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1

FACTORES DE INFLUENCIA EN LOS MECANISMOS DE FALLO DE ACEROS ESTRUCTURALES GALVANIZADOS  

Microsoft Academic Search

This paper shows the new achievements in the comprehension of failure mechanisms during hot-dip galvanizing of structural steels. The problem and its evolution are explained, and the last obtained results about factors that make easier the structural steels embrittlement during galvanization are shown. These results are the following: A decrease of the steel mechanical properties at 450ºC (galvanization temperature), the

J. Carpio; J. A. Casado; J. A. Álvarez; F. Gutiérrez-Solana

2007-01-01

2

FACTORES SOCIO-ESTRUCTURALES Y EL ESTIGMA HACIA EL VIH/SIDA: EXPERIENCIAS DE PUERTORRIQUEÑOS/AS CON VIH/SIDA AL ACCEDER SERVICIOS DE SALUD  

PubMed Central

RESUMEN El estigma relacionado al VIH/SIDA continúa afectando la prestación de servicios de salud y el bienestar físico y mental de las personas con VIH/SIDA (PVS). Recientemente la literatura científica ha señalado la importancia de comprender las manifestaciones de estigma más allá de las interacciones individuales. Por tal razón, investigaciones recientes en y fuera de Puerto Rico enfatizan la importancia de entender cómo factores socio-estructurales (FSE) influyen en los procesos de estigmatización social. Con el propósito de examinar los FSE que influyen en las manifestaciones de estigma relacionado al VIH/SIDA, realizamos y analizamos nueve grupos focales compuestos por hombres y mujeres en tratamiento para el VIH/SIDA que habían tenido experiencias estigmatizantes. Los participantes identificaron FSE relacionados a las manifestaciones de estigma, tales como el uso de viviendas especializadas, descentralización de los servicios de salud y el desarrollo de protocolos administrativos excluyentes en los servicios de salud. Los resultados demuestran la importancia de considerar los FSE en el desarrollo e implementación de intervenciones dirigidas a la población. PMID:24639599

RIVERA-DIAZ, MARINILDA; VARAS-DIAZ, NELSON; REYES-ESTRADA, MARCOS; SURO, BEATRIZ; CORIANO, DORALIS

2013-01-01

3

ESTIMACIN DE PARMETROS ESTRUCTURALES EN RISERS MARINOS UTILIZANDO FILTROS DE KALMAN  

E-print Network

ESTIMACI�N DE PARÁMETROS ESTRUCTURALES EN RISERS MARINOS UTILIZANDO FILTROS DE KALMAN EXTENDIDOS STRUCTURAL PARAMETER ESTIMATION IN MARINE RISERS USING EXTENDED KALMAN FILTERS LIZETH TORRES ORTIZ Instituto. Torres, C. Verde, O. Vázquez, "Parameter identification of marine risers using an extended Kalman filter

Boyer, Edmond

4

Factorize  

NSDL National Science Digital Library

Visualize factors through building rectangular areas on a grid. First enter all the factorizations of a number, then draw each factor set as an area on the grid. Factorize is one of the Interactivate assessment explorers.

5

Factoring  

NSDL National Science Digital Library

Test your factoring skills Factors and Multiples Jeopardy How much do you know about factoring and multiples? Play Jeopardy and find out! Prime Factoring Turkey Shoot Blast these turkeys using your factoring skills. Help the Professor Super save the planet by "cooking" the Giant Frozen Turkeys of Destruction. Math Lines 12 X-Factor Shoot the ball at the other factors to get a product of 12. You can also ...

Mr Clark

2012-10-31

6

Investigao em clulas estaminais no Biocant deu origem a cinco patentes em dois anos  

E-print Network

Investigação em células estaminais no Biocant deu origem a cinco patentes em dois anos, nos últimos dois anos, em cinco patentes, duas delas já licenciadas a empresas, disse à Lusa o vias de dar origem a um projeto empresarial" no âmbito do rastreio e criação de novos fármacos. As duas

Instituto de Sistemas e Robotica

7

Factorize  

NSDL National Science Digital Library

This interactive applet allows a student to visually explore the concept of factors by creating different rectangular arrays for a number. The user constructs the array by clicking and dragging on a grid. The length and width of the array are factors of the number. A student can elect an option of a randomly selected number or the student selects his own number between 2 and 50. Exploration questions are included to promote student discovery of mathematical concepts with factors.

2000-01-01

8

Factors  

NSDL National Science Digital Library

This lesson is designed to develop students' abilities to find factors of whole numbers. The lesson also introduces prime numbers. This lesson provides links to discussions and activities related to factors as well as suggested ways to integrate them into the lesson. Finally, the lesson provides links to follow-up lessons designed for use in succession with the current one. Note, reading level is not indicated because the lesson does not include student reading material.

2011-05-24

9

Factoring  

NSDL National Science Digital Library

In this lesson we will explore prime numbers and factors A prime number has only two factors, 1 and itself. The Greek scholar, Eratosthenes of Cyrene lived from approximately 275 to 195 BC. He is know for being the first to have computed the size of the Earth and served as the director of the famous library in

Mrs. Taylor

2010-10-19

10

Biologia floral, microsporogênese e número cromossômico em cinco espécies de plantas utilizadas na medicina popular no Rio Grande do Sul  

Microsoft Academic Search

RESUMO: Onze populações de cinco espécies de plantas medicinais utilizadas no Rio Grande do Sul, foram observadas quanto ao período de floração, durante três anos e estudadas citogeneticamente. Discaria americana e Matricharia chamomilla, florescem preferencialmente no inverno, Foeniculun vulgare e Symphytum officinale, nas estações mais quentes e Plectranthus barbatus floresce em estações mais amenas. Na meiose da microsporogênese, formaram-se 11

G. M. PEREIRA; DA SILVA

2006-01-01

11

CINCO RANCH is continuing  

E-print Network

-Clear Lake Postbaccalaureate Teacher Certification UH-Victoria Superintendent Certification UH-Victoria & Entrepreneurship* M.S. UH-Victoria Educational Management (Principalship and PDAS certification) M.S. UH-Clear Lake Instructional Technology* M.S. UH-Clear Lake Interdisciplinary Studies* M.A.I.S. UH-Victoria Mathematics* M

Azevedo, Ricardo

12

CARDIOPATÍAS CONGÉNITAS EN NIÑOS MENORES DE CINCO AÑOS. SERIE DE CASOS, 2003-2006: HOSPITAL REGIONAL, SANTANDER DE QUILICHAO, CAUCA, COLOMBIA  

Microsoft Academic Search

RESUMEN Este estudio descriptivo investiga las cardiopatías congénitas en menores de cinco años; se basó en una serie de casos consecutivos que consultaron o fueron remitidos a un hospital nivel dos en la región norte del departamento del Cauca, Colombia, entre el primero de julio de 2003 y el 31 de diciembre de 2005. Objetivo: Describir la situación actual con

Victor Hugo Rodríguez; Richard G. Shoemaker

13

Los Cinco Grandes across cultures and ethnic groups: Multitrait-multimethod analyses of the Big Five in Spanish and English  

Microsoft Academic Search

Spanish-language measures of the Big Five personality dimensions are needed for research on Hispanic minority populations. Three studies were conducted to evaluate a Spanish version of the Big Five Inventory (BFI)(O. P. John et al., 1991) and explore the generalizability of the Big Five factor structure in Latin cultural groups. In Study 1, a cross-cultural design was used to compare

Verónica Benet-Martínez; Oliver P. John

1998-01-01

14

Factor Trees  

NSDL National Science Digital Library

In this online activity, the learner finds the prime factorization of composite numbers by building factor trees. A second level includes finding the greatest common factor and the least common multiple by sorting factors using a Venn Diagram.

2010-01-01

15

Factor Trees  

NSDL National Science Digital Library

This virtual manipulative allows students to find the prime factorization of numbers by completing factor trees. Then they may use a venn diagram to sort the prime factors to find the greatest common factor and the least common multiple.

Math Playground

2009-07-29

16

Factoring with the Factor Tree  

NSDL National Science Digital Library

This Java applet presents a composite number, and prompts you to factor it -- one step at a time. Enter one factor, prime or another composite; the applet calculates the remaining factor, and branches two boxes below any composite factor so that you may proceed factoring until you obtain the full factorization into primes, which the applet colors in green. Click the "Repeat problem" button to see that different factor trees for a given number still result in the same prime factorization.

Interactive Math Miscellany and Puzzles, Alexander Bogomolny

2011-01-01

17

Factor Findings  

NSDL National Science Digital Library

In this lesson, students first create factor posters for a variety of different numbers that will be displayed in the classroom to be utilized as a resource throughout the school year. They make discoveries about factors using color tiles, represent their discoveries using graph paper, and display their information on poster board as find factors of an assigned number. The plan includes a list of materials, questions, assessment options, and extensions.

Jamie Piecora

2000-01-01

18

Factor Game  

NSDL National Science Digital Library

This is an interactive applet game exercises a student's factoring ability. A student can play against the computer or against a friend on grids containing the numbers 1-30, 1-49, or 1-100. Each player in turn chooses a number from the board, and then the opponent claims all of its remaining proper factors. A player's score is the sum of all the numbers and factors she/he has chosen. When there are no numbers remaining with unclaimed factors, the game ends and the player with the greater total is the winner.

Adapted with permission from "Prime Time: Factors and Multiples," Connected Mathematics Project, G. Lappan, J. Fey, W. Fitzgerald, S. Friel and E. Phillips

2000-01-01

19

Finding Factors  

NSDL National Science Digital Library

This lesson is designed to develop students' abilities to find factors of whole numbers. The lesson also introduces prime numbers. This lesson provides links to discussions and activities related to factors as well as suggested ways to integrate them into the lesson. Finally, the lesson provides links to follow-up lessons designed for use in succession with the current one.

2011-05-24

20

Factor Dazzle  

NSDL National Science Digital Library

This interactive online game helps students develop fluency with identifying factors while fostering strategic thinking. A student can play against the computer or against a friend on a 6 by 6 grid containing the numbers 1-36. Each player in turn chooses a number from the board, and then the opponent claims all of its remaining proper factors. A player's score is the sum of all the numbers and factors she/he has chosen. When there are no numbers remaining with unclaimed factors, the game ends and the player with the greater total is the winner. This game is part of NCTM's Calculation Nation project (cataloged separately). Users may login as a guest and play against the computer, or register (free) to challenge other players online.

2011-01-01

21

Rheumatoid Factor  

MedlinePLUS

... Formal name: Rheumatoid Factor Related tests: Cyclic Citrullinated Peptide Antibody , ANA , ESR , C-Reactive Protein , Autoantibodies At ... is negative and symptoms persist. A cyclic citrullinated peptide (CCP) antibody test can help diagnose RA in ...

22

Risk Factors  

MedlinePLUS

... Delicious Reddit StubmleUpon Print About Heart Disease & Stroke Risk Factors We're all at risk for heart ... are in the southeastern United States. Americans at Risk Approximately 49% of adults have at least one ...

23

Propiedades mecánicas de laminados estructurales con madera de encino  

Microsoft Academic Search

Oakwood (Quercus sp) is a very important forest resource in México, but its use is very reduced. In order to provide options to increase the utilization of oakwood, this paper presents the procedures of fabrication of nine oakwood glue laminated beams, which were tested in bending and the mechanical properties obtained are presented. Two species were collected and sawn to

V. Rubén; Ordóñez Candelaria; Arturo Quiroz Soto; Reyna Paula; Zarate Morales

1998-01-01

24

Fuente de Energa Polisacridos de almacenamiento Polisacridos estructurales  

E-print Network

;#12;Determinantes sanguíneos #12;Carbohidratos: Un sistema de codificación de alta densidad estereoquímica Los sistema de codificación de alta densidad estereoquímica #12;¡Combinatoria crece exponencialmente con Carbohidratos: Un sistema de codificación de alta densidad estereoquímica #12;8 El Código Azucarado Lectinas

Mejía-Monasterio, Carlos

25

Factor Lines  

NSDL National Science Digital Library

This flash applet provides students with an activity to become more familiar with factors and multiples. The challenge is to arrange the four number cards (1, 2, 3 and 21) on a square of the grid to make as many different diagonal, vertical or horizontal lines as possible. The number card can be placed on a square of the grid if the square is the same number, a multiple of that number and or a factor of that number. Users have the ability to change the difficulty level. The Teachers' Notes page offers rationale, suggestions for implementation, key discussion questions, ideas for extension and support.

26

Bayes Factors  

Microsoft Academic Search

In a 1935 paper and in his book Theory of Probability, Jeffreys developed a methodology for quantifying the evidence in favor of a scientific theory. The centerpiece was a number, now called the Bayes factor, which is the posterior odds of the null hypothesis when the prior probability on the null is one-half. Although there has been much discussion of

Robert E. Kass; Adrian E. Raftery

1995-01-01

27

Hyperpolarizing factors.  

PubMed

There is now overwhelming evidence for factors, other than nitric oxide (NO), that mediate endothelium-dependent vasodilation by hyperpolarizing the underlying smooth muscle via activation of Ca2+-activated K+ channels. Although the identity of endothelium-derived hyperpolarizing factor (EDHF) remains to be established, cytochrome P450 (CYP)-dependent metabolites of arachidonic acid (AA), namely, the epoxides, fulfill several of the criteria required for consideration as putative mediators of endothelium-dependent hyperpolarization. They are produced by the endothelium, released in response to vasoactive hormones, and elicit vasorelaxation via stimulation of Ca2+-activated K+ channels. Our studies in the rat indicate that, of the epoxides, 5,6-epoxyeicosatrienoic acid (5,6-EET) is the most likely mediator of NO-independent, but CYP-dependent coronary vasodilation in response to bradykinin. Studies in the rat kidney, however, support the existence of additional EDHFs as acetylcholine also exhibits NO-independent vasodilation that is unaffected by CYP inhibitors in concentrations that attenuate responses to bradykinin. In some blood vessels, NO may tonically suppress the expression of CYP-dependent EDHF. In the event of impaired NO synthesis, therefore, a CYP-dependent vasodilator mechanism may serve as a backup to a primary NO-dependent mechanism, although they may act in concert. In other vessels, particularly microvessels, an EDHF may constitute the major vasodilator mechanism for hormones and other physiological stimuli. EDHFs appear to be important regulators of vascular tone; alterations in this system can be demonstrated in hypertension and diabetes, conditions associated with altered endothelium-dependent vasodilator responsiveness. PMID:9464448

Quilley, J; Fulton, D; McGiff, J C

1997-11-15

28

Estudios Sociales Para ninos de cinco anos.  

ERIC Educational Resources Information Center

Suggests that kindergarten teachers should once a week bring to class a news photograph which they can discuss with the children. Such an exercise can be used to create among the children a wider awareness of the world and to counter their tendency to focus exclusively on the self. (Author/RH)

Van Camp, Sara S.

1982-01-01

29

Power Factor Compensation (PFC) Power Factor Compensation  

E-print Network

Power Factor Compensation (PFC) Power Factor Compensation The power factor (PF) is defined as the ratio between the active power and the apparent power of a system. If the current and voltage are periodic with period , and [ ), then the active power is defined by ( ) ( ) (their inner product

Knobloch,Jürgen

30

Learning with matrix factorizations  

E-print Network

Matrices that can be factored into a product of two simpler matrices can serve as a useful and often natural model in the analysis of tabulated or high-dimensional data. Models based on matrix factorization (Factor Analysis, ...

Srebro, Nathan, 1974-

2004-01-01

31

Risk Factors and Prevention  

MedlinePLUS

... Resources Risk Factors & Prevention Back to Patient Resources Risk Factors & Prevention Even people who look healthy and ... Blood Pressure , high cholesterol, diabetes, and thyroid disease. Risk Factors For Arrhythmias and Heart Disease The following ...

32

Risk Factors for Scleroderma  

MedlinePLUS

... You are here: Home For Patients Risk Factors Risk Factors for Scleroderma The cause of scleroderma is ... what biological factors contribute to scleroderma pathogenesis. Genetic Risk Scleroderma does not tend to run in families ...

33

Feature Tracking Factorization  

E-print Network

Feature Tracking KLT Tracker Enhancements to KLT Experimental Results Factorization Tomasi-Kanade Experimental Results Factorization Tomasi-Kanade Algorithm Experimental Results Conclusions References Outline Factorization Tomasi-Kanade Algorithm Experimental Results 4 Conclusions 5 References #12;Feature Tracking

North Carolina at Chapel Hill, University of

34

Exponential family factors for Bayesian factor analysis.  

PubMed

Expressing data as linear functions of a small number of unknown variables is a useful approach employed by several classical data analysis methods, e.g., factor analysis, principal component analysis, or latent semantic indexing. These models represent the data using the product of two factors. In practice, one important concern is how to link the learned factors to relevant quantities in the context of the application. To this end, various specialized forms of the factors have been proposed to improve interpretability. Toward developing a unified view and clarifying the statistical significance of the specialized factors, we propose a Bayesian model family. We employ exponential family distributions to specify various types of factors, which provide a unified probabilistic formulation. A Gibbs sampling procedure is constructed as a general computation routine. We verify the model by experiments, in which the proposed model is shown to be effective in both emulating existing models and motivating new model designs for particular problem settings. PMID:24808477

Li, Jun; Tao, Dacheng

2013-06-01

35

La logística como factor de competitividad de las Pymes en las Américas  

Microsoft Academic Search

En América Latina y el Caribe, a pesar de las mejoras experimentadas a nivel logístico en los últimos años, persisten algunos problemas estructurales que suponen un freno a las exportaciones de las empresas de la región, afectando de manera particular a las pymes. En este documento se hace hincapié en cuáles son los principales desafíos que se deben afrontar en

Carlos Kirby; Nicolau Brosa

2011-01-01

36

Positive tensor factorization  

Microsoft Academic Search

A novel fixed point algorithm for positive ten- sor factorization (PTF) is introduced. The update rules efficiently minimize the reconstruction error of a positive tensor over positive factors. Tensors of arbitrary order can be factorized, which extends earlier results in the lit- erature. Experiments show that the factors of PTF are easier to interpret than those produced by methods based

Max Welling; Markus Weber

2001-01-01

37

Constructivism, Factoring, and Beliefs.  

ERIC Educational Resources Information Center

Discusses errors made by remedial intermediate algebra students in factoring polynomials in light of student definitions of factoring. Found certain beliefs about factoring to logically imply many of the errors made. Suggests that belief-based teaching can be successful in teaching factoring. (16 references) (Author/MKR)

Rauff, James V.

1994-01-01

38

Important Water Quality Factors  

NSDL National Science Digital Library

This site provides basic information about factors commonly analyzed in water quality studies of drinking water, waste water and natural water. The factors are listed alphabetically with descriptions and explanations about what the results of measurements mean in environmental terms.

39

Power Factor Improvement  

E-print Network

of the equipment, and will be shown at the conference. Typical billing methods involving power factors are described. Then, the alternative methods of improving power factor are discussed with advantages and disadvantages of each. Here, the advantages...

Viljoen, T. A.

1979-01-01

40

Factoring Polynomials and Fibonacci.  

ERIC Educational Resources Information Center

Discusses the factoring of polynomials and Fibonacci numbers, offering several challenges teachers can give students. For example, they can give students a polynomial containing large numbers and challenge them to factor it. (JN)

Schwartzman, Steven

1986-01-01

41

Antihemophilic Factor (Human)  

MedlinePLUS

Your doctor has ordered antihemophilic factor (human), an antihemophilic factor, to help your blood to clot. The drug will be either injected directly into your vein or added to an intravenous fluid ...

42

Factors, Arrays and Commutativity  

NSDL National Science Digital Library

Students look at different arrangements of desks, discuss the number of factor pairs and relate this to the commutative property of multiplication. They learn why they must try factors up to the square root of a number.

WNET

2008-08-22

43

Chromium wash & leach factors  

SciTech Connect

This report estimates chromium wash and leach factors using a waste type modeling approach. The model produces reasonable chromium wash-leach factor predictions that can be used in the Hanford Tank Waste Operations Simulator model.

LAMBERT, S.L.; MEACHAM, J.E.

2003-04-24

44

Multilevel Mixture Factor Models  

ERIC Educational Resources Information Center

Factor analysis is a statistical method for describing the associations among sets of observed variables in terms of a small number of underlying continuous latent variables. Various authors have proposed multilevel extensions of the factor model for the analysis of data sets with a hierarchical structure. These Multilevel Factor Models (MFMs)…

Varriale, Roberta; Vermunt, Jeroen K.

2012-01-01

45

Factor X deficiency  

Microsoft Academic Search

Factor X is one of the vitamin K-dependent serine proteases. It plays a crucial role in the coagulation cascade, as the first enzyme in the common pathway of thrombus formation. The gene for factor X maps to the long arm of chromosome 13, approximately 2.8 kb downstream of the factor VII gene. The gene consists of eight exons, each of

James Uprichard; David J. Perry

2002-01-01

46

Bayesian Exploratory Factor Analysis.  

PubMed

This paper develops and applies a Bayesian approach to Exploratory Factor Analysis that improves on ad hoc classical approaches. Our framework relies on dedicated factor models and simultaneously determines the number of factors, the allocation of each measurement to a unique factor, and the corresponding factor loadings. Classical identification criteria are applied and integrated into our Bayesian procedure to generate models that are stable and clearly interpretable. A Monte Carlo study confirms the validity of the approach. The method is used to produce interpretable low dimensional aggregates from a high dimensional set of psychological measurements. PMID:25431517

Conti, Gabriella; Frühwirth-Schnatter, Sylvia; Heckman, James J; Piatek, Rémi

2014-11-01

47

ANÁLISIS, DISEÑO DE ELEMENTOS ESTRUCTURALES UTILIZANDO HORMIGÓN DE ALTO DESEMPEÑO (HAD) Y COMPARACIÓN CON ELEMENTOS ESTRUCTURALES DISEÑADOS CON HORMIGONES CONVENCIONALES PARA SOPORTAR LAS MISMAS CONDICIONES DE CARGA  

Microsoft Academic Search

The objective of this topic is to apply the acquired knowledge, to realize the analysis, design of structural elements using High Performance Concrete (HPC) and to compare them with structural elements designed with Conventional Concretes to support the same conditions of load. The High Performance Concrete (HPC) is an innovative material, that promises important applications in the industry of special

Cecilia I. Velasco Ochoa; Carlos F. Peña Ochoa; Mario D. Cantos Salazar

48

Meson electromagnetic form factors  

E-print Network

The electromagnetic structure of the pseudoscalar meson nonet is completely described by the sophisticated Unitary&Analytic model, respecting all known theoretical properties of the corresponding form factors.

Stanislav Dubnicka; Anna Z. Dubnickova

2012-10-23

49

Radiation view factor program  

NASA Technical Reports Server (NTRS)

Computer program, RAVFAC, calculates diffuse radiation view factors, using contour integrals. Technique is combined with finite difference /double summation/ technique to compose total program package.

Lovin, J. K.; Lubkowitz, A. W.

1971-01-01

50

SOCIOLOGICAL METHODS & RESEARCHRaftery / BAYES FACTORS Bayes Factors and BIC  

E-print Network

SOCIOLOGICAL METHODS & RESEARCHRaftery / BAYES FACTORS Bayes Factors and BIC Comment on "A Critique for Bayes factors. I thank Weakliem for bringingthissubtlebutimportanttopictotheattentionofsociologists. In 1986, I proposed replacing P values by Bayes factors as the basis for hypothesis testing and model

Raftery, Adrian

51

Exogenous Factors and Psoriasis  

Microsoft Academic Search

Psoriasis is a chronic relapsing disease characterized by variable clinical features. Several factors may exacerbate its manifestations, or even trigger the disease, such as traumatic injury to the skin, physical and psychological stress, cold weather, excessive alcohol intake, and drugs such as lithium and beta-blockers. We describe the most common features of psoriasis and the exogenous factors that may induce,

E. Dika; H. I. Maibach

2004-01-01

52

Vitiligo – Exogenous Factors  

Microsoft Academic Search

Vitiligo is an acquired depigmentary disorder of the skin that results from the selective destruction of melanocytes. The etiology of vitiligo is poorly understood. There appears to be a genetic predisposition, but additional factors are probably involved. The purpose of this article is to outline the factors that might play a role in the development of vitiligo. These include trauma

Hagit Matz; Ethel Tur

2004-01-01

53

Exposure Factors Program  

EPA Science Inventory

The development of the latest version of the Exposure Factors Handbook (EFH): 2011 Edition (EPA/600/R-09/052F) has maintained the need for a more comprehensive program that addresses issues related to exposure factors. Since the first version of the EFH was r...

54

Perturbative QCD factorization of ?????  

NASA Astrophysics Data System (ADS)

In this paper, we firstly verify that the factorization hypothesis is valid for the exclusive process ????? at the next-to-leading order (NLO) with the collinear factorization approach, and then extend this proof to the case of the kT factorization approach. We particularly show that at the NLO level, the soft divergences in the full quark level calculation could be canceled completely as for the ????? process where only the pseudoscalar ? meson is involved, and the remaining collinear divergences can be absorbed into the NLO hadron wave functions. The full amplitudes can be factorized as the convolution of the NLO wave functions and the infrared-finite hard kernels with these factorization approaches. We also write out the NLO meson distribution amplitudes in the form of nonlocal matrix elements.

Cheng, Shan; Xiao, Zhen-Jun

2014-10-01

55

Factors augmenting allergic reactions.  

PubMed

Elicitors of anaphylactic reactions are any sources of protein with allergenic capacity. However, not all allergic reactions end up in the most severe form of anaphylaxis. Augmenting factors may explain why certain conditions lead to anaphylaxis. Augmenting factors may exhibit three effects: lowering the threshold, increasing the severity, and reversing acquired clinical tolerance. Common augmenting factors are physical exercise, menstruation, NSAIDs, alcohol, body temperature, acute infections, and antacids. Therapeutic options may address causative, preventive, pragmatic, or symptomatic considerations: avoid the eliciting food, take an antihistamine before any situation with a possible risk of augmentation, separate food and sport (at least for 2 h), and carry an adrenaline autoinjector at all times. Individual patterns include summation effects and specific patterns. In conclusion, in the case of a suggestive history but a negative oral challenge, one should consider the possible involvement of augmenting factors; after anaphylactic reactions, always ask for possible augmentation and other risk factors during the recent past; if augmentation is suspected, oral food challenges should be performed in combination with augmenting factors; and in the future, standardized challenge protocols including augmenting factors should be established. PMID:25306896

Niggemann, B; Beyer, K

2014-12-01

56

Environmental Factors in Autism  

PubMed Central

Autism is a neurodevelopmental disorders characterized by impairments in communication and social behavior, and by repetitive behaviors. Although genetic factors might be largely responsible for the occurrence of autism they cannot fully account for all cases and it is likely that in addition to a certain combination of autism-related genes, specific environmental factors might act as risk factors triggering the development of autism. Thus, the role of environmental factors in autism is an important area of research and recent data will be discussed in this review. Interestingly, the results show that many environmental risk factors are interrelated and their identification and comparison might unveil a common scheme of alterations on a contextual as well as molecular level. For example, both, disruption in the immune system and in zinc homeostasis may affect synaptic transmission in autism. Thus, here, a model is proposed that interconnects the most important and scientifically recognized environmental factors. Moreover, similarities in how these risk factors impact synapse function are discussed and a possible influence on an already well described genetic pathway leading to the development of autism via zinc homeostasis is proposed. PMID:23346059

Grabrucker, Andreas M.

2013-01-01

57

Beware the impact factor  

NASA Astrophysics Data System (ADS)

The journal impact factor is a good predictor of the quality of journals as measured by citations to primary research articles. It is, however, a poor indicator of citations to specific papers or of the future performance of individual researchers.

2013-02-01

58

Factorization breaking in diffraction  

NASA Astrophysics Data System (ADS)

The measurements of diffractive dijet and open charm electron-proton cross-sections in deep-inelastic scattering (DIS) and photoproduction at HERA are discussed with an emphasis on possible quantum chromodynamics (QCD) factorization breaking.

Valkárová, Alice

2015-02-01

59

Automated Factor Slice Sampling.  

PubMed

Markov chain Monte Carlo (MCMC) algorithms offer a very general approach for sampling from arbitrary distributions. However, designing and tuning MCMC algorithms for each new distribution, can be challenging and time consuming. It is particularly difficult to create an efficient sampler when there is strong dependence among the variables in a multivariate distribution. We describe a two-pronged approach for constructing efficient, automated MCMC algorithms: (1) we propose the "factor slice sampler", a generalization of the univariate slice sampler where we treat the selection of a coordinate basis (factors) as an additional tuning parameter, and (2) we develop an approach for automatically selecting tuning parameters in order to construct an efficient factor slice sampler. In addition to automating the factor slice sampler, our tuning approach also applies to the standard univariate slice samplers. We demonstrate the efficiency and general applicability of our automated MCMC algorithm with a number of illustrative examples. PMID:24955002

Tibbits, Matthew M; Groendyke, Chris; Haran, Murali; Liechty, John C

2014-01-01

60

Israelachvili Packing factor  

NSDL National Science Digital Library

Israelachvili Packing factor. The geometry of associated structures depends upon "packing" properties of the molecule: the optimal area of the head group, a0, volume of the chain, V, and the critical length of the tether, lc.

Iacovella, Christopher R.

2006-08-02

61

Automated Factor Slice Sampling  

PubMed Central

Markov chain Monte Carlo (MCMC) algorithms offer a very general approach for sampling from arbitrary distributions. However, designing and tuning MCMC algorithms for each new distribution, can be challenging and time consuming. It is particularly difficult to create an efficient sampler when there is strong dependence among the variables in a multivariate distribution. We describe a two-pronged approach for constructing efficient, automated MCMC algorithms: (1) we propose the “factor slice sampler”, a generalization of the univariate slice sampler where we treat the selection of a coordinate basis (factors) as an additional tuning parameter, and (2) we develop an approach for automatically selecting tuning parameters in order to construct an efficient factor slice sampler. In addition to automating the factor slice sampler, our tuning approach also applies to the standard univariate slice samplers. We demonstrate the efficiency and general applicability of our automated MCMC algorithm with a number of illustrative examples. PMID:24955002

Tibbits, Matthew M.; Groendyke, Chris; Haran, Murali; Liechty, John C.

2013-01-01

62

New microbial growth factor.  

PubMed Central

A screening procedure was used to isolate from soil a Penicillium sp., two bacterial isolates, and a Streptomyces sp. that produced a new microbial growth factor. This factor was an absolute growth requirement for three soil bacteria. The Penicillium sp. and one of the bacteria requiring the factor, an Arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. It did not seem to be related to the siderochromes. It was not present in soil extract, rumen fluid, or any other medium component tested. It appears to be a glycoprotein of high molecular weight, and it has high specific activity. When added to the diets for a meadow vole mammalian test system, it caused an increased consumption of diet without a concurrent increase in rate of weight gain. PMID:327929

Bok, S H; Casida, L E

1977-01-01

63

Angiogenic Factors and Preeclampsia  

PubMed Central

Summary Preeclampsia, a hypertensive disorder peculiar to pregnancy, is a systemic syndrome that appears to originate in the placenta and is characterized by widespread maternal endothelial dysfunction. Until recently, the molecular pathogenesis of phenotypic preeclampsia was largely unknown, but recent observations support the hypothesis that altered expression of placental anti-angiogenic factors are responsible for the clinical manifestation of the disease. Soluble Flt1 and soluble endoglin, secreted by the placenta, are increased in the maternal circulation weeks before the onset of preeclampsia. These anti-angiogenic factors produce systemic endothelial dysfunction, resulting in hypertension, proteinuria, and the other systemic manifestations of preeclampsia. The molecular basis for placental dysregulation of these pathogenic factors remains unknown, and as of 2010 the role of angiogenic proteins in early placental vascular development was starting to be explored. The data linking angiogenic factors to preeclampsia have exciting clinical implications, and likely will transform the detection and treatment of preeclampsia. PMID:21266263

Maynard, Sharon E.; Karumanchi, S. Ananth

2011-01-01

64

New microbial growth factor  

NASA Technical Reports Server (NTRS)

A screening procedure was used to isolate from soil a Penicillium sp., two bacterial isolates, and a Streptomyces sp. that produced a previously unknown microbial growth factor. This factor was an absolute growth requirement for three soil bacteria. The Penicillium sp. and one of the bacteria requiring the factor, an Arthrobacter sp., were selected for more extensive study concerning the production and characteristics of the growth factor. It did not seem to be related to the siderochromes. It was not present in soil extract, rumen fluid, or any other medium component tested. It appears to be a glycoprotein of high molecular weight and has high specific activity. When added to the diets for a meadow-vole mammalian test system, it caused an increased consumption of diet without a concurrent increase in rate of weight gain.

Bok, S. H.; Casida, L. E., Jr.

1977-01-01

65

Coagulation Factors Test  

MedlinePLUS

... online through http://www.ohsu.edu . Elstrom, R. (2001 October 21, Updated). Bleeding disorders. MEDLINEplus Health Information, ... gov/medlineplus/ency/article/001304.htm . Elstrom, R. (2001 November 10, Updated). Factor XII assay. MEDLINEplus Health ...

66

Aerospace Human Factors  

NASA Technical Reports Server (NTRS)

The following contains the final report on the activities related to the Cooperative Agreement between the human factors research group at NASA Ames Research Center and the Psychology Department at San Jose State University. The participating NASA Ames division has been, as the organization has changed, the Aerospace Human Factors Research Division (ASHFRD and Code FL), the Flight Management and Human Factors Research Division (Code AF), and the Human Factors Research and Technology Division (Code IH). The inclusive dates for the report are November 1, 1984 to January 31, 1999. Throughout the years, approximately 170 persons worked on the cooperative agreements in one capacity or another. The Cooperative Agreement provided for research personnel to collaborate with senior scientists in ongoing NASA ARC research. Finally, many post-MA/MS and post-doctoral personnel contributed to the projects. It is worth noting that 10 former cooperative agreement personnel were hired into civil service positions directly from the agreements.

Jordan, Kevin

1999-01-01

67

Myeloid growth factors.  

PubMed

Febrile neutropenia, a common side effect of myelosuppressive chemotherapy in patients with cancer, can result in prolonged hospitalization and broad-spectrum antibiotic use, often prompting treatment delays or dose reductions of drug regimens. Prophylactic use of myeloid growth factors (mainly the colony-stimulating factors filgrastim and pegfilgrastim) in patients of heightened risk can reduce the severity and duration of febrile neutropenia. The NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) for Myeloid Growth Factors provide recommendations on the use of these agents mainly in the oncology setting based on clinical evidence and expert consensus. This version includes revisions surrounding the issue of timing of pegfilgrastim administration. It also includes new sections on tbo-filgrastim, a recently approved agent that is biologically similar to filgrastim, and the role of myeloid growth factors in the hematopoietic cell transplant setting. PMID:24142827

Crawford, Jeffrey; Armitage, James; Balducci, Lodovico; Becker, Pamela Sue; Blayney, Douglas W; Cataland, Spero R; Heaney, Mark L; Hudock, Susan; Kloth, Dwight D; Kuter, David J; Lyman, Gary H; McMahon, Brandon; Rugo, Hope S; Saad, Ayman A; Schwartzberg, Lee S; Shayani, Sepideh; Steensma, David P; Talbott, Mahsa; Vadhan-Raj, Saroj; Westervelt, Peter; Westmoreland, Michael; Dwyer, Mary; Ho, Maria

2013-10-01

68

Factor X deficiency  

MedlinePLUS

... a vein (intravenously). Knowing that you have a bleeding disorder helps the doctor can take extra care if ... the condition is mild or you get treatment. Inherited factor X deficiency is a life-long condition. ...

69

Limiting Factors in Ecosystems  

NSDL National Science Digital Library

This unit, designed to span two class periods, helps students understand that physical factors, particularly temperature and precipitation, limit the growth of plant ecosystems. The activity begins with a discussion in which students develop their own ideas about the role of temperature, precipitation, and environment on plant growth. They will then examine X-Y graphs of vegetation growth, temperature, and precipitation versus month for four diverse ecosystems to determine which climatic factor is limiting growth. A worksheet and scoring rubric are provided.

70

NECROSIS FACTOR AND TUMOR  

E-print Network

Activated monocytes produce a variety of cytokines that are involved in inflammation, such as IL-1, TNF, chemotactic factors, transforming growth factor R, platelet-derived growth factor, and IFN-a and-Q (1). Chemotactic factors released at foci of injury or bacterial invasion are thought to mediate directed migration of leukocytes into inflammatory sites. Since the leukocyte composition of the inflammatory infiltrate depends on the temporal stage of the lesion (2) and the nature of the stimulus (3), it follows that some chemoattractants should be specific for a given type of leukocyte. We recently showed that LPS-stimulated monocytes produce a chemotactic factor that attracts neutrophils, but not monocytes (4). We purified this factor to homogeneity and described the N1-12-terminal sequence of the first 42 amino acids (5). We now report molecular cloning and sequencing ofthe full-length cDNA for this monocyte-derived neutrophil chemotactic factor (MDNCF) ' and the deduced amino acid sequence of the entire molecule. Specific cDNA probes also enabled us to test the capacity of a number of cytokines to induce MDNCF mRNA expression in human PBMC. The stimulation of MDNCF mRNA expression by IL-1 and TNF suggests that the local pro-inflammatory action of these cytokines may be mediated by induction of chemotactic factor secretion. Materials and Methods cDNA Cloning ofMDNCF and Nucleotide Sequence. Normal human PBMC were first fractionated by Ficoll-Hypaque and plastic adherent cells (> 90 % nonspecific esterase-positive monocytes), were cultured in RPMI-1640 medium supplemented with 1 % FCS and 10 ug/ml

71

FGF growth factor analogs  

DOEpatents

The present invention provides a fibroblast growth factor heparin-binding analog of the formula: ##STR00001## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, X, Y and Z are as defined, pharmaceutical compositions, coating compositions and medical devices including the fibroblast growth factor heparin-binding analog of the foregoing formula, and methods and uses thereof.

