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Sample records for commission cea 2005-2006

  1. Expanding Access and Increasing Success in Postsecondary Education for Arizonans. Arizona Commission for Postsecondary Education (ACPE) Fiscal Year 2005-2006 Annual Report

    ERIC Educational Resources Information Center

    Arizona Commission for Postsecondary Education, 2006

    2006-01-01

    The work of the Arizona Commission for Postsecondary Education (ACPE) is guided by a 5-year strategic plan. The purpose of the plan is to provide focus for the activity of this small agency and its seven staff members in order to increase productivity and impact in the areas of its statutory authority. The mission and goals were accepted by…

  2. Update: Fusarium Keratitis - United States, 2005 - 2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This report describes the results of a Fusarium keratitis outbreak investigation being conducted by the United States Centers for Disease Control and Prevention. The epidemiological data indicate that the 2005-2006 outbreaks of corneal infections within the United States are linked to the use of on...

  3. Training and Certification Program for Certified Energy Auditors (CEA) and Certified Building Commissioning Professionals (CBCP)

    SciTech Connect

    Kent, Bill

    2012-08-24

    The Association of Energy Engineers (AEE) has offered energy efficiency training and certification programs for over 30 years. During that time AEE has certified more than 22,000 professionals. All of our certification programs are the result of extensive industry research and program development and oversight by certification boards. For this project award, AEE proposed to work with the Department of Energy to utilize and extend existing industry recognized Certified Energy Auditor (CEA) and Certified Building Commissioning Professional (CBCP) programs under this Training Program Development Announcement. These expanded training programs will have significant impact in training professionals for building commissioning and energy auditing to achieve the goal of bringing existing buildings up to their optimal energy performance potential and ensuring that new buildings maintain their expected optimal level of performance. The goals and objectives of the training development project were achieved with the development of new training programs that are now being offered as self-sustaining commercial training and certification programs. These new programs are training and certifying professionals who are accomplishing the goal of increasing building energy performance in both existing and new buildings.

  4. Student Charges and Financial Aid 2005-2006

    ERIC Educational Resources Information Center

    American Association of State Colleges and Universities, 2006

    2006-01-01

    For the second consecutive year, the economy and state fiscal conditions continued to improve, offering some relief in student charges and financial aid at public colleges and universities in 2005-2006. Tuition increases have shrunk to single-digits, but concern is still high regarding enrollment growth, employee compensation and benefits and…

  5. DOE Hydropower Program Biennial Report for FY 2005-2006

    SciTech Connect

    Sale, Michael J.; Cada, Glenn F.; Acker, Thomas L.; Carlson, Thomas; Dauble, Dennis D.; Hall, Douglas G.

    2006-07-01

    This report describes the progress of the R&D conducted in FY 2005-2006 the under four program areas at the time: (1) Advanced Hydropower Technology (Large Turbine Field Testing, Water Use Optimization, and Improved Mitigation Practices); (2) Supporting Research and Testing (Environmental Performance Testing Methods, Computational and Physical Modeling, Instrumentation and Controls, and Environmental Analysis); (3) Systems Integration and Technology Acceptance (Hydro/Wind Integration, National Hydropower Collaborative, and Integration and Communications); and (4) Supporting Engineering and Analysis (Valuation Methods and Assessments and Characterization of Innovative Technology).

  6. Food Patterns Equivalents Database 2005-2006: Methodology and User Guide

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The purpose of developing the Food Patterns Equivalents Database (FPED) 2005-2006 is to convert the 7,000+ foods in the Food and Nutrients Database for Dietary Studies (FNDDS) 3.0 used for the What We Eat in America, National Health and Nutrition Examination Survey (WWEIA, NHANES) 2005-2006, to USDA...

  7. DOE Hydropower Program Biennial Report for FY 2005-2006

    SciTech Connect

    Sale, Michael J; Cada, Glenn F; Acker, Thomas L.; Carlson, Thomas; Dauble, Dennis D.; Hall, Douglas G.

    2006-07-01

    SUMMARY The U.S. Department of Energy (DOE) Hydropower Program is part of the Office of Wind and Hydropower Technologies, Office of Energy Efficiency and Renewable Energy. The Program's mission is to conduct research and development (R&D) that will increase the technical, societal, and environmental benefits of hydropower. The Department's Hydropower Program activities are conducted by its national laboratories: Idaho National Laboratory (INL) [formerly Idaho National Engineering and Environmental Laboratory], Oak Ridge National Laboratory (ORNL), Pacific Northwest National Laboratory (PNNL), and National Renewable Energy Laboratory (NREL), and by a number of industry, university, and federal research facilities. Programmatically, DOE Hydropower Program R&D activities are conducted in two areas: Technology Viability and Technology Application. The Technology Viability area has two components: (1) Advanced Hydropower Technology (Large Turbine Field Testing, Water Use Optimization, and Improved Mitigation Practices) and (2) Supporting Research and Testing (Environmental Performance Testing Methods, Computational and Physical Modeling, Instrumentation and Controls, and Environmental Analysis). The Technology Application area also has two components: (1) Systems Integration and Technology Acceptance (Hydro/Wind Integration, National Hydropower Collaborative, and Integration and Communications) and (2) Supporting Engineering and Analysis (Valuation Methods and Assessments and Characterization of Innovative Technology). This report describes the progress of the R&D conducted in FY 2005-2006 under all four program areas. Major accomplishments include the following: Conducted field testing of a Retrofit Aeration System to increase the dissolved oxygen content of water discharged from the turbines of the Osage Project in Missouri. Contributed to the installation and field testing of an advanced, minimum gap runner turbine at the Wanapum Dam project in Washington. Completed

  8. Key Performance Criteria Affecting the Most the Safety of a Nuclear Waste Long Term Storage : A Case Study Commissioned by CEA

    SciTech Connect

    Marvy, A.; Lioure, A; Heriard-Dubreuil, G.; Gadbois, S.; Schneider, T.; Schieber, C.

    2003-02-24

    As part of the work scope set in the French law on high level long lived waste R&D passed in 1991, CEA is conducting a research program to establish the scientific basis and assess the feasibility of long term storage as an option for the safe management of nuclear waste for periods as long as centuries. This goal is a significant departure from the current industrial practice where storage facilities are usually built to last only a few decades. From a technical viewpoint such an extension in time seems feasible provided care and maintenance is exercised. Considering such long periods of time, the risk for Society of loosing oversight and control of such a facility is real, which triggers the question of whether and how long term storage safety can be actually achieved. Therefore CEA commissioned a study (1) in which MUTADIS Consultants (2) and CEPN (3) were both involved. The case study looks into several past and actual human enterprises conducted over significant periods o f time, one of them dating back to the end of the 18th century, and all identified out of the nuclear field. Then-prevailing societal behavior and organizational structures are screened out to show how they were or are still able to cope with similar oversight and control goals. As a result, the study group formulated a set of performance criteria relating to issues like responsibility, securing funds, legal and legislative implications, economic sustainable development, all being areas which are not traditionally considered as far as technical studies are concerned. These criteria can be most useful from the design stage onward, first in an attempt to define the facility construction and operating guiding principles, and thereafter to substantiate the safety case for long term storage and get geared to the public dialogue on that undertaking should it become a reality.

  9. Peak stepping cadence in free-living adults: 2005-2006 NHANES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Analysis of the 2005-2006 National Health and Nutrition Examination Survey (NHANES) accelerometer data provides the descriptive epidemiology of peak 30-minute cadence (defined as the average steps/min recorded for the 30 highest, but not necessarily consecutive, minutes in a day) and peak 1-minute c...

  10. Influenza 2005-2006: vaccine supplies adequate, but bird flu looms.

    PubMed

    Mossad, Sherif B

    2005-11-01

    Influenza vaccine supplies appear to be adequate for the 2005-2006 season, though delivery has been somewhat delayed. However, in the event of a pandemic of avian flu-considered inevitable by most experts, although no one knows when it will happen-the United States would be woefully unprepared. PMID:16315443

  11. Wyoming Community College System Annual Enrollment Report. Academic Year 2005-2006

    ERIC Educational Resources Information Center

    Wyoming Community College Commission, 2006

    2006-01-01

    This report provides annualized enrollment information for the Wyoming community college system for the 2005-2006 academic year. During this year, credit headcount at Wyoming's community colleges increased by 6.1%, the largest annual enrollment increase during the last decade. The report also indicates that the difference between enrollments of…

  12. Domestic Violence in India: Insights from the 2005-2006 National Family Health Survey

    ERIC Educational Resources Information Center

    Kimuna, Sitawa R.; Djamba, Yanyi K.; Ciciurkaite, Gabriele; Cherukuri, Suvarna

    2013-01-01

    This article assesses the prevalence and risk factors of domestic violence in India. The study uses the 2005-2006 India National Family Health Survey-III (NFHS-III) and focuses on the 69,484 ever-married women ages 15 to 49 from all regions, who were administered the domestic violence module. The results show that 31% of respondents experienced…

  13. Soil water signature of the 2005-2006 drought under tallgrass prairie at Fort Reno, Oklahoma

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study examined changes in the seasonal pattern of soil water content under a tall grass prairie in central Oklahoma as a result of the 2005-2006 drought. The seasonal pattern of soil water content in the top 50 cm of the soil profile was minimally impacted by the drought, as this portion of the...

  14. What We Eat In America, NHANES 2005-2006: Documentation and Data Files

    Technology Transfer Automated Retrieval System (TEKTRAN)

    New nationwide dietary intake data were collected in What We Eat In America (WWEIA), National Health and Nutrition Examination Survey (NHANES) for the years 2005-2006 and are now available for public use. Two days of dietary intake data are included for most participants. The dietary interview data ...

  15. 2005-2006 What We Eat In America, NHANES Tables 29-36

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Food Surveys Research Group of the Beltsville Human Nutrition Research Center analyzed dietary data from the What We Eat In America (WWEIA), National Health and Nutrition Examination Survey (NHANES) 2005-2006 and released 8 new tables that add to the current series of 28 data tables already publ...

  16. Mosquito and West Nile virus surveillance in northeast Montana, U.S.A., 2005-2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Mosquito and West Nile virus surveillance was conducted on a National Wildlife Refuge in northeast Montana, 2005-2006, during which outbreaks of WNV in a colony of American white pelicans (Pelecanus erythrorhynchos Gmelin) resulted in juvenile mortality rates of 30 and 31%. During both years, flood...

  17. 2005-2006 What We Eat In America, NHANES Tables 9-28

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Food Surveys Research Group of the Beltsville Human Nutrition Research Center has analyzed dietary data from the What We Eat In America (WWEIA), National Health and Nutrition Examination Survey (NHANES) 2005-2006 and released 20 additional tables that add to the series of 8 summary tables of mea...

  18. 77 FR 42764 - Distribution of the 2005, 2006, 2007 and 2008 Digital Audio Recording Technology Royalty Funds...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Copyright Royalty Board Distribution of the 2005, 2006, 2007 and 2008 Digital Audio Recording Technology... the digital audio recording technology royalty fees in the 2005, 2006, 2007 and 2008 Musical Works... Judges issued an order granting certain claimants' (i.e., Broadcast Music, Inc., the American Society...

  19. Effect of the ash Fall on the Human Health at Colima Volcano During 2005-2006.

    NASA Astrophysics Data System (ADS)

    Nieto, A.; Martin, A. L.; Fonseca, R.; Garcia, M.

    2007-05-01

    Colima Volcano in western Mexico had several small ash emitting eruptions during 2005-2006. In this time period we studied the impact of the ash fall on human health through field observations, interviews and health data processing. The volcano was most active in May-June 2005. Data from 15.000 medical records of the Colima and Jalisco State Health Departments show two main health problems in humans during this time: Conjunctivitis was detected in 1,933 people and respiratory disease in 12,630 people in an area of 1,841,283 km2 which was affected by small amounts of ash fall near the volcano in 2005. Ash emissions from Colima Volcano correlate well with increased affections. When emissions increased so did the frequency of these health problems in the population.

  20. 37th Annual Survey Report on State-Sponsored Student Financial Aid, 2005-2006 Academic Year

    ERIC Educational Resources Information Center

    National Association of State Student Grant and Aid Programs, 2006

    2006-01-01

    Each year, the National Association of State Student Grant and Aid Programs (NASSGAP) completes a survey regarding state-funded expenditures for postsecondary student financial aid. This report, the 37th annual survey, represents data from academic year 2005-06. Data highlights of the survey include: (1) In the 2005-2006 academic year, the states…

  1. Impact of the Boll Weevil Eradication Program in south Texas on predation of Lepidopteran eggs, 2005-2006.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Predation on eggs of the lepidopteran pests (Helicoverpa zea Boddie) and Spodoptera exigua (Hübner) in cotton was monitored before and during the first two seasons of the Boll Weevil Eradication Program in south Texas (2005-2006). Mortality of eggs was reduced after malathion sprays for boll weevil...

  2. Impact of the 2005-2006 drought on soil water content under a tall grass prairie at Fort Reno, Oklahoma.

    Technology Transfer Automated Retrieval System (TEKTRAN)

    This study examined changes in the seasonal pattern of soil water content under a tall grass prairie in central Oklahoma as a result of the 2005-2006 drought. The seasonal pattern of soil water content in the top 50 cm of the soil profile was minimally impacted by the drought, as this portion of the...

  3. Registration of fatal occupational injuries in Costa Rica, 2005-2006.

    PubMed

    Mora, Ana Maria; Mora-Mora, Maria Gabriela; Partanen, Timo; Wesseling, Catharina

    2011-01-01

    Data on fatal occupational injuries (FOIs) for Latin America are controversial. Costa Rican national rates are inconsistent with estimates extrapolated from other countries. We reviewed the files for all possible FOIs in Costa Rica for 2005-2006 at the National Insurance Institute and at the Center of Forensic Sciences by formality/informality of work, sex, age, economic activity, occupation, and cause of death. The national mortality rate was estimated at 9.5/100,000 person-years (342 deaths). The informal/formal rate ratio was 1.06. Men's rates were over 10 times higher than women's and increased with age. The highest rates were found for transport, storage, and communication (32.1/100,000 person-years), and, by occupation, for messengers and delivery men (91.4). Leading causes of death were traffic injuries and gunshots. Recalculated rates are probably underestimates. Data limitations include the absence of systematic identification and registration among informal sector workers and other groups such as children and farm workers. PMID:21905393

  4. Domestic violence in India: insights from the 2005-2006 national family health survey.

    PubMed

    Kimuna, Sitawa R; Djamba, Yanyi K; Ciciurkaite, Gabriele; Cherukuri, Suvarna

    2013-03-01

    This article assesses the prevalence and risk factors of domestic violence in India. The study uses the 2005-2006 India National Family Health Survey-III (NFHS-III) and focuses on the 69,484 ever-married women ages 15 to 49 from all regions, who were administered the domestic violence module. The results show that 31% of respondents experienced physical violence in the past 12 months before the survey; the corresponding figure for sexual violence was 8.3%. The multivariate logistic regression results show key determinants of physical and sexual violence. Some of the most salient findings are that urban residence, household wealth, affiliation with Christian religious denominations, wife's age at marriage and education are associated with lower risk of physical and sexual violence. In contrast, being employed and being the wife of a man who drank alcohol increased the odds of experiencing both physical and sexual violence. Moreover, respondents who believed that wife-beating was justified under certain circumstances were more likely to experience domestic violence. These results and significant regional differences observed in this study suggest that gender role conditioning and cultural norms both contribute to domestic violence. Interventions, therefore, need to go beyond the institutional and legal levels to include cultural capital, which addresses partner and relationship issues. PMID:22935947

  5. Genetic characterization of dengue virus type 1 isolated in Brunei in 2005-2006.

    PubMed

    Osman, Osmali; Fong, Mun Yik; Sekaran, Shamala Devi

    2009-03-01

    The full-length genomes of two DENV-1 viruses isolated during the 2005-2006 dengue incidents in Brunei were sequenced. Twenty five primer sets were designed to amplify contiguous overlapping fragments of approximately 500-600 base pairs spanning the entire sequence of the genome. The amplified PCR products were sent to a commercial laboratory for sequencing and the nucleotides and the deduced amino acids were determined. Sequence analysis of the envelope gene at the nucleotide and amino acid levels between the two isolates showed 92 and 96 % identity, respectively. Comparison of the envelope gene sequences with 68 other DENV-1 viruses of known genotypes placed the two isolates into two different genotypic groups. Isolate DS06/210505 belongs to genotype V together with some of the recent isolates from India (2003) and older isolates from Singapore (1990) and Burma (1976), while isolate DS212/110306 was clustered in genotype IV with the prototype Nauru strain (1974) and with some of the recent isolates from Indonesia (2004) and the Philippines (2002, 2001). In the full-length genome analysis at the nucleotide level, isolate DS06/210505 showed 94 % identity to the French Guyana strain (1989) in genotype V while isolate DS212/110306 had 96 % identity to the Nauru Island strain (1974) in genotype IV. This work constitutes the first complete genetic characterization of not only Brunei DENV-1 virus isolates, but also the first strain from Borneo Island. This study was the first to report the isolation of dengue virus in the country. PMID:19218214

  6. Monitoring of land subsidence and ground fissures in Xian, China 2005-2006: Mapped by sar Interferometry

    USGS Publications Warehouse

    Zhao, C.Y.; Zhang, Q.; Ding, X.-L.; Lu, Zhiming; Yang, C.S.; Qi, X.M.

    2009-01-01

    The City of Xian, China, has been experiencing significant land subsidence and ground fissure activities since 1960s, which have brought various severe geohazards including damages to buildings, bridges and other facilities. Monitoring of land subsidence and ground fissure activities can provide useful information for assessing the extent of, and mitigating such geohazards. In order to achieve robust Synthetic Aperture Radar Interferometry (InSAR) results, six interferometric pairs of Envisat ASAR data covering 2005-2006 are collected to analyze the InSAR processing errors firstly, such as temporal and spatial decorrelation error, external DEM error, atmospheric error and unwrapping error. Then the annual subsidence rate during 2005-2006 is calculated by weighted averaging two pairs of D-InSAR results with similar time spanning. Lastly, GPS measurements are applied to calibrate the InSAR results and centimeter precision is achieved. As for the ground fissure monitoring, five InSAR cross-sections are designed to demonstrate the relative subsidence difference across ground fissures. In conclusion, the final InSAR subsidence map during 2005-2006 shows four large subsidence zones in Xian hi-tech zones in western, eastern and southern suburbs of Xian City, among which two subsidence cones are newly detected and two ground fissures are deduced to be extended westward in Yuhuazhai subsidence cone. This study shows that the land subsidence and ground fissures are highly correlated spatially and temporally and both are correlated with hi-tech zone construction in Xian during the year of 2005-2006. ?? Springer-Verlag 2008.

  7. Commissioning

    SciTech Connect

    Huta, L.G.

    1995-12-01

    Building managers often find that HVAC, lighting and other systems in new buildings need adjustments and modifications. The owner, architect and contractor may mistakenly assume that all of a building`s systems--architectural, mechanical, control and electrical--function according to the design intent. Thus, energy managers can optimize their building`s performance through commissioning, a process that looks for and corrects the defects in a building` operating system or design, immediately before and after it is occupied (following construction or renovation).

  8. Breastfeeding in England: time trends 2005-2006 to 2012-2013 and inequalities by area profile.

    PubMed

    Oakley, Laura L; Kurinczuk, Jennifer J; Renfrew, Mary J; Quigley, Maria A

    2016-07-01

    Breastfeeding rates in England have risen steadily since the 1970s, but rates remain low and little is known about area-based trends. We report an ecological analysis of time trends in area breastfeeding rates in England using annual data on breastfeeding initiation (2005-2006 to 2012-2013) and any breastfeeding at 6-8 weeks (2008-2009 to 2012-2013) for 151 primary care trusts (PCTs). Overall, breastfeeding initiation rose from 65.5% in 2005-2006 to 72.4% in 2012-2013 (average annual absolute increase 0.9%). There was a statistically significantly higher (interaction P < 0.001) annual increase in initiation in PCTs in the most deprived (1.2%) compared with the least deprived tertile (0.7%), and in PCTs with low baseline breastfeeding initiation (2005-2006; 1.4%) compared with high baseline initiation (0.6%). Similar trends were observed when PCTs were stratified by the proportion of teenage mothers and maternal smoking, but not when stratified by ethnicity. Although breastfeeding prevalence at 6-8 weeks also increased significantly over the observed time period (41.2% in 2008-2009, 43.7% in 2012-2013; annual increase 0.7%), there was no difference in the average increase by deprivation profile, ethnicity, teenage mothers and maternal smoking. However, PCTs with low baseline prevalence in 2008-2009 saw a significantly larger annual increase (0.8%) compared with PCTs with high baseline prevalence (0.07%). In conclusion, breastfeeding initiation and prevalence have seen higher increases in areas with low initial breastfeeding, and for initiation, more disadvantaged areas. Although these results suggest that inequalities in breastfeeding have narrowed, rates have plateaued since 2010-2011. Sustained efforts are needed to address breastfeeding inequalities. PMID:25422164

  9. [The benefit provided by new medicinal products in 2005-2006--the viewpoint of the French National Authority for Health].

    PubMed

    Bouvenot, Gilles

    2007-01-01

    The French National Authority for Health (HAS) assesses the actual benefit provided by medicinal products within a defined legal framework. It provides an independent scientific opinion. It aims to ensure equity, taking into account a variety of points of view as a result of close collaboration with health professionals. In 2005-2006, the mean time to process requests by the Transparency Committee was 100 days (median 77 days) and faster than in previous years. Over 30% of new medicinal products undergoing a first assessment or an assessment for an extension to indications were deemed to provide added value. This added value was marked for 25% of the products (i.e. an improvement in actual benefit ("ASMR") of I to III). Many of these products were orphan drugs and/or biotechnology products. PMID:18206101

  10. Evaluation of Salmon Spawning Below Bonneville Dam, 2005-2006 Annual Report.

    SciTech Connect

    Arntzen, Evan; Mueller, Robert; Murray, Christopher

    2007-03-01

    Since FY 2000, scientists at Pacific Northwest National Laboratory (PNNL) have conducted research to assess the extent of spawning by chum salmon (Oncorhynchus keta) and fall Chinook salmon (O. tshawytscha) in the lower mainstem Columbia River. Their work supports a larger project funded by the Bonneville Power Administration (BPA) aimed at characterizing the physical habitat used by mainstem fall Chinook and chum salmon populations. Multiple collaborators in addition to PNNL are involved in the BPA project--counterparts include the Washington Department of Fish and Wildlife (WDFW), U.S. Fish and Wildlife Service (USFWS), Pacific States Marine Fisheries Commission (PSMFC), U.S. Geological Survey (USGS), and Oregon Department of Fish and Wildlife (ODFW). Data resulting from the individual tasks each agency conducts are providing a sound scientific basis for developing strategies to operate the Federal Columbia River Power System (FCRPS) in ways that will effectively protect and enhance the chum and tule fall Chinook salmon populations--both listed as threatened under the Endangered Species Act (ESA). Fall Chinook salmon, thought to originate from Bonneville Hatchery, were first noted to be spawning downstream of Bonneville Dam by WDFW biologists in 1993. Known spawning areas include gravel beds on the Washington side of the river near Hamilton Creek and near Ives Island. Limited surveys of spawning ground were conducted in the area around Ives and Pierce islands from 1994 through 1997. Based on those surveys, it is believed that fall Chinook salmon are spawning successfully in this area. The size of this population from 1994 to 1996 was estimated at 1800 to 5200 fish. Chum salmon also have been documented spawning downstream of Bonneville Dam. Chum salmon were listed as threatened under the ESA in March 1999. At present there is a need to determine the number of fall Chinook and chum salmon spawning downstream of Bonneville Dam, the characteristics of their spawning

  11. Closing Doors of Opportunity? Trends in Enrollment, College Costs, and Direct Grant Aid at Community Colleges in the United States, 2000-2001 to 2005-2006

    ERIC Educational Resources Information Center

    Kennamer, Michael A.; Katsinas, Stephen G.; Hardy, David E.; Roessler, Billy

    2010-01-01

    This study had two major purposes. The first purpose was to compare federal, state, and institutional direct grant aid, unmet needs, and headcount in 2000-2001 and 2005-2006. The second was to assess if any changes found related to the presence or absence of two key factors identified by experts as important to understanding the community college…

  12. The active tropical cyclone season of 2005 2006 over Northwest Australia: Operational model performance and high resolution case studies

    NASA Astrophysics Data System (ADS)

    Buckley, B. W.; Leslie, L. M.; Leplastrier, M.; Qi, L.

    2007-08-01

    There are three main aims of this study. First, the main features of the active 2005 2006 Australian region tropical cyclone (TC) season are summarized, with particular emphasis on the northwest Australian region. Second, an assessment is made of the skill of the available operational global and regional numerical weather prediction (NWP) models for three of the most significant TCs (TCs Clare, Glenda and Hubert), each of which made landfall on the northwest coast of Australia. Third, high-resolution numerical modelling simulations of these same three TCs are described in detail. The numerical weather prediction (NWP) model used here was developed at the University of Oklahoma, and in this study it utilises initial and boundary conditions obtained from archived analyses and forecasts provided by the Australian Bureau of Meteorology, as well as a 4D-Var data assimilation scheme to ingest all available satellite data. The high-resolution numerical model is multiply two-way nested, with the innermost domain having a resolution of 5 km. It was found that unlike the operational models, which were restricted by relatively low resolution and less data, the high resolution model was able to capture most of the major features of all three TC lifecycles including development from initial tropical depressions, intensification, and their tracks, landfall, and associated rainfall and wind fields.

  13. Mammography use for breast cancer screening in Portugal: results from the 2005/2006 National Health Survey

    PubMed Central

    Dourado, Fernanda; Carreira, Helena

    2013-01-01

    Background: Understanding the patterns of mammography use is essential to promote the participation in breast cancer screening. Objectives: To describe the patterns of screening mammography use in Portugal. Methods: As part of the fourth National Health Survey (2005/2006), 3045 women were evaluated in face-to-face interviews. The previous use of mammography for screening was classified as never or ever, and the latter was further grouped according to the time elapsed since the latest mammography. Having undergone the latest mammography >2 years before was considered underuse. We assessed the determinants of never having been screened by mammography and, among those who had been tested, the determinants of mammography underuse, through age- and education-adjusted odds ratios (ORs), with 95% confidence intervals (95% CIs). Results: Among women aged 45–49 and 50–69 years, 86.3% and 88.0%, respectively, underwent a screening mammography before, and most of them were tested in the previous 2 years. The lowest risk of never having been screened was in Norte (OR = 0.41, 95% CI: 0.21–0.80) and the highest in Açores (OR = 4.04, 95% CI: 2.37–6.92), in comparison with Centro (the region with organized screening for a longer time). Participants with <4 years of formal education were more likely to have never been screened than the more educated (OR = 4.27, 95% CI: 1.67–10.89). Women with private health insurance (OR = 0.16, 95% CI: 0.04–0.65), as well as those who had undergone cervical cytology screening before (OR = 0.50, 95% CI: 0.30–0.85), had a lower risk of underuse. Conclusions: This study provides useful information to improve the allocation of resources to breast cancer screening. PMID:22874736

  14. Prevalence of serotype 19A Streptococcus pneumoniae among isolates from U.S. children in 2005-2006 and activity of faropenem.

    PubMed

    Critchley, Ian A; Jacobs, Michael R; Brown, Steven D; Traczewski, Maria M; Tillotson, Glenn S; Janjic, Nebojsa

    2008-07-01

    Of 393 isolates of Streptococcus pneumoniae from U.S. children collected in 2005-2006, nonvaccine serotypes accounted for 89.1%, with serotype 19A the most prevalent, representing 30.5% of all isolates. The MIC(90) of faropenem against serotype 19A isolates was 1 mug/ml, compared to > or =8 microg/ml against amoxicillin/clavulanate, cefdinir, cefuroxime axetil, and azithromycin. PMID:18443117

  15. Prevalence of Serotype 19A Streptococcus pneumoniae among Isolates from U.S. Children in 2005-2006 and Activity of Faropenem▿

    PubMed Central

    Critchley, Ian A.; Jacobs, Michael R.; Brown, Steven D.; Traczewski, Maria M.; Tillotson, Glenn S.; Janjic, Nebojsa

    2008-01-01

    Of 393 isolates of Streptococcus pneumoniae from U.S. children collected in 2005-2006, nonvaccine serotypes accounted for 89.1%, with serotype 19A the most prevalent, representing 30.5% of all isolates. The MIC90 of faropenem against serotype 19A isolates was 1 μg/ml, compared to ≥8 μg/ml against amoxicillin/clavulanate, cefdinir, cefuroxime axetil, and azithromycin. PMID:18443117

  16. Paving the seafloor: Volcanic emplacement processes during the 2005-2006 eruptions at the fast spreading East Pacific Rise, 9°50‧N

    NASA Astrophysics Data System (ADS)

    Fundis, A. T.; Soule, S. A.; Fornari, D. J.; Perfit, M. R.

    2010-08-01

    The 2005-2006 eruptions near 9°50'N at the East Pacific Rise (EPR) marked the first observed repeat eruption at a mid-ocean ridge and provided a unique opportunity to deduce the emplacement dynamics of submarine lava flows. Since these new flows were documented in April 2006, a total of 40 deep-towed imaging surveys have been conducted with the Woods Hole Oceanographic Institution's (WHOI) TowCam system. More than 60,000 digital color images and high-resolution bathymetric profiles of the 2005-2006 flows from the TowCam surveys were analyzed for lava flow morphology and for the presence of kipukas, collapse features, faults and fissures. We use these data to quantify the spatial distributions of lava flow surface morphologies and to investigate how they relate to the physical characteristics of the ridge crest, such as seafloor slope, and inferred dynamics of flow emplacement. We conclude that lava effusion rate was the dominant factor controlling the observed morphological variations in the 2005-2006 flows. We also show that effusion rates were higher than in previously studied eruptions at this site and varied systematically along the length of the eruptive fissure. This is the first well-documented study in which variations in seafloor lava morphology can be directly related to a well documented ridge-crest eruption where effusion rate varied significantly.

  17. Timing, Distribution, and Character of Tephra Fall from the 2005-2006 Eruption of Augustine Volcano, Alaska

    NASA Astrophysics Data System (ADS)

    Wallace, K. L.; Neal, C.; McGimsey, G.

    2006-12-01

    The 2005-2006 eruption of Augustine Volcano produced tephra-fall deposits during four eruptive phases. The island setting, deposition of thin, fine-grained fall deposits onto the snowpack, and subsequent reworking by high winds and surface-water flow has removed much of the original proximal fall record. During the late precursory phase (December 2005), small phreatic explosions produced very light, localized tephra fall. Tephra from one such event is composed of altered and fresh, possibly juvenile, glass shards. The greatest volume of tephra fall was produced during the explosive phase (January 11 - 28) when 13 discrete explosive events generated plumes between 3 -14 km ASL during a period of dome building and collapse. Associated strong seismicity lasted 1-11 min (avg 4 min), closely matching the duration of plume generation followed by detachment from the vent and distribution by local winds. On January 11, explosions generated two plumes to ~9 km ASL and deposited trace amounts of ash on communities surrounding Lake Iliamna W and NW of Augustine. Tephra from this event are not well preserved and were likely small in volume, but proximal and distal samples collected during the eruption are composed mainly of older dense dome fragments and crystals with little to no juvenile material. On January 13 and 14, six discrete explosions produced plumes to 9 - 11 km ASL that dispersed to the N-NE and deposited < 1mm of ash on Homer, Seldovia, Nanwelek and Port Graham. Coarse proximal fall deposits are composed mainly of olive- green, scoriaceous, low-silica andesite; subordinate black, dense, porphyritic low-silica andesite; white, variably vesicular high-silica andesite; and accidental lithic fragments. During this time, low-silica andesite dome extrusion was occurring. An explosion on January 17 produced a plume to ~14 km ASL that dispersed to the W-NW and deposited 1 mm of ash on communities surrounding Lake Iliamna. Coarse proximal fall deposits contain the same

  18. Kelt Reconditioning: A Research Project to Enhance Iteroparity in Columbia Basin Steelhead (Oncorhynchus mykiss), 2005-2006 Annual Report.

    SciTech Connect

    Branstetter, Ryan; Whiteaker, John; Hatch, Douglas R.

    2006-12-01

    Iteroparity, the ability to repeat spawn, is a natural life history strategy that is expressed by some species from the family Salmonidae. Estimated rates of repeat spawning for post-development Columbia River steelhead Oncorhynchus mykiss populations range from 1.6 to 17%. It is expected that currently observed iteroparity rates for wild steelhead in the Basin are severely depressed due to development and operation of the hydropower system and various additional anthropogenic factors. Increasing the current expression of repeat spawning rates using fish culturing methods could be a viable technique to assist the recovery of depressed steelhead populations, and could help reestablish this naturally occurring life history trait. Reconditioning is the process of culturing post-spawned fish (kelts) in a captive environment until they are able to reinitiate feeding, growth, and redevelop mature gonads. Reconditioning techniques were initially developed for Atlantic salmon Salmo salar and sea-trout S. trutta. The recent Endangered Species Act listing of many Columbia River Basin steelhead populations has prompted interest in developing reconditioning methods for wild steelhead populations within the Basin. To test kelt steelhead reconditioning as a potential recovery tool, wild emigrating steelhead kelts were placed into one of four study groups (in river release, direct capture and transport, short-term reconditioning, or long-term reconditioning). Steelhead kelts from the Yakima River were collected at the Chandler Juvenile Monitoring Facility (CJMF, located on the Yakima River at river kilometer 75.6) from 7 March to 8 June 2006. In total, 348 kelts were collected for reconditioning at Prosser Hatchery. Captive specimens represented 17.0% (348 of 2,002) of the entire 2005-2006 Yakima River wild steelhead population, based on fish ladder counts at Prosser Dam. Steelhead kelts were reconditioned in 20-foot circular tanks, and fed freeze-dried krill initially (first 2

  19. Food sources of arachidonic acid (PFA 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Cancer.gov

    Food sources of arachidonic acid (PFA 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  20. Food sources of alpha-linolenic acid (PFA 18:3), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Cancer.gov

    Food sources of alpha-linolenic acid (PFA 18:3), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  1. Food sources of total omega 6 fatty acids (18:2 + 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Cancer.gov

    Food sources of total omega 6 fatty acids (18:2 + 20:4), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  2. Changes in mean intake of fatty acids and intake of saturated and trans fats from potatoes: NHANES 2005-2006, 2007-2008, and 2009-2010.

    PubMed

    Storey, Maureen L; Anderson, Patricia A

    2015-05-01

    Studies have shown that higher than usual intakes of trans fatty acids (TFAs) have adverse effects on blood lipids. Because of this, in 2006 the US FDA mandated labeling of TFAs on food packages. The food and restaurant industries, including the potato industry, reformulated their foods to reduce or eliminate partially hydrogenated vegetable oils and TFAs. Before mandatory labeling, grain-based desserts, yeast breads, and French-fried potatoes (FFPs) were the top sources of TFAs in the food supply; by 2007, potato food manufacturers and quick-service restaurants had reduced or eliminated TFAs without increasing saturated fatty acids (SFAs). FFPs are no longer a source of TFAs in the food supply. This study examined energy and fatty acid intake among children aged 6-11 y, adolescents aged 12-18 y, and adults aged ≥19 y across 3 time periods by using data from the NHANES 2005-2006, 2007-2008, and 2009-2010. On average, intakes of total energy, total fat, SFAs, and monounsaturated fatty acids (MUFAs) decreased significantly between 2005-2006 and 2009-2010 among children and adolescents; however, the intake of polyunsaturated fatty acids (PUFAs) did not change. Among adults, intakes of total fat, SFAs, and MUFAs decreased; however, total energy and PUFA intake did not change. On the day of the 2009-2010 survey, ∼13% of children and 10% of adolescents reported consuming fried FFPs, whereas <7% of adults reported consumption of fried FFPs. Intakes of SFAs and TFAs from fried FFPs decreased significantly between 2005-2006 and 2009-2010 among children, adolescents, and adults. This study confirms that intake of TFAs from FFPs is trivial. PMID:25979511

  3. National and Regional Assessment of Antimicrobial Resistance among Community-Acquired Respiratory Tract Pathogens Identified in a 2005-2006 U.S. Faropenem Surveillance Study▿

    PubMed Central

    Critchley, Ian A.; Brown, Steven D.; Traczewski, Maria M.; Tillotson, Glenn S.; Janjic, Nebojsa

    2007-01-01

    Surveillance studies conducted in the United States over the last decade have revealed increasing resistance among community-acquired respiratory pathogens, especially Streptococcus pneumoniae, that may limit future options for empirical therapy. The objective of this study was to assess the scope and magnitude of the problem at the national and regional levels during the 2005-2006 respiratory season (the season when community-acquired respiratory pathogens are prevalent) in the United States. Also, since faropenem is an oral penem being developed for the treatment of community-acquired respiratory tract infections, another study objective was to provide baseline data to benchmark changes in the susceptibility of U.S. respiratory pathogens to the drug in the future. The in vitro activities of faropenem and other agents were determined against 1,543 S. pneumoniae isolates, 978 Haemophilus influenzae isolates, and 489 Moraxella catarrhalis isolates collected from 104 U.S. laboratories across six geographic regions during the 2005-2006 respiratory season. Among S. pneumoniae isolates, the rates of resistance to penicillin, amoxicillin-clavulanate, and cefdinir were 16, 6.4, and 19.2%, respectively. The least effective agents were trimethoprim-sulfamethoxazole (SXT) and azithromycin, with resistance rates of 23.5 and 34%, respectively. Penicillin resistance rates for S. pneumoniae varied by region (from 8.7 to 22.5%), as did multidrug resistance rates for S. pneumoniae (from 8.8 to 24.9%). Resistance to β-lactams, azithromycin, and SXT was higher among S. pneumoniae isolates from children than those from adults. β-Lactamase production rates among H. influenzae and M. catarrhalis isolates were 27.4 and 91.6%, respectively. Faropenem MICs at which 90% of isolates are inhibited were 0.5 μg/ml for S. pneumoniae, 1 μg/ml for H. influenzae, and 0.5 μg/ml for M. catarrhalis, suggesting that faropenem shows promise as a treatment option for respiratory infections caused

  4. National and regional assessment of antimicrobial resistance among community-acquired respiratory tract pathogens identified in a 2005-2006 U.S. Faropenem surveillance study.

    PubMed

    Critchley, Ian A; Brown, Steven D; Traczewski, Maria M; Tillotson, Glenn S; Janjic, Nebojsa

    2007-12-01

    Surveillance studies conducted in the United States over the last decade have revealed increasing resistance among community-acquired respiratory pathogens, especially Streptococcus pneumoniae, that may limit future options for empirical therapy. The objective of this study was to assess the scope and magnitude of the problem at the national and regional levels during the 2005-2006 respiratory season (the season when community-acquired respiratory pathogens are prevalent) in the United States. Also, since faropenem is an oral penem being developed for the treatment of community-acquired respiratory tract infections, another study objective was to provide baseline data to benchmark changes in the susceptibility of U.S. respiratory pathogens to the drug in the future. The in vitro activities of faropenem and other agents were determined against 1,543 S. pneumoniae isolates, 978 Haemophilus influenzae isolates, and 489 Moraxella catarrhalis isolates collected from 104 U.S. laboratories across six geographic regions during the 2005-2006 respiratory season. Among S. pneumoniae isolates, the rates of resistance to penicillin, amoxicillin-clavulanate, and cefdinir were 16, 6.4, and 19.2%, respectively. The least effective agents were trimethoprim-sulfamethoxazole (SXT) and azithromycin, with resistance rates of 23.5 and 34%, respectively. Penicillin resistance rates for S. pneumoniae varied by region (from 8.7 to 22.5%), as did multidrug resistance rates for S. pneumoniae (from 8.8 to 24.9%). Resistance to beta-lactams, azithromycin, and SXT was higher among S. pneumoniae isolates from children than those from adults. beta-Lactamase production rates among H. influenzae and M. catarrhalis isolates were 27.4 and 91.6%, respectively. Faropenem MICs at which 90% of isolates are inhibited were 0.5 mug/ml for S. pneumoniae, 1 mug/ml for H. influenzae, and 0.5 mug/ml for M. catarrhalis, suggesting that faropenem shows promise as a treatment option for respiratory infections

  5. Enhanced Collection of Laboratory Data in HIV Surveillance Among 5 States with Confidential Name-based HIV Infection Reporting, 2005-2006

    PubMed Central

    Gray, Kristen Mahle; Kajese, Tebitha; Crandell-Alden, Erin; Anderson, Bridget J; Wendell, Debbie; Crutchfield, Allison; Jackson, Terry; Hall, H. Irene

    2012-01-01

    Laboratory data reported through HIV surveillance can provide information about disease severity and linkage to care; however these measures are only as accurate as the quality and completeness of data reported. Using data from five states that implemented enhanced collection of laboratory data in HIV surveillance from 2005-2006, we determined completeness of reporting, stage of disease at diagnosis, the most common opportunistic illnesses (OI) at diagnosis, and linkage to medical care. Methods to enhance laboratory reporting included increasing active surveillance efforts, identifying laboratories not reporting to HIV surveillance, increasing electronic reporting, and using laboratory results from auxiliary databases. Of 3,065 persons ≥13 years of age diagnosed with HIV, 35.5% were diagnosed with stage 3 (AIDS) and 37.7% progressed to stage 3 within 12-months after diagnosis. Overall, 78.5% were linked to care within 3 months; however, a higher proportion of persons with ≥1 CD4 or viral load test was found among whites compared with blacks/African Americans (82.1% vs 73.6%, p<0.001). Few (12.3%) had an OI within 3 months of diagnosis. The completeness of laboratory data collected through surveillance was improved with enhanced reporting and provided a more accurate picture of stage of disease and gaps in linkage to care. Additional interventions are needed to meet the goals of the National HIV/AIDS Strategy on linkage to care and the reduction of HIV-related disparities. PMID:23056161

  6. CEAS-ASC highlights 2006

    NASA Astrophysics Data System (ADS)

    Caro, Stéphane

    2007-07-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on a European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on some highlights of aeroacoustics research in Europe in 2006, compiled from information provided to the ASC of the CEAS. During 2006, numerous research programmes were funded by the European Union. Some of the contributions submitted to the editor summarize selected findings from these programmes, while other articles cover issues supported by national associations. Furthermore, a concise summary of the workshop on "Aeroacoustics of Jet Noise" held in Dublin in September is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

  7. Recruiting Trends, 2005-2006

    ERIC Educational Resources Information Center

    Collegiate Employment Research Institute (NJ3), 2006

    2006-01-01

    Almost 900 employers responded to this year's "Recruiting Trends" survey, the largest response in the history of this project. Hiring of college graduates is expected to increase by single digits minimally, or double digits if certain geographic sectors are excluded (between 6% and 14%). This growth follows a robust 20% increase in hiring reported…

  8. Principals' Salaries, 2005-2006

    ERIC Educational Resources Information Center

    Williams, Alicia R.

    2006-01-01

    How do salaries of elementary and middle school principals compare with those of other administrators and classroom teachers? Are increases in salaries of principals keeping pace with increases in salaries of classroom teachers? How have principals' salaries fared over the years when the cost of living is taken into account? To provide answers to…

  9. Indoor mildew odour in old housing was associated with adult allergic symptoms, asthma, chronic bronchitis, vision, sleep and self-rated health: USA NHANES, 2005-2006.

    PubMed

    Shiue, Ivy

    2015-09-01

    A recent systematic review and meta-analysis has shown the effect of indoor mildew odour on allergic rhinitis risk, but its relation to other common chronic health outcomes in adults has not been investigated. Therefore, it was aimed to examine the relationship of indoor mildew odour and common health outcomes in adults in a national and population-based setting. Data was retrieved from the United States National Health and Nutrition Examination Surveys, 2005-2006, including the available information on demographics, housing characteristics, self-reported health conditions and urinary concentrations of environmental chemicals. T test, chi-squared test and survey-weighted logistic regression modelling were performed. Of all American adults (n = 4979), 744 (15.1%) reported indoor mildew odour or musty smell in their households. People who reported indoor mildew odour or musty smell also reported poorer self-rated health, sleep complaints, chronic bronchitis, asthma attack, itchy rash, sneezing and poor vision. In addition, people who reported indoor mildew odour or musty smell also tended to reside in older housing that were built 20 years earlier. However, there were no significant statistical associations found between indoor mildew odour or musty smell and urinary concentrations of environmental chemicals, which was also found to be associated with old housing. People who lived in older housing with indoor mildew odour or musty smell tended to have chronic health problems. To protect occupants in old housing from chronic illnesses associated with indoor mildew odour, elimination of the odour sources should be explored in future research and therefore public health and housing programs. Graphical abstract Pathway from old housing to musty smell, environmental chemicals and then health outcomes. PMID:25971810

  10. People with diabetes, respiratory, liver or mental disorders, higher urinary antimony, bisphenol A, or pesticides had higher food insecurity: USA NHANES, 2005-2006.

    PubMed

    Shiue, Ivy

    2016-01-01

    This study was aimed to examine the prevalence of food insecurity and what social, health, and environmental characteristics could constitute such situation in a national and population-based setting. Data was retrieved from the National Health and Nutrition Examination Survey, 2005-2006. Information on demographics, lifestyle factors, self-reported ever medical conditions in the past and self-reported food security conditions in the last 12 months calculated on the household level was obtained by household interview. Bloods and urines (subsample) were collected at the interview as well. Only adults aged 20 years and above (n = 4979) were included for statistical analysis in the present study. Chi-square test, t test, and survey-weighted logistic regression modeling were performed. Three thousand eight hundred thirty-four (77.9%) people were with full food security, 466 (9.5%) people were with marginal food security and 624 (12.7%) people were with low or very low food security. Being younger, having higher ratios of family income to poverty thresholds (due to low level of education or lack of financial support), having prior asthma, arthritis, chronic bronchitis, depression, diabetes, eczema, emphysema or liver problems, having higher levels of serum cotinine, urinary antimony, bisphenol A, pesticides, or having lower levels of urinary Benzophenone-3 were associated with food insecurity. In addition to socioeconomic and smoking conditions, evidence on people with several prior health conditions and being exposed to environmental chemicals and food insecurity is further provided. Future social, health and environmental policy, and programs protecting people from food insecurity by considering both health and environmental factors mentioned above would be suggested. PMID:26517997

  11. IgE antibodies and urinary trimethylarsine oxide accounted for 1-7% population attributable risks for eczema in adults: USA NHANES 2005-2006.

    PubMed

    Shiue, Ivy

    2015-12-01

    Population attributable risks from serum IgE and dust miteallergen concentrations and environmental chemicals for eczema are unclear. Therefore, it was aimed to examine serum IgE and allergen concentrations and environmental chemicals for eczema in adults and to calculate population attributable risks in a national and population-based setting. Data retrieved from the National Health and Nutrition Examination Survey, 2005-2006, was analyzed. Information on demographics and self-reported ever eczema was obtained by household interview. Bloods and urines (sub-sample) were also collected during the interview. Adults aged 20-85 were included. Statistical analyses were using chi-square test, t test, survey-weighted logistic regression modeling, and population attributable risk (PAR) estimation. Of all the included American adults (n = 4979), 310 (6.2%) reported ever eczema. Moreover, more eczema cases were observed in female adults but fewer cases in people born in Mexico. There were no significant associations observed between commonly known biomarkers (including vitamin D) and eczema or between dust mite allergens and eczema. Serum D. Farinae (PAR 1.0%), D. Pteronyssinus (PAR 1.1%), cat (PAR 1.8%), dog (PAR 1.6%), and muse (PAR 3.2%) IgE antibodies were associated with eczema. Adults with ever eczema were found to have higher levels of urinary trimethylarsine oxide concentrations (PAR 7.0%) but not other speciated arsenic concentrations. There were no clear associations between other environmental chemicals including heavy metals, phthalates, phenols, parabens, pesticides, nitrate, perchlorate, polycyclic hydrocarbons and eczema as well. Elimination of environmental risks might help delay or stop eczema up to 7% in the adult population. PMID:26233738

  12. Awareness of Federal Dietary Guidance in persons aged 16 years and older: results from the National Health and Nutrition Examination Survey 2005-2006.

