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1

RIESGO DE SUICIDIO EN PRISIÓN Y FACTORES ASOCIADOS: UN ESTUDIO EXPLORATORIO EN CINCO CENTROS PENALES DE BOGOTÁ 1  

Microsoft Academic Search

Suicide risk in prison is a important theme of penitentiary politics agenda, because prisoners suicide rates are frequently highers than in general population. In according to research, suicide behaviors are more frequents in youth prisoners, drug abusers, people with previous mental diseases, but not with depression. Also, both legal process difficulties and imprisonment variables are risk factors of self-damage, like

José Ignacio Ruiz; Ingrid Gómez; Mary Luz Landazabal; Sully Morales; Vanessa Sánchez; Darío Páez; Revista Colombiana de Psicología

2002-01-01

2

Factoring  

NSDL National Science Digital Library

Test your factoring skills Factors and Multiples Jeopardy How much do you know about factoring and multiples? Play Jeopardy and find out! Prime Factoring Turkey Shoot Blast these turkeys using your factoring skills. Help the Professor Super save the planet by "cooking" the Giant Frozen Turkeys of Destruction. Math Lines 12 X-Factor Shoot the ball at the other factors to get a product of 12. You can also ...

Clark, Mr

2012-10-31

3

Factorize  

NSDL National Science Digital Library

This interactive Java applet helps students explore the relationship between area and multiplication. First, users are asked to input all factor pairs of a given number. Then, selecting each of those factor pairs, the user draws the respective rectangular array by clicking and dragging across a grid. Options include the use of the commutative property (e.g., user must enter both 2x4 and 4x2 for factors of 8 and represent them with different arrays), entering a number of the user's own choice, and an optional scoring feature allowing the user to keep track of the number correct.

2004-01-01

4

Composition and structure of fish assemblage from Passa Cinco stream, Corumbataí river sub-basin, SP, Brazil.  

PubMed

The aim of this work was to determine the composition of the fish assemblage of Passa Cinco stream and verify changes in their structure on the altitudinal gradient. Six samples were performed at five different sites in Passa Cinco stream (from the headwater, at order two, to its mouth, at order six), using an electric fishery equipment and gill nets in May, July, September and November of 2005 and January and March of 2006. The indices of Shannon's diversity, Pielou's evenness and Margalef's richness were quantified separately considering the different fishery equipment (nets versus electric fishery equipment). An ANOVA was used to compare samples collected in relation to values of abundance, diversity, evenness and richness. The representativeness of the species was summarised by their average values of abundance and weight. We captured 5082 individuals distributed into 61 species. We observed a trend of increasing diversity, richness and evenness of species from site 1 to 3, with further decrease in sites 4 and 5. The values found for habitat diversity also followed this pattern. Significant differences were found for all three indices considering the electric fishery samples. For individuals caught with nets, only the richness index showed a significant difference. Characidium aff. zebra was an important species in the headwater and transition sites and Hypostomus strigaticeps in middle-lower course sites. Despite the small extension of the Passa Cinco stream, environments structurally well defined were evidenced by the species distribution and assemblage composition along the gradient. PMID:22437389

Carmassi, A L; Rondineli, G; Ferreira, F C; Braga, F M S

2012-02-01

5

Mineralogy, geochemistry and geological significance of tourmaline-rich rocks from the Paleozoic Cinco Villas massif (western Pyrenees, Spain)  

NASA Astrophysics Data System (ADS)

Tourmaline-rich rocks associated with clastic metasedimentary rocks of Carboniferous age occur in the Cinco Villas massif, western Pyrenees. Three types of tourmaline-rich rocks were distinguished: (1) Fine-grained stratiform tourmaline-rich rocks, which are associated with carbonaceous metapelites (TR1); (2) stratabound tourmaline-rich rocks, associated with metapelites in the contact aureole of the Aya granitoid pluton (TR2); (3) stratabound to massive tourmaline-rich rocks, associated with psammopelites in contact with granites and pegmatites (TR3). Tourmalines belong to the schorl-dravite solid solution series and have a wide compositional range, from nearly end-member dravite for TR1 tourmalines to schorl for TR3 tourmalines; TR2 tourmalines have intermediate compositions. The Fe/(Fe+Mg) typically varies between 0.02 and 0.55, increasing from TR1 to TR3. The TR1 tourmalines commonly display a discontinuous chemical zoning with Fe-rich green cores (8-8.5% FeO) and Mg-rich colorless rims (10-11% MgO). In contrast, crystals that exhibit fine growth lamellae appear to lack significant chemical zoning. Oxygen and hydrogen isotope compositions also reveal major differences between TR1 and TR3 tourmalines, the former displaying heavier ?18O values (17.7-19‰) and ?D values (-35 to -42‰) than TR3 tourmalines 11 to 13‰ and -47 to -76‰, respectively. The TR2 tourmalines show intermediate values of 11.3 to 14.6‰ for ?18O and -40 to -55‰ for ?D. Linear and continuous chemical variations obtained for major and trace elements of the whole rocks reflect mixing between clay-rich and quartz-rich end-members, indicative that some tourmaline-rich rocks contain a significant detrital component. Chondrite normalized REE (rare earth element) patterns of tourmaline-rich rocks are similar to those of surrounding unaltered clastic metasediments, except for some TR1 rocks which are characterized by low contents of ?REE. Mass-balance calculations show that tourmaline-forming processes plus metamorphism led to mass and volume changes at mesoscopic scales ( 10% for the TR1 tourmalinites). Silicon, Fe, Mn, and REE elements were partially lost from sedimentary rocks, whereas Mg and particularly B were added to pelitic sediments. Available data, nevertheless, do not allow an assessment of the boron source. Formation of the TR1 tourmaline-rich rocks probably was the net result of several processes, including direct precipitation from B-rich hydrothermal fluids or colloids, early diagenetic reactions of carbonaceous pelitic sediments with these fluids, and subsequent recrystallization during regional metamorphism. The TR2 tourmaline-rich rocks mainly developed by metamorphic recrystallization of TR1. Tourmaline-rich rocks and veins adjacent to pegmatites and granitic rocks (TR3) are the result of boron metasomatism; the primary boron having been recycled from stratiform tourmalinites during regional metamorphism and magmatism.

Pesquera, Alfonso; Velasco, Francisco

6

Los Cinco Grandes across cultures and ethnic groups: multitrait multimethod analyses of the Big Five in Spanish and English.  

PubMed

Spanish-language measures of the Big Five personality dimensions are needed for research on Hispanic minority populations. Three studies were conducted to evaluate a Spanish version of the Big Five Inventory (BFI) (O. P. John et al., 1991) and explore the generalizability of the Big Five factor structure in Latin cultural groups. In Study 1, a cross-cultural design was used to compare the Spanish and English BFI in college students from Spain and the United States, to assess factor congruence across languages, and to test convergence with indigenous Spanish Big Five markers. In Study 2, a bilingual design was used to compare the Spanish and English BFI in a college-educated sample of bilingual Hispanics and to test convergent and discriminant validity across the two languages as well as with the NEO Five Factor Inventory in both English and Spanish. Study 3 replicated the BFI findings from Study 2 in a working-class Hispanic bilingual sample. Results show that (a) the Spanish BFI may serve as an efficient, reliable, and factorially valid measure of the Big Five for research on Spanish-speaking individuals and (b) there is little evidence for substantial cultural differences in personality structure at the broad level of abstraction represented by the Big Five dimensions. PMID:9781409

Benet-Martínez, V; John, O P

1998-09-01

7

Factor XII (Hageman factor) deficiency  

MedlinePLUS

Factor XII deficiency is an inherited disorder that affects a protein (factor XII) involved in blood clotting. ... cascade. The process involves special proteins called coagulation factors. (Factor XII is a coagulation factor in this ...

8

El impacto de las reformas estructurales en la agricultura colombiana  

Microsoft Academic Search

Colombia, como la mayor parte de los países latinoamericanos, emprendió un ambicioso proceso de liberalización y reformas al clarear la década de los años noventa, el cual cobijó al sector agropecuario. Las reformas en el agro tuvieron tres períodos: desde el segundo semestre de 1990 hasta finales de 1992 se pusieron en marcha la mayoría de las reformas iniciales, de

Santiago Perry

2000-01-01

9

Factoring with the Factor Tree  

NSDL National Science Digital Library

This Java applet presents a composite number, and prompts you to factor it -- one step at a time. Enter one factor, prime or another composite; the applet calculates the remaining factor, and branches two boxes below any composite factor so that you may proceed factoring until you obtain the full factorization into primes, which the applet colors in green. Click the "Repeat problem" button to see that different factor trees for a given number still result in the same prime factorization.

Interactive Math Miscellany And Puzzles, Alexander B.

2011-01-01

10

Risk Factors  

MedlinePLUS

... on the characteristics we inherit from our parents. Environmental Risk Factors Many studies have been performed on a number of potential environmental risk factors. Of the many factors studied, only one— ...

11

Factor Findings  

NSDL National Science Digital Library

In this lesson, students first create factor posters for a variety of different numbers that will be displayed in the classroom to be utilized as a resource throughout the school year. They make discoveries about factors using color tiles, represent their discoveries using graph paper, and display their information on poster board as find factors of an assigned number. The plan includes a list of materials, questions, assessment options, and extensions.

Piecora, Jamie

2000-01-01

12

Risk Factors  

MedlinePLUS

... or not. The study, published in the Journal of the American Heart Association, found that depression and anxiety considerably raise ... factor for heart disease and stroke. Below is the percentage of U.S. adults with heart disease and stroke risk factors in 2005–2006. ...

13

Finding Factors  

NSDL National Science Digital Library

This lesson is designed to develop students' abilities to find factors of whole numbers. The lesson also introduces prime numbers. This lesson provides links to discussions and activities related to factors as well as suggested ways to integrate them into the lesson. Finally, the lesson provides links to follow-up lessons designed for use in succession with the current one.

2010-01-01

14

Prognostic factors.  

PubMed

The best predictive models of today can predict no more than 50% of the natural variability of the disease, despite the sophisticated mathematic analyses and the dozens of variables assessed. Clearly, a universe of still unknown prognostic factors remains to be discovered. Analogous to infinity being immeasurable, the fate of the individual patient will never be calculated mathematically. As the discovery of new prognostic factors continues, however, the prediction of the outcome of patients becomes more reliable. Although some prognostic factors (eg, tumor neoangiogenesis and quality of life) are already supported by a large body of evidence, recent research has introduced new groups of prognostic factors (eg, molecular genetic markers and the subclinical activation of coagulation fibrinolysis). Other intriguing factors (eg, a state of mental depression) might also be recognized as important in the near future. A new small portion of the universe has been explored. PMID:15005288

Buccheri, Gianfranco; Ferrigno, Domenico

2004-02-01

15

Power Factor  

NSDL National Science Digital Library

All About Circuits is a website that âÂÂprovides a series of online textbooks covering electricity and electronics.â Written by Tony R. Kuphaldt, the textbooks available here are wonderful resources for students, teachers, and anyone who is interested in learning more about electronics. This specific section, Power Factor, is the eleventh chapter in Volume II âÂÂAlternating Current. A few of the topics covered in this chapter include: True, Reactive, and Apparent power; Calculating power factor, and Practical power factor correction. Diagrams and detailed descriptions of concepts are included throughout the chapter to provide users with a comprehensive lesson. Visitors to the site are also encouraged to discuss concepts and topics using the All About Circuits discussion forums (registration with the site is required to post materials).

Kuphaldt, Tony R.

2008-07-10

16

Factor Lines  

NSDL National Science Digital Library

This flash applet provides students with an activity to become more familiar with factors and multiples. The challenge is to arrange the four number cards (1, 2, 3 and 21) on a square of the grid to make as many different diagonal, vertical or horizontal lines as possible. The number card can be placed on a square of the grid if the square is the same number, a multiple of that number and or a factor of that number. Users have the ability to change the difficulty level. The Teachers' Notes page offers rationale, suggestions for implementation, key discussion questions, ideas for extension and support.

2009-10-01

17

Testing Factorization.  

National Technical Information Service (NTIS)

We briefly review the status of factorization in b-decays. We discuss several experimental tests of its nature and stress their importance. We show that decays into mesons which have small decay constants or spin greater than one ('designer mesons') offer...

G. Hiller

2001-01-01

18

Factor XII assay  

MedlinePLUS

Hageman factor assay ... one of your blood relatives was diagnosed with factor XII deficiency. ... Decreased factor XII activity may indicate: Inherited (congenital) deficiency of factor XII Liver disease

19

Antihemophilic Factor/von Willebrand Factor Complex  

Center for Biologics Evaluation and Research (CBER)

... About the Center for Biologics Evaluation and Research. -. Antihemophilic Factor/von Willebrand Factor Complex. -. Products. ... More results from www.fda.gov/biologicsbloodvaccines/bloodbloodproducts/approvedproducts

20

Affective Factors in Reading.  

ERIC Educational Resources Information Center

A discussion of the role of affective factors in reading within the framework of the substrata factor theory is presented. The substrata factor theory and theories of the intellect are briefly discussed, and the absence of affective factors in these theories is pointed out. These affective factors are seen as influential in the individual's…

Athey, Irene

21

Factoring Multivariate Integral Polynominals.  

National Technical Information Service (NTIS)

A polynomial-time algorithm to factor polynomials in several variables with integral coefficients that is polynomial-time in the degrees of the polynomial to be factored is presented. This algorithm generalizes the algorithm to factor integral polynomials...

A. K. Lenstra

1983-01-01

22

6.NS Factors and Common Factors  

NSDL National Science Digital Library

This is a task from the Illustrative Mathematics website that is one part of a complete illustration of the standard to which it is aligned. Each task has at least one solution and some commentary that addresses important asects of the task and its potential use. Here are the first few lines of the commentary for this task: List all the factors of 48. List all the factors of 64. What are the common factors of 48 and 64? What is the greatest common factor of 48 and 64?...

23

DISEÑO AUTOMATIZADO, MEDIANTE TÉCNICAS DE SISTEMAS EXPERTOS EN CATIA V5, APLICADO A COMPONENTES ESTRUCTURALES AERONÁUTICOS  

Microsoft Academic Search

In a plane typical structure, many elements are geometrically identical: wings, vertical tail plane, flaps, ailerons, etc, adapting the supporter profile form, so studied in the aerodynamics. It is from this perception that the idea of automating its design emerges. This work, resulting from the collaboration with the CAD-CAM department in EADS-CASA, aims to go a step further, taking advantage

MARTINEZ PALACIOS; MARTINEZ LOMAS; María Eugenia; LÓPEZ CARRERAS; DEL RIO CIDONCHA; María Gloria

24

Fallas estructurales del mercado de maíz. Comentario a Robles y García  

Microsoft Academic Search

El artículo es un esfuerzo valioso por parte de economistas para poner (por fin) a funcionar el instrumental de la teoría económica sobre un tema del que sólo parecen ocuparse antropólogos y agrónomos. La carencia de investigación empírica y de reflexión analítica sobre aspectos centrales de la realidad económica del país habla mal del estado que guarda la disciplina de

Ángel Palerm

1995-01-01

25

Evaluación de los efectos de los fondos estructurales en la economía andaluza  

Microsoft Academic Search

The objective of this paper is, basically, to evaluate the effects that the Community Support Framework has on relevant indicators of the Andalusian economy such as growth, added value, employment, etc., through simulations with the input-output tables of Andalusia. Furthermore, it is considered to verify if investment, that theoretically should generate a positive compensatory effect on the objective region and

Antonio Morillas; Laura Moniche; J. Marcos Castro

1999-01-01

26

Activation of human factor IX (Christmas factor).  

PubMed

Human Factor IX (Christmas factor) is a single-chain plasma glycoprotein (mol wt 57,000) that participates in the middle phase of the intrinsic pathway of blood coagulation. It is present in plasma as a zymogen and is converted to a serine protease, Factor IXabeta, by Factor XIa (activated plasma thromboplastin antecedent) in the presence of calcium ions. In the activation reaction, two internal peptide bonds are hydrolyzed in Factor IX. These cleavages occur at a specific arginyl-alanine peptide bond and a specific arginyl-valine peptide bond. This results in the release of an activation peptide (mol wt approximately equal to 11,000) from the internal region of the precursor molecule and the generation of Factor IXabeta (mol wt approximately equal to 46,000). Factor IXabeta is composed of a light chain (mol wt approximately equal to 18,000) and a heavy chain (mol wt approximately equal to 28,000), and these chains are held together by a disulfide bond(s). The light chain originates from the amino terminal portion of the precursor molecule and has an amino terminal sequence of Tyr-Asn-Ser-Gly-Lys. The heavy chain originates from the carboxyl terminal region of the precursor molecule and contains an amino terminal sequence of Val-Val-Gly-Gly-Glu. The heavy chain of Factor IXabeta also contains the active site sequence of Phe-Cys-Ala-Gly-Phe-His-Glu-Gly-Arg-Asp-Ser-Cys-Gln-Gly-Asp-SER-Gly-Gly-Pro. The active site serine residue is shown in capital letters. Factor IX is also converted to Factor IXaalpha by a protease from Russell's viper venom. This activation reaction, however, occurs in a single step and involves only the cleavage of the internal arginyl-valine peptide bond. Human Factor IXabeta was inhibited by human antithrombin III by the formation of a one-to-one complex of enzyme and inhibitor. In this reaction, the inhibitor was tightly bound to the heavy chain of the enzyme. These data indicate that the mechanism of activation of human Factor IX and its inhibition by antithrombin III is essentially identical to that previously shown for bovine Factor IX. PMID:659613

Di Scipio, R G; Kurachi, K; Davie, E W

1978-06-01

27

Activation of human factor IX (Christmas factor).  

PubMed Central

Human Factor IX (Christmas factor) is a single-chain plasma glycoprotein (mol wt 57,000) that participates in the middle phase of the intrinsic pathway of blood coagulation. It is present in plasma as a zymogen and is converted to a serine protease, Factor IXabeta, by Factor XIa (activated plasma thromboplastin antecedent) in the presence of calcium ions. In the activation reaction, two internal peptide bonds are hydrolyzed in Factor IX. These cleavages occur at a specific arginyl-alanine peptide bond and a specific arginyl-valine peptide bond. This results in the release of an activation peptide (mol wt approximately equal to 11,000) from the internal region of the precursor molecule and the generation of Factor IXabeta (mol wt approximately equal to 46,000). Factor IXabeta is composed of a light chain (mol wt approximately equal to 18,000) and a heavy chain (mol wt approximately equal to 28,000), and these chains are held together by a disulfide bond(s). The light chain originates from the amino terminal portion of the precursor molecule and has an amino terminal sequence of Tyr-Asn-Ser-Gly-Lys. The heavy chain originates from the carboxyl terminal region of the precursor molecule and contains an amino terminal sequence of Val-Val-Gly-Gly-Glu. The heavy chain of Factor IXabeta also contains the active site sequence of Phe-Cys-Ala-Gly-Phe-His-Glu-Gly-Arg-Asp-Ser-Cys-Gln-Gly-Asp-SER-Gly-Gly-Pro. The active site serine residue is shown in capital letters. Factor IX is also converted to Factor IXaalpha by a protease from Russell's viper venom. This activation reaction, however, occurs in a single step and involves only the cleavage of the internal arginyl-valine peptide bond. Human Factor IXabeta was inhibited by human antithrombin III by the formation of a one-to-one complex of enzyme and inhibitor. In this reaction, the inhibitor was tightly bound to the heavy chain of the enzyme. These data indicate that the mechanism of activation of human Factor IX and its inhibition by antithrombin III is essentially identical to that previously shown for bovine Factor IX. Images

Di Scipio, R G; Kurachi, K; Davie, E W

1978-01-01

28

Antihemophilic Factor (Human)  

MedlinePLUS

Your doctor has ordered antihemophilic factor (human), an antihemophilic factor, to help your blood to clot. The drug will be either injected directly into your vein or added to an intravenous fluid ...

29

Factors Influencing Army Accessions.  

National Technical Information Service (NTIS)

The subject of this thesis is accessions and the factors influencing a potential recruit's decision to join the Army. Six types of analysis were performed: regression analysis, data base profile analysis through SPSS Frequencies and Crosstabs, factor anal...

K. M. Kalinich D. C. Wenzel

1982-01-01

30

Factoring Polynomials and Fibonacci.  

ERIC Educational Resources Information Center

|Discusses the factoring of polynomials and Fibonacci numbers, offering several challenges teachers can give students. For example, they can give students a polynomial containing large numbers and challenge them to factor it. (JN)|

Schwartzman, Steven

1986-01-01

31

Factors, Arrays and Commutativity  

NSDL National Science Digital Library

Students look at different arrangements of desks, discuss the number of factor pairs and relate this to the commutative property of multiplication. They learn why they must try factors up to the square root of a number.

Wnet

2008-08-22

32

Factor VII assay  

MedlinePLUS

When you bleed, the body launches a series of activities that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors (factor VII is a ...

33

Factor X assay  

MedlinePLUS

When you bleed, the body launches a series of activities that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors (factor X is a ...

34

Factor II assay  

MedlinePLUS

When you bleed, the body launches a series of activities that help the blood clot. This is called the coagulation cascade. The process involves special proteins called coagulation factors (factor II is a ...

35

Factoring Polynomials Modulo Composites.  

National Technical Information Service (NTIS)

This paper characterizes all the factorizations of a polynomial with coefficients in the ring Zn where n is a composite number. We give algorithms to compute much factorizations along with algebraic classifications.

A. Klivans

1997-01-01

36

Factor V deficiency  

MedlinePLUS

... cause is unknown. The disease is similar to hemophilia , except bleeding into joints is less common. In the inherited form of Factor V deficiency, a family history of a bleeding disorder is a risk factor.

37

The Venn Factor  

NSDL National Science Digital Library

This lesson plan provides the teacher with an activity to help students calculate the Greatest Common Factor of two or more positive integers and develop a definition based on their exploration. Students find the prime factorization of two positive numbers using factor trees and Venn diagrams to sort the prime factors. The plan includes learning objectives, materials needed, questions to ask students, assessment options, extensions, teacher self-reflection questions, and further references.

Barron, Hilary R.

2010-01-01

38

Multiple factor analysis  

Microsoft Academic Search

The purpose of the paper is to describe a more generally applicable method of factor analysis which has no restrictions as regards group factors and which does not restrict the number of general factors that are operative in producing the intercorrelation. Applications of the method to different types of correlation problems are suggested.

L. L. Thurstone

1931-01-01

39

Human factors in mining  

SciTech Connect

This Bureau of Mines report is directed toward summarizing the application of human factors to improving safety, productivity, and the general physical and psychological working conditions of miners and toward familiarizing readers with the role of human factors in the mining industry and the benefits that car accrue by systematically applying human factors principles and data.

Sanders, M.S.; Peay, J.M.

1988-01-01

40

Multilevel Mixture Factor Models  

ERIC Educational Resources Information Center

|Factor analysis is a statistical method for describing the associations among sets of observed variables in terms of a small number of underlying continuous latent variables. Various authors have proposed multilevel extensions of the factor model for the analysis of data sets with a hierarchical structure. These Multilevel Factor Models (MFMs)…

Varriale, Roberta; Vermunt, Jeroen K.

2012-01-01

41

The Factorization Problem - A Survey.  

National Technical Information Service (NTIS)

The problem of factoring a positive Hermitian operator into the product of a causal operator and its adjoint is reviewed. Three classes of factorization are studied, miniphase factorization, regular factorization, and special factorization. The former alw...

R. Saeks

1975-01-01

42

Integer Factorization Methods  

Microsoft Academic Search

In the past, factoring integers was thought to be of little benefit to the mathematical world. The subject of integer factorization methods is one that has only relatively recently become of interest to mathematicians, as cryptography and other fields have made its thorough study a necessity.\\u000aHere, we study the continued fraction method of factorization, which is an early method

Stephanie Faith Vergara

2011-01-01

43

Oversimplifying quantum factoring.  

PubMed

Shor's quantum factoring algorithm exponentially outperforms known classical methods. Previous experimental implementations have used simplifications dependent on knowing the factors in advance. However, as we show here, all composite numbers admit simplification of the algorithm to a circuit equivalent to flipping coins. The difficulty of a particular experiment therefore depends on the level of simplification chosen, not the size of the number factored. Valid implementations should not make use of the answer sought. PMID:23846653

Smolin, John A; Smith, Graeme; Vargo, Alexander

2013-07-11

44

Activating transcription factor 4  

Microsoft Academic Search

Activating transcription factor 4 (ATF4) belongs to the ATF\\/CREB (activating transcription factor\\/cyclic AMP response element binding protein) family of basic region-leucine zipper (bZip) transcription factors, which have the consensus binding site cAMP responsive element (CRE). ATF4 has numerous dimerization partners. ATF4 is induced by stress signals including anoxia\\/hypoxia, endoplasmic reticulum stress, amino acid deprivation, and oxidative stress. ATF4 expression is

Kurosh Ameri; Adrian L. Harris

2008-01-01

45

Factoring with an Oracle  

Microsoft Academic Search

The problem of factoring integers in polynomial time with the help of an (infinitely powerful) oracle who answers arbitrary\\u000a questions with yes or no is considered. The goal is to minimize the number of oracle questions. Let N be a given composite n-bit integer to be factored. The trivial method of asking for the bits of the smallest prime factor

Ueli M. Maurer

1992-01-01

46

Avaliação da qualidade operacional em cinco subsistemas de colheita florestal  

Microsoft Academic Search

Operational quality was assessed in five harvesting subsystems adopted by Brazilian forest companies that use wood for cellulose and fiber sheets. The short log system is used by the companies and the subsystems are 1) Harvest + Forwarder; 2) Slingshot + Forwarder; 3) Chainsaw + Manual; 4) Chainsaw + Forwarder and 5) Chainsaw and tow. Stump height and fracture range,

Laércio Antônio Gonçalves Jacovine; Carlos Cardoso Machado; Amaury Paulo de Souza; Helio Garcia Leite; Luciano José Minetti

2005-01-01

47

Antihemophilic Factor (Human), Alphanate  

Center for Biologics Evaluation and Research (CBER)

... Research (CBER) has identified promotional material for your product, Alphanate (Antihemophilic Factor (Human)), that violates ... signature -----. ... More results from www.fda.gov/biologicsbloodvaccines/guidancecomplianceregulatoryinformation/complianceactivities

48

Meningococcal Disease: Risk Factors  

MedlinePLUS

... Contact CDC-INFO Meningococcal Disease Home About the Disease Risk Factors Age Community Settings Certain Medical Conditions Travel Causes & Transmission Signs & Symptoms Diagnosis & Treatment Prevention ...

49

Factorized Weight Functions vs. Factorized Scattering  

NASA Astrophysics Data System (ADS)

Starting from an extensive class of factorized weight functions W(p) on the N-dimensional torus ?, we construct an orthonormal base of symmetric N-variable polynomials for L2s(?,W(p)dp) via lexicographic ordering of the monomial symmetric functions (free boson states) and the Gram-Schmidt procedure. We show that the dominant asymptotics of these polynomials is factorized. As a corollary, we obtain a large class of quantum integrable soliton systems on the symmetric subspace of l2(N). The class of weight functions contains in particular the weight function yielding Macdonald polynomials. For that special case, the quantum soliton system can be viewed as the dual relativistic Calogero-Sutherland system.

Ruijsenaars, S. N. M.

50

Independent Factor Analysis  

Microsoft Academic Search

We introduce the independent factor analysis (IFA) method for recovering independent hidden sourcesfrom their observed mixtures. IFA generalizes and unifies ordinary factor analysis (FA), principal componentanalysis (PCA), and independent component analysis (ICA), and can handle not only squarenoiseless mixing, but also the general case where the number of mixtures differs from the number ofsources and the data are noisy. IFA

Hagai Attias; W. M. Keck

1999-01-01

51

Risk factors for tuberculosis  

Microsoft Academic Search

Risk factors for tuberculosis. P.D.O. Davies. The risk of developing tuberculosis is dependent on both the risk of being infected and the risk of infection lead- ing on to active disease. The former will depend on the inci- dence of tuberculosis in the community where the individual lives or works. The latter will depend on many factors im- pinging on

P. D. O. Davies

2005-01-01

52

Integer Factorization Using Hadoop  

Microsoft Academic Search

Integer factorization is an interesting but a hard problem and stays at the core of many security mechanisms. Conventional approaches to factor big integer numbers often require powerful computers and a great effort in software development. In this paper, we present a different approach to this problem by running the quadratic sieve algorithm in the Hadoop framework. This approach offers

Son T. Nguyen; Semere Tsehaye Ghebregiorgish; Nour Alabbasi; Chunming Rong

2011-01-01

53

Form factor dark matter  

Microsoft Academic Search

We present a dynamical alternative to inelastic dark matter as a way of reconciling the modulating signal seen at DAMA with null results at other direct detection experiments. The essential ingredient is a new form factor which introduces momentum dependence in the interaction of dark matter with nuclei. The role of the form factor is to suppress events at low

Brian Feldstein; A. Liam Fitzpatrick; Emanuel Katz

2010-01-01

54

Factors affecting tanker safety  

Microsoft Academic Search

The major factors influencing tanker safety are discussed. For the discussion information has been gleaned from maritime labour officials, industry experts and a recent United States Coast Guard study on tanker safety. Results of other tanker safety studies and\\/or accident reports are also utilized. Some of the factors analysed are the size and age of vessel, licence qualifications for mates

Craig J. Forsyth

1991-01-01

55

FACTORS IN COLLEGE ATTENDANCE  

Microsoft Academic Search

PURPOSE OF THIS RESEARCH WAS TO IDENTIFY FACTORS, OBTAINED FROM A SELF-REPORT INVENTORY, DETERMINING THE DECISION TO ATTEND COLLEGE. 214 MALE AND 306 FEMALE STUDENTS FROM THE STATE UNIVERSITY COMPLETED A 78-ITEM INVENTORY, REASONS FOR GOING TO COLLEGE, AS FRESHMEN AND AGAIN AS SENIORS. ANALYSES AND MATCHING PROCEDURES YIELDED 13 MAJOR FACTORS: SOCIAL REASON, CONFORMITY, CURIOSITY, VOCATIONAL REASON, ACADEMIC VALUE,

ARTHUR A. DOLE; JOHN M. DIGMAN

1967-01-01

56

Fibroblast growth factors  

Microsoft Academic Search

SUMMARY: Fibroblast growth factors (FGFs) make up a large family of polypeptide growth factors that are found in organisms ranging from nematodes to humans. In vertebrates, the 22 members of the FGF family range in molecular mass from 17 to 34 kDa and share 13-71% amino acid identity. Between vertebrate species, FGFs are highly conserved in both gene structure and

David M Ornitz; Nobuyuki Itoh

2001-01-01

57

EXPOSURE FACTORS PROGRAM  

EPA Science Inventory

The development of the latest version of the Exposure Factors Handbook (EFH): 2011 Edition (EPA/600/R-09/052F) has maintained the need for a more comprehensive program that addresses issues related to exposure factors. Since the first version of the EFH was r...

58

Resilience factors in PTSD  

Microsoft Academic Search

Only a relatively small percentage of the people exposed to traumatic events develop PTSD. While much research has focused on the etiology of the disorder and on risk factors, possible resilience factors in post-traumatic adjustment have been studied considerably less extensively. The field of psychology provides several constructs and theoretical paradigms that may aid in the understanding of resilience. Hardiness,

A. R. Rademaker; R. J. Kleber; J. Houtenbrink; J. Hakkesteegt; E. Vermetten

2006-01-01

59

Vitiligo – Exogenous Factors  

Microsoft Academic Search

Vitiligo is an acquired depigmentary disorder of the skin that results from the selective destruction of melanocytes. The etiology of vitiligo is poorly understood. There appears to be a genetic predisposition, but additional factors are probably involved. The purpose of this article is to outline the factors that might play a role in the development of vitiligo. These include trauma

Hagit Matz; Ethel Tur

2004-01-01

60

Nucleotide exchange factors  

PubMed Central

Exchange factors are enzymes that catalyze the exchange of GTP for GDP on guanine nucleotide binding proteins. Progress in understanding the molecular basis of action and the cellular functions of these enzymes has largely come from structural determinations (e.g., crystal structures) and studying effects on cells when expression levels of the exchange factors are perturbed or mutated exchange factors are expressed. Proportionally little effort has been expended on studying the kinetics of exchange; however, reaction rates are central to understanding enzymes. Here, we discuss the importance of kinetic analysis of exchange factors for guanine nucleotide binding proteins, with a focus on ADP-ribosylation factor (Arf) and heterotrimeric G proteins, for providing unique insights into molecular mechanisms and regulation as well as how kinetic analyses are used to complement other approaches.

Northup, John K.; Jian, Xiaoying; Randazzo, Paul A.

2012-01-01

61

Risk Factors for Tuberculosis  

PubMed Central

The risk of progression from exposure to the tuberculosis bacilli to the development of active disease is a two-stage process governed by both exogenous and endogenous risk factors. Exogenous factors play a key role in accentuating the progression from exposure to infection among which the bacillary load in the sputum and the proximity of an individual to an infectious TB case are key factors. Similarly endogenous factors lead in progression from infection to active TB disease. Along with well-established risk factors (such as human immunodeficiency virus (HIV), malnutrition, and young age), emerging variables such as diabetes, indoor air pollution, alcohol, use of immunosuppressive drugs, and tobacco smoke play a significant role at both the individual and population level. Socioeconomic and behavioral factors are also shown to increase the susceptibility to infection. Specific groups such as health care workers and indigenous population are also at an increased risk of TB infection and disease. This paper summarizes these factors along with health system issues such as the effects of delay in diagnosis of TB in the transmission of the bacilli.

Narasimhan, Padmanesan; Wood, James; MacIntyre, Chandini Raina; Mathai, Dilip

2013-01-01

62

Purification and characterization of an abnormal factor IX (Christmas factor) molecule. Factor IX Chapel Hill.  

PubMed Central

Human Factor IX (Christmas factor) was isolated from the plasma of a patient with mild hemophilia B. The patient's plasma contained 5% Factor IX clotting activity but 100% Factor IX antigenic activity as determined by immunological assays, which included inhibitor neutralization and a radioimmunoassay for Factor IX. This abnormal Factor IX is called Factor IX Chapel Hill (Factor IXCH). Both normal Factor IX and Factor IXCH have tyrosine as the NH2-terminal amino acid. The two proteins have a similar molecular weight, a similar amino acid analysis, the same number of gamma-carboxyglutamic acid residues (10 gamma-carboxyglutamic acid residues), and a similar carbohydrate content. Both exist as a single-chain glycoprotein in plasma. The major difference between normal Factor IX and Factor IXCH is that the latter exhibits delayed activation to Factor IXa in the presence of Factor XIa and Ca2+. Thus, Factor IXCH differs from other previously described abnormal Factor IX molecules. Images

Chung, K S; Madar, D A; Goldsmith, J C; Kingdon, H S; Roberts, H R

1978-01-01

63

Scaling factors: Transcription factors regulating subcellular domains  

PubMed Central

Developing cells acquire mature fates in part by selective (i.e. qualitatively different) expression of a few cell-specific genes. However, all cells share the same basic repertoire of molecular and sub-cellular building blocks. Therefore, cells must also specialize according to quantitative differences in cell-specific distributions of those common molecular resources. Here we propose the novel hypothesis that evolutionarily-conserved transcription factors called scaling factors (SFs) regulate quantitative differences among mature cell types. SFs: 1) are induced during late stages of cell maturation; 2) are dedicated to specific sub-cellular domains; and, thus, 3) allow cells to emphasize specific sub-cellular features. We identify candidate SFs and discuss one in detail: MIST1 (BHLHA15, vertebrates)/ DIMM (CG8667, Drosophila); professional secretory cells use this SF to scale up regulated secretion. Because cells use SFs to develop their mature properties and also to adapt them to ever-changing environmental conditions, SF aberrations likely contribute to diseases of adult onset.

Mills, Jason C.; Taghert, Paul H.

2012-01-01

64

Assessment of Human Factors.  

National Technical Information Service (NTIS)

Human Factors Engineering, often referred to as Ergonomics, is a science that applies a detailed understanding of human characteristics, capabilities, and limitations to the design, evaluation, and operation of environments, tools, and systems for work an...

F. Mount T. Foley

1999-01-01

65

Specialized Integer Factorization  

Microsoft Academic Search

Vanstone and Zuccherato [3] propose a cryptographic system based on an elliptic curve modulo a composite number. We show that\\u000a the composite numbers so constructed are easily factored, rendering the system insecure.

Don Coppersmith

1998-01-01

66

Neutron quality factor.  

National Technical Information Service (NTIS)

Both the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) have recommended that the radiation quality weighting factor for neutrons (Q(sub n), or the corresponding new modi...

1995-01-01

67

Factors Affecting Wound Healing  

PubMed Central

Wound healing, as a normal biological process in the human body, is achieved through four precisely and highly programmed phases: hemostasis, inflammation, proliferation, and remodeling. For a wound to heal successfully, all four phases must occur in the proper sequence and time frame. Many factors can interfere with one or more phases of this process, thus causing improper or impaired wound healing. This article reviews the recent literature on the most significant factors that affect cutaneous wound healing and the potential cellular and/or molecular mechanisms involved. The factors discussed include oxygenation, infection, age and sex hormones, stress, diabetes, obesity, medications, alcoholism, smoking, and nutrition. A better understanding of the influence of these factors on repair may lead to therapeutics that improve wound healing and resolve impaired wounds.

Guo, S.; DiPietro, L.A.

2010-01-01

68

Probabilities: The Astronomical Factors  

Microsoft Academic Search

\\u000a Guthke may have been too dismissive when he wrote that the Drake equation is made up entirely of unknowns.1 Since that equation was written, there have been significant scientific findings affecting some of its factors.

Michael A. G. Michaud

69

Managing Multiple Risk Factors.  

National Technical Information Service (NTIS)

Current research provides evidence that a higher prevalence of obesity, a more centralized fat pattern and a clustering of cardiovascular risk factors (i.e., overweight/obesity, hypertension, hyperinsulinemia, insulin resistance, dyslipidemia, neurohumora...

C. M. Lollis

1998-01-01

70

von Willebrand Factor  

MedlinePLUS

... to be due (or actually be due) to hemophilia A, a factor VIII deficiency bleeding disorder that ... Know About von Willebrand Disease? World Federation of Hemophilia: What is von Willebrand disease (VWD)? Canadian Hemophilia ...

71

Human Factors in Diving.  

National Technical Information Service (NTIS)

Dive safety is primarily a function of four factors: the environment, equipment, individual diver performance and dive team performance. The water is a harsh and alien environment which can impose severe physical and psychological stress on a diver. The r...

