrophysics Data System (ADS)

We discuss the role of recombinations in the intergalactic medium, and the related concept of the clumping factor, during cosmic reionization. The clumping factor is, in general, a local quantity that depends on both the local overdensity and the scale below which the baryon density field can be assumed smooth. That scale, called the filtering scale, depends on over-density and local thermal history. We present a method for building a self-consistent analytical model of inhomogeneous reionization, assuming the linear growth rate of the density fluctuation, which simultaneously accounts for these effects. We show that taking into account the local clumping factor introduces significant corrections to the total recombination rate, compared to the model with a globally uniform clumping factor.

Kaurov, Alexander A.; Gnedin, Nickolay Y.

2014-06-01

454

7 CFR 3415.15 - Evaluation factors.  

Code of Federal Regulations, 2010 CFR

...BIOTECHNOLOGY RISK ASSESSMENT RESEARCH GRANTS PROGRAM Scientific Peer Review of Research Grant Applications § 3415.15 Evaluation...factors. In carrying out its review under § 3415.14, the peer review group will take into account the following...

2010-01-01

455

Acidic Fibroblast Growth Factor Promotes Vascular Repair  

NASA Astrophysics Data System (ADS)

Intravascular injury to arteries can result in thickening of the intimal smooth muscle layer adjacent to the lumen by migration and proliferation of cells from the underlying medial smooth muscle layer accompanied by deposition of extracellular matrix. This pathological response, which decreases lumen diameter, might, in part, be the result of the access of smooth muscle cells to plasma and platelet-derived growth factors as a consequence of denudation of the overlying confluent monolayer of vascular endothelial cells. Injured rat carotid arteries were treated by i.v. administration of acidic fibroblast growth factor, a heparin-binding protein that is chemotactic and mitogenic for vascular endothelial cells. The growth factor treatment resulted in dose-dependent inhibition of intimal thickening with parallel promotion of endothelial regeneration over the injured area. Therefore, acidic fibroblast growth factor might be efficacious in the prevention of restenosis caused by intimal thickening following angioplasty in humans.

Bjornsson, Thorir D.; Dryjski, Maciej; Tluczek, John; Mennie, Robert; Ronan, John; Mellin, Theodore N.; Thomas, Kenneth A.

1991-10-01

456

Factors that influence women's health in Tanzania.  

PubMed

A descriptive account of factors that influence women's health in Tanzania is given. The social and cultural processes that enhance or undermine women's health are emphasized. Recommendations for changes to improve women's health are made. PMID:8169170

Lugina, H I

1994-01-01

457

DEVELOPMENT AND SELECTION OF AMMONIA EMISSION FACTORS  

EPA Science Inventory

This report compiles recent literature on ammonia (NH') emission factors for application in the United States. ost of the recent research supports acid deposition studies in the European community (specifically, the Netherlands, Great Britain, and Scandinavia) but some research h...

458

Rice Quality Factors: Implications For Management Decisions.  

E-print Network

. Review comments and suggestions from Bill Black, Bart Drees, Arthur Gerlow, Melvin Parker, James Stansel, Mo Way, Bill Webb, and Michael Wohlgenant are also appreciated. A special thanks to Kim Trant for editorial assistance. ... Rice Quality Factors...

Grant, Warren R.; Rister, Edward, M.; Brorsen, B. Wade

1986-01-01

459

Cervical Artery Dissection: Emerging Risk Factors  

PubMed Central

Cervical artery dissection (CAD) represents an increasingly recognized cause of stroke and the most common cause of ischemic stroke in young adults. Many factors have been identified in association with CAD such as primary disease of arterial wall (fibrodysplasia) and other non-specific diseases related to CAD like Ehlers Danlos-syndrome IV, Marfan’s syndrome, vessel tortuosity. Moreover, an underlying arteriopathy which could be in part genetically determined, has been suspected. The rule of emerging risk factors for CAD such as recent respiratory tract infection, migraine and hyperhomocysteinemia are still a matter of research. Other known risks factors for CAD are major head/neck trauma like chiropractic maneuver, coughing or hyperextension injury associated to car. We examined emerging risks factors for CAD detected in the last years, as CAD pathogenesis is still not completely understood and needs further investigations. PMID:21270941

Micheli, S; Paciaroni, M; Corea, F; Agnelli, G; Zampolini, M; Caso, V

2010-01-01

460

[Midwives' perception of reproductive risk factors].  

PubMed

Midwives in rural areas of the State of Morelos are one of the most important resources used by rural women for health care of pregnancy, delivery and the puerperium. This work was aimed at identifying midwives perceptions of pregnant women's risk factors, in order to include this knowledge in reproductive health programs which articulate institutional and traditional health systems. We applied a questionnaire to all midwives in the Municipalities of Ocuituco, yecapixtla and Zacualpan, Morelos (n = 35). Four key informants were selected and interviewed. These instruments enabled us to measure variability in perception of risk factors. Knowledge of risk factors is defective among midwives. Previous training made a big difference. Sixty three per cent of midwives who attended training courses are better qualified from an academic medicine point of view. Only 28.7 per cent of non-trained midwives (43% for both groups), indicating that sociocultural aspects prevail over technical training in midwives perceptions of reproductive risk factors. PMID:8470023

García-Barrios, C; Castańeda-Camey, X; Romero-Guerrero, X; González-Hernández, D; Langer-Glas, A

1993-01-01

461

Decision making process and factors routing  

E-print Network

This research studies the decision-making process and the factors that affect truck routing. The data collection involved intercept interviews with truck drivers at three rest area and truck stops along major highways in ...