    PubMed

    Wright, Jacqueline D; Wang, Chia-Yih

    2011-02-01

    The National Health and Nutrition Examination Survey 2005-2006 included questions on awareness of the Dietary Guidelines for Americans (DGA), the Food Guide Pyramid, and the 5 A Day for Better Health Program. Prevalence of awareness of federal dietary guidance was estimated and differences were tested across demographic traits, health characteristics, and diet-related attitudes and behavior. The continuous National Health and Nutrition Examination Survey uses a nationally representative cross-sectional sample design. The analytic sample consisted of 5,499 persons aged 16 years and older with complete data. Among persons aged 16 years and older, 83.8% had heard of at least one of the initiatives: 49.2% had heard of the DGA, 80.6% had heard of the Food Guide Pyramid, and 51.2% had heard of the 5 A Day program. There was a linear trend of decreasing awareness of at least one of the guidance efforts with increasing age. Differences by sex, race/ethnicity, education, and income were also observed. Differences by body mass index were not statistically significant; however, significant differences were seen with fatalistic beliefs about body weight. Differences by smoking, self-assessed diet quality, and eating out frequency were not statistically significant after adjustment for sex, age, race/ethnicity, education, and income. These results may be useful in promotion of the upcoming edition of the DGA and to suggest population groups that may benefit from strengthened and more innovative education efforts at the public health program level and at the clinic level. PMID:21272706

  13. Geochemistry of the 2005-2006 East Pacific Rise Eruption: Chemical Changes and Possible Petrogenetic Relationships to the 1991-1992 Eruption

    NASA Astrophysics Data System (ADS)

    Trump, B. E.; Perfit, M. R.; Ridley, W. I.; Soule, S. A.; Fornari, D. J.

    2008-12-01

    The first opportunity to study a well-documented temporal sequence of eruptions at one mid-ocean ridge (MOR) locality presented itself when a second eruption was discovered in 2006 on the East Pacific Rise (EPR) around 9 °50 'N, 15 years after an eruption was witnessed in 1991-1992. Major and trace element analyses of glass samples from the 2005-2006 eruption indicate that the flows are largely aphyric, relatively homogeneous N-type MORB but exhibit some geochemical variability outside of analytical uncertainties. Relative to the more than 1200 basalts that have been analyzed from this section of the Integrated Study Site (ISS), samples from the 2005-06 eruption are moderately evolved (7.5 to 8.3 weight percent MgO), and are more evolved than the basalts erupted in 1991-92 (8.3 to 8.9 weight percent MgO). However, both the 2005- 06 and 1991-92 eruptions appear to have originated from the same incompatible element-depleted mantle source. Modeling of the observed chemical variability suggests the 2005-06 flows could be related to the most primitive 1991-92 lava by up to ~10 percent low-pressure fractional crystallization. The compositions of the new flows fall along a liquid line of descent predicted by the crystallization of olivine and plagioclase in ratios that range, respectively, from approximately 6:1 to 1:2, and at crystallization temperatures that range from approximately 1200 °C to 1140 °C. Some gabbroic crystal clots enclosed in the young lavas support this model but others suggest complex crystal-melt interactions in the subaxial magma chamber. Additionally, chemical and spatial data from the 2005-06 eruption may indicate chemical differentiation of the lava along axis during the eruptive process. Although the data are consistent with small amounts of crystal fractionation of the 1991-92 parent over the past 15 years, it is possible the elemental trends were created by mixing between the parental melt and a more evolved magma from another part of the

  14. Decommissioning of the nuclear licensed facilities at the Fontenay aux Roses CEA center

    SciTech Connect

    Jeanjacques, Michel; Piketty, Laurence; Letuhaire, Nathalie; Mandard, Lionel; Meden, Igor; Estivie, David; Boissonneau, Jean Francois; Fouquereau, Alain; Pichereau, Eric; Binet, Cedric

    2007-07-01

    Available in abstract form only. Full text of publication follows: The French Atomic Energy Commission (CEA) center at Fontenay aux Roses (CEN-FAR) is the Commission's oldest center is located in the southern suburbs of Paris. It was opened on 26 March 1946 to host the first French nuclear reactor ZOE that went critical on 12 December 1946. The first laboratories were installed in existing buildings on the site. (authors)

  15. An Information Building on Radioactivity and Nuclear Energy for the French CEA Cadarache Research Center - 13492

    SciTech Connect

    Brunel, Guy; Denis, Dominique; Boulet, Alain

    2013-07-01

    The CEA Cadarache research center is one of the 10 research centers of the French Alternative Energies and Atomic Energy Commission (CEA). Distributed throughout various research platforms, it focuses on nuclear fission, nuclear fusion, new energy technologies (hydrogen, solar, biomass) and fundamental research in the field of vegetal biology. It is the most important technological research and development centers for energy in Europe. Considering the sensitive nature of nuclear activities, the questions surrounding the issue of radioactive waste, the nuclear energy and the social, economic and environmental concerns for present and future generations, the French Government asked nuclear actors to open communication and to give all the information asked by the Local Information Commission (CLI) and the public [1]. In this context, the CEA Cadarache has decided to better show and explain its expertise and experience in the area of nuclear energy and nuclear power plant design, and to make it available to stakeholders and to the public. CEA Cadarache receives each year more than 9000 visitors. To complete technical visits of the research facilities and laboratories, a scientific cultural center has been built in 2011 to inform the public on CEA Cadarache research activities and to facilitate the acceptance of nuclear energy in a way suited to the level of knowledge of the visitors. A modern interactive exhibition of 150 m{sup 2} allows visitors to find out more about energy, CEA Cadarache research programs, radioactive waste management and radiological impact on the research center activities. It also offers an auditorium for group discussions and for school groups to discover science through enjoyment. This communication center has received several thousand visitors since its opening on October 2011; the initial results of this experience are now available. It's possible to explain the design of this exhibition, to give some statistics on the number of the visitors

  16. CEA VARIABLE-THROAT VENTURI SCRUBBER EVALUATION

    EPA Science Inventory

    The report gives detailed results of fractional and overall mass efficiency tests of a Combustion Equipment Associates(CEA) variable-throat venturi scrubber. The tests were performed on a full-scale scrubber used for controlling particles and SOx emissions from a pulverized-coal-...

  17. Chief Joseph Kokanee Enhancement Project; Strobe Light Deterrent Efficacy Test and Fish Behavior Determination at Grand Coulee Dam Third Powerplant Forebay, 2005-2006 Annual Report.

    SciTech Connect

    Simmons, M.; Johnson, Robert; McKinstry, C.

    2006-03-01

    The construction of Grand Coulee and Chief Joseph dams on the Columbia River resulted in the complete extirpation of the anadromous fishery upstream of these structures. Today, this area is totally dependent upon resident fish resources to support local fisheries. The resident fishing is enhanced by an extensive stocking program for target species in the existing fishery, including kokanee (Oncorhynchus nerka kennerlyi) and rainbow trout (O. mykiss). The kokanee fishery in Lake Roosevelt has not been meeting the return goals set by fisheries managers despite the stocking program. Investigations of physical and biological factors that could affect the kokanee population found predation and entrainment had a significant impact on the fish population. In 1999 and 2000, walleye (Sander vitreum) consumed between 15% and 9%, respectively, of the hatchery kokanee within 41 days of their release, while results from a study in the late 1990s estimated that entrainment at Grand Coulee Dam could account for up to 30% of the total mortality of the stocked fish. To address the entrainment loss, the Bonneville Power Administration commissioned a study to determine if fish would avoid areas illuminated by strobe lights in the forebay of the third powerplant. This work was conducted by Pacific Northwest National Laboratory (PNNL) in conjunction with the Confederated Tribes of the Colville Reservation (Colville Confederated Tribes). From 2002 through 2004, six strobe lights were suspended in the center of the opening to the third powerplant forebay during summer months. Results from those studies indicated that fish appeared to be attracted to the illuminated area but only at night and when flow conditions within the third powerplant forebay were minimal. However, small but consistent results from these studies indicated that under high flow conditions, fish might be avoiding the lights. The 2005 study was designed to examine whether, under high flow conditions near the penstock

  18. CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors.

    PubMed

    Bacac, Marina; Klein, Christian; Umana, Pablo

    2016-08-01

    Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits tumor growth and generates a highly inflamed tumor microenvironment. PMID:27622073

  19. Food sources of total omega 3 fatty acids (18:3 + 20:5 + 22:6), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

    Cancer.gov

    Food sources of total omega 3 fatty acids (18:3 + 20:5 + 22:6), listed in descending order by percentages of their contribution to intake, based on data from the National Health and Nutrition Examination Survey 2005-2006

  20. Commissioning MMS

    NASA Technical Reports Server (NTRS)

    Wood, Paul; Gramling, Cheryl; Stone, John; Smith, Patrick; Reiter, Jenifer

    2016-01-01

    This paper discusses commissioning of NASAs Magnetospheric MultiScale (MMS) Mission. The mission includes four identical spacecraft with a large, complex set of instrumentation. The planning for and execution of commissioning for this mission is described. The paper concludes by discussing lessons learned.

  1. Education Cost Study, 2005-2006

    ERIC Educational Resources Information Center

    Washington Higher Education Coordinating Board, 2007

    2007-01-01

    Produced every four years by the Washington Higher Education Coordinating Board, the education cost study provides detailed instructional cost information for the state's public two-year and four-year institutions. The cost analysis is based on expenditures drawn from two sources: state Near-General Fund appropriations and tuition revenue. By…

  2. SUSCEPTIBILITY TO ANTIBIOTICS IN URINARY TRACT INFECTIONS IN A SECONDARY CARE SETTING FROM 2005-2006 AND 2010-2011, IN SÃO PAULO, BRAZIL: DATA FROM 11,943 URINE CULTURES

    PubMed Central

    Miranda, Érique José Peixoto De; Oliveira, Gerson Sobrinho Salvador De; Roque, Felício Lopes; Santos, Sílvia Regina Dos; Olmos, Rodrigo Diaz; Lotufo, Paulo Andrade

    2014-01-01

    Introduction: Urinary tract infection (UTI) has a high incidence and recurrence, therefore, treatment is empirical in the majority of cases. Objectives: The aim of this study was to analyze the urine cultures performed at a secondary hospital, during two periods, 2005-2006 and 2010-2011, and to estimate the microbial resistance. Patients and methods: We analyzed 11,943 aerobic urine cultures according to basic demographic data and susceptibility to antibiotics in accordance with the Clinical and Laboratory Standards Institute (CLSI) for Vitek 1 and 2. Results: Most of our cohort consisted of young adult females that were seen at the Emergency Department. E. coli was the most frequent (70.2%) among the 75 species isolated. Resistance of all isolates was ≥ 20% for trimethoprim/sulfamethoxazole (TMP/SMX), norfloxacin, nitrofurantoin, cefazolin and nalidixic acid. Although E. coli was more susceptible (resistance ≥ 20% for TMP/SMX and nalidixic acid) among all of the isolates, when classified by the number and percentage of antibiotic resistance. Global resistance to fluoroquinolones was approximately 12%. Risk factors for E. coli were female gender and an age less than 65 years. Men and patients older than 65 years of age, presented more resistant isolates. Extended spectrum beta-lactamases (ESBL) were identified in 173 out of 5,722 Gram-negative isolates (3.0%) between 2010 and 2011. Conclusion: E. coli was the most frequent microbe isolated in the urine cultures analyzed in this study. There was a significant evolution of bacterial resistance between the two periods studied. In particular, the rise of bacterial resistance to fluoroquinolones was concerning. PMID:25076433

  3. Use of food labels, awareness of nutritional programmes and participation in the special supplemental program for Women, Infants and Children (WIC): results from the National Health and Nutrition Examination Survey (2005-2006).

    PubMed

    Wojcicki, Janet M; Heyman, Melvin B

    2013-07-01

    Use of nutritional labels in choosing food is associated with healthier eating habits including lower fat intake. Current public health efforts are focusing on the revamping of nutritional labels to make them easier to read and use for the consumer. The study aims to assess the frequency of use of nutritional labels and awareness of the United States Department of Agriculture (USDA) nutritional programmes by low-income women including those participating in the Special Supplemental Nutrition Program for Women, Infants and Children (WIC) as surveyed in the National Health and Nutrition Examination Survey 2005-2006. Many low-income women do not regularly use the nutrition facts panel information on the food label and less than half had heard of the USDA Dietary Guidelines for Americans (38.9%). In multivariate logistic regression, we found that WIC participation was associated with reduced use of the nutrition facts panel in choosing food products [odds ratio (OR) 0.45, 95% confidence interval (CI) 0.22-0.91], the health claims information (OR 0.54, 95% CI 0.32-0.28) and the information on carbohydrates when deciding to buy a product (OR 0.44, 95% CI 0.20-0.97) in comparison with WIC eligible non-participants. Any intervention to improve use of nutritional labels and knowledge of the USDA's nutritional programmes needs to target low-income women, including WIC participants. Future studies should evaluate possible reasons for the low use of nutrition labels among WIC participants in comparison with eligible non-participants. PMID:22171961

  4. Simplifying CEA through Excel, VBA, and Subeq

    NASA Technical Reports Server (NTRS)

    Foster, Ryan

    2004-01-01

    Many people use compound equilibrium programs for very different reasons, varying from refrigerators to light bulbs to rockets. A commonly used equilibrium program is CEA. CEA can take various inputs such as pressure, temperature, and volume along with numerous reactants and run them through equilibrium equations to obtain valuable output information, including products formed and their relative amounts. A little over a year ago, Bonnie McBride created the program subeq with the goal to simplify the calling of CEA. Subeq was also designed to be called by other programs, including Excel, through the use of Visual Basic for Applications (VBA). The largest advantage of using Excel is that it allows the user to input the information in a colorful and user-friendly environment while allowing VBA to run subeq, which is in the form of a FORTRAN DLL (Dynamic Link Library). Calling subeq in this form makes it much faster than if it were converted to VBA. Since subeq requires such large lists of reactant and product names, all of which can't be passed in as an array, subeq had to be changed to accept very long strings of reactants and products. To pass this string and adjust the transfer of input and output parameters, the subeq DLL had to be changed. One program that does this is Compaq Visual FORTRAN, which allows DLLs to be edited, debugged, and compiled. Compaq Visual FORTRAN uses FORTRAN 90/95, which has additional features to that of FORTRAN 77. My goals this summer include finishing up the excel spreadsheet of subeq, which I started last summer, and putting it on the Internet so that others can use it without having to download my spreadsheet. To finish up the spreadsheet I will need to work on debugging current options and problems. I will also work on making it as robust as possible, so that all errors that may arise will be clearly communicated to the user. New features will be added old ones will be changed as I receive comments from people using the spreadsheet

  5. Aeroacoustics research in Europe: The CEAS-ASC report on 2013 highlights

    NASA Astrophysics Data System (ADS)

    Bennett, G. J.; Kennedy, J.; Meskell, C.; Carley, M.; Jordan, P.; Rice, H.

    2015-03-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2013, compiled from information provided to the ASC of the CEAS. During 2013, a number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights from other programmes funded by national programmes or by industry. Furthermore, a concise summary of the CEAS-ASC workshop "Atmospheric and Ground Effects on Aircraft Noise" held in Seville, Spain in September 2013 is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection. This issue of the "highlights" paper is dedicated to the memory of Prof. John A. Fitzpatrick, Professor of Mechanical Engineering, Trinity College Dublin, and a valued member of the Aeroacoustics Specialists Committee. John passed away in September 2012 and is fondly missed across the globe by the friends he made in the Aeroacoustics Community. This paper is edited by PhD graduates and colleagues of John's who conduct research in aeroacoustics, inspired by his thirst for knowledge.

  6. CEA TCB: A novel head-to-tail 2:1 T cell bispecific antibody for treatment of CEA-positive solid tumors

    PubMed Central

    Bacac, Marina; Klein, Christian; Umana, Pablo

    2016-01-01

    ABSTRACT Carcinoembryonic antigen T cell bispecific antibody (CEA TCB) is a bispecific antibody used to recognize CEA and CD3e via a novel molecular format (2:1) that induces T cell-mediated killing of CEA over-expressing tumors while sparing primary cells with low CEA expression. CEA TCB treatment inhibits tumor growth and generates a highly inflamed tumor microenvironment. PMID:27622073

  7. Aeroacoustics research in Europe: The CEAS-ASC report on 2014 highlights

    NASA Astrophysics Data System (ADS)

    Detandt, Yves

    2015-11-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. Each year the committee highlights some of the research and development projects in Europe. This paper is the 2014 issue of this collection of Aeroacoustic Highlights, compiled from informations submitted to the CEAS-ASC. The contributions are classified in different topics; the first categories being related to specific aeroacoustic challenges (airframe noise, fan and jet noise, helicopter noise, aircraft interior noise) and two last sections are respectively devoted to recent improvements and emerging techniques and to general advances in aeroacoustics. For each section, the present paper focus on accomplished projects, providing the state of the art in each research category in 2014. A number of research programmes involving aeroacoustics were funded by the European Commission. Some of the highlights from these programmes are summarised in this paper, as well as highlights funded by national programmes or by industry.

  8. Aeroacoustics research in Europe: The CEAS-ASC report on 2010 highlights

    NASA Astrophysics Data System (ADS)

    Balázs Nagy, Attila

    2011-10-01

    The Council of European Aerospace Societies (CEAS) Aeroacoustics Specialists Committee (ASC) supports and promotes the interests of the scientific and industrial aeroacoustics community on an European scale and European aeronautics activities internationally. In this context, "aeroacoustics" encompasses all aerospace acoustics and related areas. Each year the committee highlights some of the research and development projects in Europe. This paper is a report on highlights of aeroacoustics research in Europe in 2010, compiled from information provided to the ASC of the CEAS. At the end of 2010, project X-NOISE EV of the Seventh Framework Programme of the European Commission has been launched as a continuation of the X-Noise series, with objectives of reducing aircraft noise and reaching the goal set by the ACARE 2020 Vision. Some contributions submitted to the editor summarizes selected findings from European projects launched before or concluded in 2010, while other articles cover issues supported by national associations or by industries. Furthermore, a concise summary of the workshop on "Aeroacoustics of High-Speed Aircraft Propellers and Open Rotors" held in Warsaw in October is included in this report. Enquiries concerning all contributions should be addressed to the authors who are given at the end of each subsection.

  9. Complete solid state lighting (SSL) line at CEA LETI

    NASA Astrophysics Data System (ADS)

    Robin, I. C.; Ferret, P.; Dussaigne, A.; Bougerol, C.; Salomon, D.; Chen, X. J.; Charles, M.; Tchoulfian, P.; Gasse, A.; Lagrange, A.; Consonni, M.; Bono, H.; Levy, F.; Desieres, Y.; Aitmani, A.; Makram-Matta, S.; Bialic, E.; Gorrochategui, P.; Mendizabal, L.

    2014-09-01

    With a long experience in optoelectronics, CEA-LETI has focused on Light Emitting Diode (LED) lighting since 2006. Today, all the technical challenges in the implementation of GaN LED based solid state lighting (SSL) are addressed at CEA-LETI who is now an RandD player throughout the entire value chain of LED lighting. The SSL Line at CEA-LETI first deals with the simulation of the active structures and LED devices. Then the growth is addressed in particular 2D growth on 200 mm silicon substrates. Then, technological steps are developed for the fabrication of LED dies with innovative architectures. For instance, Versatile LED Array Devices are currently being developed with a dedicated μLED technology. The objective in this case is to achieve monolithical LED arrays reported and interconnected through a silicon submount. In addition to the required bonding and 3D integration technologies, new solutions for LED chip packaging, thermal management of LED lamps and luminaires are also addressed. LETI is also active in Smart Lighting concepts which offer the possibility of new application fields for SSL technologies. An example is the recent development at CEA LETI of Visible Light Communication Technology also called LiFi. With this technology, we demonstrated a transmission rate up to 10 Mb/s and real time HD-Video transmission.

  10. Application of a MABEL Approach for a T-Cell-Bispecific Monoclonal Antibody: CEA TCB.

    PubMed

    Dudal, Sherri; Hinton, Heather; Giusti, Anna M; Bacac, Marina; Muller, Magali; Fauti, Tanja; Colombetti, Sara; Heckel, Tobias; Giroud, Nicolas; Klein, Christian; Umaña, Pablo; Benincosa, Lisa; Bachl, Juergen; Singer, Thomas; Bray-French, Katharine

    2016-09-01

    CEA TCB is a novel T-cell-bispecific (TCB) antibody targeting the carcinoembryonic antigen (CEA) expressed on tumor cells and the CD3 epsilon chain (CD3e) present on T cells, which is currently in Phase 1 clinical trials (NCT02324257) for the treatment of CEA-positive solid tumors. Because the human CEA (hCEA) binder of CEA TCB does not cross-react with cynomolgus monkey and CEA is absent in rodents, alternative nonclinical safety evaluation approaches were considered. These included the development of a cynomolgus monkey cross-reactive homologous (surrogate) antibody (cyCEA TCB) for its evaluation in cynomolgus monkey and the development of double-transgenic mice, expressing hCEA and human CD3e (hCEA/hCD3e Tg), as a potential alternative species for nonclinical safety studies. However, a battery of nonclinical in vitro/ex vivo experiments demonstrated that neither of the previous approaches provided a suitable and pharmacologically relevant model to assess the safety of CEA TCB. Therefore, an alternative approach, a minimum anticipated biological effect level (MABEL), based on an in vitro tumor lysis assay was used to determine the starting dose for the first-in-human study. Using the most conservative approach to the MABEL assessment, a dose of 52 μg was selected as a safe starting dose for clinical study. PMID:27404941

  11. Surface expression and CEA binding of hnRNP M4 protein in HT29 colon cancer cells.

    PubMed

    Laguinge, Luciana; Bajenova, Olga; Bowden, Emma; Sayyah, Jacqueline; Thomas, Peter; Juhl, Hartmut

    2005-01-01

    Carcinoembryonic antigen (CEA) has been shown to participate in the progression and metastatic growth of colorectal cancer. However, its biological function remains elusive. Recently, we found that CEA protects colon cancer cells from undergoing apoptosis, suggesting a complex role that includes signal transduction activity. Additionally, it was reported that CEA binds to Kupffer cells and macrophages to a membrane-anchored homolog of heterogeneous nuclear protein M4 (hnRNP M4), which subsequently was named CEA-receptor (CEAR). Cytoplasmatic and membranous expression of CEAR in CEA-positive colon cancer tissues prompted us to analyze the CEA-CEAR interaction in HT29 colon cancer cells. Both, CEA and CEAR were found on the cell surface of HT29 cells, as demonstrated by confocal microscopy. Imaging analysis suggested co-localization and, thus, interaction of both molecules. To confirm this observation, immunoprecipitation experiments and Western blot analysis were performed and indicated binding of CEA and CEAR. Immunoprecipitation of CEA resulted in a pull down of CEAR. The pull down of CEAR correlated with the amount of CEA as demonstrated by ribozyme targeting of CEA. Finally, external treatment of HT29 cells with soluble CEA induced tyrosine phosphorylation of CEAR, suggesting a CEA-dependent role of CEAR in signal transduction. Future experiments will elucidate whether the CEA-CEAR interaction is involved in CEA's antiapoptotic role and mediates the prometastatic properties of CEA in colon cancer cells. PMID:15816515

  12. The CEA/CD3-Bispecific Antibody MEDI-565 (MT111) Binds a Nonlinear Epitope in the Full-Length but Not a Short Splice Variant of CEA

    PubMed Central

    Huang, Jiaqi; Brohawn, Philip; Morehouse, Chris; Lekstrom, Kristen; Baeuerle, Patrick A.; Wu, Herren; Yao, Yihong; Coats, Steven R.; Dall’Acqua, William; Damschroder, Melissa; Hammond, Scott A.

    2012-01-01

    MEDI-565 (also known as MT111) is a bispecific T-cell engager (BiTE®) antibody in development for the treatment of patients with cancers expressing carcinoembryonic antigen (CEA). MEDI-565 binds CEA on cancer cells and CD3 on T cells to induce T-cell mediated killing of cancer cells. To understand the molecular basis of human CEA recognition by MEDI-565 and how polymorphisms and spliced forms of CEA may affect MEDI-565 activity, we mapped the epitope of MEDI-565 on CEA using mutagenesis and homology modeling approaches. We found that MEDI-565 recognized a conformational epitope in the A2 domain comprised of amino acids 326–349 and 388–410, with critical residues F326, T328, N333, V388, G389, P390, E392, I408, and N410. Two non-synonymous single-nucleotide polymorphisms (SNPs) (rs10407503, rs7249230) were identified in the epitope region, but they are found at low homozygosity rates. Searching the National Center for Biotechnology Information GenBank® database, we further identified a single, previously uncharacterized mRNA splice variant of CEA that lacks a portion of the N-terminal domain, the A1 and B1 domains, and a large portion of the A2 domain. Real-time quantitative polymerase chain reaction analysis of multiple cancers showed widespread expression of full-length CEA in these tumors, with less frequent but concordant expression of the CEA splice variant. Because the epitope was largely absent from the CEA splice variant, MEDI-565 did not bind or mediate T-cell killing of cells solely expressing this form of CEA. In addition, the splice variant did not interfere with MEDI-565 binding or activity when co-expressed with full-length CEA. Thus MEDI-565 may broadly target CEA-positive tumors without regard for expression of the short splice variant of CEA. Together our data suggest that MEDI-565 activity will neither be impacted by SNPs nor by a splice variant of CEA. PMID:22574157

  13. Economic Commission Report

    ERIC Educational Resources Information Center

    American Indian Journal, 1977

    1977-01-01

    Summarizing presentations and discussions of the Economic Commission of the International Non-Governmental Organizations Conference on Discrimination Against Indigenous Populations (1977), this report addresses: multinational corporations; the land question; and the Commission's recommended "Plan of Action". (JC)

  14. Baseline carcinoembryonic antigen (CEA) serum levels predict bevacizumab-based treatment response in metastatic colorectal cancer

    PubMed Central

    Prager, Gerald W; Braemswig, Kira H; Martel, Alexandra; Unseld, Matthias; Heinze, Georg; Brodowicz, Thomas; Scheithauer, Werner; Kornek, Gabriela; Zielinski, Christoph C

    2014-01-01

    Carcinoembryonic antigen (CEA) affects tumorigenesis by enhancing tumor cell survival and by inducing tumor angiogenesis. This study aimed to evaluate baseline CEA serum levels to predict bevacizumab-based therapy effect and survival in patients with metastatic colorectal cancer (mCRC). Two hundred and ninety eight mCRC patients receiving chemotherapy plus either bevacizumab or cetuximab were analyzed in a retrospective study. Disease control (DC), progression-free survival (PFS), and overall survival were assessed and related to pretreatment CEA serum levels. Patients with baseline CEA serum levels below the statistical median of 26.8 ng/mL (group I) were compared with patients with higher CEA levels (group II). The cetuximab-based treatment cohort was analyzed for specificity assessment of CEA to predict the anti-vascular endothelial growth factor effect in mCRC. Baseline CEA serum levels inversely correlated with therapeutic response in patients receiving bevacizumab-based treatment (disease control rate, 84% vs 60%), inversely correlated with median PFS leading to a median PFS benefit of 2.1 months for patients in group I when compared with group II, as well as inversely correlated with median overall survival (37.5 months vs 21.4 months). In an independent cohort of 129 patients treated with cetuximab-based therapy, no association of therapeutic response or PFS with CEA serum levels was found. As expected, baseline CEA levels were prognostic for mCRC. These data give first evidence that baseline serum CEA levels might constitute an important predictor for the efficacy of first-line bevacizumab-based therapy in patients with mCRC. Previously, we found that CEA induces angiogenesis independent of VEGF. The data presented here now give first evidence that baseline serum CEA levels in patients might constitute an important predictor for the efficacy of first-line bevacizumab-based therapy for metastatic colorectal cancer. PMID:24850362

  15. A clean bill of health? The efficacy of an NHS commissioned outsourced police custody healthcare service.

    PubMed

    de Viggiani, Nick

    2013-08-01

    Police custody healthcare services for detainees in the UK are most commonly outsourced to independent healthcare providers who employ custody nurses and forensic physicians to deliver forensic healthcare services. A pilot was introduced in 2008 by the Department of Health to explore the efficacy of commissioning custody healthcare via the NHS, in the wake of the 2005-2006 shift of prison healthcare to the NHS. The objective was to improve quality and accountability through NHS commissioning and the introduction of NHS governance to the management and delivery of custody healthcare. This article discusses key themes that arose from the project evaluation, which focused on the commissioning relationship between the police, the NHS commissioner and the private healthcare provider. The evaluation observed an evolving relationship between the police, the local NHS and the front-line nurses, which was complicated by the quite distinctive professional values and ideologies operating, with their contrasting organisational imperatives and discordant values and principles. A key challenge for commissioners is to develop synergy between operational and strategically located stakeholders so that they can work effectively towards common goals. Government policy appears to remain focused on creating safe, supportive and humane custody environments that balance criminal justice and health imperatives and support the rights and needs of detainees, victims, professionals and the public. This remains an ambitious agenda and presents a major challenge for new criminal justice health partnerships. PMID:23910844

  16. Relationship between serum CA19-9 and CEA levels and prognosis of pancreatic cancer

    PubMed Central

    Wu, Lei; Huang, Peijun; Wang, Fang; Li, Daqian; Xie, Erfu; Zhang, Yan

    2015-01-01

    Background To explore the relationship between preoperative serum CA19-9 and CEA levels and prognosis of pancreatic cancer (PC). Methods The clinicopathological data of 128 patients with pancreatic adenocarcinoma who were treated in our center between January 2012 and December 2013 were retrospectively analyzed. The relationships between serum CA19-9 and CEA levels and survival were analyzed using Kaplan-Meier method, log-rank test, and Cox regression analysis. The cut-off values for serum CA19-9 and CEA levels were 39 U/mL and 4.7 ng/mL, respectively. Results Among these 128 patients, the mean age was 62 years, and median survival was 12.2 days. The positive rate of CA19-9 and CEA was 78.1% and 37.5%, respectively. Patients with increased CA19-9 or CEA level suffered a poorer prognosis than those with normal CA19-9 or CEA level (CA19-9: P=0.027; CEA: P=0.036). Cox logistic analysis revealed that lymphatic metastasis, CA19-9 >39 U/mL, and CEA >4.7 ng/mL were independent prognostic factors in patients with pancreatic carcinoma. Conclusions Preoperative serum CA19-9 and CEA level are closely related with survival time in PC patients and therefore may be used for evaluating the prognosis for PC. PMID:26734638

  17. Serum CEA testing in the post-operative surveillance of colorectal carcinoma.

    PubMed Central

    Hine, K. R.; Dykes, P. W.

    1984-01-01

    Six hundred and sixty-three patients were followed with serial serum CEA measurements in addition to routine clinical surveillance after radical resection of colorectal carcinoma. Of 626 available for analysis, 366 (58.4%) remained clinically free of recurrence and had a normal CEA (less than 20 ng ml-1) throughout and 89 (14.2%) had a temporary non-progressive rise in CEA with no evidence of secondary disease. Of 171 patients who developed proven or suggestive recurrence, 114 had a preceding rise in the serum CEA and in further 21 the CEA rose simultaneously with recurrence. In 36 patients secondary disease was detected while the CEA was still within normal limits. CEA was more effective as an early index of distant metastasis, thus in 76% of those patients with a preceding rise in CEA, the secondary disease was disseminated, whereas only 20% had localised recurrence. The pattern of rise in CEA was of no practical value in distinguishing localised from distant recurrence. PMID:6733018

  18. Commissioning HVAC systems

    SciTech Connect

    Schiess, K.

    1995-12-01

    In recent years, commissioning has been viewed as a separate process that had to be specified and implemented by a specialized entity. This article discusses commissioning in the HVAC field and looks at it from an international perspective. The author has worked in Europe, South Africa (British system) and the USA. The differences between the British and the American methods of commissioning are discussed, with examples given where the American way was unsuccessful. It is the design engineer`s job to test and accept (commission) an installation after the contractor has demonstrated the performance to the satisfaction of the design engineer. Once the plant is commissioned, it is put into service.

  19. A Review of 25 Years of Corrosion Studies on HLW Container Materials at the CEA

    SciTech Connect

    Helie, Max

    2007-07-01

    The Commissariat a l'Energie Atomique (CEA, French Atomic Energy Commission) has been involved in researches on nuclear waste management for more than 25 years. One of the key issues is the prediction of the long term behavior and aging of the High Level Waste (HLW) containers in order to develop concepts that will ensure the confinement of the activity over extremely long periods of time. Preliminary studies were carried out on two concepts, one of a thin 'corrosion resistant' container made of titanium or nickel base alloy, and the other on a thick 'corrosion allowance' container made or carbon steel. The results of these experiments showed that the 'corrosion resistant' concept led to a high uncertainty on the development and propagation rate of localized forms of corrosion, and the concept of geological disposal in an argillaceous host formation of thick waste containers made of carbon steel was chosen as the reference for further studies. This eventually led to the voting of a law relative to nuclear waste management on June 28 2006, which endorses the geological disposal of corrosion allowance containers as the reference solution, while stating than an effort must be kept on the research on actinides transmutation to reduce the time during which a geological disposal facility has to be proven capable to ensure the confinement of the radioactive waste. Studies are still in progress to better assess the corrosion mechanisms relevant to this situation in order to provide reliable models for the long term prediction of the containers corrosion behavior. (author)

  20. In vivo kinetics of radiolabeled monoclonal anti-CEA antibodies in animal models

    SciTech Connect

    Hagan, P.L.; Halpern, S.E.; Chen, A.; Krishnan, L.; Frincke, J.; Bartholomew, R.M.; David, G.S.; Carlo, D.

    1985-12-01

    Studies were performed to determine the effect of the radiolabel and circulating carcinoembryonic antigen (CEA) on the pharmacodynamics of monoclonal anti-CEA antibodies (MoAbs). The studies were performed in normal BALB/c mice and in nude mice bearing human colon tumors. Three different tumors were used, each of which produced CEA levels characteristic of that particular tumor's secretory rate. The CEJ-326 MoAb labeled with either 111In or 125I was used in all studies. Circulating CEA induced the removal of 125I and 111In MoAbs from the vascular compartment. Liver concentrations of 111In increased and 125I levels decreased as the CEA secretory rate of the tumor rose. This indicates that circulating CEA complexes form in the vascular compartment which, in an animal model, are removed by the liver and spleen. This results in decreased tumor uptake of the labeled MoAb. The iodinated MoAb complexes are dehalogenated while the 111In is retained by the liver. This dehalogenation may account for the relatively low liver activity observed in radioimmunoimaging with intact radioiodinated anti-CEA MoAbs, provided the CEA complexes are similarly removed from the vascular compartment by the human liver.

  1. Wind River Watershed Restoration, 2005-2006 Annual Report.

    SciTech Connect

    Jezorek, Ian G.; Connolly, Patrick J.; Munz, Carrie

    2008-11-10

    This report summarizes work completed by U.S. Geological Survey's Columbia River Research Laboratory (USGS-CRRL) in the Wind River subbasin during the period April 2005 through March 2006 under Bonneville Power Administration (BPA) contract 22095. During this period, we collected temperature, flow, and habitat data to characterize habitat condition and variation within and among tributaries and mainstem sections in the Wind River subbasin. We also conducted electrofishing and snorkeling surveys to determine juvenile salmonid populations within select study areas throughout the subbasin. Portions of this work were completed with additional funding from U.S. Fish and Wildlife Service (USFWS) and the Lower Columbia Fish Enhancement Group (LCFEG). A statement of work (SOW) was submitted to BPA in March 2005 that outlined work to be performed by USGS-CRRL. The SOW was organized by work elements, with each describing a research task. This report summarizes the progress completed under each work element.

  2. Delaware Education State Report Card, 2005-2006

    ERIC Educational Resources Information Center

    Delaware Department of Education, 2007

    2007-01-01

    This report, submitted to the U.S. Department of Education, contains summary details of Delaware students' growth in the areas of reading, mathematics, writing, science and social studies. The results reported herein are part of a long-term effort to gather data on Delaware students' educational progress and use the data to inform decisions about…

  3. Arkansas Department of Education Home School Report, 2005-2006

    ERIC Educational Resources Information Center

    Arkansas Department of Education, 2006

    2006-01-01

    This report presents data on home schooling in the state of Arkansas that covers: students withdrawn from home school; home school student count by county, district, and grade level; and home school enrollments by grade and gender. The report contains the texts of the Arkansas Code Annotated Section 6-15-501 through Section 6-15-508 Home School…

  4. Guide to NYC Small High Schools, 2005-2006

    ERIC Educational Resources Information Center

    New Visions for Public Schools, 2005

    2005-01-01

    New Visions for Public Schools has put together "The New York City Guide to Small High Schools" to describe new opportunities in the public high school system: over 200 small secondary schools created over the last five years. These small schools are part of the Department of Education's efforts to create more choices for thousands of students…

  5. Annual Site Environmental Report for Calendar Years 2005-2006

    SciTech Connect

    Virginia L. Finley

    2010-01-25

    Contained in the following report are data for radioactivity in the environment collected and analyzed by Princeton Plasma Physics Laboratory's Princeton Environmental, Analytical, and Radiological Laboratory (PEARL). The PEARL is located on-site and is certified for analyzing radiological and non-radiological parameters through the New Jersey Department of Environmental Protection's Laboratory Certification Program, Certification Number 12471. Non-radiological surface and ground water samples are analyzed by NJDEP certified subcontractor laboratories - QC, Inc. and Accutest Laboratory. To the best of our knowledge, these data, as contained in the "Annual Site Environmental Report for 2005 and 2006," are documented and certified to be correct.

  6. Patterns of stepping cadence in the 2005-2006 NHANES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Laboratory studies of adult walking behavior have consistently found that a cadence of 100 steps/min is a reasonable threshold for moderate intensity. The purpose of this study was to determine cadence patterns in free-living adults, and in particular, time spent at increasing cadence increments, in...

  7. 2005-2006 MINERAL PROCESSING AND MINING NATIONAL PRIORITY

    EPA Science Inventory

    The US-EPA Office of Enforcement and Compliance Assurance (OECA) has implemented a national initiative for the mineral processing and mining industry. As part of the initiative, US-EPA Region 4 inspected and conducted sampling at nine of these facilities during this reporting pe...

  8. Parabolic Trough VSHOT Optical Characterization in 2005-2006 (Presentation)

    SciTech Connect

    Wendelin, T.

    2006-02-01

    This presentation regarding parabolic trough VSHOT optical characterization describes trough deployment and operation phases including: development, manufacture/installation, and maintenance/operation.

  9. Flathead River Focus Watershed Coordinator, 2005-2006 Annual Report.

    SciTech Connect

    DuCharme, Lynn

    2006-05-01

    The Bonneville Power Administration (BPA) has long been involved with funding of the Cooperative Habitat Protection and Improvement with Private Landowners program in accordance with the Northwest Power Planning Council's (NPPC) Fish & Wildlife Program (Section 7.7). Section 7.7B.1 requires the establishment of ''at least one model watershed coordinator selected by each representative state''. This project was initiated in 1997 with the purpose of fulfilling the NWPCC's watershed program within the Flathead River basin in western Montana. Currently, the Flathead watershed has been radically altered by hydropower and other land uses. With the construction of Hungry Horse, Bigfork and Kerr dams, the Flathead River system has been divided into isolated populations. Bull trout have been listed as threatened by the US Fish and Wildlife Service and westslope cutthroat trout have been petitioned for listing. Many streams in the drainage have been destabilized during recent decades. Past legal and illegal species introductions are also causing problems. This project fosters in-kind, out-of-place mitigation to offset the impacts of hydroelectric power to 72 miles of the South Fork of the Flathead River and its tributaries upstream of Hungry Horse Dam. Key subbasins within the Flathead drainage, which are critical to native species restoration, are experiencing rapid changes in land ownership and management direction. Subdivision and residential development of agricultural and timber lands adjacent to waterways in the drainage pose one of the greatest threats to weak but recoverable stocks of trout species. Plum Creek Timber Company, a major landholder in the Flathead drainage is currently divesting itself of large tracks of its lakeshore and streamside holdings. Growth of small tract development throughout the area and its tributaries is occurring at a record rate. Immediate to short-term action is required to protect stream corridors through many of these areas if cost-effective recovery efforts are to be implemented. In order to adequately address the issues, other segments of society and other (non-BPA) funding sources must be incorporated into the solution. As stated in the 1994 Fish and Wildlife Program (section 7.7), ''Comprehensive watershed management should enhance and expedite implementation of actions by clearly identifying gaps in programs and knowledge, by striving over time to resolve conflicts, and by keying on activities that address priorities''. A watershed coordinator helps to initiate and facilitate efforts for addressing the issues mentioned above and pulling together a plan for mitigation. Local support is essential before local governments and individual citizens are going to allow government initiatives to be implemented.

  10. Multiwavelength observations of Markarian 421 in 2005-2006.

    SciTech Connect

    Horan, D.; Acciari, V. A.; Bradury, S. M.; Buckley, J. H.; Bugaev, V.; Byrum, K.; Smith, A. W.; Hays, E.

    2009-01-01

    Since 2005 September, the Whipple 10 m Gamma-ray Telescope has been operated primarily as a blazar monitor. The five northern hemisphere blazars that have already been detected at the Whipple Observatory, Markarian 421 (Mrk 421), H1426+428, Mrk 501, 1ES 1959+650, and 1ES 2344+514, are monitored routinely each night that they are visible. We report on the Mrk 421 observations taken from 2005 November to 2006 June in the gamma-ray, X-ray, optical, and radio bands. During this time, Mrk 421 was found to be variable at all wavelengths probed. Both the variability and the correlations among different energy regimes are studied in detail here. A tentative correlation, with large spread, was measured between the X-ray and gamma-ray bands, while no clear correlation was evident among the other energy bands. In addition to this, the well-sampled spectral energy distribution of Mrk 421 (1101+384) is presented for three different activity levels. The observations of the other blazar targets will be reported separately.

  11. Soil Water Trends During the 2005 - 2006 Drought in Oklahoma

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Soil water depletion is an early consequence of a meteorological drought, with the latter defined as a precipitation deficit lasting a few months to several years. Soil water in the upper soil profile (approximately first meter) is limited and highly variable because of its rapid response to precipi...

  12. Illinois Community College Board Biennial Report, 2005-2006

    ERIC Educational Resources Information Center

    Illinois Community College Board, 2006

    2006-01-01

    The mission of the Illinois Community College Board (ICCB), as the state coordinating board for community colleges, is to administer the Public Community College Act in a manner that maximizes the ability of the community colleges to serve their communities, promotes cooperation within the system, and accommodates those State of Illinois…

  13. New Mexico Student Dropout Report, 2005-2006. Revised

    ERIC Educational Resources Information Center

    Medrano, Marlene; Borgrink, Henry

    2007-01-01

    The New Mexico Dropout Report is published annually to provide information for educators, parents, legislators, and other interested parties on the status of education in New Mexico. This report describes the extent and nature of the school dropout dilemma in the state, providing information on the numbers and percentages of dropouts by grade,…

  14. MCPS Special Education at a Glance 2005-2006

    ERIC Educational Resources Information Center

    Montgomery County Public Schools, 2006

    2006-01-01

    "MCPS Special Education at a Glance" is a direct result of the work of the Special Education Continuous Improvement Team (SECIT), an advisory group to the Montgomery County Public Schools Board of Education Special Education Ad Hoc Subcommittee. During the 2004-2005 school year, the SECIT developed, in collaboration with special…

  15. Appeal Resource and Training Consortium (ARTC) 2005-2006

    ERIC Educational Resources Information Center

    Online Submission, 2006

    2006-01-01

    APPEAL (Asia Pacific Programme of Education for All) Resource and Training Consortium (ARTC) was initiated in May 1997 at the Technical Working Group Meeting organized by APPEAL in cooperation with the Indian Institute of Education (IIE) to provide technical support and assistance to the work of APPEAL among the Member States. This booklet is a…

  16. Kalispel Resident Fish Project, 2005-2006 Annual Report.

    SciTech Connect

    Olson, Jason; Andersen, Todd

    2006-07-01

    In 2005 the Kalispel Natural Resource Department (KNRD) monitored its current enhancement projects for bull trout (Salvelinus confluentus) and westslope cutthroat trout (Oncorhynchus clarki lewisi). Largemouth Bass (Micropterus salmoides) enhancement projects were also monitored. Additional baseline fish population and habitat assessments were conducted, in East River and several of its tributaries.

  17. CEA in policies and plans: UK case studies

    SciTech Connect

    Cooper, Lourdes M.

    2011-09-15

    This paper examines how cumulative effects assessment (CEA) has been considered in Strategic Environmental Assessments (SEA) of regional and local plans in a number of case studies in the UK. Initially, the paper presents the legislative and regulatory requirements for assessing cumulative effects in plans and programmes in the UK. The two approaches for assessing plans in the UK, Sustainability Appraisal (SA) and SEA are discussed and in most cases, a combined SA and SEA process is undertaken by Regional and Local Planning Authorities. The strengths and weaknesses of this approach are explored, as well as their usefulness in decision making. There are problems relating to baseline, establishing trends and predicting cumulative effects at the strategic level. The issues in assessing cumulative effects within this SA/SEA framework are discussed and recommendations for improvements are made.

  18. Cryogenic turbulence test facilities at CEA/SBT

    NASA Astrophysics Data System (ADS)

    Rousset, B.; Baudet, C.; Bon Mardion, M.; Bourgoin, M.; Braslau, A.; Daviaud, F.; Diribarne, P.; Dubrulle, B.; Gagne, Y.; Gallet, B.; Gibert, M.; Girard, A.; Lehner, T.; Moukharski, I.; Sy, F.

    2015-12-01

    Recently, CEA Grenoble SBT has designed, built and tested three liquid helium facilities dedicated to turbulence studies. All these experiments can operate either in HeI or HeII within the same campaign. The three facilities utilize moving parts inside liquid helium. The SHREK experiment is a von Kármán swirling flow between 0.72 m diameter counterrotating disks equipped with blades. The HeJet facility is used to produce a liquid helium free jet inside a 0.200 m I.D., 0.47 m length stainless steel cylindrical testing chamber. The OGRES experiment consists of an optical cryostat equipped with a particle injection device and an oscillating grid. We detail specific techniques employed to accommodate these stringent specifications. Solutions for operating these facilities without bubbles nor boiling/cavitation are described. Control parameters as well as Reynolds number and temperature ranges are given.

  19. Guidelines for residential commissioning

    SciTech Connect

    Wray, Craig P.; Walker, Iain S.; Sherman, Max H.

    2003-01-31

    Currently, houses do not perform optimally or even as many codes and forecasts predict, largely because they are field assembled and there is no consistent process to identify problems or to correct them. Residential commissioning is a solution to this problem. This guide is the culmination of a 30-month project that began in September 1999. The ultimate objective of the project is to increase the number of houses that undergo commissioning, which will improve the quality, comfort, and safety of homes for California citizens. The project goal is to lay the groundwork for a residential commissioning industry in California focused on end-use energy and non-energy issues. As such, we intend this guide to be a beginning and not an end. Our intent is that the guide will lead to the programmatic integration of commissioning with other building industry processes, which in turn will provide more value to a single site visit for people such as home energy auditors and raters, home inspectors, and building performance contractors. Project work to support the development of this guide includes: a literature review and annotated bibliography, which facilitates access to 469 documents related to residential commissioning published over the past 20 years (Wray et al. 2000), an analysis of the potential benefits one can realistically expect from commissioning new and existing California houses (Matson et al. 2002), and an assessment of 107 diagnostic tools for evaluating residential commissioning metrics (Wray et al. 2002). In this guide, we describe the issues that non-experts should consider in developing a commissioning program to achieve the benefits we have identified. We do this by providing specific recommendations about: how to structure the commissioning process, which diagnostics to use, and how to use them to commission new and existing houses. Using examples, we also demonstrate the potential benefits of applying the recommended whole-house commissioning approach to

  20. THE COLLEGE COMMISSIONS.

    ERIC Educational Resources Information Center

    FOOKS, JOYCE LANE

    THE HISTORIES, ORGANIZATIONAL STRUCTURES, MODES OF OPERATION, GOALS, AND SPECIFIC ACTIVITIES OF EIGHT COLLEGE SCIENCE COMMISSIONS ARE PRESENTED. THE GOAL OF THE EIGHT COLLEGE SCIENCE COMMISSIONS IS TO BRING UNDERGRADUATE SCIENCE INSTRUCTION CLOSER TO THE RESEARCH FRONTIER, UPDATE COURSES, AND FOSTER THE SPIRIT OF INQUIRY. INTERCOMMISSION…

  1. Commissioning of HVAC systems

    SciTech Connect

    Schiess, K.