M. A. Blumenberg

1996-01-01

72

Angiogenic Factors and Preeclampsia  

PubMed Central

Summary Preeclampsia, a hypertensive disorder peculiar to pregnancy, is a systemic syndrome that appears to originate in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of phenotypic preeclampsia was largely unknown, but recent observations support the hypothesis that altered expression of placental anti-angiogenic factors are responsible for the clinical manifestation of the disease. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal circulation weeks before the onset of preeclampsia. These anti-angiogenic factors produce systemic endothelial dysfunction, resulting in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, and as of 2010 the role of angiogenic proteins in early placental vascular development was starting to be explored. The data linking angiogenic factors to preeclampsia have exciting clinical implications, and likely will transform the detection and treatment of preeclampsia.

Maynard, Sharon E.; Karumanchi, S. Ananth

2011-01-01

73

Limiting Factors in Ecosystems  

NSDL National Science Digital Library

This unit, designed to span two class periods, helps students understand that physical factors, particularly temperature and precipitation, limit the growth of plant ecosystems. The activity begins with a discussion in which students develop their own ideas about the role of temperature, precipitation, and environment on plant growth. They will then examine X-Y graphs of vegetation growth, temperature, and precipitation versus month for four diverse ecosystems to determine which climatic factor is limiting growth. A worksheet and scoring rubric are provided.

74

FGF growth factor analogs  

SciTech Connect

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2012-07-24

75

Interest rates factor model  

NASA Astrophysics Data System (ADS)

Interdependence of the interest rates of the US, the UK, and Japan is analyzed in this work by means of spectral analysis and network methods. A predominant effective factor in the interest rate market is which country floats a bond issue, and a minor effective factor is time to maturity of bonds. Power-law cross-correlation among different countries is analyzed by the detrended cross-correlation analysis method. Long-range cross-correlation is found between the first factors of interest rate, while there is no cross-correlation between some of the second factors. The tail dependency is indicated by tail indices from Archimedean copulas, including an empirical copula. In contrast to other pairs, the US–UK first factor pair has tail dependencies in both the upper-tail and lower-tail. Dynamic properties of interest rate are modeled by a stochastic volatility model. The properties of mean reverting and volatility clustering are observed and reflected in this model. The proposed simulation method combines the dependence structures and the factor dynamics model; it simultaneously describes the interest rates of different countries.

Lee, Sangwook; Kim, Min Jae; Kim, Soo Yong

2011-07-01

76

Relativistic Variable Eddington Factor  

NASA Astrophysics Data System (ADS)

We analytically derived a relativistic variable Eddington factor in relativistic radiative flow, and found that the Eddington factor depends on the velocity gradient as well as the flow velocity. When the gaseous flow is accelerated and there is a velocity gradient, there also exists a density gradient. As a result, an unobstructed viewing range by a comoving observer, where the optical depth measured from the comoving observer is unity, is not a sphere, but becomes an oval shape elongated in the direction of the flow; we call it a one-tau photo-oval. For a comoving observer, an inner wall of the photo-oval generally emits at a non-uniform intensity, and has a relative velocity. Thus, the comoving radiation fields observed by the comoving observer becomes anisotropic, and the Eddington factor must deviate from the value for the isotropic radiation fields. In the case of a plane-parallel vertical flow, we examine the photo-oval and obtain the Eddington factor. In a sufficiently optically thick linear regime, the Eddington factor is analytically expressed as f(?,?,{d?}/{d?} = 1/3 (1 + {16/15} {d?}/{d?}), where ? is the optical depth and ? (= v/c) is the flow speed normalized by the speed of light. We also examined the linear and semi-linear regimes, and found that the Eddington factor generally depends both on the velocity and its gradient.

Fukue, Jun

2008-04-01

77

FACTOR: AN INTEGER FACTORIZATION PROGRAM FOR THE IBM PC  

Microsoft Academic Search

Factor is a program which accesses a large database of factors of integers of the form an ± 1. As of October 1989 the database contains more than 30,000 factors of size at least 104. The program Factor implements a simple version of the Elliptic Curve algorithm if it is unable to complete a factorization using trial division and the

RICHARD P. BRENT

78

New thrombopoietic growth factors  

PubMed Central

Although development of first-generation thrombopoietic growth factors (recombinant human thrombopoietin [TPO] and pegylated recombinant human megakaryocyte growth and development factor [PEG-rHuMGDF]) was stopped due to development of antibodies to PEG-rHuMGDF, nonimmunogenic second-generation thrombopoietic growth factors with unique pharmacologic properties have been developed. TPO peptide mimetics contain TPO receptor-activating peptides inserted into complementarity-determining regions of Fab (Fab 59), attached to the IgG Fc region (AMG 531), or pegylated (Peg-TPOmp). Orally available, TPO nonpeptide mimetics (eltrombopag, AKR-501) bind and activate the TPO receptor by a mechanism different from TPO and may have an additive effect to TPO. TPO agonist antibodies are monoclonal antibodies activating the TPO receptor but modified in size [TPO minibodies; ie, VB22B sc(Fv)2] or immunoglobuln type (domain subclass-converted TPO agonist antibodies; ie, MA01G4G344). All second-generation thrombopoietic growth factors stimulate growth of TPO-dependent cell lines via JAK2/STAT signaling pathways and increase platelet counts in animals. When tested in healthy humans, TPO peptide and nonpeptide mimetics produced a dose-dependent rise in platelet count. AMG 531 and eltrombopag markedly increase platelet counts in patients with immune thrombocytopenic purpura, without significant adverse effects. One or more second-generation thrombopoietic growth factors should soon be clinically available for treating thrombocytopenic disorders.

2007-01-01

79

Peptide growth factors, part A  

SciTech Connect

This book contains information on the following topics: Epidermal Growth Factor;Transforming Growth Factors;Bone and Cartilage Growth Factors;Somatomedin/Insulin-Like Growth Factors;Techniques for the Study of Growth Factor Activity;Assays, Phosphorylation, and Surface Membrane Effects.

Barnes, D.; Sirbasku, D.A.

1987-01-01

80

FACTOR WIDTHS OF NONNEGATIVE MATRICES  

Microsoft Academic Search

Factor widths of nonnegative integral positive semideflnite square matrices are investigated. The nonnegative factor width, the exact factor width and the binary factor width of such matrices are introduced. Some lower and upper bounds for these widths are obtained. Nonnegative symmetric (com- pletely positive) matrices with some given nonnegative (binary) factor widths are also explored.

CHANGQING XU; GUANGHUI XU

81

Psychological Factors in Asthma  

PubMed Central

Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and symptom reporting. Emerging evidence suggests that the relation between asthma and psychological factors may be more complex than that, however. Central cognitive processes may influence not only the interpretation of asthma symptoms but also the manifestation of measurable changes in immune and physiologic markers of asthma. Furthermore, asthma and major depressive disorder share several risk factors and have similar patterns of dysregulation in key biologic systems, including the neuroendocrine stress response, cytokines, and neuropeptides. Despite the evidence that depression is common in people with asthma and exerts a negative impact on outcome, few treatment studies have examined whether improving symptoms of depression do, in fact, result in better control of asthma symptoms or improved quality of life in patients with asthma.

2008-01-01

82

Antiretroviral Restriction Factors  

PubMed Central

Studies of retroviruses have been instrumental in revealing the existence of an array of antiviral proteins, or restriction factors, and the mechanisms by which they function. Some restriction factors appear to specifically inhibit retrovirus replication, while others have a broader antiviral action. Here, we briefly review current understanding of the mechanisms by which several such proteins exert antiviral activity. We also discuss how retroviruses have evolved to evade or antagonize antiviral proteins, including through the action of viral accessory proteins. Restriction factors, their viral targets and antagonists have exerted evolutionary pressure on each other, resulting in specialization and barriers to cross-species transmission. Potentially, this recently revealed intrinsic system of antiviral immunity might be mobilized for therapeutic benefit.

Hatziioannou, Theodora; Bieniasz, Paul D.

2011-01-01

83

?????(?,?') transition form factors  

NASA Astrophysics Data System (ADS)

The surprising results by the BABAR Collaboration on the ?? transition form factor require new thoughts about the high-Q2 dependence of the form factors with virtual photons. We make use of the anomaly sum rule [J. Horejsi and O. Teryaev, Z. Phys. C 65, 691 (1995).ZPCFD20170-973910.1007/BF01578676] which relates the hadron spectral density to the axial anomaly [S. Adler, Phys. Rev. 177, 2426 (1969); J. S. Bell and R. Jackiw, Nuovo Cimento A 60, 47 (1969).]. We study the quark-hadron duality relation for this sum rule and find out that the increase of the rescaled form factor Q2F??(Q2)˜log?(Q2) suggested by the BABAR data requires the presence of a 1/s-correction term in the relation between the one-loop spectral density and the hadron-continuum spectral density.

Melikhov, Dmitri; Stech, Berthold

2012-03-01

84

Classical Atomic Form Factor  

NASA Astrophysics Data System (ADS)

The general trends exhibited in the variation of the inelastic form factor in collisional transitions nl-->n'l', when l' is changed and n, l, and n' are kept fixed, are explained solely in terms of classical mechanics. Previous quantal results are reproduced from purely classical mechanics principles. Our conclusions are valid not only for large quantum numbers (which provide the usual classical correspondence) but also for other cases, which, up to now have been described only by quantal or semiclassical methods. The interesting trends exhibited in the form factor are directly reflected in experimental and theoretical treatments of collisions involving excited atoms.

Vrinceanu, D.; Flannery, M. R.

1999-04-01

85

All electromagnetic form factors  

NASA Astrophysics Data System (ADS)

The electromagnetic form factors of spin-1/2 particles are known, but due to historical reasons only half of them are found in many textbooks. Given the importance of the general result, its model independence, its connection to discrete symmetries and their violations we made an effort to derive and present the general result based only on the knowledge of the Dirac equation. We discuss the phenomenology connected directly with the form factors, and spin precession in external fields including time-reversal violating terms. We apply the formalism to spin-flip synchrotron radiation and suggest pedagogical projects.

Nowakowski, M.; Paschos, E. A.; Rodríguez, J. M.

2005-07-01

86

Factorizations and physical representations  

NASA Astrophysics Data System (ADS)

A Hilbert space in M dimensions is shown explicitly to accommodate representations that reflect the decomposition of M into prime numbers. Representations that exhibit the factorization of M into two relatively prime numbers: the kq representation (Zak J 1970 Phys. Today 23 51), and related representations termed q1q2 representations (together with their conjugates) are analysed, as well as a representation that exhibits the complete factorization of M. In this latter representation each quantum number varies in a subspace that is associated with one of the prime numbers that make up M.

Revzen, M.; Khanna, F. C.; Mann, A.; Zak, J.

2006-05-01

87

Metric Conversion Factors  

NSDL National Science Digital Library

Brought to the Web by Washington State Department of Transportation, the Metric Conversion Factors site contains a wealth of helpful physical science and engineering information. As you might guess, all sorts of conversion factors are presented, such as for area, force, hard conversions for construction materials, length, mass, pavement, pipe, plate, power, pressure or stress, reinforcing steel, sheet metal, sieve, symbols, temperature, volume, and several others. Although it's not an online conversion calculator, all of the pages are set up for efficient printing so that students can have the information with them while doing homework.

88

Tumor necrosis factor signaling  

Microsoft Academic Search

A single mouse click on the topic tumor necrosis factor (TNF) in PubMed reveals about 50 000 articles providing one or the other information about this pleiotropic cytokine or its relatives. This demonstrates the enormous scientific and clinical interest in elucidating the biology of a molecule (or rather a large family of molecules), which began now almost 30 years ago

H Wajant; K Pfizenmaier; P Scheurich

2003-01-01

89

Factor Trail Game  

NSDL National Science Digital Library

In this math game, learners identify the factors of a number to earn points. Although practicing a mundane skill, learners enjoy the work because of the game scenario. Built into this game is cooperative learning--learners check one another's work before points are awarded. This lesson guide includes questions for learners, assessment options, extensions, and reflection questions.

2008-01-01

90

Factors Affecting Internal Blast  

Microsoft Academic Search

Internal blast refers to explosion effects in confined spaces, which are dominated by the heat output of the explosive. Theoretical temperatures and pressures may not be reached due to heat losses and incomplete gas mixing. Gas mixing can have the largest effect, potentially reducing peak quasi-static pressure by a factor of two due to lack of thermal equilibrium between products

R. H. Granholm; H. W. Sandusky; J. E. Felts

2007-01-01

91

FACTORS AFFECTING INTERNAL BLAST  

Microsoft Academic Search

Internal blast refers to explosion effects in confined spaces, which are dominated by the heat output of the explosive. Theoretical temperatures and pressures may not be reached due to heat losses and incomplete gas mixing. Gas mixing can have the largest effect, potentially reducing peak quasi-static pressure by a factor of two due to lack of thermal equilibrium between products

R. H. Granholm; H. W. Sandusky; J. E. Felts

2007-01-01

92

Factors influencing vaccination uptake  

Microsoft Academic Search

Abstract Current Australian research on factors influencing vaccination was discussed at a workshop held at the Royal Alexandra Hospital for Children, Sydney, in March 1998, sponsored by the National Centre for Immunisation Research and Surveillance of Vaccine Preventable Diseases (NCIRS). The application of decision maki ng theory to vaccination behaviour, the expectations and experiences of mothers, and reasons why parents

Edited Jill M Forrest; Margaret A Burgess; Peter B Mcintyre

93

Milestones and Impact Factors  

Microsoft Academic Search

Environmental Health has just received its first Impact Factor by Thomson ISI. At a level of 2.48, this achievement is quite satisfactory and places Environmental Health in the top 25% of environmental science journals. When the journal was launched in 2002, it was still unclear whether the Open Access publishing model could be made into a viable commercial enterprise within

David M Ozonoff; Philippe Grandjean

2010-01-01

94

Factors Affecting Students' Performance  

Microsoft Academic Search

Determinants of students' performance have been the subject of ongoing debate among educators, academics, and policy makers. There have been many studies that sought to examine this issue and their findings point out to hard work, previous schooling, parents’ education, family income and self motivation as factors that have a significant effect on the students GPA. Most of those studies

Nasri Harb; Ahmed El-Shaarawi

2006-01-01

95

Exercise and food factors.  

PubMed

Habitual exercise is beneficial to health as it improves metabolism, reduces the risk of cardiovascular disease, and maintains the immune system. Appropriate nutrition contributes to acceleration of health promotion due to exercise. Recommended daily allowance is elevated by physical activity and intake of various food factors such carbohydrates, proteins, vitamins, minerals, and other phytochemicals is required to avoid their shortage. Additional dietary food factors are effective not only in supplementation to satisfy the allowance but also in further acceleration of the benefits of fitness. Dietary nutrition is also important to maintain active function in the elderly by preventing aging-induced muscle atrophy and avoiding intense exercise-induced disorders. Recently, several food components have been found to show physiological effects, and some of them are considered to be useful for promoting or alternating the beneficial effects of exercise, maintaining homeostasis, and preventing muscle aging. However, some of these food factors should only be used when there is clear scientific evidence. Also, it is important to understand the physiological changes caused by exercise to use them correctly. This article describes various food factors that have been reported to be effective for improving health promotion, along with the relevant physiological changes that occur during exercise. PMID:19367119

Aoi, Wataru

2009-04-07

96

Rugby Fan Attraction Factors  

Microsoft Academic Search

Factors that influence sports fans' game attendance have been researched extensively in USA, Europe and Australia but rather less so in New Zealand. Fans provide the financial success for professional sports organisations, not only in terms of direct revenue from gate-takings, but also indirect revenue from sponsorship, television rights and merchandise. Influence upon rugby union fan attendance over four games

Ron Garland; Terry Macpherson; Kay Haughey

97

Probabilistic Matrix Factorization  

Microsoft Academic Search

Many existing approaches to collaborative filtering can nei ther handle very large datasets nor easily deal with users who have very few ratings. In this paper we present the Probabilistic Matrix Factorization (PMF) model which scales linearly with the number of observations and, more importantly, performs well on the large, sparse, and very imbalanced Netflix dataset. We furth er extend

Ruslan Salakhutdinov; Andriy Mnih

2007-01-01

98

Recombinant factor VIIa.  

PubMed

Human coagulation factor (F) VII is a single chain protease that circulates in the blood as a weakly active zymogen at concentrations of approximately 10 nmol/L. When converted to the active 2 chain form (FVIIa), it is a powerful initiator of haemostasis. Recombinant factor VIIa (rFVIIa, eptacog alfa, NovoSeven) is a genetically engineered product that was first introduced in 1988 for the treatment of patients with haemophilia A and B with high inhibitory antibody titres to factors VIII and IX. Recent reports in the form of case studies and series, and early trial data, have suggested a role for rFVIIa across a diverse range of indications including bleeding associated with trauma, surgery, thrombocytopaenia, liver disease and oral anticoagulant toxicity. This review describes the physiology of the coagulation pathway and in particular the role of recombinant factor VIIa. It will also focus on the emerging role of rFVIIa in both trauma and non-trauma bleeding and its potential use in the ED. PMID:15537408

Aitken, Michael G

99

Limiting Factors in Ecosystems  

NSDL National Science Digital Library

The purpose of this resource is to understand that physical factors - temperature and precipitation - limit the growth of vegetative ecosystems. Students observe and record seasonal changes in their local study site. They establish that these phenomena follow annual cycles and conclude the activity by creating displays that illustrate the repeating pattern associated with the appearance and disappearance of seasonal markers.

The GLOBE Program, University Corporation for Atmospheric Research (UCAR)

2003-08-01

100

ERYTHROPOIETIC FACTOR PURIFICATION  

DOEpatents

A method is given for purifying and concentrating the blood plasma erythropoietic factor. Anemic sheep plasma is contacted three times successively with ion exchange resins: an anion exchange resin, a cation exchange resin at a pH of about 5, and a cation exchange resin at a pH of about 6. (AEC)

White, W.F.; Schlueter, R.J.

1962-05-01

101

Scale Factor X  

NSDL National Science Digital Library

In this game, students navigate a maze to get to a math challenge. The three challenges are: move blue and green "fuel cells" around to match the ratios in the given containers; measure shapes to determine the scale factors needed to make them match the given templates; determine how to place bases on a map based on clues involving proportions.

2010-01-01

102

RNA Polymerase Elongation Factors  

PubMed Central

The elongation phase of transcription by RNA polymerase is highly regulated and modulated. Both general and operon-specific elongation factors determine the local rate and extent of transcription to coordinate the appearance of transcript with its use as a messenger or functional ribonucleoprotein or regulatory element, as well as to provide operonspecific gene regulation.

Roberts, Jeffrey W.; Shankar, Smita; Filter, Joshua J.

2010-01-01

103

Retail Food Risk Factor Studies  

Center for Food Safety and Applied Nutrition (CFSAN)

... Guidance & Regulation. Retail Food Protection. Foodborne Illness & Risk Factor Reduction. -. Retail Food Risk Factor Studies. Backgrounders. ... More results from www.fda.gov/food/guidanceregulation/retailfoodprotection

104

Modified Integer Factorization Algorithm Using V-Factor Method  

Microsoft Academic Search

RSA is the asymmetric cryptography system. The security of RSA public key cryptosystem is based on the assumption that factoring of a large number (modulus). Integer Factorization is an important problem mainly due to its connection with RSA algorihm of Public key cryptography. We present a new special purpose algorithm (VFactor) for factoring. We compare this algorithm with Fermat's Factorization

Prashant Sharma; Amit Kumar Gupta; Ashish Vijay

2012-01-01

105

Factor XI Deficiency.  

PubMed

Severe factor XI (FXI) deficiency is an injury-related bleeding disorder common in Ashkenazi Jews and rare worldwide. In the past two decades, more than 180 mutations in the FXI gene have been reported in patients with FXI deficiency, five of which show a founder effect (Cys38Arg, Gln88Stop, Cys128Stop, Glu117stop, and Phe283Leu, the last two largely prevalent among Ashkenazi Jews). Inhibitors to FXI after exposure to plasma, FXI concentrates, or Rh immunoglobulin were described in patients with mutations resulting in null alleles. Treatment with low-dose recombinant activated factor VII in these patients appears promising. Survival advantages to patients with severe FXI have been recently reported. Herein, we present new observations related to clinic presentation, genotype-phenotype correlation, and treatment problems in patients with FXI deficiency. PMID:19598070

Duga, Stefano; Salomon, Ophira

2009-07-13

106

Factors regulating microglia activation  

PubMed Central

Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the “resting” but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2). Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies. In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence.

Kierdorf, Katrin; Prinz, Marco

2013-01-01

107

Factors regulating microglia activation.  

PubMed

Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the "resting" but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2). Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies. In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence. PMID:23630462

Kierdorf, Katrin; Prinz, Marco

2013-04-23

108

Risk Factors in Stroke  

PubMed Central

In the United States, stroke accounts for 160,000 annual deaths; only 16% of the 1.8 million stroke survivors are fully independent. The incidence of stroke increases with age. Hemorrhagic strokes outnumber ischemic strokes before age 15. Japanese men in this country have a lower stroke mortality than their age peers in Japan. Excessive stroke mortality for US nonwhites may not be entirely due to the greater prevalence of hypertension among blacks. Hypertension emerges as the single most powerful and reversible risk factor in stroke and for survival after stroke. Impaired cardiac function is the second most important precursor of stroke. The recurrence of stroke in survivors is high. The frequency of completed stroke is high in persons with transient ischemic attacks, but not in those with asymptomatic carotid bruits. Other reversible risk factors are smoking, the use of oral contraceptives, alcoholic excess, a low level of physical activity, blood hyperviscosity and drug abuse.

Mustacchi, Piero

1985-01-01

109

Factorization and resummation  

NASA Astrophysics Data System (ADS)

The basic methods of perturbative quantum chromodynamics are introduced and developed through an analysis of short- and long-time dependence in time-ordered perturbation theory for quantum fields. Jet cross sections are shown to be dominated by short times, and hence to be infrared safe. Next, the factorization of short- and long-time dependence for inclusive hard cross sections involving hadrons in the initial state is discussed. The basic results of the parton model, the evolution of deeply inelastic scattering structure functions and the resummation of Sudakov corrections in e+e- annihilation are derived from factorization. The lectures conclude with a brief account of the relation between high orders in perturbation theory and power corrections in e+e- annihilation.

Sterman, George

110

The Fas Death Factor  

Microsoft Academic Search

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction

Shigekazu Nagata; Pierre Golstein

1995-01-01

111

Factoring: The DNA Solution  

Microsoft Academic Search

. We consider molecular models for computing and derive aDNA-based mechanism for solving intractable problems through massiveparallelism. In principle, such methods might reduce the effort neededto solve otherwise difficult tasks, such as factoring large numbers. Weinvestigate the application of such techniques to cryptography.1 IntroductionUntil recently, most computer scientists regarded computational devices as beingessentially the same: according to a complexity-theoretic...

Donald Beaver

1994-01-01

112

R-Factor  

NSDL National Science Digital Library

The amount of energy used in a home is greatly impacted by the type of materials used in constructing the home. In particular, the thermal conductivity of the materials will affect how quickly heat is allowed to enter or leave the home. In this hands-on activity, students will measure the ability of various materials to resist heat flow (R-factor) by placing a light bulb inside boxes made of the materials and monitoring the temperatures both inside and outside.

Pratte, John

2008-12-11

113

Human Factors Review Plan  

SciTech Connect

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01

114

Services - competitiveness factor of tourism  

Microsoft Academic Search

Tourism developement reprezent one of the main priority of modern economies. This evolution depends on factor endowements. They correspond to general factor required for the whole economy and to specific factors to the tourism such as certain natural and cultural resources. Factor endowements can be divided into three categories: natural resouces, historic, artistic and cultural heritage, human resources in employment

Rodica Minciu

2007-01-01

115

Risk Factors for Eating Disorders  

ERIC Educational Resources Information Center

|The authors review research on risk factors for eating disorders, restricting their focus to studies in which clear precedence of the hypothesized risk factor over onset of the disorder is established. They illustrate how studies of sociocultural risk factors and biological factors have progressed on parallel tracks and propose that major…

Striegel-Moore, Ruth H.; Bulik, Cynthia M.

2007-01-01

116

Risk Factors for Eating Disorders  

Microsoft Academic Search

The authors review research on risk factors for eating disorders, restricting their focus to studies in which clear precedence of the hypothesized risk factor over onset of the disorder is established. They illustrate how studies of sociocultural risk factors and biological factors have progressed on parallel tracks and propose that major advances in understanding the etiology of eating disorders require

Ruth H. Striegel-Moore; Cynthia M. Bulik

2007-01-01

117

The activation of plasminogen by Hageman factor (Factor XII) and Hageman factor fragments.  

PubMed Central

Activation of plasminogen through surface-mediated reactions is well recognized. In the presence of kaolin, purified Hageman factor (Factor XII) changed plasminogen to plasmin, as assayed upon a synthetic amide substrate and by fibrinolysis. Kinetic studies suggested an enzymatic action of Hageman factor upon its substrate, plasminogen. Hageman factor fragments, at a protein concentration equivalent to whole Hageman factor, activated plasminogen to a lesser extent. These protein preparations were not contaminated with other agents implicated in surface-mediated fibrinolysis. Diisopropyl fluorophosphate treatment of plasminogen did not inhibit its activation by Hageman factor. These studies indicate that Hageman factor has a hitherto unsuspected function, the direct activation of plasminogen.

Goldsmith, G H; Saito, H; Ratnoff, O S

1978-01-01

118

Factor-multiple Chains  

NSDL National Science Digital Library

This problem offers opportunities for students to reinforce their understanding of factors and multiples and provides them the chance to justify their solutions. The goal is for the students to create number chains of four whole numbers that can range from 2 to 100 and each consecutive number is a multiple of the previous number. The Teachers' Notes page offers suggestions for implementation, key discussion questions, ideas for extension and support, and a link to a spreadsheet for students to experiment with placing numbers in specific boxes in the chain.

2007-04-01

119

Nucleon elastic form factors  

SciTech Connect

The nucleon form factors are still the subject of active investigation even after an experimental effort spanning 50 years. This is because they are of critical importance to our understanding of the electromagnetic properties of nuclei and provide a unique testing ground for QCD motivated models of nucleon structure. Progress in polarized beams, polarized targets and recoil polarimetry have allowed an important and precise set of data to be collected over the last decade. I will review the experimental status of elastic electron scattering from the nucleon along with an outlook for future progress.

D. Day

2007-03-01

120

Femorofemoral bypass: prognostic factors.  

PubMed

During a 17-year period, femorofemoral bypass grafting was performed on 85 patients as the primary operation for unilateral iliac artery disease. Of these patients, 53 (62%) were operated on for claudication and 32 (38%) for limb salvage. There were two operative deaths (2.4%). The 5-year cumulative graft patency rate was 63.2%, and the limb salvage rate was 70%. Prognostic factors included poor runoff and distal disease, donor iliac artery stenosis prior to femorofemoral bypass grafting, and progression of disease in the donor vessel following surgery. Definitive surgical correction is safe and effective with good long-term results. PMID:15227107

Subram, A N; Urrutia-S, C O; Ott, D A; Cooley, D A

1983-09-01

121

Femorofemoral Bypass: Prognostic Factors  

PubMed Central

During a 17-year period, femorofemoral bypass grafting was performed on 85 patients as the primary operation for unilateral iliac artery disease. Of these patients, 53 (62%) were operated on for claudication and 32 (38%) for limb salvage. There were two operative deaths (2.4%). The 5-year cumulative graft patency rate was 63.2%, and the limb salvage rate was 70%. Prognostic factors included poor runoff and distal disease, donor iliac artery stenosis prior to femorofemoral bypass grafting, and progression of disease in the donor vessel following surgery. Definitive surgical correction is safe and effective with good long-term results.

Subram, Aswath N.; Urrutia-S, Carlos O.; Ott, David A.; Cooley, Denton A.

1983-01-01

122

Transcription factor complexes.  

PubMed

Considerable progress has been made during the past year on structural studies of the eukaryotic and bacterial transcription factors that control RNA polymerase function via the formation of multiprotein complexes on promoter DNA. Recently determined structures include negative cofactor 2 recognizing a preformed TATA-box-binding protein-DNA binary complex, a dimer of BmrR bound to both DNA and tetra-phenylphosphonium, DNA-bound complexes of SarA and FadR, leukemia-associated AML1-CBFbeta-DNA ternary complexes and a SAP1-SRF-DNA ternary complex. PMID:11959501

Burley, Stephen K; Kamada, Katsuhiko

2002-04-01

123

Factors regulating cheese shreddability.  

PubMed

Two sets of cheeses were evaluated to determine factors that affect shred quality. The first set of cheeses was made up of 3 commercial cheeses, Monterey Jack, Mozzarella, and process. The second set of cheeses was made up of 3 Mozzarella cheeses with varying levels of protein and fat at a constant moisture content. A shred distribution of long shreds, short shreds, and fines was obtained by shredding blocks of cheese in a food processor. A probe tack test was used to directly measure adhesion of the cheese to a stainless-steel surface. Surface energy was determined based on the contact angles of standard liquids, and rheological characterization was done by a creep and recovery test. Creep and recovery data were used to calculate the maximum and initial compliance and retardation time. Shredding defects of fines and adhesion to the blade were observed in commercial cheeses. Mozzarella did not adhere to the blade but did produce the most fines. Both Monterey Jack and process cheeses adhered to the blade and produced fines. Furthermore, adherence to the blade was correlated positively with tack energy and negatively with retardation time. Mozzarella cheese, with the highest fat and lowest protein contents, produced the most fines but showed little adherence to the blade, even though tack energy increased with fat content. Surface energy was not correlated with shredding defects in either group of cheese. Rheological properties and tack energy appeared to be the key factors involved in shredding defects. PMID:17430914

Childs, J L; Daubert, C R; Stefanski, L; Foegeding, E A

2007-05-01

124

Decryption of tissue factor  

PubMed Central

Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of cell-surface TF activity remains controversial. It has been almost commonly accepted that TF on the cell surface has low (if any) activity, i.e. is encrypted and requires specific conditions/reagents to become active, i.e. decrypted. One of the leading theories suggests that cell membrane lipid composition plays a crucial role in TF decryption, whereas another assigns the key role to the formation of the Cys186-Cys209 disulfide bond. Despite a number of studies published from several laboratories, the role of this bond in the activity of the TF/FVIIa complex remains elusive and controversial. One of the causes of this controversy could be related to the lack of specificity of the reagents used for the cell treatment leading to possible alterations in other cell surface proteins and cell membrane environment. In conclusion, the influence of the Cys186-Cys209 this bond on cell surface TF function remains unclear.

Butenas, Saulius; Krudysz-Amblo, Jolanta

2012-01-01

125

Prognostic factors in neuroblastoma.  

PubMed

Between 1951 and 1978 88 patients under 15 years of age were admitted with the diagnosis of neuroblastoma or ganglioneuroblastoma to the Helsinki University Central Hospital for treatment. The relative importance of various prognostic factors for survival was investigated by the use of the Cox regression analysis and by comparison of adjusted survival curves. In regression analysis prior to classification of the patient sample, stage emerged as the overwhelmingly most significant prognostic variable, while histology and age showed a weaker effect and chemotherapy did not display any effect in this setting. Adjusted comparison of survival curves showed significantly improved survival for patients under one year of age in combined stages III and IV, and for stage III patients treated with combination chemotherapy following non-radical surgery. Thus, while stage is the strongest overall prognostic factor, the effect of age is seen especially in the more advanced cases and the beneficial effect of chemotherapy in the cases where radical operation has not been possible. PMID:3740789

Kajanti, M; Holsti, P

1986-01-01

126

Factors influencing glabridin stability.  

PubMed

Glabridin, a polyphenolic isoflavan of Glycyrrhiza glabra, has shown a variety of pharmaceutical properties. We have previously studied the isolation of glabridin using macroporous resin and found that it is partially degraded, giving a dark color. To illustrate the degradation of glabridin, the present work studied the stability of glabridin under various conditions. Licorice extract containing about 20% glabridin, obtained from G. glabra by silica gel column chromatography, was used in the stability study. Seven different factors (temperature, illumination, humidity, pH, solvent, oxygen, and oxidant) were studied and content changes were determined through HPLC analysis. Except for oxygen, all the above factors had an effect on the stability of glabridin, with illumination being the main one. Moreover, the interactions between temperature and pH, temperature and humidity, and illumination and pH can promote the degradation of glabridin. In conclusion, we suggest that a dark, dry and airtight environment provides the optimized condition for the long-term storage of glabridin. PMID:21299118

Ao, Mingzhang; Shi, Yue; Cui, Yongming; Guo, Wentao; Wang, Jing; Yu, Longjiang

2010-12-01

127

Nuclear Factor One Transcription Factors in CNS Development  

Microsoft Academic Search

Transcription factors are key regulators of central nervous system (CNS) development and brain function. Research in this\\u000a area has now uncovered a new key player–the nuclear factor one (NFI) gene family. It has been almost a decade since the phenotype\\u000a of the null mouse mutant for the nuclear factor one A transcription factor was reported. Nfia null mice display a

Sharon Mason; Michael Piper; Richard M. Gronostajski; Linda J. Richards

2009-01-01

128

Factors Affecting Growth Factor Activity in Goat Milk  

Microsoft Academic Search

Growth factors that are present in goat milk may be responsible for its beneficial effects on the digestive system as described in ancient Chinese medical texts. To develop a nutraceutical product rich in growth fac- tors for promoting gastrointestinal health, it is essen- tial to collect milk with consistently high growth factor activity.Therefore,weinvestigatedthefactorsaffecting growth factor activity in goat milk. Among

F. Y. Wu; P. H. Tsao; D. C. Wang; S. Lin; J. S. Wu; Y. K. Cheng

2006-01-01

129

Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors  

Microsoft Academic Search

Neurotrophins and other neurotrophic factors have been shown to support the survival and differentiation of many neuronal populations of the central and peripheral nervous system. Therefore, administering neurotrophic factors could represent an alternative strategy for the treatment of acute and chronic brain disorders. However, the delivery of neurotrophic factors to the brain is one of the largest obstacles in the

Irina Semkova; Josef Krieglstein

1999-01-01

130

Desafíos laborales en América Latina después de dos décadas de reformas estructurales. Bolivia, Paraguay y Perú 1997-2008  

Microsoft Academic Search

El volumen reune diversos trabajos sobre los mercados laborales en los tres países durante la década comprendida entre 1997 y 2008. En los tres casos se hacen análisis globales de la situación laboral de cada país así como análisis particualres de las áreas rurales y las áreas urbanas. Lo que se encuentra es que los mercados laborales no se habrían

Julio Ramírez; Marcelo Perera; Cynthia González

131

Evaluación de elementos estructurales del hábitat del borrego cimarrón en la Sierra del Mechudo, Baja California Sur, México  

Microsoft Academic Search

Habitat lost and fragmentation can result in an isolated and local extinction risk for small populations like Ovis canadensis weemsi Goldman, 1937, in Sierra del Mechudo, Baja California Sur, Mexico. That is why it is important to evaluate the relationship between species and their habitat in order to design management and conservation plans. The object of this study was to

Sergio Alvarez-Cárdenas; Patricia Galina-Tessaro; Sara Díaz-Castro; Israel Guerrero-Cárdenas; Aradit Castellanos-Vera; Erika Mesa-Zavala

132

Nucleon Electromagnetic Form Factors  

SciTech Connect

There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

2007-10-01

133

Psychosomatic factors in pruritus  

PubMed Central

Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease).

Tey, Hong Liang; Wallengren, Joanna; Yosipovitch, Gil

2013-01-01

134

Perioperative allergy: risk factors.  

PubMed

Perioperative anaphylactic as well as anaphylactoid reactions can be elicited by drugs, diagnostic agents, antiseptics, disinfectants and latex. In some individuals, allergic reactions occur in the absence of any evident risk factor. Previous history of specific safe exposure to a product does not permit to exclude the risk of having a reaction. We have systematically reviewed characteristics in the patient's history or clinical parameters that affect the risk of developing reactions during anesthesia. Evidence shows that patients with previous unexplained reaction during anesthesia are at risk for perioperative allergic reactions. An allergic reaction to an agent is associated with previous reaction to a product that is related with the culprit agent. Multiple surgery procedures, professional exposure to latex and allergy to fruit are associated with an increased frequency of latex allergy. It has been shown that in some instances, allergic perioperative reactions may be more common in atopic patients and in females. PMID:22014923

Caffarelli, C; Stringari, G; Pajno, G B; Peroni, D G; Franceschini, F; Dello Iacono, I; Bernardini, R

135

Psychosomatic factors in pruritus.  

PubMed

Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease). PMID:23245971

Tey, Hong Liang; Wallengren, Joanna; Yosipovitch, Gil

136

Oncogenes, Growth Factors, and Cancer.  

National Technical Information Service (NTIS)

In this taped lecture Dr. Aaronson reviews the biology of several types of oncogene and their interactions with related growth factors and growth factor receptors. He then plots their participation in the regulation of gene expression and in the prolifera...

1994-01-01

137

Factors Affecting New Product Developments.  

National Technical Information Service (NTIS)

Fourteen commercial and 13 Department of Defense (DoD) new product developments are reviewed and analyzed to understand the factors responsible for reducing development times. The major groupings of factors affecting new product developments were found to...

J. T. Shields

1994-01-01

138

Replacements: Units, Service Lives, Factors.  

National Technical Information Service (NTIS)

This report updates the units of property, service lives, replacement factors, service life group percentages, and depreciation rates presented in the reports Replacements (dated March, 1969) and Replacement Factors and Depreciation Rates (dated May, 1969...

J. M. Eyer R. P. Branstetter

1981-01-01

139

Type 2 diabetes - risk factors  

MedlinePLUS

Risk factors for Type 2 diabetes; Diabetes risk factors ... You have a higher risk for diabetes if you have any of the following: Age greater than 45 years Diabetes during a previous pregnancy Excess body weight (especially around ...

140

Environmental factors and aggressive behavior  

SciTech Connect

This paper briefly reviews some of the research areas which indicate a correlation between environmental factors and initiation of aggressive behavior. Environmental factors including lunar influences, month of birth, climate and the effects of crowding and certain chemicals are discussed.

Anderson, A.C.

1982-07-01

141

Wave friction factor rediscovered  

NASA Astrophysics Data System (ADS)

The wave friction factor is commonly expressed as a function of the horizontal water particle semi-excursion ( A wb) at the top of the boundary layer. A wb, in turn, is normally derived from linear wave theory by {{U_{{wb}}/T_{{w}}}}{{2? }} , where U wb is the maximum water particle velocity measured at the top of the boundary layer and T w is the wave period. However, it is shown here that A wb determined in this way deviates drastically from its real value under both linear and non-linear waves. Three equations for smooth, transitional and rough boundary conditions, respectively, are proposed to solve this problem, all three being a function of U wb, T w, and ?, the thickness of the boundary layer. Because these variables can be determined theoretically for any bottom slope and water depth using the deepwater wave conditions, there is no need to physically measure them. Although differing substantially from many modern attempts to define the wave friction factor, the results coincide with equations proposed in the 1960s for either smooth or rough boundary conditions. The findings also confirm that the long-held notion of circular water particle motion down to the bottom in deepwater conditions is erroneous, the motion in fact being circular at the surface and elliptical at depth in both deep and shallow water conditions, with only horizontal motion at the top of the boundary layer. The new equations are incorporated in an updated version (WAVECALC II) of the Excel program published earlier in this journal by Le Roux et al. Geo-Mar Lett 30(5): 549-560, (2010).

