Science.gov

Sample records for clinical empirical studies

  1. Current Clinical Interventions for Smoking Cessation: A Review of Empirical Studies.

    ERIC Educational Resources Information Center

    Marcellino, Robert Leonard, Jr.

    This document reviews all empirical studies on clinically-based smoking cessation interventions that were reported in "Psychological Abstracts" between January 1982 and March 1990. Interventions are categorized as either physiological or psychological in orientation and are further grouped according to specific treatment type: acupuncture,…

  2. Empirical studies of clinical supervision in psychiatric nursing: A systematic literature review and methodological critique.

    PubMed

    Buus, Niels; Gonge, Henrik

    2009-08-01

    The objective of this paper was to systematically review and critically evaluate all English language research papers reporting empirical studies of clinical supervision in psychiatric nursing. The first part of the search strategy was a combination of brief and building block strategies in the PubMed, CINAHL, and PsycINFO databases. The second part was a citation pearl growing strategy with reviews of 179 reference lists. In total, the search strategy demonstrated a low level of precision and a high level of recall. Thirty four articles met the criteria of the review and were systematically evaluated using three checklists. The findings were summarized by using a new checklist with nine overall questions regarding the studies' design, methods, findings, and limitations. The studies were categorized as: (i) effect studies; (ii) survey studies; (iii) interview studies; and (iv) case studies. In general, the studies were relatively small scale; they used relatively new and basic methods for data collection and analysis, and rarely included sufficient strategies for identifying confounding factors or how the researchers' preconceptions influenced the analyses. Empirical research of clinical supervision in psychiatric nursing was characterized by a basic lack of agreement about which models and instruments to use. Challenges and recommendations for future research are discussed. Clinical supervision in psychiatric nursing was commonly perceived as a good thing, but there was limited empirical evidence supporting this claim. PMID:19594645

  3. The patient perspective of clinical training-an empirical study about patient motives to participate.

    PubMed

    Drevs, Florian; Gebele, Christoph; Tscheulin, Dieter K

    2014-10-01

    This study introduces a comprehensive model to explain patients' prosocial behavioral intentions to participate in clinical training. Using the helping decision model, the authors analyze the combined impact of factors that affect participation intentions. The model includes intrapersonal and interpersonal appraisals triggered by an awareness of the societal need for clinical training as a practical part of medical education. The results of our empirical study (N=317) show that personal costs and anxiety as negative appraisals and a warm glow as a positive appraisal affect participation intentions and fully mediate the effect of the patient's awareness of the societal need. The study results indicate that communication strategies should address patient beliefs about negative personal consequences of participation rather than highlighting the societal need for practical medical education related to clinical training. Based on the results, medical associations could develop guidelines and provide training for physicians on how to motivate patients to participate in clinical training, resulting in more patient-centered standardized consent discussions. PMID:24976237

  4. Attitudes toward Substance Abuse Clients: An Empirical Study of Clinical Psychology Trainees.

    PubMed

    Mundon, Chandra R; Anderson, Melissa L; Najavits, Lisa M

    2015-01-01

    Despite the high prevalence of substance use disorder (SUD) and its frequent comorbidity with mental illness, individuals with SUD are less likely to receive effective SUD treatment from mental health practitioners than SUD counselors. Limited competence and interest in treating this clinical population are likely influenced by a lack of formal training in SUD treatment. Using a factorial survey-vignette design that included three clinical vignettes and a supplementary survey instrument, we investigated whether clinical psychology doctoral students differ in their level of negative emotional reactions toward clients with SUD versus major depressive disorder (MDD); whether they differ in their attributions for SUD versus MDD; and how their negative emotional reactions and attributions impact their interest in pursuing SUD clinical work. Participants were 155 clinical psychology graduate-level doctoral students (72% female). Participants endorsed more negative emotional reactions toward clients with SUD than toward clients with MDD. They were also more likely to identify poor willpower as the cause for SUD than for MDD. More than a third reported interest in working with SUD populations. Highest levels of interest were associated with prior professional and personal experience with SUD, four to six years of clinical experience, and postmodern theoretical orientation. PMID:26375324

  5. Clinical prediction from structural brain MRI scans: a large-scale empirical study.

    PubMed

    Sabuncu, Mert R; Konukoglu, Ender

    2015-01-01

    Multivariate pattern analysis (MVPA) methods have become an important tool in neuroimaging, revealing complex associations and yielding powerful prediction models. Despite methodological developments and novel application domains, there has been little effort to compile benchmark results that researchers can reference and compare against. This study takes a significant step in this direction. We employed three classes of state-of-the-art MVPA algorithms and common types of structural measurements from brain Magnetic Resonance Imaging (MRI) scans to predict an array of clinically relevant variables (diagnosis of Alzheimer's, schizophrenia, autism, and attention deficit and hyperactivity disorder; age, cerebrospinal fluid derived amyloid-β levels and mini-mental state exam score). We analyzed data from over 2,800 subjects, compiled from six publicly available datasets. The employed data and computational tools are freely distributed ( https://www.nmr.mgh.harvard.edu/lab/mripredict), making this the largest, most comprehensive, reproducible benchmark image-based prediction experiment to date in structural neuroimaging. Finally, we make several observations regarding the factors that influence prediction performance and point to future research directions. Unsurprisingly, our results suggest that the biological footprint (effect size) has a dramatic influence on prediction performance. Though the choice of image measurement and MVPA algorithm can impact the result, there was no universally optimal selection. Intriguingly, the choice of algorithm seemed to be less critical than the choice of measurement type. Finally, our results showed that cross-validation estimates of performance, while generally optimistic, correlate well with generalization accuracy on a new dataset. PMID:25048627

  6. Defense mechanisms in congenital and acquired facial disfigurement: a clinical-empirical study.

    PubMed

    van den Elzen, Marijke E P; Versnel, Sarah L; Perry, J Christopher; Mathijssen, Irene M J; Duivenvoorden, Hugo J

    2012-04-01

    It is of clinical interest to investigate the degree to which patients with facial disfigurement use defense styles. Therefore, 59 adults born with rare facial clefts, 59 patients with facial deformities acquired at an adult age, and a reference group of 141 adults without facial disfigurements completed standardized questionnaires. There was a significant difference between the group with and the group without disfigurements on immature defense styles, with the disfigured group using the immature style more frequently. There was a trend for the nondisfigured group to use more mature defense styles. No difference between congenital and acquired groups was seen on individual types of defense style. Self-esteem had the strength to differentiate mature and immature defense styles within our disfigured groups. The association of low self-esteem and the utilization of immature defense styles suggests that professional help may tailor treatment on discussing immature defense style and problems triggering or maintaining this style. PMID:22456586

  7. Informing sequential clinical decision-making through reinforcement learning: an empirical study

    PubMed Central

    Shortreed, Susan M.; Laber, Eric; Lizotte, Daniel J.; Stroup, T. Scott; Pineau, Joelle; Murphy, Susan A.

    2011-01-01

    This paper highlights the role that reinforcement learning can play in the optimization of treatment policies for chronic illnesses. Before applying any off-the-shelf reinforcement learning methods in this setting, we must first tackle a number of challenges. We outline some of these challenges and present methods for overcoming them. First, we describe a multiple imputation approach to overcome the problem of missing data. Second, we discuss the use of function approximation in the context of a highly variable observation set. Finally, we discuss approaches to summarizing the evidence in the data for recommending a particular action and quantifying the uncertainty around the Q-function of the recommended policy. We present the results of applying these methods to real clinical trial data of patients with schizophrenia. PMID:21799585

  8. A simplified surveillance case definition of AIDS derived from empirical clinical data. The Clinical AIDS Study Group, and the Working Group on AIDS case definition.

    PubMed

    Weniger, B G; Quinhões, E P; Sereno, A B; de Perez, M A; Krebs, J W; Ismael, C; Sion, F S; Ramos-Filho, C F; de Sá, C A; Byers, R H

    1992-12-01

    A clinical AIDS case definition is needed for surveillance in countries where the CDC case definition is not practical. To derive such a definition, we compared 110 HIV-seropositive and 135 randomly selected HIV-seronegative adult medical-ward inpatients in Brazil. Multivariate analysis of clinical signs and symptoms and simple diagnoses resulted in a discriminant function with sensitivity of 89% and specificity of 96% in predicting for AIDS. These data were the empirical basis for a clinical definition of AIDS in adults drafted in a Caracas, Venezuela, workshop sponsored by the Pan American Health Organization. The revised "Caracas" definition presented here requires a positive HIV serology, the absence of cancer or other cause of immunosuppression, plus > or = 10 cumulative points, as follows: Kaposi's sarcoma (10 points); extrapulmonary/noncavitary pulmonary tuberculosis (10); oral candidiasis or hairy leukoplakia (5); cavitary pulmonary/unspecified tuberculosis (5); herpes zoster < 60 years of age (5); CNS dysfunction (5); diarrhea > or = 1 month (2); fever > or = 1 month (2); cachexia or > 10% weight loss (2); asthenia > or = 1 month (2); persistent dermatitis (2); anemia, lymphopenia, or thrombocytopenia (2); persistent cough or any pneumonia except TB (2); and lymphadenopathy > or = 1 cm at > or = 2 noninguinal sites for > or = 1 month (2). This definition has a sensitivity of 95% and a specificity of 100% (91% without HIV serology) when applied to the Brazilian patients in this study. The Caracas definition has been adopted by Brazil, Honduras, and Surinam, and is in validation elsewhere. The use of a reasonably sensitive and specific case definition commensurate with available diagnostic resources should facilitate AIDS surveillance in developing countries. PMID:1453332

  9. Students' experiences of cooperation with nurse teacher during their clinical placements: an empirical study in a Western European context.

    PubMed

    Saarikoski, Mikko; Kaila, Päivi; Lambrinou, Ekaterini; Pérez Cañaveras, Rosa Maria; Tichelaar, Erna; Tomietto, Marco; Warne, Tony

    2013-03-01

    In many European countries during the last decade, the clinical role of the nurse teacher has changed from a clinical skilled practitioner to a liaison person working between educational and health care provider organisations. This study explored pre-registration nursing students' perceptions of cooperation with nurse teachers during their clinical placements in nine Western European countries. The study also assessed the type and range of e-communication between students and nurse teachers and whom the students' perceived as their most important professional role model. The study is a descriptive survey. Quantitative data were collected from 17 higher education institutes of nursing located in the northern, middle and southern parts of Europe. The purposive sample (N = 1903) comprised students who had participated in courses which included clinical placements. The data were analysed using descriptive statistics. Comparisons between the groups were made using cross-tabulation. The majority (57%) of students met their nurse teacher 1-3 times during their placement while 13% of the students did not meet their nurse teacher at all. Additionally, 66% of respondents used some form of e-communication (e-mail, mobile text messages etc.) to communicate with their nurse teacher. It is important to clarify the division of labour between nurse teachers and Mentors. There are both opportunities and challenges in how to utilise information technology to more effectively promote cooperation between students and nurse teachers. PMID:22902569

  10. Empirically supported psychological treatments: the challenge of evaluating clinical innovations.

    PubMed

    Church, Dawson; Feinstein, David; Palmer-Hoffman, Julie; Stein, Phyllis K; Tranguch, Anthony

    2014-10-01

    Clear and transparent standards are required to establish whether a therapeutic method is "evidence based." Even when research demonstrates a method to be efficacious, it may not become available to patients who could benefit from it, a phenomenon known as the "translational gap." Only 30% of therapies cross the gap, and the lag between empirical validation and clinical implementation averages 17 years. To address these problems, Division 12 of the American Psychological Association published a set of standards for "empirically supported treatments" in the mid-1990s that allows the assessment of clinical modalities. This article reviews these criteria, identifies their strengths, and discusses their impact on the translational gap, using the development of a clinical innovation called Emotional Freedom Techniques (EFT) as a case study. Twelve specific recommendations for updates of the Division 12 criteria are made based on lessons garnered from the adoption of EFT within the clinical community. These recommendations would shorten the cycle from the research setting to clinical practice, increase transparency, incorporate recent scientific advances, and enhance the capacity for succinct comparisons among treatments. PMID:25265265

  11. The Clinical Assessment in the Legal Field: An Empirical Study of Bias and Limitations in Forensic Expertise

    PubMed Central

    Iudici, Antonio; Salvini, Alessandro; Faccio, Elena; Castelnuovo, Gianluca

    2015-01-01

    According to the literature, psychological assessment in forensic contexts is one of the most controversial application areas for clinical psychology. This paper presents a review of systematic judgment errors in the forensic field. Forty-six psychological reports written by psychologists, court consultants, have been analyzed with content analysis to identify typical judgment errors related to the following areas: (a) distortions in the attribution of causality, (b) inferential errors, and (c) epistemological inconsistencies. Results indicated that systematic errors of judgment, usually referred also as “the man in the street,” are widely present in the forensic evaluations of specialist consultants. Clinical and practical implications are taken into account. This article could lead to significant benefits for clinical psychologists who want to deal with this sensitive issue and are interested in improving the quality of their contribution to the justice system. PMID:26648892

  12. Evaluating the quality of informed consent and contemporary clinical practices by medical doctors in South Africa: An empirical study

    PubMed Central

    2013-01-01

    Background Informed consent is a legal and ethical doctrine derived from the principle of respect for autonomy. Generally two rights derived from autonomy are accorded legal protection. The constitutional right to bodily integrity followed by the right to bodily well-being, protected by professional negligence rules. Therefore healthcare professionals treating patients' without valid consent may be guilty of infringing patients' rights. Many challenges are experienced by doctors obtaining informed consent in complex multicultural societies like South Africa. These include different cultural ethos, multilingualism, poverty, education, unfamiliarity with libertarian rights based autonomy, and power asymmetry between doctors and patients. All of which could impact on the ability of doctors to obtain legally valid informed consent. Methods The objective of this study was to evaluate whether the quality of informed consent obtained by doctors practicing in South Africa is consistent with international ethical standards and local regulations. Responses from 946 participants including doctors, nurses and patients was analyzed, using a semi-structured self-administered questionnaire and person triangulation in selected public hospitals in Durban, KwaZulu-Natal, South Africa. Results The median age of 168 doctors participating was 30 years with 51% females, 28% interns, 16% medical officers, 26% registrars, 30% consultant/specialists. A broad range of clinical specialties were represented. Challenges to informed consent practice include language difficulties, lack of interpreters, workload, and time constraints. Doctors spent 5-10 minutes on consent, disclosed most information required to patients, however knowledge of essential local laws was inadequate. Informed consent aggregate scores (ICAS) showed that interns/registrars scored lower than consultants/specialists. ICAS scores were statistically significant by specialty (p = 0.005), with radiologists and anaesthetists

  13. Direct Contra Naïve-Indirect Comparison of Clinical Failure Rates between High-Viscosity GIC and Conventional Amalgam Restorations: An Empirical Study

    PubMed Central

    Mickenautsch, Steffen; Yengopal, Veerasamy

    2013-01-01

    Background Naïve-indirect comparisons are comparisons between competing clinical interventions’ evidence from separate (uncontrolled) trials. Direct comparisons are comparisons within randomised control trials (RCTs). The objective of this empirical study is to test the null-hypothesis that trends and performance differences inferred from naïve-indirect comparisons and from direct comparisons/RCTs regarding the failure rates of amalgam and direct high-viscosity glass-ionomer cement (HVGIC) restorations in permanent posterior teeth have similar direction and magnitude. Methods A total of 896 citations were identified through systematic literature search. From these, ten and two uncontrolled clinical longitudinal studies for HVGIC and amalgam, respectively, were included for naïve-indirect comparison and could be matched with three out twenty RCTs. Summary effects sizes were computed as Odds ratios (OR; 95% Confidence intervals) and compared with those from RCTs. Trend directions were inferred from 95% Confidence interval overlaps and direction of point estimates; magnitudes of performance differences were inferred from the median point estimates (OR) with 25% and 75% percentile range, for both types of comparison. Mann-Whitney U test was applied to test for statistically significant differences between point estimates of both comparison types. Results Trends and performance differences inferred from naïve-indirect comparison based on evidence from uncontrolled clinical longitudinal studies and from direct comparisons based on RCT evidence are not the same. The distributions of the point estimates differed significantly for both comparison types (Mann–Whitney U  =  25, nindirect  =  26; ndirect  =  8; p  =  0.0013, two-tailed). Conclusion The null-hypothesis was rejected. Trends and performance differences inferred from either comparison between HVGIC and amalgam restorations failure rates in permanent posterior teeth are not the same. It is

  14. The Empirical Status of Empirically Supported Psychotherapies: Assumptions, Findings, and Reporting in Controlled Clinical Trials

    ERIC Educational Resources Information Center

    Westen, Drew; Novotny, Catherine M.; Thompson-Brenner, Heather

    2004-01-01

    This article provides a critical review of the assumptions and findings of studies used to establish psychotherapies as empirically supported. The attempt to identify empirically supported therapies (ESTs) imposes particular assumptions on the use of randomized controlled trial (RCT) methodology that appear to be valid for some disorders and…

  15. Satanism among Adolescents: Empirical and Clinical Considerations.

    ERIC Educational Resources Information Center

    Steck, Gary M.; And Others

    1992-01-01

    Reviews literature on adolescent involvement in satanism. Presents results from a pilot study along with a case study to illustrate factors that may alert practitioners to adolescents who are susceptible to satanic influences. Discusses interventions for dealing with this adolescent subpopulation. (Author/NB)

  16. Satanism among adolescents: empirical and clinical considerations.

    PubMed

    Steck, G M; Anderson, S A; Boylin, W M

    1992-01-01

    This paper reviews the literature on adolescent involvement in satanism. Results from a pilot study are presented along with a case study to illustrate factors that may alert practitioners to adolescents who are susceptible to satanic influences. Interventions for dealing with this adolescent subpopulation are discussed. PMID:1471568

  17. Developing an empirical base for clinical nurse specialist education.

    PubMed

    Stahl, Arleen M; Nardi, Deena; Lewandowski, Margaret A

    2008-01-01

    This article reports on the design of a clinical nurse specialist (CNS) education program using National Association of Clinical Nurse Specialists (NACNS) CNS competencies to guide CNS program clinical competency expectations and curriculum outcomes. The purpose is to contribute to the development of an empirical base for education and credentialing of CNSs. The NACNS CNS core competencies and practice competencies in all 3 spheres of influence guided the creation of clinical competency grids for this university's practicum courses. This project describes the development, testing, and application of these clinical competency grids that link the program's CNS clinical courses with the NACNS CNS competencies. These documents guide identification, tracking, measurement, and evaluation of the competencies throughout the clinical practice portion of the CNS program. This ongoing project will continue to provide data necessary to the benchmarking of CNS practice competencies, which is needed to evaluate the effectiveness of direct practice performance and the currency of graduate nursing education. PMID:18438164

  18. Comparative Case Study of Diffusion of Eye Movement Desensitization and Reprocessing in Two Clinical Settings: Empirically Supported Treatment Status Is Not Enough

    PubMed Central

    Cook, Joan M.; Biyanova, Tatyana; Coyne, James C.

    2013-01-01

    An in-depth comparative case study was conducted of two attempts at diffusion of an empirically supported, but controversial, psychotherapy: eye movement desensitization and reprocessing (EMDR). One Department of Veterans Affairs (VA) treatment setting in which there was substantial uptake was compared with a second VA setting in which it was not adopted. Qualitative interviews were conducted with 10 mental health clinicians at the first site, and 19 at the second. Critical selling points for EMDR were a highly regarded champion, the observability of effects with patients, and personally experiencing its effects during a role training session. Compatibility with existing psychotherapist practices and values further allowed the therapy to become embedded in the organizational culture. At the second site, a sense that EMDR was not theoretically coherent or compelling overwhelmed other considerations, including its empirical status. Comparative studies contrasting settings in which innovative therapies are implemented versus those in which they were rejected may aid in refining theories of and strategies for dissemination. PMID:25360060

  19. Clinical Findings and Pain Symptoms as Potential Risk Factors for Chronic TMD: Descriptive Data and Empirically Identified Domains from the OPPERA Case-Control Study

    PubMed Central

    Ohrbach, Richard; Fillingim, Roger B.; Mulkey, Flora; Gonzalez, Yoly; Gordon, Sharon; Gremillion, Henry; Lim, Pei-Feng; Ribeiro-Dasilva, Margarete; Greenspan, Joel D.; Knott, Charles; Maixner, William; Slade, Gary

    2011-01-01

    Clinical characteristics might be associated with temporomandibular disorders (TMD) because they are antecedent risk factors that increase the likelihood of a healthy person developing the condition or because they represent signs or symptoms of either subclinical or overt TMD. In this baseline case-control study of the multisite Orofacial Pain: Prospective Evaluation and Risk Assessment (OPPERA) project, 1,633 controls and 185 cases with chronic, painful TMD completed questionnaires and received clinical examinations. Odds ratios measuring association between each clinical factor and TMD were computed, with adjustment for study-site as well as age, sex, and race/ethnicity. Compared to controls, TMD cases reported more trauma, greater parafunction, more headaches and other pain disorders, more functional limitation in using the jaw, more nonpain symptoms in the facial area, more temporomandibular joint noises and jaw locking, more neural or sensory medical conditions, and worse overall medical status. They also exhibited on examination reduced jaw mobility, more joint noises, and a greater number of painful masticatory, cervical, and body muscles upon palpation. The results indicated that TMD cases differ substantially from controls across almost all variables assessed. Future analyses of follow-up data will determine whether these clinical characteristics predict increased risk for developing first-onset pain-related TMD Perspective Clinical findings from OPPERA’s baseline case-control study indicate significant differences between chronic TMD cases and controls with respect to trauma history, parafunction, other pain disorders, health status, and clinical examination data. Future analyses will examine their contribution to TMD onset. PMID:22074750

  20. Overexcitabilities: Empirical Studies and Application

    ERIC Educational Resources Information Center

    Chang, Hsin-Jen; Kuo, Ching-Chih

    2013-01-01

    Ever since Dr. Dabrowski raised his theory of positive disintegration, several studies focusing on overexcitabilities (OEs) have been performed. This study reviewed previous findings on overexcitabilities and their application, focusing in particular on studies in Taiwan. Since 2001, a series of studies related to overexcitabilities has been…

  1. Teaching Clinical Interviewing in the Health Professions: A Review of Empirical Research.

    ERIC Educational Resources Information Center

    Carroll, J. Gregory; Monroe, Judy

    1980-01-01

    A review of 36 empirical studies on teaching interviewing skills in various health profession programs is presented. The focus is on teaching skills which consider the interpersonal skills relevant to effective clinical interviewing. Programs are compared and implications for future research are discussed. (GDC)

  2. Characterizing Student Expectations: A Small Empirical Study

    ERIC Educational Resources Information Center

    Warwick, Jonathan

    2016-01-01

    This paper describes the results of a small empirical study (n = 130), in which undergraduate students in the Business Faculty of a UK university were asked to express views and expectations relating to the study of a mathematics. Factor analysis is used to identify latent variables emerging from clusters of the measured variables and these are…

  3. An empirical investigation of the structure of anxiety and depressive symptoms in late adolescence: cross-sectional study using the Greek version of the revised Clinical Interview Schedule.

    PubMed

    Skapinakis, Petros; Anagnostopoulos, Fotios; Bellos, Stefanos; Magklara, Konstantina; Lewis, Glyn; Mavreas, Venetsanos

    2011-04-30

    Several studies in the past have examined whether the hierarchical structure of anxiety and depressive symptoms can explain the high comorbidity between them but more studies are needed from other settings and with different methods. The present study aimed to examine the structure of common anxiety and depressive symptoms in adolescents 16-18 years old attending secondary schools using the Greek version of the revised Clinical Interview Schedule (CIS-R), a fully structured psychiatric interview. A total of 2431 adolescents were interviewed with the computerized version of the CIS-R. The hierarchical structure of 12 depressive and anxiety symptoms was examined with confirmatory factor analytical methods. Four alternative models of increasing complexity were tested. The best-fitting model included three first-order factors, representing the dimensions of anxiety, depression and non-specific distress respectively. A model with a higher-order factor representing the broader internalizing dimension was less supported by the data. The findings of this and other studies should be taken into account in future classifications of psychiatric disorders and may have clinical practical implications. PMID:20846727

  4. Self-Disorders and Clinical High Risk for Psychosis: An Empirical Study in Help-Seeking Youth Attending Community Mental Health Facilities.

    PubMed

    Raballo, Andrea; Pappagallo, Elena; Dell' Erba, Alice; Lo Cascio, Nella; Patane', Martina; Gebhardt, Eva; Boldrini, Tommaso; Terzariol, Laura; Angelone, Massimiliano; Trisolini, Alberto; Girardi, Paolo; Fiori Nastro, Paolo

    2016-07-01

    Anomalous subjective experiences involving an alteration of the basic sense of self (ie, Self-disorder [SD]) are emerging as a core marker of schizophrenia spectrum disorders with potential impact on current early detection strategies as well. In this study, we wished to field-test the prevalence of SD in a clinical sample of adolescent/young adult help-seekers at putative risk for psychosis attending standard community mental health facilities in Italy. Participants (n = 47), aged between 14 and 25, underwent extensive psychopathological evaluations with current semi-structured tools to assess Clinical High Risk (CHR) state (ie, Structured Interview for Prodromal Syndromes/Scale of Prodromal Symptoms [SIPS/SOPS], Schizophrenia Proneness Instrument-Adult/Child and Youth [SPI-A/CY]). SD aggregated in CHR subjects as compared to the non-CHR and revealed substantial association with sub-psychotic symptoms (SIPS), subjective experience of cognitive and cognitive-perceptual vulnerability (basic symptoms) and functional level (Global Assessment of functioning). Moreover, a combination of the 2 approaches (ie, CHR plus SD) enabled further "closing-in" on a subgroup of CHR with lower global functioning. The results confirm SD's relevance for the early profiling of youths at potential high risk for psychosis. PMID:26757754

  5. Empiric Antibiotic Treatment of Erythema Migrans-Like Skin Lesions As a Function of Geography: A Clinical and Cost Effectiveness Modeling Study

    PubMed Central

    Brinkerhoff, R. Jory; Wormser, Gary P.; Clemen, Robert

    2013-01-01

    Abstract The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appropriate in regions where Lyme disease is rare. We constructed a decision model to compare the cost and clinical effectiveness of three strategies for the management of EM: Treat All, Observe, and Serology as a function of the probability that an EM-like lesion is Lyme disease. Treat All was found to be the preferred strategy in regions that are endemic for Lyme disease. Where Lyme disease is rare, Observe is the preferred strategy, as presumptive treatment would be expected to produce excessive harm and increased costs. Where Lyme disease is rare, clinicians and public health officials should consider observing patients with EM-like lesions who lack travel to Lyme disease-endemic areas. PMID:24107201

  6. Empiric antibiotic treatment of erythema migrans-like skin lesions as a function of geography: a clinical and cost effectiveness modeling study.

    PubMed

    Lantos, Paul M; Brinkerhoff, R Jory; Wormser, Gary P; Clemen, Robert

    2013-12-01

    The skin lesion of early Lyme disease, erythema migrans (EM), is so characteristic that routine practice is to treat all such patients with antibiotics. Because other skin lesions may resemble EM, it is not known whether presumptive treatment of EM is appropriate in regions where Lyme disease is rare. We constructed a decision model to compare the cost and clinical effectiveness of three strategies for the management of EM: Treat All, Observe, and Serology as a function of the probability that an EM-like lesion is Lyme disease. Treat All was found to be the preferred strategy in regions that are endemic for Lyme disease. Where Lyme disease is rare, Observe is the preferred strategy, as presumptive treatment would be expected to produce excessive harm and increased costs. Where Lyme disease is rare, clinicians and public health officials should consider observing patients with EM-like lesions who lack travel to Lyme disease-endemic areas. PMID:24107201

  7. Identifying Conditions That Support Causal Inference in Observational Studies in Education: Empirical Evidence from within Study Comparisons

    ERIC Educational Resources Information Center

    Hallberg, Kelly

    2013-01-01

    This dissertation is a collection of three papers that employ empirical within study comparisons (WSCs) to identify conditions that support causal inference in observational studies. WSC studies empirically estimate the extent to which a given observational study reproduces the result of a randomized clinical trial (RCT) when both share the same…

  8. An empirical study of software design practices

    NASA Technical Reports Server (NTRS)

    Card, David N.; Church, Victor E.; Agresti, William W.

    1986-01-01

    Software engineers have developed a large body of software design theory and folklore, much of which was never validated. The results of an empirical study of software design practices in one specific environment are presented. The practices examined affect module size, module strength, data coupling, descendant span, unreferenced variables, and software reuse. Measures characteristic of these practices were extracted from 887 FORTRAN modules developed for five flight dynamics software projects monitored by the Software Engineering Laboratory (SEL). The relationship of these measures to cost and fault rate was analyzed using a contingency table procedure. The results show that some recommended design practices, despite their intuitive appeal, are ineffective in this environment, whereas others are very effective.

  9. Transition mixing study empirical model report

    NASA Technical Reports Server (NTRS)

    Srinivasan, R.; White, C.

    1988-01-01

    The empirical model developed in the NASA Dilution Jet Mixing Program has been extended to include the curvature effects of transition liners. This extension is based on the results of a 3-D numerical model generated under this contract. The empirical model results agree well with the numerical model results for all tests cases evaluated. The empirical model shows faster mixing rates compared to the numerical model. Both models show drift of jets toward the inner wall of a turning duct. The structure of the jets from the inner wall does not exhibit the familiar kidney-shaped structures observed for the outer wall jets or for jets injected in rectangular ducts.

  10. Evolution of viral virulence: empirical studies

    USGS Publications Warehouse

    Kurath, Gael; Wargo, Andrew R.

    2016-01-01

    The concept of virulence as a pathogen trait that can evolve in response to selection has led to a large body of virulence evolution theory developed in the 1980-1990s. Various aspects of this theory predict increased or decreased virulence in response to a complex array of selection pressures including mode of transmission, changes in host, mixed infection, vector-borne transmission, environmental changes, host vaccination, host resistance, and co-evolution of virus and host. A fundamental concept is prediction of trade-offs between the costs and benefits associated with higher virulence, leading to selection of optimal virulence levels. Through a combination of observational and experimental studies, including experimental evolution of viruses during serial passage, many of these predictions have now been explored in systems ranging from bacteriophage to viruses of plants, invertebrates, and vertebrate hosts. This chapter summarizes empirical studies of viral virulence evolution in numerous diverse systems, including the classic models myxomavirus in rabbits, Marek's disease virus in chickens, and HIV in humans. Collectively these studies support some aspects of virulence evolution theory, suggest modifications for other aspects, and show that predictions may apply in some virus:host interactions but not in others. Finally, we consider how virulence evolution theory applies to disease management in the field.

  11. Empathy in Narcissistic Personality Disorder: From Clinical and Empirical Perspectives

    PubMed Central

    Baskin-Sommers, Arielle; Krusemark, Elizabeth; Ronningstam, Elsa

    2015-01-01

    Narcissistic personality disorder (NPD) is associated with an assortment of characteristics that undermine interpersonal functioning. A lack of empathy is often cited as the primary distinguishing feature of NPD. However, clinical presentations of NPD suggest that empathy is not simply deficient in these individuals, but dysfunctional and subject to a diverse set of motivational and situational factors. Consistent with this presentation, research illustrates that empathy is multidimensional, involving 2 distinct emotional and cognitive processes associated with a capacity to respectively understand and respond to others’ mental and affective states. The goal of this practice review is to bridge the gap between our psychobiological understanding of empathy and its clinical manifestations in NPD. We present 3 case studies highlighting the variability in empathic functioning in people with NPD. Additionally, we summarize the literature on empathy and NPD, which largely associates this disorder with deficient emotional empathy, and dysfunctional rather than deficient cognitive empathy. Because this research is limited, we also present empathy-based findings for related syndromes (borderline and psychopathy). Given the complexity of narcissism and empathy, we propose that multiple relationships can exist between these constructs. Ultimately, by recognizing the multifaceted relationship between empathy and narcissism, and moving away from an all or nothing belief that those with NPD simply lack empathy, therapists may better understand narcissistic patients’ behavior and motivational structure. PMID:24512457

  12. Empathy in narcissistic personality disorder: from clinical and empirical perspectives.

    PubMed

    Baskin-Sommers, Arielle; Krusemark, Elizabeth; Ronningstam, Elsa

    2014-07-01

    Narcissistic personality disorder (NPD) is associated with an assortment of characteristics that undermine interpersonal functioning. A lack of empathy is often cited as the primary distinguishing feature of NPD. However, clinical presentations of NPD suggest that empathy is not simply deficient in these individuals, but dysfunctional and subject to a diverse set of motivational and situational factors. Consistent with this presentation, research illustrates that empathy is multidimensional, involving 2 distinct emotional and cognitive processes associated with a capacity to respectively understand and respond to others' mental and affective states. The goal of this practice review is to bridge the gap between our psychobiological understanding of empathy and its clinical manifestations in NPD. We present 3 case studies highlighting the variability in empathic functioning in people with NPD. Additionally, we summarize the literature on empathy and NPD, which largely associates this disorder with deficient emotional empathy, and dysfunctional rather than deficient cognitive empathy. Because this research is limited, we also present empathy-based findings for related syndromes (borderline and psychopathy). Given the complexity of narcissism and empathy, we propose that multiple relationships can exist between these constructs. Ultimately, by recognizing the multifaceted relationship between empathy and narcissism, and moving away from an all or nothing belief that those with NPD simply lack empathy, therapists may better understand narcissistic patients' behavior and motivational structure. PMID:24512457

  13. Clinical response and hospital costs associated with the empirical use of vancomycin and linezolid for hospital-acquired pneumonia in a Chinese tertiary care hospital: a retrospective cohort study

    PubMed Central

    Song, Yuanlin; Yang, Yicheng; Chen, Wendong; Liu, Wei; Wang, Kai; Li, Xuehai; Wang, Ke; Papadimitropoulos, Manny; Montgomery, William

    2014-01-01

    Aims To evaluate clinical outcomes and allocation of hospital costs associated with empirical use of vancomycin or linezolid for hospital-acquired pneumonia (HAP) in the People’s Republic of China. Methods Hospital episodes including HAP treated by vancomycin or linezolid between 2008 and 2012 in a Chinese tertiary care hospital were retrospectively identified from hospital administrative databases. Propensity score methods created best-matched pairs for the antibiotics. The matched pairs were used for adjusted comparisons on clinical response and allocation of hospital costs. Multiple regression analyses adjusting residual imbalance after matching were performed to confirm adjusted comparisons. Results Sixty matched pairs were created. Adjusted comparisons between vancomycin and linezolid showed similar clinical response rates (clinical cure: 30.0% versus 31.7%, respectively; P=0.847; treatment failure: 55.0% versus 45.0%, respectively; P=0.289) but a significantly lower in-hospital mortality rate for vancomycin (3.3% versus 18.3%, respectively; P=0.013). After further adjusting for the imbalanced variables between matched treatment groups, the risks of treatment failure associated with the two antibiotics were comparable (odds ratio: 1.139; P=0.308) and there was a nonsignificant trend of lower risk of in-hospital mortality associated with vancomycin (odds ratio: 0.186; P=0.055). The total hospital costs associated with vancomycin had a nonsignificant trend of being lower, likely because of its significantly lower acquisition costs (median: RMB 2,880 versus RMB 8,194; P<0.001; 1 RMB =0.16 USD). Conclusion In tertiary care hospitals in the People’s Republic of China, empirical treatment of patients with HAP with vancomycin had a comparable treatment failure rate but likely had a lower in-hospital mortality rate when compared with linezolid. Vancomycin also costs significantly less for drug acquisition than linezolid when treating HAP empirically. PMID:25378939

  14. An empirical study of scanner system parameters

    NASA Technical Reports Server (NTRS)

    Landgrebe, D.; Biehl, L.; Simmons, W.

    1976-01-01

    The selection of the current combination of parametric values (instantaneous field of view, number and location of spectral bands, signal-to-noise ratio, etc.) of a multispectral scanner is a complex problem due to the strong interrelationship these parameters have with one another. The study was done with the proposed scanner known as Thematic Mapper in mind. Since an adequate theoretical procedure for this problem has apparently not yet been devised, an empirical simulation approach was used with candidate parameter values selected by the heuristic means. The results obtained using a conventional maximum likelihood pixel classifier suggest that although the classification accuracy declines slightly as the IFOV is decreased this is more than made up by an improved mensuration accuracy. Further, the use of a classifier involving both spatial and spectral features shows a very substantial tendency to resist degradation as the signal-to-noise ratio is decreased. And finally, further evidence is provided of the importance of having at least one spectral band in each of the major available portions of the optical spectrum.

  15. Study of ESC [Empire State College] Graduates.

    ERIC Educational Resources Information Center

    Palola, Ernest G.; Ogden, Katharine

    This paper reports the results of a survey that examined the success or failure of Empire State College's first 29 graduates in obtaining admission to graduate school. Of the 13 applicants, 7 were accepted, 5 were waiting to hear, and 1 was rejected. Difficulties encountered by the applicants are discussed, as are the intentions of those not…

  16. Empirical derivation of an electronic clinically useful problem statement system.

    PubMed

    Brown, S H; Miller, R A; Camp, H N; Guise, D A; Walker, H K

    1999-07-20

    Problem lists are tools to improve patient management. In the medical record, they connect diagnoses to therapy, prognosis, and psychosocial issues. Computer-based problem lists enhance paper-based approaches by enabling cost-containment and quality assurance applications, but they require clinically expressive controlled vocabularies. Because existing controlled vocabularies do not represent problem statements at a clinically useful level, we derived a new canonical problem statement vocabulary through semi-automated analysis and distillation of provider-entered problem lists collected over 6 years from 74,696 patients. We combined automated and manual methods to condense 891,770 problem statements entered by 1961 care providers at Grady Memorial Hospital in Atlanta, Georgia, to 15,534 Canonical Clinical Problem Statement System (CCPSS) terms. The nature and frequency of problem statements were characterized, interrelations among them were enumerated, and a database capturing the epidemiology of problems was created. The authors identified 23,503 problem relations (co-occurrences, sign-symptom complexes, and differential diagnoses) and 22,690 modifier words that further categorized "canonical" problems. To assess completeness, CCPSS content was compared with that of the 1997 Unified Medical Language System Metathesaurus (containing terms from 44 clinical vocabularies). Unified Medical Language System terms expressed 25% of individual CCPSS terms exactly (71% of problems by frequency), 27% partially, and 48% poorly or not at all. Clinicians judged that CCPSS terms completely captured their clinical intent for 84% of 686 randomly selected free-text problem statements. The CCPSS represents clinical concepts at a level exceeding that of previous approaches. A similar national approach could create a standardized, useful, shared resource for clinical practice. PMID:10419428

  17. Clinical Feedback About Empirically Supported Treatments for Obsessive-Compulsive Disorder.

    PubMed

    Jacobson, Nicholas C; Newman, Michelle G; Goldfried, Marvin R

    2016-01-01

    Previous evidence for the treatment of obsessive-compulsive disorder (OCD) has been derived principally from randomized controlled trials. As such, evidence about the treatment of OCD has unilaterally flowed from researchers to clinicians. Despite often having decades of experience treating OCD, clinicians' feedback on their clinical observations in using these treatments has not been solicited. The current study contacted clinicians for their clinical observations on empirically supported treatments for OCD to identify commonly used cognitive-behavioral techniques and their limitations in their practices. One hundred eighty-one psychotherapists completed an online survey. The average participant practiced psychotherapy for 15 years, worked in private practice, held a doctorate, and treated an average of 25 clients with OCD in their lifetime. In regard to the most common techniques, behavioral strategies involving exposure to a feared outcome and prevention of a compulsive ritual were the most frequent group of interventions, followed by techniques that attempted to identify and challenge irrational thoughts. However, the majority of participants also reported incorporating mindfulness or acceptance-based methods. Based on therapists' reports, the most common barriers to the efficacy of cognitive-behavioral interventions included limited premorbid functioning, chaotic lifestyles, controlling and critical families, OCD symptom severity, OCD symptom chronicity, and comorbidities. This study provides insight into common practices and limitations in clinical practice to inform future clinically relevant treatment research. PMID:26763499

  18. An Empirical Study of Infrasonic Propagation

    SciTech Connect

    J. Paul Mutschlecner; Rodney W. Whitaker; Lawrence H. Auer

    1999-10-01

    Observations of atmospheric nuclear tests carried out at the Nevada Test Site from 1951 to 1958 provided data for an empirical investigation of how infrasonic signals are propagated to distances of about 250 km. Those observations and the analysis documented in this report involved signal amplitudes and average velocities and included three classes of signals: stratospheric, thermospheric, and tropospheric/surface. The authors' analysis showed that stratospheric winds have a dominant effect upon stratospheric signal amplitudes. The report outlines a method for normalizing stratospheric signal amplitudes for the effects of upper atmospheric winds and presents equations for predicting or normalizing amplitude and average velocity for the three types of signals.

  19. Dissociative absorption: An empirically unique, clinically relevant, dissociative factor.

    PubMed

    Soffer-Dudek, Nirit; Lassri, Dana; Soffer-Dudek, Nir; Shahar, Golan

    2015-11-01

    Research of dissociative absorption has raised two questions: (a) Is absorption a unique dissociative factor within a three-factor structure, or a part of one general dissociative factor? Even when three factors are found, the specificity of the absorption factor is questionable. (b) Is absorption implicated in psychopathology? Although commonly viewed as "non-clinical" dissociation, absorption was recently hypothesized to be specifically associated with obsessive-compulsive symptoms. To address these questions, we conducted exploratory and confirmatory factor analyses on 679 undergraduates. Analyses supported the three-factor model, and a "purified" absorption scale was extracted from the original inclusive absorption factor. The purified scale predicted several psychopathology scales. As hypothesized, absorption was a stronger predictor of obsessive-compulsive symptoms than of general psychopathology. In addition, absorption was the only dissociative scale that longitudinally predicted obsessive-compulsive symptoms. We conclude that absorption is a unique and clinically relevant dissociative tendency that is particularly meaningful to obsessive-compulsive symptoms. PMID:26241024

  20. An Empirical Investigation of Group Treatment for a Clinical Population of Adult Female Incest Survivors.

    ERIC Educational Resources Information Center

    Saxe, Brenda J.; Johnson, Susan M.

    1999-01-01

    Empirically assesses the effectiveness of a group treatment program on intrapersonal symptomatology and interpersonal difficulties in a clinical population of women with a history of incest. Results indicate that a time-limited group, which focuses on the original trauma, is effective in reducing intrapersonal symptomatology for women with a…

  1. Empirical Bayes for Group (DCM) Studies: A Reproducibility Study

    PubMed Central

    Litvak, Vladimir; Garrido, Marta; Zeidman, Peter; Friston, Karl

    2015-01-01

    This technical note addresses some key reproducibility issues in the dynamic causal modelling of group studies of event related potentials. Specifically, we address the reproducibility of Bayesian model comparison (and inferences about model parameters) from three important perspectives namely: (i) reproducibility with independent data (obtained by averaging over odd and even trials); (ii) reproducibility over formally distinct models (namely, classic ERP and canonical microcircuit or CMC models); and (iii) reproducibility over inversion schemes (inversion of the grand average and estimation of group effects using empirical Bayes). Our hope was to illustrate the degree of reproducibility one can expect from DCM when analysing different data, under different models with different analyses. PMID:26733846

  2. Empirical Bayes for Group (DCM) Studies: A Reproducibility Study.

    PubMed

    Litvak, Vladimir; Garrido, Marta; Zeidman, Peter; Friston, Karl

    2015-01-01

    This technical note addresses some key reproducibility issues in the dynamic causal modelling of group studies of event related potentials. Specifically, we address the reproducibility of Bayesian model comparison (and inferences about model parameters) from three important perspectives namely: (i) reproducibility with independent data (obtained by averaging over odd and even trials); (ii) reproducibility over formally distinct models (namely, classic ERP and canonical microcircuit or CMC models); and (iii) reproducibility over inversion schemes (inversion of the grand average and estimation of group effects using empirical Bayes). Our hope was to illustrate the degree of reproducibility one can expect from DCM when analysing different data, under different models with different analyses. PMID:26733846

  3. A review of empirical studies of verbal behavior

    PubMed Central

    Oah, She-zeen; Dickinson, Alyce M.

    1989-01-01

    This paper reviews empirical research which has been directly influenced by Skinner's Verbal Behavior. Despite the importance of this subject matter, the book has generated relatively little empirical research. Most studies have focused on Skinner's mand and tact relations while research focused on the other elementary verbal operants has been limited. However, the results of empirical research that exist support Skinner's analysis of the distinction between elementary verbal operants and his distinction between the speaker's and listener's repertoires. Further, research suggests that language training programs may not be successful if they do not provide explicit training of each elementary verbal operant and independent training of speaker's and listener's repertoires. PMID:22477586

  4. Empirical studies of regulatory restructuring and incentives

    NASA Astrophysics Data System (ADS)

    Knittel, Christopher Roland

    This dissertation examines the actions of firms when faced with regulatory restructuring. Chapter I examines the equilibrium pricing behavior of local exchange telephone companies under a variety of market structures. In particular, the pricing behavior of three services are analyzed: residential local service, business local service, and intraLATA toll service. Beginning in 1984, a variety of market structure changes have taken place in the local telecommunications industry. I analyze differences in the method of price-setting regulation and the restrictions on entry. Specifically, the relative pricing behavior under rate of return and price cap regulation is analyzed, as well as the impact of entry in the local exchange and intraLATA toll service markets. In doing so, I estimate an empirical model that accounts for the stickiness of rates in regulated industries that is based on firm and regulator decision processes in the presence of adjustment costs. I find that, faced with competitive pressures that reduce rates in one service, incumbent firm rates increase in other services, thereby reducing the benefits from competition. In addition, the findings suggest that price cap regulation leads to higher rates relative to rate-of-return regulation. Chapter 2 analyzes the pricing and investment behavior of electricity firms. Electricity and natural gas markets have traditionally been serviced by one of two market structures. In some markets, electricity and natural gas are sold by a dual-product regulated monopolist, while in other markets, electricity and natural gas are sold by separate single-product regulated monopolies. This paper analyzes the relative pricing and investment decisions of electricity firms operating in the two market structures. The unique relationship between these two products imply that the relative incentives of single and dual-product firms are likely to differ. Namely electricity and natural gas are substitutes in consumption while natural

  5. Empirical study on human acupuncture point network

    NASA Astrophysics Data System (ADS)

    Li, Jian; Shen, Dan; Chang, Hui; He, Da-Ren

    2007-03-01

    Chinese medical theory is ancient and profound, however is confined by qualitative and faint understanding. The effect of Chinese acupuncture in clinical practice is unique and effective, and the human acupuncture points play a mysterious and special role, however there is no modern scientific understanding on human acupuncture points until today. For this reason, we attend to use complex network theory, one of the frontiers in the statistical physics, for describing the human acupuncture points and their connections. In the network nodes are defined as the acupuncture points, two nodes are connected by an edge when they are used for a medical treatment of a common disease. A disease is defined as an act. Some statistical properties have been obtained. The results certify that the degree distribution, act degree distribution, and the dependence of the clustering coefficient on both of them obey SPL distribution function, which show a function interpolating between a power law and an exponential decay. The results may be helpful for understanding Chinese medical theory.

  6. How should clinical psychologists approach complementary and alternative medicine? Empirical, epistemological, and ethical considerations.

    PubMed

    Hughes, Brian M

    2008-04-01

    As complementary and alternative medicine (CAM) practices are often recommended for mental health problems, many clients in clinical psychology will be in receipt of such treatments from other practitioners. Some psychologists have argued that CAM and psychology are natural bedfellows, given their sharing of philosophies (e.g., holism), professional orientations (e.g., person-centeredness), and theoretical positions (e.g., mind-body connectionism). It has specifically been argued that the practices of CAM could productively be appropriated, or at least promoted, by clinical psychologists. However, other commentators have criticized CAM for comprising therapies that, by definition, are both intrinsically unscientific and lacking in empirical evidence. This article examines the current standing of CAM from empirical, epistemological, and ethical perspectives. CAM treatments are found to be based on heterogeneous epistemologies and to suffer from poor records in empirical efficacy research. Attention is given to possible psychological explanations for CAM's popularity in the face of poor evidence for efficacy. It is argued that, given the likely incompatibility of CAM with clinical psychology's positivist scientific ethos, CAM practices should not be integrated into clinical psychology at this time. PMID:17996344

  7. An Empirical Study about China: Gender Equity in Science Education.

    ERIC Educational Resources Information Center

    Wang, Jianjun; Staver, John R.

    A data base representing a random sample of more than 10,000 grade 9 students in an SISS (Second IEA Science Study) Extended Study (SES), a key project supported by the China State Commission of Education in the late 1980s, was employed in this study to investigate gender equity in student science achievement in China. This empirical data analysis…

  8. Online Learner's "Flow" Experience: An Empirical Study

    ERIC Educational Resources Information Center

    Shin, Namin

    2006-01-01

    This study is concerned with online learners' "low" experiences. On the basis of Csikszentmihalyi's theory of flow, flow was conceptualised as a complex, multimentional, reflective construct composing of "enjoyment", "telepresence", "focused attention", "engagement" and "time distortion" on the part of learners. A flow model was put forward with…

  9. Instruction for Web Searching: An Empirical Study.

    ERIC Educational Resources Information Center

    Colaric, Susan M.

    2003-01-01

    Discussion of problems that users have with Web searching focuses on a study of undergraduates that investigated three instructional methods (instruction by example, conceptual models without illustrations, and conceptual models with illustrations) to determine differences in knowledge acquisition related to three types of knowledge (declarative,…

  10. Attachment-based family therapy for depressed and suicidal adolescents: theory, clinical model and empirical support.

    PubMed

    Ewing, E Stephanie Krauthamer; Diamond, Guy; Levy, Suzanne

    2015-01-01

    Attachment-Based Family Therapy (ABFT) is a manualized family-based intervention designed for working with depressed adolescents, including those at risk for suicide, and their families. It is an empirically informed and supported treatment. ABFT has its theoretical underpinnings in attachment theory and clinical roots in structural family therapy and emotion focused therapies. ABFT relies on a transactional model that aims to transform the quality of adolescent-parent attachment, as a means of providing the adolescent with a more secure relationship that can support them during challenging times generally, and the crises related to suicidal thinking and behavior, specifically. This article reviews: (1) the theoretical foundations of ABFT (attachment theory, models of emotional development); (2) the ABFT clinical model, including training and supervision factors; and (3) empirical support. PMID:25778674

  11. Dynamics of crowd disasters: An empirical study

    NASA Astrophysics Data System (ADS)

    Helbing, Dirk; Johansson, Anders; Al-Abideen, Habib Zein

    2007-04-01

    Many observations of the dynamics of pedestrian crowds, including various self-organization phenomena, have been successfully described by simple many-particle models. For ethical reasons, however, there is a serious lack of experimental data regarding crowd panic. Therefore, we have analyzed video recordings of the crowd disaster in Mina/Makkah during the Hajj in 1426H on 12 January 2006. They reveal two subsequent, sudden transitions from laminar to stop-and-go and “turbulent” flows, which question many previous simulation models. While the transition from laminar to stop-and-go flows supports a recent model of bottleneck flows [D. Helbing , Phys. Rev. Lett. 97, 168001 (2006)], the subsequent transition to turbulent flow is not yet well understood. It is responsible for sudden eruptions of pressure release comparable to earthquakes, which cause sudden displacements and the falling and trampling of people. The insights of this study into the reasons for critical crowd conditions are important for the organization of safer mass events. In particular, they allow one to understand where and when crowd accidents tend to occur. They have also led to organizational changes, which have ensured a safe Hajj in 1427H.

  12. Shared Epistemic Agency: An Empirical Study of an Emergent Construct

    ERIC Educational Resources Information Center

    Damsa, Crina I.; Kirschner, Paul A.; Andriessen, Jerry E. B.; Erkens, Gijsbert; Sins, Patrick H. M.

    2010-01-01

    This article reports on a qualitative study of the construct of shared epistemic agency, investigated in the context of collaborative instructional design activities of university students. The aim of the study is to shed light on the notion of shared epistemic agency and to create empirical grounding for its theoretical description. The current…

  13. Visual Design Principles: An Empirical Study of Design Lore

    ERIC Educational Resources Information Center

    Kimball, Miles A.

    2013-01-01

    Many books, designers, and design educators talk about visual design principles such as balance, contrast, and alignment, but with little consistency. This study uses empirical methods to explore the lore surrounding design principles. The study took the form of two stages: a quantitative literature review to determine what design principles are…

  14. Research on Mathematical Thinking of Young Children: Six Empirical Studies.

    ERIC Educational Resources Information Center

    Steffe, Leslie P., Ed.

    This volume includes reports of six studies of the thought processes of children aged four through eight. In the first paper Steffe and Smock outline a model for learning and teaching mathematics. Six reports on empirical studies are then presented in five areas of mathematics learning: (1) equivalence and order relations; (2) classification and…

  15. Social amplification of risk: An empirical study

    SciTech Connect

    Burns, W.; Slovic, P. ) Kasperson, R.; Kasperson, J.; Renn, O.; Emani, S. )

    1990-09-01

    The social amplification of risk is a theoretical framework that addresses an important deficiency of formal risk assessment methods and procedures. Typically assessments of risk from technological mishaps have been based upon the expected number of people who could be killed or injured or the amount of property that might be damaged. The diverse and consequential impacts that followed in the aftermath of the Three Mile Island accident make it clear that risk assessments that exclude the role of public perceptions of risk will greatly underestimate the potential costs of certain types of hazards. The accident at Three Mile Island produced no direct fatalities and few, if any, expected deaths due to cancer, yet few other accidents in history have had such costly societal impacts. The experience of amplified impacts argues for the development of a broadened theoretical and methodological perspective capable of integrating technical assessment of risk with public perceptions. This report presents the results to date in an ongoing research effort to better understand the complex processes by which adverse events produce impacts. In particular this research attempts to construct a framework that can account for those events that have produced, or are capable of producing, greater societal impacts than would be forecast by traditional risk assessment methods. This study demonstrates that the social amplification of risk involves interactions between sophisticated technological hazards, public and private institutions, and subtle individual and public perceptions and behaviors. These factors, and the variables underlying the intricate processes of social amplification that occur in modern society, are not fully defined and clarified in this report. 19 refs., 9 figs., 10 tabs.