Zamora, Paul O. (Gaithersburg, MD); Pena, Louis A. (Poquott, NY); Lin, Xinhua (Plainview, NY); Takahashi, Kazuyuki (Germantown, MD)

2012-07-24

72

Electromagetic proton form factors  

E-print Network

The electromagnetic form factors are crucial to our understanding of the proton internal structure, and thus provide a strong constraint of the distributions of the charge and magnetization current within the proton. We adopted the quark-parton model for calculating and understanding the charge structure of the proton interms of the electromagnetic form factors. A remarkable agreement with the available experimental evidence is found.

M Y Hussein

2006-10-31

73

Phase unwrapping by factorization  

Microsoft Academic Search

An algorithm for the numerical factorization of very high degree but well-conditioned polynomials is developed. This is used to factor the z-transform of finite-length signals, and the zeros are used to calculate the unwrapped phase. The method has been tested on signals up to 512 points in length. A complete Fortran 77 program is given for the case of a

KENNETH STEIGLITZ; BRADLEY DICKINSON

1982-01-01

74

Factors affecting neonatal jaundice  

Microsoft Academic Search

Plasma bilirubin was estimated on 690 term infants on about the 6th day of life. Perinatal factors were recorded and the results analysed. Hyperbilirubinaemia was defined as a level greater than 205 micromol\\/1 (12 mg\\/100 ml) and this was present in 20% of cases. Three factors--epidural analgesia, breast feeding, and poor weight recovery--showed highly significant associations with jaundice. The relative

B Wood; P Culley; C Roginski; J Powell; J Waterhouse

1979-01-01

75

Interest rates factor model  

NASA Astrophysics Data System (ADS)

Interdependence of the interest rates of the US, the UK, and Japan is analyzed in this work by means of spectral analysis and network methods. A predominant effective factor in the interest rate market is which country floats a bond issue, and a minor effective factor is time to maturity of bonds. Power-law cross-correlation among different countries is analyzed by the detrended cross-correlation analysis method. Long-range cross-correlation is found between the first factors of interest rate, while there is no cross-correlation between some of the second factors. The tail dependency is indicated by tail indices from Archimedean copulas, including an empirical copula. In contrast to other pairs, the US-UK first factor pair has tail dependencies in both the upper-tail and lower-tail. Dynamic properties of interest rate are modeled by a stochastic volatility model. The properties of mean reverting and volatility clustering are observed and reflected in this model. The proposed simulation method combines the dependence structures and the factor dynamics model; it simultaneously describes the interest rates of different countries.

Lee, Sangwook; Kim, Min Jae; Kim, Soo Yong

2011-07-01

76

Factor Loading Estimation Error and Stability Using Exploratory Factor Analysis  

ERIC Educational Resources Information Center

Exploratory factor analysis (EFA) is commonly employed to evaluate the factor structure of measures with dichotomously scored items. Generally, only the estimated factor loadings are provided with no reference to significance tests, confidence intervals, and/or estimated factor loading standard errors. This simulation study assessed factor loading…

Sass, Daniel A.

2010-01-01

77

Factor Analysis and Counseling Research  

ERIC Educational Resources Information Center

Topics discussed include factor analysis versus cluster analysis, analysis of Q correlation matrices, ipsativity and factor analysis, and tests for the significance of a correlation matrix prior to application of factor analytic techniques. Techniques for factor extraction discussed include principal components, canonical factor analysis, alpha…

Weiss, David J.

1970-01-01

78

Multi-factor authentication  

DOEpatents

Detection and deterrence of spoofing of user authentication may be achieved by including a cryptographic fingerprint unit within a hardware device for authenticating a user of the hardware device. The cryptographic fingerprint unit includes an internal physically unclonable function ("PUF") circuit disposed in or on the hardware device, which generates a PUF value. Combining logic is coupled to receive the PUF value, combines the PUF value with one or more other authentication factors to generate a multi-factor authentication value. A key generator is coupled to generate a private key and a public key based on the multi-factor authentication value while a decryptor is coupled to receive an authentication challenge posed to the hardware device and encrypted with the public key and coupled to output a response to the authentication challenge decrypted with the private key.

Hamlet, Jason R; Pierson, Lyndon G

2014-10-21

79

Optimizing Power Factor Correction  

E-print Network

the capacity or demand charge and the energy charge. Increases of the annual electric cost as the power factor decreases are shown in Table I under the assumptions that each month of the year is identical, the metered KW demand is 1,000 kW... .. 300,000 kWh/mo Meter Demand = 1,000 kW Yearly Yearly Yearly Penalty for Billing Capacity Energy Total Low Power Power Capacity Charge Charge Cost Factor Factor kVA $/yr ---- ~~ -1!.E 1.00 1,000 46,920 94,800 186,868 0.96 1,042 48,795 95...

Phillips, R. K.; Burmeister, L. C.

80

DSN human factors project  

NASA Technical Reports Server (NTRS)

The project plan was to hold focus groups to identify the factors influencing the ease of use characteristics of software and to bond the problem. A questionnaire survey was conducted to evaluate those factors which were more appropriately measured with that method. The performance oriented factors were analyzed and relationships hypothesized. The hypotheses were put to test in the experimental phase of the project. In summary, the initial analysis indicates that there is an initial performance effect favoring computer controlled dialogue but the advantage fades fast as operators become experienced. The user documentation style is seen to have a significant effect on performance. The menu and prompt command formats are preferred by inexperienced operators. The short form mnemonic is least favored. There is no clear best command format but the short form mnemonic is clearly the worst.

Chafin, R. L.; Martin, T. H.

1980-01-01

81

Psychological Factors in Asthma  

PubMed Central

Asthma has long been considered a condition in which psychological factors have a role. As in many illnesses, psychological variables may affect outcome in asthma via their effects on treatment adherence and symptom reporting. Emerging evidence suggests that the relation between asthma and psychological factors may be more complex than that, however. Central cognitive processes may influence not only the interpretation of asthma symptoms but also the manifestation of measurable changes in immune and physiologic markers of asthma. Furthermore, asthma and major depressive disorder share several risk factors and have similar patterns of dysregulation in key biologic systems, including the neuroendocrine stress response, cytokines, and neuropeptides. Despite the evidence that depression is common in people with asthma and exerts a negative impact on outcome, few treatment studies have examined whether improving symptoms of depression do, in fact, result in better control of asthma symptoms or improved quality of life in patients with asthma. PMID:20525122

2008-01-01

82

The Transcription Factor Encyclopedia  

PubMed Central

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe. PMID:22458515

2012-01-01

83

[Beam quality conversion factor].  

PubMed

This report describes the update of the beam quality conversion factor k(Q,Q0) of the standard dosimetry protocol in Japan. The k(Q,Q0) corrects for the difference between the response of an ionization chamber in the reference beam quality Q0 used for calibrating the chamber and in the actual user beam quality Q. All changes of k(Q,Q0) were caused by the perturbation correction factors which were recalculated by Monte Carlo simulation. With a calculation process, unsolved problems in this update are also discussed here. PMID:24893494

Kawachi, Toru; Katayose, Tetsurou

2013-01-01

84

Factor D Enzyme  

NASA Technical Reports Server (NTRS)

The trauma caused by the open heart surgery often triggers massive inflammation because the immune system overreacts. Factor D, the protein which plays a key role in the biological steps that activate this immune response prevents the imune system from inappropriately rurning out of control, allowing the patient to recover more rapidly. Factor D blockers, with their great potential to alleviate the complication of inflammation associated with heart surgery, are now being developed for clinical trials. These new drugs, developed from space research, should be commercially available as soon as year 2001.

2004-01-01

85

WRKY transcription factors  

PubMed Central

WRKY transcription factors are one of the largest families of transcriptional regulators found exclusively in plants. They have diverse biological functions in plant disease resistance, abiotic stress responses, nutrient deprivation, senescence, seed and trichome development, embryogenesis, as well as additional developmental and hormone-controlled processes. WRKYs can act as transcriptional activators or repressors, in various homo- and heterodimer combinations. Here we review recent progress on the function of WRKY transcription factors in Arabidopsis and other plant species such as rice, potato, and parsley, with a special focus on abiotic, developmental, and hormone-regulated processes. PMID:24492469

Bakshi, Madhunita; Oelmüller, Ralf

2014-01-01

86

Metric Conversion Factors  

NSDL National Science Digital Library

Brought to the Web by Washington State Department of Transportation, the Metric Conversion Factors site contains a wealth of helpful physical science and engineering information. As you might guess, all sorts of conversion factors are presented, such as for area, force, hard conversions for construction materials, length, mass, pavement, pipe, plate, power, pressure or stress, reinforcing steel, sheet metal, sieve, symbols, temperature, volume, and several others. Although it's not an online conversion calculator, all of the pages are set up for efficient printing so that students can have the information with them while doing homework.

87

The transcription factor encyclopedia.  

PubMed

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium of mini review articles on transcription factors (TFs) that is founded on the principles of open access and collaboration. Our consortium of over 100 researchers has collectively contributed over 130 mini review articles on pertinent human, mouse and rat TFs. Notable features of the TFe website include a high-quality PDF generator and web API for programmatic data retrieval. TFe aims to rapidly educate scientists about the TFs they encounter through the delivery of succinct summaries written and vetted by experts in the field. TFe is available at http://www.cisreg.ca/tfe. PMID:22458515

Yusuf, Dimas; Butland, Stefanie L; Swanson, Magdalena I; Bolotin, Eugene; Ticoll, Amy; Cheung, Warren A; Zhang, Xiao Yu Cindy; Dickman, Christopher T D; Fulton, Debra L; Lim, Jonathan S; Schnabl, Jake M; Ramos, Oscar H P; Vasseur-Cognet, Mireille; de Leeuw, Charles N; Simpson, Elizabeth M; Ryffel, Gerhart U; Lam, Eric W-F; Kist, Ralf; Wilson, Miranda S C; Marco-Ferreres, Raquel; Brosens, Jan J; Beccari, Leonardo L; Bovolenta, Paola; Benayoun, Bérénice A; Monteiro, Lara J; Schwenen, Helma D C; Grontved, Lars; Wederell, Elizabeth; Mandrup, Susanne; Veitia, Reiner A; Chakravarthy, Harini; Hoodless, Pamela A; Mancarelli, M Michela; Torbett, Bruce E; Banham, Alison H; Reddy, Sekhar P; Cullum, Rebecca L; Liedtke, Michaela; Tschan, Mario P; Vaz, Michelle; Rizzino, Angie; Zannini, Mariastella; Frietze, Seth; Farnham, Peggy J; Eijkelenboom, Astrid; Brown, Philip J; Laperrière, David; Leprince, Dominique; de Cristofaro, Tiziana; Prince, Kelly L; Putker, Marrit; del Peso, Luis; Camenisch, Gieri; Wenger, Roland H; Mikula, Michal; Rozendaal, Marieke; Mader, Sylvie; Ostrowski, Jerzy; Rhodes, Simon J; Van Rechem, Capucine; Boulay, Gaylor; Olechnowicz, Sam W Z; Breslin, Mary B; Lan, Michael S; Nanan, Kyster K; Wegner, Michael; Hou, Juan; Mullen, Rachel D; Colvin, Stephanie C; Noy, Peter John; Webb, Carol F; Witek, Matthew E; Ferrell, Scott; Daniel, Juliet M; Park, Jason; Waldman, Scott A; Peet, Daniel J; Taggart, Michael; Jayaraman, Padma-Sheela; Karrich, Julien J; Blom, Bianca; Vesuna, Farhad; O'Geen, Henriette; Sun, Yunfu; Gronostajski, Richard M; Woodcroft, Mark W; Hough, Margaret R; Chen, Edwin; Europe-Finner, G Nicholas; Karolczak-Bayatti, Magdalena; Bailey, Jarrod; Hankinson, Oliver; Raman, Venu; LeBrun, David P; Biswal, Shyam; Harvey, Christopher J; DeBruyne, Jason P; Hogenesch, John B; Hevner, Robert F; Héligon, Christophe; Luo, Xin M; Blank, Marissa Cathleen; Millen, Kathleen Joyce; Sharlin, David S; Forrest, Douglas; Dahlman-Wright, Karin; Zhao, Chunyan; Mishima, Yuriko; Sinha, Satrajit; Chakrabarti, Rumela; Portales-Casamar, Elodie; Sladek, Frances M; Bradley, Philip H; Wasserman, Wyeth W

2012-01-01

88

Role of human factor VIII in factor X activation.  

PubMed Central

The cofactor function of human Factor VIII in Factor X activation was investigated by an initial-rate assay of 3H-Factor X activation in the presence of human factor IXa, Ca2+, and either phospholipid or fresh washed human platelets. Purified Factor VIII that has not been activated by thrombin or Factor Xa supports Factor X activation after a lag of several minutes. A specific inhibitor of Factor Xa, which had no inhibitory activity against Factor IXa, markedly prolonged this lag, whereas specific thrombin inhibitors did not prolong the lag. These data support the conclusion that unactivated Factor VIII has no ability to support Factor X activation in a purified system until it is activated by Factor Xa feedback during the lag period. When Factor VIII was optimally preactivated by thrombin, the lag was completely abolished, regardless of the order of addition of the other reactants or the phospholipid source. These data indicate that there is no slow, time-dependent ordering of the reactants at the phospholipid or activated platelet surface if Factor VIII has been preactivated. Unactivated platelets did not support Factor X activation by Factors IXa and VIII. The effect of activated Factor VIII on the kinetics of bovine Factor X activation was primarily to increase the Vmax (54-fold), whereas with human Factor X, Factor VIII both increased the Vmax 56-fold and decreased the Km sixfold to 0.14 microM, similar to the plasma concentration of Factor X. Therefore, a change in the plasma factor X concentration would be expected to have a major effect on the rate of Factor X activation in vivo. PMID:6804496

Hultin, M B

1982-01-01

89

Integer factorization Daniel J. Bernstein  

E-print Network

Integer factorization Daniel J. Bernstein 2006.03.09 1 #12;Table of contents 1. Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 Finding small factors of one integer . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Finding small factors of many integers

Bernstein, Daniel

90

Factors Affecting Photosynthesis!  

E-print Network

Factors Affecting Photosynthesis! Temperature Eppley (1972) Light Sverdrup's Critical Depth-493, but the general concept is still valid! ! #12;PB opt & Temperature! #12;Photosynthesis & Temperature! Remember: in the laboratory, we can measure photosynthesis versus irradiance (PvsE) and calculate Ek, Pmax, and alpha

Kudela, Raphael M.

91

Factors Predicting Educational Productivity.  

ERIC Educational Resources Information Center

Since 1968 educational productivity studies at the University of Florida have been analyzing data from six States and one city. Linear regression was used to identify high and low productive units by measuring the relationship between statistically selected input factors and a measure of student achievement. Discriminant analysis was employed to…

Hanes, Carol E.; Jordan, K. Forbis

92

Causes and Risk Factors  

MedlinePLUS

... risk factor is repeated exposure to the chemical benzene, which damages the DNA of stem cells. Benzene is found in cigarette smoke, the most common known cause of exposure to this toxin. Benzene is also found in certain industrial settings. Strict ...

93

Factors Affecting Photosynthesis!  

E-print Network

4/21/13 1 Factors Affecting Photosynthesis! Temperature Eppley (1972) Light Sverdrup Michaelis-Menten versus PE curves! Photosynthesis and nutrient kinetics curves look similar because they are governed by the same process: Initial slope is dependent on amount of pigments (light) or cell

Kudela, Raphael M.

94

Rugby Fan Attraction Factors  

Microsoft Academic Search

Factors that influence sports fans' game attendance have been researched extensively in USA, Europe and Australia but rather less so in New Zealand. Fans provide the financial success for professional sports organisations, not only in terms of direct revenue from gate-takings, but also indirect revenue from sponsorship, television rights and merchandise. Influence upon rugby union fan attendance over four games

Ron Garland; Terry Macpherson; Kay Haughey

95

Introduction to human factors  

SciTech Connect

Some background is given on the field of human factors. The nature of problems with current human/computer interfaces is discussed, some costs are identified, ideal attributes of graceful system interfaces are outlined, and some reasons are indicated why it's not easy to fix the problems. (LEW)

Winters, J.M.

1988-03-01

96

Trends in Human Factors  

Microsoft Academic Search

An attempt is made to define the metamorphosis of the human factors area since World War II. While excellent work has been accomplished on problems relating to the detailed design of systems components, there is a significant lack of information relating to the gross problems of systems design. The need for research in this important area is emphasized.A plea is

Julien M. Christensen

1958-01-01

97

Yield Factors Lithography-  

E-print Network

Yield Factors Parametric Lithography- based Defect Density 0% 10% 20% 30% 40% 50% 60% 70% 80% 90% 100% 0.35 micron 0.25 micron 0.18 micron 0.13 micron 0.09 micron Process Technology NominalYields Defect Density Lithography-based Parametric Yield Yield-Aware Cache Architectures Serkan Ozdemir Debjit

Zhou, Hai

98

Scale Factor X  

NSDL National Science Digital Library

In this game, students navigate a maze to get to a math challenge. The three challenges are: move blue and green "fuel cells" around to match the ratios in the given containers; measure shapes to determine the scale factors needed to make them match the given templates; determine how to place bases on a map based on clues involving proportions.

2010-01-01

99

Factoring with the Turtle.  

ERIC Educational Resources Information Center

Provides Terrapin LOGO programs that use graphic manipulatives--squares, logs, and units--to form the area of a rectangle as a graphical representation for any trinomial of the form: Axx + Bx + C. An important component is the connection of the procedural skill of trinomial factoring to the visualization of the accompanying rectangular displays.…

Sirjani, Elizabeth A.

1991-01-01

100

A Formula for Factoring.  

ERIC Educational Resources Information Center

Suggests use of the quadratic formula to build understanding that connections between factors and solutions to equations work both ways. Making use of natural connections among concepts allows students to work more efficiently. Presents four sample problems showing the roots of equations. Messy quadratic equations with rational roots can be solved…

Roebuck, Kay I. Meeks

1997-01-01

101

Factor Trail Game  

NSDL National Science Digital Library

In this math game, learners identify the factors of a number to earn points. Although practicing a mundane skill, learners enjoy the work because of the game scenario. Built into this game is cooperative learning--learners check one another's work before points are awarded. This lesson guide includes questions for learners, assessment options, extensions, and reflection questions.

2008-01-01

102

Factor Analysis and AIC.  

ERIC Educational Resources Information Center

The Akaike Information Criterion (AIC) was introduced to extend the method of maximum likelihood to the multimodel situation. Use of the AIC in factor analysis is interesting when it is viewed as the choice of a Bayesian model; thus, wider applications of AIC are possible. (Author/GDC)

Akaike, Hirotugu

1987-01-01

103

Congenital factor XIII deficiency  

Microsoft Academic Search

Coagulation factor XIII (FXIII) has a major role in the final stage of blood coagulation, is im- portant for wound healing and maintaining preg- nancy. Severe congenital FXIII deficiency is a rare disorder with 1 patient in 1-3 million. Untreated, it causes bleeding events, with intracranial haem- orrhage being the major cause of death, impaired wound healing, and abortion. FXIII

Esther Meilic; Hans Peter

104

Alteraciones estructurales y ultraestructurales del encéfalo ocasionados por veneno de la serpiente mapanare (Bothrops colombiensis)  

Microsoft Academic Search

Structural and ultrastructural encephalic alter- ations caused by de poison of the snake mapanare (Bothrops colombiensis). The toxic and enzimatic activities of mapanare (Bothrops colombiensis) snake venom, whose activity affects nearly all of the mammal tissues have not been thoroughly stud- ied (structural or ultrastructurally) in the central nervous system (CNS). Adult C57\\/Bl mice were intravenously inoculated with venom concentrations

Rodríguez-Acosta A; Monterrey F; Céspedes G; Finol HJ

2003-01-01

105

FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES  

EPA Science Inventory

A series of modeling simulations were performed to develop an understanding of the underlying factors and principles involved in developing field sampling designs for measuring bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs. These simulations reveal...

106

FACTORS INFLUENCING THE DESIGN OF BIOACCUMULATION FACTOR AND BIOTA-SEDIMENT ACCUMULATION FACTOR FIELD STUDIES  

EPA Science Inventory

General guidance for designing field studies to measure bioaccumulation factors (BAFs) and biota-sediment accumulation factors (BSAFs) is not available. To develop such guidance, a series of modeling simulations were performed to evaluate the underlying factors and principles th...

107

Special factors and the combinatorics of suffix and factor automata  

Microsoft Academic Search

The suffix automaton (resp. factor automaton) of a finite word w is the minimal deterministic automaton recognizing the set of suffixes (resp. factors) of w. We study the relationships between the structure of the suffix and factor automata and classical combinatorial parameters related to the special factors of w. We derive formulae for the number of states of these automata. We also

Gabriele Fici

2011-01-01

108

Efficient factor GARCH models and factor-DCC models  

Microsoft Academic Search

We report that, in the estimation of univariate GARCH or multivariate generalized orthogonal GARCH (GO-GARCH) models, maximizing the likelihood is equivalent to making the standardized residuals as independent as possible. Based on this, we propose three factor GARCH models in the framework of GO-GARCH: independent-factor GARCH exploits factors that are statistically as independent as possible; factors in best-factor GARCH have

Kun Zhang; Laiwan Chan

2009-01-01

109

Factorized Diffusion Map Approximation.  

PubMed

Diffusion maps are among the most powerful Machine Learning tools to analyze and work with complex high-dimensional datasets. Unfortunately, the estimation of these maps from a finite sample is known to suffer from the curse of dimensionality. Motivated by other machine learning models for which the existence of structure in the underlying distribution of data can reduce the complexity of estimation, we study and show how the factorization of the underlying distribution into independent subspaces can help us to estimate diffusion maps more accurately. Building upon this result, we propose and develop an algorithm that can automatically factorize a high dimensional data space in order to minimize the error of estimation of its diffusion map, even in the case when the underlying distribution is not decomposable. Experiments on both the synthetic and real-world datasets demonstrate improved estimation performance of our method over the standard diffusion-map framework. PMID:25309676

Amizadeh, Saeed; Valizadegan, Hamed; Hauskrecht, Milos

2012-01-01

110

[Streptococcus pyogenes pathogenic factors].  

PubMed

The pathogenicity of ß-hemolytic group A streptococcus (GAS) is particularly diverse, ranging from mild infections, such as pharyngitis or impetigo, to potentially debilitating poststreptococcal diseases, and up to severe invasive infections such as necrotizing fasciitis or the dreaded streptococcal toxic shock syndrome. This variety of clinical expressions, often radically different in individuals infected with the same strain, results from a complex interaction between the bacterial virulence factors, the mode of infection and the immune system of the host. Advances in comparative genomics have led to a better understanding of how, following this confrontation, GAS adapts to the immune system's pressure, either peacefully by reducing the expression of certain virulence factors to achieve an asymptomatic carriage, or on the contrary, by overexpressing them disproportionately, resulting in the most severe forms of invasive infection. PMID:25456681

Bidet, Ph; Bonacorsi, S

2014-11-01

111

Atomic Scattering Factors  

NSDL National Science Digital Library

From the Lawrence Berkeley Laboratory's Center for X-Ray Optics, these "atomic scattering factors are based upon photoabsorption measurements of elements in their elemental state." These easy-to-use tables allow users to search out atomic scattering factor data by element and look up the x-ray properties of elements, the index of refraction for a compound material, the x-ray attenuation length of a solid, the x-ray transmission of a solid or a gas, and more. Most of the tables are accessed by way of an online query form with variables such as material, density, and photon energy range entered by the user. Most outputs come in plot form for quick viewing, or results may be retrieved as a text or postscript file for use with a personal plotting software.

112

Factors regulating microglia activation  

PubMed Central

Microglia are resident macrophages of the central nervous system (CNS) that display high functional similarities to other tissue macrophages. However, it is especially important to create and maintain an intact tissue homeostasis to support the neuronal cells, which are very sensitive even to minor changes in their environment. The transition from the “resting” but surveying microglial phenotype to an activated stage is tightly regulated by several intrinsic (e.g., Runx-1, Irf8, and Pu.1) and extrinsic factors (e.g., CD200, CX3CR1, and TREM2). Under physiological conditions, minor changes of those factors are sufficient to cause fatal dysregulation of microglial cell homeostasis and result in severe CNS pathologies. In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence. PMID:23630462

Kierdorf, Katrin; Prinz, Marco

2013-01-01

113

Growth factors for nanobacteria  

NASA Astrophysics Data System (ADS)

Nanobacteria are novel microorganisms recently isolated from fetal bovine serum and blood of cows and humans. These coccoid, gram negative bacteria in alpha-2 subgroup of Proteobacteria grow slowly under mammalian cell culture conditions but not in common media for microbes. Now we have found two different kinds of culture supplement preparations that improve their growth and make them culturable in the classical sense. These are supernatant fractions of conditioned media obtained from 1 - 3 months old nanobacteria cultures and from about a 2 weeks old Bacillus species culture. Both improved multiplication and particle yields and the latter increased their resistance to gentamicin. Nanobacteria cultured with any of the methods shared similar immunological property, structure and protein pattern. The growth supporting factors were heat-stabile and nondialyzable, and dialysis improved the growth promoting action. Nanobacteria formed stony colonies in a bacteriological medium supplemented with the growth factors. This is an implication that nanobacterial growth is influenced by pre-existing bacterial flora.

Ciftcioglu, Neva; Kajander, E. Olavi

1999-12-01

114

Human factors workplace considerations  

NASA Technical Reports Server (NTRS)

Computer workstations assume many different forms and play different functions today. In order for them to assume the effective interface role which they should play they must be properly designed to take into account the ubiguitous human factor. In addition, the entire workplace in which they are used should be properly configured so as to enhance the operational features of the individual workstation where possible. A number of general human factors workplace considerations are presented. This ongoing series of notes covers such topics as achieving comfort and good screen visibility, hardware issues (e.g., mouse maintenance), screen symbology features (e.g., labels, cursors, prompts), and various miscellaneous subjects. These notes are presented here in order to: (1) illustrate how one's workstation can be used to support telescience activities of many other people working within an organization, and (2) provide a single complete set of considerations for future reference.

Haines, Richard F.

1988-01-01

115

The Human Factor?  

Microsoft Academic Search

On March 27, 1977, an aircraft disaster occurred in Tenerife on the Canary Islands that sheds some light on the concept of\\u000a the human factor. The background to the accident was a terrorist attack on the airport in Las Palmas, which led to the redirection\\u000a of all air traffic to Tenerife including one Pan AM aircraft and one KLM aircraft.

Mats Ericson; Lena Mårtensson

116

The Fas Death Factor  

Microsoft Academic Search

Fas ligand (FasL), a cell surface molecule belonging to the tumor necrosis factor family, binds to its receptor Fas, thus inducing apoptosis of Fas-bearing cells. Various cells express Fas, whereas FasL is expressed predominantly in activated T cells. In the immune system, Fas and FasL are involved in down-regulation of immune reactions as well as in T cell-mediated cytotoxicity. Malfunction

Shigekazu Nagata; Pierre Golstein

1995-01-01

117

Factors Affecting Gummy Butter.  

E-print Network

LIBRARY A. & M. COLLEGE OF TEXAS Factors Affecting Gummy Butter DIGEST Among the Southcentral States, Texas ranks next to Oklahoma and Kentucky in creamery butter production; in farm butter production Texas is third in the nation... products produce I butter having what is known as a gummy or melt-resistant body. The availability and nutritive qualities of cottonseed products make them highly desirable as dairy feeds, especially in the South. This study shows that the gummy...

Leighton, R. E. (Rudolph Elmo); Moore, A. V.

1952-01-01

118

Factors Influencing Job Choice  

Microsoft Academic Search

This research sets out a Perceptual-Judgemental-Reinforcement approach to job choice under conditions of complexity and uncertainty.\\u000a It investigates the claim that job choices are based on seven implicit factors: such as the specific size of the occupation,\\u000a the proportion of employees working full-time, the earnings, the job prospects, gender dominance in an occupation, the level\\u000a of unemployment in the occupation

James A. Athanasou

2003-01-01

119

Factor Trail Game  

NSDL National Science Digital Library

In this math game, learners identify the factors of a number to earn points. The score sheet used for this game provides a built-in assessment tool that teachers can use to check their students' understanding. This game also provides an opportunity for cooperative learning--learners check one another's work before points are awarded. This lesson guide includes questions for learners, assessment options, extensions, and reflection questions.

G. Patrick Vennebush.

2008-01-01

120

R-Factor  

NSDL National Science Digital Library

The amount of energy used in a home is greatly impacted by the type of materials used in constructing the home. In particular, the thermal conductivity of the materials will affect how quickly heat is allowed to enter or leave the home. In this hands-on activity, students will measure the ability of various materials to resist heat flow (R-factor) by placing a light bulb inside boxes made of the materials and monitoring the temperatures both inside and outside.

Pratte, John

121

Risk Factors for Eating Disorders  

ERIC Educational Resources Information Center

The authors review research on risk factors for eating disorders, restricting their focus to studies in which clear precedence of the hypothesized risk factor over onset of the disorder is established. They illustrate how studies of sociocultural risk factors and biological factors have progressed on parallel tracks and propose that major advances…

Striegel-Moore, Ruth H.; Bulik, Cynthia M.

2007-01-01

122

Human Factors Review Plan  

SciTech Connect

''Human Factors'' is concerned with the incorporation of human user considerations into a system in order to maximize human reliability and reduce errors. This Review Plan is intended to assist in the assessment of human factors conditions in existing DOE facilities. In addition to specifying assessment methodologies, the plan describes techniques for improving conditions which are found to not adequately support reliable human performance. The following topics are addressed: (1) selection of areas for review describes techniques for needs assessment to assist in selecting and prioritizing areas for review; (2) human factors engineering review is concerned with optimizing the interfaces between people and equipment and people and their work environment; (3) procedures review evaluates completeness and accuracy of procedures, as well as their usability and management; (4) organizational interface review is concerned with communication and coordination between all levels of an organization; and (5) training review evaluates training program criteria such as those involving: trainee selection, qualification of training staff, content and conduct of training, requalification training, and program management.

Paramore, B.; Peterson, L.R. (eds.)

1985-12-01

123

Influence curves for factor loadings.  

PubMed

Influence curves for the initial and rotated loadings are derived for the maximum likelihood factor analysis (MLFA) model. Cook's distances based on the empirical influence curves of factor loadings are proposed for the identification of influential observations. The distances are shown to be invariant under scale transformation and factor rotation. We find that an observation with a very large Cook's distance based on the sample influence curve may not necessarily exert an excessive influence on the factor loadings pattern but may change the ordering of the factors. The issue of the switching of factors is also studied by means of the empirical influence curve and factor scores. PMID:16293205

Kwan, C W; Fung, W K

2005-11-01

124

Tissue factor and atherothrombosis.  

PubMed

Tissue factor (TF) is known to be the key element in the initiation of the extrinsic pathway of the coagulation cascade and appears to be a critical determinant of atherosclerotic plaque thrombogenicity. TF is needed to produce thrombin from prothrombin. In the extrinsic pathway, TF activates factor Vll. TF is expressed mainly on subendothelial tissues, but TF expression may be induced on endothelial cells by inflammatory mediators such as tumor necrosis factor-alpha (TNF-alpha). Subendothelial TF is responsible for initiating fibrin formation at sites of vascular injury, bloodborne TF may be an important contributor to propagation of the developing thrombus. It has been postulated that the blood-borne TF initiates the thrombogenic stimulus, leading to the formation of larger and more stable thrombus. TF may attach to cellular receptors, which in turn affect the production and release of inflammatory mediators. Baseline plasma TF activity has been demonstrated as an independent predictor for cardiovascular death in patients with acute myocardial infarction. TF is expressed by macrophage-derived foam cells in atherosclerotic plaques. TF levels were higher in atheroma from patients with unstable angina than with stable angina. These results suggest that high levels of TF exposed upon plaque rupture trigger atherothrombosis. Inhibition of TF would be expected to reduce thrombosis associated with a variety of diseases. TF pathway is a potential target for new therapeutic agents that can decrease TF activity, such as active site-inactivated factor VIIa, recombinant TF inhibitor and antibodies against TF or peptides interfering with TF-FVIIa complex activity. Significant clinical forms of atherosclerosis, such as sudden death, myocardial infarction, and stroke have common pathogenesis. The occlusion of the vessel lumen is the result from atherosclerotic plaque rupture/erosion that initiate thrombus formation. This thrombus has complex structure and contains predominantly fibrin in addition to platelets, suggesting an important role for the coagulation cascade in plaque thrombus formation. Tissue factor (TF) is known to be the key element in the initiation of the extrinsic pathway of the coagulation cascade and appears to be a critical determinant of atherosclerotic plaque thrombogenicity. PMID:25312727

Saha, D; S, Saha; Sergeeva, E G; Ionova, Z I; Gorbach, A V

2015-01-01

125

Polyphosphate accelerates factor V activation by factor XIa.  

PubMed

Factor Va enhances the rate of prothrombin activation by factor Xa by four to five orders of magnitude. Production of initiating levels of factor Va from its precursor, factor V, is a critical event early in haemostasis, as factor V exhibits negligible cofactor activity. While thrombin is the most potent physiological back-activator of factor V, the first prothrombinase complexes require a source of factor Va prior to thrombin generation. A recent study by Whelihan et al. (J Thromb Haemost 2010; 8:1532-1539) identified factor XIa as a candidate for the initial thrombin-independent activation of factor V, although this reaction was slow and required relatively high concentrations of factors V and XIa. Activated platelets secrete polyphosphate, which we previously showed to be potently procoagulant. We now report that polyphosphate greatly accelerates factor V activation by factor XIa, and that this is supported by polyphosphate polymers of the size secreted by activated human platelets. This finding provides additional evidence that factor XIa-mediated generation of factor Va may contribute to the initiation of haemostasis. PMID:25338662

Choi, S H; Smith, S A; Morrissey, J H

2015-03-01

126

Exploratory Bi-factor Analysis  

PubMed Central

Bi-factor analysis is a form of confirmatory factor analysis originally introduced by Holzinger. The bi-factor model has a general factor and a number of group factors. The purpose of this paper is to introduce an exploratory form of bi-factor analysis. An advantage of using exploratory bi-factor analysis is that one need not provide a specific bi-factor model a priori. The result of an exploratory bi-factor analysis, however, can be used as an aid in defining a specific bi-factor model. Our exploratory bi-factor analysis is simply exploratory factor analysis using a bi-factor rotation criterion. This is a criterion designed to produce perfect cluster structure in all but the first column of a rotated loading matrix. Examples are given to show how exploratory bi-factor analysis can be used with ideal and real data. The relation of exploratory bi-factor analysis to the Schmid-Leiman method is discussed. PMID:22232562

Jennrich, Robert I.; Bentler, Peter M.

2011-01-01

127

Neutron quality factor  

SciTech Connect

Both the International Commission on Radiological Protection (ICRP) and the National Council on Radiation Protection and Measurements (NCRP) have recommended that the radiation quality weighting factor for neutrons (Q{sub n}, or the corresponding new modifying factor, w{sub R}) be increased by a value of two for most radiation protection practices. This means an increase in the recommended value for Q{sub n} from a nominal value of 10 to a nominal value of 20. This increase may be interpreted to mean that the biological effectiveness of neutrons is two times greater than previously thought. A decision to increase the value of Q{sub n} will have a major impact on the regulations and radiation protection programs of Federal agencies responsible for the protection of radiation workers. Therefore, the purposes of this report are: (1) to examine the general concept of {open_quotes}quality factor{close_quotes} (Q) in radiation protection and the rationale for the selection of specific values of Q{sub n}; and (2) to make such recommendations to the Federal agencies, as appropriate. This report is not intended to be an exhaustive review of the scientific literature on the biological effects of neutrons, with the aim of defending a particular value for Q{sub n}. Rather, the working group examined the technical issues surrounding the current recommendations of scientific advisory bodies on this matter, with the aim of determining if these recommendations should be adopted by the Federal agencies. Ultimately, the group concluded that there was no compelling basis for a change in Q{sub n}. The report was prepared by Federal scientists working under the auspices of the Science Panel of the Committee on Interagency Radiation Research and Policy Coordination (CIRRPC).

NONE

1995-06-01

128

Nucleon elastic form factors  

SciTech Connect

The nucleon form factors are still the subject of active investigation even after an experimental effort spanning 50 years. This is because they are of critical importance to our understanding of the electromagnetic properties of nuclei and provide a unique testing ground for QCD motivated models of nucleon structure. Progress in polarized beams, polarized targets and recoil polarimetry have allowed an important and precise set of data to be collected over the last decade. I will review the experimental status of elastic electron scattering from the nucleon along with an outlook for future progress.