Le Roux, J. P.

2012-02-01

142

Reduced titers of Hageman factor (factor XII) in Orientals.  

PubMed

Hageman factor (factor XII) is a procoagulant upon which the surface-mediated generation of fibrinolytic activity and kinin formation depends. We found that the clotpromoting activity and antigenic properties of Hageman factor were present in lower levels in the plasma of a small group of Oriental subjects than in that of American whites, whereas the levels of plasma prekallikrein (Fletcher factor), high-molecular-weight kininogen (Fitzgerald factor), and plasma thromboplastin antecedent (factor XI) in plasma samples from Oriental subjects did not significantly differ from those from normal white subjects. In one family, there was an excess of plasma Hageman factor antigens with respect to functional activity. These findings stress the importance of defining the racial characteristics of subjects used to establish standards for clotting assays. PMID:7305148

Gordon, E M; Donaldson, V H; Saito, H; Su, E; Ratnoff, O D

1981-12-01

143

Phonological Awareness: Factors of Influence  

ERIC Educational Resources Information Center

|Early child development is influenced by various genetic and environmental factors. This study aims to identify factors that affect the phonological awareness of preschool and first grade children. Based on a sample of 330 German-speaking children (mean age = 6.2 years) the following domains were evaluated: Parent factors, birth and pregnancy,…

Frohlich, Linda Paulina; Petermann, Franz; Metz, Dorothee

2013-01-01

144

Computing and Evaluating Factor Scores  

Microsoft Academic Search

A variety of methods for computing factor scores can be found in the psychological literature. These methods grew out of a historic debate regarding the indeterminate nature of the common factor model. Unfortunately, most researchers are unaware of the indeterminacy issue and the problems associated with a number of the factor scoring procedures. This article reviews the history and nature

James W. Grice

2001-01-01

145

Automatic test factoring for java  

Microsoft Academic Search

Test factoring creates fast, focused unit tests from slow system-wide tests; each new unit test exercises only a subset of the functionality exercised by the system test. Augment- ing a test suite with factored unit tests should catch errors earlier in a test run. One way to factor a test is to introduce mock objects. If a test exercises a

David Saff; Shay Artzi; Jeff H. Perkins; Michael D. Ernst

2005-01-01

146

[Factors of female urinary incontinence].  

PubMed

The history, physical examination and complementary investigations must be directed towards analysis of the multiple factors responsible for urinary incontinence, whose relative roles differ from one patient to another. Treatment is primarily directed towards factors which are the easiest to correct. Urethral and vesical factors are summarised in this brief introductory article. PMID:8304750

Susset, J

1993-01-01

147

Factor Analysis via Components Analysis  

ERIC Educational Resources Information Center

|When the factor analysis model holds, component loadings are linear combinations of factor loadings, and vice versa. This interrelation permits us to define new optimization criteria and estimation methods for exploratory factor analysis. Although this article is primarily conceptual in nature, an illustrative example and a small simulation show…

Bentler, Peter M.; de Leeuw, Jan

2011-01-01

148

Quantification of Emission Factor Uncertainty  

EPA Science Inventory

Emissions factors are important for estimating and characterizing emissions from sources of air pollution. There is no quantitative indication of uncertainty for these emission factors, most factors do not have an adequate data set to compute uncertainty, and it is very difficult...

149

Factors facilitating construction industry development  

Microsoft Academic Search

The key factors associated with construction industry development worldwide are identified by using a grounded theory approach. This first involved the identification of 62 variables from earlier studies. A questionnaire survey was then used to elicit views of the current strength of each variable. The resulting data were factor analysed and a set of eight key factors obtained comprising the

Paul Fox; Martin Skitmore

2007-01-01

150

Great Lakes management: Ecological factors  

Microsoft Academic Search

Although attempts to improve the quality of the Great Lakes generally focus on chemical pollution, other factors are important and should be considered Ecological factors, such as invasion of the lakes by foreign species, habitat changes, overfishing, and random variations in organism populations, are especially influential. Lack of appreciation of the significance of ecological factors stems partly from the inappropriate

W. C. Sonzogni; A. Robertson; A. M. Beeton

1983-01-01

151

Psychosocial Factors Affecting Dissertation Completion.  

ERIC Educational Resources Information Center

|Reviews the psychosocial factors associated with doctoral dissertation completion or delay. Examines the effects of two factors, procrastination and perfectionism, in greater detail and reports on a study of 142 education doctoral students and 97 graduates. Notes that educators should consider the role of these psychosocial factors as they help…

Green, Kathy E.

1997-01-01

152

Angiogenic factors as tumor markers  

Microsoft Academic Search

The process of angiogenesis plays a critical role in tumor growth and metastasis. Recently, there has been much interest in the possible use of angiogenic growth factors as tumor markers. This paper will review the results thus far of attempts at measuring various angiogenic factors in bodily fluids. In the future, angiogenic factors will most likely be useful as a

Mai Nguyen

1997-01-01

153

Factor V Leiden and hemophilia  

Microsoft Academic Search

Several inherited prothrombotic risk factors have been identified so far. Among them, the factor V (FV) Leiden mutation causes a reduced ability of activated protein C to inactivate activated FV and is the most frequent genetic predisposing factor for venous thromboembolism. However, the high prevalence of FV Leiden (up to 15%) in the Caucasian population suggests that this mutation might

Massimo Franchini; Giuseppe Lippi

2010-01-01

154

Success factors in key accounts  

Microsoft Academic Search

Purpose – The paper seeks to present research that examines the success factors for key accounts within firms, i.e. what factors lead to successful versus unsuccessful key accounts. Design\\/methodology\\/approach – Data from a consulting firm are analyzed to examine the success factors for key accounts within firms. Findings – The results suggest that marketers' relational assets, personal\\/social bonds, dissatisfaction, and

Arun Sharma

2006-01-01

155

Sample size in factor analysis  

Microsoft Academic Search

In the factor analysis literature, much attention has be;;n given to the issue of sample size. It is widely understood that the use of larger samples in applica- tions of factor analysis tends to provide results such that sample factor loadings are more precise estimates of population loadings and are also more stable, or les s variable, across repeated sampling.

Robert C. MacCallum; Keith F. Widaman; Shaobo Zhang; Sehee Hong

1999-01-01

156

The Human Factor  

NSDL National Science Digital Library

Inspired by ÂÂthe courage, industry and intelligence required of the American working manÂ, two colleagues from the Harvard Business School (Donald Davenport and Frank Ayres) sent out a call to leading businesses in order to develop a visual collection that could be used in the classroom. During the 1930s, they received over 2,100 photographs that documented Âthe human factor embodied in the interactions between worker and machine. Recently, the Baker Library at the Harvard Business School created this online exhibition to showcase a selection of these remarkable images. Visitors should begin by reading the introductory essay; they should then proceed to the exhibition, which is divided into nine sections. Each section begins with a short preface, and then continues on to a sampling of images, which include workers monitoring massive wheels of Swiss cheese in 1933 and a photograph of women assembling parts for Philco radios in 1926. Each photograph can be viewed in great detail, and it is worth noting that the site also contains an exemplary bibliography.

157

Factorizing monolithic applications  

SciTech Connect

The Blanca project is part of the US Department of Energy`s (DOE) Accelerated Strategic Computing Initiative (ASCI), which focuses on Science-Based Stockpile Stewardship through the large-scale simulation of multi-physics, multi-dimensional problems. Blanca is the only Los Alamos National Laboratory (LANL)-based ASCI project that is written entirely in C++. Tecolote, a new framework used in developing Blanca physics codes, provides an infrastructure for gluing together any number of components; this framework is then used to create applications that encompass a wide variety of physics models, numerical solution options, and underlying data storage schemes. The advantage of this approach is that only the essential components for the given model need be activated at runtime. Tecolote has been designed for code re-use and to isolate the computer science mechanics from the physics aspects as much as possible -- allowing physics model developers to write algorithms in a style quite similar to the underlying physics equations that govern the computational physics. This paper describes the advantages of component architectures and contrasts the Tecolote framework with Microsoft`s OLE and Apple`s OpenDoc. An actual factorization of a traditional monolithic application into its basic components is also described.

Hall, J.H.; Ankeny, L.A.; Clancy, S.P. [and others

1998-12-31

158

Rheumatoid factor in Nigerian sera  

PubMed Central

A high prevalence of rheumatoid factor has been found in the sera of apparently healthy inhabitants of two Western Nigerian villages. The prevalence of rheumatoid factor at high titre increased markedly with age. The rheumatoid factor found in the sera of these apparently healthy subjects showed a selective affinity for human ?-globulin rather than rabbit ?-globulin. Rheumatoid factor activity was shown to be restricted to the serum IgM fraction. In one of the two villages a significant correlation was found between the presence of rheumatoid factor at high titre and the presence of IgM malaria antibodies at high titre and the possible role of malaria in the induction of rheumatoid factor formation in these two communities is discussed.

Greenwood, B. M.; Muller, A. S.; Valkenburg, H. A.

1971-01-01

159

Growth factors in synaptic function  

PubMed Central

Synapses are increasingly recognized as key structures that malfunction in disorders like schizophrenia, mental retardation, and neurodegenerative diseases. The importance and complexity of the synapse has fuelled research into the molecular mechanisms underlying synaptogenesis, synaptic transmission, and plasticity. In this regard, neurotrophic factors such as netrin, Wnt, transforming growth factor-? (TGF-?), tumor necrosis factor-? (TNF-?), and others have gained prominence for their ability to regulate synaptic function. Several of these factors were first implicated in neuroprotection, neuronal growth, and axon guidance. However, their roles in synaptic development and function have become increasingly clear, and the downstream signaling pathways employed by these factors have begun to be elucidated. In this review, we will address the role of these factors and their downstream effectors in synaptic function in vivo and in cultured neurons.

Poon, Vivian Y.; Choi, Sojoong; Park, Mikyoung

2013-01-01

160

Risk factors for food allergy  

Microsoft Academic Search

Food allergy is a common problem that often affects young children. Numerous factors affect the development of food allergy\\u000a both prenatally and postnatally. These factors are genetic and environmental. Although little can be done post-conception\\u000a to alter a child’s genetic risk for developing food allergy, early identification may permit alterations of the environment\\u000a in which food allergy develops. Environmental factors

Diane E. Schuller

2004-01-01

161

Risk factors in school shootings.  

PubMed

Nine incidents of multiple-victim homicide in American secondary schools are examined and common risk factors are identified. The literature dealing with individual, family, social, societal, and situational risk factors for youth violence and aggression is reviewed along with existing risk assessment methods. Checklists of risk factors for serious youth violence and school violence are used in reviewing each school shooting case. Commonalties among the cases and implications for psychologists practicing in clinical and school settings are discussed. PMID:10660827

Verlinden, S; Hersen, M; Thomas, J

2000-01-01

162

Factor Proportions, Trade, and Growth  

Microsoft Academic Search

The standard version of the Heckscher-Ohlin model of international trade treats the factors of production--land, labor, and capital--as essentially analytically similar and symmetrical. In these six essays Ronald Findlay explores modifications to the factor proportions model, looking in particular at what happens when human capital and land use are allowed to vary endogenously. Findlay extends the factor proportions theory of

Ronald Findlay

163

Factoring polynomials with rational coefficients  

Microsoft Academic Search

In this paper we present a polynomial-time algorithm to solve the following problem: given a non-zero polynomial fe Q(X) in one variable with rational coefficients, find the decomposition of f into irreducible factors in Q(X). It is well known that this is equivalent to factoring primitive polynomials feZ(X) into irreducible factors in Z(X). Here we call f~ Z(X) primitive if

A. K. Lenstra; H. W. Lenstra; L. Lovfiasz

1982-01-01

164

Acquired Uterine Factors and Infertility  

Microsoft Academic Search

\\u000a Uterine factor subfertility is defined as a structural or functional disorder of the uterus that results in reduced fertility.\\u000a Between one and two percent of in vitro fertilization (IVF) procedures are recorded as being done for uterine factor in the\\u000a United States as reported by Wright et al. (MMWR Surveill Summ 57:1-23, 2008). Live birth rates for isolated uterine factor

Harry H. Hatasaka

165

CELLULAR ORIGIN OF RHEUMATOID FACTOR  

PubMed Central

Fluorescein-labelled aggregated human ?-globulin was found to react in precipitin-type tests with serums of individuals with rheumatoid arthritis. This reagent was also highly reactive and specific for the localization of rheumatoid factor in frozen sections of synovial membranes, lymph nodes, and subcutaneous nodules. In synovial membranes from patients with active rheumatoid arthritis, rheumatoid factor was present in the cytoplasm of plasma cells at various stages of development and maturity. The appearance of the cytoplasm and the occasional presence nearby of extracellular particles suggested the possibility of a secretory process. All other cells were devoid of rheumatoid factor. Some plasma cells contained 7S and/or 19S ?-globulin and many lacked detectable ?-globulin. In lymph nodes from a patient with active rheumatoid arthritis, rheumatoid factor was present in approximately one in ten germinal centers as well as in internodular plasma cells. The rheumatoid factor was localized in the cytoplasm and the characteristic protoplasmic processes of the germinal-center cells. All other cells were devoid of rheumatoid factor. 7S and/or 19S ?-globulin was demonstrated in approximately eight in ten germinal centers in these lymph nodes. Plasma cells with rheumatoid factor were also seen on occasion in rheumatoid subcutaneous nodules. Tissue sections of comparable structure prepared from normal and pathological control material did not contain rheumatoid factor. Staining for rheumatoid factor was blocked by pretreatment of sections either with unlabelled aggregated human ?-globulin or with rabbit antiserum against 19S human ?-globulin.

Mellors, Robert C.; Heimer, Ralph; Corcos, Josue; Korngold, Leonhard

1959-01-01

166

Transcription factor access to chromatin.  

PubMed Central

The question of how sequence-specific transcription factors access their cognate sites in nucleosomally organized DNA is discussed on the basis of genomic footprinting data and chromatin reconstitution experiments. A classification of factors into two categories is proposed: (i) initiator factors which are able to bind their target sequences within regular nucleosomes and initiate events leading to chromatin remodelling and transactivation; (ii) effector factors which are unable to bind regular nucleosomes and depend on initiator factors or on a pre-set nucleosomal structure for accessing their target sequences in chromatin. Studies with the MMTV promoter suggest that the extent and number of protein-DNA contacts determine whether a factor belongs to one or the other category. Initiator factors have only a few DNA contacts clustered on one side of the double helix, whereas effector factors have extensive contacts distributed throughout the whole circumference of the DNA helix. Thus, the nature of DNA recognition confers to sequence-specific factors their specific place in the sequential hierarchy of gene regulatory events.

Beato, M; Eisfeld, K

1997-01-01

167

Regulation of scatter factor production via a soluble inducing factor  

Microsoft Academic Search

Scatter factor (SF) (also known as hepato- cyte growth factor (HGF)) is a fibroblast-derived cytokine that stimulates motility, proliferation, and morphogenesis of epithelia. SF may play major roles in development, repair, and carcinogenesis. However, the physiologic signals that regulate its production are not well delineated. We found that various human tu- mor cell lines that do not produce SF secrete

Eliot M. Rosen; Ansamma Joseph; Liang Jin; Sara Rockwell; Jack A. Elias; Jaromir Knesel; James Wines; Jennifer McClellan; M. J. Kluger; Itzhak D. Goldberg; Ralph Zitnik

1994-01-01

168

Factor Substitution and Unobserved Factor Quality in Nursing Homes  

Microsoft Academic Search

This paper studies factor substitution in one important sector: the nursing home industry. Specifically, we measure the extent to which nursing homes substitute materials for labor when labor becomes relatively more expensive. From a policy perspective, factor substitution in this market is important because materials-intensive methods of care are associated with greater risks of morbidity and mortality among nursing home

John Cawley; David C. Grabowski; Richard A. Hirth

2004-01-01

169

Women's Career Success: A Factor Analytic Study of Contributing Factors.  

ERIC Educational Resources Information Center

A survey of 466 women employed in retailing received 205 responses identifying (1) factors influencing the success and advancement of women in retailing and (2) how those factors differ for women in upper versus middle positions. Upper-level executives placed more importance on ambition and abilities; midlevel executives credited opportunity and…

Gaskill, LuAnn Ricketts

1991-01-01

170

Protective Factors as Moderators of Risk Factors in Adolescence Bullying  

Microsoft Academic Search

The present study examined the role played by protective factors in moderating the effects of risk factors over bullying and victimization in a sample of 679 male adolescents recruited in Italian high schools. Boys’ involvement in bullying revealed that one in three students has bullied others at least sometimes in the previous three months, and one in six has been

Anna C. Baldry; David P. Farrington

2005-01-01

171

Protective Factors and Risk Factors in Preschool Aged Children  

Microsoft Academic Search

Do resiliency or protective factors moderate risk factors in preschool aged children? This study looks at pre- and post-treatment data from 49 preschool children whose average age was 4 years old. The treatment included prevention and early intervention programs that promote emotional well-being and the development of healthy interpersonal relationships in children, ages birth to eight, and their caregivers. The

Monica R. Geist; P. Antonio; Olmos Gallo; Mary Grimmer; Daniel J. Mundfrom

2006-01-01

172

Smoking – A Renal Risk Factor  

Microsoft Academic Search

One of the most important tasks of clinical and experimental nephrology is to identify the risk factors of progression of renal failure. A major renal risk factor which has not been sufficiently acknowledged despite increasing evidence is cigarette smoking. Diabetologists were the first to recognize the adverse effects of smoking on the kidney: both in type 1 and in type

Stephan R. Orth

2000-01-01

173

Risk factors for proliferative vitreoretinopathy  

Microsoft Academic Search

Proliferative vitreoretinopathy (PVR) is one of the major causes of failure in retinal detachment surgery. To prevent PVR, it is necessary to determine factors predisposing its development. In primary PVR, large retinal tears, long duration of retinal detachment, vitreous hemorrhages, aphakia and choroidal detachment were demonstrated as clinical risk factors for PV R. In postoperative PVR, it was revealed that

Hiroshi Nagasaki; Kouichi Shinagawa; Manabu Mochizuki

1998-01-01

174

Genetic factors in anorexia nervosa  

Microsoft Academic Search

Anorexia nervosa is a severe and complex disorder with incompletely known vulnerability factors. It is generally recognized that anorexia nervosa is a familial disorder, but the majority of twin studies have shown that the concordance rate for monozygotic twins is higher (on average 44%) than for dizygotic twins (on average 12.5%). This difference in concordance rates shows that genetic factors,

A Kipman; P Gorwood; M. C Mouren-Siméoni; J Adès

1999-01-01

175

Virulence factors of Cryptococcus neoformans  

Microsoft Academic Search

Cryptococcosis is a serious fungal disease in patients with AIDS or other defects in T-cell-mediated host defenses. Cryptococcus neoformans produces several virulence factors, most notably the polysaccharide capsule and phenol oxidase. Molecular studies of cryptococcal virulence factors have contributed to our understanding of the pathobiology of this yeast, and will enable the identification of new targets for antifungal therapy.

Thomas R Kozel

1995-01-01

176

The factors influencing childrens’ drawings  

Microsoft Academic Search

Drawings are an important part of child's life. Children can describe their happiness, unhappiness, future dreams, past lives and continuing lives as they want through their drawings. The factors influencing children's drawings can be grouped under two main categories. They are; (1) the factors which are specific to child (species-specific readiness, maturation, age, intelligence, motivation, general state of arousal and

Vuslat O?uz

2010-01-01

177

Scale factor in digital cameras  

NASA Astrophysics Data System (ADS)

For objects on a plane, a "scale factor" relates the physical dimensions of the objects to the corresponding dimensions in a camera image. This scale factor may be the only calibration parameter of importance in many test applications. The scale factor depends on the angular size of a pixel of the camera, and also on the range to the object plane. A measurement procedure is presented for the determination of scale factor to high precision, based on the translation of a large-area target by a precision translator. A correlation analysis of the images of a translated target against a reference image is used to extract image shifts and the scale factor. The precision of the measurement is limited by the translator accuracy, camera noise and various other secondary factors. This measurement depends on the target being translated in a plane perpendicular to the optic axis of the camera, so that the scale factor is constant during the translation. The method can be extended to inward-looking 3D camera networks and can, under suitable constraints, yield both scale factor and transcription angle.

Badali, Anthony P.; Zhang, Yahui; Carr, Peter; Thomas, Paul J.; Hornsey, Richard I.

2005-09-01

178

Exogenous Factors in Hair Disorders  

Microsoft Academic Search

The health and beauty of human hair have immeasurable psychological importance. Hair structure and its cycle are influenced by intentionally or nonintentionally delivered factors such as grooming, heat styling, chemical agents and climatic exposure. All of these factors are capable of causing loss of hair color and luster, harshness, stiffness, weakness, brittleness and flyaway, transient loss of hair or scarring

Liran Horev

2004-01-01

179

Prognostic factors in acute pancreatitis  

Microsoft Academic Search

Prognostic factor scoring systems provide one method of predicting severity of acute pancreatitis. This paper reports the prospective assessment of a system using nine factors available within 48 hours of admission. This assessment does not include patient data used to compile the system. Of 405 episodes of acute pancreatitis occurring in a seven year period, 72% had severity correctly predicted

S L Blamey; C W Imrie; J ONeill; W H Gilmour; D C Carter

1984-01-01

180

Smooth stabilization implies coprime factorization  

Microsoft Academic Search

This paper shows that coprime right factorizations exist for the input to state mapping of a continuous time nonlinear system provided that the smooth feedback stabilization problem be solvable for this system. In particular, it follows that feedback linearizable systems admit such factorizations. In order to establish the result a Lyapunov-theoretic denition is proposed for \\\\bounded input bounded output\\

Eduardo D. Sontag

1989-01-01

181

Algorithms for Nonnegative Matrix Factorization  

Microsoft Academic Search

Non-negative matrix factorization (NMF) has previously been shown to be a useful decomposition for multivariate data. Two different multi- plicative algorithms for NMF are analyzed. They differ only slightly in the multiplicative factor used in the update rules. One algorithm can be shown to minimize the conventional least squares error while the other minimizes the generalized Kullback-Leibler divergence. The monotonic

Daniel D. Lee; H. Sebastian Seung

2000-01-01

182

Factoring Polynomials with Rational Coefficients.  

National Technical Information Service (NTIS)

A polynomial-time algorithm for the factorization of polynomials in one variable with rational coefficients is described. First a suitable small prime number p is found, a p-adic irreducible factor h of the polynomial f. This is done with Berlekamp's algo...

A. K. Lenstra H. W. Lenstra L. Lovasz

1982-01-01

183

EXPOSURE FACTORS HANDBOOK PROJECT OVERVIEW  

EPA Science Inventory

The Exposure Factors Handbook (EPA/600/P-95/002Fa-Fc) was published in August 1997. The Handbook provides summary statistical data on exposure factors necessary to assess human exposures to environmental contaminants. New data and studies have become available since 1997. The ...

184

Remarks on form factor bounds  

SciTech Connect

Improved model independent upper bounds on the weak transition form factors are derived using inclusive sum rules. A comparison of the new bounds with the old ones is made for the form factors h{sub A{sub 1}} and h{sub V} in B{yields}D{sup *} decays. (c) 2000 The American Physical Society.

Chiang, Cheng-Wei [Department of Physics, Carnegie Mellon University, Pittsburgh, Pennsylvania 15213 (United States)

2000-03-01

185

Knockout, Transfer and Spectroscopic Factors  

NASA Astrophysics Data System (ADS)

As derived quantities rather than observables, spectroscopic factors extracted from fits to data are model dependent. The main source of uncertainty is the choice of binding potential, but other factors such as adequate modeling of the reaction mechanism, the Perey effect, choice of distorting nuclear potentials etc. can also play a significant role. Recently, there has been some discussion of apparent discrepancies in spectroscopic factors derived from knockout reactions compared to those obtained from low-energy direct reactions. It should be possible to reconcile these discrepancies and we explore this prospect by attempting to describe the ^10Be(d,t)^9Be data of Nucl. Phys. A157, 305 (1970) using the ^10Be/^9Be form factors from a recent knockout study, Phys. Rev. Lett. 106, 162502 (2011). The influence of such factors as choice of distorting potentials and multi-step reactions paths will be explored.

Kemper, Kirby; Keeley, Nicholas; Rusek, Krzysztof

2011-10-01

186

Optimizing human factors in dentistry  

PubMed Central

Occupational health hazards among dental professionals are on a continuous rise and they have a significant negative overall impact on daily life. This review is intended to provide the information regarding risk factors and to highlight the prevention strategies for optimizing human factors in dentistry. Risk factors among dentists are multifactorial, which can be categorized into biomechanical and psychosocial. To achieve a realistic target of safety and health at work, prevention is clearly the best approach; therefore, musculoskeletal disorders can be reduced through proper positioning of dental worker and patient, regular rest breaks, general good health, using ergonomic equipment, and exercises designed to counteract the particular risk factors for the dental occupation. However, substantial evidences are still required to elucidate the potential risk factors and to formulate effective prevention programs.

Gupta, Arpit; Ankola, Anil V.; Hebbal, Mamata

2013-01-01

187

Optimizing human factors in dentistry.  

PubMed

Occupational health hazards among dental professionals are on a continuous rise and they have a significant negative overall impact on daily life. This review is intended to provide the information regarding risk factors and to highlight the prevention strategies for optimizing human factors in dentistry. Risk factors among dentists are multifactorial, which can be categorized into biomechanical and psychosocial. To achieve a realistic target of safety and health at work, prevention is clearly the best approach; therefore, musculoskeletal disorders can be reduced through proper positioning of dental worker and patient, regular rest breaks, general good health, using ergonomic equipment, and exercises designed to counteract the particular risk factors for the dental occupation. However, substantial evidences are still required to elucidate the potential risk factors and to formulate effective prevention programs. PMID:23946745

Gupta, Arpit; Ankola, Anil V; Hebbal, Mamata

2013-03-01

188

Investigating Factors that Influence Climate  

NSDL National Science Digital Library

There are several factors that influence the climate or prevailing weather conditions for any given location on Earth. The most important factor is the latitude of the location because that affects the amount of solar radiation received throughout the year. Other factors include its distance from a body of water (its moisture source), elevation and local topography. In this 6 to 10 day unit plan, students will employ inquiry methods to investigate how latitude and longitude (and distance from oceans) impact climatic factors such as temperature range, average temperature, and precipitation. They will create climatic diagrams called climatograms that allow them to display monthly average weather conditions such as temperature and precipitation at a particular location. They will then use the data to design an investigation about the factors that influence climate.

189

Mitotic bookmarking by transcription factors  

PubMed Central

Mitosis is accompanied by dramatic changes in chromatin organization and nuclear architecture. Transcription halts globally and most sequence-specific transcription factors and co-factors are ejected from mitotic chromatin. How then does the cell maintain its transcriptional identity throughout the cell division cycle? It has become clear that not all traces of active transcription and gene repression are erased within mitotic chromatin. Many histone modifications are stable or only partially diminished throughout mitosis. In addition, some sequence-specific DNA binding factors have emerged that remain bound to select sites within mitotic chromatin, raising the possibility that they function to transmit regulatory information through the transcriptionally silent mitotic phase, a concept that has been termed “mitotic bookmarking.” Here we review recent approaches to studying potential bookmarking factors with regards to their mitotic partitioning, and summarize emerging ideas concerning the in vivo functions of mitotically bound nuclear factors.

2013-01-01

190

Great Lakes management: Ecological factors  

NASA Astrophysics Data System (ADS)

Although attempts to improve the quality of the Great Lakes generally focus on chemical pollution, other factors are important and should be considered Ecological factors, such as invasion of the lakes by foreign species, habitat changes, overfishing, and random variations in organism populations, are especially influential. Lack of appreciation of the significance of ecological factors stems partly from the inappropriate application of the concept of eutrophication to the Great Lakes. Emphasis on ecological factors is not intended to diminish the seriousness of pollution, but rather to point out that more cost-effective management, as well as more realistic expectations of management efforts by the public, should result from an ecosystem management approach in which ecological factors are carefully considered.

Sonzogni, W. C.; Robertson, A.; Beeton, A. M.

1983-11-01

191

What Are the Risk Factors for Rhabdomyosarcoma?  

MedlinePLUS

... know what causes rhabdomyosarcoma? What are the risk factors for rhabdomyosarcoma? A risk factor is anything that affects the chance of having ... such as cancer. Different cancers have different risk factors. Lifestyle-related risk factors such as body weight, ...

192

Based on factor analysis of influencing factors of port throughput  

NASA Astrophysics Data System (ADS)

Throughput of port is an important quantitative indicator reflecting the port producing and managing results, while it's also an important quantitative indicator of the construction of international shipping center of Shanghai. Besides, throughput of port is a quantitative reference measuring the level of development and construction of a country, region or a city. There are many factors affecting the. From several throughput of port affecting factors, in this article, with the help of SSRS13.0, we used factor analysis based on empirical analysis of Shanghai to extract fatal factors and analyze the inherent mechanism of throughput of port, and aimed to make some suggestions for the establishment of international shipping center of Shanghai.

Yuan, Xiang

2011-10-01

193

Environmental risk factors for autism  

PubMed Central

Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among the increasingly seen examples in which there is a fetal basis for later disease or disorder. Environmental, genetic, and epigenetic factors all play a role in determining the risk of autism and some of these effects appear to be transgenerational. Identification of the most critical windows of developmental vulnerability is paramount to understanding when and under what circumstances a child is at elevated risk for autism. No single environmental factor explains the increased prevalence of autism. While a handful of environmental risk factors have been suggested based on data from human studies and animal research, it is clear that many more, and perhaps the most significant risk factors, remain to be identified. The most promising risk factors identified to date fall within the categories of drugs, environmental chemicals, infectious agents, dietary factors, and other physical/psychological stressors. However, the rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition. For the way forward, it seems clear that additional focused research is needed. But more importantly, successful risk reduction strategies for autism will require more extensive and relevant developmental safety testing of drugs and chemicals.

Dietert, Rodney R.; Dietert, Janice M.; Dewitt, Jamie C.

2010-01-01

194

Factorization in exclusive quarkonium production  

SciTech Connect

We present factorization theorems for two exclusive heavy-quarkonium production processes: production of two quarkonia in e{sup +}e{sup -} annihilation and production of a quarkonium and a light meson in B-meson decays. We describe the general proofs of factorization and supplement them with explicit one-loop analyses, which illustrate some of the features of the soft-gluon cancellations. We find that violations of factorization are generally suppressed relative to the factorized contributions by a factor v{sup 2}m{sub c}/Q for each S-wave charmonium and a factor m{sub c}/Q for each L-wave charmonium with L>0. Here, v is the velocity of the heavy quark or antiquark in the quarkonium rest frame, Q={radical}(s) for e{sup +}e{sup -} annihilation, Q=m{sub B} for B-meson decays, {radical}(s) is the e{sup +}e{sup -} center-of-momentum energy, m{sub c} is the charm-quark mass, and m{sub B} is the B-meson mass. There are modifications to the suppression factors if quantum-number restrictions apply for the specific process.

Bodwin, Geoffrey T.; Garcia i Tormo, Xavier; Lee, Jungil [High Energy Physics Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439 (United States); High Energy Physics Division, Argonne National Laboratory, 9700 South Cass Avenue, Argonne, Illinois 60439, USA and Department of Physics, University of Alberta, Edmonton, Alberta, T6G 2G7 (Canada); Department of Physics, Korea University, Seoul 136-701 (Korea, Republic of)

2010-06-01

195

Human Factors Influencing Decision Making.  

National Technical Information Service (NTIS)

This report supplies references and comments on literature that identifies human factors influencing decision making, particularly military decision making. The literature has been classified as follows (the classes are not mutually exclusive): features o...

P. A. Jacobs D. P. Gaver

1998-01-01

196

Highly Parallel Sparse Cholesky Factorization.  

National Technical Information Service (NTIS)

Several fine grained parallel algorithms were developed and compared to compute the Cholesky factorization of a sparse matrix. The experimental implementations are on the Connection Machine, a distributed memory SIMD machine whose programming model concep...

J. R. Gilbert R. Schreiber

1990-01-01

197

Highly Parallel Sparse Cholesky Factorization.  

National Technical Information Service (NTIS)

The paper develops and compares several fine-grained parallel algorithms to compute the Cholesky factorization of a sparse matrix. The experimental implementations are on the Connection Machine, a distributed-memory SIMD machine whose programming model co...

J. R. Gilbert R. Schreiber

1990-01-01

198

Factors influencing dust suppressant effectiveness  

SciTech Connect

Water sprays are a common method used to reduce particulate matter (PM) emissions. Various factors such as wettability, surface area coverage, fine particle engulfment rates, interparticle adhesion forces, suppressant penetration and suppressant longevity have all been suggested as critical factors in achieving effective PM control. However, it has not been established which of these factors are the most important. Experimental work indicated that suppressant penetration is the most critical of these factors. The length of time after application that suppressants were effective was also improved by using hygroscopic reagents that retained moisture to prevent evaporation. Maximizing suppressant penetration and improving suppressant longevity led to an average 86% reduction in PM10 concentrations in laboratory dust tower tests.

Copeland, C.R.; Eisele, T.C.; Chesney, D.J.; Kawatra, S.K. [Michigan Technology University, Houghton, MI (United States). Dept. of Chemical Engineering

2008-11-15

199

New Results on Integer Factorizations.  

National Technical Information Service (NTIS)

The study of the crypto-security of the RSA algorithm at Sandia National Laboratories has focused attention on factorization of large integers, as no attack of lesser computational complexity has thus far surfaced. This report describes recent experience ...

J. A. Davis D. B. Holdridge

1984-01-01

200

Lattices and Factorization of Polynomials.  

National Technical Information Service (NTIS)

An algorithm to factorize polynomials over an algebraic number field is presented. Unlike other algorithms, the efficiency of the method does not depend on the irreducibility of the minimal polynomial modulo some prime. The algorithm is based on a theorem...

A. K. Lenstra

1981-01-01

201

Factors Modulating Estrogen Receptor Activity.  

National Technical Information Service (NTIS)

Our goal to elucidate the molecular mechanisms of transcriptional regulation by the estrogen receptor alpha (ER) in breast cancer. ER is a hormone-dependent transcription factor involved in the regulation of both normal and malignant breast cell growth by...

M. Garabedian

2000-01-01

202

Prognostic Factors in Breast Cancer.  

National Technical Information Service (NTIS)

The independent value of gross and histologic examination, S-phase determination, microvessel density and immunohistochemical expression of epidermal growth factor receptor (egfr), her2lneu, Ki-67 (a proliferation marker), estrogen and progesterone recept...

J. Seidman

1995-01-01

203

Form factors and photoproduction amplitudes  

SciTech Connect

We examine the use of phenomenological form factors in tree level amplitudes for meson photoproduction. Two common recipes are shown to be fundamentally incorrect. An alternate form consistent with gauge invariance and crossing symmetry is proposed.

Davidson, R. M.; Workman, Ron

2001-02-01

204

Environmental Factors Inducing Human Cancers  

PubMed Central

Background An explosion of research has been done in discovering how human health is affected by environmental factors. I will discuss the impacts of environmental cancer causing factors and how they continue to cause multiple disruptions in cellular networking. Some risk factors may not cause cancer. Other factors initiate consecutive genetic mutations that would eventually alter the normal pathway of cellular proliferations and differentiation. Genetic mutations in four groups of genes; (Oncogenes, Tumor suppressor genes, Apoptosis genes and DNA repairing genes) play a vital role in altering the normal cell division. In recent years, molecular genetics have greatly increased our understanding of the basic mechanisms in cancer development and utilizing these molecular techniques for cancer screening, diagnosis, prognosis and therapies. Inhibition of carcinogenic exposures wherever possible should be the goal of cancer prevention programs to reduce exposures from all environmental carcinogens.

Parsa, N

2012-01-01

205

Temporal Factors in Subjective Color.  

National Technical Information Service (NTIS)

The Memorandum provides a synopsis of what is known about subjective-color sensations produced by temporal factors in the retinal luminous stimulus. Four principal psychophysical phenomena or effects involved in subjective color are identified and discuss...

J. J. Sheppard

1966-01-01

206

Toxicity Equivalency Factors for PCBs.  

National Technical Information Service (NTIS)

In December 1990 the U.S. Environmental Protection Agency sponsored a workshop to discuss the applicability of an interim 'toxicity equivalency factor' (TEF) approach to assessing risks posed by exposures to complex mixtures of polychlorinated biphenyls (...

D. Barnes A. Alford-Stevens L. Birnbaum F. W. Kutz W. Wood

1991-01-01

207

Nonspecific Host Factors - A Review.  

National Technical Information Service (NTIS)

Since nutritional abnormalities can alter both nonspecific and specific cellular and humoral immune defenses, we must improve our understanding of their complex interrelationships. This chapter provides a review of the various nonspecific factors (Table 1...

W. R. Beisel

1976-01-01

208

Coagulation Factor IX (Human) (Mononine)  

Center for Biologics Evaluation and Research (CBER)

... and Usage section of the PI, is intended for the prevention and control of bleeding in Factor IX deficiency, also known as Hemophilia B or Christmas ... More results from www.fda.gov/biologicsbloodvaccines/guidancecomplianceregulatoryinformation/complianceactivities

209

Predisposition Factors in Anorexia Nervosa.  

ERIC Educational Resources Information Center

|Reviews literature concerned with investigating psychiatric disturbances and genetic variables hypothesized as predisposing factors in etiology of anorexia nervosa. Gives particular emphasis to research which discusses association between anorexia nervosa and depression. Reviews psychopharmacological evidence and family genetics studies. Offers…

Nagel, K. L.; Jones, Karen H.