Sun, Yichen, S.M. Massachusetts Institute of Technology

2013-01-01

462

7 CFR 29.2551 - Special factor.  

Code of Federal Regulations, 2010 CFR

...REGULATIONS TOBACCO INSPECTION Standards Official Standard Grades for Kentucky and Tennessee Fire-Cured and Foreign-Grown Fire-Cured Tobacco (u.s. Types 22, 23, and Foreign Type 96) § 29.2551 Special factor. A...

2010-01-01

463

Overweight cats: prevalence and risk factors.  

PubMed

Body condition was assessed by owners and veterinarians for over 2000 cats presented to 31 private veterinary hospitals in the Northeastern United States. Each owner completed a questionnaire querying potential factors associated with his/her cat's body condition. Veterinarians reported twenty-five percent of cats were overweight (heavy or obese), while owners estimated 29% of their pets were overweight. Apartment dwelling, inactivity, middle age, being male, neutered, of mixed breeding, and certain dietary factors were associated with being overweight. PMID:8087161

Scarlett, J M; Donoghue, S; Saidla, J; Wills, J

1994-06-01

464

Electromagnetic Form Factors of Meson Transitions  

NASA Astrophysics Data System (ADS)

Within the Dyson-Schwinger equation approach to modeling QCD for meson physics, we present new results for grpp and the coupling constants and form factors for the transitions g* pr and g* p0 g. We discuss the role of the sub-dominant covariants of the p Bethe-Salpeter amplitude and investigate the asymptotic behavior of the g* p0 g form factor.

Tandy, Peter C.

465

Factors Influencing the Fatigue Strength of Materials  

NASA Technical Reports Server (NTRS)

A number of factors are considered which influence the static and fatigue strength of materials under practical operating conditions as contrasted with the relations obtaining under conditions of the usual testing procedure. Such factors are interruptions in operation, periodically fluctuating stress limits and mean stresses with periodic succession of several groups and stress states, statistical changes and succession of stress limits and mean stresses, frictional corrosion at junctures, and notch effects.

Bollenrath, F

1941-01-01

466

Classical strongly coupled QGP: VI. Structure Factors  

E-print Network

We show that the classical and strongly coupled QGP (cQGP) is characterized by a multiple of structure factors that obey generalized Orstein-Zernicke equations. We use the canonical partition function and its associated density functional to derive analytical equations for the density and charge monopole structure factors for arbitrary values of $\\Gamma=V/K$, the ratio of the mean potential to Coulomb energy. The results are compared with SU(2) molecular dynamics simulations.

Sungtae Cho; Ismail. Zahed

2009-09-25

467

Risk Factors for Homelessness among Women Veterans  

Microsoft Academic Search

:Background. Women veterans are three to four times more likely than non-veteran women to become homeless. However, their risk factors for homelessness have not been defined. Methods. Case-control study of non-institutionalized homeless women veterans (n533) and age-matched housed women veterans (n=165). Health, health care, and factors associated with homelessness were assessed using multiple logistic regression with a Monte Carlo algorithm

Donna L. Washington; Elizabeth M. Yano; James McGuire; Vivian Hines; Martin Lee; Lillian Gelberg

2010-01-01

468

Risk Factors for Homelessness among Women Veterans  

Microsoft Academic Search

Background. Women veterans are three to four times more likely than non-veteran women to become homeless. However, their risk factors for homelessness have not been defined. Methods. Case-control study of non-institutionalized homeless women veterans (n533) and age-matched housed women veterans (n=165). Health, health care, and factors associated with homelessness were assessed using multiple logistic regression with a Monte Carlo algorithm

MPH Elizabeth M. Yano MSPH Donna L. Washington; MSPH Lillian Gelberg

2010-01-01

469

Pathophysiologic factors in recurrent acute pancreatitis  

Microsoft Academic Search

No single pathophysiologic factor has been identified as the cause of recurrent acute pancreatitis. A systematic search should\\u000a be undertaken in every patient to identify one of a myriad of factors that have been shown to play a part in causing this\\u000a distressing illness. The abuse of alcohol remains the likeliest cause, and further research may reveal an inborn error

Larry C. Carey

1985-01-01

470

The Corona Factorization Property and Refinement Monoids  

Microsoft Academic Search

The Corona Factorization Property of a C*-algebra, originally defined to study extensions of C*-algebras, has turned out to say something important about intrinsic structural properties of the C*-algebra. We show in this paper that a \\\\sigma-unital C*-algebra A of real rank zero has the Corona Factorization roperty if and only if its monoid V(A) of Murray-von Neumann equivalence classes of

Eduard Ortega; Francesc Perera; Mikael Rordam

2009-01-01

471

Risk Factors for Injuries in Football  

Microsoft Academic Search

Background: The injury risk in football is high, but little is known about causes of injury.Purpose: To identify risk factors for football injuries using a multivariate model.Study Design: Prospective cohort study.Methods: Participants were 306 male football players from the two highest divisions in Iceland. Before the 1999 football season started, the following factors were examined: height, weight, body composition, flexibility,