    1995-06-01

    In recent years various presentation and discussions have taken place which looked at commissioning as a separate process that had to be specified and implemented by a specialized entity in a project. This presentation discusses commissioning in the HVAC field and looks at it from an international perspective. The author has worked in Europe, South Africa (British system) and in the USA. The differences are discussed between the British and the American methods with some examples where the American way of commissioning was unsuccessful. The conclusion is that it is the design engineer`s job to test and accept (commission) an installation after the contractor has demonstrated the performance to the satisfaction of the design engineer. Once the plant is commissioned, it is put into service.

  2. A Phase I Study of a Combination of Yttrium-90 labeled Anti-CEA Antibody and Gemcitabine in Patients with CEA Producing Advanced Malignancies

    PubMed Central

    Shibata, Stephen; Raubitschek, Andrew; Leong, Lucille; Koczywas, Marianna; Williams, Lawrence; Zhan, Jiping; Wong, Jeffrey Y.C.

    2011-01-01

    Purpose To determine the maximum tolerated dose of combined therapy using an yttrium-90 labeled anti-CEA antibody with gemcitabine in patients with advanced CEA producing solid tumors. Experimental Design The chimeric human/murine cT84.66 is an anti-CEA intact IgG1, with high affinity and specificity to CEA. This was given at a fixed yttrium-90 labeled dose of 16.6 mCi/m2 to subjects who had and an elevated CEA in serum or in tumor by immunohistochemistry. Also required was a tumor that imaged with an 111In labeled cT84.66 antibody. Patients were treated with escalating doses of gemcitabine given intravenously over 30 minutes on day 1 and 3 after the infusion of the yttrium-90 labeled antibody. Patients were treated in cohorts of 3. The maximum tolerated dose was determined as the highest level at which no more than 1 of 6 patients experienced a dose limiting toxicity. Results A total of 36 patients were enrolled, and all but one had prior systemic therapy. The maximum tolerated dose of gemcitabine in this combination was 150mg/m2. Dose limiting toxicities at a gemcitabine dose of 165mg/m2 included a grade 3 rash and grade 4 neutropenia. One partial response was seen in a patient with colorectal cancer, and 4 patients had a > 50% decrease in baseline CEA levels associated with stable disease. Human antichimeric antibody responses were the primary reason for stopping treatment in 12 patients. Conclusions feasibility of combining gemcitabine with an yttrium-90 labeled anti-CEA antibody is demonstrated with preliminary evidence of clinical response. PMID:19351765

  3. French Atomic Energy Commission Decommissioning Programme and Feedback Experience - 12230

    SciTech Connect

    Guiberteau, Ph.; Nokhamzon, J.G.

    2012-07-01

    Since the French Atomic and Alternatives Energy Commission (CEA) was founded in 1945 to carry out research programmes on use of nuclear, and its application France has set up and run various types of installations: research or prototypes reactors, process study or examination laboratories, pilot installations, accelerators, nuclear power plants and processing facilities. Some of these are currently being dismantled or must be dismantled soon so that the DEN, the Nuclear Energy Division, can construct new equipment and thus have available a range of R and D facilities in line with the issues of the nuclear industry of the future. Since the 1960's and 1970's in all its centres, the CEA has acquired experience and know-how through dismantling various nuclear facilities. The dismantling techniques are nowadays operational, even if sometimes certain specific developments are necessary to reduce the cost of operations. Thanks to availability of techniques and guarantees of dismantling programme financing now from two dedicated funds, close to euro 15,000 M for the next thirty years, for current or projected dismantling operations, the CEA's Nuclear Energy Division has been able to develop, when necessary, its immediate dismantling strategy. Currently, nearly thirty facilities are being dismantled by the CEA's Nuclear Energy Division operational units with industrial partners. Thus the next decade will see completion of the dismantling and radioactive clean-up of the Grenoble site and of the facilities on the Fontenay-aux-Roses site. By 2016, the dismantling of the UP1 plant at Marcoule, the largest dismantling work in France, will be well advanced, with all the process equipment dismantled. After an overview of the French regulatory framework, the paper will describe the DD and R (Decontamination Decommissioning and Remediation) strategy, programme and feedback experience inside the CEA's Nuclear Energy Division. A special feature of dismantling operations at the CEA

  4. Electrochromic sensing platform based on steric hindrance effects for CEA detection.

    PubMed

    Zhai, Qingfeng; Zhang, Xiaowei; Xia, Yong; Li, Jing; Wang, Erkang

    2016-06-20

    In this work, an electrochromic sensing platform with prussian blue (PB) as the indicator was proposed for signaling carcinoembryonic antigen (CEA) using the bipolar electrode (BPE) system. The CEA aptamer was pre-anchored on the anode pole of the BPE for capturing CEA through strong binding affinity. The presence of CEA induced the increase of steric hindrance and led to lower electrochemical currents. Due to the quantitative relationship between the two reactions occurring at both ends of the BPE, the amount of deposited PB in situ can be used as an indicator for reporting target protein concentration. Using CEA concentration in normal human serum as a reference (5 ng mL(-1)), this electrochromic sensing platform can be used for distinguishing persons with cancer from normal humans easily and quickly, which is very important for subsequent treatment of patients. This novel electrochromic platform has great selectivity for target tumor proteins and provides a fast, visual method for CEA detection. Finally, the proposed biosensor can be applied to detect CEA in human serum, which holds great potential for point-of-care diagnostics combined with the advantage of the closed BPE system. PMID:27160521

  5. Selectively assaying CEA based on a creative strategy of gold nanoparticles enhancing silver nanoclusters' fluorescence.

    PubMed

    Yang, Xiaoming; Zhuo, Yan; Zhu, Shanshan; Luo, Yawen; Feng, Yuanjiao; Xu, Yan

    2015-02-15

    Herein, we have successfully built up connections between nanoparticles and nanoclusters, and further constructed a surface-enhanced fluorescence (SEF) strategy based on the two types of nanomaterials for selectively assaying carcinoembryonic antigen (CEA). Specifically, silver nanoclusters provided the original fluorescence signal, while gold nanoparticles modified with DNA served as the fluorescence enhancer simultaneously. On the basis of this proposed nano-system, the two nanomaterials were linked by CEA-aptamer, thus facilitating SEF occurring. Nevertheless, more competitive interactions between CEA and CEA-aptamer emerged once CEA added, leading to SEF failed and their fluorescence decreased. Significantly, this creative method was further applied to detect CEA, and showed the linear relationship between the fluorescence intensity and CEA concentrations in the range of 0.01-1 ng mL(-1) with a detection limit of 3 pg mL(-1) at a signal-to-noise ratio of 3, demonstrating its sensitivity and promising towards multiple applications. On the whole, this approach we established may broaden potential ways of combining nanoparticles and nanoclusters for detecting trace targets in bioanalytical fields. PMID:25259877

  6. Correlation between serum CEA levels and EGFR mutations in Chinese nonsmokers with lung adenocarcinoma

    PubMed Central

    Jin, Bo; Dong, Yu; Wang, Hui-min; Huang, Jin-su; Han, Bao-hui

    2014-01-01

    Aim: To evaluate the relationship between epidermal growth factor receptor (EGFR) mutations and serum carcinoembryonic antigen (CEA) levels in Chinese nonsmokers with pulmonary adenocarcinoma. Methods: We sequenced exons 18–21 of the EGFR gene in 98 cases. The patients were divided into two groups based on their pre-treatment serum CEA levels (below or above 5 ng/mL) for analyzing the correlations with EGFR mutations. Results: Sixty-seven cases harbored EGFR mutations. The rates of EGFR mutations and exon 19 mutations in the high-CEA group (78.2% and 49.1%, respectively) were significantly higher those in the low-CEA group (55.8% and 20.9%, respectively). Serum CEA levels were found to be the only independent predictor of EGFR mutation (OR 2.837; 95% CI: 1.178–6.829) and exon 19 mutation (OR 3.618; 95% CI: 1.319–9.918). Furthermore, a higher serum CEA level was associated with a higher EGFR mutation rate and a higher exon 19 mutation rate: patients with serum CEA levels <5 ng/mL, ≥5 and <20 ng/mL, ≥20 ng/mL showed the EGFR mutation rate of 55.8%, 74.1%, 82.1%, respectively, and the exon 19 mutation rate of 20.9%, 40.7%, 57.1%, respectively. Patients with EGFR mutations displayed a significantly higher incidence of abnormal serum CEA levels (>5 ng/mL) than patients without EGFR mutations (64.2% vs 38.7%). Conclusion: Elevated serum CEA levels predict the presence of EGFR gene mutations in Chinese nonsmokers with pulmonary adenocarcinoma. PMID:24487967

  7. Imaging of pharyngeal and laryngeal carcinomas with indium-111-labeled monoclonal anti-CEA antibodies

    SciTech Connect

    Kairemo, K.J.; Hopsu, E.V. )

    1990-10-01

    Localization of primary tumors, metastases, or recurrences in 13 consecutive patients with histological verification of squamous cell or adenocarcinoma was made with radioimmunodetection using monoclonal radiolabeled anti-CEA antibody. All surgical specimens stained immunohistochemically, except one, were positive for CEA. Of the known 19 tumor sites 17 were visualized in antibody scans. There were two positive findings that did not prove to be positive during 12 month follow-up. The scintigram findings did not correlate with CEA serum concentrations that, with one exception, were normal in all patients.

  8. Nuclear Regulatory Commission issuances

    SciTech Connect

    Not Available

    1994-03-01

    This report includes the issuances received during the specified period from Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM).

  9. Federal Trade Commission

    MedlinePlus

    ... Events Press Releases Commission Actions Media Resources Consumer Finance Mergers and Competition Mobile Technology The Do Not ... Advice For Consumers Business Center Advertising & Marketing Credit & Finance Guidance Privacy & Security Selected Industries Legal Resources Business ...

  10. Commissioning the LCLS Injector

    SciTech Connect

    Akre, R.; Dowell, D.; Emma, P.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Iverson, R.; Limborg-Deprey, C.; Loos, H.; Miahnahri, A.; Schmerge, J.; Turner, J.; Welch, J.; White, W.; Wu, J.; /SLAC

    2007-11-28

    The Linac Coherent Light Source (LCLS) is a SASE x-ray Free-Electron Laser (FEL) project presently under construction at SLAC. The injector section, from drive laser and RF photocathode gun through first bunch compressor chicane, was installed in fall 2006. Initial system commissioning with an electron beam was completed in August 2007, with the goal of a 1.2-micron emittance in a 1-nC bunch clearly demonstrated. The second phase of commissioning, including second bunch compressor and full linac, is planned for 2008, with FEL commissioning in 2009. We report experimental results and experience gained in the first phase of commissioning, including the photo-cathode drive laser, RF gun, photocathode, S-band and X-band RF systems, first bunch compressor, and the various beam diagnostics.

  11. Nuclear Regulatory Commission Issuances

    SciTech Connect

    1996-12-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM).

  12. Commission 53: Extrasolar Planets

    NASA Astrophysics Data System (ADS)

    Boss, Alan; Lecavelier des Etangs, Alain; Mayor, Michel; Bodenheimer, Peter; Collier-Cameron, Andrew; Kokubo, Eiichiro; Mardling, Rosemary; Minniti, Dante; Queloz, Didier

    2012-04-01

    Commission 53 was created at the 2006 Prague General Assembly (GA) of the IAU, in recognition of the outburst of astronomical progress in the field of extrasolar planet discovery, characterization, and theoretical work that has occurred since the discovery of the first planet in orbit around a solar-type star in 1995. Commission 53 is the logical successor to the IAU Working Group on Extrasolar Planets (WGESP), which ended its six years of existence in August 2006. The founding President of Commission 53 was Michael Mayor, in honor of his seminal contributions to this new field of astronomy. The current President is Alan Boss, the former chair of the WGESP. The current members of the Commission 53 (C53) Organizing Committee (OC) began their service in August 2009 at the conclusion of the Rio de Janeiro IAU GA.

  13. Commission 4: Ephemerides

    NASA Astrophysics Data System (ADS)

    Fukushima, Toshio; Kaplan, George H.; Krasinsky, George A.; Arlot, Jean-Eudes; Bangert, John A.; Hohenkerk, Catherine; Lara, Martin; Pitjeva, Elena V.; Urban, Sean E.; Vondrak, Jan

    2010-05-01

    Dr. George Kaplan, the current Vice-President of the Commission was nominated to be the new President. Dr. Catherine Hohenkerk was elected to be the next Vice-President of the Commission. As for the Membership of the Organizing Committee, Dr. Vondrak stepped down and Drs William Folkner of JPL and Steve Bell of HMNAO have been added. In the below, we present summaries of the reports from various institutions presented at the business session.

  14. SPEAR3 Commissioning

    SciTech Connect

    Harkay, K.; Sajaev, V.; Boland, M.J.; Tan, Y.E.; Krinsky, S.; Podobedov, B.; Decking, W.; Ropert, A.; Byrd, J.M.; Robin, D.; Scarvie, T.; Steier, C.; Fedurin, M.G.; Jines, P.; Chang, H.-P.; Kuo, C.-C.; Tsai, H.-J.; Yoon, M.H.; Boge, M.; Allison, S.; Bellomo, P.; /SLAC, SSRL /SOLEIL, Saint-Aubin

    2005-05-09

    The successful commissioning of the new SPEAR3 light source at the Stanford Synchrotron Radiation Laboratory (SSRL) will be reviewed. Orbit control, beam-based alignment, and an orbit interlock were commissioned. Orbit motion was characterized as a function of frequency. The linear optics was corrected for ID focusing and coupling errors. The nonlinear optics were investigated with dynamic aperture measurements as a function of energy and tune.

  15. Amorphous silicon technology improvement at CEA-LETI

    NASA Astrophysics Data System (ADS)

    Mottin, Eric; Bain, Astrid; Castelein, Pierre; Ouvrier-Buffet, Jean-Louis; Tissot, Jean-Luc; Yon, Jean-Jacques; Chatard, Jean-Pierre

    2002-05-01

    The emergence of uncooled infrared detectors has opened new opportunities for IR imaging both for military and civil applications. Infrared imaging sensors that operate without cryogenic cooling have the potential to provide the military or civilian users with infrared vision capabilities packaged in a camera of extremely small size, weight and power. Uncooled infrared sensor technology has advanced rapidly in the past few years. Higher performance sensors, electronics integration at the sensor, and new concepts for signal processing are generating advanced infrared focal plane arrays. This would significantly reduce the cost and accelerate the implementation of sensors for applications such as surveillance or predictive maintenance. We present the uncooled infrared detector operation principle and the development at CEA/LETI from the 256 x 64 with a pitch of 50 micrometers to the 320 x 240 with a pitch of 35 micrometers . LETI has been involved in Amorphous Silicon uncooled microbolometer development since 1992. This silicon IR detection is now well mastered and matured so that industrial transfer of LETI technology was performed in 2000 towards Sofradir. Industrial production of 320 x 240 microbolometer array with 45micrometers pitch is then started. After a description of the technology and the methodology for reliability enhancement, we present the readout circuit architectures designs and its evolution from the 256 x 64 array to the different version of 320 x 240 arrays. Electro-optical results obtained from these IRCMOS are presented. NEDT close to 30 mK is now obtained with our standard microbolometer amorphous silicon technology.

  16. BDDR, a new CEA technological and operating reactor database

    SciTech Connect

    Soldevilla, M.; Salmons, S.; Espinosa, B.

    2013-07-01

    The new application BDDR (Reactor database) has been developed at CEA in order to manage nuclear reactors technological and operating data. This application is a knowledge management tool which meets several internal needs: -) to facilitate scenario studies for any set of reactors, e.g. non-proliferation assessments; -) to make core physics studies easier, whatever the reactor design (PWR-Pressurized Water Reactor-, BWR-Boiling Water Reactor-, MAGNOX- Magnesium Oxide reactor-, CANDU - CANada Deuterium Uranium-, FBR - Fast Breeder Reactor -, etc.); -) to preserve the technological data of all reactors (past and present, power generating or experimental, naval propulsion,...) in a unique repository. Within the application database are enclosed location data and operating history data as well as a tree-like structure containing numerous technological data. These data address all kinds of reactors features and components. A few neutronics data are also included (neutrons fluxes). The BDDR application is based on open-source technologies and thin client/server architecture. The software architecture has been made flexible enough to allow for any change. (authors)

  17. 77 FR 10599 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-22

    ... conducted by the Commission on February 16, 2012; notice of which was published in 77 FR 3321, January 23... COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on March 15, 2012, in...

  18. Comparison of Ablation Predictions for Carbonaceous Materials Using CEA and JANAF-Based Species Thermodynamics

    NASA Technical Reports Server (NTRS)

    Milos, Frank S.

    2011-01-01

    In most previous work at NASA Ames Research Center, ablation predictions for carbonaceous materials were obtained using a species thermodynamics database developed by Aerotherm Corporation. This database is derived mostly from the JANAF thermochemical tables. However, the CEA thermodynamics database, also used by NASA, is considered more up to date. In this work, the FIAT code was modified to use CEA-based curve fits for species thermodynamics, then analyses using both the JANAF and CEA thermodynamics were performed for carbon and carbon phenolic materials over a range of test conditions. The ablation predictions are comparable at lower heat fluxes where the dominant mechanism is carbon oxidation. However, the predictions begin to diverge in the sublimation regime, with the CEA model predicting lower recession. The disagreement is more significant for carbon phenolic than for carbon, and this difference is attributed to hydrocarbon species that may contribute to the ablation rate.

  19. Iodine-131 labeled anti-CEA antibodies uptake by Huerthle cell carcinoma

    SciTech Connect

    Abdel-Nabi, H.; Hinkle, G.H.; Falko, J.M.; Kelly, D.; Olsen, J.O.; Martin, E.W. Jr.

    1985-10-01

    Localization of Huerthle cell cancer deposits in the lung with I-131 labeled anti-carcinoembryonic antigen (CEA) monoclonal antibody is described. This technique may prove useful if conventional scanning with I-131 sodium iodide for distant metastases is negative.

  20. Diagnostic value of mesothelin in pleural fluids: comparison with CYFRA 21-1 and CEA.

    PubMed

    Filiberti, Rosa; Parodi, Stefano; Libener, Roberta; Ivaldi, Giovanni Paolo; Canessa, Pier Aldo; Ugolini, Donatella; Bobbio, Barbara; Marroni, Paola

    2013-06-01

    CYFRA 21-1 and CEA have been applied for the differential diagnosis of malignant pleural mesothelioma (MPM). The soluble mesothelin-related peptide (SMRP) has been proposed as a specific marker for distinguishing MPM from benign diseases and other malignancies in pleural effusions (PEs). In this study, we evaluated the usefulness of SMRP in PEs in the detection of mesotheliomas by comparing it with that of CYFRA 21-1, CEA, and with cytological examination. One hundred and seventy-seven consecutive patients (57 MPM, 64 metastatic tumors, and 56 benign diseases) were evaluated using commercial tests. The performance of the markers was analyzed by standard ROC analysis methods, using the area under a ROC curve (AUC) as a measure of accuracy. CYFRA 21-1 better differentiated malignant from benign effusions. The corresponding area under the receiver operating characteristic curve was 0.87, while it was 0.74 for SMRP and 0.64 for CEA (p < 0.001). Conversely, SMRP differentiated MPM from all other PEs better than both CYFRA 21-1 and CEA (AUC = 0.84, 0.76, and 0.32, respectively, p = 0.003). Low levels of CEA were associated with a MPM diagnosis. The AUC for differentiating MPM from metastases was 0.81 for SMRP, 0.61 for CYFRA 21-1, and 0.20 for CEA (p < 0.001). In cases with negative or suspicious cytology, SMRP and CYFRA 21-1 identified 36/71 and 46/66 malignant PEs (29 and 31 MPM, respectively). Only 1 MPM showed a high CEA concentration. No single marker showed the best performance in any comparison. Results suggest that SMRP could improve CYFRA 21-1 and CEA accuracy in the differential diagnosis of MPM. PMID:23532816

  1. Unusual elevation of CEA in a patient with history of colon cancer.

    PubMed

    Hsu, Tzu-Chi

    2006-12-01

    A 35-year-old female received right hemicolectomy for a poorly differentiated adenocarcinoma of the ascending colon with lymph node metastasis (1/28) in February 1997. CEA was 1.68 ng/microl prior to colectomy. Adjuvant chemotherapy with weekly 5-FU and leucovorin intravenously was started following surgery and discontinued after 17 doses in May 1997. She received bilateral salpingo-ophorecctomy for metastatic cancer in August 1999. Intravenous chemotherapy was resumed with weekly 5-FU and leucovorin intravenously in August 1999. CEA was 93.8 ng/microl in November 1999. Intravenous chemotherapy was discontinued after 20 doses and oral chemotherapy with futraful and leucovorin was started in January 2000. CEA was found to be 240.3 ng/microl in December 1999 and then elevated to 1521.3 ng/microl in June 2001, which was 10 months after resection of metastatic ovarian cancer. No metastatic lesions could be detected, however, with image studies. The CEA decreased to 396.6 ng/microl three months later. Futraful was switched to uracil-tegafur (UFUR) in September 2001. The CEA for the patient ranged from 68.5 to 298.9 ng/microl for the following 5 years without aggressive chemotherapy. No evidence of recurrence could be demonstrated by imaging studies. The patient is not a smoker and denied exposure to a smoking environment. She was also not known to have persistent infections, inflammatory bowel disease, pancreatitis, cirrhosis of the liver, or any benign tumors. The current case suggested that: (i) elevation of CEA is not necessarily well correlated with presence of metastatic colon cancer; (ii) some patients may live with elevated CEA for years without evidence of recurrence or metastasis; (iii) aggressive chemotherapy may not be necessary in patients with only elevated CEA. PMID:17060406

  2. Comparison of the CEAS and Williams-type barley yield models for North Dakota and Minnesota

    NASA Technical Reports Server (NTRS)

    Leduc, S. (Principal Investigator)

    1982-01-01

    The CEAS and Williams type models were compared based on specified selection criteria which includes a ten year bootstrap test (1970-1979). Based on this, the models were quite comparable; however, the CEAS model was slightly better overall. The Williams type model seemed better for the 1974 estimates. Because that year spring wheat yield was particularly low, the Williams type model should not be excluded from further consideration.

  3. Commissioning Experience of SNS

    SciTech Connect

    Plum, Michael A

    2007-07-01

    The Spallation Neutron Source accelerator complex consists of a 2.5 MeV H{sup -} front-end injector system, a 186 MeV normal-conducting linear accelerator, a 1 GeV superconducting linear accelerator, an accumulator ring, and associated beam transport lines. The linac was commissioned in five discrete runs, starting in 2002 and completed in 2005. The accumulator ring and associated beam transport lines were commissioned in two runs in January-February and April 2006. With the completed commissioning of the SNS accelerator, the facility has begun initial low-power operations. In the course of beam commissioning, most beam performance parameters and beam intensity goals have been achieved at low duty factor. A number of beam dynamics measurements have been performed, including emittance evolution, transverse coupling in the ring, beam instability thresholds, and beam distributions on the target. The commissioning results, achieved beam performance and initial operating experience of the SNS linac will be presented.

  4. Commission 42: Close Binaries

    NASA Astrophysics Data System (ADS)

    Giménez, Alvaro; Rucinski, Slavek; Szkody, P.; Gies, D.; Kang, Y.-W.; Linsky, J.; Livio, M.; Morrell, N.; Hilditch, R.; Nordström, B.; Ribas, I.; Sion, E.; Vrielman, S.

    2007-03-01

    The triennial report from Commission 42 covers various topics like massive binaries, contact systems, cataclysmic variables and low-mass binary stars. We try in a number of sections to provide an update on the current status of the main research areas in the field of close binaries. It is not a formal review, even complete or comprehensive, but an attempt to bring the main topics on recent research to astronomers working in other fields. References are also not comprehensive and simply added to the text to help the reader looking for deeper information on the subject. For this reason, we have chosen to include references (sometimes incomplete for ongoing work) not in a list at the end but integrated with the main text body. Complete references and additional sources can be easily obtained through web access of ADS or SIMBAD. Furthermore, the summary of papers on close-binary research contained in the Bibliography of Close Binaries (BCB) can be accessed from the web site of Commission 42. I would like to express the gratitude of the commission for the careful work of Colin Scarfe as Editor-in-Chief of BCB and Andras Holl and Attila Sragli for maintaining the web pages of the Commission within the structure of Division V. Finally, K. Olah and J. Jurcsik are gratefully acknowledged for their continued support as editors of the Information Bulletin on Variable Stars (IBVS), also accessible through the commission web page.

  5. Expression of CEA, CA19-9, CA125, and EpCAM in pseudomyxoma peritonei.

    PubMed

    Nummela, Pirjo; Leinonen, Hannele; Järvinen, Petrus; Thiel, Alexandra; Järvinen, Heikki; Lepistö, Anna; Ristimäki, Ari

    2016-08-01

    Pseudomyxoma peritonei is a fatal clinical syndrome with mucinous tumor cells disseminated into peritoneal cavity and secreting abundant mucinous ascites. The serum tumor markers CEA, CA19-9, and CA125 are used to monitor pseudomyxoma peritonei remission, but their expression at tissue level has not been well characterized. Herein, we analyzed expression of these proteins and the adenocarcinoma marker EpCAM in 92 appendix-derived pseudomyxoma peritonei tumors by immunohistochemistry. All tumors were found to ubiquitously express CEA and EpCAM. In the majority of the tumors (94.6%), CEA showed polarized immunostaining, but in 5 aggressive high-grade tumors containing numerous signet ring cells, a nonpolarized staining was detected. We found preoperative CEA serum values to correlate with peritoneal cancer index. However, the serum values of the advanced cases with nonpolarized staining pattern were normal, and the patients died within 5 years after diagnosis. Thus, serum CEA measurements did not reflect aggressiveness of these tumors. CA19-9 showed strong immunopositivity in most of the tumors (91.3%), and mutated enzyme FUT3 was demonstrated from the cases showing negative or weak staining. CA125 was infrequently expressed by tumor cells (focal staining in 6.5% of the cases), but in most of the cases (79.3%), adjacent nonneoplastic mesothelial cells showed immunopositivity. As a conclusion, CEA and EpCAM are invariably expressed by pseudomyxoma peritonei tumor cells and could be exploited to targeted therapies against this malignancy. PMID:27038681

  6. Commissioning of CEBAF

    SciTech Connect

    Andrew Hutton

    1994-06-01

    Construction of the CEBAF accelerator, a 4 GeV CW recirculating linac, is virtually complete. The 338 power sources and superconducting RF cavities, which have all run above nominal operating gradient in vertical tests (average 10.7 MeV/m), are installed. All the major components of the nine recirculation arcs are installed and aligned. Pre-commissioning was performed in parallel with construction. Ninety-nine superconducting cavities were operated simultaneously at the nominal gradient of 5 MeV/m. A maximum beam current of 110 PA CW (ZOO PA design) was reached. A cryomodule with eight cavities has operated at 8 MeV/m. Commissioning of the entire machine began in May 94. Results obtained during commissioning of the two linacs and the first arc are presented. 600 MeV beam is ready to be brought to the first experimental hall meeting a DOE milestone established in 1988.

  7. ATF2 Commissioning

    SciTech Connect

    Seryi, A.; Christian, G.; Parker, B.; Schulte, D.; Delahaye, J.-P.; Tomas, R.; Zimmermann, F.; Wolski, A.; Elsen, E.; Sanuki, T.; Gianfelice-Wendt, E.; Ross, M.; Wendt, M.; Takahashi, T.; Bai, S.; Gao, J.; Bolzon, B.; Geffroy, N.; Jeremie, A.; Apsimon, R.; Burrows, P.; /Oxford U., JAI /Kyoto U., Inst. Chem. Res. /Kyungpook Natl. U. /Orsay, LAL /Phang Accelerator Lab /Royal Holloway, U. of London /SLAC /Daresbury /University Coll. London /Manchester U. /Univ. of Tokyo U.

    2009-10-30

    ATF2 is a final-focus test beam line that aims to focus the low-emittance beam from the ATF damping ring to a beam size of about 37 nm, and at the same time to demonstrate nm beam stability, using numerous advanced beam diagnostics and feedback tools. The construction has been finished at the end of 2008 and the beam commissioning of ATF2 has started in December of 2008. ATF2 is constructed and commissioned by ATF international collaborations with strong US, Asian and European participation.

  8. Melanoma cell surface-expressed phosphatidylserine as a therapeutic target for cationic anticancer peptide, temporin-1CEa.

    PubMed

    Wang, Che; Chen, Yin-Wang; Zhang, Liang; Gong, Xian-Ge; Zhou, Yang; Shang, De-Jing

    2016-07-01

    We have previously reported that temporin-1CEa, a cationic antimicrobial peptide, exerts preferential cytotoxicity toward cancer cells. However, the exact molecular mechanism for this cancer-selectivity is still largely unknown. Here, we found that the negatively charged phosphatidylserine (PS) expressed on cancer cell surface serves as a target for temporin-1CEa. Our results indicate that human A375 melanoma cells express 50-fold more PS than non-cancerous HaCaT cells. The expression of cell surface PS in various cancer cell lines closely correlated with their ability to be recognized, bound and killed by temporin-1CEa. Additionally, the cytotoxicity of temporin-1CEa against A375 cells can be ameliorated by annexin V, which binds to cell surface PS with high affinity. Moreover, the data of isothermal titration calorimetry assay further confirmed a direct binding of temporin-1CEa to PS, at a ratio of 1:5 (temporin-1CEa:PS). Interestingly, the circular dichroism spectra analysis using artificial biomembrane revealed that PS not only provides electrostatic attractive sites for temporin-1CEa but also confers the membrane-bound temporin-1CEa to form α-helical structure, therefore, enhances the affinity and membrane disrupting ability of temporin-1CEa. In summary, these findings suggested that the melanoma cells expressed PS may serve as a promising target for temporin-1CEa or other cationic anticancer peptides. PMID:26596643

  9. Conservation Commissions in Massachusetts.

    ERIC Educational Resources Information Center

    Scheffey, Andrew J. W.

    The Conservation Foundation reported on the experience of a resource development specialist in the state of Massachusetts on the public's growing concern for environmental quality. After tracing the origins of the Massachusetts movement, the report draws upon a variety of specific state experiences to illustrate the commission's growing pains and…

  10. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-11-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  11. Nuclear Regulatory Commission Issuances

    SciTech Connect

    Not Available

    1994-10-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors Decisions (DD), and the Denials of Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  12. Nuclear Regulatory Commission issuances

    SciTech Connect

    1997-09-01

    This report includes the issuances received during the specified period from the Commission (CLI), the Atomic Safety and Licensing Boards (LBP), the Administrative Law Judges (ALJ), the Directors` Decisions (DD), and the Decisions on Petitions for Rulemaking (DPRM). The summaries and headnotes preceding the opinions reported herein are not to be deemed a part of those opinions or have any independent legal significance.

  13. SPEAR 3 Commissioning Software

    SciTech Connect

    Corbett, W.J.; Portmann, G.J.; Safranek, J.A.; Terebilo, A.; /SLAC, SSRL

    2005-05-09

    The short SPEAR 3 startup time required precommissioned software for machine setup, beam measurements and data analysis. To accomplish this goal, we used Matlab with the Accelerator Toolbox (AT), the Channel Access Toolbox (MCA) and Middle Layer software to integrate code and streamline production. This paper outlines the software architecture, describes the Middle Layer component and provides examples from SPEAR 3 commissioning.

  14. 77 FR 28420 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-14

    ... the notice for such hearing, which was published in 77 FR 23319, April 18, 2012. Authority: Pub. L. 91... COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on June 7, 2012, in Binghamton,...

  15. 78 FR 52601 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-23

    ... on August 15, 2013, and identified in the notice for such hearing, which was published in 78 FR 43961... COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY: The Susquehanna River Basin Commission will hold its regular business meeting on September 19, 2013, in...

  16. 78 FR 12412 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-02-22

    ... Commission on February 14, 2013, and identified in the notice for such hearing, which was published in 78 FR... From the Federal Register Online via the Government Publishing Office ] SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY:...

  17. 77 FR 70204 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-23

    ... Commission on November 15, 2012, and identified in the notice for such hearing, which was published in 77 FR... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY:...

  18. The value of KRAS mutation testing with CEA for the diagnosis of pancreatic mucinous cysts

    PubMed Central

    Kadayifci, Abdurrahman; Al-Haddad, Mohammad; Atar, Mustafa; Dewitt, John M.; Forcione, David G.; Sherman, Stuart; Casey, Brenna W.; Fernandez-del Castillo, Carlos; Schmidt, C. Max; Pitman, Martha B.; Brugge, William R.

    2016-01-01

    Background and aims: Pancreatic cyst fluid (PCF) CEA has been shown to be the most accurate preoperative test for detection of cystic mucinous neoplasms (CMNs). This study aimed to assess the added value of PCF KRAS mutational analysis to CEA for diagnosis of CMNs. Patients and methods: This is a retrospective study of prospectively collected endoscopic ultrasonography (EUS) fine-needle aspiration (FNA) data. KRAS mutation was determined by direct sequencing or equivalent methods. Cysts were classified histologically (surgical cohort) or by clinical (EUS or FNA) findings (clinical cohort). Performance characteristics of KRAS, CEA and their combination for detection of a cystic mucinous neoplasm (CMN) and malignancy were calculated. Results: The study cohort consisted of 943 patients: 147 in the surgical cohort and 796 in the clinical cohort. Overall, KRAS and CEA each had high specificity (100 % and 93.2 %), but low sensitivity (48.3 % and 56.3 %) for the diagnosis of a CMN. The positivity of KRAS or CEA increased the diagnostic accuracy (80.8 %) and AUC (0.84) significantly compared to KRAS (65.3 % and 0.74) or CEA (65.8 % and 0.74) alone, but only in the clinical cohort (P < 0.0001 for both). KRAS mutation was significantly more frequent in malignant CMNs compared to histologically confirmed non-malignant CMNs (73 % vs. 37 %, P = 0.001). The negative predictive value of KRAS mutation was 77.6 % in differentiating non-malignant cysts. Conclusions: The detection of a KRAS mutation in PCF is a highly specific test for mucinous cysts. It outperforms CEA for sensitivity in mucinous cyst diagnosis, but the data does not support its routine use. PMID:27092317

  19. Commissioning the Majorana Demonstrator

    NASA Astrophysics Data System (ADS)

    Xu, Wenqin; Majorana Collaboration

    2016-03-01

    The Majorana Demonstrator deploys high purity germanium (HPGe) detector modules to search for neutrinoless double beta (0 νββ) decay in 76Ge. The experiment is aimed at demonstrating the technical feasibility and low backgrounds for a next generation Ge-based BBz experiment. The program of testing and commissioning the Demonstrator modules is a critical step to debug and improve the experimental apparatus, to establish and refine operational procedures, and to develop data analysis tools. In this talk, we will discuss our experience commissioning the Demonstrator modules and show how this program leads to successful data-taking. This material is based upon work supported by the U.S. Department of Energy, Office of Science, Office of Nuclear Physics, the Particle Astrophysics and Nuclear Physics Programs of the National Science Foundation, and the Sanford Underground Research Facility.

  20. Correction: AIDS commission.

    PubMed

    1987-11-01

    A recent article by William Booth on the President's AIDS commission (News & Comment, 16 Oct., p. 262) incorrectly states that commission member Cory SerVaas, publisher of the Saturday Evening Post, drives her AIDS Mobile around the country. SerVaas does not drive the traveling van that offers free AIDS testing. Rather, she often flies to meet it as it travels around the country, stopping at shopping malls and churches by prearrangement with local civic and religious groups. SerVaas denies saying that homosexuals are "deviants." "We have helped homosexuals for many years," she says, pointing out that although her group primarily tests people who have a low risk of being infected, such as recipients of blood transfusions and women who may become pregnant, members of high-risk groups such as homosexuals and drug addicts are not excluded. PMID:17814691

  1. Commission 42: Close Binaries

    NASA Astrophysics Data System (ADS)

    Rucinski, Slavek M.; Ribas, Ignasi; Giménez, Alvaro; Harmanec, Petr; Hilditch, Ronald W.; Kaluzny, Janusz; Niarchos, Panayiotis; Nordström, Birgitta; Oláh, Katalin; Richards, Mercedes T.; Scarfe, Colin D.; Sion, Edward M.; Torres, Guillermo; Vrielmann, Sonja

    2010-05-01

    During the commission business session, the past President presented the new Organizing Committee which was selected by the OC through a e-mail vote conducted during the months before the Rio de Janeiro General Assembly. The new OC will consist of Ignasi Ribas (President), Mercedes Richards (Vice President), and Slavek Rucinski (Past President) with the members: David Bradstreet, Petr Harmanec, Janusz Kaluzny, Joanna Mikolajewska, Ulisse Munari, Panos Niarchos, Katalin Olah, Theo Pribulla, Colin Scarfe and Guillermo Torres.

  2. Nuclear Regulatory Commission issuances

    SciTech Connect

    1996-04-01

    This report includes the issuances received during the April 1996 reporting period from the Commission, the Atomic Safety and Licensing Boards, the Administrative Law Judges, the Directors` Decisions, and the Decisions on Petitions for Rulemaking. Included are issuances pertaining to: (1) Yankee Nuclear Power Station, (2) Georgia Tech Research Reactor, (3) River Bend Station, (4) Millstone Unit 1, (5) Thermo-Lag fire barrier material, and (6) Louisiana Energy Services.

  3. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa.

    PubMed

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R

    2016-05-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  4. Uropathogenic E. coli Exploit CEA to Promote Colonization of the Urogenital Tract Mucosa

    PubMed Central

    Muenzner, Petra; Kengmo Tchoupa, Arnaud; Klauser, Benedikt; Brunner, Thomas; Putze, Johannes; Dobrindt, Ulrich; Hauck, Christof R.

    2016-01-01

    Attachment to the host mucosa is a key step in bacterial pathogenesis. On the apical surface of epithelial cells, members of the human carcinoembryonic antigen (CEA) family are abundant glycoproteins involved in cell-cell adhesion and modulation of cell signaling. Interestingly, several gram-negative bacterial pathogens target these receptors by specialized adhesins. The prototype of a CEACAM-binding pathogen, Neisseria gonorrhoeae, utilizes colony opacity associated (Opa) proteins to engage CEA, as well as the CEA-related cell adhesion molecules CEACAM1 and CEACAM6 on human epithelial cells. By heterologous expression of neisserial Opa proteins in non-pathogenic E. coli we find that the Opa protein-CEA interaction is sufficient to alter gene expression, to increase integrin activity and to promote matrix adhesion of infected cervical carcinoma cells and immortalized vaginal epithelial cells in vitro. These CEA-triggered events translate in suppression of exfoliation and improved colonization of the urogenital tract by Opa protein-expressing E. coli in CEA-transgenic compared to wildtype mice. Interestingly, uropathogenic E. coli expressing an unrelated CEACAM-binding protein of the Afa/Dr adhesin family recapitulate the in vitro and in vivo phenotype. In contrast, an isogenic strain lacking the CEACAM-binding adhesin shows reduced colonization and does not suppress epithelial exfoliation. These results demonstrate that engagement of human CEACAMs by distinct bacterial adhesins is sufficient to blunt exfoliation and to promote host infection. Our findings provide novel insight into mucosal colonization by a common UPEC pathotype and help to explain why human CEACAMs are a preferred epithelial target structure for diverse gram-negative bacteria to establish a foothold on the human mucosa. PMID:27171273

  5. Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report

    PubMed Central

    Saif, Muhammad W

    2016-01-01

    Carcinoembryonic antigen (CEA) has been shown to be associated with tumor burden in patients with colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. We report a case of reversible CEA elevation in a patient using lithium for bipolar disorder. A 58-year-old female with a longstanding smoking history and a past medical history of chronic obstructive pulmonary disease (COPD), bipolar illness, hypothyroidism, and obesity was found to have an elevated CEA level of 11.2 ng/ml (normal level <5 ng/ml) in the workup for postmenopausal bleeding. Her history was not positive for malignancy of colorectum, ovaries, thyroid, or breast.  She underwent a large number of imaging and endoscopic studies to evaluate for colorectal, breast, ovarian, and lung cancer; however, it did not reveal any evidence of malignancy. Upon review of her medications, she reported that she had recently started lithium for her bipolar illness. We followed up her CEA level while her dose of lithium was reduced from 450 to 300 mg per day. Her CEA level decreased from 25 mg/dl to 6.1 mg/dl and remained stable over the course of the next eight months. Our case is the first case report that identifies lithium as a potential cause of reversible CEA elevation. The underlying mechanism is yet to be elucidated, but it underscores the importance of investigating the medications as part of the workup. PMID:27446768

  6. Elevated Level of Serum Carcinoembryonic Antigen (CEA) and Search for a Malignancy: A Case Report.

    PubMed

    Asad-Ur-Rahman, Fnu; Saif, Muhammad W

    2016-01-01

    Carcinoembryonic antigen (CEA) has been shown to be associated with tumor burden in patients with colorectal cancer. However, it is also elevated to a significant degree in a number of other malignant and non-malignant conditions. We report a case of reversible CEA elevation in a patient using lithium for bipolar disorder. A 58-year-old female with a longstanding smoking history and a past medical history of chronic obstructive pulmonary disease (COPD), bipolar illness, hypothyroidism, and obesity was found to have an elevated CEA level of 11.2 ng/ml (normal level <5 ng/ml) in the workup for postmenopausal bleeding. Her history was not positive for malignancy of colorectum, ovaries, thyroid, or breast.  She underwent a large number of imaging and endoscopic studies to evaluate for colorectal, breast, ovarian, and lung cancer; however, it did not reveal any evidence of malignancy. Upon review of her medications, she reported that she had recently started lithium for her bipolar illness. We followed up her CEA level while her dose of lithium was reduced from 450 to 300 mg per day. Her CEA level decreased from 25 mg/dl to 6.1 mg/dl and remained stable over the course of the next eight months. Our case is the first case report that identifies lithium as a potential cause of reversible CEA elevation. The underlying mechanism is yet to be elucidated, but it underscores the importance of investigating the medications as part of the workup. PMID:27446768

  7. Securities and Exchange Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... [Securities and Exchange Commission Semiannual Regulatory Agenda ] Part XXIII Securities and Exchange Commission Semiannual Regulatory Agenda ] SECURITIES AND EXCHANGE COMMISSION (SEC) SECURITIES AND EXCHANGE COMMISSION 17 CFR Ch. II Regulatory Flexibility Agenda AGENCY: Securities and Exchange Commission. ACTION: Semiannual regulatory...

  8. Diagnostic value of CEA and CYFRA 21-1 tumor markers in primary lung cancer.

    PubMed

    Okamura, Kyoko; Takayama, Koichi; Izumi, Miiru; Harada, Taishi; Furuyama, Kazuto; Nakanishi, Yoichi

    2013-04-01

    Lung cancer is sometimes difficult to differentiate from benign lung diseases expressing nodular shadow in imaging study. We assessed the diagnostic value of two commonly used tumor markers in distinguishing primary lung cancer from benign lung disease. The serum levels of carcinoembryonic antigen (CEA) and cytokeratin 19 fragments (CYFRA 21-1) were retrospectively analyzed in 655 lung cancer patients and 237 patients with benign lung disease. The standard cut-off levels of 3.2 ng/mL CEA and 3.5 ng/mL CYFRA 21-1 and twice these respective levels (6.4 ng/mL and 7.0 ng/mL) were used. CEA and CYFRA 21-1 levels were elevated in 32% and 11% of benign lung disease patients, respectively. CEA sensitivity and specificity for lung cancer diagnosis was 69% and 68% respectively, while that for CYFRA 21-1 was 43% and 89%, respectively. Thus, the combined value for the specificity of the two tumor markers was greater than either alone. Patients were grouped depending on their hospital status, and prevalence rates were determined. The prevalence rate of lung cancer in admitted patients was 51%, the prevalence rate of lung cancer in outpatients was 12%, and the prevalence rate of lung cancer identified during health check-ups was 0.1%. Positive predictive values (PPVs) were calculated using Bayes' theorem, and varied with the serum tumor marker and prevalence rate: PPVs of CEA [prevalence rate] were 69.2% [51%], 22.7% [12%], and 0.22% [0.1%], while PPVs of CYFRA 21-1 were 80.3% [51%], 34.8% [12%], and 0.39% [0.1%]. However, PPVs for lung cancer diagnosis at a prevalence rate of 51% were 87.3% or higher when the patient exhibited positive CEA and CYFRA 21-1, or CEA or CYFRA 21-1 levels twice the standard cut-off. Our results indicate that CEA and CYFRA 21-1 are reliable serum tumor markers for the diagnosis of lung cancer in addition to CT scans when combined or used individually at twice the standard cut-off level in high prevalence rate groups. The prevalence rate should

  9. Latest pixel size reduction of uncooled IR-FPA at CEA, LETI

    NASA Astrophysics Data System (ADS)

    Becker, Sebastien; Imperinetti, Pierre; Yon, Jean-Jacques; Ouvrier-Buffet, Jean-Louis; Goudon, Valérie; Hamelin, Antoine; Vialle, Claire; Arnaud, Agnès.

    2012-10-01

    Recent developments at the Infrared Lab (LIR) of CEA, LETI have been concentrated on the pixel size reduction of uncooled infrared detectors. With the support from French company ULIS, we have successfully demonstrated the technological integration of 12μm pixels on a commercial TV-format read-out circuit (VGA-ROIC) supplied by ULIS. The 12μm pixel has been designed, processed and characterized in CEA, LETI and first results showed exceptional performances. This paper presents the characterization and associated imagery results.

  10. Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Defraigne, Pascale; Manchester, Richard; Matsakis, Demetrios; Petit, Gerard; Hosokawa, Mizuhiko; Leschiutta, Sigfrid; Zhai, Zao-Cheng

    2010-05-01

    Dr R. N. Manchester and Dr M. Hosokawa have been elected as, respectively, the new President and Vice-President of the Commission for the next term, 2009-2012. Concerning the Organizing Committee (OC) Members, we welcome as new members: Felicitas Aris (BIPM, France), Philip Tuckey (LNE-SYRTE, France), Vladimir Zharov (MSU, Russia), and Shougang Zhang (NTSC, China) and we acknowledge the outgoing members: Demetrios Matsakis, Gerard Petit, Mizuhiko Hosokawa, Sigfrid Leschiutta and Zao-Cheng Zhai. P. Defraigne remains on the OC as immediate Past-President.

  11. Nuclear Regulatory Commission information digest

    SciTech Connect

    None,

    1990-03-01

    The Nuclear Regulatory Commission information digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the commission. This is an annual publication for the general use of the NRC Staff and is available to the public. The digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  12. A Guide to Building Commissioning

    SciTech Connect

    Baechler, Michael C.

    2011-09-01

    Commissioning is the process of verifying that a building's heating, ventilation, and air conditioning (HVAC) and lighting systems perform correctly and efficiently. Without commissioning, system and equipment problems can result in higher than necessary utility bills and unexpected and costly equipment repairs. This report reviews the benefits of commissioning, why it is a requirement for Leadership in Energy and Environmental Design (LEED) certification, and why building codes are gradually adopting commissioning activities into code.

  13. 78 FR 32295 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-29

    ... notice for such hearing, which was published in 78 FR 24785, April 26, 2013. Please note that the... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice. SUMMARY:...