  16. The status of hypnosis as an empirically validated clinical intervention: a preamble to the special issue.

    PubMed

    Nash, M R

    2000-04-01

    In his introductory remarks to this Journal's special issue on the status of hypnosis as an empirically supported clinical intervention, the editor briefly describes the dawn of clinical hypnosis research, the logic of the natural science model, the importance of an inspired but tough-minded clinical science, and the auspicious confluence of practice and research purpose in this enterprise. The progenitor of this effort was indeed the Report of the Royal Commission coauthored by Benjamin Franklin and Antoine Lavoisier, among others, more than 215 years ago--a report noted as one of the most important documents in the history of human reason. The ethos and logic of this special issue is grounded on the legacy of that document. Eschewing the conflicting mental health agendas of managed-care, government, patient rights, and professional guild interests, this special issue seeks to present a frank, evenhanded, informed, and dispassionate assessment of what science knows and does not know about clinical hypnosis. PMID:10769979

  17. An empirical and model study on automobile market in Taiwan

    NASA Astrophysics Data System (ADS)

    Tang, Ji-Ying; Qiu, Rong; Zhou, Yueping; He, Da-Ren

    2006-03-01

    We have done an empirical investigation on automobile market in Taiwan including the development of the possession rate of the companies in the market from 1979 to 2003, the development of the largest possession rate, and so on. A dynamic model for describing the competition between the companies is suggested based on the empirical study. In the model each company is given a long-term competition factor (such as technology, capital and scale) and a short-term competition factor (such as management, service and advertisement). Then the companies play games in order to obtain more possession rate in the market under certain rules. Numerical simulation based on the model display a competition developing process, which qualitatively and quantitatively agree with our empirical investigation results.

  18. Principals' Performance Assessment: Empirical Evidence from an Israeli Case Study

    ERIC Educational Resources Information Center

    Gaziel, Haim

    2008-01-01

    Despite the current interest in many countries in assessing the principal's performance, stemming from the greater attention to educational reform and accountability, the empirical study of principal's appraisal has been slow to develop. This article was designed to fill partially this gap. Data was collected by semi-structured interviews of eight…

  19. An Empirical Study of Students on Academic Probation

    ERIC Educational Resources Information Center

    James, Cindy L.; Graham, Sarah

    2010-01-01

    A substantial number of university students are placed on academic probation each year, many of whom never succeed in academia. Hence, it is critical to identify who these students are, why they end up on academic probation, and most importantly how best to intervene. To determine this, an empirical study of students on academic probation for the…

  20. Educational Inequality and Income Inequality: An Empirical Study on China

    ERIC Educational Resources Information Center

    Yang, Jun; Huang, Xiao; Li, Xiaoyu

    2009-01-01

    Based on the endogenous growth theory, this paper uses the Gini coefficient to measure educational inequality and studies the empirical relationship between educational inequality and income inequality through a simultaneous equation model. The results show that: (1) Income inequality leads to educational inequality while the reduction of…

  1. Continued Use of a Chinese Online Portal: An Empirical Study

    ERIC Educational Resources Information Center

    Shih, Hung-Pin

    2008-01-01

    The evolution of the internet has made online portals a popular means of surfing the internet. In internet commerce, understanding the post-adoption behaviour of users of online portals can help enterprises to attract new users and retain existing customers. For predicting continued use intentions, this empirical study focused on applying and…

  2. Organisational Learning and Performance--An Empirical Study

    ERIC Educational Resources Information Center

    Jyothibabu, C.; Pradhan, Bibhuti Bhusan; Farooq, Ayesha

    2011-01-01

    This paper explores the important question "how the learning entities--individual, group or organisation--are affecting organisational performance". The answer is important for promoting learning and improving performance. This empirical study in the leading power utility in India found that there is a positive relation between individual- and…

  3. The Causes of Non-Attendance: An Empirical Study

    ERIC Educational Resources Information Center

    Reid, Ken

    2008-01-01

    This paper presents new evidence obtained from an empirical study which used three distinct groups of professionals engaged in the attempt to "brainstorm" reasons for pupils' non-attendance. The evidence suggests that the "causes" of pupils' non-attendance can be sub-divided into three main fields: pupils who dislike coming to school; those who…

  4. Reexamining competitive priorities: Empirical study in service sector

    NASA Astrophysics Data System (ADS)

    Idris, Fazli; Mohammad, Jihad

    2015-02-01

    The general objective of this study is to validate the multi-level concept of competitive priorities using reflective-formative model at a higher order for service industries. An empirical study of 228 firms from 9 different service industries is conducted to answer the objective of this study. Partial least square analysis with SmartPLS 2.0 was used to perform the analysis. Finding revealed six priorities: cost, flexibility, delivery, quality talent management, quality tangibility, and innovativeness. It emerges that quality are expanded into two types; one is related to managing talent for process improvement and the second one is the physical appearance and tangibility of the service quality. This study has confirmed competitive priorities as formative second-order hierarchical latent construct by using rigorous empirical evidence. Implications, limitation and suggestion for future research are accordingly discussed in this paper.

  5. Mission Operations Planning with Preferences: An Empirical Study

    NASA Technical Reports Server (NTRS)

    Bresina, John L.; Khatib, Lina; McGann, Conor

    2006-01-01

    This paper presents an empirical study of some nonexhaustive approaches to optimizing preferences within the context of constraint-based, mixed-initiative planning for mission operations. This work is motivated by the experience of deploying and operating the MAPGEN (Mixed-initiative Activity Plan GENerator) system for the Mars Exploration Rover Mission. Responsiveness to the user is one of the important requirements for MAPGEN, hence, the additional computation time needed to optimize preferences must be kept within reasonabble bounds. This was the primary motivation for studying non-exhaustive optimization approaches. The specific goals of rhe empirical study are to assess the impact on solution quality of two greedy heuristics used in MAPGEN and to assess the improvement gained by applying a linear programming optimization technique to the final solution.

  6. Chaotic Visual Cryptosystem Using Empirical Mode Decomposition Algorithm for Clinical EEG Signals.

    PubMed

    Lin, Chin-Feng

    2016-03-01

    This paper, proposes a chaotic visual cryptosystem using an empirical mode decomposition (EMD) algorithm for clinical electroencephalography (EEG) signals. The basic design concept is to integrate two-dimensional (2D) chaos-based encryption scramblers, the EMD algorithm, and a 2D block interleaver method to achieve a robust and unpredictable visual encryption mechanism. Energy-intrinsic mode function (IMF) distribution features of the clinical EEG signal are developed for chaotic encryption parameters. The maximum and second maximum energy ratios of the IMFs of a clinical EEG signal to its refereed total energy are used for the starting points of chaotic logistic map types of encrypted chaotic signals in the x and y vectors, respectively. The minimum and second minimum energy ratios of the IMFs of a clinical EEG signal to its refereed total energy are used for the security level parameters of chaotic logistic map types of encrypted chaotic signals in the x and y vectors, respectively. Three EEG database, and seventeen clinical EEG signals were tested, and the average r and mse values are 0.0201 and 4.2626 × 10(-29), respectively, for the original and chaotically-encrypted through EMD clinical EEG signals. The chaotically-encrypted signal cannot be recovered if there is an error in the input parameters, for example, an initial point error of 0.000001 %. The encryption effects of the proposed chaotic EMD visual encryption mechanism are excellent. PMID:26645316

  7. Moving Clinical Deliberations on Administrative Discharge in Drug Addiction Treatment Beyond Moral Rhetoric to Empirical Ethics.

    PubMed

    Williams, Izaak L

    2016-01-01

    Patients' admission to modern substance use disorder treatment comes with the attendant risk of being discharged from treatment-a widespread practice. This article describes the three mainstream theories of addiction that operate as a reference point for clinicians in reasoning about a decision to discharge a patient from treatment. The extant literature is reviewed to highlight the pathways that patients follow after administrative discharge. Little scientific research has been done to investigate claims and hypotheses about the therapeutic function of AD, which points to the need for empirical ethics to inform clinical addictions practice. PMID:27045311

  8. An empirical evaluation of multidimensional clinical outcome in chronic low back pain patients.

    PubMed

    Klapow, J C; Slater, M A; Patterson, T L; Doctor, J N; Atkinson, J H; Garfin, S R

    1993-10-01

    Individuals with persisting pain often present a constellation of symptoms that includes pain, health-related impairment and dysphoric mood. It is now widely accepted that comprehensive assessment must address each of these dimensions. Despite recognition of the value of multidimensional assessment, no empirical efforts have validated the construct of a multidimensional clinical outcome presentation based on the dimensions of pain, impairment and dysphoric mood. We employed cluster analytic procedures on standard measures of pain, impairment and depression in chronic low back pain (CLBP) patients (n = 96) attending a general orthopedic clinic in order to empirically characterize multidimensional clinical outcomes. Results indicated that 3 groups could be identified reliably: (1) 'Chronic Pain Syndrome' (n = 25; high levels of pain, impairment and depression), (2) 'Positive Adaptation to Pain' (n = 24; high levels of pain with low levels of impairment and depression) and (3) 'Good Pain Control' (n = 47; low levels of pain, impairment and depression). The reliability of this cluster solution was supported by several tests of internal consistency. Discriminability of the clusters was examined across both the outcome measures themselves and several additional independent variables. The cluster solution was then cross-validated in an independent sample of pain clinic CLBP patients (n = 180) to test its generalizability. Finally the stability of the cluster dimensions over time was tested by re-assessing 36 CLBP patients 6 months after they initially were characterized into 1 of the 3 outcome groups on the same measures. MANOVA results indicated that the outcome groups were differentiated statistically across assessments. The multiple outcome measures did not change significantly across time, nor did the outcome groups change differentially across time on these measures. We conclude that the outcome dimensions of pain, impairment and depression are relatively stable

  9. Are Clinical Studies for You?

    MedlinePlus

    ... Page > Participate in Clinical Studies If you are thinking about participating in a Clinical Study at NIH, ... medical care and activities of daily living. In thinking about the risks of research, it is helpful ...

  10. Empirical studies of design software: Implications for software engineering environments

    NASA Technical Reports Server (NTRS)

    Krasner, Herb

    1988-01-01

    The empirical studies team of MCC's Design Process Group conducted three studies in 1986-87 in order to gather data on professionals designing software systems in a range of situations. The first study (the Lift Experiment) used thinking aloud protocols in a controlled laboratory setting to study the cognitive processes of individual designers. The second study (the Object Server Project) involved the observation, videotaping, and data collection of a design team of a medium-sized development project over several months in order to study team dynamics. The third study (the Field Study) involved interviews with the personnel from 19 large development projects in the MCC shareholders in order to study how the process of design is affected by organizationl and project behavior. The focus of this report will be on key observations of design process (at several levels) and their implications for the design of environments.

  11. Learn about Clinical Studies

    MedlinePlus

    ... in the care of future patients by providing information about the benefits and risks of therapeutic, preventative, or diagnostic products or interventions. Clinical trials provide the basis for the development and marketing of new drugs, biological products, and medical devices. ...

  12. Clinical Studies with Epothilones

    NASA Astrophysics Data System (ADS)

    Altmann, Karl-Heinz

    As indicated in previous chapters, epothilone research so far has delivered seven new chemical entities that have been advanced to clinical trials in humans (Fig. 1). However, the amount of clinical data publicly available at this time strongly varies between individual compounds, depending on their development stage, but also on the general publication policy of the developing company. The compound that has been most comprehensively characterized in the clinical literature is ixabepilone (BMS-247550), for which trial results have been described in a number of articles in peer-reviewed journals and which has been granted FDA approval for two clinical indications on Oct. 16, 2007. For all other compounds, most of the information on clinical trials is available only in abstract form. In all these cases it remains uncertain, whether the content of these abstracts fully reflects the content of the subsequent (poster or oral) presentations at the corresponding meeting; in fact, it seems likely that additional data will have been included in the actual meeting presentations that may not have been available at the time of abstract submission. As this is unknown to the author, such additional information cannot be considered in this chapter, which is solely based on information documented in accessible abstracts or journal publications. It should also be kept in mind that the interpretation of data from ongoing clinical trials or forward looking statements based on data from completed trials are always preliminary in character.

  13. Bayesian model reduction and empirical Bayes for group (DCM) studies.

    PubMed

    Friston, Karl J; Litvak, Vladimir; Oswal, Ashwini; Razi, Adeel; Stephan, Klaas E; van Wijk, Bernadette C M; Ziegler, Gabriel; Zeidman, Peter

    2016-03-01

    This technical note describes some Bayesian procedures for the analysis of group studies that use nonlinear models at the first (within-subject) level - e.g., dynamic causal models - and linear models at subsequent (between-subject) levels. Its focus is on using Bayesian model reduction to finesse the inversion of multiple models of a single dataset or a single (hierarchical or empirical Bayes) model of multiple datasets. These applications of Bayesian model reduction allow one to consider parametric random effects and make inferences about group effects very efficiently (in a few seconds). We provide the relatively straightforward theoretical background to these procedures and illustrate their application using a worked example. This example uses a simulated mismatch negativity study of schizophrenia. We illustrate the robustness of Bayesian model reduction to violations of the (commonly used) Laplace assumption in dynamic causal modelling and show how its recursive application can facilitate both classical and Bayesian inference about group differences. Finally, we consider the application of these empirical Bayesian procedures to classification and prediction. PMID:26569570

  14. Bayesian model reduction and empirical Bayes for group (DCM) studies

    PubMed Central

    Friston, Karl J.; Litvak, Vladimir; Oswal, Ashwini; Razi, Adeel; Stephan, Klaas E.; van Wijk, Bernadette C.M.; Ziegler, Gabriel; Zeidman, Peter

    2016-01-01

    This technical note describes some Bayesian procedures for the analysis of group studies that use nonlinear models at the first (within-subject) level – e.g., dynamic causal models – and linear models at subsequent (between-subject) levels. Its focus is on using Bayesian model reduction to finesse the inversion of multiple models of a single dataset or a single (hierarchical or empirical Bayes) model of multiple datasets. These applications of Bayesian model reduction allow one to consider parametric random effects and make inferences about group effects very efficiently (in a few seconds). We provide the relatively straightforward theoretical background to these procedures and illustrate their application using a worked example. This example uses a simulated mismatch negativity study of schizophrenia. We illustrate the robustness of Bayesian model reduction to violations of the (commonly used) Laplace assumption in dynamic causal modelling and show how its recursive application can facilitate both classical and Bayesian inference about group differences. Finally, we consider the application of these empirical Bayesian procedures to classification and prediction. PMID:26569570

  15. Empirical Bayes MCMC Estimation for Modeling Treatment Processes, Mechanisms of Change, and Clinical Outcomes in Small Samples

    PubMed Central

    Ozechowski, Timothy J.

    2015-01-01

    Objective The current analysis demonstrates of the use of empirical Bayes estimation methods with data-derived prior parameters for studying clinically intricate process-mechanism-outcome linkages using structural equation modeling (SEM) with small samples. Method The data were obtained from a small subsample of 23 families receiving Functional Family Therapy (FFT) for adolescent substance abuse during a completed randomized clinical trial. Two or three video recorded FFT sessions were randomly selected for each family. The middle 20-minute portion of each session was observed and coded. A SEM was specified examining the influence of a select set of observed therapist behaviors on pre- to post-treatment change in mother-reports of family functioning and, in turn, pre- to post-treatment change in adolescent reports of adolescent marijuana use and delinquent behavior. The SEM was implemented using empirical Bayes estimation with data-derived maximum likelihood (ML) prior parameters and Markov Chain Monte Carlo (MCMC) estimation of the joint posterior distribution. Results The EB SEM results indicated that a relatively high proportion of individually focused general interventions (i.e., seek information, acknowledge) as well as relationally focused meaning change interventions by therapists during sessions of FFT were predictive of pre- to post-treatment increases in levels of family functioning as reported by mothers in families of substance abusing adolescents. In turn, increases in mother-reported family functioning were predictive of reductions in levels of adolescent-reported delinquent behavior. Conclusions EB MCMC methods produced more stable results than ML, especially regarding the variances on the change factors in the SEM. EB MCMC estimation is a viable alternative to ML estimation of SEMs in clinical research with prohibitively small samples. PMID:24512127

  16. Environmental performance indicators: an empirical study of Canadian manufacturing firms.

    PubMed

    Henri, Jean-François; Journeault, Marc

    2008-04-01

    The aim of this exploratory study is to examine the importance of measurement and use of environmental performance indicators (EPIs) within manufacturing firms. Two research questions are investigated: (i) To what extent are firm characteristics associated with the importance of measurement of various categories of EPIs? (ii) To what extent are firm characteristics associated with global and specific uses of EPIs? More specifically, this paper examines four uses of EPIs (i.e. to monitor compliance, to motivate continuous improvement, to support decision making, and to provide data for external reporting) as well as four characteristics of firms, namely environmental strategy, International Organization for Standardization (ISO) 14001 compliance, size, and ownership. This study contributes to the environmental management accounting literature by collecting and analyzing empirical evidence that provides a better understanding of the associations among firm characteristics and EPIs. PMID:17368921

  17. Tomography by iterative convolution - Empirical study and application to interferometry

    NASA Technical Reports Server (NTRS)

    Vest, C. M.; Prikryl, I.

    1984-01-01

    An algorithm for computer tomography has been developed that is applicable to reconstruction from data having incomplete projections because an opaque object blocks some of the probing radiation as it passes through the object field. The algorithm is based on iteration between the object domain and the projection (Radon transform) domain. Reconstructions are computed during each iteration by the well-known convolution method. Although it is demonstrated that this algorithm does not converge, an empirically justified criterion for terminating the iteration when the most accurate estimate has been computed is presented. The algorithm has been studied by using it to reconstruct several different object fields with several different opaque regions. It also has been used to reconstruct aerodynamic density fields from interferometric data recorded in wind tunnel tests.

  18. Information Assurance in Saudi Organizations - An Empirical Study

    NASA Astrophysics Data System (ADS)

    Nabi, Syed Irfan; Mirza, Abdulrahman A.; Alghathbar, Khaled

    This paper presents selective results of a survey conducted to find out the much needed insight into the status of information security in Saudi Arabian organizations. The purpose of this research is to give the state of information assurance in the Kingdom and to better understand the prevalent ground realities. The survey covered technical aspects of information security, risk management and information assurance management. The results provide deep insights in to the existing level of information assurance in various sectors that can be helpful in better understanding the intricate details of the prevalent information security in the Kingdom. Also, the results can be very useful for information assurance policy makers in the government as well as private sector organizations. There are few empirical studies on information assurance governance available in literature, especially about the Middle East and Saudi Arabia, therefore, the results are invaluable for information security researchers in improving the understanding of information assurance in this region and the Kingdom.

  19. Empirical study of the tails of mutual fund size

    NASA Astrophysics Data System (ADS)

    Schwarzkopf, Yonathan; Farmer, J. Doyne

    2010-06-01

    The mutual fund industry manages about a quarter of the assets in the U.S. stock market and thus plays an important role in the U.S. economy. The question of how much control is concentrated in the hands of the largest players is best quantitatively discussed in terms of the tail behavior of the mutual fund size distribution. We study the distribution empirically and show that the tail is much better described by a log-normal than a power law, indicating less concentration than, for example, personal income. The results are highly statistically significant and are consistent across fifteen years. This contradicts a recent theory concerning the origin of the power law tails of the trading volume distribution. Based on the analysis in a companion paper, the log-normality is to be expected, and indicates that the distribution of mutual funds remains perpetually out of equilibrium.

  20. An Empirical Study of Student Willingness to Study Abroad

    ERIC Educational Resources Information Center

    Hackney, Kaylee; Boggs, David; Borozan, Anci

    2012-01-01

    Companies wish for universities to provide business students with international education and awareness. Short- and long-term study-abroad programs are an effective method by which this is accomplished, but relatively few American students study abroad. In response to these facts, this study develops hypotheses that predict student willingness to…

  1. Adult Attachment and Developmental Personality Styles: An Empirical Study

    ERIC Educational Resources Information Center

    Sherry, Alissa; Lyddon, William J.; Henson, Robin K.

    2007-01-01

    The current study was designed to test specific hypotheses associated with W. J. Lyddon and A. Sherry's (2001) attachment theory model of developmental personality styles. More specifically, 4 adult attachment dimensions were correlated with 10 personality scales on the Millon Clinical Multiaxial Inventory-III (T. Millon, R. Davis, & C. Millon,…

  2. Physician leadership styles and effectiveness: an empirical study.

    PubMed

    Xirasagar, Sudha; Samuels, Michael E; Stoskopf, Carleen H

    2005-12-01

    The authors study the association between physician leadership styles and leadership effectiveness. Executive directors of community health centers were surveyed (269 respondents; response rate = 40.9 percent) for their perceptions of the medical director's leadership behaviors and effectiveness, using an adapted Multifactor Leadership Questionnaire (43 items on a 0-4 point Likert-type scale), with additional questions on demographics and the center's clinical goals and achievements. The authors hypothesize that transformational leadership would be more positively associated with executive directors' ratings of effectiveness, satisfaction with the leader, and subordinate extra effort, as well as the center's clinical goal achievement, than transactional or laissez-faire leadership. Separate ordinary least squares regressions were used to model each of the effectiveness measures, and general linear model regression was used to model clinical goal achievement. Results support the hypothesis and suggest that physician leadership development using the transformational leadership model may result in improved health care quality and cost control. PMID:16330822

  3. First-Principles and Semi-Empirical Studies of Microclusters.

    NASA Astrophysics Data System (ADS)

    Chang, Audrey Young-Zee

    The structural, electronic and magnetic properties of clusters have been a subject of intense investigation in recent years, due to many advancements in theoretical and experimental techniques. Since the bonding of atoms in clusters is often different from in bulk, clusters may assume different shapes and structures as the size varies. They therefore provide a model for understanding the transition and structural formation of bulk materials. In this dissertation, two different approaches for pursuing cluster study are carried out: one is based on a realistic but semi-empirical method, the other is more of a first-principles type of calculation. In the first part, the implementation and application of a dynamics simulated annealing scheme, introduced by Car and Parrinello, to a semi-empirical tight-binding model for studying the silicon clusters is presented. In searching for the ground state structures, Langevin molecular dynamics is employed to allow relaxation of the nuclei. For small silicon clusters, Si_{n} (n <= 10), a preference of close-packed structure with binding energies depending on the size are found. Relatively stable structures are observed for clusters of size 4, 6 and 7 which are in accordance with the experimentally found "magic number". In the second part, the study of transition-metal chromium clusters via a first-principles, all-electron, linear combination of Gaussian orbitals method is presented. Transition -metal elements are characterized by having contracted valence d-orbitals containing up to ten electrons, which make them a highly correlated system. The many-electron effects attributed to interactions among these electrons are manifested rather dramatically through the observed magnetic ordering. In this study, the magnetic and structural properties of chromium clusters, (Cr_{n} n <= 9), are investigated based on density functional theory. In bulk, the bcc chromium crystal has a weak antiferromagnetic coupling due to Fermi surfaces

  4. Investigating Invariant Item Ordering in Personality and Clinical Scales: Some Empirical Findings and a Discussion

    ERIC Educational Resources Information Center

    Meijer, Rob R.; Egberink, Iris J. L.

    2012-01-01

    In recent studies, different methods were proposed to investigate invariant item ordering (IIO), but practical IIO research is an unexploited field in questionnaire construction and evaluation. In the present study, the authors explored the usefulness of different IIO methods to analyze personality scales and clinical scales. From the authors'…

  5. Communication and Organization in Software Development: An Empirical Study

    NASA Technical Reports Server (NTRS)

    Seaman, Carolyn B.; Basili, Victor R.

    1996-01-01

    The empirical study described in this paper addresses the issue of communication among members of a software development organization. The independent variables are various attributes of organizational structure. The dependent variable is the effort spent on sharing information which is required by the software development process in use. The research questions upon which the study is based ask whether or not these attributes of organizational structure have an effect on the amount of communication effort expended. In addition, there are a number of blocking variables which have been identified. These are used to account for factors other than organizational structure which may have an effect on communication effort. The study uses both quantitative and qualitative methods for data collection and analysis. These methods include participant observation, structured interviews, and graphical data presentation. The results of this study indicate that several attributes of organizational structure do affect communication effort, but not in a simple, straightforward way. In particular, the distances between communicators in the reporting structure of the organization, as well as in the physical layout of offices, affects how quickly they can share needed information, especially during meetings. These results provide a better understanding of how organizational structure helps or hinders communication in software development.

  6. Data envelopment analysis in service quality evaluation: an empirical study

    NASA Astrophysics Data System (ADS)

    Najafi, Seyedvahid; Saati, Saber; Tavana, Madjid

    2015-10-01

    Service quality is often conceptualized as the comparison between service expectations and the actual performance perceptions. It enhances customer satisfaction, decreases customer defection, and promotes customer loyalty. Substantial literature has examined the concept of service quality, its dimensions, and measurement methods. We introduce the perceived service quality index (PSQI) as a single measure for evaluating the multiple-item service quality construct based on the SERVQUAL model. A slack-based measure (SBM) of efficiency with constant inputs is used to calculate the PSQI. In addition, a non-linear programming model based on the SBM is proposed to delineate an improvement guideline and improve service quality. An empirical study is conducted to assess the applicability of the method proposed in this study. A large number of studies have used DEA as a benchmarking tool to measure service quality. These models do not propose a coherent performance evaluation construct and consequently fail to deliver improvement guidelines for improving service quality. The DEA models proposed in this study are designed to evaluate and improve service quality within a comprehensive framework and without any dependency on external data.

  7. Functional somatic symptoms and hypochondriasis. A survey of empirical studies.

    PubMed

    Kellner, R

    1985-08-01

    Empirical studies suggest the following main conclusions: functional somatic symptoms are extremely common; a large proportion appear to be caused by physiologic activity and tend to be aggravated by emotion. Hypochondriacal patients misunderstand the nature and significance of these symptoms and believe that they are evidence of serious disease. Hypochondriasis can be a part of another syndrome, usually an affective one, or it can be a primary disorder. The prevalence differs between cultures and social classes. Constitutional factors, disease in the family in childhood, and previous disease predispose to hypochondriasis. Various stressors can be precipitating events. Selective perception of symptoms, motivated by fear of disease, and subsequent increase in anxiety with more somatic symptoms appear to be links in the vicious cycle of the hypochondriacal reaction. Psychotherapy as well as psychotropic drugs are effective in the treatment of functional somatic symptoms. There are no adequate controlled studies of psychotherapy in hypochondriasis, and the recommended treatments are based on studies with similar disorders. The prognosis of treated hypochondriasis is good in a substantial proportion of patients. PMID:2861797

  8. Empirical study of crowd behavior during a real mass event

    NASA Astrophysics Data System (ADS)

    Zhang, X. L.; Weng, W. G.; Yuan, H. Y.

    2012-08-01

    The study of crowd behavior is essential for the safe organization of mass events. However, precise quantitative empirical data are insufficient due to the lack of mass event scenarios suitable for observation. In this paper, crowd behavior during a mass event in which many people go through a door and then pass a bridge is studied by a new method based on a flow field visualization algorithm widely used in fluid experiments. Two important movement phases, laminar flow on a bridge and stop-and-go waves in a bottleneck area, are investigated. The results show that the velocity profile on the bridge is similar to that of fully developed laminar flow in a pipe. Quantitative analysis of the stop-and-go wave in the bottleneck area shows that the dominant fluctuation frequencies are mainly below 0.1 Hz and the peak frequency is around 0.05 Hz the wave propagation speed is about - 0.69 m s-1. The absolute decrease in speed as the wave propagates is also indicated. By a combination of shock wave theory and a fundamental diagram, an analytical model of a shock wave in a crowd is established to theoretically investigate the stop-and-go wave, and the model can be used to explain the measurement results. This study provides a new method and fundamental data for understanding crowd behavior. The results are also expected to be useful for the design of crowd management strategies during mass events.

  9. Setting healthcare priorities in hospitals: a review of empirical studies.

    PubMed

    Barasa, Edwine W; Molyneux, Sassy; English, Mike; Cleary, Susan

    2015-04-01

    Priority setting research has focused on the macro (national) and micro (bedside) level, leaving the meso (institutional, hospital) level relatively neglected. This is surprising given the key role that hospitals play in the delivery of healthcare services and the large proportion of health systems resources that they absorb. To explore the factors that impact upon priority setting at the hospital level, we conducted a thematic review of empirical studies. A systematic search of PubMed, EBSCOHOST, Econlit databases and Google scholar was supplemented by a search of key websites and a manual search of relevant papers' reference lists. A total of 24 papers were identified from developed and developing countries. We applied a policy analysis framework to examine and synthesize the findings of the selected papers. Findings suggest that priority setting practice in hospitals was influenced by (1) contextual factors such as decision space, resource availability, financing arrangements, availability and use of information, organizational culture and leadership, (2) priority setting processes that depend on the type of priority setting activity, (3) content factors such as priority setting criteria and (4) actors, their interests and power relations. We observe that there is need for studies to examine these issues and the interplay between them in greater depth and propose a conceptual framework that might be useful in examining priority setting practices in hospitals. PMID:24604831

  10. Setting healthcare priorities in hospitals: a review of empirical studies

    PubMed Central

    Barasa, Edwine W; Molyneux, Sassy; English, Mike; Cleary, Susan

    2015-01-01

    Priority setting research has focused on the macro (national) and micro (bedside) level, leaving the meso (institutional, hospital) level relatively neglected. This is surprising given the key role that hospitals play in the delivery of healthcare services and the large proportion of health systems resources that they absorb. To explore the factors that impact upon priority setting at the hospital level, we conducted a thematic review of empirical studies. A systematic search of PubMed, EBSCOHOST, Econlit databases and Google scholar was supplemented by a search of key websites and a manual search of relevant papers’ reference lists. A total of 24 papers were identified from developed and developing countries. We applied a policy analysis framework to examine and synthesize the findings of the selected papers. Findings suggest that priority setting practice in hospitals was influenced by (1) contextual factors such as decision space, resource availability, financing arrangements, availability and use of information, organizational culture and leadership, (2) priority setting processes that depend on the type of priority setting activity, (3) content factors such as priority setting criteria and (4) actors, their interests and power relations. We observe that there is need for studies to examine these issues and the interplay between them in greater depth and propose a conceptual framework that might be useful in examining priority setting practices in hospitals. PMID:24604831

  11. An efficient empirical Bayes method for genomewide association studies.

    PubMed

    Wang, Q; Wei, J; Pan, Y; Xu, S

    2016-08-01

    Linear mixed model (LMM) is one of the most popular methods for genomewide association studies (GWAS). Numerous forms of LMM have been developed; however, there are two major issues in GWAS that have not been fully addressed before. The two issues are (i) the genomic background noise and (ii) low statistical power after Bonferroni correction. We proposed an empirical Bayes (EB) method by assigning each marker effect a normal prior distribution, resulting in shrinkage estimates of marker effects. We found that such a shrinkage approach can selectively shrink marker effects and reduce the noise level to zero for majority of non-associated markers. In the meantime, the EB method allows us to use an 'effective number of tests' to perform Bonferroni correction for multiple tests. Simulation studies for both human and pig data showed that EB method can significantly increase statistical power compared with the widely used exact GWAS methods, such as GEMMA and FaST-LMM-Select. Real data analyses in human breast cancer identified improved detection signals for markers previously known to be associated with breast cancer. We therefore believe that EB method is a valuable tool for identifying the genetic basis of complex traits. PMID:26582716

  12. Cultural Competency and Achieving Styles in Clinical Social Work: A Conceptual and Empirical Exploration.

    ERIC Educational Resources Information Center

    Lu, Yuhwa Eva; Lum, Doman; Chen, Sheying

    2001-01-01

    A study explored the relationship between linguistic/cultural differences and individual achieving styles among 900 clinical social workers, including Asian Americans, Latinos, American Indians, African Americans, Jewish Americans, and Whites. Findings are related to a model of cultural competency in which cross-cultural counselor-client…

  13. Olfactory enhanced multimedia applications: perspectives from an empirical study

    NASA Astrophysics Data System (ADS)

    Ademoye, Oluwakemi A.; Ghinea, Gheorghita

    2007-01-01

    The increasing demand for multi-modal systems and applications that are highly interactive and multi-sensory in nature has led to the introduction of new media and new user interface devices in multimedia computing. Computer generated smell, also known as olfactory data, is one of such media objects currently generating a lot of interest in the multimedia industry. We are currently focusing our attention on exploring user perception of computer generated smell when combined with other media to enrich their multimedia experience. In this paper, we present the results of an empirical study into users' perception of olfactory enhanced multimedia displays. Results showed that users generally enjoy an enhanced multimedia experience when augmented by olfactory stimuli, and that the presence of such stimuli increases the sense of relevance. Whilst there is a general positive bias towards olfactory enhanced multimedia applications, specific properties of smell such as diffusion and lingering mean that in practice specific attention needs to be given when a mix of smells is associated with visualised multimedia content; moreover, it was found that whilst smell was incorrectly identified in some instances, the presence of smell per se is generally enough to create a richer user multimedia experience.

  14. An empirical study of FORTRAN programs for parallelizing compilers

    NASA Technical Reports Server (NTRS)

    Shen, Zhiyu; Li, Zhiyuan; Yew, Pen-Chung

    1990-01-01

    Some results are reported from an empirical study of program characteristics that are important in parallelizing compiler writers, especially in the area of data dependence analysis and program transformations. The state of the art in data dependence analysis and some parallel execution techniques are examined. The major findings are included. Many subscripts contain symbolic terms with unknown values. A few methods of determining their values at compile time are evaluated. Array references with coupled subscripts appear quite frequently; these subscripts must be handled simultaneously in a dependence test, rather than being handled separately as in current test algorithms. Nonzero coefficients of loop indexes in most subscripts are found to be simple: they are either 1 or -1. This allows an exact real-valued test to be as accurate as an exact integer-valued test for one-dimensional or two-dimensional arrays. Dependencies with uncertain distance are found to be rather common, and one of the main reasons is the frequent appearance of symbolic terms with unknown values.

  15. An empirical study of Fortran programs for parallelizing compilers

    SciTech Connect

    Shen, Z. ); Li, Z. ); Yew, P.C. . Center for Supercomputing Research and Development)

    1990-07-01

    In this paper, the authors report some results from an empirical study of program characteristics that are important to parallelizing compiler writers, especially in the area of data dependence analysis and program transformations. The state of the art in data dependence analysis and some parallel execution techniques are also examined. The major findings include: many subscripts contain symbolic terms with unknown values. A few methods to determine their values at compile time are evaluated; array references with coupled subscripts appear quite frequently. These subscripts must be handled simultaneously in a dependence test, rather than being handled separately as in current test algorithms; nonzero coefficients of loop indexes in most subscripts are found to be simple: they are either 1 or -1. It allows an exact real-valued test to be as accurate as an exact integer-valued test for one-dimensional or two-dimensional arrays; dependences with uncertain distance are found to be rather common, and one of the main reasons is the frequent appearance of symbolic terms with unknown values.

  16. An Empirical Study of Structural Constraint Solving Techniques

    NASA Astrophysics Data System (ADS)

    Siddiqui, Junaid Haroon; Khurshid, Sarfraz

    Structural constraint solving allows finding object graphs that satisfy given constraints, thereby enabling software reliability tasks, such as systematic testing and error recovery. Since enumerating all possible object graphs is prohibitively expensive, researchers have proposed a number of techniques for reducing the number of potential object graphs to consider as candidate solutions. These techniques analyze the structural constraints to prune from search object graphs that cannot satisfy the constraints. Although, analytical and empirical evaluations of individual techniques have been done, comparative studies of different kinds of techniques are rare in the literature. We performed an experiment to evaluate the relative strengths and weaknesses of some key structural constraint solving techniques. The experiment considered four techniques using: a model checker, a SAT solver, a symbolic execution engine, and a specialized solver. It focussed on their relative abilities in expressing the constraints and formatting the output object graphs, and most importantly on their performance. Our results highlight the tradeoffs of different techniques and help choose a technique for practical use.

  17. Social Health Status in Iran: An Empirical Study

    PubMed Central

    AMINI RARANI, Mostafa; RAFIYE, Hassan; KHEDMATI MORASAE, Esmaeil

    2013-01-01

    Background: As social health is a condition-driven, dynamic and fluid concept, it seems necessary to construct and obtain a national and relevant concept of it for every society. Providing an empirical back up for Iran’s concept of social health was the aim of the present study. Methods: This study is an ecologic study in which available data for 30 provinces of Iran in 2007 were analyzed. In order to prove construct validity and obtain a social health index, an exploratory factor analysis was conducted on six indicators of population growth, willful murder, poverty, unemployment, insurance coverage and literacy. Results: Following the factor analysis, two factors of Diathesis (made up of high population growth, poverty, low insurance coverage and illiteracy) and Problem (made up of unemployment and willful murder) were extracted. The diathesis and problem explained 48.6 and 19.6% of social health variance respectively. From provinces, Sistan & Baluchistan had the highest rate of poverty and violence and the lowest rate of literacy and insurance coverage. In terms of social health index, Tehran, Semnan, Isfahan, Bushehr and Mazandaran had the highest ranks while Sistan and Baluchistan, Lurestan, Kohkiloyeh and Kermanshah occupied the lowest ones. Conclusion: There are some differences and similarities between Iranian concept of social health and that of other societies. However, a matter that makes our concept special and different is its attention to population. The increase in literacy rate and insurance coverage along with reduction of poverty, violence and unemployment rates can be the main intervention strategies to improve social health status in Iran. PMID:23515572

  18. Flood risk changes over centuries in Rome: an empirical study

    NASA Astrophysics Data System (ADS)

    Di Baldassarre, Giuliano; Saccà, Smeralda; Tito Aronica, Giuseppe; Grimaldi, Salvatore; Crisci, Massimiliano

    2015-04-01

    Over centuries, the development of the historical city of Rome -close to one of the largest Italian rivers, the Tiber- has been intertwined with the magnitude and frequency of flooding events. The ancient Rome mostly developed on the (seven) hills, while the Tiber's floodplain was mainly exploited for agricultural purposes. A few small communities did settle in the riparian areas of the Tiber, but they had a relatively peaceful relationships with the frequent occurrence of flooding events. Nowadays, numerous people live in modern districts in the Tiber's floodplain, unaware of their exposure to potentially catastrophic flooding. The main goal of this research is to explore the dynamics of changing flood risk over the centuries between these two extreme pictures of the ancient and contemporary Rome. To this end, we carried out a socio-hydrological study by exploiting long time series of physical (flooding, river morphology) and social (urbanization, population dynamics) processes together with information about human interactions with the environment (flood defense structures). This empirical analysis showed how human and physical systems have been co-evolving over time, while being abruptly altered by the occurrence of extreme events. For instance, a large flooding event occurred in 1870 and contributed to the constructions of levees, which in turn facilitated the development of new urban areas in the Tiber's floodplain, while changed the societal memory of floods as well as the communities' perception of risk. This research work was also used to test the hypotheses of recent-developed models conceptualizing the interplay between floods and societies and simulating the long-term behavior of coupled human-water systems. The outcomes of this test provided interesting insights about the dynamics of flood risk, which are expected to support a better anticipation of future changes.

  19. An Empirical Study on the Successful Implementation of Nursing Information System.

    PubMed

    Tsai, Hui-Hua; Chiou, Shwu-Fen; Wang, Tsi-Chi; Wu, Meng-Ping; Feng, Rung-Chuang

    2016-01-01

    This study investigated the major NIS implementation factors and their capability of predicting the effectiveness of NIS implementation by using the clinical information systems success model. The triangulation method was employed in this study. A total of 348 nurses were recruited from regional hospitals in two districts of Taipei through purposive sampling. Research data were collected through questionnaires and focus group interviews 3 and 6 months after an NIS was implemented at their hospital. The result show the explanatory power of use dependence, use satisfaction, and net benefits in predicting NIS effectiveness was approximately 64.5%-89.4%. The explanatory power of net benefits in predicting NIS effectiveness after 3 and 6 months exceeded 80%. The nurses reported that NIS implementation changed their workflow and positively influenced medication administration safety. This study empirically identified the critical factors that affect the successful implementation of NISs and reported the nurses' experience of NIS use. PMID:27332372

  20. [Empiric treatment of pyelonephritis].

    PubMed

    Iarovoĭ, S K; Shimanovskiĭ, N L; Kareva, E N

    2011-01-01

    The article analyses the most typical clinical situations in empirical treatment of pyelonephritis including situations with comorbid severe diseases: decompensated diabetes mellitus, chronic renal failure, HIV-infection. Choice of antibacterial medicines for empiric treatment of pyelonephritis is based on the results of the latest studies of antibioticoresistance of pyelonephritis pathogens as well as on specific features of pharmacokinetics and pharmacodynamics of antibacterial drugs. PMID:21815461

  1. Empirical Study of Formative Evaluation in Adult ESL Teaching

    ERIC Educational Resources Information Center

    Yi, Qin

    2012-01-01

    Formative Evaluation is a method of evaluating a program while the program activities are forming or happening. Formative evaluation focuses on the "process" during which problems are timely spotted, corrected and adjustments made so that an intended goal can be accomplished. Through a four-month empirical research work with students of…

  2. Empirically supported treatments for panic disorder with agoraphobia in a Spanish psychology clinic.

    PubMed

    Ballesteros, Francisco; Labrador, Francisco J

    2014-01-01

    The aim of this work is to study the sociodemographic and clinical characteristics of patients diagnosed with Panic Disorder with Agoraphobia (PD/Ag), as well as the characteristics of the treatment and its results and cost in a University Psychology Clinic. Fifty patients demanded psychological assistance for PD/Ag; 80% were women, with an average age of 29.22 years (SD = 9.03). Mean number of evaluation sessions was 3.26 (SD = 1.03), and of treatment sessions, 13.39 (SD = 9.237). Of the patients, 83.33% were discharged (that is, questionnaire scores were below the cut-off point indicated by the authors, and no PD/Ag was observed at readministration of the semistructured interview), 5.5% refused treatment, and 11% were dropouts. The average number of treatment sessions of patients who achieved therapeutic success was 15.13 (SD = 8.98). Effect sizes (d) greater than 1 were obtained in all the scales. Changes in all scales were significant (p < .05). The estimated cost of treatment for patients who achieved therapeutic success was 945.12€. The treatment results are at least similar to those of studies of efficacy and effectiveness for PD/Ag. The utility of generalizing treatments developed in research settings to a welfare clinic is discussed. PMID:26054491

  3. An empirical study of scanner system parameters. [for remote sensing

    NASA Technical Reports Server (NTRS)

    Landgrebe, D. A.; Biehl, L. L.; Simmons, W. R.

    1977-01-01

    Parametric values (instantaneous field of view, number and location of spectral bands, signal-to-noise ratio, etc.) of a multispectral scanner (thematic mapper) are assigned empirically. An empirical simulation approach was used with candidate parameter values selected by heuristic means. Results obtained using a conventional maximum likelihood pixel classifier suggest that although the classification accuracy declines slightly as the instantaneous field of view (IFOV) is decreased this is more than made up by an improved mensuration accuracy. Use of a classifier involving both spatial and spectral features helps resist degradation as the signal-to-noise ratio is decreased. The importance of having at least one spectral band in each of the major available portions of the optical spectrum is demonstrated.

  4. A clinical trial comparing physician prompting with an unprompted automated electronic checklist to reduce empirical antibiotic utilization

    PubMed Central

    Weiss, Curtis H.; DiBardino, David; Rho, Jason; Sung, Nina; Collander, Brett; Wunderink, Richard G.

    2013-01-01

    Objective To determine whether face-to-face prompting of critical care physicians reduces empirical antibiotic utilization compared to an unprompted electronic checklist embedded within the electronic health record (EHR). Design Random allocation design. Setting Medical intensive care unit (MICU) with high-intensity intensivist coverage at a tertiary care urban medical center. Patients Two hundred ninety-six critically ill patients treated with at least one day of empirical antibiotics. Interventions For one MICU team, face-to-face prompting of critical care physicians if they did not address empirical antibiotic utilization during a patient’s daily rounds. On a separate MICU team, attendings and fellows were trained once to complete an EHR-embedded checklist daily for each patient, including a question asking whether listed empirical antibiotics could be discontinued. Measurements and main results Prompting led to a more than 4-fold increase in discontinuing or narrowing of empirical antibiotics compared to use of the electronic checklist. Prompted group patients had a lower proportion of patient-days on which empirical antibiotics were administered compared to electronic checklist group patients (63.1% vs. 70.0%, P=0.002). Mean proportion of antibiotic-days on which empirical antibiotics were used was also lower in the prompted group, although not statistically significant (0.78 [0.27] vs. 0.83 [0.27], P=0.093). Each additional day of empirical antibiotics predicted higher risk-adjusted mortality (odds ratio 1.14, 95% CI 1.05–1.23). Risk-adjusted ICU length of stay and hospital mortality were not significantly different between the two groups. Conclusions Face-to-face prompting was superior to an unprompted EHR-based checklist at reducing empirical antibiotic utilization. Sustained culture change may have contributed to the electronic checklist having similar empirical antibiotic utilization to a prompted group in the same MICU two years prior. Future studies

  5. The Role of Light and Music in Gambling Behaviour: An Empirical Pilot Study

    ERIC Educational Resources Information Center

    Spenwyn, Jenny; Barrett, Doug J. K.; Griffiths, Mark D.

    2010-01-01

    Empirical research examining the situational characteristics of gambling and their effect on gambling behaviour is limited but growing. This experimental pilot investigation reports the first ever empirical study into the combined effects of both music and light on gambling behaviour. While playing an online version of roulette, 56 participants…

  6. Feature Evaluation for Building Facade Images - AN Empirical Study

    NASA Astrophysics Data System (ADS)

    Yang, M. Y.; Förstner, W.; Chai, D.

    2012-08-01

    The classification of building facade images is a challenging problem that receives a great deal of attention in the photogrammetry community. Image classification is critically dependent on the features. In this paper, we perform an empirical feature evaluation task for building facade images. Feature sets we choose are basic features, color features, histogram features, Peucker features, texture features, and SIFT features. We present an approach for region-wise labeling using an efficient randomized decision forest classifier and local features. We conduct our experiments with building facade image classification on the eTRIMS dataset, where our focus is the object classes building, car, door, pavement, road, sky, vegetation, and window.

  7. An empirical assessment of social structural and cultural change in clinical directorates.

    PubMed

    Braithwaite, Jeffrey

    2006-12-01

    The results of two observational studies of clinical directorates (CDs) are presented. The paper exposes fresh perspectives about the management of hospitals and CDs, and suggests that the most important axis on which hospital decision-making rests continues to be profession rather than the CD, even though CDs are designed at least in part to mitigate professional tribalism and bridge professional divides. In empiricising social structural and cultural theories it seems clear that changes to the prescribed organisational framework, which CDs represent, have had negligible effects on behaviour. This being the case, the paper questions the benefits alleged to have accrued from establishing CDs and calls for more effective, micro-behavioural change strategies than merely altering the structure. PMID:17214253

  8. Imaging skin pathologies with polarized light: Empirical and theoretical studies

    NASA Astrophysics Data System (ADS)

    Ramella-Roman, Jessica C.

    The use of polarized light imaging can facilitate the determination of skin cancer borders before a Mohs surgery procedure. Linearly polarized light that illuminates the skin is backscattered by superficial layers where cancer often arises and is randomized by the collagen fibers. The superficially backscattered light can be distinguished from the diffused reflected light using a detector analyzer that is sequentially oriented parallel and perpendicular to the source polarization. A polarized image pol = parallel - perpendicular / parallel + perpendicular is generated. This image has a higher contrast to the superficial skin layers than simple total reflectance images. Pilot clinical trials were conducted with a small hand-held device for the accumulation of a library of lesions to establish the efficacy of polarized light imaging in vivo. It was found that melanoma exhibits a high contrast to polarized light imaging as well as basal and sclerosing cell carcinoma. Mechanisms of polarized light scattering from different tissues and tissue phantoms were studied in vitro. Parameters such as depth of depolarization (DOD), retardance, and birefringence were studied in theory and experimentally. Polarized light traveling through different tissues (skin, muscle, and liver) depolarized after a few hundred microns. Highly birefringent materials such as skin (DOD = 300 mum 696nm) and muscle (DOD = 370 mum 696nm) depolarized light faster than less birefringent materials such as liver (DOD = 700 mum 696nm). Light depolarization can also be attributed to scattering. Three Monte Carlo programs for modeling polarized light transfer into scattering media were implemented to evaluate these mechanisms. Simulations conducted with the Monte Carlo programs showed that small diameter spheres have different mechanisms of depolarization than larger ones. The models also showed that the anisotropy parameter g strongly influences the depolarization mechanism. (Abstract shortened by UMI.)

  9. Empirical recommendations for improving the stability of the dot-probe task in clinical research.

    PubMed

    Price, Rebecca B; Kuckertz, Jennie M; Siegle, Greg J; Ladouceur, Cecile D; Silk, Jennifer S; Ryan, Neal D; Dahl, Ronald E; Amir, Nader

    2015-06-01

    The dot-probe task has been widely used in research to produce an index of biased attention based on reaction times (RTs). Despite its popularity, very few published studies have examined psychometric properties of the task, including test-retest reliability, and no previous study has examined reliability in clinically anxious samples or systematically explored the effects of task design and analysis decisions on reliability. In the current analysis, we used dot-probe data from 3 studies in which attention bias toward threat-related faces was assessed at multiple (≥5) time-points. Two of the studies were similar (adults with social anxiety disorder, similar design features) whereas 1 was more disparate (pediatric healthy volunteers, distinct task design). We explored the effects of analysis choices (e.g., bias score formula, outlier handling method) on reliability and searched for convergent findings across the 3 studies. We found that, when concurrently considering the 3 studies, the most reliable RT index of bias used data from dot-bottom trials, comparing congruent to incongruent trials, with rescaled outliers, particularly after averaging across more than 1 assessment point. Although reliability of RT bias indices was moderate to low, within-session variability in bias (attention bias variability; ABV), a recently proposed RT index, was more reliable across sessions. Several eyetracking-based indices of attention bias (available in the pediatric healthy sample only) showed reliability that matched the optimal RT index (ABV). On the basis of these findings, we make specific recommendations to researchers using the dot-probe, particularly those wishing to investigate individual differences and/or single-patient applications. PMID:25419646

  10. Empirical Recommendations for Improving the Stability of the Dot-Probe Task in Clinical Research

    PubMed Central

    Price, Rebecca B.; Kuckertz, Jennie M.; Siegle, Greg J.; Ladouceur, Cecile D.; Silk, Jennifer S.; Ryan, Neal D.; Dahl, Ronald E.; Amir, Nader

    2014-01-01

    The dot-probe task has been widely used in research to produce an index of biased attention based on reaction times (RTs). Despite its popularity, very few published studies have examined psychometric properties of the task, including test-retest reliability, and no previous study has examined reliability in clinically anxious samples or systematically explored the effects of task design and analysis decisions on reliability. In the current analysis, we utilized dot-probe data from three studies where attention bias towards threat-related faces was assessed at multiple (≥5) timepoints. Two of the studies were similar (adults with Social Anxiety Disorder, similar design features) while one was much more disparate (pediatric healthy volunteers, distinct task design). We explored the effects of analysis choices (e.g., bias score calculation formula, methods for outlier handling) on reliability and searched for convergence of findings across the three studies. We found that, when considering the three studies concurrently, the most reliable RT bias index utilized data from dot-bottom trials, comparing congruent to incongruent trials, with rescaled outliers, particularly after averaging across more than one assessment point. Although reliability of RT bias indices was moderate to low under most circumstances, within-session variability in bias (attention bias variability; ABV), a recently proposed RT index, was more reliable across sessions. Several eyetracking-based indices of attention bias (available in the pediatric healthy sample only) showed reliability that matched the optimal RT index (ABV). On the basis of these findings, we make specific recommendations to researchers using the dot probe, particularly those wishing to investigate individual differences and/or single-patient applications. PMID:25419646

  11. Empirical Correlates and Expanded Interpretation of the MMPI-2-RF Restructured Clinical Scale 3 (Cynicism)

    ERIC Educational Resources Information Center

    Ingram, Paul B.; Kelso, Kristy M.; McCord, David M.

    2011-01-01

    The recent release of the Minnesota Multiphasic Personality Inventory-2-Restructured Form (MMPI-2-RF) has received much attention from the clinical psychology community. Particular concerns have focused on Restructured Clinical Scale 3 (RC3; Cynicism). This article briefly reviews the major criticisms and responses regarding the restructuring of…

  12. Empirically and Clinically Useful Decision Making in Psychotherapy: Differential Predictions with Treatment Response Models

    ERIC Educational Resources Information Center

    Lutz, Wolfgang; Saunders, Stephen M.; Leon, Scott C.; Martinovich, Zoran; Kosfelder, Joachim; Schulte, Dietmar; Grawe, Klaus; Tholen, Sven

    2006-01-01

    In the delivery of clinical services, outcomes monitoring (i.e., repeated assessments of a patient's response to treatment) can be used to support clinical decision making (i.e., recurrent revisions of outcome expectations on the basis of that response). Outcomes monitoring can be particularly useful in the context of established practice research…

  13. Implementing community-based provider participation in research: an empirical study

    PubMed Central

    2012-01-01

    Background Since 2003, the United States National Institutes of Health (NIH) has sought to restructure the clinical research enterprise in the United States by promoting collaborative research partnerships between academically-based investigators and community-based physicians. By increasing community-based provider participation in research (CBPPR), the NIH seeks to advance the science of discovery by conducting research in clinical settings where most people get their care, and accelerate the translation of research results into everyday clinical practice. Although CBPPR is seen as a promising strategy for promoting the use of evidence-based clinical services in community practice settings, few empirical studies have examined the organizational factors that facilitate or hinder the implementation of CBPPR. The purpose of this study is to explore the organizational start-up and early implementation of CBPPR in community-based practice. Methods We used longitudinal, case study research methods and an organizational model of innovation implementation to theoretically guide our study. Our sample consisted of three community practice settings that recently joined the National Cancer Institute’s (NCI) Community Clinical Oncology Program (CCOP) in the United States. Data were gathered through site visits, telephone interviews, and archival documents from January 2008 to May 2011. Results The organizational model for innovation implementation was useful in identifying and investigating the organizational factors influencing start-up and early implementation of CBPPR in CCOP organizations. In general, the three CCOP organizations varied in the extent to which they achieved consistency in CBPPR over time and across physicians. All three CCOP organizations demonstrated mixed levels of organizational readiness for change. Hospital management support and resource availability were limited across CCOP organizations early on, although they improved in one CCOP organization

  14. Hospital restructuring and physician job satisfaction: an empirical study.

    PubMed

    Mascia, Daniele; Morandi, Federica; Cicchetti, Americo

    2014-02-01

    The adoption of clinical directorates through the internal reconfiguration of hospital organizations has been one of the most widespread restructuring interventions in many Western European countries. Despite its extensive adoption, a lack of knowledge remains on the analysis of how this reorganization affects professionals' job satisfaction. This paper contributes to the debate on clinical directorates by exploring how the structural characteristics of newly adopted organizational models influence physician's job satisfaction. More than 300 physicians in 18 clinical directorates in the Italian National Health Service were surveyed regarding their overall job satisfaction following the introduction of departmental arrangements. Survey results were then linked to another survey that classified newly adopted models according to the criteria used to merge hospital wards into directorates, by recognizing "Process-integration", "Specialty-integration" and "Mixed-integration" types of directorates. Our findings show that structural aspects of change significantly influenced overall job satisfaction, and that a physician's openness to experience moderated the adoption and implementation of new clinical directorates. Specifically, results demonstrate that physicians with high openness to experience scores were more receptive to the positive impacts of change on overall job satisfaction. Implications for how these findings may facilitate organizational shifts within hospital settings are discussed. PMID:24314626

  15. From empirical to mechanism-based discovery of clinically useful Selective Estrogen Receptor Modulators (SERMs)

    PubMed Central

    Wardell, Suzanne E.; Nelson, Erik R.; McDonnell, Donald P.