D. Day

2007-03-01

129

Cinco Ws e um H para o jornalismo na web  

Microsoft Academic Search

A influência da Internet nas mais diversas áreas de intervenção humana provocou alterações profundas nas rotinas profissionais e lúdicas dos cidadãos. No campo do jornalismo, a Internet influenciou fortemente a actividade profissional, permitindo ainda o aparecimento de um novo tipo de jornalismo comummente chamado ciberjornalismo, webjornalismo ou jornalismo digital. Embora as características deste novo tipo de jornalismo estejam perfeitamente identificadas

João Canavilhas

2008-01-01

130

?*?*??c transition form factor  

NASA Astrophysics Data System (ADS)

We study the ?*?*??c transition form factor, F?c??(Q12,Q22), with the local-duality (LD) version of QCD sum rules. We analyze the extraction of this quantity from two different correlators, ?PVV? and ?AVV?, with P, A, and V being the pseudoscalar, axial-vector, and vector currents, respectively. The QCD factorization theorem for F?c??(Q12,Q22) allows us to fix the effective continuum thresholds for the ?PVV? and ?AVV? correlators at large values of Q2=Q22 and some fixed value of ??Q12/Q22. We give arguments that, in the region Q2?10-15GeV2, the effective threshold should be close to its asymptotic value such that the LD sum rule provides reliable predictions for F?c??(Q12,Q22). We show that, for the experimentally relevant kinematics of one real and one virtual photon, the result of the LD sum rule for F?c?(Q2)?F?c??(0,Q2) may be well approximated by the simple monopole formula F?c?(Q2)=2ec2NcfP(MV2+Q2)-1, where fP is the ?c decay constant, ec2 is the c-quark charge, and the parameter MV lies in the mass range of the lowest c¯c vector states.

Lucha, Wolfgang; Melikhov, Dmitri

2012-07-01

131

Decryption of tissue factor  

PubMed Central

Tissue factor (TF) is a transmembrane protein which, in complex with factor (F)VIIa, initiates blood coagulation. Numerous studies have determined TF epitopes and individual amino acids which play an important role in the TF/FVIIa complex formation and its activity towards natural substrates. However the subject of cell-surface TF activity remains controversial. It has been almost commonly accepted that TF on the cell surface has low (if any) activity, i.e. is encrypted and requires specific conditions/reagents to become active, i.e. decrypted. One of the leading theories suggests that cell membrane lipid composition plays a crucial role in TF decryption, whereas another assigns the key role to the formation of the Cys186-Cys209 disulfide bond. Despite a number of studies published from several laboratories, the role of this bond in the activity of the TF/FVIIa complex remains elusive and controversial. One of the causes of this controversy could be related to the lack of specificity of the reagents used for the cell treatment leading to possible alterations in other cell surface proteins and cell membrane environment. In conclusion, the influence of the Cys186-Cys209 this bond on cell surface TF function remains unclear. PMID:22401800

Butenas, Saulius; Krudysz-Amblo, Jolanta

2012-01-01

132

SARSCEST (human factors)  

NASA Technical Reports Server (NTRS)

People interact with the processes and products of contemporary technology. Individuals are affected by these in various ways and individuals shape them. Such interactions come under the label 'human factors'. To expand the understanding of those to whom the term is relatively unfamiliar, its domain includes both an applied science and applications of knowledge. It means both research and development, with implications of research both for basic science and for development. It encompasses not only design and testing but also training and personnel requirements, even though some unwisely try to split these apart both by name and institutionally. The territory includes more than performance at work, though concentration on that aspect, epitomized in the derivation of the term ergonomics, has overshadowed human factors interest in interactions between technology and the home, health, safety, consumers, children and later life, the handicapped, sports and recreation education, and travel. Two aspects of technology considered most significant for work performance, systems and automation, and several approaches to these, are discussed.

Parsons, H. Mcilvaine

1988-01-01

133

Factor VII deficiency in pregnancy treated with recombinant factor VIIa  

Microsoft Academic Search

BACKGROUND:Factor VII deficiency is an autosomal recessive bleeding disorder with an incidence of one in 500,000. Few cases have been reported in pregnancy, and only two patients were treated with recombinant factor VIIa. In the past, fresh frozen plasma or factor VII concentrate has been the conventional treatment for this disorder.CASE:We report a case of factor VII deficiency diagnosed during

Niloofar Eskandari; Nancy Feldman; Jeffrey S Greenspoon

2002-01-01

134

Salivary Gland Cancer: Risk Factors  

MedlinePLUS

... Request Permissions Print to PDF Salivary Gland Cancer: Risk Factors Approved by the Cancer.Net Editorial Board , 04/ ... menu on the side of your screen. A risk factor is anything that increases a person’s chance of ...

135

View factor computer program (VIEW)  

NASA Technical Reports Server (NTRS)

Existing view factor program, RAVFAC, was modified to accept NASTRAN and/or RAVFAC surface descriptions. Output formatting was altered to produce view factor matrices which could be directly input to NASTRAN.

Jackson, C. E., Jr.; Puccinelli, E. F.

1975-01-01

136

Environmental factors and aggressive behavior  

SciTech Connect

This paper briefly reviews some of the research areas which indicate a correlation between environmental factors and initiation of aggressive behavior. Environmental factors including lunar influences, month of birth, climate and the effects of crowding and certain chemicals are discussed.

Anderson, A.C.

1982-07-01

137

Modifiable Risk Factors Branch (MRFB)  

Cancer.gov

The Modifiable Risk Factors Branch (MRFB) focuses on factors to reduce cancer risk in humans, including exposures to nutritional components; physical activity and energy balance; alcohol and tobacco; and infectious, physical, and chemical agents.

138

Aluminum Wash and Leach Factors  

SciTech Connect

This report estimates aluminum wash and leach factors using a waste type modeling approach. The model produces reasonable aluminum wash-leach factor predictions that can be used in the Hanford Tank Waste Operations Simulator model.

MEACHAM, J.E.

2003-07-10

139

Nucleon Electromagnetic Form Factors  

SciTech Connect

There has been much activity in the measurement of the elastic electromagnetic proton and neutron form factors in the last decade, and the quality of the data has greatly improved by performing double polarization experiments, in comparison with previous unpolarized data. Here we review the experimental data base in view of the new results for the proton, and neutron, obtained at JLab, MAMI, and MIT-Bates. The rapid evolution of phenomenological models triggered by these high-precision experiments will be discussed, including the recent progress in the determination of the valence quark generalized parton distributions of the nucleon, as well as the steady rate of improvements made in the lattice QCD calculations.

Marc Vanderhaeghen; Charles Perdrisat; Vina Punjabi

2007-10-01

140

Psychosomatic factors in pruritus.  

PubMed

Pruritus and psyche are intricately and reciprocally related, with psychophysiological evidence and psychopathological explanations helping us to understand their complex association. Their interaction may be conceptualized and classified into 3 groups: pruritic diseases with psychiatric sequelae, pruritic diseases aggravated by psychosocial factors, and psychiatric disorders causing pruritus. Management of chronic pruritus is directed at treating the underlying causes and adopting a multidisciplinary approach to address the dermatologic, somatosensory, cognitive, and emotional aspects. Pharmcotherapeutic agents that are useful for chronic pruritus with comorbid depression and/or anxiety comprise selective serotonin reuptake inhibitors, mirtazapine, tricyclic antidepressants (amitriptyline and doxepin), and anticonvulsants (gabapentin, pregabalin); the role of neurokinin receptor-1 antagonists awaits verification. Antipsychotics are required for treating itch and formication associated with schizophrenia and delusion of parasitosis (including Morgellons disease). PMID:23245971

Tey, Hong Liang; Wallengren, Joanna; Yosipovitch, Gil

2013-01-01

141

Unity power factor converter  

NASA Technical Reports Server (NTRS)

A unity power factor converter capable of effecting either inversion (dc-to-dc) or rectification (ac-to-dc), and capable of providing bilateral power control from a DC source (or load) through an AC transmission line to a DC load (or source) for power flow in either direction, is comprised of comparators for comparing the AC current i with an AC signal i.sub.ref (or its phase inversion) derived from the AC ports to generate control signals to operate a switch control circuit for high speed switching to shape the AC current waveform to a sine waveform, and synchronize it in phase and frequency with the AC voltage at the AC ports, by selectively switching the connections to a series inductor as required to increase or decrease the current i.

Wester, Gene W. (Inventor)

1980-01-01

142

Exposure factors handbook  

SciTech Connect

The document provides a summary of the available data on various factors used in assessing human exposure including drinking-water consumption, consumption rates of broad classes of food including fruits, vegetables, beef, dairy products, and fish; soil ingestion; inhalation rate; skin area; lifetime; activity patterns; and body weight. Additionally, a number of specific exposure scenarios are identified with recommendations for default values to use when site-specific data are not available. The basic equations using these parameters to calculate exposure levels are also presented for each scenario. Default values are presented as ranges from typical to reasonable worst case and as frequency distributions where appropriate data were available. Finally, procedures for assessing the uncertainties in exposure assessments are also presented with illustrative examples. These procedures include qualitative and quantitative methods such as Monte Carlo and sensitivity analysis.

Konz, J.J.; Lisi, K.; Friebele, E.; Dixon, D.A.

1989-07-01

143

Physical Activity and Anthropometric Factors  

Microsoft Academic Search

\\u000a Physical activity and certain anthropometric factors have been proposed as independent risk factors for breast cancer. Increased\\u000a physical activity appears to be associated with decreased breast cancer risk, and this association is independent of the influence\\u000a of anthropometric factors on risk. Conversely, anthropometric factors such as body mass index (BMI), weight change, and height\\u000a appear to have effects on breast

Katherine D. Henderson; Jennifer Prescott; Leslie Bernstein

144

Helicopter Human Factors  

NASA Technical Reports Server (NTRS)

Even under optimal conditions, helicopter flight is a most demanding form of human-machine interaction, imposing continuous manual, visual, communications, and mental demands on pilots. It is made even more challenging by small margins for error created by the close proximity of terrain in NOE flight and missions flown at night and in low visibility. Although technology advances have satisfied some current and proposed requirements, hardware solutions alone are not sufficient to ensure acceptable system performance and pilot workload. However, human factors data needed to improve the design and use of helicopters lag behind advances in sensor, display, and control technology. Thus, it is difficult for designers to consider human capabilities and limitations when making design decisions. This results in costly accidents, design mistakes, unrealistic mission requirements, excessive training costs, and challenge human adaptability. NASA, in collaboration with DOD, industry, and academia, has initiated a program of research to develop scientific data bases and design principles to improve the pilot/vehicle interface, optimize training time and cost, and maintain pilot workload and system performance at an acceptable level. Work performed at Ames, and by other research laboratories, will be reviewed to summarize the most critical helicopter human factors problems and the results of research that has been performed to: (1) Quantify/model pilots use of visual cues for vehicle control; (2) Improve pilots' performance with helmet displays of thermal imagery and night vision goggles for situation awareness and vehicle control; (3) Model the processes by which pilots encode maps and compare them to the visual scene to develop perceptually and cognitively compatible electronic map formats; (4) Evaluate the use of spatially localized auditory displays for geographical orientation, target localization, radio frequency separation; (5) Develop and flight test control/display concepts; (6) Quantify, model, predict, and improve pilots, workload-management strategies; and (7) Design computer-game trainers to reduce training time and cost.

Hart, Sandra G.; Sridhar, Banavar (Technical Monitor)

1995-01-01

145

Anthrax lethal factor inhibition  

PubMed Central

The primary virulence factor of Bacillus anthracis is a secreted zinc-dependent metalloprotease toxin known as lethal factor (LF) that is lethal to the host through disruption of signaling pathways, cell destruction, and circulatory shock. Inhibition of this proteolytic-based LF toxemia could be expected to provide therapeutic value in combination with an antibiotic during and immediately after an active anthrax infection. Herein is shown the crystal structure of an intimate complex between a hydroxamate, (2R)-2-[(4-fluoro-3-methylphenyl)sulfonylamino]-N-hydroxy-2-(tetrahydro-2H-pyran-4-yl)acetamide, and LF at the LF-active site. Most importantly, this molecular interaction between the hydroxamate and the LF active site resulted in (i) inhibited LF protease activity in an enzyme assay and protected macrophages against recombinant LF and protective antigen in a cell-based assay, (ii) 100% protection in a lethal mouse toxemia model against recombinant LF and protective antigen, (iii) ?50% survival advantage to mice given a lethal challenge of B. anthracis Sterne vegetative cells and to rabbits given a lethal challenge of B. anthracis Ames spores and doubled the mean time to death in those that died in both species, and (iv) 100% protection against B. anthracis spore challenge when used in combination therapy with ciprofloxacin in a rabbit “point of no return” model for which ciprofloxacin alone provided 50% protection. These results indicate that a small molecule, hydroxamate LF inhibitor, as revealed herein, can ameliorate the toxemia characteristic of an active B. anthracis infection and could be a vital adjunct to our ability to combat anthrax. PMID:15911756

Shoop, W. L.; Xiong, Y.; Wiltsie, J.; Woods, A.; Guo, J.; Pivnichny, J. V.; Felcetto, T.; Michael, B. F.; Bansal, A.; Cummings, R. T.; Cunningham, B. R.; Friedlander, A. M.; Douglas, C. M.; Patel, S. B.; Wisniewski, D.; Scapin, G.; Salowe, S. P.; Zaller, D. M.; Chapman, K. T.; Scolnick, E. M.; Schmatz, D. M.; Bartizal, K.; MacCoss, M.; Hermes, J. D.

2005-01-01

146

Factors facilitating construction industry development  

Microsoft Academic Search

The key factors associated with construction industry development worldwide are identified by using a grounded theory approach. This first involved the identification of 62 variables from earlier studies. A questionnaire survey was then used to elicit views of the current strength of each variable. The resulting data were factor analysed and a set of eight key factors obtained comprising the

Paul Fox; Martin Skitmore

2007-01-01

147

FACTOR FINDER CD-ROM  

EPA Science Inventory

The Factor Finder CD-ROM is a user-friendly, searchable tool used to locate exposure factors and sociodemographic data for user-defined populations. Factor Finder improves the exposure assessors and risk assessors (etc.) ability to efficiently locate exposure-related informatio...

148

Phonological Awareness: Factors of Influence  

ERIC Educational Resources Information Center

Early child development is influenced by various genetic and environmental factors. This study aims to identify factors that affect the phonological awareness of preschool and first grade children. Based on a sample of 330 German-speaking children (mean age = 6.2 years) the following domains were evaluated: Parent factors, birth and pregnancy,…

Frohlich, Linda Paulina; Petermann, Franz; Metz, Dorothee

2013-01-01

149

Productivity factors and programming environments  

Microsoft Academic Search

Fourteen factors that influence the efficiency of programming projects were identified in a corporate-wide study of 44 ITT programming projects in nine countries. Productivity factors were classified according to project management's ability to control them. Product-related factors are not generally under the control of project management. They describe intrinsic properties of the programming product and tend to place limitations on

Bill Curtis; R. Wolverton; B. Albert; H. Malec; S. Hoben; Y. Liu

1984-01-01

150

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current Shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. Training efforts in FY07 strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center operations. Beginning in January 2008, the training research effort will include team training prototypes and tools. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: 1) Risk associated with poor task design; 2) Risk of error due to inadequate information; 3) Risk associated with reduced safety and efficiency due to poor human factors design.

Barshi, Immanuel; Byme, Vicky; Arsintescu, Lucia

2008-01-01

151

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. By researching established training principles, examining future needs, and by using current practices in space flight training as test beds, both in Flight Controller and Crew Medical domains, this research project is mitigating program risks and generating templates and requirements to meet future training needs. Training efforts in Fiscal Year 09 (FY09) strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center (MCC) operations. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: 1) Risk associated with poor task design; 2) Risk of error due to inadequate information; and 3) Risk associated with reduced safety and efficiency due to poor human factors design.

Barshi, Immanuel; Byrne, Vicky; Arsintescu, Lucia; Connell, Erin

2010-01-01

152

Human Factors in Training  

NASA Technical Reports Server (NTRS)

Future space missions will be significantly longer than current shuttle missions and new systems will be more complex than current systems. Increasing communication delays between crews and Earth-based support means that astronauts need to be prepared to handle the unexpected on their own. As crews become more autonomous, their potential span of control and required expertise must grow to match their autonomy. It is not possible to train for every eventuality ahead of time on the ground, or to maintain trained skills across long intervals of disuse. To adequately prepare NASA personnel for these challenges, new training approaches, methodologies, and tools are required. This research project aims at developing these training capabilities. By researching established training principles, examining future needs, and by using current practices in space flight training as test beds, both in Flight Controller and Crew Medical domains, this research project is mitigating program risks and generating templates and requirements to meet future training needs. Training efforts in Fiscal Year 08 (FY08) strongly focused on crew medical training, but also began exploring how Space Flight Resource Management training for Mission Operations Directorate (MOD) Flight Controllers could be integrated with systems training for optimal Mission Control Center (MCC) operations. The Training Task addresses Program risks that lie at the intersection of the following three risks identified by the Project: (1) Risk associated with poor task design (2) Risk of error due to inadequate information (3) Risk associated with reduced safety and efficiency due to poor human factors design

Barshi, Immanuel; Byrne, Vicky; Arsintescu, Lucia; Connell, Erin; Sandor, Aniko

2009-01-01

153

Risk factors for periodontal disease.  

PubMed

Risk factors play an important role in an individual's response to periodontal infection. Identification of these risk factors helps to target patients for prevention and treatment, with modification of risk factors critical to the control of periodontal disease. Shifts in our understanding of periodontal disease prevalence, and advances in scientific methodology and statistical analysis in the last few decades, have allowed identification of several major systemic risk factors for periodontal disease. The first change in our thinking was the understanding that periodontal disease is not universal, but that severe forms are found only in a portion of the adult population who show abnormal susceptibility. Analysis of risk factors and the ability to statistically adjust and stratify populations to eliminate the effects of confounding factors have allowed identification of independent risk factors. These independent but modifiable, risk factors for periodontal disease include lifestyle factors, such as smoking and alcohol consumption. They also include diseases and unhealthy conditions such as diabetes mellitus, obesity, metabolic syndrome, osteoporosis, and low dietary calcium and vitamin D. These risk factors are modifiable and their management is a major component of the contemporary care of many periodontal patients. Genetic factors also play a role in periodontal disease and allow one to target individuals for prevention and early detection. The role of genetic factors in aggressive periodontitis is clear. However, although genetic factors (i.e., specific genes) are strongly suspected to have an association with chronic adult periodontitis, there is as yet no clear evidence for this in the general population. It is important to pursue efforts to identify genetic factors associated with chronic periodontitis because such factors have potential in identifying patients who have a high susceptibility for development of this disease. Many of the systemic risk factors for periodontal disease, such as smoking, diabetes and obesity, and osteoporosis in postmenopausal women, are relatively common and can be expected to affect most patients with periodontal disease seen in clinics and dental practices. Hence, risk factor identification and management has become a key component of care for periodontal patients. PMID:23574464

Genco, Robert J; Borgnakke, Wenche S

2013-06-01

154

Growth factors in ischemic stroke  

PubMed Central

Abstract Data from pre-clinical and clinical studies provide evidence that colony-stimulating factors (CSFs) and other growth factors (GFs) can improve stroke outcome by reducing stroke damage through their anti-apoptotic and anti-inflammatory effects, and by promoting angiogenesis and neurogenesis. This review provides a critical and up-to-date literature review on CSF use in stroke. We searched for experimental and clinical studies on haemopoietic GFs such as granulocyte CSF, erythropoietin, granulocyte-macrophage colony-stimulating factor, stem cell factor (SCF), vascular endothelial GF, stromal cell-derived factor-1? and SCF in ischemic stroke. We also considered studies on insulin-like growth factor-1 and neurotrophins. Despite promising results from animal models, the lack of data in human beings hampers efficacy assessments of GFs on stroke outcome. We provide a comprehensive and critical view of the present knowledge about GFs and stroke, and an overview of ongoing and future prospects. PMID:20015202

Lanfranconi, S; Locatelli, F; Corti, S; Candelise, L; Comi, G P; Baron, P L; Strazzer, S; Bresolin, N; Bersano, A

2011-01-01

155

Factoring polynomials with rational coefficients  

Microsoft Academic Search

In this paper we present a polynomial-time algorithm to solve the following problem: given a non-zero polynomial fe Q(X) in one variable with rational coefficients, find the decomposition of f into irreducible factors in Q(X). It is well known that this is equivalent to factoring primitive polynomials feZ(X) into irreducible factors in Z(X). Here we call f~ Z(X) primitive if

A. K. Lenstra; H. W. Lenstra; L. Lovfiasz

1982-01-01

156

Sexual Harassment: Identifying Risk Factors  

Microsoft Academic Search

A new model of the etiology of sexual harassment,the four-factor model, is presented and compared with several models of sexual harassment including the biological model, the organizational model, the sociocultural model,and the sexrole spillover model. A number of risk factors associated with sexually harassing behavior are examined within the framework of the four-factor model of sexual harassment. These include characteristics

Elizabeth A. O'Hare; William O'Donohue

1998-01-01

157

Five Describing Factors of Dyslexia.  

PubMed

Two subtypes of dyslexia (phonological, visual) have been under debate in various studies. However, the number of symptoms of dyslexia described in the literature exceeds the number of subtypes, and underlying relations remain unclear. We investigated underlying cognitive features of dyslexia with exploratory and confirmatory factor analyses. A sample of 446 students (63 with dyslexia) completed a large test battery and a large questionnaire. Five factors were found in both the test battery and the questionnaire. These 10 factors loaded on 5 latent factors (spelling, phonology, short-term memory, rhyme/confusion, and whole-word processing/complexity), which explained 60% of total variance. Three analyses supported the validity of these factors. A confirmatory factor analysis fit with a solution of five factors (RMSEA = .03). Those with dyslexia differed from those without dyslexia on all factors. A combination of five factors provided reliable predictions of dyslexia and nondyslexia (accuracy >90%). We also looked for factorial deficits on an individual level to construct subtypes of dyslexia, but found varying profiles. We concluded that a multiple cognitive deficit model of dyslexia is supported, whereas the existence of subtypes remains unclear. We discussed the results in relation to advanced compensation strategies of students, measures of intelligence, and various correlations within groups of those with and without dyslexia. PMID:25398549

Tamboer, Peter; Vorst, Harrie C M; Oort, Frans J

2014-11-14

158

A second-order factor analysis of critical TQM factors  

Microsoft Academic Search

The quality management literature prescribes various critical quality improvement strategies. However, there have been few empirical studies that tested for the synergy or the relationships among these critical quality constructs. This study develops a second-order factor model to test whether a set of critical quality management factors load on an overall construct that may be termed “Total quality management”. Using

Nabil Tamimi

1998-01-01

159

Growth factors and antimicrobial factors of bovine colostrum  

Microsoft Academic Search

Colostrum is the first natural food produced by female mammals during the first 24–36h directly after giving birth. Chemically, colostrum is a very complex fluid rich in nutrients, antibodies and growth factors. In cows the antibodies provide passive immunity to the new born calf, whereas the growth factors especially stimulate the growth of the gut. The other antimicrobial components of

R. Pakkanen; J. Aalto

1997-01-01

160

Detect and Track Latent Factors with Online Nonnegative Matrix Factorization  

Microsoft Academic Search

Detecting and tracking latent factors from tempo- ral data is an important task. Most existing algo- rithms for latent topic detection such as Nonneg- ative Matrix Factorization (NMF) have been de- signed for static data. These algorithms are unable to capture the dynamic nature of temporally chang- ing data streams. In this paper, we put forward an online NMF (ONMF)

Bin Cao; Dou Shen; Jian-tao Sun; Xuanhui Wang; Qiang Yang; Zheng Chen

2007-01-01

161

Factors That Influence Teacher Attrition.  

ERIC Educational Resources Information Center

External, employment, and personal factors which influence teacher decisions to stay, leave, or transfer from teaching assignments are discussed, with emphasis on special education teachers. Factors attributed to teacher attrition in urban and rural environments also are briefly reviewed, along with attrition of related services professionals.…

Gonzalez, Patricia

1995-01-01

162

Safety factors in bone strength  

Microsoft Academic Search

Summary Functionalin vivo strain data are examined in relation to bone material properties in an attempt to evaluate the relative importance of osteoporotic bone loss versus fatigue damage accumulation as factors underlying clinical bone fragility. Specifically, does the skeleton have a sufficiently large safety factor (ratio of bone failure strain to maximum functional strain) to require that fatigue damage accumulation

Andrew A. Biewener

1993-01-01

163

Cruise ship port planning factors  

Microsoft Academic Search

The predictions contained within this dissertation suggest further rapid growth of the cruise industry and the requirement for additional cruise ship berthing worldwide. The factors leading to the tremendous growth in the cruise marketplace are identified and individually addressed. Unfortunately, planning factors associated with the design and construction of cruise ship seaports are not readily available and methods to manage

Jeth Al Fogg

2001-01-01

164

Risk factors for prostate cancer  

Microsoft Academic Search

The incidence of prostate cancer continues to increase in the US. Compared with other common cancers such as those of the breast and lung, the causes of prostate cancer remain poorly understood. Research endeavors continue to identify predictors of risk for prostate cancer, of which familial and genetic factors are among the strongest. Known risk factors can show significant heterogeneity

Amit R Patel; Eric A Klein

2009-01-01

165

Escape from the impact factor  

Microsoft Academic Search

As Editor-in-Chief of the journal Nature, I am concerned by the tendency within acade- mic administrations to focus on a journal's impact factor when judging the worth of scientific contri- butions by researchers, affecting promotions, recruitment and, in some countries, financial bonuses for each paper. Our own internal research demonstrates how a high journal impact factor can be the skewed

Philip Campbell

2008-01-01

166

Oncogenes, genes, and growth factors  

SciTech Connect

This book contains 12 chapters. Some of the chapter titles are: The Epidermal Growth Factor Receptor Gene; Structure and Expression of the Nerve Growth Factor Gene; The Erythropoietin Gene; The Interleukin-2 Gene; The Transferrin Gene; and The Transferrin Receptor Gene.

Guroff, G.

1989-01-01

167

Smoking – A Renal Risk Factor  

Microsoft Academic Search

One of the most important tasks of clinical and experimental nephrology is to identify the risk factors of progression of renal failure. A major renal risk factor which has not been sufficiently acknowledged despite increasing evidence is cigarette smoking. Diabetologists were the first to recognize the adverse effects of smoking on the kidney: both in type 1 and in type

Stephan R. Orth

2000-01-01

168

Human factors in mission assurance  

NASA Technical Reports Server (NTRS)

Space projects rely completely on people for development and implementation - but project-related risk list rarely include human factors as significant sources of risk. The paper notes mitigation techniques for risks associated with the human factors - readers are encouraged to come up with as many mitigation strategies as possible, and share them with each other.

Baroff, L. E.

2003-01-01

169

Glucocorticoid-regulated Transcription Factors  

Microsoft Academic Search

Glucocorticoids are the most effective antiinflammatory drugs used in the treatment of asthma. They act by binding to a specific receptor (GR) that, upon activation, translocates to the nucleus and either increases (transactivates) or decreases (transrepresses) gene expression. Inhibition of pro-inflammatory transcription factors such as activator protein (AP)-1, signal transducers and activators of transcription (STATs), nuclear factor of activated T

I. M. Adcock

2001-01-01

170

Factors affecting sorghum protein digestibility  

Microsoft Academic Search

In the semi-arid tropics worldwide, sorghum (Sorghum bicolor (L.) Moench) is cultivated by farmers on a subsistence level and consumed as food by humans. A nutritional limitation to its use is the poor digestibility of sorghum protein when wet cooked. The factors affecting wet cooked sorghum protein digestibility may be categorised into two main groups: exogenous factors (grain organisational structure,

K. G Duodu; J. R. N Taylor; P. S Belton; B. R Hamaker

2003-01-01

171

Optimizing human factors in dentistry  

PubMed Central

Occupational health hazards among dental professionals are on a continuous rise and they have a significant negative overall impact on daily life. This review is intended to provide the information regarding risk factors and to highlight the prevention strategies for optimizing human factors in dentistry. Risk factors among dentists are multifactorial, which can be categorized into biomechanical and psychosocial. To achieve a realistic target of safety and health at work, prevention is clearly the best approach; therefore, musculoskeletal disorders can be reduced through proper positioning of dental worker and patient, regular rest breaks, general good health, using ergonomic equipment, and exercises designed to counteract the particular risk factors for the dental occupation. However, substantial evidences are still required to elucidate the potential risk factors and to formulate effective prevention programs. PMID:23946745

Gupta, Arpit; Ankola, Anil V.; Hebbal, Mamata

2013-01-01

172

Great Lakes management: Ecological factors  

NASA Astrophysics Data System (ADS)

Although attempts to improve the quality of the Great Lakes generally focus on chemical pollution, other factors are important and should be considered Ecological factors, such as invasion of the lakes by foreign species, habitat changes, overfishing, and random variations in organism populations, are especially influential. Lack of appreciation of the significance of ecological factors stems partly from the inappropriate application of the concept of eutrophication to the Great Lakes. Emphasis on ecological factors is not intended to diminish the seriousness of pollution, but rather to point out that more cost-effective management, as well as more realistic expectations of management efforts by the public, should result from an ecosystem management approach in which ecological factors are carefully considered.

Sonzogni, W. C.; Robertson, A.; Beeton, A. M.

1983-11-01

173

Transcription factors, chromatin and cancer.  

PubMed

Transcription factors, chromatin and chromatin-modifying enzymes are key components in a complex network through which the genome interacts with its environment. For many transcription factors, binding motifs are found adjacent to the promoter regions of a large proportion of genes, requiring mechanisms that confer binding specificity in any given cell type. These include association of the factor with other proteins and packaging of DNA, as chromatin, at the binding sequence so as to inhibit or facilitate binding. Recent evidence suggests that specific post-translational modifications of the histones packaging promoter DNA can help guide transcription factors to selected sites. The enzymes that put such modifications in place are dependent on metabolic components (e.g. acetyl CoA, S-adenosyl methionine) and susceptible to inhibition or activation by environmental factors. Local patterns of histone modification can be altered or maintained through direct interaction between the transcription factor and histone modifying enzymes. The functional consequences of transcription factor binding are also dependent on protein modifying enzymes, particularly those that alter lysine methylation at selected residues. Remarkably, the role of these enzymes is not limited to promoter-proximal events, but can be linked to changes in the intranuclear location of target genes. In this review we describe results that begin to define how transcription factors, chromatin and environmental variables interact and how these interactions are subverted in cancer. We focus on the nuclear receptor family of transcription factors, where binding of ligands such as steroid hormones and dietary derived factors provides an extra level of environmental input. PMID:18804550

Thorne, James L; Campbell, Moray J; Turner, Bryan M

2009-01-01

174

Using Bayes factors for multi-factor, biometric authentication  

NASA Astrophysics Data System (ADS)

Multi-factor/multi-modal authentication systems are becoming the de facto industry standard. Traditional methods typically use rates that are point estimates and lack a good measure of uncertainty. Additionally, multiple factors are typically fused together in an ad hoc manner. To be consistent, as well as to establish and make proper use of uncertainties, we use a Bayesian method that will update our estimates and uncertainties as new information presents itself. Our algorithm compares competing classes (such as genuine vs. imposter) using Bayes Factors (BF). The importance of this approach is that we not only accept or reject one model (class), but compare it to others to make a decision. We show using a Receiver Operating Characteristic (ROC) curve that using BF for determining class will always perform at least as well as the traditional combining of factors, such as a voting algorithm. As the uncertainty decreases, the BF result continues to exceed the traditional methods result.

Giffin, A.; Skufca, J. D.; Lao, P. A.

2015-01-01

175

Development of stress intensification factors  

SciTech Connect

B31.1 Equation 13A, B31.3 Equation 18, and Section 3 Paragraphs NC/ND-3653 EQS. (10), (10a), and 11 all use i-factors (SIFs) to compute stresses in piping due to displacement induced loadings. Appendix D of the B31 Standards and Figure NC/ND-3673.2(b)-1 of Section 3 give values of i-factors for commonly used piping components. A need occasionally arises to establish i-factors for other components (e.g., a branch connection in an elbow). In order to provide guidance on the development of these factors, a new draft Appendix has been prepared to assure that the experimental procedures and interpretation of the test results leading to new i-factors are consistent with the basis for existing i-factors. This paper discusses the background to the proposed Appendix, using the Section 3 version as a model, and also provides the authors` opinions an the need for experimental verification (vs purely analytical computation) of i-factors. The Appendix proposed is to be part of Appendix 2 of Section 3.

Minichiello, J.C. [VECTRA Technologies, Inc., Naperville, IL (United States); Rodabaugh, E.C.

1995-12-01

176

Environmental risk factors for autism  

PubMed Central

Autism is a devastating childhood condition that has emerged as an increasing social concern just as it has increased in prevalence in recent decades. Autism and the broader category of autism spectrum disorders are among the increasingly seen examples in which there is a fetal basis for later disease or disorder. Environmental, genetic, and epigenetic factors all play a role in determining the risk of autism and some of these effects appear to be transgenerational. Identification of the most critical windows of developmental vulnerability is paramount to understanding when and under what circumstances a child is at elevated risk for autism. No single environmental factor explains the increased prevalence of autism. While a handful of environmental risk factors have been suggested based on data from human studies and animal research, it is clear that many more, and perhaps the most significant risk factors, remain to be identified. The most promising risk factors identified to date fall within the categories of drugs, environmental chemicals, infectious agents, dietary factors, and other physical/psychological stressors. However, the rate at which environmental risk factors for autism have been identified via research and safety testing has not kept pace with the emerging health threat posed by this condition. For the way forward, it seems clear that additional focused research is needed. But more importantly, successful risk reduction strategies for autism will require more extensive and relevant developmental safety testing of drugs and chemicals. PMID:24149029

Dietert, Rodney R.; Dietert, Janice M.; Dewitt, Jamie C.

2010-01-01

177

Characterization of Novel Forms of Coagulation Factor XIa: independence of factor XIa subunits in factor IX activation.  

PubMed

Factor XI is the zymogen of a dimeric plasma protease, factor XIa, with two active sites. In solution, and during contact activation in plasma, conversion of factor XI to factor XIa proceeds through an intermediate with one active site (1/2-FXIa). Factor XIa and 1/2-FXIa activate the substrate factor IX, with similar kinetic parameters in purified and plasma systems. During hemostasis, factor IX is activated by factors XIa or VIIa, by cleavage of the peptide bonds after Arg145 and Arg180. Factor VIIa cleaves these bonds sequentially, with accumulation of factor IX alpha, an intermediate cleaved after Arg145. Factor XIa also cleaves factor IX preferentially after Arg145, but little intermediate is detected. It has been postulated that the two factor XIa active sites cleave both factor IX peptide bonds prior to releasing factor IX abeta. To test this, we examined cleavage of factor IX by four single active site factor XIa proteases. Little intermediate formation was detected with 1/2-FXIa, factor XIa with one inhibited active site, or a recombinant factor XIa monomer. However, factor IX alpha accumulated during activation by the factor XIa catalytic domain, demonstrating the importance of the factor XIa heavy chain. Fluorescence titration of active site-labeled factor XIa revealed a binding stoichiometry of 1.9 +/- 0.4 mol of factor IX/mol of factor XIa (Kd = 70 +/- 40 nm). The results indicate that two forms of activated factor XI are generated during coagulation, and that each half of a factor XIa dimer behaves as an independent enzyme with respect to factor IX. PMID:18192270

Smith, Stephen B; Verhamme, Ingrid M; Sun, Mao-fu; Bock, Paul E; Gailani, David

2008-03-14

178

Risk factors for equine laminitis  

E-print Network

logistic regression to assess age, breed, sex, and seasonality as risk factors for equine laminitis. There were 70 acute cases, 183 chronic cases, and 779 controls. No statistical association was found between age, breed, sex, or seasonality...

Polzer, John Patrick

1995-01-01

179

Hierarchical Regression without Phantom Factors.  

ERIC Educational Resources Information Center

Shows that phantom factors are unnecessary to achieve the objectives of a hierarchical regression and gives a direct approach to computing hierarchical or fixed-order regressions that is equivalent to that proposed by P. de Jong (1999).(SLD)

Bentler, Peter M.; Satorra, Albert

2000-01-01

180

Automatic Test Factoring for Java  

E-print Network

Test factoring creates fast, focused unit tests from slow system-widetests; each new unit test exercises only a subset of the functionalityexercised by the system test. Augmenting a test suite with factoredunit tests ...

Saff, David

2005-06-08

181

Predisposition Factors in Anorexia Nervosa.  

ERIC Educational Resources Information Center

Reviews literature concerned with investigating psychiatric disturbances and genetic variables hypothesized as predisposing factors in etiology of anorexia nervosa. Gives particular emphasis to research which discusses association between anorexia nervosa and depression. Reviews psychopharmacological evidence and family genetics studies. Offers…

Nagel, K. L.; Jones, Karen H.

1992-01-01

182

What Are the Risk Factors?  

MedlinePLUS

... Cancer Home What Are the Risk Factors for Lung Cancer? Language: English Español (Spanish) Recommend on Facebook Tweet ... those who smoke. Personal or Family History of Lung Cancer If you are a lung cancer survivor, there ...

183

What Factors Impact a Greenhouse?  

NSDL National Science Digital Library

This activity has students use a model to investigate factors in greenhouse heating and cooling. The type of surface that sunlight first encounters is the most important factor. Forests, grasslands, ocean surfaces, ice caps, deserts, and cities all absorb, reflect, and radiate radiation differently. As a result of this activity students will be able to identify at least three factors affecting the heat-trapping ability of a greenhouse, explain the factors important in the atmosphere's heat trapping ability, and understand the influence of albedo on earth's temperature. The student guide has an overall description of the activity, a list of materials, the procedure, and observations and questions. The instructor guide contains detailed background material, learning goals, alignment to national standards, grade level/time, details on materials and preparation, procedure, assessment ideas, and modifications for alternative learners.