  14. Assembly and analysis of cosmid contigs in the CEA-gene family region of human chromosome 19.

    PubMed Central

    Tynan, K; Olsen, A; Trask, B; de Jong, P; Thompson, J; Zimmermann, W; Carrano, A; Mohrenweiser, H

    1992-01-01

    The carcinoembryonic antigen (CEA)-like genes are members of a large gene family which is part of the immunoglobulin superfamily. The CEA family is divided into two major subgroups, the CEA-subgroup and the pregnancy-specific glycoprotein (PSG)-subgroup. In the course of an effort to develop a set of overlapping cosmids spanning human chromosome 19, we identified 245 cosmids in a human chromosome 19 cosmid library (6-7X redundant) by hybridization with an IgC-like domain fragment of the CEA gene. A fluorescence-based restriction enzyme digest fingerprinting strategy was used to assemble 212 probe-positive cosmids, along with 115 additional cosmids from a collection of approximately 8,000 randomly selected cosmids, into five contigs. Two of the contigs contain CEA-subgroup genes while the remaining three contigs contain PSG-subgroup genes. These five contigs range in size from 100 kb to over 300 kb and span an estimated 1 Mb. The CEA-like gene family was determined by fluorescence in situ hybridization to map in the q13.1-q13.2 region of human chromosome 19. Analysis of the two CEA-subgroup contigs provided verification of the contig assembly strategy and insight into the organization of 9 CEA-subgroup genes. PMID:1579453

  15. Quantitative real-time detection of carcinoembryonic antigen (CEA) from pancreatic cyst fluid using 3-D surface molecular imprinting.

    PubMed

    Yu, Yingjie; Zhang, Qi; Buscaglia, Jonathan; Chang, Chung-Chueh; Liu, Ying; Yang, Zhenhua; Guo, Yichen; Wang, Yantian; Levon, Kalle; Rafailovich, Miriam

    2016-07-21

    In this study, a sensitive, yet robust, biosensing system with real-time electrochemical readout was developed. The biosensor system was applied to the detection of carcinoembryonic antigen (CEA), which is a common marker for many cancers such as pancreatic, breast, and colon cancer. Real time detection of CEA during a medical procedure can be used to make critical decisions regarding further surgical intervention. CEA was templated on gold surface (RMS roughness ∼3-4 nm) coated with a hydrophilic self-assembled monolayer (SAM) on the working electrode of an open circuit potentiometric network. The subsequent removal of template CEA makes the biosensor capable of CEA detection based on its specific structure and conformation. The molecular imprinting (MI) biosensor was further calibrated using the potentiometric responses in solutions with known CEA concentrations and a detection limit of 0.5 ng ml(-1) was achieved. Potentiometric sensing was then applied to pancreatic cyst fluid samples obtained from 18 patients when the cyst fluid was also evaluated using ELISA in a certified pathology laboratory. Excellent agreement was obtained between the quantitation of CEA obtained by both the ELISA and MI biosensor detection for CEA. A 3-D MI model, using the natural rms roughness of PVD gold layers, is presented to explain the high degree of sensitivity and linearity observed in those experiments. PMID:27193921

  16. Future of multistate regional commissions

    SciTech Connect

    Newman, M.

    1980-04-01

    Multistate regional commissions in the United States have been used since 1965. The largest program has been that of the Appalachian Regional Commission (ARC). Institutional and financial barriers have been the most difficult problems encountered by the ARC and other programs (such as Title V commissions). Despite the imperfect performance of the existing regional commissions, they offer a demonstration that some improvement in governmental performance can be achieved. There is virtual unanimity among the nation's governors that this is the route for Federal state relations to follow. Also, the commission route is viewed privately as the most socially acceptable means to have a beneficial impact on government performance. (SAC)

  17. Serum CA 242 in pancreatic cancer. Comparison with CA 19-9 and CEA.

    PubMed

    Pezzilli, R; Billi, P; Plate, L; Laudadio, M A; Sprovieri, G

    1995-01-01

    Serum CA 242, CA 19-9 and CEA concentrations were determined in 94 subjects divided into 5 groups: Group 1 consisted of 22 healthy subjects; Group 2 consisted of 40 patients with pancreatic adenocarcinoma; according to Cubilla and Fitzgerald's classification, 11 tumours were Stage I, 4 were Stage II, and 25 were Stage III. Group 3 consisted of 10 chronic pancreatitis patients, group 4 of 10 acute pancreatitis patients, group 5 of 12 patients with nonpancreatic digestive carcinomas. Ten of these 12 patients had distant metastases. The sensitivity of CA 19-9 in the diagnosis of pancreatic cancer was higher than that of CEA and CA 242 (p < 0.05 and p < 0.005, respectively). In Stage I cancer patients the sensitivity of the markers studied was less than 50% (45% for CA 19-9, 18% for CEA, and 9% for CA 242) whereas most of the 25 patients with metastatic tumours of the pancreas had elevated serum levels of all 3 markers. The various combinations of the three markers did not significantly improve the sensitivity in diagnosing pancreatic cancer. No relationship was found between the localization of the tumour and the serum levels of the 3 markers studied. Similarly, no differences were found between patients with cholestasis and those without. The specificity of the 3 markers, evaluated in patients with benign pancreatic diseases, was 100% for CA 242, 90% for CA 199 and 70% for CEA.(ABSTRACT TRUNCATED AT 250 WORDS) PMID:8562994

  18. 77 FR 74283 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ...\\ Clearing Requirement Determination Under Section 2(h) of the CEA; Proposed Rule, 77 FR 47170 (Aug. 7, 2012... to Trade Under Section 2(h)(8) of the Commodity Exchange Act, 76 FR 77728 (Dec. 14, 2011). Clearing... FR 44464 (July 26, 2011); 17 CFR 39.5. The determinations and rules adopted in this release...

  19. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... experiment design, data analysis, and data management support to project managers and produces merged... key role in the Global Atmospheric Research Program (GARP) experiments). (7) CEAS provides special... global oceanographic data base from observations taken during the First GARP Global Experiment (FGGE)....

  20. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... experiment design, data analysis, and data management support to project managers and produces merged... key role in the Global Atmospheric Research Program (GARP) experiments). (7) CEAS provides special... global oceanographic data base from observations taken during the First GARP Global Experiment (FGGE)....

  1. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... experiment design, data analysis, and data management support to project managers and produces merged... key role in the Global Atmospheric Research Program (GARP) experiments). (7) CEAS provides special... global oceanographic data base from observations taken during the First GARP Global Experiment (FGGE)....

  2. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... experiment design, data analysis, and data management support to project managers and produces merged... key role in the Global Atmospheric Research Program (GARP) experiments). (7) CEAS provides special... global oceanographic data base from observations taken during the First GARP Global Experiment (FGGE)....

  3. 15 CFR 950.7 - Center for Environmental Assessment Services (CEAS).

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... experiment design, data analysis, and data management support to project managers and produces merged... key role in the Global Atmospheric Research Program (GARP) experiments). (7) CEAS provides special... global oceanographic data base from observations taken during the First GARP Global Experiment (FGGE)....

  4. Spanish Pre-University Students' Use of English: CEA Results from the University Entrance Examination

    ERIC Educational Resources Information Center

    Diez-Bedmar, Maria Belen

    2011-01-01

    In this paper an updated overview of the main errors that Spanish students make when writing the English exam in the University Entrance Examination is provided. To do so, a Computer-aided Error Analysis (CEA) (Dagneaux, Denness & Granger, 1998) was conducted on a representative sample of the students who took the exam in June 2008 in Jaen, and…

  5. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas

    PubMed Central

    Jogunoori, Wilma; Menon, Vipin; Majumdar, Avijit; Chen, Jiun-Sheng; Gi, Young Jin; Jeong, Yun Seong; Phan, Liem; Belkin, Mitchell; Gu, Shoujun; Kundra, Suchin; Mistry, Nipun A.; Zhang, Jianping; Su, Xiaoping; Li, Shulin; Lin, Sue-Hwa; Javle, Milind; McMurray, John S.; Rahlfs, Thomas F.; Mishra, Bibhuti; White, Jon; Rashid, Asif; Beauchemin, Nicole; Weston, Brian R.; Shafi, Mehnaz A.; Stroehlein, John R.; Davila, Marta; Akbani, Rehan; Weinstein, John N.; Wu, Xifeng; Mishra, Lopa

    2016-01-01

    Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS) analysis in 2 of 4 pairs of benign colorectal adenoma tissue samples. Unsupervised hierarchical clustered transcriptomic analysis of a further 7 pairs of adenomas reveals distinct mutational signatures regardless of adenoma size. Transitional single nucleotide substitutions of C:G>T:A predominate in the adenoma mutational spectrum. Strikingly, we observe mutations in the TGF-β pathway and CEA-associated genes in 4 out of 11 adenomas, overlapping with the Wnt pathway. Immunohistochemical labeling reveals a nearly 5-fold increase in CEA levels in 23% of adenoma samples with a concomitant loss of TGF-β signaling. We also define a functional role by which the CEA B3 domain interacts with TGFBR1, potentially inactivating the tumor suppressor function of TGF-β signaling. Our study uncovers diverse mutational processes underlying the transition from early adenoma to cancer. This has broad implications for biomarker-driven targeting of CEA/TGF-β in high-risk adenomas and may lead to early detection of aggressive adenoma to CRC progression. PMID:27100181

  6. Environmental Profiles of Paper vs. Electronic UC-CEAS Annual Reports

    EPA Science Inventory

    In 2010, the University of Cincinnati College of Engineering and Applied Sciences (UC-CEAS) created a new electronic format for the Annual Report that could be distributed through the college’s website to replace the prior print version. In order to determine the environmental co...

  7. 77 FR 47169 - Clearing Requirement Determination Under Section 2(h) of the CEA

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... Commodity Exchange Act, 76 FR 77728 (Dec. 14, 2011). Clearing is at the heart of the Dodd-Frank financial...; and (4) the staying of a clearing requirement. \\19\\ See 76 FR 44464 (July 26, 2011); 17 CFR 39.5. This... under Section 2(h) of the CEA, 76 FR 58186 (Sept. 20, 2011). This comment letter is available on...

  8. Mutational Profiles Reveal an Aberrant TGF-β-CEA Regulated Pathway in Colon Adenomas.

    PubMed

    Chen, Jian; Raju, Gottumukkala S; Jogunoori, Wilma; Menon, Vipin; Majumdar, Avijit; Chen, Jiun-Sheng; Gi, Young Jin; Jeong, Yun Seong; Phan, Liem; Belkin, Mitchell; Gu, Shoujun; Kundra, Suchin; Mistry, Nipun A; Zhang, Jianping; Su, Xiaoping; Li, Shulin; Lin, Sue-Hwa; Javle, Milind; McMurray, John S; Rahlfs, Thomas F; Mishra, Bibhuti; White, Jon; Rashid, Asif; Beauchemin, Nicole; Weston, Brian R; Shafi, Mehnaz A; Stroehlein, John R; Davila, Marta; Akbani, Rehan; Weinstein, John N; Wu, Xifeng; Mishra, Lopa

    2016-01-01

    Mutational processes and signatures that drive early tumorigenesis are centrally important for early cancer prevention. Yet, to date, biomarkers and risk factors for polyps (adenomas) that inordinately and rapidly develop into colon cancer remain poorly defined. Here, we describe surprisingly high mutational profiles through whole-genome sequence (WGS) analysis in 2 of 4 pairs of benign colorectal adenoma tissue samples. Unsupervised hierarchical clustered transcriptomic analysis of a further 7 pairs of adenomas reveals distinct mutational signatures regardless of adenoma size. Transitional single nucleotide substitutions of C:G>T:A predominate in the adenoma mutational spectrum. Strikingly, we observe mutations in the TGF-β pathway and CEA-associated genes in 4 out of 11 adenomas, overlapping with the Wnt pathway. Immunohistochemical labeling reveals a nearly 5-fold increase in CEA levels in 23% of adenoma samples with a concomitant loss of TGF-β signaling. We also define a functional role by which the CEA B3 domain interacts with TGFBR1, potentially inactivating the tumor suppressor function of TGF-β signaling. Our study uncovers diverse mutational processes underlying the transition from early adenoma to cancer. This has broad implications for biomarker-driven targeting of CEA/TGF-β in high-risk adenomas and may lead to early detection of aggressive adenoma to CRC progression. PMID:27100181

  9. Commission 10: Solar Activity

    NASA Astrophysics Data System (ADS)

    Klimchuk, James A.; van Driel-Gesztelyi, Lidia; Schrijver, Carolus J.; Melrose, Donald B.; Fletcher, Lyndsay; Gopalswamy, Natchimuthuk; Harrison, Richard A.; Mandrini, Cristina H.; Peter, Hardi; Tsuneta, Saku; Vršnak, Bojan; Wang, Jing-Xiu

    Commission 10 deals with solar activity in all of its forms, ranging from the smallest nanoflares to the largest coronal mass ejections. This report reviews scientific progress over the roughly two-year period ending in the middle of 2008. This has been an exciting time in solar physics, highlighted by the launches of the Hinode and STEREO missions late in 2006. The report is reasonably comprehensive, though it is far from exhaustive. Limited space prevents the inclusion of many significant results. The report is divided into the following sections: Photosphere and chromosphere; Transition region; Corona and coronal heating; Coronal jets; flares; Coronal mass ejection initiation; Global coronal waves and shocks; Coronal dimming; The link between low coronal CME signatures and magnetic clouds; Coronal mass ejections in the heliosphere; and Coronal mass ejections and space weather. Primary authorship is indicated at the beginning of each section.

  10. Commission 10: Solar Activity

    NASA Astrophysics Data System (ADS)

    van Driel-Gesztelyi, Lidia; Schrijver, Carolus J.; Klimchuk, James A.; Charbonneau, Paul; Fletcher, Lyndsay; Hasan, S. Sirajul; Hudson, Hugh S.; Kusano, Kanya; Mandrini, Cristina H.; Peter, Hardi; Vršnak, Bojan; Yan, Yihua

    2012-04-01

    Commission 10 of the International Astronomical Union has more than 650 members who study a wide range of activity phenomena produced by our nearest star, the Sun. Solar activity is intrinsically related to solar magnetic fields and encompasses events from the smallest energy releases (nano- or even picoflares) to the largest eruptions in the Solar System, coronal mass ejections (CMEs), which propagate into the Heliosphere reaching the Earth and beyond. Solar activity is manifested in the appearance of sunspot groups or active regions, which are the principal sources of activity phenomena from the emergence of their magnetic flux through their dispersion and decay. The period 2008-2009 saw an unanticipated extended solar cycle minimum and unprecedentedly weak polar-cap and heliospheric field. Associated with that was the 2009 historical maximum in galactic cosmic rays flux since measurements begun in the middle of the 20th Century. Since then Cycle 24 has re-started solar activity producing some spectacular eruptions observed with a fleet of spacecraft and ground-based facilities. In the last triennium major advances in our knowledge and understanding of solar activity were due to continuing success of space missions as SOHO, Hinode, RHESSI and the twin STEREO spacecraft, further enriched by the breathtaking images of the solar atmosphere produced by the Solar Dynamic Observatory (SDO) launched on 11 February 2010 in the framework of NASA's Living with a Star program. In August 2012, at the time of the IAU General Assembly in Beijing when the mandate of this Commission ends, we will be in the unique position to have for the first time a full 3-D view of the Sun and solar activity phenomena provided by the twin STEREO missions about 120 degrees behind and ahead of Earth and other spacecraft around the Earth and ground-based observatories. These new observational insights are continuously posing new questions, inspiring and advancing theoretical analysis and

  11. EMACK electromagnetic launcher commissioning

    NASA Astrophysics Data System (ADS)

    Deis, D. W.; Scherbarth, D. W.; Ferrentino, G. L.

    1984-03-01

    The Laboratory Demonstration Electromagnetic Launcher Program (EMACK) was initiated in April 1979, with the objective to design, construct, and demonstrate a complete electromagnetic launcher (EML) system capable of accelerating projectiles of substantial mass to velocities significantly greater than those achievable with conventional chemical systems. The last hardware was installed in late 1981. During February 1982, a series of five test shots was made to evaluate the system's performance. Particular attention is given to the parameters of the final, as-built hardware, and the results of the commissioning tests. The results of these tests have demonstrated the viability of the components required for large scale electromagnetic launchers. It has been shown that large projectiles with velocities significantly greater than those achievable by chemical systems can be accelerated intact.

  12. Commission 45: Spectral Classification

    NASA Astrophysics Data System (ADS)

    Giridhar, Sunetra; Gray, Richard O.; Corbally, Christopher J.; Bailer-Jones, Coryn A. L.; Eyer, Laurent; Irwin, Michael J.; Kirkpatrick, J. Davy; Majewski, Steven; Minniti, Dante; Nordström, Birgitta

    This report gives an update of developments (since the last General Assembly at Prague) in the areas that are of relevance to the commission. In addition to numerous papers, a new monograph entitled Stellar Spectral Classification with Richard Gray and Chris Corbally as leading authors will be published by Princeton University Press as part of their Princeton Series in Astrophysics in April 2009. This book is an up-to-date and encyclopedic review of stellar spectral classification across the H-R diagram, including the traditional MK system in the blue-violet, recent extensions into the ultraviolet and infrared, the newly defined L-type and T-type spectral classes, as well as spectral classification of carbon stars, S-type stars, white dwarfs, novae, supernovae and Wolf-Rayet stars.

  13. MC32 tumor cells acquire Ag-specific CTL resistance through the loss of CEA in a colon cancer model

    PubMed Central

    Lee, Sang-Yeul; Sin, Jeong-Im

    2015-01-01

    We previously reported that MC32 cells resist carcinoembryonic antigen (CEA) DNA vaccination by losing their antigen presentation to Ag-specific CTLs in the context of MHC class I antigens in a colon cancer therapeutic model. In this study, we selected 2 tumor cells, MC32-S2–2 and MC32-S4–2, which have the ability to form tumors in CEA DNA vaccine-immunized mice. Wild type MC32 cells grew significantly less in CEA-immunized mice (with Ag-specific CTL lytic activity) than in control mice (with no Ag-specific CTL lytic activity). However, MC32-S2–2 and MC32-S4–2 cells grew at a similar rate in both control and CEA-immunized mice, confirming their resistant status against CEA DNA vaccination. MC32-S2–2 and MC32-S4–2 cells were not susceptible to lysis by CEA-specific CD8+ T cells. Moreover, when MC32-S2–2 and MC32-S4–2 cells were used as stimulating agents of CEA-specific immune cells for IFN-γ production, these cells failed to stimulate the induction of Ag-specific IFN-γ, suggesting a loss of tumor cell recognition by Ag-specific immune cells. However, MC32-S2–2 and MC32-S4–2 cells expressed MHC class I antigens in a manner similar to that of wild type MC32 cells. Finally, Western blot assay confirmed that in MC32-S2–2 and MC32-S4–2 cells, CEA expression remained absent but mouse CEA was expressed. Taken together, these data show that MC32 cells may also be able to achieve resistance to CEA-specific CTLs by antigen loss in this model. PMID:25902414

  14. Treatment of Uranium Slugs at the CEA Marcoule site - 12026

    SciTech Connect

    Boya, Didier; Fourquet, Line

    2012-07-01

    The decladding units on the Marcoule nuclear site in southeast France were commissioned in the early 1960's to receive spent fuel cartridge for interim storage in pools and to prepare them for dissolution. After decladding, the uranium slugs were sent to the reprocessing plant for dissolution. The units were shut down in 1997. All the operational and process equipment was dismantled and transferred to the ANDRA waste repository between 1998 and 2001. During cleanup of the G2-G3 interim storage pool all the internal components (baskets and machinery) mounted on the civil engineering structures were cut up. In November 2007, a UNGG fuel slug in its aluminum cartridge was found at the bottom of the pool. Similarly, while iron slugs (used to control plutonium-producing reactors) were being sorted, five de-cladded uranium slugs were found between 2006 and 2008. As the processing facilities had already been dismantled, it was decided to send these fuel cartridges to a laboratory for dissolution. The project was to recover and condition the cartridge and slugs and transport them safely to the laboratory. This required the design of dedicated equipment due in particular to the high dose rate and pyro-phoricity hazard. The procedure also required safety clearance by the regulatory authorities for the operations within the facility and for the transport of radioactive materials. The cartridge was dissolved in May 2009, 18 months after it was discovered. Based on the experience acquired, the retrieval of the uranium slugs was completed in March 2011 after a year of preparation. (authors)

  15. Dispersion of Radionuclides and Exposure Assessment in Urban Environments: A Joint CEA and LLNL Report

    SciTech Connect

    Glascoe, Lee; Gowardhan, Akshay; Lennox, Kristin; Simpson, Matthew; Yu, Kristen; Armand, Patrick; Duchenne, Christophe; Mariotte, Frederic; Pectorin, Xavier

    2014-12-19

    In the interest of promoting the international exchange of technical expertise, the US Department of Energy’s Office of Emergency Operations (NA-40) and the French Commissariat à l'Energie Atomique et aux énergies alternatives (CEA) requested that the National Atmospheric Release Advisory Center (NARAC) of Lawrence Livermore National Laboratory (LLNL) in Livermore, California host a joint table top exercise with experts in emergency management and atmospheric transport modeling. In this table top exercise, LLNL and CEA compared each other’s flow and dispersion models. The goal of the comparison is to facilitate the exchange of knowledge, capabilities, and practices, and to demonstrate the utility of modeling dispersal at different levels of computational fidelity. Two modeling approaches were examined, a regional scale modeling approach, appropriate for simple terrain and/or very large releases, and an urban scale modeling approach, appropriate for small releases in a city environment. This report is a summary of LLNL and CEA modeling efforts from this exercise. Two different types of LLNL and CEA models were employed in the analysis: urban-scale models (Aeolus CFD at LLNL/NARAC and Parallel- Micro-SWIFT-SPRAY, PMSS, at CEA) for analysis of a 5,000 Ci radiological release and Lagrangian Particle Dispersion Models (LODI at LLNL/NARAC and PSPRAY at CEA) for analysis of a much larger (500,000 Ci) regional radiological release. Two densely-populated urban locations were chosen: Chicago with its high-rise skyline and gridded street network and Paris with its more consistent, lower building height and complex unaligned street network. Each location was considered under early summer daytime and nighttime conditions. Different levels of fidelity were chosen for each scale: (1) lower fidelity mass-consistent diagnostic, intermediate fidelity Navier-Stokes RANS models, and higher fidelity Navier-Stokes LES for urban-scale analysis, and (2) lower-fidelity single

  16. Variation of uptake of anti-CEA monoclonal antibody with tumor type and mass

    SciTech Connect

    Williams, L.E.; Philben, V.J.; Jakowatz, J.G.; Beatty, B.G.; Vlahos, W.G.; Paxton, R.J.; Shively, J.E.; Beatty, J.D.

    1985-05-01

    A nude mouse model xenografted with 3 human tumor (T) was studied with an anti-carcinoembryonic (..cap alpha..-CEA) monoclonal antibody (MoAb). The MoAb was labeled with In-111 using a bi-functional chelation technique. In vitro cross-reactivity with human blood (B) and liver (L) cells was minimal. Human colon tumors were WIDR, SW403 an LS174T. The murine carcinoma EMT6 was used as a control. In all cases only 62.5 ngm of ..cap alpha..-CEA charged at 10 ..mu..Ci/..mu..gm was given to each animal. The corresponding value in humans, 200 ..mu..gm, is probably subimmunogenic. Organ distribution in percent injected dose/gm (% ID/gm) and images were obtained at 48 h post-injection of the MoAb. CEA levels (mgm/gm of T) were measured for each tumor using the same MoAb (T 84.66). Variation of % ID/gm with LS174T mass (m) was also determined. Uptake by EMT6 was 2.4 +- 0.2 % ID/gm. LS174T uptake varied approximately as the inverse of tumor mass. The authors conclude that tumor accumulation of ..cap alpha..-CEA MoAb is not directly correlated with the amount of CEA in the lesion. The best uptake, T/B and T/L values occurred with LS174T; this was also borne out by the 48 h images. Because of the smaller average SW403 mass, this result cannot readily be explained as a tumor size effect.

  17. Hookah smoking and cancer: carcinoembryonic antigen (CEA) levels in exclusive/ever hookah smokers

    PubMed Central

    Sajid, Khan Mohammad; Chaouachi, Kamal; Mahmood, Rubaida

    2008-01-01

    Background We have recently published some work on CEA levels in hookah (also called narghile, shisha elsewhere) and cigarette smokers. Hookah smokers had higher levels of CEA than non-smokers although mean levels were low compared to cigarette smokers. However some of them were also users of other tobacco products (cigarettes, bidis, etc.). Objectives To find serum CEA levels in ever/exclusive hookah smokers, i.e. those who smoked only hookah (no cigarettes, bidis, etc.), prepared between 1 and 4 times a day with a quantity of up to 120 g of a tobacco-molasses mixture each (i.e. the tobacco weight equivalent of up to 60 cigarettes of 1 g each) and consumed in 1 to 8 sessions. Methods Enhanced chemiluminescent immunometric technique was applied to measure CEA levels in serum samples from 59 exclusive male smokers with age ranging from 20–80 years (mean = 58.8 ± 14.7 years) and 8–65 years of smoking (mean = 37.7 ± 16.8). 36 non-smokers served as controls. Subjects were divided into 3 groups according to the number of preparations; the number of sessions and the total daily smoking time: Light (1; 1; ≤ 20 minutes); Medium (1–3; 1–3; >20 min to ≤ 2 hrs) and Heavy smokers (2–4; 3–8; >2 hrs to ≤ 6 hrs). Because of the nature of distribution of CEA levels among our individuals, Wilcoxon's rank sum two-sample test was applied to compare the variables. Results The overall CEA levels in exclusive hookah smokers (mean: 3.58 ± 2.61 ng/ml; n = 59) were not significantly different (p ≤ 0.0937) from the levels in non-smokers (2.35 ± 0.71 ng/ml). Mean levels in light, medium and heavy smokers were: 1.06 ± 0.492 ng/ml (n = 5); 2.52 ± 1.15 ng/ml (n = 28) and 5.11 ± 3.08 ng/ml (n = 26) respectively. The levels in medium smokers and non-smokers were also not significantly different (p ≤ 0.9138). In heavy smokers, the CEA levels were significantly higher than in non-smokers (p ≤ 0.0001567). Conclusion Overall CEA levels in exclusive hookah smokers were

  18. Joint Commission on rock properties

    NASA Astrophysics Data System (ADS)

    A joint commission on Rock Properties for Petroleum Engineers (RPPE) has been established by the International Society of Rock Mechanics and the Society of Petroleum Engineers to set up data banks on the properties of sedimentary rocks encountered during drilling. Computer-based data banks of complete rock properties will be organized for sandstones (GRESA), shales (ARSHA) and carbonates (CARCA). The commission hopes to access data sources from members of the commission, private companies and the public domain.

  19. ALICE TPC commissioning results

    NASA Astrophysics Data System (ADS)

    Larsen, D. T.; Alice Tpc Collaboration

    2010-05-01

    ALICE is a dedicated heavy-ion experiment at CERN LHC aiming to study the properties of the quark-gluon plasma. A lead-lead collision might produce several 10 00 new particles. Detailed study of the event requires precise measurements of the particle tracks. A 90 m3 Time Projection Chamber (TPC) with more than 500 000 read-out pads was built as the main central barrel tracker. Collisions can be recorded at a rate of up to about 1 kHz. The front-end electronics, designed from FPGAs and custom ASICs, performs shaping, amplification, digitisation and digital filtering of the signals. The data are forwarded to DAQ via 216 1.25 Gb/s fibre-optical links. Configuration, control and monitoring is done by an embedded Linux system on the front-end electronics. Before production runs with beam, extensive commissioning using tracks from cosmics and from the laser system as well as clusters from radioactive krypton gas is needed. Extensive results have been obtained with respect to the performance of the TPC including its sub-systems.

  20. National Knowledge Commission

    NASA Astrophysics Data System (ADS)

    Pitroda, Sam

    2007-04-01

    India's National Knowledge Commission (NKC) established by the prime minister is focused on building institutions and infrastructure in Education, Science and Technology, Innovation etc. to meet the challenges of the knowledge economy in the 21st century and increase India's competitive advantage in the global market. India today stands poised to reap the benefits of a rapidly growing economy and a major demographic advantage, with 550 million young people below the age of 25 years, the largest in the world. The NKC is focused on five critical areas of knowledge related to access, concepts, creation, applications and services. This includes a variety of subject areas such as language, translations, libraries, networks, portals, affirmative action, distance learning, intellectual property, Entrepreneurship, application in Agriculture, health, small and medium scale industries, e-governance etc. One of the keys to this effort is to build a national broadband gigabit of networks of 500 nodes to connect universities, Libraries, Laboratories, Hospitals, Agriculture institutions etc. to share resources and collaborate on multidisciplinary activities. This presentation will introduce the NKC, discuss methodology, subject areas, specific recommendation and outline a plan to build knowledge networks and specifics on network architecture, applications, and utilities.

  1. Ozone transport commission developments

    SciTech Connect

    Joyce, K.M.

    1995-08-01

    On September 27, 1994, the states of the Ozone Transport Commission (OTC) signed an important memorandum of understanding (MOU) agreeing to develop a regional strategy for controlling stationary sources of nitrogen oxide emissions. Specifically, the states of the Ozone Transport Region, OTR, agreed to propose regulations for the control of NOx emissions from boilers and other indirect heat exchangers with a maximum gross heat input rate of at least 250 million BTU per hour. The Ozone Transport Region was divided into Inner, Outer and Northern Zones. States in the Outer Zone agreed to reduce NOx emissions by 55%. States in the Inner Zone agreed to reduce NOx emissions 65%. Facilities in both zones have the option to emit NOx at a rate no greater than 0.2 pounds per million Btu by May 1, 1999. This option provides fairness for the gas-fired plants which already have relatively low NOx emissions. Additionally, States in the Inner and Outer Zones agreed to reduce their NOx emissions by 75% or to emit NOx at a rate no greater than 0.15 pounds per million BTU by May 1, 2003. The Northern Zone States agree to reduce their rate of NOx emissions by 55% from base year levels by May 1, 2003, or to emit NOx at a rate no greater than 0.2 pounds per million BTU. As part of this MOU, States also agreed to develop a regionwide trading mechanism to provide a cost-effective mechanism for implementing the reductions.

  2. Commissioning of NSLS-II

    SciTech Connect

    Willeke, F.

    2015-05-03

    NSLS-II, the new 3rd generation light source at BNL was designed for a brightness of 1022 photons s-1mm-2mrad-2 (0.1%BW)-1. It was constructed between 2009 and 2014. The storage ring was commissioned in April 2014 which was followed by insertion device and beamline commissioning in the fall of 2014. All ambitious design parameters of the facility have already been achieved except for commissioning the full beam intensity of 500mA which requires more RF installation. This paper reports on the results of commissioning.

  3. Model Commissioning Plan and Guide Specifications

    SciTech Connect

    1997-03-01

    The objectives of Model Commissioning Plan and Guide Specifications are to ensure that the design team applies commissioning concepts to the design and prepares commissioning specifications and a commission plan for inclusion in the bid construction documents.

  4. 76 FR 24081 - Notice of Commission Determination

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-04-29

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Notice of Commission Determination AGENCY: Susquehanna River Basin Commission. ACTION: Notice of commission determination. SUMMARY: Pursuant to authority set forth in the Susquehanna River Basin...

  5. Post Commission Final Draft: Recommendations of Interest to Commission.

    ERIC Educational Resources Information Center

    California State Postsecondary Education Commission, Sacramento.

    A brief overview is presented by a blue ribbon commission on the organization of elementary/secondary education and higher education in California, funding provided to community colleges, and recommendations of the California Postsecondary Education Commission regarding postsecondary education. In addition, an outline of issues facing…

  6. Value of human chorionic gonadotropin compared to CEA in discriminating benign from malignant effusions.

    PubMed

    Lamerz, R; Stoetzer, O J; Mezger, J; Brandt, A; Darsow, M; Wilmanns, W

    1999-01-01

    Human chorionic gonadotropin (HCG) is expressed in germ cell tumors and urothelial, breast, lung and colon cancers. The aim of the study was to investigate if the determination of HCG in comparison with CEA is able to discriminate between malignant and benign effusions. Effusion and partially serum samples of 61 patients with benign (g.i., heart/kidney isnuff.) and 116 patients with malignant diseases (g.i., gynec., lung, misc., CUP) were investigated. HCG was specifically determined by an IRMA using 2 monoclonal antibodies, CEA by a conventional double Ab RIA. Cytological staining was preformed using the Pappenheim-method on cytospin preparations. Significant differences (p < 0.001) were found for HCG between benign and malignant ascitic effusions with the best discrimination at 5 IU/l (ROC) and an overall sensitivity of 31.3% (spec. vs benign eff. 93.4%) increasing in subgroups from hematol. (5.8%) < misc. (31.3%) < gynec. (32.1%) < g.i. (36%) < lung (38.1%) to CUP (50%). CEA also showed significant differences between benign and malignant total and ascitic effusions, and weaker for the pleural subgroup (cutoff 9 ng/ml) with a total sensitivity of 44.6% (sp = 100%) increasing from misc. (30.8%) < lung (47.1%) < CUP (50%) < gynec. (60%) < g.i. (60.9%). Comparative cytology and TM determinations increased the positiverate of cytology (45.2%) to 58.3% for either cytology or HCG positive cases, or to 61.6% for either cytology or CEA positive cases. For the combined determination of cytologoy and HCG and CEA, the overall TM positive rate for 33 cytology-pos. cases was 78.8%, but in 40 cytology-negative cases 37.5% for TM positive cases. In conclusion HCG is useful in ascitic > pleural effusions with high specificity (90% at 5 IU/l) but low sensitivity of 31% increasing in g.i., lung and gynecologic cases, CEA a more general TM with higher sensitivity of 45% increasing in g.i., gynecologic and lung cases (sp. 100% at 9 ng/ml) both adding significantly to cytology

  7. CEA serum level as early predictive marker of outcome during EGFR-TKI therapy in advanced NSCLC patients.

    PubMed

    Facchinetti, Francesco; Aldigeri, Raffaella; Aloe, Rosalia; Bortesi, Beatrice; Ardizzoni, Andrea; Tiseo, Marcello

    2015-08-01

    Considering the role of carcinoembryonic antigen (CEA) serum levels as potential useful predictive marker during chemotherapy treatment, we studied its applicability in advanced non-small cell lung cancer (NSCLC) patients treated with epidermal growth factor receptor (EGFR) tyrosine-kinase inhibitors (TKIs). Our retrospective cohort consists of 79 patients (33 EGFR mutated and 46 EGFR wild type or unknown) affected by advanced NSCLC, for whom CEA serum values at the beginning of TKI therapy and after the first month of treatment were available, regardless of treatment line. Baseline CEA value, percentage of CEA reduction after 1 month, and percentage of patients with ≥20 % CEA decrease after 1 month (CEA response) were correlated with disease control rate (DCR), progression-free (PFS), and overall (OS) survival, according to EGFR mutational status. Median baseline CEA levels were significantly higher in EGFR mutated (40.9 ng/ml; interquartile range (IQR) 8.9-197.6) than in wild-type cases (6.2 ng/ml; IQR 2.8-12.8; p = 0.003). Both percentage reduction in CEA levels (-10.7 vs. +13.4 %) and percentage of cases with CEA response (42 vs. 20 %) were significantly higher in mutated vs. wild-type/unknown patients (p = 0.007 and p = 0.027, respectively). In wild-type/unknown patients, CEA response was significantly correlated with DCR (p = 0.001) and resulted as a significant predictor of PFS both in univariate (p = 0.002) and in multivariate analyses (hazard ratio (HR) 0.27; 95 % confidence interval (CI) 0.11-0.66; p = 0.004); only a trend was found for OS prediction (p = 0.082). In EGFR-mutated group, CEA reduction did not show any correlation either with PFS or OS. CEA response after 1 month of EGFR-TKI therapy could be a useful marker, worthy to further studies, as early predictor of treatment outcome in EGFR wild-type/unknown unselected NSCLC cases for which no molecular predictor is yet available. PMID:25731731

  8. Vermont Technical Education Commission Report.

    ERIC Educational Resources Information Center

    Vermont State Technical Education Commission, Montpelier.

    A 1968 New England Regional Commission grant to the Vermont Department of Administration financed a feasibility study for a technical college at the postsecondary level. The commission undertook two specific studies: an examination of ultimate career destinations of Vermont secondary students and a survey of Vermont industry to determine immediate…

  9. Reflections on the Gordon Commission

    ERIC Educational Resources Information Center

    Haertel, Edward

    2014-01-01

    Background:This brief reflection on the work of the Gordon Commission calls out significant themes and implications found in the various papers authored by the commissioners and other scholars, especially those included in this special issue of Teachers College Record. Purpose: The forward-looking vision of the Gordon Commission is contrasted with…

  10. Illinois State Scholarship Commission Report.

    ERIC Educational Resources Information Center

    Illinois State Scholarship Commission, Deerfield.

    The Illinois State Scholarship Commission (ISSC) is responsible for the administration of 9 state authorized and funded financial aid programs for Illinois postsecondary students. The major programs consist of: (1) nonrepayable monetary awards, and (2) guaranteed educational loans. The purposes of the Commission's programs are to: (1) equalize…

  11. C.-E.A. Winslow Day: Proceedings of the June 3, 1977 Centenary Celebration

    PubMed Central

    Viseltear, Arthur J.

    1977-01-01

    Sponsored by Yale University, the City of New Haven, and the John B. Pierce Foundation, the C.-E.A. Winslow Day program consisted of speeches by Mr. Leonard Woodcock, President Emeritus, U.A.W., the Honorable Kenneth Gibson, Mayor of Newark, and Dr. Hector Acuña, Director, Pan American Health Organization; reminiscences of Ira Hiscock, Anna M.R. Lauder Professor Emeritus of Public Health, Mary Elizabeth Tennant, Associate Professor Emeritus of Nursing (Public Health), A. Pharo Gagge, Emeritus Fellow, John B. Pierce Foundation, and Mrs. Harriet Welch, Former President of the VNA of New Haven. The proceedings also included the presentation of gifts and the official C.-E.A. Winslow Day Proclamation. PMID:345631

  12. Thermal hydraulic characteristics study of prototype NET and CEA cable-in-conduit conductors (CICCs)

    SciTech Connect

    Maekawa, Ryuji

    1995-10-31

    The thermal hydraulic characteristics of low temperature helium in a Cable-in-Conduit Conductor (CICC) significantly affects the overall design and performance of the associated large scale superconducting magnet system. It is essential to understand the transient and steady state behavior of the helium in the conductor. Throughout the development of CICCs, the reduction of flow impedance has been one of the key factors to improving the overall pressure drop. The newly developed CICC for the ITER project has a hybrid cooling scheme: a central channel that is surrounded by bundles, for which the thermal hydraulic characteristics are not well understood. This thesis describes an experimental and analytical investigation of thermal hydraulic characteristics of low temperature helium in conventional and hybrid CICCS. Pressure drop measurements for both NET and CEA conductors have been conducted, using low temperature helium and liquid nitrogen to obtain a range of Reynolds numbers. The results are correlated with classical friction factor and Reynolds number analysis. The flow impedance reduction of the CEA conductor is described by measures of a developed flow model. Thermally induced flow in the CEA conductor has been studied with an inductive heating method. The induced velocity in the central channel is measured by a Pitot tube with steady state Reynolds number up to {approximately}7000. The transient pressure wave propagation has been recorded with pressure transducers placed equally along the conductor. The supercritical helium temperature in the central channel has been measured with the thermometer probe. However, the reduction of the central channel area significantly affects the overall thermal hydraulic characteristics of the conductor. The results suggest the importance of the central channel. A transient heat transfer experiment studied the.transverse heat transfer mechanism in the CEA conductor. The temperatures in the central channel and bundle region

  13. Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Matsakis, Demetrios; Defraigne, Pascale; Hosokawa, M.; Leschiutta, S.; Petit, G.; Zhai, Z.-C.

    2007-03-01

    The most intensely discussed and controversial issue in time keeping has been the proposal before the International Telecommunications Union (ITU) to redefine Coordinated Universal Time (UTC) so as to replace leap seconds by leap hours. Should this proposal be adopted, the practice of inserting leap seconds would cease after a specific date. Should the Earth's rotation continue to de-accelerate at its historical rate, the next discontinuity in UTC would be an hour inserted several centuries from now. Advocates of this proposal cite the need to synchronize satellite and other systems, such as GPS, Galileo, and GLONASS, which did not exist and were not envisioned when the current system was adopted. They note that leap second insertions can be and have been incorrectly implemented or accounted for. Such errors have to date had localized impact, but they could cause serious mishaps involving loss of life. For example, some GPS receivers have been known to fail simply because there was no leap second after a long enough interval, other GPS receivers failed because the leap second information was broadcast more than three months in advance, and some commercial software used for internet time-transfer Network Time Protocol (NTP) could either discard all data received after a leap second or interpret it as a frequency change. The ambiguity associated with the extra second could also disrupt financial accounting and certain forms of encryption. Those opposed to the proposal question the need for a change, and also point out the costs of adjusting to the proposed change and its inconvenience to amateur astronomers and others who rely upon astronomical calculations published in advance. Reports have been circulated that the cost of checking and correcting software to accommodate the new definition of UTC would be many millions of dollars for some systems. In October 2005 American Astronomical Society asked the ITU for a year's time to study the issue. This commission has

  14. Colorectal tumors: scintigraphy with In-111 anti-CEA monoclonal antibody and correlation with surgical, histopathologic, and immunohistochemical findings

    SciTech Connect

    Abdel-Nabi, H.H.; Schwartz, A.N.; Goldfogel, G.; Ortman-Nabi, J.A.; Matsuoka, D.M.; Unger, M.W.; Wechter, D.G.

    1988-03-01

    A prospective clinical study of 17 patients with a histologic diagnosis of colorectal carcinoma proved at colonoscopy and surgery was performed with indium-111 anticarcinoembryonic-antigen (CEA) monoclonal antibody (MoAb), ZCE-025. MoAb scanning depicted nine of 16 primary colorectal carcinomas on planar scintigrams (true-positive findings = 56%) and ten of 16 lesions on single-photon emission computed tomography (SPECT) scans (true-positive findings = 62%). Liver metastases were detected in three of three patients, and lymph node metastases were detected in one of four patients. Immunohistochemical examination for CEA in resected colorectal cancer tissues demonstrated a positive correlation between MoAb imaging of primary lesions and cytoplasmic-stromal intracellular CEA distribution. There was no correlation between CEA serum levels and lesion detectability with MoAb scanning.

  15. Synthesis and biological investigations of a ZnPc-antiCEA bioconjugate for imaging of colorectal cancer

    PubMed Central

    Sehgal, Inder; Li, Hairong; Ongarora, Benson; Devillier, Daniel; Vicente, M. Graça H.

    2014-01-01

    Two zinc(II) phthalocyanines (ZnPcs) were conjugated with a monoclonal antibody (MAb) directed against carcinoembryonic antigen (CEA), using an in situ activated carboxylic acid on the ZnPcs. The bioconjugate with the highest ZnPc/MAb ratio of 3 was investigated in vitro for its ability to target and fluorescently label human colorectal HT-29 cells. The ZnPc-CEA MAb 2 was observed to efficiently target HT-29 cells, about 37 times more than unconjugated ZnPc. Furthermore, in the presence of a 4-fold excess of unlabelled anti-CEA antibody, the fluorescence signal of 2 was reduced by ~90% showing that the targeting is CEA-mediated. These studies further confirm the high specificity of Pc-antibody conjugates for antigens over-expressed on tumor cells and warrant further investigations of these immunoconjugates and their derivatives for imaging of colorectal cancer. PMID:25328375

  16. How commissioning affects community nursing.

    PubMed

    Cook, Jane; Horrocks, Susan; Gibbard, Emma; Harland, Lizanne; Wye, Lesley

    Community nurses have direct experience of how changes in the local health economy affect the quality of care patients receive, so it is important that they engage with commissioning to influence decisions made about the quality and direction of their service. This article seeks to demystify commissioning priorities by drawing on findings from a survey of Commissioning for Quality and Innovation indicators for community nursing conducted in England, 2014-15. The article focuses specifically on organisational goals, highlighting the impact of the Francis report and other NHS priorities on quality assessment in community nursing. PMID:26721091

  17. Covalent disulfide-linked anti-CEA diabody allows site-specific conjugation and radiolabeling for tumor targeting applications

    PubMed Central

    Olafsen, Tove; Cheung, Chia-wei; Yazaki, Paul J.; Li, Lin; Sundaresan, Gobalakrishnan; Gambhir, Sanjiv S.; Sherman, Mark A.; Williams, Lawrence E.; Shively, John E.; Raubitschek, Andrew A.; Wu, Anna M.

    2014-01-01

    An engineered anti-carcinoembryonic antigen (CEA) diabody (scFv dimer, 55 kDa) was previously constructed from the murine anti-CEA T84.66 antibody. Tumor targeting, imaging and biodistribution studies in nude mice bearing LS174T xenografts with radiolabeled anti-CEA diabody demonstrated rapid tumor uptake and fast blood clearance, which are favorable properties for an imaging agent. Current radiolabeling approaches result in random modification of the protein surface, which may impair immunoreactivity especially for smaller antibody fragments. Site-specific conjugation approaches can direct modifications to reactive groups located away from the binding site. Here, cysteine residues were introduced into the anti-CEA diabody at three different locations, to provide specific thiol groups for chemical modification. One version (with a C-terminal Gly-Gly-Cys) existed exclusively as a disulfide-bonded dimer. This cysteine-modified diabody (Cys-diabody) retained high binding to CEA and demonstrated tumor targeting and biodistribution properties identical to the non-covalent diabody. Furthermore, following reduction of the disulfide bond, the Cys-diabody could be chemically modified using a thiol-specific bifunctional chelating agent, for radiometal labeling. Thus, the Cys-diabody provides a covalently linked alternative to conventional diabodies, which can be reduced and modified site-specifically. This format will provide a versatile platform for targeting a variety of agents to CEA-positive tumors. PMID:14985534

  18. 77 FR 52106 - Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ...The Susquehanna River Basin Commission will hold its regular business meeting on September 20, 2012, in Harrisburg, Pennsylvania. Details concerning the matters to be addressed at the business meeting are contained in the Supplementary Information section of this...

  19. Wisconsin SRF Electron Gun Commissioning

    SciTech Connect

    Bisognano, Joseph J.; Bissen, M.; Bosch, R.; Efremov, M.; Eisert, D.; Fisher, M.; Green, M.; Jacobs, K.; Keil, R.; Kleman, K.; Rogers, G.; Severson, M.; Yavuz, D. D.; Legg, Robert A.; Bachimanchi, Ramakrishna; Hovater, J. Curtis; Plawski, Tomasz; Powers, Thomas J.

    2013-12-01

    The University of Wisconsin has completed fabrication and commissioning of a low frequency (199.6 MHz) superconducting electron gun based on a quarter wave resonator (QWR) cavity. Its concept was optimized to be the source for a CW free electron laser facility. The gun design includes active tuning and a high temperature superconducting solenoid. We will report on the status of the Wisconsin SRF electron gun program, including commissioning experience and first beam measurements.

  20. 75 FR 48661 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ...The U.S. Secretary of Education (Secretary) announces the establishment of the Equity and Excellence Commission (Equity Commission or Commission). The Federal Advisory Committee Act (FACA) (Pub. L. 92-463, as amended; 5 U.S.C.A., Appendix 2) shall govern the Equity Commission. Purpose: The Secretary is establishing the Commission in order to collect information, analyze issues, and obtain......

  1. 11 CFR 9002.3 - Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Commission. 9002.3 Section 9002.3 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: GENERAL ELECTION FINANCING DEFINITIONS § 9002.3 Commission. Commission means the Federal Election Commission, 999 E Street,...

  2. 11 CFR 9032.3 - Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 11 Federal Elections 1 2010-01-01 2010-01-01 false Commission. 9032.3 Section 9032.3 Federal Elections FEDERAL ELECTION COMMISSION PRESIDENTIAL ELECTION CAMPAIGN FUND: PRESIDENTIAL PRIMARY MATCHING FUND DEFINITIONS § 9032.3 Commission. Commission means the Federal Election Commission, 999 E Street...

  3. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within...

  4. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by...

  5. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 18 Conservation of Power and Water Resources 1 2012-04-01 2012-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within...

  6. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 18 Conservation of Power and Water Resources 1 2010-04-01 2010-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within...

  7. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by...