Arni Arnason; Stefan B. Sigurdsson; Arni Gudmundsson; Ingar Holme; Lars Engebretsen; Roald Bahr

2004-01-01

472

Motor and perceptual factors in pseudoneglect  

Microsoft Academic Search

An important variant of the traditional line bisection task has involved a mechanical device invented by Bisiach and his colleagues (Bisiach et al. Perceptual and premotor factors of unilateral neglect. Neurology 1990;40:1278–81 [3]). This tool was devised to dissociate motor from perceptual factors in hemi-spatial neglect, by means of a mid-line indicator which moved congruently or non-congruently with the direction

Mairi S MacLeod; Oliver H Turnbull

1999-01-01

473

Factoring numbers with a single interferogram  

SciTech Connect

We construct an analog computer based on light interference to encode the hyperbolic function f({zeta}){identical_to}1/{zeta} into a sequence of skewed curlicue functions. The resulting interferogram when scaled appropriately allows us to find the prime number decompositions of integers. We implement this idea exploiting polychromatic optical interference in a multipath interferometer and factor seven-digit numbers. We give an estimate for the largest number that can be factored by this scheme.

Tamma, Vincenzo [Department of Physics, University of Maryland, Baltimore County, Baltimore, Maryland 21250 (United States); Dipartimento Interateneo di Fisica, Universita degli Studi di Bari, IT-70100 Bari (Italy); Zhang Heyi; He Xuehua; Shih Yanhua [Department of Physics, University of Maryland, Baltimore County, Baltimore, Maryland 21250 (United States); Garuccio, Augusto [Dipartimento Interateneo di Fisica, Universita degli Studi di Bari, IT-70100 Bari (Italy); INFN-Sezione di Bari, Bari (Italy); Schleich, Wolfgang P. [Institut fuer Quantenphysik, Universitaet Ulm, Albert-Einstein-Allee 11, D-89081 Ulm (Germany)

2011-02-15

474

Effects of Urbanization Factors on Model Parameters  

Microsoft Academic Search

This study mainly explores effects of urbanization factors on hydrograph parameters. Urbanization impacts of the developing\\u000a watershed are evaluated based on rainfall–runoff simulations. A total of 51 rainfall–runoff events occurred from 1966 to 2002.\\u000a Forty of these were calibrated, and effects of urbanization factors on runoff hydrographs resulting from a simple hydrological\\u000a model were assessed. The block Kriging method was

Shin-jen Cheng; Cheng-feng Lee; Ju-huang Lee

2010-01-01

475

Nerve Growth Factor and Diabetic Neuropathy  

PubMed Central

Neuropathy is one of the most debilitating complications of both type 1 and type 2 diabetes, with estimates of prevalence between 50–90% depending on the means of detection. Diabetic neuropathies are heterogeneous and there is variable involvement of large myelinated fibers and small, thinly myelinated fibers. Many of the neuronal abnormalities in diabetes can be duplicated by experimental depletion of specific neurotrophic factors, their receptors or their binding proteins. In experimental models of diabetes there is a reduction in the availability of these growth factors, which may be a consequence of metabolic abnormalities, or may be independent of glycemic control. These neurotrophic factors are required for the maintenance of the neurons, the ability to resist apoptosis and regenerative capacity. The best studied of the neurotrophic factors is nerve growth factor (NGF) and the related members of the neurotrophin family of peptides. There is increasing evidence that there is a deficiency of NGF in diabetes, as well as the dependent neuropeptides substance P (SP) and calcitonin gene-related peptide (CGRP) that may also contribute to the clinical symptoms resulting from small fiber dysfunction. Similarly, NT3 appears to be important for large fiber and IGFs for autonomic neuropathy. Whether the observed growth factor deficiencies are due to decreased synthesis, or functional, e.g. an inability to bind to their receptor, and/or abnormalities in nerve transport and processing, remains to be established. Although early studies in humans on the role of neurotrophic factors as a therapy for diabetic neuropathy have been unsuccessful, newer agents and the possibilities uncovered by further studies should fuel clinical trials for several generations. It seems reasonable to anticipate that neurotrophic factor therapy, specifically targeted at different nerve fiber populations, might enter the therapeutic armamentarium. PMID:14668049

Vinik, Aaron

2003-01-01

476

Factoring: A Visual Representation of Number  

NSDL National Science Digital Library

This Focus on Math blog post presents a dot diagram by Brent Yorgey of the consecutive natural numbers. The configuration of each number of dots reveals quickly whether it is prime or composite and provides information about its prime factorization. Included are two links: one to Stephen Von Wordley's animated factorization diagrams and the other to Malke Rosenfeld's blog describing a game based on the diagram.

Norris, Carollee

2013-01-08

477

Nucleon electromagnetic form factors with Wilson fermions  

E-print Network

The nucleon electromagnetic form factors continue to be of major interest for experimentalists and phenomenologists alike. They provide important insights into the structure of nuclear matter. For a range of interesting momenta they can be calculated on the lattice. The limiting factor continues to be the value of the pion mass. We present the latest results of the QCDSF collaboration using gauge configurations with two dynamical, non-perturbatively improved Wilson fermions at pion masses as low as 350 MeV.