184

Human Factors In Aircraft Automation  

NASA Technical Reports Server (NTRS)

Report presents survey of state of art in human factors in automation of aircraft operation. Presents examination of aircraft automation and effects on flight crews in relation to human error and aircraft accidents.

Billings, Charles

1995-01-01

185

Chemical Specific Adjustment factors Workshop  

EPA Science Inventory

The World Health Organization, through the International Programme on Chemical Safety (IPCS), has established guidance on the use of mechanistic data to replace default uncertainty factors for interspecies extrapolation and intraspecies variability in deriving risk values such as...

186

Formulas for Image Factor Scores  

ERIC Educational Resources Information Center

Formulas are presented in this paper for computing scores associated with factors of G, the image covariance matrix, under three conditions. The subject of the paper is restricted to "pure" image analysis. (Author/NE)

Hakstian, A. Ralph

1973-01-01

187

Overlooked factors prolong EMS payback  

Microsoft Academic Search

Projected payback of Andover Controls energy-management system at the University of New Hampshire has nearly doubled because of factors school officials overlooked, such as poor insulation in electrically heated dormitories and employee use of portable space heaters.

Barber

1983-01-01

188

Risk factors for pathological gambling  

Microsoft Academic Search

To better understand pathological gambling, potential risk factors were assessed within three domains—gambling behaviors, substance abuse and other problem behaviors, and sociodemographic factors. A random-digit-dial telephone survey was conducted in 1999–2000 with a representative sample of the U.S. population aged 18 or older. The current analyses uses data from the 2168 respondents who gambled in the year before the interview.

John W. Welte; Grace M. Barnes; William F. Wieczorek; Marie-Cecile O. Tidwell; John C. Parker

2004-01-01

189

Clotting factors VIII and IX  

Microsoft Academic Search

\\u000a Haemophilia is the most common congenital disorder of coagulation and affects approximately 1 in 10,000 males around the world.\\u000a Haemophilia A is due to a deficiency of factor VIII in the circulating blood whilst haemophilia B (also known as Christmas\\u000a disease) is a clinically identical disorder caused by factor IX deficiency. It is less common than haemophilia A and affects

George G. Brownlee; Paul L. F. Giangrande

190

Structure of human factor VIII  

Microsoft Academic Search

The deduced amino acid sequence of human factor VIII, obtained from the DNA sequence, predicts a mature polypeptide of 2,332 amino acids containing a triplicated domain structure. The polypeptide has 35% sequence homology with the copper-binding plasma protein, ceruloplasmin. Determination of the thrombin cleavage sites in plasma-derived factor VIII polypeptides allows prediction of the domains involved in the associated activation

Gordon A. Vehar; Bruce Keyt; Dan Eaton; Henry Rodriguez; Donogh P. O'Brien; Frances Rotblat; Herman Oppermann; Rodney Keck; William I. Wood; Richard N. Harkins; Edward G. D. Tuddenham; Richard M. Lawn; Daniel J. Capon

1984-01-01

191

Neighborhood Risk Factors for Obesity  

Microsoft Academic Search

Objective: The goal of this study was to explore neighborhood environmental factors associated with obesity in a sample of adults living in a major U.S. metropolitan area.Research Methods and Procedures: This was a multi-level study combining data from the U.S. Behavioral Risk Factor Surveillance System with data from the U.S. Census. A total of 15,358 subjects living in 327 zip

Russ P. Lopez

2007-01-01

192

Interstitial fibrosis and growth factors.  

PubMed Central

Interstitial pulmonary fibrosis (IPF) is scarring of the lung caused by a variety of inhaled agents including mineral particles, organic dusts, and oxidant gases. The disease afflicts millions of individuals worldwide, and there are no effective therapeutic approaches. A major reason for this lack of useful treatments is that few of the molecular mechanisms of disease have been defined sufficiently to design appropriate targets for therapy. Our laboratory has focused on the molecular mechanisms through which three selected peptide growth factors could play a role in the development of IPF. Hundreds of growth factors and cytokines could be involved in the complex disease process. We are studying platelet-derived growth factor because it is the most potent mesenchymal cell mitogen yet described, transforming growth factor beta because it is a powerful inducer of extracellular matrix (scar tissue) components by mesenchymal cells, and tumor necrosis factor alpha because it is a pleiotropic cytokine that we and others have shown is essential for the development of IPF in animal models. This review describes some of the evidence from studies in humans, in animal models, and in vitro, that supports the growth factor hypothesis. The use of modern molecular and transgenic technologies could elucidate those targets that will allow effective therapeutic approaches. Images Figure 1 Figure 2 PMID:10931794

Lasky, J A; Brody, A R

2000-01-01

193

Structure-function relationships in factor IX and factor IXa.  

PubMed

Factor IX (FIX) consists of an N-terminal gamma-carboxyglutamic acid (Gla) domain followed by two epidermal growth factor (EGF)-like domains, and the C-terminal serine protease domain. During physiologic coagulation, one of the activators of FIX is the FVIIa/tissue factor (TF) complex. In this reaction, the Gla and EGF1 domains of FIX are thought to interact with TF. The FIXa that is generated then combines with FVIIIa on the platelet surface to activate FX in the coagulation cascade. In this assembly, the protease domain and possibly the EGF2 domain of FIXa are thought to provide the primary specificity in binding to FVIIIa. Disruption of the interaction of FIX/FX with TF and of the FIXa:FVIIIa interface may provide a pharmacologic target as an alternative strategy for the development of antithrombotic agents. PMID:12554099

Schmidt, Amy E; Bajaj, S Paul

2003-01-01

194

Hepatocyte growth factor/scatter factor-induced intracellular signalling  

PubMed Central

Hepatocyte growth factor (HGF) identical to scatter factor (SF) is a glycoprotein involved in the development of a number of cellular phenotypes, including proliferation, mitogenesis, formation of branching tubules and, in the case of tumour cells, invasion and metastasis. This fascinating cytokine transduces its activities via its receptor encoded by the c-met oncogene, coupled to a number of transducers integrating the HGF/SF signal to the cytosol and the nucleus. The downstream transducers coupled to HGF/MET, most of which participate in overlapping pathways, determine the development of the cell's phenotype, which in most cell types is dual. PMID:10718861

Stuart, Katherine A; Riordan, Stephen M; Lidder, Sukhwinderjit; Crostella, Luca; Williams, Roger; Skouteris, George G

2000-01-01

195

Factors influencing healthcare service quality  

PubMed Central

Background: The main purpose of this study was to identify factors that influence healthcare quality in the Iranian context. Methods: Exploratory in-depth individual and focus group interviews were conducted with 222 healthcare stakeholders including healthcare providers, managers, policy-makers, and payers to identify factors affecting the quality of healthcare services provided in Iranian healthcare organisations. Results: Quality in healthcare is a production of cooperation between the patient and the healthcare provider in a supportive environment. Personal factors of the provider and the patient, and factors pertaining to the healthcare organisation, healthcare system, and the broader environment affect healthcare service quality. Healthcare quality can be improved by supportive visionary leadership, proper planning, education and training, availability of resources, effective management of resources, employees and processes, and collaboration and cooperation among providers. Conclusion: This article contributes to healthcare theory and practice by developing a conceptual framework that provides policy-makers and managers a practical understanding of factors that affect healthcare service quality. PMID:25114946

Mosadeghrad, Ali Mohammad

2014-01-01

196

TRASYS form factor matrix normalization  

NASA Technical Reports Server (NTRS)

A method has been developed for adjusting a TRASYS enclosure form factor matrix to unity. This approach is not limited to closed geometries, and in fact, it is primarily intended for use with open geometries. The purpose of this approach is to prevent optimistic form factors to space. In this method, nodal form factor sums are calculated within 0.05 of unity using TRASYS, although deviations as large as 0.10 may be acceptable, and then, a process is employed to distribute the difference amongst the nodes. A specific example has been analyzed with this method, and a comparison was performed with a standard approach for calculating radiation conductors. In this comparison, hot and cold case temperatures were determined. Exterior nodes exhibited temperature differences as large as 7 C and 3 C for the hot and cold cases, respectively when compared with the standard approach, while interior nodes demonstrated temperature differences from 0 C to 5 C. These results indicate that temperature predictions can be artificially biased if the form factor computation error is lumped into the individual form factors to space.

Tsuyuki, Glenn T.

1992-01-01

197

Erikson Psychosocial Stage Inventory: A Factor Analysis  

Microsoft Academic Search

The 72-item Erikson Psychosocial Inventory (EPSI) was factor analyzed for a group of 534 university freshmen and sophomore students. Seven factors including 54 items emerged which the authors labeled Initiative, Industry, Identity, Friendship, Dating, Goal Clarity and Self-Confidence. Items representing Erikson's first two factors, Trust and Autonomy, were dispersed across the new set of factors; this factor pattern was discussed

Mary McPhail Gray; Jean M. Ispa; Kathy R. Thornburg

1986-01-01

198

Von Willebrand factor and aging.  

PubMed

von Willebrand factor (VWF) plays critical roles in initiating primary hemostasis and extending the half-life of coagulation factor VIII in circulation. VWF levels increase with age and elevated levels are associated with an increased risk of venous thromboembolism and cardiovascular disease (CVD). Patients with von Willebrand disease (VWD) due to a deficiency or dysfunction of VWF may have symptoms that ameliorate with aging or may have exacerbation of their disease. Bleeding sites of particular challenge in the aging patient include gastrointestinal bleeding and hematuria. Some medications used to treat VWD should be used with special precaution in older patients, including desmopressin and VWF-containing factor concentrates. Patients with VWD may have some protection from CVD, but in those patients who develop CVD, management is very challenging, given the role of antiplatelet therapy as the mainstay of treatment. PMID:25151524

Konkle, Barbara A

2014-09-01

199

Impact beyond the impact factor.  

PubMed

The journal impact factor is an annually calculated number for each scientific journal, based on the average number of times its articles published in the two preceding years have been cited. It was originally devised as a tool for librarians and publishers to provide information about the citation performance of a journal as a whole, but over the last few decades it has increasingly been used to assess the quality of specific articles and the research performance of individual investigators, institutions, and countries. In addition to this clear abuse of the journal impact factor, several conceptual and technical issues limit its usability as a measure of journal reputation, especially when journals are compared across different fields. An author's decision regarding the suitability of a scholarly journal for publication should, therefore, be based on the impact that this journal makes in the field of research, rather than on the journal impact factor. PMID:24264238

Zupanc, Günther K H

2014-02-01

200

Environmental risk factors for osteoporosis  

SciTech Connect

Environmental risk factors for osteoporosis were reviewed at a conference held at the National Institute for Environmental Health Sciences 8-9 November 1993. The conference was co-sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Disease and the NIH Office of Research in Women's Health. The objective of the conference was to review what is known about risk factors for osteoporosis and to identify gaps in the present state of knowledge that might be addressed by future research. The conference was divided into two broad themes. The first session focused on current knowledge regarding etiology, risk factors, and approaches to clinical and laboratory diagnosis. This was followed by three sessions in which various environmental pollutants were discussed. Topics selected for review included environmental agents that interfere with bone and calcium metabolism, such as the toxic metals lead, cadmium, aluminum, and fluoride, natural and antiestrogens, calcium, and vitamin D.

Goyer, R.A.; Korach, K.S. (National Institute of Environmental Health Sciences, Triangle Park, NC (United States)); Epstein, S. (Albert Einstein Medical Center, Philadelphia, PA (United States)); Bhattacharyya, M. (Argonne National Lab., IL (United States)); Pounds, J. (Wayne State Univ., Detroit, MI (United States))

1994-04-01

201

Isospectral potentials from modified factorization  

SciTech Connect

Factorization of quantum-mechanical potentials has a long history extending back to the earliest days of the subject. In the present article, the nonuniqueness of the factorization is exploited to derive new isospectral nonsingular potentials. Many one-parameter families of potentials can be generated from known potentials using a factorization that involves superpotentials defined in terms of excited states of a potential. For these cases an operator representation is available. If ladder operators are known for the original potential, then a straightforward procedure exists for defining such operators for its isospectral partners. The generality of the method is illustrated with a number of examples which may have many possible applications in atomic and molecular physics.

Berger, Micheal S.; Ussembayev, Nail S. [Department of Physics, Indiana University, Bloomington, Indiana 47405 (United States)

2010-08-15

202

Environmental risk factors for psychosis  

PubMed Central

Genetic factors are clearly important in the etiology of schizophrenia, but the environment in which an individual's genes find expression is also crucial to the development of the illness. In this review of environmental risk factors for schizophrenia, we consider risks operating prenatally and perinatally, during childhood, and then later in life prior to illness onset. Some of these risk factors have been well documented, for example, early hazards causing fetal growth retardation or hypoxia, and hazards nearer the onset of illness like drug abuse and migration. Others are much less certain. The importance of interaction between genetic and environmental risk is, however, undoubtedly important and there is emerging evidence for this from a range of sources. As the etiology of schiz-ophrenia is unraveled, the picture becomes more complex, but also more obviously relevant to the plight of the individual patient. PMID:16060597

Dean, Kimberlie; Murray, Robin M.

2005-01-01

203

Establishing Factor Validity Using Variable Reduction in Confirmatory Factor Analysis.  

ERIC Educational Resources Information Center

Using a 21-statement attitude-type instrument, an iterative procedure for improving confirmatory model fit is demonstrated within the context of the EQS program of P. M. Bentler and maximum likelihood factor analysis. Each iteration systematically eliminates the poorest fitting statement as identified by a variable fit index. (SLD)

Hofmann, Rich

1995-01-01

204

Making a tooth: growth factors, transcription factors, and stem cells  

Microsoft Academic Search

Mammalian tooth development is largely dependent on sequential and reciprocal epithelial-mesenchymal interactions. These processes involve a series of inductive and permissive interactions that result in the determination, differentiation, and organization of odontogenic tissues. Multiple signaling molecules, including BMPs, FGFs, Shh, and Wnt proteins, have been implicated in mediating these tissue interactions. Transcription factors participate in epithelial-mesenchymal interactions via linking the

Yan Ding ZHANG; Zhi CHEN; Yi Qiang SONG; Chao LIU; Yi Ping CHEN

2005-01-01

205

Derived Basic Ability Factors: A Factor Analysis Replication Study.  

ERIC Educational Resources Information Center

The purpose of this study was to replicate the study conducted by Potter, Sagraves, and McDonald to determine whether their recommended analysis could separate criterion variables into similar factors that were stable from year to year and from school to school. The replication samples consisted of all students attending Louisiana State University…

Lee, Mickey, M.; Lee, Lynda Newby

206

Environmental factors associated with asthma.  

PubMed Central

Asthma, a disease of attacks and remission, continues to account for substantial morbidity and direct economic costs. Numerous studies--epidemiologic, toxicologic and clinical--present evidence for a broad spectrum of environmental risk factors associated with asthma. This review summarizes current thinking on a subset of these factors. Knowledge of potential environmental determinants of asthma is important to both the patient and healthcare professional in the application of multiple modalities of medical and environmental intervention for management of the development, and exacerbation of this chronic inflammatory disorder of the airways. PMID:12760611

Walker, Bailus; Stokes, Lynette D.; Warren, Rueben

2003-01-01

207

Growth factors in orthopedic surgery  

PubMed Central

Growth factors have represented an essential issue of interest for the researchers and clinicians in orthopedics and trauma over the last 40 years. In the last 10 to 15 years, the advances registered in this field have permitted the identification of the most active cellular and humoral factors as well as the improvement of their use in the orthopedic and trauma surgery. Their domain of application has been continuously enlarged and the results have been visible from the beginning. The authors present their appreciation on the actual state of this subject as well as their experience with results and related conclusions. PMID:20302195

Zaharia, C; Despa, N; Simionescu, M; Jinga, V; Fleseriu, I

2010-01-01

208

Bayes factors and multimodel inference  

USGS Publications Warehouse

Multimodel inference has two main themes: model selection, and model averaging. Model averaging is a means of making inference conditional on a model set, rather than on a selected model, allowing formal recognition of the uncertainty associated with model choice. The Bayesian paradigm provides a natural framework for model averaging, and provides a context for evaluation of the commonly used AIC weights. We review Bayesian multimodel inference, noting the importance of Bayes factors. Noting the sensitivity of Bayes factors to the choice of priors on parameters, we define and propose nonpreferential priors as offering a reasonable standard for objective multimodel inference.

Link, W.A.; Barker, R.J.

2009-01-01

209

Six and Seven as Factors  

NSDL National Science Digital Library

This 2-lesson unit offers a variety of activities and games to help students master multiplication facts with 6 and 7 as factors. It is intended for students who understand the process of multiplication and have mastered the facts where 0, 1, 2, 3, 4, and 5 are factors. Students make use of the effects and properties of multiplication, write and solve story problems, and develop materials and strategies to assist in becoming fluent with the facts. The unit includes questions for students and teachers, a printable multiplication chart, extension ideas, and link to a Virtual Spinner and an online Times Table applet (both catalogued separately).

Grace M. Burton

2012-01-01

210

Lymphangiogenic factors, mechanisms, and applications  

PubMed Central

Lymphangiogenesis, the growth of lymphatic vessels, is essential in embryonic development. In adults, it is involved in many pathological processes such as lymphedema, inflammatory diseases, and tumor metastasis. Advances during the past decade have dramatically increased the knowledge of the mechanisms of lymphangiogenesis, including the roles of transcription factors, lymphangiogenic growth factors and their receptors, and intercellular and intracellular signaling cascades. Strategies based on these mechanisms are being tested in the treatment of various human diseases such as cancer, lymphedema, and tissue allograft rejection. This Review summarizes the recent progress on lymphangiogenic mechanisms and their applications in disease treatment. PMID:24590272

Zheng, Wei; Aspelund, Aleksanteri; Alitalo, Kari

2014-01-01

211

The Interaction between Factor H and Von Willebrand Factor  

PubMed Central

Complement factor H (fH) is a plasma protein that regulates activation of the alternative pathway, and mutations in fH are associated with a rare form of thrombotic microangiopathy (TMA), known as atypical hemolytic uremic syndrome (aHUS). A more common TMA is thrombotic thrombocytopenic purpura, which is caused by the lack of normal ADAMTS-13-mediated cleavage of von Willebrand factor (VWF). We investigated whether fH interacts with VWF and affects cleavage of VWF. We found that factor H binds to VWF in plasma, to plasma-purified VWF, and to recombinant A1 and A2 domains of VWF as detected by co-immunoprecipitation (co-IP) and surface plasmon resonance assays. Factor H enhanced ADAMTS-13-mediated cleavage of recombinant VWF-A2 as determined by quantifying the cleavage products using Western-blotting, enhanced cleavage of a commercially available fragment of VWF-A2 (FRETS-VWF73) as determined by fluorometric assay, and enhanced cleavage of ultralarge (UL) VWF under flow conditions as determined by cleavage of VWF-platelet strings attached to histamine stimulated endothelial cells. Using recombinant full-length and truncated fH molecules, we found that the presence of the C-terminal half of fH molecule is important for binding to VWF-A2 and for enhancing cleavage of the A2 domain by ADAMTS-13. We conclude that factor H binds to VWF and may modulate cleavage of VWF by ADAMTS-13. PMID:23991205

Feng, Shuju; Liang, Xiaowen; Cruz, Miguel A.; Vu, Hangoc; Zhou, Zhou; Pemmaraju, Naresh; Dong, Jing-Fei; Kroll, Michael H.; Afshar-Kharghan, Vahid

2013-01-01

212

Genetics Home Reference: Complement factor I deficiency  

MedlinePLUS

... literature OMIM Genetic disorder catalog Conditions > Complement factor I deficiency On this page: Description Genetic changes Inheritance ... definitions Reviewed September 2010 What is complement factor I deficiency? Complement factor I deficiency is a disorder ...

213

Risk factors for critical illnesspolyneuromyopathy  

Microsoft Academic Search

Although numerous\\u000aclinical, laboratory, and pharmacological\\u000avariables have been reported\\u000aas significant risk factors\\u000afor critical illness polyneuromyopathy\\u000a(CIPM), there is still no\\u000aconsensus on the aetiology of this\\u000acondition.

J. Bednarík; Petr Vondracek; Ladislav Dusek; Eva Moravcova; Ivan Cundrle

2005-01-01

214

Transcription factor-based biosensor  

DOEpatents

The present invention provides for a system comprising a BmoR transcription factor, a .sigma..sup.54-RNA polymerase, and a pBMO promoter operatively linked to a reporter gene, wherein the pBMO promoter is capable of expression of the reporter gene with an activated form of the BmoR and the .sigma..sup.54-RNA polymerase.

2013-10-08

215

Personality Factors and Instructional Methods  

ERIC Educational Resources Information Center

The Children's Personality Questionnaire (CPQ) was administered to 23 academically handicapped children (mean IQ, 79) and 35 academically gifted students (mean IQ, 147). The CPQ measures 14 distinct personality factors; data on these variables were analyzed using a 2 x 2 (academic ability x sex) analysis of variance design. A stepwise discriminant…

Hunt, Dennis; Randhawa, Bikkar S.

216

NASA Space Human Factors Program  

NASA Technical Reports Server (NTRS)

This booklet briefly and succinctly treats 23 topics of particular interest to the NASA Space Human Factors Program. Most articles are by different authors who are mainly NASA Johnson or NASA Ames personnel. Representative topics covered include mental workload and performance in space, light effects on Circadian rhythms, human sleep, human reasoning, microgravity effects and automation and crew performance.

1992-01-01

217

Factors Influencing Students' College Choice.  

ERIC Educational Resources Information Center

Investigated the effects of demographic variables and locus of control on college choice. Additional factors were examined using the College Choice Influence Scale (CCIS). Locus of control, socioeconomic status, and declared major were shown to influence college choice. Implications are discussed for directing recruitment activity. (LLL)

Martin, Nancy K.; Dixon, Paul N.

1991-01-01

218

ÉSTERES DE FTALATOS - FACTOR ORQUIDOTÓXICO  

Microsoft Academic Search

A decline of sperm parameters and an increase in testicular cancer, hypospadias and cryp- torchidism have been registered in the last 50 years. Environmental human exposure to phtha- late esters is one of the suspected factors that cause these changes. The phthalate esters are used in plastics, paints, pesticides, packing materials and medical devices. When administered to male rats, results

Stefan M. WALISZEWSKI; Grzegorz A. SZYMCZYNSKI; Zbigniew SERAFIN; Rosa M. INFANZÓN; José SILICEO

219

Factors Affecting Illegal Hacking Behavior  

Microsoft Academic Search

The damage caused by illegal hacking has become one of the serious problems facing society. Based on general deterrence theory, social bond theory and social learning theory, the paper proposes a model which examines the factors affecting the likelihood an individual will engage in illegal hacking behavior. Data was gathered from a survey of 127 individuals who attended a hacker’s

Randall Young; Lingling Zhang

2005-01-01

220

Factors Influencing College Science Success  

ERIC Educational Resources Information Center

In this paper, the authors report some of the salient findings of a large-scale, four-year national study, conducted at the Harvard-Smithsonian Center for Astrophysics, entitled "Factors Influencing College Science Success" (FICSS), which surveyed college students who enrolled in first-year biology, chemistry, and physics courses throughout the…

Tai, Robert H.; Sadler, Philip M.; Mintzes, Joel J.

2006-01-01

221

QCD factorization at forward rapidities  

Microsoft Academic Search

We analyze particle production in several reactions on nuclear targets at forward rapidities and different energies. The forward kinematic region at high energies allows to access the smallest Bjorken x. Nuclear effects are then usually interpreted as a result of the coherence effects associated with shadowing or the Color Glass Condensate. QCD factorization of soft and hard interactions requires the

J ?epila; J Nemchik; M Šumbera

2011-01-01

222

Synthetic Division and Matrix Factorization  

ERIC Educational Resources Information Center

Synthetic division is viewed as a change of basis for polynomials written under the Newton form. Then, the transition matrices obtained from a sequence of changes of basis are used to factorize the inverse of a bidiagonal matrix or a block bidiagonal matrix.

Barabe, Samuel; Dubeau, Franc

2007-01-01

223

Factors Affecting Willingness to Mentor  

ERIC Educational Resources Information Center

The paper presents a survey among 300 employees in Northern Italy to assess the willingness to mentor and identify the factors that affect it. Men and respondents with previous mentoring experience indicate a higher willingness to be a mentor. Willingness is affected by personal characteristics that are perceived as necessary for a mentor and the…

Ghislieri, Chiara; Gatti, Paola; Quaglino, Gian Piero

2009-01-01

224

[Virulence factors of Candida albicans].  

PubMed

Candida albicans is the most common etiological factor of opportunistic human fungal infections. In this review, we focus on the major virulence factors that mediate the pathogenesis of C. albicans. Among these virulence factors, secreted aspartyl proteases, adherence, pleomorphism are the most important features of C. albicans infections. Ability to exist as different pleomorphic forms is defined as pleomorphism. A number of quorum sensing (QS) molecules have been described which affect morphogenesis process in C. albicans. Furthermore, the morphological transition of C. albicans in response to changing environmental conditions represent a means by which the strain adapts to different biological niches. Furthermore, every morphotype has own virulence profile and each pleomorphic form provide critical functions required for pathogenesis. Candida albicans is a producer of extracellular hydrolytic enzymes. Among them lipases, phospholipases and secreted aspartyl proteinases (Sap) are most significant in virulence. Sap proteins contribute to pathogenesis by digestion of host cell membranes and molecules of the host immune system to avoid antimicrobial attack by the host. One of the key features in the development of candidiasis is adhesion ofC. albicans to buccal and vaginal epithelial cells. The adhesion to host cells represents the first step in the internalization process which involves adhesins. Knowledge of the role of the various C. albicans' virulence factors during in vivo infections is still incomplete, therefore further studies including quantification of genes expression and histopathological examination of tissues damage are required to fully understand pathogenesis of this opportunistic pathogen. PMID:23484392

Staniszewska, Monika; Bondaryk, Ma?gorzata; Pi?at, Joanna; Siennicka, Katarzyna; Magda, Urszula; Kurzatkowski, Wies?aw

2012-01-01

225

Heredity Factors in Spatial Visualization.  

ERIC Educational Resources Information Center

Spatial visualization is not yet clearly understood. Some researchers have concluded that two factors or abilities are involved, spatial orientation and spatial visualization. Different definitions and different tests have been proposed for these two abilities. Several studies indicate that women generally perform more poorly on spatial tests than…

Vandenberg, S. G.

226

Soft Factors Influence College Enrollment  

ERIC Educational Resources Information Center

Evidence about the role that "soft factors" like student engagement and school environment play in influencing whether high school students go on to enroll in college is hard to come by. Over the past two years, the Center for Labor Market Studies (CLMS) of Northeastern University, with support from the Nellie Mae Education Foundation and the…

Fogg, Neeta P.; Harrington, Paul E.

2010-01-01

227

Pollution, Factor Taxation and Unemployment  

Microsoft Academic Search

When consumers choose between clean and dirty goods and the labour market clears, a green tax reform may not bring about a double dividend in the sense of increasing environmental quality and increasing employment. However, when firms choose between clean and dirty factors of production, and when there is unemployment, such a result is very likely to occur. The paper

Erkki Koskela; Ronnie Schöb; Hans-Werner Sinn

1998-01-01

228

Factors Underlying Cognitive Strategy Use.  

ERIC Educational Resources Information Center

The relationships among the use of self-regulated learning strategies and two important cognitive motivational factors, expectancy of success and task value, were studied using hierarchical regression analysis. Since there are differences in self-regulated strategy use according to level of test anxiety, test anxiety was used as a control…

VanZile-Tamsen, Carol M.

229

Quantum Computers, Factoring and Decoherence  

Microsoft Academic Search

In a quantum computer any superposition of inputs evolves unitarily into the correspond- ing superposition of outputs. It has been recently demonstrated that such computers can dramatically speed up the task of finding factors of large numbers - a problem of great practical significance because of its cryptographic applications. Instead of the nearly ex- ponential (? exp L1\\/3, for a

I. L. Chuang; R. Laflamme; P. Shor; W. H. Zurek

1995-01-01

230

Human factors in software development  

SciTech Connect

This book presents an overview of ergonomics/human factors in software development, recent research, and classic papers. Articles are drawn from the following areas of psychological research on programming: cognitive ergonomics, cognitive psychology, and psycholinguistics. Topics examined include: theoretical models of how programmers solve technical problems, the characteristics of programming languages, specification formats in behavioral research and psychological aspects of fault diagnosis.

Curtis, B.

1986-01-01

231

2012 Critical Success Factors Report  

ERIC Educational Resources Information Center

The Critical Success Factors Report is the North Carolina Community College System's major accountability document. This annual performance report is based on data compiled from the previous year and serves to inform colleges and the public on the performance of North Carolina's 58 community colleges. In 1993, the State Board of Community Colleges…

North Carolina Community College System (NJ1), 2012

2012-01-01

232

2011 Critical Success Factors Report  

ERIC Educational Resources Information Center

The Critical Success Factors Report is the North Carolina Community College System's major accountability document. This annual performance report serves to inform colleges and the public on the performance of North Carolina's 58 community colleges. In 1993, the State Board of Community Colleges began monitoring performance data on specific…

North Carolina Community College System (NJ1), 2011

2011-01-01

233

Solving Quadratic Equations by Factoring  

NSDL National Science Digital Library

This video explains how to solve quadratic equations with the factoring method. In 4 minutes 23 seconds, the two narrators explain in detail the steps required. Additionally, how these equations relate to objects and events in the real world such as roller coasters is covered.

2012-08-06

234

New Photon Exposure Buildup Factors  

Microsoft Academic Search

A New Monte Carlo code (EBUF) is developed to calculate improved point isotropic photon exposure buildup factors in media. Variance reduction techniques are used to perform calculations up to 60 mean free paths. EBUF accounts for coherent scattering and bound-electron Compton scattering. Bremsstrahlung photons and annihilation gamma rays as well as K and L X-rays are considered. The most recent

Chibani; Omar

2001-01-01

235

Time dependent view factor methods  

SciTech Connect

View factors have been used for treating radiation transport between opaque surfaces bounding a transparent medium for several decades. However, in recent years they have been applied to problems involving intense bursts of radiation in enclosed volumes such as in the laser fusion hohlraums. In these problems, several aspects require treatment of time dependence.

Kirkpatrick, R.C.

1998-03-01

236

Form Factors and Vector Mesons  

Microsoft Academic Search

The 2pi and 3pi resonances are re-examined from the point of view that they are vector mesons coupled to conserved currents. The theory of unstable mesons is discussed and formulas are then derived for the emission and propagation of these mesons. The connection with electromagnetic form factors is then given, particularly for the simple case of infinite bare mass. The

Murray Gell-Mann; Fredrik Zachariasen

1961-01-01

237

Human factors in underwater systems.  

PubMed

Applications of human factors to undersea engineering and the relationship to aerospace science are explored. Cooperative ventures include the TEKTITE underwater habitat and development of better procedures to prevent decompression sickness. Other research involved the use of alternate gases in diving systems, remote-operation vehicles, and diving system tests. PMID:11541030

Crosson, D

1993-10-01

238

HUMAN PROSTATE CANCER RISK FACTORS  

EPA Science Inventory

Prostate cancer has the highest prevalence of any non-skin cancer in the human body, with similar likelihood of neoplastic foci found within the prostates of men around the world regardless of diet, occupation, lifestyle, or other factors. Essentially all men with circulating an...

239

Highly parallel sparse Cholesky factorization  

NASA Technical Reports Server (NTRS)

Several fine grained parallel algorithms were developed and compared to compute the Cholesky factorization of a sparse matrix. The experimental implementations are on the Connection Machine, a distributed memory SIMD machine whose programming model conceptually supplies one processor per data element. In contrast to special purpose algorithms in which the matrix structure conforms to the connection structure of the machine, the focus is on matrices with arbitrary sparsity structure. The most promising algorithm is one whose inner loop performs several dense factorizations simultaneously on a 2-D grid of processors. Virtually any massively parallel dense factorization algorithm can be used as the key subroutine. The sparse code attains execution rates comparable to those of the dense subroutine. Although at present architectural limitations prevent the dense factorization from realizing its potential efficiency, it is concluded that a regular data parallel architecture can be used efficiently to solve arbitrarily structured sparse problems. A performance model is also presented and it is used to analyze the algorithms.

Gilbert, John R.; Schreiber, Robert

1990-01-01

240

Factor analysis and scale revision  

Microsoft Academic Search

This article reviews methodological issues that arise in the application of exploratory factor analysis (EFA) to scale revision and refinement. The authors begin by discussing how the appropriate use of EFA in scale revision is influenced by both the hierarchical nature of psychological constructs and the motivations underlying the revision. Then they specifically address (a) important issues that arise prior

Steven P. Reise; Niels G. Waller; Andrew L. Comrey

2000-01-01

241

Factor Analysis and Scale Revision  

Microsoft Academic Search

This article reviews methodological issues that arise in the application of exploratory factor analysis (EFA) to scale revision and refinement. The authors begin by discussing how the appropriate use of EFA in scale revision is influenced by both the hierarchical nature of psychological constructs and the motivations underlying the revision. Then they specifically address (a) important issues that arise prior

Steven P. Reise; Niels G. Waller; Andrew L. Comrey

2000-01-01

242

Stress Factors among College Educators.  

ERIC Educational Resources Information Center

Stress factors affecting community college educators in Ontario were determined using a questionnaire survey. The effect of demographic variables (campus location, program types and specialization, gender, age, and years taught at the college) on perceived stress levels were evaluated. Participants rated their present stress levels on a…

Grant, George Farid

243

Angiogenic growth factors and hypertension  

Microsoft Academic Search

Emerging evidence supports a novel view of hypertension as a disease of inadequate or aberrant responses to angiogenic growth factors (AGF). Patients with hypertension have reduced microvascular density, with some evidence supporting a primary role for rarefaction in causing hypertension. Two clinical models have demonstrated a link between inhibition of AGF activity and hypertension. A major side effect of bevacizumab,

David C. Sane; Lauren Anton; K. Bridget Brosnihan

2004-01-01

244

Prognostic Factors in Hodgkin Lymphoma  

PubMed Central

Hodgkin lymphoma (HL) is among the neoplastic diseases that has the best long-term outcome after cytotoxic treatment. Cure rates approach 80–90%; however, 15–20% of patients will be resistant to therapy (primary refractory) or relapse after treatment. Prognostic factors should help to stratify treatment according to the risk profile and identify patients at risk for failure. Significance of prognostic factors partly depends on the efficacy of the treatments administered, since new effective therapies can variably counterbalance the adverse effects of some unfavorable clinical determinants. As a consequence, some prognostic factors thought to be important in the past may become meaningless when modern successful therapies are used. Therefore, the value of prognostic factors has to be updated periodically, and then adapted to new emerging biomarkers. Besides the prognostic role of PET imaging, tissue and circulating biomarkers, as the number of tumor-infiltrating macrophages, cytokine and chemokine levels and profiling of circulating nucleic acids (DNA and microRNAs) have shown promise. PMID:25045461

Cuccaro, Annarosa; Bartolomei, Francesca; Cupelli, Elisa; Galli, Eugenio; Giachelia, Manuela; Hohaus, Stefan

2014-01-01

245

Factors determining desert dune type  

Microsoft Academic Search

While most observers recognize four elemental types of desert dunes (longitudinal, transverse, barchan and star1-3) there is little agreement about which factors determine these types. The angular relationships between the resultant of sand shifting winds and both the crest and principal slipfaces of the elemental types have been discussed qualitatively for many decades. These relationships have been quantified but the

R. J. Wasson; R. Hyde

1983-01-01

246

Life-Style Risk Factors  

Microsoft Academic Search

This article examines the evidence for two propositions: that health and ability to function can often be sustained into advanced old age through interventions that (1) control risk factors among people already old and (2) improve lifelong health behaviors and life-styles starting with people currently still young. Beginning with a general model of age-related changes in health, function, and survival,

Kenneth G. Manton

1989-01-01

247

Three Factors in Language Design  

Microsoft Academic Search

The biolinguistic perspective regards the language faculty as an organ of the body, along with other cognitive systems. Adopting it, we expect to find three factors that interact to determine (I-) languages attained: genetic endowment (the topic of Universal Grammar), experience, and principles that are language- or even organism-independent. Research has naturally focused on I-languages and UG, the problems of

Noam Chomsky

2005-01-01

248

Factors Influencing Household Recycling Behavior  

Microsoft Academic Search

To investigate factors encouraging or deterring recycling, telephone interviews were used to study recycling behavior, attitudes, and knowledge of 221 randomly selected adults in a suburban city that had begun a citywide curbside recycling program within the past year. Approximately 40% reported participation in the curbside recycling program, and nearly 20% more claimed that their household had been recycling in

Stuart Oskamp; Maura J. Harrington; Todd C. Edwards; Deborah L. Sherwood; Shawn M. Okuda; Deborah C. Swanson

1991-01-01

249

Prognostic factors in prostate cancer.  