    2014-01-01

    Our understanding of the molecular mechanisms underlying the pharmacological actions of estrogen receptor (ER) ligands has evolved considerably in recent years. Much of this knowledge has come from a detailed dissection of the mechanism(s) of action of the Selective Estrogen Receptor Modulators (SERMs) tamoxifen and raloxifene, drugs whose estrogen receptor (ER) agonist/antagonist properties are influenced by the cell context in which they operate. These studies have revealed that notwithstanding differences in drug pharmokinetics, the activity of an ER ligand is determined primarily by (a) the impact that a given ligand has on the receptor conformation and (b) the ability of structurally distinct ER-ligand complexes to interact with functionally distinct coregulators. Exploitation of the established relationships between ER structure and activity has led to the development of improved SERMs with more favorable therapeutic properties and of tissue-selective estrogen complexes, drugs in which a SERM and an ER agonist are combined to yield a blended activity that results in distinct clinical profiles. Remarkably, endogenous ligands that exhibit SERM activity have also been identified. One of these ligands, 27-hydroxycholesterol (27HC), has been shown to manifest ER-dependent pathological activities in the cardiovascular system, bone and mammary gland. Whereas the physiological activity of 27HC remains to be determined, its discovery highlights how cells have adopted mechanisms to allow the same receptor ligand complex to manifest different activities in different cells, and also how these processes can be exploited for new drug development. PMID:25084324

  16. Clinicians' emotional responses and Psychodynamic Diagnostic Manual adult personality disorders: A clinically relevant empirical investigation.

    PubMed

    Gazzillo, Francesco; Lingiardi, Vittorio; Del Corno, Franco; Genova, Federica; Bornstein, Robert F; Gordon, Robert M; McWilliams, Nancy

    2015-06-01

    The aim of this study is to explore the relationship between level of personality organization and type of personality disorder as assessed with the categories in the Psychodynamic Diagnostic Manual (PDM; PDM Task Force, 2006) and the emotional responses of treating clinicians. We asked 148 Italian clinicians to assess 1 of their adult patients in treatment for personality disorders with the Psychodiagnostic Chart (PDC; Gordon & Bornstein, 2012) and the Personality Diagnostic Prototype (PDP; Gazzillo, Lingiardi, & Del Corno, 2012) and to complete the Therapist Response Questionnaire (TRQ; Betan, Heim, Zittel-Conklin, & Westen, 2005). The patients' level of overall personality pathology was positively associated with helpless and overwhelmed responses in clinicians and negatively associated with positive emotional responses. A parental and disengaged response was associated with the depressive, anxious, and dependent personality disorders; an exclusively parental response with the phobic personality disorder; and a parental and criticized response with narcissistic disorder. Dissociative disorder evoked a helpless and parental response in the treating clinicians whereas somatizing disorder elicited a disengaged reaction. An overwhelmed and disengaged response was associated with sadistic and masochistic personality disorders, with the latter also associated with a parental and hostile/criticized reaction; an exclusively overwhelmed response with psychopathic patients; and a helpless response with paranoid patients. Finally, patients with histrionic personality disorder evoked an overwhelmed and sexualized response in their clinicians whereas there was no specific emotional reaction associated with the schizoid and the obsessive-compulsive disorders. Clinical implications of these findings were discussed. PMID:25868053

  17. Practical Implications of Empirically Studying Moral Decision-Making

    PubMed Central

    Heinzelmann, Nora; Ugazio, Giuseppe; Tobler, Philippe N.

    2012-01-01

    This paper considers the practical question of why people do not behave in the way they ought to behave. This question is a practical one, reaching both into the normative and descriptive domains of morality. That is, it concerns moral norms as well as empirical facts. We argue that two main problems usually keep us form acting and judging in a morally decent way: firstly, we make mistakes in moral reasoning. Secondly, even when we know how to act and judge, we still fail to meet the requirements due to personal weaknesses. This discussion naturally leads us to another question: can we narrow the gap between what people are morally required to do and what they actually do? We discuss findings from neuroscience, economics, and psychology, considering how we might bring our moral behavior better in line with moral theory. Potentially fruitful means include nudging, training, pharmacological enhancement, and brain stimulation. We conclude by raising the question of whether such methods could and should be implemented. PMID:22783157

  18. Perilous periodontitis: a clinical study.

    PubMed

    Emmanuel, Roby V; Neelakantan, Shiba

    2011-12-01

    The aim of this study is to determine whether periodontitis in pregnant women could be a risk factor for pre term low birth weight. The oral hygiene status, periodontal status and periodontal treatment needs of mothers who birthed infants with normal birth weight and normal gestation period (group A) and mothers who birthed pre term low birth weight infants (group B) were assessed and compared. The clinical parameters used were Oral Hygiene Index--simplified (OHI-S), gingival bleeding index (GBI), probing pocket depth and Community Periodontal Index of Treatment Needs (CPITN). This article presents the study and its findings and draws conclusions as to the relationship between poor periodontal condition and pre term low birth weight. PMID:22216586

  19. In Search of the Unifying Principles of Psychotherapy: Conceptual, Empirical, and Clinical Convergence

    ERIC Educational Resources Information Center

    Magnavita, Jeffrey J.

    2006-01-01

    The search for the principles of unified psychotherapy is an important stage in the advancement of the field. Converging evidence from various streams of clinical science allows the identification of some of the major domains of human functioning, adaptation, and dysfunction. These principles, supported by animal modeling, neuroscience, and…

  20. Empirical studies of software design: Implications for SSEs

    NASA Technical Reports Server (NTRS)

    Krasner, Herb

    1988-01-01

    Implications for Software Engineering Environments (SEEs) are presented in viewgraph format for characteristics of projects studied; significant problems and crucial problem areas in software design for large systems; layered behavioral model of software processes; implications of field study results; software project as an ecological system; results of the LIFT study; information model of design exploration; software design strategies; results of the team design study; and a list of publications.

  1. A pilot study of the efficacy and safety of empiric daptomycin therapy in oncology patients with fever and severe neutropenia

    PubMed Central

    Kullar, Ravina; Maziarz, Richard T.

    2013-01-01

    Objectives: Patients with extended periods of time spent with low or absent absolute neutrophil counts (ANCs) are at risk for bacterial infections. Febrile neutropenia is a complication in this patient population, requiring administration of antibiotics. The use of daptomycin in treating patients with febrile neutropenia is not well described. Our objective was to describe the clinical course of febrile neutropenic patients that received daptomycin therapy. Methods: This was an open-labeled, pilot study of 30 patients with documented febrile neutropenia treated with empiric daptomycin. Eligible patients received daptomycin 6 mg/kg/day, in addition to concomitant broad-spectrum antimicrobials. The Kaplan–Meier method was used to estimate the median days to reach an afebrile state and negative bacterial cultures. Results: A total of 30 febrile neutropenic patients were enrolled and received daptomycin as part of an empiric antimicrobial regimen. All patients had severe neutropenia with ANC <100 cells/mm3. Two patients were removed from study due to the development of pneumonia. Clinically, 87% patients improved on daptomycin in combination with Gram-negative coverage, with 73% of patients succeeding therapy. A total of 18 of 19 (95%) subjects with positive blood cultures had microbiological eradication, with the median time to reach an afebrile state of 4.3 days (range 1–13). Four patients were discontinued from daptomycin due to a suspected related adverse event or to clinical failure. Conclusions: This pilot study supports future evaluation of the use of empiric daptomycin therapy in combination with Gram-negative coverage compared with vancomycin in patients with neutropenic fever in a large, randomized controlled trial. PMID:25165552

  2. How Culture Affects Female Inequality across Countries: An Empirical Study

    ERIC Educational Resources Information Center

    Cheung, Hoi Yan; Chan, Alex W. H.

    2007-01-01

    Many studies have commented that culture has an influence on gender inequality. However, few studies have provided data that could be used to investigate how culture actually influences female inequality. One of the aims of this study is to investigate whether Hofstede's cultural dimensions have an impact on female inequality in education in terms…

  3. An Empirical Review of Internet Addiction Outcome Studies in China

    ERIC Educational Resources Information Center

    Liu, Chennan; Liao, Minli; Smith, Douglas C.

    2012-01-01

    Objectives: The authors systematically reviewed the outcomes and methodological quality of 24 Internet addiction (IA) treatment outcome studies in China. Method: The authors used 15 attributes from the quality of evidence scores to evaluate 24 outcome studies. These studies came from both English and Chinese academic databases from 2000 to 2010.…

  4. Administrators' Attitudes toward Cultural Diversity Management: An Empirical Study;

    ERIC Educational Resources Information Center

    Mohapatra, Manindra K.; And Others

    A study was done to test four hypotheses on the orientation of American Urban Administrators toward cultural diversity management in the public sector workplace. The study sought to test: (1) the extent of familiarity with the literature on cultural diversity; (2) relative ranking of cultural diversity management capabilities; (3) how women and…

  5. An Empirical Study of Long Term Effects of Education.

    ERIC Educational Resources Information Center

    Harnqvist, Kjell

    A large-scale study of Swedish men and women, each of whose intelligence level at age 13 was above the 25th percentile and whose father's education was only at the elementary level, was conducted in order to determine what educational level the participants had achieved and to study long-term effects of schooling. Subjects were sent questionnaires…

  6. Academic Probation: An Empirical Study of Private University Students

    ERIC Educational Resources Information Center

    Ahmed, Jashim Uddin; Chowdhury, Md. Humayun Kabir; Rahman, Sheehan; Talukder, A. K. M. Mominul Haque

    2014-01-01

    This study examines the factors contributing to academic probation in university settings and highlights the problems that students encounter in higher education institutions in Bangladesh. The study focused on students facing academic probation on two private universities in Bangladesh and analyzed students' response with respect to nine…

  7. An Empirical Study of Pupils' Attitudes to Computers and Robots.

    ERIC Educational Resources Information Center

    Moore, J. L.

    1985-01-01

    Describes a study which utilized a Likert type questionnaire to assess seven scales of secondary pupils' attitudes toward computers and robotics (school, leisure, career, employment, social, threat, future) and investigated pupils' scores on functions of their sex, general academic ability, course of study, and microcomputer experience. (MBR)

  8. An Empirical Study of a Solo Performance Assessment Model

    ERIC Educational Resources Information Center

    Russell, Brian E.

    2015-01-01

    The purpose of this study was to test a hypothesized model of solo music performance assessment. Specifically, this study investigates the influence of technique and musical expression on perceptions of overall performance quality. The Aural Musical Performance Quality (AMPQ) measure was created to measure overall performance quality, technique,…

  9. Using MultiMedia Content to Present Business Ethics: An Empirical Study

    ERIC Educational Resources Information Center

    Stanwick, Peter A.

    2010-01-01

    The purpose of this study is to empirically examine whether presenting a multimedia case study enhances the learning experience of students in an undergraduate management class. A questionnaire was administered before and after the presentation of the case study and the results showed that the multimedia case did indeed enhance the learning…

  10. Website Service Quality in Ireland: An Empirical Study

    NASA Astrophysics Data System (ADS)

    Connolly, Regina

    Despite the fact that service quality is a critical determinant of website success, studies show that consumers frequently view the service quality delivered through websites as unsatisfactory. This paper outlines a study that investigated the dimensions of website service excellence valued by Irish customers of a small-to-medium enterprise specialising in gifts. The E-S-QUAL measurement instrument was applied to the customers who purchase products online from this retailer, in order to determine their purchasing patterns and the dimensions of e-service quality that they value. The results of this study indicate the effectiveness of the instrument in determining gaps in e-service quality. The findings will be of benefit both to practitioners and researchers seeking to improve their understanding of the factors that contribute towards the creation and maintenance of consumer satisfaction in Irish online transactions.

  11. User acceptance of mobile commerce: an empirical study in Macau

    NASA Astrophysics Data System (ADS)

    Lai, Ivan K. W.; Lai, Donny C. F.

    2014-06-01

    This study aims to examine the positive and negative factors that can significantly explain user acceptance of mobile commerce (m-commerce) in Macau. A technology acceptance model for m-commerce with five factors is constructed. The proposed model is tested using data collected from 219 respondents. Confirmatory factor analysis is performed to examine the reliability and validity of the model, and structural equation modelling is performed to access the relationship between behaviour intention and each factor. The acceptance of m-commerce is influenced by factors including performance expectancy, social influence, facilitating conditions and privacy concern; while effort expectancy is insignificant in this case. The results of the study are useful for m-commerce service providers to adjust their strategies for promoting m-commerce services. This study contributes to the practice by providing a user technology acceptance model for m-commerce that can be used as a foundation for future research.

  12. Trend extraction using empirical mode decomposition and statistical empirical mode decomposition: Case study: Kuala Lumpur stock market

    NASA Astrophysics Data System (ADS)

    Jaber, Abobaker M.

    2014-12-01

    Two nonparametric methods for prediction and modeling of financial time series signals are proposed. The proposed techniques are designed to handle non-stationary and non-linearity behave and to extract meaningful signals for reliable prediction. Due to Fourier Transform (FT), the methods select significant decomposed signals that will be employed for signal prediction. The proposed techniques developed by coupling Holt-winter method with Empirical Mode Decomposition (EMD) and it is Extending the scope of empirical mode decomposition by smoothing (SEMD). To show performance of proposed techniques, we analyze daily closed price of Kuala Lumpur stock market index.

  13. Group Performance in Information Systems Project Groups: An Empirical Study

    ERIC Educational Resources Information Center

    Bahli, Bouchaib; Buyukkurt, Meral Demirbag

    2005-01-01

    The importance of teamwork in Information Systems Development (ISD) practice and education has been acknowledged but not studied extensively to date. This paper tests a model of how groups participating in ISD projects perform and examines the relationships between some antecedents of this performance based on group research theory well…

  14. An Empirical Study of State University Students' Perceived Service Quality

    ERIC Educational Resources Information Center

    Sumaedi, Sik; Bakti, Gede Mahatma Yuda; Metasari, Nur

    2012-01-01

    Purpose: This paper aims to identify: university students' perceived service quality dimensions; the dimensions contributing most towards overall students' perceived service quality; and whether there is a difference in perceived quality level of each dimension based on students' year of study and gender in the context of undergraduate students of…

  15. Management Education Program Evaluation: An Empirical Study in Mainland China

    ERIC Educational Resources Information Center

    Sou, Gryphon; Zhou, Pinqiu

    2007-01-01

    Background: With the accession of the PRC to the WTO, Chinese education market is open to the educational service providers of the foreign countries. They are keen to offer MBA Degree programs to the Career Managers in the Mainland. Aims: This research studies program evaluation and so forth the quality assessment of a MBA degree program in the…

  16. Individual Differences, Hypermedia Navigation, and Learning: An Empirical Study.

    ERIC Educational Resources Information Center

    Ford, Nigel; Chen, Sherry Y.

    2000-01-01

    Describes a study conducted at the University of Sheffield (United Kingdom) that measured the learning behavior and performance of 65 postgraduate students using a hypermedia-based tutorial. Considers cognitive style, levels of prior experience, motivation, age, gender, and navigation patterns. (Author/LRW)

  17. An Empirical Study of Graduate Student Mobility Underpinning Research Universities

    ERIC Educational Resources Information Center

    Furukawa, Takao; Shirakawa, Nobuyuki; Okuwada, Kumi

    2013-01-01

    The issue of international student mobility has had a profound effect on policy decision-making in the higher education system of essentially every country; however, the statistical data on this subject are insufficient, especially for graduate students. The purposes of this study are to substantiate the state of international mobility among…

  18. The Depth and Breadth of Google Scholar: An Empirical Study

    ERIC Educational Resources Information Center

    Neuhaus, Chris; Neuhaus, Ellen; Asher, Alan; Wrede, Clint

    2006-01-01

    The introduction of Google Scholar in November 2004 was accompanied by fanfare, skepticism, and numerous questions about the scope and coverage of this database. Nearly one year after its inception, many of these questions remain unanswered. This study compares the contents of 47 different databases with that of Google Scholar. Included in this…

  19. An Empirical Study on Students' Ability to Comprehend Design Patterns

    ERIC Educational Resources Information Center

    Chatzigeorgiou, Alexander; Tsantalis, Nikolaos; Deligiannis, Ignatios

    2008-01-01

    Design patterns have become a widely acknowledged software engineering practice and therefore have been incorporated in the curricula of most computer science departments. This paper presents an observational study on students' ability to understand and apply design patterns. Within the context of a postgraduate software engineering course,…

  20. Student Stress in an FE College: An Empirical Study.

    ERIC Educational Resources Information Center

    Hayward, Abbe; Stott, Clare

    1998-01-01

    A study was conducted of student stress in a further education (FE) college in northwest England. In collaboration with the college, two questionnaires were developed, one for the teaching staff and the other for the students. Questionnaires were distributed to 69 staff and 1,100 students, with a response rate of 94 percent from staff and 84…

  1. Creativity, Schizotypicality, and Mystical Experience: An Empirical Study

    ERIC Educational Resources Information Center

    Michalica, Kerri; Hunt, Harry

    2013-01-01

    This study examined the commonalities and the differences between creativity and the schizophrenia spectrum. The variables measured were creativity, schizotypy, absorption, mystical experiences, spatial ability, balance, positive and negative presence, and neuroticism. Three community groups were recruited: 31 artists, 10 people with…

  2. IT Entrepreneurial Intention among College Students: An Empirical Study

    ERIC Educational Resources Information Center

    Chen, Liqiang

    2013-01-01

    IT (Information Technology) entrepreneurs have been contributing greatly to economic growth and job creation. Despite its importance, IT entrepreneurship remains understudied in business research. Particularly, the study of IT entrepreneurial behavior has been ignored in both Information Systems (IS) and entrepreneurship disciplines. Utilizing the…

  3. Effect of Geographic Distance on Distance Education: An Empirical Study

    ERIC Educational Resources Information Center

    Luo, Heng; Robinson, Anthony C.; Detwiler, Jim

    2014-01-01

    This study investigates the effect of geographic distance on students' distance learning experience with the aim to provide tentative answers to a fundamental question--does geographic distance matter in distance education? Using educational outcome data collected from an online master's program in Geographic Information Systems, this…

  4. Job Satisfaction of Academic Staff: An Empirical Study on Turkey

    ERIC Educational Resources Information Center

    Toker, Boran

    2011-01-01

    Purpose: The purpose of this paper is to investigate the levels of job satisfaction among academicians in the universities of Turkey and to examine the effects of demographics on levels of satisfaction among them. Design/methodology/approach: A questionnaire-based study was conducted in 648 academicians working in the Universities of Turkey. Data…

  5. Factors Affecting Softlifting Intention of Computing Students: An Empirical Study.

    ERIC Educational Resources Information Center

    Rahim, Md. Mahbubur; Seyal, Afzaal H.; Rahman, Mohd. Noah Abd.

    2001-01-01

    Discusses softlifting as a form of software piracy and describes a study that analyzed the softlifting intentions of computing students in Brunei Darussalam. Considers student attitudes; gender; family income; personal computer ownership; experience; faculty remarks; institutional monitoring; and implications for attempts to curb software piracy.…

  6. Creativity and Tolerance of Ambiguity: An Empirical Study

    ERIC Educational Resources Information Center

    Zenasni, Franck; Besancon, Maud; Lubart, Todd

    2008-01-01

    This study examines the relationship between creativity and tolerance of ambiguity. Participants were parents and their adolescent children. Three measures of creativity were used: a divergent thinking task, a story-writing task and self-evaluation of creative attitudes and behavior. Participants completed two self-report measures of tolerance of…

  7. An Empirical Study of Pronunciation Errors in French.

    ERIC Educational Resources Information Center

    Walz, Joel

    1980-01-01

    Presents results of a study that sought to test the pronunciation problems of a large number of American students in a beginning college-level French course. Learner difficulties over a 15-week period were used to create a hierarchy of minimal contrasts representing major, secondary, and minor problems for the students in learning French sounds.…

  8. Note-Taking and Information Recall: An Empirical Study

    ERIC Educational Resources Information Center

    May, Jerry R.; Miller, Paul R.

    1977-01-01

    The amount of recorded information from a medical interview by note-taking was compared with that received with no note-taking. The study with 46 medical students suggests that note-taking facilitates recall and that there is a progressive decay of memory recall with the passage of time between the physician-patient interview and the recording of…

  9. Similarity Attraction in Learning Contexts: An Empirical Study

    ERIC Educational Resources Information Center

    Varela, Otmar E.; Cater, John James, III; Michel, Norbert

    2011-01-01

    This study tests a process model of learning in which trainer and trainee traits are simultaneously considered as endogenous variables of learning outcomes. The article builds on a social view of training and similarity-attraction paradigms. In this context, the authors hypothesize that trainer-trainee similarity in personality (agreeableness)…

  10. Self-Efficacy and IPS: An Empirical Study

    ERIC Educational Resources Information Center

    McLeod, Linda P.

    2015-01-01

    The fact that some learners learn language more successfully than others who are at the same level of aptitude and capabilities is inevitable. To understand why, the researcher has focused her attention on individual differences among learners. The ones that have been taken into account in this study are namely called self-efficacy and identity…

  11. An empirical evaluation of devolving administrative control to Costa Rican hospital and clinic directors.

    PubMed

    Lee, Theodore; McKee, Douglas

    2015-01-01

    In the early 2000s, Costa Rica implemented comprehensive reforms of its health care system, including devolving administrative power from the central government to some providers that remain part of the national system. In this article, we evaluate how this aspect of the reform affected clinic efficiency and population health by analyzing administrative data on regional providers and mortality rates in local areas. We compare changes in outcomes across time between areas that signed performance contracts with the central government and received limited budgetary control to those that continued to be managed directly by the central government. We believe the reform created opportunities for providers to become more efficient and effective. Our results suggest that the reform significantly decreased costs without adversely affecting quality of care or population health. PMID:25813506

  12. Sustaining the environment through recycling: an empirical study.

    PubMed

    Ramayah, T; Lee, Jason Wai Chow; Lim, Shuwen

    2012-07-15

    This paper examines the determinants of recycling behaviour among 200 university students from the perspective of the theory of planned behaviour (TPB). Data was analysed using Structural Equation Modelling technique. Findings indicate that environmental awareness was significantly related to attitude towards recycling, whilst attitude and social norms had significant impact on recycling behaviour. However, convenience and cost of recycling were not significant reasons for recycling. The study has enhanced the understanding of the determinants of recycling behaviour and has implications for schools and governmental agencies in educating and encouraging positive recycling behaviour. It also confirms the appropriateness of the TPB in examining studies of this nature. Further suggestions for future research are offered. PMID:22446140

  13. An empirical study of defense mechanisms in panic disorder.

    PubMed

    Busch, F N; Shear, M K; Cooper, A M; Shapiro, T; Leon, A C

    1995-05-01

    Psychodynamic factors have rarely been systematically studied in panic disorder, despite indications that these factors may be important in the understanding and treatment of panic. This is a report of a study using the Defense Mechanism Rating Scale to test the hypothesis that patients with panic disorder utilize particular defense mechanisms: reaction formation, undoing, and displacement. The use of defense mechanisms in 22 patients with primary panic disorder was compared with that of 22 patients with primary dysthymic disorder, based on Defense Mechanism Rating Scale ratings of psychodynamic interviews of these patients. Panic subjects scored significantly higher than dysthymics on the defenses of reaction formation and undoing, but not on the defense of displacement. The defense mechanisms found are consistent with a proposed psychodynamic formulation for panic disorder that emphasizes the panic patient's difficulty in tolerating angry feelings toward significant others. Knowledge of these defense mechanisms can be useful for various treatment approaches in panic disorder. PMID:7745383

  14. Aspect-Oriented Approach to Operating System Development Empirical Study

    NASA Astrophysics Data System (ADS)

    Kuusela, Jaakko; Tuominen, Harri

    This paper presents a case-study where a new programming technique is applied to an established branch of software development. The purpose of the study was to test whether or not aspect-oriented programming (AOP) could be used in operating systems development. Instead of any real world operating system an educational OS with the name Nachos was used. This was because Nachos is written in Java which makes it easy to introduce aspect-oriented techniques. In this paper a new file system for the Nachos OS is developed and then it is analyzed by profiling and metrics. The results show that it is possible to use AOP in OS development and that it is also beneficial to do so.

  15. A Formulative and Empirical Study of Black Families. Final Report.

    ERIC Educational Resources Information Center

    Nobles, Wade; And Others

    This research study on the black family was based on the position that black culture in the U.S. is the result of a special admixture of the continuation of an African world-view or cultural perspective which operates within the perspective of an Anglo-American world-view. Because this research is guided by this position, it is viewed as a…

  16. Portuguese validation of the Internet Addiction Test: An empirical study

    PubMed Central

    PONTES, HALLEY M.; PATRÃO, IVONE M.; GRIFFITHS, MARK D.

    2014-01-01

    Background and aims: Research into Internet addiction (IA) has increased greatly over the last decade. Despite its various definitions and general lack of consensus regarding its conceptualisation amongst researchers, instruments for measuring this phenomenon have proliferated in a number of countries. There has been little research on IA in Portugal and this may be partly due to the absence of standardised measurement tools for assessing IA. Methods: This study attempted to address this issue by adapting a Portuguese version of the Internet Addiction Test (IAT) via a translation-back translation process and Confirmatory Factor Analysis in a sample of 593 Portuguese students that completed a Portuguese version of the IAT along with questions related to socio-demographic variables. Results: The findings suggested that the IAT appears to be a valid and reliable instrument for measuring IA among Portuguese young adults as demonstrated by its satisfactory psychometric properties. However, the present findings also suggest the need to reword and update some of the IAT’s items. Prevalence of IA found in the sample was 1.2% and is discussed alongside findings relating to socio-demographic correlates. Limitations and implications of the present study are also discussed. Conclusions: The present study calls for a reflection of the IAT while also contributing to a better understanding of the basic aspects of IA in the Portuguese community since many health practitioners are starting to realise that Internet use may pose a risk for some individuals. PMID:25215221

  17. An empirical study of economies of scope in home healthcare.

    PubMed Central

    Gonzales, T I

    1997-01-01

    OBJECTIVE: To apply the economic theory of economies of scope to the home healthcare industry. DATA SOURCES: Data on 488 observations obtained from the Cost Report (HCFA Form 1728-86) of all Connecticut state-licensed, Medicare-certified home health agencies. STUDY DESIGN: The Cost Report was the primary source of data for this study. Information on total cost, scope, and other related factors was collected. Logarithmic and nonlinear regression analyses were used to identify factors related to scope and also to test for economies of scope. DATA COLLECTION METHOD: Data collected were both cross-sectional and time series (from 1988-1992). Data accuracy was verified using description of frequencies, measures of central tendency and variation, and a calculation package so that a computer calculation on the data could be compared with the agency's calculation. PRINCIPAL FINDINGS: It was determined that initially as scope increases, costs go down, thus proving economies of scope. For larger values of scope, it was determined that costs go up, proving diseconomies of scope. CONCLUSIONS: Many of the home health agencies included in this study provide more services than is cost effective given the economic theory of economies of scope. PMID:9240283

  18. Dissociation, PTSD, and Substance Abuse: An Empirical Study

    PubMed Central

    Najavits, Lisa; Walsh, Marybeth

    2012-01-01

    Few studies have examined the relationship between posttraumatic stress disorder (PTSD), substance use disorder (SUD) and dissociation. We studied 77 women with current PTSD and substance dependence, classified into high- versus low-dissociation on the Dissociative Experiences Scale. They were compared on trauma- and substance-related symptoms, cognitions, coping skills, social adjustment, trauma history, psychiatric symptoms, and self-harm/suicidal behaviors. We found the high-dissociation group consistently more impaired than the low-dissociation group. Also, the sample overall evidenced relatively high levels of dissociation, indicating that even in the presence of recent substance use, dissociation remains a major psychological phenomenon. Indeed, the high-dissociation group reported stronger expectation that substances could manage their psychiatric symptoms. The high-dissociation group also had more trauma-related symptoms and childhood histories of emotional abuse and physical neglect. Discussion addresses methodology, the “chemical dissociation” hypothesis, and the need for more nuanced understanding of how substances are experienced in relation to dissociative phenomena. PMID:22211445

  19. Dissociation, PTSD, and substance abuse: an empirical study.

    PubMed

    Najavits, Lisa M; Walsh, Marybeth

    2012-01-01

    Few studies have examined the relationship between posttraumatic stress disorder (PTSD), substance use disorder, and dissociation. We studied 77 women with current PTSD and substance dependence, classified into high- versus low-dissociation groups per the Dissociative Experiences Scale. They were compared on trauma- and substance-related symptoms, cognitions, coping skills, social adjustment, trauma history, psychiatric symptoms, and self-harm/suicidal behaviors. We found the high-dissociation group consistently more impaired than the low-dissociation group. Also, the sample overall evidenced relatively high levels of dissociation, indicating that even in the presence of recent substance use, dissociation remains a major psychological phenomenon. Indeed, the high-dissociation group reported stronger expectation that substances could manage their psychiatric symptoms. The high-dissociation group also had more trauma-related symptoms and childhood histories of emotional abuse and physical neglect. The discussion addresses methodology, the "chemical dissociation" hypothesis, and the need for a more nuanced understanding of how substances are experienced in relation to dissociative phenomena. PMID:22211445

  20. Consolidated View on Space Software Engineering Problems - An Empirical Study

    NASA Astrophysics Data System (ADS)

    Silva, N.; Vieira, M.; Ricci, D.; Cotroneo, D.

    2015-09-01

    Independent software verification and validation (ISVV) has been a key process for engineering quality assessment for decades, and is considered in several international standards. The “European Space Agency (ESA) ISVV Guide” is used for the European Space market to drive the ISVV tasks and plans, and to select applicable tasks and techniques. Software artefacts have room for improvement due to the amount if issues found during ISVV tasks. This article presents the analysis of the results of a large set of ISVV issues originated from three different ESA missions-amounting to more than 1000 issues. The study presents the main types, triggers and impacts related to the ISVV issues found and sets the path for a global software engineering improvement based on the most common deficiencies identified for space projects.

  1. An empirical study of flight control software reliability

    NASA Technical Reports Server (NTRS)

    Dunham, J. R.; Pierce, J. L.

    1986-01-01

    The results of a laboratory experiment in flight control software reliability are reported. The experiment tests a small sample of implementations of a pitch axis control law for a PA28 aircraft with over 14 million pitch commands with varying levels of additive input and feedback noise. The testing which uses the method of n-version programming for error detection surfaced four software faults in one implementation of the control law. The small number of detected faults precluded the conduct of the error burst analyses. The pitch axis problem provides data for use in constructing a model in the prediction of the reliability of software in systems with feedback. The study is undertaken to find means to perform reliability evaluations of flight control software.

  2. Behavioral Modeling Based on Probabilistic Finite Automata: An Empirical Study.

    PubMed

    Tîrnăucă, Cristina; Montaña, José L; Ontañón, Santiago; González, Avelino J; Pardo, Luis M

    2016-01-01

    Imagine an agent that performs tasks according to different strategies. The goal of Behavioral Recognition (BR) is to identify which of the available strategies is the one being used by the agent, by simply observing the agent's actions and the environmental conditions during a certain period of time. The goal of Behavioral Cloning (BC) is more ambitious. In this last case, the learner must be able to build a model of the behavior of the agent. In both settings, the only assumption is that the learner has access to a training set that contains instances of observed behavioral traces for each available strategy. This paper studies a machine learning approach based on Probabilistic Finite Automata (PFAs), capable of achieving both the recognition and cloning tasks. We evaluate the performance of PFAs in the context of a simulated learning environment (in this case, a virtual Roomba vacuum cleaner robot), and compare it with a collection of other machine learning approaches. PMID:27347956

  3. Empirical study of air quality in Barreiro city

    NASA Astrophysics Data System (ADS)

    Garcia, J. N.; Teodoroa, M. F.; Coelho, L. M.; Carvalho, M. G.

    2014-10-01

    The main objective of the work is to study the impact of air pollution on children's health in Portugal and more specifically in the city of Barreiro. We use the suitability of general linear methods (GLM) as a tool to estimate a model which relates air qualityand health. With detail, this relationship is investigated for the case of the effects of small particles on health. It was difficult to find clear and unambiguous correlations in particle dispersion, air quality and health. After a previous treatment of data, the models are estimated and validated by GLM. At the end of this process, the best models are selected using validation tests and residual analysis. The results are promising but some work using different statistical methods is ongoing.

  4. The Ease of Language Understanding (ELU) model: theoretical, empirical, and clinical advances

    PubMed Central

    Rönnberg, Jerker; Lunner, Thomas; Zekveld, Adriana; Sörqvist, Patrik; Danielsson, Henrik; Lyxell, Björn; Dahlström, Örjan; Signoret, Carine; Stenfelt, Stefan; Pichora-Fuller, M. Kathleen; Rudner, Mary

    2013-01-01

    Working memory is important for online language processing during conversation. We use it to maintain relevant information, to inhibit or ignore irrelevant information, and to attend to conversation selectively. Working memory helps us to keep track of and actively participate in conversation, including taking turns and following the gist. This paper examines the Ease of Language Understanding model (i.e., the ELU model, Rönnberg, 2003; Rönnberg et al., 2008) in light of new behavioral and neural findings concerning the role of working memory capacity (WMC) in uni-modal and bimodal language processing. The new ELU model is a meaning prediction system that depends on phonological and semantic interactions in rapid implicit and slower explicit processing mechanisms that both depend on WMC albeit in different ways. It is based on findings that address the relationship between WMC and (a) early attention processes in listening to speech, (b) signal processing in hearing aids and its effects on short-term memory, (c) inhibition of speech maskers and its effect on episodic long-term memory, (d) the effects of hearing impairment on episodic and semantic long-term memory, and finally, (e) listening effort. New predictions and clinical implications are outlined. Comparisons with other WMC and speech perception models are made. PMID:23874273

  5. [Patient satisfaction and geriatric care - an empirical study].

    PubMed

    Clausen, G; Borchelt, M; Janssen, C; Loos, S; Mull, L; Pfaff, H

    2006-02-01

    Patients' satisfaction has become a central concept in quality assurance. Despite progress in research in this area is still a lack of data for geriatric patients. Referring to the consumer model, satisfaction can be described as a difference between expectations and assessed performance. The aim of this study is to analyze satisfaction among geriatric patients in an in-patient setting. A personal interview was performed 1-2 days before discharge. Patients suffering for dementia or with problems to communicate were excluded. 124 of 268 geriatric patients who were discharged in 2003 were included (inclusion rate 46.3%). 119 were willing to participate (response rate 96.0%). Respondents were between 61 and 96 years old, 39% were male and 42% had serious functional limitations at time of admission. Multiple linear regression analysis revealed three significant predictors of a combined index of satisfaction and expectations: a) quality of hotel services; b) experience of neglect; c) provision of medical information and skills. In summary, standardized personal questionnaires can provide valid and reliable data of geriatric patients. Satisfaction of elderly patients is negatively affected by neglect and positively influenced by provision of medical information and a good hotel services. PMID:16502227

  6. Empirical study of simulated two-planet microlensing events

    SciTech Connect

    Zhu, Wei; Gould, Andrew; Penny, Matthew; Mao, Shude; Gendron, Rieul

    2014-10-10

    We undertake the first study of two-planet microlensing models recovered from simulations of microlensing events generated by realistic multiplanet systems in which 292 planetary events, including 16 two-planet events, were detected from 6690 simulated light curves. We find that when two planets are recovered, their parameters are usually close to those of the two planets in the system most responsible for the perturbations. However, in 1 of the 16 examples, the apparent mass of both detected planets was more than doubled by the unmodeled influence of a third, massive planet. This fraction is larger than but statistically consistent with the roughly 1.5% rate of serious mass errors due to unmodeled planetary companions for the 274 cases from the same simulation in which a single planet is recovered. We conjecture that an analogous effect due to unmodeled stellar companions may occur more frequently. For 7 out of 23 cases in which two planets in the system would have been detected separately, only one planet was recovered because the perturbations due to the two planets had similar forms. This is a small fraction (7/274) of all recovered single-planet models, but almost a third of all events that might plausibly have led to two-planet models. Still, in these cases, the recovered planet tends to have parameters similar to one of the two real planets most responsible for the anomaly.

  7. Personality Traits, Sexual Problems, and Sexual Orientation: An Empirical Study.

    PubMed

    Peixoto, Maria Manuela; Nobre, Pedro

    2016-04-01

    Personality traits, namely neuroticism, have been suggested as vulnerability factors for the development and maintenance of sexual dysfunction in heterosexual samples. However, no evidence was found regarding homosexual samples. This study aimed to analyze the differences on personality traits between heterosexual and homosexual men and women with and without sexual problems. Participants were 285 individuals (142 men, 143 women) who completed a web-based survey. Participants answered the NEO Five-Factor Inventory, the Brief Symptomatology Inventory, and questions regarding sexual problems. The groups of men and women with and without sexual problems were matched for sociodemographic variables. A 2 (Group) × 2 (Sexual Orientation) multivariate analysis of covariance was conducted separately for each gender. Results indicated a significant main effect for group and for sexual orientation in male and female samples. Men with sexual problems scored higher on neuroticism, whereas women with sexual problems scored higher on neuroticism and lower on extraversion when compared with healthy controls, regardless of sexual orientation. In addition, gay men scored higher on neuroticism and lesbian women scored higher on conscientiousness compared with the heterosexual groups. The present findings emphasize the central role of neuroticism on sexual problems in both men and women regardless of sexual orientation. PMID:25405957

  8. Experiences of time loss among videogame players: an empirical study.

    PubMed

    Wood, Richard T A; Griffiths, Mark D; Parke, Adrian

    2007-02-01

    Playing videogames is now a major leisure pursuit, yet research in the area is comparatively sparse. Previous correlational evidence suggests that subjective time loss occurs during playing videogames. This study examined experiences of time loss among a relatively large group of gamers (n = 280). Quantitative and qualitative data were collected through an online survey. Results showed that time loss occurred irrespective of gender, age, or frequency of play, but was associated with particular structural characteristics of games such as their complexity, the presence of multi-levels, missions and/or high scores, multiplayer interactions, and plot. Results also demonstrated that time loss could have both positive and negative outcomes for players. Positive aspects of time loss included helping players to relax and temporarily escape from reality. Negative aspects included the sacrificing of other things in their lives, guilty feelings about wasted time, and social conflict. It is concluded that for many gamers, losing track of time is a positive experience and is one of the main reasons for playing videogames. PMID:17305447

  9. The adoption of mobile health management services: an empirical study.

    PubMed

    Hung, Ming-Chien; Jen, Wen-Yuan

    2012-06-01

    As their populations age, many countries are facing the increasing economic pressure of providing healthcare to their people. In Taiwan, this problem is exacerbated by an increasing rate of obesity and obesity-related conditions. Encouraging the adoption of personal health management services is one way to maintain current levels of personal health and to efficiently manage the distribution of healthcare resources. This study introduces Mobile Health Management Services (MHMS) and employs the Technology Acceptance Model (TAM) to explore the intention of students in Executive Master of Business Management programs to adopt mobile health management technology. Partial least squares (PLS) was used to analyze the collected data, and the results revealed that "perceived usefulness" and "attitude" significantly affected the behavioral intention of adopting MHMS. Both "perceived ease of use" and "perceived usefulness," significantly affected "attitude," and "perceived ease of use" significantly affected "perceived usefulness" as well. The results also show that the determinants of intention toward MHMS differed with age; young adults had higher intention to adopt MHMS to manage their personal health. Therefore, relevant governmental agencies may profitably promote the management of personal health among this population. Successful promotion of personal health management will contribute to increases in both the level of general health and the efficient management of healthcare resources. PMID:20878452

  10. An Empirical Study of Different Approaches for Protein Classification

    PubMed Central

    Nanni, Loris

    2014-01-01

    Many domains would benefit from reliable and efficient systems for automatic protein classification. An area of particular interest in recent studies on automatic protein classification is the exploration of new methods for extracting features from a protein that work well for specific problems. These methods, however, are not generalizable and have proven useful in only a few domains. Our goal is to evaluate several feature extraction approaches for representing proteins by testing them across multiple datasets. Different types of protein representations are evaluated: those starting from the position specific scoring matrix of the proteins (PSSM), those derived from the amino-acid sequence, two matrix representations, and features taken from the 3D tertiary structure of the protein. We also test new variants of proteins descriptors. We develop our system experimentally by comparing and combining different descriptors taken from the protein representations. Each descriptor is used to train a separate support vector machine (SVM), and the results are combined by sum rule. Some stand-alone descriptors work well on some datasets but not on others. Through fusion, the different descriptors provide a performance that works well across all tested datasets, in some cases performing better than the state-of-the-art. PMID:25028675

  11. An empirical study on the college graduates' career development.

    PubMed

    Wang, Kuo-Lin

    2008-12-01

    Employment relations in Japan becomes flexible and uncertain in recent years. Career-related terms were widely introduced to Japan. Recent Japanese studies on career argued the responsibility of career development between the organization and individuals. This article discusses the determination of occupational choice and latter career development based on the interviews of Takasaki City University of Economics (TCUE) alumni. First, their ideals of vocational life before entering the labour market as well as their latter modification and development are examined. Second, their motivation for getting the first job is looked into. Finally, the ownership of individual career in Japanese firms is discussed by clarifying the way the interviewees become directors or leaders. The results show people engaged in a sole company have unclear career visions, but have stronger eagerness for being an ordinary salaried worker than others. Whatever one's dream is, getting a job for now would be a favourable attitude toward career development. The ownership of an employee's career still dominated by the organization could be confirmed. PMID:19227197

  12. Language Interdependence between American Sign Language and English: A Review of Empirical Studies

    ERIC Educational Resources Information Center

    Rusher, Melissa Ausbrooks

    2012-01-01

    This study provides a contemporary definition of American Sign Language/English bilingual education (AEBE) and outlines an essential theoretical framework. Included is a history and evolution of the methodology. The author also summarizes the general findings of twenty-six (26) empirical studies conducted in the United States that directly or…

  13. An Empirical Study to Aid in Formulating Educational Goals [and] Appendices.

    ERIC Educational Resources Information Center

    Flanagan, John C.; Russ-Eft, Darlene

    The objective of this survey study was to find some tentative answers to the question of how well educational programs are meeting the needs of students. The study design included several unique features intended to increase both the validity and the practical applicability of the results. The first feature was to establish an empirical framework…

  14. Short Stories via Computers in EFL Classrooms: An Empirical Study for Reading and Writing Skills

    ERIC Educational Resources Information Center

    Yilmaz, Adnan

    2015-01-01

    The present empirical study scrutinizes the use of short stories via computer technologies in teaching and learning English language. The objective of the study is two-fold: to examine how short stories could be used through computer programs in teaching and learning English and to collect data about students' perceptions of this technique via…

  15. An empirical study of gender differences in online gambling.

    PubMed

    McCormack, Abby; Shorter, Gillian W; Griffiths, Mark D

    2014-03-01

    Gambling has typically been considered a predominately male activity. However, recent prevalence surveys have shown greater numbers of females are now gambling. Much of the gambling literature suggests online gamblers are more likely to be male, and that problem gamblers are more likely to be male. Males and females are also likely to be gambling for different reasons and have a preference for different gambling activities. Little is known about the pattern of play among female online gamblers. The aim of this survey was to develop a better profile of female online gamblers and to examine any gender differences between males and females in terms of how and why they gamble online, their frequency of online gambling, patterns of play, as well as attitudes to online gambling. The survey was posted on 32 international online gambling websites and was completed by 975 online gamblers (including 175 female online gamblers). Chi-square tests of association were conducted to examine the association between gender and a range of variables. The results showed that females had been gambling online for a shorter duration of time than males, had much shorter online gambling sessions, different motivations for gambling online (i.e., to practice for free, to spend less money and out of boredom), and experienced online gambling differently to males, with increased feelings of guilt and shame for gambling online. This suggests there is still a stigma around gambling particularly evident among females in this study. The findings indicate that clinicians and treatment providers need to be aware of these potential gender differences in online gambling to develop appropriately tailored interventions. PMID:23097131

  16. Pedagogical strategies used in clinical medical education: an observational study

    PubMed Central

    2010-01-01

    Background Clinical teaching is a complex learning situation influenced by the learning content, the setting and the participants' actions and interactions. Few empirical studies have been conducted in order to explore how clinical supervision is carried out in authentic situations. In this study we explore how clinical teaching is carried out in a clinical environment with medical students. Methods Following an ethnographic approach looking for meaning patterns, similarities and differences in how clinical teachers manage clinical teaching; non-participant observations and informal interviews were conducted during a four month period 2004-2005. The setting was at a teaching hospital in Sweden. The participants were clinical teachers and their 4th year medical students taking a course in surgery. The observations were guided by the aim of the study. Observational notes and notes from informal interviews were transcribed after each observation and all data material was analysed qualitatively. Results Seven pedagogical strategies were found to be applied, namely: 1) Questions and answers, 2) Lecturing, 3) Piloting, 4) Prompting, 5) Supplementing, 6) Demonstrating, and 7) Intervening. Conclusions This study contributes to previous research in describing a repertoire of pedagogical strategies used in clinical education. The findings showed that three superordinate qualitatively different ways of teaching could be identified that fit Ramsden's model. Each of these pedagogical strategies encompass different focus in teaching; either a focus on the teacher's knowledge and behaviour or the student's behaviour and understanding. We suggest that an increased awareness of the strategies in use will increase clinical teachers' teaching skills and the consequences they will have on the students' ability to learn. The pedagogical strategies need to be considered and scrutinized in further research in order to verify their impact on students' learning. PMID:20105340

  17. Clinical Mental Health Counselor Handbook & Study Guide.

    ERIC Educational Resources Information Center

    Bullard, Bonnie; Lawless, Linda; Williams, Midge; Bergstrom, Deborah

    This handbook and study guide were developed as a textbook to be used as a review course for preparation for the clinical licensing examination. It presents a summary of a graduate level academic program in clinical mental health counseling. It contains 17 chapters on clinical information; 4 chapters on test taking; 2 types of sample tests; and 3…

  18. Empirically Derived Subtypes of Lifetime Anxiety Disorders: Developmental and Clinical Correlates in U.S. Adolescents

    ERIC Educational Resources Information Center

    Burstein, Marcy; Georgiades, Katholiki; Lamers, Femke; Swanson, Sonja A.; Cui, Lihong; He, Jian-Ping; Avenevoli, Shelli; Merikangas, Kathleen R.

    2012-01-01

    Objective: The current study examined the sex- and age-specific structure and comorbidity of lifetime anxiety disorders among U.S. adolescents. Method: The sample consisted of 2,539 adolescents (1,505 females and 1,034 males) from the National Comorbidity Survey-Adolescent Supplement who met criteria for "Diagnostic and Statistical Manual of…

  19. Prevalence of Clinically and Empirically Defined Talents and Strengths in Autism

    ERIC Educational Resources Information Center

    Meilleur, Andrée-Anne S.; Jelenic, Patricia; Mottron, Laurent

    2015-01-01

    Outstanding skills, including special isolated skills (SIS) and perceptual peaks (PP) are frequent features of autism. However, their reported prevalence varies between studies and their co-occurrence is unknown. We determined the prevalence of SIS in a large group of 254 autistic individuals and searched for PP in 46 of these autistic individuals…

  20. Model Selection for Equating Testlet-Based Tests in the NEAT Design: An Empirical Study

    ERIC Educational Resources Information Center

    He, Wei; Li, Feifei; Wolfe, Edward W.; Mao, Xia

    2012-01-01

    For those tests solely composed of testlets, local item independency assumption tends to be violated. This study, by using empirical data from a large-scale state assessment program, was interested in investigates the effects of using different models on equating results under the non-equivalent group anchor-test (NEAT) design. Specifically, the…

  1. The Status of Recent Experimental, Empirical, and Rhetorical Studies in the Teaching of Persuasion.

    ERIC Educational Resources Information Center

    Prentice, June Eleanor

    To determine the status of recent experimental, empirical, and rhetorical studies in teaching persuasion, a questionnaire was sent to 300 speech teachers in colleges and universities. Results were based on data obtained from 60 percent of the respondents. It was found that persuasion is taught in most colleges and universities, a wide range of…

  2. An Empirical Study of Relationships between Student Self-Concept and Science Achievement in Hong Kong

    ERIC Educational Resources Information Center

    Wang, Jianjun; Oliver, Steve; Garcia, Augustine

    2004-01-01

    Positive self-concept and good understanding of science are important indicators of scientific literacy endorsed by professional organizations. The existing research literature suggests that these two indicators are reciprocally related and mutually reinforcing. Generalization of the reciprocal model demands empirical studies in different…

  3. College Education and Attitudes toward Democracy in China: An Empirical Study

    ERIC Educational Resources Information Center

    Wang, Gang; Wu, Liyun; Han, Rongbin

    2015-01-01

    The modernization theory contends that there is a link between education and democracy. Yet few empirical studies have been done to investigate the role of higher education on promoting democratic values in the Chinese context. Using China General Social Survey 2006, this paper generates several findings which are not completely consistent with…

  4. Results from an Empirical Study of School Principals' Decisions about Disclosure of HIV Status

    ERIC Educational Resources Information Center

    Chenneville, Tiffany

    2007-01-01

    Elementary school principals' decisions about disclosure of school age children's confidential medical information was empirically studied. Participants included a stratified sample of 339 elementary school principals from the seven largest school districts in Florida. Each participant received one of six vignettes describing a student with HIV,…

  5. University-Industry Collaboration, Knowledge Management and Enterprise Innovation Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Chen, Jin; Wei, Shiyang

    2008-01-01

    This empirical study is concerned with university-industry collaboration from a knowledge management perspective. The authors introduce the concepts of "enterprise-level core elements" to define the principle status of an enterprise during university-industry collaboration, and "network embeddedness" as an indication of the closeness of the…

  6. An Empirical Study on the Acquisition of English Rising Tone by Chinese EFL Learners

    ERIC Educational Resources Information Center

    Chen, Wenkai

    2013-01-01

    Intonation is the melody and soul of speech, and plays an important role in oral communication. Nevertheless, the acquisition of English intonation by Chinese EFL learners is far from being satisfactory. It is found by empirical study that the main problems existing in acquiring English rising tone are improper placement of nucleus stress, failure…

  7. The Practicum in Preservice Teacher Education: A Review of Empirical Studies

    ERIC Educational Resources Information Center

    Cohen, Esther; Hoz, Ron; Kaplan, Haya

    2013-01-01

    This literature review presents a systematic analysis of 113 empirical studies conducted between 1996 and 2009, portraying a picture of the rationales, goals, activities, roles, and outcomes in the different practicum settings in teacher education programs. The review shows that the rationale, goals, and activities in the different practicum…

  8. Chinese Fantasy Novel: Empirical Study on New Word Teaching for Non-Native Learners

    ERIC Educational Resources Information Center

    Meng, Bok Check; Soon, Goh Ying

    2014-01-01

    Giving additional learning materials such as Chinese fantasy novel to non-native learners can be strenuous. This study seeks to render empirical support on the usefulness of the use of new words in Chinese fantasy novel to enhance vocabulary learning among the non-native learners of Chinese. In general, the students agreed that they like to learn…

  9. Requisite Skills of Entry-Level Programmers: An Empirical Study in Brunei Darussalam.

    ERIC Educational Resources Information Center

    Rahman, Mohd Noah A.; Rahim, M. Mahbubur; Seyal, Afzaal H.

    1999-01-01

    Reports the results of an empirical study in Brunei Darussalam that identified the types of skills required for entry-level computer programmers. Investigated whether skills were related to organizational size; determined that communications skills were the top requirement, followed by database management systems skills; and discovered a decline…

  10. Design Models as Emergent Features: An Empirical Study in Communication and Shared Mental Models in Instructional

    ERIC Educational Resources Information Center

    Botturi, Luca

    2006-01-01

    This paper reports the results of an empirical study that investigated the instructional design process of three teams involved in the development of an e-­learning unit. The teams declared they were using the same fast-­prototyping design and development model, and were composed of the same roles (although with a different number of SMEs).…

  11. An Empirical Case Study of a Child Sexual Abuse Prevention Initiative in Georgia

    ERIC Educational Resources Information Center

    Schober, Daniel J.; Fawcett, Stephen B.; Thigpen, Sally; Curtis, Anna; Wright, Renee

    2012-01-01

    Objective: This empirical case study describes Prevent Child Abuse Georgia's effort to prevent child sexual abuse (CSA) by educating communities throughout the state on supporting preventive behaviour. The initiative consisted of three major components: (1) dissemination of CSA prevention messages and materials; (2) a statewide helpline that…

  12. An Empirical Review of Research Methodologies and Methods in Creativity Studies (2003-2012)

    ERIC Educational Resources Information Center

    Long, Haiying

    2014-01-01

    Based on the data collected from 5 prestigious creativity journals, research methodologies and methods of 612 empirical studies on creativity, published between 2003 and 2012, were reviewed and compared to those in gifted education. Major findings included: (a) Creativity research was predominantly quantitative and psychometrics and experiment…

  13. An Empirical Study on the Effect of School Consolidation in Rural Areas on Student Achievement

    ERIC Educational Resources Information Center

    Mei, Dong; Fang, Chang; Yuanyan, Bai

    2013-01-01

    With Shaanxi province as an example, this study presents empirical evidence on the effect of primary school consolidation in rural areas on student achievement, using the difference-in-differences method. The results show no significant differences in student achievement between consolidated schools and nonconsolidated schools. If student…

  14. An Empirical Study Comparing the Effect of Feedback, Training and Executive Coaching on Leadership Behavior Change

    ERIC Educational Resources Information Center

    Saling, Nona

    2005-01-01

    Despite the phenomenal growth of executive coaching in recent years, there has been little empirical research on its effectiveness. Executive coaching is typically delivered with 360 degree feedback and training. This study tests whether there are significant differences in leadership behavior change for participants who: received feedback alone;…

  15. Empirical Studies on Software Notices to Inform Policy Makers and Usability Designers

    NASA Astrophysics Data System (ADS)

    Grossklags, Jens; Good, Nathan

    We evaluate the usability of End User License Agreements (EULAs) of popular consumer programs. Results from an empirical evaluation of 50 popular programs show the lack of accessibility and readability of notices. Our data from a recent study with 64 users involved in installation tasks confirms the public perception that notice to and consent by the user is not achieved.