1992-01-01

210

Integer Factoring Utilizing PC Cluster  

Microsoft Academic Search

\\u000a The integer factoring problem is one of the oldest and important problems and it is considered as hard, i.e., the problem\\u000a cannot be solved in polynomial time for the worst case, because the security of RSA is heavily dependent on the difficulties\\u000a of integer factoring. As is well known, hardware technology is progressing rapidly from year to year and it

Kazumaro Aoki

2006-01-01

211

Growth Factors and Neuropathic Pain  

Microsoft Academic Search

A treatment for neuropathic pain is an important unmet medical need because this pain often is refractory to many medical\\u000a interventions. An important element in the development of neuropathic pain is a dysfunction in the activity of peripheral\\u000a nerves. Because neurotrophic factors affect nerve development and maintenance, modulating the activity of these factors can\\u000a alter neuronal pathophysiology and produce a

Michael H. Ossipov

2011-01-01

212

Structure of human factor VIII  

Microsoft Academic Search

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation

Gordon A. Vehar; Bruce Keyt; Dan Eaton; Henry Rodriguez; Donogh P. O'Brien; Frances Rotblat; Herman Oppermann; Rodney Keck; William I. Wood; Richard N. Harkins; Edward G. D. Tuddenham; Richard M. Lawn; Daniel J. Capon

1984-01-01

213

Risk factors for pathological gambling  

Microsoft Academic Search

To better understand pathological gambling, potential risk factors were assessed within three domains—gambling behaviors, substance abuse and other problem behaviors, and sociodemographic factors. A random-digit-dial telephone survey was conducted in 1999–2000 with a representative sample of the U.S. population aged 18 or older. The current analyses uses data from the 2168 respondents who gambled in the year before the interview.

John W. Welte; Grace M. Barnes; William F. Wieczorek; Marie-Cecile O. Tidwell; John C. Parker

2004-01-01

214

Neighborhood Risk Factors for Obesity  

Microsoft Academic Search

Objective: The goal of this study was to explore neighborhood environmental factors associated with obesity in a sample of adults living in a major U.S. metropolitan area.Research Methods and Procedures: This was a multi-level study combining data from the U.S. Behavioral Risk Factor Surveillance System with data from the U.S. Census. A total of 15,358 subjects living in 327 zip

Russ P. Lopez

2007-01-01

215

What Are Trade Pull Factors?  

Microsoft Academic Search

There were ten counties that have trade pull factors scoring between the range of 0.80 - 1.00. These counties are shaded in light blue on the county trade pull factor map, namely Kay (0.97), Pontotoc (0.93), Jackson (0.92), Comanche (0.91), Muskogee (0.90), Woods (0.89), Cleveland & Stephens (0.86), Pittsburg (0.84), and Pottawatomie (0.80). With the exception of

Fui Phang; Shamus Moore

2009-01-01

216

Viscoelastic stress-concentration factors  

Microsoft Academic Search

Through the use of a new photoviscoelastic material, stereospecific polybutadiene, an exploratory photomechanical investigation was made of viscoelastic stress-concentration factors in bars loaded in dead-weight tension. Despite large creep deformations of the originally circular holes and circular arc fillets in the bars, the stress-concentration factors were observed to change by only about 25 percent of the initial values, which were

H. Becker; R. Papirno

1968-01-01

217

Thinking beyond the risk factors.  

PubMed

For each risk factor for Black Death he discovered, John Graunt in 1662 made a recommendation for action, such as fleeing the night air brought to the City of London docks on foreign ships. These stopped the plague for 200 years! In this honored guest lecture, I focus on thinking beyond the risk factors to their neutralization by effective action without waiting for perfect knowledge of mechanisms. For example, the decreasing risk of repairing atrioventricular septal defect resulted from risk factors that stimulated focused research to devise a better operation. General reduction in risk reduced mortality of aortic valve replacement in patients with chronic aortic regurgitation and severe left ventricular dysfunction. Optimal timing of surgery after stabilizing patients reduced risk of the Norwood procedure. Managing intractable cardiogenic shock reduced risk-adjusted mortality in post-infarct ventricular septal defect. However, we must think beyond traditional risk factors to neutralization of those brought by patient characteristics, imponderables, treatment delivery systems, institutions delivering care to groups of patients, and society caring for its population. There are limitations to thinking beyond risk factors. First, neutralizing strategies require improving processes or introducing new ones. Yet there may be process-outcome disconnect, or even counterintuitive or contradictory relations among outcomes and what are thought to be best processes. Nevertheless, thinking beyond risk factors to their neutralization by research, innovation, and application of knowledge can be as spectacularly successful as was fleeing foul air in halting Black Death. PMID:16616854

Blackstone, Eugene H

2006-04-17

218

Human factors in occupational medicine.  

PubMed

Physicians should be knowledgeable of human factors (ergonomics) to address the workplace needs of their patients. Human factors is the discovery and application of principles concerning human capacities and capabilities to the design, evaluation, operation, and maintenance of the work system for the safe, effective, and satisfying use by people. Human factors encompasses a wide range of subjects that relate to the mutual interaction between the worker and the work system, which includes the following: the organization, the environment, and the workplace; the job and the tasks the worker performs; and the equipment and the tools used. The majority of work-related injuries and loss incidents have some contributory cause related to the interaction between the worker and the work system. The goal of human factors activities is to assess abnormal or excessive human stressors and minimize or eliminate the stress to improve performance and reliability and minimize error. Human factors is becoming an integral part of occupational medicine because it is increasingly important in the workplace. This overview of human factors emphasizes the current knowledge of prevention and intervention measures to enhance the functional quality of the workplace. PMID:8331440

Budnick, L D

1993-06-01

219

Structural Biology Of Factor VIIa/Tissue Factor Initiated Coagulation  

PubMed Central

Factor VII (FVII) consists of an N-terminal gamma-carboxyglutamic acid domain followed by two epidermal growth factor-like (EGF1 and EGF2) domains and the C-terminal protease domain. Activation of FVII results in a two-chain FVIIa molecule consisting of a light chain (Gla-EGF1-EGF2 domains) and a heavy chain (protease domain) held together by a single disulfide bond. During coagulation, the complex of tissue factor (TF, a transmembrane glycoprotein) and FVIIa activates factor IX (FIX) and factor X (FX). FVIIa is structurally “zymogen-like” and when bound to TF, it is more “active enzyme-like.” FIX and FX share structural homology with FVII. Three structural biology aspects of FVIIa/TF are presented in this review. One, regions in soluble TF (sTF) that interact with FVIIa as well as mapping of Ca2+, Mg2+, Na+ and Zn2+ sites in FVIIa and their functions; two, modeled interactive regions of Gla and EGF1 domains of FXa and FIXa with FVIIa/sTF; and three, incompletely formed oxyanion hole in FVIIa/sTF and its induction by substrate/inhibitor. Finally, an overview of the recognition elements in TF pathway inhibitor is provided.

Vadivel, Kanagasabai; Paul Bajaj, S.

2012-01-01

220

Factorization, power corrections, and the pion form factor  

NASA Astrophysics Data System (ADS)

This paper is an investigation of the pion form factor utilizing recently developed effective field theory techniques. The primary results reported are both the transition and electromagnetic form factors are corrected at order ?/Q due to time ordered products which account for deviations of the pion from being a state composed purely of highly energetic collinear quarks in the lab frame. The usual higher twist wave function corrections contribute only at order ?2/Q2, when the quark mass vanishes. In the case of the electromagnetic form factor the ?/Q power correction is enhanced by a power of 1/?s(Q) relative to the leading order result of Brodsky and Lepage, if the scale ?(?Q) is nonperturbative. This enhanced correction could explain the discrepancy with the data.

Rothstein, Ira Z.

2004-09-01

221

Factorization for generic jet production  

SciTech Connect

Factorization is the central ingredient in any theoretical prediction for collider experiments. We introduce a factorization formalism that can be applied to any desired observable, like event shapes or jet observables, for any number of jets and a wide range of jet algorithms in leptonic or hadronic collisions. This is achieved by using soft-collinear effective theory to prove the formal factorization of a generic fully differential cross section in terms of a hard coefficient, and generic jet and soft functions. In this formalism, whether a given observable factorizes in the usual sense, depends on whether it is inclusive enough, so the jet functions can be calculated perturbatively. The factorization formula for any such observable immediately follows from our general result, including the precise definition of the jet and soft functions appropriate for the observable in question. As examples of our formalism, we work out several results in two-jet production for both e{sup +}e{sup -} and pp collisions. For the latter, we also comment on how our formalism allows one to treat underlying events and beam remnants.

Bauer, Christian W.; Hornig, Andrew; Tackmann, Frank J. [Ernest Orlando Lawrence Berkeley National Laboratory, University of California, Berkeley, California 94720 (United States)

2009-06-01

222

Matrix Metalloproteinases and Angiogenic Factors  

PubMed Central

The aim of the present study was to investigate whether biomarkers improve the prediction of recurrence-free, disease-specific, and overall survival in patients with clinically localized prostate cancer. A tissue microarray was constructed from prostate specimens of 278 patients who underwent open radical retropubic prostatectomy for clinically localized prostate cancer. For immunohistochemical studies, antibodies were used against matrix metalloproteinase (MMP)?2, MMP-3, MMP-7, MMP-9, MMP-13, and MMP-19, as well as against vascular endothelial growth factor, hypoxia-induced factor 1?, basic fibroblast growth factor, and cluster of differentiation 31. Univariate and multivariable analyses were performed to evaluate the potential predictors of overall, disease-specific, and recurrence-free survival. In univariate analysis of patients with clinically organ-confined prostate cancer, only higher expression levels of MMP-9 (hazard ratio [0.6], 95% CI 0.45?0.8) had a protective effect in terms of overall survival. This positive effect of high MMP-9 expression was also observed for recurrence-free (HR 0.88, 95% CI 0.78?0.99) and disease-specific survival (HR 0.5, 95% CI 0.36?0.73). In multivariable analysis, none of these potential markers was found to be an independent prognostic factor of survival. Of all MMPs and angiogenic factors tested, MMP-9 expression has the potential as a prognostic marker in patients undergoing radical prostatectomy for clinically organ-confined cases of prostate cancer.

Boxler, Silvan; Djonov, Valentin; Kessler, Thomas M.; Hlushchuk, Ruslan; Bachmann, Lucas M.; Held, Ulrike; Markwalder, Regula; Thalmann, George N.

2010-01-01

223

Tissue factor-dependent activation of tritium-labeled factor IX and factor X in human plasma  

SciTech Connect

A comparism was made of the tissue factor-dependent activation of tritium-labeled factor IX and factor X in a human plasma system and a study was made of the role of proteases known to stimulate factor VII activity. Plasma was defibrinated by heating and depleted of its factors IX and X by passing it through antibody columns. Addition of human brain thromboplastin, Ca2+, and purified 3H-labeled factor X to the plasma resulted, after a short lag, in burst-like activation of the factor X, measured as the release of radiolabeled activation peptide. The progress of activation was slowed by both heparin and a specific inhibitor of factor Xa but factor X activation could not be completely abolished by such inhibitors. In the case of 3H-factor IX activation, the rate also increased for approximately 3 min after addition of thromboplastin, but was not subsequently curtailed. A survey of proteases implicated as activators of factor VII in other settings showed that both factor Xa and factor IXa could accelerate the activation of factor IX. However, factor Xa was unique in obliterating activation when present at concentrations greater than approximately 1 nM. Heparin inhibited the tissue factor-dependent activation of factor IX almost completely, apparently through the effect of antithrombin on the feedback reactions of factors Xa and IXa on factor VII. These results suggest that a very tight, biphasic control of factor VII activity exists in human plasma, which is modulated mainly by factor Xa. At saturation of factor VIIa/tissue factor, factor IX activation was significantly more rapid than was previously found in bovine plasma under similar conditions. The activation of factor X at saturation was slightly more rapid than in bovine plasma, despite the presence of heparin.

Morrison, S.A.; Jesty, J.

1984-06-01

224

Factor H and neisserial pathogenesis.  

PubMed

Both Neisseria gonorrhoeae and N. meningitidis bind to factor H which enhances their ability to evade complement-dependent killing. While porin is the ligand for human fH on gonococci, meningococci use a lipoprotein called factor H binding protein (fHbp) to bind to factor H and enhance their ability to evade complement-dependent killing. This protein is currently being intensively investigated as a meningococcal vaccine candidate antigen. Consistent with the observation that meningococci cause natural infection only in humans, the organism resists human complement, and are more readily killed by complement from lower animals. This human species-specific complement evasion has important implications for evaluation of vaccine-elicited antibodies using non-human complement sources and development of animal models of disease. PMID:19388163

Welsch, Jo Anne; Ram, Sanjay

2008-12-30

225

Isospectral potentials from modified factorization  

SciTech Connect

Factorization of quantum-mechanical potentials has a long history extending back to the earliest days of the subject. In the present article, the nonuniqueness of the factorization is exploited to derive new isospectral nonsingular potentials. Many one-parameter families of potentials can be generated from known potentials using a factorization that involves superpotentials defined in terms of excited states of a potential. For these cases an operator representation is available. If ladder operators are known for the original potential, then a straightforward procedure exists for defining such operators for its isospectral partners. The generality of the method is illustrated with a number of examples which may have many possible applications in atomic and molecular physics.

Berger, Micheal S.; Ussembayev, Nail S. [Department of Physics, Indiana University, Bloomington, Indiana 47405 (United States)

2010-08-15

226

An unsymmetrized multifrontal LU factorization  

SciTech Connect

A well-known approach to compute the LU factorization of a general unsymmetric matrix bf A is to build the elimination tree associated with the pattern of the symmetric matrix A + A{sup T} and use it as a computational graph to drive the numerical factorization. This approach, although very efficient on a large range of unsymmetric matrices, does not capture the unsymmetric structure of the matrices. We introduce a new algorithm which detects and exploits the structural unsymmetry of the submatrices involved during the process of the elimination tree. We show that with the new algorithm significant gains both in memory and in time to perform the factorization can be obtained.

Amestoy, Patrick R.; Puglisi, Chiara

2000-07-17

227

Environmental risk factors for psychosis  

PubMed Central

Genetic factors are clearly important in the etiology of schizophrenia, but the environment in which an individual's genes find expression is also crucial to the development of the illness. In this review of environmental risk factors for schizophrenia, we consider risks operating prenatally and perinatally, during childhood, and then later in life prior to illness onset. Some of these risk factors have been well documented, for example, early hazards causing fetal growth retardation or hypoxia, and hazards nearer the onset of illness like drug abuse and migration. Others are much less certain. The importance of interaction between genetic and environmental risk is, however, undoubtedly important and there is emerging evidence for this from a range of sources. As the etiology of schiz-ophrenia is unraveled, the picture becomes more complex, but also more obviously relevant to the plight of the individual patient.

Dean, Kimberlie; Murray, Robin M.

2005-01-01

228

Environmental risk factors for psychosis.  

PubMed

Genetic factors are clearly important in the etiology of schizophrenia, but the environment in which an individual's genes find expression is also crucial to the development of the illness. In this review of environmental risk factors for schizophrenia, we consider risks operating prenatally and perinatally, during childhood, and then later in life prior to illness onset Some of these risk factors have been well documented, for example, early hazards causing fetal growth retardation or hypoxia, and hazards nearer the onset of illness like drug abuse and migration. Others are much less certain. The importance of interaction between genetic and environmental risk is, however, undoubtedly important and there is emerging evidence for this from a range of sources. As the etiology of schizophrenia is unraveled, the picture becomes more complex, but also more obviously relevant to the plight of the individual patient. PMID:16060597

Dean, Kimberlie; Murray, Robin M

2005-01-01

229

Environmental risk factors for osteoporosis  

SciTech Connect

Environmental risk factors for osteoporosis were reviewed at a conference held at the National Institute for Environmental Health Sciences 8-9 November 1993. The conference was co-sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease and the NIH Office of Research in Women's Health. The objective of the conference was to review what is known about risk factors for osteoporosis and to identify gaps in the present state of knowledge that might be addressed by future research. The conference was divided into two broad themes. The first session focused on current knowledge regarding etiology, risk factors, and approaches to clinical and laboratory diagnosis. This was followed by three sessions in which various environmental pollutants were discussed. Topics selected for review included environmental agents that interfere with bone and calcium metabolism, such as the toxic metals lead, cadmium, aluminum, and fluoride, natural and antiestrogens, calcium, and vitamin D.

Goyer, R.A.; Korach, K.S. (National Institute of Environmental Health Sciences, Triangle Park, NC (United States)); Epstein, S. (Albert Einstein Medical Center, Philadelphia, PA (United States)); Bhattacharyya, M. (Argonne National Lab., IL (United States)); Pounds, J. (Wayne State Univ., Detroit, MI (United States))

1994-04-01

230

Derived Basic Ability Factors: A Factor Analysis Replication Study.  

ERIC Educational Resources Information Center

|The purpose of this study was to replicate the study conducted by Potter, Sagraves, and McDonald to determine whether their recommended analysis could separate criterion variables into similar factors that were stable from year to year and from school to school. The replication samples consisted of all students attending Louisiana State…

Lee, Mickey, M.; Lee, Lynda Newby

231

Derived Basic Ability Factors: A Factor Analysis Replication Study.  

ERIC Educational Resources Information Center

The purpose of this study was to replicate the study conducted by Potter, Sagraves, and McDonald to determine whether their recommended analysis could separate criterion variables into similar factors that were stable from year to year and from school to school. The replication samples consisted of all students attending Louisiana State University…

Lee, Mickey, M.; Lee, Lynda Newby

232

Factorization and Factorization Breaking in Diffraction at HERA  

SciTech Connect

A recent progress is reviewed in our understanding of diffractive processes at HERA. New precision measurements are now available from both H1 and ZEUS collaborations, from which diffractive parton distribution functions are determined. They are used to test QCD factorization in diffractive production of charm and dijets.

Levonian, S. [DESY, Notkestrasse 85, 22607 Hamburg (Germany)

2006-04-11

233

Inhibition of Hageman factor activation.  

PubMed

A method for studying inhibitors of the contact stages of blood coagulation is described. A number of positively charged substances were shown to inhibit the contact stages. The inhibitory substances include spermine, cytochrome c, ribonuclease, and lysozyme. The inhibitory effect of these substances was neutralized by the addition of an activated plasma thromboplastin antecedent, factor XI, (PTA) fraction. Other positively charged substances including protamine, hexadimethrine, polylysine, polyornithine, methylene blue, and ortho-toluidine blue also inhibited the contact stages of coagulation, but the inhibitory effect on coagulation was not neutralized by the activated PTA fraction. Negatively charged substances such as heparin and insulin did not inhibit the contact stages of coagulation. Cytochrome c inhibited Celite adsorption of a partially purified Hageman factor fraction, and cytochrome, ribonuclease, spermine, and lysozome inhibited the adsorption of Hageman factor from PTA-deficient plasma. Very much smaller quantities of Celite completely adsorbed Hageman factor from the fraction rather than from whole plasma, which suggested the possibility that plasma contains an inhibitor or inhibitors of Hageman factor adsorption. Furthermore cytochrome c, spermine, ribonuclease, and lysozyme inhibited the coagulant activity of the following activators of the Hageman and PTA factors: Celite, kaolin, sodium stearate, ellagic acid, and skin. It is suggested that negatively charged sites on these activators are critical for adsorption and activation and that inhibition results from neutralization of the negatively charged sites by the adsorbed inhibtor. Tests with polylysine polymers indicate that inhibitory activity is directly related to molecular size over the molecular weight range of 4000 to 100,000. PMID:5645860

Nossel, H L; Rubin, H; Drillings, M; Hsieh, R

1968-05-01

234

Factors Associated with Intern Fatigue  

Microsoft Academic Search

BACKGROUND  Prior data suggest that fatigue adversely affects patient safety and resident well-being. ACGME duty hour limitations were\\u000a intended, in part, to reduce resident fatigue, but the factors that affect intern fatigue are unknown.\\u000a \\u000a \\u000a \\u000a OBJECTIVE  To identify factors associated with intern fatigue following implementation of duty hour limitations.\\u000a \\u000a \\u000a \\u000a DESIGN  Cross-sectional confidential survey of validated questions related to fatigue, sleep, and stress, as well

Lindsay D. Friesen; Arpana R. Vidyarthi; Robert B. Baron; Patricia P. Katz

2008-01-01

235

Growth factors in orthopedic surgery.  

PubMed

Growth factors have represented an essential issue of interest for the researchers and clinicians in orthopedics and trauma over the last 40 years. In the last 10 to 15 years, the advances registered in this field have permitted the identification of the most active cellular and humoral factors as well as the improvement of their use in the orthopedic and trauma surgery. Their domain of application has been continuously enlarged and the results have been visible from the beginning. The authors present their appreciation on the actual state of this subject as well as their experience with results and related conclusions. PMID:20302195

Zaharia, Comeliu; Niculescu, Marius; Despa, Nicoleta; Simionescu, Maya; Jinga, Victor; Fleseriu, Irina

236

The Gamma Contamination Food Factor.  

PubMed

We suggest that radioactive food contamination, as determined solely by a quantitative gamma-ray spectroscopic measurement, may, apart from the total activity per unit mass, be for quick reference conveniently characterized by another single figure which we call the "Gamma Contamination Food Factor" (GCFF). This factor may be defined as the ratio of the total specific activity of gamma-ray-emitting radionuclides in the food sample (except that of 40K) to the specific activity of 40K either in the sample itself or in an "average man". We discuss briefly the meaning and advantages of these definitions. PMID:1310305

Kukoc, A H; Anicin, I V; Adzi?, P R

237

Six and Seven as Factors  

NSDL National Science Digital Library

This 2-lesson unit offers a variety of activities and games to help students master multiplication facts with 6 and 7 as factors. It is intended for students who understand the process of multiplication and have mastered the facts where 0, 1, 2, 3, 4, and 5 are factors. Students make use of the effects and properties of multiplication, write and solve story problems, and develop materials and strategies to assist in becoming fluent with the facts. The unit includes questions for students and teachers, a printable multiplication chart, extension ideas, and link to a Virtual Spinner and an online Times Table applet (both catalogued separately).

Burton, Grace M.

2012-01-01

238

Bayes factors and multimodel inference  

USGS Publications Warehouse

Multimodel inference has two main themes: model selection, and model averaging. Model averaging is a means of making inference conditional on a model set, rather than on a selected model, allowing formal recognition of the uncertainty associated with model choice. The Bayesian paradigm provides a natural framework for model averaging, and provides a context for evaluation of the commonly used AIC weights. We review Bayesian multimodel inference, noting the importance of Bayes factors. Noting the sensitivity of Bayes factors to the choice of priors on parameters, we define and propose nonpreferential priors as offering a reasonable standard for objective multimodel inference.

Link, W.A.; Barker, R.J.

2009-01-01

239

The Interaction between Factor H and Von Willebrand Factor.  

PubMed

Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS). A more common TMA is thrombotic thrombocytopenic purpura, which is caused by the lack of normal ADAMTS-13-mediated cleavage of von Willebrand factor (VWF). We investigated whether fH interacts with VWF and affects cleavage of VWF. We found that factor H binds to VWF in plasma, to plasma-purified VWF, and to recombinant A1 and A2 domains of VWF as detected by co-immunoprecipitation (co-IP) and surface plasmon resonance assays. Factor H enhanced ADAMTS-13-mediated cleavage of recombinant VWF-A2 as determined by quantifying the cleavage products using Western-blotting, enhanced cleavage of a commercially available fragment of VWF-A2 (FRETS-VWF73) as determined by fluorometric assay, and enhanced cleavage of ultralarge (UL) VWF under flow conditions as determined by cleavage of VWF-platelet strings attached to histamine stimulated endothelial cells. Using recombinant full-length and truncated fH molecules, we found that the presence of the C-terminal half of fH molecule is important for binding to VWF-A2 and for enhancing cleavage of the A2 domain by ADAMTS-13. We conclude that factor H binds to VWF and may modulate cleavage of VWF by ADAMTS-13. PMID:23991205

Feng, Shuju; Liang, Xiaowen; Cruz, Miguel A; Vu, Hangoc; Zhou, Zhou; Pemmaraju, Naresh; Dong, Jing-Fei; Kroll, Michael H; Afshar-Kharghan, Vahid

2013-08-26

240

Neuroprotection mediated via neurotrophic factors and induction of neurotrophic factors.  

PubMed

Neurotrophins and other neurotrophic factors have been shown to support the survival and differentiation of many neuronal populations of the central and peripheral nervous system. Therefore, administering neurotrophic factors could represent an alternative strategy for the treatment of acute and chronic brain disorders. However, the delivery of neurotrophic factors to the brain is one of the largest obstacles in the development of effective therapy for neurodegenerative disorders, because these proteins are not able to cross the blood-brain barrier. The induction of growth factor synthesis in the brain tissue by systemically administered lipophilic drugs, such as beta-adrenoceptor agonists, shown to increase endogenous nerve growth factor (NGF) synthesis in the brain, would be an elegant way to overcome these problems of application. Stimulation of beta-adrenoceptors with clenbuterol led to increased NGF synthesis in cultured central nervous system (CNS) cells and rat brain tissue. Clenbuterol-induced NGF expression was reduced to the control levels by coadministration of beta-adrenoceptor antagonist propranolol. Furthermore, clenbuterol protected rat hippocampal neurons subjected to excitotoxic damage. The neuroprotective effect of clenbuterol in vitro depended on increased NGF synthesis, since the neuroprotection was abolished by NGF antisense oligonucleotide as well as by antibodies directed against NGF itself. In vivo, clenbuterol protected rat hippocampus in a model of transient forebrain ischemia and reduced the infarct volume in a rat model of permanent middle cerebral artery occlusion (MCAo). The neuroprotective effect of clenbuterol in vivo was accompanied by enhanced NGF synthesis in brain tissue. These findings support our hypothesis that orally active NGF inducers may have a potential as therapeutic agents for the treatment of neurodegenerative disorders and stroke. PMID:10525174

Semkova, I; Krieglstein, J

1999-08-01

241

Software for a New Modified Cholesky Factorization.  

National Technical Information Service (NTIS)

This paper describes the software for a new modified Cholesky factorization recently proposed by the authors. Given a symmetric but not necessarily positive definite matrix A, the modified Cholesky factorization computes a Cholesky factorization of A + E,...

E. Eskow R. B. Schnabel

1989-01-01

242

A Factor Rotation Scheme Giving Orthogonal Bounds  

ERIC Educational Resources Information Center

|A factor rotation scheme is presented which has a property that is interesting for examining factor-structure hypotheses. Given several clusters of tests the orthogonal bounds scheme produces factors which contains these clusters in some optimal sense. (Author)|

Hall, Charles E.

1971-01-01

243

Factor Structure of the Rational Behavior Inventory.  

ERIC Educational Resources Information Center

Administered the Rational Behavior Inventory (RBI) to 510 undergraduates and performed factor analytic procedures. Comparison with the original factors showed nine of the original 11 factor patterns were approximated reasonably. (JAC)

Himle, David P.; And Others

1985-01-01

244

Pollution, Factor Taxation and Unemployment  

Microsoft Academic Search

When consumers choose between clean and dirty goods and the labour market clears, a green tax reform may not bring about a double dividend in the sense of increasing environmental quality and increasing employment. However, when firms choose between clean and dirty factors of production, and when there is unemployment, such a result is very likely to occur. The paper

Erkki Koskela; Ronnie Schöb; Hans-Werner Sinn

1998-01-01

245

2011 Critical Success Factors Report  

ERIC Educational Resources Information Center

The Critical Success Factors Report is the North Carolina Community College System's major accountability document. This annual performance report serves to inform colleges and the public on the performance of North Carolina's 58 community colleges. In 1993, the State Board of Community Colleges began monitoring performance data on specific…

North Carolina Community College System (NJ1), 2011

2011-01-01

246

2012 Critical Success Factors Report  

ERIC Educational Resources Information Center

The Critical Success Factors Report is the North Carolina Community College System's major accountability document. This annual performance report is based on data compiled from the previous year and serves to inform colleges and the public on the performance of North Carolina's 58 community colleges. In 1993, the State Board of Community Colleges…

North Carolina Community College System (NJ1), 2012

2012-01-01

247

Myeloid Colony-Stimulating Factors  

Microsoft Academic Search

acterial and fungal sepsis are major causes of morbidity and mortality in the newborn. Multiple factors contribute to this increased susceptibility to infection, including quan- titative and qualitative neutrophil defects, with a reduction in neutrophil number and function. Neutropenia in the newborn may occur in association with sepsis and has a poor prognosis. In addition to antibiotic therapy and supportive

Horacio Osiovich

1999-01-01

248

Factors Affecting Willingness to Mentor  

ERIC Educational Resources Information Center

|The paper presents a survey among 300 employees in Northern Italy to assess the willingness to mentor and identify the factors that affect it. Men and respondents with previous mentoring experience indicate a higher willingness to be a mentor. Willingness is affected by personal characteristics that are perceived as necessary for a mentor and the…

Ghislieri, Chiara; Gatti, Paola; Quaglino, Gian Piero

2009-01-01

249

Factors influencing solar energy commercialization  

Microsoft Academic Search

The prospects for solar energy commercialization in Arizona are examined. Topics considered include the relative demand potential for selected solar energy products, factors influencing current and future demand for solar energy products, and recommended business and government actions to accelerate commercialization. A Delphi process was used to collect survey data. Water heaters were identified as the solar energy products with

B. J. Walker

1978-01-01

250

Approximate factorization for incompressible flow  

Microsoft Academic Search

For computational solution of the incompressible Navier-Stokes equations, the approximate factorization (AF) algorithm is used to solve the vectorized momentum equation in delta form based on the pressure calculated in the previous time step. The newly calculated velocities are substituted into the pressure equation (obtained from a linear combination of the continuity and momentum equation), which is then solved by

R. S. Bernard

1981-01-01

251

Interpersonal factors in premarital contraception  

Microsoft Academic Search

We reviewed 52 studies published since 1970 investigating interpersonal factors related to the contraceptive behavior of unmarried adolescents and young adults. The studies focused largely on white, middle?class women from student and clinic populations. Methodological problems included poorly defined samples and procedures, a relative lack of random sampling techniques, and a heavy reliance on subjects' self?reports. Methodological strengths included generally

Richard J. Milan Jr; Peter R. Kilmann

1987-01-01

252

Cognitive Factors in Academic Achievement.  

ERIC Educational Resources Information Center

|This review explores the factors of cognitive processing, style, and metacognitive organization as they contribute to academic success. Specific discussions consider aspects of short- and long-term memory, including how these affect learning and academic performance, and the keys to attaining long-term memory capability by involving redundancy,…

Cuasay, Peter

1992-01-01

253

GENETIC EFFECTS OF SPACEFLIGHT FACTORS  

Microsoft Academic Search

With the object of investigating effects of spaceflight factors on ; heredity, Drosophila melanogaster was carried on the second, fourth, and fifth ; orbital spaceships and on Vostok-1 and Vostok-2. Four different spaceflight ; effects were investigated. Nondisjunction of chromosomes was investigated by ; exposing unfertilized white-eyed Drosophila females on Vostoks 1 and 2 and mating ; them on their

Ya. L. Glembotskii; G. P. Parfenov

1962-01-01

254

Factors Influencing College Science Success  

ERIC Educational Resources Information Center

|In this paper, the authors report some of the salient findings of a large-scale, four-year national study, conducted at the Harvard-Smithsonian Center for Astrophysics, entitled "Factors Influencing College Science Success" (FICSS), which surveyed college students who enrolled in first-year biology, chemistry, and physics courses throughout the…

Tai, Robert H.; Sadler, Philip M.; Mintzes, Joel J.

2006-01-01

255

Time dependent view factor methods  

SciTech Connect

View factors have been used for treating radiation transport between opaque surfaces bounding a transparent medium for several decades. However, in recent years they have been applied to problems involving intense bursts of radiation in enclosed volumes such as in the laser fusion hohlraums. In these problems, several aspects require treatment of time dependence.

Kirkpatrick, R.C.

1998-03-01

256

Nonnegative matrix factorization with ?-divergence  

Microsoft Academic Search

Nonnegative matrix factorization (NMF) is a popular technique for pattern recogni- tion, data analysis, and dimensionality reduction, the goal of which is to decompose nonnegative data matrix X into a product of basis matrix A and encoding variable matrix S with both A and S allowed to have only nonnegative elements. In this paper we consider Amari's ?-divergence as a

Andrzej Cichocki; Hyekyoung Lee; Yong-Deok Kim; Seungjin Choi

2006-01-01

257

Factors Affecting Onset of Puberty  

Microsoft Academic Search

In humans, foetal and early postnatal growth failure may have persistent consequences for growth and pubertal development in later life. During this period, the developing organs are still plastic to change their function, which may have long-lasting effects. At the time of onset of puberty, acute factors may also interfere with pubertal development. Malnutrition, as seen in anorexic patients, and

Henriette A. Delemarre-van de Waal; Silvia C. C. M. van Coeverden; Mia J. T. Engelbregt

2002-01-01

258

New Photon Exposure Buildup Factors  

SciTech Connect

A New Monte Carlo code (EBUF) is developed to calculate improved point isotropic photon exposure buildup factors in media. Variance reduction techniques are used to perform calculations up to 60 mean free paths. EBUF accounts for coherent scattering and bound-electron Compton scattering. Bremsstrahlung photons and annihilation gamma rays as well as K and L X-rays are considered. The most recent cross-section data are used. The EBUF exposure buildup factors compare very well with those from the ANS-6.4.3 Working Group (ANS-6.4.3) when the same initial conditions are assumed: no coherent scattering, free-electron Compton scattering, and only K X-ray fluorescence. Next, a detailed physics treatment is used to calculate a representative set of exposure buildup factors in aluminum, iron, lead, water, air, and concrete over a large energy range (20 keV to 10 MeV). The effects of L X-rays are shown for lead at low energy. The EBUF factors are in good agreement with the SN1D code results for low-Z media. Finally, total exposure values from EBUF and ANS-6.4.3 are compared. Quite significant differences are observed because the ANS-6.4.3 calculations do not account for binding effects in Compton scattering, L X-ray fluorescence, and coherent scattering in mixtures.

Chibani, Omar

2001-02-15

259

Impact factors in nursing journals  

Microsoft Academic Search

Journal impact factors (IFs), a measure of citation frequency, are published annually in Journal Citation Reports (JCR). Journal IFs, although controversial because of the uses to which they have been put in academic arenas, remain a metric about which nurses should be informed. This paper discusses key issues in the controversy, explains how IFs are computed, and presents historical and

Denise F. Polit; Sally Northam

2011-01-01

260

Three Phase Power Factor Controller.  

National Technical Information Service (NTIS)

A power control circuit for a three phase induction motor is described. The power factors for the three phases are summed to provide a control signal. This control signal is particularly filtered and then employed to control the duty cycle of each phase o...

F. J. Nola

1980-01-01

261

Human Factors in Visualization Research  

Microsoft Academic Search

Abstract - Visualization can provide valuable assistance for data analysis and decision making tasks and interact with a visualization tool can strongly influence their understanding of the data as well as the system's usefulness factors therefore contribute significantly to the visualization process and should play an important role in the design and evaluation of visualization tools Several research initiatives have

Melanie Tory; Torsten Möller

2004-01-01

262

Growth factors in haematological cancers.  

PubMed

Since their discovery just under a century ago, growth factors (GFs) have been used almost ubiquitously in haematology. Many haematological cancers are associated with bone marrow failure, either as a direct consequence of the disease or its treatment. Colony stimulating factors (CSFs) have been used to address the problems associated with the resulting cytopenias, however, concerns about the potential leukaemogenic effects of some of these CSFs led to a degree of initial hesitancy in usage, particularly in the management of acute myeloid leukaemia (AML). This has now been largely overcome. Other limitations have included cost and side effect profiles (the latter particularly with the multilineage factors). There has been wide variation locally, nationally and internationally in the usage of GFs. The American Society of Clinical Oncologists (ASCO) attempted to rationalise the usage of GFs by producing a consensus document enumerating the evidence-based indications for use of GFs. There is little information on cost effectiveness, this remains an important issue for the future. Peripheral blood stem cell transplantation (PBSCT) has revolutionised the management of many malignant conditions and has contributed to the increased use of growth factors. Many other indications are emerging for GFs used singly or in combination. Current clinical applications of GFs include: i) amelioration of cytopenias following chemotherapy and stem cell transplantation, ii) chemotherapy dose maintenance and escalation, iii) chemosensitisation and modification of disease states, iv) optimisation of methods for mobilisation of progenitor stem cells, v) immunotherapy, and vi) as therapeutic targets for treatment of haematolgical malignancies. PMID:15989543

Osuji, Nnenna; Pettengell, R

2002-05-01

263

Virulence factors of Candida species  

Microsoft Academic Search

Candida albicans is an opportunistic human pathogen, which colonizes at several anatomically distinct sites including skin, oral, gastrointestinal tract, and vagina. How harmless commensal C. albicans become a human pathogen when opportunity comes is not clear. This review will focus on the molecular dissection of virulence factors of C. albicans, including adhesion, proteinases secretion, hyphal formation, and phenotypic switching. This

Yun-Liang Yang

264

Family Factors and Student Outcomes  

ERIC Educational Resources Information Center

|There is considerable debate about the relative importance of family versus school factors in producing academic and nonacademic student outcomes, and whether and how their impacts vary across different student groups. In addition to critically reviewing and synthesizing earlier work, this study extends the literature by (a) using the ECLS-K, a…

Xia, Nailing

2009-01-01

265

Factors governing tropospheric mean temperature.  

PubMed

Two possible factors, which in addition to Pacific sea surface temperatures might affect the mean temperatures of the tropical troposphere are Atlantic sea surface temperatures and volcanic aerosol. The Mt. Agung eruption in March 1963 produced a decrease of about 0.5 degrees C in the mean temperature of the tropical troposphere. The contribution of the Atlantic is not significant. PMID:17819278

Newell, R E; Weare, B C

1976-12-24

266

Factors Affecting Willingness to Mentor  

ERIC Educational Resources Information Center

The paper presents a survey among 300 employees in Northern Italy to assess the willingness to mentor and identify the factors that affect it. Men and respondents with previous mentoring experience indicate a higher willingness to be a mentor. Willingness is affected by personal characteristics that are perceived as necessary for a mentor and the…

Ghislieri, Chiara; Gatti, Paola; Quaglino, Gian Piero

2009-01-01

267

An introduction to factor graphs  

Microsoft Academic Search

Graphical models such as factor graphs allow a unified approach to a number of key topics in coding and signal processing such as the iterative decoding of turbo codes, LDPC codes and similar codes, joint decoding, equalization, parameter estimation, hidden-Markov models, Kalman filtering, and recursive least squares. Graphical models can represent complex real-world systems, and such representations help to derive

Hans-Andrea Loeliger; ETH Zurich

2004-01-01

268

Transforming Rubrics Using Factor Analysis  

ERIC Educational Resources Information Center

Student learning and program effectiveness is often assessed using rubrics. While much time and effort may go into their creation, it is equally important to assess how effective and efficient the rubrics actually are in terms of measuring competencies over a number of criteria. This study demonstrates the use of common factor analysis to identify…

Baryla, Ed; Shelley, Gary; Trainor, William

2012-01-01

269

Employability Development Teams: Cohesion Factors  

ERIC Educational Resources Information Center

In this study the researchers attempted to analyze the factors of age, sex, racial-ethnic background, operational life of the team, educational status, leader status, team size, caseload size, and the location of program site in terms of their potential effects upon team cohesion. (Author)

Johnson, Douglas W.; Munger, Paul F.