M. Gockeler; Ph. Hagler; R. Horsley; Y. Nakamura; M. Ohtani; D. Pleiter; P. E. L. Rakow; A. Schafer; G. Schierholz; W. Schroers; H. Stuben; J. M. Zanotti

2007-10-11

478

Autocrine Growth Factor Signaling in Motility  

Microsoft Academic Search

The objective of this chapter is to summarize our current understanding of the role of growth factor autocrine signaling in\\u000a cell motility. The Epidermal Growth Factor Receptor (EGFR) was chosen as a central example system for motivating autocrine\\u000a operation as important in both normal physiological processes as well as pathological conditions such as cancer. We provide\\u000a specific evidence from research

Elizabeth J. Joslin; Douglas A. Lauffenburger

479

The neutrino charge form-factor  

NASA Technical Reports Server (NTRS)

Mathematical analysis and dispersion relations are used to obtain the general functional form of the neutrino charge form-factor. It is shown that if the scale for weak interactions is given by G, where G is the Fermi coupling constant, then for a large range of momentum transfer values, the form-factor may be approximated by a function that is linear in the square of the momentum transfer.

Mickens, R. E.

1975-01-01

480

Ionizing radiation: a risk factor for mesothelioma  

Microsoft Academic Search

In the majority of mesothelioma cases worldwide, asbestos is a likely causal factor, but several alternative factors, such\\u000a as ionizing radiation, have been recognized. We reviewed ionizing-radiation evidence from epidemiology studies of (1) patients\\u000a exposed to the diagnostic X-ray contrast medium “Thorotrast,” (2) patients undergoing radiation therapy (i.e., to treat cancer),\\u000a and (3) atomic energy workers chronically exposed to lower

Julie E. Goodman; Marc A. Nascarella; Peter A. Valberg

2009-01-01

481

Factors affecting the nutritive value of bermudagrasses  

E-print Network

FACTORS AFFECTING THE NUTRITIVE VALUE OF BERMUDAGRASSES A Thesis by Nilliam Aylmer Rainwater Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirement for the degree of MASTER OF SCIENCE December..., 1975 Major Subject: Animal Nutrition FACTORS AFFECTING THE NUTRITIVE VALUE OF BERMUDAGRASSES A Thesis by WILLIAM AYLMER RAINWATER Approved as to style and content by: , ~A; (' v'~ (Chairman of Committee) t-c-+ (Head of Departm t) d. ~ c . D...

Rainwater, William Aylmer

1975-01-01

482

Hormonal Factors and Pancreatic Cancer in Women  

Microsoft Academic Search

PURPOSE: The aim of the study was to evaluate hormonal risk factors for carcinoma of the exocrine pancreas among postmenopausal women.METHODS: Mailed questionnaire data from 52 cases and 233 population-based controls in Ontario were used to assess parity, age at first birth, and other hormonal factors on pancreatic cancer risk.RESULTS: Reduced risk was seen with three or more pregnancies [adjusted

Nancy Kreiger; Jeanie Lacroix; Margaret Sloan

2001-01-01

483

Growth factors in cartilage tissue engineering.  

PubMed

Tissue engineering of cartilage consists of two steps. Firstly, the cells from a small biopsy of patient's own tissue have to be multiplied. During this multiplication process they lose their cartilage phenotype. In the second step, these cells have to be stimulated to re-express their cartilage phenotype and produce cartilage matrix. Growth factors can be used to improve cell multiplication, redifferentiation and production of matrix. The choice of growth factors should be made for each phase of the tissue engineering process separately, taking into account cell phenotype and the presence of extracellular matrix. This paper demonstrates some examples of the use of growth factors to increase the amount, the quality and the assembly of the matrix components produced for cartilage tissue engineering. In addition it shows that the "culture history" (e.g., addition of growth factors during cell multiplication or preculture period in a 3-dimensional environment) of the cells influences the effect of growth factor addition. The data demonstrate the potency as well as the limitations of the use of growth factors in cartilage tissue engineering. PMID:12082284

van Osch, Gerjo J V M; Mandl, Erik W; Marijnissen, Willem J C M; van der Veen, Simone W; Verwoerd-Verhoef, Henriette L; Verhaar, Jan A N

2002-01-01

484

Risk Factors for Homelessness Among US Veterans.  

PubMed

Homelessness among US veterans has been a focus of research for over 3 decades. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, this is the first systematic review to summarize research on risk factors for homelessness among US veterans and to evaluate the evidence for these risk factors. Thirty-one studies published from 1987 to 2014 were divided into 3 categories: more rigorous studies, less rigorous studies, and studies comparing homeless veterans with homeless nonveterans. The strongest and most consistent risk factors were substance use disorders and mental illness, followed by low income and other income-related factors. There was some evidence that social isolation, adverse childhood experiences, and past incarceration were also important risk factors. Veterans, especially those who served since the advent of the all-volunteer force, were at greater risk for homelessness than other adults. Homeless veterans were generally older, better educated, and more likely to be male, married/have been married, and to have health insurance coverage than other homeless adults. More studies simultaneously addressing premilitary, military, and postmilitary risk factors for veteran homelessness are needed. This review identifies substance use disorders, mental illness, and low income as targets for policies and programs in efforts to end homelessness among veterans. PMID:25595171