  16. An Empirical Study of the Influence of the Concept of "Job-Hunting" on Graduates' Employment

    ERIC Educational Resources Information Center

    Chen, Chengwen; Hu, Guiying

    2008-01-01

    The concept of job-hunting is an important factor affecting university students' employment. This empirical study shows that while hunting for a job, graduates witness negative correlation between their expectation of the nature of work and the demand for occupational types and the accessibility to a post and monthly income; positive correlation…

  17. Analogical Scaffolding and the Learning of Abstract Ideas in Physics: Empirical Studies

    ERIC Educational Resources Information Center

    Podolefsky, Noah S.; Finkelstein, Noah D.

    2007-01-01

    Previously, we proposed a model of student reasoning which combines the roles of representation, analogy, and layering of meaning--analogical scaffolding [Podolefsky and Finkelstein, Phys. Rev. ST Phys. Educ. Res. 3, 010109 (2007)]. The present empirical studies build on this model to examine its utility and demonstrate the vital intertwining of…

  18. An Empirical Study of the Relative Error Magnitude in Three Measures of Change.

    ERIC Educational Resources Information Center

    Williams, Richard H.; And Others

    1984-01-01

    This paper describes the procedures and results of two studies designed to yield empirical comparisons of the error magnitude in three change measures: the simple gain score, the residualized difference score, and the base free measure (Tucker et al). Residualized scores possessed smaller standard errors of measurement. (Author/BS)

  19. Is Sustainability Possible? A Review and Commentary on Empirical Studies of Program Sustainability

    ERIC Educational Resources Information Center

    Scheirer, Mary Ann

    2005-01-01

    An important final step in the life cycles of programs and their evaluation involves assessing new programs' or innovations' sustainability. This review and synthesis of 19 empirical studies of the sustainability of American and Canadian health-related programs examines the extent of sustainability achieved and summarizes factors contributing to…

  20. Performance-Based Service Quality Model: An Empirical Study on Japanese Universities

    ERIC Educational Resources Information Center

    Sultan, Parves; Wong, Ho

    2010-01-01

    Purpose: This paper aims to develop and empirically test the performance-based higher education service quality model. Design/methodology/approach: The study develops 67-item instrument for measuring performance-based service quality with a particular focus on the higher education sector. Scale reliability is confirmed using the Cronbach's alpha.…

  1. A Study of Service-Learning at Virginia Highlands Community College and Mountain Empire Community College.

    ERIC Educational Resources Information Center

    Hughes, Alice

    This qualitative study was conducted to explore student perceptions of service learning as well as the importance of service learning to community college students. Data were collected through interviews with 24 community college participants from Virginia Highlands Community College and Mountain Empire Community College, both in southwest…

  2. Prevalence of clinically and empirically defined talents and strengths in autism.

    PubMed

    Meilleur, Andrée-Anne S; Jelenic, Patricia; Mottron, Laurent

    2015-05-01

    Outstanding skills, including special isolated skills (SIS) and perceptual peaks (PP) are frequent features of autism. However, their reported prevalence varies between studies and their co-occurrence is unknown. We determined the prevalence of SIS in a large group of 254 autistic individuals and searched for PP in 46 of these autistic individuals and 46 intelligence and age-matched typically developing controls. The prevalence of SIS among autistic individuals was 62.5% and that of PP was 58% (13% in controls). The prevalence of SIS increased with intelligence and age. The existence of an SIS in a particular modality was not associated with the presence of a PP in the same modality. This suggests that talents involve an experience-dependent component in addition to genetically defined alterations of perceptual encoding. PMID:25374134

  3. Hyperventilation in Panic Disorder and Asthma: Empirical Evidence and Clinical Strategies

    PubMed Central

    Meuret, Alicia E.; Ritz, Thomas

    2010-01-01

    Sustained or spontaneous hyperventilation has been associated with a variety of physical symptoms and has been linked to a number of organic illnesses and mental disorders. Theories of panic disorder hold that hyperventilation either produces feared symptoms of hypocapnia or protects against feared suffocation symptoms of hypercapnia. Although the evidence for both theories is inconclusive, findings from observational, experimental, and therapeutic studies suggest an important role of low carbon dioxide (CO2) levels in this disorder. Similarly, hypocapnia and associated hyperpnia are linked to bronchoconstriction, symptom exacerbation, and lower quality of life in patients with asthma. Raising CO2 levels by means of therapeutic capnometry has proven beneficial effects in both disorders, and the reversing of hyperventilation has emerged as a potent mediator for reductions in panic symptom severity and treatment success. PMID:20685222

  4. Universal protocol for alopecia areata clinical studies.

    PubMed

    Mesinkovska, Natasha A; Bergfeld, Wilma F

    2013-12-01

    Within the area of alopecia areata research, there is an obvious need for well-designed clinical trials of therapeutic agents. The National Alopecia Areata Foundation (NAAF) has created an initiative for the development of a unified protocol with guidelines for clinical studies. The NAAF universal protocol represents a joint effort of clinicians and investigators with experience in treating alopecia areata. This protocol will serve as a tremendous resource to facilitate future clinical studies. PMID:24326554

  5. [A Critical Condition of Clinical Studies in Japan -- A Battle of Clinical Study Groups].

    PubMed

    Furukawa, Hiroshi

    2016-04-01

    The post-marketing clinical study groups have been losing their activity due to stop of financial support. As the result, clinical study groups cannot achieve any EBM for treatment guidelines. Financial supports should be restarted immediately not to extinguish the post-marketing clinical studies and study groups. PMID:27220798

  6. Understanding clinical nursing education: An exploratory study.

    PubMed

    Dahlke, Sherry; O'Connor, Maureen; Hannesson, Teresa; Cheetham, Karleen

    2016-03-01

    Clinical experiences are recognized as a critical aspect of nursing education, highlighting the importance of the perspectives of those providing clinical instruction. The aim of this mixed methods descriptive study was to discover the knowledge and guidance needs of preceptors and clinical faculty who provide clinical instruction to Bachelor of Science in Nursing (BSN) students. Fifteen clinical faculty and 17 preceptors were surveyed using a questionnaire developed and piloted by the researchers. Although preceptors and clinical faculty reported a high level of knowledge and confidence in their ability to guide student nurses, they also identified the need for additional support for their teaching roles. Analysis of the qualitative data provided insights into what helped and what hindered clinical instruction, as well as what could enhance clinical instruction. The development, implementation, and evaluation of formal education and mentorship processes for preceptors and clinical faculty are recommended in order to meet these knowledge and guidance gaps. Further research is also needed to explore how to clinical instruction could be tailored to the capacity of those engaged in the experiences and to clinical environments. PMID:26775165

  7. Empirical Correlates of Low Scores on MMPI-2/MMPI-2-RF Restructured Clinical Scales in a Sample of University Students

    ERIC Educational Resources Information Center

    Avdeyeva, Tatyana V.; Tellegen, Auke; Ben-Porath, Yossef S.

    2012-01-01

    In the present study, the authors explored the meaning of low scores on the MMPI-2/MMPI-2-RF Restructured Clinical (RC) scales. Using responses of a sample of university students (N = 811), the authors examined whether low (T less than 39), within-normal-limits (T = 39-64), and high (T greater than 65) score levels on the RC scales are…

  8. Now or Later?: An Empirical Investigation of When and Why Students Apply to Clinical Psychology PhD Programs

    ERIC Educational Resources Information Center

    Zimak, Eric H.; Edwards, Katie M.; Johnson, Shannon M.; Suhr, Julie

    2011-01-01

    This study used a national sample of PhD students in clinical psychology (N = 1,034) to explore when students decided to pursue their graduate degree, reasons for their decisions, and associated satisfaction. Results indicated that immediately after completing their undergraduate degree, 57% of current graduate students reported postponing…

  9. Demonstrating Patterns in the Views Of Stakeholders Regarding Ethically-Salient Issues in Clinical Research: A Novel Use of Graphical Models in Empirical Ethics Inquiry

    PubMed Central

    Kim, Jane Paik; Roberts, Laura Weiss

    2015-01-01

    Background Empirical ethics inquiry works from the notion that stakeholder perspectives are necessary for gauging the ethical acceptability of human studies and assuring that research aligns with societal expectations. Although common, studies involving different populations often entail comparisons of trends that problematize the interpretation of results. Using graphical model selection – a technique aimed at transcending limitations of conventional methods – this report presents data on the ethics of clinical research with two objectives: (1) to display the patterns of views held by ill and healthy individuals in clinical research as a test of the study’s original hypothesis and (2) to introduce graphical model selection as a key analytic tool for ethics research. Methods In this IRB-approved, NIH-funded project, data were collected from 60 mentally ill and 43 physically ill clinical research protocol volunteers, 47 healthy protocol-consented participants, and 29 healthy individuals without research protocol experience. Respondents were queried on the ethical acceptability of research involving people with mental and physical illness (i.e., cancer, HIV, depression, schizophrenia, and post-traumatic stress disorder) and non-illness related sources of vulnerability (e.g., age, class, gender, ethnicity). Using a statistical algorithm, we selected graphical models to display interrelationships among responses to questions. Results Both mentally and physically ill protocol volunteers revealed a high degree of connectivity among ethically-salient perspectives. Healthy participants, irrespective of research protocol experience, revealed patterns of views that were not highly connected. Conclusion Between ill and healthy protocol participants, the pattern of views is vastly different. Experience with illness was tied to dense connectivity, whereas healthy individuals expressed views with sparse connections. In offering a nuanced perspective on the interrelation of

  10. Hebephilia as mental disorder? A historical, cross-cultural, sociological, cross-species, non-clinical empirical, and evolutionary review.

    PubMed

    Rind, Bruce; Yuill, Richard

    2012-08-01

    Blanchard et al. (2009) demonstrated that hebephilia is a genuine sexual preference, but then proposed, without argument or evidence, that it should be designated as a mental disorder in the DSM-5. A series of Letters-to-the-Editor criticized this proposal as a non sequitur. Blanchard (2009), in rebuttal, reaffirmed his position, but without adequately addressing some central criticisms. In this article, we examine hebephilia-as-disorder in full detail. Unlike Blanchard et al., we discuss definitions of mental disorder, examine extensive evidence from a broad range of sources, and consider alternative (i.e., non-pathological) explanations for hebephilia. We employed Wakefield's (1992b) harmful dysfunction approach to disorder, which holds that a condition only counts as a disorder when it is a failure of a naturally selected mechanism to function as designed, which is harmful to the individual in the current environment. We also considered a harmful-for-others approach to disorder (Brülde, 2007). Examination of historical, cross-cultural, sociological, cross-species, non-clinical empirical, and evolutionary evidence and perspectives indicated that hebephilic interest is an evolved capacity and hebephilic preference an expectable distributional variant, both of which were adaptively neutral or functional, not dysfunctional, in earlier human environments. Hebephilia's conflict with modern society makes it an evolutionary mismatch, not a genuine disorder. Though it should not be classified as a disorder, it could be entered in the DSM's V-code [corrected] section, used for non-disordered conditions that create significant problems in present-day society. PMID:22739816

  11. Mental Health Nursing of Adults With Intellectual Disabilities and Mental Illness: A Review of Empirical Studies 1994-2013.

    PubMed

    Bakken, Trine Lise; Sageng, Heidi

    2016-04-01

    Mental health nursing for adults with intellectual disabilities and mental illness is underresearched. The aim of this review is to summarize empirical mental health nursing studies including adults with intellectual disabilities and additional mental illness. Out of 137 hits, 16 articles were reviewed in full text. Thirteen of the articles presented modified nursing interventions. Three articles discussed training and education. The main finding is that mental health nursing interventions in patients with intellectual disabilities and additional mental illness are in line with mental health nursing for the general population. There are still not many publications on empirical studies concerning mental health nursing for adults with intellectual disabilities. Clinical implications are primarily related to the need for facilitated nurse-patient communication adjusted to the patients' cognitive levels. Insights drawn from this review illuminate the importance of mental health nursing interventions adjusting to the particular patients' symptoms, instead of targeting behavior change. The findings underpin factors found to have a positive impact on patients with mental illness in the general population as relevant topics for future research. PMID:26992884

  12. Development of phonological awareness in Down syndrome: A meta-analysis and empirical study.

    PubMed

    Næss, Kari-Anne B

    2016-02-01

    Phonological awareness (PA) is the knowledge and understanding of the sound structure of language and is believed to be an important skill for the development of reading. This study explored PA skills in children with Down syndrome and matched typically developing (TD) controls using a dual approach: a meta-analysis of the existing international literature and a longitudinal empirical study. The results from both the meta-analysis and the empirical study showed that the children with Down syndrome initially had weaker PA skills compared to the controls; in particular, the awareness of rhyme was delayed. The longitudinal empirical data indicated that, as a result of formal education, the children with Down syndrome exhibited greater improvement on all PA measures compared with the controls who had not yet entered school. The results reach significance for rhyme awareness. With respect to dimensionality, the performance of the children with Down syndrome loaded on 1 factor, whereas the performance of the younger TD controls was multidimensional. In sum, these findings underline the need for studies that compare interventions designed especially to stimulate development of PA in this group of children and to provide insight into the underlying causes of the developmental profile of children with Down syndrome. PMID:26689762

  13. Semi-Empirical Study of the Indirect Exchange Interaction in the Rem - Al System

    NASA Astrophysics Data System (ADS)

    Shakarov, Kh. O.

    2016-05-01

    The Ruderman-Kittel-Kasuya-Yosida exchange interaction (RKKY) is semi-empirically studied for the first time in compounds of binary REM - Al systems (REM - rare-earth metals: Gd, Dy, Ho, Er) using experimental values of paramagnetic Curie point (θp) of these compounds. Prediction of the RKKY theory was confirmed, i.e. there is a direct proportional dependence of θp value on de Gennes factor for equiatomic compounds of heavy REM with aluminum, just as in the case of pure REM. Values of the indirect exchange interaction parameter were semi-empirically estimated for the studied compounds. In general, it was established that RKKY-type exchange interaction is typical for REM compounds with aluminum, just as for pure REM.

  14. Clinical Applications of Evaluation Studies.

    ERIC Educational Resources Information Center

    Brown, Barry S.

    A series of followup investigations exploring the impact of methadone maintenance treatment, methadone detoxification treatment, therapeutic communities, and outpatient drug-free treatment for the drug abuser was conducted. Limitations of these modalities were revealed in the followup studies. Implications for treatment and policy include: (1)…

  15. Empirical study on structural properties in temporal networks under different time scales

    NASA Astrophysics Data System (ADS)

    Chen, Duanbing

    2015-12-01

    Many network analyzing methods are usually based on static networks. However, temporal networks should be considered so as to investigate real complex systems deeply since some dynamics on these systems cannot be described by static networks accurately. In this paper, four structural properties in temporal networks are empirically studied, including degree, clustering coefficient, adjacent correlation, and connected component. Three real temporal networks with different time scales are analyzed in this paper, including short message, telephone, and router networks. Moreover, structural properties of these temporal networks are compared with that of corresponding static aggregation networks in the whole time window. Some essential differences of structural properties between temporal and static networks are achieved through empirical analysis. Finally, the effect of structural properties on spreading dynamics under different time scales is investigated. Some interesting results such as turning point of structure evolving time scale corresponding to certain spreading dynamics time scale from the point of view of infected scale are achieved.

  16. Applications of the PM3 semi-empirical method to the study of triethylenediamine.

    PubMed

    Mancuso, J; McEachern, R J

    1997-04-01

    Charcoal filters impregnated with triethylenediamine (TEDA) are known to be efficient for the collection of volatile methyl iodide, which may be released under a hypothetical loss-of-coolant accident in a nuclear generating station. The structure and thermodynamic stability of the products of the TEDA-methyl iodide reaction have thus been studied using semi-empirical techniques. The reaction of TEDA with two molecules of methyl iodide leads to a quaternization reaction at each of the nitrogens. Moreover, it is shown that substitution of the hydrogens on TEDA with electron-donating groups can lead to enhanced stability of the quaternary ammonium reaction products. The semi-empirical method PM3 (Parametric Method 3) was used as the basis for all calculations. Molecular systems and simulations were constructed using HyperChem 4.5 for Silicon Graphics workstations. Enthalpy determination and geometry optimization were some of the calculations performed on a system. PMID:9385556

  17. Effects of Mindfulness on Psychological Health: A Review of Empirical Studies

    PubMed Central

    Keng, Shian-Ling; Smoski, Moria J.; Robins, Clive J.

    2013-01-01

    Within the past few decades, there has been a surge of interest in the investigation of mindfulness as a psychological construct and as a form of clinical intervention. This article reviews the empirical literature on the effects of mindfulness on psychological health. We begin with a discussion of the construct of mindfulness, differences between Buddhist and Western psychological conceptualizations of mindfulness, and how mindfulness has been integrated into Western medicine and psychology, before reviewing three areas of empirical research: cross-sectional, correlational research on the associations between mindfulness and various indicators of psychological health; intervention research on the effects of mindfulness-oriented interventions on psychological health; and laboratory-based, experimental research on the immediate effects of mindfulness inductions on emotional and behavioral functioning. We conclude that mindfulness brings about various positive psychological effects, including increased subjective well-being, reduced psychological symptoms and emotional reactivity, and improved behavioral regulation. The review ends with a discussion on mechanisms of change of mindfulness interventions and suggested directions for future research. PMID:21802619

  18. Empiric broad-spectrum antibiotic therapy of nosocomial pneumonia in the intensive care unit: a prospective observational study

    PubMed Central

    Álvarez-Lerma, Francisco; Alvarez, Bernabe; Luque, Pilar; Ruiz, Francisco; Dominguez-Roldan, Jose-Maria; Quintana, Elisabet; Sanz-Rodriguez, Cesar

    2006-01-01

    Introduction Antibiotic de-escalation, which consists of the initial institution of empiric broad-spectrum antibiotics followed by antibiotic streamlining driven by microbiological documentation, is thought to provide maximum benefit for the individual patient, while reducing the selection pressure for resistance. Methods To assess a carbapenem-based de-escalating strategy in nosocomial pneumonia (NP), a prospective observational study was conducted in critically ill patients with NP treated empirically with imipenem ± aminoglycoside/glycopeptide in 24 intensive care units of Spanish general hospitals. Overall, 244 patients were assessable (91% with late-onset NP). The primary outcome was therapeutic success 7–9 days post therapy. Results Microbial identification – based on cultures of tracheal aspirates in 82% of patients, cultures of protected specimen brush in 33%, and cultures of bronchoalveolar lavage in 4% – was only available for 131 (54%) patients. Initial antibiotics were inadequate for 23 (9%) patients. Of the remaining patients, antibiotics were streamlined in 56 (23%) patients and remained unchanged in 14 (6%) patients based on microbiology data, in 38 (16%) patients despite microbiology data favouring de-escalation, and in 113 (46%) patients due to unknown aetiology. Overall, de-escalation was implemented in only 23% of patients with potentially multiresistant pathogens, compared with 68% of patients with the remaining pathogens (P < 0.001). Response rates were 53% for patients continuously treated with imipenem-based regimens and 50% for the de-escalated patients. Higher Acute Physiology, Age, and Chronic Health Evaluation II scores were associated with greater mortality, whereas adequate empiric antibiotic therapy protected against fatal outcomes. No increase of superinfection rates caused by emerging pathogens was observed. The costs associated with de-escalation were mainly dependent on the duration of hospitalization. Conclusion This study

  19. Evidence for the Effectiveness of Jungian Psychotherapy: A Review of Empirical Studies

    PubMed Central

    Roesler, Christian

    2013-01-01

    Since the 1990s several research projects and empirical studies (process and outcome) on Jungian Psychotherapy have been conducted mainly in Germany and Switzerland. Prospective, naturalistic outcome studies and retrospective studies using standardized instruments and health insurance data as well as several qualitative studies of aspects of the psychotherapeutic process will be summarized. The studies are diligently designed and the results are well applicable to the conditions of outpatient practice. All the studies show significant improvements not only on the level of symptoms and interpersonal problems, but also on the level of personality structure and in every day life conduct. These improvements remain stable after completion of therapy over a period of up to six years. Several studies show further improvements after the end of therapy, an effect which psychoanalysis has always claimed. Health insurance data show that, after Jungian therapy, patients reduce health care utilization to a level even below the average of the total population. Results of several studies show that Jungian treatment moves patients from a level of severe symptoms to a level where one can speak of psychological health. These significant changes are reached by Jungian therapy with an average of 90 sessions, which makes Jungian psychotherapy an effective and cost-effective method. Process studies support Jungian theories on psychodynamics and elements of change in the therapeutic process. So finally, Jungian psychotherapy has reached the point where it can be called an empirically proven, effective method. PMID:25379256

  20. Scaling up explanation generation: Large-scale knowledge bases and empirical studies

    SciTech Connect

    Lester, J.C.; Porter, B.W.

    1996-12-31

    To explain complex phenomena, an explanation system must be able to select information from a formal representation of domain knowledge, organize the selected information into multisentential discourse plans, and realize the discourse plans in text. Although recent years have witnessed significant progress in the development of sophisticated computational mechanisms for explanation, empirical results have been limited. This paper reports on a seven year effort to empirically study explanation generation from semantically rich, large-scale knowledge bases. We first describe Knight, a robust explanation system that constructs multi-sentential and multi-paragraph explanations from the Biology Knowledge Base, a large-scale knowledge base in the domain of botanical anatomy, physiology, and development. We then introduce the Two Panel evaluation methodology and describe how Knight`s performance was assessed with this methodology in the most extensive empirical evaluation conducted on an explanation system. In this evaluation, Knight scored within {open_quotes}half a grade{close_quote} of domain experts, and its performance exceeded that of one of the domain experts.

  1. Empirical Research and Geography Teaching. Nederlandse Geografische Studies 142 (Netherlands Geographical Studies 142).

    ERIC Educational Resources Information Center

    Schrettenbrunner, H., Ed.; Westrhenen, J. van, Ed.

    This volume contains 10 articles that concern research efforts undertaken in the field of geography education and training. Written by researchers from around the world, the articles include: (1) "Empirical Didactics of Geography: History of a Working Group" (H. Schrettenbrunner); (2) "The Development and Evaluation of a Geography Computer…

  2. How fast is fisheries-induced evolution? Quantitative analysis of modelling and empirical studies

    PubMed Central

    Audzijonyte, Asta; Kuparinen, Anna; Fulton, Elizabeth A

    2013-01-01

    A number of theoretical models, experimental studies and time-series studies of wild fish have explored the presence and magnitude of fisheries-induced evolution (FIE). While most studies agree that FIE is likely to be happening in many fished stocks, there are disagreements about its rates and implications for stock viability. To address these disagreements in a quantitative manner, we conducted a meta-analysis of FIE rates reported in theoretical and empirical studies. We discovered that rates of phenotypic change observed in wild fish are about four times higher than the evolutionary rates reported in modelling studies, but correlation between the rate of change and instantaneous fishing mortality (F) was very similar in the two types of studies. Mixed-model analyses showed that in the modelling studies traits associated with reproductive investment and growth evolved slower than rates related to maturation. In empirical observations age-at-maturation was changing faster than other life-history traits. We also found that, despite different assumption and modelling approaches, rates of evolution for a given F value reported in 10 of 13 modelling studies were not significantly different. PMID:23789026

  3. Relating clinical study design to basic research.

    PubMed

    Choh, V; Priolo, S

    1999-07-01

    Devising any research study involves careful attention to its design, as well as the development of an appropriate research question and hypothesis. Together, these attributes ensure the validity of the study in question. In most clinical or epidemiological studies, the types of research designs are often explicitly noted, whereas in papers describing basic or biological research, they are couched in different terms or, more often, are ignored, thus potentially hindering communication between basic and clinical researchers. However, given that the framework for all valid scientific research is based on sound logic, it is proposed that for each study design, a direct homology exists between clinical and basic research paradigms, despite the problem of relating epidemiological vernacular to basic research. By applying examples of basic research protocols to traditional clinical study designs, this paper shows that parallels can be drawn between the two strategies, suggesting that in the absence of a conventional nomenclature to describe basic research study designs, the use of traditional clinical design jargon is valid in describing basic research protocols. PMID:10445637

  4. The Clinical Outcome Study for dysferlinopathy

    PubMed Central

    Harris, Elizabeth; Bladen, Catherine L.; Mayhew, Anna; James, Meredith; Bettinson, Karen; Moore, Ursula; Smith, Fiona E.; Rufibach, Laura; Cnaan, Avital; Bharucha-Goebel, Diana X.; Blamire, Andrew M.; Bravver, Elena; Carlier, Pierre G.; Day, John W.; Díaz-Manera, Jordi; Eagle, Michelle; Grieben, Ulrike; Harms, Matthew; Jones, Kristi J.; Lochmüller, Hanns; Mendell, Jerry R.; Mori-Yoshimura, Madoka; Paradas, Carmen; Pegoraro, Elena; Pestronk, Alan; Salort-Campana, Emmanuelle; Schreiber-Katz, Olivia; Semplicini, Claudio; Spuler, Simone; Stojkovic, Tanya; Straub, Volker; Takeda, Shin'ich; Rocha, Carolina Tesi; Walter, M.C.

    2016-01-01

    Objective: To describe the baseline clinical and functional characteristics of an international cohort of 193 patients with dysferlinopathy. Methods: The Clinical Outcome Study for dysferlinopathy (COS) is an international multicenter study of this disease, evaluating patients with genetically confirmed dysferlinopathy over 3 years. We present a cross-sectional analysis of 193 patients derived from their baseline clinical and functional assessments. Results: There is a high degree of variability in disease onset, pattern of weakness, and rate of progression. No factor, such as mutation class, protein expression, or age at onset, accounted for this variability. Among patients with clinical diagnoses of Miyoshi myopathy or limb-girdle muscular dystrophy, clinical presentation and examination was not strikingly different. Respiratory impairment and cardiac dysfunction were observed in a minority of patients. A substantial delay in diagnosis was previously common but has been steadily reducing, suggesting increasing awareness of dysferlinopathies. Conclusions: These findings highlight crucial issues to be addressed for both optimizing clinical care and planning therapeutic trials in dysferlinopathy. This ongoing longitudinal study will provide an opportunity to further understand patterns and variability in disease progression and form the basis for trial design. PMID:27602406

  5. Penile dermatoses: a clinical and histopathological study.

    PubMed Central

    Hillman, R J; Walker, M M; Harris, J R; Taylor-Robinson, D

    1992-01-01

    OBJECTIVE--To assess the spectrum of genital dermatological conditions affecting men and compare the clinical and histopathological diagnoses. DESIGN--Prospective study over a one year period. SETTING--A central London teaching hospital. PATIENTS--Seventy one patients with unresponsive penile dermatoses attending a specific internal referral clinic within the department of genitourinary medicine and 36 patients undergoing penile biopsy following attendance at other departments within the same hospital. METHODS--Full dermatological assessment of patients attending the specific clinic. Standard histopathological methods were used in the diagnosis of biopsy specimens. OUTCOME MEASURED--Clinico-pathological diagnosis of cutaneous penile abnormalities. RESULTS--Description of the range and relative frequency of penile dermatological conditions. The most common histopathological diagnosis was of non specific dermatitis. Twenty seven percent (16 of 61) of patients attending the specific clinic and 33% (12 of 36) of men attending other departments had conditions requiring long term follow up. CONCLUSIONS--The ranges of penile dermatoses presenting to the different departments were broadly similar. Penile biopsy was shown to be a safe and clinically informative procedure. In the genitourinary clinic setting, clinical diagnosis prior to biopsy was found frequently to be inaccurate. Images PMID:1607192

  6. Clarithromycin vs. Gemifloxacin in Quadruple Therapy Regimens for Empiric Primary Treatment of Helicobacter pylori Infection: A Randomized Clinical Trial

    PubMed Central

    Masoodi, Mohsen; Talebi-Taher, Mahshid; Tabatabaie, Khadijeh; Khaleghi, Siamak; Faghihi, Amir-Hossein; Agah, Shahram; Asadi, Reyhaneh

    2015-01-01

    BACKGROUND Eradication of Helicobacter pylori infection plays a crucial role in the treatment of peptic ulcer. Clarithromycin resistance is a major cause of treatment failure. This randomized clinical trial aimed at evaluating the efficacy of a clarithromycin versus gemifloxacin containing quadruple therapy regimen in eradication of H.pylori infection. METHODS In this randomized double blind clinical trial (RCT 2012102011054N2), a total of 120 patients were randomized to two groups of 60 patients each. Patients with proven H.pylori infection were consecutively assigned into two groups to receive OBAG or OBAC in gastroenterology clinic in Rasoul-e- Akram General Hospital in Tehran, Iran. The patients in the OBAG group received omeprazole (20 mg) twice daily, bismuth subcitrate (240 mg) twice daily, amoxicillin (1 gr) twice daily, and gemifloxacin (320 mg) once daily, and those in the OBAC group received omeprazole (20 mg) twice daily, 240 mg of bismuth subcitrate twice daily, amoxicillin (1 gr) twice daily, and clarithromycin (500 mg) twice daily for 10 days. RESULTS Five patients from each group were excluded from the study because of poor compliance, so 110 patients completed the study. The intention-to-treat eradication rate was 61.6% and 66.6% for the OBAC and OBAG groups, respectively. According to the per protocol analysis, the success rates of eradication of H.pylori infection were 67.2% and 72.7% for OBAC and OBAG groups, respectively (p=0.568). CONCLUSION The results of this study suggest that gemifloxacin containing regimen is at least as effective as clarithromycin regimen; hence, this new treatment could be considered as an alternative for the patients who cannot tolerate clarithromycin. PMID:26106468

  7. Embedding clinical interventions into observational studies.

    PubMed

    Newman, Anne B; Avilés-Santa, M Larissa; Anderson, Garnet; Heiss, Gerardo; Howard, Wm James; Krucoff, Mitchell; Kuller, Lewis H; Lewis, Cora E; Robinson, Jennifer G; Taylor, Herman; Treviño, Roberto P; Weintraub, William

    2016-01-01

    Novel approaches to observational studies and clinical trials could improve the cost-effectiveness and speed of translation of research. Hybrid designs that combine elements of clinical trials with observational registries or cohort studies should be considered as part of a long-term strategy to transform clinical trials and epidemiology, adapting to the opportunities of big data and the challenges of constrained budgets. Important considerations include study aims, timing, breadth and depth of the existing infrastructure that can be leveraged, participant burden, likely participation rate and available sample size in the cohort, required sample size for the trial, and investigator expertise. Community engagement and stakeholder (including study participants) support are essential for these efforts to succeed. PMID:26611435

  8. Linking customisation of ERP systems to support effort: an empirical study

    NASA Astrophysics Data System (ADS)

    Koch, Stefan; Mitteregger, Kurt

    2016-01-01

    The amount of customisation to an enterprise resource planning (ERP) system has always been a major concern in the context of the implementation. This article focuses on the phase of maintenance and presents an empirical study about the relationship between the amount of customising and the resulting support effort. We establish a structural equation modelling model that explains support effort using customisation effort, organisational characteristics and scope of implementation. The findings using data from an ERP provider show that there is a statistically significant effect: with an increasing amount of customisation, the quantity of telephone calls to support increases, as well as the duration of each call.

  9. PPB | What is a Clinical Study

    Cancer.gov

    The Pleuropulmonary blastoma (PPB) DICER1 Syndrome Study ‹an observational clinical research study‹is enrolling children with PPB and their families. In an observational study, investigators assess health outcomes in groups of participants according to a protocol or research plan.

  10. Does Branding Need Web Usability? A Value-Oriented Empirical Study

    NASA Astrophysics Data System (ADS)

    Bolchini, Davide; Garzotto, Franca; Sorce, Fabio

    Does usability of a web-based communication artifact affect brand, i.e., the set of beliefs, emotions, attitudes, or qualities that people mentally associate to the entity behind that artifact? Intuitively, the answer is “yes”: usability is a fundamental aspect of the quality of the experience with a website, and a “good” experience with a “product” or its reifications tends to translate into “good” brand perception. To date, however, the existence of a connection between web usability and brand perception is shown through anecdotic arguments, and is not supported by published systematic research. This paper discusses a study that empirically investigates this correlation in a more rigorous, analytical, and replicable way. Our main contribution is twofold: on the one hand, we provide empirical evidence to the heuristic principle that web usability influences branding, and we do that through four between subjects controlled experiments that involved 120 subjects. On the other hand, we inform the study with a systematic value-oriented approach to the user experience, and thus provide a conceptual framework that can be reused in other experimental settings, either for replicating our study, or for designing similar studies focusing on the correlation of web branding vs. design factors other than usability.

  11. Empirically Derived Combinations of Tools and Clinical Cutoffs: An Illustrative Case with a Sample of Culturally/Linguistically Diverse Children

    ERIC Educational Resources Information Center

    Oetting, Janna B.; Cleveland, Lesli H.; Cope, Robert F., III

    2008-01-01

    Purpose: Using a sample of culturally/linguistically diverse children, we present data to illustrate the value of empirically derived combinations of tools and cutoffs for determining eligibility in child language impairment. Method: Data were from 95 4- and 6-year-olds (40 African American, 55 White; 18 with language impairment, 77 without) who…

  12. Impact of Company Size on Manufacturing Improvement Practices: An empirical study

    NASA Astrophysics Data System (ADS)

    Syan, C. S.; Ramoutar, K.

    2014-07-01

    There is a constant search for ways to achieve a competitive advantage through new manufacturing techniques. Best performing manufacturing companies tend to use world-class manufacturing (WCM) practices. Although the last few years have witnessed phenomenal growth in the use of WCM techniques, their effectiveness is not well understood specifically in the context of less developed countries. This paper presents an empirical study to investigate the impact of company size on improving manufacturing performance in manufacturing organizations based in Trinidad and Tobago (T&T). Empirical data were collected via a questionnaire survey which was send to 218 manufacturing firms in T&T. Five different company sizes and seven different industry sectors were studied. The analysis of survey data was performed with the aid of Statistical Package for Social Sciences (SPSS) software. The study signified facilitating and impeding factors towards improving manufacturing performance. Their relative impact/importance is dependent on varying company size and industry sectors. Findings indicate that T&T manufacturers are still practicing traditional approaches, when compared with world class manufacturers. In the majority of organizations, these practices were not 100% implemented even though they started the implementation process more than 5 years ago. The findings provided some insights in formulating more optimal operational strategies, and later develop action plans towards more effective implementation of WCM in T&T manufacturers.

  13. Advances in clinical study of curcumin.

    PubMed

    Yang, Chunfen; Su, Xun; Liu, Anchang; Zhang, Lin; Yu, Aihua; Xi, Yanwei; Zhai, Guangxi

    2013-01-01

    Curcumin has been estimated as a potential agent for many diseases and attracted great attention owing to its various pharmacological activities, including anti-cancer, and anti-inflammatory. Now curcumin is being applied to a number of patients with breast cancer, rheumatoid arthritis, Alzheimer's disease, colorectal cancer, psoriatic, etc. Several clinical trials have stated that curcumin is safe enough and effective. The objective of this article was to summarize the clinical studies of curcumin, and give a reference for future studies. PMID:23116307

  14. Marketing and clinical trials: a case study

    PubMed Central

    Francis, David; Roberts, Ian; Elbourne, Diana R; Shakur, Haleema; Knight, Rosemary C; Garcia, Jo; Snowdon, Claire; Entwistle, Vikki A; McDonald, Alison M; Grant, Adrian M; Campbell, Marion K

    2007-01-01

    Background Publicly funded clinical trials require a substantial commitment of time and money. To ensure that sufficient numbers of patients are recruited it is essential that they address important questions in a rigorous manner and are managed well, adopting effective marketing strategies. Methods Using methods of analysis drawn from management studies, this paper presents a structured assessment framework or reference model, derived from a case analysis of the MRC's CRASH trial, of 12 factors that may affect the success of the marketing and sales activities associated with clinical trials. Results The case study demonstrates that trials need various categories of people to buy in – hence, to be successful, trialists must embrace marketing strategies to some extent. Conclusion The performance of future clinical trials could be enhanced if trialists routinely considered these factors. PMID:18028537

  15. The performance of selected semi-empirical and DFT methods in studying C60 fullerene derivatives

    NASA Astrophysics Data System (ADS)

    Sikorska, Celina; Puzyn, Tomasz

    2015-11-01

    The capability of reproducing the open circuit voltages (V oc) of 15 representative C60 fullerene derivatives was tested using the selected quantum mechanical methods (B3LYP, PM6, and PM7) together with the two one-electron basis sets. Certain theoretical treatments (e.g. PM6) were found to be satisfactory for preliminary estimates of the open circuit voltages (V oc), whereas the use of the B3LYP/6-31G(d) approach has been proven to assure highly accurate results. We also examined the structural similarity of 19 fullerene derivatives by employing principle component analysis (PCA). In order to express the structural features of the studied compounds we used molecular descriptors calculated with semi-empirical (PM6 and PM7) and density functional (B3LYP/6-31G(d)) methods separately. In performing PCA, we noticed that semi-empirical methods (i.e. PM6 and PM7) seem satisfactory for molecules, in which one can distinguish the aromatic and the aliphatic parts in the cyclopropane ring of PCBM (phenyl-C61-buteric acid methyl ester) and they significantly overestimate the energy of the highest occupied molecular orbital (E HOMO). The use of the B3LYP functional, however, is recommended for studying methanofullerenes, which closely resemble the structure of PCBM, and for their modifications.

  16. Case Studies: Windows onto Clinical Supervision.

    ERIC Educational Resources Information Center

    Nolan, Jim; And Others

    1993-01-01

    By examining the structures and activities common to six case studies of clinical teacher supervision, this article identifies five conditions that facilitate changes in teacher thinking and behavior: development of a supportive, collegial relationship; teacher control over supervision products; continuity over time; focused, descriptive records…

  17. The relationship between corporate environmental performance and environmental disclosure: an empirical study in China.

    PubMed

    Meng, X H; Zeng, S X; Shi, Jonathan J; Qi, G Y; Zhang, Z B

    2014-12-01

    Based on a content analysis of 533 Chinese listed companies, this study examines how corporate environmental performance affects not only the level of detail of a company's environmental disclosures, but also what information is disclosed. The results show that (1) both poor and good performers have more disclosure than the median (i.e., "mixed") performers, which provides empirical evidence to support a nonlinear relationship between corporate environmental performance and environmental disclosure; (2) poor performers disclose more soft information on environmental performance than good performers, and good performers disclose more solid information; and (3) although poor performers increase disclosure after being exposed as environmental violators, they avoid disclosing negative environmental information, such as the violation and the associated penalties. This study provides additional evidence for a nonlinear relationship between environmental performance and disclosure in emerging markets, and suggests environmental disclosure may not be a valid signal to differentiate good performers from poor performers in contemporary China. PMID:25113230

  18. An Empirical Study of Synchrophasor Communication Delay in a Utility TCP/IP Network

    NASA Astrophysics Data System (ADS)

    Zhu, Kun; Chenine, Moustafa; Nordström, Lars; Holmström, Sture; Ericsson, Göran

    2013-07-01

    Although there is a plethora of literature dealing with Phasor Measurement Unit (PMU) communication delay, there has not been any effort made to generalize empirical delay results by identifying the distribution with the best fit. The existing studies typically assume a distribution or simply build on analogies to communication network routing delay. Specifically, this study provides insight into the characterization of the communication delay of both unprocessed PMU data and synchrophasors sorted by a Phasor Data Concentrator (PDC). The results suggest that a bi-modal distribution containing two normal distributions offers the best fit of the delay of the unprocessed data, whereas the delay profile of the sorted synchrophasors resembles a normal distribution based on these results, the possibility of evaluating the reliability of a synchrophasor application with respect to a particular choice of PDC timeout is discussed.

  19. Using multidimensional Rasch to enhance measurement precision: initial results from simulation and empirical studies.

    PubMed

    Mok, Magdalena Mo Ching; Xu, Kun

    2013-01-01

    This study aimed to explore the effect on measurement precision of multidimensional, as compared with unidimensional, Rasch measurement for constructing measures from multidimensional Likert-type scales. Many educational and psychological tests are multidimensional but common practice is to ignore correlations among the latent traits in these multidimensional scales in the measurement process. These practices may have serious validity and reliability implications. This study made use of both empirical data from 208,083 students, and simulated data simulated by 24 systematic combinations, each replicated 1000 times, of three conditions, namely, sample size, degree of dimensionality, and scale length to compare unidimensional and multidimensional approaches and to identify effects of sample size, dimensionality and scale length on measurement precision. Results showed that the multidimensional Rasch approach yielded more precise estimates than did unidimensional approach if the two dimensions were strongly correlated. The effect was more pronounced for long scales. PMID:23442326

  20. Meaning as a mission: a review of empirical studies on appraisals of war and peacekeeping experiences.

    PubMed

    Schok, Michaela L; Kleber, Rolf J; Elands, Martin; Weerts, Jos M P

    2008-03-01

    The aim of this article is to review the scientific literature on making sense of war and peacekeeping experiences, and it includes an analysis of empirical studies that examine appraisals of military deployment experiences among veterans. Veterans reported more positive than negative effects in the studies of this review. Furthermore, construing positive meaning from war and peacekeeping experiences, especially related to combat exposure or high perceived threat, is associated with better psychological adjustment. More insight on "normal" psychological processing of stressful and traumatic experiences is obtained when the concept of meaning is used in research. This perspective emphasizes the perception of individuals and focuses on beliefs and attitudes in making sense of threatening events instead of pathologizing the response to trauma. PMID:17532104

  1. Anterior temporal face patches: a meta-analysis and empirical study

    PubMed Central

    Von Der Heide, Rebecca J.; Skipper, Laura M.; Olson, Ingrid R.

    2013-01-01

    Evidence suggests the anterior temporal lobe (ATL) plays an important role in person identification and memory. In humans, neuroimaging studies of person memory report consistent activations in the ATL to famous and personally familiar faces and studies of patients report resection or damage of the ATL causes an associative prosopagnosia in which face perception is intact but face memory is compromised. In addition, high-resolution fMRI studies of non-human primates and electrophysiological studies of humans also suggest regions of the ventral ATL are sensitive to novel faces. The current study extends previous findings by investigating whether similar subregions in the dorsal, ventral, lateral, or polar aspects of the ATL are sensitive to personally familiar, famous, and novel faces. We present the results of two studies of person memory: a meta-analysis of existing fMRI studies and an empirical fMRI study using optimized imaging parameters. Both studies showed left-lateralized ATL activations to familiar individuals while novel faces activated the right ATL. Activations to famous faces were quite ventral, similar to what has been reported in previous high-resolution fMRI studies of non-human primates. These findings suggest that face memory-sensitive patches in the human ATL are in the ventral/polar ATL. PMID:23378834

  2. Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach

    PubMed Central

    Spencer, Amy V.; Cox, Angela; Lin, Wei‐Yu; Easton, Douglas F.; Michailidou, Kyriaki

    2016-01-01

    ABSTRACT There is a large amount of functional genetic data available, which can be used to inform fine‐mapping association studies (in diseases with well‐characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't available, then specifying a prior variance for the effect sizes is challenging. We propose both an empirical method to estimate this prior variance, and a coherent approach to using SNP‐level functional data, to inform the prior probability of causal association. Through simulation we show that when ranking SNPs by our empirical Bayes factor in a fine‐mapping study, the causal SNP rank is generally as high or higher than the rank using Bayes factors with other plausible values of the prior variance. Importantly, we also show that assigning SNP‐specific prior probabilities of association based on expert prior functional knowledge of the disease mechanism can lead to improved causal SNPs ranks compared to ranking with identical prior probabilities of association. We demonstrate the use of our methods by applying the methods to the fine mapping of the CASP8 region of chromosome 2 using genotype data from the Collaborative Oncological Gene‐Environment Study (COGS) Consortium. The data we analysed included approximately 46,000 breast cancer case and 43,000 healthy control samples. PMID:26833494

  3. Incorporating Functional Genomic Information in Genetic Association Studies Using an Empirical Bayes Approach.

    PubMed

    Spencer, Amy V; Cox, Angela; Lin, Wei-Yu; Easton, Douglas F; Michailidou, Kyriaki; Walters, Kevin

    2016-04-01

    There is a large amount of functional genetic data available, which can be used to inform fine-mapping association studies (in diseases with well-characterised disease pathways). Single nucleotide polymorphism (SNP) prioritization via Bayes factors is attractive because prior information can inform the effect size or the prior probability of causal association. This approach requires the specification of the effect size. If the information needed to estimate a priori the probability density for the effect sizes for causal SNPs in a genomic region isn't consistent or isn't available, then specifying a prior variance for the effect sizes is challenging. We propose both an empirical method to estimate this prior variance, and a coherent approach to using SNP-level functional data, to inform the prior probability of causal association. Through simulation we show that when ranking SNPs by our empirical Bayes factor in a fine-mapping study, the causal SNP rank is generally as high or higher than the rank using Bayes factors with other plausible values of the prior variance. Importantly, we also show that assigning SNP-specific prior probabilities of association based on expert prior functional knowledge of the disease mechanism can lead to improved causal SNPs ranks compared to ranking with identical prior probabilities of association. We demonstrate the use of our methods by applying the methods to the fine mapping of the CASP8 region of chromosome 2 using genotype data from the Collaborative Oncological Gene-Environment Study (COGS) Consortium. The data we analysed included approximately 46,000 breast cancer case and 43,000 healthy control samples. PMID:26833494

  4. Clinical TVA-based studies: a general review

    PubMed Central

    Habekost, Thomas

    2015-01-01

    In combination with whole report and partial report tasks, the theory of visual attention (TVA) can be used to estimate individual differences in five basic attentional parameters: the visual processing speed, the storage capacity of visual short-term memory, the perceptual threshold, the efficiency of top–down selectivity, and the spatial bias of attentional weighting. TVA-based assessment has been used in about 30 studies to investigate attentional deficits in a range of neurological and psychiatric conditions: (a) neglect and simultanagnosia, (b) reading disturbances, (c) aging and neurodegenerative diseases, and most recently (d) neurodevelopmental disorders. The article introduces TVA based assessment, discusses its methodology and psychometric properties, and reviews the progress made in each of the four research fields. The empirical results demonstrate the general usefulness of TVA-based assessment for many types of clinical neuropsychological research. The method’s most important qualities are cognitive specificity and theoretical grounding, but it is also characterized by good reliability and sensitivity to minor deficits. The review concludes by pointing to promising new areas for clinical TVA-based research. PMID:25852607

  5. Reversal of dental fluorosis: A clinical study

    PubMed Central

    Mehta, Dhaval N.; Shah, Jigna

    2013-01-01

    Aim: This study was conducted to evaluate the clinical reversal of dental fluorosis with various combinations of calcium, vitamin D3, and ascorbic acid, along with changes in levels of certain biochemical parameters concerned with dental fluorosis. The role of fluoride level of drinking water in the etiology of dental fluorosis and the prevalence of dental fluorosis in both dentitions and teeth were also assessed. Materials and Methods: A total number of 50 patients with clinical features of dental fluorosis without trauma and any adverse habits were selected. Of these, in 30 co-operative patients, estimation of water fluoride level and pretreatment and post-treatment serum and urine fluoride levels were done with ion selective electrode method. The selected 30 patients were divided into three groups, that is, group A, group B, and group C, and were given various combinations of medications like calcium with vitamin D3 supplements, ascorbic acid with vitamin D3 supplements, and chlorhexidine mouthwash (placebo) for three months, respectively. These 30 patients were assessed for any change in the clinical grading of dental fluorosis. Results: No change in clinical grading of dental fluorosis was noted. Considerable reduction in serum and urine fluoride levels was noted in both group A and group B patients. Dental fluorosis was noted in permanent teeth more commonly than deciduous teeth, and permanent maxillary central incisors had the highest prevalence rate. Conclusion: This study comprises only 30 patients with three months of follow-up. So, this sample of patients and duration of follow-up period are conclusive to observe changes in biochemical parameters but not sufficient to observe changes in clinical grading. PMID:23633850

  6. Comprehensive versus matched psychosocial treatment in the MTA study: conceptual and empirical issues.

    PubMed

    Wells, K C

    2001-03-01

    Addressed some factual inaccuracies and presented alternative positions on key issues raised in the article by Greene and Ablon (this issue) on the question, "What does the Multimodal Treatment Study (MTA) tell us about effective psychosocial treatment for attention deficit hyperactivity disorder (ADHD)?" The Greene and Ablon critique does not present for the reader's consideration the full range of findings from the MTA study, notably those most relevant to psychosocial treatment, and articulates a theoretical position that effective treatment requires matching treatment to children's assessed needs, an approach not taken in the MTA study. In this article, I present the full range of findings from the MTA study related to psychosocial treatment effects, correct the misperceptions that exist about the study based on limited reviews such as Greene and Ablon's, and review the empirical and experimental design issues that produced the decision by the MTA investigative team to study the effects of intensive, comprehensive psychosocial treatment. I argue that the questions asked by the MTA study about psychosocial treatment were important, relevant, and were addressed well in the MTA study design. PMID:11294072

  7. Personal influences on professional work: an empirical case study of B.F. Skinner.

    PubMed

    Demorest, A P; Siegel, P F

    1996-03-01

    This study addresses the hypothesis that individuals have characteristic ways of looking at the world that are revealed not only in their life story but also in their professional work. It seeks to provide the first empirical test of this hypothesis using systematic methods for data selection, interpretation, and matching, as applied to the case of B. F. Skinner. Using the salience identifier "primacy" (Alexander, 1990), Skinner's first research design and the first paragraph of his autobiography were selected for analysis. Adopting a personological approach to interpretation, "scripts" (Tomkins, 1987) were derived from these materials by blind and independent coders. A matching task (Allport, 1961) then indicated that the scripts derived from Skinner's work and life were substantially similar and significantly more similar than random pairs of scripts . A search through other autobiographical and professional writings by Skinner revealed that the elements of the discovered script appear recurrently in his imagery. PMID:8656317

  8. Showing Where To Go by Maps or Pictures: An Empirical Case Study at Subway Exits

    NASA Astrophysics Data System (ADS)

    Ishikawa, Toru; Yamazaki, Tetsuo

    This study empirically examined the effectiveness of different methods of presenting route information on a mobile navigation sysyem, for accurate and effortless orientation at subway exits. Specifically, it compared participants’ spatial orientation performance with pictures and maps, in relation to the levels of their spatial ability. Participants identified the directions toward the goals after coming onto the ground faster when viewing pictures than when viewing maps. Spatial orientation with maps was more difficult than that with pictures at exits where body rotation was necessary, especially for people with low mental-rotation ability. In contrast, pictures were equally effective for people with low and high mental-rotation ability. Reasons for the effectiveness of pictures and possibilities of using other presentation formats are discussed.

  9. Measuring the Storage and Retrieval of Knowledge Units: An Empirical Study Using MES

    NASA Astrophysics Data System (ADS)

    Justus, Selwyn; Iyakutti, K.

    Computer applications are smart that they require efficient storage and retrieval of data. Object-relational data models are the opted and the widely appreciable approach because of their power in object representation and relational retrieval. Two OR models were designed for representing knowledge units in the Music Expert System and three metrics were proposed to study the storage and retrieval of the knowledge units from the OR schemas. Experiments conducted to asses the storage efficiency and relational retrieval of the objects indicated significant results. The metrics were used to keep in check the size of the objects created during runtime and their relational coupling helped in the retrieval of objects, with minimal disk reads. The empirical results and interpretations concludes the work, focusing on the efficient design of OR schema models which commend the functioning of the system’s performance.

  10. The Association between Peace and Life Expectancy: An Empirical Study of the World Countries

    PubMed Central

    YAZDI FEYZABADI, Vahid; HAGHDOOST, Aliakbar; MEHROLHASSANI, Mohammad Hossein; AMINIAN, Zahra

    2015-01-01

    Background: Although theoretically peace affects health, few published evidence for such an association was empirically available. This study aimed to explore the association between peace and life expectancy (LE) among the world countries. Methods: In an ecological study and using random effects regression model, we examined the association between peace and LE among world countries between 2007 and 2012. The LE at birth and global peace index (GPI: a score between 1 and 5, higher score means lower peace) were selected as outcome and main predictor variables, respectively. We adjusted their association for the gross national income (GNI) per capita and education index (EI). Data were obtained from the Institute for Economics and Peace (IEP) and UNDP (United Nations Development Programme (UNDP). Numbers of included countries were 158 based on the available data. Results: GPI had a negative, considerable, and statistically significant effect on LE (standardized coefficient −0.039; 95% CI: −0.058, −0.019). This association was also significant even after the adjustment for EI (−0.019; 95% CI: −0.035, −0.003), GNI (−0.035; 95% CI: −0.055, −0.015), and both EI and GNI (−0.017; 95% CI: −0.033, −0.001). The full model showed that around 0.61 of the variation of LE among countries may be explained by the GPI, EI and GNI per capita. Conclusion: The contribution of peace as a global determinant of LE was empirically considerable even after the adjustment for the economic and education levels of countries. This implies that governments should make efforts to settle peace through implementing good governance based on interactions with both public and other countries. PMID:25905077

  11. Lessons Learned on Benchmarking from the International Human Reliability Analysis Empirical Study

    SciTech Connect

    Ronald L. Boring; John A. Forester; Andreas Bye; Vinh N. Dang; Erasmia Lois

    2010-06-01

    The International Human Reliability Analysis (HRA) Empirical Study is a comparative benchmark of the prediction of HRA methods to the performance of nuclear power plant crews in a control room simulator. There are a number of unique aspects to the present study that distinguish it from previous HRA benchmarks, most notably the emphasis on a method-to-data comparison instead of a method-to-method comparison. This paper reviews seven lessons learned about HRA benchmarking from conducting the study: (1) the dual purposes of the study afforded by joining another HRA study; (2) the importance of comparing not only quantitative but also qualitative aspects of HRA; (3) consideration of both negative and positive drivers on crew performance; (4) a relatively large sample size of crews; (5) the use of multiple methods and scenarios to provide a well-rounded view of HRA performance; (6) the importance of clearly defined human failure events; and (7) the use of a common comparison language to “translate” the results of different HRA methods. These seven lessons learned highlight how the present study can serve as a useful template for future benchmarking studies.

