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Sample records for compatibility analysis ii

  1. EMC (electromagnetic compatibility) system test and analysis interface

    NASA Astrophysics Data System (ADS)

    Ball, E. F.; Knutson, L.; Carlson, B. L.

    1983-05-01

    One of the major problems in ensuring the electromagnetic compatibility (ECM) of a system is the efficient utilization of equipment level measurements and system level analysis tools. The contents of this report present an indepth evaluation of MIL-STD-461 and the United States Air Force's system level analysis tool, Intrasystem Electromagnetic Compatibility Analysis Program (IEMCAP). Recommended changes to improve system level ECM predictions based on equipment and system level test results are presented along with recommended changes to IEMCAP.

  2. MHC class II compatibility in aborted fetuses and term infants of couples with recurrent spontaneous abortion.

    PubMed

    Ober, C; Steck, T; van der Ven, K; Billstrand, C; Messer, L; Kwak, J; Beaman, K; Beer, A

    1993-12-01

    Maternal-fetal histocompatibility for alleles at HLA class II loci, HLA-DQA1 and HLA-DQB1, was examined in 40 abortuses and 31 liveborn children of 68 couples with a history of idiopathic recurrent spontaneous abortion (RSAB) who underwent leukocyte immunization prior to the index pregnancy. Significantly more couples with RSAB shared two HLA-DQA1 alleles as compared with fertile control couples (0.18 vs. 0.03, respectively; P = 0.031). There were no differences in HLA sharing between couples with RSAB who experienced a repeat abortion in the index pregnancy as compared with couples with RSAB who were delivered of a liveborn child. Non-significant deficits of abortuses who were compatible for alleles at the HLA-DQA1 (6 observed vs. 8.5 expected; P = 0.225) and the HLA-DQB1 (7 observed vs. 9.2 expected; P = 0.254) loci were observed. A significant deficit of HLA-DQA1 compatible liveborn children was observed (1 observed vs. 5.5 expected; P = 0.0069). The overall deficit of HLA-DQA1 compatible fetuses (7 observed vs. 14.0 expected; P = 0.0018) after approximately 8 weeks gestation suggests that HLA-DQA1 compatible fetuses may be aborted early in pregnancy, prior to the time when fetal tissue can be recovered for genetic studies. PMID:8207709

  3. Electromagnetic Compatibility Analysis Group VA-H3

    NASA Technical Reports Server (NTRS)

    Armanda, Carlos A.

    2008-01-01

    During the eight weeks working at NASA, I was fortunate enough to work with the Expendable Launch Vehicle's (ELV) Electromagnetic Compatibility (EMC) Team, who is responsible for the evaluation and analysis of any EMI risk an ELV mission might face. This group of people concern themselves with practically any form of electromagnetic interference that may risk the safety of a rocket, a mission, or even people. Taking this into consideration, the group investigates natural forms of interference, such as lightning, to manmade interferences, such as antennas.

  4. SAGE II Ozone Analysis

    NASA Technical Reports Server (NTRS)

    Cunnold, Derek; Wang, Ray

    2002-01-01

    Publications from 1999-2002 describing research funded by the SAGE II contract to Dr. Cunnold and Dr. Wang are listed below. Our most recent accomplishments include a detailed analysis of the quality of SAGE II, v6.1, ozone measurements below 20 km altitude (Wang et al., 2002 and Kar et al., 2002) and an analysis of the consistency between SAGE upper stratospheric ozone trends and model predictions with emphasis on hemispheric asymmetry (Li et al., 2001). Abstracts of the 11 papers are attached.

  5. Statistical analysis in dBASE-compatible databases.

    PubMed

    Hauer-Jensen, M

    1991-01-01

    Database management in clinical and experimental research often requires statistical analysis of the data in addition to the usual functions for storing, organizing, manipulating and reporting. With most database systems, transfer of data to a dedicated statistics package is a relatively simple task. However, many statistics programs lack the powerful features found in database management software. dBASE IV and compatible programs are currently among the most widely used database management programs. d4STAT is a utility program for dBASE, containing a collection of statistical functions and tests for data stored in the dBASE file format. By using d4STAT, statistical calculations may be performed directly on the data stored in the database without having to exit dBASE IV or export data. Record selection and variable transformations are performed in memory, thus obviating the need for creating new variables or data files. The current version of the program contains routines for descriptive statistics, paired and unpaired t-tests, correlation, linear regression, frequency tables, Mann-Whitney U-test, Wilcoxon signed rank test, a time-saving procedure for counting observations according to user specified selection criteria, survival analysis (product limit estimate analysis, log-rank test, and graphics), and normal t and chi-squared distribution functions. PMID:2004275

  6. Stormwater harvesting and WSUD frequent flow management: a compatibility analysis.

    PubMed

    Brodie, I

    2012-01-01

    Harvesting stormwater from urban catchments provides a supplementary water resource and, due to the physical abstraction of polluted water, also leads to environmental benefits. These benefits include the reduction of frequent ecosystem disturbance during small storms and less waterway erosion; hydrological impacts which are currently addressed by Water Sensitive Urban Design guidelines for stormwater frequent flow management (FFM). Although FFM and stormwater harvesting share the same store-release behaviour, they have a very different underlying basis to their design and operation. This paper explores the level of compatibility between these two systems and hence the potential for their integration. It was found by water balance analysis that the harvesting storage required to maximise most yields is similar to the recommended storage volume for FFM. This analysis was performed for a temperate-climate location in South East Queensland under historically low rainfalls. Environmental benefits associated with runoff quantity and pollutant load reductions are highest when the capture storage is rapidly emptied after storms. PMID:22744693

  7. Proteomics analysis of compatibility and incompatibility in grafted cucumber seedlings.

    PubMed

    Xu, Qing; Guo, Shi-Rong; Li, Lin; An, Ya-Hong; Shu, Sheng; Sun, Jin

    2016-08-01

    Graft compatibility between rootstock and scion is the most important factor influencing the survival of grafted plants. In this study, we used two-dimensional gel electrophoresis (2-DE) and matrix-assisted laser desorption/ionization tandem time-of-flight mass spectrometry (MALDI-TOF/TOF MS) to investigate differences in leaf proteomes of graft-compatible and graft-incompatible cucumber (Cucumis sativus L.)/pumpkin (Cucurbita L.) combinations. Cucumber seedlings were used as the scions and two pumpkin cultivars with strongly contrasting grafting compatibilities were used as the rootstocks. Non-grafted and self-grafted cucumber seedlings served as control groups. An average of approximately 500 detectable spots were observed on each 2-DE gel. A total of 50 proteins were differentially expressed in response to self-grafting, compatible-rootstock grafting, and incompatible-rootstock grafting and were all successfully identified by MALDI-TOF/TOF MS. The regulation of Calvin cycle, photosynthetic apparatus, glycolytic pathway, energy metabolism, protein biosynthesis and degradation, and reactive oxygen metabolism will probably contribute to intensify the biomass and photosynthetic capacity in graft-compatible combinations. The improved physiological and growth characteristics of compatible-rootstock grafting plants are the result of the higher expressions of proteins involved in photosynthesis, carbohydrate and energy metabolism, and protein metabolism. At the same time, the compatible-rootstock grafting regulation of stress defense, amino acid metabolism, and other metabolic functions also plays important roles in improvement of plant growth. PMID:27070289

  8. Compatibility conditions of structural mechanics for finite element analysis

    NASA Technical Reports Server (NTRS)

    Patnaik, Surya N.; Berke, Laszlo; Gallagher, Richard H.

    1990-01-01

    The equilibrium equations and the compatibility conditions are fundamental to the analyses of structures. However, anyone who undertakes even a cursory generic study of the compatibility conditions can discover, with little effort, that historically this facet of structural mechanics had not been adequately researched by the profession. Now the compatibility conditions (CC's) have been researched and are understood to a great extent. For finite element discretizations, the CC's are banded and can be divided into three distinct categories: (1) the interface CC's; (2) the cluster or field CC's; and (3) the external CC's. The generation of CC's requires the separating of a local region, then writing the deformation displacement relation (ddr) for the region, and finally, the eliminating of the displacements from the ddr. The procedure to generate all three types of CC's is presented and illustrated through examples of finite element models. The uniqueness of the CC's thus generated is shown.

  9. Compatible host/mycorrhizal fungus combinations for micropropagated sea oats: II. Field evaluation.

    PubMed

    Al Agely, Abid; Sylvia, David M

    2008-07-01

    Sea oats (Uniola paniculata L.) are the dominant plant in the pioneer coastal dunes of Florida and are widely used for dune restoration. DNA analysis has revealed significant ecotypic variation among Atlantic and Gulf coast populations of sea oats, but little is known about the diversity of the arbuscular mycorrhizal (AM) communities present in the dune systems. In a prior greenhouse study, we evaluated the functional diversity that exists among the AM fungal communities from divergent Florida dunes and selected effective host/AM fungus combinations for further study. The objective of this study was to evaluate the effect of these compatible combinations on the growth of sea oats planted at Anastasia State Recreation Area (AN) on the Atlantic coast and St. George Island State Park (SG) on the Gulf coast. Micropropagated sea oats from each site were inoculated with AM fungal communities also from AN and SG or a microbial filtrate control. The complete factorial of treatment combinations were grown in the greenhouse for 8 weeks and outplanted to the AN and SG field sites. After 1 year, root colonization was evaluated, and after 2 years, root colonization, shoot and root dry masses, and shoot- and root-P contents were determined. Overall, sea oats planted at AN had greater percent root colonization, shoot dry mass, and shoot-P content than those planted at SG. At AN, the local sea oat ecotype responded more to the fungal community from the same site relative to shoot dry mass and shoot-P content. At SG, the local fungal community produced larger plants with greater P content regardless of the origin of the host. We conclude that sea oat productivity is responsive to AM fungal ecotype as well as host ecotype, and fungal origin should therefore be taken into account when planning sea oat plantings on coastal dunes. PMID:18536940

  10. Virtual reality in construction industry: a requirement compatibility analysis approach

    NASA Astrophysics Data System (ADS)

    Ye, Jilin; Shulgin, Boris V.; Raja, Vinesh H.

    2006-02-01

    Virtual Reality (VR) is regarded as a high-end user-computer interface that involves real-time simulation and interactions through multiple sensorial channels. It is assumed that VR will reshape the interaction interfaces between user and computer technology by offering new approaches for the communication of information, the visualisation of processes and the creative expression of ideas. The VR application in construction has a relatively long history but its successful stories are not heard quite often. In this paper, the authors have explored how much further the construction industry could be supported by new three dimensional (3D) VR technologies in different construction processes. The design information in the construction industry has been discussed first followed by a detail construction process analysis. A questionnaire survey has been conducted and the results of the survey are presented and discussed. As an investigation into the application of 3D VR technologies in the context of the construction processes, the benefits and challenges of current and potential applications of 3D VR in the construction industry have been identified. This study also reveals the strengths and weaknesses of 3D VR technology applications in the construction processes. Suggestions and future works are also provided in this paper.

  11. Solid phase microextraction analysis of B83 SLTS and Core B compatibility test units

    SciTech Connect

    Chambers, D M; Ithaca, J; King, H A; Malcolm, S

    1999-03-26

    Solid phase microextraction has permitted the efficient collection and analysis of a broad range of volatile and semivolatile compounds outgassed from materials. In 1998, we implemented a microextraction protocol at Mason and Hanger, Pantex Plant, for the analysis of weapons and compatibility test units. The chemical information that was obtained from this work is interpreted by determining the source and outgas mechanism for each compound in the weapon signature, which is a task only accomplished by analysis of material standards.

  12. Thermal behaviour of procaine and benzocaine Part II: compatibility study with some pharmaceutical excipients used in solid dosage forms

    PubMed Central

    2013-01-01

    Background The compatibility study of active substances with excipients finds an important role in the domain of pharmaceutical research, being known the fact that final formulation is the one administered to the patient. In order to evaluate the compatibility between active substance and excipients, different analytical techniques can be used, based on their accuracy, reproducibility and fastness. Results Compatibility study of two well-known active substances, procaine and benzocaine, with four commonly used excipients, was carried out employing thermal analysis (TG/DTG/HF) and Fourier Transform Infrared Spectroscopy (UATR-FT-IR). The selected excipients were microcrystalline cellulose, lactose monohydrate, magnesium stearate and talc. Equal proportion of active substance and excipients (w/w) was utilized in the interaction study. The absolute value of the difference between the melting point peak of active substances and the one corresponding for the active substances in the analysed mixture, as well the absolute value of the difference between the enthalpy of the pure active ingredient melting peak and that of its melting peak in the different analysed mixtures were chosen as indexes of the drug-excipient interaction degree. All the results obtained through thermal analysis were also sustained by FT-IR spectroscopy. Conclusions The corroboration of data obtained by thermal analysis with the ones from FT-IR spectroscopy indicated that no interaction occurs between procaine and benzocaine, with microcrystalline cellulose and talc, as well for the benzocaine-lactose mixture. Interactions were confirmed between procaine and benzocaine respectively and magnesium stearate, and for procaine and lactose. PMID:23962059

  13. Molecularly Engineered Ru(II) Sensitizers Compatible with Cobalt(II/III) Redox Mediators for Dye-Sensitized Solar Cells.

    PubMed

    Wu, Kuan-Lin; Huckaba, Aron J; Clifford, John N; Yang, Ya-Wen; Yella, Aswani; Palomares, Emilio; Grätzel, Michael; Chi, Yun; Nazeeruddin, Mohammad Khaja

    2016-08-01

    Thiocyanate-free isoquinazolylpyrazolate Ru(II) complexes were synthesized and applied as sensitizers in dye-sensitized solar cells (DSCs). Unlike most other successful Ru sensitizers, Co-based electrolytes were used, and resulting record efficiency of 9.53% was obtained under simulated sunlight with an intensity of 100 mW cm(-2). Specifically, dye 51-57dht.1 and an electrolyte based on Co(phen)3 led to measurement of a JSC of 13.89 mA cm(-2), VOC of 900 mV, and FF of 0.762 to yield 9.53% efficiency. The improved device performances were achieved by the inclusion of 2-hexylthiophene units onto the isoquinoline subunits, in addition to lengthening the perfluoroalkyl chain on the pyrazolate chelating group, which worked to increase light absorption and decrease recombination effects when using the Co-based electrolyte. As this study shows, Ru(II) sensitizers bearing sterically demanding ligands can allow successful utilization of important Co electrolytes and high performance. PMID:27420188

  14. Mating Compatibility and Restriction Analysis of Ganoderma Isolates from Oil Palm and Other Palm Hosts.

    PubMed

    Jing, Chan Jer; Seman, Idris Abu; Zakaria, Latiffah

    2015-12-01

    Mating compatibility and restriction analyses of Internal Transcribed Spacer (ITS) regions were performed to determine the relations between Ganoderma boninense, the most common species associated with basal stem rot in oil palm and Ganoderma isolates from infected oil palm, two ornamental palms, sealing wax palm (Cyrtostachys renda) and MacArthur palm (Ptychosperma macarthurii), an isolate from coconut stump (Cocos nucifera), Ganoderma miniatocinctum, Ganoderma zonatum and Ganoderma tornatum. The results showed that G. boninense was compatible with Ganoderma isolates from oil palm, G. miniatocinctum and G. zonatum, Ganoderma isolates from sealing wax palm, MacArthur palm and coconut stump. G. boninense was not compatible with G. tornatum. Therefore, the results suggested that the G. boninense, G. miniatocinctum, G. zonatum, and Ganoderma isolates from oil palm, ornamental palms and coconut stump could represent the same biological species. In performing a restriction analysis of the ITS regions, variations were observed in which five haplotypes were generated from the restriction patterns. An unweighted pair-group method with arithmetic averages (UPGMA) cluster analysis showed that all the Ganoderma isolates were grouped into five primary groups, and the similarity values of the isolates ranged from 97% to 100%. Thus, a restriction analysis of the ITS regions showed that G. boninense and the Ganoderma isolates from other palm hosts were closely related. On the basis of the mating compatibility test and the restriction analysis of the ITS regions performed in this study, a diverse group of Ganoderma species from oil palm and other palm hosts are closely related, except for G. tornatum and Ganoderma isolates from tea and rubber. PMID:26868709

  15. Conversion of the Aerodynamic Preliminary Analysis System (APAS) to an IBM PC Compatible Format

    NASA Technical Reports Server (NTRS)

    Kruep, John M.

    1995-01-01

    The conversion of the Aerodynamic Preliminary Analysis System (APAS) software from a Silicon Graphics UNIX-based platform to a DOS-based IBM PC compatible is discussed. Relevant background information is given, followed by a discussion of the steps taken to accomplish the conversion and a discussion of the type of problems encountered during the conversion. A brief comparison of aerodynamic data obtained using APAS with data from another source is also made.

  16. Mating Compatibility and Restriction Analysis of Ganoderma Isolates from Oil Palm and Other Palm Hosts

    PubMed Central

    Jing, Chan Jer; Seman, Idris Abu; Zakaria, Latiffah

    2015-01-01

    Mating compatibility and restriction analyses of Internal Transcribed Spacer (ITS) regions were performed to determine the relations between Ganoderma boninense, the most common species associated with basal stem rot in oil palm and Ganoderma isolates from infected oil palm, two ornamental palms, sealing wax palm (Cyrtostachys renda) and MacArthur palm (Ptychosperma macarthurii), an isolate from coconut stump (Cocos nucifera), Ganoderma miniatocinctum, Ganoderma zonatum and Ganoderma tornatum. The results showed that G. boninense was compatible with Ganoderma isolates from oil palm, G. miniatocinctum and G. zonatum, Ganoderma isolates from sealing wax palm, MacArthur palm and coconut stump. G. boninense was not compatible with G. tornatum. Therefore, the results suggested that the G. boninense, G. miniatocinctum, G. zonatum, and Ganoderma isolates from oil palm, ornamental palms and coconut stump could represent the same biological species. In performing a restriction analysis of the ITS regions, variations were observed in which five haplotypes were generated from the restriction patterns. An unweighted pair-group method with arithmetic averages (UPGMA) cluster analysis showed that all the Ganoderma isolates were grouped into five primary groups, and the similarity values of the isolates ranged from 97% to 100%. Thus, a restriction analysis of the ITS regions showed that G. boninense and the Ganoderma isolates from other palm hosts were closely related. On the basis of the mating compatibility test and the restriction analysis of the ITS regions performed in this study, a diverse group of Ganoderma species from oil palm and other palm hosts are closely related, except for G. tornatum and Ganoderma isolates from tea and rubber. PMID:26868709

  17. Proteomic analysis of the compatible interaction between Vitis vinifera and Plasmopara viticola.

    PubMed

    Milli, Alberto; Cecconi, Daniela; Bortesi, Luisa; Persi, Anna; Rinalducci, Sara; Zamboni, Anita; Zoccatelli, Gianni; Lovato, Arianna; Zolla, Lello; Polverari, Annalisa

    2012-02-01

    We analyzed the proteome of grapevine (Vitis vinifera) leaves 24, 48 and 96 h post infection (hpi) with the downy mildew pathogen Plasmopara viticola. Total proteins were separated on 2-DE gels. By MS analysis, we identified 82 unique grapevine proteins differentially expressed after infection. Upregulated proteins were often included in the functional categories of general metabolism and stress response, while proteins related to photosynthesis and energy production were mostly downregulated. As expected, the activation of a defense reaction was observed more often at the late time point, consistent with the establishment of a compatible interaction. Most proteins involved in resistance were isoforms of different PR-10 pathogenesis-related proteins. Although >50 differentially expressed protein isoforms were observed at 24 and 96 hpi, only 18 were detected at 48 hpi and no defense-related proteins were among this group. This profile suggests a transient breakdown in defense responses accompanying the onset of disease, further supported by gene expression analyses and by a western blot analysis of a PR-10 protein. Our data reveal the complex modulation of plant metabolism and defense responses during compatible interactions, and provide insight into the underlying molecular processes which may eventually yield novel strategies for pathogen control in the field. PMID:22120121

  18. Development of intensity compatible time-histories for dynamic analysis of structures

    NASA Astrophysics Data System (ADS)

    Klügel, Jens-Uwe; Akcay Stäuble, Sunay

    2016-04-01

    The assessment of the functionality of critical infrastructures and lifelines after an earthquake strongly depends on an accurate assessment of the degree of damage exhibited during the earthquake. Usual engineering parameters like linear-elastic response spectra or linear-elastic uniform hazard spectra in terms of spectral accelerations are not suitable for predicting damage because the process of damaging is a non-linear process. The only seismological parameter that implicitly contains the required information on the damaging impact of earthquakes is intensity. This parameter in different scales (EMS-98, MSK-64, MMI) is directly linked to physical observations including the damage of buildings. Additionally, intensity information directly captures spatial variation of ground motions related to the same or similar degree damage by construction of isoseismal lines. Therefore intensities are very suitable for predicting possible impacts of earthquakes on critical infrastructures or lifelines. For engineering applications intensity relevant information has to be converted into engineering characteristics. Because dynamic analyses (time-history analysis, frequently even nonlinear ones) became a standard approach for the design and for the validation of safety of critical infrastructures and lifelines it is reasonable to develop intensity-compatible time-histories for engineering application as an alternative to standard methods. In the paper an approach how to develop intensity-compatible time-histories from recorded time-histories is presented. Based on published international data a set of intensity compatible time-histories covering the site intensity range between intensity V and VIII (EMS scale) is developed. The time-histories developed are compared with typical time-histories derived from spectral matching of a uniform hazard spectrum from a large scale PSHA corresponding to approximately the same intensity class. For this comparison in-structure floor

  19. The REFLEX II galaxy cluster survey: power spectrum analysis

    NASA Astrophysics Data System (ADS)

    Balaguera-Antolínez, A.; Sánchez, Ariel G.; Böhringer, H.; Collins, C.; Guzzo, L.; Phleps, S.

    2011-05-01

    We present the power spectrum of galaxy clusters measured from the new ROSAT-ESO Flux-Limited X-Ray (REFLEX II) galaxy cluster catalogue. This new sample extends the flux limit of the original REFLEX catalogue to 1.8 × 10-12 erg s-1 cm-2, yielding a total of 911 clusters with ≥94 per cent completeness in redshift follow-up. The analysis of the data is improved by creating a set of 100 REFLEX II-catalogue-like mock galaxy cluster catalogues built from a suite of large-volume Λ cold dark matter (ΛCDM) N-body simulations (L-BASICC II). The measured power spectrum is in agreement with the predictions from a ΛCDM cosmological model. The measurements show the expected increase in the amplitude of the power spectrum with increasing X-ray luminosity. On large scales, we show that the shape of the measured power spectrum is compatible with a scale-independent bias and provide a model for the amplitude that allows us to connect our measurements with a cosmological model. By implementing a luminosity-dependent power-spectrum estimator, we observe that the power spectrum measured from the REFLEX II sample is weakly affected by flux-selection effects. The shape of the measured power spectrum is compatible with a featureless power spectrum on scales k > 0.01 h Mpc-1 and hence no statistically significant signal of baryonic acoustic oscillations can be detected. We show that the measured REFLEX II power spectrum displays signatures of non-linear evolution.

  20. Compatibility of refrigerants and lubricants with motor materials under retrofit conditions. Final report, Volume II - data tables, high pressure refrigerants

    SciTech Connect

    Doerr, R.G.; Waite, T.D.

    1996-10-01

    Compatibility tests were conducted on motor materials to determine if exposure to the original refrigerant/mineral oil would affect compatibility of the motor materials after retrofit to the alternative refrigerant/lubricant. The motor materials were exposed at elevated temperature to the original refrigerant and mineral oil for 500 hours, followed by exposure to the alternative refrigerant and lubricant for 500 hours. Measurements were also taken after 168 and 336 hours. As a control, some samples were exposed to the original refrigerant/mineral oil for a total of 1000 hours.

  1. Towards Making a LEON3 Multicore Compatible with Probabilistic Timing Analysis

    NASA Astrophysics Data System (ADS)

    Hernandez, Carles; Abella, Jaume; Cazorla, Francisco J.; Andersson, Jan; Gianarro, Andrea

    2015-09-01

    Timing analysis must be performed for safetycritical real-time tasks to estimate their Worst-Case Execution Time (WCET). The advent of multicores and cache hierarchies challenges the use of traditional measurement-based timing analysis (MBTA), which is current practice in industry. To tackle this issue a new family of timing analysis techniques based on probabilistic analysis has recently arised. Among those, Measurement-Based Probabilistic Timing Analysis (MBPTA) is the most promising approach, but imposes some constraints on the hardware design. In this paper we analyze the case of a LEON3 multicore processor, identify those features that need to be modified to attain MBPTA compliance and show the first steps towards achieving it. Our preliminary results show that (i) low WCET estimates can be derived, (ii) industrial practice based on measurements can be kept, and (iii) average performance is only slightly harmed w.r.t. non-MBPTA-compliant hardware designs.

  2. Thermodynamic analysis of compatibility of several reinforcement materials with beta phase NiAl alloys

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1988-01-01

    Chemical compatibility of several reinforcement materials with beta phase NiAl alloys within the concentration range 40 to 50 at. percent Al have been analyzed from thermodynamic considerations at 1373 and 1573 K. The reinforcement materials considered in this study include carbides, borides, oxides, nitrides, beryllides, and silicides. Thermodynamic data for NiAl alloys have been reviewed and activity of Ni and Al in the beta phase have been derived at 1373 and 1573 K. Criteria for chemical compatibility between the reinforcement material and the matrix have been defined and several chemically compatible reinforcement materials have been defined.

  3. Thermodynamic analysis of chemical compatibility of ceramic reinforcement materials with niobium aluminides

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1990-01-01

    Chemical compatibility of several reinforcement materials with three niobium aluminides, Nb3Al, Nb2Al, and NbAl3, were examined from thermodynamic considerations. The reinforcement materials considered in this study include carbides, borides, nitrides, oxides, silicides, and Engel-Brewer compounds. Thermodynamics of the Nb-Al system were reviewed and activities of Nb and Al were derived at desired calculation temperatures. Criteria for chemical compatibility between the reinforcement material and Nb-Al compounds have been defined and several chemically compatible reinforcement materials have been identified.

  4. Thermodynamic analysis of chemical compatibility of several reinforcement materials with niobium aluminides

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1989-01-01

    Chemical compatibility of several reinforcement materials with three niobium aluminides, Nb3Al, Nb2Al, and NbAl3, were examined from thermodynamic considerations. The reinforcement materials considered in this study include carbides, borides, nitrides, oxides, silicides, and Engel-Brewer compounds. Thermodynamics of the Nb-Al system were reviewed and activities of Nb and Al were derived at desired calculation temperatures. Criteria for chemical compatibility between the reinforcement material and Nb-Al compounds have been defined and several chemically compatible reinforcement materials have been identified.

  5. Thermodynamic analysis of chemical compatibility of several compounds with Fe-Cr-Al alloys

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1993-01-01

    Chemical compatibility between Fe-19.8Cr-4.8Al (weight percent), which is the base composition for the commercial superalloy MA956, and several carbides, borides, nitrides, oxides, and silicides was analyzed from thermodynamic considerations. The effect of addition of minor alloying elements, such as Ti, Y, and Y2O3, to the Fe-Cr-Al alloy on chemical compatibility between the alloy and various compounds was also analyzed. Several chemically compatible compounds that can be potential reinforcement materials and/or interface coating materials for Fe-Cr-Al based composites were identified.

  6. The Transcriptome of Compatible and Incompatible Interactions of Potato (Solanum tuberosum) with Phytophthora infestans Revealed by DeepSAGE Analysis

    PubMed Central

    Gyetvai, Gabor; Sønderkær, Mads; Göbel, Ulrike; Basekow, Rico; Ballvora, Agim; Imhoff, Maren; Kersten, Birgit; Nielsen, Kåre-Lehman; Gebhardt, Christiane

    2012-01-01

    Late blight, caused by the oomycete Phytophthora infestans, is the most important disease of potato (Solanum tuberosum). Understanding the molecular basis of resistance and susceptibility to late blight is therefore highly relevant for developing resistant cultivars, either by marker-assissted selection or by transgenic approaches. Specific P. infestans races having the Avr1 effector gene trigger a hypersensitive resistance response in potato plants carrying the R1 resistance gene (incompatible interaction) and cause disease in plants lacking R1 (compatible interaction). The transcriptomes of the compatible and incompatible interaction were captured by DeepSAGE analysis of 44 biological samples comprising five genotypes, differing only by the presence or absence of the R1 transgene, three infection time points and three biological replicates. 30.859 unique 21 base pair sequence tags were obtained, one third of which did not match any known potato transcript sequence. Two third of the tags were expressed at low frequency (<10 tag counts/million). 20.470 unitags matched to approximately twelve thousand potato transcribed genes. Tag frequencies were compared between compatible and incompatible interactions over the infection time course and between compatible and incompatible genotypes. Transcriptional changes were more numerous in compatible than in incompatible interactions. In contrast to incompatible interactions, transcriptional changes in the compatible interaction were observed predominantly for multigene families encoding defense response genes and genes functional in photosynthesis and CO2 fixation. Numerous transcriptional differences were also observed between near isogenic genotypes prior to infection with P. infestans. Our DeepSAGE transcriptome analysis uncovered novel candidate genes for plant host pathogen interactions, examples of which are discussed with respect to possible function. PMID:22328937

  7. A Materials Compatibility and Thermal Stability Analysis of Common Hydrocarbon Fuels

    NASA Technical Reports Server (NTRS)

    Meyer, M. L.; Stiegemeier, B. R.

    2005-01-01

    A materials compatibility and thermal stability investigation was conducted using five common liquid hydrocarbon fuels and two structural materials. The tests were performed at the NASA Glenn Research Center Heated Tube Facility under environmental conditions similar to those encountered in regeneratively cooled rocket engines. Scanning-electron microscopic analysis in conjunction with energy dispersive spectroscopy (EDS) was utilized to characterize the condition of the tube inner wall surface and any carbon deposition or corrosion that was formed during selected runs. Results show that the carbon deposition process in stainless steel tubes was relatively insensitive to fuel type or test condition. The deposition rates were comparable for all fuels and none of the stainless steel test pieces showed any signs of corrosion. For tests conducted with copper tubing, the sulfur content of the fuel had a significant impact on both the condition of the tube wall and carbon deposition rates. Carbon deposition rates for the lowest sulfur fuels (2 ppm) were slightly higher than those recorded in the stainless steel tubes with no corrosion observed on the inner wall surface. For slightly higher sulfur content (25 ppm) fuels, nodules that intruded into the flow area were observed to form on the inner wall surface. These nodules induced moderate tube pressure drop increases. The highest sulfur content fuels (400 ppm) produced extensive wall pitting and dendritic copper sulfide growth that was continuous along the entire tube wall surface. The result of this tube degradation was the inability to maintain flow rate due to rapidly increasing test section pressure drops. Accompanying this corrosion were carbon deposition rates an order of magnitude greater than those observed in comparable stainless steel tests. The results of this investigation indicate that trace impurities in fuels (i.e. sulfur) can significantly impact the carbon deposition process and produce unacceptable

  8. Soil Analysis Micro-Mission Concepts Derived from the MSP 2001 Mars Environmental Compatibility Assessment (MECA)

    NASA Technical Reports Server (NTRS)

    Hecht, M. H.; Meloy, T. P.; Anderson, M. S.; Buehler, M. G.; Frant, M. A.; Grannan, S. M.; Fuerstenau, S. D.; Keller, H. U.; Markiewicz, W. J.; Marshall, J.

    1999-01-01

    The Mars Environmental Compatibility Assessment (MECA) will evaluate the Martian environment for soil and dust-related hazards to human exploration as part of the Mars Surveyor Program 2001 Lander. The integrated MECA payload contains a wet-chemistry laboratory, a microscopy station, an electrometer to characterize the electrostatic environment, and arrays of material patches to study abrasion and adhesion. Heritage will be all-important for low cost micro-missions, and adaptations of instruments developed for the Pathfinder, '98 and '01 Landers should be strong contenders for '03 flights. This talk has three objectives: (1) Familiarize the audience with MECA instrument capabilities; (2) present concepts for stand-alone and/or mobile versions of MECA instruments; and (3) broaden the context of the MECA instruments from human exploration to a comprehensive scientific survey of Mars. Due to time limitations, emphasis will be on the chemistry and microscopy experiments. Ion-selective electrodes and related sensors in MECA's wet-chemistry laboratory will evaluate total dissolved solids, redox potential, pH, and the concentration of many soluble ions and gases in wet Martian soil. These electrodes can detect potentially dangerous heavy-metal ions, emitted pathogenic gases, and the soil's corrosive potential, and experiments will include cyclic voltammetry and anodic stripping. For experiments beyond 2001, enhancements could allow multiple use of the cells (for mobile experiments) and reagent addition (for quantitative mineralogical and exobiological analysis). MECA's microscopy station combines optical and atomic-force microscopy (AFM) in an actively focused, controlled illumination environment to image particles from millimeters to nanometers in size. Careful selection of substrates allows controlled experiments in adhesion, abrasion, hardness, aggregation, magnetic and other properties. Special tools allow primitive manipulation (brushing and scraping) of samples

  9. Thermodynamic analysis of compatibility of several reinforcement materials with FeAl alloys

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1988-01-01

    Chemical compatibility of several reinforcement materials with FeAl alloys within the concentration range 40 to 50 at pct Al have been analyzed from thermodynamic considerations at 1173 and 1273 K. The reinforcement materials considered in this study include carbides, borides, oxides, nitrides, and silicides. Although several chemically compatible reinforcement materials are identified, the coefficients of thermal expansion for none of these materials match closely with that of FeAl alloys and this might pose serious problems in the design of composite systems based on FeAl alloys.

  10. Task Analysis Inventories. Series II.

    ERIC Educational Resources Information Center

    Wesson, Carl E.

    This second in a series of task analysis inventories contains checklists of work performed in twenty-two occupations. Each inventory is a comprehensive list of work activities, responsibilities, educational courses, machines, tools, equipment, and work aids used and the products produced or services rendered in a designated occupational area. The…

  11. Effect of water structure on blood compatibility--thermal analysis of water in poly(meth)acrylate.

    PubMed

    Tanaka, Masaru; Mochizuki, Akira

    2004-03-15

    The purpose of this study is to clarify the main factor causing excellent blood compatibility of poly(2-methoxyethyl acrylate)(PMEA) by the comparison between PMEA and seven PMEA analogous polymers. The polymers have a typical functional group as ester side chains such as methoxyethyl, hydroxyethyl, phenoxyethyl, and alkyl groups. The properties of the polymers relating to water were investigated in terms of contact angle, equilibrium water content (EWC), and thermal analysis by differential scanning calorimetry. The water in PMEA could be classified into three types: nonfreezing water, freezing bound water, and free water while the water in the analogous polymers was classified into just two types: free and nonfreezing waters, regardless of the chemical structure of the side chain. The surface property represented by the contact angle of water corresponded to the content of the bound water (nonfreezing water + freezing bound water). The platelet compatibility in vitro did not depend on the contents of these waters, or on the contact angle. On the basis of the results of this work and the previous work on the platelet compatibility of poly(MEA-co-HEMA) (Tanaka et al. Biomacromolecules 2002;3;36-41), the main factor causing the excellent compatibility of PMEA is discussed. PMID:14986323

  12. Comparative analysis of microarray data in Arabidopsis transcriptome during compatible interactions with plant viruses

    Technology Transfer Automated Retrieval System (TEKTRAN)

    To analyze transcriptome response to virus infection, we have assembled currently available microarray data on changes in gene expression levels in compatible Arabidopsis-virus interactions. We used the mean r (Pearson’s correlation coefficient) for neighboring pairs to estimate pairwise local simil...

  13. Summary of CPAS Gen II Parachute Analysis

    NASA Technical Reports Server (NTRS)

    Morris, Aaron L.; Bledsoe, Kristin J.; Fraire, Usbaldo, Jr.; Moore, James W.; Olson, Leah M.; Ray, Eric

    2011-01-01

    The Orion spacecraft is currently under development by NASA and Lockheed Martin. Like Apollo, Orion will use a series of parachutes to slow its descent and splashdown safely. The Orion parachute system, known as the CEV Parachute Assembly System (CPAS), is being designed by NASA, the Engineering and Science Contract Group (ESCG), and Airborne Systems. The first generation (Gen I) of CPAS testing consisted of thirteen tests and was executed in the 2007-2008 timeframe. The Gen I tests provided an initial understanding of the CPAS parachutes. Knowledge gained from Gen I testing was used to plan the second generation of testing (Gen II). Gen II consisted of six tests: three singleparachute tests, designated as Main Development Tests, and three Cluster Development Tests. Gen II required a more thorough investigation into parachute performance than Gen I. Higher fidelity instrumentation, enhanced analysis methods and tools, and advanced test techniques were developed. The results of the Gen II test series are being incorporated into the CPAS design. Further testing and refinement of the design and model of parachute performance will occur during the upcoming third generation of testing (Gen III). This paper will provide an overview of the developments in CPAS analysis following the end of Gen I, including descriptions of new tools and techniques as well as overviews of the Gen II tests.

  14. Integrated Data Collection Analysis (IDCA) Program - Mixing Procedures and Materials Compatibility

    SciTech Connect

    Olinger, Becky D.; Sandstrom, Mary M.; Warner, Kirstin F.; Sorensen, Daniel N.; Remmers, Daniel L.; Moran, Jesse S.; Shelley, Timothy J.; Whinnery, LeRoy L.; Hsu, Peter C.; Whipple, Richard E.; Kashgarian, Michaele; Reynolds, John G.

    2011-01-14

    Three mixing procedures have been standardized for the IDCA proficiency test—solid-solid, solid-liquid, and liquid-liquid. Due to the variety of precursors used in formulating the materials for the test, these three mixing methods have been designed to address all combinations of materials. Hand mixing is recommended for quantities less than 10 grams and Jar Mill mixing is recommended for quantities over 10 grams. Consideration must also be given to the type of container used for the mixing due to the wide range of chemical reactivity of the precursors and mixtures. Eight web site sources from container and chemical manufacturers have been consulted. Compatible materials have been compiled as a resource for selecting containers made of materials stable to the mixtures. In addition, container materials used in practice by the participating laboratories are discussed. Consulting chemical compatibility tables is highly recommended for each operation by each individual engaged in testing the materials in this proficiency test.

  15. Integrated force method - Compatibility conditions of structural mechanics for finite element analysis

    NASA Technical Reports Server (NTRS)

    Patnaik, Surya N.; Berke, Laszlo; Gallagher, Richard H.

    1991-01-01

    The equilibrium equations and the compatibility conditions are fundamental to the analyses of structures. However, anyone who undertakes even a cursory generic study of the compatibility conditions can discover, with little effort, that historically this facet of structural mechanics had not been adequately researched by the profession. Now the compatibility conditions (CC's) have been researched and are understood to a great extent. For finite element discretizations, the CC's are banded and can be divided into three distinct categories: (1) the interface CC's, (2) the cluster or field CC's, and (3) the external CC's. The generation of CC's requires the separating of a local region, then writing the deformation displacement relation (ddr) for the region, and finally, the eliminating of the displacements from the ddr. The procedure to generate all three types of CC's is presented and illustrated through examples of finite element models. The uniqueness of the CC's thus generated is shown. The utilization of CC's has resulted in the novel integrated force method (IFM). The solution that is obtained by the IFM converges with a significantly fewer number of elements, compared to the stiffness and the hybrid methods.

  16. Fast and accurate single-cell RNA-seq analysis by clustering of transcript-compatibility counts.

    PubMed

    Ntranos, Vasilis; Kamath, Govinda M; Zhang, Jesse M; Pachter, Lior; Tse, David N

    2016-01-01

    Current approaches to single-cell transcriptomic analysis are computationally intensive and require assay-specific modeling, which limits their scope and generality. We propose a novel method that compares and clusters cells based on their transcript-compatibility read counts rather than on the transcript or gene quantifications used in standard analysis pipelines. In the reanalysis of two landmark yet disparate single-cell RNA-seq datasets, we show that our method is up to two orders of magnitude faster than previous approaches, provides accurate and in some cases improved results, and is directly applicable to data from a wide variety of assays. PMID:27230763

  17. Compatible solutes

    PubMed Central

    Hill, Colin

    2010-01-01

    Recently we reported a role for compatible solute uptake in mediating bile tolerance and increased gastrointestinal persistence in the foodborne pathogen Listeria monocytogenes.1 Herein, we review the evolution in our understanding of how these low molecular weight molecules contribute to growth and survival of the pathogen both inside and outside the body, and how this stress survival mechanism may ultimately be used to target and kill the pathogen. PMID:21326913

  18. Finite state model and compatibility theory - New analysis tools for permutation networks

    NASA Technical Reports Server (NTRS)

    Huang, S.-T.; Tripathi, S. K.

    1986-01-01

    A simple model to describe the fundamental operation theory of shuffle-exchange-type permutation networks, the finite permutation machine (FPM), is described, and theorems which transform the control matrix result to a continuous compatible vector result are developed. It is found that only 2n-1 shuffle exchange passes are necessary, and that 3n-3 passes are sufficient, to realize all permutations, reducing the sufficient number of passes by two from previous results. The flexibility of the approach is demonstrated by the description of a stack permutation machine (SPM) which can realize all permutations, and by showing that the FPM corresponding to the Benes (1965) network belongs to the SPM. The FPM corresponding to the network with two cascaded reverse-exchange networks is found to realize all permutations, and a simple mechanism to verify several equivalence relationships of various permutation networks is discussed.

  19. Analysis of S-locus and expression of S-alleles of self-compatible rapid-cycling Brassica oleracea 'TO1000DH3'.

    PubMed

    Hee-Jeong, Jung; Nasar Uddin, Ahmed; Jong-In, Park; Senthil Kumar, Thamilarasan; Hye-Ran, Kim; Yong-Gu, Cho; Ill-Sup, Nou

    2014-10-01

    Brassica oleracea is a strictly self-incompatible (SI) plant, but rapid-cycling B. oleracea 'TO1000DH3' is self-compatible (SC). Self-incompatibility in Brassicaceae is controlled by multiple alleles of the S-locus. Three S-locus genes, S-locus glycoprotein (SLG), S-locus receptor kinase (SRK) and S-locus protein 11 or S-locus cysteine-rich (SP11/SCR), have been reported to date, all of which are classified into class I and II. In this study, we investigated the molecular mechanism behind alterations of SI to SC in rapid-cycling B. olerace 'TO1000DH3'. Class I SRK were identified by genomic DNA PCR and PCR-RFLP analysis using SRK specific markers and found to be homozygous. Cloning and sequencing of class I SRK revealed a normal kinase domain without any S-domain/transmembrane domain. Moreover, S-locus sequencing analysis revealed only an SLG sequence, but no SP11/SCR. Expression analysis showed no SRK expression in the stigma, although other genes involved in the SI recognition reaction (SLG, MLPK, ARC1, THL) were found to have normal expression in the stigma. Taken together, the above results suggest that structural aberrations such as deletion of the SI recognition genes may be responsible for the breakdown of SI in rapid-cycling B. oleracea 'TO1000DH3'. PMID:24969488

  20. In Vivo Detection of Oxidation-Specific Epitopes in Atherosclerotic Lesions Using Bio-Compatible Mn(II) Molecular Magnetic Imaging Probes

    PubMed Central

    Briley-Saebo, Karen C.; Hoang, Tuyen; Saeboe, Alexander M.; Cho, Young Seok; Ryu, Sung Kee; Volkava, Eugenia; Dickson, Stephen; Leibundgut, Gregor; Weisner, Philipp; Green, Simone; Casanada, Florence; Miller, Yury I.; Shaw, Walter; Witztum, Joseph L; Fayad, Zahi A.; Tsimikas, Sotirios

    2012-01-01

    Objectives To evaluate the in vivo magnetic resonance (MR) imaging efficacy of manganese (Mn(II)) molecular imaging probes targeted to oxidation-specific epitopes (OSE). Background OSE are critical in the initiation, progression and de-stabilization of atherosclerotic plaques. Gadolinium (Gd(III)) based MR imaging agents can be associated with systemic toxicity. Mn is an endogenous, bio-compatible, paramagnetic metal ion that has poor MR efficacy when chelated, but strong efficacy when released within cells. Methods Multimodal Mn-micelles were generated to contain rhodamine for confocal microscopy and conjugated with either the murine monoclonal IgG antibody MDA2 targeted to malondialdehyde (MDA)-lysine epitopes or the human single-chain Fv antibody fragment IK17 targeted to MDA-like epitopes (‘targeted micelles”). Micelle formulations were characterized in vitro and in vivo and their MR efficacy (9.4 Tesla) evaluated in apoE−/− and LDLR−/− mice (0.05 mmol Mn/Kg dose) (total of 120 mice for all experiments). In vivo competitive inhibition studies were performed to evaluate target specificity. Untargeted, MDA2-Gd and IK17-Gd micelles (0.075 mmol Gd/Kg) were included as controls. Results In vitro studies demonstrated that targeted Mn-micelles accumulate in macrophages when pre-exposed to MDA-LDL with ~10X increase in longitudinal relativity. Following intravenous injection, strong MR signal enhancement was observed 48–72 hours after administration of targeted Mn-micelles, with co-localization within intraplaque macrophages. Co-injection of free MDA2 with the MDA2-Mn micelles resulted in full suppression of MR signal in the arterial wall confirming target specificity. Similar MR efficacy was noted in apoE−/− and LDLR−/− mice with aortic atherosclerosis. No significant differences in MR efficacy were noted between targeted Mn and Gd micelles. Conclusions This study demonstrates that bio-compatible multimodal Mn-based molecular imaging probes

  1. LCLS-II Undulator Tolerance Analysis

    SciTech Connect

    Nuhn, H.-D.; Marks, S.; Wu, J.; /SLAC

    2012-06-06

    The SLAC National Accelerator Laboratory is building a new FEL user facility, LCLS-II, as a major upgrade to the Linear Coherent Light Source (LCLS). The upgrade will include two new Free Electron Lasers (FELs), to generate soft (SXR) and hard x-ray (HXR) SASE FEL radiation, based on planar, variable gap hybrid undulators with two different undulator periods (SXU: 55 mm, HXU: 32 mm). An algebraic FEL tolerance analysis for the undulator lines, including tuning, alignment, and phase correction tolerances has been performed. The methods and results are presented in this paper.

  2. Spectral Compatibility Analysis of the Enhanced Vegetation Indices (EVI) across VIIRS, MODIS, and AVHRR Using EO-1 Hyperion

    NASA Astrophysics Data System (ADS)

    Miura, T.; Turner, J. P.; Huete, A. R.

    2012-12-01

    differences due to the difference in their blue bandpasses, which, however, could be adjusted. Overall, the EVI2 showed higher cross-sensor compatibility than the EVI. However, this appeared attributed to the EVI2 being equally sensitive to residual atmospheric effects across the sensor bandpasses examined in this study. Further analysis is needed to evaluate cost vs. benefit of having a blue band in the EVI equation.

  3. Analysis of expressed sequence tags derived from a compatible Mycosphaerella fijiensis-banana interaction.

    PubMed

    Portal, Orelvis; Izquierdo, Yovanny; De Vleesschauwer, David; Sánchez-Rodríguez, Aminael; Mendoza-Rodríguez, Milady; Acosta-Suárez, Mayra; Ocaña, Bárbara; Jiménez, Elio; Höfte, Monica

    2011-05-01

    Mycosphaerella fijiensis, a hemibiotrophic fungus, is the causal agent of black leaf streak disease, the most serious foliar disease of bananas and plantains. To analyze the compatible interaction of M. fijiensis with Musa spp., a suppression subtractive hybridization (SSH) cDNA library was constructed to identify transcripts induced at late stages of infection in the host and the pathogen. In addition, a full-length cDNA library was created from the same mRNA starting material as the SSH library. The SSH procedure was effective in identifying specific genes predicted to be involved in plant-fungal interactions and new information was obtained mainly about genes and pathways activated in the plant. Several plant genes predicted to be involved in the synthesis of phenylpropanoids and detoxification compounds were identified, as well as pathogenesis-related proteins that could be involved in the plant response against M. fijiensis infection. At late stages of infection, jasmonic acid and ethylene signaling transduction pathways appear to be active, which corresponds with the necrotrophic life style of M. fijiensis. Quantitative PCR experiments revealed that antifungal genes encoding PR proteins and GDSL-like lipase are only transiently induced 30 days post inoculation (dpi), indicating that the fungus is probably actively repressing plant defense. The only fungal gene found was induced 37 dpi and encodes UDP-glucose pyrophosphorylase, an enzyme involved in the biosynthesis of trehalose. Trehalose biosynthesis was probably induced in response to prior activation of plant antifungal genes and may act as an osmoprotectant against membrane damage. PMID:21279642

  4. Materials compatibility.

    SciTech Connect

    Somerday, Brian P.

    2010-04-01

    Objectives are to enable development and implementation of codes and standards for H{sub 2} containment components: (1) Evaluate data on mechanical properties of materials in H{sub 2} gas - Technical Reference on Hydrogen Compatibility of Materials; (2) Generate new benchmark data on high-priority materials - Pressure vessel steels, stainless steels; and (3) Establish procedures for reliable materials testing - Sustained-load cracking, fatigue crack propagation. Summary of this presentation are: (1) Completed measurement of cracking thresholds (K{sub TH}) for Ni-Cr-Mo pressure vessel steels in high-pressure H{sub 2} gas - K{sub TH} measurements required in ASME Article KD-10 (2) Crack arrest test methods appear to yield non-conservative results compared to crack initiation test methods - (a) Proposal to insert crack initiation test methods in Article KD-10 will be presented to ASME Project Team on Hydrogen Tanks, and (b) Crack initiation methods require test apparatus designed for dynamic loading of specimens in H{sub 2} gas; and (3) Demonstrated ability to measure fatigue crack growth of pressure vessel steels in high-pressure H{sub 2} gas - (a) Fatigue crack growth data in H{sub 2} required in ASME Article KD-10, and (b) Test apparatus is one of few in U.S. or abroad for measuring fatigue crack growth in >100 MPa H{sub 2} gas.

  5. Compatibility: drugs and parenteral nutrition.

    PubMed

    Miranda, Talita Muniz Maloni; Ferraresi, Andressa de Abreu

    2016-03-01

    Objective Standardization and systematization of data to provide quick access to compatibility of leading injectable drugs used in hospitals for parenteral nutrition. Methods We selected 55 injectable drugs analyzed individually with two types of parenteral nutrition: 2-in-1 and 3-in-1. The following variables were considered: active ingredient, compatibility of drugs with the parenteral nutrition with or without lipids, and maximum drug concentration after dilution for the drugs compatible with parenteral nutrition. Drugs were classified as compatible, incompatible and untested. Results After analysis, relevant information to the product's compatibility with parental nutrition was summarized in a table. Conclusion Systematization of compatibility data provided quick and easy access, and enabled standardizing pharmacists work. PMID:27074235

  6. Analysis of photosystem II biogenesis in cyanobacteria.

    PubMed

    Heinz, Steffen; Liauw, Pasqual; Nickelsen, Jörg; Nowaczyk, Marc

    2016-03-01

    Photosystem II (PSII), a large multisubunit membrane protein complex found in the thylakoid membranes of cyanobacteria, algae and plants, catalyzes light-driven oxygen evolution from water and reduction of plastoquinone. Biogenesis of PSII requires coordinated assembly of at least 20 protein subunits, as well as incorporation of various organic and inorganic cofactors. The stepwise assembly process is facilitated by numerous protein factors that have been identified in recent years. Further analysis of this process requires the development or refinement of specific methods for the identification of novel assembly factors and, in particular, elucidation of the unique role of each. Here we summarize current knowledge of PSII biogenesis in cyanobacteria, focusing primarily on the impact of methodological advances and innovations. This article is part of a Special Issue entitled Organization and dynamics of bioenergetic systems in bacteria, edited by Conrad Mullineaux. PMID:26592144

  7. FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (UNIX VERSION)

    NASA Technical Reports Server (NTRS)

    Newman, J. C.

    1994-01-01

    Predictions of fatigue crack growth behavior can be made with the Fatigue Crack Growth Structural Analysis (FASTRAN II) computer program. As cyclic loads are applied to a selected crack configuration with an initial crack size, FASTRAN II predicts crack growth as a function of cyclic load history until either a desired crack size is reached or failure occurs. FASTRAN II is based on plasticity-induced crack-closure behavior of cracks in metallic materials and accounts for load-interaction effects, such as retardation and acceleration, under variable-amplitude loading. The closure model is based on the Dugdale model with modifications to allow plastically deformed material to be left along the crack surfaces as the crack grows. Plane stress and plane strain conditions, as well as conditions between these two, can be simulated in FASTRAN II by using a constraint factor on tensile yielding at the crack front to approximately account for three-dimensional stress states. FASTRAN II contains seventeen predefined crack configurations (standard laboratory fatigue crack growth rate specimens and many common crack configurations found in structures); and the user can define one additional crack configuration. The baseline crack growth rate properties (effective stress-intensity factor against crack growth rate) may be given in either equation or tabular form. For three-dimensional crack configurations, such as surface cracks or corner cracks at holes or notches, the fatigue crack growth rate properties may be different in the crack depth and crack length directions. Final failure of the cracked structure can be modelled with fracture toughness properties using either linear-elastic fracture mechanics (brittle materials), a two-parameter fracture criterion (brittle to ductile materials), or plastic collapse (extremely ductile materials). The crack configurations in FASTRAN II can be subjected to either constant-amplitude, variable-amplitude or spectrum loading. The applied

  8. FASTRAN II - FATIGUE CRACK GROWTH STRUCTURAL ANALYSIS (IBM PC VERSION)

    NASA Technical Reports Server (NTRS)

    Newman, J. C.

    1994-01-01

    Predictions of fatigue crack growth behavior can be made with the Fatigue Crack Growth Structural Analysis (FASTRAN II) computer program. As cyclic loads are applied to a selected crack configuration with an initial crack size, FASTRAN II predicts crack growth as a function of cyclic load history until either a desired crack size is reached or failure occurs. FASTRAN II is based on plasticity-induced crack-closure behavior of cracks in metallic materials and accounts for load-interaction effects, such as retardation and acceleration, under variable-amplitude loading. The closure model is based on the Dugdale model with modifications to allow plastically deformed material to be left along the crack surfaces as the crack grows. Plane stress and plane strain conditions, as well as conditions between these two, can be simulated in FASTRAN II by using a constraint factor on tensile yielding at the crack front to approximately account for three-dimensional stress states. FASTRAN II contains seventeen predefined crack configurations (standard laboratory fatigue crack growth rate specimens and many common crack configurations found in structures); and the user can define one additional crack configuration. The baseline crack growth rate properties (effective stress-intensity factor against crack growth rate) may be given in either equation or tabular form. For three-dimensional crack configurations, such as surface cracks or corner cracks at holes or notches, the fatigue crack growth rate properties may be different in the crack depth and crack length directions. Final failure of the cracked structure can be modelled with fracture toughness properties using either linear-elastic fracture mechanics (brittle materials), a two-parameter fracture criterion (brittle to ductile materials), or plastic collapse (extremely ductile materials). The crack configurations in FASTRAN II can be subjected to either constant-amplitude, variable-amplitude or spectrum loading. The applied

  9. Compatibility Conditions of Structural Mechanics

    NASA Technical Reports Server (NTRS)

    Patnaik, Surya N.; Coroneos, Rula M.; Hopkins, Dale A.

    1999-01-01

    The theory of elasticity has camouflaged a deficiency in the compatibility formulation since 1860. In structures the ad hoc compatibility conditions through virtual "cuts" and closing "gaps" are not parallel to the strain formulation in elasticity. This deficiency in the compatibility conditions has prevented the development of a direct stress determination method in structures and in elasticity. We have addressed this deficiency and attempted to unify the theory of compatibility. This work has led to the development of the integrated force method for structures and the completed Beltrami-Michell formulation for elasticity. The improved accuracy observed in the solution of numerical examples by the integrated force method can be attributed to the compliance of the compatibility conditions. Using the compatibility conditions allows mapping of variables and facile movement among different structural analysis formulations. This paper reviews and illustrates the requirement of compatibility in structures and in elasticity. It also describes the generation of the conditions and quantifies the benefits of their use. The traditional analysis methods and available solutions (which have been obtained bypassing the missed conditions) should be verified for compliance of the compatibility conditions.

  10. Shuttle communication and tracking systems signal design and interface compatibility analysis

    NASA Technical Reports Server (NTRS)

    1986-01-01

    Various options for the Dedicated Payload Communication Link (DPCL) were evaluated. Specific subjects addressed include: payload to DPCL power transfer in the proximity of the payload, DPCL antenna pointing considerations, and DPCL transceiver implementations which can be mounted on the deployed antenna boom. Additional analysis of the Space Telescope performance was conducted. The feasibility of using the Global Positioning System (GPS) for attitude determination and control for large spacecraft was examined. The objective of the Shuttle Orbiter Radar Test and Evaluation (SORTE) program was to quantify the Ku-band radar tracking accuracy using White Sands Missile Range (WSMR) radar and optical tracking equipment, with helicopter and balloon targets.

  11. [Socioeconomic cost-effectiveness analysis--occupational rehabilitation between effectiveness and social compatibility].

    PubMed

    Wegner, E

    2001-06-01

    The fundamental question in case of planning projects of the state is which pros and cons are involved in their realization. Public projects take up a lot of social resources which hence are no longer available for other purposes--especially when you look at existing budgetary limits. A decision in favour of one specific project always implies a decision against some other project. A classical method to evaluate public projects is the cost-benefit analysis, which leads a shadowy existence owing to its difficulties in practical application (first and foremost in identifying and quantifying). In this article a possible application for cost-benefit analysis is demonstrated on the example of an institution for initial vocational training of young people with disabilities or at risk of becoming disabled. The main point here is to widen the focus from simply looking at fiscal expenses, revenues and savings towards also taking notice of social, psychological and health orientated facts. In this view it is very consequent to enlarge the "normal" economic balance sheet by drawing up a special social balance sheet which illustrates advantages and disadvantages difficult to measure at a monetary basis. A comprehensive decision basis is thereby achieved considering "both sides of the medal". PMID:11469047

  12. Improved structure, function and compatibility for CellProfiler: modular high-throughput image analysis software

    PubMed Central

    Kamentsky, Lee; Jones, Thouis R.; Fraser, Adam; Bray, Mark-Anthony; Logan, David J.; Madden, Katherine L.; Ljosa, Vebjorn; Rueden, Curtis; Eliceiri, Kevin W.; Carpenter, Anne E.

    2011-01-01

    Summary: There is a strong and growing need in the biology research community for accurate, automated image analysis. Here, we describe CellProfiler 2.0, which has been engineered to meet the needs of its growing user base. It is more robust and user friendly, with new algorithms and features to facilitate high-throughput work. ImageJ plugins can now be run within a CellProfiler pipeline. Availability and Implementation: CellProfiler 2.0 is free and open source, available at http://www.cellprofiler.org under the GPL v. 2 license. It is available as a packaged application for Macintosh OS X and Microsoft Windows and can be compiled for Linux. Contact: anne@broadinstitute.org Supplementary information: Supplementary data are available at Bioinformatics online. PMID:21349861

  13. Classification of Colletotrichum coccodes isolates into vegetative compatibility groups using infrared attenuated total reflectance spectroscopy and multivariate analysis.

    PubMed

    Salman, A; Shufan, E; Tsror, L; Moreh, R; Mordechai, S; Huleihel, M

    2014-07-01

    In this study the potential of infrared (IR) spectroscopy for the classification of Colletotrichum coccodes (C. coccodes) isolates into vegetative compatibility groups (VCGs) was evaluated. Isolates which belong to the same VCG may have similar pathological and physiological traits that differ from those that are not assigned to the same VCG. Early classification of isolates into VCGs is of a great importance for a better understanding of the epidemiology of the disease and improves its control. The main goal of the present study was to classify 14 isolates of C. coccodes into VCGs and differentiate between them, based on their IR absorption spectra as obtained by the FTIR-ATR sampling technique. Advanced statistical and mathematical methods, including Principal Component Analysis (PCA) and Linear Discriminant Analysis (LDA), were applied to the spectra after manipulation. The results show that it is possible to assign the isolates into VCGs with more than 90% success based on the wavenumber low region (1800-800 cm(-1)) and using 15 PCs. However, on the isolate level, the best differentiation results were obtained using PCA (15 PCs) and LDA for the combined regions (2990-2800 cm(-1), 1800-800 cm(-1)), with identification success rates of 87.2%. PMID:24582779

  14. Evaluation of cellular affinity and compatibility to biodegradable polyesters and Type-II collagen-modified scaffolds using immortalized rat chondrocytes.

    PubMed

    Hsu, Shan-Hui; Tsai, Ching-Lin; Tang, Cheng-Ming

    2002-07-01

    Immortalized rat chondrocytes (IRCs) were employed to evaluate the cytocompatibility of different biodegradable polyester scaffolds for chondrocyte seeding and cartilage tissue engineering in vitro due to the limitation of using freshly harvested chondroctyes. Cells were seeded onto the films and the porous substrates as well as into the three-dimensional scaffolds made of the biodegradable polyesters including poly(l-lactide) (PLLA) and two poly(lactide-co-glycolide)s (PLGAs). The materials were characterized by water contact angle, electron spectroscopy for chemical analysis (ESCA), and microscopy. PLGA50/50, one of the PLGAs, had the largest cell numbers at 24 h and 96 h (close to the tissue culture polystyrene control), possibly due to its lower contact angle, higher oxygen/carbon (O/C) atomic ratio, and larger degradation rate. When the surface was further modified by cross-linked Type-II collagen, cell population was significantly enhanced (two- to fourfold). The adhesion and proliferation behavior of IRCs on different materials was parallel to that of rabbit chondrocytes, but was more reproducible in general. IRCs are thus suitable for evaluation of different polymer scaffolds. Despite the favorable cytocompatibility of PLGA50/50, blending with a small portion of PLLA is required for easy fabrication and collagen modification. Scaffolds made of blended materials by freeze-drying procedure with the surface modified by cross-linked Type-II collagen were demonstrated as the ideal templates for chondrocyte seeding in our study. PMID:12081523

  15. Compatibility between mental disorder and mental capacity: analysis of a particular case of group sexual homicide.

    PubMed

    Carabellese, Felice; Vinci, Francesco; Catanesi, Roberto

    2008-11-01

    On the night of August 19, 2000, at the foot of Castel del Monte, an 8-year-old girl was brutally murdered. The perpetrators were identified as five young men who captured their victim and sexually abused her. The policemen found the cadaver by following "Mario," one of the five, who had been discovered lying on the ground, near the castle. Investigation led to demonstrate that the murder was not premeditated. The only desire of the group was to sexually molest the little girl. Mario showed signs of psychiatric pathology and for that he underwent psychiatric evaluation by judicial authorities. Analysis of this case, combined with a criminological and medical-legal perspective led to conclusions very much different from the expectations of Mario's defense attorneys. Mario, a marginal figure and seemingly the least intelligent, played the role of group instigator, both in the initiation of sexually abusing the child, as well as in the elimination of an inconvenient witness. However, the group was able to activate Mario's sadistic fantasies and his sexual perversions, and he ended up in a catalyzing role influencing the behavior of others and realizing what would otherwise remain only fantasies. The circularity of the group allows people like Mario, who are apparently subordinate, to influence the behavior of others. Mario was found to have a mental disorder but it was not sufficient to diminish his personal responsibility related to the crime. In fact, according to Italian judicial code, it is necessary that the motivation for the crime was psychopathological. It was for this reason that, according to Italian law, all of the members of the group were considered to be responsible for the crimes committed and were condemned. PMID:19017073

  16. Run II data analysis on the grid

    SciTech Connect

    Igor Mandrichenko, Igor Terekhov and Frank Wurthwein

    2002-12-02

    In this document, we begin the technical design for the distributed RunII computing for CDF and D0. The present paper defines the three components of the data handling area of Run II computing, namely the Data Handling System, the Storage System and the Application. We outline their functionality and interaction between them. We identify necessary and desirable elements of the interfaces.

  17. Simultaneous determination of Cd(II), Cu(II), Pb(II), and Zn(II) in citrus essential oils by derivative potentiometric stripping analysis.