Tsai, Jack; Rosenheck, Robert A

2015-01-01

485

Organizational safety factors research lessons learned  

SciTech Connect

This Paper reports lessons learned and state of knowledge gained from an organizational factors research activity involving commercial nuclear power plants in the United States, through the end of 1991, as seen by the scientists immediately involved in the research. Lessons learned information was gathered from the research teams and individuals using a question and answer format. The following five questions were submitted to each team and individual: (1) What organizational factors appear to influence safety performance in some systematic way, (2) Should organizational factors research focus at the plant level, or should it extend beyond the plant level to the parent company, rate setting commissions, regulatory agencies, (3) How important is having direct access to plants for doing organizational factors research, (4) What lessons have been learned to date as the result of doing organizational factors research in a nuclear regulatory setting, and (5) What organizational research topics and issues should be pursued in the future? Conclusions based on the responses provided for this report are that organizational factors research can be conducted in a regulatory setting and produce useful results. Technologies pioneered in other academic, commercial, and military settings can be adopted for use in a nuclear regulatory setting. The future success of such research depends upon the cooperation of regulators, contractors, and the nuclear industry.

Ryan, T.G.

1995-10-01

486

[The role of angiogenic factors in preeclampsia].  

PubMed

Preeclampsia is one of the most common and most serious complications of pregnancy and the management of this condition still challenges obstetricians. Despite intensive research the etiology of preeclampsia still remains unclear. At the beginning of the 2000s preeclampsia-related research was directed towards factors that influence angiogenesis. Most studies have been carried out on the placental growth factor and soluble fms-like tyrosine kinase-1. Most publications confirm the increased concentrations of antiangiogenic factors and decreased concentrations of proangiogenic factors in maternal blood samples in preeclampsia even before the onset of clinical symptoms. According to our current knowledge antiangiogenic proteins are responsible for the endothelial dysfunction in the symptomatic stage of the disease. Placental growth factor and soluble fms-like tyrosine kinase-1 may have important roles in the prediction and treatment of the disease. The point of care detection of placental growth factor and soluble fms-like tyrosine kinase-1 may be used to predict preeclampsia. Rapid tests are available to determine the serum levels of the two proteins. Removal of soluble fms-like tyrosine kinase-1 from maternal circulation is a potential treatment option for early onset preeclampsia. PMID:25403279

Alasztics, Bálint; Gullai, Nóra; Molvarec, Attila; Rigó, János

2014-11-23

487

Peripheral nerve regeneration and neurotrophic factors  

PubMed Central

The role of neurotrophic factors in the maintenance and survival of peripheral neuronal cells has been the subject of numerous studies. Administration of exogenous neurotrophic factors after nerve injury has been shown to mimic the effect of target organ-derived trophic factors on neuronal cells. After axotomy and during peripheral nerve regeneration, the neurotrophins NGF, NT-3 and BDNF show a well defined and selective beneficial effect on the survival and phenotypic expression of primary sensory neurons in dorsal root ganglia and of motoneurons in spinal cord. Other neurotrophic factors such as CNTF, GDNF and LIF also exert a variety of actions on neuronal cells, which appear to overlap and complement those of the neurotrophins. In addition, there is an indirect contribution of GGF to nerve regeneration. GGF is produced by neurons and stimulates proliferation of Schwann cells, underlining the close interaction between neuronal and glial cells during peripheral nerve regeneration. Different possibilities have been investigated for the delivery of growth factors to the injured neurons, in search of a suitable system for clinical applications. The studies reviewed in this article show the therapeutic potential of neurotrophic factors for the treatment of peripheral nerve injury and for neuropathies. PMID:10227662

TERENGHI, GIORGIO

1999-01-01

488

Stroke in Bangladeshi patients and risk factor.  

PubMed

To evaluate comprehensively the distribution of established risk factors of stroke among Bangladeshi patients. This is an observational study. It involved 8400 stroke patients from different hospitals in Bangladesh over a period of sixteen years. Common established risk factors of stroke e.g. age, sex, family history, hypertension, diabetes, ischemic heart disease, smoking, obesity, dyslipidaemia, alcoholism, use of oral contraceptive pill, lack of fresh fruit consumption etc. were evaluated in these patients through a preformed questionnaire and data were analyzed. Majority of the stroke events occurred after the age of forty (82.3%) and the ischemic stroke (72%) is the most common. Apart from non modifiable risk factors (advancing age, sex, Family history of stroke) hypertension was the most common modifiable risk factor found in stroke patients (57.6%) followed by smoking (44.6%), tobacco use (24.3%), OCP use in female (40% of female stroke), diabetes (23%), ischemic heart disease (17.1%), obesity (10.6%) and dyslipidaemia (5.3%). Lack of fresh fruit consumption and alcoholism were found in some of the patients. Stroke is common after the age of forty. Ischemic events are commonest type of stroke. Hypertension, smoking, tobacco use, diabetes and ischemic heart disease were five most common risk factors of stroke. Outlining the common stroke risk factors in our settings, may help the physicians and care givers in managing this disabling disease properly. PMID:25178605