PubMed

In the nineteenth century the main goal of medicine was predictive: diagnose the disease and achieve a satisfying prognosis of the patient's chances. Today the effort has shifted to cure the disease. Since the twentieth century, the word prognosis has also been used in nonmedical contexts, for example in corporate finance or elections. The most accurate form of prognosis is achieved statistically. Based on different prognostic factors it should be possible to tell patients how they are expected to do after prostate cancer has been diagnosed and how different treatments may change this outcome. A prognosis is a prediction. The word prognosis comes from the Greek word (see text) and means foreknowing. In the nineteenth century this was the main goal of medicine: diagnose the disease and achieve a satisfying prognosis of the patient's chances. Today the effort has shifted towards seeking a cure. Prognostic factors in (prostate) cancer are defined as "variables that can account for some of the heterogeneity associated with the expected course and outcome of a disease". Bailey defined prognosis as "a reasoned forecast concerning the course, pattern, progression, duration, and end of the disease. Prognostic factors are not only essential to understand the natural history and the course of the disease, but also to predict possible different outcomes of different treatments or perhaps no treatment at all. This is extremely important in a disease like prostate cancer where there is clear evidence that a substantial number of cases discovered by prostate-specific antigen (PSA) testing are unlikely ever to become clinically significant, not to mention mortal. Furthermore, prognostic factors are of paramount importance for correct interpretation of clinical trials and for the construction of future trials. Finally, according to WHO national screening committee criteria for implementing a national screening programme, widely accepted prognostic factors must be defined before assessing screening. PMID:17432552

Braeckman, Johan; Michielsen, Dirk

2007-01-01

250

The mechanism underlying activation of factor IX by factor XIa.  

PubMed

Factor XI (fXI) is the zymogen of a plasma protease, factor XIa (fXIa), that contributes to thrombin generation during blood coagulation by proteolytic conversion of factor IX (fIX) to factor IXa? (fIXa?). There is considerable interest in fXIa as a therapeutic target because it contributes to thrombosis, while serving a relatively minor role in hemostasis. FXI/XIa has a distinctly different structure than other plasma coagulation proteases. Specifically, the protein lacks a phospholipid-binding Gla-domain, and is a homodimer. Each subunit of a fXIa dimer contains four apple domains (A1 to A4) and one trypsin-like catalytic domain. The A3 domain contains a binding site (exosite) that largely determines affinity and specificity for the substrate fIX. After binding to fXIa, fIX undergoes a single cleavage to form the intermediate fIX?. FIX? then rebinds to the A3 domain to undergo a second cleavage, generating fIXa?. The catalytic efficiency for the second cleavage is ~7-fold greater than that of the first cleavage, limiting fIX? accumulation. Residues at the N-terminus and C-terminus of the fXIa A3 domain likely form the fIX binding site. The dimeric conformation of fXIa is not required for normal fIX activation in solution. However, monomeric forms of fXI do not reconstitute fXI-deficient mice in arterial thrombosis models, indicating the dimer is required for normal function in vivo. FXI must be a dimer to be activated normal by the protease fXIIa. It is also possible that the dimeric structure is an adaptation that allows fXI/XIa to bind to a surface through one subunit, while binding to its substrate fIX through the other. PMID:24759143

Gailani, David; Geng, Yipeng; Verhamme, Ingrid; Sun, Mao-fu; Bajaj, S Paul; Messer, Amanda; Emsley, Jonas

2014-05-01

251

Food Ingestion Factors of the Korean Exposure Factors Handbook  

PubMed Central

The purpose of this study was to establish food ingestion factors needed to assess exposure to contaminants through food ingestion. The study reclassified the raw data of the Korean National Health and Nutrition Examination Survey in 2001 into 12 subcategories including grain products, meat products, fish and shellfish, and vegetables for international comparability of exposure evaluation. The criteria for food intake calculation were unified according to the characteristics of food groups, and recommended values for food ingestion factors were calculated through moisture correction and recategorization of cooked, processed, and mixed foods for each group. The average intake rate for grain and grain products was 6.25 g/kg-d per capita and the men's intake rate was approximately 8% higher than that of the women. The average intake rate of meat and meat products was 1.62 g/kg-d per capita and the men's intake rate was 30% higher than that of the women, on average. The average intake rate of fish and shellfish was 1.53 g/kg-d per capita, and the age groups of 1 to 2 and 3 to 6 recorded higher capita intake rates than other age groups, 2.62 g/kg-d and 2.25 g/kg-d, respectively. The average intake rate of vegetables was 6.47 g/kg-d per capita, with the age group of 1 to 2 recording the highest per capita intake rate of 9.79 g/kg-d and that of 13 to 19 recording the lowest mean. The study also offers recommended values for food ingestion factors of other food groups by gender, age, and region. The food ingestion exposure factors will need future updates in consideration of ongoing changes in food consumption behavior. PMID:24570803

Jo, Soo-Nam; Kim, Sun-Ja; Myung, Hyung-Nam; Kim, Cho-Il

2014-01-01

252

Factors influencing susceptibility to metals.  

PubMed Central

Although the long-neglected field of human susceptibility to environmental toxicants is currently receiving renewed attention, there is only scant literature on factors influencing susceptibility to heavy metals. Genetic factors may influence the availability of sulfhydryl-containing compounds such as glutathione and metallothionein, which modify the distribution and toxicity of certain metals. Age and gender play a role in modifying uptake and distribution, although the mechanisms are often obscure. Concurrent exposure to divalent cations may enhance or reduce the toxicity of certain metals through competition for receptor-mediated transport or targets. Increasing use of biomarkers of exposure should greatly increase our understanding of the underlying distribution of susceptibility to various environmental agents. PMID:9255566

Gochfeld, M

1997-01-01

253

Factors influencing pacing in triathlon  

PubMed Central

Triathlon is a multisport event consisting of sequential swim, cycle, and run disciplines performed over a variety of distances. This complex and unique sport requires athletes to appropriately distribute their speed or energy expenditure (ie, pacing) within each discipline as well as over the entire event. As with most physical activity, the regulation of pacing in triathlon may be influenced by a multitude of intrinsic and extrinsic factors. The majority of current research focuses mainly on the Olympic distance, whilst much less literature is available on other triathlon distances such as the sprint, half-Ironman, and Ironman distances. Furthermore, little is understood regarding the specific physiological, environmental, and interdisciplinary effects on pacing. Therefore, this article discusses the pacing strategies observed in triathlon across different distances, and elucidates the possible factors influencing pacing within the three specific disciplines of a triathlon. PMID:25258562

Wu, Sam SX; Peiffer, Jeremiah J; Brisswalter, Jeanick; Nosaka, Kazunori; Abbiss, Chris R

2014-01-01

254

Endometriosis, Angiogenesis and Tissue Factor  

PubMed Central

Tissue factor (TF), is a cellular receptor that binds the factor VII/VIIa to initiate the blood coagulation cascade. In addition to its role as the initiator of the hemostatic cascade, TF is known to be involved in angiogenesis via intracellular signaling that utilizes the protease activated receptor-2 (PAR-2). We now review the physiologic expression of TF in the endometrium and its altered expression in multiple cell types derived from eutopic and ectopic endometrium from women with endometriosis compared with normal endometrium. Our findings suggest that TF might be an ideal target for therapeutic intervention in endometriosis. We have employed a novel immunoconjugate molecule known as Icon and were able to eradicate endometrial lesions in a mouse model of endometriosis without affecting fertility. These findings have major implications for potential treatment in humans. PMID:24278684

Krikun, Graciela

2012-01-01

255

Human Factors and Medical Devices  

SciTech Connect

Medical device hardware- and software-driven user interfaces should be designed to minimize the likelihood of use-related errors and their consequences. The role of design-induced errors in medical device incidents is attracting widespread attention. The U.S. Food and Drug Administration (FDA) is fully cognizant that human factors engineering is critical to the design of safe medical devices, and user interface design is receiving substantial attention by the agency. Companies are paying more attention to the impact of device design, including user instructions, upon the performance of those health professionals and lay users who operate medical devices. Concurrently, the FDA is monitoring human factors issues in its site inspections, premarket device approvals, and postmarket incident evaluations. Overall, the outlook for improved designs and safer device operation is bright.

Dick Sawyer

1998-12-31

256

Factoring integers with elliptic curves  

Microsoft Academic Search

Abstract This paper is devoted to the description and analysis of a new algorithm to factor positive integers. It depends on the use of elliptic curves. The new method is obtained from,Pollard's (p — l)-method (Proc. Cambridge,Philos. Soc. 76 (1974), 521-528) by replacing the multiplicative group by the group of points on a random,elliptic curve. It is conjectured,that the algorithm,determines,a

H. W. Lenstra

1987-01-01

257

Risk Factors for Esophageal Candidiasis  

Microsoft Academic Search

The role of gastric acid inhibitors as predisposing factors for Candida esophagitis is unknown. A retrospective case-control study of esophageal candidiasis was conducted in human immunodeficiency\\u000a virus (HIV)-negative patients diagnosed from January 1991 to December 1997. The diagnosis of esophageal candidiasis was always\\u000a made on the basis of endoscopic and histological criteria. Fifty-one patients were diagnosed with esophageal candidiasis,\\u000a 15

A. Chocarro Martínez; F. Galindo Tobal; G. Ruiz-Irastorza; A. González López; F. Alvarez Navia; C. Ochoa Sangrador; M. I. Martín Arribas

2000-01-01

258

Background factors in anorexia nervosa  

Microsoft Academic Search

Fifty-one adolescents with anorexia nervosa and 51 sex-, age- and school-matched comparison cases were psychiatrically and physically examined. Twenty-four of the anorexia cases constituted the total population of anorexia nervosa cases born in 1970. The cases were examined at a mean age of 16 years. The mothers were interviewed in detail concerning hereditary and other family factors, child's early physical

Maria Råstam; Christopher Gillberg

1992-01-01

259

Impact fact-or fiction?  

PubMed

The Journal Impact Factor dominates research assessment in many disciplines and in many countries. While research assessment will always have to rely to some extent on quantitative, standardized metrics, the focus on this single measure has gone so far as to hamper and distort scientific research. The Declaration on Research Assessment (DORA), signed by influential journals, funders, academic institutions and individuals across the natural sciences, aims to raise awareness and to redress the use of non-objective research assessment practices. PMID:23685358

Pulverer, Bernd

2013-06-12

260

Human factors in incident reporting  

NASA Technical Reports Server (NTRS)

The paper proposes a cooperative research effort be undertaken by academic institutions and industry organizations toward the compilation of a human factors data base in conjunction with technical information. Team members in any discipline can benefit and learn from observing positive examples of decision making and performance by crews under stressful or less than optimal circumstances. The opportunity to note trends in interpersonal and interactive behaviors and to categorize them is terms of more or less desirable outcomes should not be missed.

Jones, S. G.

1993-01-01

261

Link Prediction via Matrix Factorization  

Microsoft Academic Search

\\u000a We propose to solve the link prediction problem in graphs using a supervised matrix factorization approach. The model learns\\u000a latent features from the topological structure of a (possibly directed) graph, and is shown to make better predictions than\\u000a popular unsupervised scores. We show how these latent features may be combined with optional explicit features for nodes or\\u000a edges, which yields

Aditya Krishna Menon; Charles Elkan

262

Tumor Necrosis Factor and Cancer  

Microsoft Academic Search

Tumor necrosis factor a (TNF) is a potent, pleiotropic, proinflammatory cytokine that is produced by macrophages, neutrophils,\\u000a fibroblasts, keratinocytes, NK, T-and B-cells and also by tumor cells. TNF binds to either of two receptors, TNF-R1 or TNF-R2,\\u000a expressed on virtually all mammalian cell types. TNF was named because of its ability, when administered in pharmacologic\\u000a doses, to cause necrosis of

Mark Witte; David J. Shealy; Marian T. Nakada; G. Mark Anderson

263

Quality factor measurements at NTF  

SciTech Connect

The dose equivalent rate in the radiation field outside of the polydoor at the Neutron Therapy Facility has been measured, using a Chipmunk, assuming a quality factor (QF) of 5, to be 25 mrem/hr. This kind of dose rate if true introduced occupancy restrictions and NTF is operating under an exemption. Based on the previous CR-39 studies of the neutron field around NTF,and the amount of shielding around the NTF, it was difficult to believe that a significant neutron field exists in this area, and contributes to the measured dose rate. If the field was mostly due to gamma rays the QF setting on the Chipmunk could be reliably set to a value of one. One method of obtaining a qualitative understanding of the relative abundance of neutron and gamma contribution to the absorbed doses, is to measure the quality factor for the field. This was determined using a recombination chamber. The recombination chamber is a gas filled ion chamber that can measure the average quality factor of a radiation field of unknown composition and energy spectrum. To use the recombination chamber in an unknown field, one needs to measured a calibration curve using radiation fields of known quality factor. The individual neutron and gamma components of the radiation field were also determined in these studies by use of an Andersson-Braun counter to measure the dose equivalent rate due to neutrons, and a Cutup ion chamber to measure the gamma dose rate. The neutron dose equivalent rate in this area of NTF has been estimated by Vylet and is consistent with the present measurements.

Vaziri, K.; Krueger, F.; Kroc, T.; Lauten, G.; Lennox, A.; Leveling, T.

1993-12-17

264

Human Factors in Space Exploration  

NASA Technical Reports Server (NTRS)

The exploration of space is one of the most fascinating domains to study from a human factors perspective. Like other complex work domains such as aviation (Pritchett and Kim, 2008), air traffic management (Durso and Manning, 2008), health care (Morrow, North, and Wickens, 2006), homeland security (Cooke and Winner, 2008), and vehicle control (Lee, 2006), space exploration is a large-scale sociotechnical work domain characterized by complexity, dynamism, uncertainty, and risk in real-time operational contexts (Perrow, 1999; Woods et ai, 1994). Nearly the entire gamut of human factors issues - for example, human-automation interaction (Sheridan and Parasuraman, 2006), telerobotics, display and control design (Smith, Bennett, and Stone, 2006), usability, anthropometry (Chaffin, 2008), biomechanics (Marras and Radwin, 2006), safety engineering, emergency operations, maintenance human factors, situation awareness (Tenney and Pew, 2006), crew resource management (Salas et aI., 2006), methods for cognitive work analysis (Bisantz and Roth, 2008) and the like -- are applicable to astronauts, mission control, operational medicine, Space Shuttle manufacturing and assembly operations, and space suit designers as they are in other work domains (e.g., Bloomberg, 2003; Bos et al, 2006; Brooks and Ince, 1992; Casler and Cook, 1999; Jones, 1994; McCurdy et ai, 2006; Neerincx et aI., 2006; Olofinboba and Dorneich, 2005; Patterson, Watts-Perotti and Woods, 1999; Patterson and Woods, 2001; Seagull et ai, 2007; Sierhuis, Clancey and Sims, 2002). The human exploration of space also has unique challenges of particular interest to human factors research and practice. This chapter provides an overview of those issues and reports on sorne of the latest research results as well as the latest challenges still facing the field.

Jones, Patricia M.; Fiedler, Edna

2010-01-01

265

Racetrack fluxgate sensor core demagnetization factor  

Microsoft Academic Search

The demagnetization factor of a fluxgate core plays an important role in the resulting sensor sensitivity and noise. The global (magnetometric) demagnetization factor of fluxgate sensor ring cores was evaluated using finite element modelling. This new method was verified using measured effective demagnetization factors for ring cores and subsequently used in the modelling of the global demagnetization factor of racetrack

J. Kubík; P. Ripka

2008-01-01

266

Significance Testing in Confirmatory Factor Analytic Models.  

ERIC Educational Resources Information Center

Traditionally, confirmatory factor analytic models are tested against a null model of total independence. Using randomly generated factors in a matrix of 46 aptitude tests, this approach is shown to be unlikely to reject even random factors. An alternative null model, based on a single general factor, is suggested. In addition, an index of model…

Khattab, Ali-Maher; Hocevar, Dennis

267

The Fermat factorization method revisited Robert Erra  

E-print Network

The Fermat factorization method revisited Robert Erra Christophe Grenier 30th June 2009 Abstract We consider the well known Fermat factorization method, we call the Fermat factorization equation the equation works. 1 Introduction Fermat, in a letter to Mersenne around 1643, exposed an algorithm to factor odd

268

The factorization of the ninth Fermat number  

Microsoft Academic Search

In this paper we exhibit the full prime factorization of the ninth Fermat number Fg = 2512 + 1 . It is the product of three prime factors that have 7, 49, and 99 decimal digits. We found the two largest prime factors by means of the number field sieve, which is a factoring algorithm that depends on arithmetic in

H. W. Lenstra; M. S. Manasse; J. M. Pollard

1993-01-01

269

Bayesian Estimation of Categorical Dynamic Factor Models  

ERIC Educational Resources Information Center

Dynamic factor models have been used to analyze continuous time series behavioral data. We extend 2 main dynamic factor model variations--the direct autoregressive factor score (DAFS) model and the white noise factor score (WNFS) model--to categorical DAFS and WNFS models in the framework of the underlying variable method and illustrate them with…

Zhang, Zhiyong; Nesselroade, John R.

2007-01-01

270

The “real” success factors on projects  

Microsoft Academic Search

A comprehensive answer to the question of which factors are critical to project success depends on answering three separate questions: “What factors lead to project management success?”, “What factors lead to a successful project?” and “What factors lead to consistently successful projects?” This paper draws on new empirical research from more than 70 large multi-national or national organizations to answer

Terry Cooke-Davies

2002-01-01

271

Tissue Factor Structure and Function  

PubMed Central

Tissue factor (TF) is an integral membrane protein that is essential to life. It is a component of the factor VIIa-TF complex enzyme and plays a primary role in both normal hemostasis and thrombosis. With a vascular injury, TF becomes exposed to blood and binds plasma factor VIIa, and the resulting complex initiates a series of enzymatic reactions leading to clot formation and vascular sealing. Many cells, both healthy, and tumor cells, produce detectable amounts of TF, especially when they are stimulated by various agents. Despite the relative simplicity and small size of TF, there are numerous contradictory reports about the synthesis and presentation of TF on blood cells and circulation in normal blood either on microparticles or as a soluble protein. Another subject of controversy is related to the structure/function of TF. It has been almost commonly accepted that cell-surface-associated TF has low (if any) activity, that is, is “encrypted” and requires specific conditions/reagents to become active, that is, “decrypted.” However there is a lack of agreement related to the mechanism and processes leading to alterations in TF function. In this paper TF structure, presentation, and function, and controversies concerning these features are discussed. PMID:24278763

Butenas, Saulius

2012-01-01

272

Risk factors for endometrial cancer.  

PubMed

Endometrial cancer is the most common malignancy of women in developed countries, and its incidence is rising among pre- and postmenopausal women. In developed and numerous developing countries endometrial cancer, as well as other types of female cancers are an ever-increasing threat that may be explained, among other reasons, by increased life expectancy and changes in lifestyle factors. Endometrial cancer is more common in postmenopausal women than in premenopausal women. Through a review of the literature it was found that the risk of endometrial cancer is positively correlated with older age, early menarche & late menopause, obesity, family history of endometrial cancer (especially among close relatives), radiation exposure, and infertility particularly in the presence of Polycystic Ovarian Syndrome. Long-term use of unopposed oestrogens for hormone replacement therapy also increases the risk of endometrial cancer. Caucasians have a higher incidence of endometrial cancer than African or Asian women. Obese women were found to be at high risk for developing endometrial cancer, while diabetes, hypertension, and geographical and socioeconomic factors are still inconclusive. Finally, smoking is considered as a protective factor against endometrial cancer due to its anti- estrogenic effect. PMID:24313431

Ali, Aus Tariq

2013-11-01

273

Dietary factors affecting polyphenol bioavailability.  

PubMed

While many epidemiological studies have associated the consumption of polyphenols within fruits and vegetables with a decreased risk of developing several chronic diseases, intervention studies have generally not confirmed these beneficial effects. The reasons for this discrepancy are not fully understood but include potential differences in dosing, interaction with the food matrix, and differences in polyphenol bioavailability. In addition to endogenous factors such as microbiota and digestive enzymes, the food matrix can also considerably affect bioaccessibility, uptake, and further metabolism of polyphenols. While dietary fiber (such as hemicellulose), divalent minerals, and viscous and protein-rich meals are likely to cause detrimental effects on polyphenol bioaccessibility, digestible carbohydrates, dietary lipids (especially for hydrophobic polyphenols, e.g., curcumin), and additional antioxidants may enhance polyphenol availability. Following epithelial uptake, polyphenols such as flavonoids may reduce phase II metabolism and excretion, enhancing polyphenol bioavailability. Furthermore, polyphenols may act synergistically due to their influence on efflux transporters such as p-glycoprotein. In order to understand polyphenol bioactivity, increased knowledge of the factors affecting polyphenol bioavailability, including dietary factors, is paramount. PMID:24828476

Bohn, Torsten

2014-07-01

274

Remarks on KERMA Factors in ACE files  

NASA Astrophysics Data System (ADS)

Some neutron KERMA factors in ACE files are negative and extremely large if nuclear data libraries do not keep energy-balance. The status of neutron KERMA factors in the official ACE file of ENDF/B-VII.1 is examined. As a result, it is found out that neutron KERMA factors of nuclei more than 200 in ENDF/B-VII.1 have some problems. Effects of the inadequate KERMA factor are also investigated, which are large for neutron heat while those are small for total (neutron + gamma) heat. Users who use only neutron KERMA factors should check if the factors are adequate or not before they use the factors.

Konno, C.; Ochiai, K.; Takakura, K.; Sato, S.

2014-04-01

275

INVERSIN EXTRANJERA DIRECTA Y SEGURIDAD JURDICA EN BOLIVIA: UN ANLISIS DE LAS REFORMAS ESTRUCTURALES Y SU IMPLICACIN EN LAS INVERSIONES  

E-print Network

a la Segunda Guerra Mundial, el proceso de transnacionalización asume una nueva característica que lo economía mundial adquiere un ritmo sostenido a partir de la segunda posguerra, con dos características serie de reformas llamadas de segunda generación que van desde la descentralización administrativa del

Paris-Sud XI, Université de

276

ltima Actualizacin martes, 14 de enero de 2014 MSTER INTERUNIVERSITARIO EN MATERIALES ESTRUCTURALES PARA LAS NUEVAS TECNOLOGAS  

E-print Network

BIOMATERIALES Y MATERIALES BIOL�GICOS DCMIQ(UC3M) Ciencia de los Materiales e Ing. Metalúrgica Elena Gordo Odériz Si BIOMATERIALES Y MATERIALES BIOL�GICOS DCMIQ(UC3M) Ciencia de los Materiales e Ing. Metalúrgica Elisa Ruiz-Navas Si BIOMATERIALES Y MATERIALES BIOL�GICOS DCIM (URJC) Ciencia de los Materiales e Ing

Rey Juan Carlos, Universidad

277

Factors Affecting Arctic Weather and Climate  

NSDL National Science Digital Library

The factors discussed in this section are building blocks to understanding arctic weather and climate. Each factor plays an important role alone and in interaction with other factors. The "Arctic Energy Budget" ties all the factors together in a description of the Arctic as a climate system. The different factors are given detailed explanations and examples, and include topics like latitude, land/see distributions, solar radiation, air temperature, Air pressure, winds, humidity, clouds, precipitations, and Arctic energy budgets.

2000-01-01

278

Parton distributions, form factors and Compton scattering  

E-print Network

The soft physics approach to form factors and Compton scattering at moderately large momentum transfer is reviewed. It will be argued that in that approach the Compton cross section is given by the Klein-Nishina cross section multiplied by a factor describing the structure of the proton in terms of two new form factors. These form factors as well as the ordinary electromagnetic form factors represent moments of skewed parton distributions.

Peter Kroll

1999-10-11

279

Understanding adverse events: human factors.  

PubMed

(1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole. PMID:10151618

Reason, J

1995-06-01

280

Understanding adverse events: human factors.  

PubMed Central

(1) Human rather than technical failures now represent the greatest threat to complex and potentially hazardous systems. This includes healthcare systems. (2) Managing the human risks will never be 100% effective. Human fallibility can be moderated, but it cannot be eliminated. (3) Different error types have different underlying mechanisms, occur in different parts of the organisation, and require different methods of risk management. The basic distinctions are between: Slips, lapses, trips, and fumbles (execution failures) and mistakes (planning or problem solving failures). Mistakes are divided into rule based mistakes and knowledge based mistakes. Errors (information-handling problems) and violations (motivational problems) Active versus latent failures. Active failures are committed by those in direct contact with the patient, latent failures arise in organisational and managerial spheres and their adverse effects may take a long time to become evident. (4) Safety significant errors occur at all levels of the system, not just at the sharp end. Decisions made in the upper echelons of the organisation create the conditions in the workplace that subsequently promote individual errors and violations. Latent failures are present long before an accident and are hence prime candidates for principled risk management. (5) Measures that involve sanctions and exhortations (that is, moralistic measures directed to those at the sharp end) have only very limited effectiveness, especially so in the case of highly trained professionals. (6) Human factors problems are a product of a chain of causes in which the individual psychological factors (that is, momentary inattention, forgetting, etc) are the last and least manageable links. Attentional "capture" (preoccupation or distraction) is a necessary condition for the commission of slips and lapses. Yet, its occurrence is almost impossible to predict or control effectively. The same is true of the factors associated with forgetting. States of mind contributing to error are thus extremely difficult to manage; they can happen to the best of people at any time. (7) People do not act in isolation. Their behaviour is shaped by circumstances. The same is true for errors and violations. The likelihood of an unsafe act being committed is heavily influenced by the nature of the task and by the local workplace conditions. These, in turn, are the product of "upstream" organisational factors. Great gains in safety can ve achieved through relatively small modifications of equipment and workplaces. (8) Automation and increasing advanced equipment do not cure human factors problems, they merely relocate them. In contrast, training people to work effectively in teams costs little, but has achieved significant enhancements of human performance in aviation. (9) Effective risk management depends critically on a confidential and preferable anonymous incident monitoring system that records the individual, task, situational, and organisational factors associated with incidents and near misses. (10) Effective risk management means the simultaneous and targeted deployment of limited remedial resources at different levels of the system: the individual or team, the task, the situation, and the organisation as a whole. PMID:10151618

Reason, J

1995-01-01

281

Colic anastomotic leakage risk factors  

PubMed Central

Abstract Background: Anastomotic leakage is a dreaded complication of colorectal surgery, as it greatly increases the morbidity, mortality and has been associated with augmented local recurrence and diminished survival. The frequency of this complication is high in emergency colorectal surgery, especially for bowel occlusion, (13% for emergency vs. 4% in elective), due to visceral distension and, therefore, an incongruence in the size of each of the stumps, combined with the lack of mechanical preparation and risk of fecal contamination during operation. Methods: We studied the incidence of anastomotic fistula in the surgery clinic of the “Sf. Pantelimon” Emergency Hospital, between 2006 and 2010, on a lot of 251 patients who underwent different types of colic resection. Apart from the anatomic location of the disease, and the level of anastomosis, we included in our database the following criteria: the patient’s age and gender, type of colic pathology, surgical technique, emergency or elective surgery, comorbidities. Results: An ileocolic anastomosis was performed for 84 patients (33,46 %), for 114 patients (45,41%) a colo-colic anastomosis was carried out, 2 patients (0,79%) had ileorectal anastomosis and 51 patients (20,31%) underwent a colorectal anastomosis. From the comparative analysis of risk factors (the emergency interventions, the anastomosis location, the age and gender of the patient), a significantly increased value of the relative risk of anastomotic fistula was registered for the cases with emergency intervention (x 6,61) and for the colorectal anastomosis following the left hemi colectomies (x 2,23). Discussions: In our study, among the clinical and biological factors analyzed, emergency intervention was the most signi?cant factor associated with anastomotic leakage. Surgery performed in emergency settings, on debilitated patients without adequate preoperative preparation, has an increased risk for anastomotic dehiscence. PMID:24868253

Calin, MD; B?l?l?u, C; Popa, F; Voiculescu, S; Sc?una?u, RV

2013-01-01

282

Modifications of Coronary Risk Factors  

PubMed Central

In addition to the revascularization and glycemic management interventions assigned at random, the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D) design includes the uniform control of major coronary artery disease risk factors, including dyslipidemia, hypertension, smoking, central obesity, and sedentary lifestyle. Target levels for risk factors were adjusted throughout the trial to comply with changes in recommended clinical practice guidelines. At present, the goals are low-density lipoprotein cholesterol <2.59 mmol/L (<100 mg/dL) with an optional goal of <1.81 mmol/L (<70 mg/dL); plasma triglyceride level <1.70 mmol/L (<150 mg/dL); blood pressure level <130 mm Hg systolic and <80 mm Hg diastolic; and smoking cessation treatment for all active smokers. Algorithms were developed for the pharmacologic management of dyslipidemia and hypertension. Dietary prescriptions for the management of glycemia, plasma lipid profiles, and blood pressure levels were adapted from existing clinical practice guidelines. Patients with a body mass index >25 were prescribed moderate caloric restriction; after the trial was under way, a lifestyle weight-management program was instituted. All patients were formally prescribed both endurance and resistance/flexibility exercises, individually adapted to their level of disability and fitness. Pedometers were distributed as a biofeedback strategy. Strategies to achieve the goals for risk factors were designed by BARI 2D working groups (lipid, cardiovascular and hypertension, and nonpharmacologic intervention) and the ongoing implementation of the strategies is monitored by lipid, hypertension, and lifestyle intervention management centers. PMID:16813737

Albu, Jeanine; Gottlieb, Sheldon H.; August, Phyllis; Nesto, Richard W.; Orchard, Trevor J.

2009-01-01

283

Risk Factors for Infective Endocarditis  

Microsoft Academic Search

record abstracts with risk factor data removed. Cases were more likely than controls to suffer from prior severe kidney disease (adjusted OR [95% CI]516.9 [1.5 to 193], P50.02) and diabetes mellitus (adjusted OR [95% CI]52.7 [1.4 to 5.2], P50.004). Cases infected with skin flora had received intravenous fluids more often (adjusted OR [95% CI]56.7 [1.1 to 41], P50.04) and had

Nondental Exposures; Brian L. Strom; Mph Elias Abrutyn; Jesse A. Berlin; Scd Judith L. Kinman; Roy S. Feldman; Dmsc Paul D. Stolley; Mph Matthew E. Levison; Oksana M. Korzeniowski; Donald Kaye

284

Human factors in space telepresence  

NASA Technical Reports Server (NTRS)

The problems of interfacing a human with a teleoperation system, for work in space are discussed. Much of the information presented here is the result of experience gained by the M.I.T. Space Systems Laboratory during the past two years of work on the ARAMIS (Automation, Robotics, and Machine Intelligence Systems) project. Many factors impact the design of the man-machine interface for a teleoperator. The effects of each are described in turn. An annotated bibliography gives the key references that were used. No conclusions are presented as a best design, since much depends on the particular application desired, and the relevant technology is swiftly changing.

Akin, D. L.; Howard, R. D.; Oliveria, J. S.

1983-01-01

285

Factors Affecting the Earth's Weather  

NSDL National Science Digital Library

This Classroom Connectors lesson plan discusses factors affecting the weather on Earth. Students learn about solar radiation, wind circulation, precipitation, and biomes that result from weather patterns. The site provides goals, objectives, an outline, time required, materials, activities, and closure ideas for the lesson. The Classroom Connectors address content with an activity approach while incorporating themes necessary to raise the activity to a higher cognition level. The major motivation is to employ instructional strategies that bring the students physically and mentally into touch with the science they are studying.

286

Weak-shock reflection factors  

SciTech Connect

The purpose of this paper is to compare reflection factors for weak shocks from various surfaces, and to focus attention on some unsolved questions. Three different cases are considered: square-wave planar shock reflection from wedges; square-wave planar shock reflection from cylinders; and spherical blast wave reflection from a planar surface. We restrict ourselves to weak shocks. Shocks with a Mach number of M{sub O} < 1.56 in air or with an overpressure of {Delta}{sub PI} < 25 psi (1.66 bar) under normal ambient conditions are called weak.

Reichenbach, H. [Ernst Mach Inst., Freiburg (Germany); Kuhl, A.L. [Lawrence Livermore National Lab., El Segundo, CA (United States)

1993-09-07

287

Human factors in spacecraft design  

NASA Technical Reports Server (NTRS)

This paper describes some of the salient implications of evolving mission parameters for spacecraft design. Among the requirements for future spacecraft are new, higher standards of living, increased support of human productivity, and greater accommodation of physical and cultural variability. Design issues include volumetric allowances, architecture and layouts, closed life support systems, health maintenance systems, recreational facilities, automation, privacy, and decor. An understanding of behavioral responses to design elements is a precondition for critical design decisions. Human factors research results must be taken into account early in the course of the design process.

Harrison, Albert A.; Connors, Mary M.

1990-01-01

288

Taking the Error Term of the Factor Model into Account: The Factor Score Predictor Interval  

ERIC Educational Resources Information Center

The problem of factor score indeterminacy implies that the factor and the error scores cannot be completely disentangled in the factor model. It is therefore proposed to compute Harman's factor score predictor that contains an additive combination of factor and error variance. This additive combination is discussed in the framework of classical…

Beauducel, Andre

2013-01-01

289

FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX INHIBITS OSTEOCLASTOGENESIS AND CONTROLS CELL SURVIVAL  

E-print Network

1 FACTOR VIII/VON WILLEBRAND FACTOR COMPLEX INHIBITS OSTEOCLASTOGENESIS AND CONTROLS CELL SURVIVAL VIII/von Willebrand Factor (FVIII/vWF) complex, a molecule involved in coagulation, can be physically Willebrand factor (FVIII/vWF complex). The most well known- genetic disease associated with Factor VIII

Paris-Sud XI, Université de

290

TUMOR NECROSIS FACTOR IS A SURVIVAL AND PROLIFERATION FACTOR FOR HUMAN MYELOMA CELLS1  

E-print Network

1 TUMOR NECROSIS FACTOR IS A SURVIVAL AND PROLIFERATION FACTOR FOR HUMAN MYELOMA CELLS1 MICHEL Keywords: multiple myeloma, apoptosis, tumor necrosis factor, interleukin-6. Running title: TNF that tumor necrosis factor (TNF-) is also a survival factor for myeloma cell lines, although less potent

Paris-Sud XI, Université de

291

The factorization of the ninth Fermat number version 19910227 The factorization of the ninth Fermat number  

E-print Network

The factorization of the ninth Fermat number version 19910227 The factorization of the ninth Fermat prime factorization of the ninth Fermat number F9=2 512 +1 is exhibited. It is the product of three was used. The entire factorization was accomplished in four months. Key words: Fermat number, factoring

Manasse, Mark S. - Microsoft Research

292

Environmental factors influencing blackfly populations  

PubMed Central

Much more information is required on the distribution of blackflies in various parts of the world, and in many cases an adequate methodology for obtaining such information still has to be worked out. A detailed methodology for the collection of information about blackflies is given, which was developed for investigations mainly in the Holarctic regions but is basically applicable to other parts of the world. A brief survey of the population dynamics of various species of blackflies in various parts of the Holarctic regions is given, and the main factors influencing the population dynamics are discussed. Interspecific and intraspecific fluctuations in natural blackfly populations are attributed chiefly to abiotic environmental factors rather than to competition. Larval competition in a given microhabitat is mainly individual, though specimens belonging to a given species may have a slightly more favourable position than others. The use of parasites and in particular the replacement of one species by another are promising methods of blackfly control. Predators are not generally likely to prove useful for this purpose. PMID:5300046

Carlsson, G.

1967-01-01

293

Dissecting soft radiation with factorization.  

PubMed

An essential part of high-energy hadronic collisions is the soft hadronic activity that underlies the primary hard interaction. It includes soft radiation from the primary hard partons, secondary multiple parton interactions (MPI), and factorization-violating effects. The invariant mass spectrum of the leading jet in Z+jet and H+jet events is directly sensitive to these effects, and we use a QCD factorization theorem to predict its dependence on the jet radius R, jet p_{T}, jet rapidity, and partonic process for both the perturbative and nonperturbative components of primary soft radiation. We prove that the nonperturbative contributions involve only odd powers of R, and the linear R term is universal for quark and gluon jets. The hadronization model in Pythia8 agrees well with these properties. The perturbative soft initial state radiation (ISR) has a contribution that depends on the jet area in the same way as the underlying event, but this degeneracy is broken by dependence on the jet p_{T}. The size of this soft ISR contribution is proportional to the color state of the initial partons, yielding the same positive contribution for gg?Hg and gq?Zq, but a negative interference contribution for qq[over ¯]?Zg. Hence, measuring these dependencies allows one to separate hadronization, soft ISR, and MPI contributions in the data. PMID:25793802

Stewart, Iain W; Tackmann, Frank J; Waalewijn, Wouter J

2015-03-01

294

QCD factorization at forward rapidities  

NASA Astrophysics Data System (ADS)

We analyze particle production in several reactions on nuclear targets at forward rapidities and different energies. The forward kinematic region at high energies allows to access the smallest Bjorken x. Nuclear effects are then usually interpreted as a result of the coherence effects associated with shadowing or the Color Glass Condensate. QCD factorization of soft and hard interactions requires the nucleus to be an universal filter for different Fock components of the projectile hadron. We demonstrate, however, that this is not the case in the vicinity of the kinematic limit, x ? 1, where sharing of energy between the projectile constituents becomes an issue. The rise of suppression of particle production with x is confirmed by the E772 and E886 data on Drell-Yan and heavy quarkonia. We show that this effect can also be treated alternatively as an effective energy loss proportional to initial energy. This leads to a nuclear suppression at any energy, and predicts Feynman xF scaling of the suppression. We demonstrate how the kinematic limit influences the high-pT particle production at mid-rapidity where the Cronin enhancement at medium-high pT switches to a suppression at larger pT violating thus QCD factorization. Such an expectation seems to be confirmed by RHIC data for pion and direct photon production. We show that this effect as an additional large-pT suppression significantly revises calculations for jet quenching in heavy ion collisons at RHIC.