    PubMed

    La Pera, Lara; Saitta, Marcello; Di Bella, Giuseppa; Dugo, Giacomo

    2003-02-26

    Citrus essential oils are widely used in the food, cosmetics, and pharmaceutical industries, so the determination of heavy metals content is of great importance to guarantee their quality. The present work deals with the quantification of Cd(II), Cu(II), Pb(II), and Zn(II) in different varieties of citrus essential oils, using derivative potentiometric stripping analysis. Two different metals extraction procedures, involving concentrated hydrochloric acid treatment and acid-alcoholic dissolution, are tested on lemon, mandarin, sweet orange, and bergamot essential oils, and they give very similar results. Cd(II), Cu(II), Pb(II), and Zn(II) recovery tests spanned from 95 to 100.50%, providing evidence that metals quantification remained unaffected by the cleanup steps of the two procedures. The repeatability of the hydrochloric acid extraction method, applied on different varieties of essential oils, is >95.00% for Cd(II), Cu(II), Pb(II), and Zn(II), whereas the repeatability of the acid-alcoholic dissolution method is >93.00% for Cu and Cd only in lemon oil. Detection limits obtained for the four analytes, using both procedures, ranged from 0.10 to 0.98 ng g(-)(1) in lemon, mandarin, sweet orange, and bergamot essential oils. PMID:12590445

  18. Pyrosequencing-Based Transcriptome Analysis of the Asian Rice Gall Midge Reveals Differential Response during Compatible and Incompatible Interaction

    PubMed Central

    Sinha, Deepak Kumar; Nagaraju, Javaregowda; Tomar, Archana; Bentur, Jagadish S.; Nair, Suresh

    2012-01-01

    The Asian rice gall midge (Orseolia oryzae) is a major pest responsible for immense loss in rice productivity. Currently, very little knowledge exists with regard to this insect at the molecular level. The present study was initiated with the aim of developing molecular resources as well as identifying alterations at the transcriptome level in the gall midge maggots that are in a compatible (SH) or in an incompatible interaction (RH) with their rice host. Roche 454 pyrosequencing strategy was used to develop both transcriptomics and genomics resources that led to the identification of 79,028 and 85,395 EST sequences from gall midge biotype 4 (GMB4) maggots feeding on a susceptible and resistant rice variety, TN1 (SH) and Suraksha (RH), respectively. Comparative transcriptome analysis of the maggots in SH and RH revealed over-representation of transcripts from proteolysis and protein phosphorylation in maggots from RH. In contrast, over-representation of transcripts for translation, regulation of transcription and transcripts involved in electron transport chain were observed in maggots from SH. This investigation, besides unveiling various mechanisms underlying insect-plant interactions, will also lead to a better understanding of strategies adopted by insects in general, and the Asian rice gall midge in particular, to overcome host defense. PMID:23202939

  19. Multicriteria analysis as a tool to investigate compatibility between conservation and development on Salina Island, Aeolian Archipelago, Italy

    NASA Astrophysics Data System (ADS)

    Bodini, Antonio; Giavelli, Giovanni

    1992-09-01

    Several multicriteria evaluation techniques have been developed since the 1970s. The need to compare different territorial policies has justified their introduction into environmental research. These methods are based on the numerical manipulation of heterogeneous information, which varies in terms of reference scale and type of measure (continuous, ordinal, qualitative, binary, etc.). During recent years, diverse investigations have focused on general conditions on Salina, the “green island” of the Aeolian archipelago. Such studies, within an interdisciplinary project, aimed to explore the possibility of implementing conservation strategies that are compatible with human needs, landscape preservation, and sustainable economic development. Three different evaluation techniques are applied, namely multicriteria weighted concordance and discordance analysis and a qualitative procedure. They are used to compare four alternative plans for the socioeconomic development of Salina Island. These plans lie between extreme alternatives: total protection of natural resources and maximizing economic development based on tourism. The plans are compared to each other on the basis of 14 criteria that reflect the socioenvironmental perception of Salina's inhabitants. The approach used in this research seems particularly fruitful because of its flexibility: it offers decision makers the chance to manage heterogeneous data and information that is not easily quantifiable. Such “soft” information helps to evaluate environmental conditions more precisely, and to make a less damaging choice among alternative development plans.

  20. Synthesis, spectroscopic characterization, thermal analysis and electrical conductivity studies of Mg(II), Ca(II), Sr(II) and Ba(II) vitamin B2 complexes

    NASA Astrophysics Data System (ADS)

    Refat, Moamen S.; Moussa, Mohamed A. A.; Mohamed, Soha F.

    2011-05-01

    Riboflavin (RF) complexes of Mg(II), Ca(II), Sr(II) and Ba(II) were successfully synthesized. Structures of metal complexes obtained were confirmed and characterized by elemental analysis, molar conductance, and infrared spectra. DC electrical conductivity measurements indicated that the alkaline earth metal (II) complexes of RF ligand are non-electrolytes. Elemental analysis of chelates suggest that the metal(II) ligand ratio is 1:2 with structure formula as [M(RF) 2( X) 2]· nH 2O. Infrared assignments clearly show that RF ligand coordinated as a bidentate feature through azomethine nitrogen of pyrazine ring and C dbnd O of pyrimidine-2,4-dione. Thermal analyses of Mg(II), Ca(II), Sr(II) and Ba(II) complexes were investigated using (TG/DSC) under atmospheric nitrogen between 30 and 800 °C. The surface morphology of the complexes was studied by SEM. The electrical conductivities of RF and its metal complexes were also measured with DC electrical conductivity in the temperature range from room to 483 K.

  1. Compatibility of segmented thermoelectric generators

    NASA Technical Reports Server (NTRS)

    Snyder, J.; Ursell, T.

    2002-01-01

    It is well known that power generation efficiency improves when materials with appropriate properties are combined either in a cascaded or segmented fashion across a temperature gradient. Past methods for determining materials used in segmentation weremainly concerned with materials that have the highest figure of merit in the temperature range. However, the example of SiGe segmented with Bi2Te3 and/or various skutterudites shows a marked decline in device efficiency even though SiGe has the highest figure of merit in the temperature range. The origin of the incompatibility of SiGe with other thermoelectric materials leads to a general definition of compatibility and intrinsic efficiency. The compatibility factor derived as = (Jl+zr - 1) a is a function of only intrinsic material properties and temperature, which is represented by a ratio of current to conduction heat. For maximum efficiency the compatibility factor should not change with temperature both within a single material, and in the segmented leg as a whole. This leads to a measure of compatibility not only between segments, but also within a segment. General temperature trends show that materials are more self compatible at higher temperatures, and segmentation is more difficult across a larger -T. The compatibility factor can be used as a quantitative guide for deciding whether a material is better suited for segmentation orcascading. Analysis of compatibility factors and intrinsic efficiency for optimal segmentation are discussed, with intent to predict optimal material properties, temperature interfaces, and/or currentheat ratios.

  2. Non-targeted evaluation of selectivity of water-compatible class selective adsorbents for the analysis of steroids in wastewater.

    PubMed

    Kopperi, Matias; Riekkola, Marja-Liisa

    2016-05-12

    Selective adsorbents for solid-phase extraction are needed to meet the low concentration requirements of new environmental quality standard directives, especially for the analysis of estrogens in wastewater. In this work, bulk polymerization procedures were first optimized for the synthesis of non-imprinted polymers (NIP) with low non-specific adsorption of nonpolar compounds in aqueous environments. Water-compatible molecularly imprinted polymers (MIP) were then synthetized by increasing the selectivity of the polymer towards steroids with a testosterone template (average imprinting factor > 10). In addition, the affinity of synthetized entrapped β-cyclodextrin-epichlorohydrin polymers (ECD) towards steroids was clarified. The polymers were applied to the extraction of spiked wastewater effluent samples and their performance compared to commercially available adsorbents. The selectivity of the studied adsorbents was evaluated utilizing liquid chromatography ‒ mass spectrometry as well as comprehensive two-dimensional gas chromatography ‒ time-of-flight mass spectrometry. Affinity between adsorbents and steroids as well as matrix removal potential were measured with targeted methodologies, and two novel non-targeted methodologies were proposed to quantitatively measure adsorbent selectivity by utilizing chemometrics. Semi-quantitative selectivity was measured from the ratio of peak areas between steroidal and other compounds. Semi-qualitative selectivity was calculated from the ratio between the number of tentatively identified steroidal and other compounds. The synthetized polymers provided good matrix removal potential (ion suppression 15-30%) and semi-qualitative selectivity (∼4 units) compared to the commercial adsorbents (ion suppression 45-80%, selectivity < 3 units). Simple non-targeted approaches provided a novel method of quantifying the selectivity of extraction. PMID:27114222

  3. Transcriptomic and proteomic analysis of a compatible tomato-aphid interaction reveals a predominant salicylic acid-dependent plant response

    PubMed Central

    2013-01-01

    Background Aphids are among the most destructive pests in temperate climates, causing significant damage on several crops including tomato. We carried out a transcriptomic and proteomic study to get insights into the molecular mechanisms and dynamics of the tomato response to the Macrosyphum euphorbiae aphid. Results The time course analysis of aphid infestation indicated a complex, dynamic pattern of gene expression. Several biological functions were affected and genes related to the stress and defence response were the most represented. The Gene Ontology categories of the differentially expressed genes (899) and identified proteins (57) indicated that the tomato response is characterized by an increased oxidative stress accompanied by the production of proteins involved in the detoxification of oxygen radicals. Aphids elicit a defense reaction based on the cross-communication of different hormone-related signaling pathways such as those related to the salicylic acid (SA), jasmonic acid (JA), ethylene and brassinosteroids. Among them, the SA-signaling pathway and stress-responsive SA-dependent genes play a dominant role. Furthermore, tomato response is characterized by a reduced accumulation of photosynthetic proteins and a modification of the expression of various cell wall related genes. Conclusions Our work allowed a more comprehensive understanding of the signaling events and the defense dynamics of the tomato response to aphids in a compatible interaction and, based on experimental data, a model of the tomato–aphid molecular interaction was proposed. Considering the rapid advancement of tomato genomics, this information will be important for the development of new protection strategies. PMID:23895395

  4. A rapid compatibility analysis of potential offshore sand sources for beaches of the Santa Barbara Littoral Cell

    USGS Publications Warehouse

    Mustain, N.; Griggs, G.; Barnard, P.L.

    2007-01-01

    The beaches of the Santa Barbara Littoral Cell, which are narrow as a result of either natural and/or anthropogenic factors, may benefit from nourishment. Sand compatibility is fundamental to beach nourishment success and grain size is the parameter often used to evaluate equivalence. Only after understanding which sand sizes naturally compose beaches in a specific cell, especially the smallest size that remains on the beach, can the potential compatibility of source areas, such as offshore borrow sites, be accurately assessed. This study examines sediments on the beach and in the nearshore (5-20m depth) for the entire Santa Barbara Littoral Cell east of Point Conception. A digital bed sediment camera, the Eyeball??, and spatial autocorrelation technique were used to determine sediment grain size. Here we report on whether nearshore sediments are comparable and compatible with beach sands of the Santa Barbara Littoral Cell. ?? 2007 ASCE.

  5. Analysis of the compatibility between the Maxwell-Boltzmann distribution and the Rayleigh-Jeans spectrum for classical systems

    NASA Astrophysics Data System (ADS)

    Blanco, R.; Pesquera, L.

    1986-01-01

    We analyze in detail the validity of the compatibility between the Maxwell-Boltzmann (MB) distribution and the Rayleigh-Jeans (RJ) spectrum obtained in recent works by the authors for classical relativistic systems. We show that the MB distribution and the RJ spectrum are not compatible if we do not remove high enough frequencies. By analyzing the applicability of the approximation methods used in previous works to obtain the MB distribution from the RJ spectrum, we conclude that these methods are valid only if we introduce a high-frequency cutoff in the RJ spectrum. A short discussion is made on the meaning of this cutoff.

  6. Compatibility between Text Mining and Qualitative Research in the Perspectives of Grounded Theory, Content Analysis, and Reliability

    ERIC Educational Resources Information Center

    Yu, Chong Ho; Jannasch-Pennell, Angel; DiGangi, Samuel

    2011-01-01

    The objective of this article is to illustrate that text mining and qualitative research are epistemologically compatible. First, like many qualitative research approaches, such as grounded theory, text mining encourages open-mindedness and discourages preconceptions. Contrary to the popular belief that text mining is a linear and fully automated…

  7. Content Analysis of "School Psychology International", 1990-2011: An Analysis of Trends and Compatibility with the NASP Practice Model

    ERIC Educational Resources Information Center

    Little, Steven G.; Akin-Little, Angeleque; Lloyd, Keryn

    2011-01-01

    Formal analysis of research publications serves as one indicator of the current status of a profession or a journal. Content analyses provide both practitioners and academicians with information on the status of research in the profession. These types of analyses can also provide information on the concordance between published research and what…

  8. ANALYSIS OF NSLS-II TOUSCHEK LIFETIME

    SciTech Connect

    Choi, J.; Kramer, S.L.

    2011-03-28

    As scrapers are adopted for the loss control of NSLS-II storage ring, Touschek lifetime estimations for various cases are required to assure the stable operation. However, to estimate the Touschek lifetime, momentum apertures should be measured all along the ring and, if we want to estimate the lifetime in various situations, it can take extremely long time. Thus, rather than simulating for each case, a semi-analytic methods with the interpolations are used for the measurements of the momentum apertures. In this paper, we described the methods and showed the results. Having enough Touschek lifetime is important for synchrotron light source for the users to perform experiments with stable beams. In NSLS-II, the scrapers will be installed for the loss control. Especially, the horizontal scrapers will be installed where the dispersions are maximum. Therefore, we need to find the proper scraper gap values which do not reduce the lifetime too much for the stable beam operation. To estimate reliable Touschek lifetime, we should measure the momentum apertures at many positions along the ring. For the rough estimation of the Touschek lifetime, the RF momentum acceptance can be used and for a more detailed estimation, the linear approximation of synchrotron oscillation can be used. However, for the strong focussing synchrotrons, like NSLS-II, the linear approximation is not enough to obtain the reliable momentum apertures, and, in general, particle tracking simulations are used. However, for NSLS-II case, we need to track the particle about 400 turns at each point to make it a full synchrotron oscillation period and to obtain the reliable Touschek lifetime we need measure the momentum apertures at several hundred positions at least. Therefore, it can take quite a long time if we want to have the reasonable resolution for the measurements. Furthermore, at the simulation, if we want to measure the aperture inside a element, we should divide the element and this will make the

  9. Photocatalytic formulations for protein fibers: experimental analysis of the effect of preparation on compatibility and photocatalytic activities.

    PubMed

    Tung, Wing Sze; Daoud, Walid A

    2008-10-01

    In this article, we report an optimization study of a photocatalytic self-cleaning sol-gel formulation. In particular we studied the effect of formulation preparation time on the formation of anatase titanium dioxide sol and its compatibility to protein keratin-type wool fibers. The sols were formed by a low temperature sol-gel process. The nucleated anatase was characterized by UV-vis transmission, particle size distribution, X-ray diffraction, and transmission electron microscopy. The compatibility between the formulations and wool fibers is evaluated by field-emission scanning electron microscopy, UV transmission, and mechanical properties. The photocatalytic self-cleaning activity of coated fibers and its reproducibility are also discussed. PMID:18691723

  10. Preparation and Spectrophotometric Analysis of Hexaamminenickel(II) Chloride.

    ERIC Educational Resources Information Center

    Wieder, Grace M.

    1986-01-01

    Describes an experiment developed at Brooklyn College (New York) in which the preparation and ammonia analysis of an amminenickel(II) chloride is extended to include a spectrophotometric analysis for nickel. Discusses the materials needed and the procedure for the experiment which takes nine hours of laboratory work. (TW)

  11. Orbit Response Matrix Analysis Applied at PEP-II

    SciTech Connect

    Steier, C.; Wolski, A.; Ecklund, S.; Safranek, J.A.; Tenenbaum, P.; Terebilo, A.; Turner, J.L.; Yocky, G.; /SLAC

    2005-05-17

    The analysis of orbit response matrices has been used very successfully to measure and correct the gradient and skew gradient distribution in many accelerators. It allows determination of an accurately calibrated model of the coupled machine lattice, which then can be used to calculate the corrections necessary to improve coupling, dynamic aperture and ultimately luminosity. At PEP-II, the Matlab version of LOCO has been used to analyze coupled response matrices for both the LER and the HER. The large number of elements in PEP-II and the very complicated interaction region present unique challenges to the data analysis. All necessary tools to make the analysis method useable at PEP-II have been implemented and LOCO can now be used as a routine tool for lattice diagnostic.

  12. Multiwell experiment: reservoir modeling analysis, Volume II

    SciTech Connect

    Horton, A.I.

    1985-05-01

    This report updates an ongoing analysis by reservoir modelers at the Morgantown Energy Technology Center (METC) of well test data from the Department of Energy's Multiwell Experiment (MWX). Results of previous efforts were presented in a recent METC Technical Note (Horton 1985). Results included in this report pertain to the poststimulation well tests of Zones 3 and 4 of the Paludal Sandstone Interval and the prestimulation well tests of the Red and Yellow Zones of the Coastal Sandstone Interval. The following results were obtained by using a reservoir model and history matching procedures: (1) Post-minifracture analysis indicated that the minifracture stimulation of the Paludal Interval did not produce an induced fracture, and extreme formation damage did occur, since a 65% permeability reduction around the wellbore was estimated. The design for this minifracture was from 200 to 300 feet on each side of the wellbore; (2) Post full-scale stimulation analysis for the Paludal Interval also showed that extreme formation damage occurred during the stimulation as indicated by a 75% permeability reduction 20 feet on each side of the induced fracture. Also, an induced fracture half-length of 100 feet was determined to have occurred, as compared to a designed fracture half-length of 500 to 600 feet; and (3) Analysis of prestimulation well test data from the Coastal Interval agreed with previous well-to-well interference tests that showed extreme permeability anisotropy was not a factor for this zone. This lack of permeability anisotropy was also verified by a nitrogen injection test performed on the Coastal Red and Yellow Zones. 8 refs., 7 figs., 2 tabs.

  13. On Software Compatibility.

    ERIC Educational Resources Information Center

    Ershov, Andrei P.

    The problem of compatibility of software hampers the development of computer application. One solution lies in standardization of languages, terms, peripherais, operating systems and computer characteristics. (AB)

  14. Vibrational solvatochromism and electrochromism. II. Multipole analysis.

    PubMed

    Lee, Hochan; Choi, Jun-Ho; Cho, Minhaeng

    2012-09-21

    Small infrared probe molecules have been widely used to study local electrostatic environment in solutions and proteins. Using a variety of time- and frequency-resolved vibrational spectroscopic methods, one can accurately measure the solvation-induced vibrational frequency shifts and the timescales and amplitudes of frequency fluctuations of such IR probes. Since the corresponding frequency shifts are directly related to the local electric field and its spatial derivatives of the surrounding solvent molecules or amino acids in proteins, one can extract information on local electric field around an IR probe directly from the vibrational spectroscopic results. Here, we show that, carrying out a multipole analysis of the solvatochromic frequency shift, the solvatochromic dipole contribution to the frequency shift is not always the dominant factor. In the cases of the nitrile-, thiocyanato-, and azido-derivatized molecules, the solvatochromic quadrupole contributions to the corresponding stretch mode frequency shifts are particularly large and often comparable to the solvatochromic dipole contributions. Noting that the higher multipole moment-solvent electric field interactions are short range effects in comparison to the dipole interaction, the H-bonding interaction-induced vibrational frequency shift can be caused by such short-range multipole-field interaction effects. We anticipate that the present multipole analysis method specifically developed to describe the solvatochromic vibrational frequency shifts will be useful to understand the intermolecular interaction-induced vibrational property changes and to find out a relationship between vibrational solvatochromism and electrochromism of IR probes in condensed phases. PMID:22998262

  15. Vibrational solvatochromism and electrochromism. II. Multipole analysis

    NASA Astrophysics Data System (ADS)

    Lee, Hochan; Choi, Jun-Ho; Cho, Minhaeng

    2012-09-01

    Small infrared probe molecules have been widely used to study local electrostatic environment in solutions and proteins. Using a variety of time- and frequency-resolved vibrational spectroscopic methods, one can accurately measure the solvation-induced vibrational frequency shifts and the timescales and amplitudes of frequency fluctuations of such IR probes. Since the corresponding frequency shifts are directly related to the local electric field and its spatial derivatives of the surrounding solvent molecules or amino acids in proteins, one can extract information on local electric field around an IR probe directly from the vibrational spectroscopic results. Here, we show that, carrying out a multipole analysis of the solvatochromic frequency shift, the solvatochromic dipole contribution to the frequency shift is not always the dominant factor. In the cases of the nitrile-, thiocyanato-, and azido-derivatized molecules, the solvatochromic quadrupole contributions to the corresponding stretch mode frequency shifts are particularly large and often comparable to the solvatochromic dipole contributions. Noting that the higher multipole moment-solvent electric field interactions are short range effects in comparison to the dipole interaction, the H-bonding interaction-induced vibrational frequency shift can be caused by such short-range multipole-field interaction effects. We anticipate that the present multipole analysis method specifically developed to describe the solvatochromic vibrational frequency shifts will be useful to understand the intermolecular interaction-induced vibrational property changes and to find out a relationship between vibrational solvatochromism and electrochromism of IR probes in condensed phases.

  16. On intracluster Faraday rotation. II - Statistical analysis

    NASA Technical Reports Server (NTRS)

    Lawler, J. M.; Dennison, B.

    1982-01-01

    The comparison of a reliable sample of radio source Faraday rotation measurements seen through rich clusters of galaxies, with sources seen through the outer parts of clusters and therefore having little intracluster Faraday rotation, indicates that the distribution of rotation in the former population is broadened, but only at the 80% level of statistical confidence. Employing a physical model for the intracluster medium in which the square root of magnetic field strength/turbulent cell per gas core radius number ratio equals approximately 0.07 microgauss, a Monte Carlo simulation is able to reproduce the observed broadening. An upper-limit analysis figure of less than 0.20 microgauss for the field strength/turbulent cell ratio, combined with lower limits on field strength imposed by limitations on the Compton-scattered flux, shows that intracluster magnetic fields must be tangled on scales greater than about 20 kpc.

  17. Decomposition of Copper (II) Sulfate Pentahydrate: A Sequential Gravimetric Analysis.

    ERIC Educational Resources Information Center

    Harris, Arlo D.; Kalbus, Lee H.

    1979-01-01

    Describes an improved experiment of the thermal dehydration of copper (II) sulfate pentahydrate. The improvements described here are control of the temperature environment and a quantitative study of the decomposition reaction to a thermally stable oxide. Data will suffice to show sequential gravimetric analysis. (Author/SA)

  18. Intra-sensor Spectral Compatibility Analysis of the Enhanced Vegetation Index for Moderate Resolution Imagers Using Hyperion

    NASA Astrophysics Data System (ADS)

    Miura, T.; Obata, K.; Huete, A. R.

    2013-12-01

    Spectral vegetation indices (VIs) are one of the more important satellite products for monitoring and characterizing seasonal dynamics and interannual variability of terrestrial vegetation in regional to global scales. The enhanced vegetation index (EVI), designed for the National Aeronautics and Space Administration (NASA) Earth Observing System (EOS) Moderate Resolution Imaging Spectroradiometer (MODIS) sensors, has been shown to effectively characterize global vegetation states and ecosystem processes, and encompass the range of biophysical/biochemical information in manners to complement the conventional, normalized difference vegetation index (NDVI). Because the EVI is limited to sensor systems designed with a blue band, a 2-band EVI, without a blue band, was recently developed (referred to as the EVI2), which has the best similarity with the 3-band EVI for the MODIS sensors, particularly when residual atmospheric effects are insignificant and data quality is good. In this study, we evaluated intra-sensor spectral compatibility between the EVI and EVI2 and their sensitivities to aerosol contaminations for select moderate resolution imaging sensors, including Visible/Infrared Imager/Radiometer Suite (VIIRS), MODIS, Second Generation Global Imager (S-GLI), and SPOT-4 VEGETATION, and for Landsat-7 Enhanced Thematic Mapper Plus (ETM+), using a global set of Earth Observing One (EO-1) Hyperion hyperspectral data. Hyperion scenes were spectrally aggregated into red, near-infrared (NIR), and blue bandpasses of the five sensors and spatially aggregated into 1 km resolution pixels. Two atmospheric correction scenarios were also applied to examine the impact of the atmosphere on intra-sensor EVI/EVI2 compatibility: (1) Rayleigh/ozone/water vapor (ROW)-corrected and (2) total-atmosphere-corrected 'top-of-canopy (TOC)' reflectances. The EVI of all the five sensor bandpasses exhibited great resistance to atmospheric aerosol contaminations. The EVI2 of every sensor was, on

  19. Analysis of Infrared Fe II Lines in NGC 4151

    NASA Astrophysics Data System (ADS)

    Thompson, Rodger I.

    1993-12-01

    Analysis of the infrared Fe II line strengths in NGC 4151 indicates that the electron density is 3.8 < log(Ne) < 4.25 and the electron temperature is 8000 < Te < 10,000 K in the narrow line emission region. The analysis utilizes the new collision strengths calculate by Pradhan and Zhang (1993, Ap.J. Letters, 409, L77) for the infrared lines. The line strengths are taken from new spectra between 0.88 and 2.5 microns with the GRIS spectrometer and from earlier work of Osterbrock, Shaw, and Veilleux (1990 Ap.J. 352, 561). The infrared Fe II lines have the advantage of critical densities in the range of log(Ne) 5, a large separation between lines, and greatly reduced extinction. The new infrared spectrum has the additional advantage of a consistent spectrum in time, aperture, and resolution over a large number of lines. For a typical AGN iron to hydrogen ratio the ratio of Fe II emission to Paschen Beta indicates that approximately 10% of the iron in NGC 4151 is in the form of Fe II. Comparision with typical H II region results show that significant grain destruction has occurred in the emission region.

  20. Theoretical analysis of compatibility of several reinforcement materials with NiAl and FeAl matrices

    NASA Technical Reports Server (NTRS)

    Misra, Ajay K.

    1989-01-01

    Several potential reinforcement materials were assessed for their chemical, coefficient of thermal expansion (CTE), and mechanical compatibility with the intermetallic matrices based on NiAl and FeAl. Among the ceramic reinforcement materials, Al2O3, TiC, and TiB2, appear to be the optimum choices for NiAl and FeAl matrices. However, the problem of CTE mismatch with the matrix needs to be solved for these three reinforcement materials. Beryllium-rich intermetallic compounds can be considered as potential reinforcement materials provided suitable reaction barrier coatings can be developed for these. Based on preliminary thermodynamic calculations, Sc2O3 and TiC appear to be suitable as reaction barrier coatings for the beryllides. Several reaction barrier coatings are also suggested for the currently available SiC fibers.

  1. Analysis of basic compounds by supercritical fluid chromatography: attempts to improve peak shape and maintain mass spectrometry compatibility.

    PubMed

    Grand-Guillaume Perrenoud, Alexandre; Boccard, Julien; Veuthey, Jean-Luc; Guillarme, Davy

    2012-11-01

    While neutral and acidic compounds are well separated by supercritical fluid chromatography (SFC), basic analytes are more challenging to separate and often problems occur with their peak shapes. Two different methods were explored in the present paper to reduce these problems and maintain compatibility with mass spectrometry (MS). Five different, commercially available 2-ethylpyridine (2-EP) stationary phases were tested without a mobile phase additive using 92 pharmaceutical compounds with basic properties. The kinetic performances of the 5 columns were nearly identical, but the peak shapes of the basic drugs were strongly affected by the stationary phase. The PrincetonSFC 2-EP and Zymor Pegasus 2-EP phases clearly outperformed the other stationary phases, with 77% and 69% of the compounds having Gaussian peaks (and asymmetries between 0.8 and 1.4), respectively. Comparatively, the Waters Viridis Silica 2-EP, Waters Viridis BEH 2-EP and ES industries GreenSep 2-EP phases provided only 52%, 44% and 22% of the compounds with Gaussian peaks, respectively. These differences were attributed to the significant dissimilarities in their silica matrix properties. An alternative strategy was also performed with a hybrid silica stationary phase, Viridis BEH, using 20mM ammonium hydroxide in the mobile phase, which was a mixture of CO(2) and MeOH. With these conditions, 81% of the peaks observed for the basic analytes were Gaussian; however, this value dropped to 17% and 10% in the absence of additive and in the presence of 20mM formic acid, respectively. Finally, the use of a hybrid bare silica stationary phase in the presence of 20mM ammonium hydroxide is quite an interesting solution as this system is compatible with both ultra high performance SFC (UHPSFC) columns packed with sub-2 μm particles and with MS detection. The overall applicability of this system was demonstrated with various mixtures of basic drugs. PMID:22999421

  2. Integrated data analysis at TJ-II: The density profile

    SciTech Connect

    Milligen, B. Ph. van; Estrada, T.; Ascasibar, E.; Tafalla, D.; Lopez-Bruna, D.; Fraguas, A. Lopez; Jimenez, J. A.; Garcia-Cortes, I.; Dinklage, A.; Fischer, R.

    2011-07-15

    An integrated data analysis system based on Bayesian inference has been developed for the TJ-II stellarator. It reconstructs the electron density profile at a single time point, using data from interferometry, reflectometry, Thomson scattering, and the Helium beam, while providing a detailed error analysis. In this work, we present a novel analysis of the ambiguity inherent in profile reconstruction from reflectometry and show how the integrated data analysis approach elegantly resolves it. Several examples of the application of the technique are provided, in both low-density discharges with and without electrode biasing, and in high-density discharges with an (L-H) confinement transition.

  3. Top-Off Safety Analysis for NSLS-II

    SciTech Connect

    Li,Y.; Casey, B.; Heese, R.; Hseuh, H.; Job, O.; Krinsky, S.; Parker, B.; Shaftan, T.; Sharma, S.

    2009-05-04

    Top-off injection will be adopted in NSLS-II. To ensure no injected beam can pass into experimental beamlines with open photon shutters during top-off injection, simulation studies for possible machine fault scenarios are required. We compare two available simulation methods, backward (H. Nishimura-LBL) and forward tracking (A. Terebilo-SLAC). We also discuss the tracking settings, fault scenarios, apertures and interlocks considered in the analysis.

  4. An Interspecific Backcross of Lycopersicon Esculentum X L. Hirsutum: Linkage Analysis and a Qtl Study of Sexual Compatibility Factors and Floral Traits

    PubMed Central

    Bernacchi, D.; Tanksley, S. D.

    1997-01-01

    A BC(1) population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility locus, S, on chromosome 1 harbored the only QTL for self-incompatibility indicating that the transition to self-compatibility in the lineage leading to the cultivated tomato was primarily the result of mutations at the S locus. Moreover, the major QTL controlling unilateral incongruity also mapped to the S locus, supporting the hypothesis that self-incompatibility and unilateral incongruity are not independent mechanisms. The mating behavior of near-isogenic lines carrying the L. hirsutum allele for the S locus on chromosome 1 in an otherwise L. esculentum background support these conclusions. The S locus region of chromosome 1 also harbors most major QTL for several floral traits important to pollination biology (e.g., number and size of flowers), suggesting a gene complex controlling both genetic and morphological mechanisms of reproduction control. Similar associations in other flowering plants suggest that such complex may have been conserved since early periods of plant evolution or else reflect a convergent evolutionary process. PMID:9335620

  5. An interspecific backcross of Lycopersicon esculentum x L. hirsutum: linkage analysis and a QTL study of sexual compatibility factors and floral traits.

    PubMed

    Bernacchi, D; Tanksley, S D

    1997-10-01

    A BC1 population of the self-compatible tomato Lycopersicon esculentum and its wild self-incompatible relative L. hirsutum f. typicum was used for restriction fragment length polymorphism linkage analysis and quantitative trait loci (QTL) mapping of reproductive behavior and floral traits. The self-incompatibility locus, S, on chromosome 1 harbored the only QTL for self-incompatibility indicating that the transition to self-compatibility in the lineage leading to the cultivated tomato was primarily the result of mutations at the S locus. Moreover, the major QTL controlling unilateral incongruity also mapped to the S locus, supporting the hypothesis that self-incompatibility and unilateral incongruity are not independent mechanisms. The mating behavior of near-isogenic lines carrying the L. hirsutum allele for the S locus on chromosome 1 in an otherwise L. esculentum background support these conclusions. The S locus region of chromosome 1 also harbors most major QTL for several floral traits important to pollination biology (e.g., number and size of flowers), suggesting a gene complex controlling both genetic and morphological mechanisms of reproduction control. Similar associations in other flowering plants suggest that such complex may have been conserved since early periods of plant evolution or else reflect a convergent evolutionary process. PMID:9335620

  6. Transvaginal Surgical Management of Cesarean Scar Pregnancy II (CSP-II): An Analysis of 25 Cases

    PubMed Central

    Zhang, Hui; Shi, Junrong; Yang, Yong’An; Liang, Yijuan; Gao, Xinping; Wang, Jing; Liu, Hui; Wu, Bingge; Zhao, Jinhui

    2015-01-01

    Background The aim of this study was to investigate the feasibility and clinical value of transvaginal surgical treatment for cesarean scar pregnancy (CSP-II). Material/Methods This study was a retrospective analysis of 25 CSP-II patients who received transvaginal surgical treatments. These patients were admitted in our hospital between January 2010 and June 2012. Results All surgical treatments were successful without overt complications. The average operation time was 61.5 minutes, the average intraoperative blood loss was 60.5 ml, the average hospital stay was 9.4 days and the average time that blood β-human chorionic gonadotropin (β-HCG) returned to normal range was 15 days. In all 25 patients, the cesarean scar mass located at the anterior wall of the lower uterine segment disappeared by B-ultrasound examination within 1 or 2 weeks after surgery. Postoperatively, the normal menstrual period started again with an average time of 28.9 days. No menstruation-related abnormalities, such as menstrual dripping or an abnormal amount of blood, were reported after surgery. Conclusions Transvaginal surgery for CSP-II is a novel surgical approach. It has several advantages, including a thorough one-time treatment lesion clearance, short operation time, minimized trauma, minimal intraoperative blood loss, quick reduction of blood β-HCG, and rapid menstruation recovery. It is a simple and feasible surgical approach of great clinical value and few treatment-related complications. PMID:26520674

  7. Urban Integrated Industrial Cogeneration Systems Analysis. Phase II final report

    SciTech Connect

    Not Available

    1984-01-01

    Through the Urban Integrated Industrial Cogeneration Systems Analysis (UIICSA), the City of Chicago embarked upon an ambitious effort to identify the measure the overall industrial cogeneration market in the city and to evaluate in detail the most promising market opportunities. This report discusses the background of the work completed during Phase II of the UIICSA and presents the results of economic feasibility studies conducted for three potential cogeneration sites in Chicago. Phase II focused on the feasibility of cogeneration at the three most promising sites: the Stockyards and Calumet industrial areas, and the Ford City commercial/industrial complex. Each feasibility case study considered the energy load requirements of the existing facilities at the site and the potential for attracting and serving new growth in the area. Alternative fuels and technologies, and ownership and financing options were also incorporated into the case studies. Finally, site specific considerations such as development incentives, zoning and building code restrictions and environmental requirements were investigated.

  8. Texture Analysis for Classification of Risat-Ii Images

    NASA Astrophysics Data System (ADS)

    Chakraborty, D.; Thakur, S.; Jeyaram, A.; Krishna Murthy, Y. V. N.; Dadhwal, V. K.

    2012-08-01

    RISAT-II or Radar Imaging satellite - II is a microwave-imaging satellite lunched by ISRO to take images of the earth during day and night as well as all weather condition. This satellite enhances the ISRO's capability for disaster management application together with forestry, agricultural, urban and oceanographic applications. The conventional pixel based classification technique cannot classify these type of images since it do not take into account the texture information of the image. This paper presents a method to classify the high-resolution RISAT-II microwave images based on texture analysis. It suppress the speckle noise from the microwave image before analysis the texture of the image since speckle is essentially a form of noise, which degrades the quality of an image; make interpretation (visual or digital) more difficult. A local adaptive median filter is developed that uses local statistics to detect the speckle noise of microwave image and to replace it with a local median value. Local Binary Pattern (LBP) operator is proposed to measure the texture around each pixel of the speckle suppressed microwave image. It considers a series of circles (2D) centered on the pixel with incremental radius values and the intersected pixels on the perimeter of the circles of radius r (where r = 1, 3 and 5) are used for measuring the LBP of the center pixel. The significance of LBP is that it measure the texture around each pixel of the image and computationally simple. ISODATA method is used to cluster the transformed LBP image. The proposed method adequately classifies RISAT-II X band microwave images without human intervention.

  9. A METHOD FOR DETERMINING THE COMPATIBILITY OF HAZARDOUS WASTES

    EPA Science Inventory

    This report describes a method for determining the compatibility of the binary combinations of hazardous wastes. The method consists of two main parts, namely: (1) the step-by-step compatibility analysis procedures, and (2) the hazardous wastes compatibility chart. The key elemen...

  10. THE SPECTRUM AND TERM ANALYSIS OF V II

    SciTech Connect

    Thorne, A. P.; Pickering, J. C.; Semeniuk, J. I.

    2013-07-15

    The spectrum and extended term analysis of V II are presented. Fourier transform spectrometry was used to record high resolution spectra of singly ionized vanadium in the region 1492-5800 A (67020-17260 cm{sup -1}) with vanadium-neon and vanadium-argon hollow cathode lamps as sources. The wavenumber uncertainty for the center of gravity of the strongest lines is typically 0.002 cm{sup -1}, an improvement of an order of magnitude over previous measurements. Most of the lines exhibit partly resolved hyperfine structure. The V II energy levels in the 1985 compilation of Sugar and Corliss have been confirmed and revised, with the exception of the high-lying 4f levels and eight of the lower levels. Thirty-nine of the additional eighty-five high levels published by Iglesias et al. have also been confirmed and revised, and three of their missing levels have been found. The energy uncertainty of the revised levels has been reduced by about an order of magnitude. In total, 176 even levels and 233 odd levels are presented. Wavenumbers and classifications are given for 1242 V II lines.

  11. Space processing applications payload equipment study. Volume 2B: Payload interface analysis (power/thermal/electromagnetic compatibility)

    NASA Technical Reports Server (NTRS)

    Hammel, R. L. (Editor); Smith, A. G. (Editor)

    1974-01-01

    As a part of the task of performing preliminary engineering analysis of modular payload subelement/host vehicle interfaces, a subsystem interface analysis was performed to establish the integrity of the modular approach to the equipment design and integration. Salient areas that were selected for analysis were power and power conditioning, heat rejection and electromagnetic capability (EMC). The equipment and load profiles for twelve representative experiments were identified. Two of the twelve experiments were chosen as being representative of the group and have been described in greater detail to illustrate the evaluations used in the analysis. The shuttle orbiter will provide electrical power from its three fuel cells in support of the orbiter and the Spacelab operations. One of the three shuttle orbiter fuel cells will be dedicated to the Spacelab electrical power requirements during normal shuttle operation. This power supplies the Spacelab subsystems and the excess will be available to the payload. The current Spacelab sybsystem requirements result in a payload allocation of 4.0 to 4.8 kW average (24 hour/day) and 9.0 kW peak for 15 minutes.

  12. Chemical compatibility of cartridge materials

    NASA Technical Reports Server (NTRS)

    Wilcox, Roy C.; Zee, R. H.

    1991-01-01

    This twelve month progress report deals with the chemical compatibility of semiconductor crystals grown in zero gravity. Specifically, it studies the chemical compatibility between TZM, a molybdenum alloy containing titanium and zirconium, and WC 103, a titanium alloy containing Niobium and Hafnium, and Gallium arsenide (GaAs) and Cadmium Zinc Tellurite (CdZnTe). Due to the health hazards involved, three approaches were used to study the chemical compatibility between the semiconductor and cartridge materials: reaction retort, thermogravimetric analysis, and bulk cylindrical cartridge containers. A scanning electron microscope with an energy dispersive X-ray analyzer was used to examine all samples after testing. The first conclusion drawn is that reaction rates with TZM were not nearly as great as they were with WC 103. Second, the total reaction between GaAs and WC 103 was almost twice that with TZM. Therefore, even though WC 103 is easier to fabricate, at least half of the cartridge thickness will be degraded if contact is made with one of the semiconductor materials leading to a loss of strength properties.

  13. Design of a compact ultrahigh vacuum-compatible setup for the analysis of chemical vapor deposition processes

    SciTech Connect

    Weiss, Theodor; Nowak, Martin; Zielasek, Volkmar Bäumer, Marcus; Mundloch, Udo; Kohse-Höinghaus, Katharina

    2014-10-15

    Optimizing thin film deposition techniques requires contamination-free transfer from the reactor into an ultrahigh vacuum (UHV) chamber for surface science analysis. A very compact, multifunctional Chemical Vapor Deposition (CVD) reactor for direct attachment to any typical UHV system for thin film analysis was designed and built. Besides compactness, fast, easy, and at the same time ultimately clean sample transfer between reactor and UHV was a major goal. It was achieved by a combination of sample manipulation parts, sample heater, and a shutter mechanism designed to fit all into a NW38 Conflat six-ways cross. The present reactor design is versatile to be employed for all commonly employed variants of CVD, including Atomic Layer Deposition. A demonstration of the functionality of the system is provided. First results of the setup (attached to an Omicron Multiprobe x-ray photoelectron spectroscopy system) on the temperature dependence of Pulsed Spray Evaporation-CVD of Ni films from Ni acetylacetonate as the precursor demonstrate the reactor performance and illustrate the importance of clean sample transfer without breaking vacuum in order to obtain unambiguous results on the quality of CVD-grown thin Ni films. The widely applicable design holds promise for future systematic studies of the fundamental processes during chemical vapor deposition or atomic layer deposition.

  14. Design of a compact ultrahigh vacuum-compatible setup for the analysis of chemical vapor deposition processes

    NASA Astrophysics Data System (ADS)

    Weiss, Theodor; Nowak, Martin; Mundloch, Udo; Zielasek, Volkmar; Kohse-Höinghaus, Katharina; Bäumer, Marcus

    2014-10-01

    Optimizing thin film deposition techniques requires contamination-free transfer from the reactor into an ultrahigh vacuum (UHV) chamber for surface science analysis. A very compact, multifunctional Chemical Vapor Deposition (CVD) reactor for direct attachment to any typical UHV system for thin film analysis was designed and built. Besides compactness, fast, easy, and at the same time ultimately clean sample transfer between reactor and UHV was a major goal. It was achieved by a combination of sample manipulation parts, sample heater, and a shutter mechanism designed to fit all into a NW38 Conflat six-ways cross. The present reactor design is versatile to be employed for all commonly employed variants of CVD, including Atomic Layer Deposition. A demonstration of the functionality of the system is provided. First results of the setup (attached to an Omicron Multiprobe x-ray photoelectron spectroscopy system) on the temperature dependence of Pulsed Spray Evaporation-CVD of Ni films from Ni acetylacetonate as the precursor demonstrate the reactor performance and illustrate the importance of clean sample transfer without breaking vacuum in order to obtain unambiguous results on the quality of CVD-grown thin Ni films. The widely applicable design holds promise for future systematic studies of the fundamental processes during chemical vapor deposition or atomic layer deposition.

  15. SLR precision analysis for LAGEOS I and II

    NASA Astrophysics Data System (ADS)

    Kizilsu, Gaye; Sahin, Muhammed

    2000-10-01

    This paper deals with the problem of properly weighting satellite observations which are non-uniform in quality. The technique, the variance component estimation method developed by Helmert, was first applied to the 1987 LAGEOS I SLR data by Sahin et al. (1992). This paper investigates the performance of the globally distributed SLR stations using the Helmert type variance component estimation. As well as LAGEOS I data, LAGEOS II data were analysed, in order to compare with the previously analysed 1987 LAGEOS I data. The LAGEOS I and II data used in this research were obtained from the NASA Crustal Dynamics Data Information System (CDDIS), which archives data acquired from stations operated by NASA and by other U.S. and international organizations. The data covers the years 1994, 1995 and 1996. The analysis is based on "full-rate" laser observations, which consist of hundreds to thousands of ranges per satellite pass. The software used is based on the SATAN package (SATellite ANalysis) developed at the Royal Greenwich Observatory in the UK.

  16. Aerothermal Analysis of the Project Fire II Afterbody Flow

    NASA Technical Reports Server (NTRS)

    Wright, Michael J.; Loomis, Mark; Papadopoulos, Periklis; Arnold, James O. (Technical Monitor)

    2001-01-01

    Computational fluid dynamics (CFD) is used to simulate the wake flow and afterbody heating of the Project Fire II ballistic reentry to Earth at 11.4 km/sec. Laminar results are obtained over a portion of the trajectory between the initial heat pulse and peak afterbody heating. Although non-catalytic forebody convective heating results are in excellent agreement with previous computations, initial predictions of afterbody heating were about a factor of two below the experimental values. Further analysis suggests that significant catalysis may be occurring on the afterbody heat shield. Computations including finite-rate catalysis on the afterbody surface are in good agreement with the data over the early portion of the trajectory, but are conservative near the peak afterbody heating point, especially on the rear portion of the conical frustum. Further analysis of the flight data from Fire II shows that peak afterbody heating occurs before peak forebody heating, a result that contradicts computations and flight data from other entry vehicles. This result suggests that another mechanism, possibly pyrolysis, may be occurring during the later portion of the trajectory, resulting in less total heat transfer than the current predictions.

  17. Safety analysis report for the TRUPACT-II shipping package (condensed version). Volume 1, Rev. 14

    SciTech Connect

    1994-10-01

    The condensed version of the TRUPACT-II Contact Handled Transuranic Waste Safety Analysis Report for Packaging (SARP) contains essential material required by TRUPACT-II users, plus additional contents (payload) information previously submitted to the U.S. Nuclear Regulatory Commission. All or part of the following sections, which are not required by users of the TRUPACT-II, are deleted from the condensed version: (i) structural analysis, (ii) thermal analysis, (iii) containment analysis, (iv) criticality analysis, (v) shielding analysis, and (vi) hypothetical accident test results.

  18. Genetic diversity of Datisca cannabina-compatible Frankia strains as determined by sequence analysis of the PCR-amplified 16S rRNA gene.

    PubMed Central

    Mirza, M S; Hameed, S; Akkermans, A D

    1994-01-01

    The presence of Frankia strains in soil samples collected from northern areas of Pakistan was detected by inoculating Coriaria nepalensis and Datisca cannabina plants. The abundance of compatible Frankia strains in some areas was indicated by profuse nodulation of the host plants, whereas soil samples from other localities failed to result in nodulation. An oligonucleotide probe (COR/DAT) directed against the 16S rRNA gene of the endophytes of Coriaria and Datisca spp. that did not cross-react with the RNA gene of Frankia strains isolated from other hosts was developed. Genetic diversity among Frankia strains nodulating D. cannabina was determined by sequence analysis of the partial 16S rRNA gene amplified from nodules induced by soil samples from different localities by PCR. Four types of Frankia sequences and one non-Frankia sequence were detected by hybridization with a Frankia genus probe and the COR/DAT probe as well as by sequence analysis of the cloned PCR products. Images PMID:7521157

  19. Analysis of Hemoglobin Glycation Using Microfluidic CE-MS: A Rapid, Mass Spectrometry Compatible Method for Assessing Diabetes Management.

    PubMed

    Redman, Erin A; Ramos-Payan, Maria; Mellors, J Scott; Ramsey, J Michael

    2016-05-17

    to provide a more complete picture of a patient's glycemic control in the months leading up to blood collection. The results presented here demonstrate that the microfluidic CE-MS method is capable of rapidly assessing Hb and HSA glycation from low volumes of whole blood with minimal sample preparation and has the potential to provide more information in a single analysis step than current technologies. PMID:27100069

  20. Aircraft electromagnetic compatibility

    NASA Technical Reports Server (NTRS)

    Clarke, Clifton A.; Larsen, William E.

    1987-01-01

    Illustrated are aircraft architecture, electromagnetic interference environments, electromagnetic compatibility protection techniques, program specifications, tasks, and verification and validation procedures. The environment of 400 Hz power, electrical transients, and radio frequency fields are portrayed and related to thresholds of avionics electronics. Five layers of protection for avionics are defined. Recognition is given to some present day electromagnetic compatibility weaknesses and issues which serve to reemphasize the importance of EMC verification of equipment and parts, and their ultimate EMC validation on the aircraft. Proven standards of grounding, bonding, shielding, wiring, and packaging are laid out to help provide a foundation for a comprehensive approach to successful future aircraft design and an understanding of cost effective EMC in an aircraft setting.

  1. Aircraft electromagnetic compatibility

    NASA Astrophysics Data System (ADS)

    Clarke, Clifton A.; Larsen, William E.

    1987-06-01

    Illustrated are aircraft architecture, electromagnetic interference environments, electromagnetic compatibility protection techniques, program specifications, tasks, and verification and validation procedures. The environment of 400 Hz power, electrical transients, and radio frequency fields are portrayed and related to thresholds of avionics electronics. Five layers of protection for avionics are defined. Recognition is given to some present day electromagnetic compatibility weaknesses and issues which serve to reemphasize the importance of EMC verification of equipment and parts, and their ultimate EMC validation on the aircraft. Proven standards of grounding, bonding, shielding, wiring, and packaging are laid out to help provide a foundation for a comprehensive approach to successful future aircraft design and an understanding of cost effective EMC in an aircraft setting.

  2. Thermoelectric efficiency and compatibility.

    PubMed

    Snyder, G Jeffrey; Ursell, Tristan S

    2003-10-01

    The intensive reduced efficiency eta(r) is derived for thermoelectric power generation (in one dimension) from intensive fields and currents, giving eta(r)=(E x J) divided by (- inverted Delta)T x J(S). The overall efficiency is derivable from a thermodynamic state function, Phi=1 divided by u + alphaT, where we introduce u=J divided by kappa (inverted Delta)T as the relative current density. The method simplifies the computation and clarifies the physics behind thermoelectric devices by revealing a new materials property s=(sqrt[1+zT]-1) divided by (alphaT), which we call the compatibility factor. Materials with dissimilar compatibility factors cannot be combined by segmentation into an efficient thermoelectric generator because of constraints imposed on u. Thus, control of the compatibility factor s is, in addition to z, essential for efficient operation of a thermoelectric device, and thus will facilitate rational materials selection, device design, and the engineering of functionally graded materials. PMID:14611561

  3. Potassium Fluxes in Chlamydomonas reinhardtii (II. Compartmental Analysis).

    PubMed Central

    Malhotra, B.; Glass, ADM.

    1995-01-01

    42K+ and 86Rb+ were used to determine the subcellular distribution of potassium in Chlamydomonas reinhardtii by compartmental analysis. In both wild type and a mutant strain, three distinct compartments (referred to as I, II, and III) were apparent. Using 42K+, we found that these had half-lives for K+ exchange of 1.07 min, 12.8 min, and 2.9 h, respectively, in wild-type cells and 0.93 min, 14.7 min, and 9.8 h, respectively, for the mutants. Half-lives were not significantly different when 86Rb+ was used to trace K+. Compartments I and II probably correspond to the cell wall and cytoplasm, respectively. Based on the lack of a large central vacuole in Chlamydomonas, the effect of a dark pretreatment on the kinetic properties of compartment III and the similarity between the [K+] of compartment III and that of isolated chloroplasts, this slowly exchanging compartment was identified as the chloroplast. Growth of wild-type cells at 100 [mu]M (instead of 10 mM K+) caused no change of cytoplasmic [K+] but reduced chloroplast [K+] very substantially. The mutants failed to grow at 100 [mu]M K+. PMID:12228560

  4. Material compatibility with gaseous fluorine

    NASA Technical Reports Server (NTRS)

    Price, Harold G , Jr; Douglass, Howard W

    1957-01-01

    Static tests on the compatibility of fluorine with non-metals at atmospheric temperature eliminated many materials from further consideration for use in fluorine systems. Several materials were found compatible at atmospheric pressures. Only Teflon and ruby (aluminum oxide) were compatible at 1500 pounds per square inch gage.

  5. From compatible factorization to near-compatible factorization

    NASA Astrophysics Data System (ADS)

    Aldiabat, Raja'i.; Ibrahim, Haslinda

    2014-12-01

    A compatible factorization of order ν, is an ν× ν-1/2 array in which the entries in row i form a near-one-factor with focus i, and the triples associated with the rows contain no repetitions. In this paper, we aim to amend this compatible factorization so that we can display ν(ν-1)/2 - 2ν/3 triples with the minimum repeated triples. Throughout this paper we propose a new type of factorization called near-compatible factorization. First, we present the compatible factorization towards developing a near-compatible factorization. Second, we discuss briefly the necessary and sufficient conditions for the existence of near-compatible factorization. Then, we exemplify the construction for case ν = 9 as a groundwork in developing near-compatible factorization.

  6. Parametric cost analysis of a HYLIFE-II power plant

    SciTech Connect

    Bieri, R.L. Massachusetts Inst. of Tech., Cambridge, MA )

    1990-10-04

    The SAFIRE (Systems Analysis for ICF Reactor Economics) code was adapted to model a power plant using a HYLIFE-II reactor chamber. The code was then used to examine the dependence of the plant capital costs and busbar cost of electricity (COE) on a variety of design parameters (type of driver, chamber repetition rate, and net electric power). The results show the most attractive operating space for each set of driver/target assumptions and quantify the benefits of improvements in key design parameters. The base case plant was a 1,000 MWe plant containing a reactor vessel driven by an induction linac heavy ion accelerator run at 7.3 Hz with a driver energy of 5 MJ and a target yield of 370 MJ. The total direct cost for this plant was 2,800 M$ (where all $ in this paper are 1988$s), and the COE was 9 {cents}/KW*hour. The COE and total capital costs for the base plant assumptions for a 1,000 MWe plant are approximately independent of chosen repetition rate for all repetition rates between 4 and 10 Hz. For comparison, the COE for a coal or future fission plant would be 4.5--5.5 {cents}/KW*hour. The COE for a 1,000 MWe plant could be reduced to 7.6 {cents}/KW*hour by using advanced targets and could be cut to 6.8 {cents}/KW*hour with conventional targets if the driver cost could be cut in half. There is a large economy of scale with heavy ion driven ICF plants; a 5,000 MWe plant with one heavy ion driver and either one or two HYLIFE-II chambers would have a COE of only 4.4 {cents}/KW*hour.

  7. OGLE II Eclipsing Binaries In The LMC: Analysis With Class

    NASA Astrophysics Data System (ADS)

    Devinney, Edward J.; Prsa, A.; Guinan, E. F.; DeGeorge, M.

    2011-01-01

    The Eclipsing Binaries (EBs) via Artificial Intelligence (EBAI) Project is applying machine learning techniques to elucidate the nature of EBs. Previously, Prsa, et al. applied artificial neural networks (ANNs) trained on physically-realistic Wilson-Devinney models to solve the light curves of the 1882 detached EBs in the LMC discovered by the OGLE II Project (Wyrzykowski, et al.) fully automatically, bypassing the need for manually-derived starting solutions. A curious result is the non-monotonic distribution of the temperature ratio parameter T2/T1, featuring a subsidiary peak noted previously by Mazeh, et al. in an independent analysis using the EBOP EB solution code (Tamuz, et al.). To explore this and to gain a fuller understanding of the multivariate EBAI LMC observational plus solutions data, we have employed automatic clustering and advanced visualization (CAV) techniques. Clustering the OGLE II data aggregates objects that are similar with respect to many parameter dimensions. Measures of similarity for example, could include the multidimensional Euclidean Distance between data objects, although other measures may be appropriate. Applying clustering, we find good evidence that the T2/T1 subsidiary peak is due to evolved binaries, in support of Mazeh et al.'s speculation. Further, clustering suggests that the LMC detached EBs occupying the main sequence region belong to two distinct classes. Also identified as a separate cluster in the multivariate data are stars having a Period-I band relation. Derekas et al. had previously found a Period-K band relation for LMC EBs discovered by the MACHO Project (Alcock, et al.). We suggest such CAV techniques will prove increasingly useful for understanding the large, multivariate datasets increasingly being produced in astronomy. We are grateful for the support of this research from NSF/RUI Grant AST-05-75042 f.

  8. Hydrazine Materials Compatibility Database

    NASA Astrophysics Data System (ADS)

    Schmidt, E. W.

    2004-10-01

    Anhydrous hydrazine and its methyl derivatives MMH and UDMH have been safely used as monopropellants and bipropellant fuels in thousands of satellites and space probes, hundreds of expendable launch vehicles and hundreds of piloted reusable launch vehicle flights. The term hydrazine(s) is used here to describe the three propellant hydrazines and their mixtures. Over the years, a significant amount of experience has accumulated in the selection of compatible materials of construction for these and other rocket propellants. Only a few materials incompatibility issues have arisen in the recent past. New materials of construction have become available during the past decades which have not yet been extensively tested for long-term compatibility with hydrazine(s). These new materials promise lightweight (i. e., lighter weight) propulsion system designs and increased payloads in launch vehicles and satellites. Other new materials offer reduced contamination caused by leached ingredients, e. g. less silica leaching from diaphragms in propellant management devices in propellant tanks. This translates into longer mission life.

  9. Tank 241-SY-102 January 2000 Compatibility Grab Samples Analytical Results for the Final Report [SEC 1 and 2

    SciTech Connect

    BELL, K.E.

    2000-05-11

    This document is the format IV, final report for the tank 241-SY-102 (SY-102) grab samples taken in January 2000 to address waste compatibility concerns. Chemical, radiochemical, and physical analyses on the tank SY-102 samples were performed as directed in Comparability Grab Sampling and Analysis Plan for Fiscal Year 2000 (Sasaki 1999). No notification limits were exceeded. Preliminary data on samples 2SY-99-5, -6, and -7 were reported in ''Format II Report on Tank 241-SY-102 Waste Compatibility Grab Samples Taken in January 2000'' (Lockrem 2000). The data presented here represent the final results.

  10. Solar Electric Generating System II finite element analysis

    SciTech Connect

    Dohner, J.L.; Anderson, J.R.

    1994-04-01

    On June 2, 1992, Landers` earthquake struck the Solar Electric Generating System II, located in Daggett, California. The 30 megawatt power station, operated by the Daggett Leasing Corporation (DLC), suffered substantial damage due to structural failures in the solar farm. These failures consisted of the separation of sliding joints supporting a distribution of parabolic glass mirrors. At separation, the mirrors fell to the ground and broke. It was the desire of the DLC and the Solar Thermal Design Assistance Center (STDAC) of Sandia National Laboratories (SNL) and to redesign these joints so that, in the event of future quakes, costly breakage will be avoided. To accomplish this task, drawings of collector components were developed by the STDAC, from which a detailed finite element computer model of a solar collector was produced. This nonlinear dynamic model, which consisted of over 8,560 degrees of freedom, underwent model reduction to form a low order nonlinear dynamic model containing only 40 degrees of freedom. This model was then used as a design tool to estimate joint dynamics. Using this design tool, joint configurations were modified, and an acceptable joint redesign determined. The results of this analysis showed that the implementation of metal stops welded to support shafts for the purpose of preventing joint separation is a suitable joint redesign. Moreover, it was found that, for quakes of Landers` magnitude, mirror breakage due to enhanced vibration in the trough assembly is unlikely.

  11. Genetic analysis of the Aspergillus flavus vegetative compatibility group to which a biological control agent that limits aflatoxin contamination in USA crops belongs

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The most effective means of reducing aflatoxin contamination of agricultural crops is through competitive exclusion of aflatoxin-producing fungi using vegetative compatibility groups (VCGs) of Aspergillus flavus that do not produce aflatoxin. Presently there are two VCGs in the USA registered with t...

  12. A time-course comparative microarray analysis of an incompatible and compatible response by Glycine max (soybean) to Heterodera glycines (soybean cyst nematode) infection

    Technology Transfer Automated Retrieval System (TEKTRAN)

    The development of infection in soybean cv. Peking roots by compatible or incompatible races of Heterodera glycines (soybean cyst nematode [SCN]) was assayed by microarray analyses. Using three time-points, one as nematodes penetrate the root prior to feeding site selection; a second as the nematode...

  13. Laser capture microdissection (LCM) and comparative microarray expression analysis of syncytial cells isolated from incompatible and compatible soybean roots infected by soybean cyst nematode (Heterodera glycines)

    Technology Transfer Automated Retrieval System (TEKTRAN)

    Syncytial cells in soybean (Glycine max cultivar [cv.] Peking) roots infected by incompatible (I) and compatible (C) populations of soybean cyst nematode [SCN] (Heterodera glycines) were collected using laser capture microdissection. Gene transcript abundance was assayed using an Affymetrix® soybean...

  14. Reference manual for generation and analysis of Habitat Time Series: version II

    USGS Publications Warehouse

    Milhous, Robert T.; Bartholow, John M.; Updike, Marlys A.; Moos, Alan R.

    1990-01-01

    by the Aquatic Systems Branch of the National Ecology Research Center. For more information about the TSLIB software, refer to the Memorandum of Understanding. Chapter 1 provides a brief introduction to the Instream Flow Incremental Methodology and TSLIB. Other chapters in this manual provide information on the different aspects of using the models. The information contained in the other chapters includes (2) acquisition, entry, manipulation, and listing of streamflow data; (3) entry, manipulation, and listing of the habitat-versus-streamflow function; (4) transferring streamflow data; (5) water resources systems analysis; (6) generation and analysis of daily streamflow and habitat values; (7) generation of the time series of monthly habitats; (8) manipulation, analysis, and display of month time series data; and (9) generation, analysis, and display of annual time series data. Each section includes documentation for the programs therein with at least one page of information for each program, including a program description, instructions for running the program, and sample output. The Appendixes contain the following: (A) sample file formats; (B) descriptions of default filenames; (C) alphabetical summary of batch-procedure files; (D) installing and running TSLIB on a microcomputer; (E) running TSLIB on a CDC Cyber computer; (F) using the TSLIB user interface program (RTSM); and (G) running WATSTORE on the USGS Amdahl mainframe computer. The number for this version of TSLIB--Version II-- is somewhat arbitrary, as the TSLIB programs were collected into a library some time ago; but operators tended to use and manage them as individual programs. Therefore, we will consider the group of programs from the past that were only on the CDC Cyber computer as Version 0; the programs from the past that were on both the Cyber and the IBM-compatible microcomputer as Version I; and the programs contained in this reference manual as Version II.

  15. Molecular analysis of carnitine palmitoyltransferase II deficiency with hepatocardiomuscular expression.

    PubMed Central

    Bonnefont, J. P.; Taroni, F.; Cavadini, P.; Cepanec, C.; Brivet, M.; Saudubray, J. M.; Leroux, J. P.; Demaugre, F.

    1996-01-01

    Carnitine palmitoyltransferase (CPT) II deficiency, an inherited disorder of mitochondrial long-chain fatty-acid (LCFA) oxidation, results in two distinct clinical phenotypes, namely, an adult (muscular) form and an infantile (hepatocardiomuscular) form. The rationale of this phenotypic heterogeneity is poorly understood. The adult form of the disease is commonly ascribed to the Ser-113-Leu substitution in CPT II. Only few data are available regarding the molecular basis of the infantile form of the disease. We report herein a homozygous A-2399-C transversion predicting a Tyr-628-Ser substitution in a CPT II-deficient infant. In vitro expression of mutant cDNA in COS-1 cells demonstrated the responsibility of this mutation for the disease. Metabolic consequences of the SER-113-Leu and Tyr-628-Ser substitutions were studied in fibroblasts. The Tyr-628-Ser substitution (infantile form) resulted in a 10% CPT II residual activity, markedly impairing LCFA oxidation, whereas the Ser-113-Leu substitution (adult form) resulted in a 20% CPT II residual activity, with out consequence on LCFA oxidation. These data show that CPT II activity has to be reduced below a critical threshold in order for LCFA oxidation in fibroblasts to be impaired. The hypothesis that this critical threshold differs among tissues could provide a basis to explain phenotypic heterogeneity of CPT II deficiency. Images Figure 1 Figure 2 Figure 3 Figure 4 PMID:8651281

  16. Analysis of xylosyltransferase II binding to the anticoagulant heparin

    SciTech Connect

    Casanova, Javier Carrera; Ambrosius, Michael; Kuhn, Joachim; Kleesiek, Knut; Goetting, Christian

    2009-05-22

    The key enzymes in the biosynthetic pathway of glycosaminoglycan production are represented by the human xylosyltransferase I and its isoform II (XylT-I and XylT-II). The glycosaminoglycan heparin interacts with a variety of proteins, thereby regulating their activities, also those of xylosyltransferases. The identification of unknown amino acids responsible for heparin-binding of XylT-II was addressed in this study. Thus, six XylT-II fragments were designed as fusion proteins with MBP and we received soluble and purified MBP/XylT-II from Escherichia coli. Heparin-binding studies showed that all fragments bound with low affinity to heparin. Prolonging of XylT-II fragments did not account for a cooperative effect of multiple heparin-binding motifs and in turn for a stronger heparin-binding. Sequence alignment and surface polarity plot led to the identification of two highly positively charged Cardin-Weintraub motifs with surface accessibility, resulting in combination with short clusters of basic amino acids for strong heparin-binding of native xylosyltransferases.

  17. Electro-magnetic compatibility

    NASA Astrophysics Data System (ADS)

    Maidment, H.

    1980-05-01

    The historical background to the growth in problems of electromagnetic compatibility (EMC) in UK Military aircraft is reviewed and the present approach for minimizing these problems during development is discussed. The importance of using representative aircraft for final EMC assessments is stressed, and the methods of approach in planning and executing such tests are also outlined. The present equipment qualification procedures are based on assumptions regarding the electromagnetic fields present within the airframe, and the nature of the coupling mechanisms. These cannot be measured with any certainty in representative aircraft. Thus EMC assessments rely on practical tests. Avionics systems critical to flight safety, and systems vital to mission effectiveness require test methods that provide a measure of the safety and performance margins available to account for variations that occur in production and service use. Some proven methods are available, notably for detonator circuits, but in most other areas further work is required. Encouraging process has been made in the use of current probes for the measurement of interfering signals on critical signal lines, in conjunction with complementary test house procedures, as a means for obtaining the safety margins required in flight and engine control systems. Performance margins for mission systems using digital techniques are difficult to determine, and there is a need for improved test techniques. The present EMC qualification tests for equipment in the laboratory do not guarantee freedom from interference when installed, and the results are limited in value for correlating with aircraft tests.