  12. Structural Patterns in Empirical Research Articles: A Cross-Disciplinary Study

    ERIC Educational Resources Information Center

    Lin, Ling; Evans, Stephen

    2012-01-01

    This paper presents an analysis of the major generic structures of empirical research articles (RAs), with a particular focus on disciplinary variation and the relationship between the adjacent sections in the introductory and concluding parts. The findings were derived from a close "manual" analysis of 433 recent empirical RAs from high-impact…

  13. An Empirical Study of the Range of Marital Complaints Found in the Areas of Change Questionnaire.

    ERIC Educational Resources Information Center

    Mead, D. Eugene; Vatcher, Gary

    1985-01-01

    Describes a study to determine if the Areas of Change Questionnaire (AC) items represent commonly occurring problems seen by marital therapists and identified by Geiss and O'Leary (1981). Results suggest that AC Questionnaire, containing 13 of Geiss and O'Leary's 29 marital problem categories, is limited in the range of clinical marital problems…

  14. Lessons with Living Harvest Mice: An Empirical Study of Their Effects on Intrinsic Motivation and Knowledge Acquisition

    ERIC Educational Resources Information Center

    Wilde, Matthias; Hubmann, Jona Samuel; Lorenzen, Simone; Meyer, Annika; Randler, Christoph

    2012-01-01

    The aim of this study was to evaluate the effects of living animals on pupils' intrinsic motivation and knowledge. Various studies from the late 1970s and 1980s stress the high effectiveness of authentic learning experiences in pupils' knowledge acquisition. However, there are only few current empirical studies on this topic. The research question…

  15. Think-Aloud Protocols in Research on Essay Rating: An Empirical Study of Their Veridicality and Reactivity

    ERIC Educational Resources Information Center

    Barkaoui, Khaled

    2011-01-01

    Think-aloud protocols (TAPs) are frequently used in research on essay rating processes. However, there are very few empirical studies of the completeness of TAP data and the effects of this technique on rater performance (i.e., rating processes and outcomes). This study aims to start to address this research gap. As part of a larger study on rater…

  16. State of Research on Giftedness and Gifted Education: A Survey of Empirical Studies Published during 1998-2010 (April)

    ERIC Educational Resources Information Center

    Dai, David Yun; Swanson, Joan Ann; Cheng, Hongyu

    2011-01-01

    This study surveyed 1,234 empirical studies on giftedness, gifted education, and creativity during 1998-2010 (April), using PsycINFO database and targeted journals as main sources, with respect to main topics these studies focused on, methods they used for investigation, and the conceptual spaces they traversed. Four main research topics emerged…

  17. A Family-Centered Positive Behavior Support Approach to the Amelioration of Food Refusal Behavior: An Empirical Case Study

    ERIC Educational Resources Information Center

    Binnendyk, Lauren; Lucyshyn, Joseph M.

    2009-01-01

    The purpose of this study was to evaluate the effectiveness of a family-centered positive behavior support approach to the amelioration of food refusal behavior in a child with autism. The study was conducted with the child and his family in their home. It employed an empirical case study design with one meal routine: snack time. Following…

  18. Prostaglandins: a report on early clinical studies

    PubMed Central

    Hinman, J. W.

    1970-01-01

    The prostaglandins are a unique group of pharmacologically active lipids which are widely distributed in mammalian tissues and body fluids. The chemistry of this family of compounds has been established in elegant detail. Research quantities of these highly active natural compounds were obtained by enzymatic bioconversion of essential fatty acids and now studies devoted to the elucidation of their physiological roles and their clinical potential are progressing rapidly. Fields of greatest current interest in clinical medicine include renal-cardiovascular research, induction of labour and therapeutic abortion, control of the reproductive cycle (including fertility control), bronchodilation, enhancement of nasal patency and antisecretory activity. Results available to date are too preliminary for many conclusions to be drawn, but are sufficiently encouraging to assure continued and expanding efforts in several fields. PMID:4098885

  19. Empirically Supported Treatments in Psychotherapy: Towards an Evidence-Based or Evidence-Biased Psychology in Clinical Settings?

    PubMed Central

    Castelnuovo, Gianluca

    2010-01-01

    The field of research and practice in psychotherapy has been deeply influenced by two different approaches: the empirically supported treatments (ESTs) movement, linked with the evidence-based medicine (EBM) perspective and the “Common Factors” approach, typically connected with the “Dodo Bird Verdict”. About the first perspective, since 1998 a list of ESTs has been established in mental health field. Criterions for “well-established” and “probably efficacious” treatments have arisen. The development of these kinds of paradigms was motivated by the emergence of a “managerial” approach and related systems for remuneration also for mental health providers and for insurance companies. In this article ESTs will be presented underlining also some possible criticisms. Finally complementary approaches, that could add different evidence in the psychotherapy research in comparison with traditional EBM approach, are presented. PMID:21833197

  20. Moral Reasoning among HEC Members: An Empirical Evaluation of the Relationship of Theory and Practice in Clinical Ethics Consultation.

    PubMed

    Wasserman, Jason Adam; Stevenson, Shannon Lindsey; Claxton, Cassandra; Krug, Ernest F

    2015-01-01

    In light of the ongoing development and implementation of core competencies in bioethics, it is important to proceed with a clear sense of how bioethics knowledge is utilized in the functioning of hospital ethics committees (HECs). Without such an understanding, we risk building a costly edifice on a foundation that is ambiguous at best. This article examines the empirical relationship between traditional paradigms of bioethics theory and actual decision making by HEC members using survey data from HEC members. The assumption underlying the standardization of qualifications and corresponding call for increased education of HEC members is that they will base imminent case decisions on inculcated knowledge. Our data suggest, however, that HEC members first decide intuitively and then look for justification, thereby highlighting the need to re-examine the pedagogical processes of ethics education in the process of standardizing and improving competencies. PMID:26132057

  1. Clinical studies with tumour necrosis factor.

    PubMed

    Spriggs, D R; Sherman, M L; Frei, E; Kufe, D W

    1987-01-01

    The mechanism of tumour necrosis factor (TNF) cytotoxicity remains unknown. The in vivo antitumour effects of TNF may be related to direct cytotoxicity, immunomodulatory effects or endothelial effects on tumour vasculature. Phase I and early Phase II clinical trials of human recombinant TNF are under way in Japan, the USA, the UK and Germany. The maximum Phase II dose for TNF has not been established. The clinical toxicity of TNF is generally similar to that of other biological agents. Systemic toxicity, including fever, chills, anorexia and nausea, has been seen in most patients treated with TNF and has not been clearly related to dose. Other toxicities have included liver function abnormalities, hypotension, transient neurological changes and haematological abnormalities. Few clinical responses have been reported but organized Phase II testing remains to be completed. Combination trials with interferons have recently been initiated. Phase II efficacy studies of TNF as a single agent and in combination are needed for an assessment of the value of this agent in cancer therapy. PMID:3330011

  2. Neurobiology of early life stress: clinical studies.

    PubMed

    Heim, Christine; Nemeroff, Charles B

    2002-04-01

    A burgeoning number of clinical studies have evaluated the immediate and long-term neurobiological effects of early developmental stress, eg, child abuse and neglect or parental loss, in the past years. This review summarizes and discusses the available findings from neuroendocrine (hypothalamic-pituitary-adrenal axis, other neuroendocrine axes), neurochemical (catecholamines, serotonin, other neurotransmitters), psychophysiological (autonomic function, startle reactivity, brain electrical activity) and neuroimaging studies (brain structure, function) conducted in children or adults with a history of early life stress, with or without psychiatric disorders. Early developmental stress in humans appears to be associated with neurobiological alterations that are similar to many findings in animal models of early life stress, and likely represent the biological basis of an enhanced risk for psychopathology. Clinical studies are now beginning to explore potentially differential neurobiological effects of different types of early life stress and the existence of critical developmental periods, which may be sensitive to the neurobiological effects of specific stressors. In addition, the role of a multitude of moderating and mediating factors in the determination of individual vulnerability or resilience to the neurobiological effects of early life stress should be addressed. Findings from such studies may ultimately help to prevent the deleterious neurobiological and psychopathological consequences in the unacceptably high number of children exposed to early life stress in modern society. PMID:11953939

  3. Clinical studies in lysosomal storage diseases

    PubMed Central

    Boudes, Pol F

    2013-01-01

    Lysosomal storage disorders (LSDs) consist of over 40 diseases, some of which are amenable to treatment. In this review, we consider the regulatory context in which LSDs studies are performed, highlight design specificities and explore operational challenges. Orphan drug legislations, both in Europe and US, were effective to stimulate LSDs drug development. However, regulators flexibilities toward approval vary leading to global discrepancies in access to treatments. Study designs are constrained because few patients can be studied. This implies LSDs treatments need to demonstrate large levels of clinical efficacy. If not, an appropriate level of evidence is difficult to achieve. While biomarkers could address this issue, none have been truly accepted as primary outcome. Enrichment of study population can increase the chance of success, especially with clinical outcomes. Adaptive designs are operationally challenging. Innovative methods of analysis can be used, notably using a patient as his/her own control and responder analysis. The use of extension phases and patient registries as a source of historical comparison can facilitate data interpretation. Operationally, few patients are available per centers and multiple centers need to be initiated in multiple countries. This impacts time-lines and budget. In the future, regulators flexibility will be essential to provide patients access to innovative treatments. PMID:25003011

  4. Application of the empirical orthogonal function to study the rainfall pattern in Daerah Istimewa Yogyakarta province

    NASA Astrophysics Data System (ADS)

    Adi-Kusumo, Fajar; Gunardi, Utami, Herni; Nurjani, Emilya; Sopaheluwakan, Ardhasena; Aluicius, Irwan Endrayanto; Christiawan, Titus

    2016-02-01

    We consider the Empirical Orthogonal Function (EOF) to study the rainfall pattern in Daerah Istimewa Yogyakarta (DIY) Province, Indonesia. The EOF is one of the important methods to study the dominant pattern of the data using dimension reduction technique. EOF makes possible to reduce the huge dimension of observed data into a smaller one without losing its significant information in order to figures the whole data. The methods is also known as Principal Components Analysis (PCA) which is conducted to find the pattern of the data. DIY Province is one of the province in Indonesia which has special characteristics related to the rainfall pattern. This province has an active volcano, karst, highlands, and also some lower area including beach. This province is bounded by the Indonesian ocean which is one of the important factor to provide the rainfall. We use at least ten years rainfall monthly data of all stations in this area and study the rainfall characteristics based on the four regencies of the province. EOF analysis is conducted to analyze data in order to decide the station groups which have similar characters.

  5. Instructional Skills for On-the-Job Training and Experiential Learning: An Empirical Study of Japanese Firms

    ERIC Educational Resources Information Center

    Matsuo, Makoto

    2014-01-01

    Despite the effectiveness of on-the-job training (OJT), few systematic empirical studies have been conducted on how OJT trainers instruct trainees in firms. The primary goal of this study was to investigate the characteristics of the trainer's instructional skills for OJT using survey data collected from 715 employees covering 22 firms.…

  6. Does Look-up Frequency Help Reading Comprehension of EFL Learners? Two Empirical Studies of Electronic Dictionaries

    ERIC Educational Resources Information Center

    Koyama, Toshiko; Takeuchi, Osamu

    2007-01-01

    Two empirical studies were conducted in which the differences in Japanese EFL learners' look-up behavior between hand-held electronic dictionaries (EDs) and printed dictionaries (PDs) were investigated. We focus here on the relation between learners' look-up frequency and degree of reading comprehension of the text. In the first study, a total of…

  7. Racial Diversity, Student Religiosity, and School Choice: An Empirical Case Study of Multi-Racial Religious Education

    ERIC Educational Resources Information Center

    Reichard, Joshua D.

    2014-01-01

    This article comprises an empirical case study of student religiosity in the context of urban school choice. The purpose of this study was to compare student religiosity in a racially diverse religious private school to determine whether religious faith is a unifying factor across racial categories. Insofar as school choice has been called…

  8. How Physics Teachers Approach Innovation: An Empirical Study for Reconstructing the Appropriation Path in the Case of Special Relativity

    ERIC Educational Resources Information Center

    De Ambrosis, Anna; Levrini, Olivia

    2010-01-01

    This paper concerns an empirical study carried out with a group of high school physics teachers engaged in the Module on relativity of a Master course on the teaching of modern physics. The study is framed within the general research issue of how to promote innovation in school via teachers' education and how to foster fruitful interactions…

  9. Evaluation of Empirical Data and Modeling Studies to Support Soil Vapor Intrusion Screening Criteria for Petroleum Hydrocarbon Compounds

    EPA Science Inventory

    This study is an evaluation of empirical data and select modeling studies of the behavior of petroleum hydrocarbon (PHC) vapors in subsurface soils and how they can affect subsurface-to-indoor air vapor intrusion (VI), henceforth referred to as petroleum vapor intrusion or “PVI” ...

  10. An Automated System for Generating Situation-Specific Decision Support in Clinical Order Entry from Local Empirical Data

    ERIC Educational Resources Information Center

    Klann, Jeffrey G.

    2011-01-01

    Clinical Decision Support is one of the only aspects of health information technology that has demonstrated decreased costs and increased quality in healthcare delivery, yet it is extremely expensive and time-consuming to create, maintain, and localize. Consequently, a majority of health care systems do not utilize it, and even when it is…

  11. Plantago ovata: Clinical study of overuse.

    PubMed

    Agha, Rukh-e-Nasreen; Saeed, Aftab; Nazar, Halima

    2016-03-01

    The objective of the study was to undertake evidence-base study to evaluate clinical manifestation of the over-estimated use of herbal drug Plantago ovata and to compare it with placebo for the efficacy and adverse effects. The patients of both genders were included. Blood urea, creatinine, ALT, Serum B12, CP, ESR and liver function tests were performed. The data was statistically analyzed in both groups for differential symptomatology. In anorexia test verses control results showed that Plantago ovata husk and placebo showed the affected ratio as 81 percent and 50 percent, correspondingly. Whereas in clinical performance of heart burning, pain in epigastrium, low libido, body pain, dyspepsia, fever, burning sensation in palm and sole in test drug showed affected response as adverse effect 90%, 88% and as control drug, 36%, 29%, 22%, 25%, 38%, 30%, 33%, 57%, respectively. The results were highly marked in test drug i.e. in comparison with placebo. This is clearly evident from data analysis that effect observed in test arm is far more superior hence null hypothesis was rejected clearly. Similarly serological and biochemical reports study i.e. (ALT, Vit. B1 and Vit A) revealed that there is no hepatotoxic and neurotoxic effect found in both the drugs. PMID:27087080

  12. Doxofylline and Theophylline: A Comparative Clinical Study

    PubMed Central

    Akram, MD Faiz; Nasiruddin, Mohammad; Ahmad, Zuber; Ali Khan, Rahat

    2012-01-01

    Objectives COPD is one of the major public health problems worldwide. Theophylline has been used in the treatment of COPD for decades. Doxofylline a new theophylline congener has been claimed to have better safety profile. The study was undertaken to compare theophylline and doxophylline at doses recommended and commonly used in clinical practice. Methods The study was conducted in patients of COPD in TB chest department of a medical college hospital. It was randomized, prospective and open label. A total of 154 patients were divided in two group .Group I was administered 400 mg theophylline SR once daily and group II was administered doxofylline 400 mg twice a day orally. Spirometric variables symptom score, and adverse effects were recorded on day 0, 7 and 21 of therapy. Data were compared and analysed using SPSS version 16. Results Results of the study showed that there was no statistically significant difference with respect to spirometric variables and symptom score in the two groups and there was no significant difference in two groups with respect to side effects (p>0.05). Conclusions It is concluded that doxophylline has no advantage over theophylline in terms of either efficacy or safety on the doses commonly used in current clinical practice. PMID:23373027

  13. Clinical laboratory studies in Barth Syndrome.

    PubMed

    Vernon, Hilary J; Sandlers, Yana; McClellan, Rebecca; Kelley, Richard I

    2014-06-01

    Barth Syndrome is a rare X-linked disorder characterized principally by dilated cardiomyopathy, skeletal myopathy and neutropenia and caused by defects in tafazzin, an enzyme responsible for modifying the acyl chain moieties of cardiolipin. While several comprehensive clinical studies of Barth Syndrome have been published detailing cardiac and hematologic features, descriptions of its biochemical characteristics are limited. To gain a better understanding of the clinical biochemistry of this rare disease, we measured hematologic and biochemical values in a cohort of Barth Syndrome patients. We characterized multiple biochemical parameters, including plasma amino acids, plasma 3-methylglutaconic acid, cholesterol, cholesterol synthetic intermediates, and red blood cell membrane fatty acid profiles in 28 individuals with Barth Syndrome from ages 10 months to 30 years. We describe a unique biochemical profile for these patients, including decreased plasma arginine levels. We further studied the plasma amino acid profiles, cholesterol, cholesterol synthetic intermediates, and plasma 3-methylglutaconic acid levels in 8 female carriers and showed that they do not share any of the distinct, Barth Syndrome-specific biochemical laboratory abnormalities. Our studies augment and expand the biochemical profiles of individuals with Barth Syndrome, describe a unique biochemical profile for these patients, and provide insight into the possible underlying biochemical pathology in this disorder. PMID:24751896

  14. Empirical Study of the Multiaxial, Thermomechanical Behavior of NiTiHf Shape Memory Alloys

    NASA Technical Reports Server (NTRS)

    Shukla, Dhwanil; Noebe, Ronald D.; Stebner Aaron P.

    2013-01-01

    An empirical study was conducted to characterize the multiaxial, thermomechanical responses of new high temperature NiTiHf alloys. The experimentation included loading thin walled tube Ni(sub 50.3)Ti(sub 29.7)Hf(sub 20) alloy samples along both proportional and nonproportional axial-torsion paths at different temperatures while measuring surface strains using stereo digital image correlation. A Ni(sub 50.3)Ti(sub 33.7)Hf(sub 16) alloy was also studied in tension and compression to document the effect of slightly depleting the Hf content on the constitutive responses of NiTiHf alloys. Samples of both alloys were made from nearly texture free polycrystalline material processed by hot extrusion. Analysis of the data shows that very small changes in composition significantly alter NiTiHf alloy properties, as the austenite finish (Af) temperature of the 16-at Hf alloy was found to be approximately 60 C less than the 20-at Hf alloy (approximately 120 C vs. 180 C). In addition, the 16-at Hf alloy exhibited smaller compressive transformation strains (2 vs. 2.5 percent). Multi-axial characterization of the 20-at % Hf alloy showed that while the random polycrystal transformation strains in tension (4 percent) and compression (2.5 percent) are modest in comparison with binary NiTi (6 percent, 4 percent), the torsion performance is superior (7 vs. 4 shear strain width to the pseudoelastic plateau).

  15. Definitions of love in a sample of British women: an empirical study using Q methodology.

    PubMed

    Watts, Simon; Stenner, Paul

    2014-09-01

    Social psychological research has increasingly acknowledged that any pretensions to a singular theory of love should be replaced with a concern about its affirmation and what people actually say and do in love's name. Lee's (1977) love styles research and Sternberg's (1995) theory of love as a story are prime examples. Despite traditional definitions of love in western cultures being dominated by feminine images and tales of gender difference, however, the personal definitions and experiences of women have received comparatively little empirical attention, particularly in recent years and despite some well-documented changes in their cultural circumstances. This study remedies that situation through presentation of a Q methodological study in which a convenience sample of 59 British women were asked to Q sort 54 single-word descriptors of love to define love as they had experienced it. Factor analysis of the resulting Q sorts revealed six distinct definitions of love, interpreted as 'attraction, passion & romance', 'unconditional love', 'sex & fun', 'friendship & spirituality', 'a permanent commitment', and 'separate people, separate lives'. The six definitions are then discussed in terms of their allegiance to traditionally feminine and/or masculine values and as a means of highlighting the changing face of Britain's relational culture. PMID:24020933

  16. Situation Analysis of R & D Activities: An Empirical Study in Iranian Pharmaceutical Companies

    PubMed Central

    Rasekh, Hamid Reza; Mehralian, Gholamhossein; Vatankhah-Mohammadabadi, Abbas Ali

    2012-01-01

    As global competition intensifies, research and development (R & D) organizations need to enhance their strategic management in order to become goal-directed communities for innovation and allocate their resources consistent with their overall R & D strategy. The world pharmaceutical market has undergone fast, unprecedented, tremendous and complex changes in the last several years. The pharmaceutical industry is today still one of the most inventive, innovative and lucrative of the so-called “high-tech” industries. This industry serves a dual role in modern society. On one hand, it is a growing industry, and its output makes a direct contribution to gross domestic product (GDP). On the other side, drugs, this industry’s major output, are an input in the production of good health. The purpose of this study is to evaluate R & D activities of pharmaceutical companies, and also to highlight critical factors which have influential effect on results of these activities. To run this study a valid questionnaire based on literature review and experts’ opinion was designed and delivered to 11 pharmaceutical companies. Empirical data show there is not acceptable situations considering of the factors that should be taken in to account by managers including; management commitment, human resource management, information technology and financial management. Furthermore, we concluded some interesting results related to different aspects of R & D management. In conclusion, managers must be aware about their performance in R & D activities, accordingly they will able to take a comprehensive policy in both national and within the company. PMID:24250532

  17. Impact of Inappropriate Empiric Antimicrobial Therapy on Mortality of Septic Patients with Bacteremia: A Retrospective Study

    PubMed Central

    Lueangarun, Saoraya; Leelarasamee, Amorn

    2012-01-01

    Background. Inappropriate empiric antimicrobials could be a major cause of unfavorable mortality rates in co-morbid patients. This study aimed to assess the prevalence and impact of first-dose and 24-hour inappropriate antimicrobials on mortality rates of bacteremic septic patients. Methods. A retrospective cohort study was employed. Case record forms of patients diagnosed as sepsis, severe sepsis, or septic shock with positive hemoculture during 2009 were retrieved from the medical wards, Siriraj Hospital. Demographic data, antimicrobial use, types of bacteria isolated from blood and susceptibilities, patients' comorbidities, 28-day and overall mortality rates were collected and analyzed. Results. There were 229 cases, mean age (SD) of 63.5 (17.2) years and mean (SD) APACHE II score of 24.7 (6.8). The prevalence of first-dose and 24-hour inappropriate antimicrobials was 29.7% and 25.3%, respectively. The 28-day and overall mortality rates between first-dose inappropriate and appropriate antimicrobial were 67.6% versus 60.2% (P = 0.301) and 75.0% versus 68.3% (P = 0.345), consequently. Patients with septic shock and inappropriate first-dose antimicrobials significantly had higher 28-day mortality rate (61.6% versus 41.9%; P = 0.017). Conclusion. Higher mortality rates in bacteremic septic patients were substantially associated with inappropriate first-dose antimicrobials and 3-hour delayed antimicrobial administration after sepsis diagnosis. PMID:22919379

  18. Direct-to-Consumer Genetic Testing and Personal Genomics Services: A Review of Recent Empirical Studies

    PubMed Central

    Ostergren, Jenny

    2013-01-01

    Direct-to-consumer genetic testing (DTC-GT) has sparked much controversy and undergone dramatic changes in its brief history. Debates over appropriate health policies regarding DTC-GT would benefit from empirical research on its benefits, harms, and limitations. We review the recent literature (2011-present) and summarize findings across (1) content analyses of DTC-GT websites, (2) studies of consumer perspectives and experiences, and (3) surveys of relevant health care providers. Findings suggest that neither the health benefits envisioned by DTC-GT proponents (e.g., significant improvements in positive health behaviors) nor the worst fears expressed by its critics (e.g., catastrophic psychological distress and misunderstanding of test results, undue burden on the health care system) have materialized to date. However, research in this area is in its early stages and possesses numerous key limitations. We note needs for future studies to illuminate the impact of DTC-GT and thereby guide practice and policy regarding this rapidly evolving approach to personal genomics. PMID:24058877

  19. Situation analysis of R & d activities: an empirical study in Iranian pharmaceutical companies.

    PubMed

    Rasekh, Hamid Reza; Mehralian, Gholamhossein; Vatankhah-Mohammadabadi, Abbas Ali

    2012-01-01

    As global competition intensifies, research and development (R & D) organizations need to enhance their strategic management in order to become goal-directed communities for innovation and allocate their resources consistent with their overall R & D strategy. The world pharmaceutical market has undergone fast, unprecedented, tremendous and complex changes in the last several years. The pharmaceutical industry is today still one of the most inventive, innovative and lucrative of the so-called "high-tech" industries. This industry serves a dual role in modern society. On one hand, it is a growing industry, and its output makes a direct contribution to gross domestic product (GDP). On the other side, drugs, this industry's major output, are an input in the production of good health. The purpose of this study is to evaluate R & D activities of pharmaceutical companies, and also to highlight critical factors which have influential effect on results of these activities. To run this study a valid questionnaire based on literature review and experts' opinion was designed and delivered to 11 pharmaceutical companies. Empirical data show there is not acceptable situations considering of the factors that should be taken in to account by managers including; management commitment, human resource management, information technology and financial management. Furthermore, we concluded some interesting results related to different aspects of R & D management. In conclusion, managers must be aware about their performance in R & D activities, accordingly they will able to take a comprehensive policy in both national and within the company. PMID:24250532

  20. Hardness Analysis and Empirical Studies of the Relations among Robustness, Topology and Flow in Dynamic Networks

    PubMed Central

    Zhou, Xing; Peng, Wei; Xu, Zhen; Yang, Bo

    2015-01-01

    Network robustness is the ability of a network to maintain performance after disruption, thus it is an important index for network designers to refer to. Every actual network has its own topology structure, flow magnitude (scale) and flow distribution. How the robustness relates to these factors still remains unresolved. To analyze the relations, we first established a robustness problem model, studied the hardness of a special case of the model, and generated a lot of representative network instances. We conducted experiments on these instances, deleting 5% to 50% edges on each instance and found that the robustness of a network has an approximate linearity to its structural entropy and flow entropy, when the correlation coefficient between the structure and flow is fixed. We also found that robustness is unlikely to have a relation to the flow scale and edge scale in our model. The empirical studies thus can provide a way of quickly estimating the robustness of real-world networks by using the regression coefficients we obtained during the experiments. We conducted computation on a real-world dataset and got favorable results, which exhibited the effectiveness of the estimation. PMID:26695517

  1. Empirical and Analytic Studies Human/Automation Dynamics in Airspace Management for Free Flight

    NASA Technical Reports Server (NTRS)

    Corker, Kevin M.; Planich, G.; Bunzo, M.; Labacqz, J. Victor (Technical Monitor)

    1997-01-01

    NASA and the FAA have initiated programs of research and development to provide flight crew, airline operations and air traffic managers with automation aids to increase capacity in en route and terminal area to support the goals of free flight for safe, flexible, predictable, and efficient operations. To support the development of those aiding systems human performance in automated aiding has been examined in empirical and computationally analytic studies. This paper presents a set of those studies in full mission simulation and the development of a predictive computational model of human performance. We have found that the combination of methodologies provide a powerful design-aiding process. We will describe three research programs in support of Free Flight Operations from the perspective of human performance requirements. We have examined procedures and communications in the use of voice and data-link operation at the transition between unconstrained (enroute) and constrained (terminal) airspace operations. We have examined the timing and form of Center TRACON Automation System (CTAS) advisories in descent. We have investigated the shape and dimensions of an 'alert zone' for air-based separation in unconstrained operations. Finally, we have examined the interaction of a ground-based conflict detection/resolution aiding system, as it interacts with a cockpit-based conflict alerting mechanism. Additional information is contained in the original extended abstract.

  2. Significant factors of aviation insurance and risk management strategy: an empirical study of Taiwanese airline carriers.

    PubMed

    Lin, Yi Hsin; Chang, Yu Hern

    2008-04-01

    Aviation insurance premiums have become a heavy burden for the airline industry since September 11, 2001. Although the industry must constantly balance its operations between profitability and safety, the reality is that airlines are in the business of making money. Therefore, their ability to reduce cost and manage risk is a key factor for success. Unlike past research, which used subjective judgment methods, this study applied quantitative historical data (1999-2000) and gray relation analysis to identify the primary factors influencing ratemaking for aviation insurance premiums. An empirical study of six airlines in Taiwan was conducted to determine these factors and to analyze the management strategies used to deal with them. Results showed that the loss experience and performance of individual airlines were the key elements associated with aviation insurance premiums paid by each airline. By identifying and understanding the primary factors influencing ratemaking for aviation insurance, airlines will better understand their relative operational strengths and weaknesses, and further help top management identify areas for further improvement. Knowledge of these factors combined with effective risk management strategies, may result in lower premiums and operating costs for airline companies. PMID:18419661

  3. Indoor air quality study in Agency Building Two, Empire State Plaza, Albany, New York

    SciTech Connect

    Not Available

    1992-04-01

    The quality of the indoor environment and potential health conquences have become major concerns for occupants of office buildings. Increasing ventilation rates are often recommended as a potential solution for indoor air quality (IAQ) problems, whether real or perceived as real by occupants. To date, limited quantitative data have been collected to relate increased outdoor-air intake to commonly measured IAQ or comfort parameters. The purpose of this study, conducted by GEOMET Technologies, Inc. for the New York State Energy Research and Development Authority, was to quantitatively assess the effect of ventilation rate on indoor air quality and associated parameters in an occupied office building, and occupant perceptions of air quality and comfort in the building. The building studied, a 20-story office tower located at the Empire State Plaza in Albany, New York, has a total floor area of approximately 100,000 ft. The building is operated by the New York State Office of General Services (OGS). The air-distribution component of the heating, ventilating, and air-conditioning (HVAC) system for the building consists of two air-handling units that serve the perimeter of the building through induction supply-air units and two other units that serve the core area of the building through ceiling diffusers. The perimeter system has separate zones that serve the north and south sides of the building, and the core system is zoned to individually serve the upper and lower halves of the building.

  4. Clinical studies of neuroinflammatory mechanisms in schizophrenia.

    PubMed

    Watkins, Crystal C; Andrews, Sarah Ramsay

    2016-09-01

    Schizophrenia is a pervasive neurodevelopmental disorder that appears to result from genetic and environmental factors. Although the dopamine hypothesis is the driving theory behind the majority of translation research in schizophrenia, emerging evidence suggests that aberrant immune mechanisms in the peripheral and central nervous system influence the etiology of schizophrenia and the pathophysiology of psychotic symptoms that define the illness. The initial interest in inflammatory processes comes from epidemiological data and historical observations, dating back several decades. A growing body of research on developmental exposure to infection, stress-induced inflammatory response, glial cell signaling, structural and functional brain changes and therapeutic trials demonstrates the impact that inflammation has on the onset and progression of schizophrenia. Research in animal models of psychosis has helped to advance clinical and basic science investigations of the immune mechanisms disrupted in schizophrenia. However, they are limited by the inability to recapitulate the human experience of hallucinations, delusions and thought disorder that define psychosis. To date, translational studies of inflammatory mechanisms in human subjects have not been reviewed in great detail. Here, we critically review clinical studies that focus on inflammatory mechanisms in schizophrenia. Understanding the neuroinflammatory mechanisms involved in schizophrenia may be essential in identifying potential therapeutic targets to minimize the morbidity and mortality of schizophrenia by interrupting disease development. PMID:26235751

  5. A Conceptual and Empirical Review of the Meaning, Measurement, Development, and Teaching of Intervention Competence in Clinical Psychology

    PubMed Central

    Barber, Jacques P.

    2009-01-01

    Through the course of this paper we discuss several fundamental issues related to the intervention competence of psychologists. Following definitional clarification and proposals for more strictly distinguishing competence from adherence, we interpret Dreyfus and Dreyfus’s (1986) five stage theory of competence development (from novice to expert) within a strictly clinical framework. Existing methods of competence assessment are then evaluated, and we argue for the use of new and multiple assessment modalities. Next, we utilize the previous sections as a foundation to propose methods for training and evaluating competent psychologists. Lastly, we discuss several potential impediments to large scale competence assessment and education, such as the heterogeneity of therapeutic orientations and what could be termed a lack of transparency in clinical training. PMID:18952334

  6. Study Addiction – A New Area of Psychological Study: Conceptualization, Assessment, and Preliminary Empirical Findings

    PubMed Central

    Atroszko, Paweł A.; Andreassen, Cecilie Schou; Griffiths, Mark D.; Pallesen, Ståle

    2015-01-01

    Aims Recent research has suggested that for some individuals, educational studying may become compulsive and excessive and lead to ‘study addiction’. The present study conceptualized and assessed study addiction within the framework of workaholism, defining it as compulsive over-involvement in studying that interferes with functioning in other domains and that is detrimental for individuals and/or their environment. Methods The Bergen Study Addiction Scale (BStAS) was tested – reflecting seven core addiction symptoms (salience, mood modification, tolerance, withdrawal, conflict, relapse, and problems) – related to studying. The scale was administered via a cross-sectional survey distributed to Norwegian (n = 218) and Polish (n = 993) students with additional questions concerning demographic variables, study-related variables, health, and personality. Results A one-factor solution had acceptable fit with the data in both samples and the scale demonstrated good reliability. Scores on BStAS converged with scores on learning engagement. Study addiction (BStAS) was significantly related to specific aspects of studying (longer learning time, lower academic performance), personality traits (higher neuroticism and conscientiousness, lower extroversion), and negative health-related factors (impaired general health, decreased quality of life and sleep quality, higher perceived stress). Conclusions It is concluded that BStAS has good psychometric properties, making it a promising tool in the assessment of study addiction. Study addiction is related in predictable ways to personality and health variables, as predicted from contemporary workaholism theory and research. PMID:26014668

  7. Case studies in clinical practice development.

    PubMed

    Chopra, Romi; Lipman, John; Murphy, Timothy P

    2005-03-01

    By asking identical questions of several successful practitioners of clinical interventional radiology, a snapshot of the current and future status of interventional radiology as a clinical discipline is presented. PMID:21326672

  8. Institutional ethics review of clinical study agreements.

    PubMed

    DuVal, G

    2004-02-01

    Clinical Study Agreements (CSAs) can have profound effects both on the protection of human subjects and on the independence of investigators to conduct research with scientific integrity. Sponsors, institutions, and even investigators may fail to give adequate attention to these issues in the negotiation of CSAs. Despite the key role of CSAs in structuring ethically important aspects of research, they remain largely unregulated and unreviewed for adherence to ethical norms. Academic institutions routinely enter into research contracts that fail to meet adequate ethical standards. This is a failing that can have serious consequences. Accordingly, it is necessary that some independent body have the authority both to review research contracts for compliance with norms of subject protection and ethical integrity, and to reject studies that fail to meet ethical standards. Such review should take place prior to the start of research, not later. Because of its expertise and authority, the institutional ethics review board (IRB or REB) is the appropriate body to undertake such review. Much recent commentary has focused on contractual restrictions on the investigator's freedom to publish research findings. The Olivieri experience, and that of other investigators, has brought freedom of publication issues into sharp focus. Clinical study agreements also raise a number of other ethical issues relating to human subjects and research integrity, however, including disclosures relating to patient safety, data analysis and reporting, budget, confidentiality, and premature termination of the study. This paper describes the ethical issues at stake in structuring such agreements and suggests ethical standards to guide institutional ethics review. PMID:14872068

  9. Empirical Study of User Preferences Based on Rating Data of Movies

    PubMed Central

    Zhao, YingSi; Shen, Bo

    2016-01-01

    User preference plays a prominent role in many fields, including electronic commerce, social opinion, and Internet search engines. Particularly in recommender systems, it directly influences the accuracy of the recommendation. Though many methods have been presented, most of these have only focused on how to improve the recommendation results. In this paper, we introduce an empirical study of user preferences based on a set of rating data about movies. We develop a simple statistical method to investigate the characteristics of user preferences. We find that the movies have potential characteristics of closure, which results in the formation of numerous cliques with a power-law size distribution. We also find that a user related to a small clique always has similar opinions on the movies in this clique. Then, we suggest a user preference model, which can eliminate the predictions that are considered to be impracticable. Numerical results show that the model can reflect user preference with remarkable accuracy when data elimination is allowed, and random factors in the rating data make prediction error inevitable. In further research, we will investigate many other rating data sets to examine the universality of our findings. PMID:26735847

  10. Time Domain Strain/Stress Reconstruction Based on Empirical Mode Decomposition: Numerical Study and Experimental Validation.

    PubMed

    He, Jingjing; Zhou, Yibin; Guan, Xuefei; Zhang, Wei; Zhang, Weifang; Liu, Yongming

    2016-01-01

    Structural health monitoring has been studied by a number of researchers as well as various industries to keep up with the increasing demand for preventive maintenance routines. This work presents a novel method for reconstruct prompt, informed strain/stress responses at the hot spots of the structures based on strain measurements at remote locations. The structural responses measured from usage monitoring system at available locations are decomposed into modal responses using empirical mode decomposition. Transformation equations based on finite element modeling are derived to extrapolate the modal responses from the measured locations to critical locations where direct sensor measurements are not available. Then, two numerical examples (a two-span beam and a 19956-degree of freedom simplified airfoil) are used to demonstrate the overall reconstruction method. Finally, the present work investigates the effectiveness and accuracy of the method through a set of experiments conducted on an aluminium alloy cantilever beam commonly used in air vehicle and spacecraft. The experiments collect the vibration strain signals of the beam via optical fiber sensors. Reconstruction results are compared with theoretical solutions and a detailed error analysis is also provided. PMID:27537889

  11. Empirical study on a directed and weighted bus transport network in China

    NASA Astrophysics Data System (ADS)

    Feng, Shumin; Hu, Baoyu; Nie, Cen; Shen, Xianghao

    2016-01-01

    Bus transport networks are directed complex networks that consist of routes, stations, and passenger flow. In this study, the concept of duplication factor is introduced to analyze the differences between uplinks and downlinks for the bus transport network of Harbin (BTN-H). Further, a new representation model for BTNs is proposed, named as directed-space P. Two empirical characteristics of BTN-H are reported in this paper. First, the cumulative distributions of weighted degree, degree, number of routes that connect to each station, and node weight (peak-hour trips at a station) uniformly follow the exponential law. Meanwhile, the node weight shows positive correlations with the corresponding weighted degree, degree, and number of routes that connect to a station. Second, a new richness parameter of a node is explored by its node weight and the connectivity, weighted connectivity, average shortest path length and efficiency between rich nodes can be fitted by composite exponential functions to demonstrate the rich-club phenomenon.

  12. Molecular docking study and development of an empirical binding free energy model for phosphodiesterase 4 inhibitors.

    PubMed

    Oliveira, Fernanda G; Sant'Anna, Carlos M R; Caffarena, Ernesto R; Dardenne, Laurent E; Barreiro, Eliezer J

    2006-09-01

    In the present work, several computational methodologies were combined to develop a model for the prediction of PDE4B inhibitors' activity. The adequacy of applying the ligand docking approach, keeping the enzyme rigid, to the study of a series of PDE4 inhibitors was confirmed by a previous molecular dynamics analysis of the complete enzyme. An exhaustive docking procedure was performed to identify the most probable binding modes of the ligands to the enzyme, including the active site metal ions and the surrounding structural water molecules. The enzyme-inhibitor interaction enthalpies, refined by using the semiempirical molecular orbital approach, were combined with calculated solvation free energies and entropy considerations in an empirical free energy model that enabled the calculation of binding free energies that correlated very well with experimentally derived binding free energies. Our results indicate that both the inclusion of the structural water molecules close to the ions in the binding site and the use of a free energy model with a quadratic dependency on the ligand free energy of solvation are important aspects to be considered for molecular docking investigations involving the PDE4 enzyme family. PMID:16843671

  13. Reviewing the effort-reward imbalance model: drawing up the balance of 45 empirical studies.

    PubMed

    van Vegchel, Natasja; de Jonge, Jan; Bosma, Hans; Schaufeli, Wilmar

    2005-03-01

    The present paper provides a review of 45 studies on the Effort-Reward Imbalance (ERI) Model published from 1986 to 2003 (inclusive). In 1986, the ERI Model was introduced by Siegrist et al. (Biological and Psychological Factors in Cardiovascular Disease, Springer, Berlin, 1986, pp. 104-126; Social Science & Medicine 22 (1986) 247). The central tenet of the ERI Model is that an imbalance between (high) efforts and (low) rewards leads to (sustained) strain reactions. Besides efforts and rewards, overcommitment (i.e., a personality characteristic) is a crucial aspect of the model. Essentially, the ERI Model contains three main assumptions, which could be labeled as (1) the extrinsic ERI hypothesis: high efforts in combination with low rewards increase the risk of poor health, (2) the intrinsic overcommitment hypothesis: a high level of overcommitment may increase the risk of poor health, and (3) the interaction hypothesis: employees reporting an extrinsic ERI and a high level of overcommitment have an even higher risk of poor health. The review showed that the extrinsic ERI hypothesis has gained considerable empirical support. Results for overcommitment remain inconsistent and the moderating effect of overcommitment on the relation between ERI and employee health has been scarcely examined. Based on these review results suggestions for future research are proposed. PMID:15589679

  14. Empirical Study of User Preferences Based on Rating Data of Movies.

    PubMed

    Zhao, YingSi; Shen, Bo

    2016-01-01

    User preference plays a prominent role in many fields, including electronic commerce, social opinion, and Internet search engines. Particularly in recommender systems, it directly influences the accuracy of the recommendation. Though many methods have been presented, most of these have only focused on how to improve the recommendation results. In this paper, we introduce an empirical study of user preferences based on a set of rating data about movies. We develop a simple statistical method to investigate the characteristics of user preferences. We find that the movies have potential characteristics of closure, which results in the formation of numerous cliques with a power-law size distribution. We also find that a user related to a small clique always has similar opinions on the movies in this clique. Then, we suggest a user preference model, which can eliminate the predictions that are considered to be impracticable. Numerical results show that the model can reflect user preference with remarkable accuracy when data elimination is allowed, and random factors in the rating data make prediction error inevitable. In further research, we will investigate many other rating data sets to examine the universality of our findings. PMID:26735847

  15. Digital ethnography and the social dimension of introspection: an empirical study in two Colombian schools.

    PubMed

    Rieken, Johannes; Garcia-Sanchez, Efraín; Trujillo, Mónica Pérez; Bear, Daniel

    2015-06-01

    We developed a teaching-led research project to empirically ground methodological reflection about digital ethnography. Drawing on Cordelois' collective ethnographic observation approach, fifteen emerging professionals (from a private general education university and a Police Academy in Bogota) collaborated in a method seminar on digital ethnography. They worked in cross-institutional research teams, each carrying SenseCams for 3 days. Students had a dual role as both participants and observers during self-confrontation interviews. The research design enabled emerging professionals to introspect about what it is to be a member of their institution. The SenseCam provided an additional opportunity for observation as it elicited different reactions in the two institutions. The fact that SenseCams produce sequential accounts of activity as well as its situated nature made apparent the autonomy to study and solve daily issues (e.g. transport, security, commitments) by students from the university, while students in the police academy are more focused on responding to unforeseen activities (e.g. police services, unexpected requests). Finally, our research highlights the relevance of the social dimension of introspection for digital ethnography. How digital data that captures an individual perspective is negotiated in a group becomes a key methodological question. PMID:25757936

  16. Aviation occupant survival factors: an empirical study of the SQ006 accident.

    PubMed

    Chang, Yu-Hern; Yang, Hui-Hua

    2010-03-01

    We present an empirical study of Singapore Airline (SIA) flight SQ006 to illustrate the critical factors that influence airplane occupant survivability. The Fuzzy Delphi Method was used to identify and rank the survival factors that may reduce injury and fatality in potentially survivable accidents. This is the first attempt by a group from both the public and private sectors in Taiwan to focus on cabin-safety issues related to survival factors. We designed a comprehensive survey based on our discussions with aviation safety experts. We next designed an array of important cabin-safety dimensions and then investigated and selected the critical survival factors for each dimension. Our findings reveal important cabin safety and survivability information that should provide a valuable reference for developing and evaluating aviation safety programs. We also believe that the results will be practical for designing cabin-safety education material for air travelers. Finally, the major contribution of this research is that it has identified 47 critical factors that influence accident survivability; therefore, it may encourage improvements that will promote more successful cabin-safety management. PMID:20159096

  17. Comparative Study of Defect Properties in GaN: Ab initio and Empirical Potential Calculations

    SciTech Connect

    Gao, Fei; Bylaska, Eric J.; El-Azab, Anter; Weber, William J.; LM Wang, R Fromknecht, LL Snead, DF Downey and H Takahashi

    2004-04-05

    Density functional theory (DFT) is used to study the formation, properties and atomic configurations of monovacancies, antisite defects and possible interstitials in GaN. The relaxation around a vacancy is generally small, but the relaxation around antisite defects is large, particularly for a Ga antisite defect, which is not stable and converts to an N-N<0001> split interstitial. All N interstitials, starting from any possible sites, eventually transfer into the N-N split interstitials, forming N molecules. In the case of Ga interstitials, the most favorable configuration is the Ga octahedral interstitial. However, it is found that the Ga-Ga<> split interstitial can bridge the gap between non-bonded Ga atoms along the <11-2> direction, which leads to the formation of Ga atomic wires in GaN, with bond distance close to those noted in bulk Ga. In addition, two representative potentials, namely Stillinger-Weber and Tersoff-Brenner potentials, have been employed to deter mine the formation of defects using molecular dynamics (MD) method in GaN. The MD results are discussed and compared to DFT calculations. The present DFT and MD results provide guidelines for evaluating the quality and fit of empirical potentials for large-scale simulations of ion-solid interaction and thermal annealing of defects in GaN.

  18. An empirical study on information spillover effects between the Chinese copper futures market and spot market

    NASA Astrophysics Data System (ADS)

    Liu, Xiangli; Cheng, Siwei; Wang, Shouyang; Hong, Yongmiao; Li, Yi

    2008-02-01

    This study employs a parametric approach based on TGARCH and GARCH models to estimate the VaR of the copper futures market and spot market in China. Considering the short selling mechanism in the futures market, the paper introduces two new notions: upside VaR and extreme upside risk spillover. And downside VaR and upside VaR are examined by using the above approach. Also, we use Kupiec’s [P.H. Kupiec, Techniques for verifying the accuracy of risk measurement models, Journal of Derivatives 3 (1995) 73-84] backtest to test the power of our approaches. In addition, we investigate information spillover effects between the futures market and the spot market by employing a linear Granger causality test, and Granger causality tests in mean, volatility and risk respectively. Moreover, we also investigate the relationship between the futures market and the spot market by using a test based on a kernel function. Empirical results indicate that there exist significant two-way spillovers between the futures market and the spot market, and the spillovers from the futures market to the spot market are much more striking.

  19. Empirical Study on Designing of Gaze Tracking Camera Based on the Information of User's Head Movement.

    PubMed

    Pan, Weiyuan; Jung, Dongwook; Yoon, Hyo Sik; Lee, Dong Eun; Naqvi, Rizwan Ali; Lee, Kwan Woo; Park, Kang Ryoung

    2016-01-01

    Gaze tracking is the technology that identifies a region in space that a user is looking at. Most previous non-wearable gaze tracking systems use a near-infrared (NIR) light camera with an NIR illuminator. Based on the kind of camera lens used, the viewing angle and depth-of-field (DOF) of a gaze tracking camera can be different, which affects the performance of the gaze tracking system. Nevertheless, to our best knowledge, most previous researches implemented gaze tracking cameras without ground truth information for determining the optimal viewing angle and DOF of the camera lens. Eye-tracker manufacturers might also use ground truth information, but they do not provide this in public. Therefore, researchers and developers of gaze tracking systems cannot refer to such information for implementing gaze tracking system. We address this problem providing an empirical study in which we design an optimal gaze tracking camera based on experimental measurements of the amount and velocity of user's head movements. Based on our results and analyses, researchers and developers might be able to more easily implement an optimal gaze tracking system. Experimental results show that our gaze tracking system shows high performance in terms of accuracy, user convenience and interest. PMID:27589768

  20. An empirical study on the driving mechanism of proactive corporate environmental management in China.

    PubMed

    Liu, Xianbing; Liu, Beibei; Shishime, Tomohiro; Yu, Qinqin; Bi, Jun; Fujitsuka, Tetsuro

    2010-08-01

    Environmentalism in China is under transformation from the traditional command and control model to emphasize the advantages of economic tools and encourage the participation of the public. Firms are much more aware of the importance of environmental issues, and some of them have practiced environmental activities beyond compliance. In order to help understand the driving mechanism of proactive corporate environmental behaviors from the firm's perspective, this paper identifies the drivers affecting the proactive environmental management level (EML(p)) based on the institutional theory, and gives an empirical study on the firms based in Changshu city of Jiangsu Province, China. The usable data, collected from the 117 valid respondents in a questionnaire survey, indicates that EML(p) is still moderately low currently. Less than 10% of the samples are practicing all the six categorized types of voluntary environmental activities. The econometric exercise confirms a significantly positive effect of the externally mimetic pressure on EML(p), which may attribute to a higher sensitivity of Chinese companies to the market factors. However, the roles of the general public and industrial associations are not significant, showing the marginal power of selected normative pressures. Regarding internal factors, firms, which view environmental issues as opportunities and often arrange internal environmental training, are more likely to adopt proactive environmental activities. More concerns from the general public like neighborhood communities and mass media shall be addressed to enhance the normative power to improve EML(p) in China from the future perspective. PMID:20399552

  1. Gaps in studies of global health education: an empirical literature review

    PubMed Central

    Liu, Yan; Zhang, Ying; Liu, Zhaolan; Wang, JianLi

    2015-01-01

    Background Global health has stimulated a lot of students and has attracted the interest of many faculties, thereby initiating the establishment of many academic programs on global health research and education. global health education reflects the increasing attention toward social accountability in medical education. Objective This study aims to identify gaps in the studies on global health education. Design A critical literature review of empirical studies was conducted using Boolean search techniques. Results A total of 238 articles, including 16 reviews, were identified. There had been a boom in the numbers of studies on global health education since 2010. Four gaps were summarized. First, 94.6% of all studies on global health education were conducted in North American and European countries, of which 65.6% were carried out in the United States, followed by Canada (14.3%) and the United Kingdom (9.2%). Only seven studies (2.9%) were conducted in Asian countries, five (2.1%) in Oceania, and two (0.8%) in South American/Caribbean countries. A total of 154 studies (64.4%) were qualitative studies and 64 studies (26.8%) were quantitative studies. Second, elective courses and training or programs were the most frequently used approach for global health education. Third, there was a gap in the standardization of global health education. Finally, it was mainly targeted at medical students, residents, and doctors. It had not granted the demands for global health education of all students majoring in medicine-related studies. Conclusions Global health education would be a potentially influential tool for achieving health equity, reducing health disparities, and also for future professional careers. It is the time to build and expand education in global health, especially among developing countries. Global health education should be integrated into primary medical education. Interdisciplinary approaches and interprofessional collaboration were recommended. Collaboration

  2. [Cardiac myxoma in the elderly. Clinical study].

    PubMed

    Pentimone, F; Del Corso, L; Siuti, E; Verunelli, F; Bortolotti, U; Salvatore, L

    1997-01-01

    Cardiac mixoma in the elderly. A clinical study. The clinical features of 13 cardiac myxomas surgically resected are presented. The mean age at presentation was 68 years. Ten were in the left atrium, 5 near the fossa ovalis, 3 at the base of the atrial septum, 1 at the inferior wall and 1 on the anterior leaflet of mitral valve, 3 were in the right atrium, 1 of these was accompanied with a myxoma at the apex of left ventricle. The ECG and the chest X-ray were normal in 9 and in 8 patients, respectively. In 3 patients, the diagnosis was occasionally made by routine 2-dimensional echocardiography. 5 patients presented with fever of unknown origin, arthralgias, weakness, weight loss. None had intracardiac or extracardiac recurrence in the 73 months follow-up. The presentation with constitutional symptoms only like fever of UO, may mimic collagen and neoplastic diseases, vasculitis, lymphomas: the 2-dimensional echocardiography is mandatory to esclude a cardiac myxoma in the elderly. PMID:9213810

  3. Controlled outcome studies of child clinical hypnosis.

    PubMed

    Adinolfi, Barbara; Gava, Nicoletta

    2013-08-01

    Background Hypnosis is defined as "as an interaction in which the hypnotist uses suggested scenarios ("suggestions") to encourage a person's focus of attention to shift towards inner experiences". Aim of the work The focus of this review is to summarize the findings of controlled outcome studies investigating the potential of clinical hypnosis in pediatric populations. We will examine the following themes: anesthesia, acute and chronic pain, chemotherapy-related distress, along with other specific medical issues. Results Hypnosis is an effective method to reduce pain and anxiety before, during and after the administration of anesthetics, during local dental treatments, invasive medical procedures and in burn children. Hypnosis can be successfully used to manage recurrent headaches, abdominal pain, irritable bowel syndrome and chemotherapy-related distress. Hypnosis has an important role in managing symptoms and improving the quality of life of children suffering from asthma and cystic fibrosis and in facilitating the treatment of insomnia in school-age children. Finally, hypnosis can be effectively used for the treatment of some habitual disorders such as nocturnal enuresis and dermatologic conditions, including atopic dermatitis and chronic eczema Conclusions Clinical hypnosis seems to be a useful, cheap and side-effects free tool to manage fear, pain and several kinds of stressful experiences in pediatric populations. Children who receive self-hypnosis trainings achieve significantly greater improvements in their physical health, quality of life, and self-esteem. PMID:24165457

  4. Clinical studies of intestinal folate conjugases.

    PubMed

    Halsted, C H; Beer, W H; Chandler, C J; Ross, K; Wolfe, B M; Bailey, L; Cerda, J J

    1986-03-01

    Clinical differences between the two human intestinal mucosal folate conjugases were assessed by measurement of their activities in normal individuals and in patients with chronic diarrhea of differing causes. Intracellular folate conjugase (ICFC) was 15-fold more active than brush border folate conjugase (BBFC) in jejunal mucosa from seven obese patients undergoing elective gastric bypass surgery. The activity of ICFC was similar among normal volunteers and patients with diarrhea of unknown origin (DUO), gluten-sensitive enteropathy (GSE), inflammatory bowel disease (IBD), and the short bowel syndrome (IBD-SBS). By contrast, BBFC, sucrase, and lactase were decreased significantly in GSE, and BBFC was increased in IBD-SBS. The activity of BBFC correlated with lactase and with sucrase in the normal subjects and in patients with DUO, whereas no correlations were found with the activity of ICFC in any group. Our clinical studies confirm that ICFC and BBFC are different enzymes. ICFC is not affected by intestinal disease, whereas the activity of jejunal BBFC, like that of other brush border enzymes, is decreased by mucosal injury and is also capable of adapting to distal small intestinal disease or surgical resection. PMID:3081671

  5. Impact of Intellectual Capital on Organisational Performance: An Empirical Study of Companies in the Hang Seng Index (Part 1)

    ERIC Educational Resources Information Center

    Chan, Kin Hang

    2009-01-01

    Purpose: The purpose of this paper, which is written in two parts, is to investigate empirically if intellectual capital (IC) has an impact on the financial aspects of organisational performance as well as attempting to identify the IC components that may be the drivers for the leading financial indicators of listed companies. The study sought…

  6. Impact of Intellectual Capital on Organisational Performance: An Empirical Study of Companies in the Hang Seng Index (Part 2)

    ERIC Educational Resources Information Center

    Chan, Kin Hang

    2009-01-01

    Purpose: The purpose of this paper, which is written in two parts, is to investigate empirically if intellectual capital (IC) has an impact on the financial aspects of organisational performance as well as attempting to identify the IC components that may be the drivers for the leading financial indicators of listed companies. The study sought…

  7. Behavioral Criteria of Mentoring Effectiveness: An Empirical Study of Formal Mentoring Relationships within a Major UK Public Sector Organization

    ERIC Educational Resources Information Center

    Hamlin, Robert G.; Sage, Lesley

    2008-01-01

    This paper describes an empirical study of mentor and mentee behaviors deemed critical for developing healthy mentoring relationships and effective mentoring during the "start up" and "on going" stages of a formal mentoring scheme within a major UK public sector organization. Several identified behavioral categories (criteria) of mentoring…

  8. Empirical Testing of a Theoretical Extension of the Technology Acceptance Model: An Exploratory Study of Educational Wikis

    ERIC Educational Resources Information Center

    Liu, Xun

    2010-01-01

    This study extended the technology acceptance model and empirically tested the new model with wikis, a new type of educational technology. Based on social cognitive theory and the theory of planned behavior, three new variables, wiki self-efficacy, online posting anxiety, and perceived behavioral control, were added to the original technology…

  9. The Impact of Student Composition on Schools' Value-Added Performance: A Comparison of Seven Empirical Studies

    ERIC Educational Resources Information Center

    Timmermans, Anneke C.; Thomas, Sally M.