  8. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 18 Conservation of Power and Water Resources 1 2013-04-01 2013-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within...

  9. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by...

  10. 47 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 1 2011-10-01 2011-10-01 false The Commission. 0.1 Section 0.1 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION Organization General § 0.1 The Commission. The Federal Communications Commission is composed of five (5) members who are appointed by...

  11. 18 CFR 375.101 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 18 Conservation of Power and Water Resources 1 2011-04-01 2011-04-01 false The Commission. 375.101... OF ENERGY REVISED GENERAL RULES THE COMMISSION General Provisions § 375.101 The Commission. (a) Establishment. The Federal Energy Regulatory Commission is an independent regulatory commission within...

  12. AIRIX: an induction accelerator facility developed at CEA for flash radiography in detonics

    NASA Astrophysics Data System (ADS)

    Cavailler, Claude

    1999-06-01

    AIRIX is an induction linear accelerator which will be used for flash radiography in CEA/DAM. Designed to produce an X-ray dose of more than 500 Rads at 1 meter with an X-ray focal spot size diameter of less than 2 mm (LANL-CEA DAM definition), this facility consists in a 4 MeV/3.5 kA pulsed electron injector and 16 MeV induction accelerator powered by 32 high voltage generators. A prototype of this accelerator, called PIVAIR, has been studied and realized in CEA CESTA near Bordeaux. PIVAIR is a validation step for AIRIX at 8 MeV. It includes an injector (4 MeV, 3.5 kA, 60 ns) and 16 inductor cells supplied by 8 high voltage generators (250 kV, 70 ns). Two different technologies of induction cells have been tested (rexolite insulator or ferrite under vacuum). We have chosen ferrite under vacuum cells technology after comparison of results on beam transport and reliability tests. A focusing experiment at 7.2 MeV of the electron beam as been achieved during summer 1997. We have begun to produce X-rays in October 1997. A dose level of 50 Rad at 1 meter has been achieved with an X-ray spot size diameter of 3.5 to 4 mm (LANL-CEA DAM definition). Static flash radiography of very dense object have been achieved from November 97 until February 98. We have been able to test in situ new kinds of very high sensitive X- ray detectors and to check they had reached our very ambitious goals: (1) quantum efficiency at 5 MeV greater than 50% instead of 1% for luminous screens and film; (2) sensitivity less than 10 (mu) Rad (100 time more sensitive than radiographic luminous screens and films); (3) dynamic range greater than 100; (4) resolution less than 2 mm. We will present in this communication brand new kinds of detection systems, called high stopping power detectors, such as: (1) (gamma) camera with segmented thick crystal of BGO and MCP image intensifier; (2) multistep parallel plate avalanche chamber; (3) pixellized CdTe MeV photoconductor matrix. AIRIX accelerator is being

  13. Cold Crucible Induction Melter (CCIM) Demonstration Using a Representative Savannah River Site Sludge Simulant On the Large-Size Pilot Platform at the CEA-Marcoule

    SciTech Connect

    Girold, C.; Delaunay, M.; Dussossoy, J.L.; Lacombe, J.; Iverson, D.; Do Quang, R.; Tchemitcheff, E.; Veyer, C.

    2008-07-01

    The cold-crucible induction melter technology (CCIM) is considered worldwide for industrial implementation to overcome the current limits of high level waste vitrification technologies and to answer future challenges such as: new or difficult sludge compositions, need for improving waste loading, need for high temperatures, and corrosive effluents. More particularly, this technology is being considered for implementation at the US DOE Savannah River site to increase the rate of waste processing while reducing the number of HLW canisters to be produced through increased waste loading and improved waste throughput. A collaborative program involving AREVA, CEA (French Atomic Energy Commission), SRNL (Savannah River National Laboratory) and WSRC (Washington Savannah River Company) has thus been initiated in 2007 to demonstrate vitrification with waste loadings on the order of 50% (versus the current DWPF waste loading of about 35%) with a PUREX-type waste composition (high Fe{sub 2}O{sub 3} composition), and to perform two pilot-scale runs on the large size platform equipped with a 650 mm diameter CCIM at the CEA Marcoule. The objectives of the demonstrations were 1) to show the feasibility of processing a representative SRS sludge surrogate using continuous slurry feeding, 2) to produce a glass that would meet the acceptance specifications with an increased waste loading when compared to what is presently achieved at the DWPF, and 3) achieve improved waste throughputs. This presentation describes the platform and the very encouraging results obtained from the demonstration performed at temperatures, specific throughputs and waste loadings that overcome current DWPF limits. Results from the initial exploratory run and second demonstration run include 1) production of a glass product that achieved the targeted glass composition that was more durable than the standard Environmental Assessment (EA) glass, 2) successful slurry feeding of the CCIM, and 3) promising waste

  14. Elecsys CEA, PSA and AFP. Clinical results of a multicentre evaluation.

    PubMed

    Uhl, W; Chan, D W; Jones, K; Kelley, C; Assmann, G; von Eckardstein, A; Sägers, A; Yvert, J P; Schneider, A M; Torralba, A; Fuentes-Arderiu, X; Gonzalez de la Presa, B; Vives, M; Greiling, H; Eberle, A; Niederau, C M; Cremer, P; Reiter, W; Vogeser, M; Neumeier, D; Luppa, P; Huber, U

    1998-01-01

    Three tumormarker assays, Elecsys CEA, PSA and AFP, have been evaluated in an international multicentre study to characterize their clinical performance and to verify the comparability with the corresponding tests of the Enzymun-Test product line and other methods. For each of the markers results were obtained from four laboratories. On the basis of 314 and 199 specimens respectively, (preliminary) reference ranges could be established for CEA and PSA. For the prostate marker, the age dependence of the antigen level could be clearly confirmed. Mean concentrations range between 0.51 ng/ml (< 40 years) and 3.57 ng/ml (> 70 years). Referring to CEA, 95th percentiles of 4.31 ng/ml and 2.69 ng/ml were elaborated for smokers and nonsmokers. In general, good to excellent correlations (r > 0.98) were found between the Elecsys and Enzymun-Tests. Regarding the systematic comparability of both systems, most of the slopes derived from the individual method comparison studies are within the +/- 10% range of the respective standardization results. The specific distribution pattern of the individual tumormarker values elaborated with sample material of known clinical background, reflects the well established categorization of different benign and malignant diseases according to their characteristic marker levels. Of utmost importance, however, is the excellent comparability of the Elecsys assays with the corresponding Enzymun-Tests and the FDA approved AIA 1200 tests from TOSOH in follow-up studies. Almost superimposable concentration curves guarantee that identical diagnostic information is derived from all three methods. Especially for PSA, a series of measurements on sera of prostatectomized patients proved the usability and clinical value of the test also for this particular indication. For either one of the Elecsys tests, the feasibility of using plasma as sample material was verified. PMID:9677672

  15. Development of recycled plastic composites for structural applications from CEA plastics

    NASA Astrophysics Data System (ADS)

    Bhalla, Agrim

    Plastic waste from consumer electronic appliances (CEAs) such as computer and printer parts including Polystyrene (PS), Acrylonitrile Butadiene Styrene (ABS), Polystyrene (PS) and PC/ABS were collected using handheld FTIR Spectrophotometer. The blends of these plastics with High Density Polyethylene (HDPE) are manufactured under special processing conditions in a single screw compounding injection molding machine. The blends are thermoplastics have high stiffness and strength, which may enhance the mechanical properties of HDPE like tensile modulus, ultimate tensile strength, tensile break and tensile yield. These composites have a potential to be used for the future application of recycled plastic lumber, thus replacing the traditional wood lumber.

  16. R and D Programs and Policy within the CEA-AREVA Joint Vitrification Lab (LCV) - 13592

    SciTech Connect

    Piroux, Jean Christophe; Paradis, Luc; Ladirat, Christian; Brueziere, Jerome; Chauvin, Eric

    2013-07-01

    Waste management is a key issue for the reprocessing industry; furthermore, vitrification is considered as the reference for nuclear waste management. In order to further improve and strengthen their historical cooperation in high temperature waste management, the CEA, R and D organization, and AREVA, Industrial Operator, decided, in September 2010, to create a Joint Vitrification Laboratory within the framework of a strategic partnership. The main objectives of the CEA-AREVA Joint Vitrification Laboratory (LCV) are (i) support AREVA's activities, notably in its La Hague plants and for new projects, (ii) strengthen the CEA's lead as a reference laboratory in the field of waste conditioning. The LCV is mandated to provide strong, innovative solutions through the performance of R and D on processes and materials for vitrification, fusion and incineration, for high, intermediate and low level waste. The activities carried out in the LCV include academic research on containment matrices (formulation, long-term behaviour), and the improvement of current technologies/development of new ones in lab-scale to full-scale pilot facilities, in non-radioactive and radioactive conditions, including modelling and experimental tools. This paper focuses on the programs and policy managed within the LCV, as well as the means employed by the CEA and AREVA to meet common short-,mid- and long-term challenges, from a scientific and industrial point of view. Among other things, we discuss the technical support provided for the La Hague vitrification facilities on hot melter and CCIM technologies, the start-up of new processes (decommissioning effluents, UMo FP) with CCIM, the preparation of future processes by means of an assessment of new technologies and containment matrices (improved glasses, ceramics, etc.), as well as incineration/vitrification for organic and metallic mixed waste or metallic fusion. The close relationship between the R and D teams and industrial operators enables

  17. Charting a course through the CEAs: diagnosis and management of medullary thyroid cancer.

    PubMed

    Rowe, Christopher W; Bendinelli, Cino; McGrath, Shaun

    2016-09-01

    Medullary thyroid cancer (MTC) is an uncommon thyroid cancer that requires a high index of suspicion to facilitate diagnosis of early-stage disease amenable to surgical cure. The challenges of diagnosis, as well as management in the setting of persistent disease, are explored in the context of a case presenting with the incidental finding of elevated carcinoembryonic antigen (CEA) and an (18) F-fluorodeoxyglucose positron emission tomography ((18) F-FDG-PET)-positive thyroid incidentaloma detected following treatment of colorectal cancer. Strategies to individualize prognosis, and emerging PET-based imaging modalities, particularly the potential role of (18) F-DOPA-PET in staging, are reviewed. PMID:27230389

  18. GREGOR telescope: start of commissioning

    NASA Astrophysics Data System (ADS)

    Volkmer, R.; von der Lühe, O.; Denker, C.; Solanki, S.; Balthasar, H.; Berkefeld, T.; Caligari, P.; Collados, M.; Halbgewachs, C.; Heidecke, F.; Hofmann, A.; Klvana, M.; Kneer, F.; Lagg, A.; Popow, E.; Schmidt, D.; Schmidt, W.; Sobotka, M.; Soltau, D.; Strassmeier, K.

    2010-07-01

    With the integration of a 1-meter Cesic primary mirror the GREGOR telescope pre-commissioning started. This is the first time, that the entire light path has seen sunlight. The pre-commissioning period includes testing of the main optics, adaptive optics, cooling system, and pointing system. This time was also used to install a near-infrared grating spectro-polarimeter and a 2D-spectropolarimeter for the visible range as first-light science instruments. As soon as the final 1.5 meter primary mirror is installed, commissioning will be completed, and an extended phase of science verification will follow. In the near future, GREGOR will be equipped with a multi-conjugate adaptive optics system that is presently under development at KIS.

  19. Commission 41: History of Astronomy

    NASA Astrophysics Data System (ADS)

    Gurshtein, Alexander A.; Nha, Il-Seong; Ruggles, Clive L. N.; DeVorkin, David H.; Dick, Wolfgang R.; Kochhar, Rajesh; Nakamura, Tsuko; Pigatto, Luisa; Stephenson, F. Richard; Warner, Brian

    2007-12-01

    On Tuesday 22 August 2006 approximately 40 people attended the Commission 41 History of Astronomy Business Meeting at the IAU XXVI General Assembly in Prague. Commission president Alex Gurshtein opened the meeting, welcoming the commission members and calling for a moment of silence for those members who passed away in the last triennium. David DeVorkin was appointed recording secretary for the meeting, with Steven Dick as the scruitineer of the ballot. A moment of silence was then observed in the memory of members departed over the last triennium, including: Jerzy Dobrzycki (Poland), Robert Duncan (Australia), Mohammad Edalati (Iran), Philip Morrison (USA), John Perdix (Australia), Neil Porter (Ireland), Gibson Reaves (USA), Brian Robinson (Australia), and Raymond E. White (USA).

  20. Division a Commission 8: Astrometry

    NASA Astrophysics Data System (ADS)

    Zacharias, Norbert; Brown, Anthony; Evans, Dafydd; Chen, Li; Gouda, Naoteru; Makarov, Valeri; Shulga, Aleksandr; Souchay, Jean; Teixeira, Rama; Unwin, Stephen

    2016-04-01

    Commission 8 has regularly published triennial reports in the past and the current OC therefore voted to adopt a traditional format also for this special Legacy issue of the IAU Transactions. The outgoing President is grateful for the support of many Commission members who contributed to this report. Our contribution consists of 3 parts: 1) this introduction, providing a general overview and highlights of recent research in astrometry, 2) a summary of the astrometry business & science meeting at the 2015 IAU General Assembly, and 3) the activity report of our Commisson covering the mid-2012 to mid-2015 period.

  1. Treatment of actinide exposures: a review of Ca-DTPA injections inside CEA-COGEMA plants.

    PubMed

    Grappin, Louise; Berard, Philippe; Menetrier, Florence; Carbone, Lise; Courtay, Catherine; Castagnet, Xavier; Le Goff, Jean-Pierre; Neron, Marie-Odile; Piechowski, Jean

    2007-01-01

    Calcium diethylenetriamine pentacetate (Ca-DTPA) has been used for medical treatment of plutonium and americium contaminations in the CEA and COGEMA plants from 1970 to 2003. This paper is a survey of the injections Ca-DTPA administered as a chelating molecule and it will be a part of the authorisation process for Ca-DTPA by intravenous administration. Out of 1158 injections administered to 469 persons, 548 events of possible or confirmed contamination were reported. These employees were followed by occupational physicians according to the current French regulations. These incidents took place at work, were most often minor, not requiring follow-up treatment. The authors present (1) a synthesis of the most recent findings. Due to its short biological half-time and its limited action in the blood, Ca-DTPA does not chelate with plutonium and americium as soon as these elements are deposited in the target organs. It justifies an early treatment, even in cases of suspected contamination followed by additional injections if necessary (2) data concerning these 1158 injections (route of contamination, dosage, adverse effects, etc.) The authors also investigated a study on the efficacy of the product on a group of persons having received five or more injections. These results were compared with the efficacy estimated theoretically. Dosages and therapeutic schemes were proposed based on these observations. This synthesis is the result of a collective work having mobilised the occupational medicine departments, the medical laboratories inside a working group CEA-COGEMA-SPRA. PMID:17940101

  2. High intensity ECR ion source (H+, D+, H-) developments at CEA/Saclay

    NASA Astrophysics Data System (ADS)

    Gobin, R.; Beauvais, P.-Y.; Bogard, D.; Charruau, G.; Delferrière, O.; Menezes, D. De; France, A.; Ferdinand, R.; Gauthier, Y.; Harrault, F.; Jannin, J.-L.; Lagniel, J.-M.; Leroy, P.-A.; Mattéi, P.; Sherman, J.; Sinanna, A.; Ausset, P.; Bousson, S.; Pottin, B.

    2002-02-01

    Source of light ions with high intensities The (SILHI) source has been producing proton beams since 1996. The first aim is to produce up to 100 mA cw beams at 95 keV for the injector of protons for high intensity demonstrator. This prototype is developed by a CEA/DSM-CNRS/IN2P3 collaboration for applications such as accelerator driven systems for nuclear waste transmutation, production of radioactive ion beams, or secondary particles. To measure installation reliability, continuous 5 day long runs have been performed. In October 1999, a 99.96% availability was achieved with a single short beam off and a 103 H uninterrupted beam. A new extraction system leads to lower beam losses and higher LEBT transparency. SILHI now produces a 95 keV-130 mA total beam with a proton fraction higher than 80%. Up to a 157 mA (247 mA/cm2) total cw beam has been extracted. The new EPICS control system, electromagnetic interference hardened devices and automatic control procedures now allow us to do longer runs. To analyze the reliability of these upgrades, a 4 week test was planned. In the framework of the International Fusion Material Irradiation Facility project CEA participation, 135 mA-95 kV deuteron pulsed beams were produced. Extraction simulations and recent SILHI results are also presented. In addition, a new test bench has been recently developed to analyze H- beam production.

  3. International Fusion Materials Irradiation Facility injector acceptance tests at CEA/Saclay: 140 mA/100 keV deuteron beam characterization.

    PubMed

    Gobin, R; Bogard, D; Cara, P; Chauvin, N; Chel, S; Delferrière, O; Harrault, F; Mattei, P; Mosnier, A; Senée, F; Shidara, H; Okumura, Y

    2014-02-01

    In the framework of the ITER broader approach, the International Fusion Materials Irradiation Facility (IFMIF) deuteron accelerator (2 × 125 mA at 40 MeV) is an irradiation tool dedicated to high neutron flux production for future nuclear plant material studies. During the validation phase, the Linear IFMIF Prototype Accelerator (LIPAc) machine will be tested on the Rokkasho site in Japan. This demonstrator aims to produce 125 mA/9 MeV deuteron beam. Involved in the LIPAc project for several years, specialists from CEA/Saclay designed the injector based on a SILHI type ECR source operating at 2.45 GHz and a 2 solenoid low energy beam line to produce such high intensity beam. The whole injector, equipped with its dedicated diagnostics, has been then installed and tested on the Saclay site. Before shipment from Europe to Japan, acceptance tests have been performed in November 2012 with 100 keV deuteron beam and intensity as high as 140 mA in continuous and pulsed mode. In this paper, the emittance measurements done for different duty cycles and different beam intensities will be presented as well as beam species fraction analysis. Then the reinstallation in Japan and commissioning plan on site will be reported. PMID:24593497

  4. Radioimmunoimaging of metastatic medullary carcinoma of the thyroid gland using an indium-111-labeled monoclonal antibody to CEA

    SciTech Connect

    Edington, H.D.; Watson, C.G.; Levine, G.; Tauxe, W.N.; Yousem, S.A.; Unger, M.; Kowal, C.D.

    1988-12-01

    Elevated levels of carcinoembryonic antigen (CEA) or calcitonin after surgical therapy for medullary carcinoma of the thyroid gland (MCT) indicate the presence of residual or metastatic disease. CEA elevations appear to be prognostically more reliable in patients with metastatic disease and suggest a more virulent tumor. Attempts to stage the disease with use of conventional imaging techniques are usually inadequate, as is the therapy for disseminated or recurrent MCT. An indium-111-labeled anti-CEA monoclonal antibody (ZCE-025) was used to image metastases in a patient with MCT. Potential applications of monoclonal antibody technology in the management of MCT would include (1) preoperative differentiation of unicentric from multicentric thyroid gland involvement, (2) detection of regional or distant metastases or both, (3) measurement of response to systemic therapy, and (4) the facilitation of radionuclide immunoconjugate therapy.

  5. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 16 Commercial Practices 1 2012-01-01 2012-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in...

  6. 10 CFR 110.91 - Commission consultations.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Commission consultations. 110.91 Section 110.91 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Public Participation Procedures Concerning License Applications § 110.91 Commission consultations. The Commission...

  7. Securities and Exchange Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-12-20

    ... [The Regulatory Plan and Unified Agenda of Federal Regulatory and Deregulatory Actions] Part XXIV Securities and Exchange Commission Semiannual Regulatory Agenda ] SECURITIES AND EXCHANGE COMMISSION (SEC) SECURITIES AND EXCHANGE COMMISSION 17 CFR Ch. II Regulatory Flexibility Agenda AGENCY: Securities and Exchange Commission. ACTION:...

  8. 47 CFR 1.1528 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false Commission review. 1.1528 Section 1.1528... Applications § 1.1528 Commission review. Either the applicant or Bureau counsel may seek Commission review of the initial decision on the application, or the Commission may decide to review the decision on...

  9. 47 CFR 1.5004 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Commission action. 1.5004 Section 1.5004 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL PRACTICE AND PROCEDURE Exempt Telecommunications Companies § 1.5004 Commission action. If the Commission has not issued an order granting or denying...

  10. 10 CFR 2.806 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Commission action. 2.806 Section 2.806 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Rulemaking § 2.806 Commission action. The Commission will incorporate in the notice of adoption of a regulation...

  11. 76 FR 63325 - National Indian Gaming Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-12

    ... Register on November 18, 2010. 75 FR 70680. The Commission's regulatory review process established a tribal... National Indian Gaming Commission AGENCY: National Indian Gaming Commission. ACTION: Notice of no action. SUMMARY: On November 18, 2010, the National Indian Gaming Commission (NIGC) issued a Notice of Inquiry...

  12. 16 CFR 4.15 - Commission meetings.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false Commission meetings. 4.15 Section 4.15... RULES § 4.15 Commission meetings. (a) In general. (1) Meetings of the Commission, as defined in 5 U.S.C... announcements of meetings. For each meeting, the Commission shall announce: (i) The time, place and...

  13. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 1 2011-01-01 2011-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in...

  14. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 1 2011-04-01 2011-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same...

  15. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 1 2012-04-01 2012-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same...

  16. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 1 2013-04-01 2013-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same...

  17. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 2 2014-04-01 2014-04-01 false The Commission. 140.10 Section...) ORGANIZATION, FUNCTIONS, AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the...

  18. 17 CFR 140.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 1 2010-04-01 2010-04-01 false The Commission. 140.10 Section..., AND PROCEDURES OF THE COMMISSION Functions § 140.10 The Commission. The Commission is composed of a Chairman and four other Commissioners, not more than three of whom may be members of the same...

  19. 16 CFR 0.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 1 2010-01-01 2010-01-01 false The Commission. 0.1 Section 0.1 Commercial Practices FEDERAL TRADE COMMISSION ORGANIZATION, PROCEDURES AND RULES OF PRACTICE ORGANIZATION § 0.1 The Commission. The Federal Trade Commission is an independent administrative agency which was organized in...

  20. 47 CFR 1.1528 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 47 Telecommunication 1 2014-10-01 2014-10-01 false Commission review. 1.1528 Section 1.1528... Applications § 1.1528 Commission review. Either the applicant or Bureau counsel may seek Commission review of the initial decision on the application, or the Commission may decide to review the decision on...

  1. 47 CFR 1.1528 - Commission review.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 47 Telecommunication 1 2013-10-01 2013-10-01 false Commission review. 1.1528 Section 1.1528... Applications § 1.1528 Commission review. Either the applicant or Bureau counsel may seek Commission review of the initial decision on the application, or the Commission may decide to review the decision on...

  2. HIQA's CEA of Breast Screening: Pragmatic Policy Recommendations are Welcome, but ACERs Reported as ICERs are Not.

    PubMed

    O'Mahony, James F; Normand, Charles

    2015-12-01

    The Health Information and Quality Authority (HIQA) is Ireland's statutory cost-effectiveness analysis (CEA) agency. It recently published a CEA of screening strategies for women at elevated risk of breast cancer. Although the strategies recommended by HIQA exceed Ireland's cost-effectiveness threshold, they can reasonably be welcomed as a pragmatic response to constraints on disinvestment and are expected to improve screening cost-effectiveness. What is not welcome, however, is HIQA's reporting of average cost-effectiveness ratios (ACERs) as incremental cost-effectiveness ratios (ICERs). The distinction between ACERs and ICERs is well understood in CEA, as is the fact that ICERs not ACERs are the appropriate metric to determine cost-effectiveness. This article critiques HIQA's reporting, considering the implications for the particular case of breast cancer screening and the broader context of consistency of and confidence in CEA as a guide to resource allocation in Ireland. The reporting of ACERs as ICERs is unlikely to be of any great significance in the particular case of screening women at elevated risk of breast cancer, given likely constraints on disinvestment. Despite this, ICERs still need to be reported correctly. If thresholds are exceeded in certain cases, then it is important that decision makers appreciate by how much. More generally, using ACERs in some cases and ICERs in others raises concerns that methods are being applied inconsistently, which risks compromising confidence in CEA in Ireland. As Ireland's statutory CEA authority, HIQA has a special onus of responsibility to ensure established methods are applied correctly. PMID:26686777

  3. Comparison of Serum CA72-4 and CEA Levels in Patient with Endoscopically Suspected Gastric Carcinoma.

    PubMed

    Rehena, Z; Ghosh, C K; Afroz, F; Alam, M B; Ferdousi, S; Mahmuduzzaman, M; Sultana, T; Ahmed, A N

    2015-07-01

    Several serum tumour markers have been described for gastric cancer. Preoperative level of tumor marker helps to predict the diagnosis of gastric carcinoma. CA72-4 as a serum tumour marker for gastric cancer is evaluated, and compared its utility in this regard with that of carcinoembryonic antigen (CEA). Analysis of gastric carcinoma by serum levels of CEA and CA72-4 and their correlation with histopathology help the clinician to develop his management strategies for gastric carcinoma. A prospective observational study was carried out in the Department of Clinical Pathology, Bangabandhu Sheikh Mujib Medical University (BSMMU) in collaboration with Department of Surgery BSMMU, DMCH, Delta Hospital Limited, Dhaka, during the period of October 2010 to September 2011. Serum CA72-4 and CEA were analyzed in 71 endoscopically suspected patients for gastric carcinoma. Among them 58 cases were diagnosed as malignant gastric disease and 13 cases were nonmalignant gastric disease. Sensitivity of CA 72-4 and CEA were 48.3% and 31% respectively and specificity were 92.3% and 76.9% respectively. In poorly differentiated carcinoma, positivity for CA72-4 and CEA were 55.6% and 36.1% respectively. Because of the high positivity of CA72-4 in poorly differentiated carcinoma, CA72-4 is reliable tumour marker in advanced cases. As the sensitivity of CA72-4 was more than that of CEA in diagnosis of gastric cancer, CA72-4 can be used in conjunction with other diagnostic tests like endoscopy that would be more helpful for the patients. PMID:26329953

  4. Different Levels of CEA, CA153 and CA125 in Milk and Benign and Malignant Nipple Discharge

    PubMed Central

    Zhao, Song; Mei, Yu; Wang, Jianli; Zhang, Kai; Ma, Rong

    2016-01-01

    Background The aim of this study was to assess the diagnostic values of three breast tumor markers (i.e., CEA, CA153 and CA125) in milk and nipple discharge in the prediction of different breast diseases diagnoses. Methods Three hundred thirty-six patients (96 breast cancer and 240 benign disease patients) with nipple discharge and a control group of 56 healthy parturient participants were enrolled in the present study. Nipple discharge samples were preoperatively collected from the patients, and milk was collected from the colostrum of the parturient participants. The samples were assayed for the CEA, CA153 and CA125 levels. Cutoff values were determined for the detection of breast diseases using ROC curves. Results The levels of CEA, CA153 and CA125 were significantly different between the nipple discharge and the milk (all ps < 0.001). In the nipple discharge, the CEA and CA153 levels in the breast cancer group were significantly greater than those in the benign group (all ps < 0.001), and cutoff values of 263.3 ng/mL and 1235.3 U/mL, respectively, were established. However, the expression of CA125 did not differ significantly between the breast cancer and benign groups. Conclusion Differences in the apparent expression levels of CEA, CA153 and CA125 in patients with nipple discharge and healthy persons were validated. The present data suggest that CEA and CA153 might potentially be useful in the differential diagnoses of benign tumors and breast cancer. CA125 did not seem to be useful for breast cancer detection. PMID:27327081

  5. Clinical significance of joint detection of serum CEA, SCCA, and bFGF in the diagnosis of lung cancer

    PubMed Central

    Zhao, Wei; Yu, Haixiang; Han, Zhifeng; Gao, Nan; Xue, Jinru; Wang, Yan

    2015-01-01

    Lung cancer is a type of malignant tumor with highest morbidity and mortality. This study tested three tumor marker levels including CEA, SCCA, and bFGF to explore their value in lung cancer diagnosis and pathological type judgment. Venous blood was extracted from lung cancer patients, lung benign lesion patients and healthy control. Electrochemiluminescence immunoassay was applied to detect serum CEA and SCCA content. ELISA was used to test serum bFGF level. Serum CEA, SCCA, and bFGF levels and positive rates were significantly higher in lung cancer group than that of lung benign disease group and health control (P < 0.05). bFGF showed higher detection sensitivity than CEA in lung cancer (P < 0.05). Three joint detection sensitivity was higher than single test (P < 0.05), while its specificity was lower (P < 0.05), and the accuracy presented no significant difference. Serum CEA and SCCA levels and positive rates were obviously higher in non-small cell lung cancer patients when compared with small cell lung cancer patients (P < 0.05), while bFGF level was similar between small cell lung cancer and non-small cell lung cancer. bFGF showed higher detection rate than SCCA in small cell lung cancer (P < 0.05). Three joint detection exhibited higher positive rate in small cell lung cancer and non-small lung cancer than single test. Serum CEA, SCCA and bFGF joint detection improved detection sensitivity in lung cancer and had important reference value for pathological type deduction. PMID:26464712

  6. 75 FR 11166 - Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-03-10

    ... From the Federal Register Online via the Government Publishing Office ] DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission; Notice of Joint Meeting of the Nuclear Regulatory Commission and the Federal Energy Regulatory Commission March 2,...

  7. Surrogacy commissioning fathers and HIV.

    PubMed

    Jordaan, Donrich W

    2014-01-01

    Surrogacy is not regulated by a single legal instrument only, nor is confirmation of a surrogacy agreement by the High Court an unqualified green light for the surrogacy process to proceed. In the context of the HIV status of the commissioning father, whose gametes are to be used for the conception of the child in pursuance of a surrogacy agreement, the intended in vitro fertilisation of the surrogate mother may only take place on condition that the commissioning father, and his semen, have been tested for HIV; that he has consented to his HIV status being made available to the surrogate mother, and if he is HIV-positive, that sperm washing will be used to minimise the risk of infection and that the surrogate mother has been informed of his HIV status, and given her informed consent.  PMID:24388075

  8. Commissioning: perspectives from the ground.

    PubMed

    Dawda, Paresh; True, Angelene; Wells, Leanne

    2016-01-01

    Primary Health Networks (PHNs) have been tasked with two key objectives to be achieved through commissioning. Public value aims can be achieved by developing operational capability in the context of an authorising environment. Public value will need to focus on system level outcomes from multiple perspectives, including a consumer perspective. The authorising environment will require policymakers to allow time for PHNs to mature into their role. It will require an environment of effective collaboration amongst multiple stakeholders including consumers. The operational capability will need to ensure highly competent managers and clinical leadership working in a symbiotic relationship. Although some Medicare Locals demonstrated commissioning capacity and capability, this will need to be scaled up at-pace in the new healthcare landscape in order for PHNs to optimally fulfil their roles. PMID:27469048

  9. Commissioning of the LCLS LINAC

    SciTech Connect

    Loos, H.; Akre, R.; Brachmann, A.; Decker, F.-J.; Ding, Y.; Dowell, D.; Emma, P.; Frisch, J.; Gilevich, S.; Hays, G.; Hering, Ph.; Huang, Z.; Iverson, R.; Limborg-Deprey, C.; Miahnahri, A.; Molloy, S.; Nuhn, H.-D.; Turner, J.; Welch, J.; White, W.; Wu, J.; /SLAC /Stanford U., Appl. Phys. Dept.

    2010-06-11

    The Linac Coherent Light Source (LCLS) X-ray free electron laser project is currently under construction at the Stanford Linear Accelerator Center (SLAC). A new injector and upgrades to the existing accelerator were installed in two phases in 2006 and 2007. We report on the commissioning of the injector, the two new bunch compressors at 250MeV and 4.3 GeV, and transverse and longitudinal beam diagnostics up to the end of the existing linac at 13.6 GeV. The commissioning of the new transfer line from the end of the linac to the undulator is scheduled to start in November 2008 and for the undulator in March 2009 with first light to be expected in July 2009.

  10. Population commission discusses international migration.

    PubMed

    1997-01-01

    At the 30th session of the Commission on Population and Development during February 24-28, 1997, international migration was the main topic, with special linkages between migration and development and on gender issues and the family. New and emerging issues were also considered. Members stressed the need for more reliable data on migration, the direction of migrants flows, and the characteristics of migrants. The Commission requested a task force on basic social services to hold a technical symposium of experts on international migration in 1998. Its chair, Dr. Nafis Sadik, said that migration issues should based on the reality of choice not on coercive measures or quotas. Almost half of the migrants globally are women. The Commission was given a new impetus by the International Conference on Population and Development held at Cairo in 1994. Migration pressures intensified in the second half of the 1980s and in the early 1990s, creating areas of concern: the negative impact of short-term migration on working conditions in host countries; migration pressures emanating from climatic change; the protection of migrant women and their children; the right of receiving countries to regulate access to their territory; the adverse consequences of forced migration; the situation of persons whose asylum claims have been rejected; the trafficking in women and children, prostitution and coercive adoption; and the sudden and massive arrival of refugees in need of international protection. The 1998 session of the Commission will feature the theme of health and mortality, with special emphasis on the linkages between health and development and on gender and age. PMID:12292475

  11. Operation and commissioning of IFMIF (International Fusion Materials Irradiation Facility) LIPAc injector.

    PubMed

    Okumura, Y; Gobin, R; Knaster, J; Heidinger, R; Ayala, J-M; Bolzon, B; Cara, P; Chauvin, N; Chel, S; Gex, D; Harrault, F; Ichimiya, R; Ihara, A; Ikeda, Y; Kasugai, A; Kikuchi, T; Kitano, T; Komata, M; Kondo, K; Maebara, S; Marqueta, A; O'Hira, S; Perez, M; Phillips, G; Pruneri, G; Sakamoto, K; Scantamburlo, F; Senée, F; Shinto, K; Sugimoto, M; Takahashi, H; Usami, H; Valette, M

    2016-02-01

    The objective of linear IFMIF prototype accelerator is to demonstrate 125 mA/CW deuterium ion beam acceleration up to 9 MeV. The injector has been developed in CEA Saclay and already demonstrated 140 mA/100 keV deuterium beam [R. Gobin et al., Rev. Sci. Instrum. 85, 02A918 (2014)]. The injector was disassembled and delivered to the International Fusion Energy Research Center in Rokkasho, Japan. After reassembling the injector, commissioning has started in 2014. Up to now, 100 keV/120 mA/CW hydrogen and 100 keV/90 mA/CW deuterium ion beams have been produced stably from a 10 mm diameter extraction aperture with a low beam emittance of 0.21 π mm mrad (rms, normalized). Neutron production by D-D reaction up to 2.4 × 10(9) n/s has been observed in the deuterium operation. PMID:26931957

  12. CEAS/AIAA/ICASE/NASA Langley International Forum on Aeroelasticity and Structural Dynamics 1999. Pt. 2

    NASA Technical Reports Server (NTRS)

    Whitlow, Jr., Woodrow (Editor); Todd, Emily N. (Editor)

    1999-01-01

    The proceedings of a workshop sponsored by the Confederation of European Aerospace Societies (CEAS), the American Institute of Aeronautics and Astronautics (AIAA), the National Aeronautics and Space Administration (NASA), Washington, D.C., and the Institute for Computer Applications in Science and Engineering (ICASE), Hampton, Virginia, and held in Williamsburg, Virginia June 22-25, 1999 represent a collection of the latest advances in aeroelasticity and structural dynamics from the world community. Research in the areas of unsteady aerodynamics and aeroelasticity, structural modeling and optimization, active control and adaptive structures, landing dynamics, certification and qualification, and validation testing are highlighted in the collection of papers. The wide range of results will lead to advances in the prediction and control of the structural response of aircraft and spacecraft.

  13. Science and Technology Research and Development in Support to ITER and the Broader Approach at CEA

    SciTech Connect

    Becoulet, A.; Hoang, G T; Abiteboul, J.; Achard, J.; Alarcon, T.; Klepper, C Christopher

    2013-01-01

    In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented.

  14. Recent progress on minor-actinide-bearing oxide fuel fabrication at CEA Marcoule

    NASA Astrophysics Data System (ADS)

    Lebreton, Florent; Prieur, Damien; Horlait, Denis; Delahaye, Thibaud; Jankowiak, Aurélien; Léorier, Caroline; Jorion, Frédéric; Gavilan, Elisabeth; Desmoulière, François

    2013-07-01

    Partitioning and transmutation (P&T) of minor actinides (MA: americium, neptunium and curium) in fast neutron reactors or accelerator-driven systems is a route envisaged to reduce nuclear waste inventory. Over the years, several modes of P&T were proposed, each being based on the use of dedicated fuels such as inert-matrix fuels, MA-bearing MOX or MA-bearing blankets. In this context, progress on the manufacturing of such fuels is a key-challenge in order to render P&T viable at the industrial scale. Here, MA-bearing oxide fuel fabrication and characterization conducted in the CEA Marcoule Atalante facility is reviewed. A particular attention is also given to the research conducted on uranium-americium mixed-oxides fuels, which are now considered the reference fuels for MA transmutation in France.

  15. GEDEON: A joint venture between research (CEA and CNRS) and industry (EDF and FRAMATOME)

    NASA Astrophysics Data System (ADS)

    Schapira, J. P.

    1999-07-01

    Nuclear waste partitionning and transmutation (P & T) are considered in France as an official line of research, in accordance with the Law of December 30, 1991 concerning research in the field of long lived and highly active nuclear waste. A research group called GEDEON ( GEstion des DEchets par des Options Nouvelles) has been set up between CEA, CNRS, EDF and FRAMATOME with the aim to carry out basic research related to the use of accelerator driven subcritical systems (ADS) and of thorium as an option to reduce the waste long term impacts. In the partners agreement of GEDEON, the following subjects have been identified: spallation physics, nuclear data, subcritical neutronic studies, materials, thorium, system and scenario studies. The organization as well as the scientific program and activities of GEDEON are presented.

  16. Evaluation of the CEAS model for barley yields in North Dakota and Minnesota

    NASA Technical Reports Server (NTRS)

    Barnett, T. L. (Principal Investigator)

    1981-01-01

    The CEAS yield model is based upon multiple regression analysis at the CRD and state levels. For the historical time series, yield is regressed on a set of variables derived from monthly mean temperature and monthly precipitation. Technological trend is represented by piecewise linear and/or quadriatic functions of year. Indicators of yield reliability obtained from a ten-year bootstrap test (1970-79) demonstrated that biases are small and performance as indicated by the root mean square errors are acceptable for intended application, however, model response for individual years particularly unusual years, is not very reliable and shows some large errors. The model is objective, adequate, timely, simple and not costly. It considers scientific knowledge on a broad scale but not in detail, and does not provide a good current measure of modeled yield reliability.

  17. Validation of the 4C code against data from the HELIOS loop at CEA Grenoble

    NASA Astrophysics Data System (ADS)

    Zanino, R.; Bonifetto, R.; Casella, F.; Savoldi Richard, L.

    2013-01-01

    We complete the first validation campaign of the Cryogenic Circuit Conductor and Coil (4C) code, focusing on the cryogenic circuit module of 4C, which is based on the component models from the recently developed "Cryogenics" Modelica library. Measured data from the HELIOS facility (HElium Loop for hIgh LOads Smoothing) at CEA Grenoble, France, are used as reference. HELIOS includes a supercritical He loop (cold circulator, pipes equipped with resistive heaters, control and bypass valves, heat exchangers) and a saturated He bath. A repetitive heat pulse test is simulated with 4C. The computed evolution of temperature, pressure and mass flow rate at different circuit locations, both in the loop and in the bath, shows a very good agreement with the measurements.

  18. TRIPOLI-4®, CEA, EDF and AREVA Reference Monte Carlo Code

    NASA Astrophysics Data System (ADS)

    2014-06-01

    This paper presents an overview of TRIPOLI-4®, the fourth generation of the 3D continuous-energy Monte Carlo code developed by the Service d'Etudes des Réacteurs et de Mathématiques Appliquées (SERMA) at CEA Saclay. The paper surveys the generic features: programming language, parallel operation, tracked particles, nuclear data, geometry, simulation modes, standard variance reduction techniques, sources, tracking and collision algorithms, tallies, sensitivity studies. Moreover, specific and recent features are also detailed: Doppler broadening of the elastic scattering kernel, neutron and photon material irradiation, advanced variance reduction techniques, Green's functions, cycle correlation correction, nuclear data management and depletion capabilities. The productivity tools (T4G, SALOME TRIPOLI, T4RootTools), the Verification & Validation process and the distribution and licensing policy are finally presented.

  19. Science and technology research and development in support to ITER and the Broader Approach at CEA

    NASA Astrophysics Data System (ADS)

    Bécoulet, A.; Hoang, G. T.; Abiteboul, J.; Achard, J.; Alarcon, T.; Alba-Duran, J.; Allegretti, L.; Allfrey, S.; Amiel, S.; Ané, J. M.; Aniel, T.; Antar, G.; Argouarch, A.; Armitano, A.; Arnaud, J.; Arranger, D.; Artaud, J. F.; Audisio, D.; Aumeunier, M.; Autissier, E.; Azcona, L.; Back, A.; Bahat, A.; Bai, X.; Baiocchi, B.; Balaguer, D.; Balme, S.; Balorin, C.; Barana, O.; Barbier, D.; Barbuti, A.; Basiuk, V.; Baulaigue, O.; Bayetti, P.; Baylard, C.; Beaufils, S.; Beaute, A.; Bécoulet, M.; Bej, Z.; Benkadda, S.; Benoit, F.; Berger-By, G.; Bernard, J. M.; Berne, A.; Bertrand, B.; Bertrand, E.; Beyer, P.; Bigand, A.; Bonhomme, G.; Borel, G.; Boron, A.; Bottereau, C.; Bottollier-Curtet, H.; Bouchand, C.; Bouquey, F.; Bourdelle, C.; Bourg, J.; Bourmaud, S.; Brémond, S.; Bribiesca Argomedo, F.; Brieu, M.; Brun, C.; Bruno, V.; Bucalossi, J.; Bufferand, H.; Buravand, Y.; Cai, L.; Cantone, V.; Cantone, B.; Caprin, E.; Cartier-Michaud, T.; Castagliolo, A.; Belo, J.; Catherine-Dumont, V.; Caulier, G.; Chaix, J.; Chantant, M.; Chatelier, M.; Chauvin, D.; Chenevois, J.; Chouli, B.; Christin, L.; Ciazynski, D.; Ciraolo, G.; Clairet, F.; Clapier, R.; Cloez, H.; Coatanea-Gouachet, M.; Colas, L.; Colledani, G.; Commin, L.; Coquillat, P.; Corbel, E.; Corre, Y.; Cottet, J.; Cottier, P.; Courtois, X.; Crest, I.; Dachicourt, R.; Dapena Febrer, M.; Daumas, C.; de Esch, H. P. L.; De Gentile, B.; Dechelle, C.; Decker, J.; Decool, P.; Deghaye, V.; Delaplanche, J.; Delchambre-Demoncheaux, E.; Delpech, L.; Desgranges, C.; Devynck, P.; Dias Pereira Bernardo, J.; Dif-Pradalier, G.; Doceul, L.; Dong, Y.; Douai, D.; Dougnac, H.; Dubuit, N.; Duchateau, J.-L.; Ducobu, L.; Dugue, B.; Dumas, N.; Dumont, R.; Durocher, A.; Durocher, A.; Duthoit, F.; Ekedahl, A.; Elbeze, D.; Escarguel, A.; Escop, J.; Faïsse, F.; Falchetto, G.; Farjon, J.; Faury, M.; Fedorzack, N.; Féjoz, P.; Fenzi, C.; Ferlay, F.; Fiet, P.; Firdaouss, M.; Francisquez, M.; Franel, B.; Frauche, J.; Frauel, Y.; Futtersack, R.; Garbet, X.; Garcia, J.; Gardarein, J.; Gargiulo, L.; Garibaldi, P.; Garin, P.; Garnier, D.; Gauthier, E.; Gaye, O.; Geraud, A.; Gerome, M.; Gervaise, V.; Geynet, M.; Ghendrih, P.; Giacalone, I.; Gibert, S.; Gil, C.; Ginoux, S.; Giovannangelo, L.; Girard, S.; Giruzzi, G.; Goletto, C.; Goncalves, R.; Gonde, R.; Goniche, M.; Goswami, R.; Grand, C.; Grandgirard, V.; Gravil, B.; Grisolia, C.; Gros, G.; Grosman, A.; Guigue, J.; Guilhem, D.; Guillemaut, C.; Guillerminet, B.; Guimaraes Filho, Z.; Guirlet, R.; Gunn, J. P.; Gurcan, O.; Guzman, F.; Hacquin, S.; Hariri, F.; Hasenbeck, F.; Hatchressian, J. C.; Hennequin, P.; Hernandez, C.; Hertout, P.; Heuraux, S.; Hillairet, J.; Honore, C.; Hornung, G.; Houry, M.; Hunstad, I.; Hutter, T.; Huynh, P.; Icard, V.; Imbeaux, F.; Irishkin, M.; Isoardi, L.; Jacquinot, J.; Jacquot, J.; Jiolat, G.; Joanny, M.; Joffrin, E.; Johner, J.; Joubert, P.; Jourd'Heuil, L.; Jouve, M.; Junique, C.; Keller, D.; Klepper, C.; Kogut, D.; Kubič, M.; Labassé, F.; Lacroix, B.; Lallier, Y.; Lamaison, V.; Lambert, R.; Larroque, S.; Latu, G.; Lausenaz, Y.; Laviron, C.; Le, R.; Le Luyer, A.; Le Niliot, C.; Le Tonqueze, Y.; Lebourg, P.; Lefevre, T.; Leroux, F.; Letellier, L.; Li, Y.; Lipa, M.; Lister, J.; Litaudon, X.; Liu, F.; Loarer, T.; Lombard, G.; Lotte, P.; Lozano, M.; Lucas, J.; Lütjens, H.; Magaud, P.; Maget, P.; Magne, R.; Mahieu, J.-F.; Maini, P.; Malard, P.; Manenc, L.; Marandet, Y.; Marbach, G.; Marechal, J.-L.; Marfisi, L.; Marle, M.; Martin, C.; Martin, V.; Martin, G.; Martinez, A.; Martino, P.; Masset, R.; Mazon, D.; Mellet, N.; Mercadier, L.; Merle, A.; Meshcheriakov, D.; Messina, P.; Meyer, O.; Millon, L.; Missirlian, M.; Moerel, J.; Molina, D.; Mollard, P.; Moncada, V.; Monier-Garbet, P.; Moreau, D.; Moreau, M.; Moreau, P.; Morel, P.; Moriyama, T.; Motassim, Y.; Mougeolle, G.; Moulton, D.; Moureau, G.; Mouyon, D.; Naim Habib, M.; Nardon, E.; Négrier, V.; Nemeth, J.; Nguyen, C.; Nguyen, M.; Nicolas, L.; Nicolas, T.; Nicollet, S.; Nilsson, E.; N'Konga, B.; Noel, F.; Nooman, A.; Norscini, C.; Nouailletas, R.; Oddon, P.; Ohsako, T.; Orain, F.; Ottaviani, M.; Pagano, M.; Palermo, F.; Panayotis, S.; Parrat, H.; Pascal, J.-Y.; Passeron, C.; Pastor, P.; Patterlini, J.; Pavy, K.; Pecquet, A.-L.; Pégourié, B.; Peinturier, C.; Pelletier, T.; Peluso, B.; Petrzilka, V.; Peysson, Y.; Pignoly, E.; Pirola, R.; Pocheau, C.; Poitevin, E.; Poli, V.; Poli, S.; Pompon, F.; Porchy, I.; Portafaix, C.; Preynas, M.; Prochet, P.; Prou, M.; Ratnani, A.; Raulin, D.; Ravenel, N.; Renard, S.; Ricaud, B.; Richou, M.; Ritz, G.; Roche, H.; Roubin, P.; Roux, C.; Ruiz, K.; Sabathier, F.; Sabot, R.; Saille, A.; Saint-Laurent, F.; Sakamoto, R.; Salasca, S.; Salmon, T.; Salmon, T.; Samaille, F.; Sanchez, S.; Santagiustina, A.; Saoutic, B.; Sarazin, Y.; Sardain, P.; Schlosser, J.; Schneider, M.; Schwob, J.; Segui, J.; Seguin, N.; Selig, G.; Serret, D.; Signoret, J.; Signoret, J.; Simonin, A.; Soldaini, M.; Soler, B.; Soltane, C.; Song, S.; Sourbier, F.; Sparagna, J.; Spitz, P.; Spuig, P.; Storelli, A.; Strugarek, A.; Tamain, P.; Tena, M.; Theis, J.; Thomine, O.; Thouvenin, D.; Torre, A.; Toulouse, L.; Travère, J.; Tsitrone, E.; Turck, B.; Urban, J.; Vallet, J.-C.; Vallory, J.; Valognes, A.; Van Helvoirt, J.; Vartanian, S.; Verger, J.-M.; Vermare, L.; Vermare, C.; Vezinet, D.; Vicente, K.; Vidal, J.; Vignal, N.; Vigne, T.; Villecroze, F.; Villedieu, E.; Vincent, B.; Volpe, B.; Volpe, D.; Volpe, R.; Wagrez, J.; Wang, H.; Wauters, T.; Wintersdorff, O.; Wittebol, E.; Zago, B.; Zani, L.; Zarzoso, D.; Zhang, Y.; Zhong, W.; Zou, X. L.