?epila, J.; Nemchik, J.; Šumbera, M.

2011-09-01

295

Dissecting Soft Radiation with Factorization  

NASA Astrophysics Data System (ADS)

An essential part of high-energy hadronic collisions is the soft hadronic activity that underlies the primary hard interaction. It includes soft radiation from the primary hard partons, secondary multiple parton interactions (MPI), and factorization-violating effects. The invariant mass spectrum of the leading jet in Z +jet and H +jet events is directly sensitive to these effects, and we use a QCD factorization theorem to predict its dependence on the jet radius R , jet pT, jet rapidity, and partonic process for both the perturbative and nonperturbative components of primary soft radiation. We prove that the nonperturbative contributions involve only odd powers of R , and the linear R term is universal for quark and gluon jets. The hadronization model in Pythia8 agrees well with these properties. The perturbative soft initial state radiation (ISR) has a contribution that depends on the jet area in the same way as the underlying event, but this degeneracy is broken by dependence on the jet pT . The size of this soft ISR contribution is proportional to the color state of the initial partons, yielding the same positive contribution for g g ?H g and g q ?Z q , but a negative interference contribution for q q ¯ ?Z g . Hence, measuring these dependencies allows one to separate hadronization, soft ISR, and MPI contributions in the data.

Stewart, Iain W.; Tackmann, Frank J.; Waalewijn, Wouter J.

2015-03-01

296

Specificity factors in cytoplasmic polyadenylation  

PubMed Central

Poly(A) tail elongation after export of an messenger RNA (mRNA) to the cytoplasm is called cytoplasmic polyadenylation. It was first discovered in oocytes and embryos, where it has roles in meiosis and development. In recent years, however, has been implicated in many other processes, including synaptic plasticity and mitosis. This review aims to introduce cytoplasmic polyadenylation with an emphasis on the factors and elements mediating this process for different mRNAs and in different animal species. We will discuss the RNA sequence elements mediating cytoplasmic polyadenylation in the 3? untranslated regions of mRNAs, including the CPE, MBE, TCS, eCPE, and C-CPE. In addition to describing the role of general polyadenylation factors, we discuss the specific RNA binding protein families associated with cytoplasmic polyadenylation elements, including CPEB (CPEB1, CPEB2, CPEB3, and CPEB4), Pumilio (PUM2), Musashi (MSI1, MSI2), zygote arrest (ZAR2), ELAV like proteins (ELAVL1, HuR), poly(C) binding proteins (PCBP2, ?CP2, hnRNP-E2), and Bicaudal C (BICC1). Some emerging themes in cytoplasmic polyadenylation will be highlighted. To facilitate understanding for those working in different organisms and fields, particularly those who are analyzing high throughput data, HUGO gene nomenclature for the human orthologs is used throughout. Where human orthologs have not been clearly identified, reference is made to protein families identified in man. © 2013 John Wiley & Sons, Ltd. PMID:23776146

Charlesworth, Amanda; Meijer, Hedda A; de Moor, Cornelia H

2013-01-01

297

Risk factors for tornado injuries.  

PubMed

Tornadoes in North and South Carolina on 28 March 1984 caused 252 people to be injured seriously enough to require hospitalization and 59 to be killed. To evaluate risk factors, we gathered information on 238 (94%) of those hospitalized and 46 (78%) of those killed. Those hospitalized or deceased had statistically significantly more deep cuts, concussions, unconsciousness and broken bones than those with them at the time of the tornado who were not hospitalized or killed. People living in mobile homes were more likely to be hospitalized or die than people occupying conventional houses. Other risk factors for hospitalization or death included advanced age (60+ years), no physical protection (not having been covered with a blanket or other object), having been struck by broken window glass or other falling objects, home lifted off its foundation, collapsed ceiling or floor, or walls blown away. More awareness of the tornado risk before it strikes and better adherence to tornado protection guidelines could reduce injuries and deaths in the future. PMID:2083989

Eidson, M; Lybarger, J A; Parsons, J E; MacCormack, J N; Freeman, J I

1990-12-01

298

Prognostic factors of postherpetic neuralgia.  

PubMed Central

The investigation was aimed to determine prognostic factors related to postherpetic neuralgia (PHN), and treatment options for preventing PHN. The data showed 34 (17.0%) out of 188 patients with herpes zoster had severe pain after 4 weeks, and 22 (11.7%) after 8 weeks, compared with 109 (58.0%) at presentation. The age (>/=50 yr), surface area involved (>/=9%), and duration of severe pain (>/=4 weeks) might be the main factors that lead to PHN. On the other hand, gender, dermatomal distribution, accompanied systemic conditions, and interval between initial pain and initiation of treatment might not be implicated in PHN. The subjects were orally received antiviral (valacyclovir), tricyclic antidepressant (amitriptyline), and analgesic (ibuprofen) as the standard treatment in the group 1. In addition to the standard medication, lidocaine solution was sub- and/or perilesionally injected in the group 2, while lidocaine plus prilocaine cream was topically applied to the skin lesions in the group 3. The rates of PHN in the 3 treatment groups were not significantly different, suggesting adjuvant anesthetics may not be helpful to reduce the severity of pain. PMID:12378018

Herr, Hwan

2002-01-01

299

Risk factors of ?-hydroxybutyrate overdosing.  

PubMed

The aim of this study was to identify in recreational drug users the factors which increase the risk of overdosing (OD) with ?-hydroxybutyrate (GHB). A purposive sample of 45 experienced GHB users was interviewed, equally divided into three groups (never OD, occasional OD, and repeat OD). The repeat OD group scored highest on many risk factors regarding GHB use, the occasional OD group scored intermediate, and the never OD group scored lowest. Participants, whether or not they had overdosed on GHB, most often perceived GHB use (e.g. using more GHB than usual, using GHB doses too closely together) as the main reason for GHB OD, and many participants who had overdosed on GHB reported that they had taken more GHB than usual at their most recent occasion of GHB OD. No significant differences in co-use of GHB with other substances were found between the three groups. Our findings indicate that using GHB in the company of groups of friends probably reduces, but does not eliminate, the risk of OD. PMID:24080792

Korf, Dirk J; Nabben, Ton; Benschop, Annemieke; Ribbink, Kim; van Amsterdam, Jan G C

2014-01-01

300

Hepatocyte Growth Factor, Keratinocyte Growth Factor, Their Receptors, Fibroblast Growth Factor Receptor2, and the Cells of the Cornea  

Microsoft Academic Search

Purpose. The purpose of this study was to determine whether messenger RNA coding for hepatocyte growth factor (HGF), HGF receptor (MET), keratinocyte growth factor (KGF), KGF receptor, and fibroblast growth factor (FGF) receptor-2 were produced in primary cul- tures of human corneal epithelial, stromal fibroblast, and endothelial cells, as well as ex vivo corneal epithelium, endothelial cells transfected with the

Steven E. Wilson; Joel W. Walker; Eric L. Chwang; Yu-Guang He

301

A protease-like permeability factor in guinea pig skin: immunologic identity with plasma Hageman factor.  

PubMed Central

Vascular permeability enhancement activity of the protease-like permeability factor derived from guinea pig skin and of active guinea pig Hageman factor (beta HFa) were both inhibited by anti-guinea pig Hageman factor rabbit F(ab')2 antibody. The permeability activity of both factors was also absorbed on anti-Hageman factor F(ab')2-Sepharose beads. The latent form of the permeability factor derived from skin extracts produced a single immunoprecipitation line with anti-Hageman factor and gave a reaction of identity with a precipitation band developing between purified Hageman factor and anti-Hageman factor. The latent permeability factor in the fraction corrected the clotting activity of Hageman-factor-deficient human plasma. The clotting activity was also blocked by anti-Hageman factor F(ab')2 antibody. From these results, it was concluded that the skin permeability factor was immunologically and functionally indistinguishable from Hageman factor of plasma. Extracts were obtained from skin of guinea pigs given intravenous injections of 125I-guinea pig Hageman factor immediately before sacrifice to calculate the amount of Hageman factor in the extravascular tissue space of the skin. The pseudoglobulin fractions of the extracts containing a concentration of Hageman factor of approximately 9 microgram of Hageman factor per gram of skin. This was determined both by immunologic means and procoagulant activity. Only 4% of the Hageman factor in the extract was obtained from the intravascular plasma volume of the skin. Images Figure 1 PMID:7044129

Yamamoto, T.; Cochrane, C. G.

1982-01-01

302

SUSCEPTIBILITY FACTORS IN ENVIRONMENTAL HEALTH (GL GINSBERG, SECTION EDITOR) Environmental Health Factors and Sexually Dimorphic  

E-print Network

SUSCEPTIBILITY FACTORS IN ENVIRONMENTAL HEALTH (GL GINSBERG, SECTION EDITOR) Environmental Health Factors and Sexually Dimorphic Differences in Behavioral Disruptions Cheryl S. Rosenfeld & Brian C on two well-defined extrinsic environmental factors that lead to sexually dimorphic behavioral

Trainor, Brian

303

EXPOSURE FACTORS HANDBOOK (EXTERNAL REVIEW DRAFT) 1996  

EPA Science Inventory

This handbook provided a summary of the available statistical data on various factors used in assessing human exposure. Volume I, General Factors, includes an introduction and discussion of uncertainty and provides data for drinking water consumption, soil ingestion, inha...

304

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2014 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2014-07-01

305

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2013 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2013-07-01

306

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2012 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2012-07-01

307

40 CFR 1033.245 - Deterioration factors.  

Code of Federal Regulations, 2011 CFR

...than locomotive-to-locomotive variability. Multiplicative deterioration factors must be specified to one more significant figure than the applicable standard. (c) Deterioration factors for smoke are always additive. (d) If...

2011-07-01

308

5 CFR 841.404 - Demographic factors.  

Code of Federal Regulations, 2010 CFR

... 2 2010-01-01 2010-01-01 false Demographic factors. 841.404 Section 841.404 Administrative...ADMINISTRATION Government Costs § 841.404 Demographic factors. (a) The Office of Personnel Management...

2010-01-01

309

Smoking, Alienation, and Locus of Control Factors  

ERIC Educational Resources Information Center

College students' responses to Rotter's scale were factor analyzed, and smokers' exsmokers', and nonsmokers' factor scores were compared. The findings suggest the usefulness of the concepts of "alienation" and "alienation from one's body" in understanding life-threatening behaviors. (Author)

Schwebel, Andrew I.; Kaemmerer, William F.

1977-01-01

310

About Alzheimer's Disease: Risk Factors and Prevention  

MedlinePLUS

... Project Act (NAPA) About ADEAR About Alzheimer's Disease: Risk Factors and Prevention We can’t control some ... help with Alzheimer's as well. NIA Information on Risk Factors and Prevention Brain Health Resource Preventing Alzheimer’s ...

311

Heart Disease Risk Factors You Can Control  

MedlinePLUS

... your risk Heart Health and Stroke Heart disease risk factors you can control Did you know? In ... Return to top More information on Heart disease risk factors you can control Read more from womenshealth. ...

312

Tourette Syndrome (TS): Risk Factors and Causes  

MedlinePLUS

... to Other Websites Information For... Media Policy Makers Risk Factors and Causes Language: English Español (Spanish) Recommend on ... Compartir Scientists are studying the causes of and risk factors for Tourette Syndrome (TS) in an effort to ...

313

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2011 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2011-04-01

314

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2014 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2014-04-01

315

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2013 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2013-04-01

316

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2010 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2010-04-01

317

23 CFR 650.707 - Rating factor.  

Code of Federal Regulations, 2012 CFR

...FEDERAL HIGHWAY ADMINISTRATION, DEPARTMENT OF TRANSPORTATION ENGINEERING AND TRAFFIC OPERATIONS BRIDGES, STRUCTURES, AND HYDRAULICS Discretionary Bridge Candidate Rating Factor § 650.707 Rating factor. (a) The following formula is to be...

2012-04-01

318

Capacity Factor Risk At Nuclear Power Plants  

E-print Network

We develop a model of the dynamic structure of capacity factor risk. It incorporates the risk that the capacity factor may vary widely from year-to-year, and also the risk that the reactor may be permanently shutdown prior ...

Du, Yangbo

319

42 CFR 414.28 - Conversion factors.  

Code of Federal Regulations, 2010 CFR

... 2010-10-01 false Conversion factors. 414.28 Section 414.28 Public...MEDICAID SERVICES, DEPARTMENT OF HEALTH AND HUMAN SERVICES (CONTINUED) MEDICARE PROGRAM...Practitioners § 414.28 Conversion factors. CMS establishes CFs in...

2010-10-01

320

Cone Penetrometer N Factor Determination Testing Results  

SciTech Connect

This document contains the results of testing activities to determine the empirical 'N Factor' for the cone penetrometer in kaolin clay simulant. The N Factor is used to releate resistance measurements taken with the cone penetrometer to shear strength.

Follett, Jordan R.

2014-03-05

321

Other Possible Heart Disease Risk Factors  

MedlinePLUS

... your risk Heart Health and Stroke Other possible heart disease risk factors Related information Depression fact sheet Stress ... Return to top More information on Other possible heart disease risk factors Read more from womenshealth.gov Heart ...

322

Common risk factors in bank stocks  

E-print Network

This dissertation provides evidence on the risk factors that are priced in bank equities. Alternative empirical models with precedent in the nonfinancial asset pricing literature are tested, including the single-factor Capital Asset Pricing Model...

Viale, Ariel Marcelo

2007-09-17

323

Human Factors in Intelligence, Surveillance, and Reconnaissance  

E-print Network

Human Factors in Intelligence, Surveillance, and Reconnaissance: Gaps for Soldiers and Technology Recommendations Jonathan Z. Bakdash Human Research and Engineering Directorate U.S. Army Research Laboratory gaps, we use approaches from Human Factors (interactions between humans and technical systems

Preece, Alun

324

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2011-01-01

325

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2014-01-01

326

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2012-01-01

327

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Human factors. 460.15 Section 460...DEPARTMENT OF TRANSPORTATION LICENSING HUMAN SPACE FLIGHT REQUIREMENTS Launch and Reentry with Crew § 460.15 Human factors. An operator must take...

2013-01-01

328

Cognitive Factors Affecting Subjective Probability Assessment  

E-print Network

Cognitive Factors Affecting Subjective Probability Assessment Alyson G. Wilson Institute of Statistics & Decision Sciences, Duke University ISDS Discussion Paper #94--02 February 1, 1994 #12; Cognitive Factors Affecting Subjective Probability Assessment Alyson G. Wilson Institute of Statistics and Decision

West, Mike

329

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2013 CFR

...2013-10-01 2013-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2013-10-01

330

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2014 CFR

...2014-10-01 2014-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2014-10-01

331

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2010 CFR

...2010-10-01 2010-10-01 true Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2010-10-01

332

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2012 CFR

...2012-10-01 2012-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2012-10-01

333

48 CFR 2015.304 - Evaluation factors.  

Code of Federal Regulations, 2011 CFR

...2011-10-01 2011-10-01 false Evaluation factors. 2015.304 Section 2015.304 Federal Acquisition Regulations System NUCLEAR...NEGOTIATION Source Selection Processes and Techniques 2015.304 Evaluation factors. The evaluation...

2011-10-01

334

14 CFR 27.621 - Casting factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Casting factors. 27.621 Section 27.621...Construction General § 27.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2012-01-01

335

14 CFR 29.621 - Casting factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Casting factors. 29.621 Section 29.621...Construction General § 29.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2013-01-01

336

14 CFR 29.621 - Casting factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Casting factors. 29.621 Section 29.621...Construction General § 29.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2011-01-01

337

14 CFR 27.621 - Casting factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Casting factors. 27.621 Section 27.621...Construction General § 27.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2013-01-01

338

14 CFR 25.621 - Casting factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Casting factors. 25.621 Section 25.621...Construction General § 25.621 Casting factors. (a) General. ...of this section apply to any structural castings except castings that are pressure...

2012-01-01

339

14 CFR 27.621 - Casting factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Casting factors. 27.621 Section 27.621...Construction General § 27.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2014-01-01

340

14 CFR 27.621 - Casting factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Casting factors. 27.621 Section 27.621...Construction General § 27.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2011-01-01

341

14 CFR 25.621 - Casting factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Casting factors. 25.621 Section 25.621...Construction General § 25.621 Casting factors. (a) General. ...of this section apply to any structural castings except castings that are pressure...

2014-01-01

342

14 CFR 27.621 - Casting factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Casting factors. 27.621 Section 27.621...Construction General § 27.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2010-01-01

343

14 CFR 29.621 - Casting factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Casting factors. 29.621 Section 29.621...Construction General § 29.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2012-01-01

344

14 CFR 29.621 - Casting factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Casting factors. 29.621 Section 29.621...Construction General § 29.621 Casting factors. (a) General. ...d) of this section apply to structural castings except castings that are pressure...

2014-01-01

345

14 CFR 25.621 - Casting factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Casting factors. 25.621 Section 25.621...Construction General § 25.621 Casting factors. (a) General. ...of this section apply to any structural castings except castings that are pressure...

2011-01-01

346

Crohn's Disease and Ulcerative Colitis: Emotional Factors  

MedlinePLUS

... Factors Q & A Go Back Crohn’s Disease and Ulcerative Colitis: Emotional Factors Q & A Email Print + Share The ... of clinical experience. WHAT IS THE CAUSE OF ULCERATIVE COLITIS AND CROHN’S DISEASE? The origin of IBD is ...

347

Localized shrinkage factors and minimax results  

NASA Technical Reports Server (NTRS)

A condition is derived under which a localized shrinkage factor estimator will be minimax. A specific localized shrinkage factor estimator is described. The nonapplicability of the derived condition to some estimators is shown. Several comments concerning these results are made.

Kostal, H.

1983-01-01

348

Influence of von Willebrand factor on the reactivity of human factor VIII inhibitors with factor VIII.  

PubMed

In order to determine the difference in reactivity of factor (F) VIII inhibitors against the FVIII/von Willebrand factor (vWF) complex and against vWF-deficient FVIII, we investigated a panel of 10 antibodies to FVIII from multitransfused individuals with severe haemophilia A and other pathologies. Immunoblotting of purified FVIII and purified thrombin-cleaved FVIII revealed that in all cases inhibitor epitopes could be localized in the heavy chain (A2 subunit) while in four cases they were also present in the light chain. One of the FVIII inhibitors remained unclassified. The effect on FVIII:C of purified IgG from inhibitor plasmas was tested against a high purity FVIII/vWF concentrate and a monoclonally purified FVIII concentrate with only trace contents of vWF, by two different functional assays. Our results suggest that for those inhibitors showing A2 plus light chain (LC) reactivity, the IgG concentration required to inhibit 50% of FVIII activity in vitro is higher for the FVIII/vWF complex than for the vWF-deficient FVIII. We conclude that there might be a protective role of vWF (at least in vitro) against FVIII inhibitors with A2 and LC subunit specificity. PMID:11442641

Gensana, M; Altisent, C; Aznar, J A; Casaña, P; Hernández, F; Jorquera, J I; Magallón, M; Massot, M; Puig, L

2001-07-01

349

Occupational factors and pancreatic cancer.  

PubMed Central

The relation between occupational factors and pancreatic cancer has been studied by two different approaches: a population based case-control study with two series of controls and a retrospective cohort study based on register data. With both approaches, some support was found for an association with occupational exposure to petroleum products. Associations were also indicated with exposure to paint thinner (case-control study) and work in painting and in paint and varnish factories (cohort study), for exposure to detergents, floor cleaning agents, or polish (case-control study) and with floor polishing or window cleaning (cohort study), and for exposure to refuse (case-control study) and work in refuse disposal plants (cohort study). PMID:3790458

Norell, S; Ahlbom, A; Olin, R; Erwald, R; Jacobson, G; Lindberg-Navier, I; Wiechel, K L

1986-01-01

350

Pediatric intensive care quality factors.  

PubMed

Intensive care has been in the forefront of quality investigations. Outcomes researchers have taken advantage of reliable and robust methods to adjust for severity of illness and other case mix variables, and readily identifiable relevant outcomes (survival and death) to investigate quality factors associated with improved risk-adjusted outcomes. Current studies are limited by using databases of convenience, use of historical controls, small sample sizes, and inadequate case-mix adjustment. Only one study has focused on the comparative advantage of pediatric versus adult intensive care units for injured children; it demonstrated substantially improved risk-adjusted mortality rates. The effect of volume on quality of pediatric intensive care has been the subject of multiple evaluations, although each of these studies has serious limitations. Other studies have demonstrated that the experience of the bedside caregiver is important in patient outcomes. PMID:18091207

Pollack, Murray M

2007-12-01

351

Form factors from lattice QCD  

SciTech Connect

Precision computation of hadronic physics with lattice QCD is becoming feasible. The last decade has seen precent-level calculations of many simple properties of mesons, and the last few years have seen calculations of baryon masses, including the nucleon mass, accurate to a few percent. As computational power increases and algorithms advance, the precise calculation of a variety of more demanding hadronic properties will become realistic. With this in mind, I discuss the current lattice QCD calculations of generalized parton distributions with an emphasis on the prospects for well-controlled calculations for these observables as well. I will do this by way of several examples: the pion and nucleon form factors and moments of the nucleon parton and generalized-parton distributions.

Dru Renner

2012-04-01

352

Manned Mars mission crew factors  

NASA Technical Reports Server (NTRS)

Crew factors include a wide range of concerns relating to the human system and its role in a Mars mission. There are two important areas which will play a large part in determining the crew for a Mars mission. The first relates to the goals and priorities determined for such a vast endeavor. The second is the design of the vehicle for the journey. The human system cannot be separated from the other systems in that vehicle. In fact it will be the human system which drives the development of many of the technical breakthroughs necessary to make a Mars mission successful. As much as possible, the engineering systems must adapt to the needs of the human system and its individual components.

Santy, Patricia A.

1986-01-01

353

Radiant-interchange configuration factors  

E-print Network

) SUM & SUM + Aa09DSVM ISUM a OaO DQ 28 IaReSSeR DSVM a DSUM + STG(l e80) + STG(80e I ) SVM ~ SVM + Re09DSVM + STG(80e80) CF (K ) a DaSUMaS A~CONST IF (XKVal ) R9el'7?19 WM IRK (Se 18) H( X ) eA (K) FOSMATISRXeFSaReSXeFSaR) 80 YO 21 W))ITK (Qe...20) H(K)eA(K)eCF(X) P QMMAT (44X e F8 a 8 e SXe FS a 2 e SX e K I 8 e 6 ) 21 CONTINUE WRITE (6?22) XM?PHI 22 FORMAT(iHQ ~ 44X?BHWIDTH ?F5?2?5X ~ SHANGLE F5 F 1) GQ TO (23 ' 29 ' 2'9 ' 24)?KEY FQR KEY- EQUAL I? THE CONFIGURATION FACTOR KQUALS THK...

Reddin, Thomas Edward

1965-01-01

354

Psychological factors affecting equine performance  

PubMed Central

For optimal individual performance within any equestrian discipline horses must be in peak physical condition and have the correct psychological state. This review discusses the psychological factors that affect the performance of the horse and, in turn, identifies areas within the competition horse industry where current behavioral research and established behavioral modification techniques could be applied to further enhance the performance of animals. In particular, the role of affective processes underpinning temperament, mood and emotional reaction in determining discipline-specific performance is discussed. A comparison is then made between the training and the competition environment and the review completes with a discussion on how behavioral modification techniques and general husbandry can be used advantageously from a performance perspective. PMID:23016987

2012-01-01

355

[Psychological factors in duodenal ulcers].  

PubMed

With the aid of a clinical questionnaire and the I-N-R-personality test of Eysenck (as modified by Böttcher), we examined 127 male patients with clinically and radiologically proven ulcer compared to 145 age-matched persons without gastric affections. The features extraversion, neuroticism (emotional lability) and rigidity were determined and the question of an association with symptoms, age at onset of disease as well as occupational and familial factors statistically analyzed. With high significance, duodenal ulcer patients are more often emotionally labile and psychically more rigid. In the event the disease manifests under the age of 30, in ulcer patients introversion too is pronounced with highly significant frequency. Those patients complaining of conflicts with collaborators, lack of sleep, occupational overexertion, noise, draught at work place, present, compared to others without these complaints, a frequently emotional lability with high significance. PMID:7341221

Bauer, B; Bergmann, M

1981-01-01

356

Factors for Bioenergy Market Development  

SciTech Connect

Focusing on the development of the whole bioenergy market rather than isolated projects, this paper contributes to the identification of barriers and drivers behind bioenergy technology implementation. It presents a framework for the assessment of the potentials for bioenergy market growth to be used by decision makers in administration and industry. The conclusions are based on case studies of operating bioenergy markets in Austria, US and Sweden. Six important factors for bioenergy market growth have been identified: (1) Integration with other business, e.g. for biomass procurement, (2) Scale effects of bioenergy market, (3) Competition on bioenergy market, (4) Competition with other business, (5) National policy, (6) Local policy and local opinion. Different applications of the framework are discussed.

Roos, A.; Hektor, B.; Graham, R.L.; Rakos, C.

1998-10-04

357

The pH Factor  

NSDL National Science Digital Library

The Miami Museum of Science's learning site, The pH Factor, gives teachers a fun and interactive way to teach elementary and middle school students some basics of science. Material is divided into seven learning areas: excite, explore, explain, expand, extend, exchange, and examine. Each contains an interactive screen that can be used directly in the classroom and lesson plans that correspond with each subject. For example, the excite area contains the "tasting tongue" that, when clicked, shows the location on the tongue where you taste bitter or sour things. The site's teaching style is based on the proposition that learners need to build their own understanding of new ideas. The unique material that is offered on this site provides educators with an excellent alternative for teaching these sometimes difficult concepts to grade school students.

358

Blood coagulation factor VIII: An overview  

Microsoft Academic Search

Factor VIII (FVIII) functions as a co-factor in the blood coagulation cascade for the proteolytic activation of factor X by\\u000a factor IXa. Deficiency of FVIII causes hemophilia A, the most commonly inherited bleeding disorder. This review highlights\\u000a current knowledge on selected aspects of FVIII in which both the scientist and the clinician should be interested.

G. M. Bhopale; R. K. Nanda

2003-01-01

359

Unity power factor switching regulator  

NASA Technical Reports Server (NTRS)

A single or multiphase boost chopper regulator operating with unity power factor, for use such as to charge a battery is comprised of a power section for converting single or multiphase line energy into recharge energy including a rectifier (10), one inductor (L.sub.1) and one chopper (Q.sub.1) for each chopper phase for presenting a load (battery) with a current output, and duty cycle control means (16) for each chopper to control the average inductor current over each period of the chopper, and a sensing and control section including means (20) for sensing at least one load parameter, means (22) for producing a current command signal as a function of said parameter, means (26) for producing a feedback signal as a function of said current command signal and the average rectifier voltage output over each period of the chopper, means (28) for sensing current through said inductor, means (18) for comparing said feedback signal with said sensed current to produce, in response to a difference, a control signal applied to the duty cycle control means, whereby the average inductor current is proportionate to the average rectifier voltage output over each period of the chopper, and instantaneous line current is thereby maintained proportionate to the instantaneous line voltage, thus achieving a unity power factor. The boost chopper is comprised of a plurality of converters connected in parallel and operated in staggered phase. For optimal harmonic suppression, the duty cycles of the switching converters are evenly spaced, and by negative coupling between pairs 180.degree. out-of-phase, peak currents through the switches can be reduced while reducing the inductor size and mass.

Rippel, Wally E. (Inventor)

1983-01-01

360

Factors Associated With Vulvodynia Incidence  

PubMed Central

Objective To assess incidence rates of and risk factors for vulvodynia. Methods We conducted a longitudinal population-based study of women in southeast Michigan (Woman to Woman Health Study) using a validated survey-based screening test for vulvodynia that was repeated at 6-month intervals over 30 months. Unadjusted incidence rates were determined using Poisson models. Demographic and symptom-related risk factors for incidence were assessed using discrete time survival analysis. Results Women who screened negative for vulvodynia at baseline and were followed through at least one additional survey (n=1786), were assessed for onset of vulvodynia. The incidence rate was 4.2 cases per 100 person-years, and rates per 100 person-years were greater in women who were younger (7.6 cases per 100 person-years at age 20, compared with 3.3 cases per 100 person-years at age 60), Hispanic (9.5), married or living as married (4.9); had reported symptoms of vulvar pain but did not meet vulvodynia criteria on the initial survey (11.5); or had reported past symptoms suggesting a history of vulvodynia (7.5). Increased risk of new onset vulvodynia also included baseline sleep disturbance, chronic pain in general, specific comorbid pain disorders, and specific comorbid psychological disorders. Conclusions The incidence rates of vulvodynia differ by age, ethnicity and marital status. Onset is more likely among women with previous symptoms of vulvodynia or those with intermediate symptoms not meeting criteria for vulvodynia, and among those with preexisting sleep, psychological, and comorbid pain disorders. This suggests vulvodynia is an episodic condition with a potentially identifiable prodromal phase. PMID:24402591

Reed, Barbara D.; Legocki, Laurie J.; Plegue, Melissa A.; Sen, Ananda; Haefner, Hope K.; Harlow, Sioban D.

2014-01-01

361

Measurement Bias Detection through Factor Analysis  

ERIC Educational Resources Information Center

Measurement bias is defined as a violation of measurement invariance, which can be investigated through multigroup factor analysis (MGFA), by testing across-group differences in intercepts (uniform bias) and factor loadings (nonuniform bias). Restricted factor analysis (RFA) can also be used to detect measurement bias. To also enable nonuniform…

Barendse, M. T.; Oort, F. J.; Werner, C. S.; Ligtvoet, R.; Schermelleh-Engel, K.

2012-01-01

362

WIRTSCHAFTS Non-Linear Factor Selection and  

E-print Network

WIRTSCHAFTS INFORMATIK Non-Linear Factor Selection and Copula of Copulas Ulrich Müller-Funk, joint work with Kay Hildebrand Non-Linear Factor Selection and Copula of Copulas Ulrich Müller-Funk #12;Agenda Introduction Approaches Tools 2 Non-Linear Factor Selection and Copula of Copulas Introduction

Hennig, Christian

363

EXPOSURE FACTORS HANDBOOK (1997 FINAL REPORT)  

EPA Science Inventory

The Exposure Factors Handbook provides a summary of the available statistical data on various factors used in assessing human exposure. This Handbook is addressed to exposure assessors inside the Agency as well as outside, who need to obtain data on standard factors to calculate ...

364

Calculational methods for response and weighting factors  

Microsoft Academic Search

Response factors relate the heat flow at the surface of a wall to the history of temperatures at the surfaces of the wall. They have been calculated in the past using Laplace transform. It is shown that fast Fourier transforms provide a simple and efficient way to calculate response factors. Weighting factors relate the cooling of heating load of a

Subbarao

1980-01-01

365

The Infinitesimal Jackknife with Exploratory Factor Analysis  

ERIC Educational Resources Information Center

The infinitesimal jackknife, a nonparametric method for estimating standard errors, has been used to obtain standard error estimates in covariance structure analysis. In this article, we adapt it for obtaining standard errors for rotated factor loadings and factor correlations in exploratory factor analysis with sample correlation matrices. Both…

Zhang, Guangjian; Preacher, Kristopher J.; Jennrich, Robert I.

2012-01-01

366

Factors Affecting Students' Retention at Kuwait University  

ERIC Educational Resources Information Center

This article addresses the factors that affect students' retention at Kuwait University. Five hundred seventy students participated in the study. A survey of 22 retention factors was designed to measure student perceptions. Students presented their agreement on factors which included: achieving personal aspiration, getting jobs, free-of-charge…

AlKandari, Nabila

2008-01-01

367

Factor Analysis of the Interpersonal Trust Scale  

ERIC Educational Resources Information Center

Separate factor analyses of four large samples of respondents to Rotter's Interpersonal Trust Scale produced three orthogonal factors that cross-validated over all samples. Results indicate there may be relatively independent dimensions of trust and factor scores may yield greater prediction than the general scale in many research applications.…

Wright, Thomas L.; Tedeschi, Richard G.

1975-01-01

368

Risk Factors for Chronic Kidney Disease  

MedlinePLUS

Home » Kidney Info » 1 in 9 Adults Risk Factors for CKD When you have a risk factor, it means you are more likely to have a problem than someone who does ... to prevent or delay kidney failure. Kidney Disease Risk Factors You Can Change Diabetes Type 2 diabetes ...

369

Configurations of Common Childhood Psychosocial Risk Factors  

ERIC Educational Resources Information Center

Background: Co-occurrence of psychosocial risk factors is commonplace, but little is known about psychiatrically-predictive configurations of psychosocial risk factors. Methods: Latent class analysis (LCA) was applied to 17 putative psychosocial risk factors in a representative population sample of 920 children ages 9 to 17. The resultant class…

Copeland, William; Shanahan, Lilly; Costello, E. Jane; Angold, Adrian

2009-01-01

370

Short Papers___________________________________________________________________________________________________ Approximate Bayes Factors for Image  

E-print Network

___________________________________________________________________________________________________ Approximate Bayes Factors for Image Segmentation: The Pseudolikelihood Information Criterion (PLIC) Derek C as corresponding to a statistical model for the image, and the resulting models are compared via approximate Bayes factors. The Bayes factors are approximated using BIC (Bayesian Information Criterion), where the required

Raftery, Adrian

371

Erikson Psychosocial Stage Inventory: A Factor Analysis  

ERIC Educational Resources Information Center

The 72-item Erikson Psychosocial Stage Inventory (EPSI) was factor analyzed for a group of 534 university freshmen and sophomore students. Seven factors emerged, which were labeled Initiative, Industry, Identity, Friendship, Dating, Goal Clarity, and Self-Confidence. Item's representing Erikson's factors, Trust and Autonomy, were dispersed across…

Gray, Mary McPhail; And Others

1986-01-01

372

Molecular Complementarity of Yeast Glycoprotein Mating Factors  

Microsoft Academic Search

Cell fusion between opposite mating types 5 and 21 of the yeast Hansenula wingei is initiated by a strong sexual agglutination reaction. The mating factors responsible for the specificity of cellular recognition are complementary glycoproteins which form a physical complex in vitro. The complex is assayed by recovery of agglutination activity of the multivalent 5-factor after the univalent 21-factor has

Marjorie Crandall; Lawrence M. Lawrence; Robert M. Saunders

1974-01-01

373

Herzberg revisited: factors in job dissatisfaction.  

PubMed

A study of nursing personnel in a private general hospital suggests that the high rate of turnover results as much from dissatisfaction with intrinsic job factors as from dissatisfaction with extrinsic factors. These findings contradict the Herzberg two-factor theory, and suggest alternative means of improving management of nurses. PMID:299547

Ullrich, R A

1978-10-01

374

Human factors: a necessary tool for industry  

SciTech Connect

The need for human factors (ergonomics) input in the layout of a ferroelectric ceramics laboratory is presented as an example of the overall need for human factors professionals in industry. However, even in the absence of one trained in human factors, knowledge of a few principles in ergonomics will provide many possibilities for improving performance in the industrial environment.

Starcher, K.O.

1984-03-09

375

Question Number Two: How Many Factors?  

ERIC Educational Resources Information Center

Exploratory factor analysis involves five key decisions. The second decision, how many factors to retain, is the focus of the current paper. Extracting too many or too few factors often leads to devastating effects on study results. The advantages and disadvantages of the most effective and/or most utilized strategies to determine the number of…

Goodwyn, Fara

2012-01-01

376

Lattice Computations of the Pion Form Factor  

SciTech Connect

We report on a program to compute the electromagnetic form factors of mesons. We discuss the techniques used to compute the pion form factor and present results computed with domain wall valence fermions on MILC asqtad lattices, as well as with Wilson fermions on quenched lattices. The methods can easily be extended to rho-to-gamma-pi transition form factors.

Frederic Bonnet; Robert Edwards; George Fleming; Randal Lewis; David Richards

2004-12-01

377

14 CFR 460.15 - Human factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Human factors. 460.15 Section 460.15...Reentry with Crew § 460.15 Human factors. An operator must take the precautions necessary to account for human factors that can affect a crew's...

2010-01-01

378

The Factor Game (i-Math Investigations)  

NSDL National Science Digital Library

An online, interactive, multimedia math investigation. The Factor Game engages students in a friendly contest in which winning strategies involve distinguishing between numbers with many factors and numbers with few factors. Students are then guided through an analysis of game strategies and introduced to the definitions of prime and composite numbers.

Math Forum

2001-01-01

379

A Study of Factors Influencing Superintendent Departure  

ERIC Educational Resources Information Center

Despite a vast amount of national research on superintendent tenure, a paucity of research exists as to the degree in which specific factors influence a superintendent's decision to leave a district. The purpose of the study was to investigate the factors or combination of factors that may influence a superintendent's decision to leave a…

Domene, Doug

2012-01-01

380

Rainbow H-factors Raphael Yuster  

E-print Network

Rainbow H-factors Raphael Yuster Department of Mathematics University of Haifa, Haifa 31905, Israel, a rainbow H-subgraph of G is an H-subgraph of G whose edges have distinct colors. A rainbow H-factor is an H-factor whose components are rainbow H-subgraphs. The follow- ing result is proved. If H is any fixed graph

Yuster, Raphael

381

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

382

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2011-01-01

383

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2010-01-01

384

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2011-01-01

385

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2010-01-01

386

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2012-01-01

387

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

388

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

389

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2012-01-01

390

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2010-01-01

391

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2010 CFR

...2010-01-01 2010-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2010-01-01

392

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2011-01-01

393

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2013 CFR

...2013-01-01 2013-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2013-01-01

394

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2012-01-01

395

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2012 CFR

...2012-01-01 2012-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2012-01-01

396

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2014-01-01

397

14 CFR 23.623 - Bearing factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Bearing factors. 23.623 Section 23.623...Design and Construction § 23.623 Bearing factors. (a) Each part that has...to pounding or vibration, must have a bearing factor large enough to provide for...