1972-01-01

270

Psychological Factors and Distance Education.  

ERIC Educational Resources Information Center

Describes various models of learning styles and speculates on their applicability to distance education practice and research. Topic discussed include field dependence and independence; the Kolb Model; hemisphericity; sensory preferences; the Jungian approach; Myers Briggs Type Indicator (MBTI); and psychological factors including age, sex…

Ehrman, Madeline

1990-01-01

271

Factors Influencing College Science Success  

ERIC Educational Resources Information Center

In this paper, the authors report some of the salient findings of a large-scale, four-year national study, conducted at the Harvard-Smithsonian Center for Astrophysics, entitled "Factors Influencing College Science Success" (FICSS), which surveyed college students who enrolled in first-year biology, chemistry, and physics courses throughout the…

Tai, Robert H.; Sadler, Philip M.; Mintzes, Joel J.

2006-01-01

272

Multiple Risk Factor Intervention Trial.  

National Technical Information Service (NTIS)

The Multiple Risk Factor Intervention Trial is a primary prevention trial to determine the extent to which mortality from coronary heart disease may be reduced by the reduction of blood cholesterol, blood pressure and cigarette smoking in high risk men ag...

1975-01-01

273

Multiple Risk Factor Intervention Trial.  

National Technical Information Service (NTIS)

The Multiple Risk Factor Intervention Trial is a primary prevention trial to determine the extent to which mortality from coronary heart disease may be reduced by the reduction of blood cholesterol, blood pressure and cigarette smoking in high risk men ag...

1976-01-01

274

Critical factors to bioenergy implementation  

Microsoft Academic Search

Barriers to bioenergy technology implementation have received increased attention in recent years. This paper contributes to the identification and analysis of barriers and drivers behind bioenergy market growth, here labelled “critical factors”. It presents a framework for the analysis of both existing and projected bioenergy market potential, using economic concepts and models from transaction cost theory and industrial organization. The

Anders Roos; Robin L. Graham; Bo Hektor; Christian Rakos

1999-01-01

275

Dietary factors, hormesis and health.  

PubMed

The impact of dietary factors on health and longevity is increasingly appreciated. The most prominent dietary factor that affects the risk of many different chronic diseases is energy intake -- excessive calorie intake increases the risk. Reducing energy intake by controlled caloric restriction or intermittent fasting increases lifespan and protects various tissues against disease, in part, by hormesis mechanisms that increase cellular stress resistance. Some specific dietary components may also exert health benefits by inducing adaptive cellular stress responses. Indeed, recent findings suggest that several heavily studied phytochemicals exhibit biphasic dose responses on cells with low doses activating signaling pathways that result in increased expression of genes encoding cytoprotective proteins including antioxidant enzymes, protein chaperones, growth factors and mitochondrial proteins. Examples include: activation of the Nrf-2 -- ARE pathway by sulforaphane and curcumin; activation of TRP ion channels by allicin and capsaicin; and activation of sirtuin-1 by resveratrol. Research that establishes dose response and kinetic characteristics of the effects of dietary factors on cells, animals and humans will lead to a better understanding of hormesis and to improvements in dietary interventions for disease prevention and treatment. PMID:17913594

Mattson, Mark P

2007-09-01

276

Psychosocial factors and ballet injuries  

Microsoft Academic Search

The purpose of this study was to investigate whether psychosocial factors, such as stress, anxiety, social support, and coping skills, could predict injuries (frequency and duration) among 105 ballet dancers (101 females; 4 males). The dancers were professional ballet dancers (n = 27), university ballet students (n = 19), and ballet institute students (n = 59), with a mean age

Tony Morris; Mark B. Andersen

2005-01-01

277

[Risk factors in periodontal disease].  

PubMed

Some life styles and systemic pathologies represent risk factors for the periodontal disease. Cigarette smoking in particular increases the speed of progression of periodontitis. Other conditions such as diabetes mellitus, presence of genetic markers and some bacteria are significantly correlated with the periodontal disease. PMID:12660616

Sartori, S; Silvestri, M

2002-12-01

278

Factors Influencing Household Recycling Behavior  

Microsoft Academic Search

To investigate factors encouraging or deterring recycling, telephone interviews were used to study recycling behavior, attitudes, and knowledge of 221 randomly selected adults in a suburban city that had begun a citywide curbside recycling program within the past year. Approximately 40% reported participation in the curbside recycling program, and nearly 20% more claimed that their household had been recycling in

Stuart Oskamp; Maura J. Harrington; Todd C. Edwards; Deborah L. Sherwood; Shawn M. Okuda; Deborah C. Swanson

1991-01-01

279

Risk factors for postoperative ileus  

PubMed Central

Purpose This study aimed to examine extended postoperative ileus and its risk factors in patients who have undergone abdominal surgery, and discuss the techniques of prevention and management thereof the light of related risk factors connected with our study. Methods This prospective study involved 103 patients who had undergone abdominal surgery. The effects of age, gender, diagnosis, surgical operation conducted, excessive small intestine manipulation, opioid analgesic usage time, and systemic inflammation on the time required for the restoration of intestinal motility were investigated. The parameters were investigated prospectively. Results Regarding the factors that affected the restoration of gastrointestinal motility, resection operation type, longer operation period, longer opioid analgesics use period, longer nasogastric catheter use period, and the presence of systemic inflammation were shown to retard bowel motility for 3 days or more. Conclusion Our study confirmed that unnecessary analgesics use in patients with pain tolerance with non-steroid anti-inflammatory drugs, excessive small bowel manipulation, prolonged nasogastric catheter use have a direct negative effect on gastrointestinal motility. Considering that an exact treatment for postoperative ileus has not yet been established, and in light of the risk factors mentioned above, we regard that prevention of postoperative ileus is the most effective way of coping with intestinal dysmotility.

Kutun, Suat; Ulucanlar, Haluk; Tarcan, Oguz; Demir, Abdullah; Cetin, Abdullah

2011-01-01

280

Atomic polarizabilities and shielding factors  

Microsoft Academic Search

A detailed discussion is given of the methods of calculating atomic polarizabilities and shielding factors and the relationships between them are demonstrated. The formulation of the uncoupled Hartree-Fock approximation is presented and it is shown that the methods are all approximate versions of it. A more accurate procedure, the coupled Hartree-Fock approximation, is described. Comprehensive tables of dipole and quadrupole

A. Dalgarno

1962-01-01

281

Factor analysis in environmental studies  

Microsoft Academic Search

In our days, factor analysis has become an important statistical instrument of investigation in modern science, being an adequate tool to investigate the principles of interaction of components and their in- tegration into a system. The paper, not pretending to a complete and detailed review, is intended mainly for a wide community of ecologists, which are interesting in principles of

Alexander S. Kaplunovsky

282

Guidelines, evidence, and cultural factors  

Microsoft Academic Search

OBJECTIVE: To compare four recent guidelines on uncomplicated cystitis and to examine how cultural factors may have affected recommendations. DESIGN: Descriptive study with a qualitative analysis of authors' reasons for recommendations. MATERIAL: Guidelines for general practitioners published 1999-2000 from Germany, The Netherlands, Norway, and Belgium on diagnosis and treatment of uncomplicated cystitis. Opinions of the guideline authors on the influence

T. Christiaens; D. de Backer; J. S. Burgers; A. Baerheim

2004-01-01

283

Factors of style and personality  

Microsoft Academic Search

In an attempt to find relationships between psychological and linguistic variables, style samples of short stories, 300 words each, were analyzed according to formal criteria and the results were correlated with scores on personality tests. The number of significant correlations supported the hypothesis that style is related to personality. A factor analysis, using the principal component solution and Varimax rotation

Ernst Moerk

1972-01-01

284

Solving Quadratic Equations by Factoring  

NSDL National Science Digital Library

This video explains how to solve quadratic equations with the factoring method. In 4 minutes 23 seconds, the two narrators explain in detail the steps required. Additionally, how these equations relate to objects and events in the real world such as roller coasters is covered.

2012-08-06

285

Relaxin: an endogenous renoprotective factor?  

PubMed

Fibrosis, so-called scarring, is a key cause of pathology and dysfunction in a variety of organs. The biology of healing and scarring are similar, albeit with very different outcomes. Typical of this process in general, renal fibrosis is the result of a disproportionate accumulation of extracellular matrix that occurs in ongoing kidney disease. Renal scarring is both progressive and multifactorial, ultimately leading to end-stage renal failure and the requirement for dialysis or kidney transplantation. Regardless of the underlying etiology, renal mesenchymal cells such as fibroblasts are the cellular basis of this process. Activity and differentiation of these cells are regulated by a number of profibrotic cytokines, growth factors, vasoactive mediators, and other signals, with transforming growth factor-beta being among the most important. However, we now also recognize that there are a number of endogenous antifibrotic factors that are renoprotective by counteracting these signals to limit matrix synthesis and organization and reduce net accumulation. Relaxin is one such factor. The absence of endogenous relaxin results in spontaneous fibrosis with aging and also accelerates the pathogenesis of progressive fibrosis after injury. Both effects are reversed by replenishment with recombinant H2 relaxin. This review summarizes recent developments in the understanding of the cellular and molecular mechanisms in fibrosis and how these are influenced by relaxin. PMID:19416206

Hewitson, Tim D; Samuel, Chrishan S

2009-04-01

286

Family Factors and Student Outcomes  

ERIC Educational Resources Information Center

There is considerable debate about the relative importance of family versus school factors in producing academic and nonacademic student outcomes, and whether and how their impacts vary across different student groups. In addition to critically reviewing and synthesizing earlier work, this study extends the literature by (a) using the ECLS-K, a…

Xia, Nailing

2009-01-01

287

Benchmark Factors in Student Retention.  

ERIC Educational Resources Information Center

The first purpose of this study was to identify significant factors affecting the first benchmark in retaining students in college--the decision to enroll in the first fall semester after orientation. The second purpose was to examine enrollment decisions at the second benchmark--the decision to re-enroll in the second fall semester after freshman…

Waggener, Anna T.; Smith, Constance K.

288

Efficient networks for quantum factoring  

NASA Astrophysics Data System (ADS)

We consider how to optimize memory use and computation time in operating a quantum computer. In particular, we estimate the number of memory quantum bits (qubits) and the number of operations required to perform factorization, using the algorithm suggested by Shor [in Proceedings of the 35th Annual Symposium on Foundations of Computer Science, edited by S. Goldwasser (IEEE Computer Society, Los Alamitos, CA, 1994), p. 124]. A K-bit number can be factored in time of order K3 using a machine capable of storing 5K+1 qubits. Evaluation of the modular exponential function (the bottleneck of Shor's algorithm) could be achieved with about 72K3 elementary quantum gates; implementation using a linear ion trap would require about 396K3 laser pulses. A proof-of-principle demonstration of quantum factoring (factorization of 15) could be performed with only 6 trapped ions and 38 laser pulses. Though the ion trap may never be a useful computer, it will be a powerful device for exploring experimentally the properties of entangled quantum states.

Beckman, David; Chari, Amalavoyal N.; Devabhaktuni, Srikrishna; Preskill, John

1996-08-01

289

Quantum Computers, Factoring and Decoherence  

Microsoft Academic Search

In a quantum computer any superposition of inputs evolves unitarily into the correspond- ing superposition of outputs. It has been recently demonstrated that such computers can dramatically speed up the task of finding factors of large numbers - a problem of great practical significance because of its cryptographic applications. Instead of the nearly ex- ponential (? exp L1\\/3, for a

I. L. Chuang; R. Laflamme; P. Shor; W. H. Zurek

1995-01-01

290

Prognostic factors for peritonitis outcome.  

PubMed

Despite advances in treatment and prevention, peritonitis remains a major problem in peritoneal dialysis (PD) patients with often technique failure as a consequence. The last decades the focus of PD peritonitis has changed from lowering peritonitis incidence to improvement of peritonitis outcome. Prognostic factors for peritonitis outcome can influence decision making during the treatment of peritonitis, for example to take out the PD catheter early in the time course of peritonitis and prevent further damage to the peritoneal membrane. In this paper, we give a review of the literature about prognostic factors for peritonitis outcome. In most studies, age, gender, diabetes, time on PD, a precursor of calcitonin:procalcitonin, IL-6 and albumin did not show a significant effect on peritonitis outcome. The following factors have been associated with poor outcome of peritonitis: Gram-negative organisms, Mycobacterium species, fungal peritonitis, polymicrobial peritonitis, concurrent exit site or tunnel infection, Caucasian race, low residual GFR, persistently elevated peritoneal dialysate white cell count, CRP, and low levels of slCAM-1 and hyaluronan at the end of peritonitis treatment. In fungal peritonitis, abdominal pain, bowel obstruction, the catheter remaining in situ and Candidaparapsilosis are factors associated with higher mortality rate and a greater risk of technique failure. Recent antibiotic therapy and peritonitis are associated with poor treatment response in culture-negative peritonitis. Recurrent peritonitis episodes have a poor therapeutic response and high mortality and have a worse prognosis than relapsing ones. Older age, long PD duration and continuous elevated serum CRP levels are predictors of adverse outcomes in PD patients after peritonitis-related catheter removal. Peritonitis remains a serious complication of PD with marked morbidity. It is a common cause of technique failure. The rate of PD-related peritonitis has decreased over the last decades due to advances in treatment and prevention. Nowadays, the focus moved from lowering peritonitis incidence towards improving peritonitis outcome. It is useful to have prognostic factors for peritonitis outcome, because they can influence decision-making during the treatment of peritonitis, for example to take out the PD catheter early in the time course of peritonitis and prevent further damage to the peritoneal membrane. In the last decades, many publications appeared about prognostic factors for peritonitis outcome. This article summarizes those prognostic factors, based on an extensive review of the literature. PMID:22652748

van Esch, Sadie; Krediet, Raymond T; Struijk, Dirk G

2012-05-25

291

Prognostic Factors in Myelodysplastic Syndromes  

PubMed Central

ABSTRACT Background: Myelodysplastic syndromes (MDS) are clonal disorders of hematopoietic stem cell and are characterized by ineffective hematopoiesis with normo- or hyper cellular bone marrow and cytopenia(s).The natural evolution of the disease consists of bone marrow failure (leading to infectious and hemorrhagic episodes or anemia related complications) and transformation to acute myeloid leukemia. Because MDSs display remarkable clinical, pathologic, and cytogenetic heterogeneity, with variable evolution and survival ranging from months to years, the predictive factors of prognosis have a key role in optimal therapeutic decisions. The purpose of this paper is to analyze prognostic factors within a group of patients diagnosed with myelodysplastic syndromes. The prognostic factors taken into account are: the number and depth of cytopenias, percentage of bone marrow blasts, cytogenetic abnormalities, intensity of anemia and transfusional dependence. These factors are related to overall survival, leukemia free survival, bone marrow failure complications, leukemic evolution, treatment decisions and the response to treatment. Material and method: The study group comprises of 119 patients diagnosed with de novo MDS, between 2008 and 2011 in the Hematology Department of Coltea Clinical Hospital. In this monitoring period the patients were stratified according to the FAB (French-American-British) morphologic classification. Results: This study revealed that the outcomes of patients with MDS is influenced by the percentage of bone marrow blasts at diagnosis, the number and severity of hematopoietic lineage affected by cytopenia and by the presence of chromosomal abnormalities. Conclusions: The studied prognostic factors have predictive value in terms of survival, leukemic transformation, treatment response and development of bone marrow failure-related characteristic complications.

TRIANTAFYLLIDIS, Irina; CIOBANU, Anca; STANCA, Oana; LUPU, Anca Roxana

2012-01-01

292

Recall: Antihemophilic Factor, Human - CSL Behring LLC  

Center for Biologics Evaluation and Research (CBER)

... Recall: Antihemophilic Factor, Human - CSL Behring LLC. ... Monoclate- P®, 1000 Unit Vials Antihemophilic Factor, Human. ... More results from www.fda.gov/biologicsbloodvaccines/safetyavailability/recalls

293

Psychological factors and coronary heart disease  

PubMed Central

BACKGROUND Although psychological factors play an important role in coronary heart diseases (CHD), it seems there is a need for more researches in this respect. The present study aimed to review psychological factors, including depression, anxiety and stress related to etiology and prognosis of CHD. METHODS This was a review on medical and psychological literatures, particularly in the years 1995-2012. RESULTS As protective factor or risk factor, psychological factors play an important role in CHD. CONCLUSION Given the findings of this study, it seems necessary that we pay attention to psychological factors, as independent risk factors or protective factors for CHD.

Khayyam-Nekouei, Zohreh; Neshatdoost, Hamidtaher; Yousefy, Alireza; Sadeghi, Masoumeh; Manshaee, Gholamreza

2013-01-01

294

Predictors of Multitasking with Media: Media Factors and Audience Factors  

Microsoft Academic Search

In this research, multitasking with media is defined as an audience behavior that combines media use with another non-media activity. This study examines (a) the prevalence and patterns of multitasking among 14- to 16-year-olds and (b) the media and audience factors that predict such behavior. Consistent with previous research, this study found that youth frequently multitask with media. Both (a)

Se-Hoon Jeong; Martin Fishbein

2007-01-01

295

[Preeclampsia as cardiovascular risk factor].  

PubMed

Cardiovascular diseases (CVD) are the primary cause of death in women. Guidelines for identifying high-risk individuals have been developed, e.g. the Dutch Guideline on Cardiovascular Risk Management. In the most recent version of this guideline, diabetes mellitus (DM) and rheumatoid arthritis (RA) are cited as cardiovascular risk factors; therefore, individuals with these conditions are identified as being at high risk. As with DM and RA, there is strong evidence that the experience of having a hypertensive disorder during pregnancy is a cardiovascular risk factor. This is particularly the case for early preeclampsia, which constitutes a 7-fold increased risk of ischemic heart disease. However, in the Netherlands, there are no guidelines and there is no consensus on how to screen or treat these women. Trial evidence is therefore urgently needed to substantiate the value of cardiovascular risk management for those women with a history of hypertension during pregnancy. PMID:23965245

Heida, K Y; Franx, A; Bots, M L

2013-01-01

296

[Prognostic factors in breast cancer].  

PubMed

Prognostic factors are clinical and pathological features that give information in estimating the likely clinical outcome of an individual suffering from cancer. The author gives a short review of the most important prognostic factors in breast cancer. 376 breast cancer cases of a ten year interval in a county hospital are summarized. Traditional clinico-pathological parameters i.e. TNM and steroid receptor status are discussed. The more common karyotipic, oncogene and tumor suppressor gene alterations are outlined in the study. Methods for their detection are presented and their value in prognostication is reviewed. Emphasis was laid on steroid receptors, c-erpB-2, p53 and bcl-2 alterations. Genes responsible for heritable forms of increased breast cancer risk are briefly reviewed. PMID:9608769

Vajda, K

1998-05-01

297

Risk factors for venous thromboembolism.  

PubMed

Risk factors for venous thromboembolism (VTE) are often modifiable and overlap with risk factors for coronary artery disease. Encouraging our patients to adopt a heart-healthy lifestyle by abstaining from cigarettes, maintaining lean weight, limiting red meat intake, and controlling hypertension might lower the risk of pulmonary embolism and deep vein thrombosis (DVT), although a cause-effect relationship has not been firmly established. For hospitalized patients, guidelines have provided evidence-based strategies to identify patients at risk, such as elderly persons and those with cancer, congestive heart failure, or chronic obstructive pulmonary disease or undergoing major surgery. Most should receive pharmacological prophylaxis, which will minimize the risk of VTE. Because approximately 3 of every 4 pulmonary embolism and DVT events occur outside the hospital setting, patients should also be assessed for persistent high-risk of VTE at the time of hospital discharge. PMID:20620709

Goldhaber, Samuel Z

2010-06-29

298

The classical atomic form factor  

NASA Astrophysics Data System (ADS)

The general trends exhibited in the variation of the inelastic form factor in collisional transitions nl arrow n^' l^', when l^' is changed and n,l and n^' are kept fixed are explained solely in terms of classical mechanics. The previous quantum mechanical results(M.R.Flannery and K.J.McCann, J.Phys.B, 12), 427 (1979); Astrophys.Journ., 236, 300 (1980) are reproduced from purely classical-mechanics principles. Our conclusions are valid not only for large quantum numbers (which provide the usual classical limit) but also for other cases, which, up to now have only been described by quantal or semi-quantal methods.footnotemark[2] The interesting trends exhibited in the form factor are directly reflected in theoretical treatments of collisions involving excited atoms.

Vrinceanu, D.; Flannery, M. R.

1997-04-01

299

[Plant Trihelix transcription factors family].  

PubMed

The Trihelix transcription factor family has raised great concerns only in recent years. It was named after its conserved DNA binding domain containing three tandem helix (helix-loop-helix-loop-helix), which could bind specifically with GT element, a light-responsive DNA element. So, this family is also known as GT factors. At the early stage of study, the knowledge of this family was only confined to their functions in regulation of light-responsive genes. However, recent researches indicated that Trihelix family also plays important roles in different growth and development processes involving flowers, stomata, trichomes, embryos, and seeds, as well as roles in response to abiotic and biotic stresses. This review mainly focused on the structural characteristics, classification, and the latest functional research progresses on the Trihelix family. PMID:23262102

Luo, Jun-Ling; Zhao, Na; Lu, Chang-Ming

2012-12-01

300

Molecular factors stabilizing protein crystals  

NASA Astrophysics Data System (ADS)

Crystal properties of two proteins, cytochrome c? and hen egg-white lysozyme, are described in a context emphasizing characteristics of molecular structure important in lattice formation and stability. Major factors involved in lattice formation include protein conformational flexibility and incorporation of structured solvent at crystal contacts. Although protein surfaces provide multiple bonding sites, different crystal forms of lysozyme incorporate similar molecular chains. Molecular chain formation in proteins may be related both to crystal nucleation and development of macroscopic crystal habit.

Salemme, F. R.; Genieser, Lars; Finzel, B. C.; Hilmer, R. M.; Wendoloski, J. J.

1988-07-01

301

Factors Influencing Wind Energy Curtailment  

Microsoft Academic Search

Nonphysically firm wind generation connections (i.e., those to which curtailment can apply) may be necessary for signifi- cant wind integration to congested transmission networks. A study of factors influencing this associated wind energy curtailment is, therefore,oftimelyimportance.Inthispaper,thewindcurtailment estimation effects of natural inter-yearly wind profile variability, systemdemand-profile\\/fuel-priceparameteruncertainty,andmin- imum system inertial constraints are studied in detail. Results in- dicate that curtailment estimation error

Daniel J. Burke; Mark J. O'Malley

2011-01-01

302

Performance factors in ski jumping  

Microsoft Academic Search

Predominant performance factors in ski jumping are: High in-run velocity, high linear momentum perpendicular to the ramp at\\u000a take-off due to the jumping movement and the utilisation of aerodynamic lift, accurate timing of the take-off jump with respect\\u000a to the edge of the ramp, appropriate angular momentum at take-off in order to obtain an aerodynamically advantageous and stable\\u000a flight position

Wolfram Müller

303

Pharmacologic Factors Affecting Glycemic Control  

Microsoft Academic Search

Among many challenges to achieving and maintaining glycemic control, the impact of pharmacologic agents on glycemia is a significant,\\u000a but often overlooked factor. Numerous medications have been implicated in the development of drug-induced hyperglycemia and\\u000a type 2 diabetes mellitus. Of these, the atypical antipsychotics (for the management of depression and psychosis), the protease-inhibitor\\u000a anti retroviral agents (for the management of

Lillian F. Lien

304

Prognostic factors in methanol poisoning  

Microsoft Academic Search

The aim of this study was to assess the clinical and laboratory factors in methanol poisoned patients to determine the prognosis of their toxicity. This survey was done as a prospective cross-sectional study in methanol-poisoned patients in Loghman-Hakim hospital poison center during 9 months from October 1999—June 2000. During this time 25 methanol-poisoned patients were admitted. The mortality rate was

H. Hassanian-Moghaddam; A. Pajoumand; S. M. Dadgar; Sh. Shadnia

2007-01-01

305

Microglia-derived cytotoxic factors  

Microsoft Academic Search

The rarity of neoplasms in the adult mammalian retina has led us to hypothesize the presence or increased expression of `tumor-inhibitory molecules' in the mature differentiated retina. We have begun to investigate the source(s) of these molecules, and the following study describes the inhibitory activity of a soluble microglia-derived cytotoxic factor on the proliferation of C6 cells, a glial tumor

Armando A Rosales; Rouel S Roque

1997-01-01

306

Urinary Mutagens and Lifestyle Factors  

Microsoft Academic Search

Background.Lifestyle determines the amount of exposure to environmental carcinogens\\/mutagens. We examined the relationship between various lifestyle factors and the urinary level of mutagens, which reflects both exposure dose and metabolism of these carcinogens\\/mutagens.Methods.Twenty-four-hour urine specimens obtained from 69 males were subjected to blue rayon extraction, after which the elutions were fractionated by carboxymethyl cellulose column chromatography. The mutagens were measured

Kanae Mure; Tatsuya Takeshita; Toru Takeuchi; Kanehisa Morimoto

1996-01-01

307

Azoospermia factor and male infertility  

Microsoft Academic Search

Recently, work has shown that azoospermia factor (AZF) microdeletions result from homologous recombination between almost\\u000a identical blocks in this gene region. These microdeletions in the Y chromosome are a common molecular genetic cause of spermatogenetic\\u000a failure leading to male infertility. After completion of the sequencing of the Y chromosome, the classical definition of AZFa,\\u000a AZFb, and AZFc was modified to

Eitetsu Koh; Ho-Su Sin; Masato Fukushima; Mikio Namiki

2010-01-01

308

Background factors in anorexia nervosa  

Microsoft Academic Search

Fifty-one adolescents with anorexia nervosa and 51 sex-, age- and school-matched comparison cases were psychiatrically and physically examined. Twenty-four of the anorexia cases constituted the total population of anorexia nervosa cases born in 1970. The cases were examined at a mean age of 16 years. The mothers were interviewed in detail concerning hereditary and other family factors, child's early physical

Maria Råstam; Christopher Gillberg

1992-01-01

309

Impact fact-or fiction?  

PubMed

The Journal Impact Factor dominates research assessment in many disciplines and in many countries. While research assessment will always have to rely to some extent on quantitative, standardized metrics, the focus on this single measure has gone so far as to hamper and distort scientific research. The Declaration on Research Assessment (DORA), signed by influential journals, funders, academic institutions and individuals across the natural sciences, aims to raise awareness and to redress the use of non-objective research assessment practices. PMID:23685358

Pulverer, Bernd

2013-05-17

310

Head injuries, factors associated, outcomes  

Microsoft Academic Search

IntroductionRoad traffic accidents are a major cause of injury and trauma in Uganda, of which head injuries are a major cause of morbidity and mortality among casualties.ObjectivesTo determine the leading cause of head injuries, factors associated and the outcomes.MethodsA retrospective study was carried out. Pretested questionnaires were filled in from the Records department on patients with head injuries in the

D Busingye; E Bua

2010-01-01

311

Factors Influencing Online Social Interactions  

Microsoft Academic Search

\\u000a Popular discourse provides glimpses of the relationship between social motives and user experience. In this paper, factors\\u000a influencing social interactions with seven popular social networking sites are studied in the Indian context. Relatively a\\u000a novel method of focused unstructured interview technique with adaptation from triadic sorting is used to unearth the motivation\\u000a and behavior of the user. It indicates subtle

Ravi Shankar

312

Hypoxia-Inducible Factor 1  

Microsoft Academic Search

\\u000a Hypoxia-inducible factor 1 (HIF-1) mediates adaptive responses to hypoxia by activating the transcription of hundreds of target\\u000a genes. The expression and activity of HIF-1 are oxygen-regulated, which provides a direct mechanism for transducing changes\\u000a in cellular oxygenation to changes in gene expression. HIF-1 regulates the expression of genes encoding proteins that play\\u000a key roles in mediating the switch to glycolytic

Gregg L. Semenza

313

Human factors in waste management  

SciTech Connect

This article examines the role of human factors in radioactive waste management. Although few problems and ergonomics are special to radioactive waste management, some problems are unique especially with long term storage. The entire sociotechnical system must be looked at in order to see where improvement can take place because operator errors, as seen in Chernobyl and Bhopal, are ultimately the result of management errors.

Moray, N. [Univ. of Illinois, Urbana, IL (United States)

1994-10-01

314

Dynamic stress-concentration factors  

Microsoft Academic Search

The problem of the response of structural discontinuities to short-duration stress pulses is studied experimentally. Employing\\u000a explosively induced stress pulses in thin plastic plates containing central circular holes, a dynamic stress-concentration\\u000a factor is determined as a function of pulse frequency. It is concluded, for the loading case, that the dynamic stress concentration\\u000a is significantly lower than the static value.

Richard Shea

1964-01-01

315

Perinatal risk factors for neuroblastoma.  

PubMed

Neuroblastoma is the most common cancer among infants, suggesting an etiologic role for prenatal factors. In this case-cohort study, neuroblastoma cases (n = 529) diagnosed between 1985 and 2001 were identified from the New York State Cancer Registry and were matched to the electronic birth records for 1983-2001 from New York State and New York City. Controls (n = 12,010) were selected from the same birth cohorts. Analysis was stratified by age at diagnosis, with one to six months (younger infants), seven to 18 months (older infants), and older than 18 months (older children) analyzed separately. Perinatal exposure data was obtained from the birth certificates. No risk factors were identified to be consistently associated with risk across all three age groups. Generally, more risk factors were identified as associated with neuroblastoma among younger infants relative to older ages, including high birth weight, heavier maternal gestational weight gain, maternal hypertension, older maternal age, ultrasound, and respiratory distress. Among older infants, low birth weight was associated with increased risk while heavier maternal gestational weight gain was protective. In the oldest age group, first born status, primary cesarean delivery, prolonged labor and premature rupture of the membranes were associated with increased risk. PMID:18941915

McLaughlin, Colleen C; Baptiste, Mark S; Schymura, Maria J; Zdeb, Michael S; Nasca, Philip C

2008-10-21

316

Risk factors of placental abruption  

PubMed Central

Background: Placental abruption is one of the most common causes of bleeding during pregnancy. Multiple factors are known to be associated with increase of risk of placental abruption such as alcohol, cocaine use and cigarette smoking. The objective of this study was to identify risk factors for placental abruption in an Iranian women population. Materials and Methods: In a retrospective case – control study birth records included 78 cases with placental abruption and 780 randomly selected controls were investigated. Statistical analysis for comparing the studied risk factors between groups was performed using Pearson's Chi-square test along with presenting relevant odds ratio (OR). Results: From 7301 deliveries included in the study, 78 (1%) was complicated placental abruption. Women aged 35 or more likely for experiencing (OR = 3.650, 95% confidence interval [CL] = 1.57-6.83) and those who had a previous cesarean section (OR = 2.65, 95% CL = 3.91- 33.41) were in higher risk for placental abruption ([50 cases] 64% vs. [28 cases] 36% P < 0.01). Conclusion: The results indicate that among the placental abruption is one of the most common causes of bleeding during the pregnancy and one of the major obstetrical emergency.

Ghaheh, Hooria Seyedhosseini; Feizi, Awat; Mousavi, Maryam; Sohrabi, Davood; Mesghari, Leila; Hosseini, Zahra

2013-01-01

317

Oral direct factor Xa inhibitors.  

PubMed

Vitamin K antagonists, such as warfarin, have been the mainstay of oral anticoagulation for many decades. Although effective, warfarin has numerous limitations, including a variable dose requirement from patient to patient because of differences in dietary vitamin K intake, common genetic polymorphisms, and multiple drug interactions that affect its pharmacodynamics and metabolism. Consequently, warfarin requires frequent monitoring to ensure that a therapeutic anticoagulant effect has been achieved because excessive anticoagulation can lead to bleeding, and because insufficient anticoagulation can result in thrombosis. Such monitoring is burdensome for patients and physicians and is costly for the health care system. These limitations have prompted the development of new oral anticoagulants that target either factor Xa or thrombin. Although the path to the development of these drugs has been long, the new drugs are at least as effective and safe as warfarin, but they streamline clinical care because they can be administered in fixed doses without routine coagulation monitoring. This article focuses on rivaroxaban, apixaban, and edoxaban, the oral factor Xa inhibitors in the most advanced stages of development. After 20 years of discovery research, these agents are already licensed for several indications. Thus, the long path to finding replacements for warfarin has finally reached fruition. Therefore, development of the oral factor Xa inhibitors represents a translational science success story. PMID:23023509

Yeh, Calvin H; Fredenburgh, James C; Weitz, Jeffrey I

2012-09-28

318

Fibroblast growth factor receptor inhibitors.  

PubMed

Fibroblast growth factor receptors (FGFRs) play an important role in embryonic development, angiogenesis, wound healing, cell proliferation and differentiation. The fibroblast growth factor receptor (FGFR) isoforms have been under intense scrutiny for effective anticancer drug candidates. The fibroblast growth factor (FGF) and its receptor (FGFR) provide another pathway that seems critical to monitoring angiogenesis. Recent findings suggest that FGFR mediates signaling, regulates the PKM2 activity, and plays a crucial role in cancer metabolism. The current review also covers the recent findings on the role of FGFR1 in cancer metabolism. This paper reviews the progress, mechanism, and binding modes of recently known kinase inhibitors such as PD173074, SU series and other inhibitors still under clinical development. Some of the structural classes that will be highlighted in this review include Pyrido[2,3-d]pyrimidines, Indolin- 2-one, Pyrrolo[2,1-f][1,2,4]triazine, Pyrido[2,3-d]pyrimidin-7(8H)-one, and 1,6- Naphthyridin-2(1H)-ones. PMID:23016864

Kumar, Suneel B V S; Narasu, Lakshmi; Gundla, Rambabu; Dayam, Raveendra; J A R P, Sarma

2013-01-01

319

Transcription factors in brain injury.  

PubMed

After brain injury, neuronal genes are regulated to adjust to an altered environment; however, if neurons are damaged then genes related apoptosis are activated. Glial cells, astrocytes and microglia, respond to neuronal death by transcribing genes to enhance the survival of remaining neurons and for regeneration and repair. AP-1 transcription factors are induced in the neuronal response to injury. Depending on the AP-1 dimer combination, neuronal genes related to either apoptosis or survival are transcribed. A 35 kDa Fos-related antigen:JunD dimer is present in neurons that survive injury. Jun and JunD exists in neurons prior to undergoing apoptosis. Neuronal death activates gene expression in astrocytes and microglia. NFk beta transcription factors are induced in astrocytes reacting to neuronal injury. In the microglial response, STATs appear to be activated to regulate gene transcription. These transcription factors that modulate the genes involved in the cellular processes of brain injury are examined in this review. PMID:9302571

Pennypacker, K

1997-10-01

320

Academic Success Factors: An IT Student Perspective  

ERIC Educational Resources Information Center

Numerous studies have identified causal factors for academic success. Factors vary from personal factors, such as cognitive style (McKenzie & Schweitzer, 2001), to social factors, such as culture differences (Aysan, Tanriogen, & Tanriogen, 1996). However, in these studies it is re-searchers who theorized the causal dimensions and hypothesized the…

Zhang, Aimao; Aasheim, Cheryl L.

2011-01-01

321

Neuroprotection by drug-induced growth factors  

Microsoft Academic Search

Growth factors are a heterogeneous group of polypeptides that act through specific receptors to regulate cell growth, proliferation, development, differentiation and regeneration. Nerve growth factor (NGF) and transforming growth factor-beta1 (TGF-?1) are members of this group. The increasing evidence points out the important role of these two factors in developmental nervous system as well as in the pathogenesis processes of

Yuan Zhu; Josef Krieglstein

2003-01-01

322

The contribution of human factors to AMWTP  

Microsoft Academic Search

The importance of human factors in plant design is well recognized. British Nuclear Fuels (BNFL) has invested in human factors expertise, and this is illustrated in the design of the Advanced Mixed Waste Treatment Project (AMWTP). The main purpose is to ensure the safety and operability of the plant and equipment from a human factors perspective. Various human factors techniques

J. Reed

2002-01-01

323

Paracrine factors and the regulation of spermatogenesis  

Microsoft Academic Search

Main problem: Although the gonadotropins and testosterone are required for normal spermatogenesis, it is believed that local control factors regulate spermatogenesis. For many years these regulatory factors had not been identified. Over the past five years, a number of growth factors have been identified in testis or isolated testicular cell types or secretions. Growth factors are key regulatory molecules which

C. S. Niederberger; S. Shubhada; S. J. Kim; D. J. Lamb

1993-01-01

324

Factors Influencing Attitude of Youth Towards Entrepreneurship  

Microsoft Academic Search

The study was carried out to investigate the attitude of youth towards entrepreneurship programs. It was aimed at identifying the capacity factors of potential youth entrepreneurs and the critical external factors influencing their attitude towards entrepreneurship programs. It was also aimed at determining the level of influence of these factors and identifying the perceived enhancing factors and inhibitions on the

E. A. Dioneo-Adetayo

2006-01-01

325

Regulation of transcription factor function by phosphorylation  

Microsoft Academic Search

Changes in protein phosphorylation represent a mechanism that is frequently employed by cells to regulate transcription factor activity. In response to alterations in the extracellular environment, signal transduction pathways target transcription factors, transcriptional coregulators and chromatin-modifying factors, leading to their phosphorylation by protein kinases or dephosphorylation by protein phosphatases. These modifications either positively or negatively regulate transcription factor activity to

A. J. Whitmarsh

2000-01-01

326

The autoactivation of rabbit hageman factor  

PubMed Central

Proteolytic cleavage and activation of isolated, single chain, zymogen Hageman factor was observed in the presence of kaolin alone. The rate of cleavage of kaolin-bound Hageman factor was enhanced 50-fold by the presence of prekallikrein and high molecular weight kininogen. The two-chain 82,000 dalton form of activated Hageman factor (?-HF(a)) also cleaved kaolin- bound single-chain Hageman factor in a dose-dependent manner, yielding fragments of 28,000 and, 50,000 dahons under reducing conditions. Cleavage of kaolin-bound single-chain Hageman factor was not inhibited by preincubation with diisopropylfluorophosphate (12 mM) for 10 min, but long-term incubation of Hageman factor with diisopropylfluorophosphate (up to 48 h) resulted in inhibition of cleavage of kaolin-bound Hageman factor to an extent proportional to the inhibition of procoagulant Hageman factor activity. Hageman factor cleavage was maximal when the kaolin concentration was {approximately} 10-fold greater than the Hageman factor concentration (wt:wt), and was partially inhibited by high molecular weight kininogen. Kaolin-bound Hageman factor cleaved clotting factor XI in an amount which correlated with the extent of cleavage of the Hageman factor. These findings are compatible with the concept that single-chain Hageman factor and ?- HF(a), are both capable of cleaving and activating kaolin-bound Hageman factor and that a close molecular association of kaolin-bound Hageman factor molecules is required for this reaction.