  18. Genetic Diversity of Isolates of Glomus mosseae from Different Geographic Areas Detected by Vegetative Compatibility Testing and Biochemical and Molecular Analysis

    PubMed Central

    Giovannetti, Manuela; Sbrana, Cristiana; Strani, Patrizia; Agnolucci, Monica; Rinaudo, Valeria; Avio, Luciano

    2003-01-01

    We detected, for the first time, the occurrence of vegetative incompatibility between different isolates of the arbuscular mycorrhizal fungal species Glomus mosseae. Vegetative compatibility tests performed on germlings belonging to the same isolate showed that six geographically different isolates were capable of self-anastomosing, and that the percentage of hyphal contacts leading to fusions ranged from 60 to 85%. Successful anastomoses were characterized by complete fusion of hyphal walls, protoplasm continuity and occurrence of nuclei in the middle of hyphal bridges. No anastomoses could be detected between hyphae belonging to different isolates, which intersected without any reaction in 49 to 68% of contacts. Microscopic examinations detected hyphal incompatibility responses in diverse pairings, consisting of protoplasm retraction from the tips and septum formation in the approaching hyphae, even before physical contact with neighboring hyphae. Interestingly, many hyphal tips showed precontact tropism, suggesting that specific recognition signals may be involved during this stage. The intraspecific genetic diversity of G. mosseae revealed by vegetative compatibility tests was confirmed by total protein profiles and internal transcribed spacer-restriction fragment length polymorphism profiles, which evidenced a higher level of molecular diversity between the two European isolates IMA1 and BEG25 than between IMA1 and the two American isolates. Since arbuscular mycorrhizal fungi lack a tractable genetic system, vegetative compatibility tests may represent an easy assay for the detection of genetically different mycelia and an additional powerful tool for investigating the population structure and genetics of these obligate symbionts. PMID:12514049

  19. Simultaneous Determination of Nine Active Compounds of the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang and Analysis of the Relationship between Therapeutical Effect and Compatibility of Medicines

    PubMed Central

    Zhang, Guijun; Wang, Meng; Wang, Jingjuan; Zeng, Weixin; Gao, Xiaomei

    2014-01-01

    A simple and sensitive HPLC-DAD detection method was established for the simultaneous determination of nine compounds including oxypaeoniflorin, albiflorin, paeoniflorin, benzoylpaeoniflorin, glycyrrhizic acid, liquiritin, isoliquiritin, liquiritigenin, and isoliquiritigenin in the Traditional Chinese Medicinal Prescription Shaoyao-Gancao-Tang (SGT) and we analyze the relationship between therapeutical effect and compatibility of medicines by using an Agilent extend-C18 column at a flow rate of 1 mL/min. The column temperature was maintained at 30°C and the detection wavelength was set at 230 nm for oxypaeoniflorin, albiflorin, paeoniflorin, benzoylpaeoniflorin, and glycyrrhizic acid; 276 nm for liquiritin and liquiritigenin; 360 nm for isoliquiritin and isoliquiritigenin. The total contents of the nine compounds in SGT varied from 4.65 to 20.06 mg/mL. The results of this study showed that the content of chemical compounds of Traditional Chinese Medicinal Prescription is mainly influenced by the dosage and compatibility of medicines and the therapeutical effect of Traditional Chinese Medicinal prescription is mainly influenced by the dosage and compatibility of medicines. The method could be suitable for quality control of SGT with bioactive multicompounds. PMID:25431610

  20. An ICF-CY-Based Content Analysis of the Vineland Adaptive Behavior Scales-II

    ERIC Educational Resources Information Center

    Gleason, Kara; Coster, Wendy

    2012-01-01

    Background: The International Classification of Functioning, Disability and Health (ICF), and its version for children and youth (ICF-CY), has been increasingly adopted as a system to describe function and disability. A content analysis of the Vineland Adaptive Behavior Scales-II (VABS-II) was conducted to examine congruence with the functioning…

  1. PIV Analysis of Cavitation Flow Characteristics of He II

    SciTech Connect

    Harada, K.; Murakami, M.

    2006-04-27

    In the present experimental study cavitation phenomena in both He I and He II flows were investigated through the application of the PIV technique and visual observation under the saturated vapor pressure condition. The cavitation flow was generated in the downstream regions of a Venturi channel and a converging jet nozzle driven by a contracting metal bellows. It is seen that cavitation inception is a kind of stochastic process and has definite temperature dependence. The spatial distribution of the cavitation bubble velocity is measured by using the PIV technique. Some differences in the cavitating flow pattern and the void fraction are found between He II and He I cavitating flows. The PIV result indicates that the void fraction for He II flow is larger than that for He I flow.

  2. Carnitine palmitoyltransferase II (CPT II) deficiency: genotype-phenotype analysis of 50 patients.

    PubMed

    Joshi, Pushpa Raj; Deschauer, Marcus; Zierz, Stephan

    2014-03-15

    Clinical, biochemical and molecular genetic data in a cohort of 50 patients with muscle CPT II deficiency are reported. Attacks of myoglobinuria occurred in 86% of patients. In 94% of patients the triggering factor was exercise. Although the myopathic form is often called the adult from, in 60% of patients, the age of onset was in childhood (1-12 years). All the patients in whom biochemical activity was measured had normal enzyme activity of total CPT I+II but the activity was significantly inhibited by malonyl-CoA and Triton. The p.S113L mutation was detected in 38/40 index patients (95%) in at least one allele. Sixty percent of index patients were homozygous for this mutation. Thirteen other mutations, all in compound heterozygote form, were also identified. There was no significant difference in ages of onset, clinical and biochemical phenotype of patients with p.S113L mutation in homozygous or compound heterozygous form. The exception was a tendency of slightly higher residual enzyme activity upon malonyl-CoA inhibition in compound heterozygotes. Phenotype was also not significantly different in patients with missense mutations on both alleles and patients with truncating mutation on one allele and missense mutation on the other allele. However, the only exception was that, attacks were triggered by fasting in almost all the patients with truncating mutations. In contrast, fasting triggered the attacks only in one third of patients with missense mutations on both alleles. The data indicate that within the muscle form of CPT II deficiency, the various genotypes have only marginal influence on the clinical and biochemical phenotype. PMID:24398345

  3. Compatible Spatial Discretizations for Partial Differential Equations

    SciTech Connect

    Arnold, Douglas, N, ed.

    2004-11-25

    simulations. + Identification and design of compatible spatial discretizations of PDEs, their classification, analysis, and relations. + Relationships between different compatible spatial discretization methods and concepts which have been developed; + Impact of compatible spatial discretizations upon physical fidelity, verification and validation of simulations, especially in large-scale, multiphysics settings. + How solvers address the demands placed upon them by compatible spatial discretizations. This report provides information about the program and abstracts of all the presentations.

  4. BESAFE II: Accident safety analysis code for MFE reactor designs

    NASA Astrophysics Data System (ADS)

    Sevigny, Lawrence Michael

    The viability of controlled thermonuclear fusion as an alternative energy source hinges on its desirability from an economic and an environmental and safety standpoint. It is the latter which is the focus of this thesis. For magnetic fusion energy (MFE) devices, the safety concerns equate to a design's behavior during a worst-case accident scenario which is the loss of coolant accident (LOCA). In this dissertation, we examine the behavior of MFE devices during a LOCA and how this behavior relates to the safety characteristics of the machine; in particular the acute, whole-body, early dose. In doing so, we have produced an accident safety code, BESAFE II, now available to the fusion reactor design community. The Appendix constitutes the User's Manual for BESAFE II. The theory behind early dose calculations including the mobilization of activation products is presented in Chapter 2. Since mobilization of activation products is a strong function of temperature, it becomes necessary to calculate the thermal response of a design during a LOCA in order to determine the fraction of the activation products which are mobilized and thus become the source for the dose. The code BESAFE II is designed to determine the temperature history of each region of a design and determine the resulting mobilization of activation products at each point in time during the LOCA. The BESAFE II methodology is discussed in Chapter 4, followed by demonstrations of its use for two reference design cases: a PCA-Li tokamak and a SiC-He tokamak. Of these two cases, it is shown that the SiC-He tokamak is a better design from an accident safety standpoint than the PCA-Li tokamak. It is also found that doses derived from temperature-dependent mobilization data are different than those predicted using set mobilization categories such as those that involve Piet fractions. This demonstrates the need for more experimental data on fusion materials. The possibility for future improvements and modifications

  5. Sorption selectivity of birnessite particle edges: a d-PDF analysis of Cd(ii) and Pb(ii) sorption by δ-MnO2 and ferrihydrite.

    PubMed

    van Genuchten, Case M; Peña, Jasquelin

    2016-08-10

    Birnessite minerals (layer-type MnO2), which bear both internal (cation vacancies) and external (particle edges) metal sorption sites, are important sinks of contaminants in soils and sediments. Although the particle edges of birnessite minerals often dominate the total reactive surface area, especially in the case of nanoscale crystallites, the metal sorption reactivity of birnessite particle edges remains elusive. In this study, we investigated the sorption selectivity of birnessite particle edges by combining Cd(ii) and Pb(ii) adsorption isotherms at pH 5.5 with surface structural characterization by differential pair distribution function (d-PDF) analysis. We compared the sorption reactivity of δ-MnO2 to that of the nanomineral, 2-line ferrihydrite, which exhibits only external surface sites. Our results show that, whereas Cd(ii) and Pb(ii) both bind to birnessite layer vacancies, only Pb(ii) binds extensively to birnessite particle edges. For ferrihydrite, significant Pb(ii) adsorption to external sites was observed (roughly 20 mol%), whereas Cd(ii) sorption was negligible. These results are supported by bond valence calculations that show comparable degrees of saturation of oxygen atoms on birnessite and ferrihydrite particle edges. Therefore, we propose that the sorption selectivity of birnessite edges follows the same order of that reported previously for ferrihydrite: Ca(ii) < Cd(ii) < Ni(ii) < Zn(ii) < Cu(ii) < Pb(ii). PMID:27183472

  6. Harmonic Resonance Analysis for PEP II Power Factor Control Upgrades

    NASA Astrophysics Data System (ADS)

    Corvin, C.

    1997-05-01

    Recent upgrades to the high voltage utility distribution network at the Stanford Linear Accelerator Center have been accompanied by the installation of a large number of power supplies associated with the PEP-II B Factory project. These power supplies include a diverse assortment of single and three phase units, in two, six and twelve pulse configurations, with chopped, pulsed and continuous loading. Viewed as harmonic power sources in a range from a hundred to several kilohertz, they have the potential to be in resonance with the utility system network, a condition to be avoided. This paper analyzes and evaluates these resonance conditions with a view toward adding electric power factor correction upgrades to achieve substantial cost savings associated with power factor penalty avoidance. Similar studies and upgrades at SLAC in the past have reduced electric power costs over time by several hundred thousand dollars, thus providing the incentive to evaluate the recent upgrades to the PEP-II utility network.

  7. An analysis of the coma of comet Bennett 1970 II

    NASA Technical Reports Server (NTRS)

    Oppenheimer, M.

    1978-01-01

    Brightness profiles for emission features of H2O(+) in comet Bennett 1970 II are analyzed, taking into account the role of chemical reactions in the coma. By comparing the rates of transport processes derived from the brightness profile with known chemical rate constants, upper limits on the abundances and production rates of H2O, CH4, NH3, and other possible coma constituents are found. The derived upper limit on the H2O production rate inside 10 to the 4th power km is less than the observed OH production rate averaged over the coma of this comet. It is concluded that the brightness profiles of H2O(+) and OH in comet Bennett 1970 II which are presently available are inconsistent with production of OH primarily by photodissociation of H2O molecules sublimating from the nucleus. The existence of an extended source of H2O is not ruled out.

  8. Elastic analysis of a mode II fatigue crack test specimen

    NASA Technical Reports Server (NTRS)

    Gross, B.; Buzzard, R. J.; Brown, W. F., Jr.

    1986-01-01

    Elastic displacements and stress intensity measurements for a mode II specimen have been obtained over a range of a/W values between 0.500 and 0.900 using the MARC general purpose finite element program. Stress intensity factors were experimentally determined using load point displacement values. Good general agreement between numerical and experimental results for crack mouth, crack surface, and load point displacements, and for stress intensity factors, demonstrates the accuracy of the present method.

  9. Aerothermodynamic Analysis of the Project FIRE II Afterbody Flow

    NASA Technical Reports Server (NTRS)

    Wright, Micheal J.; Loomis, Mark; Arnold, Jim (Technical Monitor)

    2000-01-01

    35 years later, the Project FIRE II ballistic reentry to Earth at a nominal velocity of 11.4 km/s remains one of the best sources of heating data for the design of sample return capsules. The data from this flight experiment encompass both the thermochemical non-equilibrium and equilibrium flow regimes and include measurements of both radiative and total heating on the forebody and afterbody. Because of this, a number of researchers have performed computational fluid dynamics (CFD) simulations of the forebody of the FIRE II entry vehicle, with generally good results. In particular, Olynick et. al. coupled a Navier-Stokes solver (GIANTS) with a radiation code (NOVAR) and showed excellent agreement in surface heat transfer over the FIRE II trajectory between 1634 and 1651 seconds (77 km to 37 km). However, in most cases the primary motivation of the previous work was to understand and model the coupling between shock layer radiation and aerothermodynamics, and thus the simulations concentrated on the forebody flow only. To our knowledge there have been no prior published attempts to reproduce the afterbody heating data. However, an understanding of this data is critical to our efforts to design the next generation of Earth and planetary entry vehicles and to assess our need for additional flight data.

  10. COMPATIBILITY OF BENTONITE AND DNAPLS

    EPA Science Inventory

    The compatibility of dense non-aqueous phase liquids (DNAPLs), trichloroethylene (TCE), methylene chloride (MC), and creosote with commercially available sodium bentonite pellets was evaluated using stainless steel, double-ring, falling-head permeameters. The Hydraulic conductiv...

  11. Participation by women in behavior analysis. II: 1992

    PubMed Central

    Myers, David L.

    1993-01-01

    Participation by women and men in (a) the editorial process and publication of three behavior analysis journals, (b) leadership in the Association for Behavior Analysis (ABA) and the Society for the Experimental Analysis of Behavior, and (c) participation in the 1982 and 1991 conventions of the Association for Behavior Analysis are described. The data indicate that the relative involvement of women in all three areas is lower than the percentage of ABA members who are women (31%) and is considerably lower than the percentage of women in society at large (51%). This underrepresentation of women in editorial and leadership roles in behavior analysis mirrors the reported phenomenon of a glass ceiling for women in leadership roles in business and industry. The men who control our institutions are asked to share power and responsibility by increasing the involvement of women in behavior analysis. PMID:22478136

  12. Molecular cloning, expression, and evolution analysis of type II CHI gene from peanut (Arachis hypogaea L.).

    PubMed

    Liu, Yu; Zhao, Shuzhen; Wang, Jiangshan; Zhao, Chuanzhi; Guan, Hongshan; Hou, Lei; Li, Changsheng; Xia, Han; Wang, Xingjun

    2015-01-01

    Chalcone isomerase (CHI) plays critical roles in plant secondary metabolism, which is important for the interaction between plants and the environment. CHI genes are widely studied in various higher plants. However, little information about CHI genes is available in peanut. Based on conservation of CHI gene family, we cloned the peanut type II CHI gene (AhCHI II) cDNA and genome sequence. The amino acid sequence of peanut CHI II was highly homologous to type II CHI from other plant species. qRT-PCR results showed that peanut CHI II is mainly expressed in roots; however, peanut CHI I is mainly expressed in tissues with high content of anthocyanin. Gene duplication and gene cluster analysis indicated that CHI II was derived from CHI I 65 million years ago approximately. Our gene structure analysis results are not in agreement with the previous hypothesis that CHI II was derived from CHI I by the insertion of an intron into the first exon. Moreover, no positive selection pressure was found in CHIs, while, 32.1 % of sites were under neutral selection, which may lead to mutation accumulation and fixation during great changes of environment. PMID:25608978

  13. Impedance analysis of the PEP-II vacuum chamber

    SciTech Connect

    Ng, C.K.; Weiland, T.

    1995-05-01

    The PEP-II high energy ring (HER) vacuum chamber consists of a copper tube with periodically spaced pumping slots. The impedance of the vacuum chamber due to the slots is analyzed. Both narrow-band and broadband impedances are considered as well as longitudinal and transverse components thereof. It is found that although the broad-band impedance is tolerable, the narrow-band impedance may exceed the instability limit given by the natural damping with no feedback system on. Traveling wave modes in the chamber are the major source of this high value narrow-band impedance. We also study the dependences of the impedance on the slot length and the geometrical cross section.

  14. Analysis of NASA communications (Nascom) II network protocols and performance

    NASA Technical Reports Server (NTRS)

    Omidyar, Guy C.; Butler, Thomas E.

    1991-01-01

    The NASA Communications (Nascom) Division of the Mission Operations and Data Systems Directorate is to undertake a major initiative to develop the Nascom II (NII) network to achieve its long-range service objectives for operational data transport to support the Space Station Freedom Program, the Earth Observing System, and other projects. NII is the Nascom ground communications network being developed to accommodate the operational traffic of the mid-1990s and beyond. The authors describe various baseline protocol architectures based on current and evolving technologies. They address the internetworking issues suggested for reliable transfer of data over heterogeneous segments. They also describe the NII architecture, topology, system components, and services. A comparative evaluation of the current and evolving technologies was made, and suggestions for further study are described. It is shown that the direction of the NII configuration and the subsystem component design will clearly depend on the advances made in the area of broadband integrated services.

  15. Test/analysis correlation and model updating of the STARS I II missile systems

    SciTech Connect

    Fulcher, C.W.; Marek, E.L.; Mayes, R.L.

    1992-01-01

    The testing, modeling, and test/analysis correlation of the STARS I II missile systems is reviewed. The STARS project is described. The system identification methodology is discussed. A series of modal tests designed to characterize the various structural components is summmarized. The development and updating of detailed finite element models, in a test/analysis correlation process, is presented.

  16. Educational Cost Analysis in Action: Case Studies for Planners -- II.

    ERIC Educational Resources Information Center

    Coombs, Philip H.; Hallak, Jacques

    This document is the second in a series of three documents, which together contain 27 case studies on the uses of cost analysis in educational planning. The case studies are presented to help planners and administrators see how cost analysis can be used to improve the efficiency of their educational systems, or to get the best value existing…

  17. Compatibility testing with anhydrous ammonia

    NASA Technical Reports Server (NTRS)

    Benner, Steve M.; Schweickart, Russell B.

    1992-01-01

    Anhydrous ammonia has been proposed as the working fluid for a number of two-phase thermal control systems to be used in future space applications, including the Space Station Freedom and the Earth Observing Station (EOS). The compatibility of ammonia with the components in these systems is a major concern due to the corrosive nature of the fluid. Compatibility of ammonia with stainless steel and some aluminum alloys is well documented; however, data on other materials potentially suitable for aerospace use is less common. This paper documents the compatibility testing of nine materials with both gaseous and liquid ammonia. The test procedures are presented along with the resulting measurement data. Tensile strength was the only mechanical property tested that indicated a significant material incompatibility.

  18. Spectroscopic, Elemental and Thermal Analysis, and Positron Annihilation Studies on Ca(II), Sr(II), Ba(II), Pb(II), and Fe(III) Penicillin G Potassium Complexes

    NASA Astrophysics Data System (ADS)

    Refat, M. S.; Sharshara, T.

    2015-11-01

    The [Pb(Pin)2] · 3H2O, [M(Pin)(H2O)2(Cl)] · nH2O (M = SrII, CaII or BaII; n = 0-1), and [Fe(Pin)2(Cl)(H2O)] · H2O penicillin G potassium (Pin) complexes were synthesized and characterized using elemental analyses, molar conductivity, thermal analysis and electronic spectroscopy techniques. The positron annihilation lifetime (PAL) and Doppler broadening (DB) techniques have been employed to probe the defects and structural changes of Pin ligand and its complexes. The PAL and DB line-shape parameters were discussed in terms of the structure, molecular weight, ligand-metal molar ratio, and other properties of the Pin complexes.

  19. Chemical compatibility of cartridge materials

    NASA Technical Reports Server (NTRS)

    Ambrose, Bryan; Wilcox, R. C.; Zee, R. H.

    1992-01-01

    The objectives were to determine the chemical compatibility of titanium-zirconium-molybdenum (TZM) with GaAs and CdZnTe, and Inconel with HgCdTe and HgZnTe. At the present time, no other studies regarding the compatibility of these crystal components and their respective cartridge materials have been performed. This study was to identify any possible problems between these materials to insure proper containment of possibly hazardous fumes during crystal growth experiments. In this study, the reaction zone between the materials was studied and the amount of degradation to the system was measured. Detailed results are presented.

  20. JAEA Fatigue Analysis of EBR-II Duplex Tubing

    SciTech Connect

    J. H. Jackson; D. L. Porter; W. R. Lloyd; N. Kisohara

    2011-03-01

    Small, notched three-point bend specimens machined from duplex tubes, which were extracted from an EBR-II superheater, were fatigued through the nickel interlayer to determine propensity for crack arrest within this interlayer. Several of these specimens were fatigued in the near threshold, and steady state regimes of Paris Law behavior. Additionally, two specimens were fatigued to the edge of the nickel interlayer and then monotonically loaded. Micro-hardness profiles of the nickel interlayer were also measured. Fatigue behavior was found to be similar to previous studies in that arrest was only noted in the near threshold Paris regime (attributed to the presence of voids) and in the steady state regime exhibited an acceleration of crack growth rate through the nickel interlayer followed by a slight retardation. Monotonic loading resulted in crack branching or delamination along the interlayer. Although archival material was not available for this study, the hardness of the nickel interlayer was determined to have been lowered slightly during service by comparison to the expected hardness of a similar nickel braze prepared as specified for fabrication of these tubes.

  1. Local structure analysis of some Cu(II) theophylline complexes

    NASA Astrophysics Data System (ADS)

    David, L.; Cozar, O.; Forizs, E.; Cr ăciun, C.; Ristoiu, D.; B ălan, C.

    1999-10-01

    The CuT 2L 2·2H 2O complexes [T=Theophylline (1,3-dimethylxanthine); L=NH 3, n-propylamine (npa), 2-aminoethanol (ae)] were prepared and investigated by ESR spectroscopy. Powder ESR spectrum of CuT 2(NH 3) 2·2H 2O is axial ( g||=2.255, g⊥=2.059). ESR spectrum of CuT 2(npa) 2·2H 2O with ( g||=2.299, g⊥=2.081) is a superposition of one axial ( g||=2.299, g⊥=2.073) and one isotropic component ( g0≈2.089), in the same amount. The axial spectra of the former complexes are due to a static Jahn-Teller effect ( EJT≈2880 cm -1). ESR spectrum of CuT 2(ae) 2·2H 2O is orthorhombic ( g1c=2.199, g2c=2.095, g3c=2.037). The local symmetries around the Cu(II) ions remain unchanged by DMF solvating, by adsorbing these solutions on NaY zeolite or by lowering the temperature.

  2. Quantitative analysis of topoisomerase II{alpha} to rapidly evaluate cell proliferation in brain tumors

    SciTech Connect

    Oda, Masashi; Arakawa, Yoshiki; Kano, Hideyuki; Kawabata, Yasuhiro; Katsuki, Takahisa; Shirahata, Mitsuaki; Ono, Makoto; Yamana, Norikazu; Hashimoto, Nobuo; Takahashi, Jun A. . E-mail: jat@kuhp.kyoto-u.ac.jp

    2005-06-17

    Immunohistochemical cell proliferation analyses have come into wide use for evaluation of tumor malignancy. Topoisomerase II{alpha} (topo II{alpha}), an essential nuclear enzyme, has been known to have cell cycle coupled expression. We here show the usefulness of quantitative analysis of topo II{alpha} mRNA to rapidly evaluate cell proliferation in brain tumors. A protocol to quantify topo II{alpha} mRNA was developed with a real-time RT-PCR. It took only 3 h to quantify from a specimen. A total of 28 brain tumors were analyzed, and the level of topo II{alpha} mRNA was significantly correlated with its immuno-staining index (p < 0.0001, r = 0.9077). Furthermore, it sharply detected that topo II{alpha} mRNA decreased in growth-inhibited glioma cell. These results support that topo II{alpha} mRNA may be a good and rapid indicator to evaluate cell proliferate potential in brain tumors.

  3. Detection and genetic analysis of group II capsules in Aeromonas hydrophila.

    PubMed

    Zhang, Y L; Lau, Y L; Arakawa, E; Leung, K Y

    2003-04-01

    The genetic organization and sequences of the group II capsule gene cluster of Aeromonas hydrophila PPD134/91 have been determined previously. The purified capsular polysaccharides can increase the ability of avirulent strain PPD35/85 to survive in naive tilapia serum but have no inhibitory effect on the adhesion of PPD134/91 to carp epithelial cells. In this study, the presence of group II capsules among 33 randomly chosen A. hydrophila strains was examined by electron microscopy and genetic analysis. Ten strains were found to produce group II capsules. A PCR detection system was developed to identify two types of group II capsules (IIA and IIB) based on their genetic organization in the region II gene clusters. Group IIA capsules in the authors' collection of A. hydrophila strains are mainly found in the O : 18 and O : 34 serogroups, while group IIB capsules are found in the O : 21 and O : 27 serogroups. The presence of group II capsules in A. hydrophila strongly correlates with the serum and phagocyte survival abilities (seven out of ten strains). The results indicate that the authors' PCR detection system can constitute a reliable assay for the classification of group II capsules in A. hydrophila. PMID:12686647

  4. Structural analysis of complexes formed by ethyl 4-phenylthiocarbamoyl piperazine-1-carboxylate with Ni(II), Zn(II) and Cd(II) through spectroscopic and DFT techniques

    NASA Astrophysics Data System (ADS)

    Prakash, Om; Gautam, Priyanka; Dani, R. K.; Nandi, Abhisikta; Singh, N. K.; Singh, Ranjan K.

    2014-04-01

    A piperazine derivative, ethyl 4-phenylthiocarbamoyl piperazine-1-carboxylate and its Ni(II), Zn(II) and Cd(II) complexes have been synthesized and characterized by elemental analyses, magnetic susceptibility measurement, UV-Visible, FTIR, Raman spectroscopic and DFT methods. The Ni(II) and Zn(II) bind through the N and S sites of the two ligand Heptpc and N site of two pyridine molecules. However, the Cd(II) binds through the only N sites of the two ligand Heptpc and N site of two pyridine molecules. On the basis of various techniques used for the characterizations of the complexes, we found that the most possible geometry of the Ni(II) and Zn(II) complexes are distorted octahedral and of the Cd(II) complex is distorted tetrahedral.

  5. Final Report: Posttest Analysis of Omega II Optical Specimens

    SciTech Connect

    Newlander, C D; Fisher, J H

    2007-01-30

    Preliminary posttest analyses have been completed on optical specimens exposed during the Omega II test series conducted on 14 July 2006. The Omega Facility, located at the Laboratory for Laser Energetics (LLE) at the University of Rochester was used to produce X-ray environments through the interaction of intense pulsed laser radiation upon germanium-loaded silica aerogels. The optical specimen testing was supported by GH Systems through experiment design, pre- and post-test analyses, specimen acquisition, and overall technical experience. The test specimens were fabricated and characterized by Surface Optics Corporation (SOC), San Diego, CA and were simple protected gold coatings on silica substrates. Six test specimens were exposed, five filtered with thin beryllium foil filters, and one unfiltered which was exposed directly to the raw environment. The experimental objectives were: (1) demonstrate that tests of optical specimens could be performed at the Omega facility; (2) evaluate the use and survivability of beryllium foil filters as a function of thickness; (3) obtain damage data on optical specimens which ranged from no damage to damage; (4) correlate existing thermal response models with the damage data; (5) evaluate the use of the direct raw environment upon the specimen response and the ability/desirability to conduct sensitive optical specimen tests using the raw environment; and (6) initiate the development of a protocol for performing optical coatings/mirror tests. This report documents the activities performed by GH Systems in evaluating and using the environments provided by LLNL, the PUFFTFT analyses performed using those environments, and the calculated results compared to the observed and measured posttest data.

  6. Activation analysis of the PULSAR-II fusion power reactor

    SciTech Connect

    Khater, H.Y.

    1995-12-31

    The PULSAR-II pulsed tokamak power plant design utilizes a blanket made of the vanadium alloy, V-5Cr-5Ti, and cooled with liquid lithium. The shield is made of a mixture of the low activation austenitic steel (Tenelon) and vanadium. The blanket is assumed to be replaced every 5.6 full power years (FPY) and the shield is assumed to stay in place for 30 FPY. The activity induced in the blanket at the end of its lifetime is higher than the activity induced in the shield after 30 FPY. At shutdown, the blanket and shield activities are 2678 MCi and 1747 MCi, respectively. One year after shutdown the shield activity drops to 18 MCi compared to 84 MCi for the blanket. The total decay heat generated in the blanket at the end of its lifetime is 34.7 MW and drops to 17.6 MW within an hour. At shutdown, 25.3 MW of decay heat are generated in the shield, dropping to only 0.1 MW within the first year. One week after shutdown, the values of the integrated decay heat are 1770 GJ for the blanket and 469 GJ for the shield. The radwaste classification of the reactor structure is evaluated according to both the NRC 10CFR61 and Fetter waste disposal concentration limits. After 5.6 years of irradiation, the blanket will only qualify for Class C low level waste. After 30 years of operation, the shield will also qualify for disposal as Class C waste. Only remote maintenance will be allowed inside the containment building.

  7. OPTICAL AND INFRARED ANALYSIS OF TYPE II SN 2006bc

    SciTech Connect

    Gallagher, Joseph S.; Sugerman, B. E. K.; Clayton, Geoffrey C.; Andrews, J. E.; Clem, J. E-mail: ben.sugerman@goucher.edu E-mail: jandrews@phys.lsu.edu; and others

    2012-07-10

    We present nebular phase optical imaging and spectroscopy and near/mid-IR imaging of the Type II SN 2006bc. Observations reveal the central wavelength of the symmetric H{alpha} line profile to be redshifted with respect to the host galaxy H{alpha} emission by day 325. Such a phenomenon has been argued to result from an asymmetric explosion in the iron-peak elements resulting in a larger mass of {sup 56}Ni and higher excitation of hydrogen on the far side of the supernova (SN) explosion. We also observe a gradual blueshifting of this H{alpha} peak which is indicative of dust formation in the ejecta. Although showing a normal peak brightness, V {approx} -17.2, for a core-collapse SN, 2006bc fades by {approx}6 mag during the first 400 days suggesting either a relatively low {sup 56}Ni yield, an increase in extinction due to new dust, or both. A short-duration flattening of the light curve is observed from day 416 to day 541 suggesting an optical light echo. Based on the narrow time window of this echo, we discuss implications on the location and geometry of the reflecting interstellar medium. With our radiative transfer models, we find an upper limit of 2 Multiplication-Sign 10{sup -3} M{sub Sun} of dust around SN 2006bc. In the event that all of this dust were formed during the SN explosion, this quantity of dust is still several orders of magnitude lower than that needed to explain the large quantities of dust observed in the early universe.

  8. Autistic Behavior, Behavior Analysis, and the Gene--Part II

    ERIC Educational Resources Information Center

    Malott, Richard W.

    2005-01-01

    This article reviews the negative behavior-analytic commentary on Drash and Tudor's behavior-analytic analysis of the etiology of autistic repertoires and values. This article also asks that, in our effort to scrub it clean, we not drown Drash and Tudor's beautiful, but fragile, new-born, behavior-analytic baby in hyper-methodological,…

  9. Harmonic analysis on local fields and adelic spaces. II

    NASA Astrophysics Data System (ADS)

    Osipov, Denis V.; Parshin, Aleksei N.

    2011-08-01

    We develop harmonic analysis in certain categories of filtered Abelian groups and vector spaces. The objects of these categories include local fields and adelic spaces arising from arithmetic surfaces. We prove some structure theorems for quotients of the adèle groups of algebraic and arithmetic surfaces.

  10. Topics in Finance: Part II--Financial Analysis

    ERIC Educational Resources Information Center

    Laux, Judy

    2010-01-01

    The second article in a series designed to supplement the introductory financial management course, this essay addresses financial statement analysis, including its impact on stock valuation, disclosure, and managerial behavior. [For "Topics in Finance Part I--Introduction and Stockholder Wealth Maximization," see EJ1060345.

  11. Rubber composition compatible with hydrazine

    NASA Technical Reports Server (NTRS)

    Repar, J.

    1973-01-01

    Formulation improves compatibility of butyl rubbers with hydrazine while reducing permeation to low levels necessary for prolonged storage in space. This is accomplished by replacing carbon-black filler with inert materials such as hydrated silica or clay. Pressure increases suggest that hydrazine is decomposed only slightly by new type of rubber.

  12. Atuarfitsialak: Greenland's Cultural Compatible Reform

    ERIC Educational Resources Information Center

    Wyatt, Tasha R.

    2012-01-01

    In 2002, Greenlandic reform leaders launched a comprehensive, nation-wide reform to create culturally compatible education. Greenland's reform work spans the entire educational system and includes preschool through higher education. To assist their efforts, reform leaders adopted the Standards for Effective Pedagogy developed at the Center for…

  13. Norelgestromin/ethinyl estradiol intravenous infusion formulation optimization, stability and compatibility testing: A case study to overcome polysorbate 80 interference in chromatographic analysis.

    PubMed

    Abdallah, Inas A; Hammell, Dana C; Hassan, Hazem E; Stinchcomb, Audra L

    2016-06-01

    Norelgestromin/ethinyl estradiol is a progestin/estrogen combination hormonal contraceptive indicated for the prevention of pregnancy in women. The very poor solubility and wettability of these drugs, along with their high potency (adsorption issues), give rise to difficulties in designing intravenous (IV) formulations to assess absolute bioavailability of products containing both drugs. The purpose of this study was to develop an IV formulation, evaluate its stability under different conditions and evaluate its compatibility with IV sets for potential use in absolute bioavailability studies in humans. Also, a selective high-performance liquid chromatography (HPLC) method for quantification of ethinyl estradiol and norelgestromin in polysorbate 80 matrix was developed and validated. Norelgestromin/ethinyl estradiol IV solution was prepared using sterile water for injection with 2.5% ethanol and 2.5% polysorbate 80 as a cosolvent/surfactant system to obtain a final drug solution of 25μg ethinyl estradiol and 252μg norelgestromin from a concentrated stock drug solution. The stabilities of the concentrated stock and IV solutions were assessed after storing them in the refrigerator (3.7±0.6°C) and at room temperature (19.5±0.5°C), respectively. Additional studies were conducted to examine the stability of the IV solution using an Alarias(®) low sorbing IV administration set with and without an inline filter. The solution was allowed to drip at 1mL/min over a 60min period. Samples were obtained at the beginning, middle and end of the 60min duration. The chemical stability was evaluated for up to 10 days. Norelgestromin and ethinyl estradiol concentration, purity, and degradant levels were determined using the HPLC method. The norelgestromin/ethinyl estradiol IV formulation met the chemical stability criteria when tested on day 1 through day 9 (216h). Norelgestromin concentrations assayed in stock and IV solutions were in the range of 90.0-98.5% and 90

  14. Random vibration analysis of the Topaz-II nuclear reactor power system. Master`s thesis

    SciTech Connect

    Campbell, S.E.

    1995-06-01

    The TOPAZ-II Ya-21U is one of six Russian made space nuclear power systems which is based on theomionic power conversion. The U.S. is presently analyzing TOPAZ-II to determine the reliability and feasibility of using this system. A structural analysis test was conducted on the TOPAZ unit in May 1993 to provide data from which modal parameters could be identified. This test showed the fundamental frequency to be 10.5 Hz, yet the test results that the Russians conducted identified a fundamental frequency of 5 Hz. Another finite element model was created incorporating new developments in TOPAZ-II and modifications to the finite element model to better simulate the mass properties of the TOPAZ-II2. A second structural analysis test was conducted on the TOPAZ unit 06-09 September 1994. This thesis focuses on the random vibration analysis of the TOPAZ-II Ya-2lU utilizing the most recent test results and the Master Series (updated version) I-DEAS software. The modal respose of the model and simulated random vibration tests were within 8.33%. This model is a feasible tool which can be used to analyze the TOPAZ unit without testing the unit to fatigue.

  15. Mars Surveyor Program '01 Mars Environmental Compatibility Assessment wet chemistry lab: a sensor array for chemical analysis of the Martian soil.

    PubMed

    Kounaves, Samuel P; Lukow, Stefan R; Comeau, Brian P; Hecht, Michael H; Grannan-Feldman, Sabrina M; Manatt, Ken; West, Steven J; Wen, Xiaowen; Frant, Martin; Gillette, Tim

    2003-07-25

    The Mars Environmental Compatibility Assessment (MECA) instrument was designed, built, and flight qualified for the now canceled MSP (Mars Surveyor Program) '01 Lander. The MECA package consisted of a microscope, electrometer, material patch plates, and a wet chemistry laboratory (WCL). The primary goal of MECA was to analyze the Martian soil (regolith) for possible hazards to future astronauts and to provide a better understanding of Martian regolith geochemistry. The purpose of the WCL was to analyze for a range of soluble ionic chemical species and electrochemical parameters. The heart of the WCL was a sensor array of electrochemically based ion-selective electrodes (ISE). After 20 months storage at -23 degrees C and subsequent extended freeze/thawing cycles, WCL sensors were evaluated to determine both their physical durability and analytical responses. A fractional factorial calibration of the sensors was used to obtain slope, intercept, and all necessary selectivity coefficients simultaneously for selected ISEs. This calibration was used to model five cation and three anion sensors. These data were subsequently used to determine concentrations of several ions in two soil leachate simulants (based on terrestrial seawater and hypothesized Mars brine) and four actual soil samples. The WCL results were compared to simulant and soil samples using ion chromatography and inductively coupled plasma optical emission spectroscopy. The results showed that flight qualification and prolonged low-temperature storage conditions had minimal effects on the sensors. In addition, the analytical optimization method provided quantitative and qualitative data that could be used to accurately identify the chemical composition of the simulants and soils. The WCL has the ability to provide data that can be used to "read" the chemical, geological, and climatic history of Mars, as well as the potential habitability of its regolith. PMID:14686320

  16. Genetic Analysis of the Aspergillus flavus Vegetative Compatibility Group to Which a Biological Control Agent That Limits Aflatoxin Contamination in U.S. Crops Belongs.

    PubMed

    Grubisha, Lisa C; Cotty, Peter J

    2015-09-01

    Some filamentous fungi in Aspergillus section Flavi produce carcinogenic secondary compounds called aflatoxins. Aflatoxin contamination is routinely managed in commercial agriculture with strains of Aspergillus flavus that do not produce aflatoxins. These non-aflatoxin-producing strains competitively exclude aflatoxin producers and reshape fungal communities so that strains with the aflatoxin-producing phenotype are less frequent. This study evaluated the genetic variation within naturally occurring atoxigenic A. flavus strains from the endemic vegetative compatibility group (VCG) YV36. AF36 is a strain of VCG YV36 and was the first fungus used in agriculture for aflatoxin management. Genetic analyses based on mating-type loci, 21 microsatellite loci, and a single nucleotide polymorphism (SNP) in the aflC gene were applied to a set of 237 YV36 isolates collected from 1990 through 2005 from desert legumes and untreated fields and from fields previously treated with AF36 across the southern United States. One haplotype dominated across time and space. No recombination with strains belonging to VCGs other than YV36 was detected. All YV36 isolates carried the SNP in aflC that prevents aflatoxin biosynthesis and the mat1-2 idiomorph at the mating-type locus. These results suggest that VCG YV36 has a clonal population structure maintained across both time and space. These results demonstrate the genetic stability of atoxigenic strains belonging to a broadly distributed endemic VCG in both untreated populations and populations where the short-term frequency of VCG YV36 has increased due to applications of a strain used to competitively exclude aflatoxin producers. This work supports the hypothesis that strains of this VCG are not involved in routine genetic exchange with aflatoxin-producing strains. PMID:26092465

  17. Mars Surveyor Program '01 Mars Environmental Compatibility Assessment wet chemistry lab: a sensor array for chemical analysis of the Martian soil

    NASA Technical Reports Server (NTRS)

    Kounaves, Samuel P.; Lukow, Stefan R.; Comeau, Brian P.; Hecht, Michael H.; Grannan-Feldman, Sabrina M.; Manatt, Ken; West, Steven J.; Wen, Xiaowen; Frant, Martin; Gillette, Tim

    2003-01-01

    The Mars Environmental Compatibility Assessment (MECA) instrument was designed, built, and flight qualified for the now canceled MSP (Mars Surveyor Program) '01 Lander. The MECA package consisted of a microscope, electrometer, material patch plates, and a wet chemistry laboratory (WCL). The primary goal of MECA was to analyze the Martian soil (regolith) for possible hazards to future astronauts and to provide a better understanding of Martian regolith geochemistry. The purpose of the WCL was to analyze for a range of soluble ionic chemical species and electrochemical parameters. The heart of the WCL was a sensor array of electrochemically based ion-selective electrodes (ISE). After 20 months storage at -23 degrees C and subsequent extended freeze/thawing cycles, WCL sensors were evaluated to determine both their physical durability and analytical responses. A fractional factorial calibration of the sensors was used to obtain slope, intercept, and all necessary selectivity coefficients simultaneously for selected ISEs. This calibration was used to model five cation and three anion sensors. These data were subsequently used to determine concentrations of several ions in two soil leachate simulants (based on terrestrial seawater and hypothesized Mars brine) and four actual soil samples. The WCL results were compared to simulant and soil samples using ion chromatography and inductively coupled plasma optical emission spectroscopy. The results showed that flight qualification and prolonged low-temperature storage conditions had minimal effects on the sensors. In addition, the analytical optimization method provided quantitative and qualitative data that could be used to accurately identify the chemical composition of the simulants and soils. The WCL has the ability to provide data that can be used to "read" the chemical, geological, and climatic history of Mars, as well as the potential habitability of its regolith.

  18. Mars Surveyor Program '01 Mars Environmental Compatibility Assessment wet chemistry lab: A sensor array for chemical analysis of the Martian soil

    NASA Astrophysics Data System (ADS)

    Kounaves, Samuel P.; Lukow, Stefan R.; Comeau, Brian P.; Hecht, Michael H.; Grannan-Feldman, Sabrina M.; Manatt, Ken; West, Steven J.; Wen, Xiaowen; Frant, Martin; Gillette, Tim

    2003-07-01

    The Mars Environmental Compatibility Assessment (MECA) instrument was designed, built, and flight qualified for the now canceled MSP (Mars Surveyor Program) '01 Lander. The MECA package consisted of a microscope, electrometer, material patch plates, and a wet chemistry laboratory (WCL). The primary goal of MECA was to analyze the Martian soil (regolith) for possible hazards to future astronauts and to provide a better understanding of Martian regolith geochemistry. The purpose of the WCL was to analyze for a range of soluble ionic chemical species and electrochemical parameters. The heart of the WCL was a sensor array of electrochemically based ion-selective electrodes (ISE). After 20 months storage at -23°C and subsequent extended freeze/thawing cycles, WCL sensors were evaluated to determine both their physical durability and analytical responses. A fractional factorial calibration of the sensors was used to obtain slope, intercept, and all necessary selectivity coefficients simultaneously for selected ISEs. This calibration was used to model five cation and three anion sensors. These data were subsequently used to determine concentrations of several ions in two soil leachate simulants (based on terrestrial seawater and hypothesized Mars brine) and four actual soil samples. The WCL results were compared to simulant and soil samples using ion chromatography and inductively coupled plasma optical emission spectroscopy. The results showed that flight qualification and prolonged low-temperature storage conditions had minimal effects on the sensors. In addition, the analytical optimization method provided quantitative and qualitative data that could be used to accurately identify the chemical composition of the simulants and soils. The WCL has the ability to provide data that can be used to ``read'' the chemical, geological, and climatic history of Mars, as well as the potential habitability of its regolith.

  19. Design and Analysis of CMOS-Compatible III-V Compound Electron-Hole Bilayer Tunneling Field-Effect Transistor for Ultra-Low-Power Applications.

    PubMed

    Kim, Sung Yoon; Seo, Jae Hwa; Yoon, Young Jun; Lee, Ho-Young; Lee, Seong Min; Cho, Seongjae; Kang, In Man

    2015-10-01

    In this work, we design and analyze complementary metal-oxide-semiconductor (CMOS)-compatible III-V compound electron-hole bilayer (EHB) tunneling field-effect transistors (TFETs) by using two-dimensional (2D) technology computer-aided design (TCAD) simulations. A recently proposed EHB TFET exploits a bias-induced band-to-band tunneling (BTBT) across the electron-hole bilayer by an electric field from the top and bottom gates. This is in contrast to conventional planar p(+)-p(-)-n TFETs, which utilize BTBT across the source-to-channel junction. We applied III-V compound semiconductor materials to the EHB TFETs in order to enhance the current drivability and switching performance. Devices based on various compound semiconductor materials have been designed and analyzed in terms of their primary DC characteristics. In addition, the operational principles were validated by close examination of the electron concentrations and energy-band diagrams under various operation conditions. The simulation results of the optimally designed In0.533Ga0.47As EHB TFET show outstanding performance, with an on-state current (Ion) of 249.5 μA/μm, subthreshold swing (S) of 11.4 mV/dec, and threshold voltage (Vth) of 50 mV at VDS = 0.5 V. Based on the DC-optimized InGaAs EHB TFET, the CMOS inverter circuit was simulated in views of static and dynamic behaviors of the p-channel device with exchanges between top and bottom gates or between source and drain electrodes maintaining the device structure. PMID:26726356

  20. Genetic Analysis of the Aspergillus flavus Vegetative Compatibility Group to Which a Biological Control Agent That Limits Aflatoxin Contamination in U.S. Crops Belongs

    PubMed Central

    Cotty, Peter J.

    2015-01-01

    Some filamentous fungi in Aspergillus section Flavi produce carcinogenic secondary compounds called aflatoxins. Aflatoxin contamination is routinely managed in commercial agriculture with strains of Aspergillus flavus that do not produce aflatoxins. These non-aflatoxin-producing strains competitively exclude aflatoxin producers and reshape fungal communities so that strains with the aflatoxin-producing phenotype are less frequent. This study evaluated the genetic variation within naturally occurring atoxigenic A. flavus strains from the endemic vegetative compatibility group (VCG) YV36. AF36 is a strain of VCG YV36 and was the first fungus used in agriculture for aflatoxin management. Genetic analyses based on mating-type loci, 21 microsatellite loci, and a single nucleotide polymorphism (SNP) in the aflC gene were applied to a set of 237 YV36 isolates collected from 1990 through 2005 from desert legumes and untreated fields and from fields previously treated with AF36 across the southern United States. One haplotype dominated across time and space. No recombination with strains belonging to VCGs other than YV36 was detected. All YV36 isolates carried the SNP in aflC that prevents aflatoxin biosynthesis and the mat1-2 idiomorph at the mating-type locus. These results suggest that VCG YV36 has a clonal population structure maintained across both time and space. These results demonstrate the genetic stability of atoxigenic strains belonging to a broadly distributed endemic VCG in both untreated populations and populations where the short-term frequency of VCG YV36 has increased due to applications of a strain used to competitively exclude aflatoxin producers. This work supports the hypothesis that strains of this VCG are not involved in routine genetic exchange with aflatoxin-producing strains. PMID:26092465

  1. Maximum Likelihood Analysis of Low Energy CDMS II Germanium Data

    SciTech Connect

    Agnese, R.

    2015-03-30

    We report on the results of a search for a Weakly Interacting Massive Particle (WIMP) signal in low-energy data of the Cryogenic Dark Matter Search experiment using a maximum likelihood analysis. A background model is constructed using GEANT4 to simulate the surface-event background from Pb210decay-chain events, while using independent calibration data to model the gamma background. Fitting this background model to the data results in no statistically significant WIMP component. In addition, we also perform fits using an analytic ad hoc background model proposed by Collar and Fields, who claimed to find a large excess of signal-like events in our data. Finally, we confirm the strong preference for a signal hypothesis in their analysis under these assumptions, but excesses are observed in both single- and multiple-scatter events, which implies the signal is not caused by WIMPs, but rather reflects the inadequacy of their background model.

  2. [Factorial analysis of the Hamilton depression scale, II].

    PubMed

    Dreyfus, J F; Guelfi, J D; Ruschel, S; Blanchard, C; Pichot, P

    1981-04-01

    A factorial analysis (principal components with Varimax rotation) was performed on 85 ratings of the Hamilton Depression Rating Scale obtained in 1979-1980 on inpatients with a major depressive illness. Using a replicable statistical technique, 4 factors were obtained. These factors do not overlap with those obtain on a similar sample with a similar technique nor with those obtained by other authors. It thus appears that there is no such thing as a factorial structure of this scale. PMID:7305179

  3. Variance analysis. Part II, The use of computers.

    PubMed

    Finkler, S A

    1991-09-01

    This is the second in a two-part series on variance analysis. In the first article (JONA, July/August 1991), the author discussed flexible budgeting, including the calculation of price, quantity, volume, and acuity variances. In this second article, the author focuses on the use of computers by nurse managers to aid in the process of calculating, understanding, and justifying variances. PMID:1919788

  4. Compatibility of technologies with regulations in the waste management of H-3, I-129, C-14, and Kr-85. Part II. Analysis

    SciTech Connect

    Trevorrow, L.E.; Kolba, V.M.; Vandegrift, G.F.; Steindler, M.J.

    1983-11-01

    Waste forms of /sup 3/H, /sup 129/I, /sup 14/C, and /sup 85/Kr separated from fuel reprocessing streams and procedures for managing them were analyzed regarding compliance with regulations. Transportation of these wastes in certain DOT-specification packagings would be permissible, but some of these packagings may not be acceptable in some disposal situations. Transportation of gaseous /sup 85/Kr in a currently certified cylinder is possible, but a fuel reprocessor may wish to ship larger quantities per package. Disposal of tritium using a package designed by a DOE contractor and shallow land burial, in accord with the regulations of 10 CFR 61, seems practicable. Although 10 CFR 61 permits shallow land burial of /sup 129/I, the concentration limit requires distribution in a volume that may seem impractical to commercial fuel reprocessors. The concentration limit of 10 CFR 61 for shallow land burial of /sup 14/C requires distribution in a lesser, although still large, volume. For both /sup 129/I and /sup 14/C, management as high-level waste offers the advantage of smaller volumes. Similar advantages may be offered by greater confinement or non-near surface concepts for disposal. The concrete waste forms developed for these nuclides may not meet technical criteria being formulated for geologic disposal. The lack of accommodation of /sup 85/Kr at disposal facilities makes storage of the gaseous form at the fuel reprocessing plant, followed by dispersal after partial decay, seem attractive. Ocean disposal of /sup 129/I and /sup 14/C by the rules of the International Atomic Energy Agency-London Ocean Dumping Convention offers advantages over shallow land burial: higher allowed concentrations, resulting in smaller volumes and fewer packages. These rules, however, thwart ocean disposal of /sup 85/Kr since gaseous forms are banned, and for solid forms, concentration limits would require distribution of radioactivity in very large volumes. 80 references.

  5. Compatibility and Kidney Transplantation: The Way to Go

    PubMed Central

    Doxiadis, Ilias I. N.

    2011-01-01

    Long lasting debates in the past questioned the relevance of any sort of compatibility in post mortal kidney transplantation. It is for no say that fully compatible transplants have the highest chances for a long patient and graft survival. In the present report the use of HLA-DR as a representative of the Major Histocompatibility Complex class II genes in the allocation of organs is discussed. The major arguments are the easiness to offer to patients a compatible graft in a relatively short waiting time, an increase in graft survival, the less sensitization during the transplantation period, and the lower waiting time for a retransplant. Even if the number of organ donors remains the same a lowering of the mean waiting time is expected because of the longer period of graft survival. PMID:22593759

  6. New advances in MR-compatible bioartificial liver

    PubMed Central

    Jeffries, Rex E.; Macdonald, Jeffrey M.

    2015-01-01

    MR-compatible bioartificial liver (BAL) studies have been performed for 30 years and are reviewed. There are two types of study: (i) metabolism and drug studies using multinuclear MRS; primarily short-term (< 8 h) studies; (ii) the use of multinuclear MRS and MRI to noninvasively define the features and functions of BAL systems for long-term liver tissue engineering. In the latter, these systems often undergo not only modification of the perfusion system, but also the construction of MR radiofrequency probes around the bioreactor. We present novel MR-compatible BALs and the use of multinuclear MRS (13C, 19F, 31P) for the noninvasive monitoring of their growth, metabolism and viability, as well as 1H MRI methods for the determination of flow profiles, diffusion, cell distribution, quality assurance and bioreactor integrity. Finally, a simple flexible coil design and circuit, and life support system, are described that can make almost any BAL MR-compatible. PMID:22351642

  7. Maximum Likelihood Analysis of Low Energy CDMS II Germanium Data

    DOE PAGESBeta

    Agnese, R.

    2015-03-30

    We report on the results of a search for a Weakly Interacting Massive Particle (WIMP) signal in low-energy data of the Cryogenic Dark Matter Search experiment using a maximum likelihood analysis. A background model is constructed using GEANT4 to simulate the surface-event background from Pb210decay-chain events, while using independent calibration data to model the gamma background. Fitting this background model to the data results in no statistically significant WIMP component. In addition, we also perform fits using an analytic ad hoc background model proposed by Collar and Fields, who claimed to find a large excess of signal-like events in ourmore » data. Finally, we confirm the strong preference for a signal hypothesis in their analysis under these assumptions, but excesses are observed in both single- and multiple-scatter events, which implies the signal is not caused by WIMPs, but rather reflects the inadequacy of their background model.« less

  8. Synthesis of Amphiphilic Ru(II) Heteroleptic Complexes Based on Benzo[1,2-b:4,5-b']dithiophene: Relevance of the Half-Sandwich Complex Intermediate and Solvent Compatibility.

    PubMed

    Urbani, Maxence; Medel, María; Kumar, Sangeeta Amit; Ince, Mine; Bhaskarwar, Ashok N; González-Rodríguez, David; Grätzel, Michael; Nazeeruddin, Mohammad Khaja; Torres, Tomás

    2015-11-01

    The detailed synthesis and characterization of four ruthenium(II) complexes [RuLL'(NCS)2 ] is reported, in which L represents a 2,2'-bipyridine ligand functionalized at the 4,4' positions with benzo[1,2-b:4,5-b']dithiophene derivatives (BDT) and L' is 2,2'-bipyridine-4,4'-dicarboxylic acid unit (dcbpy) (NCS=isothiocyanate). The reaction conditions were adapted and optimized for the preparation of these amphiphilic complexes with a strong lipophilic character. The photovoltaic performances of these complexes were tested in TiO2 dye-sensitized solar cell (DSSC) achieving efficiencies in the range of 3-4.5 % under simulated one sun illumination (AM1.5G). PMID:26359935

  9. Analysis of a model for the dynamics of prions II

    NASA Astrophysics Data System (ADS)

    Engler, Hans; Pruss, Jan; Webb, Glenn F.

    2006-12-01

    A new mathematical model for the dynamics of prion proliferation involving an ordinary differential equation coupled with a partial integro-differential equation is analyzed, continuing the work in [J. Pruss, L. Pujo-Menjouet, G.F. Webb, R. Zacher, Analysis of a model for the dynamics of prions, Discrete Contin. Dyn. Syst. 6 (2006) 225-235]. We show the well-posedness of this problem in its natural phase space , i.e., there is a unique global semiflow on Z+ associated to the problem. A theorem of threshold type is derived for this model which is typical for mathematical epidemics. If a certain combination of kinetic parameters is below or at the threshold, there is a unique steady state, the disease-free equilibrium, which is globally asymptotically stable in Z+; above the threshold it is unstable, and there is another unique steady state, the disease equilibrium, which inherits that property.

  10. Analysis and discrimination of electrical tapes: part II. Backings.

    PubMed

    Mehltretter, Andria H; Bradley, Maureen J; Wright, Diana M

    2011-11-01

    The backings of 90 black electrical tapes were analyzed to evaluate the chemical components of these films, the ability of individual techniques to discriminate samples, and the ability of the techniques combined to distinguish samples. The techniques utilized and their respective discrimination results were stereomicroscopy and physical measurements, to include observation of surface features of the backing, width, and thickness measurements (c. 64%); Fourier transform infrared spectroscopy (FTIR) using a microscope accessory (c. 83%); pyrolysis-gas chromatography/mass spectrometry (Py-GC/MS; c. 81%); and scanning electron microscopy/energy-dispersive spectroscopy (SEM/EDS; c. 87%). Ninety-four percent of the backings were discriminated through this combination of analytical methods. Finally, evaluating these results in conjunction with previously published data on the analysis of the adhesives from the same set of electrical tapes provided an overall discrimination of nearly 96%. PMID:21883209

  11. Difference Image Analysis of Galactic Microlensing. II. Microlensing Events

    SciTech Connect

    Alcock, C.; Allsman, R. A.; Alves, D.; Axelrod, T. S.; Becker, A. C.; Bennett, D. P.; Cook, K. H.; Drake, A. J.; Freeman, K. C.; Griest, K.

    1999-09-01

    The MACHO collaboration has been carrying out difference image analysis (DIA) since 1996 with the aim of increasing the sensitivity to the detection of gravitational microlensing. This is a preliminary report on the application of DIA to galactic bulge images in one field. We show how the DIA technique significantly increases the number of detected lensing events, by removing the positional dependence of traditional photometry schemes and lowering the microlensing event detection threshold. This technique, unlike PSF photometry, gives the unblended colors and positions of the microlensing source stars. We present a set of criteria for selecting microlensing events from objects discovered with this technique. The 16 pixel and classical microlensing events discovered with the DIA technique are presented. (c) (c) 1999. The American Astronomical Society.

  12. Randomizing world trade. II. A weighted network analysis

    NASA Astrophysics Data System (ADS)

    Squartini, Tiziano; Fagiolo, Giorgio; Garlaschelli, Diego

    2011-10-01

    Based on the misleading expectation that weighted network properties always offer a more complete description than purely topological ones, current economic models of the International Trade Network (ITN) generally aim at explaining local weighted properties, not local binary ones. Here we complement our analysis of the binary projections of the ITN by considering its weighted representations. We show that, unlike the binary case, all possible weighted representations of the ITN (directed and undirected, aggregated and disaggregated) cannot be traced back to local country-specific properties, which are therefore of limited informativeness. Our two papers show that traditional macroeconomic approaches systematically fail to capture the key properties of the ITN. In the binary case, they do not focus on the degree sequence and hence cannot characterize or replicate higher-order properties. In the weighted case, they generally focus on the strength sequence, but the knowledge of the latter is not enough in order to understand or reproduce indirect effects.

  13. Randomizing world trade. II. A weighted network analysis.

    PubMed

    Squartini, Tiziano; Fagiolo, Giorgio; Garlaschelli, Diego

    2011-10-01

    Based on the misleading expectation that weighted network properties always offer a more complete description than purely topological ones, current economic models of the International Trade Network (ITN) generally aim at explaining local weighted properties, not local binary ones. Here we complement our analysis of the binary projections of the ITN by considering its weighted representations. We show that, unlike the binary case, all possible weighted representations of the ITN (directed and undirected, aggregated and disaggregated) cannot be traced back to local country-specific properties, which are therefore of limited informativeness. Our two papers show that traditional macroeconomic approaches systematically fail to capture the key properties of the ITN. In the binary case, they do not focus on the degree sequence and hence cannot characterize or replicate higher-order properties. In the weighted case, they generally focus on the strength sequence, but the knowledge of the latter is not enough in order to understand or reproduce indirect effects. PMID:22181238

  14. Confirmatory Factor Analysis of the KABC-II in Preschool Children

    ERIC Educational Resources Information Center

    Morgan, Kimberly E.; Rothlisberg, Barbara A.; McIntosh, David E.; Hunt, Madeline S.

    2009-01-01

    The present study assessed the Kaufman Assessment Battery for Children, Second Edition (KABC-II) in relation to the synthesized Cattell-Horn-Carroll (CHC) theory of intelligence with a preschool sample. Participants were 200 preschool children between four and five years of age. A confirmatory factor analysis (CFA) was conducted, and different…

  15. A STANDARD PROCEDURE FOR COST ANALYSIS OF POLLUTION CONTROL OPERATIONS. VOLUME II. APPENDICES

    EPA Science Inventory

    Volume I is a user guide for a standard procedure for the engineering cost analysis of pollution abatement operations and processes. The procedure applies to projects in various economic sectors: private, regulated, and public. Volume II, the bulk of the document, contains 11 app...

  16. The Vineland-II in Preschool Children with Autism Spectrum Disorders: An Item Content Category Analysis

    ERIC Educational Resources Information Center

    Balboni, Giulia; Tasso, Alessandra; Muratori, Filippo; Cubelli, Roberto

    2016-01-01

    We investigated which item subsets of the Vineland-II can discriminate low-functioning preschoolers with ASD from matched peers with other neurodevelopmental disorders, using a regression analysis derived from a normative sample to account for cognitive and linguistic competencies. At variance with the typical profile, a pattern with Communication…

  17. Fault tree analysis of the EBR-II reactor shutdown system

    SciTech Connect

    Kamal, S.A.; Hill, D.J.

    1992-01-01

    As part of the level I Probabilistic Risk Assessment of the Experimental Breeder Reactor II (EBR-II), detailed fault trees for the reactor shutdown system are developed. Fault tree analysis is performed for two classes of transient events that are of particular importance to EBR-II operation: loss-of-flow and transient-overpower. In all parts of EBR-II reactor shutdown system, redundancy has been utilized in order to reduce scram failure probability. Therefore, heavy emphasis is placed in the fault trees on the common cause failures (CCFs) among similar mechanical components of the control and safety rods and among similar electrical components in redundant detection channels and shutdown strings. Generic beta-factors that cover all types of similar components and reflect redundancy level are used to model the CCFs. Human errors are addressed in the fault trees in two major areas: errors that would prevent the automatic scram channels from detecting the abnormal events and errors that would prevent utilization of the manual scram capability. The fault tree analysis of the EBR-II shutdown system has provided not only a systematic process for calculating the probabilities of system failures but also useful insights into the system and how its elements interact during transient events that require shutdown.

  18. Fault tree analysis of the EBR-II reactor shutdown system

    SciTech Connect

    Kamal, S.A.; Hill, D.J.

    1992-12-01

    As part of the level I Probabilistic Risk Assessment of the Experimental Breeder Reactor II (EBR-II), detailed fault trees for the reactor shutdown system are developed. Fault tree analysis is performed for two classes of transient events that are of particular importance to EBR-II operation: loss-of-flow and transient-overpower. In all parts of EBR-II reactor shutdown system, redundancy has been utilized in order to reduce scram failure probability. Therefore, heavy emphasis is placed in the fault trees on the common cause failures (CCFs) among similar mechanical components of the control and safety rods and among similar electrical components in redundant detection channels and shutdown strings. Generic beta-factors that cover all types of similar components and reflect redundancy level are used to model the CCFs. Human errors are addressed in the fault trees in two major areas: errors that would prevent the automatic scram channels from detecting the abnormal events and errors that would prevent utilization of the manual scram capability. The fault tree analysis of the EBR-II shutdown system has provided not only a systematic process for calculating the probabilities of system failures but also useful insights into the system and how its elements interact during transient events that require shutdown.

  19. Compatibility of Segments of Thermoelectric Generators

    NASA Technical Reports Server (NTRS)

    Snyder, G. Jeffrey; Ursell, Tristan

    2009-01-01

    A method of calculating (usually for the purpose of maximizing) the power-conversion efficiency of a segmented thermoelectric generator is based on equations derived from the fundamental equations of thermoelectricity. Because it is directly traceable to first principles, the method provides physical explanations in addition to predictions of phenomena involved in segmentation. In comparison with the finite-element method used heretofore to predict (without being able to explain) the behavior of a segmented thermoelectric generator, this method is much simpler to implement in practice: in particular, the efficiency of a segmented thermoelectric generator can be estimated by evaluating equations using only hand-held calculator with this method. In addition, the method provides for determination of cascading ratios. The concept of cascading is illustrated in the figure and the definition of the cascading ratio is defined in the figure caption. An important aspect of the method is its approach to the issue of compatibility among segments, in combination with introduction of the concept of compatibility within a segment. Prior approaches involved the use of only averaged material properties. Two materials in direct contact could be examined for compatibility with each other, but there was no general framework for analysis of compatibility. The present method establishes such a framework. The mathematical derivation of the method begins with the definition of reduced efficiency of a thermoelectric generator as the ratio between (1) its thermal-to-electric power-conversion efficiency and (2) its Carnot efficiency (the maximum efficiency theoretically attainable, given its hot- and cold-side temperatures). The derivation involves calculation of the reduced efficiency of a model thermoelectric generator for which the hot-side temperature is only infinitesimally greater than the cold-side temperature. The derivation includes consideration of the ratio (u) between the

  20. THE CARNEGIE-IRVINE GALAXY SURVEY. II. ISOPHOTAL ANALYSIS

    SciTech Connect

    Li Zhaoyu; Ho, Luis C.; Barth, Aaron J.; Peng, Chien Y.

    2011-12-01

    The Carnegie-Irvine Galaxy Survey (CGS) is a comprehensive investigation of the physical properties of a complete, representative sample of 605 bright (B{sub T} {<=} 12.9 mag) galaxies in the southern hemisphere. This contribution describes the isophotal analysis of the broadband (BVRI) optical imaging component of the project. We pay close attention to sky subtraction, which is particularly challenging for some of the large galaxies in our sample. Extensive crosschecks with internal and external data confirm that our calibration and sky subtraction techniques are robust with respect to the quoted measurement uncertainties. We present a uniform catalog of one-dimensional radial profiles of surface brightness and geometric parameters, as well as integrated colors and color gradients. Composite profiles highlight the tremendous diversity of brightness distributions found in disk galaxies and their dependence on Hubble type. A significant fraction of S0 and spiral galaxies exhibit non-exponential profiles in their outer regions. We perform Fourier decomposition of the isophotes to quantify non-axisymmetric deviations in the light distribution. We use the geometric parameters, in conjunction with the amplitude and phase of the m = 2 Fourier mode, to identify bars and quantify their size and strength. Spiral arm strengths are characterized using the m = 2 Fourier profiles and structure maps. Finally, we utilize the information encoded in the m = 1 Fourier profiles to measure disk lopsidedness. The databases assembled here and in Paper I lay the foundation for forthcoming scientific applications of CGS.