2014-01-01

398

14 CFR 25.623 - Bearing factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Bearing factors. 25.623 Section 25.623...Construction General § 25.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2014-01-01

399

14 CFR 29.623 - Bearing factors.  

Code of Federal Regulations, 2014 CFR

...2014-01-01 2014-01-01 false Bearing factors. 29.623 Section 29.623...Construction General § 29.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2014-01-01

400

14 CFR 27.623 - Bearing factors.  

Code of Federal Regulations, 2011 CFR

...2011-01-01 2011-01-01 false Bearing factors. 27.623 Section 27.623...Construction General § 27.623 Bearing factors. (a) Except as provided...to pounding or vibration, must have a bearing factor large enough to provide for...

2011-01-01

401

Human factors in software security risk management  

Microsoft Academic Search

All kinds of human factors can deeply affect the results and efficiency of software risk management. This paper focuses on our ongoing work of studying human factors in security risk management. The human factors are identified and classified for the categories of individual, team, management and stakeholder, as well as for the activities of security risk identification, analysis and mitigation.

Shareeful Islam; Wei Dong

2008-01-01

402

Age Learning Factors Affecting Pilot Education.  

ERIC Educational Resources Information Center

This document, intended for pilot education and flight safety specialists, consists chiefly of a review of the literature on physiological factors that affect pilot education and an examination of environmental factors that should be scrutinized in order to improve the effectiveness of aviation learning facilities. The physiological factors…

Torbert, Brison

403

Factors Affecting Transfer of Training in Thailand  

ERIC Educational Resources Information Center

To begin the validation process for the Learning Transfer System Inventory (LTSI) in Thailand, research replicating Holton, Bates, and Ruona's study (2000) was conducted in Thailand. The LTSI was administered to 1,029 employees. Exploratory factor analysis and MANOVA were used to identify factors. A factor structure almost identical to that of…

Yamnill, Siriporn; McLean, Gary N.

2005-01-01

404

Factorization and scaling in hard diffraction  

SciTech Connect

We compare results on diffractive W-boson production at the Tevatron with predictions based on the diffractive structure function measured in deep inelastic scattering at HERA assuming (a) conventional factorization or (b) hard factorization combined with a rapidity gap distribution scaled to the total gap probability. We find that conventional factorization fails, while the scaling prediction agrees with the data.

Goulianos, Konstantin [Rockefeller University, New York, New York 10021 (United States)

1997-04-20

405

ESTIMATING UNCERTAINITIES IN FACTOR ANALYTIC MODELS  

EPA Science Inventory

When interpreting results from factor analytic models as used in receptor modeling, it is important to quantify the uncertainties in those results. For example, if the presence of a species on one of the factors is necessary to interpret the factor as originating from a certain ...

406

Genetics Home Reference: Factor X deficiency  

MedlinePLUS

... factor X deficiency. Reduced quantity or function of coagulation factor X prevents blood from clotting normally, causing episodes of abnormal bleeding that can be severe. A non-inherited form of the disorder, called acquired factor X deficiency, is more common ...

407

AUTOSOMAL RECESSIVE DEFICIENCIES OF COAGULATION FACTORS  

Microsoft Academic Search

Deficiencies of coagulation factors that cause a bleeding disorder, other than factor VIII and factor IX, are inherited as autosomal recessive traits and are generally rare, with prevalence in the general population varying between 1 in 500 000 and 1 in 2 000 000. In the last few years, the number of patients with recessively transmitted coagulation deficiencies has increased

F. Peyvandi; R. Asselta; P. M. Mannucci

2001-01-01

408

Factor Structure of the Group Engagement Measure  

ERIC Educational Resources Information Center

The Group Engagement Measure (GEM) assesses a commonly used, but rarely measured, process in group work. Earlier studies examined the reliability and validity of the GEM, but none empirically examined its factor structure. The authors examined the seven-factor, 37-item structure of the GEM, using confirmatory factor analysis involving a combined…

Macgowan, Mark J.; Newman, Frederick L.

2005-01-01

409

Growth Factors in Proliferative Diabetic Retinopathy  

PubMed Central

Many growth factors are implicated in the pathogenesis of proliferative diabetic retinopathy. Alteration of growth factors and their receptors in diabetes has been shown in both experimental and clinical studies. Sustained hyperglycemia resulting from long-standing diabetes leads to several biochemical abnormalities that consequently result in retinal hypoxia. Retinal oxygenation state regulates various growth factors that promote angiogenesis in order to meet the oxygen demands of the tissue. However, unregulated expression of these growth factors and induction of complex cascades leading to augmentation of other proangiogenic factors, which may not be regulated by tissue oxygenation, leads to uncontrolled retinal neovascularization and blindness in diabetic patients. PMID:14668050

Khan, Zia Ali

2003-01-01

410

Overexpression of multisubunit replication factors in yeast.  

PubMed

Facile genetic and biochemical manipulation coupled with rapid cell growth and low cost of growth media has established the yeast Saccharomyces cerevisiae as a versatile workhorse. This article describes the use of yeast expression systems for the overproduction of complex multipolypeptide replication factors. The regulated overexpression of these factors in yeast provides for a readily accessible and inexpensive source of these factors in large quantities. The methodology is illustrated with the five-subunit replication factor C. Whole-cell extracts are prepared by blending yeast cells with glass beads or frozen yeast with dry ice. Procedures are described that maximize the yield of these factors while minimizing proteolytic degradation. PMID:10454996

Burgers, P M

1999-07-01

411

Review of critical factors for SEA implementation  

SciTech Connect

The implementation process involved in translating Strategic Environmental Assessment (SEA) intention into action is vital to an effective SEA. Many factors influence implementation and thus the effectiveness of an SEA. Empirical studies have identified and documented some factors influencing the implementation of an SEA. This research is fragmented, however, and it is still not clear what are the most critical factors of effective SEA performance, and how these relate to different stages of the implementation process or other contextual circumstances. The paper takes its point of departure in implementation theory. Firstly, we introduce implementation theory, and then use it in practice to establish a more comprehensive model related to the stages in the implementation process. Secondly, we identify the critical factors in order to see how they are related to the different stages of SEA or are more general in character. Finally we map the different critical factors and how they influence the overall results of an SEA. Based on a literature review, we present a comprehensive picture of the critical factors and where they are found in the process. We conclude that most of the critical factors identified are of a more general character influencing the SEA process as such, while only one out of four of these factors relates to the specific stages of the SEA. Based on this mapping we can sketch a picture of the totality of critical factors. In this study 266 notions of critical factors were identified. Seen at the level of notions of critical factors, only 24% of these relate to specific stages while for 76% the critical factors are of a more general nature. These critical factors interact in complex ways and appear in different combinations in different stages of the implementation process so tracing the cause and effect is difficult. The pervasiveness of contextual and general factors also clearly suggests that there is no single way to put SEA into practice. The paper identifies some of the critical factors for effective SEA implementation, but further research is still needed to conclude which factors are more critical than others, just as the contingencies on which they depend are not easy to unravel. - Highlights: Black-Right-Pointing-Pointer The research on critical factors influencing SEA implementation is fragmented. Black-Right-Pointing-Pointer The critical factors are used to discuss 'hot-spots' in the implementation process. Black-Right-Pointing-Pointer Critical factors are just as broad as the concept of effectiveness. Black-Right-Pointing-Pointer Both stage and general factors are relevant in explaining the effectiveness of SEA.

Zhang Jie, E-mail: jasmine@plan.aau.dk; Christensen, Per; Kornov, Lone

2013-01-15

412

Human Factors Engineering Standards at NASA  

NASA Technical Reports Server (NTRS)

NASA has begun a new approach to human factors design standards. For years NASA-STD-3000, Manned Systems Integration Standards, has been a source of human factors design guidance for space systems. In order to better meet the needs of the system developers, NASA is revising its human factors standards system. NASA-STD-3000 will be replaced by two documents: set of broad human systems design standards (including both human factors and medical topics) and a human factors design handbook. At the present time the standards document is in final review with some disagreement on several critical issues. The handbook is progressing with November 2008 as the anticipated completion date.

Russo, Dane; Tillman, Barry; Pickett, Lynn

2008-01-01

413

Visual impairment and socioeconomic factors  

PubMed Central

BACKGROUND—Information about socio economic factors associated with visual impairment can assist in the design of intervention programmes. Such information was collected by the Melbourne Visual Impairment Project (Melbourne VIP).?METHODS—The Melbourne VIP was a population based study of non-institutionalised permanent residents in nine suburbs of the Melbourne metropolitan area aged 40 years of age and older. A standardised eye examination was provided to eligible residents which included a structured interview. Variables of interest for this analysis were age, sex, country of birth, language spoken at home, education level, use of private health insurance, employment status, and living arrangements. Visual impairment was defined as a best corrected visual acuity <6/18 and/or visual field constriction to within 20° of fixation?RESULTS—A total of 3271 (83%) residents participated. Participants ranged in age from 40 to 98 years; 54% were female. Forty four (1.34%) were classified as visually impaired due to visual acuity and/or visual field loss. To evaluate the independent association of the significant sociodemographic variables with visual impairment, a regression model was constructed that included age, retirement status, use of private health insurance, and household arrangement. The results showed that age was the significant predictor of visual impairment (OR: 3.19; CI: 2.29-4.43), with the mean age of people with visual impairment significantly older (75.0 years) compared with people without visual impairment (58.2 years) (t test=9.71; p=0.0001). Of the 44 visually impaired people, 39 (87%) were aged 60 years of age and older.?CONCLUSION—The results indicate that age is the most significant factor associated with visual impairment. Of some importance was the finding that people with visual impairment were less likely to have private health insurance. With the aging of the population, the number of people affected by visual impairment will increase significantly. Intervention programmes need to be established before the onset of middle age to offset the escalation of visual impairment in the older population.?? PMID:9290372

Livingston, P; McCarty, C; Taylor, H

1997-01-01

414

Factor tree (grades 6-8)  

NSDL National Science Digital Library

This virtual manipulative challenges the learner to find the prime factors for a pair of numbers. The factors for each number are displayed in a tree diagram from which the student drags the factors to the appropriate areas of a Venn diagram. The Venn diagram offers a useful visual display showing unique factors and common factors for the original pair of numbers. Using the display, the learner must find the pair's least common multiple (LCM) and greatest common factor (GCF). Buttons allow users to check their answers and select new problems. Instructions for using the manipulative are included, along with information about factoring. The site also links to the NCTM standard for number and operations. Copyright 2005 Eisenhower National Clearinghouse

Utah State University. National Library of Virtual Manipulatives for Interactive Mathematics

2003-01-01

415

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex  

SciTech Connect

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca{sup 2+} and two Cu{sup 2+} ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Ngo, J.C.; Huang, M.; Roth, D.A.; Furie, B.C.; Furie, B. (Wyeth); (MBL)

2008-06-03

416

Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex  

SciTech Connect

Factor VIII is a procofactor that plays a critical role in blood coagulation, and is missing or defective in hemophilia A. We determined the X-ray crystal structure of B domain-deleted human factor VIII. This protein is composed of five globular domains and contains one Ca(2+) and two Cu(2+) ions. The three homologous A domains form a triangular heterotrimer where the A1 and A3 domains serve as the base and interact with the C2 and C1 domains, respectively. The structurally homologous C1 and C2 domains reveal membrane binding features. Based on biochemical studies, a model of the factor IXa-factor VIIIa complex was constructed by in silico docking. Factor IXa wraps across the side of factor VIII, and an extended interface spans the factor VIII heavy and light chains. This model provides insight into the activation of factor VIII and the interaction of factor VIIIa with factor IXa on the membrane surface.

Chi Ki Ngo,J.; Huang, M.; Roth, D.; Furie, B.; Furie, B.

2008-01-01

417

Factors affecting reciprocating compressor performance  

SciTech Connect

A reciprocating compressor is a positive displacement machine and, in principal, its capacity and horsepower can be calculated very easily. In practice, however, several loss mechanisms act to decrease capacity and increase horsepower from the ideal predicted values. Many of these effects are quite difficult to predict accurately and the only effective way of developing reciprocating compressor performance prediction methods is to run a large number of tests on different compressors under different operating conditions. Combined with an understanding of the physics controlling the losses, experimental results allow good empirical models of losses to be developed. However, without the benefit of a good understanding of the physics of the loss mechanisms, it is impossible to interpret test results. Some factors affecting the magnitude of losses are compressor design, compressor speed, suction and discharge pressure and temperature, gas composition, suction and discharge piping design, and valve design. Losses that are important in some applications may be negligible in others so it is essential that a wide range of compressor designs, valve designs, gas molecular weight and operating conditions be tested when developing a performance prediction model. The paper discusses the effects of clearance and pressure ratio; the primary losses affecting capacity and power, including valve and port pressure loss, valve springing, valve inertia, piston ring leakage, packing leakage, discharge valve leakage, suction valve leakage, pulsations, heat transfer in the suction passage, and heat transfer in the cylinder; heat transfer in compressor cylinders; performance prediction methods; and compressor diagnosis.

Woollatt, D. (Dresser-Rand Co., Painted Post, NY (United States))

1993-06-01

418

Tissue factor: mechanisms of decryption.  

PubMed

It is generally believed that only a small fraction of the tissue factor (TF) found on cell surfaces is active whereas the vast majority is cryptic in coagulation. It is unclear how cryptic TF differs from the coagulant active TF or potential mechanisms involved in transformation of cryptic TF to the coagulant active form. Exposure of phosphatidylserine (PS) in response to various chemical or pathophysiological stimuli has been considered as the most potent inducer of TF decryption. In addition to PS, TF self-association and association with specialized membrane domains may also play a role in TF decryption. It has been suggested recently that protein disulfide isomerase regulates TF decryption through its oxidoreductase activity by targeting Cys186-Cys209 disulfide bond in TF extracellular domain or regulating the PS equilibrium at the plasma membrane. However, this hypothesis requires further validation to become an accepted mechanism. In this article, we critically review literature on TF encryption/decryption with specific emphasis on recently published data and provide our perspective on this subject. PMID:22201972

Rao, L Vijaya Mohan; Kothari, Hema; Pendurthi, Usha R

2012-01-01

419

Purification & Characterization of Transcription Factors  

PubMed Central

Transcription factors (TFs) are essential for the expression of all proteins, including those involved in human health and disease. However, TFs are resistant to proteomic characterization because they are frequently masked by more abundant proteins due to the limited dynamic range of capillary liquid chromatography-tandem mass spectrometry and protein database searching. Purification methods, particularly strategies that exploit the high affinity of TFs for DNA response elements on gene promoters, can enrich TFs prior to proteomic analysis to improve dynamic range and penetrance of the TF proteome. For example, trapping of TF complexes specific for particular response elements has been achieved by recovering the element DNA-protein complex on solid supports. Additional methods for improving dynamic range include two- and three-dimensional gel electrophoresis incorporating electrophoretic mobility shift assays and Southwestern blotting for detection. Here we review methods for TF purification and characterization. We fully expect that future investigations will apply these and other methods to illuminate this important but challenging proteome. PMID:23832591

Nagore, LI; Nadeau, RJ; Guo, Q; Jadhav, YLA; Jarrett, HW; Haskins, WE

2013-01-01

420

Interaction of factor XIII subunits.  

PubMed

Coagulation factor XIII (FXIII) is a heterotetramer consisting of 2 catalytic A subunits (FXIII-A2) and 2 protective/inhibitory B subunits (FXIII-B2). FXIII-B, a mosaic protein consisting of 10 sushi domains, significantly prolongs the lifespan of catalytic subunits in the circulation and prevents their slow progressive activation in plasmatic conditions. In this study, the biochemistry of the interaction between the 2 FXIII subunits was investigated. Using a surface plasmon resonance technique and an enzyme-linked immunosorbent assay-type binding assay, the equilibrium dissociation constant (Kd) for the interaction was established in the range of 10(-10) M. Based on the measured Kd, it was calculated that in plasma approximately 1% of FXIII-A2 should be in free form. This value was confirmed experimentally by measuring FXIII-A2 in plasma samples immunodepleted of FXIII-A2B2. Free plasma FXIII-A2 is functionally active, and when activated by thrombin and Ca(2+), it can cross-link fibrin. In cerebrospinal fluid and tears with much lower FXIII subunit concentrations, >80% of FXIII-A2 existed in free form. A monoclonal anti-FXIII-B antibody that prevented the interaction between the 2 subunits reacted with the recombinant combined first and second sushi domains of FXIII-B, and its epitope was localized to the peptide spanning positions 96 to 103 in the second sushi domain. PMID:24408323

Katona, Eva; Pénzes, Krisztina; Csapó, Andrea; Fazakas, Ferenc; Udvardy, Miklós L; Bagoly, Zsuzsa; Orosz, Zsuzsanna Z; Muszbek, László

2014-03-13

421

Factors fragmenting the Russian Federation  

SciTech Connect

This paper examines the factors that threaten the future of the Russian Federation (RF). The observations are based on a study that focused on eight republics: Mordova, Udmurtia, Tatarstan, Mari El, Bashkortostan, Kabardino-Balkaria, Buryatia, and Altay Republic. These republics were selected for their geographic and economic significance to the RF. Tatarstan, Bashkortostan, Udmurtia, and Mari El are located on important supply routes, such as the Volga River and the trans-Siberian railroad. Some of these republics are relatively wealthy, with natural resources such as oil (e.g., Tatarstan and Bashkortostan), and all eight republics play significant roles in the military-industrial complex. The importance of these republics to the RF contrasts to the relative insignificance of the independence-minded Northern Caucasus area. The author chose not to examine the Northern Caucasus region (except Kabardino-Balkaria) because these republics may have only a minor impact on the rest of the RF if they secede. Their impact would be minimized because they lie on the frontiers of the RF. Many Russians believe that {open_quotes}it might be best to let such a troublesome area secede.{close_quotes}

Brown, E.

1993-10-06

422

Environmental factors in Tourette syndrome.  

PubMed

Environmental exposures during the prenatal period, perinatal stages, and postnatal life may contribute to onset and course of Tourette syndrome (TS). Pregnancy-related noxious exposures may be more frequent in pregnancies of children who will develop TS, particularly maternal smoking and prenatal life stressors. Lower birth weight and use of forceps at delivery may be associated with tic severity in the offspring; moreover, low birth weight and maternal smoking during pregnancy may affect the risk of co-morbid attention-deficit/hyperactivity and obsessive-compulsive disorders. Group A streptococcal infections as risk-modifier for TS has not been convincingly demonstrated to date, although an interaction with stressors was suggested. The PANDAS hypothesis is currently undergoing a nosological revision. Only limited anecdotal evidence supports a link of TS to other pathogens. Nevertheless, the relationship between infections and TS may be complex. Recent data point to intrinsically altered immune regulation in TS, which might predispose to both infections and autoimmune mechanisms; however, evidence of cell-mediated and antibody-mediated autoimmunity in TS is still insufficient. Psychosocial stress remains the most important contextual factor influencing tic severity, as confirmed by prospective studies. This might in part be related to enhanced reactivity of the stress response in TS patients, the mechanisms of which need to be explored further. New studies on large prospective cohorts of patients of different age and the identification of reliable biomarkers or endophenotypes indicating early, prenatal exposure to environmental insults are needed. PMID:23092654

Hoekstra, Pieter J; Dietrich, Andrea; Edwards, Mark J; Elamin, Ishraga; Martino, Davide

2013-07-01

423

Factors associated with smoking cessation  

PubMed Central

OBJECTIVE To analyze the prevalence and factors associated with smoking abstinence among patients who were treated in a reference unit for smoking cessation. METHODS This cross-sectional study examined the medical records of 532 patients treated in a reference unit for smoking cessation in Belém, PA, Northern Brazil, between January 2010 and June 2012. Sociodemographic variables and those related to smoking history and treatment were analyzed. Statistical significance was set at p < 0.05. RESULTS The mean age of the participants was 50 years; 57.0% of the patients were women. The mean tobacco load was 30 packs/year, and the mean smoking duration was approximately 32 years. Most patients remained in treatment for four months. The rate of smoking abstinence was 75.0%. Regression analysis indicated that maintenance therapy, absence of relapse triggers, and lower chemical dependence were significantly associated with smoking cessation. CONCLUSIONS The smoking abstinence rate observed was 75.0%. The cessation process was associated with several aspects, including the degree of chemical dependence, symptoms of withdrawal, and period of patient follow-up in a multidisciplinary treatment program. Studies of this nature contribute to the collection of consistent epidemiological data and are essential for the implementation of effective smoking prevention and cessation strategies. PMID:25741649

França, Samires Avelino de Souza; Neves, Ana Ligian Feitosa das; de Souza, Tatiane Andressa Santos; Martins, Nandara Celana Negreiros; Carneiro, Saul Rassy; Sarges, Edilene do Socorro Nascimento Falcão; de Souza, Maria de Fátima Amine Houat

2015-01-01

424

Human factors in agile manufacturing  

SciTech Connect

As industries position themselves for the competitive markets of today, and the increasingly competitive global markets of the 21st century, agility, or the ability to rapidly develop and produce new products, represents a common trend. Agility manifests itself in many different forms, with the agile manufacturing paradigm proposed by the Iacocca Institute offering a generally accepted, long-term vision. In its many forms, common elements of agility or agile manufacturing include: changes in business, engineering and production practices, seamless information flow from design through production, integration of computer and information technologies into all facets of the product development and production process, application of communications technologies to enable collaborative work between geographically dispersed product development team members and introduction of flexible automation of production processes. Industry has rarely experienced as dramatic an infusion of new technologies or as extensive a change in culture and work practices. Human factors will not only play a vital role in accomplishing the technical and social objectives of agile manufacturing. but has an opportunity to participate in shaping the evolution of industry paradigms for the 21st century.

Forsythe, C.

1995-03-01

425

The Gla domain of factor IXa binds to factor VIIIa in the tenase complex.  

PubMed

During blood coagulation factor IXa binds to factor VIIIa on phospholipid membranes to form an enzymatic complex, the tenase complex. To test whether there is a protein-protein contact site between the gamma-carboxyglutamic acid (Gla) domain of factor IXa and factor VIIIa, we demonstrated that an antibody to the Gla domain of factor IXa inhibited factor VIIIa-dependent factor IXa activity, suggesting an interaction of the factor IXa Gla domain with factor VIIIa. To study this interaction, we synthesized three analogs of the factor IXa Gla domain (FIX1-47) with Phe-9, Phe-25, or Val-46 replaced, respectively, with benzoylphenylalanine (BPA), a photoactivatable cross-linking reagent. These factor IX Gla domain analogs maintain native tertiary structure, as demonstrated by calcium-induced fluorescence quenching and phospholipid binding studies. In the absence of phospholipid membranes, FIX1-47 was able to inhibit factor IXa activity. This inhibition is dependent on the presence of factor VIIIa, suggesting a contact site between the factor IXa Gla domain and factor VIIIa. To demonstrate a direct interaction we did cross-linking experiments with FIX1-479BPA, FIX1-4725BPA, and FIX1-4746BPA. Covalent cross-linking to factor VIIIa was observed primarily with FIX1-4725BPA and to a much lesser degree with FIX1-4746BPA. Immunoprecipitation experiments with an antibody to the C2 domain of factor VIIIa indicate that the factor IX Gla domain cross-links to the A3-C1-C2 domain of factor VIIIa. These results suggest that the factor IXa Gla domain contacts factor VIIIa in the tenase complex through a contact site that includes phenylalanine 25 and perhaps valine 46. PMID:12782629

Blostein, Mark D; Furie, Barbara C; Rajotte, Isabelle; Furie, Bruce

2003-08-15

426

Background Bayes Factor Simulation Study BF And PPP Using Bayes Factors for Model Selection in  

E-print Network

Background Bayes Factor Simulation Study BF And PPP Using Bayes Factors for Model Selection in High-Energy Astrophysics Shandong Zhao Department of Statistic, UCI April, 2013 #12;Background Bayes Factor Simulation" to formally compare or select a model. #12;Background Bayes Factor Simulation Study BF And PPP Spectral

Wolfe, Patrick J.

427

Kinetics of Factor X activation by the membrane-bound complex of Factor IXa and Factor VIIIa.  

PubMed

Intrinsic tenase consists of activated Factors IX (IXa) and VIII (VIIIa) assembled on a negatively charged phospholipid surface. In vivo, this surface is mainly provided by activated platelets. In vitro, phosphatidylcholine/phosphatidylserine vesicles are often used to mimic natural pro-coagulant membranes. In the present study, we developed a quantitative mathematical model of Factor X activation by intrinsic tenase. We considered two situations, when complex assembly occurs on either the membrane of phospholipid vesicles or the surface of activated platelets. On the basis of existing experimental evidence, the following mechanism for the complex assembly on activated platelets was suggested: (i) Factors IXa, VIIIa and X bind to their specific platelet receptors; (ii) bound factors form complexes on the membrane: platelet-bound Factor VIIIa provides a high-affinity site for Factor X and platelet-bound Factor IXa provides a high-affinity site for Factor VIIIa; (iii) the enzyme-cofactor-substrate complex is assembled. This mechanism allowed the explanation of co-operative effects in the binding of Factors IXa, VIIIa and X to platelets. The model was reduced to obtain a single equation for the Factor X activation rate as a function of concentrations of Factors IXa, VIIIa, X and phospholipids (or platelets). The equation had a Michaelis-Menten form, where apparent V(max) and K(m) were functions of the factors' concentrations and the internal kinetic constants of the system. The equation obtained can be used in both experimental studies of intrinsic tenase and mathematical modelling of the coagulation cascade. The approach of the present study can be applied to research of other membrane-dependent enzymic reactions. PMID:15104540

Panteleev, Mikhail A; Saenko, Evgueni L; Ananyeva, Natalya M; Ataullakhanov, Fazoil I

2004-08-01

428

Dissimilar interaction of factor VIII with endothelial cells and lipid vesicles during factor X activation.  

PubMed Central

A localized and regulated cascade of proteolytic events is a prerequisite for normal haemostasis. The activation of factor X by activated factor IX (factor IXa) in the presence of activated factor VIII (factor VIIIa) is essential for the formation of a fibrin clot at sites of vascular injury. We observed sustained activation of factor X on the surface of vascular endothelial cells, whereas, in agreement with others, on synthetic negatively charged phospholipid vesicles and activated blood platelets factor X activation is transient and starts to decline a few minutes after the onset of the reaction. We examined the mechanism responsible for these differences in factor X activation. Procoagulant membrane and solution were analysed separately for the occurrence of factor VIII and its activation fragments. On negatively charged phospholipid vesicles, on dissociation of factor VIIIa, the 67 kDa light-chain fragment remains associated with the lipid membrane. As a result, factor VIII-binding sites remain occupied, and dampening of factor X activation occurs. In contrast, on monolayers of endothelial cells, no residual factor VIIIa fragments associated with the cell membrane were observed. During endothelial-cell-mediated activation of factor X, accumulation of factor VIIIa fragments was observed in the solution phase only. This finding suggests that, on endothelial cells, factor VIII-binding sites remain accessible for further factor VIII binding, guaranteeing sustained activation of factor X. These data demonstrate that the nature of the procoagulant membrane contributes to the regulation of the cofactor activity of factor VIII and thereby affects the progress of factor X activation. PMID:9169607

Brinkman, H J; Koster, P; Mertens, K; van Mourik, J A

1997-01-01

429

Evolution of general transcription factors.  

PubMed

Three genes GTF2IRD1, GTF2I, and GTF2IRD2, which encode members of the GTF2I (or TFII-I) family of so-called general transcription factors, were discovered and studied during the last two decades. Chromosome location and similarity of exon-intron structures suggest that the family evolved by duplications. The initial duplication of ancestral proto-GTF2IRD1 gene likely occurred in early vertebrates prior to origin of cartilaginous fish and led to formation of GTF2I (>450 MYA), which was later lost in bony fish but successfully evolved in the land vertebrates. The second duplication event, which created GTF2IRD2, occurred prior to major radiation events of eutherian mammalian evolution (>100 MYA). During recent steps of primate evolution there was another duplication which led to formation of GTF2IRD2B (<4 MYA). Two latest duplications were coupled with inversions. Genes belonging to the family have several highly conservative repeats which are implicated in DNA binding. Phylogenetic analysis of the repeats revealed a pattern of intragenic duplications, deletions and substitutions which led to diversification of the genes and proteins. Distribution of statistically rare atypical substitutions (p ? 0.01) sheds some light on structural differentiation of repeats and hence evolution of the genes. The atypical substitutions are often located on secondary structures joining ?-helices and affect 3D arrangement of the protein globule. Such substitutions are commonly traced at the early stages of evolution in Tetrapoda, Amniota, and Mammalia. PMID:23229069

Gunbin, K V; Ruvinsky, A

2013-02-01

430

Sulfation of von Willebrand factor  

SciTech Connect

von Willebrand factor (vWF) is a multimeric adhesive glycoprotein essential for normal hemostasis. We have discovered that cultured human umbilical vein endothelial cells incorporate inorganic sulfate into vWF. Following immunoisolation and analysis by polyacrylamide or agarose gel electrophoresis, metabolically labeled vWF was found to have incorporated (35S)-sulfate into all secreted multimer species. The time course of incorporation shows that sulfation occurs late in the biosynthesis of vWF, near the point at which multimerization occurs. Quantitative analysis suggests the presence, on average, of one molecule of sulfate per mature vWF subunit. Virtually all the detectable sulfate is released from the mature vWF subunit by treatment with endoglycosidases that remove asparagine-linked carbohydrates. Sulfated carbohydrate was localized first to the N-terminal half of the mature subunit (amino acids 1 through 1,365) by partial proteolytic digestion with protease V8; and subsequently to a smaller fragment within this region (amino acids 273 through 511) by sequential digestions with protease V8 and trypsin. Thus, the carbohydrate at asparagine 384 and/or 468 appears to be the site of sulfate modification. Sodium chlorate, an inhibitor of adenosine triphosphate-sulfurylase, blocks sulfation of vWF without affecting either the ability of vWF to assemble into high molecular weight multimers or the ability of vWF multimers to enter Weible-Palade bodies. The stability of vWF multimers in the presence of an endothelial cell monolayer also was unaffected by the sulfation state. Additionally, we have found that the cleaved propeptide of vWF is sulfated on asparagine-linked carbohydrate.

Carew, J.A.; Browning, P.J.; Lynch, D.C. (Harvard Medical School, Boston, MA (USA))

1990-12-15

431

Ephemeral gully: soil control factors  

NASA Astrophysics Data System (ADS)

Soil erosion on hillslopes has been divided traditionally into sheet, rill, and (ephemeral) gully erosion. In sheet erosion, a relatively shallow overland flow acts on a hillslope and removes sediment particles uniformly from the land surface. Usually, rill erosion occur in uncertain points within sloping surfaces, whereas gullies occur in more specific places in the landscapes, i.e., within topographic swales or hollows. So that, current models for prediction of (ephemeral) gully initiation and development rely mainly on topographic factors while soil conditions are almost neglected. However, the assessment of the erodibility of soil materials is essential for analyzing and properly modeling gully erosion. But, despite the wealth of studies to characterize soil vulnerability to (gully) erosion, a universal approach is still lacking. This is due to the complexity of soil conditions and erosion phenomenon and their interactions. A useful and feasible soil characterization for gully erosion prediction at large scale should be based on simple, quick, repeatable and relatively inexpensive tests to perform. This work proposes a methodology for conducting simple tests in the field and laboratory to detect soil conditions prone to gully initiation. This approach for assessing soil erodibility includes the use of vane shear apparatus, penetrometers and a mini-rain simulator as well as some current (modified) laboratory tests for assessing soil crustability and erodibility. A pool of simple soil variables to assess soils prone to gully development is proposed. Among the main variables we have the granulometric composition of the top soil (textural fractions and gravel), organic matter content, soil cohesiveness and relative sensitivity of topsoils for crusting. Our finding may be particularly useful for erosion modelling when gully initiation and development do not largely rely on topographic features but in soil conditions.

Ollobarren, Paul; Giménez, Rafael; Ángel Campo, Miguel; Casalí, Javier

2014-05-01

432

Roles for Growth Factors in Cancer Progression  

NSDL National Science Digital Library

Under physiological conditions, cells receive fate-determining signals from their tissue surroundings, primarily in the form of polypeptide growth factors. Integration of these extracellular signals underlies tissue homeostasis. Although departure from homeostasis and tumor initiation are instigated by oncogenic mutations rather than by growth factors, the latter are the major regulators of all subsequent steps of tumor progression, namely clonal expansion, invasion across tissue barriers, angiogenesis, and colonization of distant niches. Here, we discuss the relevant growth factor families, their roles in tumor biology, as well as the respective downstream signaling pathways. Importantly, cancer-associated activating mutations that impinge on these pathways often relieve, in part, the reliance of tumors on growth factors. On the other hand, growth factors are frequently involved in evolvement of resistance to therapeutic regimens, which extends the roles for polypeptide factors to very late phases of tumor progression and offers opportunities for cancer therapy.

Esther Witsch (Weizmann Institute of Science)

2010-04-01

433

The Q-factor of flexure membranes  

NASA Astrophysics Data System (ADS)

We report on the intrinsic or material quality factor (Q-factor) of a number of different materials, possible suited for the construction of low loss flexures. Clamped foil flexure membranes made from titanium, a glassy alloy, Cusil and Havar (high strength non-magnetic alloy), as well as monolithic flexure membranes made from titanium, niobium and Marval 18 (maraging) steel, have been tested. The results show that the highest intrinsic Q-factor occurs for monolithic flexure membranes constructed from niobium, with maraging steel also yielding a high intrinsic Q-factor. Other materials tested were shown to be significantly inferior. For a pendulum of mass 10 kg, with a stress safety factor of ? = 0.3, we predict a maximum Q-factor of 3.1×107 for a niobium flexure, and 2.9×106 for a maraging steel flexure.

Baker, M.; Ju, L.; Blair, D. G.

2001-10-01

434

Development of an Integrated Human Factors Toolkit  

NASA Technical Reports Server (NTRS)

An effective integration of human abilities and limitations is crucial to the success of all NASA missions. The Integrated Human Factors Toolkit facilitates this integration by assisting system designers and analysts to select the human factors tools that are most appropriate for the needs of each project. The HF Toolkit contains information about a broad variety of human factors tools addressing human requirements in the physical, information processing and human reliability domains. Analysis of each tool includes consideration of the most appropriate design stage, the amount of expertise in human factors that is required, the amount of experience with the tool and the target job tasks that are needed, and other factors that are critical for successful use of the tool. The benefits of the Toolkit include improved safety, reliability and effectiveness of NASA systems throughout the agency. This report outlines the initial stages of development for the Integrated Human Factors Toolkit.

Resnick, Marc L.

2003-01-01

435

Transcriptional factors, Mafs and their biological roles  

PubMed Central

The Maf family of transcription factors is characterized by a typical bZip structure; these transcription factors act as important regulators of the development and differentiation of many organs and tissues, including the kidney. The Maf family consists of two subgroups that are characterized according to their structure: large Maf transcription factors and small Maf transcription factors. The large Maf subgroup consists of four proteins, designated as MAFA, MAFB, c-MAF and neural retina-specific leucine zipper. In particular, MAFA is a distinct molecule that has been attracting the attention of researchers because it acts as a strong transactivator of insulin, suggesting that Maf transcription factors are likely to be involved in systemic energy homeostasis. In this review, we focused on the regulation of glucose/energy balance by Maf transcription factors in various organs. PMID:25685288

Tsuchiya, Mariko; Misaka, Ryoichi; Nitta, Kosaku; Tsuchiya, Ken

2015-01-01

436

Exploratory Bi-Factor Analysis: The Oblique Case  

ERIC Educational Resources Information Center

Bi-factor analysis is a form of confirmatory factor analysis originally introduced by Holzinger and Swineford ("Psychometrika" 47:41-54, 1937). The bi-factor model has a general factor, a number of group factors, and an explicit bi-factor structure. Jennrich and Bentler ("Psychometrika" 76:537-549, 2011) introduced an exploratory form of bi-factor…

Jennrich, Robert I.; Bentler, Peter M.