    2013-10-01

    In parallel to the direct contribution to the procurement phase of ITER and Broader Approach, CEA has initiated research & development programmes, accompanied by experiments together with a significant modelling effort, aimed at ensuring robust operation, plasma performance, as well as mitigating the risks of the procurement phase. This overview reports the latest progress in both fusion science and technology including many areas, namely the mitigation of superconducting magnet quenches, disruption-generated runaway electrons, edge-localized modes (ELMs), the development of imaging surveillance, and heating and current drive systems for steady-state operation. The WEST (W Environment for Steady-state Tokamaks) project, turning Tore Supra into an actively cooled W-divertor platform open to the ITER partners and industries, is presented. Commissariat à l'Energie Atomique et aux énergies alternatives.

  20. Levels of CEA, CA153, CA199, CA724 and AFP in nipple discharge of breast cancer patients

    PubMed Central

    Zhao, Song; Mei, Yu; Wang, Yongmei; Zhu, Jiang; Zheng, Guixi; Ma, Rong

    2015-01-01

    The distinction between breast cancer and benign breast diseases with nipple discharge remains an important diagnostic challenge. The purpose of this study was to predict the potential usefulness of tumor markers in nipple discharge and to investigate the relationship of tumor markers and clinical characteristics with breast cancer.One hundred and eleven patients with nipple discharge received breast surgery from November 2013 to December 2014 were included in the study. We evaluated levels of five tumor markers (CEA, CA153, CA199, CA724 and AFP) prior to treatment. Patients were divided into two groups according to postoperative pathological results: 30 cases in breast cancer group and 81 cases in benign group. The relationships of clinical characteristics with breast cancer were investigated by multivariate analysis with a logistic regression model.It showed significant differences in levels of nipple discharge CEA (P < 0.001) and CA153 (P = 0.014), but not CA199 (P = 0.856), CA724 (P = 0.171), AFP (P = 0.834) among two groups. Logistic regression analysis demonstrated complaint, age, menopause, abnormal palpable mass, CEA and CA153 were associated with breast cancer. In summary, measurements of CA199, CA724 and AFP in nipple discharge are not of great clinical value. Detecting CEA and CA153 in nipple dischargecould potentially be used for the early detection of breast cancer with in high-risk populations. PMID:26885008

  1. "C.-E.A. Winslow and the early years of public health at Yale, 1915-1925".

    PubMed Central

    Viseltear, A. J.

    1982-01-01

    C.-E.A. Winslow was the first chairman of the Department of Public Health at the Yale University School of Medicine. This paper considers the development and changing agenda of his department, the structure of Yale University, and the maturation of public health as a discipline. Winslow's successes and failures are discussed as they relate to Yale and external societal influences. PMID:6753362

  2. P21 and CEA expression and AgNOR counts in dimethylhydrazine-induced colon carcinoma in rats

    PubMed Central

    Zhang, Zhi-Gang; Wu, Jing-Ying; Fu, Xiang-Dong; Gu, Da-Kun; Fang, Fang

    1997-01-01

    AIM: To study P21 and carcinoembryonic antigen (CEA) expression and to measure argyrophilic nucleolar organizer region (AgNOR) counts in various lesions of colonic mucosa and the mechanism of carcinogenesis. METHODS: Thirty-eight male Wistar rats were injected with dimethylhydrazine (DMH) once a week for 25 wk. P21 and CEA expression was detected by immunohistochemical methods, and AgNOR was counted by silver staining paraffin sections from various colonic lesions. RESULTS: The incidence of colonic carcinoma in DMH-treated rats was 71.05% (27/38), and lymph node metastasis occurred in six rats. Immunohistochemical studies showed that P21 was primarily expressed in dysplasia and carcinomas, while CEA was expressed in carcinomas and metastatic tumors. AgNOR counts were higher in dysplasia and carcinomas. There were significant differences in P21 and CEA expression between benign and malignant lesions (P < 0.05). The difference in AgNOR counts was also significant between normal and dysplastic tissues, and between dysplasia and malignant lesions (P < 0.05). CONCLUSION: Dysplasia is a premalignant change of colonic carcinoma. The detection of P21 via immunohistochemistry and AgNOR counting may be an important clinical screening technique for colon carcinoma and premalignant lesions.

  3. Prognostic value of serum CYFRA21-1 and CEA for non-small-cell lung cancer.

    PubMed

    Zhang, Zhi-Hui; Han, Yun-Wei; Liang, Hui; Wang, Le-Min

    2015-11-01

    The aim of the study was to assess the clinical prognostic value of serum cytokeratin 19 fragment (CYFRA21-1) and carcinoembryonic antigen (CEA) for non-small-cell lung cancer (NSCLC) patients. Literatures related to effects of serum CYFRA21-1 and CEA on the prognosis of lung cancer patients were retrieved from databases such as PubMed, Springer Link, Embase, Wanfang, and CNKI. Meta-analysis was carried out using RevMan 5.1 software. Ten literatures involving 1990 NSCLC patients were selected in this study. Total survive estimation merging hazard ratio (HR) in all NSCLC patients with high-level serum CYFRA21-1 was 1.64 (95% CI 1.46-1.84, P < 0.001) and that in all NSCLC patients with high level serum CEA was 1.46 (95% CI 1.28-1.65, P < 0.001). Serum CYFRA21-1 and CEA can be used as prognostic factors of NSCLC patients. Combinative detection of the two indices will be more reliable. PMID:26333429

  4. Prognostic value of serum CYFRA21-1 and CEA for non-small-cell lung cancer

    PubMed Central

    Zhang, Zhi-Hui; Han, Yun-Wei; Liang, Hui; Wang, Le-Min

    2015-01-01

    The aim of the study was to assess the clinical prognostic value of serum cytokeratin 19 fragment (CYFRA21-1) and carcinoembryonic antigen (CEA) for non-small-cell lung cancer (NSCLC) patients. Literatures related to effects of serum CYFRA21-1 and CEA on the prognosis of lung cancer patients were retrieved from databases such as PubMed, Springer Link, Embase, Wanfang, and CNKI. Meta-analysis was carried out using RevMan 5.1 software. Ten literatures involving 1990 NSCLC patients were selected in this study. Total survive estimation merging hazard ratio (HR) in all NSCLC patients with high-level serum CYFRA21-1 was 1.64 (95% CI 1.46–1.84, P < 0.001) and that in all NSCLC patients with high level serum CEA was 1.46 (95% CI 1.28–1.65, P < 0.001). Serum CYFRA21-1 and CEA can be used as prognostic factors of NSCLC patients. Combinative detection of the two indices will be more reliable. PMID:26333429

  5. 77 FR 74181 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-13

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of ISO New England Inc.: NEPOOL...

  6. 78 FR 36183 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-17

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the South Carolina Regional...

  7. 77 FR 11531 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-27

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Midwest Independent Transmission...

  8. 78 FR 4406 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-01-22

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the South Carolina Regional...

  9. 78 FR 36770 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-19

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  10. 77 FR 59184 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-26

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives ] notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services, Inc.:...

  11. 78 FR 32386 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-30

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services,...

  12. 77 FR 63308 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-16

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services,...

  13. 78 FR 24193 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-24

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following joint stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  14. 78 FR 28839 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-16

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following joint stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  15. 77 FR 73645 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services,...

  16. 77 FR 14777 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-13

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services, Inc.:...

  17. 78 FR 21927 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-04-12

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the ] transmission planning activities of the Southern Company Services,...

  18. 78 FR 39728 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-02

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following joint stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  19. 78 FR 18330 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-26

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following joint stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  20. 78 FR 38313 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-26

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following joint stakeholder meeting related to the transmission planning activities of PJM Interconnection,...

  1. 77 FR 21978 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-12

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the...

  2. 75 FR 41451 - Commission Agenda and Priorities; Notice of Hearing

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-07-16

    ... From the Federal Register Online via the Government Publishing Office CONSUMER PRODUCT SAFETY COMMISSION Commission Agenda and Priorities; Notice of Hearing AGENCY: Consumer Product Safety Commission. ACTION: Notice of public hearing. SUMMARY: The Consumer Product Safety Commission (``Commission'')...

  3. 75 FR 52799 - Notice of Public Hearing and Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-27

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Notice of Public Hearing and Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice of public hearing and Commission meeting. SUMMARY: The Susquehanna River Basin Commission...

  4. 75 FR 72857 - Notice of Public Hearing and Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-11-26

    ... From the Federal Register Online via the Government Publishing Office SUSQUEHANNA RIVER BASIN COMMISSION Notice of Public Hearing and Commission Meeting AGENCY: Susquehanna River Basin Commission. ACTION: Notice of public hearing and Commission meeting. SUMMARY: The Susquehanna River Basin Commission...

  5. Commissioning New Construction at Emory University.

    ERIC Educational Resources Information Center

    Smith, Robin

    2001-01-01

    Discusses the process of "commissioning" for effectively maintaining and verifying new construction needs for campus facilities on a continuous improvement basis. The Emory University facility management program illustrates how to develop and manage a building commissioning process. (GR)

  6. Blue Ribbon Commission Tour of Hanford Site

    ScienceCinema

    Paul Saueressig

    2010-09-01

    The Blue Ribbon Commission on America's Nuclear Future toured the Department of Energy's Hanford Site on July 14, 2010. Commission members, invited guests, and members of the public visited facilities that store high-level, radioactive waste.

  7. Division J Commission 28: Galaxies

    NASA Astrophysics Data System (ADS)

    Gallagher, John S.; Davies, Roger L.; Courteau, Stéphane; Dekel, Avishai; Franx, Marijn; Jog, Chanda J.; Jogee, Sardha; Nakai, Naomasa; Rubio, Monica; Tacconi, Linda; Terlevich, Elena

    2016-04-01

    IAU Commission 28 (IAU C28: Galaxies) was founded in the late 1930s at which time it had only a small membership (see the historical notes by Sadler et al. 2007). When C28 ended its existence in 2015 there were well over 1000 members on its books. The membership had grown to the point where the effort to keep track of active participants had become a major task. During the C28s tenure 27 IAU Symposia have been devoted to galaxies, the third highest number (Mickaelian 2014)

  8. Commissioning Instrument for the GTC

    NASA Astrophysics Data System (ADS)

    Cuevas, S.; Sánchez, B.; Bringas, V.; Espejo, C.; Flores, R.; Chapa, O.; Lara, G.; Chavolla, A.; Anguiano, G.; Arciniega, S.; Dorantes, A.; González, J. L.; Montoya, J. M.; Toral, R.; Hernández, H.; Nava, R.; Devaney, N.; Castro, J.; Cavaller-Marqués, L.

    2005-12-01

    During the GTC integration phase, the Commissioning Instrument (CI) will be a diagnostic tool for performance verification. The CI features four operation modes: imaging, pupil imaging, Curvature WFS, and high resolution Shack-Hartmann WFS. This instrument was built by the Instituto de Astronomía UNAM and the Centro de Ingeniería y Desarrollo Industrial (CIDESI) under GRANTECAN contract after a public bid. In this paper we made a general instrument overview and we show some of the performance final results obtained when the Factory Acceptance tests previous to its transport to La Palma.

  9. Nuclear Regulatory Commission 1989 Information Digest

    SciTech Connect

    None,

    1989-03-01

    The Nuclear Regulatory Commission 1989 Information Digest provides summary information regarding the US Nuclear Regulatory Commission, its regulatory responsibilities, and areas licensed by the Commission. This is the first of an annual publication for the general use of the NRC staff and is available to the public. The Digest is divided into two parts: the first presents an overview of the US Nuclear Regulatory Commission and the second provides data on NRC commercial nuclear reactor licensees and commercial nuclear power reactors worldwide.

  10. Bioethics commission to review gene patenting

    SciTech Connect

    Rothenburg, L.

    1995-12-01

    In October, in an unexpected development, U.S. President Bill Clinton created a national ethics advisory board, the National Bioethics Advisory Commission (NBAC, Washington, DC), to study both research ethics and the management and use of genetic information. Of particular interest to biotechnology companies and researchers is the fact that the commission`s brief encompasses issues about human gene patenting, a subject not contained in earlier proposals for the commission.

  11. 77 FR 31605 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-29

    ...This notice sets forth the schedule and proposed agenda of an up- coming meeting of the Equity and Excellence Commission (Commission). The notice also describes the functions of the Commission. Notice of this meeting is required by section 10(a)(2) of the Federal Advisory Committee Act (FACA) and is intended to notify the public of their opportunity to...

  12. 76 FR 41233 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-07-13

    ... Equity and Excellence Commission AGENCY: U.S. Department of Education, Office for Civil Rights. ACTION... meeting of the Equity and Excellence Commission (Commission). The notice also describes the functions of... Center Plaza, 550 12th Street, SW., Washington, DC 20202 in the auditorium (room 10026). FOR...

  13. 46 CFR 502.161 - Commission's files.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 9 2010-10-01 2010-10-01 false Commission's files. 502.161 Section 502.161 Shipping...; Presiding Officers; Evidence § 502.161 Commission's files. Where any matter contained in a tariff, report, or other document on file with the Commission is offered in evidence, such document need not...

  14. 78 FR 44927 - 101st Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-25

    ... From the Federal Register Online via the Government Publishing Office ARCTIC RESEARCH COMMISSION 101st Commission Meeting Notice is hereby given that the U.S. Arctic Research Commission will hold its... presentations concerning Arctic research activities The focus of the meeting will be Arctic research...

  15. 39 CFR 3060.42 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 39 Postal Service 1 2014-07-01 2014-07-01 false Commission review. 3060.42 Section 3060.42 Postal... COMPETITIVE PRODUCTS ENTERPRISE § 3060.42 Commission review. (a) Interested persons shall be provided an... documentation. (b) The Commission will review the calculation of the assumed Federal income tax...

  16. 10 CFR 110.40 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 10 Energy 2 2012-01-01 2012-01-01 false Commission review. 110.40 Section 110.40 Energy NUCLEAR REGULATORY COMMISSION (CONTINUED) EXPORT AND IMPORT OF NUCLEAR EQUIPMENT AND MATERIAL Review of License Applications § 110.40 Commission review. (a) Immediately after receipt of a license application for an...

  17. 76 FR 55424 - CFC-50 Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-07

    ...The U.S. Office of Personnel Management announces the establishment of the CFC-50 Advisory Commission. The Commission shall advise the Director of the U.S. Office of Personnel Management (OPM) on strengthening the integrity, the operation and effectiveness of the Combined Federal Campaign (CFC) to ensure its continued growth and success. The Commission is an advisory committee composed of......

  18. 76 FR 27034 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-05-10

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Equity and Excellence Commission AGENCY: Office for Civil Rights, U.S. Department of Education. ACTION... upcoming meeting of the Equity and Excellence Commission (Commission). The notice also describes...

  19. 76 FR 62394 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Equity and Excellence Commission AGENCY: Office for Civil Rights, U.S. Department of Education. ACTION...-coming meeting of the Equity and Excellence Commission (Commission). The notice also describes...

  20. 47 CFR 1.425 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false Commission action. 1.425 Section 1.425... Proceedings § 1.425 Commission action. The Commission will consider all relevant comments and material of record before taking final action in a rulemaking proceeding and will issue a decision incorporating...

  1. 10 CFR 2.1331 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 1 2010-01-01 2010-01-01 false Commission action. 2.1331 Section 2.1331 Energy NUCLEAR REGULATORY COMMISSION RULES OF PRACTICE FOR DOMESTIC LICENSING PROCEEDINGS AND ISSUANCE OF ORDERS Procedures for Hearings on License Transfer Applications § 2.1331 Commission action. (a) Upon completion of...

  2. 10 CFR 110.113 - Commission action.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 10 Energy 2 2010-01-01 2010-01-01 false Commission action. 110.113 Section 110.113 Energy NUCLEAR... Commission action. (a) Upon completion of a hearing, the Commission will issue a written opinion including... hearing issues; and (4) Take other action, as appropriate....

  3. 75 FR 18469 - April 2010 Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-12

    ...; ] EXECUTIVE OFFICE OF THE PRESIDENT National Commission on Fiscal Responsibility and Reform April 2010...), the National Commission on Fiscal Responsibility and Reform announces the following meeting: Name: National Commission on Fiscal Responsibility and Reform April 2010 Meeting. Time and Date: Tuesday,...

  4. 77 FR 39560 - International Joint Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-03

    ... International Joint Commission International Joint Commission Invites Public Comment on Upper Great Lakes Report The International Joint Commission (IJC) announced today that it is inviting public comment on the final report of its International Upper Great Lakes Study Board, Lake Superior Regulation:...

  5. The Truman Commission's Vision of the Future

    ERIC Educational Resources Information Center

    Hutcheson, Philo A.

    2007-01-01

    Looking back over three centuries of American higher education, one can see both strengths and weaknesses in the changing attitudes toward teaching goals. In this article, the author discusses the Truman Commission's (President Harry Truman appointed the higher education commission in July 1946, and charged the commission members to examine…

  6. 39 CFR 3060.42 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 39 Postal Service 1 2010-07-01 2010-07-01 false Commission review. 3060.42 Section 3060.42 Postal Service POSTAL REGULATORY COMMISSION PERSONNEL ACCOUNTING PRACTICES AND TAX RULES FOR THE THEORETICAL COMPETITIVE PRODUCTS ENTERPRISE § 3060.42 Commission review. (a) Interested persons shall be provided...

  7. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... President pursuant to the provisions of section 3 of Reorganization Plan No. 10 of 1950 (3 CFR, 1949-1953... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be...

  8. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 45 Public Welfare 4 2014-10-01 2014-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or...

  9. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 16 Commercial Practices 2 2013-01-01 2013-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86...

  10. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 16 Commercial Practices 2 2010-01-01 2010-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86...

  11. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... President pursuant to the provisions of section 3 of Reorganization Plan No. 10 of 1950 (3 CFR, 1949-1953... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be...

  12. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... President pursuant to the provisions of section 3 of Reorganization Plan No. 10 of 1950 (3 CFR, 1949-1953... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be...

  13. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 45 Public Welfare 4 2011-10-01 2011-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or...

  14. 45 CFR 2101.10 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 45 Public Welfare 4 2010-10-01 2010-10-01 false The Commission. 2101.10 Section 2101.10 Public... ORGANIZATION General Organization § 2101.10 The Commission. The Commission is composed of seven members, each of whom is appointed by the President and serves for a period of four years or until his or...

  15. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... President pursuant to the provisions of section 3 of Reorganization Plan No. 10 of 1950 (3 CFR, 1949-1953... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be...

  16. 17 CFR 200.10 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... President pursuant to the provisions of section 3 of Reorganization Plan No. 10 of 1950 (3 CFR, 1949-1953... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false The Commission. 200.10 Section... The Commission. The Commission is composed of five members, not more than three of whom may be...

  17. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... 16 Commercial Practices 2 2011-01-01 2011-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86...

  18. 16 CFR 1000.1 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 16 Commercial Practices 2 2014-01-01 2014-01-01 false The Commission. 1000.1 Section 1000.1....1 The Commission. (a) The Consumer Product Safety Commission is an independent regulatory agency formed on May 14, 1973, under the provisions of the Consumer Product Safety Act (Pub. L. 92-573, 86...

  19. 17 CFR 200.63 - Commission opinions.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... 17 Commodity and Securities Exchanges 3 2014-04-01 2014-04-01 false Commission opinions. 200.63 Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.63 Commission opinions. The...

  20. 29 CFR 2204.309 - Commission review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the judge's decision on the fee application, and the Commission may grant such petitions for review or... 29 Labor 9 2013-07-01 2013-07-01 false Commission review. 2204.309 Section 2204.309 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION...

  1. 29 CFR 2204.309 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... the judge's decision on the fee application, and the Commission may grant such petitions for review or... 29 Labor 9 2012-07-01 2012-07-01 false Commission review. 2204.309 Section 2204.309 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION...

  2. 29 CFR 2704.308 - Commission review.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 29 Labor 9 2013-07-01 2013-07-01 false Commission review. 2704.308 Section 2704.308 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF... § 2704.308 Commission review. (a) Either the applicant or the Secretary of Labor may seek review by...

  3. 29 CFR 2704.308 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 29 Labor 9 2014-07-01 2014-07-01 false Commission review. 2704.308 Section 2704.308 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF... § 2704.308 Commission review. (a) Either the applicant or the Secretary of Labor may seek review by...

  4. 29 CFR 2704.308 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 29 Labor 9 2010-07-01 2010-07-01 false Commission review. 2704.308 Section 2704.308 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF... § 2704.308 Commission review. (a) Either the applicant or the Secretary of Labor may seek review by...

  5. 29 CFR 2204.309 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... the judge's decision on the fee application, and the Commission may grant such petitions for review or... 29 Labor 9 2010-07-01 2010-07-01 false Commission review. 2204.309 Section 2204.309 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION...

  6. 29 CFR 2204.309 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... the judge's decision on the fee application, and the Commission may grant such petitions for review or... 29 Labor 9 2014-07-01 2014-07-01 false Commission review. 2204.309 Section 2204.309 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION...

  7. 29 CFR 2204.309 - Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... the judge's decision on the fee application, and the Commission may grant such petitions for review or... 29 Labor 9 2011-07-01 2011-07-01 false Commission review. 2204.309 Section 2204.309 Labor Regulations Relating to Labor (Continued) OCCUPATIONAL SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION...

  8. 29 CFR 2704.308 - Commission review.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 29 Labor 9 2012-07-01 2012-07-01 false Commission review. 2704.308 Section 2704.308 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF... § 2704.308 Commission review. (a) Either the applicant or the Secretary of Labor may seek review by...

  9. 29 CFR 2704.308 - Commission review.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 29 Labor 9 2011-07-01 2011-07-01 false Commission review. 2704.308 Section 2704.308 Labor Regulations Relating to Labor (Continued) FEDERAL MINE SAFETY AND HEALTH REVIEW COMMISSION IMPLEMENTATION OF... § 2704.308 Commission review. (a) Either the applicant or the Secretary of Labor may seek review by...

  10. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... of the licensing and regulatory process, as mandated by the Atomic Energy Act of 1954, as...

  11. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... of the licensing and regulatory process, as mandated by the Atomic Energy Act of 1954, as...

  12. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... of the licensing and regulatory process, as mandated by the Atomic Energy Act of 1954, as...

  13. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... of the licensing and regulatory process, as mandated by the Atomic Energy Act of 1954, as...

  14. 10 CFR 1.11 - The Commission.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... REGULATORY COMMISSION STATEMENT OF ORGANIZATION AND GENERAL INFORMATION Headquarters § 1.11 The Commission. (a) The Nuclear Regulatory Commission, composed of five members, one of whom is designated by the... of the licensing and regulatory process, as mandated by the Atomic Energy Act of 1954, as...

  15. Iowa College Student Aid Commission Case Study

    ERIC Educational Resources Information Center

    Leigh, Rachel A.

    2007-01-01

    The purpose of this descriptive case study was to trace the policy production process of a state agency, the Iowa College Student Aid Commission (Commission), to its function today. This case study relied on a review of federal and state statutes, a news article search, biennium reports of the Commission, and information obtained from the…

  16. The Commission on Magnet® Recognition.

    PubMed

    Moran, Janice W

    2016-09-01

    The American Nurses Credentialing Center (ANCC) Commission on Magnet® Recognition is a voluntary governing body that oversees the Magnet Recognition Program®. Commission members are appointed by the ANCC Board of Directors and are expert representatives from various sectors of the nursing community. In addition, 1 commission member represents public consumers. PMID:27556648

  17. 17 CFR 200.63 - Commission opinions.

    Code of Federal Regulations, 2012 CFR

    2012-04-01

    ... 17 Commodity and Securities Exchanges 2 2012-04-01 2012-04-01 false Commission opinions. 200.63 Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.63 Commission opinions. The...

  18. 17 CFR 200.63 - Commission opinions.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Commission opinions. 200.63 Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.63 Commission opinions. The...

  19. 17 CFR 200.63 - Commission opinions.

    Code of Federal Regulations, 2013 CFR

    2013-04-01

    ... 17 Commodity and Securities Exchanges 2 2013-04-01 2013-04-01 false Commission opinions. 200.63 Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.63 Commission opinions. The...

  20. 17 CFR 200.63 - Commission opinions.

    Code of Federal Regulations, 2011 CFR

    2011-04-01

    ... 17 Commodity and Securities Exchanges 2 2011-04-01 2011-04-01 false Commission opinions. 200.63 Section 200.63 Commodity and Securities Exchanges SECURITIES AND EXCHANGE COMMISSION ORGANIZATION; CONDUCT AND ETHICS; AND INFORMATION AND REQUESTS Canons of Ethics § 200.63 Commission opinions. The...

  1. [Clinical evaluation of the tumor marker CA 19-9 in comparison with carcinoembryonic antigen (CEA) in surgical pre- and postoperative diagnosis].

    PubMed

    Lorenz, M; Happ, J; Hottenrott, C; Maul, F D; Baum, R P; Hör, G; Encke, A

    1986-02-01

    A new tumor marker (CA 19-9) was investigated. CA 19-9 is a tumor-associated antigen which is detected by a monoclonal antibody. CA 19-9 (CIS-Centocor) was compared simultaneously with CEA (carcinoembryonic antigen) in 347 patients. 123 patients with gastrointestinal tumors showed a sensitivity of 31% for CA 19-9 (CEA 49%), combination increased sensitivity to 58%. The highest sensitivity was found in pancreas carcinoma (CA 19-9 75%, CEA 66%, combination 92%); it was lower in gastric, colon, and oesophagus carcinomas. In relapsed colorectal carcinomas sensitivity was 53% (CEA 78%, combination 85%). In cases of relapse, tumor markers may become positive even if they were not detectable before resection of the primary tumor. Specificity for CA 19-9 was 100% (CEA 84%) compared to a group of non-malignant diseases including patients with inflammations and patients with nicotin abuse (n = 102). Because of its high specificity and superior sensitivity to CEA in pancreas carcinomas CA 19-9 should be determined in primary and relapse diagnosis in combination with CEA. PMID:3459133

  2. Binding of insecticidal lectin Colocasia esculenta tuber agglutinin (CEA) to midgut receptors of Bemisia tabaci and Lipaphis erysimi provides clues to its insecticidal potential.

    PubMed

    Roy, Amit; Gupta, Sumanti; Hess, Daniel; Das, Kali Pada; Das, Sampa

    2014-07-01

    The insecticidal potential of Galanthus nivalis agglutinin-related lectins against hemipterans has been experimentally proven. However, the basis behind the toxicity of these lectins against hemipterans remains elusive. The present study elucidates the molecular basis behind insecticidal efficacy of Colocasia esculenta tuber agglutinin (CEA) against Bemisia tabaci and Lipaphis erysimi. Confocal microscopic analyses highlighted the binding of 25 kDa stable homodimeric lectin to insect midgut. Ligand blots followed by LC MS/MS analyses identified binding partners of CEA as vacuolar ATP synthase and sarcoplasmic endoplasmic reticulum type Ca(2+) ATPase from B. tabaci, and ATP synthase, heat shock protein 70 and clathrin heavy chain assembly protein from L. erysimi. Internalization of CEA into hemolymph was confirmed by Western blotting. Glycoprotein nature of the receptors was identified through glycospecific staining. Deglycosylation assay indicated the interaction of CEA with its receptors to be probably glycan mediated. Surface plasmon resonance analysis revealed the interaction kinetics between ATP synthase of B. tabaci with CEA. Pathway prediction study based on Drosophila homologs suggested the interaction of CEA with insect receptors that probably led to disruption of cellular processes causing growth retardation and loss of fecundity of target insects. Thus, the present findings strengthen our current understanding of the entomotoxic potentiality of CEA, which will facilitate its future biotechnological applications. PMID:24753494

  3. Beyond Commissioning: The Role of Automation

    SciTech Connect

    Brambley, Michael R.; Katipamula, Srinivas

    2005-02-01

    This article takes a brief look at the benefits of commissioning and describes a vision of the future where most of the objectives of commissioning will be accomplished automatically by capabilities built into the building systems themselves. Commissioning will become an activity that's performed continuously rather than periodically, and only repairs requiring replacement or overhaul of equipment will require manual intervention. The article then identifies some of the technologies that will be needed to realize this vision and ends with a call for all involved in the enterprise of building commissioning and automation to embrace and dedicate themselves to a future of automated commissioning.

  4. 77 FR 41877 - International Joint Commission; International Joint Commission To Hold Public Hearings on Lake...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-16

    ... International Joint Commission; International Joint Commission To Hold Public Hearings on Lake Osoyoos The International Joint Commission (IJC) is inviting the public to comment on recommendations for the renewal of its... of the International Joint Commission's Osoyoos Lake Order now posted on the IJC Web site at...

  5. Commissioning neuropsychiatry services: barriers and lessons.

    PubMed

    Bhattacharya, Rahul; Rickards, Hugh; Agrawal, Niruj

    2015-12-01

    Aims and method Previous studies have shown variations in commissioning of neuropsychiatry services and this makes access to neuropsychiatric services a post-code lottery. In this survey, we approached all mental health and neuropsychiatric service commissioners within London to map current funding and commissioning arrangements, and explored perceived barriers to neuropsychiatric service commissioning. Results 83% of commissioners within London responded. There was significant variability between neuropsychiatric services commissioned through the mental health stream. Contracting arrangements were variable. Lack of earmarked fund for neuropsychiatry and disjointed funding stream for such services were identified by commissioners as a barrier, as was the critical mass of neuropsychiatric cases. Clinical implications Neuropsychiatric service development continues to be hindered by lack of clear commissioning process. Strategic drive is needed to promote more equitable neuropsychiatric services. National or regional commissioning covering a large population will provide a better model for neuropsychiatric services to be commissioned. PMID:26755989

  6. Commissioning neuropsychiatry services: barriers and lessons

    PubMed Central

    Bhattacharya, Rahul; Rickards, Hugh; Agrawal, Niruj

    2015-01-01

    Aims and method Previous studies have shown variations in commissioning of neuropsychiatry services and this makes access to neuropsychiatric services a post-code lottery. In this survey, we approached all mental health and neuropsychiatric service commissioners within London to map current funding and commissioning arrangements, and explored perceived barriers to neuropsychiatric service commissioning. Results 83% of commissioners within London responded. There was significant variability between neuropsychiatric services commissioned through the mental health stream. Contracting arrangements were variable. Lack of earmarked fund for neuropsychiatry and disjointed funding stream for such services were identified by commissioners as a barrier, as was the critical mass of neuropsychiatric cases. Clinical implications Neuropsychiatric service development continues to be hindered by lack of clear commissioning process. Strategic drive is needed to promote more equitable neuropsychiatric services. National or regional commissioning covering a large population will provide a better model for neuropsychiatric services to be commissioned. PMID:26755989

  7. Commission 19: Rotation of the Earth

    NASA Astrophysics Data System (ADS)

    Brzezinski, Aleksander; Ma, Chopo; Dehant, Véronique; Defraigne, Pascale; Dickey, Jean O.; Huang, Cheng-Li; Souchay, Jean; Vondrák, Jan; Charlot, Patrick; Richter, Bernd; Schuh, Harald

    The Commission supports and coordinates scientific investigations in the Earth rotation and related reference frames. Several changes had been introduced to the structure of Commission 19 since the IAU XXVI General Assembly in Prague, 2006. The Organizing Committee of Commission 19 has been substantially reduced. It consists now of six ex-officio members, the Commission president, vice-president, past president and representatives from the International Association of Geodesy (IAG), International Earth Rotation and Reference Systems Service (IERS), International VLBI Service for Geodesy and Astrometry (IVS), and five members at-large who are nominated by the OC, selected by the Commission members and elected by the IAU GA for a maximum of two terms. The modified terms of reference of Commission 19, the list of members and other details can be found at the Commission website .

  8. Automated Demand Response and Commissioning

    SciTech Connect

    Piette, Mary Ann; Watson, David S.; Motegi, Naoya; Bourassa, Norman

    2005-04-01

    This paper describes the results from the second season of research to develop and evaluate the performance of new Automated Demand Response (Auto-DR) hardware and software technology in large facilities. Demand Response (DR) is a set of activities to reduce or shift electricity use to improve the electric grid reliability and manage electricity costs. Fully-Automated Demand Response does not involve human intervention, but is initiated at a home, building, or facility through receipt of an external communications signal. We refer to this as Auto-DR. The evaluation of the control and communications must be properly configured and pass through a set of test stages: Readiness, Approval, Price Client/Price Server Communication, Internet Gateway/Internet Relay Communication, Control of Equipment, and DR Shed Effectiveness. New commissioning tests are needed for such systems to improve connecting demand responsive building systems to the electric grid demand response systems.

  9. The commissioning of FTS-2

    NASA Astrophysics Data System (ADS)

    AbdElazim, Sherif

    Despite that over half the energy emitted by the universe falls in the sub-millimetre wavelength region, and the fact that sub-millimetre astronomy enables the study of star formation, it remains an unexplored field. This is due to the low transmittance of the atmosphere and the complexity of the instrumentation. However, recent advances in technology have resulted in instruments that can explore this waveband. One such instrument, FTS-2, is a Fourier transform spectrometer that has been developed for use with a new bolometric camera SCUBA-2. FTS-2 will provide wide field imaging spectroscopy at sub-millimetre wavelengths. This thesis presents the current performance of FTS-2 based on the results obtained from commissioning. As with the application with any new technology, unforeseen issues emerged. The thesis identifies several issues and introduces potential solutions. Although limited astronomical data were obtained, spectra of Venus have been analysed, and provide an indication of the potential of FTS-2.

  10. RHIC Spin Flipper Commissioning Status

    SciTech Connect

    Bai, M.; Meot, F.; Dawson, C.; Oddo, P.; Pai, C.; Pile, P.; Makdisi, Y.; Meng, W.; Roser, T.

    2010-05-23

    The commissioning of the RHIC spin flipper in the RHIC Blue ring during the RHIC polarized proton run in 2009 showed the detrimental effects of global vertical coherent betatron oscillation induced by the 2-AC dipole plus 4-DC dipole configuration. This global orbital coherent oscillation of the RHIC beam in the Blue ring in the presence of collision modulated the beam-beam interaction between the two RHIC beams and affected Yellow beam polarization. The experimental data at injection with different spin tunes by changing the snake current also demonstrated that it was not possible to induce a single isolated spin resonance with the global vertical coherent betatron oscillation excited by the two AC dipoles. Hence, a new design was proposed to eliminate the coherent vertical betatron oscillation outside the spin flipper by adding three additional AC dipoles. This paper presents the experimental results as well as the new design.

  11. Division A Commission 31: Time

    NASA Astrophysics Data System (ADS)

    Hosokawa, Mizuhiko; Arias, Elisa Felicitas; Manchester, Richard; Tuckey, Philip; Matsakis, Demetrios; Zhang, Shougang; Zharov, Vladimir

    2016-04-01

    Time is an essential element of fundamental astronomy. In recent years there have been many time-related issues, in scientific and technological aspects as well as in conventions and definitions. At the Commission 31 (Time) business meeting at the XXIX General Assembly, recent progress and many topics, including Pulsar Time Scales WG and Future UTC WG activities, were reviewed and discussed. In this report, we will review the progress of these topics in the past three years. There are many remarkable topics, such as Time scales, Atomic clock development, Time transfer, Future UTC and future redefinition of the second. Among them, scientific highlights are the progress of pulsar time scales and the optical frequency standards. On the other hand, as the social convention, change in the definition of UTC and the second is important.

  12. Orion: a commissioned user facility

    NASA Astrophysics Data System (ADS)

    Treadwell, P. A.; Allan, P.; Cann, N.; Danson, C.; Duffield, S.; Elsmere, S.; Edwards, R.; Egan, D.; Girling, M.; Gumbrell, E.; Harvey, E.; Hill, M.; Hillier, D.; Hoarty, D.; Hobbs, L.; Hopps, N.; Hussey, D.; Oades, K.; James, S.; Norman, M.; Palmer, J.; Parker, S.; Winter, D.; Bett, T.

    2013-05-01

    The Orion Laser Facility at AWE in the UK consists of ten nanosecond beamlines and two sub-picosecond beamlines. The nanosecond beamlines each nominally deliver 500 J at 351 nm in a 1 ns square temporal profile, but can also deliver a user-definable temporal profile with durations between 0.1 ns and 5 ns. The sub-picosecond beamlines each nominally deliver 500 J at 1053 nm in a 500 fs pulse, with a peak irradiance of greater than 1021 W/cm2. One of the sub-picosecond beamlines can also be frequency-converted to deliver 100 J at 527 nm in a 500 fs pulse, although this is at half the aperture of the 1053 nm beam. Commissioning of all twelve beamlines has been completed, including the 527 nm sub-picosecond option. An overview of the design of the Orion beamlines will be presented, along with a summary of the commissioning and subsequent performance data. The design of Orion was underwritten by running various computer simulations of the beamlines. Work is now underway to validate these simulations against real system data, with the aim of creating predictive models of beamline performance. These predictive models will enable the user's experimental requirements to be critically assessed ahead of time, and will ultimately be used to determine key system settings and parameters. The facility is now conducting high energy density physics experiments. A capability experiment has already been conducted that demonstrates that Orion can generate plasmas at several million Kelvin and several times solid density. From March 2013 15% of the facility operating time will be given over to external academic users in addition to collaborative experiments with AWE scientists.

  13. Los Angeles County Juvenile Justice Crime Prevention Act: Fiscal Year 2005-2006. Report Summary

    ERIC Educational Resources Information Center

    Turner, Susan; Fain, Terry; Sehgal, Amber

    2007-01-01

    This document summarizes a study relating to California counties receiving state funds for Juvenile Justice Crime Prevention Act (JJCPA) programs. These counties are required to report six outcome measures to the California State Legislature on an annual basis to measure the success of the program. These outcome measures are (1) successful…

  14. Los Angeles County Juvenile Justice Crime Prevention Act: Fiscal Year 2005-2006 Report

    ERIC Educational Resources Information Center

    Turner, Susan; Fain, Terry; Sehgal, Amber

    2007-01-01

    In 2000, the California State Legislature passed the Schiff-Cardenas Crime Prevention Act, which authorized funding for county juvenile justice programs and designated the Corrections Standards Authority (CSA), formerly named the Board of Corrections, the administrator of funding. California counties receiving state funds for Juvenile Justice…

  15. The Nebraska Center for Research on Children, Youth, Families and Schools. Annual Report, 2005-2006

    ERIC Educational Resources Information Center

    Nebraska Center for Research on Children, Youth, Families and Schools, 2006

    2006-01-01

    The mission of the Nebraska Center for Research on Children, Youth, Families and Schools (CYFS) is to conduct research that improves our understanding of optimal ways that parents, teachers and other service providers in family, school and community contexts can promote the intellectual and socio-emotional development and behavioral adjustment of…

  16. 2005-2006 What We Eat In America, NHANES Tables 1-8

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The Food Surveys Research Group of the Beltsville Human Nutrition Research Center, USDA, conducts the What We Eat in America (WWEIA) survey, the dietary interview component of the National Health and Examination Survey (NHANES). In the survey, dietary intakes are collected yearly from a nationwide s...

  17. Looking for Bemisia tabaci biotype Q in Florida: Results of Biotype sampling from 2005-2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    In March 2005, Arizona scientists identified the Q biotype of Bemisia tabaci from Poinsettia plants that originated from California. Soon after, Florida began forming a plan for surveying, identifying and dealing with the Q biotype. Efforts for surveying began immediately in March 2005 and have cont...

  18. Ground-Water Quality in the Genesee River Basin, New York, 2005-2006

    USGS Publications Warehouse

    Eckhardt, David A.V.; Reddy, J.E.; Tamulonis, Kathryn L.

    2007-01-01

    Water samples were collected from 7 community water system wells and 15 private domestic wells throughout the Genesee River Basin in New York State (downstream from the Pennsylvania border) from October 2005 through March 2006 and analyzed to characterize the chemical quality of ground water in the basin. The wells were selected to represent areas of greatest ground-water use and to provide a representative sampling from the 2,439 square-mile basin area in New York. Samples were analyzed for five physical properties and 226 constituents that included nutrients, major inorganic ions, trace elements, radionuclides, pesticides, volatile organic compounds, and bacteria. The results show that ground water used for drinking water is generally of good quality in the Genesee River Basin, although concentrations of seven constituents exceeded drinking water standards. The cations that were detected in the highest concentrations were calcium, magnesium, and sodium; the anions that were detected in the greatest concentrations were bicarbonate, chloride, and sulfate. The predominant nutrient was nitrate, and nitrate concentrations were greater in samples from sand and gravel aquifers than in samples from bedrock aquifers. The trace elements barium, boron, cobalt, copper, and nickel were detected in every sample; the highest concentrations were barium, boron, chromium, iron, manganese, strontium, and lithium. Fourteen pesticides including seven pesticide degradates were detected in water from 12 of the 22 wells, but none of the concentrations exceeded Maximum Contaminant Levels (MCLs). Eight volatile organic compounds (VOCs) were detected in six samples, but none of the concentrations exceeded MCLs. Seven chemical analytes and three types of bacteria were present in concentrations that exceeded Federal and New York State water-quality standards, which are typically identical. Sulfate concentrations exceeded the U.S. Environmental Protection Agency (USEPA) Secondary Maximum Contaminant Level (SMCL) of 250 milligrams per liter (mg/L) in three samples; the chloride SMCL (250 mg/L) was exceeded in one sample. Sodium concentrations exceeded the USEPA Drinking Water Health Advisory of 60 mg/L in five samples. The SMCL for iron (300 ug/L) was exceeded in 11 filtered samples; the USEPA SMCL for manganese (50 ug/L) was exceeded in 10 filtered samples, and the New York State MCL (300 ug/L) was exceeded in 1 filtered sample. The MCL for aluminum (200 ug/L) was exceeded in 1 sample, and the MCL for arsenic (10 ug/L) was exceeded in 1 sample. Radon-222 exceeded the proposed USEPA MCL of 300 picocuries per liter in 16 samples. Any detection of total coliform or fecal coliform bacteria is considered a violation of New York State health regulations; in this study, total coliform was detected in eight samples; fecal coliform was detected in two samples, and Escherichia coli was detected in one sample.

  19. 7 CFR 760.810 - Qualifying 2005, 2006, or 2007 quantity crop losses.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... the unavailability of equipment, the collapse or failure of equipment, or apparatus used in the honey operation; (3) Resulting from storage of honey after harvest; (4) To honey production because of bee feeding... of buildings or structures. (d) Qualifying losses under this part for honey, where the...

  20. 7 CFR 760.810 - Qualifying 2005, 2006, or 2007 quantity crop losses.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... the unavailability of equipment, the collapse or failure of equipment, or apparatus used in the honey operation; (3) Resulting from storage of honey after harvest; (4) To honey production because of bee feeding... of buildings or structures. (d) Qualifying losses under this part for honey, where the...

  1. 7 CFR 760.810 - Qualifying 2005, 2006, or 2007 quantity crop losses.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... the unavailability of equipment, the collapse or failure of equipment, or apparatus used in the honey operation; (3) Resulting from storage of honey after harvest; (4) To honey production because of bee feeding... of buildings or structures. (d) Qualifying losses under this part for honey, where the...

  2. 7 CFR 760.810 - Qualifying 2005, 2006, or 2007 quantity crop losses.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... the unavailability of equipment, the collapse or failure of equipment, or apparatus used in the honey operation; (3) Resulting from storage of honey after harvest; (4) To honey production because of bee feeding... of buildings or structures. (d) Qualifying losses under this part for honey, where the...

  3. 7 CFR 760.810 - Qualifying 2005, 2006, or 2007 quantity crop losses.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... the unavailability of equipment, the collapse or failure of equipment, or apparatus used in the honey operation; (3) Resulting from storage of honey after harvest; (4) To honey production because of bee feeding... of buildings or structures. (d) Qualifying losses under this part for honey, where the...

  4. Brief report: investigation into recalled human tissue for transplantation--United States, 2005-2006.

    PubMed

    2006-05-26

    On September 29, 2005, a human tissue-processing company discovered inaccuracies in donor records forwarded from a tissue-recovery firm and notified the Food and Drug Administration (FDA). An FDA investigation determined that the recovery firm, Biomedical Tissue Services, Ltd. (BTS) (Fort Lee, New Jersey), recovered tissues from human donors who might not have met donor eligibility requirements and who were not screened properly for certain infectious diseases. In October 2005, BTS and the five processors that had received the tissues, working with FDA, issued a recall for all tissues recovered by BTS. The continuing FDA investigation determined that information for some donors (e.g., cause, place, or time of death) was not consistent with death certificate data obtained from the states where the deaths occurred. The investigation also determined that BTS had failed to recover tissues in a manner that would prevent contamination or cross-contamination and failed to control environmental conditions adequately during tissue recovery. These failures were violations of the Current Good Tissue Practice Rules (effective May 25, 2005), which require manufacturers to recover, process, store, label, package, and distribute human cells, tissue, and cellular and tissue-based products (HCT/Ps) to prevent introduction, transmission, or spread of communicable diseases. In January 2006, FDA ordered BTS to cease manufacturing and to retain all HCT/Ps. PMID:16723969

  5. Snacking Patterns of U.S. Adolescents: What We Eat In America, NHANES 2005-2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The goals of this study were to track changes in snacking frequency over time, determine whether snacking is associated with food energy intake and body mass index (BMI), and measure the contribution of snacks to overall intakes of nutrients and MyPyramid food groups. Twenty-four hour dietary recall...

  6. Habitat Evaluation Procedures (HEP) Report Wanaket Wildlife Area, Techical Report 2005-2006.

    SciTech Connect

    Ashley, Paul

    2006-02-01

    The Regional HEP Team (RHT) and Confederated Tribes of the Umatilla Indian Reservation (CTUIR) Wildlife Program staff conducted a follow-up habitat evaluation procedures (HEP) analysis on the Wanaket Wildlife Management Area in June 2005. The 2005 HEP investigation generated 3,084.48 habitat units (HUs) for a net increase of 752.18 HUs above 1990/1995 baseline survey results. The HU to acre ratio also increased from 0.84:1.0 to 1.16:1.0. The largest increase in habitat units occurred in the shrubsteppe/grassland cover type (California quail and western meadowlark models), which increased from 1,544 HUs to 2,777 HUs (+43%), while agriculture cover type HUs were eliminated because agricultural lands (managed pasture) were converted to shrubsteppe/grassland. In addition to the agriculture cover type, major changes in habitat structure occurred in the shrubsteppe/grassland cover type due to the 2001 wildfire which removed the shrub component from well over 95% of its former range. The number of acres of all other cover types remained relatively stable; however, habitat quality improved in the riparian herb and riparian shrub cover types. The number and type of HEP species models used during the 2005 HEP analysis were identical to those used in the 1990/1995 baseline HEP surveys. The number of species models employed to evaluate the shrubsteppe/grassland, sand/gravel/mud/cobble, and riparian herb cover types, however, were fewer than reported in the McNary Dam Loss Assessment (Rassmussen and Wright 1989) for the same cover types.