  1. Mars Hybrid Propulsion System Trajectory Analysis. Part II; Cargo Missions

    NASA Technical Reports Server (NTRS)

    Chai, Patrick R.; Merrill, Raymond G.; Qu, Min

    2015-01-01

    NASA's Human Spaceflight Architecture Team is developing a reusable hybrid transportation architecture in which both chemical and electric propulsion systems are used to send crew and cargo to Mars destinations such as Phobos, Deimos, the surface of Mars, and other orbits around Mars. By combining chemical and electrical propulsion into a single spaceship and applying each where it is more effective, the hybrid architecture enables a series of Mars trajectories that are more fuel-efficient than an all chemical architecture without significant increases in flight times. This paper shows the feasibility of the hybrid transportation architecture to pre-deploy cargo to Mars and Phobos in support of the Evolvable Mars Campaign crew missions. The analysis shows that the hybrid propulsion stage is able to deliver all of the current manifested payload to Phobos and Mars through the first three crew missions. The conjunction class trajectory also allows the hybrid propulsion stage to return to Earth in a timely fashion so it can be reused for additional cargo deployment. The 1,100 days total trip time allows the hybrid propulsion stage to deliver cargo to Mars every other Earth-Mars transit opportunity. For the first two Mars surface mission in the Evolvable Mars Campaign, the short trip time allows the hybrid propulsion stage to be reused for three round-trip journeys to Mars, which matches the hybrid propulsion stage's designed lifetime for three round-trip crew missions to the Martian sphere of influence.

  2. Project on restaurant energy performance: end-use monitoring and analysis. Appendixes I and II

    SciTech Connect

    Claar, C.N.; Mazzucchi, R.P.; Heidell, J.A.

    1985-05-01

    This is the second volume of the report, ''The Porject on Restaurant Energy Performance - End-Use Monitoring and Analysis''. The first volume (PNL-5462) contains a summary and analysis of the metered energy performance data collected by the Project on Restaurant Energy Performance (PREP). Appendix I, presented here, contains monitoring site descriptions, measurement plans, and data summaries for the seven restaurants metered for PREP. Appendix II, also in this volume, is a description of the PREP computer system.

  3. Stress analysis in oral obturator prostheses, part II: photoelastic imaging

    NASA Astrophysics Data System (ADS)

    Pesqueira, Aldiéris Alves; Goiato, Marcelo Coelho; da Silva, Emily Vivianne Freitas; Haddad, Marcela Filié; Moreno, Amália; Zahoui, Abbas; dos Santos, Daniela Micheline

    2014-06-01

    In part I of the study, two attachment systems [O-ring; bar-clip (BC)] were used, and the system with three individualized O-rings provided the lowest stress on the implants and the support tissues. Therefore, the aim of this study was to assess the stress distribution, through the photoelastic method, on implant-retained palatal obturator prostheses associated with different attachment systems: BOC-splinted implants with a bar connected to two centrally placed O-rings, and BOD-splinted implants with a BC connected to two distally placed O-rings (cantilever). One photoelastic model of the maxilla with oral-sinus-nasal communication with three parallel implants was fabricated. Afterward, two implant-retained palatal obturator prostheses with the two attachment systems described above were constructed. Each assembly was positioned in a circular polariscope and a 100-N axial load was applied in three different regions with implants by using a universal testing machine. The results were obtained through photograph record analysis of stress. The BOD system exhibited the highest stress concentration, followed by the BOC system. The O-ring, centrally placed on the bar, allows higher mobility of the prostheses and homogeneously distributes the stress to the region of the alveolar ridge and implants. It can be concluded that the use of implants with O-rings, isolated or connected with a bar, to rehabilitate maxillectomized patients allows higher prosthesis mobility and homogeneously distributes the stress to the alveolar ridge region, which may result in greater chewing stress distribution to implants and bone tissue. The clinical implication of the augmented bone support loss after maxillectomy is the increase of stress in the attachment systems and, consequently, a higher tendency for displacement of the prosthesis.

  4. Erythrocyte membrane analysis for type II diabetes detection using Raman spectroscopy in high-wavenumber region

    NASA Astrophysics Data System (ADS)

    Lin, Jinyong; Zeng, Yongyi; Lin, Juqiang; Wang, Jing; Li, Ling; Huang, Zufang; Li, Buhong; Zeng, Haishan; Chen, Rong

    2014-03-01

    Raman spectroscopy was employed to detect lipid variation occurring in type II diabetic erythrocyte membrane (EM) without using exogenous reagents. In high-wavenumber (HW) region, significant Raman spectral differences between diabetic and normal EM are observed at 2850, 2873, 2885, 2935, and 2965 cm-1, which are mainly related to lipid in EM. Based on principal component analysis, the diagnostic accuracy of HW region for diabetes detection is 98.8%, which is much higher than that of low-wavenumber region (82.9%). The results suggest that EM HW Raman region has great promise for the reagent-free and non-invasive detection of type II diabetes.

  5. Abundance analysis of roAp stars. II. HD 203932

    NASA Astrophysics Data System (ADS)

    Gelbmann, M.; Kupka, F.; Weiss, W. W.; Mathys, G.

    1997-03-01

    A new tool to simplify abundance analyses which is based on stand-alone programs has been applied to the rapidly oscillating Ap star HD 203932 (BI Mic, CD -30 18600, SAO 212996; Ap(SrEu), V=8.82mag). The spectroscopically determined T_eff_=7450+/-100K and logg=4.3+/-0.15 put this star close to the ZAMS. Other fundamental atmospheric parameters are v_micro_<0.6km/s and the total abundance of all iron peak elements [M/H]=0.0+/-0.1. The fundamental parameters put HD 203932 in a region of the HR-diagram where convection starts becoming efficient and the standard mixing length theory models lead to severe problems in the determination of the atmospheric parameters. The difference between the upper limit for logg obtained from several variants of the mixing length theory and the Canuto-Mazzitelli model indicates that the choice of a particular convection model can influence the determination of basic stellar parameters. For the first time abundances were determined for HD 203932 showing a pattern for the 35 investigated elements which is similar to α Cir (Kupka et al. 1996A&A...308..886K, Paper I). Fe and Ni have about solar abundance, Cr and especially Co are clearly overabundant as well as rare earth elements. The most underabundant element is Sc, followed by C, N, and O, which is a common property of CP2 stars. The lack of a correlation in our data between individual line abundances and their effective Lande factors implies a mean magnetic field modulus not exceeding few kG. Compared to the last homogeneous spectroscopic investigation of a large sample of chemically peculiar stars (21 cool Ap stars, Adelman 1973ApJ...183...95A), our analysis is based on data with higher spectral resolution and signal-to-noise ratio. Even more important, we are using a much larger atomic line data base with more precise atomic parameters than available more than twenty years ago.

  6. VizieR Online Data Catalog: The spectrum and term analysis of V II (Thorne+, 2013)

    NASA Astrophysics Data System (ADS)

    Thorne, A. P.; Pickering, J. C.; Semeniuk, J. I.

    2013-08-01

    The laboratory spectra used in this analysis were recorded with the f/25 vacuum UV Fourier transform (FT) spectrometer at Imperial College over the region 16000-67000cm-1 (6320-1500Å). The infrared spectra recorded for us with the FT spectrometer at the National Solar Observatory (NSO), Kitt Peak, Tucson, Arizona (Brault 1976JOSA...66.1081B), and used in the V I analysis as described in our previous paper (Thorne et al. 2011ApJS..192...11T), were included in the initial fitting, but almost all of the lines corresponding to possible V II transitions were doubly identified with strong V I transitions and therefore contributed very little to the V II analysis. (3 data files).

  7. Bioinformatic Analysis of Plasma Apolipoproteins A-I and A-II Revealed Unique Features of A-I/A-II HDL Particles in Human Plasma

    PubMed Central

    Kido, Toshimi; Kurata, Hideaki; Kondo, Kazuo; Itakura, Hiroshige; Okazaki, Mitsuyo; Urata, Takeyoshi; Yokoyama, Shinji

    2016-01-01

    Plasma concentration of apoA-I, apoA-II and apoA-II-unassociated apoA-I was analyzed in 314 Japanese subjects (177 males and 137 females), including one (male) homozygote and 37 (20 males and 17 females) heterozygotes of genetic CETP deficiency. ApoA-I unassociated with apoA-II markedly and linearly increased with HDL-cholesterol, while apoA-II increased only very slightly and the ratio of apoA-II-associated apoA-I to apoA-II stayed constant at 2 in molar ratio throughout the increase of HDL-cholesterol, among the wild type and heterozygous CETP deficiency. Thus, overall HDL concentration almost exclusively depends on HDL with apoA-I without apoA-II (LpAI) while concentration of HDL containing apoA-I and apoA-II (LpAI:AII) is constant having a fixed molar ratio of 2 : 1 regardless of total HDL and apoA-I concentration. Distribution of apoA-I between LpAI and LpAI:AII is consistent with a model of statistical partitioning regardless of sex and CETP genotype. The analysis also indicated that LpA-I accommodates on average 4 apoA-I molecules and has a clearance rate indistinguishable from LpAI:AII. Independent evidence indicated LpAI:A-II has a diameter 20% smaller than LpAI, consistent with a model having two apoA-I and one apoA-II. The functional contribution of these particles is to be investigated. PMID:27526664

  8. Bioinformatic Analysis of Plasma Apolipoproteins A-I and A-II Revealed Unique Features of A-I/A-II HDL Particles in Human Plasma.

    PubMed

    Kido, Toshimi; Kurata, Hideaki; Kondo, Kazuo; Itakura, Hiroshige; Okazaki, Mitsuyo; Urata, Takeyoshi; Yokoyama, Shinji

    2016-01-01

    Plasma concentration of apoA-I, apoA-II and apoA-II-unassociated apoA-I was analyzed in 314 Japanese subjects (177 males and 137 females), including one (male) homozygote and 37 (20 males and 17 females) heterozygotes of genetic CETP deficiency. ApoA-I unassociated with apoA-II markedly and linearly increased with HDL-cholesterol, while apoA-II increased only very slightly and the ratio of apoA-II-associated apoA-I to apoA-II stayed constant at 2 in molar ratio throughout the increase of HDL-cholesterol, among the wild type and heterozygous CETP deficiency. Thus, overall HDL concentration almost exclusively depends on HDL with apoA-I without apoA-II (LpAI) while concentration of HDL containing apoA-I and apoA-II (LpAI:AII) is constant having a fixed molar ratio of 2 : 1 regardless of total HDL and apoA-I concentration. Distribution of apoA-I between LpAI and LpAI:AII is consistent with a model of statistical partitioning regardless of sex and CETP genotype. The analysis also indicated that LpA-I accommodates on average 4 apoA-I molecules and has a clearance rate indistinguishable from LpAI:AII. Independent evidence indicated LpAI:A-II has a diameter 20% smaller than LpAI, consistent with a model having two apoA-I and one apoA-II. The functional contribution of these particles is to be investigated. PMID:27526664

  9. A population response analysis approach to assign class II HLA-epitope restrictions

    PubMed Central

    Arlehamn, Cecilia S. Lindestam; Huang, Huang; Davis, Mark M.; McKinney, Denise M.; Scriba, Thomas Jens; Sidney, John; Peters, Bjoern; Sette, Alessandro

    2015-01-01

    Identification of the specific HLA locus and allele presenting an epitope for recognition by specific T cell receptors (HLA restriction) is necessary to fully characterize the immune response to antigens. Experimental determination of HLA restriction is complex and technically challenging. As an alternative, the restricting HLA locus and allele can be inferred by genetic association, utilizing response data in an HLA typed population. However, simple odds ratio calculations can be problematic when dealing with large numbers of subjects and antigens and because the same epitope can be presented by multiple alleles (epitope promiscuity). Here, we develop a tool, denominated Restrictor Analysis Tool for Epitopes (RATE), to extract inferred restriction from HLA class II -typed epitope responses. This automated method infers HLA class II restriction from large datasets of T cell responses in HLA class II typed subjects by calculating Odds Ratios and relative frequencies from simple data tables. The program is validated by 1. Analyzing data of previously determined HLA restrictions. 2. Experimentally determining in selected individuals new HLA restrictions using HLA transfected cell lines 3. Predicting HLA restriction of particular peptides, and showing that corresponding HLA class II tetramers efficiently bind to epitope specific T cells. We further design a specific iterative algorithm to account for promiscuous recognition by calculation of Odds Ratio values for combinations of different HLA molecules while incorporating predicted HLA binding affinity. The RATE program streamlines the prediction of HLA class II restriction across multiple T cell epitopes and HLA types. PMID:25948811

  10. Constituting fully integrated visual analysis system for Cu(II) on TiO₂/cellulose paper.

    PubMed

    Li, Shun-Xing; Lin, Xiaofeng; Zheng, Feng-Ying; Liang, Wenjie; Zhong, Yanxue; Cai, Jiabai

    2014-07-15

    As a cheap and abundant porous material, cellulose filter paper was used to immobilize nano-TiO2 and denoted as TiO2/cellulose paper (TCP). With high adsorption capacity for Cu(II) (more than 1.65 mg), TCP was used as an adsorbent, photocatalyst, and colorimetric sensor at the same time. Under the optimum adsorption conditions, i.e., pH 6.5 and 25 °C, the adsorption ratio of Cu(II) was higher than 96.1%. Humic substances from the matrix could be enriched onto TCP but the interference of their colors on colorimetric detection could be eliminated by the photodegradation. In the presence of hydroxylamine, neocuproine, as a selective indicator, was added onto TCP, and a visual color change from white to orange was generated. The concentration of Cu(II) was quantified by the color intensity images using image processing software. This fully integrated visual analysis system was successfully applied for the detection of Cu(II) in 10.0 L of drinking water and seawater with a preconcentration factor of 10(4). The log-linear calibration curve for Cu(II) was in the range of 0.5-50.0 μg L(-1) with a determination coefficient (R(2)) of 0.985 and its detection limit was 0.073 μg L(-1). PMID:24942844

  11. What is a "DNA-Compatible" Reaction?

    PubMed

    Malone, Marie L; Paegel, Brian M

    2016-04-11

    DNA-encoded synthesis can generate vastly diverse screening libraries of arbitrarily complex molecules as long as chemical reaction conditions do not compromise DNA's informational integrity, a fundamental constraint that "DNA-compatible" reaction development does not presently address. We devised DNA-encoded reaction rehearsal, an integrated analysis of reaction yield and impact on DNA, to acquire these key missing data. Magnetic DNA-functionalized sensor beads quantitatively report the % DNA template molecules remaining viable for PCR amplification after exposure to test reaction conditions. Analysis of solid-phase bond forming (e.g., Suzuki-Miyaura cross-coupling, reductive amination) and deprotection reactions (e.g., allyl esters, silyl ethers) guided the definition and optimization of DNA-compatible reaction conditions (>90% yield, >30% viable DNA molecules), most notably in cases that involved known (H(+), Pd) and more obscure (Δ, DMF) hazards to DNA integrity. The data provide an empirical yet mechanistically consistent and predictive framework for designing successful DNA-encoded reaction sequences for combinatorial library synthesis. PMID:26971959

  12. Underground Test Area Subproject Phase I Data Analysis Task. Volume II - Potentiometric Data Document Package

    SciTech Connect

    1996-12-01

    Volume II of the documentation for the Phase I Data Analysis Task performed in support of the current Regional Flow Model, Transport Model, and Risk Assessment for the Nevada Test Site Underground Test Area Subproject contains the potentiometric data. Because of the size and complexity of the model area, a considerable quantity of data was collected and analyzed in support of the modeling efforts. The data analysis task was consequently broken into eight subtasks, and descriptions of each subtask's activities are contained in one of the eight volumes that comprise the Phase I Data Analysis Documentation.

  13. Design and calibration of a vacuum compatible scanning tunneling microscope

    NASA Technical Reports Server (NTRS)

    Abel, Phillip B.

    1990-01-01

    A vacuum compatible scanning tunneling microscope was designed and built, capable of imaging solid surfaces with atomic resolution. The single piezoelectric tube design is compact, and makes use of sample mounting stubs standard to a commercially available surface analysis system. Image collection and display is computer controlled, allowing storage of images for further analysis. Calibration results from atomic scale images are presented.

  14. Craniofacial analysis of the Tweed Foundation in Angle Class II, division 1 malocclusion.

    PubMed

    Tukasan, Paulo César; Magnani, Maria Beatriz Borges de Araújo; Nouer, Darcy Flávio; Nouer, Paulo Roberto Aranha; Neto, João Sarmento Pereira; Garbui, Ivana Uglik

    2005-01-01

    This study has defined the cephalometric values of the Craniofacial Analysis of the Tweed Foundation for a sample of Brazilian subjects. The sample consisted of 211 cephalometric radiographs from subjects aged 12-15, which were divided into two groups: Class II group, with 168 lateral teleradiographs (cephalograms) of white Brazilian subjects, with Angle Class II, division 1 malocclusion, of both genders (82 males and 86 females); and the Control Group, with 43 lateral teleradiographs (cephalograms) of subjects whose occlusion was clinically excellent, and also of both genders (21 males and 22 females). The teleradiographs were selected from the files of the Department of Orthodontics, School of Dentistry of Piracicaba, State University of Campinas, previously to the orthodontic treatment. The results demonstrated no sexual dimorphism for each group, as attested by the Student's t-test. The exploratory analysis (+/- 0.5 standard deviation) enabled the tolerance limits to be determined and a Craniofacial Analysis Table to be constructed using the respective cephalometric intervals. In addition, the difference between the two groups was not statistically significant according to the maxilla position. The maxilla was in a good position in relation to the cranial base. On the other hand, the mandible was retruded in relation to the cranial base in the Class II cases. The skeletal pattern was not defined because only the Facial Height Index (FHI) showed a vertical pattern in Class II subjects, while the Y Axis, SN.PlO, SN.GoMe and FMA values did not show any statistically significant difference between the groups. The Class II division 1 subjects showed lower incisors more labially tipped and a convex facial profile. PMID:16229360

  15. Compatible poliomyelitis cases in India during 2000.

    PubMed Central

    Kohler, Kathryn A.; Hlady, W. Gary; Banerjee, Kaushik; Gupta, Dhananjoy; Francis, Paul; Durrani, Sunita; Zuber, Patrick L. F.; Sutter, Roland W.

    2003-01-01

    OBJECTIVE: To describe the characteristics of compatible poliomyelitis cases and to assess the programmatic implications of clusters of such cases in India. METHODS: We described the characteristics of compatible poliomyelitis cases, identified clusters of compatible cases (two or more in the same district or neighbouring districts within two months), and examined their relationship to wild poliovirus cases. FINDINGS: There were 362 compatible cases in 2000. The incidence of compatible cases was higher in districts with laboratory-confirmed poliomyelitis cases than in districts without laboratory-confirmed cases. Of 580 districts, 96 reported one compatible case and 72 reported two or more compatible cases. Among these 168 districts with at least one compatible case, 123 had internal or cross- border clusters of compatible cases. In 27 districts with clusters of compatible cases, no wild poliovirus was isolated either in the same district or in neighbouring districts. Three of these 27 districts presented laboratory-confirmed poliomyelitis cases during 2001. CONCLUSION: Most clusters of compatible cases occurred in districts identified as areas with continuing wild poliovirus transmission and where mopping-up vaccination campaigns were carried out. As certification nears, areas with compatible poliomyelitis cases should be investigated and deficiencies in surveillance should be corrected in order to ensure that certification is justified. PMID:12640469

  16. Coproduction of detergent compatible bacterial enzymes and stain removal evaluation.

    PubMed

    Niyonzima, Francois N; More, Sunil S

    2015-10-01

    Most of the detergents that are presently produced contain the detergent compatible enzymes to improve and accelerate the washing performance by removing tough stains. The process is environment friendly as the use of enzymes in the detergent formulation reduces the utilization of toxic detergent constituents. The current trend is to use the detergent compatible enzymes that are active at low and ambient temperature in order to save energy and maintain fabric quality. As the detergent compatible bacterial enzymes are used together in the detergent formulation, it is important to co-produce the detergent enzymes in a single fermentation medium as the enzyme stability is assured, and production cost gets reduced enormously. The review reports on the production, purification, characterization and application of detergent compatible amylases, lipases, and proteases are available. However, there is no specific review or minireview on the concomitant production of detergent compatible amylases, lipases, and proteases. In this minireview, the coproduction of detergent compatible enzymes by bacterial species, enzyme stability towards detergents and detergent components, and stain release analysis were discussed. PMID:26011283

  17. A facile and fully automated on-fiber derivatization protocol for direct analysis of short-chain aliphatic amines using a matrix compatible solid-phase microextraction coating.

    PubMed

    Gionfriddo, Emanuela; Passarini, Alice; Pawliszyn, Janusz

    2016-07-29

    Solid-phase microextraction (SPME) analysis of short-chain aliphatic amines (C3-C6) in aqueous solutions was investigated using pentafluorobenzaldehyde (PFBAY) as on-fiber derivatization reagent. A standard gas generating vial agent was used for on-fiber loading of the derivatization agent so as to avoid the need for its regeneration at each derivatization cycle. Several parameters such as loading time, reaction temperature, and reaction/extraction time were optimized for headspace and direct sampling in aqueous solutions. Three different coating chemistries were tested and their performances compared in order to achieve the best compromise between sensitivity and analysis throughput. The newly developed PDMS/DVB/PDMS coating showed superior performance in terms of extraction efficiency while the capability to prevent on-fiber degradation of the derivatizing products. The optimized method was used for quantitation of short-chain aliphatic amines in aqueous samples and provided detection limits in the low ppb range for all the amines tested with accuracy values between 79 and 120%. The method was applied towards the analysis of environmental water samples and the accuracy of the results was evaluated by different calibration approaches. PMID:27371022

  18. Linear free-energy analysis of mercury(II) and cadmium(II) binding to three-stranded coiled coils.

    PubMed

    Ghosh, Debdip; Lee, Kyung-Hoon; Demeler, Borries; Pecoraro, Vincent L

    2005-08-01

    Investigators have studied how proteins enforce nonstandard geometries on metal centers to assess the question of how protein structures can define the coordination geometry and binding affinity of an active-site metal cofactor. We have shown that cysteine-substituted versions of the TRI peptide series [AcG-(LKALEEK)(4)G-NH(2)] bind Hg(II) and Cd(II) in geometries that are different from what is normally found with thiol ligands in aqueous solution. A fundamental question has been whether this structural perturbation is due to protein influence or a change in the metal geometry preference. To address this question, we have completed linear free-energy analyses that correlate the association of three-stranded coiled coils in the absence of a metal with the binding affinity of the peptides to the heavy metals, Hg(II) and Cd(II). In this paper, six new members of this family have been synthesized, replacing core leucine residues with smaller and less hydrophobic residues, consequently leading to varying degrees of self-association affinities. At the same time, studies with some smaller and longer sequenced peptides have also been examined. All of these peptides are seen to sequester Hg(II) and Cd(II) in an uncommon trigonal environment. For both metals, the binding is strong with micromolar dissociation constants. For binding of Hg(II) to the peptides, the dissociation constants range from 2.4 x 10(-)(5) M for Baby L12C to 2.5 x 10(-)(9) M for Grand L9C for binding of the third thiolate to a linear Hg(II)(pep)(2) species. The binding of Hg(II) to the peptide Grand L9C is similar in energetics for metal binding in the metalloregulatory protein, mercury responsive (merR), displaying approximately 50% trigonal Hg(II) formation at nanomolar metal concentrations. Approximately, 11 kcal/mol of the Hg(II)(Grand L9C)(3)(-) stability is due to peptide interactions, whereas only 1-4 kcal/mol stabilization results from Hg(II)(RS)(2) binding the third thiolate ligand. This

  19. EZ-FIT: a practical curve-fitting microcomputer program for the analysis of enzyme kinetic data on IBM-PC compatible computers.

    PubMed

    Perrella, F W

    1988-11-01

    EZ-FIT, an interactive microcomputer software package, has been developed for the analysis of enzyme kinetic and equilibrium binding data. EZ-FIT was designed as a user-friendly menu-driven package that has the facility for data entry, editing, and filing. Data input permits the conversion of cpm, dpm, or optical density to molar per minute per milligram protein. Data can be fit to any of 14 model equations including Michaelis-Menten, Hill, isoenzyme, inhibition, dual substrate, agonist, antagonist, and modified integrated Michaelis-Menten. The program uses the Nelder-Mead simplex and Marquardt nonlinear regression algorithms sequentially. A report of the results includes the parameter estimates with standard errors, a Student t test to determine the accuracy of the parameter values, a Runs statistic test of the residuals, identification of outlying data, an Akaike information criterion test for goodness-of-fit, and, when the experimental variance is included, a chi 2 statistic test for goodness-of-fit. Several different graphs can be displayed: an X-Y, a Scatchard, an Eadie-Hofstee, a Lineweaver-Burk, a semilogarithmic, and a residual plot. A data analysis report and graphs are designed to evaluate the goodness-of-fit of the data to a particular model. PMID:3239747

  20. Analysis of the Wakefield Effects in the PEP-II SLAC B-FACTORY

    SciTech Connect

    Novokhatski, A; Seeman, J.; Sullivan, M.; Wienands, U.; /SLAC

    2009-07-06

    We present the history and analysis of different wake field effects throughout the operational life of the PEP-II SLAC B-factory. Although the impedance of the high and low energy rings is small, the intense high current beams generated a lot of power. The effects from these wake fields are: heating and damage of vacuum beam chamber elements like RF seals, vacuum valves , shielded bellows, BPM buttons and ceramic tiles; vacuum spikes, vacuum instabilities and high detector background; beam longitudinal and transverse instabilities. We also discuss the methods used to eliminate these effects. Results of this analysis and the PEP-II experience may be very useful in the design of new storage rings and light sources.

  1. Serum albumin analysis for type II diabetes detection using surface-enhanced Raman spectroscopy

    NASA Astrophysics Data System (ADS)

    Lin, Jinyong; Cao, Gang; Lin, Juqiang; Liu, Nenrong; Liao, Fadian; Ruan, Qiuyong; Wu, Shanshan; Huang, Zufang; Li, Ling; Chen, Rong

    2014-09-01

    Surface-enhanced Raman scattering (SERS) spectroscopy combined with membrane electrophoresis (ME) was firstly employed to detect albumin variation in type II diabetic development. Albumin was first purified from human serum by ME and then mixed with silver nanoparticles to perform SERS spectral analysis. SERS spectra were obtained from blood albumin samples of 20 diabetic patients and 19 healthy volunteers. Subtle but discernible changes in the acquired mean spectra of the two groups were observed. Tentative assignment of albumin SERS bands indicated specific structural changes of albumin molecule with diabetic development. Meanwhile, PCA-LDA diagnostic algorithms were employed to classify the two kinds of albumin SERS spectra, yielding the diagnostic sensitivity of 90% and specificity of 94.7%. The results from this exploratory study demonstrated that the EM-SERS method in combination with multivariate statistical analysis has great potential for the label-free detection of albumin variation for improving type II diabetes screening.

  2. An optimized method for mycelial compatibility testing in Sclerotinia sclerotiorum.

    PubMed

    Schafer, Michelle R; Kohn, Linda M

    2006-01-01

    Classification of isolates into mycelial compatibility groups (MCGs) is used routinely in many laboratories as a quick marker for genotyping Sclerotinia sclerotiorum within populations. Scoring each new sample requires optimization of standardized conditions to support adequate growth of all paired isolates. Appropriate conditions for growth are especially important because diverse compatibility reactions are difficult to categorize and score (e.g., in samples from populations with high genetic diversity, such as those that receive immigration from genetically diverse sources or those that deviate from strict clonality). The current standard medium for MCG testing can be inhibitory to isolates from some samples, confounding scoring of compatibility. We identified two foci for optimization: (i) choice of medium, in this experiment, Patterson's medium amended with red food coloring (termed modified Patterson's medium, MPM, the current standard medium) versus potato dextrose agar (PDA) and (ii) amount of McCormick's red food coloring amended to the growth medium. The red food coloring often yields a red reaction line in incompatible interactions; alternative incompatible reactions are a line of thick or thin hyphae. Based on results to date, self-self pairings of S. sclerotiorum are compatible and are a reliable standard for scoring compatible self-nonself mycelial interactions. PDA amended with 75 microl/L of McCormick's red food coloring was identified as optimal for isolates inhibited by MPM from a highly diverse, recombining population sample. This precisely amended PDA was also suitable for isolates from highly clonal populations that were not inhibited by MPM or by higher concentrations of red food coloring. Under the optimized, standardized conditions all paired isolates grew together and produced interactions that could be scored in repeatedly identifiable categories, compatible or incompatible. Workers are advised to optimize conditions before screening a new

  3. The use of MAVIS II to integrate the modeling and analysis of explosive valve interactions

    SciTech Connect

    Ng, R.; Kwon, D.M.

    1998-12-31

    The MAVIS II computer program provides for the modeling and analysis of explosive valve interactions. This report describes the individual components of the program and how MAVIS II is used with other available tools to integrate the design and understanding of explosive valves. The rationale and model used for each valve interaction is described. Comparisons of the calculated results with available data have demonstrated the feasibility and accuracy of using MAVIS II for analytical studies of explosive valve interactions. The model used for the explosive or pyrotechnic used as the driving force in explosive valves is the most critical to be understood and modeled. MAVIS II is an advanced version that incorporates a plastic, as well as elastic, modeling of the deformations experienced when plungers are forced into a bore. The inclusion of a plastic model has greatly expanded the use of MAVIS for all categories (opening, closure, or combined) of valves, especially for the closure valves in which the sealing operation requires the plastic deformation of either a plunger or bore over a relatively large area. In order to increase its effectiveness, the use of MAVIS II should be integrated with the results from available experimental hardware. Test hardware such as the Velocity Interferometer System for Any Reflector (VISAR) and Velocity Generator test provide experimental data for accurate comparison of the actual valve functions. Variable Explosive Chamber (VEC) and Constant Explosive Volume (CEV) tests are used to provide the proper explosive equation-of-state for the MAVIS calculations of the explosive driving forces. The rationale and logistics of this integration is demonstrated through an example. A recent valve design is used to demonstrate how MAVIS II can be integrated with experimental tools to provide an understanding of the interactions in this valve.

  4. Detergent-compatible bacterial amylases.

    PubMed

    Niyonzima, Francois N; More, Sunil S

    2014-10-01

    Proteases, lipases, amylases, and cellulases are enzymes used in detergent formulation to improve the detergency. The amylases are specifically supplemented to the detergent to digest starchy stains. Most of the solid and liquid detergents that are currently manufactured contain alkaline enzymes. The advantages of using alkaline enzymes in the detergent formulation are that they aid in removing tough stains and the process is environmentally friendly since they reduce the use of toxic detergent ingredients. Amylases active at low temperature are preferred as the energy consumption gets reduced, and the whole process becomes cost-effective. Most microbial alkaline amylases are used as detergent ingredients. Various reviews report on the production, purification, characterization, and application of amylases in different industry sectors, but there is no specific review on bacterial or fungal alkaline amylases or detergent-compatible amylases. In this mini-review, an overview on the production and property studies of the detergent bacterial amylases is given, and the stability and compatibility of the alkaline bacterial amylases in the presence of the detergents and the detergent components are highlighted. PMID:25129040

  5. Compatibility of desoximetasone and tacrolimus.

    PubMed

    Levitt, Jacob; Feldman, Terry; Riss, Ildiko; Leung, On-Tai

    2003-12-01

    The physical and chemical compatibility of desoximetasone ointment 0.25% and tacrolimus ointment 0.1%, both widely used to treat atopic dermatitis, were determined. A 1:1 (w/w) mixture of desoximetasone ointment 0.25% (Topicort, Taro Pharmaceuticals USA, Inc.) and tacrolimus ointment 0.1% (Protopic, Fujisawa Healthcare, Inc.) were prepared and stored under three different temperature/relative humidity conditions: 25 degrees C/60% RH; 30 degrees C/60% RH; and 40 degrees C/75% RH. Unmixed ointments stored under the same temperature and humidity conditions as the mixture served as controls. Samples were evaluated at days 1, 2, 7, 14, and 28 for color, degree of physical separation, and chemical stability via reverse-phase high performance liquid chromatography. Ranges of relative recovery for each active ingredient for all storage conditions ((% Mixture/% Control) x 100) were 89.6-109.3% for tacrolimus and 99.0-103.4% for desoximetasone. No significant difference in physical appearance or chromatographic profile between the mixture and controls was observed. Therefore, we conclude that desoximetasone ointment 0.25% (Topicort) and tacrolimus ointment 0.1% (Protopic) are physically and chemically compatible up to four weeks when mixed in a ratio of 1:1 (w/w). PMID:14711143

  6. Is religious education compatible with science education?

    NASA Astrophysics Data System (ADS)

    Mahner, Martin; Bunge, Mario

    1996-04-01

    This paper tackles a highly controversial issue: the problem of the compatibility of science and religion, and its bearing on science and religious education respectively. We challenge the popular view that science and religion are compatible or even complementary. In order to do so, we give a brief characterization of our conceptions of science and religion. Conspicuous differences at the doctrinal, metaphysical, methodological and attitudinal level are noted. Regarding these aspects, closer examination reveals that science and religion are not only different but in fact incompatible. Some consequences of our analysis for education as well as for education policy are explored. We submit that a religious education, particularly at an early age, is an obstacle to the development of a scientific mentality. For this and other reasons, religious education should be kept away from public schools and universities. Instead of promoting a religious world view, we should teach our children what science knows about religion, i.e., how science explains the existence of religion in historical, biological, psychological and sociological terms.

  7. Automatic kelvin probe compatible with ultrahigh vacuum

    NASA Astrophysics Data System (ADS)

    Baikie, I. D.; van der Werf, K. O.; Oerbekke, H.; Broeze, J.; van Silfhout, A.

    1989-05-01

    This article describes a new type of in situ ultrahigh-vacuum compatible kelvin probe based on a voice-coil driving mechanism. This design exhibits several advantages over conventional mechanical feed-through and (in situ) piezoelectric devices in regard to the possibility of multiple probe geometry, flexibility of probe geometry, amplitude of oscillation, and pure parallel vibration. Automatic setup and constant spacing features are achieved using a digital-to-analog converter (DAC) steered offset potential. The combination of very low driver noise pick-up and data-acquisition system (DAS) signal processing techniques results in a work function (wf ) resolution, under optimal conditions, of <0.1 meV. Due to its high surface sensitivity and compatibility with standard sample cleaning and analysis techniques this design has numerous applications in surface studies, e.g., adsorption kinetics, sample topography and homogeneity, sputter profiles, etc. For semiconductor specimens the high wf resolution makes it eminently suitable for surface photovoltage (SPV) spectroscopy.

  8. Spectral characterization of V-type asteroids - II. A statistical analysis

    NASA Astrophysics Data System (ADS)

    Ieva, S.; Dotto, E.; Lazzaro, D.; Perna, D.; Fulvio, D.; Fulchignoni, M.

    2016-01-01

    In recent years, several small basaltic V-type asteroids have been identified all around the main belt. Most of them are members of the Vesta dynamical family, but an increasingly large number appear to have no link with it. The question that arises is whether all these basaltic objects do indeed come from Vesta. To find the answer to the above questioning, we decided to perform a statistical analysis of the spectroscopic and mineralogical properties of a large sample of V-types, with the objective to highlight similarities and differences among them, and shed light on their unique, or not, origin. The analysis was performed using 190 visible and near-infrared spectra from the literature for 117 V-type asteroids. The asteroids were grouped according to their dynamical properties and their computed spectral parameters compared. Comparison was also performed with spectral parameters of a sample of HED meteorites and data of the surface of Vesta taken by the VIR instrument on board of the Dawn spacecraft. Our analysis shows that although most of the V-type asteroids in the inner main belt do have a surface composition compatible with an origin from Vesta, this seem not to be the case for V-types in the middle and outer main belt.

  9. Full genome analysis of a novel type II feline coronavirus NTU156.

    PubMed

    Lin, Chao-Nan; Chang, Ruey-Yi; Su, Bi-Ling; Chueh, Ling-Ling

    2013-04-01

    Infections by type II feline coronaviruses (FCoVs) have been shown to be significantly correlated with fatal feline infectious peritonitis (FIP). Despite nearly six decades having passed since its first emergence, different studies have shown that type II FCoV represents only a small portion of the total FCoV seropositivity in cats; hence, there is very limited knowledge of the evolution of type II FCoV. To elucidate the correlation between viral emergence and FIP, a local isolate (NTU156) that was derived from a FIP cat was analyzed along with other worldwide strains. Containing an in-frame deletion of 442 nucleotides in open reading frame 3c, the complete genome size of NTU156 (28,897 nucleotides) appears to be the smallest among the known type II feline coronaviruses. Bootscan analysis revealed that NTU156 evolved from two crossover events between type I FCoV and canine coronavirus, with recombination sites located in the RNA-dependent RNA polymerase and M genes. With an exchange of nearly one-third of the genome with other members of alphacoronaviruses, the new emerging virus could gain new antigenicity, posing a threat to cats that either have been infected with a type I virus before or never have been infected with FCoV. PMID:23239278

  10. Analysis of Metric Type II Burst and EUV Waves Generated by Shock Wave Driven by Cme

    NASA Astrophysics Data System (ADS)

    Cunha-Silva, Rafael; Fernandes, Francisco; Selhorst, Caius

    2016-07-01

    The relationship between solar type II radio bursts produced by plasma oscillations and coronal shocks is well shown since the 1960s. However, the details of the association between the drivers of the shocks and the metric type II bursts remains a controversial issue. The flares and the coronal mass ejections (CMEs) are the potential drivers of these shocks. In this work, we present the analysis of a metric type II burst observed on May 17, 2013, by spectrometers from e-CALLISTO network and EUV images from the Extreme Ultraviolet Imager (EUVI), aboard the STEREO. The event was associated with an M3.2 X-ray flare and a halo CME. The EUV images show the EUV wave was produced by the expansion of the CME. The heights of the EUV wave fronts and the magnetic field intensity determined in the regions of the shock are consistent with those the heights of radio source obtained with the three-fold Newkirk density model, which suggests an oblique propagation of the shock. The finding of an accelerating shock with speed of 530-640 km/s and of 870-1220 km/s for the first and the second stages of the type II emission, respectively, is consistent with both the average speed of the associated EUV wave front, of 626 km/s, during the initial expansion of the CME, and with the linear speed of the CME, of 1345 km/s. These results will be presented and discussed.

  11. 77 FR 59702 - Promoting U.S. EC Regulatory Compatibility

    Federal Register 2010, 2011, 2012, 2013, 2014

    2012-09-28

    ... greater transatlantic regulatory compatibility generally. Concrete ideas on how greater compatibility.... We also invite you to share your concrete ideas on how greater compatibility could be achieved in...

  12. Level II scour analysis for bridge 2 (WODFTH00010002) on Town Highway 1, crossing Hell Hollow Brook, Woodford, Vermont

    USGS Publications Warehouse

    Burns, Ronda L.; Degnan, James R.

    1998-01-01

    This report provides the results of a detailed Level II analysis of scour potential at structure WODFTH00010002 on Town Highway 1 crossing Hell Hollow Brook, Woodford, Vermont (figures 1-8). A Level II study is a basic engineering analysis of the site, including a quantitative analysis of stream stability and scour (FHWA, 1993). Results of a Level I scour investigation also are included in appendix E of this report. A Level I investigation provides a qualitative geomorphic characterization of the study site. Information on the bridge, gleaned from Vermont Agency of Transportation (VTAOT) files, was compiled prior to conducting Level I and Level II analyses and is found in appendix D.

  13. Settlement-Compatible Lunar Transporation

    NASA Astrophysics Data System (ADS)

    Morgenthaler, G.

    Over the past few years we have published papers in this forum identifying, characterizing and advocating settlement-compatible transportation architectures for Mars. In the present paper, we do the same for the Moon and show evolutionary potentials for growth of lunar architectures into Mars architectures of the types discussed in our previous papers. The essence of a settlement-compatible architecture is that it yields a low recurring transportation cost and that the elements of the architecture are enduring, i.e., fully reusable with lifetimes on the order of Earth-based capital investments. Our previous papers have shown that extension of human habitation to other bodies in our Solar System is probably unaffordable with any other approach. The design of a settlement-compatible architecture begins with Earth launch. In our prior papers, we simply identified the Earth launch option as a fully reusable system with roughly Shuttle (or Atlas 5 or Delta 4 or Sea Launch or Ariane 5) capability, i.e. about 20 metric t. to low Earth orbit and a payload bay of dimensions about 5 m diameter x 15 to 20 m length. This is what the commercial market needs; this is where the traffic demand is; this is approximately the design point for a next-generation (after Shuttle) reusable launch vehicle. We continue in that vein for the present paper. Human mission advocates may argue it isn't big enough; that they need 80 metric t. payload to orbit. We answer that to achieve our cost criteria, there isn't much of a choice, and that the savings in launch cost will far outweigh the added expense for on-orbit assembly. Lunar transportation is considerably less demanding than Mars transportation. The main difference is in trip time. Because lunar trips are short, the crew habitat can be small, a la the Apollo Command Module, and the propulsion system to move it is also small by comparison. We analyze and depict a lunar transportation system based on crew elements adapted from the

  14. Ferroelastic dynamics and strain compatibility

    NASA Astrophysics Data System (ADS)

    Lookman, T.; Shenoy, S. R.; Rasmussen, K. Ø.; Saxena, A.; Bishop, A. R.

    2003-01-01

    We derive underdamped evolution equations for the order-parameter (OP) strains of a proper ferroelastic material undergoing a structural transition, using Lagrangian variations with Rayleigh dissipation, and a free energy as a polynomial expansion in the N=n+Nop symmetry-adapted strains. The Nop strain equations are structurally similar in form to the Lagrange-Rayleigh one-dimensional strain dynamics of Bales and Gooding (BG), with “strain accelerations” proportional to a Laplacian acting on a sum of the free-energy strain derivative and frictional strain force assuming geometric linearity. The tensorial St. Venant’s elastic compatibility constraints that forbid defects, are used to determine the n non-order-parameter strains in terms of the OP strains, generating anisotropic and long-range OP contributions to the free energy, friction, and noise. The same OP equations are obtained by either varying the displacement vector components, or by varying the N strains subject to the Nc compatibility constraints. A Fokker-Planck equation, based on the BG dynamics in more than one dimension with noise terms, is set up. The BG dynamics corresponds to a set of nonidentical nonlinear (strain) oscillators labeled by wave vector k→, with competing short- and long-range couplings. The oscillators have different “strain-mass” densities ρ(k)˜1/k2 and dampings ˜1/ρ(k)˜k2, so the lighter large-k oscillators equilibrate first, corresponding to earlier formation of smaller-scale oriented textures. This produces a sequential-scale scenario for post-quench nucleation, elastic patterning, and hierarchical growth. Neglecting inertial effects yields a late-time dynamics for identifying extremal free-energy states, that is, of the time-dependent Ginzburg-Landau form, with nonlocal, anisotropic Onsager coefficients that become constants for special parameter values. We consider in detail the two-dimensional (2D) unit-cell transitions from a triangular to a centered

  15. Genome-wide analysis of FOXO3 mediated transcription regulation through RNA polymerase II profiling.

    PubMed

    Eijkelenboom, Astrid; Mokry, Michal; de Wit, Elzo; Smits, Lydia M; Polderman, Paulien E; van Triest, Miranda H; van Boxtel, Ruben; Schulze, Almut; de Laat, Wouter; Cuppen, Edwin; Burgering, Boudewijn M T

    2013-01-01

    Forkhead box O (FOXO) transcription factors are key players in diverse cellular processes affecting tumorigenesis, stem cell maintenance and lifespan. To gain insight into the mechanisms of FOXO-regulated target gene expression, we studied genome-wide effects of FOXO3 activation. Profiling RNA polymerase II changes shows that FOXO3 regulates gene expression through transcription initiation. Correlative analysis of FOXO3 and RNA polymerase II ChIP-seq profiles demonstrates FOXO3 to act as a transcriptional activator. Furthermore, this analysis reveals a significant part of FOXO3 gene regulation proceeds through enhancer regions. FOXO3 binds to pre-existing enhancers and further activates these enhancers as shown by changes in histone acetylation and RNA polymerase II recruitment. In addition, FOXO3-mediated enhancer activation correlates with regulation of adjacent genes and pre-existence of chromatin loops between FOXO3 bound enhancers and target genes. Combined, our data elucidate how FOXOs regulate gene transcription and provide insight into mechanisms by which FOXOs can induce different gene expression programs depending on chromatin architecture. PMID:23340844

  16. TTF3 power coupler thermal analysis for LCLS-II CW operation

    SciTech Connect

    Xiao, L.; Adolphsen, C.; Li, Z.; Nantista, C.; Raubenheimer, T.; Solyak, N.; Gonin, I.

    2015-05-13

    The TESLA 9-cell SRF cavity design has been adopted for use in the LCLS-II SRF Linac. Its TTF3 coaxial fundamental power coupler (FPC), optimized for pulsed operation in European XFEL and ILC, requires modest changes to make it suitable for LCLS-II continuous-wave (CW) operation. For LCLS-II it must handle up to 7 kW of power, fully reflected, with the maximum temperature around 450 K, the coupler bake temperature. In order to improve TTF3 FPC cooling, an increased copper plating thickness will be used on the inner conductor of the ‘warm’ section of the coupler. Also, the antenna will be shortened to achieve higher cavity Qext values. Fully 3D FPC thermal analysis has been performed using the SLAC-developed parallel finite element code suite ACE3P, which includes electromagnetic codes and an integrated electromagnetic, thermal and mechanical multi-physics code. In this paper, we present TTF3 FPC thermal analysis simulation results obtained using ACE3P as well as a comparison with measurement results.

  17. Reevaluation of Stratospheric Ozone Trends From SAGE II Data Using a Simultaneous Temporal and Spatial Analysis

    NASA Technical Reports Server (NTRS)

    Damadeo, R. P.; Zawodny, J. M.; Thomason, L. W.

    2014-01-01

    This paper details a new method of regression for sparsely sampled data sets for use with time-series analysis, in particular the Stratospheric Aerosol and Gas Experiment (SAGE) II ozone data set. Non-uniform spatial, temporal, and diurnal sampling present in the data set result in biased values for the long-term trend if not accounted for. This new method is performed close to the native resolution of measurements and is a simultaneous temporal and spatial analysis that accounts for potential diurnal ozone variation. Results show biases, introduced by the way data is prepared for use with traditional methods, can be as high as 10%. Derived long-term changes show declines in ozone similar to other studies but very different trends in the presumed recovery period, with differences up to 2% per decade. The regression model allows for a variable turnaround time and reveals a hemispheric asymmetry in derived trends in the middle to upper stratosphere. Similar methodology is also applied to SAGE II aerosol optical depth data to create a new volcanic proxy that covers the SAGE II mission period. Ultimately this technique may be extensible towards the inclusion of multiple data sets without the need for homogenization.

  18. Reevaluation of stratospheric ozone trends from SAGE II data using a simultaneous temporal and spatial analysis

    NASA Astrophysics Data System (ADS)

    Damadeo, R. P.; Zawodny, J. M.; Thomason, L. W.

    2014-12-01

    This paper details a new method of regression for sparsely sampled data sets for use with time-series analysis, in particular the Stratospheric Aerosol and Gas Experiment (SAGE) II ozone data set. Non-uniform spatial, temporal, and diurnal sampling present in the data set result in biased values for the long-term trend if not accounted for. This new method is performed close to the native resolution of measurements and is a simultaneous temporal and spatial analysis that accounts for potential diurnal ozone variation. Results show biases, introduced by the way data are prepared for use with traditional methods, can be as high as 10%. Derived long-term changes show declines in ozone similar to other studies but very different trends in the presumed recovery period, with differences up to 2% per decade. The regression model allows for a variable turnaround time and reveals a hemispheric asymmetry in derived trends in the middle to upper stratosphere. Similar methodology is also applied to SAGE II aerosol optical depth data to create a new volcanic proxy that covers the SAGE II mission period. Ultimately this technique may be extensible towards the inclusion of multiple data sets without the need for homogenization.

  19. Reevaluation of stratospheric ozone trends from SAGE II data using a simultaneous temporal and spatial analysis

    NASA Astrophysics Data System (ADS)

    Damadeo, R. P.; Zawodny, J. M.; Thomason, L. W.

    2014-07-01

    This paper details a new method of regression for sparsely sampled data sets for use with time-series analysis, in particular the Stratospheric Aerosol and Gas Experiment (SAGE) II ozone data set. Non-uniform spatial, temporal, and diurnal sampling present in the data set result in biased values for the long-term trend if not accounted for. This new method is performed close to the native resolution of measurements and is a simultaneous temporal and spatial analysis that accounts for any potential diurnal variation. Results show declines in ozone similar to other studies but very different trends in the recovery period. The regression model allows for a variable turnaround time and reveals a~hemispheric asymmetry in the middle to upper stratosphere. Similar methodology is also applied to SAGE II aerosol optical depth data to create a new volcanic proxy that covers the SAGE II mission period. Ultimately this technique may be extensible towards the inclusion of multiple data sets without the need for homogenization.

  20. Electromagnetic compatibility in high-voltage engineering

    NASA Astrophysics Data System (ADS)

    Vanhouten, Marinus Albertus

    1990-09-01

    Electro Magnetic Compatibility (EMC) concepts for an efficient and consistant approach to practical interference problems are described. A critical analysis of 'grounding' is given. The design of a 'differentiated/integrated' system to measure fast voltage transients is described. Measurements of steep transient voltages across interruptions in a Gas Insulated Switchear (GIS) installation, due to switching actions, are presented. Available means to reduce the influence of this interference source on the measuring are discussed. General conclusions are that general, linear and basic design methods for the protection of electronics and (large) interconnected electrical systems against interference can be developed which can save production costs and research time. The design methods described concentrate on the reduction of dangerous voltages between critical points which can be achieved by correct layout choice.

  1. The Vineland-II in Preschool Children with Autism Spectrum Disorders: An Item Content Category Analysis.

    PubMed

    Balboni, Giulia; Tasso, Alessandra; Muratori, Filippo; Cubelli, Roberto

    2016-01-01

    We investigated which item subsets of the Vineland-II can discriminate low-functioning preschoolers with ASD from matched peers with other neurodevelopmental disorders, using a regression analysis derived from a normative sample to account for cognitive and linguistic competencies. At variance with the typical profile, a pattern with Communication more impaired than Socialization was observed. The source of the frequently reported Socialization delay in ASD appears to be in Playing and Imitating skills only, not in other social adaptive behavior skills. The combination of item subsets Playing, Following instructions, Beginning to talk, and Speech skills provided the best discrimination between the two clinical groups. Evaluation of the Vineland-II score on item content categories is a useful procedure for a more efficient clinical description. PMID:26210516

  2. Combined Analysis of Phase I and Phase II Data to Enhance the Power of Pharmacogenetic Tests

    PubMed Central

    Bertrand, J; Chenel, M; Comets, E

    2016-01-01

    We show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies. PK profiles were simulated under different designs along with 176 genetic markers. The null scenarios assumed no genetic effect, while under the alternative scenarios, drug clearance was associated with six genetic markers randomly sampled in each simulated dataset. We compared penalized regression Lasso and stepwise procedures to detect the associations between empirical Bayes estimates of clearance, estimated by nonlinear mixed effects models, and genetic variants. Combining data from phase I and phase II studies, even if sparse, increases the power to identify the associations between genetics and PK due to the larger sample size. Design optimization brings a further improvement, and we highlight a direct relationship between η‐shrinkage and loss of genetic signal. PMID:27069775

  3. NMR analysis of sequence of toxin II from the sea anemone Radianthus paumotensis

    SciTech Connect

    Wemmer, D.E.; Kumar, N.V.; Metrione, R.M.; Lazdunski, M.; Drobny, G.; Kallenbach, N.R.

    1986-11-04

    Toxin II from Radianthus paumotensis (Rp/sub II/) has been investigated by high-resolution NMR and chemical sequencing methods. Resonance assignments have been obtained for this protein by the sequential approach. NMR assignments could not be made consistent with the previously reported primary sequence for this protein, and chemical methods have been used to determine a sequence with which the NMR data are consistent. Analysis of the 2D NOE spectra shows that the protein secondary structure is comprised of two sequences of ..beta..-sheet, probably joined into a distorted continuous sheet, connected by turns and extended loops, without any regular ..cap alpha..-helical segments. The residues previously implicated in activity in this class of proteins, D8 and R13, occur in a loop region.

  4. (Analysis of cyanobacterial photosystem II genes by cloning and mutagenesis): Progress report

    SciTech Connect

    Not Available

    1988-01-01

    The major goal of this current proposal was to isolate, clone, sequence and mutagenize specific proteins associated with the photosynthetic membrane and photosystem II (PSII) in cyanobacteria. We have made great progress toward most of our goals and we have also gone off in some important new directions. The analysis of photosystem II proteins led us to investigate the growth of cyanobacteria under iron-deficient conditions and to detect a number of new proteins involved in the photosynthetic membrane. In addition, this work led us to isolate proteins that are localized in the cytoplasmic membrane or in the cell wall membrane. These studies have tremendously enriched our knowledge of membrane structure and, at the same time, have enabled us to probe cyanobacterial membranes with increased precision. 11 refs.

  5. Progress in accident analysis of the HYLIFE-II inertial fusion energy power plant design

    SciTech Connect

    Reyes, S; Latkowski, J F; Gomez del Rio, J; Sanz, J

    2000-10-11

    The present work continues our effort to perform an integrated safety analysis for the HYLIFE-II inertial fusion energy (IFE) power plant design. Recently we developed a base case for a severe accident scenario in order to calculate accident doses for HYLIFE-II. It consisted of a total loss of coolant accident (LOCA) in which all the liquid flibe (Li{sub 2}BeF{sub 4}) was lost at the beginning of the accident. Results showed that the off-site dose was below the limit given by the DOE Fusion Safety Standards for public protection in case of accident, and that his dose was dominated by the tritium released during the accident.

  6. Combined Analysis of Phase I and Phase II Data to Enhance the Power of Pharmacogenetic Tests.

    PubMed

    Tessier, A; Bertrand, J; Chenel, M; Comets, E

    2016-03-01

    We show through a simulation study how the joint analysis of data from phase I and phase II studies enhances the power of pharmacogenetic tests in pharmacokinetic (PK) studies. PK profiles were simulated under different designs along with 176 genetic markers. The null scenarios assumed no genetic effect, while under the alternative scenarios, drug clearance was associated with six genetic markers randomly sampled in each simulated dataset. We compared penalized regression Lasso and stepwise procedures to detect the associations between empirical Bayes estimates of clearance, estimated by nonlinear mixed effects models, and genetic variants. Combining data from phase I and phase II studies, even if sparse, increases the power to identify the associations between genetics and PK due to the larger sample size. Design optimization brings a further improvement, and we highlight a direct relationship between η-shrinkage and loss of genetic signal. PMID:27069775

  7. Results from a Low-Energy Analysis of the CDMS II Germanium Data

    SciTech Connect

    Ahmed, Z.; Akerib, D.S.; Arrenberg, S.; Bailey, C.N.; Balakishiyeva, D.; Baudis, L.; Bauer, D.A.; Brink, P.L.; Bruch, T.; Bunker, R.; Cabrera, B.; /Stanford U., Phys. Dept. /UC, Santa Barbara

    2010-11-01

    We report results from a reanalysis of data from the Cryogenic Dark Matter Search (CDMS II) experiment at the Soudan Underground Laboratory. Data taken between October 2006 and September 2008 using eight germanium detectors are reanalyzed with a lowered, 2 keV recoil-energy threshold, to give increased sensitivity to interactions from Weakly Interacting Massive Particles (WIMPs) with masses below {approx}10 GeV/c{sup 2}. This analysis provides stronger constraints than previous CDMS II results for WIMP masses below 9 GeV/c{sup 2} and excludes parameter space associated with possible low-mass WIMP signals from the DAMA/LIBRA and CoGeNT experiments.

  8. Campylobacter jejuni fatty acid synthase II: Structural and functional analysis of [beta]-hydroxyacyl-ACP dehydratase (FabZ)

    SciTech Connect

    Kirkpatrick, Andrew S.; Yokoyama, Takeshi; Choi, Kyoung-Jae; Yeo, Hye-Jeong

    2009-08-14

    Fatty acid biosynthesis is crucial for all living cells. In contrast to higher organisms, bacteria use a type II fatty acid synthase (FAS II) composed of a series of individual proteins, making FAS II enzymes excellent targets for antibiotics discovery. The {beta}-hydroxyacyl-ACP dehydratase (FabZ) catalyzes an essential step in the FAS II pathway. Here, we report the structure of Campylobacter jejuni FabZ (CjFabZ), showing a hexamer both in crystals and solution, with each protomer adopting the characteristic hot dog fold. Together with biochemical analysis of CjFabZ, we define the first functional FAS II enzyme from this pathogen, and provide a framework for investigation on roles of FAS II in C. jejuni virulence

  9. Subclassification of Recursive Partitioning Analysis Class II Patients With Brain Metastases Treated Radiosurgically

    SciTech Connect

    Yamamoto, Masaaki; Sato, Yasunori; Serizawa, Toru; Kawabe, Takuya; Higuchi, Yoshinori; Nagano, Osamu; Barfod, Bierta E.; Ono, Junichi; Kasuya, Hidetoshi; Urakawa, Yoichi

    2012-08-01

    Purpose: Although the recursive partitioning analysis (RPA) class is generally used for predicting survival periods of patients with brain metastases (METs), the majority of such patients are Class II and clinical factors vary quite widely within this category. This prompted us to divide RPA Class II patients into three subclasses. Methods and Materials: This was a two-institution, institutional review board-approved, retrospective cohort study using two databases: the Mito series (2,000 consecutive patients, comprising 787 women and 1,213 men; mean age, 65 years [range, 19-96 years]) and the Chiba series (1,753 patients, comprising 673 female and 1,080 male patients; mean age, 65 years [range, 7-94 years]). Both patient series underwent Gamma Knife radiosurgery alone, without whole-brain radiotherapy, for brain METs during the same 10-year period, July 1998 through June 2008. The Cox proportional hazard model with a step-wise selection procedure was used for multivariate analysis. Results: In the Mito series, four factors were identified as favoring longer survival: Karnofsky Performance Status (90% to 100% vs. 70% to 80%), tumor numbers (solitary vs. multiple), primary tumor status (controlled vs. not controlled), and non-brain METs (no vs. yes). This new index is the sum of scores (0 and 1) of these four factors: RPA Class II-a, score of 0 or 1; RPA Class II-b, score of 2; and RPA Class II-c, score of 3 or 4. Next, using the Chiba series, we tested whether our index is valid for a different patient group. This new system showed highly statistically significant differences among subclasses in both the Mito series and the Chiba series (p < 0.001 for all subclasses). In addition, this new index was confirmed to be applicable to Class II patients with four major primary tumor sites, that is, lung, breast, alimentary tract, and urogenital organs. Conclusions: Our new grading system should be considered when designing future clinical trials involving brain MET

  10. Advanced subsonic long-haul transport terminal area compatibility study. Volume 1: Compatibility assessment

    NASA Technical Reports Server (NTRS)

    1974-01-01

    An analysis was made to identify airplane research and technology necessary to ensure advanced transport aircraft the capability of accommodating forecast traffic without adverse impact on airport communities. Projections were made of the delay, noise, and emissions impact of future aircraft fleets on typical large urban airport. Design requirements, based on these projections, were developed for an advanced technology, long-haul, subsonic transport. A baseline aircraft was modified to fulfill the design requirements for terminal area compatibility. Technical and economic comparisons were made between these and other aircraft configured to support the study.

  11. Analysis of the Interaction of the Novel RNA Polymerase II (pol II) Subunit hsRPB4 with Its Partner hsRPB7 and with pol II

    PubMed Central

    Khazak, Vladimir; Estojak, Joanne; Cho, Helen; Majors, Jenifer; Sonoda, Gonosuke; Testa, Joseph R.; Golemis, Erica A.

    1998-01-01

    Under conditions of environmental stress, prokaryotes and lower eukaryotes such as the yeast Saccharomyces cerevisiae selectively utilize particular subunits of RNA polymerase II (pol II) to alter transcription to patterns favoring survival. In S. cerevisiae, a complex of two such subunits, RPB4 and RPB7, preferentially associates with pol II during stationary phase; of these two subunits, RPB4 is specifically required for survival under nonoptimal growth conditions. Previously, we have shown that RPB7 possesses an evolutionarily conserved human homolog, hsRPB7, which was capable of partially interacting with RPB4 and the yeast transcriptional apparatus. Using this as a probe in a two-hybrid screen, we have now established that hsRPB4 is also conserved in higher eukaryotes. In contrast to hsRPB7, hsRPB4 has diverged so that it no longer interacts with yeast RPB7, although it partially complements rpb4− phenotypes in yeast. However, hsRPB4 associates strongly and specifically with hsRPB7 when expressed in yeast or in mammalian cells and copurifies with intact pol II. hsRPB4 expression in humans parallels that of hsRPB7, supporting the idea that the two proteins may possess associated functions. Structure-function studies of hsRPB4-hsRPB7 are used to establish the interaction interface between the two proteins. This identification completes the set of human homologs for RNA pol II subunits defined in yeast and should provide the basis for subsequent structural and functional characterization of the pol II holoenzyme. PMID:9528765

  12. Biophysical Constraints and Ecological Compatibilities of Diverse Agroecosystems

    Technology Transfer Automated Retrieval System (TEKTRAN)

    A diagnostic approach based on multi-scale integrated analysis and model simulations was employed to identify specific or common biophysical constraints, technological changes and ecological compatibilities of the diverse subsistence and organic agro-ecosystems in the Fertile Crescent of West Asia a...

  13. Tank Farm Waste Transfer Compatibility Program

    SciTech Connect

    Fowler, K.D.

    1995-04-24

    The compatibility program described in this document formalizes the process for determining waste compatibility. Goal is to ensure that sufficient controls are in place to prevent the formation of incompatible mixtures during future operations, could possibly result in an unreviewed safety question. Waste transfer decision rules are presented as a process for assessing compatibility of wastes or waste mixtures. The process involves characterizing the waste comparing waste characteristics with the criteria, resolving potential incompatibilities, and documenting the process.

  14. Phylogenetic analysis of Pythium insidiosum Thai strains using cytochrome oxidase II (COX II) DNA coding sequences and internal transcribed spacer regions (ITS).

    PubMed

    Kammarnjesadakul, Patcharee; Palaga, Tanapat; Sritunyalucksana, Kallaya; Mendoza, Leonel; Krajaejun, Theerapong; Vanittanakom, Nongnuch; Tongchusak, Songsak; Denduangboripant, Jessada; Chindamporn, Ariya

    2011-04-01

    To investigate the phylogenetic relationship among Pythium insidiosum isolates in Thailand, we investigated the genomic DNA of 31 P. insidiosum strains isolated from humans and environmental sources from Thailand, and two from North and Central America. We used PCR to amplify the partial COX II DNA coding sequences and the ITS regions of these isolates. The nucleotide sequences of both amplicons were analyzed by the Bioedit program. Phylogenetic analysis using genetic distance method with Neighbor Joining (NJ) approach was performed using the MEGA4 software. Additional sequences of three other Pythium species, Phytophthora sojae and Lagenidium giganteum were employed as outgroups. The sizes of the COX II amplicons varied from 558-564 bp, whereas the ITS products varied from approximately 871-898 bp. Corrected sequence divergences with Kimura 2-parameter model calculated for the COX II and the ITS DNA sequences ranged between 0.0000-0.0608 and 0.0000-0.2832, respectively. Phylogenetic analysis using both the COX II and the ITS DNA sequences showed similar trees, where we found three sister groups (A(TH), B(TH), and C(TH)) among P. insidiosum strains. All Thai isolates from clinical cases and environmental sources were placed in two separated sister groups (B(TH) and C(TH)), whereas the Americas isolates were grouped into A(TH.) Although the phylogenetic tree based on both regions showed similar distribution, the COX II phylogenetic tree showed higher resolution than the one using the ITS sequences. Our study indicates that COX II gene is the better of the two alternatives to study the phylogenetic relationships among P. insidiosum strains. PMID:20818919

  15. Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading

    PubMed Central

    Hou, Tieying; Rinderknecht, Cornelia H; Hadjinicolaou, Andreas V; Busch, Robert; Mellins, Elizabeth

    2014-01-01

    Pulse-chase analysis is a commonly used technique for studying the synthesis, processing and transport of proteins. Cultured cells expressing proteins of interest are allowed to take up radioactively labeled amino acids for a brief interval (“pulse”), during which all newly synthesized proteins incorporate the label. The cells are then returned to non-radioactive culture medium for various times (“chase”), during which proteins may undergo conformational changes, trafficking, or degradation. Proteins of interest are isolated (usually by immunoprecipitation) and resolved by sodium dodecyl sulfate polyacrylamide gel electrophoresis (SDS-PAGE), and the fate of radiolabeled molecules is examined by autoradiography. This chapter describes a pulse-chase protocol suitable for studies of major histocompatibility complex (MHC) class II biosynthesis and maturation. We discuss how results are affected by the recognition by certain anti-class II antibodies of distinct class II conformations associated with particular biosynthetic states. Our protocol can be adapted to follow the fate of many other endogenously synthesized proteins, including viral or transfected gene products, in cultured cells. PMID:23329504

  16. Synthesis, Crystal structure, and Hirshfeld Surface Analysis of a New Mixed Ligand Copper(II) Complex.

    PubMed

    Shit, Shyamapada; Marschner, Christoph; Mitra, Samiran

    2016-01-01

    A new mixed ligand copper(II) complex, [Cu(2,4-pydc)(pic)(H(2)O)]∙H(2)O (1) (where 2,4-pydc = pyridine-2,4-dicarboxylate, pic = 2-picolylamine) has been synthesized and characterized by elemental analysis, FT-IR and UV-Vis spectroscopic and thermogravimetric methods. Single crystal X-ray diffraction analysis reveals that copper(II) atom in the title complex adopts distorted square pyramidal geometry. Structural characterization also reveals that interplay of O-H···O, N-H···O, C-H···O, and C-H···π interactions between lattice and coordinated water and ligands significantly contribute to the crystal packing leading to the formation and strengthening of three dimensional supramolecular assembly. Hirshfeld surface analysis employing 3D molecular surface contours and 2D fingerprint plots have been used to analyze intermolecular interactions present in the solid state of the crystal. PMID:26970797

  17. Analysis of C II resonance lines in some main sequence early-type stars

    NASA Technical Reports Server (NTRS)

    Cugier, H.; Hardorp, J.