2012-01-01

437

Design and Synthesis of Binding Growth Factors  

PubMed Central

Growth factors play important roles in tissue regeneration. However, because of their instability and diffusible nature, improvements in their performance would be desirable for therapeutic applications. Conferring binding affinities would be one way to improve their applicability. Here we review techniques for conjugating growth factors to polypeptides with particular affinities. Conjugation has been designed at the level of gene fusion and of polypeptide ligation. We summarize and discuss the designs and applications of binding growth factors prepared by such conjugation approaches. PMID:22754349

Tada, Seiichi; Kitajima, Takashi; Ito, Yoshihiro

2012-01-01

438

Macroeconomic news and risk factor innovations  

Microsoft Academic Search

Purpose – The purpose of this paper is to determine if macroeconomic announcements affect the Fama-French market, size, book-to-market risk factors and momentum factor. Design\\/methodology\\/approach – Using unexpected announcements of major macroeconomic indicators, a study is made of how daily innovations of risk factors react to macroeconomic shocks. In a Flannery and Protopapadakis framework, the impact of macroeconomics surprises on

Thomas Gosnell; Ali Nejadmalayeri

2010-01-01

439

Multifactor Expectation Maximization for Factor Graphs  

Microsoft Academic Search

\\u000a Factor graphs allow large probability distributions to be stored efficiently and facilitate fast computation of marginal probabilities,\\u000a but the difficulty of training them has limited their use. Given a large set of data points, the training process should yield\\u000a factors for which the observed data has a high likelihood. We present a factor graph learning algorithm which on each iteration

Jason T. Rolfe; Matthew Cook

2010-01-01

440

Neurotrophic Factors and Diabetic Peripheral Neuropathy  

Microsoft Academic Search

Recent evidence from animal models of diabetes and human diabetic subjects suggests that the reduced availability of neurotrophic factors may contribute to the pathogenesis of diabetic peripheral neuropathy (DPN). Of these proteins, nerve growth factor (NGF), brain-derived neurotrophic factor, neurotrophin (NT-3) and NT-4\\/5 appear to be important for the development and maintenance of peripheral neurons, but others, including insulin-like growth

Stuart C. Apfel

1999-01-01

441

Synthetic heparin-binding growth factor analogs  

DOEpatents

The invention provides synthetic heparin-binding growth factor analogs having at least one peptide chain that binds a heparin-binding growth factor receptor, covalently bound to a hydrophobic linker, which is in turn covalently bound to a non-signaling peptide that includes a heparin-binding domain. The synthetic heparin-binding growth factor analogs are useful as soluble biologics or as surface coatings for medical devices.

Pena, Louis A.; Zamora, Paul; Lin, Xinhua; Glass, John D.

2007-01-23

442

Create Prime Factorization Trees with Little Alchemy  

NSDL National Science Digital Library

This lesson plan provides steps for using the open sandbox game Little Alchemy to teach Prime Factorization Trees. Little Alchemy is available as a free download or it can be opened in a webpage. The lesson plans includes a 3-minute video on how to create elements using the game. In addition to students making factor trees they can extend this lesson to write prime factorization in exponential form.

Agustin Molfino

2013-04-16

443

Influence of dietary factors on calcium bioavailability  

Microsoft Academic Search

There are several factors that affected calcium bioavailability, such as physiological and dietary factors. These dietary\\u000a factors help to achieve an appropiate status of calcium for a correct bone mineralization. In this pathway, recently some\\u000a compounds present in milk that seem improve calcium absorption such as lactose and certain caseinophosphopeptides formed during\\u000a digestion of caseins have been studied. On the

F. Cámara-Martos; M. A. Amaro-López

2002-01-01

444

Factorization of the tenth Fermat number  

Microsoft Academic Search

We describe the complete factorization of the tenth Fermat num- ber F10 by the elliptic curve method (ECM). F10 is a product of four prime factors with 8, 10, 40 and 252 decimal digits. The 40-digit factor was found after about 140 Mflop-years of computation. We also discuss the complete fac- torization of other Fermat numbers by ECM, and summarize

Richard P. Brent

1999-01-01

445

Human Factors Considerations in System Design  

NASA Technical Reports Server (NTRS)

Human factors considerations in systems design was examined. Human factors in automated command and control, in the efficiency of the human computer interface and system effectiveness are outlined. The following topics are discussed: human factors aspects of control room design; design of interactive systems; human computer dialogue, interaction tasks and techniques; guidelines on ergonomic aspects of control rooms and highly automated environments; system engineering for control by humans; conceptual models of information processing; information display and interaction in real time environments.

Mitchell, C. M. (editor); Vanbalen, P. M. (editor); Moe, K. L. (editor)

1983-01-01

446

Factors affecting the lipase activity of milk  

E-print Network

FACTORS AFFECTING THE LIPASE ACTIVITY OF MILK A Thesis By PAUL THOMAS TALLAMY Submitted to the Graduate College of Texas A&M University in partial fulfillment of the requirements for the degree of MASTER OF SCIENCE January 1969 Major... Subject: Food Technology FACTORS AFFECTING THE LIPASE ACTIVITY OF MILK A Thesis By PAUL THOMAS TALLAMY Approved as to style and content by: Chairman of Commi tee fg M ber Head f Depar tmen Mem er Member January 1969 ABSTRACT Factors Affecting...

Tallamy, Paul Thomas

1969-01-01

447

Neuronal growth factors, neurotrophins and memory deficiency  

Microsoft Academic Search

CNS and PNS ontogenesis are regulated by various proteic factors, and the best characterized of which still remains Nerve Growth Factor (NGF), a molecule exerting trophic, tropic (i.e. directing growing axons toward NGF-releasing target tissue) and differentiative effects on a number of neural and non-neural (e.g. mast-cells) cell lines. Other Growth Factors (GFs), called ‘neurotrophins’ (BDNF, NT-3, NT-4, NT-5) also

Gemma Calamandrei; Enrico Alleva

1995-01-01

448

Characterization of groundwater contamination using factor analysis  

Microsoft Academic Search

The effluent contamination of groundwater at two industrial sites at Visakhapatnam, India, was studied using factor analysis.\\u000a Thirty groundwater samples near a zinc smelter plant and 19 from the polymers plant were analyzed for specific conductance,\\u000a chloride, bicarbonate, sulfate, calcium, magnesium, sodium, and potassium. The data were subjected to R-mode factor analysis\\u000a and the factor scores transferred to areal maps.

C. Subbarao; N. V. Subbarao; S. N. Chandu

1996-01-01

449

Congenital Thrombotic Risk Factors in ?-Thalassemia  

Microsoft Academic Search

Thalassemia major patients have increased risk for thromboembolic complications because of the chronic hypercoagulable state. The question arising from this is whether thromboembolic complications are the result of genetic polymorphisms of prothrombotic factors. Here, we studied factor V 1691 G-A (FVL), factor II polymorphism (G20210A), methyltetrahydrofolate reductase mutation (MTHFR, C677T), and endothelial cell protein C receptor (EPCR) deletion polymorphism and

Tansu Sipahi; Asl?han Kara; Ayca Kuybulu; Yonca Egin; Nejat Akar

2009-01-01

450

Human Monocytes Support Factor X Activation by Factor VIIa, Independent of Tissue Factor: Implications for the Therapeutic Mechanism of High-Dose Factor VIIa in Hemophilia  

Microsoft Academic Search

bosis to complicate its use. These complications are seen when preparations of the activated vitamin-K-dependent coagulation proteins, such as Autoplex, are used to treat pa- tients with inhibitors. High-dose factor VIIa therapy has not shown a propensity to initiate DIC or thrombosis in clinical trial^.^ Factor VIIa can activate factor X in vitro in the pres- ence of phospholipid vesicles

Maureane Hoffman; Dougald M. Monroe; Harold R. Roberts

1994-01-01

451

Human factors and safety in emergency medicine  

NASA Technical Reports Server (NTRS)

A model based on an input process and outcome conceptualisation is suggested to address safety-relevant factors in emergency medicine. As shown in other dynamic and demanding environments, human factors play a decisive role in attaining high quality service. Attitudes held by health-care providers, organisational shells and work-cultural parameters determine communication, conflict resolution and workload distribution within and between teams. These factors should be taken into account to improve outcomes such as operational integrity, job satisfaction and morale.

Schaefer, H. G.; Helmreich, R. L.; Scheidegger, D.

1994-01-01

452

Erosion—diagnosis and risk factors  

Microsoft Academic Search

Dental erosion is a multifactorial condition: The interplay of chemical, biological and behavioural factors is crucial and\\u000a helps explain why some individuals exhibit more erosion than others. The erosive potential of erosive agents like acidic drinks\\u000a or foodstuffs depends on chemical factors, e.g. pH, titratable acidity, mineral content, clearance on tooth surface and on\\u000a its calcium-chelation properties. Biological factors such

A. Lussi; T. Jaeggi

2008-01-01

453

Factors associated with smoking cessation.  

PubMed

OBJECTIVE To analyze the prevalence and factors associated with smoking abstinence among patients who were treated in a reference unit for smoking cessation. METHODS This cross-sectional study examined the medical records of 532 patients treated in a reference unit for smoking cessation in Belém, PA, Northern Brazil, between January 2010 and June 2012. Sociodemographic variables and those related to smoking history and treatment were analyzed. Statistical significance was set at p < 0.05. RESULTS The mean age of the participants was 50 years; 57.0% of the patients were women. The mean tobacco load was 30 packs/year, and the mean smoking duration was approximately 32 years. Most patients remained in treatment for four months. The rate of smoking abstinence was 75.0%. Regression analysis indicated that maintenance therapy, absence of relapse triggers, and lower chemical dependence were significantly associated with smoking cessation. CONCLUSIONS The smoking abstinence rate observed was 75.0%. The cessation process was associated with several aspects, including the degree of chemical dependence, symptoms of withdrawal, and period of patient follow-up in a multidisciplinary treatment program. Studies of this nature contribute to the collection of consistent epidemiological data and are essential for the implementation of effective smoking prevention and cessation strategies.OBJETIVO Analisar a prevalência e fatores associados à abstinência tabágica entre pacientes atendidos em unidade de referência para cessação do tabagismo. MÉTODOS Estudo transversal que analisou 532 prontuários de pacientes atendidos em unidade de referência para cessação do tabagismo em Belém, PA, entre janeiro de 2010 e junho de 2012. Foram analisadas variáveis sociodemográficas e aquelas relacionadas à história tabágica e ao tratamento realizado. Considerou-se para significância estatística p < 0,05. RESULTADOS A média de idade dos participantes foi 50 anos e cerca de 57,0% dos pacientes eram do sexo feminino. A carga tabágica média foi 30 maços/ano e o tempo médio de tabagismo foi aproximadamente 32 anos. A maioria dos pacientes permaneceram em tratamento por quatro meses. A taxa de abstinência tabágica foi 75,0%. Na análise de regressão, terapia de manutenção, ausência de gatilhos de recaída e dependência química mais baixa foram significativamente associados à cessação. CONCLUSÕES A taxa de abstinência tabágica observada foi 75,0%. O processo de cessação associou-se a diversos aspectos, como grau de dependência química, sintomas de abstinência e tempo de acompanhamento do paciente em um programa de tratamento multiprofissional. Estudos desta natureza, portanto, auxiliam na reunião de informações epidemiológicas consistentes, fundamentais à elaboração de ações de prevenção e combate ao tabagismo mais efetivas. PMID:25741649

França, Samires Avelino de Souza; Neves, Ana Ligian Feitosa das; Souza, Tatiane Andressa Santos de; Martins, Nandara Celana Negreiros; Carneiro, Saul Rassy; Sarges, Edilene do Socorro Nascimento Falcão; Souza, Maria de Fátima Amine Houat de

2015-01-01

454

Matrix factorization on a hypercube multiprocessor  

SciTech Connect

This paper is concerned with parallel algorithms for matrix factorization on distributed-memory, message-passing multiprocessors, with special emphasis on the hypercube. Both Cholesky factorization of symmetric positive definite matrices and LU factorization of nonsymmetric matrices using partial pivoting are considered. The use of the resulting triangular factors to solve systems of linear equations by forward and back substitutions is also considered. Efficiencies of various parallel computational approaches are compared in terms of empirical results obtained on an Intel iPSC hypercube. 19 refs., 6 figs., 2 tabs.

Geist, G.A.; Heath, M.T.

1985-08-01

455

How is impact factor impacting our research?  

PubMed

The impact factor (IF) of an journal is a measure reflecting the average number of citations to recent articles published in the journal. It is frequently used as a proxy for the relative importance of a journal within its field, with journals with higher impact factors deemed to be more important than those with lower ones. However it is not a perfect metric and has its own limitations. Journals are increasingly finding new ways to improve their impact factor by increasing self citation, publishing more review articles. This correspondence discuss the fallacies of the impact factor. PMID:25179695

Rawat, Seema

2014-01-01

456

CIMGS: An incomplete orthogonal factorization preconditioner  

SciTech Connect

This paper introduces, analyzes, and tests a preconditioning method for conjugate gradient (CG) type iterative methods. The authors start by examining incomplete Gram-Schmidt factorization (IGS) methods in order to motivate the new preconditioner. They show that the IGS family is more stable than IC, and they successfully factor any full rank matrix. Furthermore, IGS preconditioners are at least as effective in accelerating convergence of CG type iterative methods as the incomplete Cholesky (IC) preconditioner. The drawback of IGS methods are their high cost of factorization. This motivates finding a new algorithm, CIMGS, which can generate the same factor in a more efficient way.

Wang, X.; Bramley, R. [Indiana Univ., Bloomington, IN (United States); Gallivan, K. [Univ. of Illinois, Urbana, IL (United States)

1994-12-31

457

Standardisation of the factor H autoantibody assay.  

PubMed

The screening of all atypical haemolytic uraemic syndrome (aHUS) patients for factor H autoantibodies is best practice. However, there is no consensus assay for the reporting of factor H autoantibody titres. In this study, three European complement laboratories with expertise in the field of autoantibody testing address this by systematically evaluating several ELISA methods used for the detection of factor H autoantibodies. All methods tested adequately detect high titre samples. However, this study recommends the Paris method for the detection and reporting of factor H autoantibodies to be used when setting up a factor H autoantibody screen. The importance of individual sample background subtraction in these ELISA tests was established. The use of a relative or arbitrary unit index with a common positive and negative serum allowed for consistent comparison of findings from different test centres. Therefore, it is recommended that a standard arbitrary unit scale based on a titration curve from a common positive anti-serum be adopted to allow future establishment of the relative importance of particular titres of factor H autoantibodies in aHUS. Systematic assay for the presence of factor H autoantibodies in patients using the Paris method will provide the longitudinal analysis needed to fully establish the importance of factor H autoantibodies in disease. This will feed into additional research to clarify whether additional factors have a bearing on the phenotype/outcome of autoimmune aHUS. PMID:23891327

Watson, Rachael; Lindner, Susanne; Bordereau, Pauline; Hunze, Eva-Maria; Tak, Federico; Ngo, Stéphanie; Zipfel, Peter F; Skerka, Christine; Dragon-Durey, Marie-Agnes; Marchbank, Kevin J

2014-01-01

458

SCIENCE CAF Bioengineering: The XX Factor  

E-print Network

SCIENCE CAFÃ? Bioengineering: The XX Factor How does gender affect the health, injury and treatment Assistant Professor, Department of Civil Engineering and Centre for Bioengineering Research and Education

Garousi, Vahid

459

NASA information sciences and human factors program  

NASA Technical Reports Server (NTRS)

The FY-90 descriptions of technical accomplishments are contained in seven sections: Automation and Robotics, Communications, Computer Sciences, Controls and Guidance, Data Systems, Human Factors, and Sensor Technology.

Holcomb, Lee; Hood, Ray; Montemerlo, Melvin; Jenkins, James; Smith, Paul; Dibattista, John; Depaula, Ramon; Hunter, Paul; Lavery, David

1991-01-01

460

History and evolution of buildup factors  

SciTech Connect

The gamma-ray buildup factor is a term whose origin is lost in the mists of the early history of the Manhattan Project.' Its introduction stems from the observation that the calculations for the uncollided photons, i.e., those that have arrived at R without suffering any collisions, are usually a relatively simple matter, involving only an exponential kernel. The buildup factor is then a multiplicative factor, which corrects the answer that is proportional to the uncollided flux density to include the effects of the scattered photons. This paper further summarizes and traces efforts since 1954 at calculating and mathematically defining buildup factors.

Trubey, D.K.

1992-01-01

461

Factor XI and XII as antithrombotic targets  

PubMed Central

Purpose of review Arterial and venous thrombosis are major causes of morbidity and mortality, and the incidence of thromboembolic diseases increases as a population ages. Thrombi are formed by activated platelets and fibrin. The latter is a product of the plasma coagulation system. Currently available anticoagulants such as heparins, vitamin K antagonists and inhibitors of thrombin or factor Xa target enzymes of the coagulation cascade that are critical for fibrin formation. However, fibrin is also necessary for terminating blood loss at sites of vascular injury. As a result, anticoagulants currently in clinical use increase the risk of bleeding, partially offsetting the benefits of reduced thrombosis. This review focuses on new targets for anticoagulation that are associated with minimal or no therapy-associated increased bleeding. Recent findings Data from experimental models using mice and clinical studies of patients with hereditary deficiencies of coagulation factors XI or XII have shown that both of these clotting factors are important for thrombosis, while having minor or no apparent roles in processes that terminate blood loss (hemostasis). Summary Hereditary deficiency of factor XII (Hageman factor) or factor XI, plasma proteases that initiate the intrinsic pathway of coagulation, impairs thrombus formation and provides protection from vascular occlusive events, while having a minimal impact on hemostasis. As the factor XII–factor XI pathway contributes to thrombus formation to a greater extent than to normal hemostasis, pharmacological inhibition of these coagulation factors may offer the exciting possibility of anticoagulation therapies with minimal or no bleeding risk. PMID:21730835

Müller, Felicitas; Gailani, David; Renné, Thomas

2015-01-01

462

[Motoneuronal cell death and neurotrophic factors].  

PubMed

At early developmental stages, the survival of motoneurons is maintained by some as yet unidentified neurotrophic factors derived from their target muscles. As the animal matures, motoneuronal survival becomes less dependent on the innervated muscle. Yet, the dependence of motoneuronal survival on the target muscle does not abolish completely even in adults. In man, more than 50% of the lumbar motoneurons die several years after leg amputation. Thus, in principle, motoneuron disease can result from prolonged impairment of the neurotrophic supply from the target muscle. Several candidates have been proposed for the trophic factor of motoneurons; these include CNTF (ciliary neurotrophic factor), the FGF (fibroblast growth factor) family, the neurotrophin family and CADF (choline acetyltransferase development factor). CNTF is now considered to be a lesion factor rather than a neurotrophic factor. In the FGF family, FGF-5 remains as a possible neurotrophic factor for motoneurons. Three neurotrophins, BDNF (brain-derived neurotrophic factor), neurotrophin 3 (NT-3) and NT-5, may support the survival of both sensory neurons and motoneurons. CADF is a strong candidate, but its primary structure remains unknown. PMID:8174324

Kuno, M

1993-12-01

463

NASA Information Sciences and Human Factors Program  

NASA Technical Reports Server (NTRS)

Fiscal year 1989 descriptions of technical accomplishments in seven sections are presented: automation and robotics; communications; computer sciences; controls and guidance; data systems; human factors; and sensor technology.

Holcomb, Lee; Hood, Ray; Montemerlo, Melvin; Jenkins, James; Smith, Paul; Dibattista, John; Depaula, Ramon; Hunter, Paul

1990-01-01

464

Proteomic methodologies to study transcription factor function  

PubMed Central

Transcription factors regulate transcription by binding to regulatory regions of genes including the promoter. Few of the transcription factors are well characterized and few promoters have been described in detail. New methods have been developed to improve both transcription factor and promoter characterization, some of which are discussed here. Trapping methodology applicable to both individual transcription factors and intact transcription complexes are described, as well as 2-dimensional gel electrophoresis, Southwestern blotting, and basic liquid chromatography/tandem mass spectrometry methodology. These methods have proved useful in the study of transcriptional regulation. PMID:21938635

Jarrett, Harry W.

2012-01-01

465

Factors Contributing to Crashes among Young Drivers  

PubMed Central

Young drivers are the group of drivers most likely to crash. There are a number of factors that contribute to the high crash risk experienced by these drivers. While some of these factors are intrinsic to the young driver, such as their age, gender or driving skill, others relate to social factors and when and how often they drive. This article reviews the factors that affect the risk of young drivers crashing to enable a fuller understanding of why this risk is so high in order to assist in developing effective countermeasures. PMID:25097763

Bates, Lyndel J.; Davey, Jeremy; Watson, Barry; King, Mark J.; Armstrong, Kerry

2014-01-01

466

Tumor-necrosis-factor-induced fibroblast growth factor-1 acts as a survival factor in a transformed endothelial cell line.  

PubMed Central

Endothelial cells undergo apoptosis after withdrawal of growth factors, alterations in the extracellular matrix, or exposure to cytokines. Here we report that tumor necrosis factor (TNF)-alpha induces apoptosis of human endothelial cells derived from the umbilical vein in a dose-dependent fashion. Apoptosis is triggered through a pathway that is independent from the levels of Bcl-2. On the contrary, TNF stimulates the growth of spontaneously transformed human umbilical vein endothelial cells. This proliferative effect is mediated through the up-regulation of fibroblast growth factor-1 by TNF. The addition of specific fibroblast growth factor-1 antisense oligonucleotides inhibits TNF-induced fibroblast growth factor-1 expression, thus inhibiting the growth and triggering apoptosis of spontaneously transformed human umbilical vein endothelial cells. Images Figure 2 Figure 3 Figure 4 Figure 5 Figure 7 PMID:8780398

Maier, J. A.; Morelli, D.; Ménard, S.; Colnaghi, M. I.; Balsari, A.

1996-01-01

467

Factor I is required for the development of membranoproliferative glomerulonephritis in factor H–deficient mice  

PubMed Central

The inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) is associated with dysregulation of the alternative pathway of complement activation. MPGN2 is characterized by the presence of complement C3 along the glomerular basement membrane (GBM). Spontaneous activation of C3 through the alternative pathway is regulated by 2 plasma proteins, factor H and factor I. Deficiency of either of these regulators results in uncontrolled C3 activation, although the breakdown of activated C3 is dependent on factor I. Deficiency of factor H, but not factor I, is associated with MPGN2 in humans, pigs, and mice. To explain this discordance, mice with single or combined deficiencies of these factors were studied. MPGN2 did not develop in mice with combined factor H and I deficiency or in mice deficient in factor I alone. However, administration of a source of factor I to mice with combined factor H and factor I deficiency triggered both activated C3 fragments in plasma and GBM C3 deposition. Mouse renal transplant studies demonstrated that C3 deposited along the GBM was derived from plasma. Together, these findings provide what we believe to be the first evidence that factor I–mediated generation of activated C3 fragments in the circulation is a critical determinant for the development of MPGN2 associated with factor H deficiency. PMID:18202746

Rose, Kirsten L.; Paixao-Cavalcante, Danielle; Fish, Jennifer; Manderson, Anthony P.; Malik, Talat H.; Bygrave, Anne E.; Lin, Tao; Sacks, Steven H.; Walport, Mark J.; Cook, H. Terence; Botto, Marina; Pickering, Matthew C.

2008-01-01

468

Regulation of Growth Factor Receptors by Gangliosides  

NSDL National Science Digital Library

Growth factor receptors are important in controlling many cellular functions, such as growth, differentiation, and disease. Growth factor receptors activate numerous signal transduction pathways within cells; however, how one growth factor receptor orchestrates multiple signal transduction pathways is not clear. This review focuses on a ubiquitous component of the plasma membrane, called "gangliosides," and how they modulate growth factor receptors at the cell membrane. Gangliosides are complex structures that consist of two parts--a lipid ceramide moiety and a carbohydrate head structure. Studies over the past two decades have demonstrated that different gangliosides can enhance or inhibit growth factor receptor activity. However, ganglioside modulation of growth factor receptors is more complex than simply stimulation or inhibition. We present and discuss three models of how gangliosides regulate growth factor receptors: (i) modulation of ligand binding, (ii) regulation of receptor dimerization, and (iii) regulation of receptor activation state and subcellular distribution. On the basis of these models, we speculate about the physiological consequences of ganglioside regulation of growth factor receptors.

Erik A. Miljan (Chicago; Children's Memorial Medical Center REV)

2002-11-26

469

Quality factor control for micromechanical resonators  

Microsoft Academic Search

The implementation of very high Q microelectromechanical filters, constructed of spring-coupled or parallel resonators, requires strict control over the quality factor of the constituent resonators. This report details electrostatic feedback techniques which allow precise control of the quality factor of a micromechanical resonator device, independent of the ambient operating pressure of the micromechanical system. Theoretical formulas governing Q-control are derived

C. T.-C. Nguyen; R. T. Howe

1992-01-01

470

Risk factors identified for certain lymphoma subtypes  

Cancer.gov

In a large international collaborative analysis of risk factors for non-Hodgkin lymphoma (NHL), scientists were able to quantify risk associated with medical history, lifestyle factors, family history of blood or lymph-borne cancers, and occupation for 11 different NHL subtypes, including less common subtypes.

471

Psychosocial factors in juvenile diabetes: A review  

Microsoft Academic Search

Studies assessing (1) the influence of psychosocial factors on the onset of juvenile diabetes, (2) the influence of psychosocial factors on the course of this disease, and (3) the influence of diabetes on the psychosocial development of the child are reviewed. Directions for future research are suggested.

Suzanne Bennett Johnson

1980-01-01

472

Factors affecting Internet development: An Asian survey  

Microsoft Academic Search

This study examined the relationship between the Internet development and various social, economic and political factors that are hypothesized to affect the Internet growth. Using secondary data for 28 sampled Asian countries, this study tested seven hypotheses about the impact of various factors on Internet growth. The findings show that the Internet penetration is related to a country's wealth, telecommunication

Hao Xiaoming; Chow Seet Kay

2004-01-01

473

Factors of Addiction: New Jersey Correctional Population  

ERIC Educational Resources Information Center

Most state inmates incarcerated under the jurisdiction of the New Jersey Department of Corrections are driven to crimes by drug abuse. Understanding the factors contributing to addiction is the first step in developing strategies for successful inmate reintegration. This study presents an analysis of inmate addiction and factor association using…

Wojtowicz, James P.; Liu, Tongyin; Hedgpeth, G. Wayne

2007-01-01

474

Factor Scores, Structure Coefficients, and Communality Coefficients  

ERIC Educational Resources Information Center

This paper presents heuristic explanations of factor scores, structure coefficients, and communality coefficients. Common misconceptions regarding these topics are clarified. In addition, (a) the regression (b) Bartlett, (c) Anderson-Rubin, and (d) Thompson methods for calculating factor scores are reviewed. Syntax necessary to execute all four…

Goodwyn, Fara

2012-01-01

475

Factors Underlying Tongue Articulation in Speech.  

ERIC Educational Resources Information Center

Manipulation of speed of delivery and linguistic context followed by factor analysis of 11 measures of lingual activity involved in the production of the syllable /ka/ indicated three factors explained 75 percent of the variance: displacement/velocity, duration, and midsyllable duration and distance. (Author/DB)

Keller, Eric

1987-01-01

476

Strange quark contribution to nucleon form factors  

E-print Network

We discuss methods for the calculation of disconnected diagrams and their application to various form factors of the nucleon. In particular, we present preliminary results for the strange contribution to the scalar and axial form factors, calculated with N_f=2 dynamical flavors of Wilson fermions on an anisotropic lattice.

Ronald Babich; Richard Brower; Michael Clark; George Fleming; James Osborn; Claudio Rebbi

2007-10-29

477

Strange quark contribution to nucleon form factors  

E-print Network

We discuss methods for the calculation of disconnected diagrams and their application to various form factors of the nucleon. In particular, we present preliminary results for the strange contribution to the scalar and axial form factors, calculated with N_f=2 dynamical flavors of Wilson fermions on an anisotropic lattice.

Babich, R; Clark, M; Fleming, G; Osborn, J; Rebbi, C

2007-01-01

478

Family Factors Predicting Categories of Suicide Risk  

ERIC Educational Resources Information Center

We compared family risk and protective factors among potential high school dropouts with and without suicide-risk behaviors (SRB) and examined the extent to which these factors predict categories of SRB. Subjects were randomly selected from among potential dropouts in 14 high schools. Based upon suicide-risk status, 1,083 potential high school…

Randell, Brooke P.; Wang, Wen-Ling; Herting, Jerald R.; Eggert, Leona L.

2006-01-01

479

Cellular Factors Required for Lassa Virus Budding  

Microsoft Academic Search

It is known that Lassa virus Z protein is sufficient for the release of virus-like particles (VLPs) and that it has two L domains, PTAP and PPPY, in its C terminus. However, little is known about the cellular factor for Lassa virus budding. We examined which cellular factors are used in Lassa virus Z budding. We demonstrated that Lassa Z

S. Urata; T. Noda; Yoshihiro Kawaoka; Hideyoshi Yokosawa; Jiro Yasuda

2006-01-01

480

Sequential addition of reprogramming factors improves efficiency.  

PubMed

Addition of a specific set of transcription factors reprograms somatic cell nuclei to a pluripotent state. Sequential addition of these factors, rather than the simultaneous exposure used in standard protocols, improves reprogramming efficiency. This sequential method favours a transition through a state with enhanced mesenchymal characteristics before driving an epithelial transformation on the way to the pluripotent state. PMID:23817236

Gaeta, X; Xie, Y; Lowry, W E

2013-07-01

481

FACTORS AFFECTING AURAL DETECTIONS OF SONGBIRDS  

Microsoft Academic Search

Many factors affect the number of birds detected on point count surveys of breeding songbirds. The magnitude and importance of these factors are not well understood. We used a bird song simulation system to quantify the effects of detection distance, singing rate, species differences, and observer differences on detection probabilities of birds detected by ear. We simulated 40 point counts

Mathew W. Alldredge; Theodore R. Simons; Kenneth H. Pollock

2007-01-01

482

Factors Affecting Turkish Students' Achievement in Mathematics  

ERIC Educational Resources Information Center

Following past researches, student background, learning strategies, self-related cognitions in mathematics and school climate variables were important for achievement. The purpose of this study was to identify a number of factors that represent the relationship among sets of interrelated variables using principal component factor analysis and…

Demir, Ibrahim; Kilic, Serpil; Depren, Ozer

2009-01-01

483

Osteoporosis Risk Factors in Eighth Grade Students.  

ERIC Educational Resources Information Center

Presents findings from food frequency questionnaires and surveys of 138 Midwestern eighth-grade student-parent pairs. The study examined the incidence of modifiable and nonmodifiable osteoporosis risk factors and compared gender differences. Data analysis indicated that many adolescents possessed several modifiable and nonmodifiable risk factors…

Lysen, Victoria C.; Walker, Robert

1997-01-01

484

Contributions to Factor Analysis of Dichotomous Variables.  

ERIC Educational Resources Information Center

A new method--similar to Christoffersson's--for the factor analysis of dichotomous variables uses information from the first and second order proportions to fit a multiple factor model. The estimation is considerably simplified. Items from Rotter's locus of control inventory are included. (Author/JKS)

Muthen, Bengt

1978-01-01

485

Plant Selection Factors The City of  

E-print Network

Plant Selection Factors The City of OKLAHOMA CITY UTILITIES DEPARTMENT Oklahoma Cooperative-433 #12;Plan Before you Plant Plants add value to the home, provide shade, define space, and make us happy. Consider the following five plant selection factors when choosing plants for your landscape. Keep

Balasundaram, Balabhaskar "Baski"

486

Quadratic Equations: From Factored to Standard Form  

NSDL National Science Digital Library

This activity leads students to understand the utility in the factored form of a quadratic equation. Students then express quadratic equations in standard form in the corresponding factored form. The activity is concluded with four critical-thinking questions. website: http://www.mathedpage.org/ copyright information: http://www.mathedpage.org/rights.html

2011-01-01

487

Factors Associated with Eating Disorders in Women  

Microsoft Academic Search

Although various factors associated with eating disorders have been studied, no comprehensive source of research findings was identified in this review. The purpose of this study was to identify and synthesize research findings of factors associated with eating disorders in women published from 1992-2008. These findings may be useful to nurses, other professionals, families, and the public to facilitate the

Christina Knowles; Faculty Mentor; Frances Smith

488

Developmental Risk Factors for Sexual Offending.  

ERIC Educational Resources Information Center

A study involving 64 Australian sex offenders and 33 non-sex offenders found childhood emotional abuse and family dysfunction, childhood behavior problems, and childhood sexual abuse were developmental risk factors for paraphilia. Emotional abuse and family dysfunction was found to be a risk factor for pedophilia, exhibitionism, rape, or multiple…

Lee, Joseph K. P.; Jackson, Henry J.; Pattison, Pip; Ward, Tony

2002-01-01

489

Risk Factors for Anterior Cruciate Ligament Injury  

PubMed Central

Context: Injuries to the anterior cruciate ligament (ACL) are immediately disabling and are associated with long-term consequences, such as posttraumatic osteoarthritis. It is important to have a comprehensive understanding of all possible risk factors for ACL injury to identify individuals who are at risk for future injuries and to provide an appropriate level of counseling and programs for prevention. Objective: This review, part 2 of a 2-part series, highlights what is known and still unknown regarding hormonal, genetic, cognitive function, previous injury, and extrinsic risk factors for ACL injury. Data Sources: Studies were identified from MEDLINE (1951–March 2011) using the MeSH terms anterior cruciate ligament, knee injury, and risk factors. The bibliographies of relevant articles and reviews were cross-referenced to complete the search. Study Selection: Prognostic case-control and prospective cohort study designs to evaluate risk factors for ACL injury were included in this review. Results: A total of 50 case-control and prospective cohort articles were included in parts 1 and 2. Twenty-one focused on hormonal, genetic, cognitive function, previous injury, and extrinsic risk factors. Conclusions: Several risk factors are associated with increased risk of suffering ACL injury—such as female sex, prior reconstruction of the ACL, and familial predisposition. These risk factors most likely act in combination with the anatomic factors reviewed in part 1 of this series to influence the risk of suffering ACL injury. PMID:23016083

Smith, Helen C.; Vacek, Pamela; Johnson, Robert J.; Slauterbeck, James R.; Hashemi, Javad; Shultz, Sandra; Beynnon, Bruce D.

2012-01-01

490

How Student Satisfaction Factors Affect Perceived Learning  

ERIC Educational Resources Information Center

Data from students in two sections of a general education course offered at a research university in spring 2009 were used to explore whether student satisfaction factors are associated with perceived learning as rated by students. A list of 22 elements in the learning environment was explored. The 22 were used in creating 3 satisfaction factors…

Lo, Celia C.

2010-01-01

491

Factors Influencing Career Choice among Police Recruits  

ERIC Educational Resources Information Center

This quantitative, non-experimental study examined the career choice factors of 154 (n = 154) police recruits to determine a correlation of age group generation to the five career choice factors presented in the Sibson Reward of Work Model. Law enforcement agencies faced a shortage of viable candidates to fill vacant positions. While extensive…

Cole, Bryan

2012-01-01

492

Information as An Important Production Factor.  

ERIC Educational Resources Information Center

This paper focuses on the importance of information and documentation (I&D) as one of the essential production factors in pharmaceutical industrial activities. The need for and use of I&D services depends far more on such factors as product profile, decision making processes within the organization, and ownership than on the size of the companies…

Ljungberg, Sixten

493

Cloud Controlling Factors --Low Clouds BJORN STEVENS,  

E-print Network

Cloud Controlling Factors -- Low Clouds BJORN STEVENS, Department of Atmospheric and Oceanic) clouds is reviewed, with an emphasis on factors that may be expected to change in a changing climate of low-cloud control- ling processes are offered: these include renewing our focus on theory, model

Stevens, Bjorn

494

Dietary Research - Risk Factor Monitoring & Methods Branch  

Cancer.gov

Diet, in all its complexity, is considered one of the major risk factors for cancer and is therefore a primary area of research within the Risk Factor Monitoring and Methods Branch. We work collaboratively with a wide range of researchers to conduct an integrated program that serves NCI as well as the extramural community.

495

Risk Factor Intervention for Health Maintenance  

ERIC Educational Resources Information Center

Risk factors for disease consist of personal habits such as cigarette smoking and excessive alcohol consumption, and bodily characteristics such as hypertension and high serum cholesterol. Progress in identifying, quantifying, and controlling risk factors is opening the way to the prevention of disease. (BB)

Breslow, Lester

1978-01-01

496

Critical success factors for risk management systems  

Microsoft Academic Search

Despite the existence of extensive literature regarding risk management, there still seems to be lack of knowledge in the identification of critical success factors (CSFs) in this area. In this research, grounded theory is implemented to identify CSFs in risk management systems (RMS). Factor analysis and one?sample t?tests are then used to refine and rank the CSFs on the basis

Niam Yaraghi; Roland G. Langhe

2011-01-01

497

Factors that Influence Participation in Online Learning  

ERIC Educational Resources Information Center

This study explored what factors influenced learner participation in two sections of a graduate online course at a Midwestern university. Findings indicated that online learner participation and patterns of participation are influenced by the following factors: technology and interface characteristics, content area experience, student roles and…

Vonderwell, Selma; Zachariah, Sajit

2005-01-01

498

Nerve growth factor: from neurotrophin to neurokine  

Microsoft Academic Search

Nerve growth factor (NGF) is largely known as a target-derived factor responsible for the survival and maintenance of the phenotype of specific subsets of peripheral neurones and basal forebrain cholinergic nuclei during development and maturation. However, NGF also exerts a modulatory role on sensory, nociceptive nerve physiology during adulthood that appears to correlate with hyperalgesic phenomena occurring in tissue inflammation.

Rita Levi-Montalcini; Stephen D. Skaper; Roberto Dal Toso; Lucia Petrelli; Alberta Leon

1996-01-01

499

Dynamic Factor Copula Model Ken Jackson  

E-print Network

The Gaussian factor copula model is the market standard model for multi-name credit derivatives. Its main drawback is that factor copula models exhibit correlation smiles when calibrating against market tranche to be time- dependent, and hence they are allowed to follow certain stochastic processes. Therefore, we can

Toronto, University of

500

Analytic Dynamic Factor Copula Model Ken Jackson  

E-print Network

Abstract The Gaussian factor copula model is the market standard model for multi-name credit derivatives market tranche quotes. To overcome the calibration defi- ciency, we introduce a multi-period factor are allowed to be time- dependent, and hence they are allowed to follow certain stochastic processes

Toronto, University of