Wiggins, RC; Cochrane, CC

1979-01-01

327

The factorization of the ninth Fermat number  

Microsoft Academic Search

In this paper we exhibit the full prime factorization of the ninth Fermat number Fg = 2512 + 1 . It is the product of three prime factors that have 7, 49, and 99 decimal digits. We found the two largest prime factors by means of the number field sieve, which is a factoring algorithm that depends on arithmetic in

H. W. Lenstra; M. S. Manasse; J. M. Pollard

1993-01-01

328

Electroweak form factors of the Skyrmion  

SciTech Connect

The electroweak form factors of baryons are studied in the semiclassical approximation to the Skyrme model. General expressions for the form factors are given for arbitrary choices of the Skyrme-model Lagrangian. They are applied to the original two-parameter Skyrme model to compute the electric, magnetic, and axial-vector form factors of the nucleon and the electromagnetic nucleon-..delta.. transition form factors. The dependence of the form factors on the momentum transfer is compared with phenomenological dipole parametrizations.

Braaten, E.; Sze-Man Tse; Willcox, C.

1986-09-01

329

Tolerance factor for pyrochlores and related structures.  

PubMed

In this work a new empirical tolerance factor for compounds with pyrochlore structure is proposed. This suggested tolerance factor is based on experimental structural data and on the tolerance factors proposed. However, since it does not depend on the structural data, this new tolerance factor permits the prediction of some properties of these compounds directly. Also, a good structure stability field for the pyrochlore formation is observed when this tolerance factor is used. PMID:24056352

Mouta, R; Silva, R X; Paschoal, C W A

2013-09-13

330

Host Factors, Parasite Factors, and External Factors Involved in the Pathogenesis of Filarial Infections  

Microsoft Academic Search

This chapter describes host, parasite, and extrinsic factors independent of the immune system that contribute to filarial\\u000a pathogenesis. Those with past infection with lymphatic filariasis but with current inflammation or clinical pathology have\\u000a been the individuals most studied in the past. A significant proportion of patients in filarial endemic areas with hydroceles\\u000a and lymphedema have active current filarial infection as

David O. Freedman

331

Understanding adverse events: human factors.  

PubMed Central

(1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole.

Reason, J

1995-01-01

332

Hemostatic variables in Japanese and Caucasian men. Plasma fibrinogen, factor VIIc, factor VIIIc, and von Willebrand factor and their relations to cardiovascular disease risk factors.  

PubMed

Mortality rates of coronary heart disease are much lower and hemorrhagic stroke rates are higher in Japanese than in Caucasians. To investigate whether population differences in plasma concentrations of coagulation factors are consistent with these mortality differences, the authors examined, in 1987, a total of 136 men aged 34-55 years in four different samples: rural Japanese living in Akita, Japan; urban Japanese living in Osaka, Japan; and Japanese Americans and Caucasian Americans living in Minneapolis-St. Paul, Minnesota. The mean plasma fibrinogen level in Caucasians was 290 mg/dl, which was significantly higher than that in each of the Japanese samples (223-250 mg/dl; test for difference: p less than 0.001). The mean coagulation activities of factor VII and factor VIII (factor VIIc and factor VIIIc) were higher in Caucasian and Japanese Americans than in rural and urban Japanese (p less than 0.01 for factor VIIc and p = 0.03 for factor VIIIc). von Willebrand factor did not differ significantly across the populations. The relations of these coagulation factors with other cardiovascular risk factors (age, body mass index (weight (kg)/height (m)2), blood pressure, serum total cholesterol, serum triglyceride, cigarette smoking, and alcohol intake) were also examined. Mean plasma fibrinogen was consistently higher in current smokers than in nonsmokers within each sample. Factor VIIc and factor VIIIc levels were positively associated with serum total cholesterol and serum triglyceride. No consistent associations were seen between von Willebrand factor and cardiovascular risk factors. After the authors controlled for these covariates, mean fibrinogen and factor VIIc levels remained significantly different, but factor VIIIc levels did not. Different levels of coagulation factors across these samples are probably attributable to differences in environmental factors, especially diet, as well as genetic differences between Caucasians and Japanese. Furthermore, the differences in plasma fibrinogen and factor VIIc levels may explain part of the difference in mortality from cardiovascular disease across these populations. PMID:2510500

Iso, H; Folsom, A R; Wu, K K; Finch, A; Munger, R G; Sato, S; Shimamoto, T; Terao, A; Komachi, Y

1989-11-01

333

Modifications of Coronary Risk Factors  

PubMed Central

In addition to the revascularization and glycemic management interventions assigned at random, the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) design includes the uniform control of major coronary artery disease risk factors, including dyslipidemia, hypertension, smoking, central obesity, and sedentary lifestyle. Target levels for risk factors were adjusted throughout the trial to comply with changes in recommended clinical practice guidelines. At present, the goals are low-density lipoprotein cholesterol <2.59 mmol/L (<100 mg/dL) with an optional goal of <1.81 mmol/L (<70 mg/dL); plasma triglyceride level <1.70 mmol/L (<150 mg/dL); blood pressure level <130 mm Hg systolic and <80 mm Hg diastolic; and smoking cessation treatment for all active smokers. Algorithms were developed for the pharmacologic management of dyslipidemia and hypertension. Dietary prescriptions for the management of glycemia, plasma lipid profiles, and blood pressure levels were adapted from existing clinical practice guidelines. Patients with a body mass index >25 were prescribed moderate caloric restriction; after the trial was under way, a lifestyle weight-management program was instituted. All patients were formally prescribed both endurance and resistance/flexibility exercises, individually adapted to their level of disability and fitness. Pedometers were distributed as a biofeedback strategy. Strategies to achieve the goals for risk factors were designed by BARI 2D working groups (lipid, cardiovascular and hypertension, and nonpharmacologic intervention) and the ongoing implementation of the strategies is monitored by lipid, hypertension, and lifestyle intervention management centers.

Albu, Jeanine; Gottlieb, Sheldon H.; August, Phyllis; Nesto, Richard W.; Orchard, Trevor J.

2009-01-01

334

[Prognostic factors uterine corpus cancer].  

PubMed

The accumulated clinico-pathological dates and recent molecular biological studies have identified several prognostic factors for endometrial cancers. FIGO staging has taken into consideration of the tumor expansion and is the most important predictor in evaluating patient outcome. Characteristics of tumor biology, such as morphology of tumor and depth of invasion are also important prognostic considerations. Molecular markers indicating genetic/molecular events in cancer biology appear to be the 3rd predictors in estimating the prognosis. Finally, treatment of uterine corpus cancer can be directly related to prognosis. Postoperative chemotherapy is gradually taking precedence over irradiation in considering evidence-based medicine. PMID:17197744

Inoue, Masaki

2006-12-01

335

Factorization in Quantized Weyl Algebras  

Microsoft Academic Search

Let $q$ be a nonzero scalar. The quantized Weyl algebra $\\\\cal{A}_{1}^{q} (F)\\u000a$ is a noncommutative ring generated by variables $x,y$ such that $yx=qxy+1$.\\u000aWe study factorization in $\\\\cal{A}_{1}^{q}(F)$ and consider irreducible and\\u000aprime elements. We classify irreducible quadratic forms and identify two\\u000aimportant classes. A result on Ore extensions is needed to describe prime\\u000aquadratic forms.\\u000a Suppose $R$ is

Candis Cookand Kenneth Price; Kenneth Price

2005-01-01

336

Factors Affecting the Earth's Weather  

NSDL National Science Digital Library

This Classroom Connectors lesson plan discusses factors affecting the weather on Earth. Students learn about solar radiation, wind circulation, precipitation, and biomes that result from weather patterns. The site provides goals, objectives, an outline, time required, materials, activities, and closure ideas for the lesson. The Classroom Connectors address content with an activity approach while incorporating themes necessary to raise the activity to a higher cognition level. The major motivation is to employ instructional strategies that bring the students physically and mentally into touch with the science they are studying.

337

Endocrine factors of pair bonding.  

PubMed

Throughout literature--fiction and poetry, fine arts and music--falling in love and enjoying romantic love plays a central role. While several psychosocial conceptions of pair attachment consider the participation of hormones, human endocrinology has dealt with this theme only marginally. According to some authors in addictology, falling in love shows some signs of hormonal response to stressors with changes in dopamine and serotonin signalling and neurotrophin (transforming growth factor b) concentration. Endorphins, oxytocin and vasopressin may play a role during the later phases of love. However, proof of hormonal events associated with love in humans has, until recently, been lacking. PMID:18780641

Stárka, L

2007-01-01

338

Weak-shock reflection factors  

SciTech Connect

The purpose of this paper is to compare reflection factors for weak shocks from various surfaces, and to focus attention on some unsolved questions. Three different cases are considered: square-wave planar shock reflection from wedges; square-wave planar shock reflection from cylinders; and spherical blast wave reflection from a planar surface. We restrict ourselves to weak shocks. Shocks with a Mach number of M{sub O} < 1.56 in air or with an overpressure of {Delta}{sub PI} < 25 psi (1.66 bar) under normal ambient conditions are called weak.

Reichenbach, H. [Ernst Mach Inst., Freiburg (Germany); Kuhl, A.L. [Lawrence Livermore National Lab., El Segundo, CA (United States)

1993-09-07

339

Nucleon Form Factors from BLAST  

NASA Astrophysics Data System (ADS)

The BLAST (Bates Large Acceptance Spectrometer Toroid) experiment has been carried out at the MIT-Bates Linear Accelerator Center to study spin-dependent electron scattering from protons and deuterons with small systematic uncertainties. The experiment used a longitudinally polarized, intense electron beam stored in the Bates South Hall Ring in combination with isotopically pure, highly-polarized internal targets of polarized hydrogen and vector- and tensor-polarized deuterium from an atomic beam source. The BLAST data have been used to extract precise results for the elastic form factor ratios GE/GM of the proton and the neutron at low momentum transfer.

Kohl, Michael

2009-08-01

340

[Prognostic factors in psoriatic arthritis].  

PubMed

Peripheral psoriatic arthritis is an inflammatory and progressive disease; its burden, either at the structural level or the function and quality of life, is similar to other chronic poliarthritidies. In spite of treatment with synthetic or biologic DMARDs, remission is only achieved in about 30% of the patients. From a clinical point of view, persistent joint activity (tender and swollen joints) is a factor leading to joint damage progression. These data indicate the need for a tight follow up and treatment of the patients. PMID:22257679

Fernández Sueiro, José Luis; Lema Gontad, José Manuel

2012-01-17

341

Environmental risk factors for psychopathology.  

PubMed

In the past all psychopathologies were viewed as caused by the environment. Later on case-control and family-based studies of major psychiatric disorders found genetic associations, but in many cases these findings did not survive replications. A gene-environment approach gave new hope for possible associations. Gene environment correlations emphasized that the relationship are bidirectional. However, recent meta-analyses raised doubts about the consistency of these findings as well. The review summarizes the current view on the environmental factors in the major psychopathologies. PMID:20733257

Schlossberg, Karin; Massler, Anda; Zalsman, Gil

2010-01-01

342

Salmonella-secreted Virulence Factors  

SciTech Connect

In this short review we discuss secreted virulence factors of Salmonella, which directly affect Salmonella interaction with its host. Salmonella secretes protein to subvert host defenses but also, as discussed, to reduce virulence thereby permitting the bacteria to persist longer and more successfully disperse. The type III secretion system (TTSS) is the best known and well studied of the mechanisms that enable secretion from the bacterial cytoplasm to the host cell cytoplasm. Other secretion systems include outer membrane vesicles, which are present in all Gram-negative bacteria examined to date, two-partner secretion, and type VI secretion will also be addressed. Excellent reviews of Salmonella secreted effectors have focused on themes such as actin rearrangements, vesicular trafficking, ubiquitination, and the activities of the virulence factors themselves. This short review is based on S. Typhimurium infection of mice because it is a model of typhoid like disease in humans. We have organized effectors in terms of events that happen during the infection cycle and how secreted effectors may be involved.

Heffron, Fred; Niemann, George; Yoon, Hyunjin; Kidwai, Afshan S.; Brown, Roslyn N.; McDermott, Jason E.; Smith, Richard D.; Adkins, Joshua N.

2011-05-01

343

Male factor infertility and ART  

PubMed Central

For years, the management and treatment of male factor infertility has been ‘experience' and not ‘evidence' based. Although not evidence-based, current clinical practice involves extensive use of assisted reproductive techniques (ART). Where specific treatments are not indicated or have failed, ART have become popular adjunctive treatments for alleviating male factor infertility. According to the limited evidence available, intrauterine insemination (IUI) may be considered as a first-line treatment in a couple in which the female partner has a normal fertility status and at least 1×106 progressively motile spermatozoa are recovered after sperm preparation. If no pregnancy is achieved after 3–6 cycles of IUI, optimized in vitro fertilization (IVF) can be proposed. When less than 0.5×106 progressively motile spermatozoa are obtained after seminal fluid processing or sperm are recovered surgically from the testis or epididymis, intracytoplasmic sperm injection (ICSI) should be performed. Although the outcome of no other ART has ever been scrutinized as much before, no large-scale ‘macroproblems' have as yet been observed after ICSI. Yet, ICSI candidates should be rigorously screened before embarking on IVF or ICSI, and thoroughly informed of the limitations of our knowledge on the hereditary aspects of male infertility and the safety aspects of ART.

Tournaye, Herman

2012-01-01

344

Factors affecting ballasted flocculation reactions.  

PubMed

Ballasted flocculation represents a relatively new technology that shows promise of bringing improvements to the field of water and wastewater treatment. Ballasted flocculation involves the addition of a ballasting agent (high-density microsand, sp gr = 2.65) to a chemically stabilized and coagulated suspension of particulate solids. Tests were conducted to determine the effect of eight independent parameters on the settling velocity of the resulting floc. Measurements showed settling velocities ranging from approximately 100 m/h for 0.5-mm diameter particles to as high as 380 m/h for particles having effective diameters up to 7 mm. Settling velocities for discrete microsand particles and discrete ballasted flocs were found to fit conventional settling theory with reasonable accuracy. The most important factors contributing to the benefits of ballasted flocculation are the large floc sizes that can be maintained, the greater roundness of the floc particles, and a lower shape factor for the ballasted floc, which all contribute to higher settling rates. Higher settling rates allow for substantially smaller sedimentation units and decreased capital costs. PMID:12837033

Young, James C; Edwards, Findlay G

345

Factors affecting outcomes in colonoscopy.  

PubMed

There are many factors that influence successful outcomes in colonoscopy. The aims of this study were to evaluate these factors and determine ways to improve outcomes. All participants (N=229) who underwent planned colonoscopy between July and September 2004 were retrospectively included. Participants included 118 men and 111 women with a mean age of 59 years. Completion rate was 92%. Reasons of failure included poor bowel preparation (2.2%, p< .025), bowel looping (2.2%, p< .025), participant discomfort (1.3%), and obstructing lesion (1.3%). Mean midazolam dose was 3.8 mg. Three participants (1.3%) had midazolam alone, and all had complete colonoscopy. One hundred thirty-three participants (60.7%) had additional meperidine, with a completion rate of 94%. Eighty three participants (37.9%) had additional meperidine and Buscopan, with a completion rate reduced to 89.2%. There was no correlation between sedatives used and completion rate. Completion rate of colonoscopy in our unit was acceptable at 92%. A combination of midazolam and meperidine gave the best completion rates (94%). The two main reasons for incompletion were poor bowel preparation and excessive bowel looping. PMID:18300826

Selehi, Seema; Leung, Edmund; Wong, Ling

346

Suicide Protective and Risk Factors for Sexual Minority Youth: Applying the Cumulative Factor Model  

Microsoft Academic Search

This report explores suicide protective and risk factors for lesbian, gay and bisexual (LGB) youth and offers a Cumulative Factor Model constructed from these factors. Numerous studies to date have concluded that a youth's sexual minority identity is a key risk factor for suicide. Few studies however have explored the internal and external protective factors that may cumulate to increase

Philip A. Rutter

2008-01-01

347

Implications of Indeterminate Factor-Error Covariances for Factor Construction, Prediction, and Determinacy  

ERIC Educational Resources Information Center

The assumptions of the model for factor analysis do not exclude a class of indeterminate covariances between factors and error variables (Grayson, 2003). The construction of all factors of the model for factor analysis is generalized to incorporate indeterminate factor-error covariances. A necessary and sufficient condition is given for…

Krijnen, Wim P.

2006-01-01

348

Taking the Error Term of the Factor Model into Account: The Factor Score Predictor Interval  

ERIC Educational Resources Information Center

The problem of factor score indeterminacy implies that the factor and the error scores cannot be completely disentangled in the factor model. It is therefore proposed to compute Harman's factor score predictor that contains an additive combination of factor and error variance. This additive combination is discussed in the framework of classical…

Beauducel, Andre

2013-01-01

349

A Test for the Number of Factors in an Approximate Factor Model  

Microsoft Academic Search

An important issue in applications of multifactor models of asset returns is the appropriate number of factors. Most extant tests for the number of factors are valid only for strict factor models, in which diversifiable returns are uncorrelated across assets. In this paper, the authors develop a test statistic to determine the number of factors in an approximate factor model

Gregory Connor; Robert A. Korajczyk

1993-01-01

350

Factorization of polynomials over finite fields and factorization of primes in algebraic number fields  

Microsoft Academic Search

Based on Kummer Theorem, we study the deterministic complexity of two factorization problems: polynomial factorization over finite fields and prime factorization in algebraic number fields. We show that factoring polynomials of degree n in Fp[x], with p prime, is polynimially equivalent to factoring p in algebraic number field of extension degree n over Q, where p is “regular” with respect

Ming-Deh A. Huang

1984-01-01

351

On z-factorization and c-factorization of standard episturmian words  

Microsoft Academic Search

Ziv–Lempel and Crochemore factorization are two kinds of factorizations of words related to text processing. In this paper, we find these factorizations for standard epiesturmian words. Thus the previously known c-factorization of characteristic Sturmian words is provided as a special case. Moreover, the two factorizations are compared.

N. Ghareghani; M. Mohammad-Noori; P. Sharifani

2011-01-01

352

Production of growth factors related to fibroblast growth factor and platelet-derived growth factor by human embryonal carcinoma cells  

Microsoft Academic Search

Summary  Previous studies have demonstrated that mouse embryonal carcinoma (EC) cells produce at least two growth factors: one related\\u000a to platelet-derived growth factor (PDGF) and another related to basic fibroblast growth factor (FGFb). Since human EC cell\\u000a lines are being used with increased frequency, the current study examined whether human EC cells produce growth factors, in\\u000a particular those produced by mouse

Jay Tiesman; Anita Meyer; Ronald N. Hines; Angie Rizzino

1988-01-01

353

Hepatocyte Growth Factor, Keratinocyte Growth Factor, Their Receptors, Fibroblast Growth Factor Receptor2, and the Cells of the Cornea  

Microsoft Academic Search

Purpose. The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cul- tures of human corneal epithelial, stromal fibroblast, and endothelial cells, as well as ex vivo corneal epithelium, endothelial cells transfected with the

Steven E. Wilson; Joel W. Walker; Eric L. Chwang; Yu-Guang He

354

A Computer Program to Relate Factors Across Separately Factor Analyzed Variable Domains  

ERIC Educational Resources Information Center

A Fortran IV program is presented which will cross-correlate least squares estimated factor scores across separately factor analyzed variable domains without the tedious necessity of actually calculating the factor scores. (RC)

Morris, John D.; Guertin, Wilson H.

1976-01-01

355

A Computer Program to Relate Factors Across Separately Factor Analyzed Variable Domains  

ERIC Educational Resources Information Center

|A Fortran IV program is presented which will cross-correlate least squares estimated factor scores across separately factor analyzed variable domains without the tedious necessity of actually calculating the factor scores. (RC)|

Morris, John D.; Guertin, Wilson H.

1976-01-01

356

Inhibition of Hageman factor, plasma thromboplastin antecedent, thrombin and other clotting factors by phenylglyoxal hydrate (38500).  

PubMed

Exposure of purified Hageman factor (HF, Factor XII) to phenylglyoxal hydrate (PHG), an agent reacting with arginine residues in protein, inhibited its coagulant properties upon subsequent exposure of negatively charged agents. Once HF had been exposed to kaolin or ellagic acid, however, subsequent addition of PHG was much less inhibitory. PHG had no effect upon the ability of HF to bind to negatively charged surfaces. PGH also inhibited preparations of activated PTA (Factor XI) and thrombin, and, when incubated with plasma, reduced the titer of coagulable fibrinogen, PTA Christmas factor (Factor IX), antihemophilic factor (Factor VIII), Factor VII, Stuart factor (Factor X), proaccelerin (Factor V) and prothrombin (Factor II), and to a lesser degres, HF. PMID:236567

Radnoff, O D; Saito, H

1975-01-01

357

Clinical Factors Associated with PANDAS  

PubMed Central

Objective To explore associated clinical factors in children with pediatric autoimmune neuropsychiatric disorders associated with streptococcus (PANDAS). Study design Children with tics and/or OCD (n = 109) were examined by personal and family history, diagnostic interview, physical examination, medical record review, and measurement of baseline levels of streptococcal antibodies. Results Significant group differences were found on several variables, such that those diagnosed with PANDAS (versus without PANDAS) were more likely to have had dramatic onset; definite remissions; remission of neuropsychiatric symptoms during antibiotic therapy; a history of tonsillectomies/adenoidectomies; evidence of GAS infection, and clumsiness. Conclusion The identification of clinical features associated with PANDAS should assist in delineating risks for this subtype of OCD/tics.

Murphy, Tanya K.; Storch, Eric A.; Lewin, Adam B.; Edge, Paula J.; Goodman, Wayne K.

2011-01-01

358

[Factors that alter taste perception].  

PubMed

Dysfunction of taste perception is a significant problem for many individuals. Taste anomalies may affect health not only by directly affecting liquid and solid food intake, but also by creating a state of depression due to the loss of an important source of pleasure. Many factors alter taste perception, such as lesions of the oral mucosa, cigarette smoking, radiation, chemotherapy, renal disease, hepatitis, leprosy, hormones, nutrition, use of dentures, medications, and aging. Gum or ice chewing may temporarily help loss of taste. Patients should be encouraged to chew their food thoroughly, alternating the sides of the mouth, or alternating different foods. Unfortunately, in many cases there is no cure for this alteration, and patience is then the only possibility. PMID:2129567

Maffeis, E R; Silva-Netto, C R

359

Psychological factors affecting equine performance.  

PubMed

For optimal individual performance within any equestrian discipline horses must be in peak physical condition and have the correct psychological state. This review discusses the psychological factors that affect the performance of the horse and, in turn, identifies areas within the competition horse industry where current behavioral research and established behavioral modification techniques could be applied to further enhance the performance of animals. In particular, the role of affective processes underpinning temperament, mood and emotional reaction in determining discipline-specific performance is discussed. A comparison is then made between the training and the competition environment and the review completes with a discussion on how behavioral modification techniques and general husbandry can be used advantageously from a performance perspective. PMID:23016987

McBride, Sebastian D; Mills, Daniel S

2012-09-27

360

Psychological factors affecting equine performance  

PubMed Central

For optimal individual performance within any equestrian discipline horses must be in peak physical condition and have the correct psychological state. This review discusses the psychological factors that affect the performance of the horse and, in turn, identifies areas within the competition horse industry where current behavioral research and established behavioral modification techniques could be applied to further enhance the performance of animals. In particular, the role of affective processes underpinning temperament, mood and emotional reaction in determining discipline-specific performance is discussed. A comparison is then made between the training and the competition environment and the review completes with a discussion on how behavioral modification techniques and general husbandry can be used advantageously from a performance perspective.

2012-01-01

361

Kleptomania and Potential Exacerbating Factors  

PubMed Central

Kleptomania is an impulse control disorder that can cause significant impairment and serious consequences. Often, the condition is kept secret by the patient, and usually help is sought only when confronted by the legal consequences of the impulsive behaviors. Historically, kleptomania has been viewed from a psychodynamic perspective, and the mainstay of treatment has been psychotherapy. Recently, attempts to explain kleptomania within a neuropsychiatric paradigm have highlighted the possible links between mood disorders, addictive behaviors, and brain injury with kleptomania. These associations with kleptomania can be extrapolated to pharmacological strategies that can potentially help in treating kleptomania. A case of kleptomania, which was potentially exacerbated by multiple factors, will be reviewed. Treatment modalities used in this case, including the use of the Yale-Brown Obsessive Compulsive Scale as a surrogate marker to gauge response to treatment, will be discussed.

2011-01-01

362

Environmental factors and testicular function.  

PubMed

Over the last decades there has been a dramatic increase in the incidence of some diseases associated with the male reproductive system, including poor semen quality, testicular cancer and congenital developmental abnormalities such as cryptorchidism and hypospadias, malformations of the urethra and scrotum respectively. Based on these observations one recurring theme is the concern that certain environmental chemicals and lifestyle related factors may play a role. Early fetal life is a particularly critical time period, when the endocrine system is established and organs are developing. Although available data does not yet allow recommending, evidence based, prophylactic and/or therapeutic measures to eliminate or reduce the possible negative impact of environment/lifestyle on the male reproductive capacity, it is prudent to limit exposures of people to hormonally active chemicals. PMID:21397206

Giwercman, Aleksander; Giwercman, Yvonne Lundberg

2011-04-01

363

Form factors from lattice QCD  

SciTech Connect

Precision computation of hadronic physics with lattice QCD is becoming feasible. The last decade has seen precent-level calculations of many simple properties of mesons, and the last few years have seen calculations of baryon masses, including the nucleon mass, accurate to a few percent. As computational power increases and algorithms advance, the precise calculation of a variety of more demanding hadronic properties will become realistic. With this in mind, I discuss the current lattice QCD calculations of generalized parton distributions with an emphasis on the prospects for well-controlled calculations for these observables as well. I will do this by way of several examples: the pion and nucleon form factors and moments of the nucleon parton and generalized-parton distributions.

Dru Renner

2012-04-01

364

Occupational factors and pancreatic cancer.  

PubMed Central

The relation between occupational factors and pancreatic cancer has been studied by two different approaches: a population based case-control study with two series of controls and a retrospective cohort study based on register data. With both approaches, some support was found for an association with occupational exposure to petroleum products. Associations were also indicated with exposure to paint thinner (case-control study) and work in painting and in paint and varnish factories (cohort study), for exposure to detergents, floor cleaning agents, or polish (case-control study) and with floor polishing or window cleaning (cohort study), and for exposure to refuse (case-control study) and work in refuse disposal plants (cohort study).

Norell, S; Ahlbom, A; Olin, R; Erwald, R; Jacobson, G; Lindberg-Navier, I; Wiechel, K L

1986-01-01

365

[Etiopathogenic factors of arterial hypertension].  

PubMed

High blood pressure of unknown etiology has been related to many pathogenetic factors, mainly dietary salt intake, mental stress, alcohol consumption, sedentary living and aging. Hypertension is more common in condition such as obesity and diabetes mellitus. Sustained elevation of arterial pressure is mediated by vasoconstriction in response to catecholamine release and activation of the renin-angiotensin-aldosterone system. In obese and diabetic subjects, insulin resistance and hyperinsulinemia have been found to be related to development of hypertension. The hypertension phenotype may correspond to many different genotypes codifying various alterations of hormone and receptor function, as well as inherited diseases linked to hypertension. An outstanding epidemiologic example of how hypertension may appear in a community is found in Easter Island. Hypertension among native adults increased from 3 to 30% in a 10 year period, in relation to influx of tourism and changes in salt intake and diet. PMID:1341800

Pérez-Olea, J

1992-06-01

366

Factors for Bioenergy Market Development  

SciTech Connect

Focusing on the development of the whole bioenergy market rather than isolated projects, this paper contributes to the identification of barriers and drivers behind bioenergy technology implementation. It presents a framework for the assessment of the potentials for bioenergy market growth to be used by decision makers in administration and industry. The conclusions are based on case studies of operating bioenergy markets in Austria, US and Sweden. Six important factors for bioenergy market growth have been identified: (1) Integration with other business, e.g. for biomass procurement, (2) Scale effects of bioenergy market, (3) Competition on bioenergy market, (4) Competition with other business, (5) National policy, (6) Local policy and local opinion. Different applications of the framework are discussed.

Roos, A.; Hektor, B.; Graham, R.L.; Rakos, C.

1998-10-04

367

Factors affecting leachate quality. Technical note  

SciTech Connect

This technical note describes factors affecting leachate quality for dredged material in confined disposal facilities (CDFs). Factors evaluated include desorption kinetics, sediment concentration, and association of PCBs with soluble and colloidal organic matter.

Brannon, J.M.; Pennington, J.C.; Myers, T.E.; Price, C.B.

1989-12-01

368

An incomplete factorization preconditioner for adaptive filtering  

NASA Astrophysics Data System (ADS)

A method for deriving an incomplete QR factorization preconditioner for adaptive filtering is proposed. The method combines a recursive inverse QR factorization with a dropping strategy. Inverse QR factorization is more efficient compared to conventional factorization methods in that it avoids direct computation of the inverse. By realizing the factorization using a series of Givens rotation, a direct calculation of the inverse Cholesky factor is possible through the use of matrix inversion lemma and some algebraic manipulation of the Givens parameters. A dropping strategy is designed to create sparseness in the inverse Cholesky factor therefore minimizing the computational complexity of the resulting algorithm. Simulation shows that the incomplete inverse Cholesky factor derived in this paper is able to reduce the spectral condition number of the autocorrelation matrix of the problem.

Ahmad, N. A.; Javed, S.

2012-09-01

369

Rheumatoid Factors in Salmonelia and Schistosoma Infections.  

National Technical Information Service (NTIS)

Rheumatodi serum factors (anti-globulin antibodies) were studied in chronic salmonella bacteriaemia associated with schistosomiasis, in acute typhoid and paratyphoid fevers, and in schistosomiasis. Rheumatoid factor existed in high frequency and high titr...

J. S. Lehman G. I. Higashi S. Bassily Z. Farid

1972-01-01

370

Limiting Factors, Enhancement and Kinetics of Biodegradation.  

National Technical Information Service (NTIS)

Studies were conducted to establish some factors limiting biodegradation by introduced microorganisms, to devise means to overcome factors limiting biodegradation, to devise and evaluate kinetic models for biodegradation, and to determine how microorganis...

M. Alexander

1995-01-01

371

Clotting Factors of Supernatant Plasma Following Cryoprecipitation.  

National Technical Information Service (NTIS)

The supernatant plasma which remains after cryoprecipitation is a useful component for transfusion therapy. However, from prior studies it was unclear how well plasma clotting factors were preserved following cryoprecipitation. Coagulation factor assays w...

G. J. Roth J. A. Eaton K. I. Tobias T. A. Rudai W. E. Kline

1973-01-01

372

Correlation of Seismic Velocities with Earthwork Factors.  

National Technical Information Service (NTIS)

The study was made to determine whether seismic data can be used to obtain satisfactory design earthwork factors for roadway excavation. The study shows an apparent correlation between seismic velocity and earthwork factor for the three types of rock stud...

T. Smith M. McCauley R. Mearns K. Baumeister

1972-01-01

373

Correlation of Seismic Velocities with Earthwork Factors.  

National Technical Information Service (NTIS)

The study was made to determine whether seismic data can be used to obtain satisfactory design earthwork factors for roadway excavation. The study shows an apparent correlation between seismic velocity and earthwork factor for the sedimentary rock types e...

T. Smith M. McCauley K. Baumeister

1972-01-01

374

Correlation of Seismic Velocities with Earthwork Factors.  

National Technical Information Service (NTIS)

The study was made to determine whether seismic data can be used to obtain satisfactory design earthwork factors for roadway excavation. The study shows an apparent correlation between seismic velocity and earthwork factor for the three metamorphic rock t...

T. Smith M. McCauley R. Mearns K. Baumeister

1972-01-01

375

Two Factor Analytic Studies of Dyslexic Subtypes.  

ERIC Educational Resources Information Center

Psychometric data from two dyslexic groups were factor analyzed to identify dyslexic subtypes. Literacy, intelligence, auditory dysfunction, and visual/verbal dysfunction factors were identified. Results were discussed in the context of previous subtype classification studies. (Author/MJL)

Hicks, Carolyn; Spurgeon, P.

1982-01-01

376

42 CFR 414.28 - Conversion factors.  

Code of Federal Regulations, 2012 CFR

...Public Health 3 2012-10-01 2012-10-01 false Conversion factors. 414.28 Section 414.28 Public Health ...SERVICES Physicians and Other Practitioners § 414.28 Conversion factors. CMS establishes CFs in accordance with...

2012-10-01

377

Regulation of transcription factor function by phosphorylation.  

PubMed

Changes in protein phosphorylation represent a mechanism that is frequently employed by cells to regulate transcription factor activity. In response to alterations in the extracellular environment, signal transduction pathways target transcription factors, transcriptional coregulators and chromatin-modifying factors, leading to their phosphorylation by protein kinases or dephosphorylation by protein phosphatases. These modifications either positively or negatively regulate transcription factor activity to facilitate a program of gene expression that results in appropriate changes in cell behavior. Protein phosphorylation and dephosphorylation can directly regulate distinct aspects of transcription factor function, including cellular localization, protein stability, protein-protein interactions and DNA binding. The phosphorylation-dependent modulation of the activities of transcriptional coregulators and chromatin-modifying factors can also control transcription factor activity. Here we review recent studies that have led to a better understanding of the mechanisms by which protein phosphorylation and dephosphorylation governs transcription factor function. PMID:11028910

Whitmarsh, A J; Davis, R J

2000-08-01

378

EXPOSURE FACTORS HANDBOOK (EXTERNAL REVIEW DRAFT) 1996  

EPA Science Inventory

This handbook provided a summary of the available statistical data on various factors used in assessing human exposure. Volume I, General Factors, includes an introduction and discussion of uncertainty and provides data for drinking water consumption, soil ingestion, inha...

379

Radioiodination of human intrinsic factor  

PubMed Central

Human intrinsic factor (IF) saturated with 60Co-labeled cyanocobalamin (60CoB12) was purified and then iodinated with 125I to yield 125I-labeled IF-60CoB12 preparations of high specific activity. Sephadex G200 and DEAE-cellulose chromatography of the iodinated IF-60CoB12 complex showed coincidence of the major 125I and the 60Co radioactivity peaks. During starch-gel electrophoresis 60Co radioactivity from noniodinated and iodinated complexes migrated to the same extent while 125I radioactivity from the iodinated complex migrated slightly further anodally than did the 60Co radioactivity. After the iodinated complex was mixed with antibody to the IF-B12 complex (antibody II) the 125I and 60Co radioactivity were: (a) precipitated in similar amounts by antiglobulin serum. (b) eluted coincidentally in the 19S region on Sephadex G200, and (c) excluded to the same extent from starch gel during electrophoresis. After equilibrium exchange of IF “blocking” antibody (antibody I) for 60Co-vitamin B12 on 125I-labeled IF. 125I radioactivity from the IF-antibody I complex: (a) was precipitated by antiglobulin serum, (b) was eluated in the 19S region on Sephadex G200 gel filtration, and (c) migrated slowly towards the anode on starch-gel electrophoresis. Urinary excretion of 60Co radioactivity in pernicious anemia patients after oral administration of 60Co-vitamin B12 bound to freshly prepared 125I-labeled IF was similar to that obtained with noniodinated intrinsic factor. These results show that iodination of IF-60CoB12 complex does not markedly alter the chromatographic, electrophoretic, antigenic, or absorption-promoting properties of IF.

Mackenzie, Iain L.; Donaldson, Robert M.; Schilling, Robert F.

1969-01-01

380

Factors affecting grip strength testing.  

PubMed

The rodent grip strength test was developed decades ago and is a putative measure of muscular strength. This test has been included in the functional observational battery (FOB) to screen for neurobehavioral toxicity, and changes in grip strength have been interpreted as evidence of motor neurotoxicity. Despite its widespread use, questions remain about what the grip strength test actually measures. In this study, potential confounders of the grip strength test were identified and tested, including operational parameters, disruption of peripheral sensory function and changes in body weight. Operational parameters (sampling rate, system type and trial angle but not trial speed) had dramatic effects on grip strength data. Doxorubicin (DX, 10 mg/kg iv) was used to cause sensory impairment. It decreased forelimb and hindlimb grip strength (by 27% and 32%, respectively, compared with controls), an effect that was correlated with degeneration of peripheral and central sensory components (distal tibial and sural nerves, dorsal funiculus of the spinal cord and dorsal, but not ventral, spinal roots). Feed restriction-induced loss of body weight (26% compared with controls) and muscle mass (20% compared with controls) reversibly decreased both forelimb and hindlimb grip strength (18% and 17%, respectively, compared with controls). Ignoring these confounding factors could potentially lead to increased data variability and inconsistency within single studies, across studies and in historical control data sets. To assist in data interpretation and evaluation of grip strength results, it is suggested that exact conditions of application of the test be reported in greater detail. Furthermore, given that the grip strength test can be influenced by factors other than true muscular strength, use of the term grip performance is proposed to better reflect the apical nature of this test. PMID:12972067

Maurissen, Jacques P J; Marable, Brian R; Andrus, Amanda K; Stebbins, Kenneth E

381

Prognostic factors in prostate cancer  

PubMed Central

Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical prostatectomy. Gleason score, tumour volume, surgical margins and Ki-67 index have the most significant prognosticators. Also the origins from the transitional zone, p53 status in cancer tissue, stage, and aneuploidy have shown prognostic significance. Progression-associated features include Gleason score, stage, and capsular invasion, but PSA is also highly significant. Progression can also be predicted with biological markers (E-cadherin, microvessel density, and aneuploidy) with high level of significance. Other prognostic features of clinical or PSA-associated progression include age, IGF-1, p27, and Ki-67. In patients who were treated with radiotherapy the survival was potentially predictable with age, race and p53, but available research on other markers is limited. The most significant published survival-associated prognosticators of prostate cancer with extension outside prostate are microvessel density and total blood PSA. However, survival can potentially be predicted by other markers like androgen receptor, and Ki-67-positive cell fraction. In advanced prostate cancer nuclear morphometry and Gleason score are the most highly significant progression-associated prognosticators. In conclusion, Gleason score, capsular invasion, blood PSA, stage, and aneuploidy are the best markers of progression in organ confined disease. Other biological markers are less important. In advanced disease Gleason score and nuclear morphometry can be used as predictors of progression. Compound prognostic factors based on combinations of single prognosticators, or on gene expression profiles (tested by DNA arrays) are promising, but clinically relevant data is still lacking.

Buhmeida, A; Pyrhonen, S; Laato, M; Collan, Y

2006-01-01

382

Prognostic factors in prostate cancer.  