    1988-01-01

    IUE data are used to investigate C II resonance lines at 1335 A in eight main-sequence stars of spectral types from A0 to B3, and both LTE and non-LTE line profiles have been computed. In stars with low rotational velocities (such as Vega, Pi Cet, and Tau Her), logarithmic carbon abundances log N(C/H) of -3.55 to -3.45 are obtained for the non-LTE case. The LTE analysis reveals lower carbon abundances by about 0.1 dex. Significant differences among the fast rotating stars are pointed out.

  18. Steady state thermal radiation analysis between the TOPAZ-II radiator and a heat exchanger

    SciTech Connect

    Maveety, J.G.; Wold, S.K.

    1995-12-31

    In this study the authors investigate the feasibility and efficiency of coupling a single-pass heat exchanger to the TOPAZ-II space power system operating at steady state conditions. A first and second law analysis was performed in order to determine the optimal operating conditions which minimize the pumping power and maximize the flow exergy of the working fluid. The results of this study show that (1) the space power system is basically unaffected by the addition of this heat exchanger and (2) as much as 60% of the availability is destroyed by irreversibilities while operating at optimal flow conditions.

  19. AIRE gene analysis in children with autoimmune hepatitis type I or II.

    PubMed

    Lankisch, Tim O; Mourier, Olivia; Sokal, Etienne M; Habes, Dalila; Lacaille, Florence; Bridoux-Henno, Laure; Hermeziu, Bogdan; Lenaerts, Catherine; Strassburg, Christian P; Jacquemin, Emmanuel

    2009-04-01

    The present report describes AIRE gene analysis in 25 children with autoimmune hepatitis type I or II. The heterozygous transversion c.961C > G (p.Ser278Arg) located in exon 7 was identified in 4 patients with autoimmune hepatitis type I, and mostly in those presenting with a positive family history for autoimmune diseases. In this subgroup of patients, the allelic frequency of this polymorphic variant was at least 3-fold higher than in healthy controls. These results suggest that heterozygous AIRE gene mutation may represent a genetic predisposition to childhood autoimmune hepatitis type I. PMID:19322061

  20. RE-ANALYSIS OF THE RADIO LUMINOSITY FUNCTION OF GALACTIC H II REGIONS

    SciTech Connect

    Paladini, R.; Noriega-Crespo, A.; Carey, S. J.; DeZotti, G.

    2009-09-10

    We have re-analyzed continuum and recombination lines radio data available in the literature in order to derive the luminosity function (LF) of Galactic H II regions. The study is performed by considering the first and fourth Galactic quadrants independently. We estimate the completeness level of the sample in the fourth quadrant at 5 Jy, and the one in the first quadrant at 2 Jy. We show that the two samples (fourth or first quadrant) include, as well as giant and supergiant H II regions, a significant number of subgiant sources. The LF is obtained, in each Galactic quadrant, with a generalized Schmidt's estimator using an effective volume derived from the observed spatial distribution of the considered H II regions. The re-analysis also takes advantage of recently published ancillary absorption data allowing to solve the distance ambiguity for several objects. A single power-law fit to the LFs retrieves a slope equal to -2.23 {+-} 0.07 (fourth quadrant) and to -1.85 {+-} 0.11 (first quadrant). We also find marginal evidence of a luminosity break at L{sub knee} = 10{sup 23.45} erg s{sup -1} Hz{sup -1} for the LF in the fourth quadrant. We convert radio luminosities into equivalent H{alpha} and Lyman continuum luminosities to facilitate comparisons with extragalactic studies. We obtain an average total H II regions Lyman continuum luminosity of 0.89 {+-} 0.23 x 10{sup 53} s{sup -1}, corresponding to 30% of the total ionizing luminosity of the Galaxy.

  1. HYDRA-II: A hydrothermal analysis computer code: Volume 3, Verification/validation assessments

    SciTech Connect

    McCann, R.A.; Lowery, P.S.

    1987-10-01

    HYDRA-II is a hydrothermal computer code capable of three-dimensional analysis of coupled conduction, convection, and thermal radiation problems. This code is especially appropriate for simulating the steady-state performance of spent fuel storage systems. The code has been evaluated for this application for the US Department of Energy's Commercial Spent Fuel Management Program. HYDRA-II provides a finite difference solution in cartesian coordinates to the equations governing the conservation of mass, momentum, and energy. A cylindrical coordinate system may also be used to enclose the cartesian coordinate system. This exterior coordinate system is useful for modeling cylindrical cask bodies. The difference equations for conservation of momentum are enhanced by the incorporation of directional porosities and permeabilities that aid in modeling solid structures whose dimensions may be smaller than the computational mesh. The equation for conservation of energy permits modeling of orthotropic physical properties and film resistances. Several automated procedures are available to model radiation transfer within enclosures and from fuel rod to fuel rod. The documentation of HYDRA-II is presented in three separate volumes. Volume I - Equations and Numerics describes the basic differential equations, illustrates how the difference equations are formulated, and gives the solution procedures employed. Volume II - User's Manual contains code flow charts, discusses the code structure, provides detailed instructions for preparing an input file, and illustrates the operation of the code by means of a model problem. This volume, Volume III - Verification/Validation Assessments, provides a comparison between the analytical solution and the numerical simulation for problems with a known solution. This volume also documents comparisons between the results of simulations of single- and multiassembly storage systems and actual experimental data. 11 refs., 55 figs., 13 tabs.

  2. Chemical analysis of carbon stars in the Local Group. II. The Carina dwarf spheroidal galaxy

    NASA Astrophysics Data System (ADS)

    Abia, C.; de Laverny, P.; Wahlin, R.

    2008-04-01

    Aims:We present new results of our ongoing chemical study of carbon stars in Local Group galaxies to test the critical dependence of s-process nucleosynthesis on the stellar metallicity. Methods: We collected optical spectra with the VLT/UVES instrument of two carbon stars found in the Carina Dwarf Spheroidal (dSph) galaxy, namely ALW-C6 and ALW-C7. We performed a full chemical analysis using the new generation of hydrostatic, spherically symmetric carbon-rich model atmospheres and the spectral synthesis method in LTE. Results: The luminosities, atmosphere parameters and chemical composition of ALW-C6 and ALW-C7 are compatible with these stars being in the TP-AGB phase undergoing third dredge-up episodes, although their extrinsic nature (external pollution in a binary stellar system) cannot be definitively excluded. Our chemical analysis shows that the metallicity of both stars agree with the average metallicity ([Fe/H] -1.8 dex) previously derived for this satellite galaxy from the analysis of both low resolution spectra of RGB stars and the observed colour magnitude diagrams. ALW-C6 and ALW-C7 present strong s-element enhancements, [ s/Fe] = +1.6, +1.5, respectively. These enhancements and the derived s-process indexes [ ls/Fe] , [ hs/Fe] and [ hs/ls] are compatible with theoretical s-process nucleosynthesis predictions in low mass AGB stars ( 1.5 M_⊙) on the basis that the 13C(α,n)16O is the main source of neutrons. Furthermore, the analysis of C2 and CN bands reveals a large carbon enhancement (C/O 7 and 5, respectively), much larger than the values typically found in galactic AGB carbon stars (C/O 1{-}2). This is also in agreement with the theoretical prediction that AGB carbon stars are formed more easily through third dredge-up episodes as the initial stellar metallicity drops. However, theoretical low-mass AGB models apparently fail to simultaneously fit the observed s-element and carbon enhancements. On the other hand, Zr is found to be less enhanced in

  3. 32 CFR 552.171 - Compatible use.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.171 Compatible use. (a) Military unit commanders may request during initial... 32 National Defense 3 2013-07-01 2013-07-01 false Compatible use. 552.171 Section 552.171...

  4. 32 CFR 552.95 - Compatible use.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.95 Compatible use. (a... 32 National Defense 3 2014-07-01 2014-07-01 false Compatible use. 552.95 Section 552.95 National... closed. (4) Motorized infantry operations that will use the majority of the road net in a training...

  5. 32 CFR 552.95 - Compatible use.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.95 Compatible use. (a... 32 National Defense 3 2013-07-01 2013-07-01 false Compatible use. 552.95 Section 552.95 National... closed. (4) Motorized infantry operations that will use the majority of the road net in a training...

  6. 32 CFR 552.171 - Compatible use.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.171 Compatible use. (a) Military unit commanders may request during initial... 32 National Defense 3 2012-07-01 2009-07-01 true Compatible use. 552.171 Section 552.171...

  7. 32 CFR 552.171 - Compatible use.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.171 Compatible use. (a) Military unit commanders may request during initial... 32 National Defense 3 2011-07-01 2009-07-01 true Compatible use. 552.171 Section 552.171...

  8. 32 CFR 552.95 - Compatible use.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.95 Compatible use. (a... 32 National Defense 3 2012-07-01 2009-07-01 true Compatible use. 552.95 Section 552.95 National... closed. (4) Motorized infantry operations that will use the majority of the road net in a training...

  9. 32 CFR 552.171 - Compatible use.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.171 Compatible use. (a) Military unit commanders may request during initial... 32 National Defense 3 2010-07-01 2010-07-01 true Compatible use. 552.171 Section 552.171...

  10. 32 CFR 552.171 - Compatible use.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Land Use Policy for Fort Lewis, Yakima Training Center, and Camp Bonneville § 552.171 Compatible use. (a) Military unit commanders may request during initial... 32 National Defense 3 2014-07-01 2014-07-01 false Compatible use. 552.171 Section 552.171...

  11. 32 CFR 552.95 - Compatible use.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.95 Compatible use. (a... 32 National Defense 3 2011-07-01 2009-07-01 true Compatible use. 552.95 Section 552.95 National... closed. (4) Motorized infantry operations that will use the majority of the road net in a training...

  12. 32 CFR 552.95 - Compatible use.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... CEMETERIES REGULATIONS AFFECTING MILITARY RESERVATIONS Fort Lewis Land Use Policy § 552.95 Compatible use. (a... 32 National Defense 3 2010-07-01 2010-07-01 true Compatible use. 552.95 Section 552.95 National... closed. (4) Motorized infantry operations that will use the majority of the road net in a training...

  13. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 36 Parks, Forests, and Public Property 3 2014-07-01 2014-07-01 false Compatibility. 1193.51 Section 1193.51 Parks, Forests, and Public Property ARCHITECTURAL AND TRANSPORTATION BARRIERS COMPLIANCE... Devices and Specialized Customer Premises Equipment § 1193.51 Compatibility. When required by subpart B...

  14. Tank Farm Waste Transfer Compatibility Program

    SciTech Connect

    FOWLER, K.D.

    2001-10-19

    The compatibility program described in this document formalizes the process for determining waste compatibility. The primary goal of the program is to ensure that sufficient controls are in place to prevent the formation of incompatible mixtures during future operations. The process described involves characterizing waste, comparing characteristics with criteria, resolving potential incompatibilities and documenting the process.

  15. Tank Farm Waste Transfer Compatibility Program

    SciTech Connect

    FOWLER, K.D.

    2000-07-12

    The compatibility program described in this document formalizes the process for determining waste compatibility. The primary goal of the program is to ensure that sufficient controls are in place to prevent the formation of incompatible mixtures during future operations. The process described involves characterizing waste, comparing characteristics with criteria, resolving potential incompatibilities and documenting the process.

  16. Driver Education Task Analysis. Volume II: Task Analysis Methods. Final Report.

    ERIC Educational Resources Information Center

    McKnight, A. James; Adams, Bert B.

    This report is the second in a series of four reports dealing with the development of performance-oriented driver education objectives and a set of measuring devices for evaluating attainment of the objectives. Included are descriptions of the analysis of driver's tasks and the evaluation of behavior criticality. During the analysis process, the…

  17. Analysis of SO II point source emissions using NASA atmospheric infrared sounder data

    NASA Astrophysics Data System (ADS)

    Shen, Sylvia S.; Miller, David P.; Lewis, Paul E.

    2007-04-01

    Determining the extent to which large power plant emission sources interacting with atmospheric constituents affect the environment could play a significant role in future U.S. energy production policy. The effects on the environment caused by the interaction between power plant emissions and atmospheric constituents has not been investigated in depth due to the lack of calibrated spectral data on a suitable temporal and spatial scale. The availability of NASA's space-based Atmospheric Infrared Sounder (AIRS) data makes it possible to explore, and begin the first steps toward establishing, a correlation between known emission sources and environmental indicators. An exploratory study was conducted in which a time series of 26 cloud-free AIRS data containing two coal-fired power plants in northern New Mexico were selected, acquired, and analyzed for SO II emissions. A generic forward modeling process was also developed to derive an estimate of the expected AIRS pixel radiance containing the SO II emissions from the two power plants based on published combustion analysis data for coal and available power plant documentation. Analysis of the AIRS NEΔR calculated in this study and subsequent comparison with the radiance values for SO II calculated from the forward model provided essential information regarding the suitability and risk in the use of a modified AIRS configuration for monitoring anthropogenic point source emissions. The results of this study along with its conclusions and recommendations in conjunction with additional research collaboration in several specific topics will provide guidance for the development of the next generation infrared spectrometer system that NASA is considering building for environmental monitoring.

  18. Genome-wide analysis of KAP1, the 7SK snRNP complex, and RNA polymerase II

    PubMed Central

    McNamara, Ryan P.; Guzman, Carlos; Reeder, Jonathan E.; D'Orso, Iván

    2016-01-01

    The transition of RNA polymerase II (Pol II) from transcription initiation into productive elongation in eukaryotic cells is regulated by the P-TEFb kinase, which phosphorylates the C-terminal domain of paused Pol II at promoter-proximal regions. Our recent study found that P-TEFb (in an inhibited state bound to the 7SK snRNP complex) interacts with the KAP1/TRIM28 transcriptional regulator, and that KAP1 and the 7SK snRNP co-occupy most gene promoters containing paused Pol II. Here we provide a detailed experimental description and analysis of the ChIP-seq datasets that have been deposited into Gene Expression Omnibus (GEO): GS72622, so that independent groups can replicate and expand upon these findings. We propose these datasets would provide valuable information for researchers studying mechanisms of transcriptional regulation including Pol II pausing and pause release. PMID:26981421

  19. Signal classification using global dynamical models, Part II: SONAR data analysis

    NASA Astrophysics Data System (ADS)

    Kremliovsky, Michael; Kadtke, James

    1996-06-01

    In Part I of this paper, we described a numerical method for nonlinear signal detection and classification which made use of techniques borrowed from dynamical systems theory. Here in Part II of the paper, we will describe an example of data analysis using this method, for data consisting of open ocean acoustic (SONAR) recordings of marine mammal transients, supplied from NUWC sources. The purpose here is two-fold: first to give a more operational description of the technique and provide rules-of-thumb for parameter choices; and second to discuss some new issues raised by the analysis of non-ideal (real-world) data sets. The particular data set considered here is quite non-stationary, relatively noisy, is not clearly localized in the background, and as such provides a difficult challenge for most detection/classification schemes.

  20. Analysis of safety limits of the Moroccan TRIGA MARK II research reactor

    NASA Astrophysics Data System (ADS)

    Erradi, L.; Essadki, H.

    2001-06-01

    The main objective of this study is to check the ability of the Moroccan TRIGA MARK II research reactor, designed to use natural convection cooling, to operate at its nominal power (2 MW) with sufficient safety margins. The neutronic analysis of the core has been performed using Leopard and Mcrac codes and the parameters of interest were the power distributions, the power peaking factors and the core excess reactivity. The thermal hydraulic analysis of the TRIGA core was performed using the French code FLICA designed for transient and study state situations. The main safety related parameters of the core have been evaluated with special emphasises on the following: maximum fuel temperature, minimum DNBR and maximum void fraction. The obtained results confirm the designer predictions except for the void fraction.

  1. Signal classification using global dynamical models, Part II: SONAR data analysis

    SciTech Connect

    Kremliovsky, M.; Kadtke, J.

    1996-06-01

    In Part I of this paper, we described a numerical method for nonlinear signal detection and classification which made use of techniques borrowed from dynamical systems theory. Here in Part II of the paper, we will describe an example of data analysis using this method, for data consisting of open ocean acoustic (SONAR) recordings of marine mammal transients, supplied from NUWC sources. The purpose here is two-fold: first to give a more operational description of the technique and provide rules-of-thumb for parameter choices; and second to discuss some new issues raised by the analysis of non-ideal (real-world) data sets. The particular data set considered here is quite non-stationary, relatively noisy, is not clearly localized in the background, and as such provides a difficult challenge for most detection/classification schemes. {copyright} {ital 1996 American Institute of Physics.}

  2. Advances in explosives analysis--part II: photon and neutron methods.

    PubMed

    Brown, Kathryn E; Greenfield, Margo T; McGrane, Shawn D; Moore, David S

    2016-01-01

    The number and capability of explosives detection and analysis methods have increased dramatically since publication of the Analytical and Bioanalytical Chemistry special issue devoted to Explosives Analysis [Moore DS, Goodpaster JV, Anal Bioanal Chem 395:245-246, 2009]. Here we review and critically evaluate the latest (the past five years) important advances in explosives detection, with details of the improvements over previous methods, and suggest possible avenues towards further advances in, e.g., stand-off distance, detection limit, selectivity, and penetration through camouflage or packaging. The review consists of two parts. Part I discussed methods based on animals, chemicals (including colorimetry, molecularly imprinted polymers, electrochemistry, and immunochemistry), ions (both ion-mobility spectrometry and mass spectrometry), and mechanical devices. This part, Part II, will review methods based on photons, from very energetic photons including X-rays and gamma rays down to the terahertz range, and neutrons. PMID:26446898

  3. Partial N-terminal sequence analysis of human class II molecules expressing the DQw3 determinant.

    PubMed

    Obata, F; Endo, T; Yoshii, M; Otani, F; Igarashi, M; Takenouchi, T; Ikeda, H; Ogasawara, K; Kasahara, M; Wakisaka, A

    1985-09-01

    HLA-DQ molecules were isolated from DRw9-homozygous and DR4-homozygous cell lines by using a monoclonal antibody HU-18, which recognizes class II molecules carrying the conventional DQw3 determinant. The partial N-terminal sequence analysis of the DQw3 molecules revealed that they have sequences homologous to those of murine I-A molecules. Within the limits of our sequence analysis, the DQw3 molecules from the two cell lines are identical to each other in both the alpha and beta chains. The DQ alpha as well as DQ beta chains were found to have amino acid substitutions when compared to other I-A-like molecules whose sequences have been reported. These differences may contribute to the DQw supertypic specificity. The polymorphic nature of DQ molecules is in marked contrast to that of DR molecules where DR alpha chains are highly conserved while DR beta chains have easily detectable amino acid substitutions. PMID:2411700

  4. Physics Metacognition Inventory Part II: Confirmatory factor analysis and Rasch analysis

    NASA Astrophysics Data System (ADS)

    Taasoobshirazi, Gita; Bailey, MarLynn; Farley, John

    2015-11-01

    The Physics Metacognition Inventory was developed to measure physics students' metacognition for problem solving. In one of our earlier studies, an exploratory factor analysis provided evidence of preliminary construct validity, revealing six components of students' metacognition when solving physics problems including knowledge of cognition, planning, monitoring, evaluation, debugging, and information management. The college students' scores on the inventory were found to be reliable and related to students' physics motivation and physics grade. However, the results of the exploratory factor analysis indicated that the questionnaire could be revised to improve its construct validity. The goal of this study was to revise the questionnaire and establish its construct validity through a confirmatory factor analysis. In addition, a Rasch analysis was applied to the data to better understand the psychometric properties of the inventory and to further evaluate the construct validity. Results indicated that the final, revised inventory is a valid, reliable, and efficient tool for assessing student metacognition for physics problem solving.

  5. neutron activation analysis using thermochromatography. II. thermochromatographic separation of elements in the analysis of geological samples

    SciTech Connect

    Sattarov, G.; Davydov, A.V.; Khamatov, S.; Kist, A.A.

    1986-07-01

    The use of gas thermochromatography (GTC) in the radioactivation analysis of difficulty soluble samples with a strongly activating substrate is discussed. The effect of sample coarseness and ore type on the rate of extraction of gold and accompanying elements was studied. The limits of detection of 22 elements were compared using neutron activation analysis with GTC and INAA. The analytical parameters of the procedure were estimated.

  6. RNA structure analysis using methidiumpropyl-EDTA.Fe(II): a base-pair-specific RNA structure probe.

    PubMed Central

    Vary, C P; Vournakis, J N

    1984-01-01

    Methidiumpropyl-EDTA.Fe(II) [MPE.Fe(II)] in the presence of dithiothreitol, is shown to cleave phenylalanine-accepting tRNA (tRNAPhe) in a structure-specific fashion. Molar ratios of MPE.Fe(II) to tRNAPhe of less than 1 preferentially cleave phosphodiester bonds known to occur in double-stranded regions of the tRNAPhe molecule. Microdensitometric analysis of autoradiograms of MPE.Fe(II) cleavage products following gel electrophoresis reveals a correspondence between preferred sites of MPE.Fe(II) cleavage and sites in tRNAPhe most sensitive to cobra venom ribonuclease, a double-strand-specific endoribonuclease. Conversely, sites of cleavage by the single-strand-specific S1 nuclease correspond to those nucleotides that are least susceptible to MPE.Fe(II) hydrolysis. Sensitive helical regions in tRNAPhe include the dihydrouracil and the "T psi C" stems, which cannot be detected by cobra venom ribonuclease because of steric constraints. Phosphodiester bonds within the T psi C and dihydrouracil loop regions, which are not detected by S1 nuclease under rigorously controlled digestion conditions, are revealed by inference from their relative insensitivity to MPE.Fe(II). These results demonstrate the utility of MPE.Fe(II) as a general small molecular weight probe of RNA structure, having a greater accessibility to base-paired regions than do the more bulky enzymic probes. Images PMID:6209709

  7. Water/sand flooded and immersed critical experiment and analysis performed in support of the TOPAZ-II Safety Program

    SciTech Connect

    Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Garin, V.P.; Gomin, E.A.; Kompanietz, G.V.; Krutoy, A.M.; Lobynstev, V.A.; Maiorov, L.V.; Polyakov, D.N.

    1994-11-01

    Presented is a brief description of the Narciss-M2 critical assemblies, which simulate accidental water/wet-sand immersion of the TOPAZ-II reactor as well as water-flooding of core cavities. Experimental results obtained from these critical assemblies, including experiments with several fuel elements removed from the core, are shown. These configurations with several extracted fuel elements simulate a proposed fuel-out anticriticality-device modification to the TOPAZ-II reactor. Preliminary computational analysis of these experiments using the Monte Carlo neutron-transport method is outlined. Nuclear criticality safety of the TOPAZ-II reactor with an incorporated anticriticality unit is demonstrated.

  8. Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding.

    PubMed

    Jones, Peter M; George, Anthony M

    2016-01-01

    MCoTI-I and II are plant defence proteins, potent trypsin inhibitors from the bitter gourd Momordica cochinchinensis. They are members of the Knottin Family, which display exceptional stability due to unique topology comprising three interlocked disulfide bridges. Knottins show promise as scaffolds for new drug development. A crystal structure of trypsin-bound MCoTI-II suggested that loop 1, which engages the trypsin active site, would show decreased dynamics in the bound state, an inference at odds with an NMR analysis of MCoTI-I, which revealed increased dynamics of loop 1 in the presence of trypsin. To investigate this question, we performed unrestrained MD simulations of trypsin-bound and free MCoTI-II. This analysis found that loop 1 of MCoTI-II is not more dynamic in the trypsin-bound state than in the free state. However, it revealed an intermediate conformation, transitional between the free and bound MCoTI-II states. The data suggest that MCoTI-II binding involves a process in which initial interaction with trypsin induces transitions between the free and intermediate conformations, and fluctuations between these states account for the increase in dynamics of loop 1 observed for trypsin-bound MCoTI-I. The MD analysis thus revealed new aspects of the inhibitors' dynamics that may be of utility in drug design. PMID:26975976

  9. Computational analysis of the MCoTI-II plant defence knottin reveals a novel intermediate conformation that facilitates trypsin binding

    PubMed Central

    Jones, Peter M.; George, Anthony M.

    2016-01-01

    MCoTI-I and II are plant defence proteins, potent trypsin inhibitors from the bitter gourd Momordica cochinchinensis. They are members of the Knottin Family, which display exceptional stability due to unique topology comprising three interlocked disulfide bridges. Knottins show promise as scaffolds for new drug development. A crystal structure of trypsin-bound MCoTI-II suggested that loop 1, which engages the trypsin active site, would show decreased dynamics in the bound state, an inference at odds with an NMR analysis of MCoTI-I, which revealed increased dynamics of loop 1 in the presence of trypsin. To investigate this question, we performed unrestrained MD simulations of trypsin-bound and free MCoTI-II. This analysis found that loop 1 of MCoTI-II is not more dynamic in the trypsin-bound state than in the free state. However, it revealed an intermediate conformation, transitional between the free and bound MCoTI-II states. The data suggest that MCoTI-II binding involves a process in which initial interaction with trypsin induces transitions between the free and intermediate conformations, and fluctuations between these states account for the increase in dynamics of loop 1 observed for trypsin-bound MCoTI-I. The MD analysis thus revealed new aspects of the inhibitors’ dynamics that may be of utility in drug design. PMID:26975976

  10. HYDRA-II: A hydrothermal analysis computer code: Volume 2, User's manual

    SciTech Connect

    McCann, R.A.; Lowery, P.S.; Lessor, D.L.

    1987-09-01

    HYDRA-II is a hydrothermal computer code capable of three-dimensional analysis of coupled conduction, convection, and thermal radiation problems. This code is especially appropriate for simulating the steady-state performance of spent fuel storage systems. The code has been evaluated for this application for the US Department of Energy's Commercial Spent Fuel Management Program. HYDRA-II provides a finite-difference solution in cartesian coordinates to the equations governing the conservation of mass, momentum, and energy. A cylindrical coordinate system may also be used to enclose the cartesian coordinate system. This exterior coordinate system is useful for modeling cylindrical cask bodies. The difference equations for conservation of momentum incorporate directional porosities and permeabilities that are available to model solid structures whose dimensions may be smaller than the computational mesh. The equation for conservation of energy permits modeling of orthotropic physical properties and film resistances. Several automated methods are available to model radiation transfer within enclosures and from fuel rod to fuel rod. The documentation of HYDRA-II is presented in three separate volumes. Volume 1 - Equations and Numerics describes the basic differential equations, illustrates how the difference equations are formulated, and gives the solution procedures employed. This volume, Volume 2 - User's Manual, contains code flow charts, discusses the code structure, provides detailed instructions for preparing an input file, and illustrates the operation of the code by means of a sample problem. The final volume, Volume 3 - Verification/Validation Assessments, provides a comparison between the analytical solution and the numerical simulation for problems with a known solution. 6 refs.

  11. Spectral energy distribution analysis of class I and class II FU Orionis stars

    SciTech Connect

    Gramajo, Luciana V.; Gómez, Mercedes; Rodón, Javier A. E-mail: mercedes@oac.uncor.edu

    2014-06-01

    FU Orionis stars (FUors) are eruptive pre-main sequence objects thought to represent quasi-periodic or recurring stages of enhanced accretion during the low-mass star-forming process. We characterize the sample of known and candidate FUors in a homogeneous and consistent way, deriving stellar and circumstellar parameters for each object. We emphasize the analysis in those parameters that are supposed to vary during the FUor stage. We modeled the spectral energy distributions of 24 of the 26 currently known FUors, using the radiative transfer code of Whitney et al. We compare our models with those obtained by Robitaille et al. for Taurus class II and I sources in quiescence periods by calculating the cumulative distribution of the different parameters. FUors have more massive disks: we find that ∼80% of the disks in FUors are more massive than any Taurus class II and I sources in the sample. Median values for the disk mass accretion rates are ∼10{sup –7} M {sub ☉} yr{sup –1} versus ∼10{sup –5} M {sub ☉} yr{sup –1} for standard young stellar objects (YSOs) and FUors, respectively. While the distributions of envelope mass accretion rates for class I FUors and standard class I objects are similar, FUors, on average, have higher envelope mass accretion rates than standard class II and class I sources. Most FUors (∼70%) have envelope mass accretion rates above 10{sup –7} M {sub ☉} yr{sup –1}. In contrast, 60% of the classical YSO sample has an accretion rate below this value. Our results support the current scenario in which changes experimented by the circumstellar disk explain the observed properties of these stars. However, the increase in the disk mass accretion rate is smaller than theoretically predicted, although in good agreement with previous determinations.

  12. Structural Analysis of the Rubisco-Assembly Chaperone RbcX-II from Chlamydomonas reinhardtii

    PubMed Central

    Liu, Cuimin; Hartl, F. Ulrich; Hayer-Hartl, Manajit

    2015-01-01

    The most prevalent form of the Rubisco enzyme is a complex of eight catalytic large subunits (RbcL) and eight regulatory small subunits (RbcS). Rubisco biogenesis depends on the assistance by specific molecular chaperones. The assembly chaperone RbcX stabilizes the RbcL subunits after folding by chaperonin and mediates their assembly to the RbcL8 core complex, from which RbcX is displaced by RbcS to form active holoenzyme. Two isoforms of RbcX are found in eukaryotes, RbcX-I, which is more closely related to cyanobacterial RbcX, and the more distant RbcX-II. The green algae Chlamydomonas reinhardtii contains only RbcX-II isoforms, CrRbcX-IIa and CrRbcX-IIb. Here we solved the crystal structure of CrRbcX-IIa and show that it forms an arc-shaped dimer with a central hydrophobic cleft for binding the C-terminal sequence of RbcL. Like other RbcX proteins, CrRbcX-IIa supports the assembly of cyanobacterial Rubisco in vitro, albeit with reduced activity relative to cyanobacterial RbcX-I. Structural analysis of a fusion protein of CrRbcX-IIa and the C-terminal peptide of RbcL suggests that the peptide binding mode of RbcX-II may differ from that of cyanobacterial RbcX. RbcX homologs appear to have adapted to their cognate Rubisco clients as a result of co-evolution. PMID:26305355

  13. Waste compatibility safety issues and final results for tank 241-SY-102 grab samples

    SciTech Connect

    Nuzum, J.L.

    1997-08-14

    Three grab samples (2SY-96-1, 2SY-96-2, and 2SY-96-3) were taken from Riser 1A of Tank 241-SY 102 on January 14, 1997, and received by 222-S Laboratory on January 14, 1997. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farm Waste Compatibility Program (DQO) in support of the Waste Compatibility Program. No notifications were required based on sample results. Acetone analysis was not performed in accordance with Cancellation of Acetone Analysis for Tank 241-SY-102 Grab Samples.

  14. Physics Metacognition Inventory Part Ii: Confirmatory Factor Analysis and Rasch Analysis

    ERIC Educational Resources Information Center

    Taasoobshirazi, Gita; Bailey, MarLynn; Farley, John

    2015-01-01

    The Physics Metacognition Inventory was developed to measure physics students' metacognition for problem solving. In one of our earlier studies, an exploratory factor analysis provided evidence of preliminary construct validity, revealing six components of students' metacognition when solving physics problems including knowledge of cognition,…

  15. An analysis of electrical and optical characteristics of a type II superlattice for optical switching applications

    NASA Astrophysics Data System (ADS)

    Rahman, M.; Rouf, A. S. M. S.; Mohammedy, F. M.

    2015-06-01

    The present work demonstrates an analysis of electronic and optical characteristics of InAs/GaSbType II superlattice based photodetectors. The electronic characteristics are analyzed by developing a model of the Type II superlattice. The 8 band k.p method is implemented to deduce the wavefunctions. The effects of temperature on zero-bias resistance- area product (R0A) are also included in the model. The newly proposed M-Structure design method is also implemented for our model. Electrical and optical properties of the material such as dark current density and absorption coefficient are calculated. At 50mV reverse bias, the dark current density is found equal to 1.5×10-4 A/cm2. These calculations are done based on the approximation based models of reflectivity. These results were used to demonstrate the variation of optical properties with applied bias voltage to be used as a novel optical switching technique in WDM based communication networks.

  16. The Tracking Meteogram, an AWIPS II Tool for Time-Series Analysis

    NASA Technical Reports Server (NTRS)

    Burks, Jason Eric; Sperow, Ken

    2015-01-01

    A new tool has been developed for the National Weather Service (NWS) Advanced Weather Interactive Processing System (AWIPS) II through collaboration between NASA's Short-term Prediction Research and Transition (SPoRT) and the NWS Meteorological Development Laboratory (MDL). Referred to as the "Tracking Meteogram", the tool aids NWS forecasters in assessing meteorological parameters associated with moving phenomena. The tool aids forecasters in severe weather situations by providing valuable satellite and radar derived trends such as cloud top cooling rates, radial velocity couplets, reflectivity, and information from ground-based lightning networks. The Tracking Meteogram tool also aids in synoptic and mesoscale analysis by tracking parameters such as the deepening of surface low pressure systems, changes in surface or upper air temperature, and other properties. The tool provides a valuable new functionality and demonstrates the flexibility and extensibility of the NWS AWIPS II architecture. In 2014, the operational impact of the tool was formally evaluated through participation in the NOAA/NWS Operations Proving Ground (OPG), a risk reduction activity to assess performance and operational impact of new forecasting concepts, tools, and applications. Performance of the Tracking Meteogram Tool during the OPG assessment confirmed that it will be a valuable asset to the operational forecasters. This presentation reviews development of the Tracking Meteogram tool, performance and feedback acquired during the OPG activity, and future goals for continued support and extension to other application areas.

  17. Vibrational spectra, normal coordinate analysis, and conformation of bis(ɑ-cyanoacetylacetonato)Cu(II)

    NASA Astrophysics Data System (ADS)

    Gandomi, Farzad; Vakili, Mohammad; Tayyari, Sayyed Faramarz

    2016-08-01

    Ab initio calculations, Natural Bond Orbital (NBO) and Atoms-in-Molecules (AIM) analyses, and Fourier transform Raman (3200-350 cm-1) and infrared (4000-200 cm-1) spectral measurements have been made for bis(α-cyanoacetylacetonato)Cu(II), Cu(CNacac)2. The molecular structure and vibrational spectra of Cu(CNacac)2 is compared with those of bis(acetylacetonato)Cu(II), Cu(acac)2. The molecular electronic energies and the equilibrium geometries for all theoretically possible conformations are calculated. A normal coordinate analysis of the vibrational modes has been computed for the most stable conformation of Cu(CNacac)2, D2h symmetry. A complete assignment of the observed band frequencies has been proposed. The metal-O bond strength was investigated by geometry calculations, NBO, AIM, and spectroscopic results to realize the effect of cyano substitution at α-position. All theoretical and vibrational spectroscopic studies confirm stronger metal-ligand bond in Cu(CNacac)2 than that in Cu(acac)2.

  18. Analysis of ice-binding sites in fish type II antifreeze protein by quantum mechanics.

    PubMed Central

    Cheng, Yuhua; Yang, Zuoyin; Tan, Hongwei; Liu, Ruozhuang; Chen, Guangju; Jia, Zongchao

    2002-01-01

    Many organisms living in cold environments can survive subzero temperatures by producing antifreeze proteins (AFPs) or antifreeze glycoproteins. In this paper we investigate the ice-binding surface of type II AFP by quantum mechanical methods, which, to the best of our knowledge, represents the first time that molecular orbital computational approaches have been applied to AFPs. Molecular mechanical approaches, including molecular docking, energy minimization, and molecular dynamics simulation, were used to obtain optimal systems for subsequent quantum mechanical analysis. We selected 17 surface patches covering the entire surface of the type II AFP and evaluated the interaction energy between each of these patches and two different ice planes using semi-empirical quantum mechanical methods. We have demonstrated the weak orbital overlay phenomenon and the change of bond orders in ice. These results consistently indicate that a surface patch containing 19 residues (K37, L38, Y20, E22, Y21, I19, L57, T56, F53, M127, T128, F129, R17, C7, N6, P5, G10, Q1, and W11) is the most favorable ice-binding site for both a regular ice plane and an ice plane where water O atoms are randomly positioned. Furthermore, for the first time the computation results provide new insights into the weakening of the ice lattice upon AFP binding, which may well be a primary factor leading to AFP-induced ice growth inhibition. PMID:12324437

  19. Analysis of the interaction of deuterium plasmas with tungsten in the Fuego-Nuevo II device

    NASA Astrophysics Data System (ADS)

    Ramos, Gonzalo; Castillo, Fermín; Nieto, Martín; Martínez, Marco; Rangel, José; Herrera-Velázquez, Julio

    2012-10-01

    Tungsten is one of the main candidate materials for plasma-facing components in future fusion power plants. The Fuego-Nuevo II, a plasma focus device, which can produce dense magnetized helium and deuterium plasmas, has been adapted to address plasma-facing materials questions. In this paper we present results of tungsten targets exposed to deuterium plasmas in the Fuego Nuevo II device, using different experimental conditions. The plasma generated and accelerated in the coaxial gun is expected to have, before the pinch, energies of the order of hundreds eV and velocities of the order of 40,000 m s-1. At the pinch, the ions are reported to have energies of the order of 1.5 keV at most. The samples, analysed with a scanning electron microscope (SEM) in cross section show a damage profile to depths of the order of 580 nm, which are larger than those expected for ions with 1.5 keV, and may be evidence of ion acceleration. An analysis with the SRIM (Stopping Range of Ions in Matter) package calculations is shown.

  20. Anion vacancies in II-VI chalcogenides: Review and critical analysis

    NASA Astrophysics Data System (ADS)

    Babentsov, V.; James, R. B.

    2013-09-01

    We performed critical analysis and comparison of all EPR, photo-EPR, photosensitive optical absorption, photoluminescence, and photoconductivity data taken on various Zn- and Cd-related II-VI chalcogenides compounds, such as ZnO, ZnS, ZnSe, and ZnTe, and CdS, CdSe, and CdTe. We developed a scheme for the electronic transitions and recombination associated with anion vacancies that is common for all these materials. This scheme explains all known facts obtained to date on quenching and excitation of the EPR signal, optical absorption, photoluminescence and photoconductivity. Based on these data we determined that the location of the energy level of the singly charged anion vacancy, VA+, is nearly equal for Zn-related II-VI materials (EC-1.0 eV) and EC+0.8 eV for Cd-related materials. For Cd-related chalcogenides most of the data were derived only from photoluminescence- and photoconductivity-spectra, so based on the available data, the position of the energy level of a singly charged anion vacancy in these materials was determined not so convincingly. Nonetheless, these materials have attracted much interest for decades because of their industrial applications as luminescent devices, laser filters and other optical elements, infrared, visible- and (X) γ-ray-detectors, solar cells, and the like.

  1. Analysis of the optical design of the NSLS-II coherent hard x-ray beamline

    NASA Astrophysics Data System (ADS)

    Fluerasu, Andrei; Chubar, Oleg; Kaznatcheev, Konstantine; Baltser, Jana; Wiegart, Lutz; Evans-Lutterodt, Kenneth; Carlucci-Dayton, Mary; Berman, Lonny

    2011-09-01

    microsecond time scales. In general, the 10-fold increase in brightness of the NSLS-II, compared to other sources, will allow for measurements of dynamics on time-scales that are two orders of magnitude faster than what is currently possible. We also conclude that the common approximations used in evaluating the transverse coherence length would not be sufficiently accurate for the calculation of the coherent properties of an undulator-based beamline, and a thorough beamline optimization at a low-emittance source such as the NSLS-II requires a realistic wave-front propagation analysis.

  2. Analysis of the optical design of the NSLS-II Coherent Hard X-ray beamline

    SciTech Connect

    Fluerasu A.; Chubar, O.; Kaznatcheev, K.; Baltser, J.; Wiegart, Lutz; Evans-Lutterodt, K.; Carlucci-Dayton, M.; Berman, L.

    2011-08-21

    microsecond time scales. In general, the 10-fold increase in brightness of the NSLS-II, compared to other sources, will allow for measurements of dynamics on time-scales that are two orders of magnitude faster than what is currently possible. We also conclude that the common approximations used in evaluating the transverse coherence length would not be sufficiently accurate for the calculation of the coherent properties of an undulator-based beamline, and a thorough beamline optimization at a low-emittance source such as the NSLS-II requires a realistic wave-front propagation analysis.

  3. Gravity Probe B data analysis: II. Science data and their handling prior to the final analysis

    NASA Astrophysics Data System (ADS)

    Silbergleit, A. S.; Conklin, J. W.; Heifetz, M. I.; Holmes, T.; Li, J.; Mandel, I.; Solomonik, V. G.; Stahl, K.; Worden, P. W., Jr.; Everitt, C. W. F.; Adams, M.; Berberian, J. E.; Bencze, W.; Clarke, B.; Al-Jadaan, A.; Keiser, G. M.; Kozaczuk, J. A.; Al-Meshari, M.; Muhlfelder, B.; Salomon, M.; Santiago, D. I.; Al-Suwaidan, B.; Turneaure, J. P.; Wade, J.

    2015-11-01

    The results of the Gravity Probe B relativity science mission published in Everitt et al (2011 Phys. Rev. Lett. 106 221101) required a rather sophisticated analysis of experimental data due to several unexpected complications discovered on-orbit. We give a detailed description of the Gravity Probe B data reduction. In the first paper (Silbergleit et al Class. Quantum Grav. 22 224018) we derived the measurement models, i.e., mathematical expressions for all the signals to analyze. In the third paper (Conklin et al Class. Quantum Grav. 22 224020) we explain the estimation algorithms and their program implementation, and discuss the experiment results obtained through data reduction. This paper deals with the science data preparation for the main analysis yielding the relativistic drift estimates.

  4. Studies in astronomical time series analysis. II - Statistical aspects of spectral analysis of unevenly spaced data

    NASA Technical Reports Server (NTRS)

    Scargle, J. D.

    1982-01-01

    Detection of a periodic signal hidden in noise is frequently a goal in astronomical data analysis. This paper does not introduce a new detection technique, but instead studies the reliability and efficiency of detection with the most commonly used technique, the periodogram, in the case where the observation times are unevenly spaced. This choice was made because, of the methods in current use, it appears to have the simplest statistical behavior. A modification of the classical definition of the periodogram is necessary in order to retain the simple statistical behavior of the evenly spaced case. With this modification, periodogram analysis and least-squares fitting of sine waves to the data are exactly equivalent. Certain difficulties with the use of the periodogram are less important than commonly believed in the case of detection of strictly periodic signals. In addition, the standard method for mitigating these difficulties (tapering) can be used just as well if the sampling is uneven. An analysis of the statistical significance of signal detections is presented, with examples

  5. The REFLEX II Galaxy Cluster sample: mock catalogues and clustering analysis

    NASA Astrophysics Data System (ADS)

    Balaguera-Antolinez, Andres; Sanchez, Ariel G.; Bohringer, Hans

    2012-09-01

    We present results of the analysis of abundance and clustering from the new ROSAT-ESO Flux-Limited X-Ray (REFLEX) II galaxy cluster catalogue. To model the covariance matrix of the different statistics, we have created a set of 100 mock galaxy cluster catalogues built from a suite large volume LambdaCDM N-Body simulations (L-BASICC and calibrated with the X-ray luminosity function. We discuss the calibration scheme and some implications regarding the cluster scaling relations, particularly, the link between mass and luminosity. Similarly we show the behavior of the clustering signal as a function of the X-ray luminosity and some cosmological implications.

  6. Comparative analysis of the cytotoxicity of substituted (phenylglyoxal bis(4-methyl-3-thiosemicarbazone)) copper (II) chelates.

    PubMed

    Coats, E A; Milstein, S R; Holbein, G; McDonald, J; Reed, R; Petering, H G

    1976-01-01

    Seven para-substituted [phenylglyoxal bis(4-methyl-3-thiosemicarbazone)]copper (II) chelates (12-18) have been designed, synthesized, and tested for their ability to inhibit the respiration of rat liver slices as a normal cell model and Ehrlich ascites cells as a tumor cell model. Relationships between chemical structure and respiratory inhibition are described on a quantitative basis using substituent contants (pi, Es, and sigmap) by computerized multiparameter regression analyses. The correlations indicate that changes in Es have the largest effect on liver slice toxicity of chelates while pi and sigmap account for most of the variation in toxicity to ascites cells. A comparative analysis strongly suggests that electron-donating substituents with greater water solubility should increase cytotoxicity to ascites cells at the expense of cytotoxicity to the rat liver cells. The predictions of the equations were checked by synthesizing and testing an additional derivative. The results strengthen the initial predictions. PMID:1246035

  7. Thermoplastic matrix composites - Finite-element analysis of mode I and mode II failure specimens

    NASA Technical Reports Server (NTRS)

    Bankert, Ray J.; Lambropoulos, Nicholas D.; Shephard, Mark S.; Sternstein, Sanford S.

    1989-01-01

    A finite-element analysis was conducted to evaluate the stress distributions within mode I and mode II failure specimens, assuming both isotropic and orthotropic elastic material properties. The effects of anisotropy on both the magnitude and the location of the highest stress concentration at the vicinity of the crack tip are significant. The results from modeling realistic blunt crack tip geometry and resin-rich zones imply that local variations in the microstructure strongly influence the stress state near the crack tip and therefore the measured fracture properties. In addition, the features of a viscoelastic model for thermoplastic matrices are described. This model will be used in future investigations of matrix-dominated failure phenomena.

  8. Analysis of molecular oxygen exit pathways in cyanobacterial photosystem II: Molecular dynamics studies

    NASA Astrophysics Data System (ADS)

    Gabdulkhakov, A. G.; Kljashtorny, V. G.; Dontsova, M. V.

    2015-11-01

    In thylakoids of cyanobacteria and other photosynthetic organisms, the light-induced production of molecular oxygen is catalyzed by the giant lipid-pigment-protein complex called photosystem II (PSII). The oxygen-evolving complex is buried deep in the lumenal part of PSII, and dioxygen molecules need to pass through the protein environment in order to leave the active site of the enzyme free. Previous studies aimed at finding oxygen channels in PSII were based on either an analysis of the cavities within is static structure or experiments on the insertion of noble gas molecules into PSII crystals under elevated pressure. In these studies, some possible exit pathways for the molecules were found and the static positions of molecular oxygen were determined. In the present work, the oxygen movement in the transport system of PSII is simulated by molecular dynamics.

  9. JUPITER-II Program: ANL analysis of ZPPR-13A and ZPPR-13B

    SciTech Connect

    Collins, P.J.; Brumbach, S.B.

    1984-08-09

    The ZPPR-13 experiments provide basic physics data for radial-heterogeneous LMFBR cores of approximately 700 MWe size. Assemblies ZPPR-13A, ZPPR-13B and ZPPR-13C comprised the JUPITER-II cooperative program between US-DOE and PNC of Japan. The measurements were made between August 1982 and April 1984. This report describes in detail the results of the ANL analyses of phases 13A and 13B/1 and includes preliminary results for the later assemblies of phase 13B. The data were compiled primarily for discussions at the Third Jupiter Analysis Meeting to be held at ANL-West between September 11th and 14th, 1984.

  10. Sensitivity Analysis of the DARHT-II 2.5MV/2kA Diode

    SciTech Connect

    Henestroza, Enrique

    2006-12-22

    This report summarizes the study of the tolerance limits on the assembly of the cathode and the Pierce electrode for the DARHT-II diode (2.5 MV, 2 kA case), performed through a series of computer simulations using the PIC code WARP [1]. We have considered sources of beam quality degradation like the errors in axial and transverse positioning, and the size of the radial gap between the cathode and the Pierce electrode (shroud). The figure of merit was chosen to be the RMS beam (edge) emittance at a distance of 1 meter from the cathode, as defined by {var_epsilon}{sub x} = 4 {beta}{gamma} {radical}(-{sup 2}) {center_dot}. The analysis shows that to position the cathode at the correct axial and transverse location is more important than the size of the radial gap.

  11. The acoustic simulation and analysis of complicated reciprocating compressor piping systems, II: Program structure and applications

    NASA Astrophysics Data System (ADS)

    To, C. W. S.

    1984-09-01

    The main objectives of the investigation reported in this paper, Part II, and its companion paper, Part I, are (a) to provide a formulation, including the mean flow effects and suitable for digital computer automation, of the acoustics of complicated piping systems, and (b) to develop a comprehensive digital computer program for the simulation and analysis of complicated reciprocating compressor piping systems. In this paper, the digital computer program structure and applications of the program developed, written in Fortran IV, are described. It is concluded that the computer program is versatile and user-friendly. It is capable of providing a great deal of information from one set of input data, and is open-ended and modular for updating.

  12. Synthesis and spectroscopic characterization of copper(II) tetraazaiminooxime macrocyclic complexes--a tetragonal distortion analysis.

    PubMed

    Protasiewyck, Gisele Marina; Nunes, Fábio Souza

    2006-11-01

    Herein we describe the synthesis and spectroscopic (infrared and UV-vis) analysis of [Cu(II)(dohpn)(L)](n+) (dohpn=imineoximic tetraazamacrocyclic ligand 2,3,9,10-tetramethyl-1,4,8,11-tetraazaundecane-1,3,8,10-tetraen-11-ol-1-olate) and L=SCN(-), I(-), Cl(-) (n=0) and 4-aminopyridine (ampy), 4,4'-bipyridine (bipy), imidazole (im), 2-aminopyrazine (ampz) and water (n=1+). The following order of the Jahn-Teller stabilization energy (cm(-1)) was observed: I(-)(6452)

  13. Compatibility of motion facilitates visuomotor synchronization.

    PubMed

    Hove, Michael J; Spivey, Michael J; Krumhansl, Carol L

    2010-12-01

    Prior research indicates that synchronized tapping performance is very poor with flashing visual stimuli compared with auditory stimuli. Three finger-tapping experiments compared flashing visual metronomes with visual metronomes containing a spatial component, either compatible, incompatible, or orthogonal to the tapping action. In Experiment 1, synchronization success rates increased dramatically for spatiotemporal sequences of both geometric and biological forms over flashing sequences. In Experiment 2, synchronization performance was best when target sequences and movements were directionally compatible (i.e., simultaneously down), followed by orthogonal stimuli, and was poorest for incompatible moving stimuli and flashing stimuli. In Experiment 3, synchronization performance was best with auditory sequences, followed by compatible moving stimuli, and was worst for flashing and fading stimuli. Results indicate that visuomotor synchronization improves dramatically with compatible spatial information. However, an auditory advantage in sensorimotor synchronization persists. PMID:20695698

  14. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  15. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  16. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... a connector by the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry...) TTY signal compatibility. Products, including those providing voice communication functionality,...

  17. 36 CFR 1193.51 - Compatibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... the user. (b) Connection point for external audio processing devices. Products providing auditory output shall provide the auditory signal at a standard signal level through an industry standard... signal compatibility. Products, including those providing voice communication functionality,...

  18. The Mars Environmental Compatibility Assessment (MECA)

    NASA Technical Reports Server (NTRS)

    Hecht, M. H.; Meloy, T. P.; Marshall, J. R.

    2000-01-01

    Originally selected for the HEDS dust & soil payload for the 2001 Mars Surveyor Lander, The Mars Environmental Compatibility Assessment (MECA) has now been completed, tested, and is ready for flight. This paper will review the four MECA instruments.

  19. Integrated Data Collection Analysis (IDCA) Program - RDX Type II Class 5 Standard, Data Set 1

    SciTech Connect

    Sandstrom, Mary M.; Brown, Geoffrey W.; Preston, Daniel N.; Pollard, Colin J.; Warner, Kirstin F.; Sorenson, Daniel N.; Remmers, Daniel L.; Moran, Jesse S.; Shelley, Timothy J.; Reyes, Jose A.; Hsu, Peter C.; Whipple, Richard E.; Reynolds, John G.

    2011-04-11

    This document describes the results of the first reference sample material—RDX Type II Class 5—examined in the proficiency study for small-scale safety and thermal (SSST) testing of explosive materials for the Integrated Data Collection Analysis (IDCA) Program. The IDCA program is conducting proficiency testing on homemade explosives (HMEs). The reference sample materials are being studied to establish the accuracy of traditional explosives safety testing for each performing laboratory. These results will be used for comparison to results from testing HMEs. This effort, funded by the Department of Homeland Security (DHS), ultimately will put the issues of safe handling of these materials in perspective with standard military explosives. The results of the study will add SSST testing results for a broad suite of different HMEs to the literature, potentially suggest new guidelines and methods for HME testing, and possibly establish what are the needed accuracies in SSST testing to develop safe handling practices. Described here are the results for impact, friction, electrostatic discharge, and scanning calorimetry analysis of a reference sample of RDX Type II Class 5. The results from each participating testing laboratory are compared using identical test material and preparation methods wherever possible. Note, however, the test procedures differ among the laboratories. These results are then compared to historical data from various sources. The performers involved are Lawrence Livermore National Laboratory (LLNL), Los Alamos National Laboratory (LANL), Air Force Research Laboratory/ RXQL (AFRL), Indian Head Division, Naval Surface Warfare Center, (IHD-NSWC), and Sandia National Laboratories (SNL). These tests are conducted as a proficiency study in order to establish some consistency in test protocols, procedures, and experiments and to understand how to compare results when test protocols are not identical.

  20. EVA-Compatible Microbial Swab Tool

    NASA Technical Reports Server (NTRS)

    Rucker, Michelle A.

    2016-01-01

    When we send humans to search for life on Mars, we'll need to know what we brought with us versus what may already be there. To ensure our crewed spacecraft meet planetary protection requirements—and to protect our science from human contamination—we'll need to know whether micro-organisms are leaking/venting from our ships and spacesuits. This is easily done by swabbing external vents and suit surfaces for analysis, but requires a specialized tool for the job. Engineers at the National Aeronautics and Space Administration (NASA) recently developed an Extravehicular Activity (EVA)-compatible swab tool that can be used to sample current space suits and life support systems. Data collected now will influence Mars life support and EVA hardware early in the planning process, before design changes become difficult and expensive.NASA’s EVA swab tool pairs a Space Shuttle-era tool handle with a commercially available swab tip mounted into a custom-designed end effector. A glove-compatible release mechanism allows the handle to quickly switch between swab tips, much like a shaving razor handle can snap onto a disposable blade cartridge. Swab tips are stowed inside individual sterile containers, each fitted with a microbial filter that allows the container to equalize atmospheric pressure, but prevents cabin contaminants from rushing into the container when passing from the EVA environment into a pressurized cabin. A bank of containers arrayed inside a tool caddy allows up to six individual samples to be collected during a given spacewalk.NASA plans to use the tool in 2016 to collect samples from various spacesuits during ground testing to determine what (if any) human-borne microbial contamination leaks from the suit under simulated thermal vacuum conditions. Next, the tool will be used on board the International Space Station to assess the types of microbial contaminants found on external environmental control and life support system vents. Data will support

  1. Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples.

    PubMed Central

    Peto, R.; Pike, M. C.; Armitage, P.; Breslow, N. E.; Cox, D. R.; Howard, S. V.; Mantel, N.; McPherson, K.; Peto, J.; Smith, P. G.

    1977-01-01

    Part I of this report appeared in the previous issue (Br. J. Cancer (1976) 34,585), and discussed the design of randomized clinical trials. Part II now describes efficient methods of analysis of randomized clinical trials in which we wish to compare the duration of survival (or the time until some other untoward event first occurs) among different groups of patients. It is intended to enable physicians without statistical training either to analyse such data themselves using life tables, the logrank test and retrospective stratification, or, when such analyses are presented, to appreciate them more critically, but the discussion may also be of interest to statisticians who have not yet specialized in clinical trial analyses. PMID:831755

  2. p-exponent and p-leaders, Part II: Multifractal analysis. Relations to detrended fluctuation analysis

    NASA Astrophysics Data System (ADS)

    Leonarduzzi, R.; Wendt, H.; Abry, P.; Jaffard, S.; Melot, C.; Roux, S. G.; Torres, M. E.

    2016-04-01

    Multifractal analysis studies signals, functions, images or fields via the fluctuations of their local regularity along time or space, which capture crucial features of their temporal/spatial dynamics. It has become a standard signal and image processing tool and is commonly used in numerous applications of different natures. In its common formulation, it relies on the Hölder exponent as a measure of local regularity, which is by nature restricted to positive values and can hence be used for locally bounded functions only. In this contribution, it is proposed to replace the Hölder exponent with a collection of novel exponents for measuring local regularity, the p-exponents. One of the major virtues of p-exponents is that they can potentially take negative values. The corresponding wavelet-based multiscale quantities, the p-leaders, are constructed and shown to permit the definition of a new multifractal formalism, yielding an accurate practical estimation of the multifractal properties of real-world data. Moreover, theoretical and practical connections to and comparisons against another multifractal formalism, referred to as multifractal detrended fluctuation analysis, are achieved. The performance of the proposed p-leader multifractal formalism is studied and compared to previous formalisms using synthetic multifractal signals and images, illustrating its theoretical and practical benefits. The present contribution is complemented by a companion article studying in depth the theoretical properties of p-exponents and the rich classification of local singularities it permits.

  3. Multicomponent Analysis of Junctional Movements Regulated by Myosin II Isoforms at the Epithelial Zonula Adherens

    PubMed Central

    Smutny, Michael; Wu, Selwin K.; Gomez, Guillermo A.; Mangold, Sabine; Yap, Alpha S.; Hamilton, Nicholas A.

    2011-01-01

    The zonula adherens (ZA) of epithelial cells is a site of cell-cell adhesion where cellular forces are exerted and resisted. Increasing evidence indicates that E-cadherin adhesion molecules at the ZA serve to sense force applied on the junctions and coordinate cytoskeletal responses to those forces. Efforts to understand the role that cadherins play in mechanotransduction have been limited by the lack of assays to measure the impact of forces on the ZA. In this study we used 4D imaging of GFP-tagged E-cadherin to analyse the movement of the ZA. Junctions in confluent epithelial monolayers displayed prominent movements oriented orthogonal (perpendicular) to the ZA itself. Two components were identified in these movements: a relatively slow unidirectional (translational) component that could be readily fitted by least-squares regression analysis, upon which were superimposed more rapid oscillatory movements. Myosin IIB was a dominant factor responsible for driving the unilateral translational movements. In contrast, frequency spectrum analysis revealed that depletion of Myosin IIA increased the power of the oscillatory movements. This implies that Myosin IIA may serve to dampen oscillatory movements of the ZA. This extends our recent analysis of Myosin II at the ZA to demonstrate that Myosin IIA and Myosin IIB make distinct contributions to junctional movement at the ZA. PMID:21799860

  4. New tools for the systematic analysis and visualization of electronic excitations. II. Applications.

    PubMed

    Plasser, Felix; Bäppler, Stefanie A; Wormit, Michael; Dreuw, Andreas

    2014-07-14

    The excited states of a diverse set of molecules are examined using a collection of newly implemented analysis methods. These examples expose the particular power of three of these tools: (i) natural difference orbitals (the eigenvectors of the difference density matrix) for the description of orbital relaxation effects, (ii) analysis of the one-electron transition density matrix in terms of an electron-hole picture to identify charge resonance and excitonic correlation effects, and (iii) state-averaged natural transition orbitals for a compact simultaneous representation of several states. Furthermore, the utility of a wide array of additional analysis methods is highlighted. Five molecules with diverse excited state characteristics are chosen for these tasks: pyridine as a prototypical small heteroaromatic molecule, a model system of six neon atoms to study charge resonance effects, hexatriene in its neutral and radical cation forms to exemplify the cases of double excitations and spin-polarization, respectively, and a model iridium complex as a representative metal organic compound. Using these examples a number of phenomena, which are at first sight unexpected, are highlighted and their physical significance is discussed. Moreover, the generality of the conclusions of this paper is verified by a comparison of single- and multireference ab initio methods. PMID:25027999

  5. New tools for the systematic analysis and visualization of electronic excitations. II. Applications

    SciTech Connect

    Plasser, Felix Bäppler, Stefanie A.; Wormit, Michael; Dreuw, Andreas

    2014-07-14

    The excited states of a diverse set of molecules are examined using a collection of newly implemented analysis methods. These examples expose the particular power of three of these tools: (i) natural difference orbitals (the eigenvectors of the difference density matrix) for the description of orbital relaxation effects, (ii) analysis of the one-electron transition density matrix in terms of an electron-hole picture to identify charge resonance and excitonic correlation effects, and (iii) state-averaged natural transition orbitals for a compact simultaneous representation of several states. Furthermore, the utility of a wide array of additional analysis methods is highlighted. Five molecules with diverse excited state characteristics are chosen for these tasks: pyridine as a prototypical small heteroaromatic molecule, a model system of six neon atoms to study charge resonance effects, hexatriene in its neutral and radical cation forms to exemplify the cases of double excitations and spin-polarization, respectively, and a model iridium complex as a representative metal organic compound. Using these examples a number of phenomena, which are at first sight unexpected, are highlighted and their physical significance is discussed. Moreover, the generality of the conclusions of this paper is verified by a comparison of single- and multireference ab initio methods.

  6. Preliminary design analysis of the ALT-II limiter for TEXTOR

    SciTech Connect

    Koski, J.A.; Boyd, R.D.; Kempka, S.M.; Romig, A.D. Jr.; Smith, M.F.; Watson, R.D.; Whitley, J.B.; Conn, R.W.; Grotz, S.P.

    1983-01-01

    Installation of a large toroidal belt pump limiter, Advanced Limiter Test II (ALT-II), on the TEXTOR tokamak at Juelich, FRG is anticipated for early 1986. This paper discusses the preliminary mechanical design and materials considerations undertaken as part of the feasibility study phase for ALT-II.

  7. Confirmatory Factor Analysis of the Beck Depression Inventory-II in Bariatric Surgery Candidates

    ERIC Educational Resources Information Center

    Hall, Brian J.; Hood, Megan M.; Nackers, Lisa M.; Azarbad, Leila; Ivan, Iulia; Corsica, Joyce

    2013-01-01

    Screening for depression is an integral part of psychological evaluations conducted prior to bariatric surgery. The Beck Depression Inventory-II (BDI-II) is the most commonly used measure of depression in these treatment evaluations. The reliability and validity of the BDI-II has not yet been evaluated within bariatric surgery-seeking samples,…

  8. Launch Vehicle Fire Accident Preliminary Analysis of a Liquid-Metal Cooled Thermionic Nuclear Reactor: TOPAZ-II

    NASA Astrophysics Data System (ADS)

    Hu, G.; Zhao, S.; Ruan, K.

    2012-01-01

    In this paper, launch vehicle propellant fire accident analysis of TOPAZ-II reactor has been done by a thermionic reactor core analytic code-TATRHG(A) developed by author. When a rocket explodes on a launch pad, its payload-TOPAZ-II can be subjected to a severe thermal environment from the resulting fireball. The extreme temperatures associated with propellant fires can create a destructive environment in or near the fireball. Different kind of propellants - liquid propellant and solid propellant which will lead to different fire temperature are considered. Preliminary analysis shows that the solid propellant fires can melt the whole toxic beryllium radial reflector.

  9. Mate choice for genetic compatibility in the house mouse

    PubMed Central

    Lindholm, Anna K; Musolf, Kerstin; Weidt, Andrea; König, Barbara

    2013-01-01

    In house mice, genetic compatibility is influenced by the t haplotype, a driving selfish genetic element with a recessive lethal allele, imposing fundamental costs on mate choice decisions. Here, we evaluate the cost of genetic incompatibility and its implication for mate choice in a wild house mice population. In laboratory reared mice, we detected no fertility (number of embryos) or fecundity (ability to conceive) costs of the t, and yet we found a high cost of genetic incompatibility: heterozygote crosses produced 40% smaller birth litter sizes because of prenatal mortality. Surprisingly, transmission of t in crosses using +/t males was influenced by female genotype, consistent with postcopulatory female choice for + sperm in +/t females. Analysis of paternity patterns in a wild population of house mice showed that +/t females were more likely than +/+ females to have offspring sired by +/+ males, and unlike +/+ females, paternity of their offspring was not influenced by +/t male frequency, further supporting mate choice for genetic compatibility. As the major histocompatibility complex (MHC) is physically linked to the t, we investigated whether females could potentially use variation at the MHC to identify male genotype at the sperm or individual level. A unique MHC haplotype is linked to the t haplotype. This MHC haplotype could allow the recognition of t and enable pre- and postcopulatory mate choice for genetic compatibility. Alternatively, the MHC itself could be the target of mate choice for genetic compatibility. We predict that mate choice for genetic compatibility will be difficult to find in many systems, as only weak fertilization biases were found despite an exceptionally high cost of genetic incompatibility. PMID:23762510

  10. Surface complexation and precipitate geometry for aqueous Zn(II) sorption on ferrihydrite: II. XANES analysis and simulation

    USGS Publications Warehouse

    Waychunas, G.A.; Fuller, C.C.; Davis, J.A.; Rehr, J.J.

    2003-01-01

    X-ray absorption near-edge spectroscopy (XANES) analysis of sorption complexes has the advantages of high sensitivity (10- to 20-fold greater than extended X-ray absorption fine structure [EXAFS] analysis) and relative ease and speed of data collection (because of the short k-space range). It is thus a potentially powerful tool for characterization of environmentally significant surface complexes and precipitates at very low surface coverages. However, quantitative analysis has been limited largely to "fingerprint" comparison with model spectra because of the difficulty of obtaining accurate multiple-scattering amplitudes for small clusters with high confidence. In the present work, calculations of the XANES for 50- to 200-atom clusters of structure from Zn model compounds using the full multiple-scattering code Feff 8.0 accurately replicate experimental spectra and display features characteristic of specific first-neighbor anion coordination geometry and second-neighbor cation geometry and number. Analogous calculations of the XANES for small molecular clusters indicative of precipitation and sorption geometries for aqueous Zn on ferrihydrite, and suggested by EXAFS analysis, are in good agreement with observed spectral trends with sample composition, with Zn-oxygen coordination and with changes in second-neighbor cation coordination as a function of sorption coverage. Empirical analysis of experimental XANES features further verifies the validity of the calculations. The findings agree well with a complete EXAFS analysis previously reported for the same sample set, namely, that octahedrally coordinated aqueous Zn2+ species sorb as a tetrahedral complex on ferrihydrite with varying local geometry depending on sorption density. At significantly higher densities but below those at which Zn hydroxide is expected to precipitate, a mainly octahedral coordinated Zn2+ precipitate is observed. An analysis of the multiple scattering paths contributing to the XANES

  11. Synthesis of artificial spectrum-compatible seismic accelerograms

    NASA Astrophysics Data System (ADS)

    Vrochidou, E.; Alvanitopoulos, P. F.; Andreadis, I.; Elenas, A.; Mallousi, K.