    2015-01-01

    In many countries, policy makers struggle with the development of value-added indicators of school performance for educational accountability purposes and in particular with the choice whether school context measured in the form of student composition variables should be included. This study investigates differences between 7 empirical studies…

  10. An Empirical Study on Washback Effects of the Internet-Based College English Test Band 4 in China

    ERIC Educational Resources Information Center

    Wang, Chao; Yan, Jiaolan; Liu, Bao

    2014-01-01

    Based on Bailey's washback model, in respect of participants, process and products, the present empirical study was conducted to find the actual washback effects of the internet-based College English Test Band 4 (IB CET-4). The methods adopted are questionnaires, class observation, interview and the analysis of both the CET-4 teaching and testing…

  11. Impact of Globalization on Higher Education: An Empirical Study of Education Policy & Planning of Design Education in Hong Kong

    ERIC Educational Resources Information Center

    Lam, Yan Yan

    2010-01-01

    This paper focuses on the impact of globalization in the domain of higher education, particularly, design education. It reviews how globalization may affect educational policy and planning in Hong Kong by drawing on an empirical study involving senior management, a course leader and a design trainer/facilitator. This paper not only illustrates the…

  12. Macro-evolutionary studies of cultural diversity: a review of empirical studies of cultural transmission and cultural adaptation

    PubMed Central

    Mace, Ruth; Jordan, Fiona M.

    2011-01-01

    A growing body of theoretical and empirical research has examined cultural transmission and adaptive cultural behaviour at the individual, within-group level. However, relatively few studies have tried to examine proximate transmission or test ultimate adaptive hypotheses about behavioural or cultural diversity at a between-societies macro-level. In both the history of anthropology and in present-day work, a common approach to examining adaptive behaviour at the macro-level has been through correlating various cultural traits with features of ecology. We discuss some difficulties with simple ecological associations, and then review cultural phylogenetic studies that have attempted to go beyond correlations to understand the underlying cultural evolutionary processes. We conclude with an example of a phylogenetically controlled approach to understanding proximate transmission pathways in Austronesian cultural diversity. PMID:21199844

  13. Age and Sex Effects in Anchoring Vignette Studies: Methodological and Empirical Contributions*

    PubMed Central

    Grol-Prokopczyk, Hanna

    2014-01-01

    Anchoring vignettes are an increasingly popular tool for identifying and correcting for group differences in use of subjective ordered response categories. However, existing techniques to maximize response consistency (use of the same standards for self-ratings as for vignette-ratings), which center on matching vignette characters’ demographic characteristics to respondents’ own characteristics, appear at times to be ineffective or to pose interpretive difficulties. Specifically, respondents often appear to neglect instructions to treat vignette characters as age peers. Furthermore, when vignette characters’ sex is matched to respondents’ sex, interpretation of sex differences in rating style is rendered problematic. This study applies two experimental manipulations to a national American sample (n=1,765) to clarify best practices for enhancing response consistency. First, an analysis of two methods of highlighting vignette characters’ age suggests that both yield better response consistency than previous, less prominent means. Second, a comparison of ratings of same- and opposite-sex vignette characters suggests that, with avoidable exceptions, the sex of the respondent rather than of the vignette character drives observed sex differences in rating style. Implications for interpretation and design of anchoring vignette studies are discussed. In addition, this study clarifies the importance of two additional measurement assumptions, cross-respondent vignette equivalence and cross-character vignette equivalence. It also presents empirical findings of significant sex, educational, and racial/ethnic differences in styles of rating health, and racial/ethnic differences in styles of rating political efficacy. These findings underscore the incomparability of unadjusted subjective self-ratings across demographic groups, and thus support the potential utility of the anchoring vignette method. PMID:25621079

  14. Risk and Protective Factors of Internet Addiction: A Meta-Analysis of Empirical Studies in Korea

    PubMed Central

    Koo, Hoon Jung

    2014-01-01

    Purpose A meta-analysis of empirical studies performed in Korea was conducted to systematically investigate the associations between the indices of Internet addiction (IA) and psychosocial variables. Materials and Methods Systematic literature searches were carried out using the Korean Studies Information Service System, Research Information Sharing Service, Science Direct, Google Scholar, and references in review articles. The key words were Internet addiction, (Internet) game addiction, and pathological, problematic, and excessive Internet use. Only original research papers using Korean samples published from 1999 to 2012 and officially reviewed by peers were included for analysis. Ninety-five studies meeting the inclusion criteria were identified. Results The magnitude of the overall effect size of the intrapersonal variables associated with internet addiction was significantly higher than that of interpersonal variables. Specifically, IA demonstrated a medium to strong association with "escape from self" and "self-identity" as self-related variables. "Attention problem", "self-control", and "emotional regulation" as control and regulation-relation variables; "addiction and absorption traits" as temperament variables; "anger" and "aggression" as emotion and mood and variables; "negative stress coping" as coping variables were also associated with comparably larger effect sizes. Contrary to our expectation, the magnitude of the correlations between relational ability and quality, parental relationships and family functionality, and IA were found to be small. The strength of the association between IA and the risk and protective factors was found to be higher in younger age groups. Conclusion The findings highlight a need for closer examination of psychosocial factors, especially intrapersonal variables when assessing high-risk individuals and designing intervention strategies for both general IA and Internet game addiction. PMID:25323910

  15. A Systematic Review of CPAP Adherence Across Age Groups: Clinical and Empiric Insights for Developing CPAP Adherence Interventions

    PubMed Central

    Sawyer, A.M.; Gooneratne, N.; Marcus, C.L.; Ofer, D.; Richards, K.C.; Weaver, T.E.

    2011-01-01

    Continuous positive airway pressure (CPAP) is a highly efficacious treatment for obstructive sleep apnea (OSA) but adherence to the treatment limits its overall effectiveness across all age groups of patients. Factors that influence adherence to CPAP include disease and patient characteristics, treatment titration procedures, technological device factors and side effects, and psychological and social factors. These influential factors have guided the development of interventions to promote CPAP adherence. Various intervention strategies have been described and include educational, technological, psychosocial, pharmacological, and multi-dimensional approaches. Though evidence to date has led to innovative strategies that address adherence in CPAP-treated children, adults, and older adults, significant opportunities exist to develop and test interventions that are clinically applicable, specific to subgroups of patients likely to demonstrate poor adherence, and address the multifactorial nature of CPAP adherence. The translation of CPAP adherence promotion interventions to clinical practice is imperative to improve health and functional outcomes in all persons with CPAP-treated OSA. PMID:21652236

  16. Fulminant liver failure: clinical and experimental study.

    PubMed

    Slapak, M

    1975-11-01

    Clinical experience of some newer methods of hepatic support is described. The results are unpredictable and far from satisfactory. The need for an animal model in which potential therapeutic methods can be studied is emphasized. Such a model based on carefully imposed ischaemic insult to the liver in the absence of portacaval shunting is described. It is suggested that bacterial presence in the bowel together with a depression of the liver reticuloendothelial function plays an important part in the early and rapid mortality of acute liver failure. Temporary auxiliary liver transplantation using an allograft or a closely related primate heterograft seem to be the 2 best available methods of hepatic support for potentially reversible acute liver failure. PMID:812415

  17. Clinical studies of styrene workers: initial findings.

    PubMed Central

    Lorimer, W V; Lilis, R; Nicholson, W J; Anderson, H; Fischbein, A; Daum, S; Rom, W; Rice, C; Selikoff, I J

    1976-01-01

    Styrene monomer is a high volume chemical used chiefly in production of polystyrene. A clinical survey of 493 production workers was undertaken at the oldest and largest monomer production, polymerization, and extrusion facility in the U.S. Relative exposure durations and levels were obtained from occupational histories. Significant differences between the high and low exposure groups were found with regard to history of acute prenarcotic symptoms, acute lower respiratory symptoms, prevalence of FEV 1/FV less than 75 per cent, and elevated GCTP. Other liver function tests, chest x-ray, FVC less than 80 per cent, and hematological parameters showed no distinct pattern. A concomitant mortality study has been mounted and is in progress. PMID:1026403

  18. [Clinical study on cefprozil in pediatrics].

    PubMed

    Iwai, N; Miyazu, M; Nakamura, H; Kasai, K

    1992-11-01

    Clinical efficacy and safety of cefprozil (CFPZ, BMY-28100), a newly developed oral cephalosporin, were studied in our pediatric department. Clinical effectiveness, bacteriological effectiveness and side effects were studied in 116 pediatric patients with ages ranging 4 months to 11 years. CFPZ was given 4.6-14.1 mg/kg daily in 3 times for 3-10 days. Clinical efficacies were evaluated in 112 patients, and the therapeutic effectiveness were excellent in 1 and good in 6 for 7 patients with acute pharyngitis, excellent in 24 and good in 26 for acute purulent tonsillitis, excellent in 3, good in 8 and fair in 1 for acute bronchitis, excellent in 21, good in 7, fair in 1 and poor in 1 for acute pneumonia, excellent in 1 acute purulent parotitis, excellent in 2 and good in 7 for acute UTI, good in 1 impetigo, fair in 1 periproctal abscess and good in 1 acute enteritis. The effectiveness rate was 96.4%. Bacteriologically, 4 strains of Staphylococcus aureus (beta-lactamase producing strains), 1 strain of Staphylococcus epidermidis (beta-lactamase producing strain), 2 strains of Streptococcus pneumoniae, 2 strains of Streptococcus agalactiae, 4 strains of beta-Streptococcus, 1 strain of Klebsiella pneumoniae (beta-lactamase producing strain) and 1 strain of Salmonella C2 were all disappeared, and of 22 strains of Streptococcus pyogenes, 20 strains were disappeared, 1 was decreased and 1 was unknown, of 5 strains of Escherichia coli (3 beta-lactamase producing strains), 4 were disappeared and 1 was decreased, of 29 strains of Haemophilus influenzae (14 beta-lactamase producing strains), 14 were disappeared, 11 were decreased, 3 persisted and 1 was unknown and of 2 strains of Haemophilus parainfluenzae (1 beta-lactamase producing strain), 1 was disappeared and 1 persisted. The bacteriological eradication rates for Gram-positive bacteria and Gram-negative bacteria were 97.1% and 56.8%, respectively, and the drug was especially effective against Gram-positive bacteria. No side

  19. Economic Evaluation alongside Multinational Studies: A Systematic Review of Empirical Studies

    PubMed Central

    Oppong, Raymond; Jowett, Sue; Roberts, Tracy E.

    2015-01-01

    Purpose of the study This study seeks to explore methods for conducting economic evaluations alongside multinational trials by conducting a systematic review of the methods used in practice and the challenges that are typically faced by the researchers who conducted the economic evaluations. Methods A review was conducted for the period 2002 to 2012, with potentially relevant articles identified by searching the Medline, Embase and NHS EED databases. Studies were included if they were full economic evaluations conducted alongside a multinational trial. Results A total of 44 studies out of a possible 2667 met the inclusion criteria. Methods used for the analyses varied between studies, indicating a lack of consensus on how economic evaluation alongside multinational studies should be carried out. The most common challenge appeared to be related to addressing differences between countries, which potentially hinders the generalisability and transferability of results. Other challenges reported included inadequate sample sizes and choosing cost-effectiveness thresholds. Conclusions It is recommended that additional guidelines be developed to aid researchers in this area and that these be based on an understanding of the challenges associated with multinational trials and the strengths and limitations of alternative approaches. Guidelines should focus on ensuring that results will aid decision makers in their individual countries. PMID:26121465

  20. Oncolysis by paramyxoviruses: preclinical and clinical studies

    PubMed Central

    Matveeva, Olga V; Guo, Zong S; Senin, Vyacheslav M; Senina, Anna V; Shabalina, Svetlana A; Chumakov, Peter M

    2015-01-01

    Preclinical studies demonstrate that a broad spectrum of human malignant cells can be killed by oncolytic paramyxoviruses, which include cells of ecto-, endo-, and mesodermal origin. In clinical trials, significant reduction in size or even complete elimination of primary tumors and established metastases are reported. Different routes of viral administration (intratumoral, intravenous, intradermal, intraperitoneal, or intrapleural), and single- versus multiple-dose administration schemes have been explored. The reported side effects are grade 1 and 2, with the most common among them being mild fever. Some advantages in using paramyxoviruses as oncolytic agents versus representatives of other viral families exist. The cytoplasmic replication results in a lack of host genome integration and recombination, which makes paramyxoviruses safer and more attractive candidates for widely used therapeutic oncolysis in comparison with retroviruses or some DNA viruses. The list of oncolytic paramyxovirus representatives includes attenuated measles virus (MV), mumps virus (MuV), low pathogenic Newcastle disease (NDV), and Sendai (SeV) viruses. Metastatic cancer cells frequently overexpress on their surface some molecules that can serve as receptors for MV, MuV, NDV, and SeV. This promotes specific viral attachment to the malignant cell, which is frequently followed by specific viral replication. The paramyxoviruses are capable of inducing efficient syncytium-mediated lyses of cancer cells and elicit strong immunomodulatory effects that dramatically enforce anticancer immune surveillance. In general, preclinical studies and phase 1–3 clinical trials yield very encouraging results and warrant continued research of oncolytic paramyxoviruses as a particularly valuable addition to the existing panel of cancer-fighting approaches. PMID:26640815

  1. Electronic Structures of Anti-Ferromagnetic Tetraradicals: Ab Initio and Semi-Empirical Studies.

    PubMed

    Zhang, Dawei; Liu, Chungen

    2016-04-12

    The energy relationships and electronic structures of the lowest-lying spin states in several anti-ferromagnetic tetraradical model systems are studied with high-level ab initio and semi-empirical methods. The Full-CI method (FCI), the complete active space second-order perturbation theory (CASPT2), and the n-electron valence state perturbation theory (NEVPT2) are employed to obtain reference results. By comparing the energy relationships predicted from the Heisenberg and Hubbard models with ab initio benchmarks, the accuracy of the widely used Heisenberg model for anti-ferromagnetic spin-coupling in low-spin polyradicals is cautiously tested in this work. It is found that the strength of electron correlation (|U/t|) concerning anti-ferromagnetically coupled radical centers could range widely from strong to moderate correlation regimes and could become another degree of freedom besides the spin multiplicity. Accordingly, the Heisenberg-type model works well in the regime of strong correlation, which reproduces well the energy relationships along with the wave functions of all the spin states. In moderately spin-correlated tetraradicals, the results of the prototype Heisenberg model deviate severely from those of multi-reference electron correlation ab initio methods, while the extended Heisenberg model, containing four-body terms, can introduce reasonable corrections and maintains its accuracy in this condition. In the weak correlation regime, both the prototype Heisenberg model and its extended forms containing higher-order correction terms will encounter difficulties. Meanwhile, the Hubbard model shows balanced accuracy from strong to weak correlation cases and can reproduce qualitatively correct electronic structures, which makes it more suitable for the study of anti-ferromagnetic coupling in polyradical systems. PMID:26963572

  2. Wertheim's hypothesis on 'highway hypnosis': empirical evidence from a study on motorway and conventional road driving.

    PubMed

    Cerezuela, Gemma Pastor; Tejero, Pilar; Chóliz, Mariano; Chisvert, Mauricio; Monteagudo, M José

    2004-11-01

    This paper aims to study the phenomenon known as 'highway hypnosis' or 'driving without attention mode', which has been defined as a state showing sleepiness signs and attention slip resulting from driving a motor vehicle for a long period in a highly predictable environment with low event occurrence, this being the case with motorways and very familiar roads [Highway hypnosis: a theoretical analysis. In: Gale, A.G., Brown, I.D., Haslegrave, C.M., Moorhead, I., Taylor, S. (Eds.), Vision in Vehicles-III. Elsevier, North-Holland, pp. 467-472]. According to Wertheim's hypothesis on 'highway hypnosis', long-term driving on motorways and conventional roads, e.g. main roads, secondary roads--implies differences in the predictability of the movement pattern of the visual stimulation, in the eye musculature activity and in the type of feedback used in visual information processing (mostly extra-retinal on motorways and retinal and extra-retinal on conventional roads). All this ultimately leads to alertness differences between both road types. Our research is intended to provide empirical evidence from the hypothesis, based on the data recorded during the actual driving experience of a group of subjects on a motorway and a conventional road. We studied whether or not significant alertness differences were found-measured by EEG data relative to time periods of on-target eye-tracking performance--between motorway and conventional road driving. Our results partially support the hypothesis, as drowsiness proved to be higher on motorways than on conventional roads during the final driving period but not during the starting stage, when the opposite trend was noticed. This result could be explained by the fact that during the first driving periods the effects of the stimulus movement predictability had not yet become apparent, since they tend to show after a long drive. PMID:15350881

  3. The Dysregulation Profile in Young Children: Empirically-Defined Classes in the Generation R Study

    PubMed Central

    Basten, Maartje M. G. J.; Althoff, Robert R.; Tiemeier, Henning; Jaddoe, Vincent W. V.; Hofman, Albert; Hudziak, James J.; Verhulst, Frank C.; van der Ende, Jan

    2013-01-01

    Objective Children with co-occurring internalizing and externalizing problems have higher levels of impairment and worse outcomes later in life, but it is unclear whether these children can be distinguished validly from children who have problems in a single domain. We used a person-centered statistical approach to examine whether a group of children with co-occurring internalizing and externalizing problems can be identified in a general-population sample of young children. Method This study included a population-based sample of 6,131 children, aged 5 to 7 years. Mothers (92.6%) reported emotional and behavioral problems using the Child Behavior Checklist/1.5–5 (CBCL). A latent profile analysis was performed on the CBCL syndrome scales. Identified classes were compared on early socioeconomic and parental risk factors using multinomial logistic regression. Results We identified 4 classes: 1) a class scoring high on all internalizing and externalizing scales (1.8%), 2) a class with internalizing problems (5.3%), 3) a class with externalizing problems and emotional reactivity (7.3%), and 4) a class without problems (85.6%). The first class, with co-occurring problems, was associated with higher levels of maternal and paternal affective symptoms and hostility than the other 3 classes. Conclusions The class with co-occurring internalizing and externalizing problems appears to be highly similar to the CBCL Dysregulation Profile described in older children. This empirically-based dysregulation profile offers a promise to the study of the development of poor self-regulation. PMID:23880494

  4. Hourly Precipitation Downscaling With Empirical Statistical Methods: Case Study near the US Eastern Coast

    NASA Astrophysics Data System (ADS)

    Wang, Y.; Sivandran, G.

    2014-12-01

    Statistical downscaling methods are widely used to reconcile the spatial and temporal difference between climate model outputs and input requirements of climate change impact assessments. Quantile-mapping, due to its simplicity and general good performance, is one of the most popular. However, its simplicity also leads to variations in the procedure among studies, and it is not always well cross-validated. There is also less attention paid to sub-daily precipitation downscaling which is important for urban hydrologic purposes. The study explores the potential of quantile-mapping by comparing four of its variations, and extends its application by linking it to an hourly k nearest-neighbor resampling disaggregation. The methods are trained with NCEP/NCAR 40-year reanalysis. Seven-fold cross-validation on various mean, variability, and extreme precipitation statistics is performed with hourly observations at rain gauges along the eastern coast of the United States. The best performance on mean monthly precipitation and annual maximum 5-day precipitation is found when quantile-mapping is trained without regard to seasonality. However, the best performance on all other statistics is contingent upon the method being trained separately for each month and combined with a monthly bias-correction factor. Deficiencies in quantile-mapping carry over to the hourly disaggregation step. When the downscaled daily precipitation is satisfactory, the hourly disaggregation performs very well on all statistics after careful selection of its two parameters. These results demonstrate the importance to consider seasonality in the implementation of quantile-mapping and highlight some clear, though limited, deficiencies. That it is feasible to generate realistic hourly precipitation series with easy-to-implement empirical methods is also of interest to water managers.

  5. Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies

    PubMed Central

    Page, Matthew J.; Higgins, Julian P. T.; Clayton, Gemma; Sterne, Jonathan A. C.; Hróbjartsson, Asbjørn; Savović, Jelena

    2016-01-01

    Objective To synthesise evidence on the average bias and heterogeneity associated with reported methodological features of randomized trials. Design Systematic review of meta-epidemiological studies. Methods We retrieved eligible studies included in a recent AHRQ-EPC review on this topic (latest search September 2012), and searched Ovid MEDLINE and Ovid EMBASE for studies indexed from Jan 2012-May 2015. Data were extracted by one author and verified by another. We combined estimates of average bias (e.g. ratio of odds ratios (ROR) or difference in standardised mean differences (dSMD)) in meta-analyses using the random-effects model. Analyses were stratified by type of outcome (“mortality” versus “other objective” versus “subjective”). Direction of effect was standardised so that ROR < 1 and dSMD < 0 denotes a larger intervention effect estimate in trials with an inadequate or unclear (versus adequate) characteristic. Results We included 24 studies. The available evidence suggests that intervention effect estimates may be exaggerated in trials with inadequate/unclear (versus adequate) sequence generation (ROR 0.93, 95% CI 0.86 to 0.99; 7 studies) and allocation concealment (ROR 0.90, 95% CI 0.84 to 0.97; 7 studies). For these characteristics, the average bias appeared to be larger in trials of subjective outcomes compared with other objective outcomes. Also, intervention effects for subjective outcomes appear to be exaggerated in trials with lack of/unclear blinding of participants (versus blinding) (dSMD -0.37, 95% CI -0.77 to 0.04; 2 studies), lack of/unclear blinding of outcome assessors (ROR 0.64, 95% CI 0.43 to 0.96; 1 study) and lack of/unclear double blinding (ROR 0.77, 95% CI 0.61 to 0.93; 1 study). The influence of other characteristics (e.g. unblinded trial personnel, attrition) is unclear. Conclusions Certain characteristics of randomized trials may exaggerate intervention effect estimates. The average bias appears to be greatest in trials of

  6. Perspectives of clinical genetics professionals toward genome sequencing and incidental findings: A survey study

    PubMed Central

    Lemke, AA; Bick, D; Dimmock, D; Simpson, P; Veith, R

    2013-01-01

    The introduction of clinical genome-wide sequencing raises complex issues regarding the management of incidental findings. However, there is a lack of empirical studies assessing views of providers involved in potential disclosure of such findings. In an anonymous survey of 279 clinical genetics professionals, we found that the vast majority agreed they were interested in knowing about clinically actionable incidental findings in themselves (96%) and their child (99%), and they reported that these types of findings should be disclosed in adult (96%) and minor (98%) patients. Approximately three-fourths agreed they were personally interested in knowing about an adult-onset clinically actionable disease (78%), and a childhood-onset non-clinically actionable disease (75%) in their child. A similar percentage of participants (70%) felt these two types of findings should be disclosed to patients. Forty-four percent wanted to know about an incidental finding that indicates an adult-onset non-clinically actionable condition in themselves and 31% wanted to know about this type of information in their child. Findings from this study revealed participant views highly dependent on clinical actionability. Further research is needed with a broader population of geneticists to increase generalizability, and with diverse patients to assess their perspectives about results disclosure from clinical sequencing. PMID:23163796

  7. Uremic pruritus. Clinical and experimental studies.

    PubMed

    Ståhle-Bäckdahl, M

    1989-01-01

    The aim of the study was to investigate clinical aspects of pruritus in maintenance hemodialysis patients and to evaluate factors of putative pathogenic importance. 60-65% of the patients in a maintenance hemodialysis program during a two-year period suffered from itching. Patients with pruritus tended to have been on dialysis treatment longer than those without pruritus (p = 0.05), otherwise there was no difference in clinical data or routine laboratory tests. Measurement of itch intensity continuously over one week in 28 patients using a computerized method showed that itching peaked at night after two days without dialysis, was relatively high during treatment and lowest during the day following dialysis. Our results suggest that the accumulation of pruritogens between dialysis sessions influences the intensity of itching. Most patients had "dry" skin. Recording of the stratum corneum water content by measurement of electrical capacitance, in 31 patients (19 with pruritus) and 12 controls, disclosed no significant difference between dialysis patients and controls, but a tendency that pruritic patients had a lower water content than the other subjects. In different body areas, there was a positive correlation in all groups between the clinical estimation of xerosis and hydration. Serum concentrations of parathyroid hormone (PTH) were significantly higher in dialysis patients with pruritus than in those without, but there was no correlation between the degree of symptoms and the PTH level. Indirect immunohistochemistry revealed no immunoreactivity for different parts of the PTH molecule in skin biopsies from uremic patients. Intradermal injections of PTH fragments did not evoke itching or other cutaneous reactions in patients or controls. Our results do not support PTH as a peripheral mediator of uremic itching. Flare reactions induced by intradermal histamine injections were significantly smaller in 26 dialysis patients (18 with pruritus) than in 9 healthy

  8. Treatment of Onychomycosis – a Clinical Study

    PubMed Central

    Pajaziti, Laura; Vasili, Ermira

    2015-01-01

    Introduction: Onychomycosis is a fungal infection of the nail unit. Anatomical and physiological characteristics of the nail apparatus impose the need for long-term treatment to achieve complete cure. Goal: The main goal of this project is to study the effectiveness of several treatment protocols for onychomycosis based on Scoring Clinical Index for Onychomycosis (SCIO). Material and methods: The study included 133 patients with onychomycosis, diagnosed by KOH microscopy and culture. Based on disease severity, patients were grouped into groups with SCIO values: 6-9, and 12-16. These groups were randomly subdivided to 5 subgroups according to the given treatment protocols: fluconazole 150 mg 1x weekly, itraconazole continual therapy, itraconazole pulse therapy, terbinafine 250 mg/d, and terbinafine + ciclopirox 8% lacquer, respectively. The cure rate was evaluated at the end of 48 week. Results: The obtained cure rates according to the above mentioned protocols were: 92.30%, 81.81%, 83.33%, 90.90%, and 100%, respectively for groups of patients with SCIO values 6 – 9. Within patients with SCIO values 12-16, were achieved cure rates as follows: 78.57%, 78.57%, 75%, 80%, and 86.66%. Conclusions: There was no statistically significant difference in cure rate between five treatment protocols applied in this study. In patients with high SCIO values is expected a decrease in cure rate. PMID:26261386

  9. Erythroderma: A clinical study of 97 cases

    PubMed Central

    Akhyani, Maryam; Ghodsi, Zahra S; Toosi, Siavash; Dabbaghian, Hossein

    2005-01-01

    Background Erythroderma is a rare skin disorder that may be caused by a variety of underlying dermatoses, infections, systemic diseases and drugs. Methods We reviewed the clinical, laboratory and biopsy material of 97 patients diagnosed with erythroderma who were treated in our department over a 6-year period (1996 through 2002). Results The male-female ratio was 1.85:1. The mean age at diagnosis was 46.2 years. The most common causative factors were dermatoses (59.7%), followed by drug reactions (21.6%), malignancies (11.3%) and idiopathic causes (7.2%). Carbamazepine was the most common drug (57.1%). The best clinicopathologic correlation was found in cutaneous T-cell lymphoma and pityriasis rubra pilaris related erythroderma. Apart from scaling and erythema that were present in all patients, pruritus was the most common finding (97.5%), followed by fever (33.6%), lymphadenopathy (21.3%), edema (14.4%) and hyperkeratosis (7.2%). Conclusion This study outlines that underlying etiologic factors of erythroderma may show geographic variations. Our series had a high percentage of erythroderma secondary to preexisting dermatoses and a low percentage of idiopathic cases. There was no HIV-infected patient among our series based on multiple serum antibody tests. The clinical features of erythroderma were identical, irrespective of the etiology. The onset of the disease was usually insidious except in drug-induced erythroderma, where it was acute. The group associated with the best prognosis was that related to drugs. PMID:15882451

  10. An Empirical Study of Block Matching Techniques for the Detection of Moving Objects

    SciTech Connect

    Love, N S; Kamath, C

    2006-01-09

    The basis of surveillance, event detection, and tracking applications is the detection of moving objects in complex scenes. Complex scenes are difficult to analyze because of camera noise and lighting conditions. Currently, moving objects are detected primarily using background subtraction. We analyze block matching as an alternative for detecting moving objects. Block matching has been extensively utilized in compression algorithms for motion estimation. Besides detection of moving objects, block matching also provides motion vectors (location of motion) which can aide in tracking objects. Block matching techniques consist of three main components: block determination, search methods, and matching criteria. We compare various options for each of the components with moving object detection as the performance goal. Publicly available sequences of several different traffic and weather conditions are used to evaluate the techniques. A coherence metric and the average magnitude of object motion vector error are used to evaluate block determination approaches and search methods. To compare the matching criteria we use precision-recall curves to evaluate the performance of motion detection. We present an empirical study of the block matching techniques using these metrics of performance as well as process timing. We found the hierarchical block determination approach has an overall higher coherence of object motion vectors than the simple block determination approach, but with a significant increase in process timing. The average magnitude of object motion vector for the search methods evaluated were comparable, with the cross search method having a better coherence of object motion vectors. Overall the three step search (TSS) detects more moving objects than the cross and 2D-logarithmic search methods. And the mean square difference (MSD) matching criterion has the best precision-recall as well as process timing when using zero motion biasing.

  11. Organizational performance, Marketing strategy, and Financial strategic alignment: an empirical study on Iranian pharmaceutical firms

    PubMed Central

    2013-01-01

    Background Strategic Functional-level planning should be aligned with business level and other functional strategies of a company. It is presumed that assimilating the strategies could have positive contribution to business performance, in this regard alignment between marketing strategy and financial strategy seems to be the most important strategies being studied. An empirical work in generic pharmaceutical manufacturing companies for evaluating effect of alignment between these two functions on organizational performance was developed in this paper. Methods All Iranian pharmaceutical generic manufactures listed in Tehran stock market have been tested for period of five years between 2006–2010 and their marketing strategies were determined by using Slater and Olson taxonomy and their financial strategies have been developed by calculating total risk and total return of sample companies for five years based on rate of risk and return in the frame of a 2 × 2 matrix. For the business performance three profitability indices including Q-Tubin (Rate of market value to net asset value), ROA (Return on Asset), ROE (Return on Equity) have been tested. For analysis, a series of one-way ANOVAs as a collection of statistical models within marketing strategies considering financial strategy as independent variable and the three performance measures as dependent variables was used. Results Results show strategic alignment between financial and marketing has significant impact on profitability of company resulting in arise of all three profitability indices. Q tubing’s rate were 2.33,2.09,2.29,2.58 and rate of ROA were 0.21,0.194,0.25,0.22 and rate of ROE were 0.44,0.46,0.45,0.42 for matched strategy types, respectively the rates shown here are more than average meaning that specific type of marketing strategy is fitted with specific type of financial strategy. Conclusion Managers should not consider decisions regarding marketing strategy independently of their financial

  12. Factors Influencing Beliefs for Adoption of a Learning Analytics Tool: An Empirical Study

    ERIC Educational Resources Information Center

    Ali, Liaqat; Asadi, Mohsen; Gasevic, Dragan; Jovanovic, Jelena; Hatala, Marek

    2013-01-01

    Present research and development offer various learning analytics tools providing insights into different aspects of learning processes. Adoption of a specific tool for practice is based on how its learning analytics are perceived by educators to support their pedagogical and organizational goals. In this paper, we propose and empirically validate…

  13. Threats and Aggression Directed at Soccer Referees: An Empirical Phenomenological Psychological Study

    ERIC Educational Resources Information Center

    Friman, Margareta; Nyberg, Claes; Norlander, Torsten

    2004-01-01

    A descriptive qualitative analysis of in-depth interviews involving seven provincial Soccer Association referees was carried out in order to find out how referees experience threats and aggression directed to soccer referees. The Empirical Phenomenological Psychological method (EPP-method) was used. The analysis resulted in thirty categories which…

  14. Assessment of reforms in the electricity supply industry: A review of some recent empirical studies

    SciTech Connect

    Peerbocus, Nash

    2007-03-15

    An empirical review suggests that progress has been made in bringing competition into the inherently complex and challenging electricity market, generating substantial efficiency gains. But the large disconnect between the wholesale and retail markets indicates that much effort is needed to allow consumers to optimally reap those gains. (author)

  15. Bayes and Empirical Bayes Shrinkage Estimation of Regression Coefficients: A Cross-Validation Study.

    ERIC Educational Resources Information Center

    Nebebe, Fassil; Stroud, T. W. F.

    1988-01-01

    Bayesian and empirical Bayes approaches to shrinkage estimation of regression coefficients and uses of these in prediction (i.e., analyzing intelligence test data of children with learning problems) are investigated. The two methods are consistently better at predicting response variables than are either least squares or least absolute deviations.…

  16. Understanding Participation in E-Learning in Organizations: A Large-Scale Empirical Study of Employees

    ERIC Educational Resources Information Center

    Garavan, Thomas N.; Carbery, Ronan; O'Malley, Grace; O'Donnell, David

    2010-01-01

    Much remains unknown in the increasingly important field of e-learning in organizations. Drawing on a large-scale survey of employees (N = 557) who had opportunities to participate in voluntary e-learning activities, the factors influencing participation in e-learning are explored in this empirical paper. It is hypothesized that key variables…

  17. Success After Graduation. A Study of the Baccalaureate Graduates of Empire State College.

    ERIC Educational Resources Information Center

    Lehmann, Timothy

    Empire State College (ESC) has an interest in following the progress of its recent graduates in the world of work as well as discovering what happens to those graduates wishing to continue their education. To obtain this information a survey was conducted of all graduates and additional data analyzed that was contained in each graduate's file.…

  18. Empirical Studies of Interactions of Semantic Roles: The Agent and Patient in Mandarin Chinese

    ERIC Educational Resources Information Center

    Yue, Kun

    2010-01-01

    This dissertation investigates the interaction between form and function in Mandarin Chinese by empirically examining the interactions of core semantic roles (Agent and Patient) and the syntactic representation of those interactions in semantically transitive events. First, I demonstrate that syntactic structures and functions are intertwined with…

  19. Developmental Relationship Programs: An Empirical Study of the Impact of Peer-Mentoring Programs

    ERIC Educational Resources Information Center

    Shojai, Siamack; Davis, William J.; Root, Patricia S.

    2014-01-01

    This paper provides an empirical analysis of the impact and effectiveness of developmental relationships provided through academic intervention programs at a medium-size master's level public university in the Northeastern United States. The programs' curriculum follows the Model of Strategic Learning's four pillars of learning and is administered…

  20. School-Based Management and Paradigm Shift in Education an Empirical Study

    ERIC Educational Resources Information Center

    Cheng, Yin Cheong; Mok, Magdalena Mo Ching

    2007-01-01

    Purpose: This paper aims to report empirical research investigating how school-based management (SBM) and paradigm shift (PS) in education are closely related to teachers' student-centered teaching and students' active learning in a sample of Hong Kong secondary schools. Design/methodology/approach: It is a cross-sectional survey research…

  1. Indigenous People and Poverty in Latin America: An Empirical Analysis. World Bank Regional and Sectoral Studies.

    ERIC Educational Resources Information Center

    Psacharopoulos, George, Ed.; Patrinos, Harry Anthony, Ed.

    The indigenous peoples of Latin America live in conditions of extreme poverty. This book uses empirical data from national survey sources to determine the extent of poverty among Latin American indigenous populations; to compare indigenous and nonindigenous populations with regard to socioeconomic status, living conditions, educational attainment,…

  2. Clinical study of the stunned myocardium.

    PubMed

    Sone, T; Tsuboi, H; Sassa, H

    1991-09-01

    Clinical features of 37 cases of stunned myocardium were studied. Mean duration of asynergy was 22.6 +/- 15.7 days. In all 11 cases of unstable angina without any significant serum creatine kinase leakage, the duration of asynergy was within 14 days. Related coronary lesions were reperfused (spontaneously or by interventional therapy) to TIMI grade II or higher. Transient Q waves were observed in 39% of all cases. Negative T waves tended to be prolonged, and persisted after disappearance of asynergy in 74% of all cases. 201Tl uptake in the stunned area varied widely between individual cases (ranging from "absent" to "normal"), although it became normal in all cases in the chronic stage. Mal-distribution of 99mTc-pyrophosphate (PYP) to the endocardial side of the stunned area was observed in 33%. In 186 cases of acute coronary syndrome, we studied whether or not reversibility of ischemia-disturbed myocardium could be predicted by simultaneous dual isotope SPECT, and found that 201Tl-uptake in the chronic stage significantly improved in the region showing absence of 99mTc-PYP accumulation or maldistribution of 99mTc-PYP to the endocardial side, while reversibility of the region showing transmural 99mTc-PYP accumulation and a dought pattern was poor. Ischemia-associated myocardial damage recovered to various degrees, and dual isotope SPECT was useful in evaluating the reversibility of such damage already at the acute stage. PMID:1834873

  3. Bioplastique at 6 years: clinical outcome studies.

    PubMed

    Ersek, R A; Gregory, S R; Salisbury, A V

    1997-11-01

    Bioplastique is a biphasic polymer for the permanent augmentation of some soft tissues. It was developed in 1987, and clinical studies at this institution were begun in 1990. The combination of low molecular weight polyvinylpyrrolidone and solid polymer particles allows the implantation of permanent polymer spheres through a small needle under local anesthesia. In this study 127 cases are reviewed of consecutive patients who have received Bioplastique for scar revision, wrinkles, and augmentation for soft-tissue defects at 6 years after application. All patients who had not been in for follow-up recently were contacted by mail and questioned on the permanence of augmentation and migration of particles. About 30 percent of the patients were unreachable and had their charts reviewed for permanence and migration of particles. In eight of these cases, Bioplastique was removed because of overcorrection, two of them may have had infection. Bioplastique has gained wide use throughout the world and although some complications have been reported, in general, it functions quite well when used in selected cases. PMID:9385974

  4. [Clinical and histopathologic study of salivary mucoceles].

    PubMed

    Kang, S K; Kim, K S

    1989-11-01

    Mucoceles are commonly occurring lesions of the oral mucous membrane and the most common lesion involving minor salivary tissue. The incidence of mucoceles is understandable since accessary salivary gland tissue is widely distributed throughout the oral mucous membrane and trauma to the mucosa, which causes their formation, occurs frequently. But only a few studies have been reported that describe its detailed features. This is a retrospective study on the salivary mucoceles in the oral mucous membrane and based on clinical chart, biopsy request and photomicroscopic finding of 112 patients treated by Dept. of Oral Surgery in Seoul National University Hospital, during the period of last 10 years. The results were as following. 1. The age range of the 112 patients was 2 to 60 years, with a peak incidence in the second decade and a gradual decline thereafter. Of the 112 patients, 49 (44%) were males and 63 (56%) were females, the male-to-female ratio being 1:1.29. 2. The majority of these lesions were located on the lower lip but occurred with lesser frequently on the buccal mucosa, floor of the mouth, tongue, retromolar region, upper lip. 3. Of the 112 patients, 107 (95%) were treated by excision and only 5 were treated by marsupialization. 18 of 112 cases had recurrence and the recurrence rate in this study was 16%. 4. Only 3 of the 112 cases revealed an epithelial lining. This incidence indicates that the mucus-extravasation by the damage of excretory duct rather than the ductal dilatation by mucus-retention may play a critical role in the production of these lesions. 5. In 81 cases (72.3%) minor salivary gland were included in the excision biopsy, specimen. Changes observed in the glandular tissue were atrophy and infiltration of chronic inflammatory cell, but the secretory function of gland was thought to be normal in most cases because the changes were mild. PMID:2489621

  5. Narrowing the Skills Gap for Innovation: An Empirical Study in the Hospital Sector

    PubMed Central

    Escoval, Ana

    2014-01-01

    Background The current financial crisis and the increasing burden of chronic diseases are challenging hospitals to enhance their innovation capacity to deliver new and more effective health services. However, the shortage of skills has been widely recognized as a key obstacle for innovation. Ensuring the presence of a skilled workforce has become a priority for the health system in Portugal and across Europe. Objective The aim of this study was to examine the demand of new skills and their influence in both investments in innovation and development of skills. Methods We used a mixed-methods approach combining statistical analysis of data survey and content analysis of semistructured interviews with the Administration Boards of hospitals, using a nominal group technique. Results The results illustrate an increasing demand of a broad range of skills for innovation development, including responsibility and quality consciousness (with a significant increase of 55%, 52/95), adaptation skills (with an increase of 44%, 42/95) and cooperation and communication skills (with an increase of 55%, 52/95). Investments in the development of skills for innovation are mainly focused on aligning professional training with an organizational strategy (69%, 66/95) as well as collaboration in taskforces (61%, 58/95) and cross-department teams (60%, 57/95). However, the dynamics between the supply and demand of skills for innovation are better explained through a broader perspective of organizational changes towards enhancing learning opportunities and engagement of health professionals to boost innovation. Conclusions The results of this study illustrate that hospitals are unlikely to enhance their innovation capacity if they pursue strategies failing to match the skills needed. Within this context, hospitals with high investments in innovation tend to invest more in skills development. The demand of skills and investments in training are influenced by many other factors, including the

  6. An empirical study of the nuclear explosion-induced lightning seen on IVY-MIKE

    NASA Astrophysics Data System (ADS)

    Colvin, J. D.; Mitchell, C. K.; Greig, J. R.; Murphy, D. P.; Pechacek, R. E.; Raleigh, M.

    1987-05-01

    We report the results of a unique study of the lightninglike phenomena that were seen to accompany the MIKE shot of operation IVY on October 31 1952. MIKE was a thermonuclear surface burst yielding 10.4 MT, which took place on Enewetak Atoll. During the period of approximately 10 ms after detonation, five discrete luminous channels were seen to start from the ground or sea surface at a distance of approximately 1 km from the burst point and to grow up into the clouds. We have reexamined the original photographic records of IVY-MIKE, obtaining effective brightnesses (optical powers per unit length) for the luminous channels at different altitudes as functions of time. The absolute calibration for the MIKE records was deduced by comparison with the photographic records of other events of that era, laboratory measurements of film sensitivity, and use of atmospheric transmission data taken just prior to the MIKE event. Errors in this analysis lead to an uncertainty of a factor of ˜2 in the brightnesses of the luminous channels. In the laboratory we have used laser-guided electric discharges to create long (100 cm), arclike plasma channels to simulate the observed luminous channels and to allow determination of an empirical relation between the brightness of the channel and the electric current flowing in the channel. These laboratory discharges had peak currents up to 100 kA and periods of ˜2 ms. Spectroscopic analysis showed that the luminous channels consisted primarily of normal air plasma with typical ground-level contaminants. Photographic studies showed that these long-duration discharges are unstable to the m = 1 magnetohydrodynamic (MHD) instability and become severely distorted in less than 1 ms. By direct comparison of the luminous channels seen at MIKE and the laboratory discharges, we deduce: (1) the peak current in the prominent (brightest) channel at MIKE was between 200 and 600 kA. Here the most likely value of the peak current was 250±50 kA, but

  7. Using Clinical Gait Case Studies to Enhance Learning in Biomechanics

    ERIC Educational Resources Information Center

    Chester, Victoria

    2011-01-01

    Clinical case studies facilitate the development of clinical reasoning strategies through knowledge and integration of the basic sciences. Case studies have been shown to be more effective in developing problem-solving abilities than the traditional lecture format. To enhance the learning experiences of students in biomechanics, clinical case…

  8. Forecasting Energy Market Contracts by Ambit Processes: Empirical Study and Numerical Results

    PubMed Central

    Di Persio, Luca; Marchesan, Michele

    2014-01-01

    In the present paper we exploit the theory of ambit processes to develop a model which is able to effectively forecast prices of forward contracts written on the Italian energy market. Both short-term and medium-term scenarios are considered and proper calibration procedures as well as related numerical results are provided showing a high grade of accuracy in the obtained approximations when compared with empirical time series of interest. PMID:27437500

  9. An empirical, graphical, and analytical study of the relationship between vegetation indices. [derived from LANDSAT data

    NASA Technical Reports Server (NTRS)

    Lautenschlager, L.; Perry, C. R., Jr. (Principal Investigator)

    1981-01-01

    The development of formulae for the reduction of multispectral scanner measurements to a single value (vegetation index) for predicting and assessing vegetative characteristics is addressed. The origin, motivation, and derivation of some four dozen vegetation indices are summarized. Empirical, graphical, and analytical techniques are used to investigate the relationships among the various indices. It is concluded that many vegetative indices are very similar, some being simple algebraic transforms of others.

  10. An Empirical Study of the Wound Effects on Sap Flow Measured with Thermal Dissipation Probes

    NASA Astrophysics Data System (ADS)

    Wiedemann, A.; Marañón-Jiménez, S.; Herbst, M.; Cuntz, M.; Rebmann, C.

    2014-12-01

    Sap flow sensors are common to assess the contribution of tree transpiration to ecosystem evapotranspiration (ET). Thermal dissipation (TD) is one of the most popular methods for sap measurements but the insertion of TD probes in the tree stems imply wounding of the wood tissue and a consequent alteration of the sap flow. But the determination of sap flux density (SFD) is based on an empirical function developed for freshly drilled holes and it does hence not account for the wound effect. Here we investigate the effect of wound healing on sap flow measurements with TD probes. Our objectives were (1) the establishment of correction factors to account for the wound effect and (2) the determination of the point in time after installation when the correction factors become applicable. For that we performed an experiment in which TD probes were installed successively in diffuse- and ring-porous trees (Fagus sylvatica and Quercus petraea, resp.) during the growing season. The trees were logged in fall and additional sensors were installed afterwards in the logged stems. SFDs measured by the different TD sensors were compared with gravimetric estimates in the laboratory. Gravimetric flow compared well with SFD estimates from freshly installed sensors without wound formation, with only a slight underestimation by the TDs. In contrast, older sensors, submitted to wound reactions, underestimated SFD by up to 40%. However, sensors with 5, 11 and 22 week old wounds showed no significant differences, which implies that wound healing occurs in the first weeks after scission. Similar sap flow underestimations due to wound effects were observed in both species, oak and beech. This study highlights the relevance of accounting for tree wound reactions for accurate estimation of tree transpiration based on thermal dissipation sensors. We provide a correction factor for the classical Granier TD sensors that can be used from the first weeks after installation in similar species. This

  11. The study and development of the empirical correlations equation of natural convection heat transfer on vertical rectangular sub-channels

    NASA Astrophysics Data System (ADS)

    Kamajaya, Ketut; Umar, Efrizon; Sudjatmi, K. S.

    2012-06-01

    This study focused on natural convection heat transfer using a vertical rectangular sub-channel and water as the coolant fluid. To conduct this study has been made pipe heaters are equipped with thermocouples. Each heater is equipped with five thermocouples along the heating pipes. The diameter of each heater is 2.54 cm and 45 cm in length. The distance between the central heating and the pitch is 29.5 cm. Test equipment is equipped with a primary cooling system, a secondary cooling system and a heat exchanger. The purpose of this study is to obtain new empirical correlations equations of the vertical rectangular sub-channel, especially for the natural convection heat transfer within a bundle of vertical cylinders rectangular arrangement sub-channels. The empirical correlation equation can support the thermo-hydraulic analysis of research nuclear reactors that utilize cylindrical fuel rods, and also can be used in designing of baffle-free vertical shell and tube heat exchangers. The results of this study that the empirical correlation equations of natural convection heat transfer coefficients with rectangular arrangement is Nu = 6.3357 (Ra.Dh/x)0.0740.

  12. [Attempt to standardize clinical tests for the purpose of quality management in the field of clinical studies and clinical trials].

    PubMed

    Ishibashi, Midori; Komiyama, Yasushi; Furuta, Koh

    2011-10-01

    The purpose of this study was to contribute to the quality management in the fields of clinical studies and clinical trials. To accomplish this purpose we tried to make guidelines for nationwide standardization of clinical tests. This study was performed by multidisciplinary personnel such as medical doctors, medical technologist, CRC, and representatives of pharmaceutical companies and/or clinical laboratory testing companies. The study was also focused on two fields of clinical tests such as pre-analytical and post-analytical phase. Each member shared various incidents and tried to make solutions. In post-analytical area in particular, further discussion concerning CDISC and SS-MIX was done. Based on these efforts, a tentative guideline was made. PMID:22184881

  13. Ab initio molecular dynamics study of water at constant pressure using converged basis sets and empirical dispersion corrections

    NASA Astrophysics Data System (ADS)

    Ma, Zhonghua; Zhang, Yanli; Tuckerman, Mark E.

    2012-07-01

    It is generally believed that studies of liquid water using the generalized gradient approximation to density functional theory require dispersion corrections in order to obtain reasonably accurate structural and dynamical properties. Here, we report on an ab initio molecular dynamics study of water in the isothermal-isobaric ensemble using a converged discrete variable representation basis set and an empirical dispersion correction due to Grimme [J. Comp. Chem. 27, 1787 (2006)], 10.1002/jcc.20495. At 300 K and an applied pressure of 1 bar, the density obtained without dispersion corrections is approximately 0.92 g/cm3 while that obtained with dispersion corrections is 1.07 g/cm3, indicating that the empirical dispersion correction overestimates the density by almost as much as it is underestimated without the correction for this converged basis. Radial distribution functions exhibit a loss of structure in the second solvation shell. Comparison of our results with other studies using the same empirical correction suggests the cause of the discrepancy: the Grimme dispersion correction is parameterized for use with a particular basis set; this parameterization is sensitive to this choice and, therefore, is not transferable to other basis sets.

  14. Empirical treatment for TB in HIV: lessons from a cohort study of people living with HIV treated in Recife, Brazil

    PubMed Central

    2014-01-01

    Background Tuberculosis (TB) is the leading cause of death related to HIV worldwide. This study analyzes the survival of People Living with HIV (PLHIV) reporting cough without bacteriological confirmation of TB and identify factors associated with death. Methods Prospective cohort with a consecutive sample of PLHIV, aged ≥ 18 years. Patient inclusion criteria were complaint of current cough of any duration at the time of the first study interview or during their subsequent routine visits to health services and for whom AFB sputum smear was either negative or not performed during the whole follow-up period. Kaplan-Meier method was used to calculate the probability of survival. We estimated the Hazard Ratio (HR) in bivariate and multivariate Cox regression analyses. Results Mortality was 4.6 per 100 py; 73% were receiving HAART at recruitment. Average time from the first recorded date of cough until empirical treatment for tuberculosis was six months. Mortality was higher when the CD4 count was low (HR = 5.3; CI 95%: 3.2-9.0; p = 0.000), in those with anemia (HR = 3.0; CI 95%: 1.6-5.6; p = 0.001) and with abnormal chest X-rays (HR = 2.4; CI 95%: 1.4-4.0; p = 0.001). Mortality was higher in those receiving empirical TB treatment (HR = 2.4; CI 95%: 1.4-4.0; p = 0.002), but only in those with normal X-rays, no history of tuberculosis and no bacteriology requests. Empirical treatment for TB was more frequent in PLHIV with low CD4 counts, anemia, history of opportunistic infections, weight loss, previous tuberculosis, negative bacteriology test (as opposed to not having a test) and abnormal chest X-ray. Conclusions Higher mortality in PLHIV reporting a current cough without bacteriological confirmation of tuberculosis was identified for those with a CD4 cell count <200, abnormal chest X-ray, anemia and empirical treatment for tuberculosis. Mortality was not significantly higher in those empirically treated for TB, who had three

  15. Characteristics of German hospitals adopting health IT systems - results from an empirical study.

    PubMed

    Liebe, Jan-David; Egbert, Nicole; Frey, Andreas; Hübner, Ursula

    2011-01-01

    Hospital characteristics that facilitate IT adoption have been described by the literature extensively, however with controversial results. The aim of this study therefore is to draw a set of the most important variables from previous studies and include them in a combined analysis for testing their contribution as single factors and their interactions. Total number of IT systems installed and number of clinical IT systems in the hospital were used as criterion variables. Data from a national survey of German hospitals served as basis. Based on a stepwise multiple regression analysis four variables were identified to significantly explain the degree of IT adoption (60% explained variance): 1) hospital size, 2) IT department, 3) reference customer and 4) ownership (private vs. public). Our results replicate previous findings with regard to hospital size and ownership. In addition our study emphasizes the importance of a reliable internal structure for IT projects (existence of an IT department) and the culture of testing and installing most recent IT products (being a reference customer). None of the interactions between factors was significant. PMID:21893768

  16. [Clinical studies of pediatric malabsorption syndromes].