PubMed

Prognostic factors in organ confined prostate cancer will reflect survival after surgical radical prostatectomy. Gleason score, tumour volume, surgical margins and Ki-67 index have the most significant prognosticators. Also the origins from the transitional zone, p53 status in cancer tissue, stage, and aneuploidy have shown prognostic significance. Progression-associated features include Gleason score, stage, and capsular invasion, but PSA is also highly significant. Progression can also be predicted with biological markers (E-cadherin, microvessel density, and aneuploidy) with high level of significance. Other prognostic features of clinical or PSA-associated progression include age, IGF-1, p27, and Ki-67. In patients who were treated with radiotherapy the survival was potentially predictable with age, race and p53, but available research on other markers is limited. The most significant published survival-associated prognosticators of prostate cancer with extension outside prostate are microvessel density and total blood PSA. However, survival can potentially be predicted by other markers like androgen receptor, and Ki-67-positive cell fraction. In advanced prostate cancer nuclear morphometry and Gleason score are the most highly significant progression-associated prognosticators. In conclusion, Gleason score, capsular invasion, blood PSA, stage, and aneuploidy are the best markers of progression in organ confined disease. Other biological markers are less important. In advanced disease Gleason score and nuclear morphometry can be used as predictors of progression. Compound prognostic factors based on combinations of single prognosticators, or on gene expression profiles (tested by DNA arrays) are promising, but clinically relevant data is still lacking. PMID:16759347

Buhmeida, A; Pyrhönen, S; Laato, M; Collan, Y

2006-04-03

383

Physiological factors influencing capillary growth.  

PubMed

(1) Angiogenesis (growth of new capillaries from an existing capillary bed) may result from a mismatch in microvascular supply and metabolic demand (metabolic error signal). Krogh examined the distribution and number of capillaries to explore the correlation between O(2) delivery and O(2) consumption. Subsequently, the heterogeneity in angiogenic response within a muscle has been shown to reflect either differences in fibre type composition or mechanical load. However, local control leads to targetted angiogenesis in the vicinity of glycolytic fibre types following muscle stimulation, or oxidative fibres following endurance training, while heterogeneity of capillary spacing is maintained during ontogenetic growth. (2) Despite limited microscopy resolution and lack of specific markers, Krogh's interest in the structure of the capillary wall paved the way for understanding the mechanisms of capillary growth. Angiogenesis may be influenced by the response of perivascular or stromal cells (fibroblasts, macrophages and pericytes) to altered activity, likely acting as a source for chemical signals modulating capillary growth such as vascular endothelial growth factor. In addition, haemodynamic factors such as shear stress and muscle stretch play a significant role in adaptive remodelling of the microcirculation. (3) Most indices of capillarity are highly dependent on fibre size, resulting in possible bias because of scaling. To examine the consequences of capillary distribution, it is therefore helpful to quantify the area of tissue supplied by individual capillaries. This allows the spatial limitations inherent in most models of tissue oxygenation to be overcome generating an alternative approach to Krogh's tissue cylinder, the capillary domain, to improve descriptions of intracellular oxygen diffusion. PMID:20946238

Egginton, S

2011-07-01

384

Complement fixation by rheumatoid factor.  

PubMed Central

The capacity for fixation and activation of hemolytic complement by polyclonal IgM rheumatoid factors (RF) isolated from sera of patients with rheumatoid arthritis and monoclonal IgM-RF isolated from the cryoprecipitates of patients with IgM-IgG mixed cryoglobulinemia was examined. RF mixed with aggregated, reduced, and alkylated human IgG (Agg-R/A-IgG) in the fluid phase failed to significantly reduce the level of total hemolytic complement, CH50, or of individual complement components, C1, C2, C3, and C5. However, sheep erythrocytes (SRC) coated with Agg-R/A-IgG or with reduced and alkylated rabbit IgG anti-SRC antibody were hemolyzed by complement in the presence of polyclonal IgM-RF. Human and guinea pig complement worked equally well. The degree of hemolysis was in direct proportion to the hemagglutination titer of the RF against the same coated cells. Monoclonal IgM-RF, normal human IgM, and purified Waldenström macroglobulins without antiglobulin activity were all inert. Hemolysis of coated SRC by RF and complement was inhibited by prior treatment of the complement source with chelating agents, hydrazine, cobra venom factor, specific antisera to C1q, CR, C5, C6, or C8, or by heating at 56 degrees C for 30 min. Purified radiolabeled C4, C3, and C8 included in the complement source were bound to hemolysed SRC in direct proportion to the degree of hemolysis. These data indicate that polyclonal IgM-RF fix and activate complement via the classic pathway. The system described for assessing complement fixation by isolated RF is readily adaptable to use with whole human serum.

Tanimoto, K; Cooper, N R; Johnson, J S; Vaughan, J H

1975-01-01

385

The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor  

Microsoft Academic Search

Blood coagulation is initiated when tissue factor binds to coagulation factor Vila to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined the crystal structure at 2.0-Å resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor. In the complex, factor VIIa adopts

David W. Banner; Allan D'Arcy; Christiana Chène; Fritz K. Winkler; Arabinda Guha; William H. Konigsberg; Yale Nemerson; Daniel Kirchhofer

1996-01-01

386

External factors in the development of cataract  

Microsoft Academic Search

AimsTo provide an update on the risk factors for cataract development.MethodsReview of the literature.ResultsAge and heredity are the most important risk factors associated with the different types of cataract. While the hereditary component is self-explanatory, increasing age serves as a surrogate for a number of potential external risk factors, the effect of which is cumulative. Identification of the risk factors

L Robman; H Taylor

2005-01-01

387

Secreted Growth Factors as Therapeutic Targets  

Microsoft Academic Search

\\u000a Secreted growth factors directed from malignant cell to malignant cell, malignant cell to stromal cells, vascular cells and\\u000a immune system cells or from stromal cells, vascular cells and immune system cells to malignant cells are essential for the\\u000a growth and progression of malignant disease. Proangiogenic factors including members of the vascular endothelial growth factor\\u000a (VEGF)-A family, placental growth factor, members

Beverly A. Teicher

388

ILUT: A dual threshold incomplete LU factorization  

Microsoft Academic Search

In this paper we describe an Incomplete LU factorization technique basedon a strategy which combines two heuristics. This ILUT factorization extendsthe usual ILU(0) factorization without using the concept of level offill-in. There are two traditional ways of developing incomplete factorizationpreconditioners. The first uses a symbolic factorization approach in which alevel of fill is attributed to each fill-in element using only

Yousef Saad

1994-01-01

389

Kruppel-like factors in lymphocyte biology  

PubMed Central

The Krüppel-like factor (KLF) family of transcription factors plays an important role in differentiation, function and homeostasis of many cell types. While their role in lymphocytes is still being determined, it is clear that these factors influence processes as varied as lymphocyte quiescence, trafficking, differentiation and function. This review will present an overview of how these factors operate and coordinate with each other in lymphocyte regulation.

Hart, Geoffrey T.; Hogquist, Kristin A.; Jameson, Stephen C.

2011-01-01

390

Blood coagulation factor VIII: An overview  

Microsoft Academic Search

Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by\\u000a factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights\\u000a current knowledge on selected aspects of FVIII in which both the scientist and the clinician should be interested.

G. M. Bhopale; R. K. Nanda

2003-01-01

391

Factoring Differences for Iterative Change Management  

Microsoft Academic Search

An approach for factoring source-code differences is presented. A single large difference between two versions of a program is decomposed into factors (i.e., smaller changes). The application of all the factors is equivalent to the application of the single large difference. The factors are obtained by user-defined criteria. They include changes that are limited to a specific syntactic construct or

Michael L. Collard; Huzefa H. Kagdi; Jonathan I. Maletic

2006-01-01

392

Universal risk factors for multifactorial diseases  

Microsoft Academic Search

The risk for multifactorial diseases is determined by risk factors that frequently apply across disorders (universal risk\\u000a factors). To investigate unresolved issues on etiology of and individual’s susceptibility to multifactorial diseases, research\\u000a focus should shift from single determinant-outcome relations to effect modification of universal risk factors. We present\\u000a a model to investigate universal risk factors of multifactorial diseases, based on

Ronald P. Stolk; Judith G. M. Rosmalen; Dirkje S. Postma; Rudolf A. de Boer; Gerjan Navis; Joris P. J. Slaets; Johan Ormel; Bruce H. R. Wolffenbuttel

2008-01-01

393

Measurement Bias Detection through Factor Analysis  

ERIC Educational Resources Information Center

|Measurement bias is defined as a violation of measurement invariance, which can be investigated through multigroup factor analysis (MGFA), by testing across-group differences in intercepts (uniform bias) and factor loadings (nonuniform bias). Restricted factor analysis (RFA) can also be used to detect measurement bias. To also enable nonuniform…

Barendse, M. T.; Oort, F. J.; Werner, C. S.; Ligtvoet, R.; Schermelleh-Engel, K.

2012-01-01

394

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

395

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

396

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

397

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

398

Cellular signaling by fibroblast growth factor receptors  

Microsoft Academic Search

The 22 members of the fibroblast growth factor (FGF) family of growth factors mediate their cellular responses by binding to and activating the different isoforms encoded by the four receptor tyrosine kinases (RTKs) designated FGFR1, FGFR2, FGFR3 and FGFR4. Unlike other growth factors, FGFs act in concert with heparin or heparan sulfate proteoglycan (HSPG) to activate FGFRs and to induce

V. P. Eswarakumar; I. Lax; J. Schlessinger

2005-01-01

399

Factors Explaining Faculty Technology Use and Productivity  

ERIC Educational Resources Information Center

|This study examines factors related to technology use in teaching by university faculty. An EFA analysis of multiple questions of technology use in the classroom found two factors: one loaded with Web use and the second with email use. Therefore, three research questions were asked: What factors explain faculty use of the Web or email? Are these…

Xu, Yonghong; Meyer, Katrina A.

2007-01-01

400

TCF transcription factors: molecular switches in carcinogenesis  

Microsoft Academic Search

Although originally cloned as lymphoid transcription factors, members of the T-cell factor (Tcf) family are now well recognized as key activators\\/repressors in many developmental processes. Transcriptionally inert Tcf factors become potent transactivators upon interaction with the Wnt signaling product ?-catenin or its Drosophila counterpart Armadillo. In contrast, Tcf proteins mediate repression when bound to members of the Groucho family of

Jeroen Roose; Hans Clevers

1999-01-01

401

A multiple factor analysis of advertising readership  

Microsoft Academic Search

34 advertising variables were defined, measured, and correlated with readership scores for 137 advertisements in the Feb., 1950 issue of the American Builder Criteria were obtained from the Advertising Research Foundations's Continuing Studies of business magazine readership. 2 factors were found to have major loadings on Readership. They were a Pictorial-Color factor and a Size factor. They accounted for 53%

Dik Warren Twedt

1952-01-01

402

Verifiable Partial Sharing of Integer Factors  

Microsoft Academic Search

It is not known to date how to partially share the factors of an integer (e.g., an RSA modulus) with verifiability. We construct\\u000a such a scheme on exploitation of a significantly lowered complexity for factoring n = pq using a non-trivial factor of ?(n).

Wenbo Mao

403

Precipitating factors of readmission of psychiatric patients  

Microsoft Academic Search

Responses to an interview guide by 100 mentally ill patients suggested that vocational, social, and self factors, respectively, were precipitating factors in the rehospitalization process. The results suggested the respondents' realistic viewpoints regarding the significance of employment, but a nonrealistic viewpoint about the significance of self. A profile emerged indicating those precipitating factors most likely associated with the rehospitalized mental

Peter O. Peretti

1974-01-01

404

A linear displacement power factor compensator  

Microsoft Academic Search

Nowadays, the consumer of energy has the concern in operating with a value of power factor inside of a value stipulated by the energy concessionaries. It is know that the power factor is related with the displacement power factor and the total harmonic distortion. The present work has as main objective the development and implementation of a linear compensator of

J. V. R. Nunes; R. A. M. Braga; F. B. Libano; S. L. Muller

2004-01-01

405

Factors Impacting the Child with Behavioral Inhibition  

ERIC Educational Resources Information Center

Various factors influence the developmental course of the behaviorally inhibited child. These factors include reciprocating, contextual factors, such as the child's own traits, the environment, the maternal characteristics, and the environment. Behaviorally inhibited children show physiological and behavioral signs of fear and anxiety when…

Hornbuckle, Suzanne R.

2010-01-01

406

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2010 CFR

...2009-01-01 2009-01-01 false Human factors. 460.15 Section 460.15...Reentry with Crew § 460.15 Human factors. An operator must take the precautions necessary to account for human factors that can affect a crew's...

2009-01-01

407

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Human factors. 460.15 Section 460.15...Reentry with Crew § 460.15 Human factors. An operator must take the precautions necessary to account for human factors that can affect a crew's...

2010-01-01

408

Hierarchical Factoring in a Standardized Achievement Battery.  

ERIC Educational Resources Information Center

The factorial validity of the Iowa Tests of Basic Skills was investigated. Hierarchical factor analysis was performed with a subset of the standardization data to explore the presence of second-order group factors. Results supported the construct validity of Language and Mathematics subscales. Verbal and Visual Information group factors were…

Martin, David J.; Dunbar, Stephen B.

1985-01-01

409

Configurations of Common Childhood Psychosocial Risk Factors  

ERIC Educational Resources Information Center

|Background: Co-occurrence of psychosocial risk factors is commonplace, but little is known about psychiatrically-predictive configurations of psychosocial risk factors. Methods: Latent class analysis (LCA) was applied to 17 putative psychosocial risk factors in a representative population sample of 920 children ages 9 to 17. The resultant class…

Copeland, William; Shanahan, Lilly; Costello, E. Jane; Angold, Adrian

2009-01-01

410

Risk Factors for Vascular Disease and Dementia  

Microsoft Academic Search

There is increasing evidence that risk factors for vascular disease and stroke are associated with cognitive impairment and Alzheimer’s disease. This paper reviews current knowledge on the relationship between risk factors for stroke and Alzheimer’s disease. The focus will be on ‘classical’ risk factors, including age and gender, socioeconomic status, diabetes, cholesterol, prior cardiovascular disease, atrial fibrillation, cigarette smoking and

Monique M. B. Breteler; Michiel L. Bots; Alewijn Ott; Albert Hofman

1998-01-01

411

Critical factors and performance measures of TQM  

Microsoft Academic Search

The aim of this study is to identify and interpret the critical factors and performance measures of TQM. Based on extensive review of prescriptive, conceptual, practitioner, and empirical literature; we were able to identify seven critical factors and more than 45 performance measures of TQM. A possible sequence for implementation of these factors is then presented.

Jaideep Motwani

2001-01-01

412

Risk Factor Monitoring & Methods - Areas of Research  

Cancer.gov

The Risk Factor Monitoring and Methods Branch examines individual and societal risk factors that affect the cancer burden. Working collaboratively with representatives from government and academia, we monitor these factors among the population and develop tools and techniques to improve methods of assessment.

413

Expression of Growth Factors in Dictyostelium discoideum  

Microsoft Academic Search

Growth factors and their binding proteins are important proteins regulating mammalian cell proliferation and differentiation so there is considerable interest in producing them as recombinant proteins, especially in hosts that do not already produce a complex mixture of growth factors. Many growth factors require post- translational modifications making them unsuitable for production in Escherichia coli or other prokaryotes. Since several

Sassan Asgari; Sharmila Arun; Martin B. Slade; John Marshall; Keith L. Williams; John F. Wheldrake

414

Meeting recommendations for multiple healthy lifestyle factors  

Microsoft Academic Search

BackgroundWhereas much is known about single lifestyle-related health risk factor prevalence and covariates, more research is needed to elucidate the interactions among multiple healthy lifestyle factors and variables that may predict adherence to these factors. Such data may guide both clinical and health policy decision making and person-centered approaches to population health improvement.

Nicolaas P. Pronk; Louise H. Anderson; A. Lauren Crain; Brian C. Martinson; Patrick J. O'Connor; Nancy E. Sherwood; Robin R. Whitebird

2004-01-01

415

Factorization Using the Quadratic Sieve Algorithm  

Microsoft Academic Search

Since the cryptosecurity of the RSA two key cryptoalgorithm is no greater than the difficulty of factoring the modulus (product of two secret primes), a code that implements the Quadratic Sieve factorization algorithm on the CRAY I computer has been developed at the Sandia National Laboratories to determine as sharply as possible the current state-of-the-art in factoring. Because all viable

James A. Davis; Diane B. Holdridge

1983-01-01

416

Accelerating, maintaining and sanctionanting factors of inflation  

Microsoft Academic Search

In order to understand inflation or stagflation in present day oligopolistic capitalism, it is necessary to distinguish the accelerating, the maintaining and the sanctionating factors of inflation. Four are the accelerating factors: change in profit margins, change in real wages above (or below) productivity, changes in the real exchange rate and in the costs of imports. The basic maintaining factors

LUIZ CARLOS BRESSER-PEREIRA; YOSHIAKI NAKANO

1984-01-01

417

The Factor Game (i-Math Investigations)  

NSDL National Science Digital Library

An online, interactive, multimedia math investigation. The Factor Game engages students in a friendly contest in which winning strategies involve distinguishing between numbers with many factors and numbers with few factors. Students are then guided through an analysis of game strategies and introduced to the definitions of prime and composite numbers.

Forum, Math; Illuminations; National Council of Teachers of Mathematics (NCTM)

2001-01-01

418

THE FACTOR STRUCTURE OF STREET TREE ATTRIBUTES  

Microsoft Academic Search

A factor analysis of 816 householder evaluations of street trees showed a general benefits factor and discrete annoyance factors in such areas as ground disturbance, disease, reduced visibility, and debris from fallen tree parts. Benefits were more highly related than annoyances to overall satisfaction with the street tree. The findings have implications for management of street trees and for future

Robert Sommer; Barbara A. Sommer

1989-01-01

419

ESTIMATING UNCERTAINITIES IN FACTOR ANALYTIC MODELS  

EPA Science Inventory

When interpreting results from factor analytic models as used in receptor modeling, it is important to quantify the uncertainties in those results. For example, if the presence of a species on one of the factors is necessary to interpret the factor as originating from a certain ...

420

Growth factors and cytokines in wound healing.  

PubMed

Wound healing is an evolutionarily conserved, complex, multicellular process that, in skin, aims at barrier restoration. This process involves the coordinated efforts of several cell types including keratinocytes, fibroblasts, endothelial cells, macrophages, and platelets. The migration, infiltration, proliferation, and differentiation of these cells will culminate in an inflammatory response, the formation of new tissue and ultimately wound closure. This complex process is executed and regulated by an equally complex signaling network involving numerous growth factors, cytokines and chemokines. Of particular importance is the epidermal growth factor (EGF) family, transforming growth factor beta (TGF-beta) family, fibroblast growth factor (FGF) family, vascular endothelial growth factor (VEGF), granulocyte macrophage colony stimulating factor (GM-CSF), platelet-derived growth factor (PDGF), connective tissue growth factor (CTGF), interleukin (IL) family, and tumor necrosis factor-alpha family. Currently, patients are treated by three growth factors: PDGF-BB, bFGF, and GM-CSF. Only PDGF-BB has successfully completed randomized clinical trials in the Unites States. With gene therapy now in clinical trial and the discovery of biodegradable polymers, fibrin mesh, and human collagen serving as potential delivery systems other growth factors may soon be available to patients. This review will focus on the specific roles of these growth factors and cytokines during the wound healing process. PMID:19128254

Barrientos, Stephan; Stojadinovic, Olivera; Golinko, Michael S; Brem, Harold; Tomic-Canic, Marjana

421

Comparing Factor Structures of Adolescent Psychopathology  

ERIC Educational Resources Information Center

|Research on the structure of adolescent psychopathology can provide information on broad factors that underlie different forms of maladjustment in youths. Multiple studies from the literature on adult populations suggest that 2 factors, Internalizing and Externalizing, meaningfully comprise the factor structure of adult psychopathology (e.g.,…

Verona, Edelyn; Javdani, Shabnam; Sprague, Jenessa

2011-01-01

422

Genetic Risk Factors in Acute Coronary Disease  

Microsoft Academic Search

Objective: We investigate whether each of the following: HPA-1, Factor V Leiden, prothrombin gene variant and the methylene tetrahydrofolate reductase gene (MTHFR) mutation, are risk factors for acute coronary disease in Portuguese patients. Material and Methods: 100 blood donors and 52 patients with an established diagnosis of myocardial infarction or unstable angina were evaluated for genetic risk factors, by determining

F. Araújo; A. Santos; V. Araújo; I. Henriques; F. Monteiro; E. Meireles; I. Moreira; D. David; M. J. Maciel; L. M. Cunha-Ribeiro

1999-01-01

423

Genetic Factors in Drug Abuse and Dependence  

Microsoft Academic Search

STATEMENT OF THE PROBLEM The etiology of drug abuse\\/dependence is a complex interplay of psychosocial and biological factors. These factors include socioeconomic status, education, drug availability, peer pressure, childhood and adult comorbid psychiatric disorders, and specific mutant genes. The emphasis of this chapter is on the role that genetic factors play in an individual's vulnerability to drug abuse\\/dependence, henceforth simply

David E. Comings

424

Human factors: a necessary tool for industry  

SciTech Connect

The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

Starcher, K.O.

1984-03-09

425

AUTOSOMAL RECESSIVE DEFICIENCIES OF COAGULATION FACTORS  

Microsoft Academic Search

Deficiencies of coagulation factors that cause a bleeding disorder, other than factor VIII and factor IX, are inherited as autosomal recessive traits and are generally rare, with prevalence in the general population varying between 1 in 500 000 and 1 in 2 000 000. In the last few years, the number of patients with recessively transmitted coagulation deficiencies has increased

F. Peyvandi; R. Asselta; P. M. Mannucci

2001-01-01

426

EXPOSURE FACTORS HANDBOOK (1997 FINAL REPORT)  

EPA Science Inventory

The Exposure Factors Handbook provides a summary of the available statistical data on various factors used in assessing human exposure. This Handbook is addressed to exposure assessors inside the Agency as well as outside, who need to obtain data on standard factors to calculate ...

427

Success Factors in Developing New Business Services  

Microsoft Academic Search

What factors lead to success in the development of new businesses services? By synthesising the literature on new goods development and services marketing, the results of a major empirical investigation of new service development in the business-to-business services sector are reported. A set of factors that describe new service projects is identified and which factors are responsible for accomplishing different

Ulrike de Brentani

1991-01-01

428

Stress intensity factors in spot welds  

Microsoft Academic Search

This paper looks at stress intensity factors of cracks in resistance spot welded joints. Stress intensity factors have been used in the past to predict fatigue crack propagation life of resistance spot welds. However, the stress intensity factors from all previous work was based on assumed initial notch cracks at the nugget, parallel to the sheets. Physical evidence shows, however,

Ning Pan; Sheri D Sheppard

2002-01-01

429

Aceptabilidad a suplementos nutricios en mujeres embarazadas o lactando y niños menores de cinco años  

Microsoft Academic Search

Objective. The present study explores the acceptance and consumption of nutritional supplements that form part of a governmental program to support nutritionally vulnerable groups. Material and Methods. Pregnant and lactating women, and mothers of malnourished toddlers, infants and children were interviewed. Data were collected, after in- troduction with an interview guide with an open-ended for- mat, through face-to-face interviews conducted

Homero Martínez; Lourdes Campero; Guadalupe Rodríguez; Juan Rivera

1999-01-01

430

Ampliando (com todo o respeito...) o Modelo das Cinco Forças de Porter  

Microsoft Academic Search

This work approaches a very read and discussed issue - the Porter's Five Forces of Competitive Position Model (1980) - but tries to perform it in an original way, analyzing some matters not discussed by the famous author neither by the ones who have written about him. A bibliography review was developed in order to describe very shortly the Five

MARCO AURELIO; CARINO BOUZADA; JOSE GERALDO PEREIRA BARBOSA

1980-01-01

431

El caduceo como emblema de la medicina: un error de casi cinco siglos  

Microsoft Academic Search

The snake has been associated to healing arts since the ancient times, probably because its skin-change ability and to symbolize that sola dosis facit venenum. The Staff of Aesculapius and the caduceum derivate from worshipping the snake; it is undeniable that both mythological symbols originated from the Life Tree, which represents wisdom and immortality. The inaccuracy of adopting the caduceum

Feliciano Blanco Dávila; Hernán Ramírez Vel

432

The Aztec, Frida Kahlo, and Cinco de Mayo: Mexico in Children's Literature  

ERIC Educational Resources Information Center

|The authors provide an overview of children's books published in the United States during the last decade (2000-2010) that deal with Mexico and Mexican people. Suggested guidelines for selecting quality books and a list of award-winning titles are included as resources for teaching about Mexico. (Contains 2 tables and 4 figures.)|

Bauml, Michelle; Field, Sherry L.

2012-01-01

433

Optimizing neurotrophic factor combinations for neurite outgrowth  

NASA Astrophysics Data System (ADS)

Most neurotrophic factors are members of one of three families: the neurotrophins, the glial cell-line derived neurotrophic factor family ligands (GFLs) and the neuropoietic cytokines. Each family activates distinct but overlapping cellular pathways. Several studies have shown additive or synergistic interactions between neurotrophic factors from different families, though generally only a single combination has been studied. Because of possible interactions between the neurotrophic factors, the optimum concentration of a factor in a mixture may differ from the optimum when applied individually. Additionally, the effect of combinations of neurotrophic factors from each of the three families on neurite extension is unclear. This study examines the effects of several combinations of the neurotrophin nerve growth factor (NGF), the GFL glial cell-line derived neurotrophic factor (GDNF) and the neuropoietic cytokine ciliary neurotrophic factor (CNTF) on neurite outgrowth from young rat dorsal root ganglion (DRG) explants. The combination of 50 ng ml-1 NGF and 10 ng ml-1 of each GDNF and CNTF induced the highest level of neurite outgrowth at a 752 ± 53% increase over untreated DRGs and increased the longest neurite length to 2031 ± 97 µm compared to 916 ± 64 µm for untreated DRGs. The optimum concentrations of the three factors applied in combination corresponded to the optimum concentration of each factor when applied individually. These results indicate that the efficacy of future therapies for nerve repair would be enhanced by the controlled release of a combination of neurotrophins, GFLs and neuropoietic cytokines at higher concentrations than used in previous conduit designs.

Deister, C.; Schmidt, C. E.

2006-06-01

434

Carrageenans inhibit growth-factor binding.  

PubMed Central

Carrageenans, a family of polysulphated carbohydrates, inhibited binding of basic fibroblast growth factor (bFGF), transforming growth factor beta 1 (TGF beta 1) and platelet-derived growth factor (PDGF). iota-Carrageenan was the most potent bFGF antagonist (IC50 = 0.4 +/- 0.1 microgram/ml), kappa-carrageenan was the most potent PDGF antagonist (IC50 = 1.7 +/- 1.3 micrograms/ml) and lambda-carrageenan was the most potent TGF beta 1 antagonist (IC50 = 19 +/- 2 micrograms/ml). None of the carrageenans, at concentrations up to 200 micrograms/ml, inhibited binding of insulin-like growth factor 1 or transforming growth factor alpha. Carrageenans are selective growth-factor antagonists and have potential for the treatment of disorders associated with the over-production of certain growth factors.

Hoffman, R

1993-01-01

435

Factorization using the quadratic sieve algorithm  

SciTech Connect

Since the cryptosecurity of the RSA two key cryptoalgorithm is no greater than the difficulty of factoring the modulus (product of two secret primes), a code that implements the Quadratic Sieve factorization algorithm on the CRAY I computer has been developed at the Sandia National Laboratories to determine as sharply as possible the current state-of-the-art in factoring. Because all viable attacks on RSA thus far proposed are equivalent to factorization of the modulus, sharper bounds on the computational difficulty of factoring permit improved estimates for the size of RSA parameters needed for given levels of cryptosecurity. Analysis of the Quadratic Sieve indicates that it may be faster than any previously published general purpose algorithm for factoring large integers. The high speed of the CRAY I coupled with the capability of the CRAY to pipeline certain vectorized operations make this algorithm (and code) the front runner in current factoring techniques.

Davis, J.A.; Holdridge, D.B.

1983-12-01

436

Factorization using the quadratic sieve algorithm  

SciTech Connect

Since the cryptosecurity of the RSA two key cryptoalgorithm is no greater than the difficulty of factoring the modulus (product of two secret primes), a code that implements the Quadratic Sieve factorization algorithm on the CRAY I computer has been developed at the Sandia National Laboratories to determine as sharply as possible the current state-of-the-art in factoring. Because all viable attacks on RSA thus far proposed are equivalent to factorization of the modulus, sharper bounds on the computational difficulty of factoring permit improved estimates for the size of RSA parameters needed for given levels of cryptosecurity. Analysis of the Quadratic Sieve indicates that it may be faster than any previously published general purpose algorithm for factoring large integers. The high speed of the CRAY I coupled with the capability of the CRAY to pipeline certain vectorized operations make this algorithm (and code) the front runner in current factoring techniques.

Davis, J.A.; Holdridge, D.B.

1983-01-01

437

Factor tree (grades 6-8)  

NSDL National Science Digital Library

This virtual manipulative challenges the learner to find the prime factors for a pair of numbers. The factors for each number are displayed in a tree diagram from which the student drags the factors to the appropriate areas of a Venn diagram. The Venn diagram offers a useful visual display showing unique factors and common factors for the original pair of numbers. Using the display, the learner must find the pair's least common multiple (LCM) and greatest common factor (GCF). Buttons allow users to check their answers and select new problems. Instructions for using the manipulative are included, along with information about factoring. The site also links to the NCTM standard for number and operations. Copyright 2005 Eisenhower National Clearinghouse

Mathematics, Utah S.

2003-01-01

438

Future of coagulation factor replacement therapy.  

PubMed

Over a million patients worldwide currently suffer from hemophilia and other congenital clotting factor deficiencies. Patients affected with hemophilia A and B are treated by intravenous replacement therapy of factor VIII and factor IX, respectively. Current hemophilia treatments have favorably supported their efficacy, tolerability, and safety profiles. The onset of alloantibodies inactivating the infused coagulation factor is the main problem in hemophilia patients rendering replacement therapies ineffective; another disadvantage is the short half-life of the infused clotting factors with the need for multiple and frequent infusions to manage a bleeding episode. Now, the challenge in the management of hemophilia treatment is the prolongation of the half-life and reduction in the immunogenicity of recombinant clotting factors. The bioengineering strategies, previously applied successfully to other therapeutic proteins, encourage the current efforts to produce novel coagulation factors with more prolonged bioavailability, with increased potency and resistance to inactivation and potentially reduced immunogenicity. PMID:23809113

Peyvandi, F; Garagiola, I; Seregni, S

2013-06-01

439

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex  

SciTech Connect

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

2008-01-01

440

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex  

SciTech Connect

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

2008-06-03

441

Agouti regulates adipocyte transcription factors.  

PubMed

Agouti is a secreted paracrine factor that regulates pigmentation in hair follicle melanocytes. Several dominant mutations cause ectopic expression of agouti, resulting in a phenotype characterized by yellow fur, adult-onset obesity and diabetes, increased linear growth and skeletal mass, and increased susceptibility to tumors. Humans also produce agouti protein, but the highest levels of agouti in humans are found in adipose tissue. To mimic the human agouti expression pattern in mice, transgenic mice (aP2-agouti) that express agouti in adipose tissue were generated. The transgenic mice develop a mild form of obesity, and they are sensitized to the action of insulin. We correlated the levels of specific regulators of insulin signaling and adipocyte differentiation with these phenotypic changes in adipose tissue. Signal transducers and activators of transcription (STAT)1, STAT3, and peroxisome proliferator-activated receptor (PPAR)-gamma protein levels were elevated in the transgenic mice. Treatment of mature 3T3-L1 adipocytes recapitulated these effects. These data demonstrate that agouti has potent effects on adipose tissue. We hypothesize that agouti increases adiposity and promotes insulin sensitivity by acting directly on adipocytes via PPAR-gamma. PMID:11245612

Mynatt, R L; Stephens, J M

2001-04-01

442

[Genetic factors in myocardial infarction].  

PubMed

One of the main mechanisms of acute myocardial infarction (AMI) is plaque rupture or erosion followed by intraluminal thrombus formation and occlusion of the coronary arteries. Thus far, many underlying conditions or environmental factors, such as hypertension, diabetes, dyslipidemia, smoking or obesity, as well as a family history of coronary artery diseases have been identified as risks for the onset of AMI. These risks suggest that AMI occurs due to interactions between underlying conditions and multiple genetic susceptibilities. For this reason, many target gene-disease association studies have been performed with the recent introduction of genome-wide association studies (GWAS) that have further revealed new genetic susceptibilities for AMI. GWAS is a way to examine many common genetic variants in different individuals to see if any variant is associated with a trait in a case-control fashion, and typically focuses on associations between single-nucleotide polymorphisms (SNP) and traits. SNP on chromosome 9p21 is one of the robust susceptibility variants for AMI which has been identified by many GWAS. In this review, we overview the methodology of GWAS, introduce genetic variants identified by GWAS as those with susceptibility for AMI, and describe the foresight of using GWAS to investigate genetic susceptibility to AMI. PMID:23672096

Hara, Masahiko; Sakata, Yasuhiko; Sato, Hiroshi

2013-02-01

443

Impact factors in nursing journals.  

PubMed

Journal impact factors (IFs), a measure of citation frequency, are published annually in Journal Citation Reports (JCR). Journal IFs, although controversial because of the uses to which they have been put in academic arenas, remain a metric about which nurses should be informed. This paper discusses key issues in the controversy, explains how IFs are computed, and presents historical and 2009 IF data for nursing journals. The number of nursing journals indexed in JCR has grown from 35 in 2004 to 74 in 2009. The journals currently indexed are diverse in terms of focus (practice vs research), specialty areas, and country of publication. The median IF score for nursing journals (0.91 in 2009) is similar to that for several other health care categories. Given the controversies surrounding IFs, it may be useful for nurses to play a more active role in furthering the debate by undertaking research relating to IFs, including studies of how they affect nurses' scholarly pursuits and publication decisions. PMID:21256359

Polit, Denise F; Northam, Sally

444

Bioaccumulation factors for PCBs revisited.  

PubMed

Bioaccumulation factors (BAFs) for individual polychlorinated biphenyl (PCB) congeners in Barents Sea and White Sea marine calanoid copepods were 1-3 orders of magnitude higher than BAFs in the same species in Canadian and Alaskan Arctic Ocean areas, and in freshwater plankton (Lake Ontario) reported from the mid- to early 1980s. The present study reviews variability in PCB BAFs from the North American Great Lakes and the Arctic Ocean, and discusses possible explanations for the large variation among different studies. BAFs are higher in recent arctic marine and Great Lakes studies than previously reported, and they are at least 10 times higher than those predicted from the octanol-water partition coefficient (KOW). If the recent high BAFs are realistic, it means that earlier reported BAFs are too low. This is likely due to earlier erroneously high quantification of water PCB concentrations, and it implies that bioaccumulation in zooplankton is more efficient than previously assumed. Evidence is presented supporting that also trophic transfer and biomagnification of PCBs in zooplankton leads to BAFs well above those predicted by simple equilibrium partitioning. Overall, miss-measurement of water PCB concentrations and biomagnification contribute significantly to variability in BAFs for PCBs within and among studies. This large variability of BAFs for PCBs in zooplankton illustrated in the present study is of importance for future assessments of potential new bioaccumulative chemicals that rely on measured BAFs, such as the European Union Registration, Evaluation and Authorization of Chemicals program (REACH). PMID:16047789

Borgå, Katrine; Fisk, Aaron T; Hargrave, Barry; Hoekstra, Paul F; Swackhamer, Deborah; Muir, Derek C G

2005-06-15

445

Factors influencing alginate gel biocompatibility.  

PubMed

Alginate remains the most popular polymer used for cell encapsulation, yet its biocompatibility is inconsistent. Two commercially available alginates were compared, one with 71% guluronate (HiG), and the other with 44% (IntG). Both alginates were purified, and their purities were verified. After 2 days in the peritoneal cavity of C57BL/6J mice, barium (Ba)-gel and calcium (Ca)-gel beads of IntG alginate were clean, while host cells were adhered to beads of HiG alginate. IntG gel beads, however, showed fragmentation in vivo while HiG gel beads stayed firm. The physicochemical properties of the sodium alginates and their gels were thoroughly characterized. The intrinsic viscosity of IntG alginate was 2.5-fold higher than that of HiG alginate, suggesting a greater molecular mass. X-ray photoelectron spectroscopy indicated that both alginates were similar in elemental composition, including low levels of counterions in all gels. The wettabilities of the alginates and gels were also identical, as measured by contact angles of water on dry films. Ba-gel beads of HiG alginate resisted swelling and degradation when immersed in water, much more than the other gel beads. These results suggest that the main factors contributing to the biocompatibility of gels of purified alginate are the mannuronate/guluronate content and/or intrinsic viscosity. PMID:21523903

Tam, Susan K; Dusseault, Julie; Bilodeau, Stéphanie; Langlois, Geneviève; Hallé, Jean-Pierre; Yahia, L'Hocine

2011-04-26

446

Genetic Factors and Orofacial Clefting  

PubMed Central

Cleft lip with or without cleft palate is the most common facial birth defect and it is caused by a complex interaction between genetic and environmental factors. The purpose of this review is to provide an overview of the spectrum of the genetic causes for cleft lip and cleft palate using both syndromic and nonsyndromic forms of clefting as examples. Although the gene identification process for orofacial clefting in humans is in the early stages, the pace is rapidly accelerating. Recently, several genes have been identified that have a combined role in up to 20% of all clefts. While this is a significant step forward, it is apparent that additional cleft causing genes have yet to be identified. Ongoing human genome-wide linkage studies have identified regions in the genome that likely contain genes that when mutated cause orofacial clefting, including a major gene on chromosome 9 that is positive in multiple racial groups. Currently, efforts are focused to identify which genes are mutated in these regions. In addition, parallel studies are also evaluating genes involved in environmental pathways. Furthermore, statistical geneticists are developing new methods to characterize both gene-gene and gene-environment interactions to build better models for pathogenesis of this common birth defect. The ultimate goal of these studies is to provide knowledge for more accurate risk counseling and the development of preventive therapies.

Lidral, Andrew C.; Moreno, Lina M.; Bullard, Steven A.