    2014-08-01

    The Hilbert-Huang transform is used to generate artificial seismic signals compatible with the acceleration spectra of natural seismic records. Artificial spectrum-compatible accelerograms are utilized instead of natural earthquake records for the dynamic response analysis of many critical structures such as hospitals, bridges, and power plants. The realistic estimation of the seismic response of structures involves nonlinear dynamic analysis. Moreover, it requires seismic accelerograms representative of the actual ground acceleration time histories expected at the site of interest. Unfortunately, not many actual records of different seismic intensities are available for many regions. In addition, a large number of seismic accelerograms are required to perform a series of nonlinear dynamic analyses for a reliable statistical investigation of the structural behavior under earthquake excitation. These are the main motivations for generating artificial spectrum-compatible seismic accelerograms and could be useful in earthquake engineering for dynamic analysis and design of buildings. According to the proposed method, a single natural earthquake record is deconstructed into amplitude and frequency components using the Hilbert-Huang transform. The proposed method is illustrated by studying 20 natural seismic records with different characteristics such as different frequency content, amplitude, and duration. Experimental results reveal the efficiency of the proposed method in comparison with well-established and industrial methods in the literature.

  12. A Comparative Review of Sensitivity and Uncertainty Analysis of Large-Scale Systems - II: Statistical Methods

    SciTech Connect

    Cacuci, Dan G.; Ionescu-Bujor, Mihaela

    2004-07-15

    Part II of this review paper highlights the salient features of the most popular statistical methods currently used for local and global sensitivity and uncertainty analysis of both large-scale computational models and indirect experimental measurements. These statistical procedures represent sampling-based methods (random sampling, stratified importance sampling, and Latin Hypercube sampling), first- and second-order reliability algorithms (FORM and SORM, respectively), variance-based methods (correlation ratio-based methods, the Fourier Amplitude Sensitivity Test, and the Sobol Method), and screening design methods (classical one-at-a-time experiments, global one-at-a-time design methods, systematic fractional replicate designs, and sequential bifurcation designs). It is emphasized that all statistical uncertainty and sensitivity analysis procedures first commence with the 'uncertainty analysis' stage and only subsequently proceed to the 'sensitivity analysis' stage; this path is the exact reverse of the conceptual path underlying the methods of deterministic sensitivity and uncertainty analysis where the sensitivities are determined prior to using them for uncertainty analysis. By comparison to deterministic methods, statistical methods for uncertainty and sensitivity analysis are relatively easier to develop and use but cannot yield exact values of the local sensitivities. Furthermore, current statistical methods have two major inherent drawbacks as follows: 1. Since many thousands of simulations are needed to obtain reliable results, statistical methods are at best expensive (for small systems) or, at worst, impracticable (e.g., for large time-dependent systems).2. Since the response sensitivities and parameter uncertainties are inherently and inseparably amalgamated in the results produced by these methods, improvements in parameter uncertainties cannot be directly propagated to improve response uncertainties; rather, the entire set of simulations and

  13. X-ray photoelectron spectroscopic and Raman analysis of silk fibroin-Cu(II) films.

    PubMed

    Zhou, Li; Chen, Xin; Dai, Weilin; Shao, Zhengzhong

    2006-06-01

    There is evidence to suggest that Cu(II) is involved in the natural spinning process of a silkworm helping to convert the concentrated silk fibroin (SF) solution (or dope) into tough insoluble threads. To investigate the interaction between SF and Cu(II), a series of regenerated SF (RSF) films with different mass ratios of Cu(II) to SF were prepared. X-ray photoelectron spectroscopy (XPS) was employed to study the chemical interaction between Cu(II) and SF in these Cu(II)-RSF films. A significant change in the binding energy of Cu 2p(3/2) demonstrated that the chemical state of Cu(II) in the Cu(II)-RSF films was affected by the interaction between Cu(II) and SF. Moreover, chemical shifts of N 1s and O 1s of SF were also detected, implying that Cu(II) may coordinate with both N and O atoms in the SF. In addition, Raman spectra of the same series of Cu(II)-RSF films recorded the conformation transition of SF that may occur by the coordination of Cu(II) and SF macromolecular chains. PMID:16463361

  14. Microscale Synthesis and (super 1)H NMR Analysis of Zn(super II) and Ni(super II) Tetraphenylporphyrins

    ERIC Educational Resources Information Center

    Saucedo, Laura; Mink, Larry M.

    2005-01-01

    A multisection undergraduate laboratory involving the microscale synthesis and spectroscopic analysis of unmetalled porphyrins and their corresponding metalloporphyins is described. The microscale synthesis involving the isolation of the metalloporphyrins as solids and their corresponding (super 1)H NMR spectra are presented.

  15. Evaluating the compatibility of multi-functional and intensive urban land uses

    NASA Astrophysics Data System (ADS)

    Taleai, M.; Sharifi, A.; Sliuzas, R.; Mesgari, M.

    2007-12-01

    This research is aimed at developing a model for assessing land use compatibility in densely built-up urban areas. In this process, a new model was developed through the combination of a suite of existing methods and tools: geographical information system, Delphi methods and spatial decision support tools: namely multi-criteria evaluation analysis, analytical hierarchy process and ordered weighted average method. The developed model has the potential to calculate land use compatibility in both horizontal and vertical directions. Furthermore, the compatibility between the use of each floor in a building and its neighboring land uses can be evaluated. The method was tested in a built-up urban area located in Tehran, the capital city of Iran. The results show that the model is robust in clarifying different levels of physical compatibility between neighboring land uses. This paper describes the various steps and processes of developing the proposed land use compatibility evaluation model (CEM).

  16. Composite laminate free-edge reinforcement with U-shaped caps. I - Stress analysis. II - Theoretical-experimental correlation

    NASA Technical Reports Server (NTRS)

    Howard, W. E.; Gossard, Terry, Jr.; Jones, Robert M.

    1989-01-01

    The present generalized plane-strain FEM analysis for the prediction of interlaminar normal stress reduction when a U-shaped cap is bonded to the edge of a composite laminate gives attention to the highly variable transverse stresses near the free edge, cap length and thickness, and a gap under the cap due to the manufacturing process. The load-transfer mechanism between cap and laminate is found to be strain-compatibility, rather than shear lag. In the second part of this work, the three-dimensional composite material failure criteria are used in a progressive laminate failure analysis to predict failure loads of laminates with different edge-cap designs; symmetric 11-layer graphite-epoxy laminates with a one-layer cap of kevlar-epoxy are shown to carry 130-140 percent greater loading than uncapped laminates, under static tensile and tension-tension fatigue loading.

  17. Accident consequences analysis of the HYLIFE-II inertial fusion energy power plant design

    NASA Astrophysics Data System (ADS)

    Reyes, S.; Latkowski, J. F.; Gomez del Rio, J.; Sanz, J.

    2001-05-01

    Previous studies of the safety and environmental aspects of the HYLIFE-II inertial fusion energy power plant design have used simplistic assumptions in order to estimate radioactivity releases under accident conditions. Conservatisms associated with these traditional analyses can mask the actual behavior of the plant and have revealed the need for more accurate modeling and analysis of accident conditions and radioactivity mobilization mechanisms. In the present work, computer codes traditionally used for magnetic fusion safety analyses (CHEMCON, MELCOR) have been applied for simulating accident conditions in a simple model of the HYLIFE-II IFE design. Here we consider a severe loss of coolant accident (LOCA) in conjunction with simultaneous failures of the beam tubes (providing a pathway for radioactivity release from the vacuum vessel towards the confinement) and of the two barriers surrounding the chamber (inner shielding and confinement building itself). Even though confinement failure would be a very unlikely event it would be needed in order to produce significant off-site doses. CHEMCON code allows calculation of long-term temperature transients in fusion reactor first wall, blanket, and shield structures resulting from decay heating. MELCOR is used to simulate a wide range of physical phenomena including thermal-hydraulics, heat transfer, aerosol physics and fusion product transport and release. The results of these calculations show that the estimated off-site dose is less than 5 mSv (0.5 rem), which is well below the value of 10 mSv (1 rem) given by the DOE Fusion Safety Standards for protection of the public from exposure to radiation during off-normal conditions.

  18. Analysis of SBIR phase I and phase II review results at the National Institutes of Health.

    PubMed

    Vener, K J; Calkins, B M

    1991-09-01

    A cohort of phase I and phase II summary statements for the SBIR grant applications was evaluated to determine the strengths and weaknesses in approved and disapproved applications. An analysis of outcome variables (disapproval or unfunded status) was examined with respect to exposure variables (strengths or shortcomings). Logistic regression models were developed for comparisons to measure the predictive value of shortcomings and strengths to the outcomes. Disapproved phase I results were compared with an earlier 1985 study. Although the magnitude of the frequencies of shortcomings was greater in the present study, the relative rankings within shortcoming class were more alike than different. Also, the frequencies of shortcomings were, with one exception, not significantly different in the two studies. Differences in the summary statement review may have accounted for some differences observed between the 1985 data and results of the present study. Comparisons of Approved/Disapproved and Approved-Unfunded/Funded yielded the following observations. For phase I applicants, a lack of a clearly stated, testable hypothesis, a poorly qualified or described investigative team, and inadequate methodological approaches contributed significantly (in that order) to a rating of disapproval. A critical flaw for phase II proposals was failure to accomplish objectives of the phase I study. Methodological issues also dominate the distinctions in both comparison groups. A clear result of the data presented here and that published previously is that SBIR applicants need continuing assistance to improve the chances of their success. These results should serve as a guide to assist NIH staff as they provide information to prospective applicants focusing on key elements of the application. A continuing review of the SBIR program would be helpful to evaluate the quality of the submitted science. PMID:1916087

  19. Accident consequences analysis of the HYLIFE-II inertial fusion energy power plant design

    SciTech Connect

    Reyes, S; Gomez del Rio, J; Sanz, J

    2000-02-23

    Previous studies of the safety and environmental (S and E) aspects of the HYLIFE-II inertial fusion energy (IFE) power plant design have used simplistic assumptions in order to estimate radioactivity releases under accident conditions. Conservatisms associated with these traditional analyses can mask the actual behavior of the plant and have revealed the need for more accurate modeling and analysis of accident conditions and radioactivity mobilization mechanisms. In the present work a set of computer codes traditionally used for magnetic fusion safety analyses (CHEMCON, MELCOR) has been applied for simulating accident conditions in a simple model of the HYLIFE-II IFE design. Here the authors consider a severe lost of coolant accident (LOCA) producing simultaneous failures of the beam tubes (providing a pathway for radioactivity release from the vacuum vessel towards the containment) and of the two barriers surrounding the chamber (inner shielding and containment building it self). Even though containment failure would be a very unlikely event it would be needed in order to produce significant off-site doses. CHEMCON code allows calculation of long-term temperature transients in fusion reactor first wall, blanket, and shield structures resulting from decay heating. MELCOR is used to simulate a wide range of physical phenomena including thermal-hydraulics, heat transfer, aerosol physics and fusion product release and transport. The results of these calculations show that the estimated off-site dose is less than 6 mSv (0.6 rem), which is well below the value of 10 mSv (1 rem) given by the DOE Fusion Safety Standards for protection of the public from exposure to radiation during off-normal conditions.

  20. Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1

    PubMed Central

    Schwer, Beate; Ghosh, Agnidipta; Sanchez, Ana M.; Lima, Christopher D.; Shuman, Stewart

    2015-01-01

    Protein phosphatases regulate mRNA synthesis and processing by remodeling the carboxy-terminal domain (CTD) of RNA polymerase II (Pol2) to dynamically inscribe a Pol2 CTD code. Fission yeast Fcp1 (SpFcp1) is an essential 723-amino acid CTD phosphatase that preferentially hydrolyzes Ser2-PO4 of the YS2PTSPS repeat. The SpFcp1 catalytic domain (aa 140–580) is composed of a DxDxT acyl-phosphatase module (FCPH) and a BRCT module. Here we conducted a genetic analysis of SpFcp1, which shows that (i) phosphatase catalytic activity is required for vegetative growth of fission yeast; (ii) the flanking amino-terminal domain (aa 1–139) and its putative metal-binding motif C99H101Cys109C112 are essential; (iii) the carboxy-terminal domain (aa 581–723) is dispensable; (iv) a structurally disordered internal segment of the FCPH domain (aa 330–393) is dispensable; (v) lethal SpFcp1 mutations R271A and R299A are rescued by shortening the Pol2 CTD repeat array; and (vi) CTD Ser2-PO4 is not the only essential target of SpFcp1 in vivo. Recent studies highlight a second CTD code involving threonine phosphorylation of a repeat motif in transcription elongation factor Spt5. We find that Fcp1 can dephosphorylate Thr1-PO4 of the fission yeast Spt5 CTD nonamer repeat T1PAWNSGSK. We identify Arg271 as a governor of Pol2 versus Spt5 CTD substrate preference. Our findings implicate Fcp1 as a versatile sculptor of both the Pol2 and Spt5 CTD codes. Finally, we report a new 1.45 Å crystal structure of SpFcp1 with Mg2+ and AlF3 that mimics an associative phosphorane transition state of the enzyme-aspartyl-phosphate hydrolysis reaction. PMID:25883047

  1. Cloning, characterization and expression analysis of coagulation factor II gene in grass carp (Ctenopharyngodon idella).

    PubMed

    Xu, B H; Chen, K J; Yao, Y B; Liu, Q L; Xiao, T Y; Su, J M; Peng, H Z

    2015-01-01

    Here, we characterized the structure and function of the coagulation factor II (FII) gene in grass carp and determined its role in coagulation mechanisms. The FII gene EST was obtained using a constructed splenic transcriptome database; the full-length FII gene sequence was obtained by 3' and 5' RACE. The open reading frame (ORF) of FII was cloned and the full-length gene was found to be 1718 bp, with an ORF of 1572 bp; the gene contained a 25 bp 5'-untranslated region (UTR) and 108 bp 3'-UTR. The ORF encoded 524 amino acids, including 74 alkaline amino acids (arginine and lysine) and 69 acidic amino acids (aspartic acid and glutamic acid). The theoretical pI was 6.22. The calculated instability index (II) was 39.81, indicating that FII was a stable protein; the half-life period was predicted to be approximately 30 h. Amino acid sequence comparisons indicated that grass carp FII showed most similarity (71%) to FII of Takifugu rubripes, followed by Oplegnathus fasciatus (48% similarity) and Larimichthys crocea (47% similarity). A real-time reverse transcription PCR analysis showed that under normal circumstances, FII was most highly expressed in the liver, followed by the gill, spleen, thymus, and head-kidney (P < 0.001). After injection of the grass carp reovirus 873 (GCRV873), the pattern of FII expression was significantly altered (P < 0.001); gene expression was high after injection, suggesting a response involving the initiation of the coagulation system and defense of the body in combination with the platelet and complement system. PMID:26535692

  2. Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1.

    PubMed

    Schwer, Beate; Ghosh, Agnidipta; Sanchez, Ana M; Lima, Christopher D; Shuman, Stewart

    2015-06-01

    Protein phosphatases regulate mRNA synthesis and processing by remodeling the carboxy-terminal domain (CTD) of RNA polymerase II (Pol2) to dynamically inscribe a Pol2 CTD code. Fission yeast Fcp1 (SpFcp1) is an essential 723-amino acid CTD phosphatase that preferentially hydrolyzes Ser2-PO4 of the YS(2)PTSPS repeat. The SpFcp1 catalytic domain (aa 140-580) is composed of a DxDxT acyl-phosphatase module (FCPH) and a BRCT module. Here we conducted a genetic analysis of SpFcp1, which shows that (i) phosphatase catalytic activity is required for vegetative growth of fission yeast; (ii) the flanking amino-terminal domain (aa 1-139) and its putative metal-binding motif C(99)H(101)Cys(109)C(112) are essential; (iii) the carboxy-terminal domain (aa 581-723) is dispensable; (iv) a structurally disordered internal segment of the FCPH domain (aa 330-393) is dispensable; (v) lethal SpFcp1 mutations R271A and R299A are rescued by shortening the Pol2 CTD repeat array; and (vi) CTD Ser2-PO4 is not the only essential target of SpFcp1 in vivo. Recent studies highlight a second CTD code involving threonine phosphorylation of a repeat motif in transcription elongation factor Spt5. We find that Fcp1 can dephosphorylate Thr1-PO4 of the fission yeast Spt5 CTD nonamer repeat T(1)PAWNSGSK. We identify Arg271 as a governor of Pol2 versus Spt5 CTD substrate preference. Our findings implicate Fcp1 as a versatile sculptor of both the Pol2 and Spt5 CTD codes. Finally, we report a new 1.45 Å crystal structure of SpFcp1 with Mg(2+) and AlF3 that mimics an associative phosphorane transition state of the enzyme-aspartyl-phosphate hydrolysis reaction. PMID:25883047

  3. Testing and Analysis of a Composite Non-Cylindrical Aircraft Fuselage Structure . Part II; Severe Damage

    NASA Technical Reports Server (NTRS)

    Przekop, Adam; Jegley, Dawn C.; Lovejoy, Andrew E.; Rouse, Marshall; Wu, Hsi-Yung T.

    2016-01-01

    The Environmentally Responsible Aviation Project aimed to develop aircraft technologies enabling significant fuel burn and community noise reductions. Small incremental changes to the conventional metallic alloy-based 'tube and wing' configuration were not sufficient to achieve the desired metrics. One airframe concept identified by the project as having the potential to dramatically improve aircraft performance was a composite-based hybrid wing body configuration. Such a concept, however, presented inherent challenges stemming from, among other factors, the necessity to transfer wing loads through the entire center fuselage section which accommodates a pressurized cabin confined by flat or nearly flat panels. This paper discusses a finite element analysis and the testing of a large-scale hybrid wing body center section structure developed and constructed to demonstrate that the Pultruded Rod Stitched Efficient Unitized Structure concept can meet these challenging demands of the next generation airframes. Part II of the paper considers the final test to failure of the test article in the presence of an intentionally inflicted severe discrete source damage under the wing up-bending loading condition. Finite element analysis results are compared with measurements acquired during the test and demonstrate that the hybrid wing body test article was able to redistribute and support the required design loads in a severely damaged condition.

  4. Arms race modeling: systematic analysis and synthesis. (Volumes I and II)

    SciTech Connect

    Anderton, C.H.

    1986-01-01

    In recent years there has been a significant proliferation of arms race models in journals and books across many disciplines. Numerous factors have been put forth as relevant by arms race modelers and diverse analytical and explanatory approaches have been employed. This indicates that arms race modeling can be advanced by a systematic analysis (review) and synthesis. This is the purpose of this thesis). Part I discusses the perspective, purposes, and organization of this thesis, definitions of arms race, and mathematical modeling as a tool of arms race research. Parts II-VI review in detail over 125 arms race models and numerous other defense determination models. Part VII synthesizes arms race modeling factors and approaches from the perspective of economics. Each side in an arms race is viewed as facing an economic choice problem of how to allocate scarce resources between defense and nondefense goods. Part VIII undertakes policy analysis using the models developed in Part VII. The three issues investigated are (1) nuclear-conventional substitutability in the European theater, (2) the Strategic Defense Initiative, and (3) the impact of arms races on outputs and factor rewards. Part IX discusses future research avenues related to arms race modeling.

  5. Multi-Function Waste Tank Facility thermal hydraulic analysis for Title II design

    SciTech Connect

    Cramer, E.R.

    1994-11-10

    The purpose of this work was to provide the thermal hydraulic analysis for the Multi-Function Waste Tank Facility (MWTF) Title II design. Temperature distributions throughout the tank structure were calculated for subsequent use in the structural analysis and in the safety evaluation. Calculated temperatures of critical areas were compared to design allowables. Expected operating parameters were calculated for use in the ventilation system design and in the environmental impact documentation. The design requirements were obtained from the MWTF Functional Design Criteria (FDC). The most restrictive temperature limit given in the FDC is the 200 limit for the haunch and dome steel and concrete. The temperature limit for the rest of the primary and secondary tanks and concrete base mat and supporting pad is 250 F. Also, the waste should not be allowed to boil. The tank geometry was taken from ICF Kaiser Engineers Hanford drawing ES-W236A-Z1, Revision 1, included here in Appendix B. Heat removal rates by evaporation from the waste surface were obtained from experimental data. It is concluded that the MWTF tank cooling system will meet the design temperature limits for the design heat load of 700,000 Btu/h, even if cooling flow is lost to the annulus region, and temperatures change very slowly during transients due to the high heat capacity of the tank structure and the waste. Accordingly, transients will not be a significant operational problem from the viewpoint of meeting the specified temperature limits.

  6. Analysis and control of the photon beam position at PLS-II

    PubMed Central

    Ko, J.; Kim, I.-Y.; Kim, C.; Kim, D.-T.; Huang, J.-Y.; Shin, S.

    2016-01-01

    At third-generation light sources, the photon beam position stability is a critical issue for user experiments. In general, photon beam position monitors are developed to detect the real photon beam position, and the position is controlled by a feedback system in order to maintain the reference photon beam position. At Pohang Light Source II, a photon beam position stability of less than 1 µm r.m.s. was achieved for a user service period in the beamline, where the photon beam position monitor is installed. Nevertheless, a detailed analysis of the photon beam position data was necessary in order to ensure the performance of the photon beam position monitor, since it can suffer from various unknown types of noise, such as background contamination due to upstream or downstream dipole radiation, and undulator gap dependence. This paper reports the results of a start-to-end study of the photon beam position stability and a singular value decomposition analysis to confirm the reliability of the photon beam position data. PMID:26917132

  7. Mass spectrometry and biochemical analysis of RNA polymerase II: targeting by protein phosphatase-1

    PubMed Central

    Jerebtsova, Marina; Klotchenko, Sergei A.; Artamonova, Tatiana O.; Ammosova, Tatiana; Washington, Kareem; Egorov, Vladimir V.; Shaldzhyan, Aram A.; Sergeeva, Maria V.; Zatulovskiy, Evgeny A.; Temkina, Olga A.; Petukhov, Mikhail G.; Vasin, Andrei V.; Khodorkovskii, Mikhail A.; Orlov, Yuri N.

    2011-01-01

    Transcription of eukaryotic genes is regulated by phosphorylation of serine residues of heptapeptide repeats of the carboxyterminal domain (CTD) of RNA polymerase II (RNAPII). We previously reported that protein phosphatase-1 (PP1) dephosphorylates RNAPII CTD in vitro and inhibition of nuclear PP1-blocked viral transcription. In this article, we analyzed the targeting of RNAPII by PP1 using biochemical and mass spectrometry analysis of RNAPII-associated regulatory subunits of PP1. Immunoblotting showed that PP1 co-elutes with RNAPII. Mass spectrometry approach showed the presence of U2 snRNP. Co-immunoprecipitation analysis points to NIPP1 and PNUTS as candidate regulatory subunits. Because NIPP1 was previously shown to target PP1 to U2 snRNP, we analyzed the effect of NIPP1 on RNAPII phosphorylation in cultured cells. Expression of mutant NIPP1 promoted RNAPII phosphorylation suggesting that the deregulation of cellular NIPP1/PP1 holoenzyme affects RNAPII phosphorylation and pointing to NIPP1 as a potential regulatory factor in RNAPII-mediated transcription. PMID:20941529

  8. America in World War II: An Analysis of History Textbooks from England, Japan, Sweden, and the United States

    ERIC Educational Resources Information Center

    Foster, Stuart; Nicholls, Jason

    2005-01-01

    This study examined how textbooks from England, Japan, Sweden, and the United States portray America's role in World War II. Analysis of the central story lines revealed that historical information purveyed to students in different nations varies considerably. Accordingly, U.S. textbooks emphasize the significant and pre-eminent role that the…

  9. Sequence analysis of bone morphogenetic protein receptor type II mRNA from ascitic and nonascitic commercial broilers.

    PubMed

    Cisar, C R; Balog, J M; Anthony, N B; Donoghue, A M

    2003-10-01

    Ascites syndrome, also known as pulmonary hypertension syndrome (PHS), is a common metabolic disorder in rapidly growing meat-type chickens. Environmental factors, such as cold, altitude, and diet, play significant roles in development of the disease, but there is also an important genetic component to PHS susceptibility. The human disease familial primary pulmonary hypertension (FPPH) is similar to PHS in broilers both genetically and physiologically. Several recent studies have shown that mutations in the bone morphogenetic protein receptor type II (BMPR2) gene are a cause of FPPH in humans. To determine whether mutations in the chicken BMPR2 gene play a similar role in PHS susceptibility, BMPR-II mRNA from ascitic and nonascitic commercial broilers were sequenced and compared with the published Leghorn chicken BMPR-II mRNA sequence. Fourteen single nucleotide polymorphisms (SNP) were identified in the commercial broiler BMPR-II mRNA. No mutations unique to ascites-susceptible broilers were present in the coding, 5' untranslated or 3' untranslated regions of BMPR-II mRNA. The twelve SNP present within the coding region of BMPR-II mRNA were synonymous substitutions and did not alter the BMPR-II protein sequence. In addition, analysis of BMPR2 gene expression by reverse transcriptase-PCR indicated that there were no differences in BMPR-II mRNA levels in ascitic and nonascitic birds. Therefore, it appears unlikely that mutations in the BMPR2 gene were responsible for susceptibility to PHS in these commercial broilers. PMID:14601724

  10. Synthetic hydroxyapatites doped with Zn(II) studied by X-ray diffraction, infrared, Raman and thermal analysis

    NASA Astrophysics Data System (ADS)

    Guerra-López, José R.; Echeverría, Gustavo A.; Güida, Jorge A.; Viña, Raúl; Punte, Graciela

    2015-06-01

    Calcium hydroxyapatite (CaHap) formation when different amounts of Zn(II) are present in the mother solution has been investigated by atomic absorption, infrared and Raman spectroscopies, X-ray diffraction and thermal analysis (DTA and TG). The studied samples have been synthesized at T=95 °C and pH 9 in air. The analysis of the results have shown that the pure CaHap sample crystallizes in the monoclinic form P21/b. Concentrations up to 20% of Zn(II) in the mother solution, equivalent to smaller concentrations in solid (up to 9.1% in wt), favor the formation of the hexagonal apatite, P63/m, while Zn(II) concentrations higher than 20% in solution help an amorphous phase development where vibrational spectra indicated coexistence of two phases: an apatite and ZnNH4PO4·H2O. Infrared data of thermal treated samples endorse that HPO42- ion had not been incorporated in Zn(II) doped samples during the synthesis process. Present results also allow to conclude that Zn(II) cation exhibits a preference to occupy the Ca2 site of the apatite structure and induces water adsorption and a small quantity of CO32- cation incorporation, leading to formation of a less crystalline Ca deficient apatite.

  11. SERVER DEVELOPMENT FOR NSLS-II PHYSICS APPLICATIONS AND PERFORMANCE ANALYSIS

    SciTech Connect

    Shen, G.; Kraimer, M.

    2011-03-28

    The beam commissioning software framework of NSLS-II project adopts a client/server based architecture to replace the more traditional monolithic high level application approach. The server software under development is available via an open source sourceforge project named epics-pvdata, which consists of modules pvData, pvAccess, pvIOC, and pvService. Examples of two services that already exist in the pvService module are itemFinder, and gather. Each service uses pvData to store in-memory transient data, pvService to transfer data over the network, and pvIOC as the service engine. The performance benchmarking for pvAccess and both gather service and item finder service are presented in this paper. The performance comparison between pvAccess and Channel Access are presented also. For an ultra low emittance synchrotron radiation light source like NSLS II, the control system requirements, especially for beam control are tight. To control and manipulate the beam effectively, a use case study has been performed to satisfy the requirement and theoretical evaluation has been performed. The analysis shows that model based control is indispensable for beam commissioning and routine operation. However, there are many challenges such as how to re-use a design model for on-line model based control, and how to combine the numerical methods for modeling of a realistic lattice with the analytical techniques for analysis of its properties. To satisfy the requirements and challenges, adequate system architecture for the software framework for beam commissioning and operation is critical. The existing traditional approaches are self-consistent, and monolithic. Some of them have adopted a concept of middle layer to separate low level hardware processing from numerical algorithm computing, physics modelling, data manipulating and plotting, and error handling. However, none of the existing approaches can satisfy the requirement. A new design has been proposed by introducing service

  12. POWTEX Neutron Diffractometer at FRM II - New Perspectives for In-Situ Rock Deformation Analysis

    NASA Astrophysics Data System (ADS)

    Walter, J. M.; Stipp, M.; Ullemeyer, K.; Klein, H.; Leiss, B.; Hansen, B. T.; Kuhs, W. F.

    2012-04-01

    In Geoscience quantitative texture analysis here defined as the quantitative analysis of the crystallographic preferred orientation (CPO), is a common tool for the investigation of fabric development in mono- and polyphase rocks, their deformation histories and kinematics. Bulk texture measurements also allow the quantitative characterisation of the anisotropic physical properties of rock materials. A routine tool to measure bulk sample volumes is neutron texture diffraction, as neutrons have large penetration capabilities of several cm in geological sample materials. The new POWTEX (POWder and TEXture) Diffractometer at the neutron research reactor FRM II in Garching, Germany is designed as a high-intensity diffractometer by groups from the RWTH Aachen, Forschungszentrum Jülich and the University of Göttingen. Complementary to existing neutron diffractometers (SKAT at Dubna, Russia; GEM at ISIS, UK; HIPPO at Los Alamos, USA; D20 at ILL, France; and the local STRESS-SPEC and SPODI at FRM II) the layout of POWTEX is focused on fast time-resolved experiments and the measurement of larger sample series as necessary for the study of large scale geological structures. POWTEX is a dedicated beam line for geoscientific research. Effective texture measurements without sample tilting and rotation are possible firstly by utilizing a range of neutron wavelengths simultaneously (Time-of-Flight technique) and secondly by the high detector coverage (9.8 sr) and a high flux (~1 - 107 n/cm2s) at the sample. Furthermore the instrument and the angular detector resolution is designed also for strong recrystallisation textures as well as for weak textures of polyphase rocks. These instrument characteristics allow in-situ time-resolved texture measurements during deformation experiments on rocksalt, ice and other materials as large sample environments will be implemented at POWTEX. The in-situ deformation apparatus is operated by a uniaxial spindle drive with a maximum axial load of

  13. Environmentally compatible hand wipe cleaning solvents

    NASA Technical Reports Server (NTRS)

    Clayton, Catherine P.; Kovach, Michael P.

    1995-01-01

    Several solvents of environmental concern have previously been used for hand wipe cleaning of SRB surfaces, including 1,1,1-trichloroethane, perchloroethylene, toluene, xylene, and MEK. USBI determined the major types of surfaces involved, and qualification requirements of replacement cleaning agents. Nineteen environmentally compatible candidates were tested on 33 material substrates with 26 types of potential surface contaminants, involving over 7,000 individual evaluations. In addition to the cleaning performance evaluation, bonding, compatibility, and corrosion tests were conducted. Results showed that one cleaner was not optimum for all surfaces. In most instances, some of the candidates cleaned better than the 1,1,1-trichloroethane baseline control. Aqueous cleaners generally cleaned better, and were more compatible with nonmetallic materials, such as paints, plastics, and elastomers. Organic base cleaners were better on metal surfaces. Five cleaners have been qualified and are now being implemented in SRB hand wipe cleaning operations.

  14. Materials Compatibility in High Test Hydrogen Peroxide

    NASA Technical Reports Server (NTRS)

    Gostowski, Rudy

    1999-01-01

    Previous ratings of the compatibility of high test hydrogen peroxide (HTP) with materials are not adequate for current needs. The goal of this work was to develop a new scheme of evaluation of compatibility of HTP with various materials. Procedures were developed to enrich commercially available hydrogen peroxide to 90% concentration and to assay the product. Reactivity testing, accelerated aging of materials and calorimetry studies were done on HTP with representative metallic and non-metallic materials. It was found that accelerated aging followed by concentration determination using refractive index effectively discriminated between different Class 2 metallic materials. Preliminary experiments using Differential Scanning Calorimetry (DSC) suggest that a calorimetry experiment is the most sensitive means to assay the compatibility of HTP with materials.

  15. Fusion reactor breeder material safety compatibility studies

    SciTech Connect

    Jeppson, D.W.; Cohen, S.; Muhlestein, L.D.

    1983-09-01

    Tritium breeder material selection for fusion reactors is strongly influenced by the desire to minimize safety and environmental concerns. Breeder material safety compatibility studies are being conducted to identify and characterize breeder-coolant-material interactions under postulated reactor accident conditions. Recently completed scoping compatibility tests indicate the following. 1. Ternary oxides (LiAlO/sub 2/, Li/sub 2/ZrO/sub 3/, Li/sub 2/SiO/sub 3/, Li/sub 4/SiO/sub 4/, and LiTiO/sub 3/) at postulated blanket operating temperatures are chemically compatible with water coolant, while liquid lithium and Li/sub 7/Pb/sub 2/ reactions with water generate heat, aerosol, and hydrogen. 2. Lithium oxide and 17Li-83Pb alloy react mildly with water requiring special precautions to control hydrogen release. 3. Liquid lithium reacts substantially, while 17Li83Pb alloy reacts mildly with concrete to produce hydrogen. 4. Liquid lithium-air reactions may present some major safety concerns. Additional scoping tests are needed, but the ternary oxides, lithium oxide, and 17Li-83Pb have definite safety advantages over liquid lithium and Li/sub 7/Pb/sub 2/. The ternary oxides present minimal safetyrelated problems when used with water as coolant, air or concrete; but they do require neutron multipliers, which may have safety compatibility concerns with surrounding materials. The combined favorable neutronics and minor safety compatibility concerns of lithium oxide and 17Li-83Pb make them prime candidates as breeder materials. Current safety efforts are directed toward assessing the compatibility of lithium oxide and the lithium-lead alloy with coolants and other materials.

  16. Micro-Compatibility Testing of Polysulfone

    SciTech Connect

    Gregg, H; Harvey, C; Maxwell, R; Vance, A

    2004-09-28

    Polysulfone has many useful properties, and its compatibility with other materials is of interest. It is a tough, rigid, high-strength thermoplastic that maintains its properties over a wide temperature range. It is chemically resistant to mineral acids and alkali and moderately resistant to hydrocarbon oils; however, it is not resistant to polar organic solvents such as ketones, chlorinated hydrocarbons and aromatic hydrocarbons. Micro-compatibility experiments were initiated to determine possible detrimental interactions in a sealed environment between polysulfone components and a number of other organic species.

  17. Electromagnetic Compatibility for the Space Shuttle

    NASA Technical Reports Server (NTRS)

    Scully, Robert C.

    2004-01-01

    This slide presentation reviews the Space Shuttle electromagnetic compatibility (EMC). It includes an overview of the design of the shuttle with the areas that are of concern for the electromagnetic compatibility. It includes discussion of classical electromagnetic interference (EMI) and the work performed to control the electromagnetic interference. Another area of interest is electrostatic charging and the threat of electrostatic discharge and the attempts to reduce damage to the Shuttle from these possible hazards. The issue of electrical bonding is als reviewed. Lastly the presentation reviews the work performed to protect the shuttle from lightning, both in flight and on the ground.

  18. Area 3, SRC-II coal slurry preheater studies report for the technical data analysis program

    SciTech Connect

    Not Available

    1984-08-01

    This report reviews the raw data gathered from the Preheater B test runs at Ft. Lewis, and also the Preheater B results presented in the Solvent Refined Coal (SRC) Process Final Report, Volumes 1 and 2 of Slurry Preheater Design, SRC-II Process and the Ft. Lewis Slurry Preheater Data Analysis, 1 1/2 Inch Coil by Gulf Science and Technology Corporation of Pittsburgh, Pennsylvania. attempts were made to correlate several variables not previously considered with slurry viscosity and thermal conductivity. Only partial success was realized. However, in the process of attempting to correlate these variables an understanding of why some variables could not be correlated was achieved. An attempt was also made, using multiple linear regression, to correlate coal slurry viscosity and thermal conductivity with several independent variables among which were temperature, coal concentration, total solids, coal type, slurry residence time, shear rate, and unit size. The final correlations included some, but not all, of these independent variables. This report is not a stand alone document and should be considered a supplement to work already done. It should be read in conjunction with the reports referenced above.

  19. Safety analysis report for the TRUPACT-II shipping package (condensed version). Volume 2, Rev. 14

    SciTech Connect

    1994-10-01

    This appendix determines the effective G values for payload shipping categories of contact handled transuranic (CH-TRU) waste materials, based on the radiolytic G values for waste materials that are discussed in detail in Appendix 3.6.8 of the Safety Analysis Report for the TRUPACT-II Shipping Package. The effective G values take into account self-absorption of alpha decay energy inside particulate contamination and the fraction of energy absorbed by nongas-generating materials. As described in Appendix 3.6.8, an effective G value, G{sub eff}, is defined by: G{sub eff} - {Sigma}{sub M} (F{sub M} x G{sub M}) F{sub M}-fraction of energy absorbed by material maximum G value for a material where the sum is over all materials present inside a waste container. The G value itself is determined primarily by the chemical properties of the material and its temperature. The value of F is determined primarily by the size of the particles containing the radionuclides, the distribution of radioactivity on the various materials present inside the waste container, and the stopping distance of alpha particles in air, in the waste materials, or in the waste packaging materials.

  20. A PCA approach to population analysis: with application to a Phase II depression trial.

    PubMed

    Marostica, Eleonora; Russu, Alberto; Gomeni, Roberto; Zamuner, Stefano; De Nicolao, Giuseppe

    2013-04-01

    For psychiatric diseases, established mechanistic models are lacking and alternative empirical mathematical structures are usually explored by a trial-and-error procedure. To address this problem, one of the most promising approaches is an automated model-free technique that extracts the model structure directly from the statistical properties of the data. In this paper, a linear-in-parameter modelling approach is developed based on principal component analysis (PCA). The model complexity, i.e. the number of components entering the PCA-based model, is selected by either cross-validation or Mallows' Cp criterion. This new approach has been validated on both simulated and clinical data taken from a Phase II depression trial. Simulated datasets are generated through three parametric models: Weibull, Inverse Bateman and Weibull-and-Linear. In particular, concerning simulated datasets, it is found that the PCA approach compares very favourably with some of the popular parametric models used for analyzing data collected during psychiatric trials. Furthermore, the proposed method performs well on the experimental data. This approach can be useful whenever a mechanistic modelling procedure cannot be pursued. Moreover, it could support subsequent semi-mechanistic model building. PMID:23504512

  1. Crystal structures and Hirshfeld surface analysis calculations of mercury(II) complexes with a diiminopyridine ligand

    NASA Astrophysics Data System (ADS)

    Hosseini, Seyed Ali; Mahmoudi, Ghodrat; Garczarek, Piotr; Hazendonk, Paul; Abedi, Marjan; Servati Gargari, Masoumeh

    2016-02-01

    The reaction of a diiminopyridine ligand, N,N‧-bis(phenyl(pyridin-2-yl)methylene)propane-1,3-diamine (L), with mercury(II) salts gave two complexes namely [Hg(L)Cl]·0.5[Hg2Cl6] (1) and [Hg(L)(μ-I)HgI3] (2), which were characterized by XRD, NMR and FTIR. The crystal structure of 1 consists of discrete units of [Hg(L)CI]+cations and [Hg2C16]2- anions in the ratio 2:1. The coordination of mercury in the cation is approximately square pyramidal (sp), the metal center is chelated in a tetradentate manner by the ligand and further coordinated by one chlorine atom. In 2 the packing can be described as units of μ-I-connected square pyramidal (sp) and tetrahedral Hg complexes. The sp coordination around the metal atom is defined by the N4 donor set of the ligand and one bridging iodide. The hydrogen-chlorine donor-accepter interactions in 1 stabilize an infinite 1-D chain; however, such interactions were not observed in 2. Analysis of their Hirshfeld surfaces indicates that the molecules in 1 and 2 are packed predominately by means of van der Waals forces, 'edge to face' aromatic ring packing and weak C-H··X donor-acceptor interactions.

  2. Update on the Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II): statistical analysis plan

    PubMed Central

    2012-01-01

    Background Previous studies had suggested that the outcome for patients with spontaneous lobar intracerebral haemorrhage (ICH) and no intraventricular haemorrhage (IVH) might be improved with early evacuation of the haematoma. The Surgical Trial in Lobar Intracerebral Haemorrhage (STICH II) set out to establish whether a policy of earlier surgical evacuation of the haematoma in selected patients with spontaneous lobar ICH would improve outcome compared to a policy of initial conservative treatment. It is an international, multi-centre, prospective randomised parallel group trial of early surgery in patients with spontaneous lobar ICH. Outcome is measured at six months via a postal questionnaire. Results Recruitment to the study began on 27 November 2006 and closed on 15 August 2012 by which time 601 patients had been recruited. The protocol was published in Trials (http://www.trialsjournal.com/content/12/1/124/). This update presents the analysis plan for the study without reference to the unblinded data. The trial data will not be unblinded until after follow-up is completed in early 2013. The main trial results will be presented in spring 2013 with the aim to publish in a peer-reviewed journal at the same time. Conclusion The data from the trial will provide evidence on the benefits and risks of early surgery in patients with lobar ICH. Trial registration ISRCTN: ISRCTN22153967 PMID:23171588

  3. A comparative molecular field analysis and molecular modelling studies on pyridylimidazole type of angiotensin II antagonists.

    PubMed

    Yoo, S E; Kim, S K; Lee, S H; Yi, K Y; Lee, D W

    1999-12-01

    A large number of compounds known as "AII (Angiotensin II) antagonists" have been developed for the treatment of various heart diseases such as hypertension, congestive heart failure, and chronic renal failure. Most of the currently known AII receptor antagonists share a similar chemical structure, consisting of nitrogen atoms, a lipophilic alkyl side chain and an acidic group. As a new series, we have designed and synthesized various pyridylimidazole derivatives. In this report we would like to discuss the structure-activity relationship of these series of compounds using the comparative molecular field analysis (CoMFA) methods. We could come up with a good CoMFA model (cross-validated and conventional r2 values equal to 0.702 and 0.991, respectively) and the validity of the model was confirmed by synthesizing and measuring their biological activity of additional 6 compounds suggested by the model. This result provides additional information on the structural requirement for structurally diverse group of AII receptor antagonists. PMID:10658603

  4. Identification of Type II Interferon Receptors in Geese: Gene Structure, Phylogenetic Analysis, and Expression Patterns

    PubMed Central

    Zhou, Hao; Chen, Shun; Qi, Yulin; Zhou, Qin; Wang, Mingshu; Jia, Renyong; Zhu, Dekang; Liu, Mafeng; Liu, Fei; Chen, Xiaoyue; Cheng, Anchun

    2015-01-01

    Interferon γ receptor 1 (IFNGR1) and IFNGR2 are two cell membrane molecules belonging to class II cytokines, which play important roles in the IFN-mediated antiviral signaling pathway. Here, goose IFNGR1 and IFNGR2 were cloned and identified for the first time. Tissue distribution analysis revealed that relatively high levels of goose IFNγ mRNA transcripts were detected in immune tissues, including the harderian gland, cecal tonsil, cecum, and thymus. Relatively high expression levels of both IFNGR1 and IFNGR2 were detected in the cecal tonsil, which implicated an important role of IFNγ in the secondary immune system of geese. No specific correlation between IFNγ, IFNGR1, and IFNGR2 expression levels was observed in the same tissues of healthy geese. IFNγ and its cognate receptors showed different expression profiles, although they appeared to maintain a relatively balanced state. Furthermore, the agonist R848 led to the upregulation of goose IFNγ but did not affect the expression of goose IFNGR1 or IFNGR2. In summary, trends in expression of goose IFNγ and its cognate receptors showed tissue specificity, as well as an age-related dependency. These findings may help us to better understand the age-related susceptibility to pathogens in birds. PMID:26345454

  5. POWTEX Neutron Diffractometer at FRM II - New Perspectives in Rock Deformation and Recrystallisation Analysis

    NASA Astrophysics Data System (ADS)

    Walter, J. M.; Stipp, M.; Ullemeyer, K.; Klein, H.; Leiss, B.; Hansen, B.; Kuhs, W. F.

    2011-12-01

    Neutron diffraction has become a routine method in Geoscience for the quantitative analysis of crystallographic preferred orientations (CPOs) and for (experimental) powder diffraction. Quantitative texture analysis is a common tool for the investigation of fabric development in mono- and polyphase rocks, their deformation histories and kinematics. Furthermore the quantitative characterization of anisotropic physical properties by bulk texture measurements can be achieved due to the high penetration capabilities of neutrons. To cope with increasing needs for beam time at neutron diffraction facilities with the corresponding technical characteristics and equipment, POWTEX (POWder and TEXture Diffractometer) is designed as a high-intensity diffractometer at the neutron research reactor FRM II in Garching, Germany by groups from the RWTH Aachen, Forschungszentrum Jülich and the University of Göttingen. Complementary to existing neutron diffractometers (SKAT at Dubna, Russia; GEM at ISIS, UK; HIPPO at Los Alamos, USA; D20 at ILL, France; and the local STRESS-SPEC and SPODI at FRM II) the layout of POWTEX is focused on fast (texture) measurements for either time-resolved experiments or the measurement of larger sample series as necessary for the study of large scale geological structures. By utilizing a range of neutron wavelengths simultaneously (TOF-technique), a high flux (~1 x 107 n/cm2s) and a high detector coverage ( 9.8 sr) effective texture measurements without sample tilting and rotation are possible. Furthermore the instrument and the angular detector resolution is sufficient for strong recrystallisation textures as well as weak textures of polyphase rocks. Thereby large sample environments will be implemented at POWTEX allowing in-situ time-resolved texture measurements during deformation experiments on rocksalt, ice and other materials. Furthermore a furnace for 3D-recrystallisation analysis of single grains will be realized complementary to the furnace

  6. Mitochondrial DNA polymorphisms in Italy. II. Molecular analysis of new and rare morphs from Sardinia and Rome.

    PubMed

    Santachiara Benerecetti, A S; Scozzari, R; Semino, O; Torroni, A; Brega, A; Wallace, D C

    1988-01-01

    A molecular analysis of morphs found in a previous survey of mtDNA restriction enzyme polymorphisms in Italy revealed that different site changes can give similar patterns and that the same mutation can yield variant morphs for apparently unrelated enzymes. 1. Alternative site variations were found to yield restriction fragment patterns resembling HpaI morph 4, HaeII morph 5 and AvaII morph 2. 2. A strong association was observed between the BamHI morph 3 (gain of site a) and the AvaII morph 9 and its derivatives (loss of site d). This association appears to result from an A to G transition at base pair (bp) 13,368 which simultaneously creates a new BamHI site and abolishes an AvaII site. On the other hand, the loss of the AvaII site d, which in Italy was only found in the above-mentioned association, does not always produce a new BamHI site, as observed in other Caucasian groups. Similarly, the BamHI morph 2 (gain of site b) was always found to be associated with AvaII morphs lacking site f. An A to G transition at bp 16,391 was shown to account for both changes. As in the previous case, the converse is not true. Hence, these data show that AvaII sites d and f were lost in more than one way and one of these seems to be typical of Caucasians. 3. The variation producing BamHI-3/AvaII-9 and derivatives is preferentially associated with MspI morph 4 but this is not a product of a shared mutation. Hence, this association must be the result of the linkage disequilibrium due to the maternal inheritance of mtDNA and lack of recombination. 4. The high frequency of the combination BamHI-3/AvaII-9 and derivatives with MspI-4 found in Italy (29 subjects out of 229 analysed) can best be explained by diffusion of the relevant haplotype rather than by repeated mutational events. 5. The phylogeny trees of all mtDNA morphs so far described and of mtDNA types in Caucasians have been revised taking into account both the inter- and the intra-morph heterogeneity detected by this

  7. 60-Day waste compatibility safety issues and final results for AY-102 grab samples

    SciTech Connect

    Nuzum, J.L.

    1997-01-31

    Four grab samples (2AY-96-15, 2AY-96-16, 2AY-96-17, and 2AY-96-18) were taken from Riser 15D of Tank 241-AY-102 on October 8, 1996, and received by 222-S Laboratory on October 8, 1996. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) in support of the Waste Compatibility Program. No notifications were required based on sample results.

  8. 60-day waste compatibility safety issues and final results for TX-244 grab samples

    SciTech Connect

    Nuzum, J.L., Fluor Daniel Hanford

    1997-02-05

    Three grab samples (244-TX-96-1, 244-TX-96-2, and 244-TX-96-3) were taken from Riser 8 of Tank 241-TX-244 on October 18, 1996, and received by 222-S Laboratory on October 18, 1996. These samples were analyzed in accordance with Compatibility Grab Sampling and Analysis Plan (TSAP) and Data Quality Objectives for Tank Farms Waste Compatibility Program (DQO) in support ofthe Waste Compatibility Program. Notifications were made in accordance with TSAP for pH and OH- analyses. Upon further review, the pH notification was deemed unnecessary, as the notification limit did not apply to this tank.

  9. Water/sand flooded and immersed critical experiment and analysis performed in support of the TOPAZ-II safety program

    SciTech Connect

    Glushkov, E.S.; Ponomarev-Stepnoi, N.N.; Bubelev, V.G.; Garin, V.P.; Gomin, E.A.; Kompanietz, G.V.; Krutov, A.M.; Lobynstev, V.A.; Maiorov, L.V.; Polyakov, D.N.; Chunyaev, E.I.; Marshall, A.C.; Sapir, J.L.; Pelowitz, D.B.

    1995-01-20

    Presented is a brief description of the Narciss-M2 critical assemblies, which simulate accidental water/wet-sand immersion of the TOPAZ-II reactor as well as water-flooding of core cavities. Experimental results obtained from these critical assemblies, including experiments with several fuel elements removed from the core, are shown. These configurations with several extracted fuel elements simulate a proposed fuel-out anticriticality-device modification to the TOPAZ-II reactor. Preliminary computational analysis of these experiments using the Monte Carlo neutron-transport method is outlined. Nuclear criticality safety of the TOPAZ-II reactor with an incorporated anticriticality unit is demonstrated. {copyright} {ital 1995} {ital American} {ital Institute} {ital of} {ital Physics}

  10. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5... 1, the Compatibility Chart....

  11. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5... 1, the Compatibility Chart....

  12. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO... 1, the Compatibility Chart....

  13. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (CG-ENG-5... 1, the Compatibility Chart....

  14. 46 CFR 150.150 - Exceptions to the compatibility chart.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Exceptions to the compatibility chart. 150.150 Section... CARGOES COMPATIBILITY OF CARGOES § 150.150 Exceptions to the compatibility chart. The Commandant (G-MSO... 1, the Compatibility Chart....

  15. Analysis of TOPAZ II and SPACE-R space nuclear power plants using a modified thermionic model

    SciTech Connect

    Habedank, O.D.

    1993-03-01

    Models based on the TDS thermionic diode model were developed for the TOPAZ II and SPACE-R nuclear power systems. Due to computer code limitations inherent in the TDS model, only the TOPAZ II system model ran successfully. Several parameter studies were conducted on the TOPAZ II model. These studies determined system performance and efficiency while varying the following: (1) the coolant flow inlet temperatures; (2) the rate of coolant temperature change; (3) the power profile of the core; and (4) the cesium reservoir temperature. Analysis of the results indicate that the model accurately represented the TOPAZ II system, underestimating published data by 10%. Coolant flow parameter studies indicate that raising coolant flow temperatures up to 100 K higher increases system power by put to 5%. Additional increases in temperature result in gradual performance degradation. Varying the axial power profile of the core from the actual peaked profile to a flat profile results in a negligible 0.3% change in total system performance. The peaked profile used in TOPAZ II produces the highest system efficiency of all the profiles modeled. The cesium pressure study indicates that the system is operating above optimum cesium pressure and that system performance is strongly dependent on cesium pressure. Increasing cesium reservoir temperature above design temperature by 30 K decreases system efficiency by 30%.

  16. Neutron irradiation and compatibility testing of Li 2O

    NASA Astrophysics Data System (ADS)

    Porter, D. L.; Krsul, J. R.; Laug, M. T.; Walters, L. C.; Tetenbaum, M.

    1984-05-01

    A study was made of the neutron irradiation behavior of 6Li-enriched Li 2O in EBR-II. In addition, a stress corrosion study was performed ex-reactor to test the compatibility of Li 2O with a variety of stainless steels. The irradiation tests showed that tritium and helium retention in the Li 2O (˜ 89% dense) lessened with neutron exposure, and the retentions appear to approach a steady-state after ˜ 1% 6Li burnup. The stress corrosion studies, using 316 stainless steel (Ti-modified) and a 35% Ni alloy, showed that stress does not enhance the corrosion, and that dry Li 2O is not significantly corrosive, the LiOH content producing the corrosive effects. Corrosion, in general, was not severe because a passivation in sealed capsules seemed to occur after a time which greatly reduced corrosion rates.

  17. A model of the immune-compatibility using the install problem in computer science

    NASA Astrophysics Data System (ADS)

    Díaz, Felipe

    2014-05-01

    We simulate the immune compatibility using the Install Problem: The idea is to define a Boolean variable for each antibody. This variable is true if the antibody must be in the immune system. The Install Problem refers to the incompatibility that some programs may have with an specific operative system making it impossible to be installed. The analysis was implemented using SMT-solvers, specifically Z3, and the code was wrote using the commands "DependsOn", "Conflict" and "Compatibility_check", making it possible to check the antibody compatibility. The programming languages used to build up the code were Z3-Python and Z3-SMT-Lib. The results can be used in systems biology and in the analysis of immunological therapies. As future line of research it could be developed a more complex algorithm to verify the immunological compatibility.

  18. Compatibility and Outgassing Studies for Directed Stockpile Work (FY05)

    SciTech Connect

    Alviso, C; Harvey, C; Vance, A

    2005-11-23

    Compatibility and outgassing studies of non-nuclear materials were carried out in support of the W80 Life Extension Program. These studies included small-scale laboratory experiments as well as participation in Sandia's Materials Aging and Compatibility test (MAC-1). Analysis of the outgassing signature of removable epoxy foam (REF) revealed unusually high levels of volatile organic compounds in the material. REF was replaced with the polyurethane PMDI. Laboratory compatibility tests of high priority materials were performed and revealed incompatibilities between Viton A (LX-07 binder) and syntactic polysulfide as well as Viton A and REF. With the removal of REF from the system, the incompatibility with Viton A is not an issue. In the case of the viton/polysulfide, both of these materials have a history of reliability in the stockpile, and the observed results, while scientifically interesting, appear to be a laboratory anomaly. Participation in the MAC-1 test led to a detailed study of Viton A degradation. At elevated temperatures up to 70 C, the Viton A samples darkened and exhibited increased crosslinking. Laboratory experiments were pursued to correlate the observed changes to exposure to specific compounds that were present in the MAC-1 canister atmospheres. Exposure to siloxanes resulted in changes similar to those seen in the MAC-1 samples. Knowledge gained from the MAC-1 test will be applied to the upcoming MAC-2 test planned for FY06. Finally, the suitability of isotopically labeled nitrogen fill gas ({sup 15}N{sub 2}) was addressed. This gas will behave as standard nitrogen with no compatibility concerns expected.

  19. Compatibility of Motion Facilitates Visuomotor Synchronization

    ERIC Educational Resources Information Center

    Hove, Michael J.; Spivey, Michael J.; Krumhansl, Carol L.

    2010-01-01

    Prior research indicates that synchronized tapping performance is very poor with flashing visual stimuli compared with auditory stimuli. Three finger-tapping experiments compared flashing visual metronomes with visual metronomes containing a spatial component, either compatible, incompatible, or orthogonal to the tapping action. In Experiment 1,…

  20. Catholic Educator Perceptions about Brain Compatible Instruction

    ERIC Educational Resources Information Center

    Koenen, Amie

    2009-01-01

    This document reports the findings of a doctoral project regarding the perceptions held by administrators and teachers of comprehensive Catholic schools in one Midwestern diocese. With the recent explosion of research in the area of the brain and brain compatible instruction it is valuable to know and understand the perceptions held by current…

  1. 9 CFR 3.7 - Compatible grouping.

    Code of Federal Regulations, 2011 CFR

    2011-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.7 Compatible grouping. Dogs and cats that are housed...; (b) Any dog or cat exhibiting a vicious or overly aggressive disposition must be housed...

  2. 9 CFR 3.7 - Compatible grouping.

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.7 Compatible grouping. Dogs and cats that are housed...; (b) Any dog or cat exhibiting a vicious or overly aggressive disposition must be housed...

  3. 9 CFR 3.7 - Compatible grouping.

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.7 Compatible grouping. Dogs and cats that are housed...; (b) Any dog or cat exhibiting a vicious or overly aggressive disposition must be housed...

  4. 9 CFR 3.7 - Compatible grouping.

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.7 Compatible grouping. Dogs and cats that are housed...; (b) Any dog or cat exhibiting a vicious or overly aggressive disposition must be housed...

  5. 9 CFR 3.7 - Compatible grouping.

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... WELFARE STANDARDS Specifications for the Humane Handling, Care, Treatment, and Transportation of Dogs and Cats 1 Animal Health and Husbandry Standards § 3.7 Compatible grouping. Dogs and cats that are housed...; (b) Any dog or cat exhibiting a vicious or overly aggressive disposition must be housed...

  6. Electromagnetic compatibility in nuclear power plants

    SciTech Connect

    Cirillo, J.; Prussel, M.

    1986-02-01

    EMC (electromagnetic compatibility) is being largely ignored in the design of nuclear power instrumentation and control systems. As a result, EMI (electromagnetic interference) is causing costly startup delays and spurious reactor trips. This paper describes existing problems, basic causes, and approaches to their solutions.

  7. The mitonuclear compatibility hypothesis of sexual selection.

    PubMed

    Hill, Geoffrey E; Johnson, James D

    2013-10-01

    Why females assess ornaments when choosing mates remains a central question in evolutionary biology. We hypothesize that the imperative for a choosing female to find a mate with nuclear oxidative phosphorylation (OXPHOS) genes that are compatible with her mitochondrial OXPHOS genes drives the evolution of ornaments. Indicator traits are proposed to signal the efficiency of OXPHOS function thus enabling females to select mates with nuclear genes that are compatible with maternal mitochondrial genes in the formation of OXPHOS complexes. Species-typical pattern of ornamentation is proposed to serve as a marker of mitochondrial type ensuring that females assess prospective mates with a shared mitochondrial background. The mitonuclear compatibility hypothesis predicts that the production of ornaments will be closely linked to OXPHOS pathways, and that sexual selection for compatible mates will be strongest when genes for nuclear components of OXPHOS complexes are Z-linked. The implications of this hypothesis are that sexual selection may serve as a driver for the evolution of more efficient cellular respiration. PMID:23945683

  8. [MRI compatibility of deep brain stimulator].

    PubMed

    Zhang, Yujing

    2013-07-01

    Deep brain stimulation (DBS) therapy develops rapidly in clinical application. The structures of deep brain stimulator and magnetic resonance imaging (MRI) equipment are introduced, the interactions are analyzed, and the two compatible problems of radio frequency (RF) heating and imaging artifact are summarized in this paper. PMID:24195387

  9. Compatibility Issues Affecting Information Systems and Services.

    ERIC Educational Resources Information Center

    Lancaster, F. Wilfrid; Smith, Linda C.

    This UNISIST publication discusses issues related to the compatibility and standardization of bibliograpic records, index languages, software, hardware, and other information systems and services. Following an executive summary, definitions of terms, and other introductory material, existing information systems with common standards are briefly…

  10. Brain-Compatible Assessments. Second Edition

    ERIC Educational Resources Information Center

    Ronis, Diane L.

    2007-01-01

    Diane Ronis, a recognized expert in brain-compatible learning and assessment, goes beyond the world of standardized testing to show educators how to build and use targeted assessments based on the latest neuroscientific research. Updated to reflect recent findings about how the brain learns, this book provides readers with revised tools for…

  11. 40 CFR 280.32 - Compatibility.

    Code of Federal Regulations, 2012 CFR

    2012-07-01

    ... 40 Protection of Environment 28 2012-07-01 2012-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL STANDARDS AND CORRECTIVE ACTION REQUIREMENTS FOR OWNERS AND OPERATORS OF UNDERGROUND STORAGE TANKS...

  12. 40 CFR 280.32 - Compatibility.

    Code of Federal Regulations, 2011 CFR

    2011-07-01

    ... 40 Protection of Environment 27 2011-07-01 2011-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL STANDARDS AND CORRECTIVE ACTION REQUIREMENTS FOR OWNERS AND OPERATORS OF UNDERGROUND STORAGE TANKS...

  13. 40 CFR 280.32 - Compatibility.

    Code of Federal Regulations, 2010 CFR

    2010-07-01

    ... 40 Protection of Environment 26 2010-07-01 2010-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL STANDARDS AND CORRECTIVE ACTION REQUIREMENTS FOR OWNERS AND OPERATORS OF UNDERGROUND STORAGE TANKS...

  14. 40 CFR 280.32 - Compatibility.

    Code of Federal Regulations, 2014 CFR

    2014-07-01

    ... 40 Protection of Environment 27 2014-07-01 2014-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL STANDARDS AND CORRECTIVE ACTION REQUIREMENTS FOR OWNERS AND OPERATORS OF UNDERGROUND STORAGE TANKS...

  15. 40 CFR 280.32 - Compatibility.

    Code of Federal Regulations, 2013 CFR

    2013-07-01

    ... 40 Protection of Environment 28 2013-07-01 2013-07-01 false Compatibility. 280.32 Section 280.32 Protection of Environment ENVIRONMENTAL PROTECTION AGENCY (CONTINUED) SOLID WASTES (CONTINUED) TECHNICAL STANDARDS AND CORRECTIVE ACTION REQUIREMENTS FOR OWNERS AND OPERATORS OF UNDERGROUND STORAGE TANKS...

  16. 78 FR 73085 - Mission Compatibility Evaluation Process

    Federal Register 2010, 2011, 2012, 2013, 2014

    2013-12-05

    ... Office of the Secretary 32 CFR Part 211 Mission Compatibility Evaluation Process AGENCY: Office of the... with other proposal review processes not included in section 358, such as those applied by the Bureau... interim final rule in the Federal Register on October 20, 2011, at 76 FR 65112. The public comment...

  17. 76 FR 65112 - Mission Compatibility Evaluation Process

    Federal Register 2010, 2011, 2012, 2013, 2014

    2011-10-20

    ... of the Secretary 32 CFR Part 211 Mission Compatibility Evaluation Process AGENCY: Office of the Under... rule deal with other clearance processes not included in section 358, such as those applied by the... participation of DoD in the Federal Aviation Administration's process under 49 ] U.S.C. 44718 to the...

  18. The mitonuclear compatibility hypothesis of sexual selection

    PubMed Central

    Hill, Geoffrey E.; Johnson, James D.

    2013-01-01

    Why females assess ornaments when choosing mates remains a central question in evolutionary biology. We hypothesize that the imperative for a choosing female to find a mate with nuclear oxidative phosphorylation (OXPHOS) genes that are compatible with her mitochondrial OXPHOS genes drives the evolution of ornaments. Indicator traits are proposed to signal the efficiency of OXPHOS function thus enabling females to select mates with nuclear genes that are compatible with maternal mitochondrial genes in the formation of OXPHOS complexes. Species-typical pattern of ornamentation is proposed to serve as a marker of mitochondrial type ensuring that females assess prospective mates with a shared mitochondrial background. The mitonuclear compatibility hypothesis predicts that the production of ornaments will be closely linked to OXPHOS pathways, and that sexual selection for compatible mates will be strongest when genes for nuclear components of OXPHOS complexes are Z-linked. The implications of this hypothesis are that sexual selection may serve as a driver for the evolution of more efficient cellular respiration. PMID:23945683

  19. External audio for IBM-compatible computers

    NASA Technical Reports Server (NTRS)

    Washburn, David A.

    1992-01-01

    Numerous applications benefit from the presentation of computer-generated auditory stimuli at points discontiguous with the computer itself. Modification of an IBM-compatible computer for use of an external speaker is relatively easy but not intuitive. This modification is briefly described.

  20. Preparation of small bio-compatible microspheres

    NASA Technical Reports Server (NTRS)

    Rembaum, Alan (Inventor); Yen, Shiao-Ping S. (Inventor); Dreyer, William J. (Inventor)

    1979-01-01

    Small, round, bio-compatible microspheres capable of covalently bonding proteins and having a uniform diameter below about 3500 A are prepared by substantially instantaneously initiating polymerization of an aqueous emulsion containing no more than 35% total monomer including an acrylic monomer substituted with a covalently bondable group such a hydroxyl, amino or carboxyl and a minor amount of a cross-linking agent.

  1. Instant Print-Braille Compatibility with COBRA.

    ERIC Educational Resources Information Center

    Durre, Ingeborg K.; Durre, Imke

    1999-01-01

    Describes an eight-dot computer Braille notation, COBRA, with integrated mathematical and scientific notation that achieves immediate print-Braille compatibility through one-to-one representation of letters and other characters. Text can be entered from the Braille or the Qwerty Keyboard and can be viewed simultaneously on the Braille display and…

  2. Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships.