    PubMed

    Hosoyamada, Takashi

    2006-11-01

    Multiple cases with various types of pediatric malabsorption syndromes were evaluated. The clinical manifestations, laboratory findings, pathophysiology, and histopathological descriptions of each patient were analyzed in an effort to clear the pathogenesis of the malabsorption syndromes and the treatments were undertaken. The cases studied, included one patient with cystic fibrosis, two with lactose intolerance with lactosuria (Durand type), one with primary intestinal lymphangiectasia, two with familial hypobetalipoproteinemia, one with Hartnup disease, one with congenital chroride diarrhea, one with acrodermatitis enteropathica, one with intestinal nodular lymphoid hyperplasia (NLH), five with intractable diarrhea of early infancy and four with glycogenosis type Ia. Each case description and outcome is described below: 1. A 15-year-old Japanese boy with cystic fibrosis presented with severe symptoms, including pancreatic insufficiency, bronchiectasis, pneumothorax and hemoptysis. His prognosis was poor. Analysis of the CFTR genes of this patient revealed a homozygous large deletion from intron 16 to 17b. 2. In the sibling case of Durand type lactose intolerance, the subjects'disaccaridase activity of the small bowel, including lactase, were within normal limits. The results of per oral and per intraduodenal lactose tolerance tests confirmed lactosuria in both. These observations suggested, not only an abnormal gastric condition, but also duodenal and intestinal mucosal abnormal permeability of lactose. 3. In the case of primary intestinal lymphangiectasia, the subject had a lymphedematous right arm and hand, a grossly coarsened mucosal pattern of the upper gastrointestinal tract (identified via radiologic examination) and the presence of lymphangiectasia (confirmed via duodenal mucosal biopsy). The major laboratory findings were hypoalbuminemia, decreased immunoglobulin levels and lymphopenia resulting from loss of lymph fluid and protein into the gastro

  17. Pitavastatin: clinical effects from the LIVES Study.

    PubMed

    Teramoto, Tamio

    2011-11-01

    Although clinical trials provide useful information on drug safety and efficacy, results do not always reflect those observed in the real world. The Japanese long-term prospective post-marketing surveillance LIVALO Effectiveness and Safety (LIVES) Study was designed to assess the efficacy and safety of pitavastatin in clinical practice in ~20,000 patients. After 104 weeks, pitavastatin was associated with significant reductions in low-density lipoprotein-cholesterol (LDL-C) (29.1%) that largely occurred within 4 weeks of treatment initiation. In patients with abnormal triglyceride (TG) and high-density lipoprotein-cholesterol (HDL-C) levels at baseline, pitavastatin reduced TG and increased HDL-C by 22.7% and 19.9%, respectively. Overall, 88.2% of the primary prevention low-risk patients attained their Japan Atherosclerosis Society LDL-C target, compared with 82.7% of intermediate-risk patients, 66.5% of high-risk patients and 50.3% of secondary prevention patients. Only 10.4% of pitavastatin-treated patients experienced adverse events (AEs), of which approximately 84% were mild and around 1% was severe. Increases in blood creatine phosphokinase (2.7%), alanine aminotransferase (1.8%), myalgia (1.1%), aspartate aminotransferase (1.5%) and gamma-glutamyltransferase (1.0%) were the most common AEs and only 7.4% of patients discontinued pitavastatin due to AEs. Regression analysis demonstrated that age was not a significant factor for the incidence of any AE or myopathy-associated events. A subanalysis of initial LIVES data focussing on the effects of pitavastatin on HDL-C levels showed that HDL-C was elevated by 5.9% in all patients and by 24.6% in those with low (studies have shown that other statins have inconsistent effects on HDL

  18. Triptan nonresponder studies: implications for clinical practice.

    PubMed

    Dodick, David W

    2005-02-01

    The maximum absolute response rate with oral triptans, as measured in clinical trials by the incidence of relief from migraine pain at 2 hours after taking medication, is approximately 70%. Therefore around 30% of patients fail to respond to a particular triptan. Nonresponse is likely to be due to a variety of factors, including low and inconsistent absorption, use of the medication late in an attack, inadequate dosing, and variability in individual response. Evidence from recent clinical trials, however, confirms the common clinical observation that patients with a poor response to one triptan can benefit from subsequent treatment with a different triptan. Two-hour pain-relief rates of 25% to 81% using alternative triptans (naratriptan, almotriptan, eletriptan, zolmitriptan, and rizatriptan) have been reported in patients who were described as poor responders to sumatriptan. Physicians should remain vigilant in assessing the response to acute therapy and take advantage of simple clinical questionnaires that have been developed to facilitate the recognition of those patients who require and may benefit from a change in acute therapy. PMID:15705122

  19. A study of clinically related open source software projects.

    PubMed

    Hogarth, Michael A; Turner, Stuart

    2005-01-01

    Open source software development has recently gained significant interest due to several successful mainstream open source projects. This methodology has been proposed as being similarly viable and beneficial in the clinical application domain as well. However, the clinical software development venue differs significantly from the mainstream software venue. Existing clinical open source projects have not been well characterized nor formally studied so the 'fit' of open source in this domain is largely unknown. In order to better understand the open source movement in the clinical application domain, we undertook a study of existing open source clinical projects. In this study we sought to characterize and classify existing clinical open source projects and to determine metrics for their viability. This study revealed several findings which we believe could guide the healthcare community in its quest for successful open source clinical software projects. PMID:16779056

  20. SAGE II/Umkehr ozone comparisons and aerosols effects: An empirical and theoretical study. Final report

    SciTech Connect

    Newchurch, M.

    1997-09-15

    The objectives of this research were to: (1) examine empirically the aerosol effect on Umkehr ozone profiles using SAGE II aerosol and ozone data; (2) examine theoretically the aerosol effect on Umkehr ozone profiles; (3) examine the differences between SAGE II ozone profiles and both old- and new-format Umkehr ozone profiles for ozone-trend information; (4) reexamine SAGE I-Umkehr ozone differences with the most recent version of SAGE I data; and (5) contribute to the SAGE II science team.

  1. Empirical study on competition in audience rating of China Central Television programs

    NASA Astrophysics Data System (ADS)

    Wu, Lingling; Zhou, Yue-Ping; Chang, Hui; He, Da-Ren

    2007-03-01

    In recent years, the competition in audience rating of China Central Television (CCTV) Programs becomes increasingly more vehement. Each program is trying its best to figure the new view to the masses. We have performed an empirical investigation on the competition situation by using a complex network description. In the network nodes are defined as television programs. Two nodes are connected by an edge when they are positioned in a common time period. The edge represents the competition and cooperation relationship between the programs. They are competing because each of them tries to get more audience rating; they are cooperating since each of them obtains some audience rating, or say, gets ``a piece of cake.'' Some empirical statistical rules have been obtained, such as an exponential degree distribution, the average path length 1.52, the C(k) ˜k-1 scaling rule between the clustering coefficient and the degree, and the approximate zero assortativity. These observations may be helpful for the arrangement of the television programs.

  2. Pharmaceutical studies during the Second Empire in the Gaceta Médica de México.

    PubMed

    Vega Y Ortega, Rodrigo

    2016-01-26

    Pharmaceutical activities during the Second Empire have been neglected by historians of science in recent decades, even though pharmacy was an important discipline in Mexico City. This is shown by analyzing 12 papers published in the Gaceta Médica de México, the journal of the Sociedad Médica de México. Examination of these papers helps us understand the interests, practices and pharmaceutical activities of some of this group's physicians and pharmacists, as well as detailing scientific endorsement of the therapeutic use of Mexican flora. This allows us to trace a historical continuity in the activities of pharmacists in the capital city throughout the nineteenth century. Abstract Pharmaceutical activities during the Second Empire have been neglected by historians of science in recent decades, even though pharmacy was an important discipline in Mexico City. This is shown by analyzing 12 papers published in the Gaceta Médica de México, the journal of the Sociedad Médica de México. Examination of these papers helps us understand the interests, practices and pharmaceutical activities of some of this group's physicians and pharmacists, as well as detailing scientific endorsement of the therapeutic use of Mexican flora. This allows us to trace a historical continuity in the activities of pharmacists in the capital city throughout the nineteenth century. PMID:27280314

  3. Conditions for Valid Empirical Estimates of Cancer Overdiagnosis in Randomized Trials and Population Studies.

    PubMed

    Gulati, Roman; Feuer, Eric J; Etzioni, Ruth

    2016-07-15

    Cancer overdiagnosis is frequently estimated using the excess incidence in a screened group relative to that in an unscreened group. However, conditions for unbiased estimation are poorly understood. We developed a mathematical framework to project the effects of screening on the incidence of relevant cancers-that is, cancers that would present clinically without screening. Screening advances the date of diagnosis for a fraction of preclinical relevant cancers. Which diagnoses are advanced and by how much depends on the preclinical detectable period, test sensitivity, and screening patterns. Using the model, we projected incidence in common trial designs and population settings and compared excess incidence with true overdiagnosis. In trials with no control arm screening, unbiased estimates are available using cumulative incidence if the screen arm stops screening and using annual incidence if the screen arm continues screening. In both designs, unbiased estimation requires waiting until screening stabilizes plus the maximum preclinical period. In continued-screen trials and population settings, excess cumulative incidence is persistently biased. We investigated this bias in published estimates from the European Randomized Study of Screening for Prostate Cancer after 9-13 years. In conclusion, no trial or population setting automatically permits unbiased estimation of overdiagnosis; sufficient follow-up and appropriate analysis remain crucial. PMID:27358266

  4. [Clinical studies of cefoperazone in neurosurgery].

    PubMed

    Kitamura, K; Shimizu, T; Abe, H; Suzuki, J; Tanaka, R; Nagai, H; Yamamoto, S; Handa, H; Nishimoto, A; Matsuoka, K

    1986-01-01

    A multicenter trial consisting of 164 institutions through out Japan, has been conducted to study the transfer of cefoperazone (CPZ) into the cerebrospinal fluid (CSF), and the clinical effectiveness of CPZ as a therapeutic or prophylactic agent in neurosurgery. The levels of CPZ in serum and CSF were determined in 96 patients. After initial dose of 2 g CPZ (intravenous drip infusion for 30 minutes), the serum level of CPZ after 1 hour was 124.5 +/- 6.6 micrograms/ml (Mean +/- S.E.), and even after 6 hours, it maintained as high as 47.8 +/- 16.6 micrograms/ml. The peak CPZ levels in CSF in patients with normal or minimal impairment in blood-CSF-barrier (BCB) (group I) and in those of localized impairment in BCB (group II) were 1.0 +/- 0.5 micrograms/ml at 2 hours and 3.0 +/- 1.8 micrograms/ml at 3 hours, respectively. The highest CSF level was seen in patients with meningitis (group III) and showed 5.0 +/- 2.4 micrograms/ml at 6 hours. After multiple dose of 2 g CPZ (intravenous drip infusion for 30 minutes), the serum kinetics of CPZ were not significantly different from those obtained after initial dose. However, the CPZ levels in CSF were higher than those observed after initial dose in all 3 groups and were higher than MIC75 against relevant pathogens for meningitis such as Escherichia coli, Klebsiella pneumoniae and Staphylococcus aureus. Moreover, in group III peak level of CPZ in CSF exceeded the MIC75 against Pseudomonas aeruginosa which is also frequently isolated from patients with meningitis in neurosurgery. As a therapeutic agent CPZ administered as sole agent was effective in 42 out of 55 cases (76.4%) in meningitis, in 78 out of 116 cases (67.2%) in pneumonia and in 36 out of 47 cases (76.6%) in urinary tract infection (UTI). Its efficacy rate against all infections treated was 72.2% (184/255). Regarding CPZ's prophylactic use, 39 out of 514 cases (7.6%) were judged as having or possibly having infections as follows; meningitis (13/514, 2

  5. Comparative study of ECG signal denoising by wavelet thresholding in empirical and variational mode decomposition domains.

    PubMed

    Lahmiri, Salim

    2014-09-01

    Hybrid denoising models based on combining empirical mode decomposition (EMD) and discrete wavelet transform (DWT) were found to be effective in removing additive Gaussian noise from electrocardiogram (ECG) signals. Recently, variational mode decomposition (VMD) has been proposed as a multiresolution technique that overcomes some of the limits of the EMD. Two ECG denoising approaches are compared. The first is based on denoising in the EMD domain by DWT thresholding, whereas the second is based on noise reduction in the VMD domain by DWT thresholding. Using signal-to-noise ratio and mean of squared errors as performance measures, simulation results show that the VMD-DWT approach outperforms the conventional EMD-DWT. In addition, a non-local means approach used as a reference technique provides better results than the VMD-DWT approach. PMID:26609387

  6. Self-Organized Criticality and Stock Market Dynamics: an Empirical Study

    SciTech Connect

    M. Bartolozzi; D. B. Leinweber; A. W. Thomas

    2004-05-01

    The Stock Market is a complex self-interacting system, characterized by an intermittent behavior. Periods of high activity alternate with periods of relative calm. In the present work we investigate empirically about the possibility that the market is in a self-organized critical state (SOC). A wavelet transform method is used in order to separate high activity periods, related to the avalanches of sandpile models, from quiescent. A statistical analysis of the filtered data show a power law behavior in the avalanche size, duration and laminar times. The memory process, implied by the power law distribution, of the laminar times is not consistent with classical conservative models for self-organized criticality. We argue that a ''near-SOC'' state or a time dependence in the driver, which may be chaotic, can explain this behavior.

  7. Comparative study of ECG signal denoising by wavelet thresholding in empirical and variational mode decomposition domains

    PubMed Central

    2014-01-01

    Hybrid denoising models based on combining empirical mode decomposition (EMD) and discrete wavelet transform (DWT) were found to be effective in removing additive Gaussian noise from electrocardiogram (ECG) signals. Recently, variational mode decomposition (VMD) has been proposed as a multiresolution technique that overcomes some of the limits of the EMD. Two ECG denoising approaches are compared. The first is based on denoising in the EMD domain by DWT thresholding, whereas the second is based on noise reduction in the VMD domain by DWT thresholding. Using signal-to-noise ratio and mean of squared errors as performance measures, simulation results show that the VMD-DWT approach outperforms the conventional EMD–DWT. In addition, a non-local means approach used as a reference technique provides better results than the VMD-DWT approach. PMID:26609387

  8. Sports Neurology in Clinical Practice: Case Studies.

    PubMed

    Seifert, Tad

    2016-08-01

    With regard to persistent posttraumatic headache, there is legitimate concern that duration of symptoms may have an impact on the efficacy of future treatment attempts. Without neuropathologic confirmation, a clinical diagnosis of chronic traumatic encephalopathy cannot be made with a high degree of confidence. Sport-related headaches are challenging in a return-to-play context, because it is often unclear whether an athlete has an exacerbation of a primary headache disorder, has new-onset headache unrelated to trauma, or is in the recovery phase after concussion. Regular physical exercise may prove beneficial to multiple neurologic disease states. PMID:27445251

  9. A clinical study of Noonan syndrome.

    PubMed Central

    Sharland, M; Burch, M; McKenna, W M; Paton, M A

    1992-01-01

    Clinical details are presented on 151 individuals with Noonan syndrome (83 males and 68 females, mean age 12.6 years). Polyhydramnios complicated 33% of affected pregnancies. The commonest cardiac lesions were pulmonary stenosis (62%), and hypertrophic cardiomyopathy (20%), with a normal echocardiogram present in only 12.5% of all cases. Significant feeding difficulties during infancy were present in 76% of the group. Although the children were short (50% with a height less than 3rd centile), and underweight (43% with a weight less than 3rd centile), the mean head circumference of the group was on the 50th centile. Motor milestone delay was usual, the cohort having a mean age of sitting unsupported of 10 months and walking of 21 months. Abnormal vision (94%) and hearing (40%) were frequent findings, but 89% of the group were attending normal primary or secondary schools. Other associations included undescended testicles (77%), hepatosplenomegaly (50%), and evidence of abnormal bleeding (56%). The mean age at diagnosis of Noonan syndrome in this group was 9.0 years. Earlier diagnosis of this common condition would aid both clinical management and genetic counselling. Images Figure 1 Figure 2 Figure 3 PMID:1543375

  10. Document Clustering of Clinical Narratives: a Systematic Study of Clinical Sublanguages

    PubMed Central

    Patterson, Olga; Hurdle, John F.

    2011-01-01

    It is widely believed that different clinical domains use their own sublanguage in clinical notes, complicating natural language processing, but this has never been demonstrated on a broad selection of note types. Starting from formal sublanguage theory, we constructed a feature space based on vocabulary and semantic types used in 17 different clinical domains by three author types (physicians, nurses, and social workers) in both the in- and outpatient settings. We supplied the resulting vectors to CLUTO, a robust clustering tool suitable for this high-dimensional space. Our results confirm that note types with a broad clinical scope, e.g, History & Physicals and Discharge Summaries, cluster together, while note types with a narrow clinical scope form surprisingly pure, disjoint sublanguages. A reasonable conclusion from this study is that any tool relying on term statistics or semantics trained on one clinical note type may not work well on any other. PMID:22195171

  11. Congenital myopathies: clinical and immunohistochemical study.

    PubMed

    Thaha, Fazil; Gayathri, N; Nalini, A

    2011-01-01

    Congenital myopathies (CMs), a group of relatively non-progressive disorders presents with weakness and hypotonia of varying severity, morphologically recognized by specific structural abnormalities within the myofiber. This report presents the clinical and Histopathological features of 40 patients with CMs. Centronuclear myopathy was the commonest (40%) followed by congenital fiber type disproportion (37.5%). Other less common CMs included: myotubular myopathy (5%), nemaline myopathy (5%), central core disease (5%), multicore disease (2.5%) and congenital myopathy with tubular aggregate (5%). Immunolabeling to desmin corresponded to morphological changes within the myofibers while vimentin was negative in all the patients. There is no combined role of these proteins in the disease process. PMID:22234203

  12. Allan-Herndon syndrome. I. Clinical studies.

    PubMed Central

    Stevenson, R E; Goodman, H O; Schwartz, C E; Simensen, R J; McLean, W T; Herndon, C N

    1990-01-01

    A large family with X-linked mental retardation, originally reported in 1944 by Allan, Herndon, and Dudley, has been reinvestigated. Twenty-nine males have been affected in seven generations. Clinical features include severe mental retardation, dysarthria, ataxia, athetoid movements, muscle hypoplasia, and spastic paraplegia with hyperreflexia, clonus, and Babinski reflexes. The facies appear elongated with normal head circumference, bitemporal narrowing, and large, simple ears. Contractures develop at both small and large joint. Statural growth is normal and macroorchidism does not occur. Longevity is not impaired. High-resolution chromosomes, serum creatine kinase, and amino acids are normal. This condition, termed the Allan-Herndon syndrome, appears distinct from other X-linked disorders having mental retardation, muscle hypoplasia, and spastic paraplegia. Images Figure 2 Figure 3 PMID:2393019

  13. Oral mucocele: A clinical and histopathological study

    PubMed Central

    More, Chandramani B; Bhavsar, Khushbu; Varma, Saurabh; Tailor, Mansi

    2014-01-01

    Background: Oral mucocele is the most common benign minor (accessory) salivary gland lesion, caused due to mechanical trauma to the excretory duct of the gland. Clinically they are characterized by single or multiple, soft, fluctuant nodule, ranging from the normal color of the oral mucosa to deep blue. It affects at any age and is equally present in both sexes with highest incidence in second decade of life. They are classified as extravasation or retention type. Objectives: To analyze the data between 2010 and 2011 of, clinically and histopathologically diagnosed 58 oral mucoceles for age, gender, type, site, color, cause, symptoms and dimension. Results: Oral mucoceles were highly prevalent in the age group of 15-24 years, were seen in 51.72% of males and 48.28% of females, with a ratio of 1.07:1. The extravasation type (84.48%) was more common than the retention type (15.52%). The most common affected site was lower lip (36.20%) followed by ventral surface of the tongue (25.86%). The lowest frequency was observed in floor of mouth, upper lip and palate. The maximum numbers of mucoceles were asymptomatic (58.62%), and the color of the overlying mucosa had color of adjacent normal mucosa (48.28%). It was also observed that most of the mucoceles had diameter ranging from 5 to 14 mm. The causative factors of the lesion were lip biting (22.41%), trauma (5.18%) and numerous lesions (72.41%). Conclusion: Oral Mucoceles are frequently seen in an oral medicine service, mainly affecting young people and lower lip, measuring around 5 to 14 mm and the extravasation type being the most common. PMID:25364184

  14. Innovation in Information Technology: Theoretical and Empirical Study in SMQR Section of Export Import in Automotive Industry

    NASA Astrophysics Data System (ADS)

    Edi Nugroho Soebandrija, Khristian; Pratama, Yogi

    2014-03-01

    This paper has the objective to provide the innovation in information technology in both theoretical and empirical study. Precisely, both aspects relate to the Shortage Mispacking Quality Report (SMQR) Claims in Export and Import in Automotive Industry. This paper discusses the major aspects of Innovation, Information Technology, Performance and Competitive Advantage. Furthermore, In the empirical study of PT. Astra Honda Motor (AHM) refers to SMQR Claims, Communication Systems, Analysis and Design Systems. Briefly both aspects of the major aspects and its empirical study are discussed in the Introduction Session. Furthermore, the more detail discussion is conducted in the related aspects in other sessions of this paper, in particular in Literature Review in term classical and updated reference of current research. The increases of SMQR claim and communication problem at PT. Astra Daihatsu Motor (PT. ADM) which still using the email cause the time of claim settlement become longer and finally it causes the rejected of SMQR claim by supplier. With presence of this problem then performed to design the integrated communication system to manage the communication process of SMQR claim between PT. ADM with supplier. The systems was analyzed and designed is expected to facilitate the claim communication process so that can be run in accordance with the procedure and fulfill the target of claim settlement time and also eliminate the difficulties and problems on the previous manual communication system with the email. The design process of the system using the approach of system development life cycle method by Kendall & Kendall (2006)which design process covers the SMQR problem communication process, judgment process by the supplier, claim process, claim payment process and claim monitoring process. After getting the appropriate system designs for managing the SMQR claim, furthermore performed the system implementation and can be seen the improvement in claim communication

  15. Semi-empirical study of a set of 2-(2'-hydroxyphenyl)benzazoles using the polarizable continuum model

    NASA Astrophysics Data System (ADS)

    Iglesias, Rodrigo S.; Gonçalves, Paulo F. B.; Livotto, Paolo R.

    2000-09-01

    A set of molecules (2-(2'-hydroxyphenyl)benzoxazol (HBO), 2-(2'-hydroxyphenyl benzothiazole (HBT) and 2-(2'-hydroxyphenyl)benzimidazole (HBI)) exhibiting excited-state intramolecular proton transfer was studied using the polarizable continuum model in low-polar, non-protic solvents (chloroform and carbon tetrachloride), combined with the AM1 semi-empirical molecular orbital method in both gaseous and condensed phase. The heats of formations (Δ Hf) are lowered by the solvent effect, especially in chloroform. The increase in the solvent polarity causes an enlargement of the Stokes shift between absorption and emission.

  16. Identifying the Basis for Clinical Decisions - A Feasibility Study.

    PubMed

    Hurlen, Petter; Ofstad, Eirik; Gulbrandsen, Pål

    2016-01-01

    This study explored the possibility of defining a set of terms to describe and identify the basis for clinical decisions in a set of transcriptions from clinical encounters with previously identified decisions. The paper presents the considerations behind the exploratory study and considerations for further work. PMID:27577435

  17. An Alternative Study of Transfer of Learning in Clinical Evaluation.

    ERIC Educational Resources Information Center

    Patel, Vimla; Cranton, Patricia A.

    The use of an alternative methodology to study transfer of learning in clinical instruction during medical school was investigated. The environment in which clinical instruction takes place was examined, after which hypotheses were proposed and tested in a quasi-experimental design. The first phase of the study, an ethnographic analysis of the…

  18. Development of empirical potential functions for the study of molecular geometry, and applications to chlorophyll a dimers

    SciTech Connect

    Oie, Tetsuro

    1980-07-28

    A purpose of the present studies is twofold: (1) development of an empirical potential function (EDF) and (2) application of it to the studies of photoreaction center chlorophyll a dimer. The reliable estimate of geometric structures and energies of large molecules by quantum mechanical methods is not possible at the present time. An alternative method is, therefore, needed for the studies of large molecular systems, and Chapter I is dedicated to the development of this tool, i.e., an empirical potential function, which could suffice this purpose. Because of a large number of variable chemical compositions and functional groups characteristically present in a large molecule, it is important to include a large number of structurally diverse molecules in the development of the EPF. In Chapter II, the EPF is applied to study the geometrical structure of a chlorophyll a (Ch1 a) dimer, which is believed to exist at the photoreaction center of green plants and is known to play an essential role in photosynthetic energy conversion. Although various models have been proposed for this dimer structure, there is still a great need for information concerning the detailed geometric structure of this dimer. Therefore, in this chapter the structural stabilities of various dimer models are examined by the EPF, and detailed and quantitative information on the structure and stability of these models is provided.

  19. Development of empirical potential functions for the study of molecular geometry, and applications to chlorophyll a dimers. [Dissertation

    SciTech Connect

    Oie, Tetsuro

    1980-01-01

    A purpose of the present studies is twofold: (1) development of an empirical potential function (EPF) and (2) application of it to the studies of photoreaction center chlorophyll a dimer. The reliable estimate of geometric structures and energies of large molecules by quantum mechanical methods is not possible at the present time. An alternative method is, therefore, needed for the studies of large molecular systems, and Chapter I is dedicated to the development of this tool, i.e., an empirical potential function, which could suffice this purpose. Because of a large number of variable chemical compositions and functional groups characteristically present in a large molecule, it is important to include a large number of structurally diverse molecules in the development of the EPF. In Chapter II, the EPF is applied to study the geometrical structure of a chlorophyll a (Chl a) dimer, which is believed to exist at the photoreaction center of green plants and is known to play an essential role in photosynthetic energy conversion. Although various models have been proposed for this dimer structure, there is still a great need for information concerning the detailed geometric structure of this dimer. Therefore, in this chapter the structural stabilities of various dimer models are examined by the EPF, and detailed and quantitative information on the structure and stability of these models is provided.

  20. Reducing Adverse Polypharmacy in Patients With Borderline Personality Disorder: An Empirical Case Study

    PubMed Central

    Oldham, John M.; Gonzalez, Sylvia; Fowler, J. Christopher

    2015-01-01

    Objective: Polypharmacy is common and especially challenging in the context of borderline personality disorder in light of impulsivity and self-harm associated with the disorder, risk of adverse drug-drug interactions, and financial burden. Reduction in polypharmacy could be conceptualized as a high priority in the treatment of borderline personality disorder. This case aims to demonstrate that potential. Method: This case report presents outcomes data for an individual with borderline personality disorder during the course of an extended psychiatric hospitalization. Symptomatic change is based on the Patient Health Questionnaire Somatic, Anxiety, and Depression Symptoms scales and World Health Organization 5-Item Well-Being Index. Change in polypharmacy is presented both in terms of absolute number and complexity of the medication regimen. Clinical outcomes data are provided at 2, 12, and 24 weeks postdischarge. Results: During a 56-day hospitalization, the patient demonstrated clinical improvement across clinical domains—all occurred within the context of reduced number (43%) and complexity (40%) of her medication regimen. Symptomatic improvement was sustained up to 6 months postdischarge. Conclusions: Despite good intentions, polypharmacy can be associated with iatrogenic harm and contribute to functional impairment, especially in the context of borderline personality disorder, in which symptomatic fluctuations are part of the illness itself. A reduction in the patient’s high-risk polypharmacy during treatment represents a noteworthy treatment outcome in and of itself. Additional measures of medication risk and liability have the potential to become markers of clinical effectiveness. PMID:26693036

  1. An Examination of Qualitative Empirical Studies at the AHRD from 1999-2003: Research Purpose, Research Questions, and Inquiry Literature Cited

    ERIC Educational Resources Information Center

    Plakhotnik, Maria S.; Rocco, Tonette S.; McCarley, Howard; Ianinska, Silvana; Bernier, Judith D.

    2006-01-01

    The paper examines the nature of qualitative empirical studies published in the AHRD proceedings from 1999-2003 and discusses findings on research purpose, research question(s), and inquiry literature cited. (Contains 4 tables.)

  2. Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations.

    PubMed

    Jain, Shamini; Hammerschlag, Richard; Mills, Paul; Cohen, Lorenzo; Krieger, Richard; Vieten, Cassandra; Lutgendorf, Susan

    2015-11-01

    Biofield therapies are noninvasive therapies in which the practitioner explicitly works with a client's biofield (interacting fields of energy and information that surround living systems) to stimulate healing responses in patients. While the practice of biofield therapies has existed in Eastern and Western cultures for thousands of years, empirical research on the effectiveness of biofield therapies is still relatively nascent. In this article, we provide a summary of the state of the evidence for biofield therapies for a number of different clinical conditions. We note specific methodological issues for research in biofield therapies that need to be addressed (including practitioner-based, outcomes-based, and research design considerations), as well as provide a list of suggested next steps for biofield researchers to consider. PMID:26665043

  3. Clinical Studies of Biofield Therapies: Summary, Methodological Challenges, and Recommendations

    PubMed Central

    Hammerschlag, Richard; Mills, Paul; Cohen, Lorenzo; Krieger, Richard; Vieten, Cassandra; Lutgendorf, Susan

    2015-01-01

    Biofield therapies are noninvasive therapies in which the practitioner explicitly works with a client's biofield (interacting fields of energy and information that surround living systems) to stimulate healing responses in patients. While the practice of biofield therapies has existed in Eastern and Western cultures for thousands of years, empirical research on the effectiveness of biofield therapies is still relatively nascent. In this article, we provide a summary of the state of the evidence for biofield therapies for a number of different clinical conditions. We note specific methodological issues for research in biofield therapies that need to be addressed (including practitioner-based, outcomes-based, and research design considerations), as well as provide a list of suggested next steps for biofield researchers to consider. PMID:26665043

  4. Strategies and Challenges for Energy Efficient Retrofitting: Study of the Empire State Building

    NASA Astrophysics Data System (ADS)

    De, B.; Mukherjee, M.

    2013-11-01

    Operational and maintenance cost of existing buildings is escalating making it tough for both the owner and the tenants. Retrofitting them with state of the art technologies help them to keep pace with amended recent code provisions and thus extending the older building stocks one more chance to live responsively. Retrofitted iconic buildings can thus retain their status in commerce driven real estate sector. It helps in reducing green house gas emission as well. World's iconic skyscraper, the Empire State Building (ESB), has undergone an exemplary retrofit process since 2008 to reduce its energy demands. To achieve the goal of operational cost and energy consumption reduction, stiff challenges had taken care in a systematic manner to realize benefit throughout the entire lifespan of the ESB. Least disturbances to the tenant and on-site component handling strategies required precise planning. The present paper explores strategies and process adopted for retrofitting the ESB, and derived insightful guidelines towards operational cost savings and energy efficiency of existing buildings through retrofitting.

  5. Mind the gap: An empirical study of post-trial access in HIV biomedical prevention trials.

    PubMed

    Haire, Bridget; Jordens, Christopher

    2015-08-01

    The principle of providing post-trial access for research participants to successful products of that research is widely accepted and has been enshrined in various declarations and guidelines. While recent ethical guidelines recognise that the responsibility to provide post-trial access extends to sponsors, regulators and government bodies as well as to researchers, it is the researchers who have the direct duty of care to participants. Researchers may thus need to act as advocates for trial participants, especially where government bodies, sponsors, and regulatory bodies have complex interests vested in decisions about whether or not new interventions are made available, how, and to whom. This paper provides an empirical account of post-trial access in the context of HIV prevention research. It describes both access to the successful products of research and the provision antiretroviral drugs for trial participants who acquire HIV. First, we provide evidence that, in the current system, there is considerable variation in the duration and timeliness of access. We then argue that by analysing the difficulties faced by researchers to this point, and their efforts to meet this obligation, much can be learned about how to secure post-trial access in HIV biomedical preventions trials. While researchers alone have a limited obligation, their advocacy on behalf of trial participants may be necessary to call the other parties to account. PMID:26193849

  6. An Empirical Study of why our Cognition Toward Environmental Sustainability is Inconsistent with our Behavior: Policy Implications

    NASA Astrophysics Data System (ADS)

    Ho, S. Ping

    2016-04-01

    Raising public awareness of human environmental problems has been considered an effective way to promote public participation in environmental sustainability. From the perspective individual level, such participation mainly include the willingness of adopting less consumptive lifestyles and following the principles of reuse, reduce, and recycle. However, in reality, the development of environmental sustainability falls into the "Enlightenment Fallacy," which asserts that enlightenment does not consequentially translate into meaningful reduction of pollution. We argue that environmental awareness is mainly at the level of cognition, which is built upon knowledge and facts; whereas the behaviors toward sustainability development are largely dominated by economic principles that focus on utility maximization. As such, the Enlightenment Fallacy can be explained by the "Tragedy of Commons" which occurrs in the prevailing capitalism based economic system. This is due to the sad fact assumed in modern Economics that human beings are in general self-interested with unending desires but few moral concerns. Thus, economic individuals, who seek mainly their maximal utility or benefit, will not make significant sacrifices for improving environmental sustainability, which cannot be achieved by only a few individuals. From this perspective, we argue that only those individuals who are less self-interested and have more compassion toward mankind and earth will actively participate in environmental sustainability. In this study, we examine empirically the Enlightenment Fallacy phenomenon and develop an empirical model to test the following four hypotheses concerning the inconsistency between the environmental cognition and the actual behaviors. Policy implications for promoting public participation will be suggested based on our empirical results. Hypothesis 1: Compassion (for mankind) has larger positive impacts than environmental cognition. Hypothesis 2: Social punishment and

  7. An Empirical Study of Neural Network-Based Audience Response Technology in a Human Anatomy Course for Pharmacy Students.

    PubMed

    Fernández-Alemán, José Luis; López-González, Laura; González-Sequeros, Ofelia; Jayne, Chrisina; López-Jiménez, Juan José; Carrillo-de-Gea, Juan Manuel; Toval, Ambrosio

    2016-04-01

    This paper presents an empirical study of a formative neural network-based assessment approach by using mobile technology to provide pharmacy students with intelligent diagnostic feedback. An unsupervised learning algorithm was integrated with an audience response system called SIDRA in order to generate states that collect some commonality in responses to questions and add diagnostic feedback for guided learning. A total of 89 pharmacy students enrolled on a Human Anatomy course were taught using two different teaching methods. Forty-four students employed intelligent SIDRA (i-SIDRA), whereas 45 students received the same training but without using i-SIDRA. A statistically significant difference was found between the experimental group (i-SIDRA) and the control group (traditional learning methodology), with T (87) = 6.598, p < 0.001. In four MCQs tests, the difference between the number of correct answers in the first attempt and in the last attempt was also studied. A global effect size of 0.644 was achieved in the meta-analysis carried out. The students expressed satisfaction with the content provided by i-SIDRA and the methodology used during the process of learning anatomy (M = 4.59). The new empirical contribution presented in this paper allows instructors to perform post hoc analyses of each particular student's progress to ensure appropriate training. PMID:26815339

  8. Effects of visualizing statistical information – an empirical study on tree diagrams and 2 × 2 tables

    PubMed Central

    Binder, Karin; Krauss, Stefan; Bruckmaier, Georg

    2015-01-01

    In their research articles, scholars often use 2 × 2 tables or tree diagrams including natural frequencies in order to illustrate Bayesian reasoning situations to their peers. Interestingly, the effect of these visualizations on participants’ performance has not been tested empirically so far (apart from explicit training studies). In the present article, we report on an empirical study (3 × 2 × 2 design) in which we systematically vary visualization (no visualization vs. 2 × 2 table vs. tree diagram) and information format (probabilities vs. natural frequencies) for two contexts (medical vs. economical context; not a factor of interest). Each of N = 259 participants (students of age 16–18) had to solve two typical Bayesian reasoning tasks (“mammography problem” and “economics problem”). The hypothesis is that 2 × 2 tables and tree diagrams – especially when natural frequencies are included – can foster insight into the notoriously difficult structure of Bayesian reasoning situations. In contrast to many other visualizations (e.g., icon arrays, Euler diagrams), 2 × 2 tables and tree diagrams have the advantage that they can be constructed easily. The implications of our findings for teaching Bayesian reasoning will be discussed. PMID:26379569

  9. The administration of music therapy training clinics: a descriptive study.

    PubMed

    Abbott, Elaine A

    2006-01-01

    A two-part study was conducted to describe issues and administrative practices related to university and college affiliated music therapy training clinics. First, all 72 AMTA academic directors were surveyed in order to discover (a) which programs had a clinic, and (b) the reasons why other directors did not operate a clinic. Second, 12 survey respondents, who reported that they were involved with a training clinic, participated in in-depth interviews discussing: (a) their motivations for establishing a clinic, (b) the possible effects of a clinic on the community, (c) the individuals and groups involved in clinic operations, d) clinic space and equipment, (e) policy and procedure topics, (f) specific administrative practices related to clients and students, (g) finances, (h) research (i) quality assurance, (j) dual roles, and (k) liability issues. The administrative practices described by the interviewees varied greatly across clinics and provided a wealth of information that could be considered both useful and thought provoking for those interested in operating a music therapy clinic. PMID:16671838

  10. Congenital Rubella: Clinical and Related Studies

    ERIC Educational Resources Information Center

    Menser, Margaret A.

    1977-01-01

    Briefly described are four studies currently being undertaken in Australia to determine the effectiveness of vaccination in the prevention of rubella and to examine the relationship between rubella and diabetes. (CL)

  11. Empirical studies on informal patient payments for health care services: a systematic and critical review of research methods and instruments

    PubMed Central

    2010-01-01

    Background Empirical evidence demonstrates that informal patient payments are an important feature of many health care systems. However, the study of these payments is a challenging task because of their potentially illegal and sensitive nature. The aim of this paper is to provide a systematic review and analysis of key methodological difficulties in measuring informal patient payments. Methods The systematic review was based on the following eligibility criteria: English language publications that reported on empirical studies measuring informal patient payments. There were no limitations with regard to the year of publication. The content of the publications was analysed qualitatively and the results were organised in the form of tables. Data sources were Econlit, Econpapers, Medline, PubMed, ScienceDirect, SocINDEX. Results Informal payments for health care services are most often investigated in studies involving patients or the general public, but providers and officials are also sample units in some studies. The majority of the studies apply a single mode of data collection that involves either face-to-face interviews or group discussions. One of the main methodological difficulties reported in the publication concerns the inability of some respondents to distinguish between official and unofficial payments. Another complication is associated with the refusal of some respondents to answer questions on informal patient payments. We do not exclude the possibility that we have missed studies that reported in non-English language journals as well as very recent studies that are not yet published. Conclusions Given the recent evidence from research on survey methods, a self-administrated questionnaire during a face-to-face interview could be a suitable mode of collecting sensitive data, such as data on informal patient payments. PMID:20849658

  12. Case Study: Learner Physiotherapists' Perceptions of Clinical Education.

    ERIC Educational Resources Information Center

    Harris, Duncan; Naylor, Sandra

    1992-01-01

    Describes a study conducted in the United Kingdom to discover what processes learner physiotherapists experience in clinical education and whether their experience is comparable to that of other students in medical professions. The need for feedback is addressed, and the role of the clinical educator is discussed. A form for student assessment is…

  13. Clinical data quality problems and countermeasure for real world study.

    PubMed

    Zhang, Runshun; Wang, Yinghui; Liu, Baoyan; Song, Guangli; Zhou, Xuezhong; Fan, Shizhen; Pan, Xishui

    2014-09-01

    Real world study (RWS) has become a hotspot for clinical research. Data quality plays a vital role in research achievement and other clinical research fields. In this paper, the common quality problems in the RWS of traditional Chinese medicine are discussed, and a countermeasure is proposed. PMID:25129380

  14. An empirical study of statistical properties of variance partition coefficients for multi-level logistic regression models

    USGS Publications Warehouse

    Li, J.; Gray, B.R.; Bates, D.M.

    2008-01-01

    Partitioning the variance of a response by design levels is challenging for binomial and other discrete outcomes. Goldstein (2003) proposed four definitions for variance partitioning coefficients (VPC) under a two-level logistic regression model. In this study, we explicitly derived formulae for multi-level logistic regression model and subsequently studied the distributional properties of the calculated VPCs. Using simulations and a vegetation dataset, we demonstrated associations between different VPC definitions, the importance of methods for estimating VPCs (by comparing VPC obtained using Laplace and penalized quasilikehood methods), and bivariate dependence between VPCs calculated at different levels. Such an empirical study lends an immediate support to wider applications of VPC in scientific data analysis.

  15. [Process of perversion. Methodological and clinical study].

    PubMed

    Marchais, P

    1975-07-01

    Studies in classical psychiatry and psychoanalysis have reduced perversions to pathological phenomena, by lessening the moral criterion progressively. The applying of a comprehensive method of study of acquired perversions incites to consider various levels of observation. Henceforth properties common to each of these levels appears permitting thus to isolate a general process of perversion. This process, which keeps undeniable links with mental pathology, must however be differentiated, for it is not necessarily to be assimilated or reduced to the latter. Besides, it entails notable consequences on the social and cultural level. PMID:1233902

  16. A study of clinical and information management processes in the surgical pre-assessment clinic

    PubMed Central

    2014-01-01

    Background Establishing day-case surgery as the preferred hospital admission route for all eligible patients requires adequate preoperative assessment of patients in order to quickly distinguish those who will require minimum assessment and are suitable for day-case admission from those who will require more extensive management and will need to be admitted as inpatients. Methods As part of a study to elucidate clinical and information management processes within the patient surgical pathway in NHS Scotland, we conducted a total of 10 in-depth semi-structured interviews during 4 visits to the Dumfries & Galloway Royal Infirmary surgical pre-assessment clinic. We modelled clinical processes using process-mapping techniques and analysed interview data using qualitative methods. We used Normalisation Process Theory as a conceptual framework to interpret the factors which were identified as facilitating or hindering information elucidation tasks and communication within the multi-disciplinary team. Results The pre-assessment clinic of Dumfries & Galloway Royal Infirmary was opened in 2008 in response to clinical and workflow issues which had been identified with former patient management practices in the surgical pathway. The preoperative clinic now operates under well established processes and protocols. The use of a computerised system for managing preoperative documentation substantially transformed clinical practices and facilitates communication and information-sharing among the multi-disciplinary team. Conclusion Successful deployment and normalisation of innovative clinical and information management processes was possible because both local and national strategic priorities were synergistic and the system was developed collaboratively by the POA staff and the health-board IT team, resulting in a highly contextualised operationalisation of clinical and information management processes. Further concerted efforts from a range of stakeholders are required to fully

  17. Empirical tests of the Chicago model and the Easterlin hypothesis: a case study of Japan.

    PubMed

    Ohbuchi, H

    1982-05-01

    The objective of this discussion is to test the applicability of economic theory of fertility with special reference to postwar Japan and to find a clue for forecasting the future trend of fertility. The theories examined are the "Chicago model" and the "Easterlin hypothesis." The major conclusion common among the leading economic theories of fertility, which have their origin with Gary S. Becker (1960, 1965) and Richard A. Easterlin (1966), is the positive income effect, i.e., that the relationship between income and fertility is positive despite the evidence that higher income families have fewer children and that fertility has declined with economic development. To bridge the gap between theory and fact is the primary purpose of the economic theory of fertility, and each offers a different interpretation for it. The point of the Chicago model, particularly of the household decision making model of the "new home economics," is the mechanism that a positive effect of husband's income growth on fertility is offset by a negative price effect caused by the opportunity cost of wife's time. While the opportunity cost of wife's time is independent of the female wage rate for an unemployed wife, it is directly associated with the wage rate for a gainfully employed wife. Thus, the fertility response to female wages occurs only among families with an employed wife. The primary concern of empirical efforts to test the Chicago model has been with the determination of income and price elasticities. An attempt is made to test the relevance of the Chicago model and the Easterlin hypothesis in explaning the fertility movement in postwar Japan. In case of the Chicago model, the statistical results appeared fairly successful but did not match with the theory. The effect on fertility of a rise in women's real wage (and, therefore in the opportunity cost of mother's time) and of a rise in labor force participation rate of married women of childbearing age in recent years could not

  18. Current trends in the empirical study of cognitive remediation for schizophrenia.

    PubMed

    Saperstein, Alice M; Kurtz, Matthew M

    2013-06-01

    Cognitive remediation (CR) for schizophrenia is a learning-based behavioural skills training intervention designed to enhance neuro and (or) social cognitive skills, with the ultimate goal of generalization to improve psychosocial outcomes. This review summarizes conceptual approaches to CR for schizophrenia and the evidence for efficacy in clinical research settings. Four issues are at the forefront of ongoing research: the identification of techniques that produce the largest cognitive change, delineation of techniques that enhance transfer of cognitive skills to functional skills, the identification of CR methods that can be personalized to meet the specific cognitive and functional needs of each individual, and, all the while, ensuring that when CR methods are developed in a research setting, they remain scalable for delivery in the larger clinical community. In response to these issues, 3 prominent research trends have emerged: the rise of a new generation of computerized restorative cognitive training, the integration of CR with skills training to promote generalization, and the application of techniques to enhance motivation and learning during CR. As data on the neural basis of learning in people with schizophrenia become available, new technologies that harness the ability of the brain to make sustainable, functional changes may be integrated within a therapeutic context that promotes a personalized approach to learning. The development of transportable and scalable methods of CR that maximize the ability of people with schizophrenia to improve cognition will help them achieve personal goals for recovery. PMID:23768258

  19. Dyslexia: advances in clinical and imaging studies.

    PubMed

    Koeda, Tatsuya; Seki, Ayumi; Uchiyama, Hitoshi; Sadato, Norihiro

    2011-03-01

    The aim of this report is to describe the characteristics of Japanese dyslexia, and to demonstrate several of our studies about the extraction of these characteristic and their neurophysiological and neuroimaging abnormalities, as well as advanced studies of phonological awareness and the underlying neural substrate. Based on these results, we have proposed a 2-step approach for remedial education (e-learning web site: http://www.dyslexia-koeda.jp/). The first step is decoding, which decreases reading errors, and the second is vocabulary learning, which improves reading fluency. This 2-step approach is designed to serve first grade children. In addition, we propose the RTI (response to intervention) model as a desirable system for remedial education. PMID:21146943

  20. A clinical pathologic study of mercurialentis medicamentosus.

    PubMed Central

    Garron, L K; Wood, I S; Spencer, W H; Hayes, T L

    1976-01-01

    Thirty-one patients who used eye drops containing the preservative, phenylmercuric nitrate for from 3 to 15 years, developed a brownish pigmentation of the anterior capsule of the pupillary area. Light and electron microscopic studies on two lenses demonstrated deposits of dense particulate material resembling melanin pigment on and in the anterior capsule of the lens in the area of the pupil. Special studies, including electron microprobe analysis and neutron activation analysis established the presence of mercury in a lens with mercurialentis. No mercury was found in two lenses used as controls. Images FIGURE 1 FIGURE 2 A FIGURE 2 B FIGURE 3 FIGURE 4 A FIGURE 4 B FIGURE 5 FIGURE 6 FIGURE 7 FIGURE 8 FIGURE 9 A FIGURE 9 B FIGURE 9 C PMID:867632

  1. Review of clinical studies on clobazam

    PubMed Central

    Koeppen, D.

    1979-01-01

    1 Clobazam was compared with placebo and diazepam in 45 double-blind studies. 2 Clobazam dosage ranged from 5 mg daily (paediatric patients) to 120 mg daily (psychiatric inpatients). Usual daily dosage in out-patient therapy ranged from 20-30 mg clobazam. 3 Treatment duraton varied from a few days up to 3.5 years. The usual duration of treatment was 2-4 weeks. 4 Clobazam was shown to be an efficacious and well tolerated anxiolytic agent in various neurotic and psychosomatic disorders. 5 Dosages showing distinct anxiolytic effects in out-patient therapy did not impair psychomotor performance. PMID:35197

  2. Driving factors of carbon dioxide emissions in China: an empirical study using 2006-2010 provincial data

    NASA Astrophysics Data System (ADS)

    Liu, Yu; Chen, Zhan-Ming; Xiao, Hongwei; Yang, Wei; Liu, Danhe; Chen, Bin

    2016-04-01

    The rapid urbanization of China has increased pressure on its environmental and ecological well being. In this study, the temporal and spatial profiles of China's carbon dioxide emissions are analyzed by taking heterogeneities into account based on an integration of the extended stochastic impacts using a geographically and temporally weighted regression model on population, affluence, and technology. Population size, urbanization rate, GDP per capita, energy intensity, industrial structure, energy consumption pattern, energy prices, and economy openness are identified as the key driving factors of regional carbon dioxide emissions and examined through the empirical data for 30 provinces during 2006-2010. The results show the driving factors and their spillover effects have distinct spatial and temporal heterogeneities. Most of the estimated time and space coefficients are consistent with expectation. According to the results of this study, the heterogeneous spatial and temporal effects should be taken into account when designing policies to achieve the goals of carbon dioxide emissions reduction in different regions.

  3. Hypoxemia in pulmonary embolism, a clinical study

    PubMed Central

    Wilson, James E.; Pierce, Alan K.; Johnson, Robert L.; Winga, Edward R.; Harrell, W. Ross; Curry, George C.; Mullins, Charles B.

    1971-01-01

    The cause of hypoxemia was studied in 21 patients with no previous heart or lung disease shortly after an episode of acute pulmonary embolism. The diagnosis was based on pulmonary angiography demonstrating distinct vascular filling defects or “cutoffs.” It was found that virtually all of the hypoxemia in patients with previously normal heart and lungs could be accounted for on the basis of shunt-like effect. The magnitude of the shunting did not correlate with the percent of the pulmonary vascular bed occluded nor with the mean pulmonary artery pressure. The shunts tended to gradually recede over about a month after embolism. Patients without pulmonary infarction were able to inspire 80-111% of their predicted inspiratory capacities, and this maneuver temporarily diminished the observed shunt. Patients with pulmonary infarcts were able to inhale only to 60-69% of predicted inspiratory capacity, and this did not reverse shunting. These data suggest that the cause of right-to-left shunting in patients with pulmonary emboli is predominantly atelectasis. When the elevation of mean pulmonary artery pressure was compared to cardiac index per unit of unoccluded lung, it fell within the range of pulmonary hypertension predicted from published data obtained in patients with exercise in all except one case. This observation suggests that pulmonary vasoconstriction following embolism is not important in humans, although these data are applicable only during the time interval in which our patients were studied and in patients receiving heparin. PMID:5101776

  4. Clinical cosmobiology: The Lithuanian study 1990 1992

    NASA Astrophysics Data System (ADS)

    Stoupel, Eliyahu; Petrauskiene, Jadviga; Kalediene, Ramune; Abramson, Evgeny; Sulkes, Jacqueline

    1995-12-01

    The numbers of deaths from ischaemic heart disease (IHD), stroke (CVA), all accidents except vehicular, vehicular accidents and suicide (overall total, totals for men and women) per month for 36 months (1990 1992) in Lithuania were analysed in relation to: (1) month of the year (1 12); (2) geomagnetic activity; and (3) solar activity. A total of 122227 deaths (64490 men and 57737 women) was studied, and the results compared with those obtained in an earlier study in Israel, differing geographically and climatically from Lithuania. It was shown that the time of year, solar activity, and geomagnetic activity were related to the monthly death distribution, especially regarding death from IHD and suicide. Age and gender differences were apparent in the relationship between death distribution and physical environmental factors. At age >70 years, many of these relationships change. The monthly distribution of deaths from IHD and suicide are adversely correlated with solar activity and with each other. Differences are presumed in serotoninergic effects as caused by environmental influences.

  5. Empire: An Analytical Category for Educational Research

    ERIC Educational Resources Information Center

    Coloma, Roland Sintos

    2013-01-01

    In this article Roland Sintos Coloma argues for the relevance of empire as an analytical category in educational research. He points out the silence in mainstream studies of education on the subject of empire, the various interpretive approaches to deploying empire as an analytic, and the importance of indigeneity in research on empire and…

  6. Facilitating case studies in massage therapy clinical education.

    PubMed

    Baskwill, Amanda

    2013-01-01

    The integration of evidence into reflective health care practice has been on the rise in recent years and is a phenomenon that has affected all health care professions, including massage therapy. Clinical case studies are a research design that follows one patient or subject, making the studies ideal for use in clinical practice. They are valuable for communicating information from clinical practice to the broader community. Case studies have face validity that may be more valuable to individual practitioners than homogeneous randomized controlled trials, as the practitioner may recognize a complex patient in the case report. At Humber College, Student Massage Therapists (SMTs) create, conduct, and communicate results of a clinical case study prior to graduation. This article describes the process and experience. PMID:23730397

  7. Dementia in Ageing Mental Defectives: A Clinical and Neuropathological Study.

    ERIC Educational Resources Information Center

    Reid, A. H.; And Others

    1978-01-01

    The study was aimed at establishing the prevalence and clinical features of the psychoses of senescence (senile, presenile, and cerebral arteriosclerotic dementias) in 155 mentally retarded patients over the age of 45. (SBH)

  8. How to evaluate study methodology in published clinical research.

    PubMed

    Stoddard, G J; Ring, W H

    1993-01-01

    When reading a clinical research article, the clinician must judge if the reported findings and conclusions are valid before applying them to patient care. This concern is legitimate given the wide range of study validity in the clinical literature. In this article, the authors present many validity markers that signify the quality of the information reported from a study, such as authorship, bias, confounding, statistics, randomization, controls, blinding, and the logical framework of scientific investigations. PMID:8478779

  9. Oral hybrid verrucous carcinoma: a clinical study.

    PubMed

    Gokavarapu, Sandhya; Rao S, L M Chandrasekhara; Tantravahi, Uma Sankar; Gundimeda, Sandhya Devi; Rao, T Subramaneshwar; Murthy, Sudha

    2014-12-01

    Hybrid Verrucous Carcinoma is an uncommon tumour wherein Verrucous Carcinoma (VC) is coexisting with conventional Squamous Cell Carcinoma (SCC) within same maternal field. The heterogeneous nature, infrequency of occurrence and the difficulties associated with diagnosis and management of this tumor is discussed through a retrospective study. Patients of primary hybrid VC treated from Jan 2010 to May 2013 at a tertiary institute were analyzed on multivariate cox regression model. During the above mentioned period; 37 patients of hybrid VC were reported; 18(48.6 %) were male and 19(51.3 %) were female. Age ranged between 33 years to 78 years. Median follow up period was 32 months. T stage status and Stage grouping was not statistically significant for mortality (p value: 0.338). In the multivariate cox-regression model, the presence of second primary oral cancer was significantly associated with mortality, adjusted HR; 23.10 (95 % CI: 1.73, 307.65) (p = 0.017). Tumour staging is often unreliable in predicting prognosis of hybrid VC, occurrence of second primary oral cancer and recurrence appears to be significant factors effecting prognosis. PMID:25767335

  10. [Clinical study of occupational uroepithelial cancer].

    PubMed

    Hamasaki, T; Aramaki, K; Hida, T; Inatomi, H; Fujimoto, N; Okamura, T; Ozu, K; Sugita, A

    1996-12-01

    We studied 438 persons who were engaged in the production and use of aromatic amines (benzidine sulfate, beta-naphthylamine, alpha-naphthylamine and dianisidine). Among these 438 persons, 88 new cases of occupational uroepithelial cancer had occurred from 1949 to 1995. The incident rate of occupational uroepithelial cancer was 20.1%. The average exposure period of these 88 cases to the aromatic amines was 7.40 years (range, 0.75-26.75), and the incidence rate of tumors increased with the length of exposure to aromatic amines. The average latent period was 26.79 years (range, 1.33-48.50), and the average age of first onset was 52.59 (range, 24-79). Recently it has been determined that the longer the latent period, the older the age of first onset. Of these 88 cases, the tumor sites were bladder in 67 cases (76.1%) and upper urinary tract (renal pelvis and/or ureter) in 5 cases (5.7%). The other 16 cases (18.2%) were the bladder and upper urinary tract. The screening examination for chemical workers using urinary cytology was begun in 1962. In our cases, urine cytology was a useful method for diagnosing occupational uroepithelial cancer. As for initial treatment of the 88 cases, transurethral surgery was most frequently performed, that is on 58 cases (65.9%). However, eight cases (9.1%) had to undergo a total nephroureterectomy, and six cases (6.8%) had a total cystectomy. Recurrence was observed in 61 cases (69.3%) out of the 88 patients with an average of 1.81 times. The other organic cancers developed in 39 cases (8.9%) out of 438 workers who were exposed to aromatic amines and in 8 cases out of 88 patients (9.1%). Prognosis of the 88 patients is that, the number of alive and dead is 51 (58.0%) and 37 (42.0%) respectively on December 31, 1995. Twenty-eight patients (31.8%) died of uroepithelial cancer, and five patients (5.7%) died of other organic cancers. The survival rates of 5, 10, 15 and 20 years was 87.9%, 74.0%, 65.9% and 56.3%, respectively. From these

  11. Learner Autonomy in the English Classroom: Empirical Studies and Ideas for Teachers

    ERIC Educational Resources Information Center

    Lennon, Paul, Ed.