2008-01-01

447

On the Likelihood Ratio Test for the Number of Factors in Exploratory Factor Analysis  

ERIC Educational Resources Information Center

|In the exploratory factor analysis, when the number of factors exceeds the true number of factors, the likelihood ratio test statistic no longer follows the chi-square distribution due to a problem of rank deficiency and nonidentifiability of model parameters. As a result, decisions regarding the number of factors may be incorrect. Several…

Hayashi, Kentaro; Bentler, Peter M.; Yuan, Ke-Hai

2007-01-01

448

Factor Structure and Invariance Across Gender of the Devereux Early Childhood Assessment Protective Factor Scale  

Microsoft Academic Search

Early childhood social–emotional assessment has traditionally focused on risk factors or psychopathology, and has less frequently examined protective factors that may serve to promote positive developmental outcomes for children. To advance conceptual models that include protective factors as key explanatory constructs, there is a need for quantitative measures of protective factors that are psychometrically sound and function similarly across different

Julia A. Ogg; Tara M. Brinkman; Robert F. Dedrick; John S. Carlson

2010-01-01

449

On z-factorization and c-factorization of standard episturmian words  

Microsoft Academic Search

Ziv-Lempel and Crochemore factorization are two kinds of factorizations of\\u000awords related to text processing. In this paper, we find these factorizations\\u000afor standard epiesturmian words. Thus the previously known c-factorization of\\u000astandard Sturmian words is provided as a special case. Moreover, the two\\u000afactorizations are compared.

M. Mohammad-Nooria; N. Ghareghanib; P. Sharifani

2010-01-01

450

The relationship between factor XI coagulant and factor XI antigenic activity in cattle.  

PubMed Central

Factor XI protein, isolated from normal bovine plasma, was used to raise antiserum in rabbits. The antisera was partially purified and used in a neutralization-inhibition assay to investigate the relationship between factor XI coagulant activity and antigenic material in the plasma of normal cattle and cattle homozygous and heterozygous for factor XI deficiency. Factor XI antigen was reduced in both the homozygous and heterozygous animals to levels comparable to the factor XI coagulant activity. The reduction of immunologically cross-reactive material to normal factor XI suggests that the factor XI coagulation defect is associated with the absence of a normal protein.

Gentry, P A

1984-01-01

451

Tuberculosis: distribution, risk factors, mortality.  

PubMed

About a century after Koch's discovery of the TB bacilli the tuberculosis epidemic which had appeared to be under control was again recognized as a major global health threat. The decline in the epidemic in this century had been largely through the improved living standards and, eventually, the availability and use of effective antibiotics. While tuberculosis gradually disappeared from the health agenda in the western world it remained a big killer throughout the century and in 1992 an estimated 2.7 million TB deaths occurred; 30 million will die from TB during the 1990s if current trends are not reversed. The annual number of new cases will increase from 7.5 million estimated in 1990 to more than 10 million in the year 2000. The main factors for this increase are demographic forces, population movements, the HIV epidemic and increasing drug resistance. The impact of the HIV epidemic is already felt in many sub-Saharan African countries and now threatens Asia where almost two-thirds of the world's TB infected population live and where HIV is spreading. Tuberculosis has also reemerged as a major public health problem in industrialized countries due to international migration, the breakdown of health services, including TB services etc. The control of the epidemic can only be through a concerted action to reinstate TB as priority among health concerns, reflected in national and international resources. A coalition of public and private supporters must be mobilized to support the effort to fight the disease. Governments, non-governmental organizations, the business community, refugee organizations, medical institutions, and other UN agencies are invited to join with WHO in this effort. PMID:7713546

Kochi, A

1994-10-01

452

[Psychosocial factors in duodenal ulcer].  

PubMed

"Burn-out" is a kind of assistential laboral stress which affects the professions which involve an interpersonal relationship with beneficiaries of the job, such us health workers. It originates emotional alterations which lead to feelings of emptiness and personal failure or laboral inability. The revisions about studies of mental disorders in health workers fall upon such laboral stress and remark that in such professional people there is a bigger prevalence of disorders because of the use of substances and of depression. To analyse the mental disorders in health workers by means of the retrospective study of a sample in a general hospital which asked for a psychiatric consultation, sociodemographic variables, clinico-diagnostic and variables related to laboral activity were analysed. The sample is constituted by 112 patients of an average age of forty years old and preferentially females (79.5%). In the sample, some professions are represented above all expectations; they are nurses, physicians, the laboral category of "boss and managers" and the laboral regimen of "permanents". The more frequent psychiatric disorders were the adjustment disorders and code V, the affective disorders and the anxiety disorders (23-33%), the disorders caused by the use of substances and the psychotic disorders are limited (5%). The laboral activity was considered an important factor in 43% of the cases and the mental disorder caused laboral inability, transitory or permanent in half of the patients. It is detected a relationship between the diagnostic and variables such as sex, laboral category, laboral inability, psychosocial stress level and GAF and there hasn't been detected any association between mental disorders and age, profession, laboral regimen and laboral stress. PMID:8079674

de la Gándara Martín, J J; de Dios Francos, A; de Diego Herrero, E; Goñi Labat, A I; Hernández Herrero, H; Pozo de Castro, J V

453

Sulfation of von Willebrand factor  

SciTech Connect

von Willebrand factor (vWF) is a multimeric adhesive glycoprotein essential for normal hemostasis. We have discovered that cultured human umbilical vein endothelial cells incorporate inorganic sulfate into vWF. Following immunoisolation and analysis by polyacrylamide or agarose gel electrophoresis, metabolically labeled vWF was found to have incorporated (35S)-sulfate into all secreted multimer species. The time course of incorporation shows that sulfation occurs late in the biosynthesis of vWF, near the point at which multimerization occurs. Quantitative analysis suggests the presence, on average, of one molecule of sulfate per mature vWF subunit. Virtually all the detectable sulfate is released from the mature vWF subunit by treatment with endoglycosidases that remove asparagine-linked carbohydrates. Sulfated carbohydrate was localized first to the N-terminal half of the mature subunit (amino acids 1 through 1,365) by partial proteolytic digestion with protease V8; and subsequently to a smaller fragment within this region (amino acids 273 through 511) by sequential digestions with protease V8 and trypsin. Thus, the carbohydrate at asparagine 384 and/or 468 appears to be the site of sulfate modification. Sodium chlorate, an inhibitor of adenosine triphosphate-sulfurylase, blocks sulfation of vWF without affecting either the ability of vWF to assemble into high molecular weight multimers or the ability of vWF multimers to enter Weible-Palade bodies. The stability of vWF multimers in the presence of an endothelial cell monolayer also was unaffected by the sulfation state. Additionally, we have found that the cleaved propeptide of vWF is sulfated on asparagine-linked carbohydrate.

Carew, J.A.; Browning, P.J.; Lynch, D.C. (Harvard Medical School, Boston, MA (USA))

1990-12-15

454

Male factor subfertility: possible causes and the impact of nutritional factors  

Microsoft Academic Search

Objective: To review possible causes for male factor subfertility with emphasis on nutritional factors such as zinc and folate.Design: A literature search was performed on MEDLINE and via bibliographies of published works.Result(s): Many causes for male factor subfertility are described in the literature. Both environmental and genetic factors could play a role. However, the pathogenesis of male factor infertility is

Wai Yee Wong; Chris M. G Thomas; Johannus M. W. M Merkus; Gerhard A Zielhuis; Régine P. M Steegers-Theunissen

2000-01-01

455

Functional consequences of the Ser334-->Pro mutation in a human factor X variant (factor XMarseille).  

PubMed

A factor X molecular variant was identified in a 55-year-old woman at a routine preoperative coagulation screening. Plasma factor X antigen was normal, whereas factor X activity was decreased when factor X was activated by either the extrinsic pathway (21%), the intrinsic pathway (21%) or the factor X activator from Russell viper venom, RVV-X (26%). Factor XMarseille was isolated from plasma by immunoaffinity chromatography and compared with normal factor X purified by the same method. Activation of factor XMarseille by factor IXa or by RVV-X in a purified system showed that the rate of cleavage was decreased, whereas once produced, factor XaMarseille had a normal catalytic efficiency for either the peptide substrate S-2765 (D-Arg-Gly-Arg-NH-Np) or prothrombin. The rate of inhibition of factor XaMarseille by antithrombin III was also normal. Defective proteolysis of factor XMarseille by factor IXa or by RVV-X was the consequence of a threefold decrease in the kcat for the activation of factor XMarseille while the Km of RVV-X or factor IXa for factor X was normal. We have determined the molecular basis of the defect in the factor XMarseille gene by amplification of all eight exons, single-strand conformational polymorphism analysis of the amplified exons and subsequent sequence analysis. The patient was homozygous for a T-->C mutation in exon VIII, resulting in the substitution of Ser334 by proline. From comparison of three-dimensional models of various serine proteases, it appears that Ser334 is located within a surface-exposed variable region of factor X. This observation suggests that the Ser334-->Pro mutation either is responsible for a misalignment of the active sites of specific factor X activators in close proximity to the cleavage site, or that the Ser-->Pro mutation alters the spatial orientation of the cleavage site by nonlocal modifications of factor X structure. PMID:8529633

Bezeaud, A; Miyata, T; Helley, D; Zeng, Y Z; Kato, H; Aillaud, M F; Juhan-Vague, I; Guillin, M C

1995-11-15

456

View factors between APT target components  

SciTech Connect

In a loss-of-coolant accident (LOCA) in the accelerator production of tritium (APT) target/blanket, radiation heat transfer determines the temperature of the target components. Radiation heat-transfer analysis can only proceed if accurate component-to-component view factors are available. The authors describe and demonstrate the numerical method used to compute the view factors (also called angle factors, configuration factors, and shape factors) between complicated objects. The method is verified on simple objects that have analytic solutions, and then it is used to predict the view factors between the target components of the accelerator production of tritium target/blanket. The method is practical, easy to apply, and can accommodate difficult levels of realism.

Kidman, R.B.

1998-07-01

457

Interactions between task repetition and psychosocial factors.  

PubMed

Psychosocial factors, individual factors, workplace requirements, and workplace organizational factors have all been reported as being associated with the risk of musculoskeletal disorders [11]. Huang, Feuerstein, and Sauter [5] described the various concepts and models proposed to link occupational stress and work-related upper extremity disorders, as well as the difficulty in verifying the suggested linkages. Huang et al. [5] suggested that decomposing a complex model would be an appropriate method to begin the investigations of the proposed models. Task repetition is a workplace requirement that is considered a potential risk factor for cumulative trauma and its relationship to psychosocial factors was investigated. The study found only weak to no statistically significant relationship between task repetition and reported psychosocial factors of job stress in workers in Taiwan. PMID:22317075

Riley, Michael W; Hung, Yu-Ting; Wang, Mao-Jiun; Lin, Yueh-Ling; Blunk, Jessica C

2012-01-01

458

Group factor analysis for Alzheimer's disease.  

PubMed

For any neuroimaging study in an institute, brain images are normally acquired from healthy controls and patients using a single track of protocol. Traditionally, the factor analysis procedure analyzes image data for healthy controls and patients either together or separately. The former unifies the factor pattern across subjects and the latter deals with measurement errors individually. This paper proposes a group factor analysis model for neuroimaging applications by assigning separate factor patterns to control and patient groups. The clinical diagnosis information is used for categorizing subjects into groups in the analysis procedure. The proposed method allows different groups of subjects to share a common covariance matrix of measurement errors. The empirical results show that the proposed method provides more reasonable factor scores and patterns and is more suitable for medical research based on image data as compared with the conventional factor analysis model. PMID:23533539

Cheng, Wei-Chen; Cheng, Philip E; Liou, Michelle

2013-03-05

459

Group Factor Analysis for Alzheimer's Disease  

PubMed Central

For any neuroimaging study in an institute, brain images are normally acquired from healthy controls and patients using a single track of protocol. Traditionally, the factor analysis procedure analyzes image data for healthy controls and patients either together or separately. The former unifies the factor pattern across subjects and the latter deals with measurement errors individually. This paper proposes a group factor analysis model for neuroimaging applications by assigning separate factor patterns to control and patient groups. The clinical diagnosis information is used for categorizing subjects into groups in the analysis procedure. The proposed method allows different groups of subjects to share a common covariance matrix of measurement errors. The empirical results show that the proposed method provides more reasonable factor scores and patterns and is more suitable for medical research based on image data as compared with the conventional factor analysis model.

Cheng, Philip E.; Liou, Michelle

2013-01-01

460

Roles for Growth Factors in Cancer Progression  

PubMed Central

Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy.

Witsch, Esther; Sela, Michael; Yarden, Yosef

2011-01-01

461

De la oportunidad del empleo formal al riesgo de exclusión laboral Desigualdades estructurales y dinámicas en los mercados latinoamericanos de trabajo  

Microsoft Academic Search

This article seeks to approach processes of inequality formation in labor markets. It also establishes a distinction between structural or historical inequalities, a legacy of the past modernization as well as dynamic inequalities as a result of global risk. Latin American labor markets are under profound processes of transformation. Formal employment is loosing up its centrality and various tendencies towards

JUAN PABLO PÉREZ SÁINZ; MORA SALAS

462

Manzana fresca cortada tratada con aditivos naturales: calidad y aspectos estructurales Fresh-cut apple treated with natural additives: quality and structural aspects  

Microsoft Academic Search

The effect of different natural additives on some quality parameters of fresh-cut Fuji apple is studied during 4 weeks of storage at 4°C. The results show that the calcium lactate maintains the texture and improves the structure of the fresh-cut apple during the storage. It strengthens the cell walls due to the formation of calcium pectates. The combination of cysteine

L. Alandes; A. Quiles; I. Pérez-Munuera; I. Hernando

2011-01-01

463

Factors affecting ostrich egg hatchability.  

PubMed

Ostrich eggs often have low hatchability (HATCH) rates because they do not lose sufficient weight during incubation. Because egg size, eggshell porosity and thickness (THICK), and length of preincubation egg storage are known to affect egg weight loss during incubation (EWL) and HATCH of chicken eggs, these factors were examined using ostrich eggs. The effects of eggshell porosity (number of large pores per cm2 of shell; LP); and THICK on EWL and HATCH were assessed by categorizing the eggs as having either low, intermediate, or high LP or low, intermediate, or high THICK. Mean EWL was higher (P<0.05) in eggs of the high LP group when compared with eggs in either the low or intermediate LP groups that lost similar amounts of weight during incubation. Mean HATCH was also higher (more than 25%; P<0.10) in eggs with high LP when compared with the HATCH found in eggs having low LP. Eggs from the intermediate LP group had an intermediate HATCH response. Moreover, numbers of LP were positively correlated to both EWL (r2 = 0.64; P<0.0001) and HATCH (r2 = 0.25; P<0.03). Inverse relationships existed between THICK and EWL and between THICK and HATCH according to the order (P< 0.05): eggs of low THICK, highest mean EWL and HATCH > eggs of intermediate THICK, intermediate mean EWL and HATCH > eggs of highest THICK, lowest mean EWL and HATCH. Shell thickness was not correlated to either EWL or HATCH. The influence of egg size on mean LP, THICK, EWL, HATCH, and chick weight (CWT) was assessed. Although THICK was unaffected by egg size, higher LP (P<0.10), EWL (P<0.05), and HATCH (P<0.10) were found in medium-sized eggs when compared with either small or large eggs. The CWT was associated with egg size (P<0.05) according to the order: large eggs, highest CWT > medium eggs, intermediate CWT > small eggs, lowest CWT. Neither EWL nor HATCH was affected by length of preincubation egg storage. Collectively, our findings suggest that 1) ostrich eggs that possess low LP and increased THICK hatched poorly, 2) intermediate-sized eggs hatch best, 3) large eggs produced large chicks, and 4) ostrich eggs can be stored under conditions typically used in the poultry industry for a minimum of 10 d without negatively impacting HATCH. PMID:10515354

Gonzalez, A; Satterlee, D G; Moharer, F; Cadd, G G

1999-09-01

464

Genetic engineering and coagulation factors.  

PubMed

It is unfortunate that we cannot report, in the area of coagulation, advances that have been seen in related fields such as thrombolytic therapy. The reported progress (Gold et al, 1984; Van de Werf et al, 1984) with human recombinant tissue plasminogen activator (Pennica et al, 1983) augers well for the application of recombinant technology to the problems faced by patients with coagulation defects. While plasminogen activator is being assessed in an acute therapeutic setting, its use signals a beginning of the application of the technology to abnormalities of the haemostatic mechanism. Chronic administration of coagulation factors for prophylaxis and replacement therapy would appear to be just one more step down the pathway illuminated by the biochemists, microbiologists and cell biologists who have preceded the clinicians in this promising area. There is no record of the use of genetically engineered materials in the treatment of coagulation defects, primarily because the body of knowledge and refined techniques have only recently been acquired. For this reason we have had to project developments in other areas onto the problems that exist for the haemostatically compromised patient. In describing the potential usefulness of these technologies, it is difficult to ascertain where the logical projection, from a fully investigated model system, diverges from flights of imaginative fancy. Cloning projects considered overly ambitious and grandiose at the beginning of this decade are already accomplished feats. The feasibility of gene therapy in the mammalian system has been demonstrated, and trade publications now discuss governmental approval for investigative use of this procedure in 1985. Panels of physicians, scientists and even politicians now seriously contemplate and promulgate views and regulations pertaining to the efficacy and ethics of the use of genetic engineering in the treatment of human disease. The haemophilias will certainly be among the first genetic diseases to be approached with the techniques of recombinant DNA technology. Diagnostic testing, using cloned DNA, is already underway and therapeutic trials are predicted for the near future. Every observer of this rapidly growing field has to define for himself when the future is. For the potential carrier of haemophilia B, the future is now. For the physician managing the patient with a haemophilic inhibitor, the future can't come soon enough. And, for those who are concerned with man's tampering with the gene pools of living things, from viruses to humans, the future comes too quickly to be dealt with in a rational and understanding way. PMID:3930118

Fass, D N; Toole, J J

1985-06-01

465

Risk factors for osteoporosis in healthy males  

Microsoft Academic Search

We investigated the correlation of bone mineral density (BMD) with risk factors and laboratory parameters (e.g., markers of\\u000a bone turnover, biochemical indicators, and hormonal factors) in males without secondary osteoporosis. A total of 105 males\\u000a were divided into two groups: Group 1 (n: 52) <60 years, and Group 2 (n:53) ? 60 years. The subjects were evaluated for risk\\u000a factors

Özlem Seven; Hale Karapolat; Sibel Eyigor; Yesim Kirazl?; Berrin Durmaz

2010-01-01

466

Risk factors for depressive symptoms during pregnancy  

Microsoft Academic Search

The present study examined risk factors for depression during pregnancy in a very large population sample. Two research questions\\u000a have been addressed: first, the association between demographic factors and past negative obstetrical outcomes on depression\\u000a severity scores, and second, the differences in these factors between women recruited at a university medical center and maternal\\u000a health centers (MHC). The study included

Hristina Koleva; Scott Stuart; Michael W. O’Hara; Jennifer Bowman-Reif

2011-01-01

467

Erosion—diagnosis and risk factors  

Microsoft Academic Search

Dental erosion is a multifactorial condition: The interplay of chemical, biological and behavioural factors is crucial and\\u000a helps explain why some individuals exhibit more erosion than others. The erosive potential of erosive agents like acidic drinks\\u000a or foodstuffs depends on chemical factors, e.g. pH, titratable acidity, mineral content, clearance on tooth surface and on\\u000a its calcium-chelation properties. Biological factors such

A. Lussi; T. Jaeggi

2008-01-01

468

Stress fractures: Pathophysiology, epidemiology, and risk factors  

Microsoft Academic Search

A stress fracture represents the inability of the skeleton to withstand repetitive bouts of mechanical loading, which results\\u000a in structural fatigue and resultant signs and symptoms of localized pain and tenderness. To prevent stress fractures, an appreciation\\u000a of their risk factors is required. These are typically grouped into extrinsic and intrinsic risk factors. Extrinsic risk factors\\u000a for stress fractures are

Stuart J. Warden; David B. Burr; Peter D. Brukner

2006-01-01

469

Nonnegative Matrix Factorization with Gaussian Process Priors  

PubMed Central

We present a general method for including prior knowledge in a nonnegative matrix factorization (NMF), based on Gaussian process priors. We assume that the nonnegative factors in the NMF are linked by a strictly increasing function to an underlying Gaussian process specified by its covariance function. This allows us to find NMF decompositions that agree with our prior knowledge of the distribution of the factors, such as sparseness, smoothness, and symmetries. The method is demonstrated with an example from chemical shift brain imaging.

Schmidt, Mikkel N.; Laurberg, Hans

2008-01-01

470

The Sp-family of transcription factors  

Microsoft Academic Search

GC-boxes and related motifs are frequently occurring DNA-elements present in many promoters and enhancers. In contrast to other elements it was generally thought that the transcription factor Sp1 is the only factor acting through these motifs. The cloning of paralogous genes of the Sp1 factor uncovered the existence of a small protein family consisting of Sp1, Sp2, Sp3 and Sp4.

G. Suske

1999-01-01

471

Full-Information Item Factor Analysis  

Microsoft Academic Search

A method of item factor analysis based on Thur stone's multiple-factor model and implemented by marginal maximum likelihood estimation and the EM algorithm is described. Statistical significance of suc cessive factors added to the model is tested by the likelihood ratio criterion. Provisions for effects of guessing on multiple-choice items, and for omitted and not-reached items, are included. Bayes constraints

R. Darrell Bock; Robert Gibbons; Eiji Muraki

1988-01-01

472

Instantaneous power factor determined by instantaneous phasors  

SciTech Connect

The instantaneous power factor can be clearly understood from the instantaneous phasors. The unique property of instantaneous phasors is that at any instant the instantaneous three-phase currents and voltages can be represented by a set of balanced phasors. The instantaneous power factor resembles the familiar format of power factor derived from the conventional phasors. This new concept can be used for power quality monitoring, diagnostics, and compensations.

Hsu, J.S.

1998-03-01

473

Environmental Factors in the Polycystic Ovary Syndrome  

Microsoft Academic Search

Polycystic ovary syndrome (PCOS) is a prevalent disorder that is still not well understood. Genetic predisposition is important,\\u000a but neonatal, prepubertal, pubertal, and postpubertal factors participate in its clinical expression. In this chapter we will\\u000a review these factors and the evidence that supports causal association with the development of PCOS. Unfortunately, little\\u000a evidence exists for many of these factors. Obesity

Marie-France Hivert; Jean-Patrice Baillargeon

474

The dressing factor and crossing equations  

Microsoft Academic Search

We utilize the DHM integral representation for the BES dressing factor of the world-sheet S-matrix of the AdS5 × S5 light-cone string theory, and the crossing equations to fix the principal branch of the dressing factor on the rapidity torus. The results obtained are further used, in conjunction with the fusion procedure, to determine the bound state dressing factor of

Gleb Arutyunov; Sergey Frolov

2009-01-01

475

Human factors and operating room safety.  

PubMed

A human factors model is used to highlight the nature of many systems factors that affect surgical performance, including the OR environment, teamwork and communication, technology and equipment, tasks and workload factors, and organizational variables. If further improvements in the success rate and reliability of cardiac surgery are to be realized, interventions need to be developed to reduce the negative impact that work system failures can have on surgical performance. Some recommendations are proposed here; however, several challenges remain. PMID:22269258

ElBardissi, Andrew W; Sundt, Thoralf M

2011-12-27

476

Human Monocytes Support Factor X Activation by Factor VIIa, Independent of Tissue Factor: Implications for the Therapeutic Mechanism of High-Dose Factor VIIa in Hemophilia  

Microsoft Academic Search

bosis to complicate its use. These complications are seen when preparations of the activated vitamin-K-dependent coagulation proteins, such as Autoplex, are used to treat pa- tients with inhibitors. High-dose factor VIIa therapy has not shown a propensity to initiate DIC or thrombosis in clinical trial^.^ Factor VIIa can activate factor X in vitro in the pres- ence of phospholipid vesicles

Maureane Hoffman; Dougald M. Monroe; Harold R. Roberts

1994-01-01

477

Factorization of the tenth Fermat number  

Microsoft Academic Search

We describe the complete factorization of the tenth Fermat num- ber F10 by the elliptic curve method (ECM). F10 is a product of four prime factors with 8, 10, 40 and 252 decimal digits. The 40-digit factor was found after about 140 Mflop-years of computation. We also discuss the complete fac- torization of other Fermat numbers by ECM, and summarize

Richard P. Brent

1999-01-01

478

Design and Synthesis of Binding Growth Factors  

PubMed Central

Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches.

Tada, Seiichi; Kitajima, Takashi; Ito, Yoshihiro

2012-01-01

479

Factorization and high-energy effective action  

SciTech Connect

I demonstrate that the amplitude for high-energy scattering can be factorized as a convolution of the contributions due to fast and slow fields. The fast and slow fields interact by means of Wilson-line operators{emdash}infinite gauge factors ordered along the straight line. The resulting factorization formula gives a starting point for a new approach to the effective action for high-energy scattering in QCD. {copyright} {ital 1999} {ital The American Physical Society}

Balitsky, I. [Physics Department, Old Dominion University, Norfolk, Virginia 23529 (United States)]|[Theory Group, Jefferson Lab, Newport News, Virginia 23606 (United States)

1999-07-01

480

Production and properties of monoclonal antibodies to human blood coagulation factor VII and factor VIIa  

SciTech Connect

Human factor VII is a trace vitamin K-dependent protein that circulates in blood as a single-chain precursor to a serine protease. Upon activation, two-chain factor VIIa activates factor x in the presence of tissue factor and calcium. Purified preparations of single-chain (SC) human factor VII and two-chain (TC) factor VIIa were utilized to immunize Balb/c mice. Spleen cells from these immunized mice were fused to a non-secreting NS-1 derivative of X63-Ag8 myeloma cells and grown in selective medium. Analysis of culture supernatants by EIA revealed several hybridomas that were secreting IgG specific for Sc-factor VII and TC-factor VIIa. In addition, several hybridomas secreted IgG that reacted equally well with factor VII and factor VIIa. One of the latter McAb (A-29) reacted with the heavy chain of factor VIIa and the intact factor VII molecule equally as judged by Western blotting. A-29 was produced in ascites fluid, purified and coupled to activated CH-Sepharose. Application of one liter of normal human plasma to 10 ml of this immunoadsorbent column, elution of factor VII and subsequent Western blot using /sup 125/I-rabbit anti-human factor VII indicated a single species of factor VII(M/sub r/ = 50 KDa) in normal plasma. These specific factor VII/VIIa McAbs may prove useful in the analysis of these factors, and in the separation of SC-factor VII from TC-factor VIIa.

Mann, P.; Nesbitt, J.A.; Ge, M.; Kisiel, W.

1986-03-05

481

Proteomic methodologies to study transcription factor function  

PubMed Central

Transcription factors regulate transcription by binding to regulatory regions of genes including the promoter. Few of the transcription factors are well characterized and few promoters have been described in detail. New methods have been developed to improve both transcription factor and promoter characterization, some of which are discussed here. Trapping methodology applicable to both individual transcription factors and intact transcription complexes are described, as well as 2-dimensional gel electrophoresis, Southwestern blotting, and basic liquid chromatography/tandem mass spectrometry methodology. These methods have proved useful in the study of transcriptional regulation.

Jarrett, Harry W.

2012-01-01

482

A Two-Factor Model of Temperament  

PubMed Central

The higher order structure of temperament was examined in two studies using the Adult Temperament Questionnaire. Because previous research showed robust levels of convergence between Rothbart’s constructs of temperament and the Big Five factors, we hypothesized a higher order two-factor model of temperament based on Digman’s higher order two-factor model of personality traits derived from factor analysis of the Big Five factors. Study 1 included 258 undergraduates. Digman’s model did not fit the data well, so we conducted an exploratory two-factor solution. One factor included extraversion/positive emotionality, orienting sensitivity, and affiliativeness, and the other, negative affect versus effortful control content. This two-factor model of temperament model diverged from the Digman model only on the agreeableness-affiliativeness loadings. Study 2 involved a community sample of 700 participants. Confirmatory factor analysis supported the alternative model found in Study 1. Findings are discussed in relation to research on attention and emotion.

Evans, David E.; Rothbart, Mary K.

2009-01-01

483

Characterization of groundwater contamination using factor analysis  

NASA Astrophysics Data System (ADS)

The effluent contamination of groundwater at two industrial sites at Visakhapatnam, India, was studied using factor analysis. Thirty groundwater samples near a zinc smelter plant and 19 from the polymers plant were analyzed for specific conductance, chloride, bicarbonate, sulfate, calcium, magnesium, sodium, and potassium. The data were subjected to R-mode factor analysis and the factor scores transferred to areal maps. While magnesium and sulfate are the dominant contaminants at the zinc site, sodium, chloride, and bicarbonate from the effluent are affecting groundwater in the polymers area. Contour maps for each factor suggest the areal extension of the contaminants.

Subbarao, C.; Subbarao, N. V.; Chandu, S. N.

1996-12-01

484

Growth factor transgenes interactively regulate articular chondrocytes.  

PubMed

Adult articular chondrocytes lack an effective repair response to correct damage from injury or osteoarthritis. Polypeptide growth factors that stimulate articular chondrocyte proliferation and cartilage matrix synthesis may augment this response. Gene transfer is a promising approach to delivering such factors. Multiple growth factor genes regulate these cell functions, but multiple growth factor gene transfer remains unexplored. We tested the hypothesis that multiple growth factor gene transfer selectively modulates articular chondrocyte proliferation and matrix synthesis. We tested the hypothesis by delivering combinations of the transgenes encoding insulin-like growth factor I (IGF-I), fibroblast growth factor-2 (FGF-2), transforming growth factor beta1 (TGF-?1), bone morphogenetic protein-2 (BMP-2), and bone morphogenetic protien-7 (BMP-7) to articular chondrocytes and measured changes in the production of DNA, glycosaminoglycan, and collagen. The transgenes differentially regulated all these chondrocyte activities. In concert, the transgenes interacted to generate widely divergent responses from the cells. These interactions ranged from inhibitory to synergistic. The transgene pair encoding IGF-I and FGF-2 maximized cell proliferation. The three-transgene group encoding IGF-I, BMP-2, and BMP-7 maximized matrix production and also optimized the balance between cell proliferation and matrix production. These data demonstrate an approach to articular chondrocyte regulation that may be tailored to stimulate specific cell functions, and suggest that certain growth factor gene combinations have potential value for cell-based articular cartilage repair. PMID:23097312

Shi, Shuiliang; Mercer, Scott; Eckert, George J; Trippel, Stephen B

2013-04-01

485

Tissue Factor; from Morawitz to Microparticles  

PubMed Central

Tissue factor is the principal activator of blood coagulation in vivo. The existence of extravascular tissue factor has been recognized for over a century, but a rational role as a cell-based enzymatic cofactor in blood coagulation was first proposed by Paul Morawitz in 1905. By the close of the last century, very low levels of circulating tissue factor had been identified in the intravascular compartment, but its role in health and in hemostatic and thrombotic disorders continues to be debated. Nonetheless, ongoing research suggests that tissue factor may be a rational therapeutic target in a number of human disease states.

Key, Nigel S.; Geng, Jian-Guo; Bach, Ronald R

2007-01-01

486

Important Drug Information - Antihemophilic Factor (Human) ...  

Center for Biologics Evaluation and Research (CBER)

... Important Drug Information - Antihemophilic Factor (Human), Koate DVI (3 lots)-Talecris Biotherapeutics. ... Food and Drug Administration. ... More results from www.fda.gov/biologicsbloodvaccines/safetyavailability/recalls

487

Characterization of the defect in activation of factor IX Chapel Hill by human factor XIa.  

PubMed Central

Factor IXChapel Hill (Factor IXCH), an abnormal Factor IX molecule isolated from the plasma of a patient with mild hemophilia B, has previously been shown to exhibit delayed activation by Factor XIa and calcium. In this study, we have found that Factor IXCH is cleaved upon incubation with human Factor XIa and calcium; however, cleavage of this protein is not observed by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis under nonreducing conditions. Under reducing conditions, the rate of disappearance of the zymogen parallels both the appearance of the heavy chain and the generation of clotting activity. In addition, a protein band that migrates with an apparent molecular weight of 45,000 also increases in parallel with clotting activity. Factor IXCH and normal Factor IX (Factor IXN), after incubation with Factor XIa and calcium, were subjected to amino terminal sequence analysis. Activated Factor IXN is cleaved at an arginine-alanine (Arg-Ala) bond and an arginine-valine (Arg-Val) bond as demonstrated by formation of the three amino terminal sequences corresponding to the amino terminal of the light chain, heavy chain, and activation peptide. However, activated Factor IXCH has only two amino terminal sequences, corresponding to the original amino terminal sequence and the heavy chain (formed by cleavage at the Arg-Val bond). It is concluded that the major defect in Factor IXCH is the inability of Factor XIa to cleave the Arg-Ala bond at a significant rate. The rate of formation of clotting activity of Factor IXCH is approximately 60% of the rate of formation of clotting activity of Factor IXN. The specific clotting activity of activated Factor IXCH is between 20 and 33% of activated Factor IXN. Images

Braunstein, K M; Noyes, C M; Griffith, M J; Lundblad, R L; Roberts, H R

1981-01-01

488

Tissue Factor: molecular recognition and cofactor function  

Microsoft Academic Search

One aspect of the inflammatory re- sponse is the activation of the coagulation protease cascade resulting from the expression of tissue factor (TF) on vascular cells. TF is the cell-surface receptor for the coagulation serine protease factor Vila, pro- viding cofactor function by \\

DAVID M. A. MARTIN; C. WILUAM G. BOYS

489

Adding emotional factors to synthesized voices  

Microsoft Academic Search

This paper deals with how to add emotional factors to synthesized voices by applying essentic forms of emotion which reflect the timewise response of muscle reaction to each kind of emotions. We modulate the magnitude and fundamental frequency of given series of voice with no emotional factor by the essentic standard forms obtained by fingertip pressure. Psychological evaluation of these

Fumio Hara

1997-01-01

490

Bisbenzamidine isoxazoline derivatives as factor Xa inhibitors  

Microsoft Academic Search

Factor Xa is an important serine protease in the blood coagulation cascade. It generates thrombin and holds the central position that links the intrinsic and extrinsic activation mechanism in the final common pathway of coagulation. Therefore, inhibition of factor Xa has potential therapeutic applications in the treatment of both arterial and venous thrombosis. We have designed and synthesized a series

M. L. Quan; J. R. Pruitt; C. D. Ellis; A. Y. Liauw; R. A. Galemmo; P. F. W. Stouten; J. Wityak; R. M. Knabb; M. J. Thoolen; P. C. Wong; R. R. Wexler

1997-01-01

491

Strangeness-changing scalar form factors  

Microsoft Academic Search

We derive expressions for strangeness-changing scalar form factors, which incorporate known theoretical constraints both at low and high energies. Their leading behaviour in the limit of a large number of colours is calculated from the resonance chiral Lagrangian, and a set of short-distance constraints on the scalar resonance couplings is obtained, imposing the form factors to vanish at infinite momentum

Matthias Jamin; Antonio Pich

2002-01-01

492

Functional dyspepsia: Are psychosocial factors of relevance?  

Microsoft Academic Search

The pathogenesis of Functional Dyspepsia (FD) remains unclear, appears diverse and is thus inadequately understood. Akin to other functional gastrointestinal disorders, research has demonstrated an association between this common diagnosis and psychosocial factors and psychiatric morbidity. Conceptualising the relevance of these factors within the syndrome of FD requires application of the biopsychosocial model of disease. Using this paradigm, dysregulation of

Sandra Barry; Timothy G Dinan

2006-01-01

493

Emotional factors in advertising via mobile phones  

Microsoft Academic Search

Advertising delivered via cell phones constitutes a promising approach to marketing because it enables easy targeting, content personalization, and interactive communication. We conducted a laboratory experiment with 48 participants using a 24-item structured questionnaire about important emotional components involved in using mobile phones for advertising. The data revealed three factors that explained 63% of the total variance. Factor 1 included

Gavriel Salvendy

2011-01-01

494

Emotional Factors in Advertising Via Mobile Phones  

Microsoft Academic Search

Advertising delivered via mobile phones constitutes a promising approach to marketing because it enables easy targeting, content personalization, and interactive communication. We conducted a laboratory experiment with 48 participants using a 24-item structured questionnaire about important emotional components involved in using mobile phones for advertising. The data revealed 3 factors that explained 63% of the total variance. Factor 1 included

Gavriel Salvendy

2012-01-01

495

Factors of Addiction: New Jersey Correctional Population  

ERIC Educational Resources Information Center

|Most state inmates incarcerated under the jurisdiction of the New Jersey Department of Corrections are driven to crimes by drug abuse. Understanding the factors contributing to addiction is the first step in developing strategies for successful inmate reintegration. This study presents an analysis of inmate addiction and factor association using…

Wojtowicz, James P.; Liu, Tongyin; Hedgpeth, G. Wayne

2007-01-01

496

[Tissue proliferation by thrombocyte growth factor].  

PubMed

An essay for determining the growth stimulating activity of human platelets has been established. With the aid of this system a mitogenic factor from crude platelet extract was isolated. Besides a stimulation of DNA-synthesis an enhanced synthesis of collagen and glycosaminoglycans is induced by the platelet growth factor. PMID:6510788

Dresow, B; Delbrück, A

1984-12-01

497

Scientific literacy: Factor structure and gender differences  

Microsoft Academic Search

The purpose of this study was to investigate the factor structure of scientific literacy and to document any gender differences with respect to each factor. Participants included 1139 students (574 females, 565 males) in grades 9 through 12 who were taking a science class at one of four Midwestern high schools. Based on National Science Education Standards, a 100 item

James Joseph Manhart

1997-01-01

498

Dimensions of female sexuality: A factor analysis  

Microsoft Academic Search

The present study was designed to generate hypotheses about dimensions underlying female sexuality. The subjects were 138 undergraduate women who completed three questionnaires about their sexual attitudes and behavior. A factor analysis yielded seven factors that were labeled as follows: (1) overall level of heterosexual activity; (2) level of noncoital heterosexual satisfaction; (3) gratification from masturbation; (4) responsivity to coital

deRosset Myers; Peter R. Kilmann; Richard L. Wanlass; Anna Stout

1983-01-01

499

Osteoporosis Risk Factors in Eighth Grade Students.  

ERIC Educational Resources Information Center

Presents findings from food frequency questionnaires and surveys of 138 Midwestern eighth-grade student-parent pairs. The study examined the incidence of modifiable and nonmodifiable osteoporosis risk factors and compared gender differences. Data analysis indicated that many adolescents possessed several modifiable and nonmodifiable risk factors

Lysen, Victoria C.; Walker, Robert

1997-01-01

500

Factors Underlying Tongue Articulation in Speech.  

ERIC Educational Resources Information Center

|Manipulation of speed of delivery and linguistic context followed by factor analysis of 11 measures of lingual activity involved in the production of the syllable /ka/ indicated three factors explained 75 percent of the variance: displacement/velocity, duration, and midsyllable duration and distance. (Author/DB)|

Keller, Eric

1987-01-01