  7. 78 FR 50113 - Distribution of 2004, 2005, 2006, 2007, 2008, and 2009 Cable Royalty Funds

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-08-16

    ... September 16, 2013. ADDRESSES: Participants must submit an original, five paper copies, and an electronic..., music, etc.). For broadcast years 2006 through 2009, the parties settled their controversies. The...

  8. The Student Guide: Financial Aid from the U.S. Department of Education, 2005-2006

    ERIC Educational Resources Information Center

    US Department of Education, 2005

    2005-01-01

    This student guide provides financial aid information for high school seniors and college students. The first few pages of this guide are a quick reference to federal student aid programs and how to apply. Most student financial aid comes from the federal government programs, which the U.S. Department of Education's Federal Student Aid (FSA)…

  9. Professional Development. The Evaluation Exchange. Volume 11, Number 4, Winter 2005-2006

    ERIC Educational Resources Information Center

    DeDeo, Carrie-Anne, Ed.

    2006-01-01

    This issue hones in on professional development in four key sectors affecting children, youth, and families--K-12 education, early childhood education, child welfare, and youth development. Though these sectors face many of the same professional development challenges, each has its own unique issues, strengths, and goals. The staffing shortage in…

  10. Patterns of adult stepping cadence in the 2005-2006 NHANES

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Laboratory studies of adult walking behavior have consistently found that a cadence of 100 steps/min is a reasonable threshold for moderate intensity. The purpose of this study was to determine cadence patterns in free-living adults, and in particular, time spent at increasing cadence increments inc...

  11. Dworshak Kokanee Population and Entrainment Assessment 2005-2006 Annual Report.

    SciTech Connect

    Stark, Eric J.

    2008-11-06

    During this contract, we continued testing underwater strobe lights to determine their effectiveness at repelling kokanee Oncorhynchus nerka away from Dworshak Dam. We tested one set of nine strobe lights flashing at a rate of 360 flashes/min in front of turbine 3 while operating at higher discharges than previously tested. The density and distribution of fish, (thought to be mostly kokanee), were monitored with a split-beam echo sounder. We then compared fish counts and densities during nights when the lights were flashing to counts and densities during adjacent nights without the lights on. On five nights between January 31 and February 28, 2006, when no lights were present, fish counts near turbine 3 averaged eight fish and densities averaged 91 fish/ha. When strobe lights were turned on during five adjacent nights during the same period, mean counts dropped to four fish and densities dropped to 35 fish/ha. The decline in counts (49%) was not statistically significant (p = 0.182), but decline in densities (62%) was significant (p = 0.049). There appeared to be no tendency for fish to habituate to the lights during the night. Test results indicated that strobe lights were able to reduce fish densities by at least 50% in front of turbines operating at higher discharges, which would be sufficient to improve sportfish harvest. We also used split-beam hydroacoustics to monitor the kokanee population in Dworshak Reservoir during 2005. Estimated abundance of kokanee decreased from the 2004 population estimate. Based on hydroacoustic surveys, we estimated 3,011,626 kokanee (90% CI {+-} 15.2%) in Dworshak Reservoir, July 2005. This included 2,135,986 age-0 (90% CI {+-} 15.9%), 769,175 age-1 (90% CI {+-} 16.0%), and 107,465 age-2 (90% CI {+-} 15.2%). Poor survival of kokanee from age-1 to age-2 continued to keep age-2 densities below the management goal of 30-50 adults/ha. Entrainment sampling was conducted with fixed-site split-beam hydroacoustics a minimum of two days per month for a continuous 24 h period when dam operations permitted. The highest fish detection rates from entrainment assessments were again found during nighttime periods and lowest during the day. Fish detection rates were low during high discharges throughout the spring and summer and highest during low discharges in September and November. High discharge during drawdowns for anadromous fish flows in July and August again resulted in low detection rates and susceptibility to entrainment. Index counts of spawning kokanee in four tributary streams totaled 12,742 fish. This data fits the previously developed relationship between spawner counts and adult kokanee abundance in the reservoir.

  12. Prehospital and hospital delays after stroke onset--United States, 2005-2006.

    PubMed

    2007-05-18

    Each year approximately 700,000 persons in the United States have a new or recurrent stroke; of these persons, 15%-30% become permanently disabled, and 20% require institutionalization during the first 3 months after the stroke. The severity of stroke-related disability can be reduced if timely and appropriate treatment is received. Patients with ischemic stroke may be eligible for treatment with intravenous thrombolytic (i.e., tissue plasminogen activator [t-PA]) therapy within 3 hours of symptom onset. Receipt of this treatment usually requires patients to recognize stroke symptoms and receive prompt transport to a hospital emergency department (ED), where timely evaluation and brain imaging (i.e., computed tomography or magnetic resonance imaging) can take place. For patients eligible for t-PA, evidence suggests that the earlier patients are treated after the onset of symptoms the greater the likelihood of a more favorable outcome. In 2001, Congress established the Paul Coverdell National Acute Stroke Registry to measure and track the quality of care provided to acute stroke patients. To assess prehospital delays from onset of stroke symptoms to ED arrival and hospital delays from ED arrival to receipt of brain imaging, CDC analyzed data from the four states participating in the national stroke registry. The results of that analysis indicated that fewer than half (48.0%) of stroke patients for whom onset data were available arrived at the ED within 2 hours of symptom onset, and prehospital delays were shorter for persons transported to the ED by ambulance (i.e., emergency medical services) than for persons who did not receive ambulance transport. The interval between ED arrival and brain imaging also was significantly reduced for those arriving by ambulance. More extensive public education is needed regarding early recognition of stroke and the urgency of telephoning 9-1-1 to receive ambulance transport. Shortening prehospital and hospital delays will increase the proportion of ischemic stroke patients who are eligible to receive t-PA therapy and reduce their risk for severe disability from stroke. PMID:17510611

  13. Western Pond Turtle Head-starting and Reintroduction, 2005-2006 Annual Report.

    SciTech Connect

    Van Leuven, Susan; Allen, Harriet; Slavens, Kate

    2006-11-01

    This report covers the results of the western pond turtle head-starting and reintroduction project for the period of October 2005-September 2006. Wild hatchling western pond turtles from the Columbia River Gorge were reared at the Woodland Park and Oregon zoos in 2005 and 2006 as part of the recovery effort for this Washington State endangered species. The objective of the program is to reduce losses to introduced predators like bullfrogs and largemouth bass by raising the hatchlings to a size where they are too large to be eaten by most of these predators. Twenty-six turtles were placed at the Woodland Park Zoo and 62 at the Oregon Zoo in fall 2005. These turtles joined two that were held back from release in summer 2005 due to their small size. All 90 juvenile turtles were released at three sites in the Columbia Gorge in 2006. Twenty-eight juvenile turtles were released at the Klickitat ponds, 22 at the Klickitat lake, 21 at the Skamania site, and 19 at Pierce National Wildlife Refuge (NWR). This brought the total number of head-start turtles released since 1991 to 944; 285 for the Klickitat ponds, 158 for the Klickitat lake, 227 for the Skamania pond complex, and 274 at Pierce NWR. In 2006, 20 females from the Klickitat population were equipped with transmitters and monitored for nesting activity. Fifteen nests were located and protected; these produced 55 hatchlings. The hatchlings were collected in September and transported to the Oregon and Woodland Park zoos for rearing in the head-start program. One wild hatchling captured in spring 2006 was placed in the head-start program to attain more growth in captivity. During the 2006 field season trapping effort, 414 western pond turtles were captured in the Columbia Gorge, including 374 previously head-started turtles. These recaptures, together with confirmed nesting by head-start females and visual resightings, indicate the program is succeeding in boosting juvenile recruitment to increase the populations. Records were also collected on 179 individual painted turtles captured in 2006 during trapping efforts at Pierce NWR, to gather baseline information on this native population.

  14. Guidelines for Charter School Annual Reports, 2005-2006 School Year

    ERIC Educational Resources Information Center

    Massachusetts Department of Education, 2005

    2005-01-01

    The Annual Report is a critical document in charter school accountability; it is intended to be a clear, concise report regarding school performance and its success in meeting Accountability Plan goals. The formatting for each school's report may be unique; however, there are required elements set forth in this document that must be included in…

  15. Profiles of For-Profit Education Management Organizations: Eighth Annual Report, 2005-2006

    ERIC Educational Resources Information Center

    Molnar, Alex; Garcia, David R.; Bartlett, Margaret; O'Neill, Adrienne

    2006-01-01

    This annual report, in its eighth edition, found that after several years of growth, the EMO (Education Management Organization) industry appears to be entering a period of reconfiguration. In this year's "Profiles", the number of companies listed and the number of schools they manage are down slightly; student enrollment in EMO-managed schools…

  16. 7 CFR 760.817 - Quality losses for 2005, 2006, and 2007 crops.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760..., assistance will be made available to participants determined eligible under this section for crop quality losses of 25 percent or greater of the value that all affected production of the crop would have had...

  17. 7 CFR 760.817 - Quality losses for 2005, 2006, and 2007 crops.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ..., DEPARTMENT OF AGRICULTURE SPECIAL PROGRAMS INDEMNITY PAYMENT PROGRAMS 2005-2007 Crop Disaster Program § 760..., assistance will be made available to participants determined eligible under this section for crop quality losses of 25 percent or greater of the value that all affected production of the crop would have had...

  18. Restore McComas Meadows; Meadow Creek Watershed, 2005-2006 Annual Report.

    SciTech Connect

    McRoberts, Heidi

    2006-07-01

    The Nez Perce Tribe Department of Fisheries Resource Management, Watershed Division approaches watershed restoration with a ridge-top to ridge-top approach. Watershed restoration projects within the Meadow Creek watershed are coordinated and cost shared with the Nez Perce National Forest. The Nez Perce Tribe began watershed restoration projects within the Meadow Creek watershed of the South Fork Clearwater River in 1996. Progress has been made in restoring the watershed by excluding cattle from critical riparian areas through fencing, planting trees in riparian areas within the meadow and its tributaries, prioritizing culverts for replacement to accommodate fish passage, and decommissioning roads to reduce sediment input. During this contract period work was completed on two culvert replacement projects; Doe Creek and a tributary to Meadow Creek. Additionally construction was also completed for the ditch restoration project within McComas Meadows. Monitoring for project effectiveness and trends in watershed conditions was also completed. Road decommissioning monitoring, as well as stream temperature, sediment, and discharge were completed.

  19. Clearwater Focus Watershed; Nez Perce Tribe, 2005-2006 Annual Report.

    SciTech Connect

    Jones, Ira; McRoberts, Heidi

    2006-12-01

    The Nez Perce Tribe Department of Fisheries Resource Management, Watershed Division, approaches watershed restoration with a goal to protect, restore, and enhance a connected network of functioning habitat types capable of supporting all fish life stages. The key objective of the Nez Perce Tribe Focus Coordinator position is to overcome fragmentation within the basin by managing communications with the subbasin, providing an overall framework and process for coordinated fisheries restoration and managing the planning, assessment, implementation, and monitoring and evaluation process. The Nez Perce Tribe began watershed restoration projects within the Clearwater River Subbasin in 1996. Progress has been made in restoring the sub-basin by excluding cattle from critical riparian areas through fencing, stabilizing stream banks, decommissioning roads, restoring fish passage, as well as other watershed restoration projects. Coordination of these projects is critical to the success of the restoration of the sub-basin. Coordination activities also includes: inter and intra-department coordination, sub-basin assessment and planning, involving government and private organizations, and treaty area coordination.

  20. HIV-related behaviors among men who have sex with men in China: 2005-2006.

    PubMed

    Lau, Joseph T F; Wang, Ming; Tse, Yee Kit; Gu, Jing; Tsui, Hi Yi; Zhang, Yun; Wang, Ning; Cheng, Feng

    2009-08-01

    Respectively, 387 and 316 men who have ever had anal or oral sex with men (MSM) in Kunming, China, were interviewed in 2005 and 2006. In both surveys, over 85% reported having had anal sex with noncommercial male sex partners; around 60% had ever had female sex partners; and about 16% engaged in commercial anal sex in the last 6 months. The prevalence of unprotected anal sex decreased over time (last episode of anal sex with noncommercial MSM partner: 37.7% (2005) versus 21.9% (2006) (Adjusted odds ratio [OR] = 0.43); last episode of anal sex with commercial MSM partner, 20.8% (2005) versus 10.8% (2006) (Adjusted OR = 0.50). Some behavioral changes may have occurred. Multivariate analyses showed that study year (OR = 2.24), age (OR = 1.64), marital status (OR = 2.07), and perceived infectivity related to unprotected sex with people living with HIV/AIDS (OR = 0.3) were associated with condom use in the last episode of anal sex with noncommercial MSM partners. PMID:19670968

  1. Occurrence of azoxystrobin, propiconazole, and selected other fungicides in US streams, 2005-2006

    USGS Publications Warehouse

    Battaglin, William A.; Sandstrom, Mark W.; Kuivila, Kathryn M.; Kolpin, Dana W.; Meyer, Michael T.

    2011-01-01

    Fungicides are used to prevent foliar diseases on a wide range of vegetable, field, fruit, and ornamental crops. They are generally more effective as protective rather than curative treatments, and hence tend to be applied before infections take place. Less than 1% of US soybeans were treated with a fungicide in 2002 but by 2006, 4% were treated. Like other pesticides, fungicides can move-off of fields after application and subsequently contaminate surface water, groundwater, and associated sediments. Due to the constant pressure from fungal diseases such as the recent Asian soybean rust outbreak, and the always-present desire to increase crop yields, there is the potential for a significant increase in the amount of fungicides used on US farms. Increased fungicide use could lead to increased environmental concentrations of these compounds. This study documents the occurrence of fungicides in select US streams soon after the first documentation of soybean rust in the US and prior to the corresponding increase in fungicide use to treat this problem. Water samples were collected from 29 streams in 13 states in 2005 and/or 2006, and analyzed for 12 target fungicides. Nine of the 12 fungicides were detected in at least one stream sample and at least one fungicide was detected in 20 of 29 streams. At least one fungicide was detected in 56% of the 103 samples, as many as five fungicides were detected in an individual sample, and mixtures of fungicides were common. Azoxystrobin was detected most frequently (45% of 103 samples) followed by metalaxyl (27%), propiconazole (17%), myclobutanil (9%), and tebuconazole (6%). Fungicide detections ranged from 0.002 to 1.15 μ/L. There was indication of a seasonal pattern to fungicide occurrence, with detections more common and concentrations higher in late summer and early fall than in spring. At a few sites, fungicides were detected in all samples collected suggesting the potential for season-long occurrence in some streams. Fungicide occurrence appears to be related to fungicide use in the associated drainage basins; however, current use information is generally lacking and more detailed occurrence data are needed to accurately quantify such a relation. Maximum concentrations of fungicides were typically one or more orders of magnitude less than current toxicity estimates for freshwater aquatic organisms or humans; however, gaps in current toxicological understandings of the effects of fungicides in the environment limit these interpretations.

  2. The Condition of Higher Education in New Mexico, 2005-2006

    ERIC Educational Resources Information Center

    New Mexico Higher Education Department, 2006

    2006-01-01

    This document reports on data collected by the New Mexico Higher Education Department, providing the status of higher education as of the Fall 2005 semester and makes comparisons to prior year data to calculate change rates. The emphasis of the New Mexico Higher Education Department is to create policy to improve access to educational…

  3. Dengue virus 3 genotype I in Aedes aegypti mosquitoes and eggs, Brazil, 2005-2006.

    PubMed

    Vilela, Ana P P; Figueiredo, Leandra B; dos Santos, João R; Eiras, Alvaro E; Bonjardim, Cláudio A; Ferreira, Paulo C P; Kroon, Erna G

    2010-06-01

    Dengue virus type 3 genotype I was detected in Brazil during epidemics in 2002-2004. To confirm this finding, we identified this virus genotype in naturally infected field-caught Aedes aegypti mosquitoes and eggs. Results showed usefulness of virus investigations in vectors as a component of active epidemiologic surveillance. PMID:20507754

  4. Combined electromagnetic, geochemical and thermal surveys of Taal volcano (Philippines) during the period 2005-2006

    NASA Astrophysics Data System (ADS)

    Zlotnicki, J.; Sasai, Y.; Toutain, J. P.; Villacorte, E. U.; Bernard, A.; Sabit, Julio P.; Gordon, Juan M.; Corpuz, Ernesto G.; Harada, M.; Punongbayan, J. T.; Hase, H.; Nagao, T.

    2009-01-01

    Since 1572, 33 phreatic to phreatomagmatic eruptions have occurred on Taal volcano (Philippines), some of them causing several hundred casualties. Considering the time delay between two consecutive eruptions, there is an 88% probability that Taal volcano should have already erupted. Since 1992, several phases of seismic activity have been recorded accompanied by ground deformation, opening of fissures, and surface activity. The volcanic activity of Taal appears to be controlled by dike injections and magma supply, buffered by a hydrothermal system that releases fluids and heat through boiling and subsequent steaming. In early 2005, a multidisciplinary project was launched for studying the hydrothermal activity. To map the hydrothermal system, combined surveys were carried out to investigate self-potential, total magnetic field, ground temperature and carbon dioxide soil degassing, along with satellite thermal imaging of the Main Crater Lake. The elevated temperatures and high concentrations of carbon dioxide, as well as electromagnetic anomalies, indicate large-scale hydrothermal degassing. This process is enhanced along the tectonic features (e.g., crater rim and faults) of the volcano, while active fissures opened along the E-W northern flank during the 1992-1994 seismic activity. Heat and fluids from the hydrothermal system are essentially released in the northern part of the crater, which is bounded to the South by a suspected NW-SE fault along which seismicity seems to take place, and dikes are thought to be intruded. During the January 2005 surveys, a new seismic crisis started, and the felt earthquakes prompted spontaneous evacuation of hundreds of inhabitants living on the volcano. Repeated surveys show changes of self-potential, total magnetic field, and ground temperature with time, without any noticeable spatial enlargement. These observations suggest that the northern flank located between the crater rim and the 1992-1994 fissures is connected with a deep thermal source in Main crater and is reactivated during seismic crises. This sector could be subjected to flank failure.

  5. [Chikungunya, La Réunion and Mayotte, 2005-2006: an epidemic without a story?].

    PubMed

    Flahault, Antoine; Aumont, Gilles; Boisson, Véronique; de Lamballerile, Xavier; Favier, François; Fontenille, Didier; Gaüzère, Bernard-Alex; Journeaux, Sophie; Lotteau, Vincent; Paupy, Christophe; Sanquer, Marie-Anne; Setbon, Michel

    2007-01-01

    Many triggering factors for onset of emerging infectious diseases are now recognised, such as: globalisation, demographic increase, population movements, international trade, urbanisation, forest destruction, climate changes, loss in biodiversity, and extreme life conditions such as poverty, famine and war. Epidemic burden is often leading to disasters, in terms of human losses, as well as economic, political or social consequences. These outbreaks may jeopardize within a few weeks or months, industry, trade, or tourism. While dengue and its most severe forms (hemorrhagic and shock syndrome) is spreading all over the tropical world, another arbovirosis, chikungunya disease dramatically spread in Indian Ocean islands where 30 to 75% of population were infected in 2005 and 2006, and then extended its progression towards India, Sri Lanka, Indonesia, Malaysia, Maldives islands with more than a million people infected with the East-African strain, replacing the former Asian strain which was known to prevail more than 30 years ago in India. Patients experience sequelae with disability, work loss, and rarely severe outcome recently identified in La Réunion and Mayotte (French overseas territories). No country, no part of the world may consider itself as protected against such events. However, consequences of emerging or re-emerging diseases are more and more unacceptable when they impact the poorest countries of the world. Viruses, bacteria, as well as wild animals, birds, or arthropods are not stopped by borders. It is time now to promote barriers against infectious diseases, including prevention, anticipation, disease surveillance and research. This is not only for humanitarian reasons, but also for contributing to a sustainable development with equity for worldwide population. This report presents comprehensive actions taken in 2006 for tracing the epidemic and mobilise research, as requested to the task force set up by the Prime Minister by March 20, 2006. PMID:17929405

  6. [Emerging infectious diseases: the example of the Indian Ocean chikungunya outbreak (2005-2006)].

    PubMed

    Flahault, Antoine

    2007-01-01

    Factors known to trigger the emergence or re-emergence of infectious diseases include globalisation, population growth, migration, international trade, urbanisation, forest destruction, climate change, loss of biodiversity, poverty, famine and war. Epidemics not only lead to disastrous loss of human life but may also have catastrophic economic, political and social consequences. Outbreaks may rapidly jeopardize industry, trade or tourism in countries that are unprepared. Dengue is currently spreading throughout the tropics, while another arbovirus, chikungunya, infected 30 to 75% of the population in some parts of the Indian Ocean region between 2005 and 2006. Chikungunya is now spreading through India, where more than a million people have so far been infected. This viral disease can cause lasting disability, and the first deaths were recently reported in La Réunion and Mayotte. All countries are at risk from emerging or re-emerging diseases, but the consequences are far worse in poor countries. Microbial pathogens and wild mammals, birds and arthropods do not respect man-made borders. There is still time to act against this threat of emerging and re-emerging infectious diseases, through prevention, anticipation, monitoring and research. PMID:17645111

  7. Monitoring of Downstream Salmon and Steelhead at Federal Hydroelectric Facilities, 2005-2006 Annual Report.

    SciTech Connect

    Martinson, Rick D.; Kovalchuk, Gregory M.; Ballinger, Dean

    2006-04-01

    2005 was an average to below average flow year at John Day and Bonneville Dams. A large increase in flow in May improved migration conditions for that peak passage month. Spill was provided April through August and averaged about 30% and 48% of river flow at John Day and Bonneville Dams, respectively. Water temperature graphs were added this year that show slightly lower than average water temperature at John Day and slightly higher than average temperatures at Bonneville. The number of fish handled at John Day decreased from 412,797 in 2004 to 195,293 this year. Of the 195,293 fish, 120,586 (61.7%) were collected for researchers. Last year, 356,237 (86.3%) of the fish sampled were for researchers. This dramatic decline is the result of (1) fewer research fish needed (2) a smaller, lighter tag which allowed for tagging of smaller fish, and (3) a larger average size for subyearling chinook. These factors combined to reduce the average sample rate to 10.8%, about half of last year's rate of 18.5%. Passage timing at John Day was similar to previous years, but the pattern was distinguished by larger than average passage peaks for spring migrants, especially sockeye. The large spike in mid May for sockeye created a very short middle 80% passage duration of just 16 days. Other spring migrants also benefited from the large increase in flow in May. Descaling was lower than last year for all species except subyearling chinook and below the historical average for all species. Conversely, the incidence of about 90% of the other condition factors increased. Mortality, while up from last year for all species and higher than the historical average for all species except sockeye, continued to be low, less than 1% for all species. On 6 April a slide gate was left closed at John Day and 718 fish were killed. A gate position indicator light was installed to prevent reoccurrences. Also added this year was a PIT tag detector on the adult return-to-river flume. For the first time this year, we successfully held Pacific lamprey ammocetes. The number of fish sampled at Bonneville Dam was also down this year to 260,742, from 444,580 last year. Reasons for the decline are the same as stated above for John Day. Passage timing at Bonneville Dam was quite similar to previous years with one notable exception, sockeye. Sockeye passage was dominated by two large spikes in late May that greatly condensed the passage pattern, with the middle 80% passing Bonneville in just 18 days. Unlike John Day, passage for the rest of the species was well disbursed from late April through early June. Fish condition was good, with reductions in descaling rates for all species except unclipped steelhead and sockeye. Sockeye mortality matched last year's rate but was considerably lower for all other species. Rare species sampled at Bonneville this year included a bull trout and a eulachon.

  8. Lower Granite Dam Smolt Monitoring Program, 2005-2006 Annual Report.

    SciTech Connect

    Mensik, Fred; Rapp, Shawn; Ross, Doug

    2007-01-01

    The 2005 fish collection season at Lower Granite Dam (LGR) was characterized by average water temperatures, below average flows, above average spill, low levels of debris and the record number of smolts collected compared to the previous five years. With the continued release of unclipped supplementation chinook and steelhead above LGR, we cannot accurately distinguish wild chinook, steelhead, and sockeye/kokanee in the sample. For the purposes of this report we will designate fish as clipped and unclipped. This season a total of 13,030,967 juvenile salmonids were collected at LGR. Of these, 12,099,019 were transported to release sites below Bonneville Dam, 12,032,623 by barge and 66,396 by truck. An additional 898,235 fish were bypassed to the river due to over-capacity of the raceways, barges or trucks and for research purposes. This was the first season of summer spill at LGR. Spill was initiated at 12:01am June 20 as directed by the ruling set forth by Judge James Redden of the United States District Court (Order CV 01-640-RE). In addition, the Lower Granite project also conducted a summer spill test alternating spill and spill patterns between spill to the gas cap without the removable spillway weir (RSW) and spill with up to 20 kcfs utilizing the RSW. Because of the forecast low flow this year, most hatchery reared subyearling fall chinook were released up to three weeks early. With the unexpected high flows in late May and early June, more than 90% of the subyearling chinook were collected prior to the initiation of the court ordered summer spill program. Collection number fluctuations reflect river flow and project operations for any given year. For example, low flow years (2001, 2004 and 2005) result in higher collection numbers. Court ordered spill throughout the summer migration will directly affect collection of fall subyearling chinook collection numbers. The editors of this report urge the reader to use caution when comparing fish collection numbers between years, considering both annual river flows and annual project operations, because both affect fish migration and collection.

  9. PBS TeacherLine National Survey of Teacher Professional Development, 2005-2006

    ERIC Educational Resources Information Center

    Hezel Associates (NJ1), 2007

    2007-01-01

    PBS TeacherLine, an initiative funded under the U.S. Department of Education's Ready To Teach program, is designed to provide high-quality online professional development for K-12 teachers. Through the first five-year grant cycle, ending in 2005, PBS TeacherLine produced approximately 100 online facilitated courses in reading, mathematics,…

  10. Fluid milk consumption in the United States: What We Eat In America, NHANES 2005-2006

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The goals of this study were to describe fluid milk consumption patterns of the U.S. population and to determine the impact of fluid milk on daily nutrient intakes. Twenty-four hour dietary recall data from 8,145 children and adults 2 years of age and older participating in What We Eat In America (...

  11. EdTrAc Teacher Education Program: First-Year Implementation Evaluation (2005-2006)

    ERIC Educational Resources Information Center

    Pittman, Brian; Shelton, Ellen

    2006-01-01

    The Educational Training Academy (EdTrAc) is an NSF-funded project of Normandale Community College to increase the number, diversity, and skills of students preparing to be elementary and middle school teachers with a specialty in math and science. Overall, this evaluation indicates that the EdTrAc implementation is on track after its first year…

  12. Arkansas Department of Education Programs for Language Minority Students, 2005-2006

    ERIC Educational Resources Information Center

    Arkansas Department of Education, 2006

    2006-01-01

    Families whose native language is not English have been arriving in Arkansas seeking employment in agriculture-related and other industries. School-age children from these families are relatively new to most of Arkansas school districts, and the educational programs necessary to meet their needs in many school districts are relatively new. Over…

  13. John Day River Subbasin Fish Habitat Enhancement Project, 2005-2006 Annual Report.

    SciTech Connect

    Powell, Russ M.; Alley, Pamela D.; Delano, Kenneth H.

    2006-03-01

    Work undertaken in 2005 included: (1) Four new fence projects were completed thereby protecting 7.55 miles of stream with 9.1 miles of new riparian fence (2) Fence removal 1.7 miles of barbed wire. (3) Completed three spring developments (repair work on two BLM springs on Cottonwood Creek (Dayville), 1 solar on Rock Creek/ Collins property). (4) Dredge tail leveling completed on 0.9 miles of the Middle Fork of the John Day River (5) Cut, hauled and placed 30 junipers on Indian Creek/Kuhl property for bank stability. (6) Collected and planted 1500 willow cuttings on Mountain Creek/Jones property. (7) Conducted steelhead redd counts on Lake Cr./Hoover property and Cottonwood Cr./Mascall properties (8) Seeded 200 lbs of native grass seed on projects where the sites were disturbed by fence construction activities. (9) Maintenance of all active project fences (72.74 miles), watergaps (60), spring developments (30) were checked and repairs performed. (10) Since the initiation of the Fish Habitat Program in 1984 we have installed 156.06 miles of riparian fence on leased property protecting 88.34 miles of anadromous fish bearing stream. With the addition of the Restoration and Enhancement Projects from 1996-2001, where the landowner received the materials, built and maintained the project we have a total of 230.92 miles of fence protecting 144.7 miles of stream and 3285 acres of riparian habitat.

  14. Lower Granite Dam Smolt Monitoring Program, Annual Report 2005-2006.

    SciTech Connect

    Menski, Fred

    2007-01-01

    The 2005 fish collection season at Lower Granite Dam (LGR) was characterized by average water temperatures, below average flows, above average spill, low levels of debris and the record number of smolts collected compared to the previous five years. With the continued release of unclipped supplementation chinook and steelhead above LGR, we cannot accurately distinguish wild chinook, steelhead, and sockeye/kokanee in the sample. For the purposes of this report we will designate fish as clipped and unclipped. This season a total of 13,030,967 juvenile salmonids were collected at LGR. Of these, 12,099,019 were transported to release sites below Bonneville Dam, 12,032,623 by barge and 66,396 by truck. An additional 898,235 fish were bypassed to the river due to over-capacity of the raceways, barges or trucks and for research purposes. This was the first season of summer spill at LGR. Spill was initiated at 12:01am June 20 as directed by the ruling set forth by Judge James Redden of the United States District Court (Order CV 01-640-RE). In addition, the Lower Granite project also conducted a summer spill test alternating spill and spill patterns between spill to the gas cap without the removable spillway weir (RSW) and spill with up to 20 kcfs utilizing the RSW. Because of the forecast low flow this year, most hatchery reared subyearling fall chinook were released up to three weeks early. With the unexpected high flows in late May and early June, more than 90% of the subyearling chinook were collected prior to the initiation of the court ordered summer spill program. Collection number fluctuations reflect river flow and project operations for any given year. For example, low flow years (2001, 2004 and 2005) result in higher collection numbers. Court ordered spill throughout the summer migration will directly affect collection of fall subyearling chinook collection numbers. The editors of this report urge the reader to use caution when comparing fish collection numbers between years, considering both annual river flows and annual project operations, because both affect fish migration and collection.

  15. Duck Valley Reservoirs Fish Stocking and Operation and Maintenance, 2005-2006 Annual Progress Report.

    SciTech Connect

    Sellman, Jake; Dykstra, Tim

    2009-05-11

    The Duck Valley Reservoirs Fish Stocking and Operations and Maintenance (DV Fisheries) project is an ongoing resident fish program designed to enhance both subsistence fishing, educational opportunities for Tribal members of the Shoshone-Paiute Tribes, and recreational fishing facilities for non-Tribal members. In addition to stocking rainbow trout (Oncorhynchus mykiss) in Mountain View, Lake Billy Shaw, and Sheep Creek Reservoirs, the program also intends to afford and maintain healthy aquatic conditions for fish growth and survival, to provide superior facilities with wilderness qualities to attract non-Tribal angler use, and to offer clear, consistent communication with the Tribal community about this project as well as outreach and education within the region and the local community. Tasks for this performance period are divided into operations and maintenance plus monitoring and evaluation. Operation and maintenance of the three reservoirs include fences, roads, dams and all reservoir structures, feeder canals, water troughs and stock ponds, educational signs, vehicles and equipment, and outhouses. Monitoring and evaluation activities included creel, gillnet, wildlife, and bird surveys, water quality and reservoir structures monitoring, native vegetation planting, photo point documentation, control of encroaching exotic vegetation, and community outreach and education. The three reservoirs are monitored in terms of water quality and fishery success. Sheep Creek Reservoir was the least productive as a result of high turbidity levels and constraining water quality parameters. Lake Billy Shaw trout were in poorer condition than in previous years potentially as a result of water quality or other factors. Mountain View Reservoir trout exhibit the best health of the three reservoirs and was the only reservoir to receive constant flows of water.

  16. Treatment of G1 Baskets at the CEA Marcoule Site - 12027

    SciTech Connect

    Fourquet, Line; Boya, Didier

    2012-07-01

    In the dismantling program for the first-generation French reactors in accordance with the nonproliferation treaty, the CEA is in charge of cleanup and dismantling operations for the facilities at Marcoule, including the decladding units. The G1 decladding was built between 1955 and 1957 in order to de-clad spent fuel elements from the G1 plutonium-producing reactor and prepare them for dissolution. The facility was also used for interim storage of G1, G2 and G3 fuel dissolution baskets, which had been used during plant operation for transfer (from the decladding facility to the UP1 plant) and/or dissolution of spent fuel elements. One of the cleanup projects involves recovery of the baskets, which will be cut up, sorted, and conditioned in metal bins. The bins will be immobilized with cement grout, then transferred to the onsite solid waste conditioning facility (CDS) and to the repository operated by the French National Radioactive Waste Management Agency (ANDRA). The project is now in progress, after special safety permits were issued and measurement stations and dedicated tools were developed to handle all types of baskets (which differed according to their origin and use). The disposal of all the baskets is scheduled to last 2 years and will produce 55 metal waste bins. (authors)

  17. The 400W at 1.8K Test Facility at CEA-Grenoble

    NASA Astrophysics Data System (ADS)

    Roussel, P.; Girard, A.; Jager, B.; Rousset, B.; Bonnay, P.; Millet, F.; Gully, P.

    2006-04-01

    A new test facility with a cooling capacity respectively of 400W at 1.8K or 800W at 4.5K, is now under nominal operation in SBT (Low Temperature Department) at CEA Grenoble. It has been recently used for thermohydraulic studies of two phase superfluid helium in autumn 2004. In the near future, this test bench will allow: - to test industrial components at 1.8K (magnets, cavities of accelerators) - to continue the present studies on thermohydraulics of two phase superfluid helium - to develop and simulate new cooling loops for ITER Cryogenics, and other applications such as high Reynolds number flows This new facility consists of a cold box connected to a warm compressor station (one subatmospheric oil ring pump in series with two screw compressors). The cold box, designed by AIR LIQUIDE, comprises two centrifugal cold compressors, a cold turbine, a wet piston expander, counter flow heat exchangers and two phase separators at 4.5K and 1.8K. The new facility uses a Programmable Logic Controller (PLC) connected to a bus for the measurements. The design is modular and will allow the use of saturated fluid flow (two phase flow at 1.8K or 4.5K) or single phase fluid forced flow. Experimental results and cooling capacity in different operation modes are detailed.

  18. X-ray detector calibration at CEA/Bruyères-le-Châtel

    NASA Astrophysics Data System (ADS)

    Beck, L.; Stemmler, P.; Ban, G.; Villette, B.; Frotté, V.; Bizeuil, C.; Boutin, J.-Y.; Nazet, C.

    1996-02-01

    At CEA/Bruyères-le-Châtel (Service CEM), there are facilities to calibrate X-ray detectors from 200 eV to 100 keV, with an accuracy of 4% at high energies ( E > 3 keV). The source is the direct radiation from the X-ray tubes [C Kα (277 eV) to Ti KαKβ (4.51/4.93 keV)] or fluorescence emission from secondary targets [Mg Kα (1.25 keV) to U Kα (98 keV)]. In addition, calibrations are carried out with the synchrotron radiation of the Super-ACO storage ring (LURE-Orsay), by selecting the monoenergetic beams with a double crystal monochromator which is tunable between 0.8 and 8 keV. The resolution is better than 1 eV. This last tool is very useful in the study of the absorption edges of the detector compounds (for example, Si K-edge and Ar K-edge). Some examples are presented of results obtained between 1 and 50 keV, with special reference to high flux detectors such as gold photocathodes and silicon avalanche photodiodes. Thick silicon photodiodes (for the high energy range) were also calibrated.

  19. Status of the light ion source developments at CEA/Saclay

    NASA Astrophysics Data System (ADS)

    Gobin, R.; Beauvais, P.-Y.; Bogard, D.; Charruau, G.; Delferrière, O.; De Menezes, D.; France, A.; Ferdinand, R.; Gauthier, Y.; Harrault, F.; Mattéi, P.; Benmeziane, K.; Leherissier, P.; Paquet, J.-Y.; Ausset, P.; Bousson, S.; Gardes, D.; Olivier, A.; Celona, L.; Sherman, J.

    2004-05-01

    SILHI (High Intensity Light Ion Source) is an ECR ion source producing high intensity proton or deuteron beams at 95 keV. It is now installed in the IPHI site building, at the CEA/Saclay center. IPHI is a front end demonstrator of high power accelerator. The source regularly delivers more than 130 mA protons in cw mode and already produced more than 170 mA deuterons in pulsed mode at nominal energy. The last beam characterizations, including emittance measurements, space charge compensation analysis, and diagnostic improvements, will be reported. Taking into account the SILHI experience, new developments are in progress to build and test a 5 mA deuteron source working in cw mode. This new source will also operate at 2.45 GHz and permanent magnets will provide the magnetic configuration. This source, of which the design will be discussed, will have to fit in with the SPIRAL 2 accelerator developed at GANIL to produce radioactive ion beams. The H- test stand status is briefly presented here and detailed in companion papers.

  20. Application of boronated anti-CEA immunoliposome to tumour cell growth inhibition in in vitro boron neutron capture therapy model.

    PubMed Central

    Yanagië, H.; Tomita, T.; Kobayashi, H.; Fujii, Y.; Takahashi, T.; Hasumi, K.; Nariuchi, H.; Sekiguchi, M.

    1991-01-01

    An immunoliposome containing a 10B-compound has been examined as a selective drug delivery system in boron neutron-capture therapy. Liposomes, conjugated with monoclonal antibodies specific for carcinoembryonic antigen (CEA) were shown to bind selectively to cells bearing CEA on their surface. The immunoliposomes attached to tumour cells suppressed growth in vitro upon thermal neutron irradiation and suppression was dependent upon the concentration of the 10B-compound in the liposomes and on the density of antibody conjugated to the liposomes. The results suggest that immunoliposomes containing the 10B-compound could act as a selective and efficient carrier of 10B atoms to target tumour cells in boron neutron-capture therapy. Images Figure 1 PMID:2021537

  1. Enhanced antitumor effect of combining TRAIL and MnSOD mediated by CEA-controlled oncolytic adenovirus in lung cancer.

    PubMed

    Zhang, R; Zhang, X; Ma, B; Xiao, B; Huang, F; Huang, P; Ying, C; Liu, T; Wang, Y

    2016-06-01

    Lung cancer, especially adenocarcinoma, is one of the leading causes of death in the world. Carcinoembryonic antigen (CEA), a superb non-small-cell lung cancer marker candidate, showed a beneficial effect in cancer therapy with oncolytic adenovirus in recent studies. Cancer-targeting dual gene-virotherapy delivers two therapeutic genes, linked by a connexon, in the replication-deficient vector instead of one gene so that they can work in common. In this study, we constructed a tumor-specific oncolytic adenovirus, CD55-TRAIL-IETD-MnSOD. The virus has the fusion protein complementary DNAs for tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) and for manganese superoxide dismutase (MnSOD) complementary DNA linked through a 4-amino acid caspase-8 cleavage site (IETD), and uses a CEA promoter to control virus E1A express. This is the first work to use a CEA promoter-regulated oncolytic adenovirus carrying two therapeutic genes for cancer research. Its targeting and anticancer capacity was evaluated by in vitro and in vivo experiments. The results indicated that CD55-TRAIL-IETD-MnSOD caused more cell apoptosis than CD55-TRAIL or CD55-MnSOD alone, or their combination in vitro, with low cytotoxicity of normal cells. In the A549 tumor xenograft model in nude mice, data showed that CD55-TRAIL-IETD-MnSOD could effectively suppress tumor growth than single gene groups, with no histological damage in liver, spleen or kidney tissues. Thus, the CEA-regulated dual-gene oncolytic virus CD55-TRAIL-IETD-MnSOD may be a novel potential therapy for lung cancer. PMID:27080225

  2. Comparison of CEAS and Williams-type models for spring wheat yields in North Dakota and Minnesota

    NASA Technical Reports Server (NTRS)

    Barnett, T. L. (Principal Investigator)

    1982-01-01

    The CEAS and Williams-type yield models are both based on multiple regression analysis of historical time series data at CRD level. The CEAS model develops a separate relation for each CRD; the Williams-type model pools CRD data to regional level (groups of similar CRDs). Basic variables considered in the analyses are USDA yield, monthly mean temperature, monthly precipitation, and variables derived from these. The Williams-type model also used soil texture and topographic information. Technological trend is represented in both by piecewise linear functions of year. Indicators of yield reliability obtained from a ten-year bootstrap test of each model (1970-1979) demonstrate that the models are very similar in performance in all respects. Both models are about equally objective, adequate, timely, simple, and inexpensive. Both consider scientific knowledge on a broad scale but not in detail. Neither provides a good current measure of modeled yield reliability. The CEAS model is considered very slightly preferable for AgRISTARS applications.

  3. SNS BEAM COMMISSIONING TOOLS AND EXPERIENCE

    SciTech Connect

    Shishlo, Andrei P; Galambos, John D

    2008-01-01

    The Spallation Neutron Source (SNS) successfully met the primary construction project completion milestones in April 2006. An important ingredient of this successful commissioning was the development and use of software tools. With the increasing digitalization of beam diagnostics and increasing complexity of Integrated Control Systems of large accelerators, the need for high level software tools is critical for smooth commissioning. At SNS a special Java based infrastructure called XAL was prepared for beam commissioning. XAL provides a hierarchal view of the accelerator, is data base configured, and includes a physics model of the beam. This infrastructure and individual applications development along with a historical time line of the SNS commissioning will be discussed.

  4. 77 FR 50492 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-21

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  5. 77 FR 73645 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-12-11

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  6. 77 FR 38045 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  7. 77 FR 28869 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-16

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services, Inc.: 2012...

  8. 77 FR 31004 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-24

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  9. 77 FR 47620 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-09

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the PJM Interconnection, LLC (PJM): PJM...

  10. 77 FR 3764 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Midwest Independent Transmission System...

  11. 77 FR 42300 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-18

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  12. 77 FR 64983 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-10-24

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  13. 77 FR 16221 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  14. 76 FR 76157 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-12-06

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  15. 77 FR 58376 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-20

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  16. 77 FR 38046 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-26

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services, Inc.: 2012...

  17. 77 FR 34034 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-08

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Southwest Power Pool, Inc. (SPP):...

  18. 76 FR 60820 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-30

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Midwest Independent Transmission System...

  19. 77 FR 37665 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-06-22

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the North Carolina Transmission Planning...

  20. 77 FR 40606 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-10

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the Midwest Independent Transmission System...

  1. 77 FR 6556 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-02-08

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southwest Power Pool, Inc. (SPP):...

  2. 77 FR 21765 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-11

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southwest Power Pool, Inc. (SPP):...

  3. 78 FR 44165 - Nuclear Regulatory Commission Enforcement Policy

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-07-23

    ... From the Federal Register Online via the Government Publishing Office NUCLEAR REGULATORY COMMISSION Nuclear Regulatory Commission Enforcement Policy AGENCY: Nuclear Regulatory Commission. ACTION: Enforcement policy; request for comment. SUMMARY: The U.S. Nuclear Regulatory Commission (NRC) is...

  4. 77 FR 24485 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-04-24

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission hereby gives notice that members of the Commission's staff may attend the following...

  5. Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients

    PubMed Central

    Wang, Bin; Zhao, Zhiping; Xie, Xiaoming; Wei, Weidong

    2016-01-01

    Previous studies have indicated that carcinoembryonic antigen (CEA) and cancer antigen 15–3 (CA15-3) levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer (TNBC) remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I–IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival (OS) and disease-free survival (DFS) rates than those in the low-level groups (p<0.05). Multivariate analysis suggested that pre-therapeutic CA15-3 and CEA levels are independent predictive elements for OS (p = 0.022 and p = 0.040, respectively) and DFS (p = 0.023 and p = 0.028, respectively). In addition, novel nomograms were established and validated to provide personal forecasts of OS and DFS for patients with TNBC. These novel nomograms may help physicians to select the optimal treatment plans to ensure the best outcomes for TNBC patients. PMID:27561099

  6. Nomograms for Predicting the Prognostic Value of Pre-Therapeutic CA15-3 and CEA Serum Levels in TNBC Patients.

    PubMed

    Dai, Danian; Chen, Bo; Tang, Hailin; Wang, Bin; Zhao, Zhiping; Xie, Xiaoming; Wei, Weidong

    2016-01-01

    Previous studies have indicated that carcinoembryonic antigen (CEA) and cancer antigen 15-3 (CA15-3) levels are both independent prognostic factors in breast cancer. However, the utility of CEA and CA15-3 levels as conventional cancer biomarkers in patients with triple-negative breast cancer (TNBC) remains controversial. The current study was performed to explore the predictive value of pre-therapeutic serum CEA and CA15-3 levels, and nomograms were developed including these serum cancer biomarkers to improve the prognostic evaluation of TNBC patients. Pre-therapeutic CA15-3 and CEA concentrations were measured in 247 patients with stage I-IV TNBC. Kaplan-Meier analysis showed that TNBC patients with high levels of both CEA and CA15-3 had shorter overall survival (OS) and disease-free survival (DFS) rates than those in the low-level groups (p<0.05). Multivariate analysis suggested that pre-therapeutic CA15-3 and CEA levels are independent predictive elements for OS (p = 0.022 and p = 0.040, respectively) and DFS (p = 0.023 and p = 0.028, respectively). In addition, novel nomograms were established and validated to provide personal forecasts of OS and DFS for patients with TNBC. These novel nomograms may help physicians to select the optimal treatment plans to ensure the best outcomes for TNBC patients. PMID:27561099

  7. 18 CFR 35.31 - Commission review.

    Code of Federal Regulations, 2014 CFR

    2014-04-01

    ... the ASC methodology set forth at 18 CFR 301.1. If the ASC is not in accord with the methodology, the... Commission under this subpart is computed in accordance with 18 CFR 35.19a. Interest on any increase ordered... 18 Conservation of Power and Water Resources 1 2014-04-01 2014-04-01 false Commission review....

  8. 17 CFR 201.57 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-04-01

    ... Regulations Pertaining to the Equal Access to Justice Act § 201.57 Commission review. In accordance with the procedures set forth in 17 CFR 201.410 and 201.411, either the applicant or counsel for the Office or... 17 Commodity and Securities Exchanges 2 2010-04-01 2010-04-01 false Commission review....

  9. Appalachian Regional Commission Annual Report, 2001.

    ERIC Educational Resources Information Center

    Appalachian Regional Commission, Washington, DC.

    In fiscal year 2001, the Appalachian Regional Commission invested $63.6 million in 469 economic and human development (nonhighway) projects and $389.6 million in highway projects in Appalachia. The Commission launched a new initiative to promote the development of telecommunications infrastructure, especially in distressed counties. The Commission…

  10. The Civil Rights Commission Must Persist

    ERIC Educational Resources Information Center

    Reynolds, Gerald A.

    2007-01-01

    Columnist George Will and others have questioned the continuing need for a federal civil rights commission, because civil rights protections have been on the books since 1964. The chairman of the Commission, Gerald Reynolds, here responds that practitioners of critical legal theory, advocates of the Akaka-Secession bill, some proponents of…

  11. Federal Trade Commission Semiannual Regulatory Agenda

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-04-26

    ... No. 12866 ``Regulatory Planning and Review'' of September 30, 1993, 58 FR 51735 (Oct. 4, 1993). Since... Final Rule, which the Commission issued jointly with the Federal Reserve on January 15, 2010 (75 FR 2724... Regulatory Plan narrative. 74 FR 64137, 64366. The Commission has also responded to the optional...

  12. 77 FR 67637 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-11-13

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Equity and Excellence Commission AGENCY: U.S. Department of Education, Office for Civil Rights. ACTION... Federal Official, Equity and Excellence Commission, U.S. Department of Education, 400 Maryland Avenue...

  13. 77 FR 484 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-05

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF EDUCATION Equity and Excellence Commission AGENCY: Office for Civil Rights, U.S. Department of Education. ACTION..., Equity and Excellence Commission, U.S. Department of Education, 400 Maryland Avenue SW, Washington,...