    PubMed

    Bonaventure, J; Cohen-Solal, L; Ritvaniemi, P; Van Maldergem, L; Kadhom, N; Delezoide, A L; Maroteaux, P; Prockop, D J; Ala-Kokko, L

    1995-05-01

    Two different mutations were found in two unrelated probands with lethal chondrodysplasias, one with achondrogenesis type II and the other with the less severe phenotype of hypochondrogenesis. The mutations in the COL2A1 gene were identified by denaturing gradient gel electrophoresis analysis of genomic DNA followed by dideoxynucleotide sequencing and restriction site analysis. The proband with achondrogenesis type II had a heterozygous single-base mutation that substituted aspartate for glycine at position 310 of the alpha 1(II) chain of type II procollagen. The proband with hypochondrogenesis had a heterozygous single-base mutation that substituted serine for glycine at position 805. Type II collagen extracted from cartilage from the probands demonstrated the presence of type I collagen and a delayed electrophoretic mobility, indicating post-translational overmodifications. Analysis of CNBr peptides showed that, in proband 1, the entire peptides were overmodified. Examination of chondrocytes cultured in agarose or alginate indicated that there was a delayed secretion of type II procollagen. In addition, type II collagen synthesized by cartilage fragments from the probands demonstrated a decreased thermal stability. The melting temperature of the type II collagen containing the aspartate-for-glycine substitution was reduced by 4 degrees C, and that of the collagen containing the serine-for-glycine substitution was reduced by 2 degrees C. Electron microscopy of the extracellular matrix from the chondrocyte cultures showed a decreased density of matrix and the presence of unusually short and thin fibrils. Our results indicate that glycine substitutions in the N-terminal region of the type II collagen molecule can produce more severe phenotypes than mutations in the C-terminal region. The aspartate-for-glycine substitution at position 310, which was associated with defective secretion and a probable increased degradation of collagen, is the most destabilizing

  3. Substitution of aspartic acid for glycine at position 310 in type II collagen produces achondrogenesis II, and substitution of serine at position 805 produces hypochondrogenesis: analysis of genotype-phenotype relationships.

    PubMed Central

    Bonaventure, J; Cohen-Solal, L; Ritvaniemi, P; Van Maldergem, L; Kadhom, N; Delezoide, A L; Maroteaux, P; Prockop, D J; Ala-Kokko, L

    1995-01-01

    Two different mutations were found in two unrelated probands with lethal chondrodysplasias, one with achondrogenesis type II and the other with the less severe phenotype of hypochondrogenesis. The mutations in the COL2A1 gene were identified by denaturing gradient gel electrophoresis analysis of genomic DNA followed by dideoxynucleotide sequencing and restriction site analysis. The proband with achondrogenesis type II had a heterozygous single-base mutation that substituted aspartate for glycine at position 310 of the alpha 1(II) chain of type II procollagen. The proband with hypochondrogenesis had a heterozygous single-base mutation that substituted serine for glycine at position 805. Type II collagen extracted from cartilage from the probands demonstrated the presence of type I collagen and a delayed electrophoretic mobility, indicating post-translational overmodifications. Analysis of CNBr peptides showed that, in proband 1, the entire peptides were overmodified. Examination of chondrocytes cultured in agarose or alginate indicated that there was a delayed secretion of type II procollagen. In addition, type II collagen synthesized by cartilage fragments from the probands demonstrated a decreased thermal stability. The melting temperature of the type II collagen containing the aspartate-for-glycine substitution was reduced by 4 degrees C, and that of the collagen containing the serine-for-glycine substitution was reduced by 2 degrees C. Electron microscopy of the extracellular matrix from the chondrocyte cultures showed a decreased density of matrix and the presence of unusually short and thin fibrils. Our results indicate that glycine substitutions in the N-terminal region of the type II collagen molecule can produce more severe phenotypes than mutations in the C-terminal region. The aspartate-for-glycine substitution at position 310, which was associated with defective secretion and a probable increased degradation of collagen, is the most destabilizing

  4. Preliminary results of the analysis of CaII K spectroheliograms

    NASA Technical Reports Server (NTRS)

    Kariyappa, R.; Pap, Judit M.; Balasubramaniam, K. S.; Kuhn, Jeff R.

    1995-01-01

    The preliminary results of the photometry of CaII K spectroheliograms are presented. From the spectrograms for 1992, plages, the magnetic network, intranetwork elements and the chromospheric background were separated using the histogram method. The intensity and area of these separated features, as well as the full disk intensity, were derived. The spatial K index was compared to the spectral CaII K index derived from line profiles. It was found that the spatial K index and intensity of plages, the network elements and the intranetwork and background regions were highly correlated with the MgII h and k c/w ratio.

  5. Compatibility between shape equation and boundary conditions of lipid membranes with free edges.

    PubMed

    Tu, Z C

    2010-02-28

    Only some special open surfaces satisfying the shape equation of lipid membranes can be compatible with the boundary conditions. As a result of this compatibility, the first integral of the shape equation should vanish for axisymmetric lipid membranes, from which two theorems of nonexistence are verified: (i) there is no axisymmetric open membrane being a part of torus satisfying the shape equation; (ii) there is no axisymmetric open membrane being a part of a biconcave discodal surface satisfying the shape equation. Additionally, the shape equation is reduced to a second-order differential equation while the boundary conditions are reduced to two equations due to this compatibility. Numerical solutions to the reduced shape equation and boundary conditions agree well with the experimental data [A. Saitoh et al., Proc. Natl. Acad. Sci. U.S.A. 95, 1026 (1998)]. PMID:20192294

  6. Analysis of five forest harvesting simulation models. II. Paths, pitfalls, and other considerations

    SciTech Connect

    Goulet, D.V.; Iff, R.H.; Sirois, D.L.

    1980-01-01

    This is the second of two papers describing the conclusions from a study to determine the state of the art in timber harvesting computer simulation modeling. Five models were evaluated -- Forest Harvesting Simulation Model (FHSM), Full Tree Field Chipping (FTFC), Harvesting System Simulator (HSS), Simulation Applied to Logging Systems (SAPLOS), and Timber Harvesting and Transport Simulator (THATS) -- for their potential use in southern forest harvesting operations. In Part I, modeling characteristics and overall model philosophy were identified and illustrated. This included a detailed discussion of the wood flow process in each model, accounting strategies for productive/nonproductive times, performance variables used, and the different harvesting systems modelable. In Part II user implementation problems are discussed. Those dealt with in detail are the following: What questions can be asked of the model. What are the modeling tradeoffs, and how do they impact on the analysis. What are the computer skills necessary to work effectively with the model. What computer support is needed. Are the models operational. The results provide a good picture of the state of the art in timber harvesting computer simulation. Much learning has occurred in the generation of these models, and many modeling and implementation problems have been uncovered, some of which remain unsolved. Hence, the user needs to examine closely the model and the intended application so that results will represent useable, valid data. It is recommended that the development of timber harvesting computer simulation modeling continue so that existing and proposed timber harvesting strategies can be adequately evaluated. Design criteria are proposed. (Refs. 22).

  7. Genomic Analysis and Isolation of RNA Polymerase II Dependent Promoters from Spodoptera frugiperda

    PubMed Central

    Bleckmann, Maren; Fritz, Markus H.-Y.; Bhuju, Sabin; Jarek, Michael; Schürig, Margitta; Geffers, Robert; Benes, Vladimir; Besir, Hüseyin; van den Heuvel, Joop

    2015-01-01

    The Baculoviral Expression Vector System (BEVS) is the most commonly used method for high expression of recombinant protein in insect cells. Nevertheless, expression of some target proteins-especially those entering the secretory pathway- provides a severe challenge for the baculovirus infected insect cells, due to the reorganisation of intracellular compounds upon viral infection. Therefore, alternative strategies for recombinant protein production in insect cells like transient plasmid-based expression or stable expression cell lines are becoming more popular. However, the major bottleneck of these systems is the lack of strong endogenous polymerase II dependent promoters, as the strong baculoviral p10 and polH promoters used in BEVS are only functional in presence of the viral transcription machinery during the late phase of infection. In this work we present a draft genome and a transcriptome analysis of Sf21 cells for the identification of the first known endogenous Spodoptera frugiperda promoters. Therefore, putative promoter sequences were identified and selected because of high mRNA level or in analogy to other strong promoters in other eukaryotic organism. The chosen endogenous Sf21 promoters were compared to early viral promoters for their efficiency to trigger eGFP expression using transient plasmid based transfection in a BioLector Microfermentation system. Furthermore, promoter activity was not only shown in Sf21 cells but also in Hi5 cells. The novel endogenous Sf21 promoters were ranked according to their activity and expand the small pool of available promoters for stable insect cell line development and transient plasmid expression in insect cells. The best promoter was used to improve plasmid based transient transfection in insect cells substantially. PMID:26263512

  8. The Spear Horizon: First spatial analysis of the Schöningen site 13 II-4.

    PubMed

    Böhner, Utz; Serangeli, Jordi; Richter, Pascale

    2015-12-01

    The Spear Horizon (Schöningen 13 II-4) from Schöningen, Lower Saxony, Germany, is one of the most important archeological sites dating to the Middle Pleistocene. Until today, the numerous finds have only been published individually, often outside of their context. Here we present for the first time the distribution map of the Spear Horizon together with a spatial analysis of the different categories of remains (flint, bones, and woods). The finds are situated in a 10 m wide belt, which runs parallel to a former lakeshore. The distribution of faunal remains correlates closely with the distribution of flint artifacts and wooden objects. We have been able to distinguish five different sectors that can be aligned with different events or activities. The greatest density of finds was evident within an area of 11 × 15 m, where most of the horse skulls were recovered. Some of the square meters contain more than 150 finds. During the excavation the profiles were continually documented and these data help us to reconstruct the shoreline of the paleo-lake with considerable accuracy. Over a distance of 60 m, the thickness and density of the organic mud and peat layers could be reconstructed in high resolution. The distribution of finds shows no preferred orientation or selection through size. The analyses only indicate small-scale dislocations and limited taphonomic alterations. The fraction of lithic artifacts with size ranges less than 2 cm are preserved, while some smaller bone fragments are missing. Most of the wooden artifacts are in-situ, but were deformed by the ice load during the Saalian ice age. While some small charcoal remains as well as a burnt artifact have been observed, there is no evidence of burnt bones. Our results allow a first insight into the formation history of the site. PMID:26626956

  9. Purification, crystallization and preliminary X-ray diffraction analysis of the glyoxalase II from Leishmania infantum

    SciTech Connect

    Trincão, José; Sousa Silva, Marta; Barata, Lídia; Bonifácio, Cecília; Carvalho, Sandra; Tomás, Ana Maria; Ferreira, António E. N.; Cordeiro, Carlos; Ponces Freire, Ana; Romão, Maria João

    2006-08-01

    A glyoxalase II from L. infantum was cloned, purified and crystallized and its structure was solved by X-ray crystallography. In trypanosomatids, trypanothione replaces glutathione in all glutathione-dependent processes. Of the two enzymes involved in the glyoxalase pathway, glyoxalase I and glyoxalase II, the latter shows absolute specificity towards trypanothione thioester, making this enzyme an excellent model to understand the molecular basis of trypanothione binding. Cloned glyoxalase II from Leishmania infantum was overexpressed in Escherichia coli, purified and crystallized. Crystals belong to space group C222{sub 1} (unit-cell parameters a = 65.6, b = 88.3, c = 85.2 Å) and diffract beyond 2.15 Å using synchrotron radiation. The structure was solved by molecular replacement using the human glyoxalase II structure as a search model. These results, together with future detailed kinetic characterization using lactoyltrypanothione, should shed light on the evolutionary selection of trypanothione instead of glutathione by trypano-somatids.

  10. Analysis of Topaz-II thermionic fuel element performance using TFEHX

    SciTech Connect

    Klein, A.C. ); Pawlowski, R.A. )

    1993-01-20

    Data reported by Russian Scientists and engineers for the TOPAZ-II single cell thermionic fuel elments (TFE) is compared with analytical results calculated using the TFEHX computer program in order to benchmark the code. The results of this comparison show good agreement with the TOPAZ-II results over a wide range of power inputs, cesium vapor pressures, and other design variables. Future refinements of the TFEHX methodology should enhance the performance of the code to better predict single cell TFE behavior.

  11. The Mars Environmental Compatibility Assessment (MECA)

    NASA Technical Reports Server (NTRS)

    Meloy, Thomas P.; Marshall, John; Hecht, Michael

    1999-01-01

    The Mars Environmental Compatibility Assessment (MECA) will evaluate the Martian environment for soil and dust-related hazards to human exploration as part of the Mars Surveyor Program 2001 Lander. Sponsored by the Human Exploration and Development of Space (HEDS) enterprise, MECA's goal is to evaluate potential geochemical and environmental hazards that may confront future martian explorers, and to guide HEDS scientists in the development of high fidelity Mars soil simulants. In addition to objectives related to human exploration, the MECA data set will be rich in information relevant to basic geology, paleoclimate, and exobiology issues. The integrated MECA payload contains a wet-chemistry laboratory, a microscopy station, an electrometer to characterize the electrostatics of the soil and its environment, and arrays of material patches to study the abrasive and adhesive properties of soil grains. MECA is allocated a mass of 10 kg and a peak power usage of 15 W within an enclosure of 35 x 25 x 15 cm (figures I and 2). The Wet Chemistry Laboratory (WCL) consists of four identical cells that will accept samples from surface and subsurface regions accessible to the Lander's robotic arm, mix them with water, and perform extensive analysis of the solution. Using an array of ion-specific electrodes (ISEs), cyclic voltammetry, and electrochemical techniques, the chemistry cells will wet soil samples for measurement of basic soil properties of pH, redox potential, and conductivity. Total dissolved material, as well as targeted ions will be detected to the ppm level, including important exobiological ions such as Na, K+, Ca++, Mg++, NH4+, Cl, S04-, HC03, as well as more toxic ions such as Cu++, Pb++, Cd++, Hg++, and C104-. MECA's microscopy station combines optical and atomic-force microscopy (AFM) to image dust and soil particles from millimeters to nanometers in size. Illumination by red, green, and blue LEDs is augmented by an ultraviolet LED intended to excite

  12. SPITZER ANALYSIS OF H II REGION COMPLEXES IN THE MAGELLANIC CLOUDS: DETERMINING A SUITABLE MONOCHROMATIC OBSCURED STAR FORMATION INDICATOR

    SciTech Connect

    Lawton, B.; Gordon, K. D.; Meixner, M.; Sewilo, M.; Shiao, B.; Babler, B.; Bracker, S.; Meade, M.; Block, M.; Engelbracht, C. W.; Misselt, K.; Bolatto, A. D.; Carlson, L. R.; Hora, J. L.; Robitaille, T.; Indebetouw, R.; Madden, S. C.; Oliveira, J. M.; Vijh, U. P. E-mail: kgordon@stsci.ed

    2010-06-10

    H II regions are the birth places of stars, and as such they provide the best measure of current star formation rates (SFRs) in galaxies. The close proximity of the Magellanic Clouds allows us to probe the nature of these star forming regions at small spatial scales. To study the H II regions, we compute the bolometric infrared flux, or total infrared (TIR), by integrating the flux from 8 to 500 {mu}m. The TIR provides a measure of the obscured star formation because the UV photons from hot young stars are absorbed by dust and re-emitted across the mid-to-far-infrared (IR) spectrum. We aim to determine the monochromatic IR band that most accurately traces the TIR and produces an accurate obscured SFR over large spatial scales. We present the spatial analysis, via aperture/annulus photometry, of 16 Large Magellanic Cloud (LMC) and 16 Small Magellanic Cloud (SMC) H II region complexes using the Spitzer Space Telescope's IRAC (3.6, 4.5, 8 {mu}m) and MIPS (24, 70, 160 {mu}m) bands. Ultraviolet rocket data (1500 and 1900 A) and SHASSA H{alpha} data are also included. All data are convolved to the MIPS 160 {mu}m resolution (40 arcsec full width at half-maximum), and apertures have a minimum radius of 35''. The IRAC, MIPS, UV, and H{alpha} spatial analysis are compared with the spatial analysis of the TIR. We find that nearly all of the LMC and SMC H II region spectral energy distributions (SEDs) peak around 70 {mu}m at all radii, from {approx}10 to {approx}400 pc from the central ionizing sources. As a result, we find the following: the sizes of H II regions as probed by 70 {mu}m are approximately equal to the sizes as probed by TIR ({approx}70 pc in radius); the radial profile of the 70 {mu}m flux, normalized by TIR, is constant at all radii (70 {mu}m {approx} 0.45TIR); the 1{sigma} standard deviation of the 70 {mu}m fluxes, normalized by TIR, is a lower fraction of the mean (0.05-0.12 out to {approx}220 pc) than the normalized 8, 24, and 160 {mu}m normalized fluxes (0

  13. The Magnetic Heartbeat of the Sun; Diagnosing Pulses in the Solar MgII Index Using Wavelet Analysis

    NASA Astrophysics Data System (ADS)

    Rand, L.

    2015-12-01

    The solar Magnesium (Mg) II index, derived from the ratio of measurements across a solar absorption feature (280nm) in nearby spectral bands, serves as a proxy for solar chromospheric variability. Various space-borne instruments acquire MgII index data and, in comparison across instruments, the data appears to follow different temporal trends. These variations may lead to variations in the interpretation of model outputs used to understand and predict complex dynamics such as climate variability and space weather. This study seeks to reconcile the discrepancies between three MgII data sets in an attempt to create one, composite MgII index with elements common to all. For this investigation we use three temporally coincident data sets spanning 2003 to 2012: the SOlar Radiation and Climate Experiment (SORCE) SOLar STellar InterComparison Experiment (SOLSTICE), the National Oceanographic and Atmospheric Administration (NOAA) 16, and the University of Bremen Composite, compiled from various satellite records. Using wavelet analysis, we identify the statistically significant and independent signals of four known solar time scales in each of the data sets: the 24.7 day solar rotational period, the 12 day half-solar rotational period, the 3-7 month average lifetime of an active region, and the 11 year solar cycle. We then explore the time scales of variability remaining in the data records. We seek to define the remaining signal components as solar in origin, assumed common between sets, or as potentially originating from instrumental artifacts, not common to all sets. We find a signal with a 1-2 year period common to the three data records; a further comparison with the San Fernando Observatory (SFO) Calcium (Ca) II record establishes this period to be present in ground-based chromospheric variability measurement. In a last step, we use Bayesian analysis to quantify the uncertainty of a revised data set, comprised only of signals of known solar origin.

  14. High Pressure Hydrogen Materials Compatibility of Piezoelectric Films

    SciTech Connect

    Alvine, Kyle J.; Shutthanandan, V.; Bennett, Wendy D.; Bonham, Charles C.; Skorski, Daniel C.; Pitman, Stan G.; Dahl, Michael E.; Henager, Charles H.

    2010-12-02

    Abstract: Hydrogen is being considered as a next-generation clean burning fuel. However, hydrogen has well known materials issues, including blistering and embrittlement in metals. Piezoelectric materials are used as actuators in hydrogen fuel technology. We present studies of materials compatibility of piezoelectric films in a high pressure hydrogen environment. Absorption of high pressure hydrogen was studied with Elastic Recoil Detection Analysis (ERDA) and Rutherford Back Scattering (RBS) in lead zirconate titanate (PZT) and barium titanate (BTO) thin films. Hydrogen surface degradation in the form of blistering and Pb mixing was also observed.

  15. RFID in healthcare environment: electromagnetic compatibility regulatory issues.

    PubMed

    Censi, Federica; Calcagnini, Giovanni; Mattei, Eugenio; Triventi, Michele; Bartolini, Pietro

    2010-01-01

    Several wireless technology applications (RFID, WiFi, GSM, GPRS) have been developed to improve patient care, reaching a significant success and diffusion in healthcare. Given the potential development of such a technology, care must be paid on the potential risks deriving from the use of wireless device in healthcare, among which one of the most important is the electromagnetic interference with medical devices. The analysis of the regulatory issues concerning the electromagnetic compatibility of medical devices is essential to evaluate if and how the application of the current standards allows an effective control of the possible risks associated to the electromagnetic interference on medical devices. PMID:21096973

  16. Technical Analysis of the Hydrogen Energy Station Concept, Phase I and Phase II

    SciTech Connect

    TIAX, LLC

    2005-05-04

    patterns would be most viable for an energy station, TIAX developed several criteria for selecting a representative set of technology configurations. TIAX applied these criteria to all possible technology configurations to determine an optimized set for further analysis, as shown in Table ES-1. This analysis also considered potential energy station operational scenarios and their impact upon hydrogen and power production. For example, an energy station with a 50-kWe reformer could generate enough hydrogen to serve up to 12 vehicles/day (at 5 kg/fill) or generate up to 1,200 kWh/day, as shown in Figure ES-1. Buildings that would be well suited for an energy station would utilize both the thermal and electrical output of the station. Optimizing the generation and utilization of thermal energy, hydrogen, and electricity requires a detailed look at the energy transfer within the energy station and the transfer between the station and nearby facilities. TIAX selected the Baseline configuration given in Table ES-1 for an initial analysis of the energy and mass transfer expected from an operating energy station. Phase II The purpose of this technical analysis was to analyze the development of a hydrogen-dispensing infrastructure for transportation applications through the installation of a 50-75 kW stationary fuel cell-based energy station at federal building sites. The various scenarios, costs, designs and impacts of such a station were quantified for a hypothetical cost-shared program that utilizes a natural gas reformer to provide hydrogen fuel for both the stack(s) and a limited number of fuel cell powered vehicles, with the possibility of using cogeneration to support the building heat load.

  17. A radiographic, morphologic, biochemical and molecular analysis of a case of achondrogenesis type II resulting from substitution for a glycine residue (Gly691-->Arg) in the type II collagen trimer.

    PubMed

    Mortier, G R; Wilkin, D J; Wilcox, W R; Rimoin, D L; Lachman, R S; Eyre, D R; Cohn, D H

    1995-02-01

    The type II collagenopathies form a continuous spectrum of clinical severity, ranging from lethal achondrogenesis type II and hypochondrogenesis, through spondyloepiphyseal dysplasia, spondyloepimetaphyseal dysplasia and Kniest dysplasia to the Stickler syndrome and familial precocious osteoarthropathy at the mildest end of the spectrum. We have carried out a radiographic, morphologic, biochemical and molecular study in a case of achondrogenesis type II. Electron micrographs showed inclusion bodies of dilated rough endoplasmic reticulum in the chondrocytes and the presence of sparse collagen fibers in the cartilage matrix. Protein analysis of collagen from cartilage indicated posttranslational overmodification of the major cyanogen bromide peptides, and suggested a mutation near the carboxyl terminus of the type II collagen molecule. Analysis at the DNA level demonstrated that the phenotype was produced by a single base change (G-->C) that resulted in the substitution of glycine691 by arginine in the type II collagen triple helical domain. We confirm previous observations in three cases of hypochondrogenesis that glycine substitutions in the alpha 1(II) chain can result in a phenotype at the most severe end of the type II collagenopathy spectrum. PMID:7757081

  18. Automation of electromagnetic compatability (EMC) test facilities

    NASA Technical Reports Server (NTRS)

    Harrison, C. A.

    1986-01-01

    Efforts to automate electromagnetic compatibility (EMC) test facilities at Marshall Space Flight Center are discussed. The present facility is used to accomplish a battery of nine standard tests (with limited variations) deigned to certify EMC of Shuttle payload equipment. Prior to this project, some EMC tests were partially automated, but others were performed manually. Software was developed to integrate all testing by means of a desk-top computer-controller. Near real-time data reduction and onboard graphics capabilities permit immediate assessment of test results. Provisions for disk storage of test data permit computer production of the test engineer's certification report. Software flexibility permits variation in the tests procedure, the ability to examine more closely those frequency bands which indicate compatibility problems, and the capability to incorporate additional test procedures.

  19. Coating for components requiring hydrogen peroxide compatibility

    NASA Technical Reports Server (NTRS)

    Yousefiani, Ali (Inventor)

    2010-01-01

    The present invention provides a heretofore-unknown use for zirconium nitride as a hydrogen peroxide compatible protective coating that was discovered to be useful to protect components that catalyze the decomposition of hydrogen peroxide or corrode when exposed to hydrogen peroxide. A zirconium nitride coating of the invention may be applied to a variety of substrates (e.g., metals) using art-recognized techniques, such as plasma vapor deposition. The present invention further provides components and articles of manufacture having hydrogen peroxide compatibility, particularly components for use in aerospace and industrial manufacturing applications. The zirconium nitride barrier coating of the invention provides protection from corrosion by reaction with hydrogen peroxide, as well as prevention of hydrogen peroxide decomposition.

  20. Supernova 2014J at M82: II. Direct Analysis of A Middle-Class Type Ia Supernova

    NASA Astrophysics Data System (ADS)

    Vallely, Patrick; Moreno-Raya, M. E.; Baron, E.; Ruiz-Lapuente, Pilar; Domínguez, I.; Galbany, Lluís; González Hernández, J. I.; Méndez, J.; Hamuy, M.; López-Sánchez, A. R.; Catalán, S.; Cooke, E.; Fariña, C.; Génova-Santos, R.; Karjalainen, R.; Lietzen, H.; McCormac, J.; Riddick, F.; Rubiño-Martín, J. A.; Skillen, I.; Tudor, V.; Vaduvescu, O.

    2016-05-01

    We analyze a time series of optical spectra of SN 2014J from almost two weeks prior to maximum to nearly four months after maximum. We perform our analysis using the SYNOW code, which is well suited to track the distribution of the ions with velocity in the ejecta. We show that almost all of the spectral features during the entire epoch can be identified with permitted transitions of the common ions found in normal SNe Ia in agreement with previous studies. We show that 2014J is a relatively normal SN Ia. At early times the spectral features are dominated by Si II, S II, Mg II, and Ca II. These ions persist to maximum light with the appearance of Na I and Mg I. At later times iron-group elements also appear, as expected in the stratified abundance model of the formation of normal type Ia SNe. We do not find significant spectroscopic evidence for oxygen, until 100 days after maximum light. The +100 day identification of oxygen is tentative, and would imply significant mixing of unburned or only slight processed elements down to a velocity of 6,000 km~s-1. Our results are in relatively good agreement with other analyses in the IR. We briefly compare SN 2011fe to SN 2014J and conclude that the differences could be due to different central densities at ignition or differences in the C/O ratio of the progenitors.

  1. Analysis of TOPAZ II and SPACE-R space nuclear power plants using a modified thermionic model. Master's thesis

    SciTech Connect

    Habedank, O.D.

    1993-03-01

    Models based on the TDS thermionic diode model were developed for TOPAZ II and SPACER nuclear power systems. Several parameter studies were conducted with the TOPAZ II model. These determined system performance and efficiency while varying the following: (1) Coolant flow inlet temperatures. (2) Rate of coolant temperature change. (3) Power profile of the core. (4) Cesium reservoir temperature. Analysis of results indicate the model accurately represented the TOPAZ II system, underestimating published data by 10%. Coolant flow studies indicate that raising coolant temperatures up to 100 K higher increases system power by up to 5%. Additional increases in temperature result in gradual performance degradation. Varying the axial power profile of the core from the actual peaked profile to a flat profile results in a negligible 0.3% change in system performance. The peaked profile used in TOPAZ II produces the highest system efficiency of all the profiles modeled. The cesium pressure study indicates the system is operating above optimum cesium pressure and system performance is strongly dependent on cesium pressure. Increasing cesium reservoir temperature above design temperature by 30 K decreases system efficiency by 30%.

  2. Supernova 2014J at M82 - II. Direct analysis of a middle-class Type Ia supernova

    NASA Astrophysics Data System (ADS)

    Vallely, Patrick; Moreno-Raya, M. E.; Baron, E.; Ruiz-Lapuente, Pilar; Domínguez, I.; Galbany, Lluís; González Hernández, J. I.; Méndez, J.; Hamuy, M.; López-Sánchez, A. R.; Catalán, S.; Cooke, E.; Fariña, C.; Génova-Santos, R.; Karjalainen, R.; Lietzen, H.; McCormac, J.; Riddick, F.; Rubiño-Martín, J. A.; Skillen, I.; Tudor, V.; Vaduvescu, O.

    2016-08-01

    We analyse a time series of optical spectra of SN 2014J from almost two weeks prior to maximum to nearly four months after maximum. We perform our analysis using the SYNOW code, which is well suited to track the distribution of the ions with velocity in the ejecta. We show that almost all of the spectral features during the entire epoch can be identified with permitted transitions of the common ions found in normal supernovae (SNe) Ia in agreement with previous studies. We show that 2014J is a relatively normal SN Ia. At early times the spectral features are dominated by Si II, S II, Mg II, and Ca II. These ions persist to maximum light with the appearance of Na I and Mg I. At later times iron-group elements also appear, as expected in the stratified abundance model of the formation of normal Type Ia SNe. We do not find significant spectroscopic evidence for oxygen, until 100 d after maximum light. The +100 d identification of oxygen is tentative, and would imply significant mixing of unburned or only slight processed elements down to a velocity of 6000 kms-1. Our results are in relatively good agreement with other analyses in the infrared. We briefly compare SN 2011fe to SN 2014J and conclude that the differences could be due to different central densities at ignition or differences in the C/O ratio of the progenitors.

  3. Microwave spectrum compatibility in planetary research

    NASA Technical Reports Server (NTRS)

    Siegmeth, A. J.

    1976-01-01

    The paper presents an overview of solar system exploration, basic functions of the Deep Space Network (DSN), deep space microwave links, space research compatibility problems, and DSN's interference susceptibility. To maintain the operational integrity of competing radio systems using the microwave spectrum, the technology must extend to make possible the shared use of the spectral ranges without the ill effects of interferences. Suggestions are given which are only examples of many possible techniques that can eliminate or reduce interferences.

  4. Promiscuous activity of ER glucosidase II discovered through donor specificity analysis of UGGT

    SciTech Connect

    Miyagawa, Atsushi; Totani, Kiichiro; Matsuo, Ichiro; Ito, Yukishige

    2010-12-17

    Research highlights: {yields} UGGT has a narrow donor specificity. {yields} UGGT gave several non-natural high-mannose-type glycans. {yields} G-II has a promiscuous activity as broad specificity hexosidase. -- Abstract: In glycoprotein quality control system in the endoplasmic reticulum (ER), UGGT (UDP-glucose:glycoprotein glucosyltransferase) and glucosidase II (G-II) play key roles. UGGT serves as a glycoprotein folding sensor by virtue of its unique specificity to glucosylate glycoproteins at incompletely folded stage. By using various UDP-Glc analogues, we first analyzed donor specificity of UGGT, which was proven to be rather narrow. However, marginal activity was observed with UDP-galactose and UDP-glucuronic acid as well as with 3-, 4- and 6-deoxy glucose analogues to give corresponding transfer products. Intriguingly, G-II smoothly converted all of them back to Man{sub 9}GlcNAc{sub 2}, providing an indication that G-II has a promiscuous activity as a broad specificity hexosidase.

  5. Double Retort System for Materials Compatibility Testing

    SciTech Connect

    V. Munne; EV Carelli

    2006-02-23

    With Naval Reactors (NR) approval of the Naval Reactors Prime Contractor Team (NRPCT) recommendation to develop a gas cooled reactor directly coupled to a Brayton power conversion system as the Space Nuclear Power Plant (SNPP) for Project Prometheus (References a and b) there was a need to investigate compatibility between the various materials to be used throughout the SNPP. Of particular interest was the transport of interstitial impurities from the nickel-base superalloys, which were leading candidates for most of the piping and turbine components to the refractory metal alloys planned for use in the reactor core. This kind of contamination has the potential to affect the lifetime of the core materials. This letter provides technical information regarding the assembly and operation of a double retort materials compatibility testing system and initial experimental results. The use of a double retort system to test materials compatibility through the transfer of impurities from a source to a sink material is described here. The system has independent temperature control for both materials and is far less complex than closed loops. The system is described in detail and the results of three experiments are presented.

  6. Fully CMOS-compatible titanium nitride nanoantennas

    NASA Astrophysics Data System (ADS)

    Briggs, Justin A.; Naik, Gururaj V.; Petach, Trevor A.; Baum, Brian K.; Goldhaber-Gordon, David; Dionne, Jennifer A.

    2016-02-01

    CMOS-compatible fabrication of plasmonic materials and devices will accelerate the development of integrated nanophotonics for information processing applications. Using low-temperature plasma-enhanced atomic layer deposition (PEALD), we develop a recipe for fully CMOS-compatible titanium nitride (TiN) that is plasmonic in the visible and near infrared. Films are grown on silicon, silicon dioxide, and epitaxially on magnesium oxide substrates. By optimizing the plasma exposure per growth cycle during PEALD, carbon and oxygen contamination are reduced, lowering undesirable loss. We use electron beam lithography to pattern TiN nanopillars with varying diameters on silicon in large-area arrays. In the first reported single-particle measurements on plasmonic TiN, we demonstrate size-tunable darkfield scattering spectroscopy in the visible and near infrared regimes. The optical properties of this CMOS-compatible material, combined with its high melting temperature and mechanical durability, comprise a step towards fully CMOS-integrated nanophotonic information processing.

  7. An MR-compatible neonatal incubator

    PubMed Central

    Paley, M N J; Hart, A R; Lait, M; Griffiths, P D

    2012-01-01

    Objectives To develop a neonatal MR-compatible incubator for transporting babies between a neonatal intensive care unit and an MRI unit that is within the same hospital but geographically separate. Methods The system was strapped to a standard MR-compatible patient trolley, which provides space for resuscitation outside the incubator. A constant-temperature exothermic heat pad was used to maintain temperature together with a logging fluoro-optic temperature monitor and alarm system. The system has been designed to accommodate standard knee-sized coils from the major MR manufacturers. The original incubator was constructed from carbon fibre, but this required modification to prevent radiofrequency shading artefacts due to the conducting properties of the carbon fibre. A high-tensile polyester material was used, which combined light weight with high impact strength. The system could be moved onto the patient bed with the coils and infant in place by one technologist. Results Studies in eight neonatal patients produced high quality 1.5 T MR images with low motion artefacts. The incubator should also be compatible with imaging in 3 T MR systems, although further work is required to establish this. Images were acquired using both rapid and high-resolution sequences, including three-dimensional volumes, proton spectra and diffusion weighting. Conclusion The incubator provides a safe, quiet environment for neonates during transport and imaging, at low cost. PMID:22167517

  8. Career and Family – Are They Compatible?

    PubMed Central

    Hancke, K.; Toth, B.; Igl, W.; Ramsauer, B.; Bühren, A.; Wöckel, A.; Jundt, K.; Ditsch, N.; Gingelmaier, A.; Rhiem, K.; Vetter, K.; Friese, K.; Kreienberg, R.

    2012-01-01

    Purpose: Nowadays, most gynaecologists are female and the compatibility of job-related career and family life is an upcoming issue. The working group “Gender and Career” of the German Society for Gynaecology and Obstetrics (DGGG) designed a survey to reflect the present situation with a focus on the compatibility of career and family. Material and Methods: A web-based 74-item survey was filled out by members of the DGGG. In total, there were 1037 replies, 75 % female (n = 775) and 25 % male (n = 261) gynaecologists. Results: 62 % of the female and 80 % of the male respondents had already finished their doctoral theses and 2 % female and 13 % male had finished their PhD. Mean number of children was 1.06 (SD 1.08) in female and 1.68 (SD 1.34) in male gynaecologists. The majority of females desired day care for their children, but only 5 to 13 % of employers offer any day care. 88 % of the female and 72 % of the male physicians think that job-related career and family are not compatible. Conclusion: The majority of female gynaecologists wished to have professional child care, but most employers or other institutions do not offer this. This might be one of the reasons why career and family appear incompatible. PMID:25298544

  9. Oxygen Compatibility Testing of Composite Materials

    NASA Technical Reports Server (NTRS)

    Graf, Neil A.; Hudgins, Richard J.; McBain, Michael

    2000-01-01

    The development of polymer composite liquid oxygen LO2 tanks is a critical step in creating the next generation of launch vehicles. Future launch vehicles need to minimize the gross liftoff weight (GLOW), which is possible due to the 25%-40% reduction in weight that composite materials could provide over current aluminum technology. Although a composite LO2 tank makes these weight savings feasible, composite materials have not historically been viewed as "LO2 compatible." To be considered LO2 compatible, materials must be selected that will resist any type of detrimental, combustible reaction when exposed to usage environments. This is traditionally evaluated using a standard set of tests. However, materials that do not pass the standard tests can be shown to be safe for a particular application. This paper documents the approach and results of a joint NASA/Lockheed Martin program to select and verify LO2 compatible composite materials for liquid oxygen fuel tanks. The test approach developed included tests such as mechanical impact, particle impact, puncture, electrostatic discharge, friction, and pyrotechnic shock. These tests showed that composite liquid oxygen tanks are indeed feasible for future launch vehicles.

  10. Analysis of Critical Reactor Response for TOPAZ-II Water Immersion Scenarios

    NASA Astrophysics Data System (ADS)

    Ponomarev-Stepnoi, Nikolai N.; Glushkov, Yevgeny S.; Yermoshin, Mikhail Y.; Skorlygin, Vladimir V.

    1994-07-01

    The unmodified TOPAZ-II water immersion event leading to surrounding the reactor with water and filling with water all internal core cavities (including TFE NaK channels) may hypothetically result in criticality. This paper presents results of preliminary studies of such an accident. Possible scenarios have been analyzed as well as reactivity effects involving the water presence in internal core cavities. A preliminary coupled model has been developed to describe accident transients in the reactor and TFE. The model is based on assumptions that result in overestimating possible consequences. The numerical simulations results point at the TOPAZ-II reactor capability to quench effectively possible power bursts and predict stable periodic oscillations as a final system state, wherein steaming and then refilling up some internal core cavities occurs. That may be considered to be demonstration of the TOPAZ-II reactor self-control capability if its criticality involves water immersion event.

  11. The magnetic Bp star 36 Lyncis. II. A spectroscopic analysis of its co-rotating disk

    NASA Astrophysics Data System (ADS)

    Smith, M. A.; Wade, G. A.; Bohlender, D. A.; Bolton, C. T.

    2006-11-01

    We report on the physical properties of the disk-like structure of B8 IIIp star 36 Lyncis from line syntheses of phase-resolved, high resolution spectra obtained from the International Ultraviolet Explorer archives and from newly obtained ground-based spectra of the Hα absorption profile. This disk is highly inclined to the rotational axis and betrays its existence every half rotation cycle as one of two opposing sectors pass in front of the star. Although the disk absorption spectrum is at least ten times too weak to be visible in optical iron lines during these occultations, its properties can be readily examined in a large number of UV "iron curtain" lines because of their higher opacities. The UV Fe II and Fe III lines in particular permit a determination of the disk temperature: 7500±500 K and a column density of 3-1.5+3×1020 cm-2. The analysis of the variations of the UV resonance lines brings out some interesting details about the radiative properties of the disks: (1) they are optically thick in the C IV and Si IV doublets, (2) the range of excitation of the UV resonance lines is larger at the primary occultation (φ = 0.00) than at the secondary one, and (3) the relative strengths of the absorption peaks for the two occultations varies substantially from line to line. We have modeled the absorptions of the UV C IV resonance and Hα absorptions by means of a simulated disk with opaque and translucent components. Our simulations suggest that a gap separates the star and the inner edge of the disk. The disk extends radially out to ≥10 R*. The disk scale height perpendicular to the plane is ≈1 R*. However, the sector causing the primary occultation is about four times thicker than the opposite sector. The C IV scattering region extends to a larger height than the Hα region does, probably because it results from shock heating far from the cooler disk plane.

  12. Analysis of Learning of Contents Related to Astronomy in Elementary Education II

    NASA Astrophysics Data System (ADS)

    Voelzke, Marcos Rincon; de Moraes e Poffo, Roberta Izabella

    2012-11-01

    The Curriculum Proposal of the State of São Paulo presents in the discipline of Physical and Biological Sciences contents related to Earth and Universe, which are covered by the subject of Astronomy in the Elementary Education II (aged between 11 and 14). During the school year 2010, in a public school in Santo André, São Paulo, 89 pupils of the sixth year of an elementary school answered a questionnaire with ten open questions related to Astronomy to perform an analysis of the learning success of these concepts before and after the approach of the contents. With this work it is possible to compare the previous knowledge, mainly if there was an improvement in learning after imparting the concepts. In this way, it is possible to conclude what contents may be considered appropriate for this age and how to enhance the conveyance of astronomical contents in this step. With respect to learning the concepts by analysing the questionnaires, one can draw the following conclusions. In the first phase: The results generally indicate a lack of specific knowledge related to the subject Astronomy. Few pupils were able to say what a star is and had difficulties in citing constellations, and most could not identify the Milky Way. In the second phase: the results show a significant improvement in the pupils' performance in general. All groups showed a good level in conceptualizing and associating the discussed topics. It could be observed that it still proved as a difficulty for most of the pupils to conceptualize a star, to explain what it is, but on the other hand, one of the issues with greater correctness was precisely the one with respect to the sun. They do not exactly define a star but know that the Sun is one, and that is really good because there was an association. With respect to learning, it is concluded that it was significant and efficient, considering that most learners progressed better at the end of the school year with respect to the concepts.

  13. Sorafenib in advanced melanoma: a Phase II randomised discontinuation trial analysis.

    PubMed

    Eisen, T; Ahmad, T; Flaherty, K T; Gore, M; Kaye, S; Marais, R; Gibbens, I; Hackett, S; James, M; Schuchter, L M; Nathanson, K L; Xia, C; Simantov, R; Schwartz, B; Poulin-Costello, M; O'Dwyer, P J; Ratain, M J

    2006-09-01

    The effects of sorafenib--an oral multikinase inhibitor targeting the tumour and tumour vasculature--were evaluated in patients with advanced melanoma enrolled in a large multidisease Phase II randomised discontinuation trial (RDT). Enrolled patients received a 12-week run-in of sorafenib 400 mg twice daily (b.i.d.). Patients with changes in bi-dimensional tumour measurements <25% from baseline were then randomised to sorafenib or placebo for a further 12 weeks (ie to week 24). Patients with > or =25% tumour shrinkage after the run-in continued on open-label sorafenib, whereas those with > or =25% tumour growth discontinued treatment. This analysis focussed on secondary RDT end points: changes in bi-dimensional tumour measurements from baseline after 12 weeks and overall tumour responses (WHO criteria) at week 24, progression-free survival (PFS), safety and biomarkers (BRAF, KRAS and NRAS mutational status). Of 37 melanoma patients treated during the run-in phase, 34 were evaluable for response: one had > or =25% tumour shrinkage and remained on open-label sorafenib; six (16%) had <25% tumour growth and were randomised (placebo, n=3; sorafenib, n=3); and 27 had > or =25% tumour growth and discontinued. All three randomised sorafenib patients progressed by week 24; one remained on sorafenib for symptomatic relief. All three placebo patients progressed by week-24 and were re-started on sorafenib; one experienced disease re-stabilisation. Overall, the confirmed best responses for each of the 37 melanoma patients who received sorafenib were 19% stable disease (SD) (ie n=1 open-label; n=6 randomised), 62% (n=23) progressive disease (PD) and 19% (n=7) unevaluable. The overall median PFS was 11 weeks. The six randomised patients with SD had overall PFS values ranging from 16 to 34 weeks. The most common drug-related adverse events were dermatological (eg rash/desquamation, 51%; hand-foot skin reaction, 35%). There was no relationship between V600E BRAF status and disease

  14. Emissive or nonemissive? A theoretical analysis of the phosphorescence efficiencies of cyclometalated platinum(II) complexes.

    PubMed

    Tong, Glenna So-Ming; Che, Chi-Ming

    2009-07-20

    We herein report a theoretical analysis based on a density functional theory/time-dependent density functional theory (DFT/TDDFT) approach to understand the different phosphorescence efficiencies of a family of cyclometalated platinum(II) complexes: [Pt(NCN)Cl] (1; NCN = 1,3-bis(2-pyridyl)phenyl(-)), [Pt(CNN)Cl] (2; CNN = 6-phenyl-2,2'-bipyridyl(-)), [Pt(CNC)(CNPh)] (3; CNC = 2,6-diphenylpyridyl(2-)), [Pt(R-CNN)Cl] (4; R-CNN = 3-(6'-(2''-naphthyl)-2'-pyridyl)isoquinolinyl(-)), and [Pt(R-CNC)(CNPh)] (5; R-CNC = 2,6-bis(2'-naphthyl)pyridyl(2-)). By considering both the spin-orbit coupling (SOC) and the electronic structures of these complexes at their respective optimized singlet ground (S(0)) and first triplet (T(opt)(1)) excited states, we were able to rationalize the experimental findings that 1) 1 is a strong emitter while its isomer 2 is only weakly emissive in CH(2)Cl(2) solution at room temperature; 2) although the cyclometalated ligand of 3 has a higher ligand-field strength than that of 1, 3 is nonemissive in CH(2)Cl(2) solution at 298 K; and 3) extension of pi conjugation at the lateral aryl rings of the cyclometalated ligands of 2 and 3 to give 4 and 5, respectively, leads to increased emission quantum yields under the same conditions. We found that Jahn-Teller and pseudo-Jahn-Teller effects are operative in complexes 2 and 3, respectively, on going from the optimized S(0) ground state to the optimized T(opt)(1) excited state, and thus lead to large excited-state structural distortions and hence fast nonradiative decay. Furthermore, a strong-field ligand may push the two different occupied d orbitals so far apart that the SOC effect is small and the radiative decay rate is slow. This work is an example of electronic-structure-driven tuning of the phosphorescence efficiency, and the DFT/TDDFT approach is demonstrated to be a versatile tool for the design of phosphorescent materials with target characteristics. PMID:19544517

  15. Column dynamic studies and breakthrough curve analysis for Cd(II) and Cu(II) ions adsorption onto palm oil boiler mill fly ash (POFA).

    PubMed

    Aziz, Abdul Shukor Abdul; Manaf, Latifah Abd; Man, Hasfalina Che; Kumar, Nadavala Siva

    2014-01-01

    This paper investigates the adsorption characteristics of palm oil boiler mill fly ash (POFA) derived from an agricultural waste material in removing Cd(II) and Cu(II) from aqueous solution via column studies. The performance of the study is described through the breakthrough curves concept under relevant operating conditions such as column bed depths (1, 1.5, and 2 cm) and influent metal concentrations (5, 10, and 20 mg/L). The Cd(II) and Cu(II) uptake mechanism is particularly bed depth- and concentration-dependant, favoring higher bed depth and lower influent metal concentration. The highest bed capacity of 34.91 mg Cd(II)/g and 21.93 mg Cu(II)/g of POFA was achieved at 20 mg/L of influent metal concentrations, column bed depth of 2 cm, and flow rate of 5 mL/min. The whole breakthrough curve simulation for both metal ions were best described using the Thomas and Yoon–Nelson models, but it is apparent that the initial region of the breakthrough for Cd(II) was better described using the BDST model. The results illustrate that POFA could be utilized effectively for the removal of Cd(II) and Cu(II) ions from aqueous solution in a fixed-bed column system. PMID:24659435

  16. Type II Toxoplasma gondii KU80 knockout strains enable functional analysis of genes required for cyst development and latent infection.

    PubMed

    Fox, Barbara A; Falla, Alejandra; Rommereim, Leah M; Tomita, Tadakimi; Gigley, Jason P; Mercier, Corinne; Cesbron-Delauw, Marie-France; Weiss, Louis M; Bzik, David J

    2011-09-01

    Type II Toxoplasma gondii KU80 knockouts (Δku80) deficient in nonhomologous end joining were developed to delete the dominant pathway mediating random integration of targeting episomes. Gene targeting frequency in the type II Δku80 Δhxgprt strain measured at the orotate (OPRT) and the uracil (UPRT) phosphoribosyltransferase loci was highly efficient. To assess the potential of the type II Δku80 Δhxgprt strain to examine gene function affecting cyst biology and latent stages of infection, we targeted the deletion of four parasite antigen genes (GRA4, GRA6, ROP7, and tgd057) that encode characterized CD8(+) T cell epitopes that elicit corresponding antigen-specific CD8(+) T cell populations associated with control of infection. Cyst development in these type II mutant strains was not found to be strictly dependent on antigen-specific CD8(+) T cell host responses. In contrast, a significant biological role was revealed for the dense granule proteins GRA4 and GRA6 in cyst development since brain tissue cyst burdens were drastically reduced specifically in mutant strains with GRA4 and/or GRA6 deleted. Complementation of the Δgra4 and Δgra6 mutant strains using a functional allele of the deleted GRA coding region placed under the control of the endogenous UPRT locus was found to significantly restore brain cyst burdens. These results reveal that GRA proteins play a functional role in establishing cyst burdens and latent infection. Collectively, our results suggest that a type II Δku80 Δhxgprt genetic background enables a higher-throughput functional analysis of the parasite genome to reveal fundamental aspects of parasite biology controlling virulence, pathogenesis, and transmission. PMID:21531875

  17. Stereoselective analysis of D and L dansyl amino acids as the mixed chelate copper(II) complexes by HPLC.

    PubMed

    Lam, S

    1984-09-01

    This paper reviews the mixed chelation approach to resolution of the optical isomers of D and L dansyl amino acids by high performance liquid chromatography. The use of eluants containing Cu(II) complexes of L-proline, L-arginine, L-histidine, and L-histidine methyl ester effected the separation of many D and L amino acids, including those with aliphatic, polar, and aromatic substituents. The mechanism of separation, which is based on the preferential ternary complex formation of the analyte amino acid and the chiral chelate with Cu(II) in the mobile phase, is discussed. The stereoselectivity depends mainly on the different steric interactions between the alkyl side chains of the amino acid analytes and the chiral ligands coordinating around Cu(II), although such parameters as pH, temperature, organic modifier, and concentration of the chiral additive also affect the chromatographic separation. Among the chiral ligands studied, L-histidine methyl ester is unique in that it possesses both achiral selectivity for the dansyl amino acids and chiral selectivity for the respective D and L enantiomers. With a mobile phase gradient of acetonitrile in a buffer containing Cu(II) L-histidine methyl ester complex, a stereoselective procedure was devised for the analysis of D and L amino acid enantiomers, achieving the separation that the current amino acid analyzer could not perform. Finally, the use of the mixed chelation approach in two biomedical studies is described. In the first application, the histidine methyl ester gradient was adapted for analyzing amino acids in cerebrospinal fluid; in the second, an L-aspartame Cu(II) complex eluant was developed for measuring the urine concentration of D and L pipecolic acid (piperidine-2-carboxylic acid), a metabolite of lysine. PMID:6490790

  18. Selective solid-phase extraction and analysis of trace-level Cr(III), Fe(III), Pb(II), and Mn(II) Ions in wastewater using diethylenetriamine-functionalized carbon nanotubes dispersed in graphene oxide colloids.

    PubMed

    Zhu, Xiangbing; Cui, Yuemei; Chang, Xijun; Wang, Hua

    2016-01-01

    Multi-walled carbon nanotubes (MCNTs) were dispersed in graphene oxide (GO) colloids to be further functionalized with diethylenetriamine (DETA), resulting in GO-MCNTs-DETA nanocomposites for the solid-phase extraction and analysis of Cr(III), Fe(III), Pb(II), and Mn(II) ions at the trace levels in wastewater. Inductively coupled plasma optical emission spectrometry (ICP-OES) indicates that this new solid-phase sorbent could facilitate the maximum static adsorption capacities of 5.4, 13.8, 6.6 and 9.5 mg g(-1) for Cr(III), Fe(III), Pb(II), and Mn(II) ions, respectively, showing the adsorption capacity up to 95% within about 30 min. Moreover, the detection limits of the GO-MCNTs-DETA-based analysis method were found to be 0.16, 0.50, 0.24 and 0.38 ng mL(-1) for Cr(III), Fe(III), Pb(II), and Mn(II) ions, respectively, with the relative standard deviation of lower than 3.0% (n=5). Importantly, common coexisting ions showed no significant interference on the separation and pre-concentration of these heavy metal ions at pH 4.0. Subsequently, the GO-MCNTs-DETA sorbent was successfully employed for the separation and analysis of trace-level Cr(III), Fe(III), Pb(II), and Mn(II) ions in wastewater samples yielding 75-folds concentration factors. PMID:26695275

  19. The Multiple Resonance Probe: A Novel Device for Industry Compatible Plasma Diagnostics

    NASA Astrophysics Data System (ADS)

    Brinkmann, Ralf Peter; Storch, Robert; Lapke, Martin; Oberrath, Jens; Schulz, Christian; Styrnoll, Tim; Zietz, Christian; Awakowicz, Peter; Musch, Thomas; Mussenbrock, Thomas; Rolfes, Ilona

    2012-10-01

    To be useful for the supervision or control of technical plasmas, a diagnostic method must be i) robust and stable, ii) insensitive to perturbation by the process, iii) itself not perturbing the process, iv) clearly and easily interpretable without the need for calibration, v) compliant with the requirements of process integration, and, last but not least, vi) economical in terms of investment, footprint, and maintenance. Plasma resonance spectroscopy, exploiting the natural ability of plasmas to resonate on or near the electron plasma frequency, provides a good basis for such an ``industry compatible'' plasma diagnostics. The contribution will describe the general idea of active plasma resonance spectroscopy and introduce a mathematical formalism for its analysis. It will then focus on the novel multipole resonance probe (MRP), where the excited resonances can be classified explicitly and the connection between the probe response and the desired electron density can be cast as a simple formula. The current state of the MRP project will be described, including the experimental characterization of a prototype in comparison with Langmuir probes, and the development of a specialized measurement circuit.

  20. Assessing shelf aggregate environmental compatibility and suitability for beach nourishment: a case study for Tuscany (Italy).

    PubMed

    Bigongiari, Nicola; Cipriani, Luigi E; Pranzini, Enzo; Renzi, Monia; Vitale, Giovanni

    2015-04-15

    Beach nourishment practices are a key aspect in coastal management plans for stakeholders and communities. Stemming from a concrete case-study (Tuscany), this research analyzes: (i) principal problems of current law regulating dredging, (ii) gaps in technical guidelines, (iii) advantages of integrated approaches to the decision-making process, (iv) possible applicable nourishment options and their costs and benefits. Our results show that sand compatibility is driven mainly by grain-size stability due to the occurrence of lower pollution levels in off-shore deposits than in threatened beaches, thus current laws and guidelines should be improved to fill the evident gap in the evaluation process and to include a more complete approach to data evaluation and an integrated approach to ecotoxicity evaluation, which is relevant in cases of geochemical anomalies. The cost-benefit analysis performed indicates that only dredging intended to manage more than 1 million m(3) of aggregates would represent a real advantage for local communities. PMID:25684591

  1. Stability and compatibility studies with the inorganic explosive 2-(5-cyanotetrazolato)pentaamminecobalt(III) perchlorate (CP)

    SciTech Connect

    Massis, T.M.; Morenus, P.K.; Huskisson, D.H.; Merrill, R.M.

    1980-01-01

    2-(5-Cyanotetrazolato)pentaamminecobalt(III) perchlorate (CP) is an inorganic secondary explosive that has been developed for applications involving deflagration-to-detonation transition. Previously the primary explosives lead azide and lead styphnate had been used. Stability and compatibility studies with CP have been conducted for periods up to three years. By using the rate of formation of cobalt(II) as the prime stability measurement for CP no reaction above baseline has been observed at temperatures at or below 80/sup 0/C. At 120/sup 0/C, approximately 2.2% reaction has been measured after three years with the concentration approaching a constant value. With the typical materials of construction in low voltage detonators, no compatibility problems with CP have been found. Adhesives such as epoxies have also shown good compatibility characteristics with CP. The only material tested thus far that exhibits potential compatibility problems with CP has been copper.

  2. Implementation of Revision 19 of the TRUPACT-II Safety Analysis Report at Rocky Flats Environmental Technology Site

    SciTech Connect

    D'Amico, E.; O'Leary, J.; Bell, S.; Djordjevic, S.; Givens, C,; Shokes, T.; Thompson, S.; Stahl, S.

    2003-02-25

    The U.S. Nuclear Regulatory Commission on July 27, 2001 approved Revision 19 of the TRUPACT-II Safety Analysis Report (SAR) and the associated TRUPACT-II Authorized Methods for Payload Control (TRAMPAC). Key initiatives in Revision 19 included matrix depletion, unlimited mixing of shipping categories, a flammability assessment methodology, and an alternative methodology for the determination of flammable gas generation rates. All U.S. Department of Energy (DOE) sites shipping transuranic (TRU) waste to the Waste Isolation Pilot Plant (WIPP) were required to implement Revision 19 methodology into their characterization and waste transportation programs by May 20, 2002. An implementation process was demonstrated by the Rocky Flats Environmental Technology Site (RFETS) in Golden, Colorado. The three-part process used by RFETS included revision of the site-specific TRAMPAC, an evaluation of the contact-handled TRU waste inventory against the regulations in Revision 19, and design and development of software to facilitate future inventory analyses.

  3. Analysis of serum from type II diabetes mellitus and diabetic complication using surface-enhanced Raman spectra (SERS)

    NASA Astrophysics Data System (ADS)

    Han, H. W.; Yan, X. L.; Dong, R. X.; Ban, G.; Li, K.

    2009-03-01

    In this paper, we show surface-enhanced Raman spectra (SERS) of serums from type II diabetes mellitus and diabetic complication (coronary disease, glaucoma and cerebral infarction), and analyze the SERS through the multivariate statistical methods of principal component analysis (PCA). In particular, we find that there exist many adenines in these serums, which maybe come from DNA (RNA) damage. The relative intensity of the band at 725±2 cm-1 assigned to adenine is higher for patients than for the healthy volunteers; therefore, it can be used as an important ‘fingerprint’ in order to diagnose these diseases. It is also shown that serums from type II diabetes mellitus group, diabetic complication group and healthy volunteers group can be discriminated by PCA.

  4. Mercury bioaccumulation and bioaccumulation factors for Everglades mosquitofish as related to sulfate: a re-analysis of Julian II (2013).

    PubMed

    Pollman, Curtis D; Axelrad, Donald M

    2014-11-01

    The Everglades, an ecosystem of international significance, has elevated biota mercury levels representing risk to human and wildlife consumers of fish. Given the critical role of sulfate in the methylation of mercury, and because there is a significant agricultural contribution, one potential means of reducing these mercury levels is reducing Everglades sulfate inputs. Julian II (Bull Environ Contam Toxicol 90:329-332, 2013) conducted regression modeling of the relationship between surface water sulfate concentrations and Gambusia spp. mercury bioconcentration factors across the major hydrologic subunits of the Everglades, and used those results to draw conclusions about the role of sulfate in the cycling of mercury in the Everglades. We however demonstrate a number of fundamental problems with the analysis, interpretation and conclusions. As a result, we strongly caution against using the results of Julian II (Bull Environ Contam Toxicol 90:329-332, 2013) to formulate management decisions regarding mitigation of the Everglades mercury problem. PMID:25260994

  5. High-resolution analysis of the murine MHC class II immunopeptidome.

    PubMed

    Sofron, Adriana; Ritz, Danilo; Neri, Dario; Fugmann, Tim

    2016-02-01

    The reliable identification of peptides bound to major histocompatibility complex (MHC) class II is fundamental for the study of the host immune response against pathogens and the pathogenesis of autoimmune conditions. Here, we describe an improved methodology combining immuno-affinity enrichment of MHC class II complexes, optimized elution conditions and quadrupole Orbitrap mass spectrometry-based characterization of the immunopeptidome. The methodology allowed the identification of over 1000 peptides with 1% false discovery rate from 10(8) murine A20 lymphoma cells. The study revealed the I-A(d) -specific motif in high resolution after multisequence alignment. The methodology was generally applied to the purification of MHC class II from cell lines and murine spleens. We identified 2963 peptides from BALB/c and 2712 from C57BL/6 mouse spleens. The identification of peptides bound to MHC class II in vitro and in vivo will facilitate the characterization of T-cell specificities, as well as the development of biotherapeutics and vaccines. PMID:26495903

  6. Mutation analysis of type II Gaucher disease in five Taiwanese children: identification of two novel mutations.

    PubMed

    Tsai, F J; Lee, C C; Wu, M C; Lin, S P; Lin, C Y; Tsai, C H; Kodama, H; Wu, J Y

    2001-01-01

    Gaucher disease (GD), one of the most prevalent lysosomal storage diseases, is caused by deficiency of lysosomal acid beta-glucosidase (GBA). It is divided into three types according to the presence and progression of neurologic symptoms. Of those, type II is relatively rare and most severe; patients usually die before the age of two years. Using polymerase chain reaction (PCR) and direct sequencing of GBA gene in five Taiwanese type II GD patients, we identified two novel mutations: G355D and three-nucleotide insertion in exon 7 of GBA. The latter resulted in an in-frame insertion of a methionine residue between Leu241 and Ser242. L444P, the second most common GD allele among non-Jewish Caucasian population, was found in all five type II GD patients (50%). Overall, 9 out of 10 GD alleles were identified in this study. Direct sequencing of all PCR products led to high detection rate of GD alleles and identification of the RecNci 1 alleles. In the future, high throughput sequencing will make it possible identifying more rare mutations in type II GD patients. PMID:11550412

  7. Winning the War: A Historical Analysis of the FFA during World War II

    ERIC Educational Resources Information Center

    Wolf, Kattlyn J.; Connors, James J.

    2009-01-01

    The United States' participation in World War II affected millions of men, women, and children, both at home and around the world. The war effort also affected the Future Farmers of America (FFA). FFA members, agriculture teachers, and national FFA officers all volunteered to serve their country during the war. Local FFA chapters and individual…

  8. THREE-DIMENSIONAL GEOMETRIES AND THE ANALYSIS OF H II REGIONS

    SciTech Connect

    Wood, Kenneth; Barnes, J. E.; Ercolano, Barbara; Haffner, L. M.; Reynolds, R. J.; Dale, J.

    2013-06-20

    We compare emission line intensities from photoionization models of smooth and fractal shell geometries for low density H II regions, with particular focus on the low-ionization diagnostic diagram [N II]/H{alpha} versus H{alpha}. Building on previously published models and observations of Barnard's Loop, we show that the observed range of intensities and variations in the line intensity ratios may be reproduced with a three-dimensional shell geometry. Our models adopt solar abundances throughout the model nebula, in contrast with previous one-dimensional modeling which suggested the variations in line intensity ratios could only be reproduced if the heavy element abundances were increased by a factor of {approx}1.4. For spatially resolved H II regions, the multiple sightlines that pierce and sample different ionization and temperature conditions within smooth and fractal shells produce a range of line intensities that are easily overlooked if only the total integrated intensities from the entire nebula model are computed. Our conclusion is that inference of H II region properties, such as elemental abundances, via photoionization models of one-dimensional geometries must be treated with caution and further tested through three-dimensional modeling.

  9. Development of hazard-compatible building fragility and vulnerability models

    USGS Publications Warehouse

    Karaca, E.; Luco, N.

    2008-01-01

    We present a methodology for transforming the structural and non-structural fragility functions in HAZUS into a format that is compatible with conventional seismic hazard analysis information. The methodology makes use of the building capacity (or pushover) curves and related building parameters provided in HAZUS. Instead of the capacity spectrum method applied in HAZUS, building response is estimated by inelastic response history analysis of corresponding single-degree-of-freedom systems under a large number of earthquake records. Statistics of the building response are used with the damage state definitions from HAZUS to derive fragility models conditioned on spectral acceleration values. Using the developed fragility models for structural and nonstructural building components, with corresponding damage state loss ratios from HAZUS, we also derive building vulnerability models relating spectral acceleration to repair costs. Whereas in HAZUS the structural and nonstructural damage states are treated as if they are independent, our vulnerability models are derived assuming "complete" nonstructural damage whenever the structural damage state is complete. We show the effects of considering this dependence on the final vulnerability models. The use of spectral acceleration (at selected vibration periods) as the ground motion intensity parameter, coupled with the careful treatment of uncertainty, makes the new fragility and vulnerability models compatible with conventional seismic hazard curves and hence useful for extensions to probabilistic damage and loss assessment.