Mohammad, Q D; Habib, M; Mondal, B A; Chowdhury, R N; Hasan, M H; Hoque, M A; Rahman, K M; Khan, S U; Chowdhury, A H; Haque, B

2014-07-01

489

On geometric factors for neutral particle analyzers  

NASA Astrophysics Data System (ADS)

Neutral particle analyzers (NPA) detect neutralized energetic particles that escape from plasmas. Geometric factors relate the counting rate of the detectors to the intensity of the particle source. Accurate geometric factors enable quick simulation of geometric effects without the need to resort to slower Monte Carlo methods. Previously derived expressions [G. R. Thomas and D. M. Willis, "Analytical derivation of the geometric factor of a particle detector having circular or rectangular geometry," J. Phys. E: Sci. Instrum. 5(3), 260 (1972); J. D. Sullivan, "Geometric factor and directional response of single and multi-element particle telescopes," Nucl. Instrum. Methods 95(1), 5-11 (1971)] for the geometric factor implicitly assume that the particle source is very far away from the detector (far-field); this excludes applications close to the detector (near-field). The far-field assumption does not hold in most fusion applications of NPA detectors. We derive, from probability theory, a generalized framework for deriving geometric factors that are valid for both near and far-field applications as well as for non-isotropic sources and nonlinear particle trajectories.

Stagner, L.; Heidbrink, W. W.

2014-11-01

490

On geometric factors for neutral particle analyzers.  

PubMed

Neutral particle analyzers (NPA) detect neutralized energetic particles that escape from plasmas. Geometric factors relate the counting rate of the detectors to the intensity of the particle source. Accurate geometric factors enable quick simulation of geometric effects without the need to resort to slower Monte Carlo methods. Previously derived expressions [G. R. Thomas and D. M. Willis, "Analytical derivation of the geometric factor of a particle detector having circular or rectangular geometry," J. Phys. E: Sci. Instrum. 5(3), 260 (1972); J. D. Sullivan, "Geometric factor and directional response of single and multi-element particle telescopes," Nucl. Instrum. Methods 95(1), 5-11 (1971)] for the geometric factor implicitly assume that the particle source is very far away from the detector (far-field); this excludes applications close to the detector (near-field). The far-field assumption does not hold in most fusion applications of NPA detectors. We derive, from probability theory, a generalized framework for deriving geometric factors that are valid for both near and far-field applications as well as for non-isotropic sources and nonlinear particle trajectories. PMID:25430216

Stagner, L; Heidbrink, W W

2014-11-01

491

Influence of organizational factors on safety  

SciTech Connect

There is a need for a better understanding of exactly how organizational management factors at a nuclear power plant (NPP) affect plant safety performance, either directly or indirectly, and how these factors might be observed, measured, and evaluated. The purpose of this research project is to respond to that need by developing a general methodology for characterizing these organizational and management factors, systematically collecting information on their status and integrating that information into various types of evaluative activities. Research to date has included the development of the Nuclear Organization and Management Analysis Concept (NOMAC) of a NPP, the identification of key organizational and management factors, and the identification of the methods for systematically measuring and analyzing the influence of these factors on performance. Most recently, two field studies, one at a fossil fuel plant and the other at a NPP, were conducted using the developed methodology. Results are presented from both studies highlighting the acceptability, practicality, and usefulness of the methods used to assess the influence of various organizational and management factors including culture, communication, decision-making, standardization, and oversight. 6 refs., 3 figs., 1 tab.

Haber, S.B.; Metlay, D.S.; Crouch, D.A.

1990-01-01

492

Worldsheet factorization for twistor-strings  

NASA Astrophysics Data System (ADS)

We study the multiparticle factorization properties of two worldsheet theories which — at tree-level — describe the scattering of massless particles in four dimensions: the Berkovits-Witten twistor-string for = 4 super-Yang-Mills coupled to = 4 conformal supergravity, and the Skinner twistor-string for = 8 supergravity. By considering these string-like theories, we can study factorization at the level of the worldsheet before any Wick contractions or integrals have been performed; this is much simpler than considering the factorization properties of the amplitudes themselves. In Skinner's twistor-string this entails the addition of worldsheet gravity as well as a formalism that represents all external states in a manifestly symmetric way, which we develop explicitly at genus zero. We confirm that the scattering amplitudes of Skinner's theory, as well as the gauge theory amplitudes for the planar sector of the Berkovits-Witten theory, factorize appropriately at genus zero. In the non-planar sector, we find behavior indicative of conformal gravity in the Berkovits-Witten twistor-string. We contrast factorization in twistor-strings with the story in ordinary string theory, and also make some remarks on higher genus factorization and disconnected prescriptions.

Adamo, Tim

2014-04-01

493

Human Factors in Accidents Involving Remotely Piloted Aircraft  

NASA Technical Reports Server (NTRS)

This presentation examines human factors that contribute to RPA mishaps and provides analysis of lessons learned. RPA accident data from U.S. military and government agencies were reviewed and analyzed to identify human factors issues. Common contributors to RPA mishaps fell into several major categories: cognitive factors (pilot workload), physiological factors (fatigue and stress), environmental factors (situational awareness), staffing factors (training and crew coordination), and design factors (human machine interface).

Merlin, Peter William

2013-01-01

494

Modifiable risk factors for schizophrenia and autism--shared risk factors impacting on brain development.  