  14. Commission on Preservation and Access Newsletter, 1995.

    ERIC Educational Resources Information Center

    Commission on Preservation and Access Newsletter, 1995

    1995-01-01

    The Commission on Preservation and Access was established to foster and support collaboration among libraries and allied organizations in order to ensure the preservation of the published and documentary records in all formats and to provide enhanced access to scholarly information. The Commission's newsletter keeps preservation and access…

  15. Setting up Blue Ribbon Commissions. Issuegram 15.

    ERIC Educational Resources Information Center

    Palaich, Robert; And Others

    Options and suggestions for setting up successful study commissions were gathered from 10 commissions that had recommended revisions of state educational policy on a variety of issues. Composed of respected citizens from across the state, each task force was created by the governor or legislature for a fixed duration. Some recommendations for…

  16. CCRIS: Carnegie Commission Reports Information System.

    ERIC Educational Resources Information Center

    Lavin, Mary Jo

    The Carnegie Commission Reports Information System (CCRIS) attempts to make the findings of the 22 Commission reports (published by McGraw Hill Book Company) more readily available to the academic community. CCRIS consists of an explanatory text of 16 pages introducing the reader to a set of 1500 edge-notched McBee cards. Each card contains a…

  17. 76 FR 53159 - CFC-50 Commission Meeting

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-08-25

    ... MANAGEMENT CFC-50 Commission Meeting AGENCY: Office of Personnel Management. ACTION: Establishment of..., 2011, at the time and location shown below. The Commission shall advise the Director of the U.S. Office of Personnel Management (OPM) on strengthening the integrity, the operation and effectiveness of...

  18. 76 FR 72452 - CFC-50 Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-11-23

    ... MANAGEMENT CFC-50 Commission AGENCY: Office of Personnel Management. ACTION: Establishment of advisory... time and location shown below. The Commission shall advise the Director of the U.S. Office of Personnel Management (OPM) on strengthening the integrity, the operation and effectiveness of the Combined...

  19. Wyoming Community College Commission Annual Report, 2010

    ERIC Educational Resources Information Center

    Wyoming Community College Commission, 2010

    2010-01-01

    The Wyoming Community College Commission (WCCC) serves the system of Wyoming's seven community colleges. Wyoming's seven community colleges provide affordable, accessible and lifelong education. The Wyoming Community College Commission supports the colleges through advocacy, coordination and collaboration. In partnership with the colleges, the…

  20. Commission 25: Stellar Photometry and Polarimetry

    NASA Astrophysics Data System (ADS)

    Martinez, Peter; Milone, Eugene; Landolt, Arlo; Jordi, Carme; Mironov, Aleksey; Shenbang, Qian; Schmidt, Edward; Sterken, Christiaan

    2010-05-01

    The Business Meeting for Commission 25 was held on the 6th of August 2009. The meeting was chaired by Dr Eugene Milone, Vice President for the 2006-2009 triennium, and incoming President for the 2009-2011 triennium. Dr Milone presented an apology from the President of the Commission, Dr Peter Martinez, who was unable to attend the meeting.

  1. Commissioning MMS: Challenges and Lessons Learned

    NASA Technical Reports Server (NTRS)

    Wood, Paul; Gramling, Cheryl; Reiter, Jennifer; Smith, Patrick; Stone, John

    2016-01-01

    This paper discusses commissioning of NASA's Magnetospheric MultiScale (MMS) Mission. The mission includes four identical spacecraft with a large, complex set of instrumentation. The planning for and execution of commissioning for this mission is described. The paper concludes by discussing lessons learned.

  2. Commission 12: Solar Radiation and Structure

    NASA Astrophysics Data System (ADS)

    Cauzzi, Gianna; Shchukina, Nataliya; Kosovichev, Alexander; Bianda, Michele; Brandenburg, Axel; Chou, Dean-Yi; Dasso, Sergio; Ding, Ming-De; Jefferies, Stuart; Krivova, Natalie; Kuznetsov, Vladimir D.; Moreno-Insertis, Fernando

    2016-04-01

    Commission 12 of the International Astronomical Union encompasses investigations of the internal structure and dynamics of the Sun, the quiet solar atmosphere, solar radiation and its variability, and the nature of relatively stable magnetic structures like sunspots, faculae and the magnetic network. The Commission sees participation of over 300 scientists worldwide.

  3. A Practical Guide for Commissioning Existing Buildings

    SciTech Connect

    Haasl, T.

    1999-05-11

    Although this guide focuses on the retrocommissioning process and its advantages, all three types of commissioning--retrocommissioning, commissioning, and recommissioning--play an equally important role in ensuring that buildings perform efficiently and provide comfortable, safe, and productive work environments for owners and occupants. For new construction and retrofit projects, commissioning should be incorporated early, during design, and last throughout the length of the project. For buildings that were never commissioned, the retrocommissioning process can yield a wealth of cost-saving opportunities while enhancing a building's environment. Finally, once a building is commissioned or retrocommissioned, incorporating recommissioning into the organization's O and M program (by periodically reapplying the original diagnostic testing and checklist procedures) helps ensure that cost savings and other benefits gained from the original process persist over time.

  4. A Practical Guide for Commissioning Existing Buildings

    SciTech Connect

    Haasl, T.; Sharp, T.

    1999-04-01

    Although this guide focuses on the retrocommissioning process and its advantages, all three types of commissioning--retrocommissioning, commissioning, and recommissioning--play an equally important role in ensuring that buildings perform efficiently and provide comfortable, safe, and productive work environments for owners and occupants. For new construction and retrofit projects, commissioning should be incorporated early, during design, and last throughout the length of the project. For buildings that were never commissioned, the retrocommissioning process can yield a wealth of cost-saving opportunities while enhancing a building's environment. Finally, once a building is commissioned or retrocommissioned, incorporating recommissioning into the organization's O and M program (by periodically reapplying the original diagnostic testing and checklist procedures) helps ensure that cost savings and other benefits gained from the original process persist over time.

  5. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 33 Navigation and Navigable Waters 3 2013-07-01 2013-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  6. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 33 Navigation and Navigable Waters 3 2014-07-01 2014-07-01 false Mississippi River Commission: Public observation of Commission meetings. 209.50 Section 209.50 Navigation and Navigable Waters CORPS OF ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River Commission: Public observation...

  7. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 33 Navigation and Navigable Waters 3 2010-07-01 2010-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  8. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 33 Navigation and Navigable Waters 3 2011-07-01 2011-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  9. 33 CFR 209.50 - Mississippi River Commission: Public observation of Commission meetings.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 33 Navigation and Navigable Waters 3 2012-07-01 2012-07-01 false Mississippi River Commission... ENGINEERS, DEPARTMENT OF THE ARMY, DEPARTMENT OF DEFENSE ADMINISTRATIVE PROCEDURE § 209.50 Mississippi River... of the Mississippi River Commission and to open all meetings of the Mississippi River Commission...

  10. Major Upgrade of the Reactor Dosimetry Interpretation Methodology Used at the CEA General Principle

    NASA Astrophysics Data System (ADS)

    Destouches, C.; Gregoire, G.; Beretz, D.; Bourganel, S.; Chiron, M.

    2009-08-01

    One of the main objectives of reactor dosimetry is the determination of the physical parameters characterizing the neutron field in which test samples are irradiated. These characteristics, from neutron spectrum to reaction rates characterization are used in experimental reactors to carry out the follow-up of the irradiation and to qualify the neutron calculation used to model the experiment. In power reactors these characteristics are used for the follow-up of the predicted damages to vessel and interns. Neutron parameters are derived from the dosimeter's activities which have suitable reactions (response functions and radioactive emissions). Then, the activities are analyzed using nuclear data, neutron computation results and data characterizing the conditions of irradiation (temporal and technological data, changes of location, etc.). The current CEA interpretation process applied for industrial power reactor interpretation process presents limitations coming mainly from the calculational tools and the nuclear data knowledge available at the time this method was developed in the mid 90's. However nowadays due to, first the improvement of the neutron calculational tools, for example, a full 3D Monte Carlo reactor modeling providing reaction in a point wise format is now possible in a reasonable time, and second, recent releases of the updated international nuclear data libraries, JEFF3.1, ENDF/B-VII for transport calculation and IRDF2002 and EAF2007 for dosimetry libraries, we have been engaged in a deep renewal of the reactor dosimetry interpretation process. The mains goals of this works are to improve the modeling of the experiment and the neutron parameters calculation for each phase of interest. In addition, uncertainties associated to the derived metrics are quantified in a rigorous way using simulation methods designed to cope with the high non-linearity of the process. After a detailed presentation of the current interpretation process and its limitations

  11. Phase I Hepatic Immunotherapy for Metastases study of intra-arterial chimeric antigen receptor modified T cell therapy for CEA+ liver metastases

    PubMed Central

    Katz, Steven C.; Burga, Rachel A.; McCormack, Elise; Wang, Li Juan; Mooring, Wesley; Point, Gary; Khare, Pranay D.; Thorn, Mitchell; Ma, Qiangzhong; Stainken, Brian F.; Assanah, Earle O.; Davies, Robin; Espat, N. Joseph; Junghans, Richard P.

    2015-01-01

    Purpose Chimeric antigen receptor modified T cells (CAR-T) have demonstrated encouraging results in early-phase clinical trials. Successful adaptation of CAR-T technology for CEA-expressing adenocarcinoma liver metastases (LM), a major cause of death in patients with gastrointestinal cancers, has yet to be achieved. We sought to test intrahepatic delivery of anti-CEA CAR-T through percutaneous hepatic artery infusions (HAI). Experimental Design We conducted a phase I trial to test HAI of CAR-T in patients with CEA+ LM. Six patients completed the protocol, and 3 received anti-CEA CAR-T HAIs alone in dose-escalation fashion (108, 109, and 1010 cells). We treated an additional 3 patients with the maximum planned CAR-T HAI dose (1010 cells X 3) along with systemic IL2 support. Results Four patients had more than 10 LM and patients received a mean of 2.5 lines of conventional systemic therapy prior to enrollment. No patient suffered a grade 3 or 4 adverse event related to the CAR-T HAIs. One patient remains alive with stable disease at 23 months following CAR-T HAI and 5 patients died of progressive disease. Among the patients in the cohort that received systemic IL2 support, CEA levels decreased 37% (range 19–48%) from baseline. Biopsies demonstrated an increase in LM necrosis or fibrosis in 4 of 6 patients. Elevated serum IFNγ levels correlated with IL2 administration and CEA decreases. Conclusions We have demonstrated the safety of anti-CEA CAR-T HAIs with encouraging signals of clinical activity in a heavily pre-treated population with large tumor burdens. Further clinical testing of CAR-T HAIs for LM is warranted. PMID:25850950

  12. Evaluation of serum CEA, CYFRA21-1 and CA125 for the early detection of colorectal cancer using longitudinal preclinical samples

    PubMed Central

    Thomas, D S; Fourkala, E-O; Apostolidou, S; Gunu, R; Ryan, A; Jacobs, I; Menon, U; Alderton, W; Gentry-Maharaj, A; Timms, J F

    2015-01-01

    Background: Blood-borne biomarkers for early detection of colorectal cancer (CRC) could markedly increase screening uptake. The aim of this study was to evaluate serum carcinoembryonic antigen (CEA), CYFRA21-1 and CA125 for the early detection of CRC in an asymptomatic cohort. Methods: This nested case–control study within UKCTOCS used 381 serial serum samples from 40 women subsequently diagnosed with CRC, 20 women subsequently diagnosed with benign disease and 40 matched non-cancer controls with three to four samples per subject taken annually up to 4 years before diagnosis. CEA, CYFRA21-1 and CA125 were measured using validated assays and performance of markers evaluated for different pre-diagnosis time groups. Results: CEA levels increased towards diagnosis in a third of all cases (half of late-stage cases), whereas longitudinal profiles were static in both benign and non-cancer controls. At a threshold of >5 ng ml−1 the sensitivities for detecting CRC up to 1 and 4 years before clinical presentation were 25% and 13%, respectively, at 95% specificity. At a threshold of >2.5 ng ml−1, sensitivities were 57.5% and 38.4%, respectively, with specificities of 81% and 83.5%. CYFRA21-1 and CA125 had no utility as screening markers and did not enhance CEA performance when used in combination. CEA gave average lead times of 17–24 months for test-positive cases. Conclusions: CEA is elevated in a significant proportion of individuals with preclinical CRC, but would not be useful alone as a screening tool. This work sets a baseline from which to develop panels of biomarkers which combine CEA for improved early detection of CRC. PMID:26035703

  13. Automated Commissioning for Lower-cost, Widely Deployed Building Commissioning of the Future

    SciTech Connect

    Brambley, Michael R.; Katipamula, Srinivas

    2011-08-16

    This chapter takes a brief look at the benefits of commissioning and describes a vision of the future where most of the objectives of commissioning will be accomplished automatically by capabilities built into the building systems themselves. Commissioning will become an activity that is performed continuously rather than periodically, and only repairs requiring replacement or overhaul of equipment will require manual intervention. This chapter then identifies some of the technologies that will be needed to realize this vision and ends with a call for all involved in the enterprise of building commissioning and automation to embrace and dedicate themselves to a future of automated commissioning.

  14. Instrumented home energy rating and commissioning

    SciTech Connect

    Wray, Craig P.; Walker, Iain S.; Sherman, Max H.

    2003-05-01

    Currently, houses do not perform optimally or even as many codes and forecasts predict, largely because they are field assembled and there is no consistent process to identify deficiencies or to correct them. Solving this problem requires field performance evaluations using appropriate and agreed upon procedures in the form of a new process called residential commissioning. The purpose of this project is to develop and document these procedures and to demonstrate the value that applying them could provide in both new and existing California houses. This project has four specific objectives: to develop metrics and diagnostics for assessing house performance, to provide information on the potential benefits of commissioning using a whole-house approach, to develop programmatic guidelines for commissioning, and to conduct outreach efforts to transfer project results to industry stakeholders. The primary outcomes from this project are the development of residential commissioning guidelines and the analytical confirmation that there are significant potential benefits associated with commissioning California houses, particularly existing ones. In addition, we have made substantial advances in understanding the accuracy and usability of diagnostics for commissioning houses. In some cases, we have been able to work with equipment manufacturers to improve these aspects of their diagnostic tools. These outcomes provide a solid foundation on which to build a residential commissioning program in California. We expect that a concerted effort will be necessary to integrate such a program with existing building industry efforts and to demonstrate its use in the field.

  15. The Pepper Commission Report and the response.

    PubMed

    1990-01-01

    The recommendations of the "Pepper Commission" [the Bipartisan Commission on Comprehensive Health Care] on health care policy reform (see box on page 20) would cost an estimated $66 billion to implement. As a result, many in Congress already have declared the Pepper report to be politically nonviable. Nevertheless, Commission Chairman John D. Rockefeller IV intends to pursue legislative activity on the report. Recently, Rockefeller said that the Commission's majority recommendations likely will be offered in Congress as one large bill--with the option to break out some of its features for individual consideration. For example, Rockefeller said he will try this year to enact the Commission's recommendations to improve health care coverage for pregnant women and children--as well as suggestions for reform in the health insurance industry. The West Virginia senator said he believes these two proposals will cost about $3.5 billion in new federal funds. The basics of the plan, and the political obstacles facing its enactment, were discussed by several members of the Pepper Commission during the press conference at which the recommendations were unveiled. FAHS Review covered that press conference, and below we reprint excerpts from a tape transcription of the remarks of several Commission members. PMID:10113210

  16. Research at the CEA in the field of safety in 2nd and 3rd generation light water reactors

    NASA Astrophysics Data System (ADS)

    Billot, Philippe

    2012-05-01

    The research programs at the CEA in the field of safety in nuclear reactors are carried out in a framework of international partnerships. Their purpose is to develop studies on: The methods allowing for the determination of earthquake hazards and their consequences; The behaviour of fuel in an accident situation; The comprehension of deflagration and detonation phenomena of hydrogen and the search for effective prevention methods involving an explosion risk; The cooling of corium in order to stop its progression in and outside the vessel thereby reducing the risk of perforating the basemat; The behaviour of the different fission product families according to their volatility for the UO2 and MOX fuels.

  17. Nuclear data uncertainty propagation for neutronic key parameters of CEA's SFR V2B and CFV sodium fast reactor designs

    SciTech Connect

    Archier, P.; Buiron, L.; De Saint Jean, C.; Dos Santos, N.

    2012-07-01

    This paper presents a nuclear data uncertainty propagation analysis for two CEA's Sodium-cooled Fast Reactor designs: the SFR V2B and CFV cores. The nuclear data covariance matrices are provided by the DER/SPRC/LEPh's nuclear data team (see companion paper) for several major isotopes. From the current status of this analysis, improvements on certain nuclear data reactions are highlighted as well as the need for new specific integral experiments in order to meet the technological breakthroughs proposed by the CFV core. (authors)

  18. Sandia National Laboratories results for the 2010 criticality accident dosimetry exercise, at the CALIBAN reactor, CEA Valduc France.

    SciTech Connect

    Ward, Dann C.

    2011-09-01

    This document describes the personal nuclear accident dosimeter (PNAD) used by Sandia National Laboratories (SNL) and presents PNAD dosimetry results obtained during the Nuclear Accident Dosimeter Intercomparison Study held 20-23 September, 2010, at CEA Valduc, France. SNL PNADs were exposed in two separate irradiations from the CALIBAN reactor. Biases for reported neutron doses ranged from -15% to +0.4% with an average bias of -7.7%. PNADs were also exposed on the back side of phantoms to assess orientation effects.

  19. Division G Commission 42: Close Binary Stars

    NASA Astrophysics Data System (ADS)

    Richards, Mercedes T.; Pribulla, Theodor; Ribas, Ignasi; Bradstreet, David H.; Dreschsel, Horst; Maceroni, Carla; Mikolajewska, Joanna; Munari, Ulisse; Prsa, Andrej; Scharfe, Colin; Southworth, John; Trimble, Virginia

    2016-04-01

    Commission 42 began life as Photometric Double Stars in 1948 at the 7th General Assembly in Zurich, under the presidency of Zdenek Kopal. As early as 1961, then General Secretary Lukas Plaut recommended a merger between C42 and C26, Double Stars, one of the original 32 commissions going back to 1919-22 (first president Aitken, assistant director at Lick). C42 became Close Binary Stars in 1970, at the 14th GA in Brighton (the first one I attended). Table 1 shows the presidents of C42, and vice presidents, from when the office started, through the history of the Commission.

  20. 76 FR 6774 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-08

    ... finance systems to achieve equity in the distribution of educational resources and further ] student performance, especially for the students at the lower end of the achievement gap. The Commission will...

  1. 76 FR 55059 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-09-06

    ... finance systems to achieve equity in the distribution of educational resources and further student performance, especially for the students at the lower end of the achievement gap. The Commission will...

  2. 77 FR 49441 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-16

    ... finance systems to achieve equity in the distribution of educational resources and further student performance, especially for the students at the lower end of the achievement gap. The Commission will...

  3. 10 CFR 110.40 - Commission review.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... Canada. (5) An export involving assistance to end uses related to isotope separation, chemical... up to 5 percent in the isotope uranium-235, and those categories of exports which the Commission...

  4. Commissioning medical education: principles for best practice.

    PubMed

    Walsh, Kieran

    2016-04-01

    We need to ensure that we get value for money for our investments in medical education. Commissioning is one method of ensuring that we get value. However, like any other tool, it needs to be used properly. PMID:27071431

  5. Presidential commission investigating Challenger accident at JSC

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Views of the Presidential commission investigating the Challenger accident at Johnson Space Center (JSC). Two JSC Officials chat prior to a meeting with members of the Presidential Commission on the Space Shuttle Challenger accident, while one of the commissioners studies his notes. Left to right in the foreground are Richard H. Kohrs, Deputy Manager of the National Space Transportation System (NSTS) program office; JSC Deputy Director Robert C. Goetz and Joseph F. Sutter (28749); Two JSC Officials and two members of the Commission meet in the Executive Conference Room of JSC's Project Management Building. Left to right are Goetz; Kohrs; Sutter and Dr. Arthur B.C. Walker Jr. (28750); More meeting between NASA and the commission. Left to right are Goetz; Kohrs; Walker and Robert W. Rummel and Joseph F. Sutter (28751).

  6. 75 FR 48662 - Equity and Excellence Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-08-11

    ... Secretary for Civil Rights. Nomination Process: Any interested person or organization may nominate one or...: Send to: WhiteHouseLiaison@ed.gov (specify in the e-mail subject line, ``Equity Commission...

  7. 16 CFR 1101.51 - Commission interpretation.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... INFORMATION DISCLOSURE UNDER SECTION 6(b) OF THE CONSUMER PRODUCT SAFETY ACT Retraction § 1101.51 Commission... retraction of such inaccurate or misleading information. (b) Scope. Section 6(b)(7) applies to inaccurate...

  8. Division II: Commission 10: Solar Activity

    NASA Astrophysics Data System (ADS)

    van Driel-Gesztelyi, Lidia; Scrijver, Karel J.; Klimchuk, James A.; Charbonneau, Paul; Fletcher, Lyndsay; Hasan, S. Sirajul; Hudson, Hugh S.; Kusano, Kanya; Mandrini, Cristina H.; Peter, Hardi; Vršnak, Bojan; Yan, Yihua

    2015-08-01

    The Business Meeting of Commission 10 was held as part of the Business Meeting of Division II (Sun and Heliosphere), chaired by Valentin Martínez-Pillet, the President of the Division. The President of Commission 10 (C10; Solar activity), Lidia van Driel-Gesztelyi, took the chair for the business meeting of C10. She summarised the activities of C10 over the triennium and the election of the incoming OC.

  9. Division B Commission 40: Radio Astronomy

    NASA Astrophysics Data System (ADS)

    Chapman, Jessica M.; Giovaninni, Gabriele; Taylor, Russell; Carilli, Christopher; Hills, Richard; Hirabayashi, Hisashi; Jonas, Justin L.; Lazio, Joseph; Morganti, Rafaella; Nan, Rendong; Rubio, Monica; Shastri, Prjaval; Kellermann, Ken; Ekers, Ronald; Ohishi, Masatoshi

    2016-04-01

    IAU Commission 40 for Radio Astronomy (hereafter C40) brought together scientists and engineers who carry out observational and theoretical research in radio astronomy and who develop and operate the ground and space-based radio astronomy facilities and instrumentation. As of June 2015, the Commission had approximately 1,100 members from 49 countries, corresponding to nearly 10 per cent of the total IAU membership.

  10. 47 CFR 0.416 - The Federal Communications Commission Record.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 1 2010-10-01 2010-10-01 false The Federal Communications Commission Record. 0.416 Section 0.416 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION General Information Printed Publications § 0.416 The Federal Communications Commission Record. Texts adopted by the Commission or a member of...

  11. 78 FR 26361 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-05-06

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of ISO New England Inc., New York...

  12. 77 FR 30003 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-05-21

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southwest Power Pool, Inc. (SPP):...

  13. 77 FR 3765 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-01-25

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of the New York Independent System Operator,...

  14. 78 FR 14783 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-03-07

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meetings related to the transmission planning activities of ISO New England Inc., New York...

  15. 77 FR 42717 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-07-20

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the PJM Interconnection, L.L.C....

  16. 77 FR 16221 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-03-20

    ... Federal Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southwest Power Pool, Inc. (SPP):...

  17. 78 FR 37214 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-06-20

    ... Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy Regulatory Commission (Commission) hereby gives notice that members of the Commission's staff may attend the following meeting related to the transmission planning activities of the Southern Company Services, Inc. and...

  18. 46 CFR 502.24 - Practice before the Commission defined.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 9 2014-10-01 2014-10-01 false Practice before the Commission defined. 502.24 Section 502.24 Shipping FEDERAL MARITIME COMMISSION GENERAL AND ADMINISTRATIVE PROVISIONS RULES OF PRACTICE AND PROCEDURE Appearance and Practice Before the Commission § 502.24 Practice before the Commission defined. (a) Practice before the Commission...

  19. 47 CFR 0.416 - The Federal Communications Commission Record.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 47 Telecommunication 1 2012-10-01 2012-10-01 false The Federal Communications Commission Record. 0.416 Section 0.416 Telecommunication FEDERAL COMMUNICATIONS COMMISSION GENERAL COMMISSION ORGANIZATION General Information Printed Publications § 0.416 The Federal Communications Commission Record. Texts adopted by the Commission or a member of...

  20. Building commissioning: The key to quality assurance

    SciTech Connect

    1998-05-01

    This Guide is written to aid building owners and retrofit project managers currently participating in the Rebuild America program. The Guide provides information on implementing building commissioning projects that will optimize the results of existing building equipment improvements and retrofits projects. It should be used in coordination with Rebuild America`s Community Partnership Handbook. The Handbook describes, in detail, eight important steps necessary for planning and carrying out a community-wide energy-efficiency program. In step number 7 of the Handbook, commissioning is shown to be an integral aspect of implementing a building retrofit. The commissioning process ensures that a facility is safe, efficient, comfortable, and conducive to the presumed activities for which it was constructed. Rebuild America strongly encourages its partners to incorporate commissioning into their retrofit projects. By verifying the correct installation, functioning, operation, and maintenance of equipment, the commissioning process ensures that efficiency measures will continue to deliver benefits over the long term. Although commissioning can take place after the equipment has been installed, it is more effective when it takes place over the entire equipment installation process.

  1. Neutron Activation and Thermoluminescent Detector Responses to a Bare Pulse of the CEA Valduc SILENE Critical Assembly

    SciTech Connect

    Miller, Thomas Martin; Celik, Cihangir; McMahan, Kimberly L.; Lee, Yi-kang; Gagnier, Emmanuel; Authier, Nicolas; Piot, Jerome; Jacquet, Xavier; Rousseau, Guillaume; Reynolds, Kevin H.

    2015-09-01

    This benchmark experiment was conducted as a joint venture between the US Department of Energy (DOE) and the French Commissariat à l'Energie Atomique (CEA). Staff at the Oak Ridge National Laboratory (ORNL) in the US and the Centre de Valduc in France planned this experiment. The experiment was conducted on October 11, 2010 in the SILENE critical assembly facility at Valduc. Several other organizations contributed to this experiment and the subsequent evaluation, including CEA Saclay, Lawrence Livermore National Laboratory (LLNL), the Y-12 National Security Complex (NSC), Babcock International Group in the United Kingdom, and Los Alamos National Laboratory (LANL). The goal of this experiment was to measure neutron activation and thermoluminescent dosimeter (TLD) doses from a source similar to a fissile solution critical excursion. The resulting benchmark can be used for validation of computer codes and nuclear data libraries as required when performing analysis of criticality accident alarm systems (CAASs). A secondary goal of this experiment was to qualitatively test performance of two CAAS detectors similar to those currently and formerly in use in some US DOE facilities. The detectors tested were the CIDAS MkX and the Rocky Flats NCD-91. These detectors were being evaluated to determine whether they would alarm, so they were not expected to generate benchmark quality data.

  2. Diagnostic value of CYFRA 21-1 and CEA for predicting lymph node metastasis in operable lung cancer.

    PubMed

    Chen, Feng; Yan, Cui-E; Li, Jia; Han, Xiao-Hong; Wang, Hai; Qi, Jun

    2015-01-01

    Tumour markers are used extensively for the management of lung cancer, including diagnosis, evaluating effectiveness of treatments, monitoring recurrence after therapy and for predicting prognosis. However, there exists a knowledge gap regarding potential quantitative correlations between tumour marker levels and the extents of lymph node involvement in primary lung cancer. The current study is comprised of 139 lung cancer patients scheduled to undergo surgical operation. Of the 139 patients, 107 were subsequently diagnosed with lung cancer without lymph node involvement and 32 were diagnosed with malignant disease with lymph node involvement by histological examination. Preoperative tumour marker levels were quantified in each patient. The median tumour marker levels were statistically higher in lung cancer patients with malignant lymph nodes than in those who suffered either benign lung disease or carcinoma in situ (Kruskal-Wallistest; P = 0.001). Tumour marker levels were significantly correlated with clinical stage (ANOVA; P = 0.009). When examined as a dichotomous variable (CYFRA 21-1 ≤ 5.0 and CEA ≤ 5.0 group and CYFRA 21-1 > 5.0 or CEA > 5.0 group), elevated tumour marker levels correlated strongly with the presence of positive lymph nodes (χ(2) test; P = 0.000). This correlation suggests that the tumour marker levels are clinical predictors for the malignant involvement of lymph nodes in operable lung cancer patients. PMID:26309663

  3. Ultrasensitive sandwich-type electrochemical immunosensor based on trimetallic nanocomposite signal amplification strategy for the ultrasensitive detection of CEA.

    PubMed

    Tian, Lihui; Liu, Li; Li, Yueyuan; Wei, Qin; Cao, Wei

    2016-01-01

    A novel and ultrasensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of carcino-embryonic antigen (CEA). This immunosensor was developed by using the trimetallic NiAuPt nanoparticles on graphene nanosheets (NGs) nanosheets (NiAuPt-NGs) as excellent labels and β-cyclodextrin functionalized reduced graphene oxide nanosheets (CD-NGs) as the platform. The CD-NGs with high specific surface area good biocompatibility and the ideal dispersibility was used to capture the primary antibodies (Ab1) efficiently. The trimetallic NiAuPt-NGs nanocomposites were used as the labels for signal amplification, showing better electrocatalytic activity towards the reduction of hydrogen peroxide (H2O2), which is much better than that the monometallic Pt-NGs, bimetallic NiPt-NGs and AuPt-NGs due to the synergetic effect presented in NiAuPt-NGs. The NiAuPt-NGs nanocomposites consist of tightly coupled nanostructures of Au, Ni and Pt, which have neither an alloy nor a core-shell structure. Under the optimal conditions, a linear range from 0.001-100 ng/mL and a low detection limit of 0.27 pg/mL were obtained for CEA. The proposed electrochemical sandwich-type immunosensor may have a promising application in bioassay and it enriches the electrochemical immunoassays. PMID:27488806

  4. Ultrasensitive sandwich-type electrochemical immunosensor based on trimetallic nanocomposite signal amplification strategy for the ultrasensitive detection of CEA

    PubMed Central

    Tian, Lihui; Liu, Li; Li, Yueyuan; Wei, Qin; Cao, Wei

    2016-01-01

    A novel and ultrasensitive sandwich-type electrochemical immunosensor was designed for the quantitative detection of carcino-embryonic antigen (CEA). This immunosensor was developed by using the trimetallic NiAuPt nanoparticles on graphene nanosheets (NGs) nanosheets (NiAuPt-NGs) as excellent labels and β-cyclodextrin functionalized reduced graphene oxide nanosheets (CD-NGs) as the platform. The CD-NGs with high specific surface area good biocompatibility and the ideal dispersibility was used to capture the primary antibodies (Ab1) efficiently. The trimetallic NiAuPt-NGs nanocomposites were used as the labels for signal amplification, showing better electrocatalytic activity towards the reduction of hydrogen peroxide (H2O2), which is much better than that the monometallic Pt-NGs, bimetallic NiPt-NGs and AuPt-NGs due to the synergetic effect presented in NiAuPt-NGs. The NiAuPt-NGs nanocomposites consist of tightly coupled nanostructures of Au, Ni and Pt, which have neither an alloy nor a core-shell structure. Under the optimal conditions, a linear range from 0.001–100 ng/mL and a low detection limit of 0.27 pg/mL were obtained for CEA. The proposed electrochemical sandwich-type immunosensor may have a promising application in bioassay and it enriches the electrochemical immunoassays. PMID:27488806

  5. Audit of the Federal Energy Regulatory Commission`s Office of Chief Accountant

    SciTech Connect

    1995-04-07

    The Federal Energy Regulatory Commission`s (Commission) mission is to oversee America`s natural gas and oil pipeline transportation, electric utility, and hydroelectric power industries to ensure that consumers receive adequate energy supplies at just and reasonable rates. To carry out this mission, the Commission issues regulations covering the accounting, reporting, and rate-making requirements of the regulated utility companies. The Commission`s Office of Chief Accountant performs financial related audits at companies to ensure compliance with these regulations. The purpose of this audit was to evaluate the office of Chief Accountant`s audit performance. Specifically, the objectives were to determine if the most appropriate audit approach was used and if a quality assurance process was in place to ensure reports were accurate and supported by the working papers.

  6. Exposure of Enchytraeus albidus to Cd and Zn - changes in cellular energy allocation (CEA) and linkage to transcriptional, enzymatic and reproductive effects.

    PubMed

    Novais, Sara C; Soares, Amadeu M V M; De Coen, Wim; Amorim, Mónica J B

    2013-01-01

    Cellular energy allocation (CEA) is a measure of the energy status of an organism. The effects of Cd and Zn (reproduction EC(50)s and EC(90)s) on the total energy budget of Enchytraeus albidus (Oligochaeta) were assessed through CEA determination, over periods of time from 0 to 8 d. Results showed reduction on the energy reserves for both metals after 2 d exposure. Lipids were the first reserves to be used and carbohydrates were reduced exclusively after Cd exposure. Electron transport system (ETS) activities were enhanced, suggesting increased metabolism and higher energy requirements for metal detoxification. This was supported by previous results at transcription level, where an up-regulation of genes involved in the mitochondrial oxidative phosphorylation was verified. Additionally, the reduction of CEA may be related with the decrease on the reproductive output. These results showed the relevance of integrating various endpoints, which enabled an overview of various processes and to unravel mechanisms of action of chemicals. PMID:23062832

  7. Developments and fabrication of laser targets used to prepare inertial confinement fusion (ICF) experiments on CEA Laser ``M'egajoule'' (LMJ) facility

    NASA Astrophysics Data System (ADS)

    Bednarczyk, Sophie; Durut, Frédéric; Reneaume, Benoît; Théobald, Marc; Casner, Alexis; Tassin, Véronique; Monteil, Marie-Christine; Galmich, Didier

    2008-11-01

    A micro materials and technologies research program has started in France since 10 years to develop a very complex cryogenic target to reach the combustion of a deuterium tritium mixture, by indirect drive on the CEA Laser ``M'egajoule'' (LMJ) facility. This mixture is contained by an amorphous hydrogenated carbon (a-C:H or CHx) doped with germanium capsule placed in the center of a hohlraum. This research program involves CEA scientists, engineers and technicians united to realize specific targets for carrying out laser plasma experiments on the CEA LIL ``Ligne d'Int'egration Laser'' or OMEGA-UPGRADE facilities. To achieve the production of such specific targets different technologies are successively used (coating, precision machining, laser machining, characterizations, assembling, etc). This article presents an illustration of these microtechnology realizations through particular complex laser targets for hydrodynamic, or parametric instabilities studies and for symmetry experimental effects studies on fusion burn.

  8. 76 FR 7839 - Notice of Commission and Commission Staff Attendance at ISO/RTO Council and Regional State...

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-02-11

    ... Energy Regulatory Commission Notice of Commission and Commission Staff Attendance at ISO/RTO Council and... of the Commission and Commission staff may attend the following ISO/RTO Council and Regional State..., RTO/ISO Performance Metrics. For more information, contact Sandra Waldstein, Office of...

  9. 77 FR 47050 - Commission Information Collection Activities; Comment Request

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-07

    ... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Commission Information Collection Activities; Comment Request AGENCY: Federal Energy Regulatory Commission, DOE. ACTION: Comment request. SUMMARY: In compliance with...

  10. 77 FR 52020 - Notice of Commission Staff Attendance

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-08-28

    ... information, contact Jesse Hensley, Office of Energy Market Regulation, Federal Energy Regulatory Commission... From the Federal Register Online via the Government Publishing Office DEPARTMENT OF ENERGY Federal Energy Regulatory Commission Notice of Commission Staff Attendance The Federal Energy...

  11. Combined detection of preoperative serum CEA, CA19-9 and CA242 improve prognostic prediction of surgically treated colorectal cancer patients

    PubMed Central

    Wang, Jingtao; Wang, Xiao; Yu, Fudong; Chen, Jian; Zhao, Senlin; Zhang, Dongyuan; Yu, Yang; Liu, Xisheng; Tang, Huamei; Peng, Zhihai

    2015-01-01

    We assessed the prognostic significance of preoperative serum carcinoembryonic antigen (CEA), carbohydrate antigen 19-9 (CA19-9) and carbohydrate antigen 242 (CA242) levels in surgically treated colorectal cancer patients. The relationship of preoperative serum CEA, CA19-9 and CA242 levels with disease characteristics was investigated in 310 patients. Correlation between tumor markers was investigated using Pearson correlation test. Univariate and multivariate survival analyses were used to study the relationship between preoperative tumor markers and prognosis [disease free survival (DFS) and overall survival (OS)]. Kaplan-Meier analysis with log rank test was used to assess the impact of tumor marker levels on survival. Positive rate of preoperative serum CEA, CA19-9 and CA242 were 54.84%, 47.42% and 37.10%, respectively. High preoperative CEA level was associated with tumor size (P = 0.038), T stage (P < 0.001) and AJCC stage (P = 0.002). High preoperative CA19-9 level was associated with tumor AJCC stage (P = 0.023). Preoperative CA242 positively correlated with CEA (P < 0.001) and CA19-9 (P < 0.001). Combining the three markers was of independent prognostic value in CRC (HR = 2.532, 95% CI: 1.400-4.579, P = 0.002 for OS; and HR = 2.366, 95% CI: 1.334-4.196, P = 0.003 for DFS). Combined detection of preoperative serum CEA, CA19-9 and CA242 is of independent prognostic value for management of CRC patients treated surgically. PMID:26823815

  12. Liver myeloid-derived suppressor cells expand in response to liver metastases in mice and inhibit the anti-tumor efficacy of anti-CEA CAR-T

    PubMed Central

    Burga, Rachel A.; Thorn, Mitchell; Point, Gary R.; Guha, Prajna; Nguyen, Cang T.; Licata, Lauren A.; DeMatteo, Ronald P.; Ayala, Alfred; Espat, N. Joseph; Junghans, Richard P.; Katz, Steven C.

    2015-01-01

    Chimeric antigen receptor modified T cell (CAR-T) technology, a promising immunotherapeutic tool, has not been applied specifically to treat liver metastases (LM). While CAR-T delivery to LM can be optimized by regional intrahepatic infusion, we propose that liver CD11b+Gr-1+ myeloid-derived suppressor cells (L-MDSC) will inhibit the efficacy of CAR-T in the intrahepatic space. We studied anti-CEA CAR-T in a murine model of CEA+ LM and identified mechanisms through which L-MDSC expand and inhibit CAR-T function. We established CEA+ LM in mice and studied purified L-MDSC and responses to treatment with intrahepatic anti-CEA CAR-T infusions. L-MDSC expanded three-fold in response to LM and their expansion was dependent on GM-CSF, which was produced by tumor cells. L-MDSC utilized PD-L1 to suppress anti-tumor responses through engagement of PD-1 on CAR-T. GM-CSF, in cooperation with STAT3, promoted L-MDSC PD-L1 expression. CAR-T efficacy was rescued when mice received CAR-T in combination with MDSC depletion, GM-CSF neutralization to prevent MDSC expansion, or PD-L1 blockade. As L-MDSC suppressed anti-CEA CAR-T, infusion of anti-CEA CAR-T in tandem with agents targeting L-MDSC is a rational strategy for future clinical trials. PMID:25850344

  13. Diagnostic performance of CD66c in lung adenocarcinoma-associated malignant pleural effusion: comparison with CEA, CA 19-9, and CYFRA 21-1.

    PubMed

    Son, Seung-Myoung; Han, Hye-Suk; An, Jin Young; Choe, Kang Hyeon; Lee, Ki Man; Lee, Ki Hyeong; Kim, So-Seul; Lee, Yong-Moon; Lee, Ho-Chang; Song, Hyung Geun; Lee, Ok-Jun

    2015-02-01

    Various tumour markers have been evaluated in malignant pleural effusions, but not CD66c. This study evaluated the diagnostic ability of CD66c in lung adenocarcinoma-associated malignant pleural effusions (LA-MPEs) and compared it with other known tumour markers. Forty-seven cases of LA-MPE and 52 cases of benign pleural effusions were collected. The levels of CD66c, CEA, CA 19-9, and CYFRA 21-1 were measured by enzyme immunoassay. The expression of CD66c, CEA, and CA 19-9 in cell blocks was measured by immunocytochemistry. CEA had the best diagnostic values, with a sensitivity of 87.2% and specificity of 92.3%. Both CD66c and CA 19-9 showed the highest specificity of 98.1%, with sensitivities of 63.8% and 55.3%, respectively. CYFRA 21-1 had a sensitivity of 83.0% and specificity of 76.9%. CEA combined with CA 19-9 reached a sensitivity of 91.5% and a specificity of 98.1%. The sensitivities of immunocytochemical staining for CD66c, CEA, and CA 19-9 were 72.5%, 75%, and 40%, respectively. CD66c showed a diagnostic performance comparable to CYFRA 21-1 and CA 19-9 by enzyme immunoassay. Immunocytochemical study showed that CD66c and CEA were more sensitive than CA19-9. Both studies support CD66c as a potential tumour marker to differentiate LA-MPE from benign effusions. PMID:25551300

  14. Association of serum levels of CEA, CA199, CA125, CYFRA21-1 and CA72-4 and disease characteristics in colorectal cancer.

    PubMed

    Zhong, Wa; Yu, Zhong; Zhan, Jun; Yu, Tao; Lin, Ying; Xia, Zhong-Sheng; Yuan, Yu-Hong; Chen, Qi-Kui

    2015-01-01

    Identifying predictive biomarkers for colorectal cancer would facilitate diagnosis and treatment of the disease. This study aimed to investigate the association of the serological biomarkers CEA, CA19-9, CA125, CYFRA21-1 and CA72-4 with patient characteristics and disease outcomes in colorectal cancer. Patients (N = 373) with colorectal cancer were evaluated for the association of CEA, CA19-9, CA125, CYFRA21-1, and CA72-4 pre and post-surgery and at disease recurrence with demographics, disease characteristics including pathological types, degree of differentiation, invasion depth, abdominal lymph node metastasis, TMN stage, Dukes stage, location of cancer and metastasis, and disease outcomes. It was more common for a patient to express these markers prior to surgery and at disease recurrence than following surgery. Overall, the serum levels of CEA, CA19-9, CA125, CYFRA21-1, and CA72-4 were not associated with age, gender, pathological type and location of cancer (all P-values >0.05), but were associated with the poor tumor differentiation, higher tumor invasion, greater degree of abdominal lymph node metastasis, and higher TNM and Duke stage tumors (all P-values < 0.01). CEA expression was associated with older ages (median age 65 years). Multivariate analysis indicated that CEA was correlated with overall survival and none of the markers correlated with disease recurrence. The expression of CEA, CA19-9, CA125, CYFRA21-1, and CA72-4 was associated with specific disease characteristics which tended to indicated more advanced disease and disease recurrence consistent with these biomarkers being useful for detecting colorectal cancer. PMID:24875250

  15. Commissioning of the Ground Test Accelerator RFQ

    SciTech Connect

    Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Connolly, R.; Garnett, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohson, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Saadatmand, K.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

    1992-09-01

    The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H{sup {minus}} beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 key H{sup {minus}} injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2{beta}{gamma} Drift Tube Linac (DTL-1) module, the 8.7 MeV 2{beta}{gamma} DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the RFQ beam experiments will be presented along with comparisons to simulations.

  16. Commissioning of the Ground Test Accelerator RFQ

    SciTech Connect

    Johnson, K.F.; Sander, O.R.; Atkins, W.H.; Bolme, G.O.; Brown, S.; Connolly, R.; Garnett, R.; Gilpatrick, J.D.; Guy, F.W.; Ingalls, W.B.; Little, C.; Lohson, R.A.; Lloyd, S.; Neuschaefer, G.; Power, J.; Saadatmand, K.; Sandoval, D.P.; Stevens, R.R.; Vaughn, G.; Wadlinger, E.A.; Weiss, R.; Yuan, V.

    1992-01-01

    The Ground Test Accelerator (GTA) has the objective of verifying much of the technology (physics and engineering) required for producing high-brightness, high-current H{sup {minus}} beams. GTA commissioning is staged to verify the beam dynamics design of each major accelerator component as it is brought on-line. The commissioning stages are the 35 key H{sup {minus}} injector, the 2.5 MeV Radio Frequency Quadrupole (RFQ), the Intertank Matching Section (IMS), the 3.2 MeV first 2{beta}{gamma} Drift Tube Linac (DTL-1) module, the 8.7 MeV 2{beta}{gamma} DTL (modules 1--5), and the 24 MeV GTA; all 10 DTL modules. Commissioning results from the RFQ beam experiments will be presented along with comparisons to simulations.

  17. VINCI: the VLT Interferometer commissioning instrument

    NASA Astrophysics Data System (ADS)

    Kervella, Pierre; Coudé du Foresto, Vincent; Glindemann, Andreas; Hofmann, Reiner

    2000-07-01

    The Very Large Telescope Interferometer (VLTI) is a complex system, made of a large number of separated elements. To prepare an early successful operation, it will require a period of extensive testing and verification to ensure that the many devices involved work properly together, and can produce meaningful data. This paper describes the concept chosen for the VLTI commissioning instrument, LEONARDO da VINCI, and details its functionalities. It is a fiber based two-way beam combiner, associated with an artificial star and an alignment verification unit. The technical commissioning of the VLTI is foreseen as a stepwise process: fringes will first be obtained with the commissioning instrument in an autonomous mode (no other parts of the VLTI involved); then the VLTI telescopes and optical trains will be tested in autocollimation; finally fringes will be observed on the sky.

  18. Commissioning an Elekta Versa HD linear accelerator.

    PubMed

    Narayanasamy, Ganesh; Saenz, Daniel; Cruz, Wilbert; Ha, Chul S; Papanikolaou, Niko; Stathakis, Sotirios

    2016-01-01

    The purpose of this study is to report the dosimetric aspects of commissioning performed on an Elekta Versa HD linear accelerator (linac) with high-dose-rate flattening filter-free (FFF) photon modes and electron modes. Acceptance and commissioning was performed on the Elekta Versa HD linac with five photon energies (6 MV, 10 MV, 18 MV, 6 MV FFF, 10 MV FFF), four electron energies (6 MeV, 9MeV, 12 MeV, 15 MeV) and 160-leaf (5 mm wide) multileaf collimators (MLCs). Mechanical and dosimetric data were measured and evaluated. The measurements include percent depth doses (PDDs), in-plane and cross-plane profiles, head scatter factor (Sc), relative photon output factors (Scp), universal wedge transmission factor, MLC transmission factors, and electron cone factors. Gantry, collimator, and couch isocentricity measurements were within 1 mm, 0.7 mm, and 0.7 mm diameter, respectively. The PDDs of 6 MV FFF and 10 MV FFF beams show deeper dmax and steeper falloff with depth than the corresponding flattened beams. While flatness values of 6 MV FFF and 10 MV FFF normalized profiles were expectedly higher than the corresponding flattened beams, the symmetry values were almost identical. The cross-plane penumbra values were higher than the in-plane penumbra values for all the energies. The MLC transmission values were 0.5%, 0.6%, and 0.6% for 6 MV, 10 MV, and 18 MV photon beams, respectively. The electron PDDs, profiles, and cone factors agree well with the literature. The outcome of radiation treatment is directly related to the accuracy in the dose modeled in the treatment planning system, which is based on the commissioned data. Commissioning data provided us a valuable insight into the dosimetric characteristics of the beam. This set of commissioning data can provide comparison data to others performing Versa HD commissioning, thereby improving patient safety. PMID:26894351

  19. Federal Energy Regulatory Commission`s fiscal year 1996 financial statement audit

    SciTech Connect

    1997-02-14

    This report presents the results of the independent certified public accountants` audit of the Federal Energy Regulatory Commission`s (FERC) financial statements as of September 30, 1996. The auditors have expressed an unqualified opinion on the 1996 statement of financial position and the related statements of operations and changes in net position.

  20. 75 FR 27981 - Codex Alimentarius Commission: Meeting of the Codex Alimentarius Commission

    Federal Register 2010, 2011, 2012, 2013, 2014

    2010-05-19

    ... Food Safety and Inspection Service Codex Alimentarius Commission: Meeting of the Codex Alimentarius Commission AGENCY: Office of Food Safety, USDA. ACTION: Notice of public meeting and request for comments. SUMMARY: The Office of Food Safety, U.S. Department of Agriculture (USDA), is sponsoring a public...