  10. An Evaluation of Blood Compatibility of Silver Nanoparticles.

    PubMed

    Huang, He; Lai, Wenjia; Cui, Menghua; Liang, Ling; Lin, Yuchen; Fang, Qiaojun; Liu, Ying; Xie, Liming

    2016-01-01

    Silver nanoparticles (AgNPs) have tremendous potentials in medical devices due to their excellent antimicrobial properties. Blood compatibility should be investigated for AgNPs due to the potential blood contact. However, so far, most studies are not systematic and have not provided insights into the mechanisms for blood compatibility of AgNPs. In this study, we have investigated the blood biological effects, including hemolysis, lymphocyte proliferation, platelet aggregation, coagulation and complement activation, of 20 nm AgNPs with two different surface coatings (polyvinyl pyrrolidone and citrate). Our results have revealed AgNPs could elicit hemolysis and severely impact the proliferation and viability of lymphocytes at all investigated concentrations (10, 20, 40 μg/mL). Nevertheless, AgNPs didn't show any effect on platelet aggregation, coagulation process, or complement activation at up to ~40 μg/mL. Proteomic analysis on AgNPs plasma proteins corona has revealed that acidic and small molecular weight blood plasma proteins were preferentially adsorbed onto AgNPs, and these include some important proteins relevant to hemostasis, coagulation, platelet, complement activation and immune responses. The predicted biological effects of AgNPs by proteomic analysis are mostly consistent with our experimental data since there were few C3 components on AgNPs and more negative than positive factors involving platelet aggregation and thrombosis. PMID:27145858

  11. An Evaluation of Blood Compatibility of Silver Nanoparticles

    PubMed Central

    Huang, He; Lai, Wenjia; Cui, Menghua; Liang, Ling; Lin, Yuchen; Fang, Qiaojun; Liu, Ying; Xie, Liming

    2016-01-01

    Silver nanoparticles (AgNPs) have tremendous potentials in medical devices due to their excellent antimicrobial properties. Blood compatibility should be investigated for AgNPs due to the potential blood contact. However, so far, most studies are not systematic and have not provided insights into the mechanisms for blood compatibility of AgNPs. In this study, we have investigated the blood biological effects, including hemolysis, lymphocyte proliferation, platelet aggregation, coagulation and complement activation, of 20 nm AgNPs with two different surface coatings (polyvinyl pyrrolidone and citrate). Our results have revealed AgNPs could elicit hemolysis and severely impact the proliferation and viability of lymphocytes at all investigated concentrations (10, 20, 40 μg/mL). Nevertheless, AgNPs didn’t show any effect on platelet aggregation, coagulation process, or complement activation at up to ~40 μg/mL. Proteomic analysis on AgNPs plasma proteins corona has revealed that acidic and small molecular weight blood plasma proteins were preferentially adsorbed onto AgNPs, and these include some important proteins relevant to hemostasis, coagulation, platelet, complement activation and immune responses. The predicted biological effects of AgNPs by proteomic analysis are mostly consistent with our experimental data since there were few C3 components on AgNPs and more negative than positive factors involving platelet aggregation and thrombosis. PMID:27145858

  12. Analysis of type II diabetes mellitus adipose-derived stem cells for tissue engineering applications.

    PubMed

    Minteer, Danielle Marie; Young, Matthew T; Lin, Yen-Chih; Over, Patrick J; Rubin, J Peter; Gerlach, Jorg C; Marra, Kacey G

    2015-01-01

    To address the functionality of diabetic adipose-derived stem cells in tissue engineering applications, adipose-derived stem cells isolated from patients with and without type II diabetes mellitus were cultured in bioreactor culture systems. The adipose-derived stem cells were differentiated into adipocytes and maintained as functional adipocytes. The bioreactor system utilizes a hollow fiber-based technology for three-dimensional perfusion of tissues in vitro, creating a model in which long-term culture of adipocytes is feasible, and providing a potential tool useful for drug discovery. Daily metabolic activity of the adipose-derived stem cells was analyzed within the medium recirculating throughout the bioreactor system. At experiment termination, tissues were extracted from bioreactors for immunohistological analyses in addition to gene and protein expression. Type II diabetic adipose-derived stem cells did not exhibit significantly different glucose consumption compared to adipose-derived stem cells from patients without type II diabetes (p > 0.05, N = 3). Expression of mature adipocyte genes was not significantly different between diabetic/non-diabetic groups (p > 0.05, N = 3). Protein expression of adipose tissue grown within all bioreactors was verified by Western blotting.The results from this small-scale study reveal adipose-derived stem cells from patients with type II diabetes when removed from diabetic environments behave metabolically similar to the same cells of non-diabetic patients when cultured in a three-dimensional perfusion bioreactor, suggesting that glucose transport across the adipocyte cell membrane, the hindrance of which being characteristic of type II diabetes, is dependent on environment. The presented observation describes a tissue-engineered tool for long-term cell culture and, following future adjustments to the culture environment and increased sample sizes, potentially for anti-diabetic drug testing. PMID:26090087

  13. A revised structure and hydrogen bonding system in cellulose II from a neutron fiber diffraction analysis

    SciTech Connect

    Langan, P.; Nishiyama, Y.; Chanzy, H.

    1999-11-03

    The crystal and molecular structure and hydrogen bonding system in cellulose II have been revised using new neutron diffraction data extending to 1.2 {angstrom} resolution collected from two highly crystalline fiber samples of mercerized flax. Mercerization was achieved in NaOH/H{sub 2}O for one sample and in NaOD/D{sub 2}O for the other, corresponding to the labile hydroxymethyl moieties being hydrogenated and deuterated, respectively. Fourier difference maps were calculated in which neutron difference amplitudes were combined with phases calculated from two revised X-ray models of cellulose II. The revised phasing models were determined by refinement against the X-ray data set of Kolpak and Blackwell, using the LALS methodology. Both models have two antiparallel chains organized in a P2{sub 1} space group and unit cell parameters: a = 8.01 {angstrom}, b = 9.04 {angstrom}, c = 10.36 {angstrom}, and {gamma} = 117.1{degree}. One has equivalent backbone conformations for both chains but different conformations for the hydroxymethyl moieties: gt for the origin chain and tg for the center chain. The second model based on the recent crystal structures of cellotetraose, has different conformations for the two chains but nearly equivalent conformations for the hydroxymethyl moieties. On the basis of the X-ray data alone, the models could not be differentiated. From the neutron Fourier difference maps, possible labile hydrogen atom positions were identified for each model and refined using LALS. The second model is significantly different from previous proposals based on the crystal structures of cellotetraose, MD simulations of cellulose II, and any potential hydrogen-bonding network in the structure of cellulose II determined in earlier X-ray fiber diffraction studies. The exact localization of the labile hydrogen atoms involved in this bonding, together with their donor and acceptor characteristics, is presented and discussed. This study provides, for the first time

  14. Transcriptional Network Analysis Reveals that AT1 and AT2 Angiotensin II Receptors Are Both Involved in the Regulation of Genes Essential for Glioma Progression

    PubMed Central

    Azevedo, Hátylas; Fujita, André; Bando, Silvia Yumi; Iamashita, Priscila; Moreira-Filho, Carlos Alberto

    2014-01-01

    Gliomas are aggressive primary brain tumors with high infiltrative potential. The expression of Angiotensin II (Ang II) receptors has been associated with poor prognosis in human astrocytomas, the most common type of glioma. In this study, we investigated the role of Angiotensin II in glioma malignancy through transcriptional profiling and network analysis of cultured C6 rat glioma cells exposed to Ang II and to inhibitors of its membrane receptor subtypes. C6 cells were treated with Ang II and specific antagonists of AT1 and AT2 receptors. Total RNA was isolated after three and six hours of Ang II treatment and analyzed by oligonucleotide microarray technology. Gene expression data was evaluated through transcriptional network modeling to identify how differentially expressed (DE) genes are connected to each other. Moreover, other genes co-expressing with the DE genes were considered in these analyses in order to support the identification of enriched functions and pathways. A hub-based network analysis showed that the most connected nodes in Ang II-related networks exert functions associated with cell proliferation, migration and invasion, key aspects for glioma progression. The subsequent functional enrichment analysis of these central genes highlighted their participation in signaling pathways that are frequently deregulated in gliomas such as ErbB, MAPK and p53. Noteworthy, either AT1 or AT2 inhibitions were able to down-regulate different sets of hub genes involved in protumoral functions, suggesting that both Ang II receptors could be therapeutic targets for intervention in glioma. Taken together, our results point out multiple actions of Ang II in glioma pathogenesis and reveal the participation of both Ang II receptors in the regulation of genes relevant for glioma progression. This study is the first one to provide systems-level molecular data for better understanding the protumoral effects of Ang II in the proliferative and infiltrative behavior of

  15. Very deep spectroscopy of the bright Saturn nebula NGC 7009 - II. Analysis of the rich optical recombination spectrum

    NASA Astrophysics Data System (ADS)

    Fang, X.; Liu, X.-W.

    2013-03-01

    In Paper I, we presented a deep, long-slit spectrum of the bright Saturn nebula NGC 7009. Numerous permitted lines emitted by the C+, N+, O+ and Ne+ ions were detected. Gaussian profile fitting to the spectrum yielded more than 1000 lines, the majority of which are optical recombination lines (ORLs) of heavy-element ions. In the current paper, we present a critical analysis of the rich optical recombination spectrum of NGC 7009, in the context of the bi-abundance nebular model proposed by Liu et al. Transitions from individual multiplets are checked carefully for potential blended lines. The observed relative intensities are compared with the theoretical predictions based on high-quality effective recombination coefficients, now available for the recombination line spectrum of a number of heavy-element ions. The possibility of plasma diagnostics using the ORLs of various heavy-element ions is discussed in detail. The line ratios that can be used to determine electron temperature are presented for each ion, although there is still a lack of adequate atomic data and some of the lines are still not detected in the spectrum of NGC 7009 due to weakness and/or line blending. Plasma diagnostics based on the N II and O II recombination spectra both yield electron temperatures close to 1000 K, which is lower than those derived from the collisionally excited line (CEL) ratios (e.g. the [O III] and [N II] nebular-to-auroral line ratios; see Paper I for details) by nearly one order of magnitude. The very low temperatures yielded by the O II and N II ORLs indicate that they originate from very cold regions. The C2+/H+, N2+/H+, O2+/H+ and Ne2+/H+ ionic abundance ratios derived from ORLs are consistently higher, by about a factor of 5, than the corresponding values derived from CELs. In calculating the ORL ionic abundance ratios, we have used the newly available high-quality effective recombination coefficients, and adopted an electron temperature of ˜1000 K, as given by the ORL

  16. In-Situ Analysis of the Phobos Surface Mineralogy by the Mössbauer Spectrometer MIMOS II on Phobos Grunt.

    NASA Astrophysics Data System (ADS)

    Blumers, Mathias; Rodionov, Daniel; Klingelhöfer, Göstar; Evlanov, Evgeny; Bernhardt, Bodo; Fleischer, Iris; Girones-Lopez, Jordi; Maul, Jasmine; Duston, Claude; Shlyk, A.

    Müssbauer spectroscopy is a powerful tool for quantitative mineralogical analysis of Fe bearing materials. The miniature Müssbauer spectrometer MIMOS II [1] is a component of the Athena science payload on board of the two Mars Exploration Rovers currently working on the Martian surface. Both MIMOS instruments are still operational after 6 years of mission with a total integration time over 1 year. The MER mission has proven that Müssbauer spectroscopy is a valuable technique for the in situ exploration of extraterrestrial bodies and the study of Fe-bearing samples [2,3]. Currently MIMOS II is part of scientific payload of the "Phobos-Grunt"-Russian sample return mission to Phobos, one of the moons of Mars. Originally, "Phobos-Grunt" was scheduled to launch in October 2009, but the launch was delayed to 2011 for additional testing of the spacecraft and payload to ensure mission success. Mission goals are: (i) Sample return. for Laboratory analysis of Phobos surface material delivered to Earth; (ii) In situ and remote studies of Phobos surface including analysis of soil samples; (3) Exploration of Phobos and its ambient space from an orbiter. MIMOS II is mounted on the robotic arm (on the landing module). Scientific objectives are: (i) Identification of iron-bearing phases (e.g., oxides, silicates, sulfides, sulfates, and carbonates); (ii) Quantitative measurement of the distribution of iron among those phases; (iii) Quantitative measurement of the distribution of iron among its oxidation states. The Müssbauer spectrometer for "Phobos-Grunt" is based on the MER version [1] with some modifications and improvements. A number of improvements were made to ensure optimal instrument performance at low temperatures (down to -150 C). Acknowledgments: Funded by German Space Agency DLR under contract 50 QM 0703. Support by the Russian Space Agency is acknowledged. References: [1] Klingelhoefer et al., JGR. 108(E12) (2003), [2] Morris et al., JGR111 (2006), [3] Morris et al

  17. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... 46 Shipping 5 2013-10-01 2013-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  18. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2012 CFR

    2012-10-01

    ... 46 Shipping 5 2012-10-01 2012-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  19. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 46 Shipping 5 2011-10-01 2011-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  20. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 46 Shipping 5 2010-10-01 2010-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  1. 46 CFR Figure 1 to Part 150 - Compatibility Chart

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... 46 Shipping 5 2014-10-01 2014-10-01 false Compatibility Chart 1 Figure 1 to Part 150 Shipping COAST GUARD, DEPARTMENT OF HOMELAND SECURITY (CONTINUED) CERTAIN BULK DANGEROUS CARGOES COMPATIBILITY OF CARGOES Pt. 150, Fig. 1 Figure 1 to Part 150—Compatibility Chart EC02FE91.079...

  2. The Effect of Birth Order on Roommate Compatibility

    ERIC Educational Resources Information Center

    Schuh, John H.; Williams, Ondre J.

    1977-01-01

    A group of students were matched on the basis of compatible birth order; another was matched on the basis of conflicting birth order. After a month's experience in a residence hall their compatibility was examined. Students with conflicting birth order were more compatible than those with the same birth order. (Author)

  3. Are Automatic Imitation and Spatial Compatibility Mediated by Different Processes?

    ERIC Educational Resources Information Center

    Cooper, Richard P.; Catmur, Caroline; Heyes, Cecilia

    2013-01-01

    Automatic imitation or "imitative compatibility" is thought to be mediated by the mirror neuron system and to be a laboratory model of the motor mimicry that occurs spontaneously in naturalistic social interaction. Imitative compatibility and spatial compatibility effects are known to depend on different stimulus dimensions--body…

  4. 47 CFR 76.1622 - Consumer education program on compatibility.

    Code of Federal Regulations, 2011 CFR

    2011-10-01

    ... 47 Telecommunication 4 2011-10-01 2011-10-01 false Consumer education program on compatibility. 76... SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1622 Consumer education program on compatibility. Cable system operators shall provide a consumer education program on compatibility matters...

  5. 14 CFR Appendix B to Part 150 - Noise Compatibility Programs

    Code of Federal Regulations, 2014 CFR

    2014-01-01

    ... 14 Aeronautics and Space 3 2014-01-01 2014-01-01 false Noise Compatibility Programs B Appendix B to Part 150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Pt. 150, App. B Appendix B to Part 150—Noise Compatibility Programs Sec. B150.1Scope and...

  6. 14 CFR Appendix B to Part 150 - Noise Compatibility Programs

    Code of Federal Regulations, 2010 CFR

    2010-01-01

    ... 14 Aeronautics and Space 3 2010-01-01 2010-01-01 false Noise Compatibility Programs B Appendix B to Part 150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Pt. 150, App. B Appendix B to Part 150—Noise Compatibility Programs Sec. B150.1Scope and...

  7. 14 CFR Appendix B to Part 150 - Noise Compatibility Programs

    Code of Federal Regulations, 2012 CFR

    2012-01-01

    ... 14 Aeronautics and Space 3 2012-01-01 2012-01-01 false Noise Compatibility Programs B Appendix B to Part 150 Aeronautics and Space FEDERAL AVIATION ADMINISTRATION, DEPARTMENT OF TRANSPORTATION (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Pt. 150, App. B Appendix B to Part 150—Noise Compatibility Programs Sec. B150.1Scope and...

  8. 14 CFR Appendix B to Part 150 - Noise Compatibility Programs

    Code of Federal Regulations, 2013 CFR

    2013-01-01

    ... 14 Aeronautics and Space 3 2013-01-01 2013-01-01 false Noise Compatibility Programs B Appendix B... (CONTINUED) AIRPORTS AIRPORT NOISE COMPATIBILITY PLANNING Pt. 150, App. B Appendix B to Part 150—Noise Compatibility Programs Sec. B150.1Scope and purpose. Sec. B150.3Requirement for noise map. Sec....

  9. 47 CFR 76.1622 - Consumer education program on compatibility.

    Code of Federal Regulations, 2010 CFR

    2010-10-01

    ... 47 Telecommunication 4 2010-10-01 2010-10-01 false Consumer education program on compatibility. 76... SERVICES MULTICHANNEL VIDEO AND CABLE TELEVISION SERVICE Notices § 76.1622 Consumer education program on compatibility. Cable system operators shall provide a consumer education program on compatibility matters...

  10. The Relationship Between Marital Satisfaction and Compatibility With Type 2 Diabetes

    PubMed Central

    Dadgari, Atena; Mazloom, Nahid; Heidari Firouz Abadi, Mohammad Reza; Bagheri, Imane

    2015-01-01

    Background: Marriage is a legal pact between a man and a woman for participating in a social life together which can play an important role in dealing with difficulties. Objectives: This study was carried out to investigate the relationship between marital satisfaction and compatibility with diabetes in patients with type 2 diabetes. Patients and Methods: The study method was descriptive-correctional. The study sample included 160 diabetic patients (103 females and 57 males) who were randomly selected. The instruments used were Enrich marital satisfaction questionnaire and the questionnaire of compatibility with diabetes. In addition, the data were analyzed through descriptive statistics and analysis of variance by SPSS. Results: The result of the study revealed a significant correlation (P = 0.006) between marital satisfaction and compatibility with diabetes in women with type 2 diabetes (r = 0.26). However, this correlation was not significant in men with diabetes. Also, a significant relationship existed between the dimensions of compatibility with diabetes and marital satisfaction in both men and women with diabetes. Conclusions: Marital satisfaction affects compatibility with diabetes in women. Therefore, it might be possible to increase compatibility with diabetes in them by offering specialized interventions as family and couples therapies and giving consultations. PMID:26834807

  11. Rust transformation/rust compatible primers

    NASA Technical Reports Server (NTRS)

    Emeric, Dario A.; Miller, Christopher E.

    1993-01-01

    Proper surface preparation has been the key to obtain good performance by a surface coating. The major obstacle in preparing a corroded or rusted surface is the complete removal of the contaminants and the corrosion products. Sandblasting has been traditionally used to remove the corrosion products before painting. However, sandblasting can be expensive, may be prohibited by local health regulations and is not applicable in every situation. To get around these obstacles, Industry developed rust converters/rust transformers and rust compatible primers (high solids epoxies). The potential use of these products for military equipment led personnel of the Belvoir Research, Development and Engineering Center (BRDEC) to evaluate the commercially available rust transformers and rust compatible primers. Prior laboratory experience with commercially available rust converters, as well as field studies in Hawaii and Puerto Rico, revealed poor performance, several inherent limitations, and lack of reliability. It was obvious from our studies that the performance of rust converting products was more dependent on the amount and type of rust present, as well as the degree of permeability of the coating, than on the product's ability to form an organometallic complex with the rust. Based on these results, it was decided that the Military should develop their own rust converter formulation and specification. The compound described in the specification is for use on a rusted surface before the application of an organic coating (bituminous compounds, primer or topcoat). These coatings should end the need for sandblasting or the removing of the adherent corrosion products. They also will prepare the surface for the application of the organic coating. Several commercially available rust compatible primers (RCP) were also tested using corroded surfaces. All of the evaluated RCP failed our laboratory tests for primers.

  12. Liquid-Oxygen-Compatible Cement for Gaskets

    NASA Technical Reports Server (NTRS)

    Elmore, N. L.; Neale, B. C.

    1984-01-01

    Fluorelastomer and metal bonded reliably by new procedure. To cure fluoroelastomer cement, metal plate/gasket assembly placed in vacuum bag evacuated to minimum vacuum of 27 inches (69 cm) of mercury. Vacuum maintained throughout heating process and until assembly returns to ambient room temperature. Used to seal gaskets and O-rings or used to splice layers of elastomer to form non-standard sized O-rings. Another possible use is to apply protective, liquid-oxygen-compatible coating to metal parts.

  13. Electromagnetic compatibility of nuclear power plants

    SciTech Connect

    Cabayan, H.S.

    1983-01-01

    Lately, there has been a mounting concern about the electromagnetic compatibility of nuclear-power-plant systems mainly because of the effects due to the nuclear electromagnetic pulse, and also because of the introduction of more-sophisticated and, therefore, more-susceptible solid-state devices into the plants. Questions have been raised about the adequacy of solid-state-device protection against plant electromagnetic-interference sources and transients due to the nuclear electromagnetic pulse. In this paper, the author briefly reviews the environment, and the coupling, susceptibility, and vulnerability assessment issues of commercial nuclear power plants.

  14. Rate-Compatible Protograph LDPC Codes

    NASA Technical Reports Server (NTRS)

    Nguyen, Thuy V. (Inventor); Nosratinia, Aria (Inventor); Divsalar, Dariush (Inventor)

    2014-01-01

    Digital communication coding methods resulting in rate-compatible low density parity-check (LDPC) codes built from protographs. Described digital coding methods start with a desired code rate and a selection of the numbers of variable nodes and check nodes to be used in the protograph. Constraints are set to satisfy a linear minimum distance growth property for the protograph. All possible edges in the graph are searched for the minimum iterative decoding threshold and the protograph with the lowest iterative decoding threshold is selected. Protographs designed in this manner are used in decode and forward relay channels.

  15. Advanced satellite design and ISDN compatibility

    NASA Astrophysics Data System (ADS)

    Pelton, Joseph N.

    1992-03-01

    The present evaluation of numerous strategies that can be pursued to upgrade satellite-based communications notes that such services will remain an important option for users even in a world of broadband Integrated Services Digital Network (ISDN) and Asynchronous Transfer Mode (ATM) services. Standards organizations concerned with satellite communications should accordingly develop ISDN and ATM standards that are compatible with satellites, fiber-optics, and hybrid systems, including those standards relating to improving satellite performance in such areas of strategic weakness as onboard processing and artificially intelligent ultrasmall aperture terminals.

  16. Microwave furnace having microwave compatible dilatometer

    DOEpatents

    Kimrey, Jr., Harold D.; Janney, Mark A.; Ferber, Mattison K.

    1992-01-01

    An apparatus for measuring and monitoring a change in the dimension of a sample being heated by microwave energy is described. The apparatus comprises a microwave heating device for heating a sample by microwave energy, a microwave compatible dilatometer for measuring and monitoring a change in the dimension of the sample being heated by microwave energy without leaking microwaves out of the microwave heating device, and a temperature determination device for measuring and monitoring the temperature of the sample being heated by microwave energy.

  17. Compatibility of header materials with pyrotechnic powder

    SciTech Connect

    Weirick, L.J.

    1982-12-01

    The intent of this research program is to qualify several stainless steels, nickel-base alloys and a titanium alloy as candidates for explosive component applications. This report focuses on the compatibility of these materials with pyrotechnic powder. The powder is a combined titanium subhydride-potassium perchlorate mixture, used both wet and dry. Hollow tensile bars were utilized to discern interactions between the metal and powder which underwent accelerated aging. Metallography was employed along with the mechanical property results to characterize the extent of interaction. No degradation in mechanical properties was noted. 6 figures, 6 tables.

  18. Compatible Relaxation and Coarsening in Algebraic Multigrid

    SciTech Connect

    Brannick, J J; Falgout, R D

    2009-09-22

    We introduce a coarsening algorithm for algebraic multigrid (AMG) based on the concept of compatible relaxation (CR). The algorithm is significantly different from standard methods, most notably because it does not rely on any notion of strength of connection. We study its behavior on a number of model problems, and evaluate the performance of an AMG algorithm that incorporates the coarsening approach. Lastly, we introduce a variant of CR that provides a sharper metric of coarse-grid quality and demonstrate its potential with two simple examples.

  19. CMOS-compatible RF MEMS switch

    NASA Astrophysics Data System (ADS)

    Lakamraju, Narendra V.; Kim, Bruce; Phillips, Stephen M.

    2004-08-01

    Mobile technologies have relied on RF switches for a long time. Though the basic function of the switch has remained the same, the way they have been made has changed in the recent past. In the past few years work has been done to use MEMS technologies in designing and fabricating an RF switch that would in many ways replace the electronic and mechanical switches that have been used for so long. The work that is described here is an attempt to design and fabricate an RF MEMS switch that can handle higher RF power and have CMOS compatible operating voltages.

  20. Microwave furnace having microwave compatible dilatometer

    DOEpatents

    Kimrey, H.D. Jr.; Janney, M.A.; Ferber, M.K.

    1992-03-24

    An apparatus for measuring and monitoring a change in the dimension of a sample being heated by microwave energy is described. The apparatus comprises a microwave heating device for heating a sample by microwave energy, a microwave compatible dilatometer for measuring and monitoring a change in the dimension of the sample being heated by microwave energy without leaking microwaves out of the microwave heating device, and a temperature determination device for measuring and monitoring the temperature of the sample being heated by microwave energy. 2 figs.

  1. Observational Analysis of Tropical Cyclone Formation. Part II: Comparison of Non-Developing versus Developing Systems.

    NASA Astrophysics Data System (ADS)

    McBride, John L.; Zehr, Raymond

    1981-06-01

    The thermodynamic and dynamic fields surrounding the composite tropical weather systems described in Part I (McBride, 1981a) are examined for differences between non-developing and developing systems. The main findings are as follows: (i) Both non-developing and developing systems are warm core in the upper levels. The temperature (and height) gradients are more pronounced in the developing system, but the magnitudes are so small that the differences would be difficult to measure for individual systems. (ii) The developing or pre-typhoon cloud cluster exists in a warmer atmosphere over a large horizontal scale, for example, out to 8° latitude radius in all directions. (iii) There is no obvious difference in vertical stability for moist convection between the systems. (iv) There is no obvious difference in moisture content or moisture gradient. (v) Pre-typhoon and pre-hurricane systems are located in large areas of high values of low-level relative vorticity. The low-level vorticity in the vicinity of a developing cloud cluster is approximately twice as large as that observed with non-developing cloud clusters. (vi) Mean divergence and vertical motion for the typical western Atlantic weather system are well below the magnitudes found in pre-tropical storm systems. (vii) Once a system has sufficient divergence to maintain 100 mb or more per day upward vertical motion over a 4° radius area, there appears to be no relationship between the amount of upward vertical velocity and the potential of the system for development. (viii) Cyclogenesis takes place under conditions of zero vertical wind shear near the system center. (ix) There is a requirement for large positive zonal shear to the north and negative zonal shear close to the south of a developing system. There is also a requirement for southerly shear to the west and northerly shear to the east. The scale of this shear pattern is over a 10° latitude radius circle with maximum amplitude at 6° radius.Under the

  2. EXTENDED ANALYSIS OF THE SPECTRUM OF SINGLY IONIZED CHROMIUM (Cr II)

    SciTech Connect

    Sansonetti, Craig J.; Nave, Gillian

    2014-08-01

    We have made new observations of the spectrum of singly ionized chromium (Cr II) in the region 2850-37900 Å with the National Institute of Standards and Technology 2 m Fourier transform spectrometer. These data extend our previously reported observations in the near-ultra-violet region. We present a comprehensive list of more than 5300 Cr II lines classified as transitions among 456 even and 457 odd levels, 179 of which are newly located in this work. Using highly excited levels of the 3d {sup 4}({sup 5} D)5g, 3d {sup 4}({sup 5} D)6g, and 3d {sup 4}({sup 5}D)6h configurations, we derive an improved ionization energy of 132971.02 ± 0.12 cm{sup –1} (16.486305 ± 0.000015 eV)

  3. Extended Analysis of the Spectrum of Singly Ionized Chromium (Cr II)

    NASA Astrophysics Data System (ADS)

    Sansonetti, Craig J.; Nave, Gillian

    2014-08-01

    We have made new observations of the spectrum of singly ionized chromium (Cr II) in the region 2850-37900 Å with the National Institute of Standards and Technology 2 m Fourier transform spectrometer. These data extend our previously reported observations in the near-ultra-violet region. We present a comprehensive list of more than 5300 Cr II lines classified as transitions among 456 even and 457 odd levels, 179 of which are newly located in this work. Using highly excited levels of the 3d 4(5 D)5g, 3d 4(5 D)6g, and 3d 4(5D)6h configurations, we derive an improved ionization energy of 132971.02 ± 0.12 cm-1 (16.486305 ± 0.000015 eV).

  4. RF Feedback Analysis for 4 cavities per klystron in PEP-II

    SciTech Connect

    Corredoura, P.; Tighe, R.

    1994-06-01

    Lattice changes in the PEP-II high energy ring have made the concept of driving four cavities with a single klystron an attractive option. This paper examines the topology from a RF feedback point of view. Sources of error are identified and their magnitudes are estimated. The effect on the performance of the longitudinal impedance reducing feedback loops is calculated using control theory and Mathematica.

  5. Analysis of JSI TRIGA MARK II reactor physical parameters calculated with TRIPOLI and MCNP.

    PubMed

    Henry, R; Tiselj, I; Snoj, L

    2015-03-01

    New computational model of the JSI TRIGA Mark II research reactor was built for TRIPOLI computer code and compared with existing MCNP code model. The same modelling assumptions were used in order to check the differences of the mathematical models of both Monte Carlo codes. Differences between the TRIPOLI and MCNP predictions of keff were up to 100pcm. Further validation was performed with analyses of the normalized reaction rates and computations of kinetic parameters for various core configurations. PMID:25576735

  6. Analysis of RFSA Campaign No.2 Dissolver Solution for Hg(I) and Hg(II)

    SciTech Connect

    Holcomb, H.P.

    2001-05-17

    TA 2-1083, under which RFSA processing is conducted, calls for a nominal mercuric ion concentration in the dissolver solution of 0.006M with a maximum of 0.01 M. The second RFSA campaign operated according to these guidelines with the initial Hg(II) concentration being 0.0068 M. Part of this study is to ascertain optimum excess Hg(I) for chloride removal.

  7. The sustentaculum tali screw fixation for the treatment of Sanders type II calcaneal fracture: A finite element analysis

    PubMed Central

    Pang, Qing-Jiang; Yu, Xiao; Guo, Zong-Hui

    2014-01-01

    Objective: In the surgery of calcaneal fracture, whether the sustentaculum tali screw should always be placed is widely controversial. The aim of this study was to explore the necessity and function of the sustentaculum tali screw placement for the treatment of Sanders type II calcaneal fracture. Methods: The finite element analysis was used in this study. After the establishment of the finite element model of Sanders type II calcaneal fracture, the two internal fixation simulations were designed. In one model, the AO calcaneal plate was simulated on the lateral side of the calcanues with 7 screws being fixated at different position of the plate. In the other model, the calcaneus was fixated with the same AO calcaneal plate together with an additional screw being infiltrated into the sustentaculum tali. The two models were simulated under the same loading and the displacement of the fracture line and the stress distribution in the two models were calculated respectively. Results: The maximum principal stress focused on the cortical bone of sustentaculum tali in both the models under the same loading. The displacement of the fracture line, the maximum principal stress of calcaneus and internal fixation system in the model with sustentaculum screw fixation were smaller than that in the model without sustentaculum screw fixation. The stress in the model with sustentaculum screw fixation was more dispersed. Conclusions: The placement of sustentaculum tali screw is essential for fixation of type II calcaneal fracture to achieve the biomechanical stability. PMID:25225534

  8. Acoustical analysis and modeling of reciprocating compressors, noise produced by gas pulsation, using four-pole method. II

    NASA Astrophysics Data System (ADS)

    Herfat, Ali T.; Seel, Robert V.

    2003-04-01

    Presented in Paper II is the noise analysis of reciprocating compressors (such as air conditioning and refrigeration reciprocating compressors) using the four-pole method. The gas pulsation noise inside compressor head cavities, mufflers, and through-valves can be analyzed by applying the FPM. This method formulates the characteristics of acoustic elements by establishing a relationship between their input and output gas pressures and volume flow rates. When the acoustic elements in the system (compressor) are connected at points between them, the FPM allows an easy assembly of element equations to obtain system acoustical model.

  9. Pollen Tube Growth and Self-Compatibility in Almond

    PubMed Central

    Socias i Company, Rafel; Kodad, Ossama; Fernández i Martí, Àngel; Alonso, José M.

    2013-01-01

    Although pollen tube growth has been an important criterion for self-compatibility evaluation in almond, there is not a clear-cut separation between positive and negative growth of pollen tubes in the different genotypes. The examination of pollen tube growth after selfing almond seedlings has allowed establishing different levels of compatibility, but not a clear-cut separation between self-compatible (SC) and self-incompatible (SI) genotypes, related to the presence of pseudo-self-compatibility in almond. Consequently, a relationship between pollen tube growth and self-compatibility in almond may be established for evaluating the seedlings in breeding programs. PMID:27137365

  10. Integrated environmentally compatible soldering technologies. Final report

    SciTech Connect

    Hosking, F.M.; Frear, D.R.; Iman, R.L.; Keicher, D.M.; Lopez, E.P.; Peebles, H.C.; Sorensen, N.R.; Vianco, P.T.

    1994-05-01

    Chemical fluxes are typically used during conventional electronic soldering to enhance solder wettability. Most fluxes contain very reactive, hazardous constituents that require special storage and handling. Corrosive flux residues that remain on soldered parts can severely degrade product reliability. The residues are removed with chlorofluorocarbon (CFC), hydrochlorofluorocarbon (HCFC), or other hazardous solvents that contribute to ozone depletion, release volatile organic compounds into the atmosphere, or add to the solvent waste stream. Alternative materials and processes that offer the potential for the reduction or elimination of cleaning are being developed to address these environmental issues. Timing of the effort is critical, since the targeted chemicals will soon be heavily taxed or banned. DOE`s Office of Environmental Restoration and Waste Management (DOE/EM) has supported Sandia National Laboratories` Environmentally Conscious Manufacturing Integrated Demonstration (ECMID). Part of the ECM program involves the integration of several environmentally compatible soldering technologies for assembling electronics devices. Fluxless or {open_quotes}low-residue/no clean{close_quotes} soldering technologies (conventional and ablative laser processing, controlled atmospheres, ultrasonic tinning, protective coatings, and environmentally compatible fluxes) have been demonstrated at Sandia (SNL/NM), the University of California at Berkeley, and Allied Signal Aerospace-Kansas City Division (AS-KCD). The university demonstrations were directed under the guidance of Sandia staff. Results of the FY93 Soldering ID are presented in this report.

  11. Mixed waste chemical compatibility with packaging components

    SciTech Connect

    Nigrey, P.J.; Conroy, M.; Blalock, L.B.

    1994-05-01

    In this paper, a chemical compatibility testing program for packaging of mixed wastes at will be described. We will discuss the choice of four y-radiation doses, four time durations, four temperatures and four waste solutions to simulate the hazardous waste components of mixed wastes for testing materials compatibility of polymers. The selected simulant wastes are (1) an aqueous alkaline mixture of sodium nitrate and sodium nitrite; (2) a chlorinated hydrocarbon mixture; (3) a simulant liquid scintillation fluid; and (4) a mixture of ketones. A selection of 10 polymers with anticipated high resistance to one or more of these types of environments are proposed for testing as potential liner or seal materials. These polymers are butadiene acrylonitrile copolymer, cross-linked polyethylene, epichlorhyarin, ethylene-propylene rubber, fluorocarbon, glass-filled tetrafluoroethylene, high-density poly-ethylene, isobutylene-isoprene copolymer, polypropylene, and styrene-butadiene rubber. We will describe the elements of the testing plan along with a metric for establishing time resistance of the packaging materials to radiation and chemicals.

  12. Nonmetallic Material Compatibility with Liquid Fluorine

    NASA Technical Reports Server (NTRS)

    Price, Harold G , Jr; Douglass, Howard W

    1957-01-01

    Static tests were made on the compatibility of liquid fluorine with several nonmetallic materials at -3200 F and at pressures of 0 and 1500 pounds per square inch gage. The results are compared with those from previous work with gaseous fluorine at the same pressures, but at atmospheric temperature. In general, although environmental effects were not always consistent, reactivity was least with the low-temperature, low-pressure liquid fluorine. Reactivity was greatest with the warm, high-pressure gaseous fluorine. None of the liquids and greases tested was found to be entirely suitable for use in fluorine systems. Polytrifluorochloroethylene and N-43, the formula for which is (C4F9)3N, did not react with liquid fluorine at atmospheric pressure or 1500 pounds per square inch gage under static conditions, but they did react when injected into liquid fluorine at 1500 pounds per square inch gage; they also reacted with gaseous fluorine at 1500 pounds per square inch gage. While water did not react with liquid fluorine at 1500 pounds per square inch gage, it is known to react violently with fluorine under other conditions. The pipe-thread lubricant Q-Seal did not react with liquid fluorine, but did react with gaseous fluorine at 1500 pounds per square inch gage. Of the solids, ruby (Al2O3) and Teflon did not react under the test conditions. The results show that the compatibility of fluorine with nonmetals depends on the state of the fluorine and the system design.

  13. Compatibility considerations in parenteral nutrient solutions.

    PubMed

    Niemiec, P W; Vanderveen, T W

    1984-05-01

    Information on compatibility of nutrients and drugs with parenteral nutrient (PN) solutions is reviewed and evaluated. Precipitation of calcium phosphate when calcium and phosphate salts are added can be affected by pH, amino acid concentration, amino acid product, temperature, sequence of additives, specific salt used, and time since admixture; precipitate formation can occur gradually over 24 hours. Insulin is chemically stable in PN solutions, but adsorption to the infusion system can cause decreased availability. Poor delivery of vitamin A via PN solutions has been reported. The sodium bisulfite content of amino acid injections may cause degradation of thiamine, but studies simulating clinical use are needed. Folic acid stability in PN solutions has been demonstrated, and phytonadione appears to be stable. Drug administration via PN solutions may be advantageous when fluid intake is restricted or peripheral vein access is limited and in home PN therapy. Summarized are results of studies involving heparin, cimetidine hydrochloride, aminophylline, amphotericin B, iron dextran, hydrochloric acid, corticosteroids, narcotics, metoclopramide, digoxin, and fluorouracil. Many antibiotics are probably stable, especially when administered by co-infusion rather than by direct mixture in the PN solution container. When lipids are mixed in the same container with amino acid-dextrose solutions, compatibility and stability of electrolytes, vitamins, and trace elements must be reassessed. Practical research is needed, and availability of additives should be studied in specific patient populations and for specific PN formulations. Valid conclusions are dependent on careful study design. PMID:6328980

  14. Glucosylated polymeric nanoparticles: a sweetened approach against blood compatibility paradox.

    PubMed

    Thasneem, Y M; Sajeesh, S; Sharma, Chandra P

    2013-08-01

    Surface functionalization strategies in generating stealth nano-carriers have garnered considerable attention in pharmaceutical research. In this regard, our investigation reports on the preparation and evaluation of glucose decorated poly lactic-co-glycolic acid (PLGA) nanoparticles as blood compatible nanoparticulate drug delivery system, with enhanced cellular uptake. Terminal carboxylic acid groups on PLGA were modified with the amino group of glucosamine and nanoparticles were generated by modified solvent diffusion (nano-precipitation) technique. Detailed in vitro experiments were performed to evaluate the eminence of glucose functionalization over unmodified nanoparticles, in terms of their hemocompatibility and cellular uptake. Glucosylation was confirmed by NMR and FTIR spectroscopy; PLGA and modified particles had average size in the range of 125nm. Glucosylation was an effective strategy in reducing plasma protein adsorption, complement activation and platelet plugging of PLGA nanoparticles. PLGA and their glucose modified versions were quite compatible with the blood cells and were non-cytotoxic. Moreover the uptake behaviour of glucose modified PLGA nanoparticles were enhanced in comparison to standard PLGA nanoparticles as emphasized by the z stacking analysis following confocal imaging. Precisely the stealth properties of glucose modified PLGA nanoparticles (PLGA-Glu), with enhanced cellular internalization, seems to be a safe and efficient system for intravenous drug delivery applications. PMID:23563302

  15. Effect of Time on Gypsum-Impression Material Compatibility

    NASA Astrophysics Data System (ADS)

    Won, John Boram

    The purpose of this study was to evaluate the compatibility of dental gypsum with three recently introduced irreversible hydrocolloid (alginate) alternatives. The test materials were Alginot® (Kerr™), Position Penta Quick® (3M ESPE™) and Silgimix ® (Sultan Dental™). The irreversible hydrocolloid impression material, Jeltrate Plus antimicrobial® (Dentsply Caulk™) served as the control. Materials and Methods: Testing of materials was conducted in accordance with ANSI/ADA Specification No. 18 for Alginate Impression Materials. Statistical Analysis: The 3-Way ANOVA test was used to analyze measurements between different time points at a significance level of (p < 0.05). Outcome: It was found that there was greater compatibility between gypsum and the alternative materials over time than the traditional irreversible hydrocolloid material that was tested. A statistically significant amount of surface change/incompatibility was found over time with the combination of the dental gypsum products and the control impression material (Jeltrate Plus antimicrobial®).

  16. Compatibility Assessment of Advanced Stainless Steels in Sodium

    SciTech Connect

    Pawel, Steven J

    2012-01-01

    Type 316L stainless steel capsules containing commercially pure sodium and miniature tensile specimens of HT-UPS (austenitic, 14Cr-16Ni), NF-616 (ferritic/martensitic, 9Cr-2W-0.5Mo), or 316L (austenitic, 17Cr-10Ni-2Mo) stainless steel were exposed at 600 or 700 C for 100 and 400 h as a screening test for compatibility. Using weight change, tensile testing, and metallographic analysis, HT-UPS and 316L were found to be largely immune to changes resulting from sodium exposure, but NF-616 was found susceptible to substantial decarburization at 700 C. Subsequently, two thermal convection loops (TCLs) constructed of 316L and loaded with commercially pure sodium and miniature tensile specimens of HT-UPS and 316L were operated for 2000 h each one between 500 and 650 C, the other between 565 and 725 C at a flow rate of about 1.5 cm/s. Changes in specimen appearance, weight, and tensile properties were observed to be very minor in all cases, and there was no metallographic evidence of microstructure changes, composition gradients, or mass transfer resulting from prolonged exposure in a TCL. Thus, it appears that HT-UPS and 316L stainless steels are similarly compatible with commercially pure sodium under these exposure conditions.

  17. Insights from computational analysis of full-length β-ketoacyl-[ACP] synthase-II cDNA isolated from American and African oil palms

    PubMed Central

    Bhore, Subhash J.; Cha, Thye S.; Amelia, Kassim; Shah, Farida H.

    2014-01-01

    Background: Palm oil derived from fruits (mesocarp) of African oil palm (Elaeis guineensis Jacq. Tenera) and American oil palm (E. oleifera) is important for food industry. Due to high yield, Elaeis guineensis (Tenera) is cultivated on commercial scale, though its oil contains high (~54%) level of saturated fatty acids. The rate-limiting activity of beta-ketoacyl-[ACP] synthase-II (KAS-II) is considered mainly responsible for the high (44%) level of palmitic acid (C16:0) in the oil obtained from E. guineensis. Objective: The objective of this study was to annotate KAS-II cDNA isolated from American and African oil palms. Materials and Methods: The full-length E. oleifera KAS-II (EoKAS-II) cDNA clone was isolated using random method of gene isolation. Whereas, the E. guineensis KAS-II (EgTKAS-II) cDNA was isolated using reverse transcriptase polymerase chain reaction (RT-PCR) technique; and missing ends were obtained by employing 5’and 3’ RACE technique. Results: The results show that EoKAS-II and EgTKAS-II open reading frames (ORFs) are of 1689 and 1721 bp in length, respectively. Further analysis of the both EoKAS-II and EgTKAS-II predicted protein illustrates that they contains conserved domains for ‘KAS-I and II’, ‘elongating’ condensing enzymes, ‘condensing enzymes super-family’, and ‘3-oxoacyl-[ACP] synthase II’. The predicted protein sequences shows 95% similarity with each other. Consecutively, the three active sites (Cys, His, and His) were identified in both proteins. However, difference in positions of two active Histidine (His) residues was noticed. Conclusion: These insights may serve as the foundation in understanding the variable activity of KAS-II in American and African oil palms; and cDNA clones could be useful in the genetic engineering of oil palms. PMID:24678202

  18. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2013 CFR

    2013-10-01

    ... affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the Finding Aids... potential compatibility problems, this commodity is not assigned to a specific group in Figure 1 to 46 CFR part 150 (Compatibility Chart). 2 See Appendix I to 46 CFR part 150 (Exceptions to the Chart)....

  19. 46 CFR Table II to Part 150 - Grouping of Cargoes

    Code of Federal Regulations, 2014 CFR

    2014-10-01

    ... affecting Table II to part 150, see the List of CFR Sections Affected, which appears in the Finding Aids... potential compatibility problems, this commodity is not assigned to a specific group in Figure 1 to 46 CFR part 150 (Compatibility Chart). 2 See Appendix I to 46 CFR part 150 (Exceptions to the Chart)....

  20. Conditions for compatibility of quantum-state assignments

    SciTech Connect

    Caves, Carlton M.; Fuchs, Christopher A.; Schack, Ruediger

    2002-12-01

    Suppose N parties describe the state of a quantum system by N possibly different density operators. These N state assignments represent the beliefs of the parties about the system. We examine conditions for determining whether the N state assignments are compatible. We distinguish two kinds of procedures for assessing compatibility, the first based on the compatibility of the prior beliefs on which the N state assignments are based and the second based on the compatibility of predictive measurement probabilities they define. The first procedure leads to a compatibility criterion proposed by Brun, Finkelstein, and Mermin [BFM, Phys. Rev. A 65, 032315 (2002)]. The second procedure leads to a hierarchy of measurement-based compatibility criteria which is fundamentally different from the corresponding classical situation. Quantum mechanically none of the measurement-based compatibility criteria is equivalent to the BFM criterion.

  1. Laser-Induced Transient Grating Analysis of Dynamics of Interaction between Sensory Rhodopsin II D75N and the HtrII Transducer

    PubMed Central

    Inoue, Keiichi; Sasaki, Jun; Spudich, John L.; Terazima, Masahide

    2007-01-01

    The interaction between sensory rhodopsin II (SRII) and its transducer HtrII was studied by the time-resolved laser-induced transient grating method using the D75N mutant of SRII, which exhibits minimal visible light absorption changes during its photocycle, but mediates normal phototaxis responses. Flash-induced transient absorption spectra of transducer-free D75N and D75N joined to 120 amino-acid residues of the N-terminal part of the SRII transducer protein HtrII (ΔHtrII) showed only one spectrally distinct K-like intermediate in their photocycles, but the transient grating method resolved four intermediates (K1–K4) distinct in their volumes. D75N bound to HtrII exhibited one additional slower kinetic species, which persists after complete recovery of the initial state as assessed by absorption changes in the UV-visible region. The kinetics indicate a conformationally changed form of the transducer portion (designated Tr*), which persists after the photoreceptor returns to the unphotolyzed state. The largest conformational change in the ΔHtrII portion was found to cause a ΔHtrII-dependent increase in volume rising in 8 μs in the K4 state and a drastic decrease in the diffusion coefficient (D) of K4 relatively to those of the unphotolyzed state and Tr*. The magnitude of the decrease in D indicates a large structural change, presumably in the solvent-exposed HAMP domain of ΔHtrII, where rearrangement of interacting molecules in the solvent would substantially change friction between the protein and the solvent. PMID:17189313

  2. Equilibrium analysis of aggregation behavior in the solvent extraction of Cu(II) from sulfuric acid by didodecylnaphthalene sulfonic acid

    SciTech Connect

    Moyer, B.A.; Baes, C.F. Jr.; Case, G.N.; Lumetta, G.J.; Wilson, N.M.

    1993-01-01

    By use of the principles of equilibrium analysis, the liquid-liquid cation exchange of Cu(II) from aqueous sulfuric acid at 25{degrees}C by didodecylnaphthalenesulfonic acid (HDDNS) in toluene may be understood in terms of small hydrated aggregated species in the organic phase. Extraction data were measured as a function of organic-phase HDDNS molarity (1.0 {times} 10{sup {minus}4} to 1.0 {times} 10{sup {minus}1}), aqueous copper(II) sulfate molarity (1.2 {times} 10{sup {minus}8} to 1.3 {times} 10{sup {minus}2}), and aqueous sulfuric acid molarity (0.03 to 6.0). Graphical analysis of linear regions of the data support a model in which organic-phase aggregates of HDDNS function by cation exchange to incorporate Cu(II) ions with no apparent change in aggregation number at low loading. Supporting FTIR spectra and water-content measurements of HDDNS solutions in toluene show that the HDDNS aggregates are highly hydrated. By use of the computer program SXLSQA, a comprehensive equilibrium model was developed with inclusion of activity effects. Aqueous-phase activity coefficients and degree of aqueous bisulfate formation were estimated by use of the Pitzer treatment. Organic-phase nonideality was estimated by the Hildebrand-Scott treatment and was shown to be a negligible effect under the conditions tested. Excluding aqueous sulfuric acid molarities greater than 1, it was possible to model the data to within experimental error by assuming only the equilibrium extraction of Cu{sup 2+} ion by the aggregate (HDDNS){sub 4}(H{sub 2}O){sub 22} and the equilibrium dissociation of (HDDNS){sub 4}(H{sub 2}O){sub 22} to the monomer. The dependence of Cu(II) distribution on aqueous sulfuric acid molarity was shown to be quantitatively consistent with a cation-exchange process. In comparison with the graphical approach, the computer analysis allows comprehensive model testing over large, nonlinear data sets and eliminates the need to make limiting assumptions.

  3. Analysis of Operation Dominic II SMALL BOY radiological and meteorological data

    SciTech Connect

    Quinn, V.E., Kennedy, N.C.; Steadman, C.R.

    1984-08-01

    This report describes the Weather Service Nuclear Support Office (WSNSO) analyses of the radiological and meteorological data collected for the Operation Dominic II nuclear test SMALL BOY. Inconsistencies in the radiological data and their resolution are discussed. The methods of estimating fallout-arrival times are discussed. The meteorological situation on D-day and a few days following are described. A comparison of the fallout patterns resulting from these analyses and earlier (1966) analyses is presented. The radiological data used to derive the fallout pattern in this report are tabulated in an appendix. 11 references, 20 figures.

  4. Picazoplatin, an Azide-Containing Platinum(II) Derivative for Target Analysis by Click Chemistry

    PubMed Central

    White, Jonathan D.; Osborn, Maire F.; Moghaddam, Alan D.; Guzman, Lindsay E.; Haley, Michael M.; DeRose, Victoria J.

    2014-01-01

    Despite the broad use of platinum-based chemotherapeutics, identification of their full range of cellular targets remains a significant challenge. In order to identify, visualize, and isolate cellular targets of Pt(II) complexes, we have modified the chemotherapeutic drug picoplatin with an azide moiety for subsequent click reactivity. The new compound picazoplatin readily binds DNA and RNA oligonucleo-tides and undergoes facile post-labeling click reactions to alkyne-fluorophore conjugates. Pt-fluorophore click reactions in ribosomal RNA purified from drug-treated S. cerevisiae demonstrate its potential for future in vivo efforts. PMID:23879391

  5. Characterisation and optimisation of the new Prompt Gamma-ray Activation Analysis (PGAA) facility at FRM II

    NASA Astrophysics Data System (ADS)

    Canella, Lea; Kudějová, Petra; Schulze, Ralf; Türler, Andreas; Jolie, Jan

    2011-04-01

    At the research reactor Forschungs-Neutronenquelle Heinz Maier-Leibnitz (FRM II) a new Prompt Gamma-ray Activation Analysis (PGAA) facility was installed. The instrument was originally built and operating at the spallation source at the Paul Scherrer Institute in Switzerland. After a careful re-design in 2004-2006, the new PGAA instrument was ready for operation at FRM II. In this paper the main characteristics and the current operation conditions of the facility are described. The neutron flux at the sample position can reach up 6.07×1010 [cm-2 s-1], thus the optimisation of some parameters, e.g. the beam background, was necessary in order to achieve a satisfactory analytical sensitivity for routine measurements. Once the optimal conditions were reached, detection limits and sensitivities for some elements, like for example H, B, C, Si, or Pb, were calculated and compared with other PGAA facilities. A standard reference material was also measured in order to show the reliability of the analysis under different conditions at this instrument.

  6. Fukushima Daiichi Unit 1 Uncertainty Analysis-Exploration of Core Melt Progression Uncertain Parameters-Volume II.

    SciTech Connect

    Denman, Matthew R.; Brooks, Dusty Marie

    2015-08-01

    Sandia National Laboratories (SNL) has conducted an uncertainty analysi s (UA) on the Fukushima Daiichi unit (1F1) accident progression wit h the MELCOR code. Volume I of the 1F1 UA discusses the physical modeling details and time history results of the UA. Volume II of the 1F1 UA discusses the statistical viewpoint. The model used was developed for a previous accident reconstruction investigation jointly sponsored by the US Department of Energy (DOE) and Nuclear Regulatory Commission (NRC). The goal of this work was to perform a focused evaluation of uncertainty in core damage progression behavior and its effect on key figures - of - merit (e.g., hydrogen production, fraction of intact fuel, vessel lower head failure) and in doing so assess the applicability of traditional sensitivity analysis techniques .

  7. Self-Shielding Correlation of Foil Activation Neutron Spectra Analysis by SAND-II.

    Energy Science and Technology Software Center (ESTSC)

    2008-11-21

    Version 00 SELFS-3 corrects for the influence of the self-shielding effect in neutron spectrum determinations by means of the multifoil activation method. It is used in combination with the SAND-II program for unfolding the responses of an irradiated set of activation detectors in 620 groups. The program SELFS can calculate a corrected 620 group cross section data set for specified reactions used in the SAND-II library, and for specified foil thicknesses. This procedure requires nomore » additional assumption on the shape of the neutron spectrum and on other experimental conditions, but only some foil characteristics (reaction type, material composition, foil thickness). Application of this procedure is possible when multigroup unfolding programs are used with suitably small energy intervals. This code system was developed in the 1970’s at Reactor Centrum Nederland, Petten, The Netherlands, and was contributed to RSICC through the NEA Data Bank. No changes were made to the package when it was released by RSICC in 2008. Modifications will be required to run SELFS-3 on current computer systems.« less

  8. Transition Region Explosive Events in He II 304Å: Observation and Analysis

    NASA Astrophysics Data System (ADS)

    Rust, Thomas; Kankelborg, Charles C.

    2016-05-01

    We present examples of transition region explosive events observed in the He II 304Å spectral line with the Multi Order Solar EUV Spectrograph (MOSES). With small (<5000 km) spatial scale and large non-thermal (100-150 km/s) velocities these events satisfy the observational signatures of transition region explosive events. Derived line profiles show distinct blue and red velocity components with very little broadening of either component. We observe little to no emission from low velocity plasma, making the plasmoid instability reconnection model unlikely as the plasma acceleration mechanism for these events. Rather, the single speed, bi-directional jet characteristics suggested by these data are consistent with acceleration via Petschek reconnection.Observations were made during the first sounding rocket flight of MOSES in 2006. MOSES forms images in 3 orders of a concave diffraction grating. Multilayer coatings largely restrict the passband to the He II 303.8Å and Si XI 303.3Å spectral lines. The angular field of view is about 8.5'x17', or about 20% of the solar disk. These images constitute projections of the volume I(x,y,λ), the intensity as a function of sky plane position and wavelength. Spectral line profiles are recovered via tomographic inversion of these projections. Inversion is carried out using a multiplicative algebraic reconstruction technique.

  9. Neutral "Cp-Free" Silyl-Lanthanide(II) Complexes: Synthesis, Structure, and Bonding Analysis.

    PubMed

    Zitz, Rainer; Hlina, Johann; Gatterer, Karl; Marschner, Christoph; Szilvási, Tibor; Baumgartner, Judith

    2015-07-20

    Complexes featuring lanthanide silicon bonds represent a research area still in its infancy. Herein, we report a series of Cp-free lanthanide (+II) complexes bearing σ-bonded silyl ligands. By reactions of LnI2 (Ln = Yb, Eu, Sm) either with a 1,4-oligosilanyl dianion [K-Si(SiMe3)2SiMe2SiMe2Si(SiMe3)2-K)] (1) or with 2 (Me3Si)3SiK (3) the corresponding neutral metallacyclopentasilanes ({Me2Si(Me3Si)2Si}2)Ln·(THF)4 (Ln = Yb (2a), Eu (2b), Sm (2c)), or the disilylated complexes ({Me3Si}3Si)2Ln·(THF)3 (Ln = Yb (4a), Eu (4b), Sm (4c)), were selectively obtained. Complexes 2b, 2c, 4b, and 4c represent the first examples of structurally characterized Cp-free Eu and Sm complexes with silyl ligands. In both series, a linear correlation was observed between the Ln-Si bond lengths and the covalent radii of the corresponding lanthanide metals. Density functional theory calculations were also carried out for complexes 2a-c and 4a-c to elucidate the bonding situation between the Ln(+II) centers and Si. PMID:26132550

  10. Self-Shielding Correlation of Foil Activation Neutron Spectra Analysis by SAND-II.

    SciTech Connect

    KONDO, IKUO

    2008-11-21

    Version 00 SELFS-3 corrects for the influence of the self-shielding effect in neutron spectrum determinations by means of the multifoil activation method. It is used in combination with the SAND-II program for unfolding the responses of an irradiated set of activation detectors in 620 groups. The program SELFS can calculate a corrected 620 group cross section data set for specified reactions used in the SAND-II library, and for specified foil thicknesses. This procedure requires no additional assumption on the shape of the neutron spectrum and on other experimental conditions, but only some foil characteristics (reaction type, material composition, foil thickness). Application of this procedure is possible when multigroup unfolding programs are used with suitably small energy intervals. This code system was developed in the 1970’s at Reactor Centrum Nederland, Petten, The Netherlands, and was contributed to RSICC through the NEA Data Bank. No changes were made to the package when it was released by RSICC in 2008. Modifications will be required to run SELFS-3 on current computer systems.

  11. Neutral “Cp-Free” Silyl-Lanthanide(II) Complexes: Synthesis, Structure, and Bonding Analysis

    PubMed Central

    2015-01-01

    Complexes featuring lanthanide silicon bonds represent a research area still in its infancy. Herein, we report a series of Cp-free lanthanide (+II) complexes bearing σ-bonded silyl ligands. By reactions of LnI2 (Ln = Yb, Eu, Sm) either with a 1,4-oligosilanyl dianion [K-Si(SiMe3)2SiMe2SiMe2Si(SiMe3)2-K)] (1) or with 2 (Me3Si)3SiK (3) the corresponding neutral metallacyclopentasilanes ({Me2Si(Me3Si)2Si}2)Ln·(THF)4 (Ln = Yb (2a), Eu (2b), Sm (2c)), or the disilylated complexes ({Me3Si}3Si)2Ln·(THF)3 (Ln = Yb (4a), Eu (4b), Sm (4c)), were selectively obtained. Complexes 2b, 2c, 4b, and 4c represent the first examples of structurally characterized Cp-free Eu and Sm complexes with silyl ligands. In both series, a linear correlation was observed between the Ln–Si bond lengths and the covalent radii of the corresponding lanthanide metals. Density functional theory calculations were also carried out for complexes 2a–c and 4a–c to elucidate the bonding situation between the Ln(+II) centers and Si. PMID:26132550

  12. Nonlinear soil-structure interaction analysis of SIMQUAKE II. Final report

    SciTech Connect

    Vaughan, D.K.; Isenberg, J.

    1982-04-01

    This report describes an analytic method for modeling of soil-structure interaction (SSI) for nuclear power plants in earthquakes and discusses its application to SSI analyses of SIMQUAKE II. The method is general and can be used to simulate a three-dimensional structural geometry, nonlinear site characteristics and arbitrary input ground shaking. The analytic approach uses the soil island concept to reduce SSI models to manageable size and cost. Nonlinear constitutive behavior of the soil is represented by the nonlinear, kinematic cap model. In addition, a debonding-rebonding soil-structure interface model is utilized to represent nonlinear effects which singificantly alter structural response in the SIMQUAKE tests. STEALTH, an explicit finite difference code, is used to perform the dynamic, soil-structure interaction analyses. Several two-dimensional posttest SSI analyses of model containment structures in SIMQUAKE II are performed and results compared with measured data. These analyses qualify the analytic method. They also show the importance of including debonding-rebonding at the soil-structure interface. Sensitivity of structural response to compaction characteristics of backfill material is indicated.

  13. Single-molecule analysis of DNA uncoiling by a type II topoisomerase

    NASA Astrophysics Data System (ADS)

    Strick, Terence R.; Croquette, Vincent; Bensimon, David

    2000-04-01

    Type II DNA topoisomerases are ubiquitous ATP-dependent enzymes capable of transporting a DNA through a transient double-strand break in a second DNA segment. This enables them to untangle DNA and relax the interwound supercoils (plectonemes) that arise in twisted DNA. In vivo, they are responsible for untangling replicated chromosomes and their absence at mitosis or meiosis ultimately causes cell death. Here we describe a micromanipulation experiment in which we follow in real time a single Drosophila melanogaster topoisomerase II acting on a linear DNA molecule which is mechanically stretched and supercoiled. By monitoring the DNA's extension in the presence of ATP, we directly observe the relaxation of two supercoils during a single catalytic turnover. By controlling the force pulling on the molecule, we determine the variation of the reaction rate with the applied stress. Finally, in the absence of ATP, we observe the clamping of a DNA crossover by a single topoisomerase on at least two different timescales (configurations). These results show that single molecule experiments are a powerful new tool for the study of topoisomerases.

  14. Analysis and compensation for code Doppler effect of BDS II signal under high dynamics

    NASA Astrophysics Data System (ADS)

    Ouyang, Xiaofeng; Zeng, Fangling

    2016-01-01

    In high dynamic circumstances, the acquisition of BDS (BeiDou Navigation Satellite System) signal would be affected by the pseudo-code Doppler. The pseudo-code frequency shift is more prominent and complex when BOC modulation has been adopted by BDS-II, but is not yet involved in current compensation algorithm. In addition, the most frequently used code Doppler compensation algorithm is modifying the sampling rate or local bit rate, which not only increases the complexity of the acquisition and tracking, but also is barely realizable for the hardware receiver to modify the local frequency. Therefore, this paper proposes a code Doppler compensation method based on double estimator receiver, which simultaneously controls NCO delay of code tracking loop and subcarrier tracking loop to compensate for pseudo-code frequency shift. The simulation and test are implemented with BDS-II BOC signal. The test results demonstrate that the proposed algorithm can effectively compensate for pseudo-code Doppler of BOC signal and has detection probability 3dB higher than the uncompensated situation when the false alarm rate is under 0.01 and the coherent integration time is 1ms.

  15. Analysis of the photosystem II by modelling the fluorescence yield transients during 10 seconds after a 10 ns pulse

    NASA Astrophysics Data System (ADS)

    Belyaeva, Natalya E.; Schmitt, Franz-Josef; Paschenko, Vladimir Z.; Riznichenko, Galina Yu.; Rubin, Andrew B.

    2014-10-01

    The dynamics of the photosystem II (PS II) redox states is imitated over nine orders of magnitude in time. Our simulations focus on the information of the chlorophyll a fluorescence induced by a 10 ns laser flash. The PS II model analyzes differences in the PS II reaction between leaves (A. Thaliana, spinach) and thermophilic Chlorella cells.

  16. Curvature corrections and Kac Moody compatibility conditions

    NASA Astrophysics Data System (ADS)

    Damour, Thibault; Hanany, Amihay; Henneaux, Marc; Kleinschmidt, Axel; Nicolai, Hermann

    2006-10-01

    We study possible restrictions on the structure of curvature corrections to gravitational theories in the context of their corresponding Kac Moody algebras, following the initial work on E 10 in Damour and Nicolai [Class Quant Grav 22:2849 (2005)]. We first emphasize that the leading quantum corrections of M-theory can be naturally interpreted in terms of (non-gravity) fundamental weights of E 10. We then heuristically explore the extent to which this remark can be generalized to all over-extended algebras by determining which curvature corrections are compatible with their weight structure, and by comparing these curvature terms with known results on the quantum corrections for the corresponding gravitational theories.

  17. Making Diabetes Clinic Records Computer-Compatible

    PubMed Central

    McKendry, J. B. Ralph; Braaten, Jan T.

    1985-01-01

    Efficient paper records are prerequisites for success in computerizing clinical data on chronic, multi-system diseases such as diabetes. Clinic/office charts can be made more efficient manual records and computer-compatible by use of formats and procedures facilitating collection, selective abstraction, coding and entry of data-to-be-saved. A dated Health Events List is essential. A clinical status profiling process to represent salient features in concise, comprehensible and computer-digestible codes is useful, as is a subsystem to capture and apply patient-generated data. An IBM PC/KnowledgeMan-based diabetes information system subserved by formatted paper records incorporating these devices is in use for clinical care and research purposes.

  18. Is Christian Education Compatible With Science Education?

    NASA Astrophysics Data System (ADS)

    Martin, Michael

    Science education and Christian education are not compatible if by Christian education one means teaching someone to be a Christian. One goal of science education is to give students factual knowledge. Even when there is no actual conflict of this knowledge with the dogmas of Christianity, there exists the potential for conflict. Another goal of science education is to teach students to have the propensity to be sensitive to evidence: to hold beliefs tentatively in light of evidence and to reject these beliefs in the light of new evidence if rejection is warranted by this evidence. This propensity conflicts with one way in which beliefs are often taught in Christian education: namely as fundamental dogmas, rather than as subject to revision in the light of the evidence.

  19. Fuel System Compatibility Issues for Prometheus-1

    SciTech Connect

    DC Noe; KB Gibbard; MH Krohn

    2006-01-20

    Compatibility issues for the Prometheus-1 fuel system have been reviewed based upon the selection of UO{sub 2} as the reference fuel material. In particular, the potential for limiting effects due to fuel- or fission product-component (cladding, liner, spring, etc) chemical interactions and clad-liner interactions have been evaluated. For UO{sub 2}-based fuels, fuel-component interactions are not expected to significantly limit performance. However, based upon the selection of component materials, there is a potential for degradation due to fission products. In particular, a chemical liner may be necessary for niobium, tantalum, zirconium, or silicon carbide-based systems. Multiple choices exist for the configuration of a chemical liner within the cladding; there is no clear solution that eliminates all concerns over the mechanical performance of a clad/liner system. A series of tests to evaluate the performance of candidate materials in contact with real and simulated fission products is outlined.

  20. Toward Clinically Compatible Phase-Contrast Mammography

    PubMed Central

    Scherer, Kai; Willer, Konstantin; Gromann, Lukas; Birnbacher, Lorenz; Braig, Eva; Grandl, Susanne; Sztrókay-Gaul, Anikó; Herzen, Julia; Mayr, Doris; Hellerhoff, Karin; Pfeiffer, Franz

    2015-01-01

    Phase-contrast mammography using laboratory X-ray sources is a promising approach to overcome the relatively low sensitivity and specificity of clinical, absorption-based screening. Current research is mostly centered on identifying potential diagnostic benefits arising from phase-contrast and dark-field mammography and benchmarking the latter with conventional state-of-the-art imaging methods. So far, little effort has been made to adjust this novel imaging technique to clinical needs. In this article, we address the key points for a successful implementation to a clinical routine in the near future and present the very first dose-compatible and rapid scan-time phase-contrast mammograms of both a freshly dissected, cancer-bearing mastectomy specimen and a mammographic accreditation phantom. PMID:26110618