PubMed

Schizophrenia and autism are two poorly understood clinical syndromes that differ in age of onset and clinical profile. However, recent genetic and epidemiological research suggests that these two neurodevelopmental disorders share certain risk factors. The aims of this review are to describe modifiable risk factors that have been identified in both disorders, and, where available, collate salient systematic reviews and meta-analyses that have examined shared risk factors. Based on searches of Medline, Embase and PsycINFO, inspection of review articles and expert opinion, we first compiled a set of candidate modifiable risk factors associated with autism. Where available, we next collated systematic-reviews (with or without meta-analyses) related to modifiable risk factors associated with both autism and schizophrenia. We identified three modifiable risk factors that have been examined in systematic reviews for both autism and schizophrenia. Advanced paternal age was reported as a risk factor for schizophrenia in a single meta-analysis and as a risk factor in two meta-analyses for autism. With respect to pregnancy and birth complications, for autism one meta-analysis identified maternal diabetes and bleeding during pregnancy as risks factors for autism whilst a meta-analysis of eight studies identified obstetric complications as a risk factor for schizophrenia. Migrant status was identified as a risk factor for both autism and schizophrenia. Two separate meta-analyses were identified for each disorder. Despite distinct clinical phenotypes, the evidence suggests that at least some non-genetic risk factors are shared between these two syndromes. In particular, exposure to drugs, nutritional excesses or deficiencies and infectious agents lend themselves to public health interventions. Studies are now needed to quantify any increase in risk of either autism or schizophrenia that is associated with these modifiable environmental factors. PMID:23123588

Hamlyn, Jess; Duhig, Michael; McGrath, John; Scott, James

2013-05-01

495

Genetic Insights into Cardiometabolic Risk Factors  

PubMed Central

Many biochemical traits are recognised as risk factors, which contribute to or predict the development of disease. Only a few are in widespread use, usually to assist with treatment decisions and motivate behavioural change. The greatest effort has gone into evaluation of risk factors for cardiovascular disease and/or diabetes, with substantial overlap as ‘cardiometabolic’ risk. Over the past few years many genome-wide association studies (GWAS) have sought to account for variation in risk factors, with the expectation that identifying relevant polymorphisms would improve our understanding or prediction of disease; others have taken the direct approach of genomic case-control studies for the corresponding diseases. Large GWAS have been published for coronary heart disease and Type 2 diabetes, and also for associated biomarkers or risk factors including body mass index, lipids, C-reactive protein, urate, liver function tests, glucose and insulin. Results are not encouraging for personal risk prediction based on genotyping, mainly because known risk loci only account for a small proportion of risk. Overlap of allelic associations between disease and marker, as found for low density lipoprotein cholesterol and heart disease, supports a causal association, but in other cases genetic studies have cast doubt on accepted risk factors. Some loci show unexpected effects on multiple markers or diseases. An intriguing feature of risk factors is the blurring of categories shown by the correlation between them and the genetic overlap between diseases previously thought of as distinct. GWAS can provide insight into relationships between risk factors, biomarkers and diseases, with potential for new approaches to disease classification. PMID:24659834

Whitfield, John B

2014-01-01

496

Factors Affecting Intensive Care Units Nursing Workload  

PubMed Central

Background: The nursing workload has a close and strong association with the quality of services provided for the patients. Therefore, paying careful attention to the factors affecting nursing workload, especially those working in the intensive care units (ICUs), is very important. Objectives: This study aimed to determine the factors affecting nursing workload in the ICUs of the hospitals affiliated to Tehran University of Medical Sciences. Materials and Methods: This was a cross-sectional and analytical-descriptive study that has done in Iran. All nurses (n = 400) who was working in the ICUs of the hospitals affiliated to Tehran University of Medical Sciences in 2014 were selected and studied using census method. The required data were collected using a researcher–made questionnaire which its validity and reliability were confirmed through getting the opinions of experts and using composite reliability and internal consistency (? = 0.89). The collected data were analyzed through exploratory factor analysis (EFA), confirmatory factor analysis (CFA) and using SPSS 18.0 and AMOS 18.0. Results: Twenty-five factors were divided into three major categories through EFA, including structure, process, and activity. The following factors among the structure, process and activity components had the greatest importance: lack of clear responsibilities and authorities and performing unnecessary tasks (by a coefficient of 0.709), mismatch between the capacity of wards and the number of patients (by a coefficient of 0.639), and helping the students and newly employed staff (by a coefficient of 0.589). Conclusions: The nursing workload is influenced by many factors. The clear responsibilities and authorities of nurses, patients' admission according to the capacity of wards, use of the new technologies and equipment, and providing basic training for new nurses can decrease the workload of nurses. PMID:25389493

Bahadori, Mohammadkarim; Ravangard, Ramin; Raadabadi, Mehdi; Mosavi, Seyed Masod; Gholami Fesharaki, Mohammad; Mehrabian, Fardin

2014-01-01

497

Odd orders in Shor's factoring algorithm  

NASA Astrophysics Data System (ADS)