    2012-01-01

    The volume consists of twelve classroom studies concerned with the implementation of learner autonomy in English classes. The individual studies range from primary school level to university level. They include studies on multi-media dictionary work, reading logs, peer correction, communication strategies, vocabulary learning strategies, oral…

  12. Do Learning and Study Skills Affect Academic Performance?--An Empirical Investigation

    ERIC Educational Resources Information Center

    Griffin, Richard; MacKewn, Angie; Moser, Ernest; VanVuren, Ken W.

    2012-01-01

    Universities and colleges are very interested in understanding the factors that influence their students' academic performance. This paper describes a study that was conducted at a mid-sized public university in the mid-south, USA, to examine this issue. In this study, the 10-scale, Learning and Study Strategies Inventory (LASSI) (Weinstein et…

  13. Enhancing Patient Safety Using Clinical Nursing Data: A Pilot Study.

    PubMed

    Choi, Jeeyae; Choi, Jeungok E

    2016-01-01

    To enhance patient safety from falls, many hospital information systems have been implemented to collect clinical data from the bedside and have used the information to improve fall prevention care. However, most of them use administrative data not clinical nursing data. This necessitated the development of a web-based Nursing Practice and Research Information Management System (NPRIMS) that processes clinical nursing data to measure nurses' delivery of fall prevention care and its impact on patient outcomes. This pilot study developed computer algorithms based on a falls prevention protocol and programmed the prototype NPRIMS. It successfully measured the performance of nursing care delivered and its impact on patient outcomes using clinical nursing data from the study site. Results of the study revealed that NPRIMS has the potential to pinpoint components of nursing processes that are in need of improvement for preventing patient from falls. PMID:27332171

  14. Practicing nurses perspectives of clinical scholarship: a qualitative study

    PubMed Central

    2013-01-01

    Background There is a scarcity of research published on clinical scholarship. Much of the conceptualisation has been conducted in the academy. Nurse academics espouse that the practice of nursing must be built within a framework of clinical scholarship. A key concept of clinical scholarship emerging from discussions in the literature is that it is an essential component of enabling evidence–based nursing and the development of best practice standards to provide for the needs of patients/clients. However, there is no comprehensive definition of clinical scholarship from the practicing nurses. The aim of this study was to contribute to this definitional discussion on the nature of clinical scholarship in nursing. Methods Naturalistic inquiry informed the method. Using an interpretative approach 18 practicing nurses from Australia, Canada and England were interviewed using a semi-structured format. The audio-taped interviews were transcribed and the text coded for emerging themes. The themes were sorted into categories and the components of clinical scholarship described by the participants compared to the scholarship framework of Boyer [JHEOE 7:5-18, 2010]. Results Clinical scholarship is difficult to conceptualise. Two of the essential elements of clinical scholarship are vision and passion. The other components of clinical scholarship were building and disseminating nursing knowledge, sharing knowledge, linking academic research to practice and doing practice-based research. Conclusion Academic scholarship dominated the discourse in nursing. However, in order for nursing to develop and to impact on health care, clinical scholarship needs to be explored and theorised. Nurse educators, hospital-based researchers and health organisations need to work together with academics to achieve this goal. Frameworks of scholarship conceptualised by nurse academics are reflected in the findings of this study with their emphasis on reading and doing research and translating it

  15. A Systematic Review of Studies Comparing Diagnostic Clinical Prediction Rules with Clinical Judgment

    PubMed Central

    Sanders, Sharon; Doust, Jenny; Glasziou, Paul

    2015-01-01

    Background Diagnostic clinical prediction rules (CPRs) are developed to improve diagnosis or decrease diagnostic testing. Whether, and in what situations diagnostic CPRs improve upon clinical judgment is unclear. Methods and Findings We searched MEDLINE, Embase and CINAHL, with supplementary citation and reference checking for studies comparing CPRs and clinical judgment against a current objective reference standard. We report 1) the proportion of study participants classified as not having disease who hence may avoid further testing and or treatment and 2) the proportion, among those classified as not having disease, who do (missed diagnoses) by both approaches. 31 studies of 13 medical conditions were included, with 46 comparisons between CPRs and clinical judgment. In 2 comparisons (4%), CPRs reduced the proportion of missed diagnoses, but this was offset by classifying a larger proportion of study participants as having disease (more false positives). In 36 comparisons (78%) the proportion of diagnoses missed by CPRs and clinical judgment was similar, and in 9 of these, the CPRs classified a larger proportion of participants as not having disease (fewer false positives). In 8 comparisons (17%) the proportion of diagnoses missed by the CPRs was greater. This was offset by classifying a smaller proportion of participants as having the disease (fewer false positives) in 2 comparisons. There were no comparisons where the CPR missed a smaller proportion of diagnoses than clinical judgment and classified more participants as not having the disease. The design of the included studies allows evaluation of CPRs when their results are applied independently of clinical judgment. The performance of CPRs, when implemented by clinicians as a support to their judgment may be different. Conclusions In the limited studies to date, CPRs are rarely superior to clinical judgment and there is generally a trade-off between the proportion classified as not having disease and the

  16. An empirical study of the effectiveness of electronic stability control system in reducing loss of vehicle control.

    PubMed

    Papelis, Yiannis E; Watson, Ginger S; Brown, Timothy L

    2010-05-01

    A significant percentage of fatal vehicle crashes involve loss of control (LOC). Electronic stability control (ESC) is an active safety system that detects impending LOC and activates counter-measures that help the driver maintain or re-gain control. To assess the effectiveness of ESC in preventing LOC, an empirical study was conducted on a high-fidelity driving simulator. The ESC systems for two vehicles were incorporated into the simulator's dynamics code which was calibrated to ensure engineering validation. The study utilized three scenarios designed to recreate typical LOC situations, and was designed to assess the effects of ESC presence, vehicle type, scenario, age and gender. A total of 120 research participants completed the study. Results showed a statistically significant reduction in LOC with ESC compared to without ESC (F=52.72, p<0.0001). The study findings of 5% LOC with ESC and 30% without ESC match several epidemiological studies that have analyzed ESC effectiveness on real-world crashes, providing strong support to the use of driving simulation for studying driver behavior. Study conclusions suggest that wide-spread utilization of ESC is likely to reduce traffic fatalities. PMID:20380922

  17. Developing Empirical Benchmarks of Teacher Knowledge Effect Sizes in Studies of Professional Development Effectiveness

    ERIC Educational Resources Information Center

    Phelps, Geoffrey; Jones, Nathan; Kelcey, Ben; Liu, Shuangshuang; Kisa, Zahid

    2013-01-01

    Growing interest in teaching quality and accountability has focused attention on the need for rigorous studies and evaluations of professional development (PD) programs. However, the study of PD has been hampered by a lack of suitable instruments. The authors present data from the Teacher Knowledge Assessment System (TKAS), which was designed to…

  18. Promoting a Culture of Parent Collaboration and Trust: An Empirical Study

    ERIC Educational Resources Information Center

    Adams, Curt M.; Forsyth, Patrick B.

    2007-01-01

    This study investigated the effects of formalized and centralized school structures on 2 emergent concepts in the study of school reform, trust, and collaboration. Trust and collaboration were examined from the perspective of parents, as opposed to internal school agents such as teachers or students. Three hierarchical multiple regressions…

  19. Design Principles of Worked Examples: A Review of the Empirical Studies

    ERIC Educational Resources Information Center

    Shen, Chun-Yi; Tsai, Hui-Chun

    2009-01-01

    Many researchers investigated the efficacy of using worked examples in classroom instruction and provided evidence in the effectiveness of worked example instruction in mathematics, computer programming, physics, and etc. However, there are limited studies in worked example design. The purpose of this study is to generate the instructional design…

  20. The Role of Individual Differences in Internet Searching: An Empirical Study.

    ERIC Educational Resources Information Center

    Ford, Nigel; Miller, David; Moss, Nicola

    2001-01-01

    This article reports the results of a study of Master's degree students concerning the role of individual differences in Internet searching, including cognitive styles, levels of prior experience, Internet perceptions, study approaches, age, and gender. Discusses retrieval effectiveness and self-efficacy and suggests implications for system…

  1. Mobile Phone Use in a Developing Country: A Malaysian Empirical Study

    ERIC Educational Resources Information Center

    Yeow, Paul H. P.; Yen Yuen, Yee; Connolly, Regina

    2008-01-01

    This study examined the factors that influence consumer satisfaction with mobile telephone use in Malaysia. The validity of the study's constructs, criterion, and content was confirmed. Construct validity was verified through the factor analysis with a total variance of 73.72 percent explained by all six independent factors. Content validity was…

  2. The IEA Six Subject Survey: An Empirical Study of Education in Twenty-One Countries.

    ERIC Educational Resources Information Center

    Walker, David A.

    The purpose of this book is to describe in nontechnical language the objectives, methods and findings of the six subject study conducted by the International Association for the Evaluation of Educational Achievement during the years 1966-1973. The six subjects covered in the study were Science, Reading Comprehension, Literature, English as a…

  3. Get Your Degree from an Educational ATM: An Empirical Study in Online Education

    ERIC Educational Resources Information Center

    Lee, Y.; Nguyen, H.

    2007-01-01

    This article studies the modern trend of online education in the United States. Based on a wide range of statistics, the number of cyberspace courses offered by four-year institutions and universities nationwide has rapidly increased over the past one and a half decades. Under a case study, colleges of business from ranked universities and…

  4. Is Pedagogical Content Knowledge (PCK) Necessary for Reformed Science Teaching?: Evidence from an Empirical Study

    ERIC Educational Resources Information Center

    Park, Soonhye; Jang, Jeong-Yoon; Chen, Ying-Chih; Jung, Jinhong

    2011-01-01

    This study tested a hypothesis that focused on whether or not teachers' pedagogical content knowledge (PCK) is a necessary body of knowledge for reformed science teaching. This study utilized a quantitative research method to investigate the correlation between a teacher's PCK level as measured by the PCK rubric (Park et al. 2008) and the degree…

  5. A Factor Analysis on Teamwork Performance: An Empirical Study of Inter-Instituted Collaboration

    ERIC Educational Resources Information Center

    Wu, Mingchang; Chen, Ya-Hsueh

    2014-01-01

    Problem Statement: Inter-instituted collaboration has attracted broad attention for educational quality improvement in the last decade. The team performance of these innovative team projects received foremost attention, particularly with knowledge-sharing, emotional intelligence, and team conflicts. Purpose of Study: The purpose of the study was…

  6. The Role of Readiness Factors in E-Learning Outcomes: An Empirical Study

    ERIC Educational Resources Information Center

    Keramati, Abbas; Afshari-Mofrad, Masoud; Kamrani, Ali

    2011-01-01

    Although many researchers have studied different factors which affect E-Learning outcomes, there is little research on assessment of the intervening role of readiness factors in E-Learning outcomes. This study proposes a conceptual model to determine the role of readiness factors in the relationship between E-Learning factors and E-Learning…

  7. An Empirical Study on the Determinants of International Student Mobility: A Global Perspective

    ERIC Educational Resources Information Center

    Wei, Hao

    2013-01-01

    This paper, based on the data of 48 countries and regions from 1999 to 2008, studies the economic and educational determinants of how countries of different types attract international students. The study finds that: the volume of merchandise trade between countries facilitates international student mobility across borders; international students…

  8. The Impact of Sexual Abuse on Children: A Review and Synthesis of Recent Empirical Studies.

    ERIC Educational Resources Information Center

    Kendall-Tackett, Kathleen A.; And Others

    Until recently the literature on the impact of child sexual abuse has consisted disproportionately of retrospective studies of adults. Research on children allows for a developmental perspective and includes the first efforts at longitudinal studies of sexual abuse victims. This literature also has important relevance to other theory and research…

  9. Self-Efficacy, Mathematics' Anxiety and Perceived Importance: An Empirical Study with Portuguese Engineering Students

    ERIC Educational Resources Information Center

    Alves, Manuela; Rodrigues, Cristina S.; Rocha, Ana Maria A. C.; Coutinho, Clara

    2016-01-01

    The accomplishment in mathematics has gained attention from educators and arises as an emerging field of study, including in engineering education. However, in Portugal, there is still incipient research in the area; so it is high time to explore factors that might enlighten the gap in the study of the relationship between Portuguese engineering…

  10. An Empirical Study of Earth Covered Schools in Oklahoma. Final Report.

    ERIC Educational Resources Information Center

    Zaccor, James V.

    A study of earth-covered schools in Oklahoma was conducted for the Federal Emergency Management Agency (FEMA) to assess the viability of these structures as learning and teaching environments, as cost beneficial investments, and as potential shelters from natural and man-made disasters. The study was aimed at identifying what information is…

  11. Psychological Determinants of University Students' Academic Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Gebka, Bartosz

    2014-01-01

    This study utilises an integrated conceptual model of academic performance which captures a series of psychological factors: cognitive style; self-theories such as self-esteem and self-efficacy; achievement goals such as mastery, performance, performance avoidance and work avoidance; study-processing strategies such as deep and surface learning;…

  12. An Empirical Study of Kirkpatrick's Evaluation Model in the Hospitality Industry

    ERIC Educational Resources Information Center

    Chang, Ya-Hui Elegance

    2010-01-01

    This study examined Kirkpatrick's training evaluation model (Kirkpatrick & Kirkpatrick, 2006) by assessing a sales training program conducted at an organization in the hospitality industry. The study assessed the employees' training outcomes of knowledge and skills, job performance, and the impact of the training upon the organization. By…

  13. Cases for the Net Generation: An Empirical Examination of Students' Attitude toward Multimedia Case Studies

    ERIC Educational Resources Information Center

    Sheppard, Michael; Vibert, Conor

    2016-01-01

    Case studies have been an important tool in business, legal, and medical education for generations of students. Traditional text-based cases tend to be self-contained and structured in such a way as to teach a particular concept. The multimedia cases introduced in this study feature unscripted web-hosted video interviews with business owners and…

  14. Revising Basic Mathematics in a Network Environment: An Empirical Study with Finnish Technology University Students

    ERIC Educational Resources Information Center

    Ketamo, Harri; Alajaaski, Jarkko

    2008-01-01

    A revising/replenishment study course in basic mathematics is experienced as being almost a necessity at the beginning of technology studies at the Tampere University of Technology, Pori, Finland. This is to avoid early dropouts in actual engineering mathematics courses. Experimental research on factors explaining successful revision of…

  15. Evaluating the Impact of an Environmental Education Programme: An Empirical Study in Mexico

    ERIC Educational Resources Information Center

    Ruiz-Mallen, Isabel; Barraza, Laura; Bodenhorn, Barbara; Reyes-Garcia, Victoria

    2009-01-01

    This study draws on information from 11 in-depth interviews, two focus groups and 72 written questionnaires to evaluate an extra-curricular environmental education programme on forestry designed for preparatory school students from a small rural community in Mexico. Specifically, the study assessed the impact of the programme on the ecological…

  16. Amalgamation of Future Time Orientation, Epistemological Beliefs, Achievement Goals and Study Strategies: Empirical Evidence Established

    ERIC Educational Resources Information Center

    Phan, Huy P.

    2009-01-01

    Background: Recently research evidence emphasizes two main lines of inquiry, namely the relations between future time perspective (FTP), achievement goals (mastery, performance-approach, and performance-avoidance) and study processing strategies, and the relations between epistemological beliefs, achievement goals and study processing strategies.…

  17. Social Exclusion and Quality of Life: An Empirical Study from Turkey

    ERIC Educational Resources Information Center

    Bayram, Nuran; Bilgel, Firat; Bilgel, Nazan Gonul

    2012-01-01

    We examine the perception of social exclusion and quality of life and their interactions among a group of Turkish citizens. For this purpose we used the social exclusion scale developed by Jehoel-Gijsbers and Vrooman and the WHOQOL-BREF scale. The study group consists of 2,493 participants who are residents of a city in Turkey. Our study was based…

  18. Birds on a wire: empirical studies of flocking dyna-mics in linear aggregates

    NASA Astrophysics Data System (ADS)

    Schwartz, Elliott; Fulton, Andrew; Rosenthal, Lee; Kane, Suzanne Amador

    2014-03-01

    The dynamics of avian flocking is difficult to study because of the transient, highly mobile and unpredictable nature of bird flocks. However, birds often form clusters when perched on wires and fences, offering a stable platform for studying the formation, internal structure and dynamics of these approximately one-dimensional flocks. Previous studies have examined the distribution of the distances between birds perched on wires, but not the time-dependence of this behavior. We present results from a video study of cliff swallows (Petrochelidon pyrrhonota) perched on power lines in Sierra Valley, California. Phenomena studied include how the interbird distance distribution varies as a function of time, what factors influence the addition of further birds to an existing cluster, how the distribution evolves in response to perturbations, and typical timescales for the observed behaviors.

  19. Nursing Students' Clinical Experience With Death: A Pilot Study.

    PubMed

    Heise, Barbara A; Gilpin, Laura C

    2016-01-01

    Although debriefing in simulation settings is routine in nursing education, debriefing does not routinely take place in clinical settings with nursing students after a patient has died. This pilot study sought to explore nursing students' perceptions of their first experience with the death of a patient. Students reported emotional distress and feelings of inadequacy with regard to communicating with and supporting the family of the dying patient. Only half the students sampled reported debriefing by their clinical instructor or staff. Nurse educators must include debriefing and student support following a patient death in the clinical setting. PMID:27209870

  20. The Auckland skin clinic tinea pedis and erythrasma study.

    PubMed

    Allen, S; Christmas, T I; McKinney, W; Parr, D; Oliver, G F

    1990-08-22

    Three hundred consecutive patients attending the Auckland Hospital dermatology clinic were examined clinically and microbiologically for evidence of interdigital or plantar mycological or bacterial infection. One hundred and nine patients were shown by laboratory investigation to have an infection. Of these, only 89 displayed clinical signs of infection. Erythrasma, a desquamative condition caused by Corynebacterium minutissimum, was the commonest infection in this study. The commonest dermatophyte isolated was Trichophyton mentagrophytes var interdigitale. There was a significant rise in the incidence of both types of infection with age. PMID:2385417

  1. Can electronic search engines optimize screening of search results in systematic reviews: an empirical study

    PubMed Central

    Sampson, Margaret; Barrowman, Nicholas J; Moher, David; Clifford, Tammy J; Platt, Robert W; Morrison, Andra; Klassen, Terry P; Zhang, Li

    2006-01-01

    Background Most electronic search efforts directed at identifying primary studies for inclusion in systematic reviews rely on the optimal Boolean search features of search interfaces such as DIALOG® and Ovid™. Our objective is to test the ability of an Ultraseek® search engine to rank MEDLINE® records of the included studies of Cochrane reviews within the top half of all the records retrieved by the Boolean MEDLINE search used by the reviewers. Methods Collections were created using the MEDLINE bibliographic records of included and excluded studies listed in the review and all records retrieved by the MEDLINE search. Records were converted to individual HTML files. Collections of records were indexed and searched through a statistical search engine, Ultraseek, using review-specific search terms. Our data sources, systematic reviews published in the Cochrane library, were included if they reported using at least one phase of the Cochrane Highly Sensitive Search Strategy (HSSS), provided citations for both included and excluded studies and conducted a meta-analysis using a binary outcome measure. Reviews were selected if they yielded between 1000–6000 records when the MEDLINE search strategy was replicated. Results Nine Cochrane reviews were included. Included studies within the Cochrane reviews were found within the first 500 retrieved studies more often than would be expected by chance. Across all reviews, recall of included studies into the top 500 was 0.70. There was no statistically significant difference in ranking when comparing included studies with just the subset of excluded studies listed as excluded in the published review. Conclusion The relevance ranking provided by the search engine was better than expected by chance and shows promise for the preliminary evaluation of large results from Boolean searches. A statistical search engine does not appear to be able to make fine discriminations concerning the relevance of bibliographic records that have

  2. Nurses' attitudes to euthanasia: the influence of empirical studies and methodological concerns on nursing practice.

    PubMed

    Holt, Janet

    2008-10-01

    This paper introduces the controversy surrounding active voluntary euthanasia and describes the legal position on euthanasia and assisted suicide in the UK. Findings from studies of the nurses' attitudes to euthanasia from the national and international literature are reviewed. There are acknowledged difficulties in carrying out research into attitudes to euthanasia and hence the review of findings from the published studies is followed by a methodological review. This methodological review examines the research design and data collection methods used in the published studies, problems with understanding definitions of euthanasia and the measurement of attitudes. The paper concludes with a discussion of how research in this area may influence nursing practice. PMID:18798897

  3. Empirical study of self-configuring genetic programming algorithm performance and behaviour

    NASA Astrophysics Data System (ADS)

    Semenkin, E.; Semenkina, M.

    2015-01-01

    The behaviour of the self-configuring genetic programming algorithm with a modified uniform crossover operator that implements a selective pressure on the recombination stage, is studied over symbolic programming problems. The operator's probabilistic rates interplay is studied and the role of operator variants on algorithm performance is investigated. Algorithm modifications based on the results of investigations are suggested. The performance improvement of the algorithm is demonstrated by the comparative analysis of suggested algorithms on the benchmark and real world problems.

  4. Clinical Trial and Research Study Recruiters' Verbal Communication Behaviors.

    PubMed

    Morgan, Susan E; Mouton, Ashton; Occa, Aurora; Potter, Jonell

    2016-07-01

    The lack of accrual to research studies and clinical trials is a persistent problem with serious consequences: Advances in medical science depend on the participation of large numbers of people, including members of minority and underserved populations. The current study examines a critical determinant of accrual: the approach of patients by professional recruiters who request participation in research studies and clinical trials. Findings indicate that recruiters use a number of verbal strategies in the communication process, including translating study information (such as simplifying, using examples, and substituting specific difficult or problematic words), using linguistic reframing or metaphors, balancing discussions of research participation risks with benefits, and encouraging potential participants to ask questions. The identification of these verbal strategies can form the basis of new communication protocols that will help medical and nonmedical professionals communicate more clearly and effectively with patients and other potential participants about research studies and clinical trials, which should lead to increased accrual in the future. PMID:27259754

  5. Characterization of the Context of Drug Concepts in Research Protocols: An Empiric Study to Guide Ontology Development

    PubMed Central

    Cimino, James J.; Huser, Vojtech

    2015-01-01

    We examined a large body of research study documents (protocols) to identify mentions of drug concepts and established base concepts and roles needed to characterize the semantics of these instances. We found these concepts in three general situations: background knowledge about the drug, study procedures involving the drug, and other roles of the drug in the study. We identified 18 more specific contexts (e.g., adverse event information, administration and dosing of the drug, and interactions between the study drug and other drugs). The ontology was validated against a test set of protocol documents from NIH and ClinicalTrial.gov. The goal is to support the automated extraction of drug information from protocol documents to support functions such as study retrieval, determination of subject eligibility, generation of order sets, and creation of logic for decision support alerts and reminders. Further work is needed to formally extend existing ontologies of clinical research. PMID:26958176

  6. Comparative study of clinical pulmonary surfactants using atomic force microscopy

    PubMed Central

    Zhang, Hong; Fan, Qihui; Wang, Yi E.; Neal, Charles R.; Zuo, Yi Y.

    2016-01-01

    Clinical pulmonary surfactant is routinely used to treat premature newborns with respiratory distress syndrome, and has shown great potential in alleviating a number of neonatal and adult respiratory diseases. Despite extensive study of chemical composition, surface activity, and clinical performance of various surfactant preparations, a direct comparison of surfactant films is still lacking. In this study, we use atomic force microscopy to characterize and compare four animal-derived clinical surfactants currently used throughout the world, i.e., Survanta, Curosurf, Infasurf and BLES. These modified-natural surfactants are further compared to dipalmitoyl phosphatidylcholine (DPPC), a synthetic model surfactant of DPPC:palmitoyl-oleoyl phosphatidylglycerol (POPG) (7:3), and endogenous bovine natural surfactant. Atomic force microscopy reveals significant differences in the lateral structure and molecular organization of these surfactant preparations. These differences are discussed in terms of DPPC and cholesterol contents. We conclude that all animal-derived clinical surfactants assume a similar structure of multilayers of fluid phospholipids closely attached to an interfacial monolayer enriched in DPPC, at physiologically relevant surface pressures. This study provides the first comprehensive survey of the lateral structure of clinical surfactants at various surface pressures. It may have clinical implications on future application and development of surfactant preparations. PMID:21439262

  7. Bayes and empirical Bayes methods for reduced rank regression models in matched case-control studies

    PubMed Central

    Zhou, Qin; Lan, Qing; Rothman, Nathaniel; Langseth, Hilde; Engel, Lawrence S.

    2015-01-01

    Summary Matched case-control studies are popular designs used in epidemiology for assessing the effects of exposures on binary traits. Modern studies increasingly enjoy the ability to examine a large number of exposures in a comprehensive manner. However, several risk factors often tend to be related in a non-trivial way, undermining efforts to identify the risk factors using standard analytic methods due to inflated type I errors and possible masking of effects. Epidemiologists often use data reduction techniques by grouping the prognostic factors using a thematic approach, with themes deriving from biological considerations. We propose shrinkage type estimators based on Bayesian penalization methods to estimate the effects of the risk factors using these themes. The properties of the estimators are examined using extensive simulations. The methodology is illustrated using data from a matched case-control study of polychlorinflated biphenyls in relation to the etiology of non-Hodgkin’s lymphoma. PMID:26575519

  8. Toward an integrative model of doping use: an empirical study with adolescent athletes.

    PubMed

    Lazuras, Lambros; Barkoukis, Vassileios; Tsorbatzoudis, Haralambos

    2015-02-01

    The present study assessed adolescent athletes' intentions toward doping by using an integrative theoretical model. Overall, 650 adolescent athletes from team and individual sports completed an anonymous structured questionnaire including demographic information, social desirability, achievement goals, motivational regulations, sportspersonship orientations, social cognitive variables, and anticipated regret. Hierarchical regression analysis showed that the integrative model predicted 57.2% of the variance in doping intentions. Social cognitive variables and anticipated regret directly predicted doping intentions. Anticipated regret added 3% incremental variance on top of other predictors. Multiple mediation analyses showed that the effects of achievement goals on intentions were mediated by self-efficacy beliefs, whereas the effects of sportspersonship were mediated by attitudes and anticipated regret. The present study confirmed the dual structure of an integrative model of doping intentions and further highlighted the role of anticipated regret in the study of adolescent doping use. PMID:25730890

  9. Bayes and empirical Bayes methods for reduced rank regression models in matched case-control studies.

    PubMed

    Satagopan, Jaya M; Sen, Ananda; Zhou, Qin; Lan, Qing; Rothman, Nathaniel; Langseth, Hilde; Engel, Lawrence S

    2016-06-01

    Matched case-control studies are popular designs used in epidemiology for assessing the effects of exposures on binary traits. Modern studies increasingly enjoy the ability to examine a large number of exposures in a comprehensive manner. However, several risk factors often tend to be related in a nontrivial way, undermining efforts to identify the risk factors using standard analytic methods due to inflated type-I errors and possible masking of effects. Epidemiologists often use data reduction techniques by grouping the prognostic factors using a thematic approach, with themes deriving from biological considerations. We propose shrinkage-type estimators based on Bayesian penalization methods to estimate the effects of the risk factors using these themes. The properties of the estimators are examined using extensive simulations. The methodology is illustrated using data from a matched case-control study of polychlorinated biphenyls in relation to the etiology of non-Hodgkin's lymphoma. PMID:26575519

  10. Visual Task Demands and the Auditory Mismatch Negativity: An Empirical Study and a Meta-Analysis

    PubMed Central

    Wiens, Stefan; Szychowska, Malina; Nilsson, Mats E.

    2016-01-01

    Because the auditory system is particularly useful in monitoring the environment, previous research has examined whether task-irrelevant, auditory distracters are processed even if subjects focus their attention on visual stimuli. This research suggests that attentionally demanding visual tasks decrease the auditory mismatch negativity (MMN) to simultaneously presented auditory distractors. Because a recent behavioral study found that high visual perceptual load decreased detection sensitivity of simultaneous tones, we used a similar task (n = 28) to determine if high visual perceptual load would reduce the auditory MMN. Results suggested that perceptual load did not decrease the MMN. At face value, these nonsignificant findings may suggest that effects of perceptual load on the MMN are smaller than those of other demanding visual tasks. If so, effect sizes should differ systematically between the present and previous studies. We conducted a selective meta-analysis of published studies in which the MMN was derived from the EEG, the visual task demands were continuous and varied between high and low within the same task, and the task-irrelevant tones were presented in a typical oddball paradigm simultaneously with the visual stimuli. Because the meta-analysis suggested that the present (null) findings did not differ systematically from previous findings, the available evidence was combined. Results of this meta-analysis confirmed that demanding visual tasks reduce the MMN to auditory distracters. However, because the meta-analysis was based on small studies and because of the risk for publication biases, future studies should be preregistered with large samples (n > 150) to provide confirmatory evidence for the results of the present meta-analysis. These future studies should also use control conditions that reduce confounding effects of neural adaptation, and use load manipulations that are defined independently from their effects on the MMN. PMID:26741815

  11. Empirical study of a unidirectional dense crowd during a real mass event

    NASA Astrophysics Data System (ADS)

    Zhang, X. L.; Weng, W. G.; Yuan, H. Y.; Chen, J. G.

    2013-06-01

    Many tragic crowd disasters have happened across the world in recent years, such as the Phnom Penh stampede in Cambodia, crowd disaster in Mina/Makkah, and the Love Parade disaster in Germany, showing that management of mass events is a tough task for organizers. The study of unidirectional flow, one of the most common forms of motion in mass activities, is essential for safe organization of such events. In this paper, the properties of unidirectional flow in a crowded street during a real mass event in China are quantitatively investigated with sophisticated active infrared counters and an image processing method. A complete dataset of flow rates during the whole celebration is recorded, and a time series analysis gives new insight into such activities. The spatial analysis shows that the velocity and density of the crowd are inhomogeneous due to the boundary effect, whereas the flux is uniform. The estimated capacity of the street indicates that the maximum flow rate under normal condition should be between 1.73 and 1.98 /m/s, which is in good agreement with several field studies available in the existing literature. In consideration of the significant deviation among different studies, fundamental diagrams of dense crowds are also re-verified, and the results here are consistent with those from other field studies of unidirectional flow, but different from the bidirectional and experimental results. It is suggested that the data from multidirectional flow and experiments cannot be directly applied to unidirectional dense flow in a real mass event. The results also imply that the density of a similar unidirectional marching crowd should be controlled to be under 5 /m2, which can produce optimal efficiency and have more possibility to ensure safety. The field study data given here provide a good example of a database for crowd studies.

  12. The behavioral consequences of service quality: an empirical study in the Chinese retail pharmacy industry.

    PubMed

    Chen, Yuwen; Fu, Frank Q

    2015-01-01

    This study focuses on the impacts of service quality and examines the mediating effects of customer satisfaction and customer loyalty on willingness to pay more. The authors collected survey data from 479 actual retail pharmacy customers in China and used the structural equation modeling approach to test the hypotheses. The results reveal six dimensions of service quality and the differential impact of these dimensions on customer satisfaction and behavioral intentions. This study contributes to the existing literature by exploring the dimensionality of the service quality construct and mediating effects of customer satisfaction and customer loyalty in a non-Western setting. PMID:25751316

  13. [Financial conflict of interest in clinical psychiatry studies: a review].

    PubMed

    Ulaş, Halis; Binbay, Tolga; Alptekin, Köksal

    2008-01-01

    Pharmaceutical industry revenues from global pharmaceutical sales have increased 7% to $602 billion in 2005. Approximately 15% of these revenues were spent on clinical research and drug development studies. Because of the huge budget allocated to research and development studies the number of studies being conducted by pharmaceutical companies has increased. The impact of the pharmaceutical industry on clinical trials has been affected by financial conflicts of interest between researchers and the industry. Conflict of interest refers to a situation in which it appears that a researcher's personal financial interest could significantly affect the design, conduct, and/or reporting of such research. Financial conflict of interest has been reported to be frequent in clinical trials in general medicine. It is estimated that 89%-98% of comparative drug treatment studies are funded by pharmaceutical companies. It was reported that favorable outcomes for the firms conducting these studies were significantly more common in industry-funded studies than in non-industry funded ones. These biased outcomes were due to conscious or unconscious decisions about the design, data analysis, and publishing of the studies. Biased outcomes of industry-funded studies have diminished the integrity of academic institutions, pharmaceutical companies, researchers, and scientific journals; therefore, various precautions have been taken in order to reduce the effect of conflict of interest on study outcomes. The aim of this review was to evaluate the effect of conflict of interest on outcomes in clinical psychiatry studies. PMID:19110984

  14. Product and Process Perspectives: an Empirical Study of Explicitation in Chinese-English Translation

    ERIC Educational Resources Information Center

    Fan, Zhewei

    2012-01-01

    Product-and process-oriented, this dissertation focuses on both the explicitness in translated texts and the implementation of explicitation in Chinese-English translation. In doing so, it provides a new cognitive framework for understanding explicitation as a strategic process. A specially designed study of the translation process facilitates the…

  15. Generic Behavioural Criteria of Managerial Effectiveness: An Empirical and Comparative Case Study of UK Local Government

    ERIC Educational Resources Information Center

    Hamlin, Robert G.; Serventi, Susan A.

    2008-01-01

    Purpose: The purpose of this paper is to present the findings of a "partnership-research" study of effective and ineffective managerial behaviour within the "local government" setting of the Wolverhampton City Council Social Care Department, and to describe how the research supports and challenges the organisation's existing "leadership and…

  16. An Empirical Evaluation of Critical Factors Influencing Learner Satisfaction in Blended Learning: A Pilot Study

    ERIC Educational Resources Information Center

    Chen, Won Sun; Yao, Adrian Yong Tat

    2016-01-01

    Blended learning, a convergence of e-learning approach and face-to-face learning, has been regarded as a new paradigm in modern education. The degree of learners' satisfaction with blended learning played a crucial role in evaluating the effectiveness of blended learning adoption. Therefore, this study examined the primary factors affecting…

  17. Identity Dystopias, Empire Framing and Theoretical Hegemonies: Two Case Studies, India and Ireland

    ERIC Educational Resources Information Center

    Allender, Tim; O'Donoghue, Tom

    2014-01-01

    This article explores the connections between official contemporary identity formation and colonial pasts. Using the case studies of India and Ireland the article explores how different traditions of theorisation are powerful in these formations. India and Ireland were two colonial domains that had many linkages outside the ambit of the British.…

  18. An Empirical Study of the Zajonc-Markus Hypothesis for Achievement Test Score Declines.

    ERIC Educational Resources Information Center

    Melican, Gerald J.; Feldt, Leonard S.

    1980-01-01

    Zajonc has proposed that the decline in high school achievement since 1965 can be explained by the trend from 1947 to 1962 toward larger, closer-spaced families. This study tested this theory with data on students in Iowa high schools. Overall, the results raise doubt about this hypothesis. (Author/CTM)

  19. An Empirical Study on the Application of Cooperative Learning to English Listening Classes

    ERIC Educational Resources Information Center

    Han, Min

    2015-01-01

    Cooperative learning is a strategic instructional system applied by many educators the world over. Researchers of cooperative learning have carried out the study in this field and proved that cooperative learning can create a more interesting and relaxed learning atmosphere. It is generally acknowledged that cooperative learning can reduce…

  20. Supervision and Satisfaction among School Psychologists: An Empirical Study of Professionals in Victoria, Australia

    ERIC Educational Resources Information Center

    Thielking, Monica; Moore, Susan; Jimerson, Shane R.

    2006-01-01

    This study examined the supervision arrangements and job satisfaction among school psychologists in Victoria, Australia. Participation in professional supervision was explored in relation to the type of employment and job satisfaction. The results revealed that the frequency of participation in supervision activities was less than optimal, with…

  1. Active versus Passive Teaching Styles: An Empirical Study of Student Learning Outcomes

    ERIC Educational Resources Information Center

    Michel, Norbert; Cater, John James, III; Varela, Otmar

    2009-01-01

    This study compares the impact of an active teaching approach and a traditional (or passive) teaching style on student cognitive outcomes. Across two sections of an introductory business course, one class was taught in an active or nontraditional manner, with a variety of active learning exercises. The second class was taught in a passive or…

  2. The Relationship of Teacher-Personality Type to Grading Freshman Composition Essays: An Empirical Study.

    ERIC Educational Resources Information Center

    Covner, Thelma Crockin

    To gain insight into the evaluation of college freshman compositions, a study explored the relationship between the personality type of the instructor and the grades assigned to essays written by freshman composition students. The sample comprised 23 college instructors who answered a short questionnaire, graded the same expository essay, and…

  3. An Empirical Study of Student Science Achievement in the People's Republic of China.

    ERIC Educational Resources Information Center

    Wang, Jianjun

    Most comparative studies about China were challenged by many sinologists and educators for not grounding on representative samples. This research is mainly based on a Chinese data base collected from a random sample of more than 10,000 9th-grade students in the Second International Association for the Evaluation of Educational Achievement (IEA)…

  4. Global Culture, Learning Style, and Outcome: An Interdisciplinary Empirical Study of International University Students

    ERIC Educational Resources Information Center

    Strang, Kenneth David

    2010-01-01

    The study examined 2500 business degree students from 21 countries, enrolled at an Australian university, using a survey to assess learning style, which was integrated into a global culture taxonomy. The research hypothesis was that academic outcome could be explained through an interdisciplinary model, by integrating proven theories from…

  5. An Empirical Study of the Personality Characteristics of Internet Sex Offenders

    ERIC Educational Resources Information Center

    Tomak, Sheri; Weschler, Frederick S.; Ghahramanlou-Holloway, Marjan; Virden, Thomas; Nademin, Mahsaw Elicia

    2009-01-01

    The present study evaluated the personality characteristics and psychopathology of internet sex offenders (ISOs) using the Minnesota Multiphasic Personality Inventory, Second Edition (MMPI-2) to determine whether ISO personality profiles are different to those of general sex offenders (GSOs; e.g. child molesters and rapists). The ISOs consisted of…

  6. Exploration of Social Capital and Knowledge Sharing: An Empirical Study on Student Virtual Teams

    ERIC Educational Resources Information Center

    Liu, Ying Chieh; Li, FengChia

    2012-01-01

    Although research on virtual teams is becoming more popular, there is a gap in the understanding of how social capital affects knowledge sharing and creating, and their impacts on virtual team performance. To fill in this gap, this study establishes a framework by incorporating social capital with the SECI model and further examines it with an…

  7. Are You Ready for Knowledge Sharing? An Empirical Study of Virtual Communities

    ERIC Educational Resources Information Center

    Hung, Shiu-Wan; Cheng, Min-Jhih

    2013-01-01

    This study aimed to explore the relationship between knowledge sharing intentions and the perceptions of individual technology users who are members of virtual communities. We characterized learners' perceptions of new technological products or services by including both an individual's psychological state of readiness to accept technology and…

  8. Task Characteristics and Learning Potentials--Empirical Results of Three Diary Studies on Workplace Learning

    ERIC Educational Resources Information Center

    Rausch, Andreas

    2013-01-01

    Most learning in the workplace occurs while pursuing working rather than learning goals. The studies at hand aimed to identify task characteristics that foster learning in the workplace. Task characteristics are supposed to exert a major effect on the learning potential. However, the fact that learning is more often than not a rather unconscious…

  9. Communication Privacy Disclosure Management: An Empirical Study of Socialization Support in a Pseudo-Online Course

    ERIC Educational Resources Information Center

    Heo, Misook

    2011-01-01

    This study investigated the boundaries of online learners' information disclosure, relationship building, interpersonal integration, and motivation by drawing upon the theoretical frameworks of the social information processing and communication privacy management theories and the hyperpersonal model. A total of 103 students from a higher…

  10. The Efficiency of Different Online Learning Media--An Empirical Study

    ERIC Educational Resources Information Center

    Köbler, Franziska J.; Nitzschner, Marco M.

    2014-01-01

    In the current study, it was examined whether successful learning is related to using different types of media. We compared the comprehension of an economic concept in novices (N = 82) under three conditions: a Wikipedia article, a funny, and a serious YouTube video. The media were presented in English which is a foreign language to most of the…

  11. An Empirical Study of the School Zone Law in Three Cities in Massachusetts.

    ERIC Educational Resources Information Center

    Brownsberger, William N.; Aromaa, Susan

    This study of the 1989 Massachusetts' School Anti-Drug law reviewed 443 drug dealing cases in three cities. After selecting cities and drug dealing cases, researchers reviewed District Attorney case files and extracted selected data items (primarily from police reports). They mapped incident locations, schools, and parks in the cities; computed…

  12. Graduates' Personality Characteristics and Labor Market Entry an Empirical Study among Dutch Economics Graduates

    ERIC Educational Resources Information Center

    Semeijn, J.; Boone, C.; van der Velden, R.; van Witteloostuijn, A.

    2005-01-01

    In this study, we explore the value of personality characteristics in explaining success in labor market entry with a sample of graduates in economics from Maastricht University (the Netherlands). Specifically, the paper addresses the following twofold research question: does personality explain labor market outcomes, and how much weight does this…

  13. Assessing Mobile Learning Readiness in Saudi Arabia Higher Education: An Empirical Study

    ERIC Educational Resources Information Center

    Aljuaid, Nada Mansour F.; Alzahrani, Mohammed Ali Rajab; Islam, A. Y. M. Atiquil

    2014-01-01

    Mobile learning has been introduced for quite some time now at Taif University. However, there is no research conducted to measure the readiness of mobile learning within its context. As such, the aim of this study is to assess the lecturers' readiness for mobile learning in higher education in terms of perceived usefulness and perceived ease of…

  14. An Empirical Study of Post-Branzburg Cases Involving Newsmen's Privilege.

    ERIC Educational Resources Information Center

    Mehra, Achal

    Nine years after the 1972 Supreme Court ruling in *Branzburg v. Hayes" that journalists enjoy no constitutional privilege to withhold the names of sources and to conceal information from grand jury proceedings, a study was conducted to determine the courts' attitudes toward journalists' privilege and to test commonly held beliefs about its status…

  15. An Empirical Study of Industrial Engineering and Management Curriculum Reform in Fostering Students' Creativity

    ERIC Educational Resources Information Center

    Chen, Chi-Kuang; Jiang, Bernard C.; Hsu, Kuang-Yiao

    2005-01-01

    The objective of this paper is to examine the effectiveness of a creativity-fostering program in industrial engineering and management (IE&M) curriculum reform. Fostering creativity in students has become a crucial issue in industrial engineering education. In a survey of previous studies, we found few on IE&M curriculum reform. In particular, no…

  16. An Empirical Study of Hospitality Management Student Attitudes toward Group Projects: Instructional Factors and Team Problems

    ERIC Educational Resources Information Center

    Choi, Youngsoo; Ro, Heejung

    2012-01-01

    The development of positive attitudes in team-based work is important in management education. This study investigates hospitality students' attitudes toward group projects by examining instructional factors and team problems. Specifically, we examine how the students' perceptions of project appropriateness, instructors' support, and evaluation…

  17. Sex Ratio at Birth and Infant Mortality Rate in China: An Empirical Study

    ERIC Educational Resources Information Center

    Lai, Denjian

    2005-01-01

    In this article, we used the data from the last three population censuses of China in 1982, 1990 and 2000, to study the dynamics of the sex ratio at birth and the infant mortality rate in China. In the late 1970s, China started its economic reform and implemented many family planning programs. Since then there has been great economic development…

  18. Using Calibrated Exemplars in the Teacher-Assessment of Writing: An Empirical Study

    ERIC Educational Resources Information Center

    Heldsinger, Sandra A.; Humphry, Stephen M.

    2013-01-01

    Background: Many in education argue for the importance of incorporating teacher judgements in the assessment and reporting of student performance. Advocates of such an approach are cognisant, though, that obtaining a satisfactory level of consistency in teacher judgements poses a challenge. Purpose: This study investigates the extent to which the…

  19. School Grades and Responsibility for Younger Siblings: An Empirical Study of the "Teaching Function."

    ERIC Educational Resources Information Center

    Smith, Thomas Ewin

    1984-01-01

    A study based on the confluence model of family effects upon intellectual growth found a negative relationship between grades and the number of older siblings for Whites but not for Blacks and a negative relationship between the grades of Blacks and responsibility for younger siblings. (CMG)

  20. Comparing Achievement between K-8 and Middle Schools: A Large-Scale Empirical Study

    ERIC Educational Resources Information Center

    Byrnes, Vaughan; Ruby, Allen

    2007-01-01

    This study compares middle schools to K-8 schools, as well as to newly formed K-8 schools that are part of a K-8 conversion policy. The outcome is student achievement, and our sample includes 40,883 eighth-grade students from 95 schools across five cohorts. The analysis uses multilevel modeling to account for student, cohort, and school-level…

  1. Attitudes towards the Euro: An Empirical Study Based on the German Socio-Economic Panel (SOEP)

    ERIC Educational Resources Information Center

    Isengard, Bettina; Schneider, Thorsten

    2007-01-01

    This paper investigates changing attitudes towards the euro over time in Germany using longitudinal micro-data from the German Socio Economic Panel Study. We observe that a large part of the German population was worried about the new currency both before and after its introduction. Social psychological theories provide insight into these…

  2. Online Learning in Management Education: An Empirical Study of the Role of Personality Traits

    ERIC Educational Resources Information Center

    Varela, Otmar E.; Cater, John James, III; Michel, Norbert

    2012-01-01

    In this study we seek to better understand the outcomes of online education by observing the role of learners' personality traits. Under the premise that the behaviors that maximize learning are contingent on the delivery method, we compared learning outcomes of students participating in four sections of an undergraduate principles of management…

  3. The Role of Structural Characteristics in Problematic Video Game Play: An Empirical Study

    ERIC Educational Resources Information Center

    King, Daniel L.; Delfabbro, Paul H.; Griffiths, Mark D.

    2011-01-01

    The research literature suggests that the structural characteristics of video games may play a considerable role in the initiation, development and maintenance of problematic video game playing. The present study investigated the role of structural characteristics in video game playing behaviour within a sample of 421 video game players aged…

  4. Promoting Political Competence and Engagement in College Students: An Empirical Study

    ERIC Educational Resources Information Center

    Beaumont, Elizabeth; Colby, Anne; Ehrlich, Thomas; Torney-Purta, Judith

    2006-01-01

    Political participation is critical for the legitimacy of democracy, yet we know surprisingly little about how political competencies develop and can be promoted in young adults. Many studies show low levels of political activity among young Americans, including college students and recent graduates. Although this is widely recognized as a…

  5. The Linguistic Advantage of the Intellectually Gifted Child: An Empirical Study of Spontaneous Speech

    ERIC Educational Resources Information Center

    Hoh, Pau-San

    2005-01-01

    This study compares the linguistic development of a gifted bilingual child from birth to 7 with that of subjects in first language acquisition research. The aspects analyzed are phonology, morphology (word formation), lexicon, modality (encoding of speaker's attitude towards the truthfulness of a proposition), syntax (sentence construction),…

  6. The Importance of Civic Responsibility in Higher Performing Middle Schools: An Empirical Study

    ERIC Educational Resources Information Center

    Wilcox, Kristen C.

    2011-01-01

    In this case study, a district-wide focus on the development of civic responsibility is seen as an important component in the success of higher performing middle schools. Salient features of best practice were gathered from teacher and administrator interviews and documentary evidence in 10 higher performing, yet "beating the odds" schools, and…

  7. Assessing the Usability of University Websites: An Empirical Study on Namik Kemal University

    ERIC Educational Resources Information Center

    Mentes, S. Ahmet; Turan, Aykut H.

    2012-01-01

    Web sites are emerging as a key component of an organization's survival in our ever globalizing competitive world. Usability of a web site has assumed a great deal of importance in terms of satisfying web site users' needs and expectations. The aim of the study is to evaluate and to explore the usability level of Namik Kemal University (NKU)…

  8. Emotional Competencies in Geriatric Nursing: Empirical Evidence from a Computer Based Large Scale Assessment Calibration Study

    ERIC Educational Resources Information Center

    Kaspar, Roman; Hartig, Johannes

    2016-01-01

    The care of older people was described as involving substantial emotion-related affordances. Scholars in vocational training and nursing disagree whether emotion-related skills could be conceptualized and assessed as a professional competence. Studies on emotion work and empathy regularly neglect the multidimensionality of these phenomena and…

  9. Application of Open-Source Enterprise Information System Modules: An Empirical Study

    ERIC Educational Resources Information Center

    Lee, Sang-Heui

    2010-01-01

    Although there have been a number of studies on large scale implementation of proprietary enterprise information systems (EIS), open-source software (OSS) for EIS has received limited attention in spite of its potential as a disruptive innovation. Cost saving is the main driver for adopting OSS among the other possible benefits including security…

  10. An Empirical Study on Behavioural Intention to Reuse E-Learning Systems in Rural China

    ERIC Educational Resources Information Center

    Li, Yan; Duan, Yanqing; Fu, Zetian; Alford, Philip

    2012-01-01

    The learner's acceptance of e-learning systems has received extensive attention in prior studies, but how their experience of using e-learning systems impacts on their behavioural intention to reuse those systems has attracted limited research. As the applications of e-learning are still gaining momentum in developing countries, such as China,…

  11. Variations of In-Service Training for Primary Mathematics Teachers: An Empirical Study

    ERIC Educational Resources Information Center

    Selter, Christoph; Gräsel, Cornelia; Reinold, Martin; Trempler, Kati

    2015-01-01

    Previous findings indicate that the effectiveness of in-service teacher training can be increased by a (pedagogical) content knowledge orientation on the one hand and the stimulation of cooperation among teachers on the other. In this paper, three versions of a multi-phase training program were compared in a quasi-experimental field study with a…

  12. An Empirical Study of Student Attitudes toward Acceptance of Online Instruction and Distance Learning

    ERIC Educational Resources Information Center

    Nguyen, Dat-Dao; Zhang, Yue

    2011-01-01

    This study investigates to what extent student attitudes toward acceptance of online instruction and Distance Learning are affected by determinants such as demographics, learning environment, learning domains, delivery methods, and web-based instructional technology. Logistic Regression and Discriminant Analysis use statistically significant…

  13. Asian Students' Voices: An Empirical Study of Asian Students' Learning Experiences at a New Zealand University

    ERIC Educational Resources Information Center

    Campbell, Jacqui; Li, Mingsheng

    2008-01-01

    More than 85% of the international students in New Zealand are Asian in origin. The level of satisfaction of Asian international students with their learning experiences in New Zealand has been of enormous concern for the New Zealand export education industry. The results of this current research, based on a qualitative research study conducted at…

  14. L1 Use during L2 Writing: An Empirical Study of a Complex Phenomenon

    ERIC Educational Resources Information Center

    van Weijen, Daphne; van den Bergh, Huub; Rijlaarsdam, Gert; Sanders, Ted

    2009-01-01

    This study examined writers' use of their first language (L1) while writing in their second language (L2). Twenty students each wrote four short argumentative essays in their L1 (Dutch) and four in their L2 (English) under think-aloud conditions. We analysed whether L1 use varied between writers and tasks, and whether it was related to general…

  15. A Survey and Empirical Study of Virtual Reference Service in Academic Libraries

    ERIC Educational Resources Information Center

    Mu, Xiangming; Dimitroff, Alexandra; Jordan, Jeanette; Burclaff, Natalie

    2011-01-01

    Virtual Reference Services (VRS) have high user satisfaction. The main problem is its low usage. We surveyed 100 academic library web sites to understand how VRS are presented. We then conducted a usability study to further test an active VRS model regarding its effectiveness.

  16. An Empirical Study on the Effect of Work/Life Commitment to Work-Life Conflict

    NASA Astrophysics Data System (ADS)

    Ma, Li; Yin, Jie-lin

    This study examined the relation between work and life orientation and work interfere with personal life or personal life interfere with work of employees in China. Cluster analysis results showed that there are four profiles of orientation: work orientation, life orientation, integration and disengagement orientation. There are significant differences in work interfere personal life and personal life interfere work between different profiles.

  17. High Performance Work System, HRD Climate and Organisational Performance: An Empirical Study

    ERIC Educational Resources Information Center

    Muduli, Ashutosh

    2015-01-01

    Purpose: This paper aims to study the relationship between high-performance work system (HPWS) and organizational performance and to examine the role of human resource development (HRD) Climate in mediating the relationship between HPWS and the organizational performance in the context of the power sector of India. Design/methodology/approach: The…

  18. Contributions to the Empirical Study of Immediacy in the Pedagogical Relationship through Self-Narratives

    ERIC Educational Resources Information Center

    Manarte, Joana; Lopes, Amélia; Pereira, Fátima

    2014-01-01

    Pedagogical communication is an action wherein the body, being a part of a relational whole, performs a fundamental role. A bibliographical survey of studies on the interaction between teacher and student confirms that there is a strong correlation between the teacher's nonverbal behavior and the students' level of motivation and…

  19. Empirical Study of Motivators and Barriers of Teacher Online Knowledge Sharing

    ERIC Educational Resources Information Center

    Hew, Khe Foon; Hara, Noriko

    2007-01-01

    The focus of this study was to understand knowledge flows among teachers by examining what types of knowledge was shared by teachers, as well as what motivates or hinders teachers to share knowledge online. We examined an electronic mailing list (listserv) supporting a community of practice of literacy teachers. Data were gathered on the teachers…

  20. An Empirical Typology of Residential Care/Assisted Living Based on a Four-State Study

    ERIC Educational Resources Information Center

    Park, Nan Sook; Zimmerman, Sheryl; Sloane, Philip D.; Gruber-Baldini, Ann L.; Eckert, J. Kevin

    2006-01-01

    Purpose: Residential care/assisted living describes diverse facilities providing non-nursing home care to a heterogeneous group of primarily elderly residents. This article derives typologies of assisted living based on theoretically and practically grounded evidence. Design and Methods: We obtained data from the Collaborative Studies of Long-Term…