Shor's factoring algorithm (SFA) finds the prime factors of a number, $N=p_1 p_2$, exponentially faster than the best known classical algorithm. Responsible for the speed-up is a subroutine called the quantum order finding algorithm (QOFA) which calculates the order -- the smallest integer, $r$, satisfying $a^r \\mod N =1$, where $a$ is a randomly chosen integer coprime to $N$ (meaning their greatest common divisor is one, $\\gcd(a, N) =1$). Given $r$, and with probability not less than $1/2$, the factors are given by $p_1 = \\gcd (a^{\\frac{r}{2}} - 1, N)$ and $p_2 = \\gcd (a^{\\frac{r}{2}} + 1, N)$. For odd $r$ it is assumed the factors cannot be found (since $a^{\\frac{r}{2}}$ is not generally integer) and the QOFA is relaunched with a different value of $a$. But a recent paper [E. Martin-Lopez: Nat Photon {\\bf 6}, 773 (2012)] noted that the factors can sometimes be found from odd orders if the coprime is square. This raises the question of improving SFA's success probability by considering odd orders. We show that an improvement is possible, though it is small. We present two techniques for retrieving the order from apparently useless runs of the QOFA: not discarding odd orders; and looking out for new order finding relations in the case of failure. In terms of efficiency, using our techniques is equivalent to avoiding square coprimes and disregarding odd orders, which is simpler in practice. Even still, our techniques may be useful in the near future, while demonstrations are restricted to factoring small numbers. The most convincing demonstrations of the QOFA are those that return a non-power-of-two order, making odd orders that lead to the factors attractive to experimentalists.

Lawson, Thomas

2015-01-01

498

Human platelet surface binding of endogenous secreted factor VIII-von Willebrand factor and platelet factor 4  

SciTech Connect

Washed human platelets in buffers containing either 2 mM Ca++ or 4 mM EDTA were stimulated by human alpha-thrombin to induce secretion. The binding of two endogenous secreted proteins, factor-VIII-related protein (VIII-R) (von Willebrand factor) and platelet factor 4, was measured by reacting thrombin-treated and control platelets with specific antibodies to these proteins, then quantifying antibody binding with /sup 125/I-staphylococcal protein A. Both of these granule proteins were associated with the platelet membrane surface by a calcium-dependent mechanism after thrombin-induced secretion. This ability to bind endogenous secreted proteins to the plasma membrane surface may provide a mechanism by which the platelet can concentrate and organize its secreted proteins for subsequent physiologic reactions.

George, J.N.; Onofre, A.R.

1982-01-01

499

Factor Analysis for Skewed Data and Skew-Normal Maximum Likelihood Factor Analysis  

E-print Network

FACTOR ANALYSIS FOR SKEWED DATA AND SKEW-NORMAL MAXIMUM LIKELIHOOD FACTOR ANALYSIS A Dissertation by BEVERLY JANE GAUCHER Submitted to the Office of Graduate Studies of Texas A&M University in partial fulfillment of the requirements... Beverly Jane Gaucher ABSTRACT This research explores factor analysis applied to data from skewed distributions for the general skew model, the selection-elliptical model, the selection-normal model, the skew-elliptical model and the skew-normal model...

Gaucher, Beverly Jane

2013-04-04

500

Keratinocyte growth factor and hepatocyte growth factor/scatter factor are heparin-binding growth factors for alveolar type II cells in fibroblast-conditioned medium.  

PubMed Central

Epithelial-mesenchymal interactions mediate aspects of normal lung growth and development and are important in the restoration of normal alveolar architecture after lung injury. To determine if fibroblasts are a source of soluble growth factors for alveolar type II cells, we investigated the effect of fibroblast-conditioned medium (CM) on alveolar type II cell DNA synthesis. Serum-free CM from confluent adult human lung fibroblasts was concentrated fivefold by lyophilization. Type II cells were isolated from adult rats by elastase dissociation and incubated with [3H]thymidine and varying dilutions of concentrated CM and serum from day 1 to 3 of culture. Stimulation of type II cell DNA synthesis by fibroblast-CM was maximal after 48 h of conditioning and required the presence of serum. The activity of the CM was eliminated by boiling and by treatment with trypsin, pepsin, or dithiothreitol and was additive with saturating concentrations of acidic fibroblast growth factor, epidermal growth factor, and insulin. The growth factor activity bound to heparin-Sepharose and was eluted with 0.6 and 1.0 M NaCl. Neutralizing antibody studies demonstrated that the primary mitogens isolated in the 0.6 and 1.0 M NaCl fractions were keratinocyte growth factor (KGF, fibroblast growth factor 7) and hepatocyte growth factor/scatter factor (HGF/SF), respectively. HGF/SF was demonstrated in the crude CM and KGF was detected in the 0.6 M NaCl eluent by immunoblotting. Northern blot analysis confirmed that the lung fibroblasts expressed both KGF and HGF/SF transcripts. Human recombinant KGF and HGF/SF induced a concentration- and serum-dependent increase in rat alveolar type II cell DNA synthesis. We conclude that adult human lung fibroblasts produce at least two soluble heparin-binding growth factors, KGF and HGF/SF, which promote DNA synthesis and proliferation of rat alveolar type II cells in primary culture. KGF and HGF/SF may be important stimuli for alveolar type II cell proliferation during lung growth and after lung injury. Images PMID:7688769

Panos, R J; Rubin, J S; Csaky, K G; Aaronson, S A; Mason, R J

1993-01-01